WorldWideScience

Sample records for unification full-text edition

  1. Poetic prayer as a "text in text" in Ukrainian Cyrillic editions of the Baroque age

    Directory of Open Access Journals (Sweden)

    Kurhanova O.

    2016-01-01

    Full Text Available The article observes a prayer as a meta-genre of Baroque Ukrainian poetry, found at the pages of Ukrainian Cyrillic religious editions of the late 16th - early 18th centuries. Double nature of baroque poetic prayer is underlined. Poetic prayer originates from the tradition of liturgical prayer and contains it as a "text in text", at the same time poetical prayer is inserted as a "text in text" into the editions, in which it is printed. Two types of semantic connections between baroque poetic prayers and the text of their editions are described. The first type is presented by the poetry, which contains an image of a person, who took part in the text creation and in the process of its edition: the author/editor (in the role of the prayer addresser or the patron of art (in the role of a person, about whom the prayer request was made. The topics of prayer appellations in the poetry of this group are requests for earthly and heavenly boons for the author/editor/patron of the edition, for positive reception of the book; thanksgivings for the help in the book writing/publishing etc. The poetry of the second type contains images, which are central for the text of an edition. These are, as a rule, addressees of the prayer text - God, Saint Virgin, Angels and Saints. The content of a prayer appeal in the poetry of this type is a request for salvation and help in spiritual self-perfection of a lyric hero or a church community. It is defined that the content of poetic prayers, printed at pages of Cyrillic editions of the late 16th - early 18th centuries, was influenced both by text elements of the edition (topic, central images, and by non-textual factors (illustration plot, accompanied by a poem, prayer intention of an author/editor, existence of a patron of edition, different circumstances of editorial process etc.

  2. Unification and supersymmetry

    International Nuclear Information System (INIS)

    Mohapatra, R.N.

    1991-01-01

    This book deals with some of the latest developments in our attempts to construct a unified theory of the fundamental interactions of nature. Among the topics covered are spontaneous symmetry breaking, grand unified theories, supersymmetry, and supergravity. The book starts with a quick review of elementary particle theory and continues with a discussion of composite quarks, leptons, Higgs bosons, and CP violation; it concludes with consideration of supersymmetric unification schemes, in which bosons and leptons are considered in some sense equivalent. The second edition is updated and corrected and contains new chapters on recent developments

  3. China’s unification: Myth or reality?

    Directory of Open Access Journals (Sweden)

    Estrada Mario Arturo Ruiz

    2014-01-01

    Full Text Available This paper evaluates the prospect of a possible unification between People’s Republic of China (Mainland China and Republic of China (Taiwan from a multi-dimensional perspective which encompasses the political, social, economic, and technological dimensions. The underlying idea is to evaluate the possibility of a partial or total reunification between the two countries in a more comprehensive way than just assessing the economic costs and benefits. Our evaluation is based on the application of the GDRI-Model, which looks at unification and regional integration simultaneously from the political, economic, social and technological perspectives.

  4. Attitudes of second language students towards self-editing their own written texts

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    Daniel Kasule

    2010-05-01

    Full Text Available Recognizing students’ deliberate e!orts to minimize errors in their written texts is valuable in seeing them as responsible active agents in text creation. This paper reports on a brief survey of the attitudes towards self-editing of seventy university students using a questionnaire and class discussion. The context of the study is characterized by its emphasis on evaluating the finished written product. Findings show that students appreciate the role of self-editing in minimizing errors in their texts and that it helps in eventually producing well-written texts. Conceptualizing writing as discourse and therefore as social practice leads to an understanding of writers as socially-situated actors; repositions the student writer as an active agent in text creation; and is central to student-centred pedagogy. We recommend the recognition of self-editing as a vital element in the writing process and that additional error detection mechanisms namely peers, the lecturer, and the computer, increase student autonomy.

  5. Psychotherapy Integration via Theoretical Unification

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    Warren W. Tryon

    2017-01-01

    Full Text Available Meaningful psychotherapy integration requires theoretical unification because psychotherapists can only be expected to treat patients with the same diagnoses similarly if they understand these disorders similarly and if they agree on the mechanisms by which effective treatments work. Tryon (in press has proposed a transtheoretic transdiagnostic psychotherapy based on an Applied Psychological Science (APS clinical orientation, founded on a BioPsychology Network explanatory system that provides sufficient theoretical unification to support meaningful psychotherapy integration. That proposal focused mainly on making a neuroscience argument. This article makes a different argument for theoretical unification and consequently psychotherapy integration. The strength of theories of psychotherapy, like all theory, is to focus on certain topics, goals, and methods. But this strength is also a weakness because it can blind one to alternative perspectives and thereby promote unnecessary competition among therapies. This article provides a broader perspective based on learning and memory that is consistent with the behavioral, cognitive, cognitive-behavioral, psychodynamic, pharmacologic, and Existential/Humanistic/Experiential clinical orientations. It thereby provides a basis for meaningful psychotherapy integration.

  6. Unification predictions

    International Nuclear Information System (INIS)

    Ghilencea, D.; Ross, G.G.; Lanzagorta, M.

    1997-07-01

    The unification of gauge couplings suggests that there is an underlying (supersymmetric) unification of the strong, electromagnetic and weak interactions. The prediction of the unification scale may be the first quantitative indication that this unification may extend to unification with gravity. We make a precise determination of these predictions for a class of models which extend the multiplet structure of the Minimal Supersymmetric Standard Model to include the heavy states expected in many Grand Unified and/or superstring theories. We show that there is a strong cancellation between the 2-loop and threshold effects. As a result the net effect is smaller than previously thought, giving a small increase in both the unification scale and the value of the strong coupling at low energies. (author). 15 refs, 5 figs

  7. Unification types of housing during Sochi Olympics

    Directory of Open Access Journals (Sweden)

    Aleksandr A. Babaev

    2011-05-01

    Full Text Available In the article the statement of the unification problem of housing accommodation of participants, spectators, staff, committee during the Winter Olympics in Sochi. We give a mathematical formalization of the problem, where the unknown variables are theelements of the combination of types of accommodation sorted by the level of comfortand representation.

  8. M theory: a possible unification of physics laws

    International Nuclear Information System (INIS)

    Fernandes, Alexandre da Silva; Silva, Diego Oliveira Nolasco da; Sousa, Claudio Manoel Gomes de

    2011-01-01

    Full text: Physics has two pillars which are mutually incompatible: quantum field theory and general relativity theory. Throughout its history, various unifications have been made, and in attempts to have a better understanding of the birth and formation of the Universe is also necessary to unify these pillars. This unification may require 11 dimensions, and 6 of them are compressed so that it cannot be seen with existing instruments. These dimensions are the spaces in which the strings vibrate, and each mode of vibration corresponds to a particle. The last dimension shows that the universe is a brane, it is in full motion in the multiverse and the collision of two branes can answer the biggest problem of cosmology: what was the Big Bang? Black holes can be explained using a theory that contains gravity and quantum mechanics. The theory is still being developed, some problems are being solved and the main one is the experimental problem, because it requires energy levels that are not yet achieved by current particle accelerators. This work presents M theory as a possibility of unification between the micro and macro, which maybe leading us to the theory of everything. (author)

  9. M theory: a possible unification of physics laws

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, Alexandre da Silva; Silva, Diego Oliveira Nolasco da; Sousa, Claudio Manoel Gomes de [Universidade Catolica de Brasilia (UCB), DF (Brazil)

    2011-07-01

    Full text: Physics has two pillars which are mutually incompatible: quantum field theory and general relativity theory. Throughout its history, various unifications have been made, and in attempts to have a better understanding of the birth and formation of the Universe is also necessary to unify these pillars. This unification may require 11 dimensions, and 6 of them are compressed so that it cannot be seen with existing instruments. These dimensions are the spaces in which the strings vibrate, and each mode of vibration corresponds to a particle. The last dimension shows that the universe is a brane, it is in full motion in the multiverse and the collision of two branes can answer the biggest problem of cosmology: what was the Big Bang? Black holes can be explained using a theory that contains gravity and quantum mechanics. The theory is still being developed, some problems are being solved and the main one is the experimental problem, because it requires energy levels that are not yet achieved by current particle accelerators. This work presents M theory as a possibility of unification between the micro and macro, which maybe leading us to the theory of everything. (author)

  10. The Unification of Private International Law

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    Emira Kazazi

    2015-07-01

    Full Text Available Civil and the common law approaching Europe is no longer a “future project”, but more and more rather a present attempt (Kötz, 2003 – 2004. In this prism, concentrating on the European International Private Law within the space of mixed jurisdictions, it may seem surprising in light of the attempts to create a new European ius commune. But is it possible that a unification of the material law may sign the start of the end of the European conflicts of laws? Last but not the least private international law is not just a choice of law. The unification of the private law, in its definition as a concept, does not influence two of the three pillars of the private international law: respectively, that of the jurisdiction and recognition as well as implementation of foreign decisions.

  11. MT Post-editing: A Text Repair Experience for the Foreign Language Class.

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    Ana Niño

    2007-04-01

    Full Text Available Communication also means having to sort out the problems involved in learning a foreign language, especially with regards to production rather than reception. These learning strategies or skills can also be applied to translation teaching methodology, where students put in practice their risk taking, avoidance, reduction and/ or compensatory strategies in getting the message across. We acknowledge translation as a writing task constrained by the source text. In addition, the translation and the writing cycles have in common a generation stage and a revision stage where grammatical, lexical and stylistic correctness is assessed. Somewhere in the middle between translation and writing skills lies MT (Machine Translation post-editing that involves correcting the raw MT output with the aim of providing a quality text according to the intended purpose. Our research is intended to test the suitability of MT post-editing as an activity to promote error correction and, subsequently, to enhance written production in second and foreign language teaching.

  12. Functional Pearls : Polytypic Unification

    NARCIS (Netherlands)

    Jansson, P.; Jeuring, J.T.

    1998-01-01

    Unification, or two-way pattern matching, is the process of solving an equation involving two first-order terms with variables. Unification is used in type inference in many programming languages and in the execution of logic programs. This means that unification algorithms have to be written over

  13. Unification beyond GUT's: Gauge-Yukawa unification

    International Nuclear Information System (INIS)

    Kubo, J.; Mondragon, M.; Zoupanos, G.

    1996-01-01

    Gauge-Yukawa Unification (GYU) is a renormalization group invariant functional relation among gauge and Yukawa couplings which holds beyond the unification point in Grand Unified Theories (GUTs). We present here various models where GYU is obtained by requiring the principles of finiteness and reduction of couplings. We examine the consequences of these requirements for the low energy parameters, especially for the top quark mass. The predictions are such that they clearly distinguish already GYU from ordinary GUTs. It is expected that it will be possible to discriminate among the various GYUs when more accurate measurements of the top quark mass are available. (author)

  14. Direct mediation, duality and unification

    International Nuclear Information System (INIS)

    Abel, Steven; Khoze, Valentin V.

    2008-01-01

    It is well-known that in scenarios with direct gauge mediation of supersymmetry breaking the messenger fields significantly affect the running of Standard Model couplings and introduce Landau poles which are difficult to avoid. Among other things, this appears to remove any possibility of a meaningful unification prediction and is often viewed as a strong argument against direct mediation. We propose two ways that Seiberg duality can circumvent this problem. In the first, which we call 'deflected-unification', the SUSY-breaking hidden sector is a magnetic theory which undergoes a Seiberg duality to an electric phase. Importantly, the electric version has fewer fundamental degrees of freedom coupled to the MSSM compared to the magnetic formulation. This changes the β-functions of the MSSM gauge couplings so as to push their Landau poles above the unification scale. We show that this scenario is realised for recently suggested models of gauge mediation based on a metastable SCQD-type hidden sector directly coupled to MSSM. The second possibility for avoiding Landau poles, which we call 'dual-unification', begins with the observation that, if the mediating fields fall into complete SU(5) multiplets, then the MSSM+messengers exhibits a fake unification at unphysical values of the gauge couplings. We show that, in known examples of electric/magnetic duals, such a fake unification in the magnetic theory reflects a real unification in the electric theory. We therefore propose that the Standard Model could itself be a magnetic dual of some unknown electric theory in which the true unification takes place. This scenario maintains the unification prediction (and unification scale) even in the presence of Landau poles in the magnetic theory below the GUT scale. We further note that this dual realization of grand unification can explain why Nature appears to unify, but the proton does not decay.

  15. Grand unification theory and technicolor

    International Nuclear Information System (INIS)

    Rubakov, V.A.; Shaposhnikov, M.E.

    1983-01-01

    The lecture course can be considered as introduction to the problems concerning grand unification models. The course is incomplete. Such problems as CP-violations in strong interactions and the problem of gravitational interaction inclusion in the scheme of grand unification theory are not touched upon. Models of early unification, in which strong, weak and electromagnetic interactions are compared according to the ''strength'' at energies of about 10 5 -10 6 GeV, are not discussed. Models with horizontal symmetry, considering different generations of quarks and leptons from one viewpoint, are not analyzed. Cosmological applications of supersymmetric unified theories are not considered. Certain problems of standard elementary particle theory, philosophy of the great unification, general properties of the grand unification models and the main principles of the construction of models: the SU(5) model, models on the SO(10) groups, have been considered. The problem of supersymmetric unification hierarchies, supersymmetric generalization of the minimum SU(5) model, supersymmetry violation and the problem of hierarchies, phenomenology of the o.rand unification models, cosmological application and technicolour, are discussed

  16. WYLBUR reference manual. [For interactive text editing

    Energy Technology Data Exchange (ETDEWEB)

    Krupp, R.F.; Messina, P.C.; Peavler, J.M.; Schustack, S.; Starai, T.

    1977-04-01

    WYLBUR is a system for manipulating various kinds of text, such as computer programs, manuscripts, letters, forms, articles, or reports. Its on-line interactive text-editing capabilities allow the user to create, change, and correct text, and to search and display it. WYLBUR also has facilities for job submission and retrieval from remote terminals that make it possible for a user to inquire about the status of any job in the system, cancel jobs that are executing or awaiting execution, reroute output, raise job priority, or get information on the backlog of batch jobs. WYLBUR also has excellent recovery capabilities and a fast response time. This manual describes the WYLBUR version currently used at ANL. It is intended primarily as a reference manual; thus, examples of WYLBUR commands are kept to a minimum. (RWR)

  17. Exploring the Use of Enterprise Content Management Systems in Unification Types of Organizations

    Directory of Open Access Journals (Sweden)

    Arshad Noreen Izza

    2014-03-01

    Full Text Available The aim of this paper is to better understand how highly standardized and integrated businesses known as unification types of organizations use Enterprise Content Management Systems (ECMS to support their business processes. Multiple case study approach was used to study the ways two unification organizations use their ECMS in their daily work practices. Arising from these case studies are insights into the differing ways in which ECMS is used to support businesses. Based on the comparisons of the two cases, this study proposed that unification organizations may use ECMS in four ways, for: (1 collaboration, (2 information sharing that supports a standardized process structure, (3 building custom workflows that support integrated and standardized processes, and (4 providing links and access to information systems. These findings may guide organizations that are highly standardized and integrated in fashion, to achieve their intended ECMS-use, to understand reasons for ECMS failures and underutilization and to exploit technologies investments.

  18. Dark Matter after LHC Run I: Clues to Unification

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    Olive Keith A.

    2017-01-01

    Full Text Available After the results of Run I, can we still ‘guarantee’ the discovery of supersymmetry at the LHC? It is shown that viable dark matter models in CMSSM-like models tend to lie in strips (co-annihilation, funnel, focus point. The role of grand unification in constructing supersymmetric models is discussed and it is argued that non-supersymmetric GUTs such as SO(10 may provide solutions to many of the standard problems addressed by supersymmetry.

  19. MUC (Memory, Unification, Control and beyond

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    Peter eHagoort

    2013-07-01

    Full Text Available A neurobiological model of language is discussed that overcomes the shortcomings of the classical Wernicke-Lichtheim-Geschwind model. It is based on a subdivision of language processing into three components: Memory, Unification, and Control. The functional components as well as the neurobiological underpinnings of the model are discussed. In addition, the need for extension of the model beyond the classical core regions for language is shown. Attentional networks as well as networks for inferential processing are crucial to realize language comprehension beyond single word processing and beyond decoding propositional content. It is shown that this requires the dynamic interaction between multiple brain regions.

  20. SAT Encoding of Unification in EL

    Science.gov (United States)

    Baader, Franz; Morawska, Barbara

    Unification in Description Logics has been proposed as a novel inference service that can, for example, be used to detect redundancies in ontologies. In a recent paper, we have shown that unification in EL is NP-complete, and thus of a complexity that is considerably lower than in other Description Logics of comparably restricted expressive power. In this paper, we introduce a new NP-algorithm for solving unification problems in EL, which is based on a reduction to satisfiability in propositional logic (SAT). The advantage of this new algorithm is, on the one hand, that it allows us to employ highly optimized state-of-the-art SAT solvers when implementing an EL-unification algorithm. On the other hand, this reduction provides us with a proof of the fact that EL-unification is in NP that is much simpler than the one given in our previous paper on EL-unification.

  1. SU(5) unification revisited

    International Nuclear Information System (INIS)

    Giveon, A.; Sarid, U.; Hall, L.J.; California Univ., Berkeley, CA

    1991-01-01

    Model-independent criteria for unification in the SU(5) framework are studied. These are applied to the minimal supersymmetric standard model and to the standard model with a split 45 Higgs representation. Although the former is consistent with SU(5) unification, the superpartner masses can vary over a wide range, and may even all lie well beyond the reach of planned colliders. Adding a split 45 to the standard model can also satisfy the unification criteria, so supersymmetric SU(5) is far from unique. Furthermore, we learn that separate Higgs doublets must couple to the top and bottom quarks in order to give a correct m b /m τ prediction. (orig.)

  2. [Regimento proueytoso and Modus curandi: edition of the texts].

    Science.gov (United States)

    Rosa, Maria Carlota; de Carvalho, Diana Maul; Teixeira, Dante Martins

    2005-01-01

    This issue features facsimiles of Regimento proueytoso contra ha pestenença and Modus curandi cum balsamo, based on the original texts housed in the Biblioteca Pública de Evora and the Biblioteca Nacional de Portugal, respectively. Semi-diplomatic editions of both facsimiles--with transliterations into modern characters--have also been provided. These are followed by translations, in the case of Regimento from old to modern Portuguese and in the case of Modus curandi from Latin to modern-day Portuguese. This text explains the criteria used in preparing the semi-diplomatic versions and in modernizing the text of Regimento.

  3. Low-scale gaugino mass unification

    International Nuclear Information System (INIS)

    Endo, M.; Yoshioka, K.

    2008-04-01

    We present a new class of scenarios with the gaugino mass unification at the weak scale. The unification conditions are generally classified and then, the mirage gauge mediation is explored where gaugino masses are naturally unified and scalar partners of quarks and leptons have no mass hierarchy. The low-energy mass spectrum is governed by the mirage of unified gauge coupling which is seen by low-energy observers. We also study several explicit models for dynamically realizing the TeV-scale unification. (orig.)

  4. Low-scale gaugino mass unification

    Energy Technology Data Exchange (ETDEWEB)

    Endo, M [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Yoshioka, K [Kyoto Univ. (Japan). Dept. of Physics

    2008-04-15

    We present a new class of scenarios with the gaugino mass unification at the weak scale. The unification conditions are generally classified and then, the mirage gauge mediation is explored where gaugino masses are naturally unified and scalar partners of quarks and leptons have no mass hierarchy. The low-energy mass spectrum is governed by the mirage of unified gauge coupling which is seen by low-energy observers. We also study several explicit models for dynamically realizing the TeV-scale unification. (orig.)

  5. Reinventing Consumption Traditions through the Process of Unification of a Country: Understanding “Good Bye Lenin!”

    Directory of Open Access Journals (Sweden)

    Ece Ceren Engür

    2016-02-01

    Full Text Available This paper focuses on the change of consumption traditions in terms of re-unification of a country. The discussion bases on the movie, “Good Bye Lenin!”(2003 and chases the transformations on consumption trends in order to understand how the re-unification of East and West Germany influences the practices of everyday life after a four decade long segregation. The movie displays the 1990’s Germany during the times when the Berlin Wall falls and frames a family portrait which is dominated by an idealist and traditional mother character in the last days of her life.

  6. Family unification in five and six dimensions

    International Nuclear Information System (INIS)

    Babu, K.S.; Barr, S.M.; Kyae, Bumseok

    2002-01-01

    In family unification models, all three families of quarks and leptons are grouped together into an irreducible representation of a simple gauge group, thus unifying the standard model gauge symmetries and a gauged family symmetry. Large orthogonal groups, and the exceptional groups E 7 and E 8 , have been much studied for family unification. The main theoretical difficulty of family unification is the existence of mirror families at the weak scale. It is shown here that family unification without mirror families can be realized in simple five-dimensional and six-dimensional orbifold models similar to those recently proposed for SU(5) and SO(10) grand unification. It is noted that a family unification group that survived to near the weak scale and whose coupling extrapolated to high scales unified with those of the standard model would be evidence, accessible in principle at low energy, of the existence of small (Planckian or GUT-scale) extra dimensions

  7. Light higgsino for gauge coupling unification

    Directory of Open Access Journals (Sweden)

    Kwang Sik Jeong

    2017-06-01

    Full Text Available We explore gauge coupling unification and dark matter in high scale supersymmetry where the scale of supersymmetry breaking is much above the weak scale. The gauge couplings unify as precisely as in low energy supersymmetry if the higgsinos, whose mass does not break supersymmetry, are much lighter than those obtaining masses from supersymmetry breaking. The dark matter of the universe can then be explained by the neutral higgsino or the gravitino. High scale supersymmetry with light higgsinos requires a large Higgs mixing parameter for electroweak symmetry breaking to take place. It is thus naturally realized in models where superparticle masses are generated at loop level while the Higgs mixing parameter is induced at tree level, like in anomaly and gauge mediation of supersymmetry breaking.

  8. Fan edits and the legacy of The Phantom Edit

    Directory of Open Access Journals (Sweden)

    Joshua Wille

    2014-09-01

    Full Text Available A fan edit can generally be defined as an alternative version of a film or television text created by a fan. It offers a different viewing experience, much as a song remix offers a different listening experience. The contemporary wave of fan edits has emerged during the remix zeitgeist of digital media and at a time when digital video editing technology has become more affordable and popular. The increasing number of alternative versions of films and the works of revisionist Hollywood filmmakers such as George Lucas have contributed to a greater public understanding of cinema as a fluid medium instead of one that exists in a fixed form. The Phantom Edit (2000, a seminal fan edit based on Lucas's Star Wars Episode I: The Phantom Menace (1999, inspired new ranks of fan editors. However, critics have misunderstood fan edits as merely the work of disgruntled fans. In order to provide a critical and historical basis for studies in fan editing as a creative practice, I examine previous interpretations of fan edits in the context of relevant contemporary works, and I use an annotated chronology of The Phantom Edit to trace its influence on subsequent fan editing communities and uncover their relationship with intellectual property disputes.

  9. THE COMPLETION OF THE CHURCH UNIFICATION FROM 1700-1701 UNDER THE BISHOP ATANASIE

    Directory of Open Access Journals (Sweden)

    Florin-Alin OROS

    2013-11-01

    Full Text Available The religious unification around year 1700, betweeen a part of the Orthodox believers from Transylvania and the Church of Rome, of Catholic religion, had represented an event that left a profound spiritual mark on the Romanian and Transylvanian population. The efforts for a Unification had started under the Orthodox bishop from Transylvania, Teofil (1692-1697, a part of the Orthodox priests being willing to accept it for a series of rights and benefits. These efforts could not be accomplished because of the sudden death of the bishop in 1697. As a result of the endeavours of the next bishop of the Romanians, Atanasie, a part of the Orthodox believers had joined the new Greek-Catholic communion around 1700-1701. There is no doubt that this historical and religious endeavour was not an easy one, Atanasie being compelled to „sail” in the muddy waters of the religious structure in Transylvania. This oscillation between the Orthodox and Catholic religions, under the strict supervision of the Imperial authorities from Wien, had triggered the completion of the religious Unification at the beginning of the 18th century and the development of the Greek-Catholic church in Transylvania.

  10. Editing Bosman's stories | MacKenzie | Current Writing: Text and ...

    African Journals Online (AJOL)

    This article looks back at the editing work that went into the fourteen-volume Anniversary Edition of Herman Charles Bosman (1998–2005) and pays particular attention to the editing of Bosman's stories. It examines some of the problems that were encountered in arriving at 'authoritative' versions of the stories and argues ...

  11. Low-energy parity restoration and unification mass scale within maximal symmetries

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    Ajaya K. Mohanty

    1984-01-01

    Full Text Available We investigate the hierarchy of gauge boson masses in the maximal grand unified theory by studying the renormalization group equations for the running coupling constants associated with the symmetry breaking of SU(16viaSU(12 q×SU(4 l×U(1 |B|−|L| chain. Particular attention is given to the contribution of Higgs scalars to these equations. It is found that the intermediate mass scale ML, associated with right-handed gauge bosons could be as low as 10 3 GeV only for sin 2θ w(M L as high as 0.265 with α s(M L=0.13. In this chain of symmetry breaking, we have also examined the lowest unification mass that is allowed by the low-energy data for sin 2θ w(M L and the assumed gauge hierarchy. This has been done in two cases; first for the case where SU(3 c is vectorial, second, for the case where SU(3 c is axial. In both cases the lowest unification mass scales were found to be 10 13, 10 11, 10 8 and 10 7 GeV for sin 2θ w(M L = 0.22, 0.24, 0.26,and0.265 respectively with α s(M L = 0.13. The implication of these low unification masses on baryon non-conserving processes is also discussed.

  12. Reformulating XQuery queries using GLAV mapping and complex unification

    Directory of Open Access Journals (Sweden)

    Saber Benharzallah

    2016-01-01

    Full Text Available This paper describes an algorithm for reformulation of XQuery queries. The mediation is based on an essential component called mediator. Its main role is to reformulate a user query, written in terms of global schema, into queries written in terms of source schemas. Our algorithm is based on the principle of logical equivalence, simple and complex unification, to obtain a better reformulation. It takes XQuery query, global schema (written in XMLSchema, and mappings GLAV as input parameters and provides resultant query written in terms of source schemas. The results of implementation show the proper functioning of the algorithm.

  13. vi and Vim Editors Pocket Reference Support for every text editing task

    CERN Document Server

    Robbins, Arnold

    2011-01-01

    Many Unix, Linux, and Mac OS X geeks enjoy using the powerful, platform-agnostic text editors vi and Vim, but there are far too many commands for anyone to remember. Author Arnold Robbins has chosen the most valuable commands for vi, Vim, and vi's main clones-vile, elvis, and nvi-and packed them into this easy-to-browse pocket reference. You'll find commands for all kinds of editing tasks, such as programming, modifying system files, and writing and marking up articles. This second edition includes: Command-line optionsvi commands and set optionsInput mode shortcutsSubstitution and regular e

  14. Preon Model and Family Replicated E_6 Unification

    Directory of Open Access Journals (Sweden)

    Larisa V. Laperashvili

    2008-02-01

    Full Text Available Previously we suggested a new preon model of composite quark-leptons and bosons with the 'flipped' $E_6imes widetilde{E_6}$ gauge symmetry group. We assumed that preons are dyons having both hyper-electric $g$ and hyper-magnetic $ilde g$ charges, and these preons-dyons are confined by hyper-magnetic strings which are an ${f N}=1$ supersymmetric non-Abelian flux tubes created by the condensation of spreons near the Planck scale. In the present paper we show that the existence of the three types of strings with tensions $T_k=k T_0$ $(k = 1,2,3$ producing three (and only three generations of composite quark-leptons, also provides three generations of composite gauge bosons ('hyper-gluons' and, as a consequence, predicts the family replicated $[E_6]^3$ unification at the scale $sim 10^{17}$ GeV. This group of unification has the possibility of breaking to the group of symmetry: $ [SU(3_C]^3imes [SU(2_L]^3imes [U(1_Y]^3 imes [U(1_{(B-L}]^3$ which undergoes the breakdown to the Standard Model at lower energies. Some predictive advantages of the family replicated gauge groups of symmetry are briefly discussed.

  15. Effective Higgs theories in supersymmetric grand unification

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Sibo [Chongqing University, Department of Physics, Chongqing (China)

    2017-09-15

    The effective Higgs theories at the TeV scale in supersymmetric SU(5) grand unification models are systematically derived. Restricted to extensions on 5{sub H} containing the Higgs sector we show that only two types of real (vector-like) models and one type of chiral model are found to be consistent with perturbative grand unification. While the chiral model has been excluded by the LHC data, the fate of perturbative unification will be uniquely determined by the two classes of vector-like models. (orig.)

  16. The Medline/full-text research project.

    Science.gov (United States)

    McKinin, E J; Sievert, M; Johnson, E D; Mitchell, J A

    1991-05-01

    This project was designed to test the relative efficacy of index terms and full-text for the retrieval of documents in those MEDLINE journals for which full-text searching was also available. The full-text files used were MEDIS from Mead Data Central and CCML from BRS Information Technologies. One hundred clinical medical topics were searched in these two files as well as the MEDLINE file to accumulate the necessary data. It was found that full-text identified significantly more relevant articles than did the indexed file, MEDLINE. The full-text searches, however, lacked the precision of searches done in the indexed file. Most relevant items missed in the full-text files, but identified in MEDLINE, were missed because the searcher failed to account for some aspect of natural language, used a logical or positional operator that was too restrictive, or included a concept which was implied, but not expressed in the natural language. Very few of the unique relevant full-text citations would have been retrieved by title or abstract alone. Finally, as of July, 1990 the more current issue of a journal was just as likely to appear in MEDLINE as in one of the full-text files.

  17. Higher-derivative Lee-Wick unification

    International Nuclear Information System (INIS)

    Carone, Christopher D.

    2009-01-01

    We consider gauge coupling unification in Lee-Wick extensions of the Standard Model that include higher-derivative quadratic terms beyond the minimally required set. We determine how the beta functions are modified when some Standard Model particles have two Lee-Wick partners. We show that gauge coupling unification can be achieved in such models without requiring the introduction of additional fields in the higher-derivative theory and we comment on possible ultraviolet completions.

  18. Minimal SUSY SO(10) and Yukawa unification

    International Nuclear Information System (INIS)

    Okada, Nobuchika

    2013-01-01

    The minimal supersymmetric (SUSY) SO(10) model, where only two Higgs multiplets {10⊕126-bar} are utilized for Yukawa couplings with matter fields, can nicely fit the neutrino oscillation parameters as well as charged fermion masses and mixing angles. In the fitting of the fermion mass matrix data, the largest element in the Yukawa coupling with the 126-bar -plet Higgs (Y 126 ) is found to be of order one, so that the right see-saw scale should be provided by Higgs vacuum expectation values (VEVs) of β(10 14 GeV). This fact causes a serious problem, namely, the gauge coupling unification is spoiled because of the presence of many exotic Higgs multiples emerging at the see-saw scale. In order to solve this problem, we consider a unification between bottom-quark and tau Yukawa couplings (b - τ Yukawa coupling unification) at the grand unified theory (GUT) scale, due to threshold corrections of superpartners to the Yukawa couplings at the 1 TeV scale. When the b - τ Yukawa coupling unification is very accurate, the largest element in Y 126 can become β(0.01), so that the right see-saw scale is realized by the GUT scale VEV and the usual gauge coupling unification is maintained. Since the b - τ Yukawa unification alters the Yukawa coupling data at the GUT scale, we re-analyze the fitting of the fermion mass matrix data by taking all the relevant free parameters into account. Unfortunately, we find that no parameter region shows up to give a nice fit for the current neutrino oscillation data and therefore, the usual picture of the gauge coupling unification cannot accommodate the fermion mass matrix data fitting in our procedure.

  19. Where Full-Text Is Viable.

    Science.gov (United States)

    Cotton, P. L.

    1987-01-01

    Defines two types of online databases: source, referring to those intended to be complete in themselves, whether full-text or abstracts; and bibliographic, meaning those that are not complete. Predictions are made about the future growth rate of these two types of databases, as well as full-text versus abstract databases. (EM)

  20. Gauge coupling unification in superstring derived standard-like models

    International Nuclear Information System (INIS)

    Faraggi, A.E.

    1992-11-01

    I discuss gauge coupling unification in a class of superstring standard-like models, which are derived in the free fermionic formulation. Recent calculations indicate that the superstring unification scale is at O(10 18 GeV) while the minimal supersymmetric standard model is consistent with LEP data if the unification scale is at O(10 16 )GeV. A generic feature of the superstring standard-like models is the appearance of extra color triplets (D,D), and electroweak doublets (l,l), in vector-like representations, beyond the supersymmetric standard model. I show that the gauge coupling unification at O(10 18 GeV) in the superstring standard-like models can be consistent with LEP data. I present an explicit standard-like model that can realize superstring gauge coupling unification. (author)

  1. Proton hexality in local grand unification

    Energy Technology Data Exchange (ETDEWEB)

    Foerste, Stefan; Nilles, Hans Peter [Bonn Univ. (Germany). Bethe Center for Theoretical Physics and Physikalisches Institut; Ramos-Sanchez, Saul [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Vaudrevange, Patrick K.S. [Muenchen Univ. (Germany). Arnold Sommerfeld Center for Theoretical Physics

    2010-07-15

    Proton hexality is a discrete symmetry that avoids the problem of too fast proton decay in the supersymmetric extension of the standard model. Unfortunately it is inconsistent with conventional grand unification. We show that proton hexality can be incorporated in the scheme of ''Local Grand Unification'' discussed in the framework of model building in (heterotic) string theory. (orig.)

  2. Application of image editing software for forensic detection of image ...

    African Journals Online (AJOL)

    Application of image editing software for forensic detection of image. ... The image editing software's available today is apt for creating visually compelling and sophisticated fake images, ... EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT

  3. Systematic characterizations of text similarity in full text biomedical publications.

    Science.gov (United States)

    Sun, Zhaohui; Errami, Mounir; Long, Tara; Renard, Chris; Choradia, Nishant; Garner, Harold

    2010-09-15

    Computational methods have been used to find duplicate biomedical publications in MEDLINE. Full text articles are becoming increasingly available, yet the similarities among them have not been systematically studied. Here, we quantitatively investigated the full text similarity of biomedical publications in PubMed Central. 72,011 full text articles from PubMed Central (PMC) were parsed to generate three different datasets: full texts, sections, and paragraphs. Text similarity comparisons were performed on these datasets using the text similarity algorithm eTBLAST. We measured the frequency of similar text pairs and compared it among different datasets. We found that high abstract similarity can be used to predict high full text similarity with a specificity of 20.1% (95% CI [17.3%, 23.1%]) and sensitivity of 99.999%. Abstract similarity and full text similarity have a moderate correlation (Pearson correlation coefficient: -0.423) when the similarity ratio is above 0.4. Among pairs of articles in PMC, method sections are found to be the most repetitive (frequency of similar pairs, methods: 0.029, introduction: 0.0076, results: 0.0043). In contrast, among a set of manually verified duplicate articles, results are the most repetitive sections (frequency of similar pairs, results: 0.94, methods: 0.89, introduction: 0.82). Repetition of introduction and methods sections is more likely to be committed by the same authors (odds of a highly similar pair having at least one shared author, introduction: 2.31, methods: 1.83, results: 1.03). There is also significantly more similarity in pairs of review articles than in pairs containing one review and one nonreview paper (frequency of similar pairs: 0.0167 and 0.0023, respectively). While quantifying abstract similarity is an effective approach for finding duplicate citations, a comprehensive full text analysis is necessary to uncover all potential duplicate citations in the scientific literature and is helpful when

  4. Decimal Classification Editions

    Directory of Open Access Journals (Sweden)

    Zenovia Niculescu

    2009-01-01

    Full Text Available The study approaches the evolution of Dewey Decimal Classification editions from the perspective of updating the terminology, reallocating and expanding the main and auxilary structure of Dewey indexing language. The comparative analysis of DDC editions emphasizes the efficiency of Dewey scheme from the point of view of improving the informational offer, through basic index terms, revised and developed, as well as valuing the auxilary notations.

  5. SU(5) unification with TeV-scale leptoquarks

    Energy Technology Data Exchange (ETDEWEB)

    Cox, Peter [Kavli Institute for the Physics and Mathematics of the Universe (WPI), UTIAS,The University of Tokyo, Kashiwa, Chiba, 277-8583 (Japan); Kusenko, Alexander [Department of Physics and Astronomy, University of California,Los Angeles, CA, 90095-1547 (United States); Kavli Institute for the Physics and Mathematics of the Universe (WPI), UTIAS,The University of Tokyo, Kashiwa, Chiba, 277-8583 (Japan); Sumensari, Olcyr [Laboratoire de Physique Théorique, CNRS, Université Paris-Sud, Université Paris-Saclay,Orsay, 91405 (France); Instituto de Física, Universidade de São Paulo,C.P. 66.318, São Paulo, 05315-970 (Brazil); Yanagida, Tsutomu T. [Kavli Institute for the Physics and Mathematics of the Universe (WPI), UTIAS,The University of Tokyo, Kashiwa, Chiba, 277-8583 (Japan)

    2017-03-07

    It was previously noted that SU(5) unification can be achieved via the simple addition of light scalar leptoquarks from two split 10 multiplets. We explore the parameter space of this model in detail and find that unification requires at least one leptoquark to have mass below ≈16 TeV. We point out that introducing splitting of the 24 allows the unification scale to be raised beyond 10{sup 16} GeV, while a U(1){sub PQ} symmetry can be imposed to forbid dangerous proton decay mediated by the light leptoquarks. The latest bounds from LHC searches are combined and we find that a leptoquark as light as 400 GeV is still permitted. Finally, we discuss the interesting possibility that the leptoquarks required for unification could also be responsible for the 2.6σ deviation observed in the ratio R{sub K} at LHCb.

  6. The economic implications of Korean unification

    OpenAIRE

    Schmitz, Jonathan L.

    2002-01-01

    Approved for public release; distribution unlimited A major area of concern for Korean unification is the immense cost it will impose on South Korea. To lessen this burden, South Korea will need to initiate policy reforms that can ease the financial stress and repercussions of unification and create an integrated economic community with North Korea. At the same time, North Korea will need to create an environment that is conducive to economic integration by accepting and adopting reform me...

  7. Grand unification and gravity - selected topics

    International Nuclear Information System (INIS)

    Zee, A.

    1981-09-01

    The material given here was presented in lectures delivered at the 4th Kyoto Summer Institute on Grand Unification and Related Topics. It consists of six sections. The sections are: the family problem, fermion mass hierarchy, maximal local symmetry, operator analysis of new physics, dynamically generated gravity, and Kaluza theory and grand unification. The last section contains a (hopefully) pedagogical introduction to Kaluza theory. For pedagogical completeness, several appendices reviewing some elementary notions of differential geometry have been added

  8. Towards worldwide height unification using ocean information

    Directory of Open Access Journals (Sweden)

    P. L. Woodworth

    2015-03-01

    Full Text Available This paper describes how we are contributing to worldwide height system unification (WHSU by using ocean models together with sea level (tide gauge and altimeter information, geodetic (GPS and levelling data, and new geoid models based on information from the GRACE and GOCE gravity missions, to understand how mean sea level (MSL varies from place to place along the coast. For the last two centuries, MSL has been used to define datums for national levelling systems. However, there are many problems with this. One consequence of WHSU will be the substitution of conventional datums as a reference for heights with the use of geoid, as the only true "level" or datum. This work is within a number of GOCE-related activities funded by the European Space Agency. The study is focused on the coastlines of North America and Europe where the various datasets are most copious.

  9. Structural convergence under reversible and irreversible monetary unification

    NARCIS (Netherlands)

    Beetsma, R.M.W.J.; Jensen, H.

    2003-01-01

    We explore endogenous monetary unification in the context of a model in which a country with serious structural distortions (and, hence, high inflation) is admitted into a monetary union once its economic structure has converged sufficiently towards that of the existing participants. If unification

  10. Structural convergence under reversible and irreversible monetary unification

    NARCIS (Netherlands)

    Beetsma, R.M.W.J.; Jensen, H.

    1999-01-01

    We explore endogenous monetary unification in the context of a model in which a country with serious structural distortions (and, hence, high inflation) is admitted into a monetary union once its economic structure has converged sufficiently towards that of the existing participants. If unification

  11. Hidden SUSY from precision gauge unification

    Energy Technology Data Exchange (ETDEWEB)

    Krippendorf, Sven; Nilles, Hans Peter [Bonn Univ. (Germany). Bethe Center for Theoretical Physics; Bonn Univ. (Germany). Physikalisches Inst.; Ratz, Michael [Technische Univ. Muenchen, Garching (Germany). Physik-Department; Winkler, Martin Wolfgang [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2013-06-15

    We revisit the implications of naturalness and gauge unification in the MSSM. We find that precision unification of the couplings in connection with a small {mu} parameter requires a highly compressed gaugino pattern as it is realized in mirage mediation. Due to the small mass difference between gluino and LSP, collider limits on the gluino mass are drastically relaxed. Without further assumptions, the relic density of the LSP is very close to the observed dark matter density due to coannihilation effects.

  12. Hidden SUSY from precision gauge unification

    International Nuclear Information System (INIS)

    Krippendorf, Sven; Nilles, Hans Peter

    2013-06-01

    We revisit the implications of naturalness and gauge unification in the MSSM. We find that precision unification of the couplings in connection with a small μ parameter requires a highly compressed gaugino pattern as it is realized in mirage mediation. Due to the small mass difference between gluino and LSP, collider limits on the gluino mass are drastically relaxed. Without further assumptions, the relic density of the LSP is very close to the observed dark matter density due to coannihilation effects.

  13. Reduced modular symmetries of threshold corrections and gauge coupling unification

    Energy Technology Data Exchange (ETDEWEB)

    Bailin, David; Love, Alex [Department of Physics & Astronomy, University of Sussex,Brighton, BN1 9QH (United Kingdom)

    2015-04-01

    We revisit the question of gauge coupling unification at the string scale in orbifold compactifications of the heterotic string for the supersymmetric Standard Model. In the presence of discrete Wilson lines threshold corrections with modular symmetry that is a subgroup of the full modular group arise. We find that reduced modular symmetries not previously reported are possible. We conjecture that the effects of such threshold corrections can be simulated using sums of terms built from Dedekind eta functions to obtain the appropriate modular symmetry. For the cases of the ℤ{sub 8}-I orbifold and the ℤ{sub 3}×ℤ{sub 6} orbifold it is easily possible to obtain gauge coupling unification at the “observed” scale with Kähler moduli T of approximately one.

  14. CASSINI V/E/J/S/SS RPWS EDITED WAVEFORM FULL RES V1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — The Cassini Radio and Plasma Wave Science (RPWS) edited full resolution data set includes all waveform data for the entire Cassini mission. This data set includes...

  15. Dark matter from unification

    DEFF Research Database (Denmark)

    Kainulainen, Kimmo; Tuominen, Kimmo; Virkajärvi, Jussi Tuomas

    2013-01-01

    We consider a minimal extension of the Standard Model (SM), which leads to unification of the SM coupling constants, breaks electroweak symmetry dynamically by a new strongly coupled sector and leads to novel dark matter candidates. In this model, the coupling constant unification requires...... eigenstates of this sector and determine the resulting relic density. The results are constrained by available data from colliders and direct and indirect dark matter experiments. We find the model viable and outline briefly future research directions....... the existence of electroweak triplet and doublet fermions singlet under QCD and new strong dynamics underlying the Higgs sector. Among these new matter fields and a new right handed neutrino, we consider the mass and mixing patterns of the neutral states. We argue for a symmetry stabilizing the lightest mass...

  16. Academic Journal Embargoes and Full Text Databases.

    Science.gov (United States)

    Brooks, Sam

    2003-01-01

    Documents the reasons for embargoes of academic journals in full text databases (i.e., publisher-imposed delays on the availability of full text content) and provides insight regarding common misconceptions. Tables present data on selected journals covering a cross-section of subjects and publishers and comparing two full text business databases.…

  17. The Weaknesses of Full-Text Searching

    Science.gov (United States)

    Beall, Jeffrey

    2008-01-01

    This paper provides a theoretical critique of the deficiencies of full-text searching in academic library databases. Because full-text searching relies on matching words in a search query with words in online resources, it is an inefficient method of finding information in a database. This matching fails to retrieve synonyms, and it also retrieves…

  18. Simple unification

    International Nuclear Information System (INIS)

    Ponce, W.A.; Zepeda, A.

    1987-08-01

    We present the results obtained from our systematic search of a simple Lie group that unifies weak and electromagnetic interactions in a single truly unified theory. We work with fractionally charged quarks, and allow for particles and antiparticles to belong to the same irreducible representation. We found that models based on SU(6), SU(7), SU(8) and SU(10) are viable candidates for simple unification. (author). 23 refs

  19. Bibliography of Fynbos ecology: 2nd edition

    CSIR Research Space (South Africa)

    Manders, PT

    1989-12-01

    Full Text Available The first edition of a bibliography of fynbos ecology was produced in 1981 and comprised 814 references to work completed or commenced prior to the initiation of the Fynbos Biome Project. It is appropriate that this second edition...

  20. The Star Wars franchise, fan edits, and Lucasfilm [symposium

    Directory of Open Access Journals (Sweden)

    Forrest Phillips

    2012-03-01

    Full Text Available Fan edits assert that fan authority is on par with that of a work's original creator; this authority is generated not only through the argument, but through the structure of the text itself. Fan edits adhere to classical filmmaking techniques, creating coherent plots and editing for continuity. These recut texts are emblematic of current ownership debates; they are the read/write culture brought to fandom. The Star Wars series of films are among the most frequently recut texts and are my focus here.

  1. Dirac gauginos, gauge mediation and unification

    Energy Technology Data Exchange (ETDEWEB)

    Benakli, K. [UPMC Univ. Paris 06 (France). Laboratoire de Physique Theorique et Hautes Energies, CNRS; Goodsell, M.D. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2010-03-15

    We investigate the building of models with Dirac gauginos and perturbative gauge coupling unification. Here, in contrast to the MSSM, additional fields are required for unification, and these can naturally play the role of the messengers of supersymmetry breaking. We present a framework within which such models can be constructed, including the constraints that the messenger sector must satisfy; and the renormalisation group equations for the soft parameters, which differ from those of the MSSM. For illustration, we provide the spectrum at the electroweak scale for explicit models whose gauge couplings unify at the scale predicted by heterotic strings. (orig.)

  2. Dirac Gauginos, Gauge Mediation and Unification

    CERN Document Server

    Benakli, K

    2010-01-01

    We investigate the building of models with Dirac gauginos and perturbative gauge coupling unification. Here, in contrast to the MSSM, additional fields are required for unification, and these can naturally play the role of the messengers of supersymmetry breaking. We present a framework within which such models can be constructed, including the constraints that the messenger sector must satisfy; and the renormalisation group equations for the soft parameters, which differ from those of the MSSM. For illustration, we provide the spectrum at the electroweak scale for explicit models whose gauge couplings unify at the scale predicted by heterotic strings.

  3. Dirac gauginos, gauge mediation and unification

    International Nuclear Information System (INIS)

    Benakli, K.

    2010-03-01

    We investigate the building of models with Dirac gauginos and perturbative gauge coupling unification. Here, in contrast to the MSSM, additional fields are required for unification, and these can naturally play the role of the messengers of supersymmetry breaking. We present a framework within which such models can be constructed, including the constraints that the messenger sector must satisfy; and the renormalisation group equations for the soft parameters, which differ from those of the MSSM. For illustration, we provide the spectrum at the electroweak scale for explicit models whose gauge couplings unify at the scale predicted by heterotic strings. (orig.)

  4. Logarithmic unification from symmetries enhanced in the sub-millimeter infrared

    International Nuclear Information System (INIS)

    Arkani-Hamed, Nima; Dimopoulos, Savas; March-Russell, John

    1999-01-01

    In theories with TeV string scale and sub-millimeter extra dimensions the attractive picture of logarithmic gauge coupling unification at 10 16 GeV is seemingly destroyed. In this paper we argue to the contrary that logarithmic unification can occur in such theories. The rationale for unification is no longer that a gauge symmetry is restored at short distances, but rather that a geometric symmetry is restored at large distances in the bulk away from our 3-brane. The apparent ''running'' of the gauge couplings to energies far above the string scale actually arises from the logarithmic variation of classical fields in (sets of) two large transverse dimensions. We present a number of N = 2 and N = 1 supersymmetric D-brane constructions illustrating this picture for unification

  5. Translational semantics: A discussion of the second edition of ...

    African Journals Online (AJOL)

    Translational semantics: A discussion of the second edition of Geoffrey Leech's Semantics: the Study of Meaning. N Love. Abstract. No abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.5774/11-0-106 · AJOL African Journals ...

  6. MindEdit: A P300-based text editor for mobile devices.

    Science.gov (United States)

    Elsawy, Amr S; Eldawlatly, Seif; Taher, Mohamed; Aly, Gamal M

    2017-01-01

    Practical application of Brain-Computer Interfaces (BCIs) requires that the whole BCI system be portable. The mobility of BCI systems involves two aspects: making the electroencephalography (EEG) recording devices portable, and developing software applications with low computational complexity to be able to run on low computational-power devices such as tablets and smartphones. This paper addresses the development of MindEdit; a P300-based text editor for Android-based devices. Given the limited resources of mobile devices and their limited computational power, a novel ensemble classifier is utilized that uses Principal Component Analysis (PCA) features to identify P300 evoked potentials from EEG recordings. PCA computations in the proposed method are channel-based as opposed to concatenating all channels as in traditional feature extraction methods; thus, this method has less computational complexity compared to traditional P300 detection methods. The performance of the method is demonstrated on data recorded from MindEdit on an Android tablet using the Emotiv wireless neuroheadset. Results demonstrate the capability of the introduced PCA ensemble classifier to classify P300 data with maximum average accuracy of 78.37±16.09% for cross-validation data and 77.5±19.69% for online test data using only 10 trials per symbol and a 33-character training dataset. Our analysis indicates that the introduced method outperforms traditional feature extraction methods. For a faster operation of MindEdit, a variable number of trials scheme is introduced that resulted in an online average accuracy of 64.17±19.6% and a maximum bitrate of 6.25bit/min. These results demonstrate the efficacy of using the developed BCI application with mobile devices. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Low energy implications of minimal superstring unification

    International Nuclear Information System (INIS)

    Khalil, S.; Vissani, F.; Masiero, A.

    1995-11-01

    We study the phenomenological implications of effective supergravities based on string vacua with spontaneously broken N =1 supersymmetry by dilation and moduli F-terms. We further require Minimal String Unification, namely that large string threshold corrections ensure the correct unification of the gauge couplings at the grand unification scale. The whole supersymmetric mass spectrum turns out to be determined in terms of only two independent parameters, the dilaton-moduli mixing angle and the gravitino mass. In particular we discuss the region of the parameter space where at least one superpartner is ''visible'' at LEPII. We find that the most likely candidates are the scalar partner of the right-handed electron and the lightest chargino, with interesting correlations between their masses and with the mass of the lightest higgs. We show how discovering SUSY particles at LEPII might rather sharply discriminate between scenarios with pure dilaton SUSY breaking and mixed dilaton-moduli breaking. (author). 10 refs, 7 figs

  8. Operational Transformation In Co-Operative Editing

    Directory of Open Access Journals (Sweden)

    Mandeep Kaur

    2015-08-01

    Full Text Available Cooperative Editing Systems in real-time allows a virtual team to view and edit a shared document at the same time. The document shared must be synchronized in order to ensure consistency for all the participants. This paper describes the Operational Transformation the evolution of its techniques its various applications major issues and achievements. In addition this paper will present working of a platform where two users can edit a code programming file at the same time.

  9. RNA Editing and Drug Discovery for Cancer Therapy

    Directory of Open Access Journals (Sweden)

    Wei-Hsuan Huang

    2013-01-01

    Full Text Available RNA editing is vital to provide the RNA and protein complexity to regulate the gene expression. Correct RNA editing maintains the cell function and organism development. Imbalance of the RNA editing machinery may lead to diseases and cancers. Recently, RNA editing has been recognized as a target for drug discovery although few studies targeting RNA editing for disease and cancer therapy were reported in the field of natural products. Therefore, RNA editing may be a potential target for therapeutic natural products. In this review, we provide a literature overview of the biological functions of RNA editing on gene expression, diseases, cancers, and drugs. The bioinformatics resources of RNA editing were also summarized.

  10. Unification of Patrimonial Laws Governing International Trade

    DEFF Research Database (Denmark)

    Lando, Ole

    2016-01-01

    Should the laws of the world dealing with cross-border transactions be unified? Such unification presupposes an agreement on what we understand by ‘law’ and what its sources are. The drafters of uniform laws and lawyers who are preoccupied with comparative law often ask themselves: Is there, among...... the nations, a common core of legal values? If there is, this will facilitate legal unification. It will also make the international law-making easier if, in exceptional cases, a court is permitted to disregard a legal rule....

  11. Dark Matter in SuperGUT Unification Models

    International Nuclear Information System (INIS)

    Olive, Keith A

    2011-01-01

    After a brief update on the prospects for dark matter in the constrained version of the MSSM (CMSSM) and its differences with models based on minimal supergravity (mSUGRA), I will consider the effects of unifying the supersymmetry-breaking parameters at a scale above M GUT . One of the consequences of superGUT unification, is the ability to take vanishing scalar masses at the unification scale with a neutralino LSP dark matter candidate. This allows one to resurrect no-scale supergravity as a viable phenomenological model.

  12. Elementary particles and physics interaction unification

    International Nuclear Information System (INIS)

    Leite-Lopes, J.

    1985-01-01

    Quantum theory and relativity theory are fundamental of relativistic quantum mechanics, quantum field theory, which is the base of elementary particle physics, gauge field theory and basic force unification models. After a short introduction of relativistic equations of the main fields, the free scalar field, the free vector field, the free electromagnetic field and the free spinor field, and of elementary particles and basic interactions, gauge invariance and electromagnetic gauge field are detailed. Then the presentation of internal degrees of freedom, especially isospin, introduces gauge field theory of Yang-Mills. At last weak interactions and strong interactions are presented and lead to grand unification theory in conclusion [fr

  13. Layout-aware text extraction from full-text PDF of scientific articles

    Directory of Open Access Journals (Sweden)

    Ramakrishnan Cartic

    2012-05-01

    Full Text Available Abstract Background The Portable Document Format (PDF is the most commonly used file format for online scientific publications. The absence of effective means to extract text from these PDF files in a layout-aware manner presents a significant challenge for developers of biomedical text mining or biocuration informatics systems that use published literature as an information source. In this paper we introduce the ‘Layout-Aware PDF Text Extraction’ (LA-PDFText system to facilitate accurate extraction of text from PDF files of research articles for use in text mining applications. Results Our paper describes the construction and performance of an open source system that extracts text blocks from PDF-formatted full-text research articles and classifies them into logical units based on rules that characterize specific sections. The LA-PDFText system focuses only on the textual content of the research articles and is meant as a baseline for further experiments into more advanced extraction methods that handle multi-modal content, such as images and graphs. The system works in a three-stage process: (1 Detecting contiguous text blocks using spatial layout processing to locate and identify blocks of contiguous text, (2 Classifying text blocks into rhetorical categories using a rule-based method and (3 Stitching classified text blocks together in the correct order resulting in the extraction of text from section-wise grouped blocks. We show that our system can identify text blocks and classify them into rhetorical categories with Precision1 = 0.96% Recall = 0.89% and F1 = 0.91%. We also present an evaluation of the accuracy of the block detection algorithm used in step 2. Additionally, we have compared the accuracy of the text extracted by LA-PDFText to the text from the Open Access subset of PubMed Central. We then compared this accuracy with that of the text extracted by the PDF2Text system, 2commonly used to extract text from PDF

  14. An Ordering Linear Unification Algorithm

    Institute of Scientific and Technical Information of China (English)

    胡运发

    1989-01-01

    In this paper,we present an ordering linear unification algorithm(OLU).A new idea on substituteion of the binding terms is introduced to the algorithm,which is able to overcome some drawbacks of other algorithms,e.g.,MM algorithm[1],RG1 and RG2 algorithms[2],Particularly,if we use the directed eyclie graphs,the algoritm needs not check the binding order,then the OLU algorithm can also be aplied to the infinite tree data struceture,and a higher efficiency can be expected.The paper focuses upon the discussion of OLU algorithm and a partial order structure with respect to the unification algorithm.This algorithm has been implemented in the GKD-PROLOG/VAX 780 interpreting system.Experimental results have shown that the algorithm is very simple and efficient.

  15. Genes (including RNA editing information) - RMG | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available t tested T: transcribed N: not transcribed Editing site Editing site N: not transcribed Previous reports on ...editing sites Previous reports on editing sites Strand Strand S: sense A: antisense exon1 start Start positi

  16. Einstein's dream : the space-time unification of fundamental forces

    Energy Technology Data Exchange (ETDEWEB)

    Salam, A [International Centre for Theoretical Physics, Trieste (Italy)

    1981-06-01

    The historical developments in physics which started with Galileo in the 11th century, Newton in the 17 century, culminated in the unification of space-time by Einstein in this century are traced. The theories put forward by Einstein himself and by subsequent workers in the field after him, regarding the unification of all basic forces of nature (i.e.) the electromagnetic and the gravitational ones and the weak and strong nuclear forces are discussed. The experiments being conducted in Kolar and other places to detect a heavier photon which would be a positive proof of the validity of the unification theory, are touched upon. The possible application of this concept even in industry has been pointed out.

  17. Gauge Coupling Unification with Partly Composite Matter

    International Nuclear Information System (INIS)

    Gherghetta, Tony

    2005-01-01

    It is shown how gauge coupling unification can occur in models with partly composite matter. The particle states which are composite only contribute small logarithmns to the running of gauge couplings, while the elementary states contribute the usual large logarithmns. This introduces a new differential running contribution to the gauge couplings from partly composite SU(5) matter multiplets. In particular, for partly supersymmetric models, the incomplete SU(5) elementary matter multiplets restore gauge coupling unification even though the usual elementary gaugino and Higgsino contributions need not be present

  18. Unification and geometrization of physics in the cosmological context

    International Nuclear Information System (INIS)

    Heller, M.; Watykanskie Obserwatorium Astronomiczne, Vatican

    1991-01-01

    Einstein belived that a good physical theory should posses an ''inner perfection''. Trace the inner perfection of the present gauge theories by contemplating their geometric structures (in terms of fibre bundles). The search for the ultimate symmetry of the unification of physics unavoidably leads to the unification of physics and cosmology. 4 figs., 23 refs. (author)

  19. Revisiting top-bottom-tau Yukawa unification in supersymmetric grand unified theories

    International Nuclear Information System (INIS)

    Tobe, Kazuhiro; Wells, James D.

    2003-01-01

    Third family Yukawa unification, as suggested by minimal SO(10) unification, is revisited in light of recent experimental measurements and theoretical progress. We characterize unification in a semi-model-independent fashion, and conclude that finite b quark mass corrections from superpartners must be non-zero, but much smaller than naively would be expected. We show that a solution that does not require cancellations of dangerously large tanβ effects in observables implies that scalar superpartner masses should be substantially heavier than the Z scale, and perhaps inaccessible to all currently approved colliders. On the other hand, gauginos must be significantly lighter than the scalars. We demonstrate that a spectrum of anomaly-mediated gaugino masses and heavy scalars works well as a theory compatible with third family Yukawa unification and dark matter observations

  20. Problems in unification and supergravity

    International Nuclear Information System (INIS)

    Farrar, G.; Henyey, F.

    1984-01-01

    Problems in unification of the various gauge groups, quantum gravity, supersymmetry and supergravity, compact dimensions of space-time, and conditions at the beginning of the universe are discussed. Separate entries were prepared for the data base for the 15 papers presented

  1. Prospects for further unification

    International Nuclear Information System (INIS)

    Ne'eman, Y.

    1983-07-01

    We review the unification of weak and electromagnetic interactions (QAD), the prevalent color gauge theory of the strong interactions (QCD) and attempts to embed both these theories in a further Unified Gauge Theory. We discuss the related advances in cosmology and touch upon other approaches to the understanding of particles and fields. 44 references

  2. Is searching full text more effective than searching abstracts?

    Directory of Open Access Journals (Sweden)

    Lin Jimmy

    2009-02-01

    Full Text Available Abstract Background With the growing availability of full-text articles online, scientists and other consumers of the life sciences literature now have the ability to go beyond searching bibliographic records (title, abstract, metadata to directly access full-text content. Motivated by this emerging trend, I posed the following question: is searching full text more effective than searching abstracts? This question is answered by comparing text retrieval algorithms on MEDLINE® abstracts, full-text articles, and spans (paragraphs within full-text articles using data from the TREC 2007 genomics track evaluation. Two retrieval models are examined: bm25 and the ranking algorithm implemented in the open-source Lucene search engine. Results Experiments show that treating an entire article as an indexing unit does not consistently yield higher effectiveness compared to abstract-only search. However, retrieval based on spans, or paragraphs-sized segments of full-text articles, consistently outperforms abstract-only search. Results suggest that highest overall effectiveness may be achieved by combining evidence from spans and full articles. Conclusion Users searching full text are more likely to find relevant articles than searching only abstracts. This finding affirms the value of full text collections for text retrieval and provides a starting point for future work in exploring algorithms that take advantage of rapidly-growing digital archives. Experimental results also highlight the need to develop distributed text retrieval algorithms, since full-text articles are significantly longer than abstracts and may require the computational resources of multiple machines in a cluster. The MapReduce programming model provides a convenient framework for organizing such computations.

  3. Problems in unification and supergravity

    Energy Technology Data Exchange (ETDEWEB)

    Farrar, G.; Henyey, F. (eds.)

    1984-01-01

    Problems in unification of the various gauge groups, quantum gravity, supersymmetry and supergravity, compact dimensions of space-time, and conditions at the beginning of the universe are discussed. Separate entries were prepared for the data base for the 15 papers presented. (WHK)

  4. Selected topics in grand unification

    International Nuclear Information System (INIS)

    Seckel, D.

    1983-01-01

    This dissertation is a collection of four pieces of research dealing with grand unification. The topics are neutron oscillation, CP violation, magnetic monopole abundance and distribution in neutron stars, and a proposal for an inflationary cosmology driven by stress-energy in domain walls

  5. Multilingual access to full text databases

    International Nuclear Information System (INIS)

    Fluhr, C.; Radwan, K.

    1990-05-01

    Many full text databases are available in only one language, or more, they may contain documents in different languages. Even if the user is able to understand the language of the documents in the database, it could be easier for him to express his need in his own language. For the case of databases containing documents in different languages, it is more simple to formulate the query in one language only and to retrieve documents in different languages. This paper present the developments and the first experiments of multilingual search, applied to french-english pair, for text data in nuclear field, based on the system SPIRIT. After reminding the general problems of full text databases search by queries formulated in natural language, we present the methods used to reformulate the queries and show how they can be expanded for multilingual search. The first results on data in nuclear field are presented (AFCEN norms and INIS abstracts). 4 refs

  6. Is searching full text more effective than searching abstracts?

    Science.gov (United States)

    Lin, Jimmy

    2009-02-03

    With the growing availability of full-text articles online, scientists and other consumers of the life sciences literature now have the ability to go beyond searching bibliographic records (title, abstract, metadata) to directly access full-text content. Motivated by this emerging trend, I posed the following question: is searching full text more effective than searching abstracts? This question is answered by comparing text retrieval algorithms on MEDLINE abstracts, full-text articles, and spans (paragraphs) within full-text articles using data from the TREC 2007 genomics track evaluation. Two retrieval models are examined: bm25 and the ranking algorithm implemented in the open-source Lucene search engine. Experiments show that treating an entire article as an indexing unit does not consistently yield higher effectiveness compared to abstract-only search. However, retrieval based on spans, or paragraphs-sized segments of full-text articles, consistently outperforms abstract-only search. Results suggest that highest overall effectiveness may be achieved by combining evidence from spans and full articles. Users searching full text are more likely to find relevant articles than searching only abstracts. This finding affirms the value of full text collections for text retrieval and provides a starting point for future work in exploring algorithms that take advantage of rapidly-growing digital archives. Experimental results also highlight the need to develop distributed text retrieval algorithms, since full-text articles are significantly longer than abstracts and may require the computational resources of multiple machines in a cluster. The MapReduce programming model provides a convenient framework for organizing such computations.

  7. The Economic Implications of Korean Unification

    National Research Council Canada - National Science Library

    Schmitz, Jonathan

    2002-01-01

    .... To lessen this burden, South Korea will need to initiate policy reforms that can ease the financial stress and repercussions of unification and create an integrated economic community with North Korea...

  8. Mining biological networks from full-text articles.

    Science.gov (United States)

    Czarnecki, Jan; Shepherd, Adrian J

    2014-01-01

    The study of biological networks is playing an increasingly important role in the life sciences. Many different kinds of biological system can be modelled as networks; perhaps the most important examples are protein-protein interaction (PPI) networks, metabolic pathways, gene regulatory networks, and signalling networks. Although much useful information is easily accessible in publicly databases, a lot of extra relevant data lies scattered in numerous published papers. Hence there is a pressing need for automated text-mining methods capable of extracting such information from full-text articles. Here we present practical guidelines for constructing a text-mining pipeline from existing code and software components capable of extracting PPI networks from full-text articles. This approach can be adapted to tackle other types of biological network.

  9. Genome editing: progress and challenges for medical applications

    Directory of Open Access Journals (Sweden)

    Dana Carroll

    2016-11-01

    Full Text Available Editorial summary The development of the CRISPR-Cas platform for genome editing has greatly simplified the process of making targeted genetic modifications. Applications of genome editing are expected to have a substantial impact on human therapies through the development of better animal models, new target discovery, and direct therapeutic intervention.

  10. ARCHITECTURE E-MALL USING RUP (RATIONAL UNIFED PROCESS METHODS

    Directory of Open Access Journals (Sweden)

    Atin Triwahyuni

    2016-09-01

    Full Text Available Sistem Informasi dan teknologi saat ini telah berkembang dengan cepat dan memberikan dampak kedalam semua aspek kehidupan. Kebutuhan akan sistem informasi yang didukung dengan teknologi mulai dirasakan oleh berbagai kalangan masyarakat, salah satunya adalah kalangan masyarakat yang bergerak di dunia bisnis dan usaha, dengan memanfaatkan teknologi, setiap orang yang bergerak di dunia usaha dapat memperkenalkan produk mereka dengan menggunakan media internet, sehingga dapat meningkatkan penjualan dan memperluas pemasarannya, sedangkan pada media penjualan dagangan yang dijajakan masih secara konvensional, yaitu langsung bertatap muka dengan pelanggan untuk melihat maupun melakukan pembelian produk, dimana pelanggan terlebih dahulu menuju toko yang diinginkan, tapi dengan adanya sebuah website E-Mall ini, pelanggan bisa menemukan apa yang dicari tanpa harus mengunjungi toko tersebut. Metode yang digunakan dalam penelitian ini adalah metode RUP (Rational Unifed Process yang menggunakan konsep object oriented, dengan aktifitas yang berfokus pada pengembangan model dengan menggunakan Unified Model Language (UML. Penelitian yang telah dilakukan menghasilkan sebuah website yang dapat membantu dalam bisnis perdagangan pakaian online.

  11. Unification of gauge couplings in radiative neutrino mass models

    DEFF Research Database (Denmark)

    Hagedorn, Claudia; Ohlsson, Tommy; Riad, Stella

    2016-01-01

    masses at one-loop level and (III) models with particles in the adjoint representation of SU(3). In class (I), gauge couplings unify in a few models and adding dark matter amplifies the chances for unification. In class (II), about a quarter of the models admits gauge coupling unification. In class (III......We investigate the possibility of gauge coupling unification in various radiative neutrino mass models, which generate neutrino masses at one- and/or two-loop level. Renormalization group running of gauge couplings is performed analytically and numerically at one- and two-loop order, respectively....... We study three representative classes of radiative neutrino mass models: (I) minimal ultraviolet completions of the dimension-7 ΔL = 2 operators which generate neutrino masses at one- and/or two-loop level without and with dark matter candidates, (II) models with dark matter which lead to neutrino...

  12. Layout-aware text extraction from full-text PDF of scientific articles.

    Science.gov (United States)

    Ramakrishnan, Cartic; Patnia, Abhishek; Hovy, Eduard; Burns, Gully Apc

    2012-05-28

    The Portable Document Format (PDF) is the most commonly used file format for online scientific publications. The absence of effective means to extract text from these PDF files in a layout-aware manner presents a significant challenge for developers of biomedical text mining or biocuration informatics systems that use published literature as an information source. In this paper we introduce the 'Layout-Aware PDF Text Extraction' (LA-PDFText) system to facilitate accurate extraction of text from PDF files of research articles for use in text mining applications. Our paper describes the construction and performance of an open source system that extracts text blocks from PDF-formatted full-text research articles and classifies them into logical units based on rules that characterize specific sections. The LA-PDFText system focuses only on the textual content of the research articles and is meant as a baseline for further experiments into more advanced extraction methods that handle multi-modal content, such as images and graphs. The system works in a three-stage process: (1) Detecting contiguous text blocks using spatial layout processing to locate and identify blocks of contiguous text, (2) Classifying text blocks into rhetorical categories using a rule-based method and (3) Stitching classified text blocks together in the correct order resulting in the extraction of text from section-wise grouped blocks. We show that our system can identify text blocks and classify them into rhetorical categories with Precision1 = 0.96% Recall = 0.89% and F1 = 0.91%. We also present an evaluation of the accuracy of the block detection algorithm used in step 2. Additionally, we have compared the accuracy of the text extracted by LA-PDFText to the text from the Open Access subset of PubMed Central. We then compared this accuracy with that of the text extracted by the PDF2Text system, 2commonly used to extract text from PDF. Finally, we discuss preliminary error analysis for

  13. 48 CFR 2852.102-270 - Incorporation in full text.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Incorporation in full text... 2852.102-270 Incorporation in full text. JAR provisions or clauses shall be incorporated in solicitations and contracts in full text. ...

  14. 48 CFR 1952.102-2 - Incorporation in full text.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Incorporation in full text... Clauses 1952.102-2 Incorporation in full text. All IAAR provisions and clauses shall be incorporated in solicitations and/or contracts in full text. ...

  15. Preface to Special Edition

    Directory of Open Access Journals (Sweden)

    Renee Nathanson

    2012-04-01

    Full Text Available Given that reading comprehension is at the forefront of global literacy discourse, this special edition of Per Linguam, the first number that is also published online, features a collection of articles that cover different aspects of reading comprehension and instruction, such as, strategies for comprehending texts, metacognitive awareness, the reciprocity of assessment and comprehension instruction and socio-affective factors that influence comprehension.

  16. Tracking Amendments to Legislation and Other Political Texts with a Novel Minimum-Edit-Distance Algorithm: DocuToads

    DEFF Research Database (Denmark)

    Hermansson, Henrik Alf Jonas; Cross, James

    2015-01-01

    Political scientists often nd themselves tracking amendments to political texts. As different actors weigh in, texts change as they are drafted and redrafted, reflecting political preferences and power. This study provides a novel solution to the problem of detecting amendments to political text......) and substantive amount of amendments made between version of texts. To illustrate the usefulness and eciency of the approach we replicate two existing studies from the field of legislative studies. Our results demonstrate that minimum edit distance methods can produce superior measures of text amendments to hand...

  17. From chaos to unification: U theory vs. M theory

    International Nuclear Information System (INIS)

    Ye, Fred Y.

    2009-01-01

    A unified physical theory called U theory, that is different from M theory, is defined and characterized. U theory, which includes spinor and twistor theory, loop quantum gravity, causal dynamical triangulations, E-infinity unification theory, and Clifford-Finslerian unifications, is based on physical tradition and experimental foundations. In contrast, M theory pays more attention to mathematical forms. While M theory is characterized by supersymmetry string theory, U theory is characterized by non-supersymmetry unified field theory.

  18. Ebola virus RNA editing depends on the primary editing site sequence and an upstream secondary structure.

    Directory of Open Access Journals (Sweden)

    Masfique Mehedi

    Full Text Available Ebolavirus (EBOV, the causative agent of a severe hemorrhagic fever and a biosafety level 4 pathogen, increases its genome coding capacity by producing multiple transcripts encoding for structural and nonstructural glycoproteins from a single gene. This is achieved through RNA editing, during which non-template adenosine residues are incorporated into the EBOV mRNAs at an editing site encoding for 7 adenosine residues. However, the mechanism of EBOV RNA editing is currently not understood. In this study, we report for the first time that minigenomes containing the glycoprotein gene editing site can undergo RNA editing, thereby eliminating the requirement for a biosafety level 4 laboratory to study EBOV RNA editing. Using a newly developed dual-reporter minigenome, we have characterized the mechanism of EBOV RNA editing, and have identified cis-acting sequences that are required for editing, located between 9 nt upstream and 9 nt downstream of the editing site. Moreover, we show that a secondary structure in the upstream cis-acting sequence plays an important role in RNA editing. EBOV RNA editing is glycoprotein gene-specific, as a stretch encoding for 7 adenosine residues located in the viral polymerase gene did not serve as an editing site, most likely due to an absence of the necessary cis-acting sequences. Finally, the EBOV protein VP30 was identified as a trans-acting factor for RNA editing, constituting a novel function for this protein. Overall, our results provide novel insights into the RNA editing mechanism of EBOV, further understanding of which might result in novel intervention strategies against this viral pathogen.

  19. Direct Visual Editing of Node Attributes in Graphs

    Directory of Open Access Journals (Sweden)

    Christian Eichner

    2016-10-01

    Full Text Available There are many expressive visualization techniques for analyzing graphs. Yet, there is only little research on how existing visual representations can be employed to support data editing. An increasingly relevant task when working with graphs is the editing of node attributes. We propose an integrated visualize-and-edit approach to editing attribute values via direct interaction with the visual representation. The visualize part is based on node-link diagrams paired with attribute-dependent layouts. The edit part is as easy as moving nodes via drag-and-drop gestures. We present dedicated interaction techniques for editing quantitative as well as qualitative attribute data values. The benefit of our novel integrated approach is that one can directly edit the data while the visualization constantly provides feedback on the implications of the data modifications. Preliminary user feedback indicates that our integrated approach can be a useful complement to standard non-visual editing via external tools.

  20. Selecting Full-Text Undergraduate Periodicals Databases.

    Science.gov (United States)

    Still, Julie M.; Kassabian, Vibiana

    1999-01-01

    Examines how libraries and librarians can compare full-text general periodical indices, using ProQuest Direct, Periodical Abstracts (via Ovid), and EBSCOhost as examples. Explores breadth and depth of coverage; manipulation of results (email/download/print); ease of use (searching); and indexing quirks. (AEF)

  1. Gauge coupling unification in six dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Lee, H.M. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)]|[Carnegie-Mellon Univ., Pittsburgh, PA (United States). Dept. of Physics

    2006-11-15

    We compute the one-loop gauge couplings in six-dimensional non-Abelian gauge theories on the T{sup 2}/Z{sub 2} orbifold with general GUT breaking boundary conditions. For concreteness, we apply the obtained general formulae to the gauge coupling running in a 6D SO(10) orbifold GUT where the GUT group is broken down to the standard model gauge group up to an extra U(1). We find that the one-loop corrections depend on the parity matrices encoding the orbifold boundary conditions as well as the volume and shape moduli of extra dimensions. When the U(1) is broken by the VEV of bulk singlets, the accompanying extra color triplets also affect the unification of the gauge couplings. In this case, the B-L breaking scale is closely linked to the compactification scales for maintaining a success of the gauge coupling unification. (orig.)

  2. Precision LEP data, supersymmetric GUTs and string unification

    International Nuclear Information System (INIS)

    Ellis, J.; Kelley, S.; Nanopoulos, D.V.; Houston Area Research Center

    1990-01-01

    The precision of sin 2 θ w MS (m Z ) extracted from LEP data (0.233±0.001) confirms the prediction of minimal supersymmetric GUTs (0.235±0.004) within the errors of about 2%. Moreover, supersymmetric GUTs with three generations and a heavy top quark also predict m b =5.2±0.3 GeV in perfect agreement with potential model estimates (5.0±0.2 GeV). String unification would require that the effective grand unification scale m GUT be no larger than the effective string unification scale m SU , which is indeed consistent with the LEP data, which indicate m GUT ≅ 2x10 16 GeV in a minimal supersymmetric GUT, compared with the theoretical estimate m SU ≅ 10 17 GeV. Specific choices of the string model moduli could enforce m GUT =m SU even in minimal supersymmetric GUTs, whilst non-minimal supersymmetric GUTs can reconcile the successful predictions of sin 2 θ w with m GUT = m SU for generic values of the moduli, but tend to have m b too large. (orig.)

  3. Introduction to grand unification theories

    International Nuclear Information System (INIS)

    Kang, Kyungsik

    1980-01-01

    We introduce the Georgi-Glashow model based on the minimal gauge group SU(5) as a prototype grand unification theory of the electroweak and strong interactions. Simple estimation of sin 2 thetasub(W) in the symmetry limit and the renormalization corrections at the energy scale of Msub(W) are given along wich other successes of the SU(5) model

  4. Understanding Editing Behaviors in Multilingual Wikipedia.

    Directory of Open Access Journals (Sweden)

    Suin Kim

    Full Text Available Multilingualism is common offline, but we have a more limited understanding of the ways multilingualism is displayed online and the roles that multilinguals play in the spread of content between speakers of different languages. We take a computational approach to studying multilingualism using one of the largest user-generated content platforms, Wikipedia. We study multilingualism by collecting and analyzing a large dataset of the content written by multilingual editors of the English, German, and Spanish editions of Wikipedia. This dataset contains over two million paragraphs edited by over 15,000 multilingual users from July 8 to August 9, 2013. We analyze these multilingual editors in terms of their engagement, interests, and language proficiency in their primary and non-primary (secondary languages and find that the English edition of Wikipedia displays different dynamics from the Spanish and German editions. Users primarily editing the Spanish and German editions make more complex edits than users who edit these editions as a second language. In contrast, users editing the English edition as a second language make edits that are just as complex as the edits by users who primarily edit the English edition. In this way, English serves a special role bringing together content written by multilinguals from many language editions. Nonetheless, language remains a formidable hurdle to the spread of content: we find evidence for a complexity barrier whereby editors are less likely to edit complex content in a second language. In addition, we find that multilinguals are less engaged and show lower levels of language proficiency in their second languages. We also examine the topical interests of multilingual editors and find that there is no significant difference between primary and non-primary editors in each language.

  5. Model-based object classification using unification grammars and abstract representations

    Science.gov (United States)

    Liburdy, Kathleen A.; Schalkoff, Robert J.

    1993-04-01

    The design and implementation of a high level computer vision system which performs object classification is described. General object labelling and functional analysis require models of classes which display a wide range of geometric variations. A large representational gap exists between abstract criteria such as `graspable' and current geometric image descriptions. The vision system developed and described in this work addresses this problem and implements solutions based on a fusion of semantics, unification, and formal language theory. Object models are represented using unification grammars, which provide a framework for the integration of structure and semantics. A methodology for the derivation of symbolic image descriptions capable of interacting with the grammar-based models is described and implemented. A unification-based parser developed for this system achieves object classification by determining if the symbolic image description can be unified with the abstract criteria of an object model. Future research directions are indicated.

  6. Fundamental Elements and Interactions of Nature: A Classical Unification Theory

    Directory of Open Access Journals (Sweden)

    Tianxi Zhang

    2010-04-01

    Full Text Available A classical unification theory that completely unifies all the fundamental interactions of nature is developed. First, the nature is suggested to be composed of the following four fundamental elements: mass, radiation, electric charge, and color charge. All known types of matter or particles are a combination of one or more of the four fundamental elements. Photons are radiation; neutrons have only mass; protons have both mass and electric charge; and quarks contain mass, electric charge, and color charge. The nature fundamental interactions are interactions among these nature fundamental elements. Mass and radiation are two forms of real energy. Electric and color charges are considered as two forms of imaginary energy. All the fundamental interactions of nature are therefore unified as a single interaction between complex energies. The interaction between real energies is the gravitational force, which has three types: mass-mass, mass-radiation, and radiation-radiation interactions. Calculating the work done by the mass-radiation interaction on a photon derives the Einsteinian gravitational redshift. Calculating the work done on a photon by the radiation-radiation interaction derives a radiation redshift, which is much smaller than the gravitational redshift. The interaction between imaginary energies is the electromagnetic (between electric charges, weak (between electric and color charges, and strong (between color charges interactions. In addition, we have four imaginary forces between real and imaginary energies, which are mass-electric charge, radiation-electric charge, mass-color charge, and radiation-color charge interactions. Among the four fundamental elements, there are ten (six real and four imaginary fundamental interactions. This classical unification theory deepens our understanding of the nature fundamental elements and interactions, develops a new concept of imaginary energy for electric and color charges, and provides a

  7. Fundamental Elements and Interactions of Nature: A Classical Unification Theory

    Directory of Open Access Journals (Sweden)

    Zhang T. X.

    2010-04-01

    Full Text Available A classical unification theory that completely unifies all the fundamental interactions of nature is developed. First, the nature is suggested to be composed of the following four fundamental elements: mass, radiation, electric charge, and color charge. All known types of matter or particles are a combination of one or more of the four fundamental elements. Photons are radiation; neutrons have only mass; protons have both mass and electric charge; and quarks contain mass, electric charge, and color charge. The nature fundamental interactions are interactions among these nature fundamental elements. Mass and radiation are two forms of real energy. Electric and color charges are con- sidered as two forms of imaginary energy. All the fundamental interactions of nature are therefore unified as a single interaction between complex energies. The interac- tion between real energies is the gravitational force, which has three types: mass-mass, mass-radiation, and radiation-radiation interactions. Calculating the work done by the mass-radiation interaction on a photon derives the Einsteinian gravitational redshift. Calculating the work done on a photon by the radiation-radiation interaction derives a radiation redshift, which is much smaller than the gravitational redshift. The interaction between imaginary energies is the electromagnetic (between electric charges, weak (between electric and color charges, and strong (between color charges interactions. In addition, we have four imaginary forces between real and imaginary energies, which are mass-electric charge, radiation-electric charge, mass-color charge, and radiation- color charge interactions. Among the four fundamental elements, there are ten (six real and four imaginary fundamental interactions. This classical unification theory deep- ens our understanding of the nature fundamental elements and interactions, develops a new concept of imaginary energy for electric and color charges, and provides a

  8. On the Issue of the Unification of Norms on Jurisdiction in the Field of Civil Proceedings Within the European Union

    Directory of Open Access Journals (Sweden)

    Elena V. Maystrovich

    2016-12-01

    Full Text Available In this article author examines some issues of norms on jurisdiction unification in the field of civil proceedings within the European Union. Author emphasizes that as a result of the adoption of the new Regulation No. 1215/2012 "Brussels Ibis", which came into force in 2012, rules on jurisdiction in the field of civil proceedings have undergone a number of changes. Article deals with the draft of the proposed amendments and their practical implementation. Amendments, their significance, efficiency and correlation with the projected initially are analyzed.

  9. Probes of Yukawa unification in supersymmetric SO(10) models

    Energy Technology Data Exchange (ETDEWEB)

    Westhoff, Susanne

    2009-10-23

    This work is composed as follows: In Chapter 1, the disposed reader is made familiar with the foundations of flavourphysics and Grand Unification, including group-theoretical aspects of SO(10). In Chapter 2, we introduce a specific supersymmetric GUT model based on SO(10) and designed to probe down-quark-lepton Yukawa unification. Within this framework we explore the effects of large atmospheric neutrino mixing in bottom-strange transitions on the mass difference and CP phase in B{sub s}- anti B{sub s} meson mixing. Chapter 3 is devoted to corrections to Yukawa unification. We derive constraints on Yukawa corrections for light fermions from K- anti K and B{sub d}- anti B {sub d} mixing. As an application we study implications of neutrino mixing effects in CP-violating K and B{sub d} observables on the unitrity triangle. Finally, in Chapter 4, we discuss effects of large tan {beta} in B{yields}(D){tau}{nu} decays with respect to their potential to discover charged Higgs bosons and to discriminate between different GUT models of flavour.

  10. Gauge unification of fundamental forces

    International Nuclear Information System (INIS)

    Salam, A.

    1980-02-01

    After having reviewed briefly the last twenty years' progress in the theory of unification, with the twin aspects of development of a gauge theory of basic interactions linked with internal symmetry and the spontaneous breaking of these symmetries, the Nobel prize winners have summarized the present situation and the immediate problems. At the end, an extrapolation of the future is also given

  11. Similarity-Based Unification: A Multi-Adjoint Approach

    Czech Academy of Sciences Publication Activity Database

    Medina, J.; Ojeda-Aciego, M.; Vojtáš, Peter

    2004-01-01

    Roč. 146, č. 1 (2004), s. 43-62 ISSN 0165-0114 Source of funding: V - iné verejné zdroje Keywords : similarity * fuzzy unification Subject RIV: BA - General Mathematics Impact factor: 0.734, year: 2004

  12. Gauge coupling unification in realistic free-fermionic string models

    International Nuclear Information System (INIS)

    Dienes, K.R.; Faraggi, A.E.

    1995-01-01

    We discuss the unification of gauge couplings within the framework of a wide class of realistic free-fermionic string models which have appeared in the literature, including the flipped SU(5), SO(6)xSO(4), and various SU(3)xSU(2)xU(1) models. If the matter spectrum below the string scale is that of the Minimal Supersymmetric Standard Model (MSSM), then string unification is in disagreement with experiment. We therefore examine several effects that may modify the minimal string predictions. First, we develop a systematic procedure for evaluating the one-loop heavy string threshold corrections in free-fermionic string models, and we explicitly evaluate these corrections for each of the realistic models. We find that these string threshold corrections are small, and we provide general arguments explaining why such threshold corrections are suppressed in string theory. Thus heavy thresholds cannot resolve the disagreement with experiment. We also study the effect of non-standard hypercharge normalizations, light SUSY thresholds, and intermediate-scale gauge structure, and similarly conclude that these effects cannot resolve the disagreement with low-energy data. Finally, we examine the effects of additional color triplets and electroweak doublets beyond the MSSM. Although not required in ordinary grand unification scenarios, such states generically appear within the context of certain realistic free-fermionic string models. We show that if these states exist at the appropriate thresholds, then the gauge couplings will indeed unify at the string scale. Thus, within these string models, string unification can be in agreement with low-energy data. (orig.)

  13. Gauge unification of basic forces particularly of gravitation with strong interactions

    International Nuclear Information System (INIS)

    Salam, A.

    1977-01-01

    Corresponding to the two known types of gauge theories, Yang-Mills with spin-one mediating particles and Einstein Weyl with spin-two mediating particles, it is speculated that two distinct gauge unifications of the basic forces appear to be taking place. One is the familiar Yang-Mills unification of weak and electromagnetic forces with the strong. The second is the less familiar gauge unification of gravitation with spin-two tensor-dominated aspects of strong interactions. It is proposed that there are strongly interacting spin-two strong gravitons obeying Einstein's equations, and their existence gives a clue to an understanding of the (partial) confinement of quarks, as well as of the concept of hadronic temperature, through the use of Schwarzschild de-Sitter-like partially confining solitonic solutions of the strong gravity Einstein equation

  14. Revising and editing for translators

    CERN Document Server

    Mossop, Brian

    2014-01-01

    Revising and Editing for Translators provides guidance and learning materials for translation students learning to edit texts written by others, and professional translators wishing to improve their self-revision ability or learning to revise the work of others. Editing is understood as making corrections and improvements to texts, with particular attention to tailoring them to the given readership. Revising is this same task applied to draft translations. The linguistic work of editors and revisers is related to the professional situations in which they work. Mossop offers in-depth coverage of a wide range of topics, including copyediting, style editing, structural editing, checking for consistency, revising procedures and principles, and translation quality assessment. This third edition provides extended coverage of computer aids for revisers, and of the different degrees of revision suited to different texts. The inclusion of suggested activities and exercises, numerous real-world examples, a proposed gra...

  15. Gauge coupling unification and nonequilibrium thermal dark matter.

    Science.gov (United States)

    Mambrini, Yann; Olive, Keith A; Quevillon, Jérémie; Zaldívar, Bryan

    2013-06-14

    We study a new mechanism for the production of dark matter in the Universe which does not rely on thermal equilibrium. Dark matter is populated from the thermal bath subsequent to inflationary reheating via a massive mediator whose mass is above the reheating scale T(RH). To this end, we consider models with an extra U(1) gauge symmetry broken at some intermediate scale (M(int) ≃ 10(10)-10(12) GeV). We show that not only does the model allow for gauge coupling unification (at a higher scale associated with grand unification) but it can provide a dark matter candidate which is a standard model singlet but charged under the extra U(1). The intermediate scale gauge boson(s) which are predicted in several E6/SO(10) constructions can be a natural mediator between dark matter and the thermal bath. We show that the dark matter abundance, while never having achieved thermal equilibrium, is fixed shortly after the reheating epoch by the relation T(RH)(3)/M(int)(4). As a consequence, we show that the unification of gauge couplings which determines M(int) also fixes the reheating temperature, which can be as high as T(RH) ≃ 10(11) GeV.

  16. Unification and new particles at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Arkani-Hamed, Nima; D’Agnolo, Raffaele Tito; Low, Matthew [School of Natural Sciences, Institute for Advanced Study,Einstein Drive, Princeton, NJ 08540 (United States); Pinner, David [Princeton Center for Theoretical Physics, Princeton University,Jadwin Hall, Princeton, NJ 08544 (United States)

    2016-11-14

    Precision gauge coupling unification is one of the primary quantitative successes of low energy or split supersymmetry. Preserving this success puts severe restrictions on possible matter and gauge sectors that might appear at collider-accessible energies. In this work we enumerate new gauge sectors which are compatible with unification, consisting of horizontal gauge groups acting on vector-like matter charged under the Standard Model. Interestingly, almost all of these theories are in the supersymmetric conformal window at high energies and confine quickly after the superpartners are decoupled. For a range of scalar masses compatible with both moderately tuned and minimally split supersymmetry, the confining dynamics happen at the multi-TeV scale, leading to a spectrum of multiple spin-0 and spin-1 resonances accessible to the LHC, with unusual quantum numbers and striking decay patterns.

  17. Unification and new particles at the LHC

    International Nuclear Information System (INIS)

    Arkani-Hamed, Nima; D’Agnolo, Raffaele Tito; Low, Matthew; Pinner, David

    2016-01-01

    Precision gauge coupling unification is one of the primary quantitative successes of low energy or split supersymmetry. Preserving this success puts severe restrictions on possible matter and gauge sectors that might appear at collider-accessible energies. In this work we enumerate new gauge sectors which are compatible with unification, consisting of horizontal gauge groups acting on vector-like matter charged under the Standard Model. Interestingly, almost all of these theories are in the supersymmetric conformal window at high energies and confine quickly after the superpartners are decoupled. For a range of scalar masses compatible with both moderately tuned and minimally split supersymmetry, the confining dynamics happen at the multi-TeV scale, leading to a spectrum of multiple spin-0 and spin-1 resonances accessible to the LHC, with unusual quantum numbers and striking decay patterns.

  18. Macroscopic constraints on string unification

    International Nuclear Information System (INIS)

    Taylor, T.R.

    1989-03-01

    The comparison of sting theory with experiment requires a huge extrapolation from the microscopic distances, of order of the Planck length, up to the macroscopic laboratory distances. The quantum effects give rise to large corrections to the macroscopic predictions of sting unification. I discus the model-independent constraints on the gravitational sector of string theory due to the inevitable existence of universal Fradkin-Tseytlin dilatons. 9 refs

  19. An electronic edition of eighteenth-century drama: the materiality of editing in performance

    Directory of Open Access Journals (Sweden)

    Pinto, Isabel

    2016-07-01

    Full Text Available In the domain of electronic edition, drama’s specificity has been considered in terms of metadata improvements and possibilities. At the same time, an increasing closeness between art history research and performance art has demonstrated its methodological value to assess the complex nature of the archive. My post-doctoral research follows the lead and goes as far as proposing that performance art can be an adequate methodology when preparing the electronic edition of eighteenth-century drama. Furthermore, “performing the archive” can help to fill the gap between the eventful nature of drama manuscripts and the audience of today, suggesting new ways of approaching the specific materiality of the plays.

  20. Dead links, vaporcuts, and creativity in fan edit replication

    Directory of Open Access Journals (Sweden)

    Joshua Wille

    2015-09-01

    Full Text Available In my examination of a Star Wars prequel trilogy fan edit reportedly made by Topher Grace, I introduce the term vaporcut to describe fan edits with reputations that may generate critical discourse but that are not publicly released. I explore the ways some fan editors attempt to recreate intangible projects but inevitably produce variant works that reflect their own creative perspectives.

  1. Edition des Corpus areopagiticum slavicum

    Directory of Open Access Journals (Sweden)

    Dieter Fahl

    2005-12-01

    Full Text Available An Edition of the Corpus areopagiticum slavicum In the fourteenth century, the monk Isaiah of the holy Mount Athos translated the writings of pseudo-Dionysius the Areopagite (c. end of the 5th century, core texts for Eastern and Western European theological and philosophical thought, from Greek into Church Slavonic. This first Slavic translation of Dionysius’ oeuvre (“De Coelesti Hierarchia,” “De Ecclesiastica Hierarchia,” “De Divinis Nominibus,” “De Mystica Theologia,” the epistles and scholia, which played a significant role in the development of Slavic culture, Orthodox Slavic socio-political theory and praxis, is still central to the study of Slavia Orthodoxa. A working group of German and Russian scholars has completed an edition of the translator’s Church Slavonic autograph with an en face reconstruction of the Greek text used by the translator and philological commentary. A Church Slavonic-Greek and Greek-Church Slavonic dictionary of this edition, currently in preparation, plans to make the terminology used in this influential translation accessible to interdisciplinary researchers. For the first time, the Church Slavonic lexica of this corpus, a substantial part of which was coined by the translator, will be registered in an index of words and forms.

  2. Hierarchy problem, gauge coupling unification at the Planck scale, and vacuum stability

    Directory of Open Access Journals (Sweden)

    Naoyuki Haba

    2015-11-01

    Full Text Available From the point of view of the gauge hierarchy problem, introducing an intermediate scale in addition to TeV scale and the Planck scale (MPl=2.4×1018 GeV is unfavorable. In that way, a gauge coupling unification (GCU is expected to be realized at MPl. We explore possibilities of GCU at MPl by adding a few extra particles with TeV scale mass into the standard model (SM. When extra particles are fermions and scalars (only fermions with the same mass, the GCU at MPl can (not be realized. On the other hand, when extra fermions have different masses, the GCU can be realized around 8πMPl without extra scalars. This simple SM extension has two advantages that a vacuum becomes stable up to MPl (8πMPl and a proton lifetime becomes much longer than an experimental bound.

  3. ELECTRONIC PROFESSIONAL EDITIONS IN THE SYSTEM OF SCIENTIFIC PERIODICALS: STATE AND PROSPECTS

    Directory of Open Access Journals (Sweden)

    Nataliia M. Kropocheva

    2014-02-01

    Full Text Available The article highlights relevant current problems concerning the formation, present state and prospects of the development of the native electronic professional editions on pedagogy. The historical overview of the development of the electronic books in the world and in Ukraine in general, and also including the professional editions was made. It was conducted the analysis of national and international legal framework for existing electronic editions, as well as researched the structure and software of the native electronic professional editions on pedagogy. Based on the results, it was formulated the conclusions and developed some suggestions for the improvement of electronic editions.

  4. Collaborative Work and Language Learners' Identities When Editing Academic Texts

    Science.gov (United States)

    Caviedes, Lorena; Meza, Angélica; Rodriguez, Ingrid

    2016-01-01

    This paper presents a qualitative case study that involved three groups of English as a foreign language pre-service teachers at a Colombian private university. Each group attended tutoring sessions during an academic semester. Along these sessions, students were asked to work collaboratively in the editing process of some chapters of their thesis…

  5. Challenges for automatically extracting molecular interactions from full-text articles.

    Science.gov (United States)

    McIntosh, Tara; Curran, James R

    2009-09-24

    The increasing availability of full-text biomedical articles will allow more biomedical knowledge to be extracted automatically with greater reliability. However, most Information Retrieval (IR) and Extraction (IE) tools currently process only abstracts. The lack of corpora has limited the development of tools that are capable of exploiting the knowledge in full-text articles. As a result, there has been little investigation into the advantages of full-text document structure, and the challenges developers will face in processing full-text articles. We manually annotated passages from full-text articles that describe interactions summarised in a Molecular Interaction Map (MIM). Our corpus tracks the process of identifying facts to form the MIM summaries and captures any factual dependencies that must be resolved to extract the fact completely. For example, a fact in the results section may require a synonym defined in the introduction. The passages are also annotated with negated and coreference expressions that must be resolved.We describe the guidelines for identifying relevant passages and possible dependencies. The corpus includes 2162 sentences from 78 full-text articles. Our corpus analysis demonstrates the necessity of full-text processing; identifies the article sections where interactions are most commonly stated; and quantifies the proportion of interaction statements requiring coherent dependencies. Further, it allows us to report on the relative importance of identifying synonyms and resolving negated expressions. We also experiment with an oracle sentence retrieval system using the corpus as a gold-standard evaluation set. We introduce the MIM corpus, a unique resource that maps interaction facts in a MIM to annotated passages within full-text articles. It is an invaluable case study providing guidance to developers of biomedical IR and IE systems, and can be used as a gold-standard evaluation set for full-text IR tasks.

  6. Testing the AGN Unification Model in the Infrared

    International Nuclear Information System (INIS)

    Ramos Almeida, C; Levenson, N A; Radomski, J T; Alonso-Herrero, A; Asensio Ramos, A; Rodríguez Espinosa, J M; Pérez García, A M; Packham, C; Mason, R; Díaz-Santos, T

    2012-01-01

    We present near-to-mid-infrared spectral energy distributions (SEDs) for 21 Seyfert galaxies, using subarcsecond resolution imaging data. Our aim is to compare the properties Seyfert 1 (Sy1) and Seyfert 2 (Sy2) tori using clumpy torus models and a Bayesian approach to fit the infrared (IR) nuclear SEDs. These dusty tori have physical sizes smaller than 6 pc radius, as derived from our fits. Active galactic nuclei (AGN) unification schemes account for a variety of observational differences in terms of viewing geometry. However, we find evidence that strong unification may not hold, and that the immediate dusty surroundings of Sy1 and Sy2 nuclei are intrinsically different. The Type 2 tori studied here are broader, have more clumps, and these clumps have lower optical depths than those of Type 1 tori. The larger the covering factor of the torus, the smaller the probability of having direct view of the AGN, and vice-versa. In our sample, Sy2 tori have larger covering factors (C T = 0.95±0.02) and smaller escape probabilities than those of Sy1 (C T = 0.5±0.1). Thus, on the basis of the results presented here, the classification of a Seyfert galaxy may depend more on the intrinsic properties of the torus rather than on its mere inclination, in contradiction with the simplest unification model.

  7. SO(14) unification of 3+1 families

    International Nuclear Information System (INIS)

    Karadayi, H.R.

    1982-03-01

    It is shown that the unification of 3+1 families is possible within the framework of 64 dimensional spinor representation of SO(14). Special care is given for a description without the heavy excess fermions such as conjugate and mirror or completely exotic fermions of some family unification schemes. With the aid of an intrinsic ''L-R Asymmetry'' mechanism which we proposed recently, the conventional strong and electromagnetic interactions are obtained for all four families by concentrating only on the symmetry breaking SO(14) → SU(3)sub(c) x U(1)sub(e.m.). However, the conventional weak interactions of the first three families are obtained just as in the standard SU(2)sub(L) x U(1)sub(Y) model, while those of the prescribed fourth family show certain differences. This is what we mean by 3+1 family unification. All vector particles mediating strong, electromagnetic and weak interactions which are the subjects of present phenomenological tests are specified among the vector fields of SO(14) and their mass mechanisms leading to a consistent description of this low-energy phenomenology are studied with the aid of the Higgs multiplets 14, 364, 1716 and 2002 of SO(14). Moreover, the fermion mass mechanisms are considered with the aid of these scalar multiplets and the contributions from these scalars to the vector and fermion masses are explicitly calculated. All these calculations are carried out in the new mathematical technique for the Lie algebra representations which we introduced recently. (author)

  8. Classification of protein-protein interaction full-text documents using text and citation network features.

    Science.gov (United States)

    Kolchinsky, Artemy; Abi-Haidar, Alaa; Kaur, Jasleen; Hamed, Ahmed Abdeen; Rocha, Luis M

    2010-01-01

    We participated (as Team 9) in the Article Classification Task of the Biocreative II.5 Challenge: binary classification of full-text documents relevant for protein-protein interaction. We used two distinct classifiers for the online and offline challenges: 1) the lightweight Variable Trigonometric Threshold (VTT) linear classifier we successfully introduced in BioCreative 2 for binary classification of abstracts and 2) a novel Naive Bayes classifier using features from the citation network of the relevant literature. We supplemented the supplied training data with full-text documents from the MIPS database. The lightweight VTT classifier was very competitive in this new full-text scenario: it was a top-performing submission in this task, taking into account the rank product of the Area Under the interpolated precision and recall Curve, Accuracy, Balanced F-Score, and Matthew's Correlation Coefficient performance measures. The novel citation network classifier for the biomedical text mining domain, while not a top performing classifier in the challenge, performed above the central tendency of all submissions, and therefore indicates a promising new avenue to investigate further in bibliome informatics.

  9. MeSH: a window into full text for document summarization.

    Science.gov (United States)

    Bhattacharya, Sanmitra; Ha-Thuc, Viet; Srinivasan, Padmini

    2011-07-01

    Previous research in the biomedical text-mining domain has historically been limited to titles, abstracts and metadata available in MEDLINE records. Recent research initiatives such as TREC Genomics and BioCreAtIvE strongly point to the merits of moving beyond abstracts and into the realm of full texts. Full texts are, however, more expensive to process not only in terms of resources needed but also in terms of accuracy. Since full texts contain embellishments that elaborate, contextualize, contrast, supplement, etc., there is greater risk for false positives. Motivated by this, we explore an approach that offers a compromise between the extremes of abstracts and full texts. Specifically, we create reduced versions of full text documents that contain only important portions. In the long-term, our goal is to explore the use of such summaries for functions such as document retrieval and information extraction. Here, we focus on designing summarization strategies. In particular, we explore the use of MeSH terms, manually assigned to documents by trained annotators, as clues to select important text segments from the full text documents. Our experiments confirm the ability of our approach to pick the important text portions. Using the ROUGE measures for evaluation, we were able to achieve maximum ROUGE-1, ROUGE-2 and ROUGE-SU4 F-scores of 0.4150, 0.1435 and 0.1782, respectively, for our MeSH term-based method versus the maximum baseline scores of 0.3815, 0.1353 and 0.1428, respectively. Using a MeSH profile-based strategy, we were able to achieve maximum ROUGE F-scores of 0.4320, 0.1497 and 0.1887, respectively. Human evaluation of the baselines and our proposed strategies further corroborates the ability of our method to select important sentences from the full texts. sanmitra-bhattacharya@uiowa.edu; padmini-srinivasan@uiowa.edu.

  10. Full Text Psychology Journals Available from Popular Library Databases

    Science.gov (United States)

    Joswick, Kathleen E.

    2006-01-01

    The author identified 433 core journals in psychology and investigated their full text availability in popular databases. While 62 percent of the studied journals were available in at least one database, access from individual databases ranged from 1.4 percent to 38.1 percent of the titles. The full text of influential psychology journals is not…

  11. Deletions in cox2 mRNA result in loss of splicing and RNA editing and gain of novel RNA editing sites.

    Directory of Open Access Journals (Sweden)

    Stefanie Grüttner

    Full Text Available As previously demonstrated, the maize cox2 RNA is fully edited in cauliflower mitochondria. Use of constructs with a deleted cox2 intron, however, led to a loss of RNA editing at almost all editing sites, with only a few sites still partially edited. Likewise, one deletion in exon 1 and three in exon 2 abolish RNA editing at all cox2 sites analyzed. Furthermore, intron splicing is abolished using these deletions. Mutation of a cytosine residue, which is normally edited and localized directly adjacent to the intron, to thymidine did not result in restoration of splicing, indicating that the loss of splicing was not due to loss of RNA editing. One deletion in exon 2 did not lead to loss of splicing. Instead, most editing sites were found to be edited, only three were not edited. Unexpectedly, we observed additional RNA editing events at new sites. Thus it appears that deletions in the cox2 RNA sequence can have a strong effect on RNA processing, leading to loss of splicing, loss of editing at all sites, or even to a gain of new editing sites. As these effects are not limited to the vicinity of the respective deletions, but appear to be widespread or even affect all editing sites, they may not be explained by the loss of PPR binding sites. Instead, it appears that several parts of the cox2 transcript are required for proper RNA processing. This indicates the roles of the RNA sequence and structural elements in the recognition of the editing sites.

  12. Flavour Democracy in Strong Unification

    CERN Document Server

    Abel, S A; Abel, Steven; King, Steven

    1998-01-01

    We show that the fermion mass spectrum may naturally be understood in terms of flavour democratic fixed points in supersymmetric theories which have a large domain of attraction in the presence of "strong unification". Our approach provides an alternative to the approximate Yukawa texture zeroes of the Froggatt-Nielsen mechanism. We discuss a particular model based on a broken gauged $SU(3)_L\\times SU(3)_R$ family symmetry which illustrates our approach.

  13. Explanatory Unification by Proofs in School Mathematics

    Science.gov (United States)

    Komatsu, Kotaro; Fujita, Taro; Jones, Keith; Naoki, Sue

    2018-01-01

    Kitcher's idea of 'explanatory unification', while originally proposed in the philosophy of science, may also be relevant to mathematics education, as a way of enhancing student thinking and achieving classroom activity that is closer to authentic mathematical practice. There is, however, no mathematics education research treating explanatory…

  14. Electroweak unification and tree unitarity

    International Nuclear Information System (INIS)

    Horejsi, J.

    1993-01-01

    The monograph is an unconventional introduction into the theory of unification of weak and electromagnetic interactions, which is conceptually different from the exposition presented in standard textbooks. A detailed explanation is given of the way to the standard model of electroweak interactions which is based on a straightforward application of the requirement of renormalizability of the perturbation series expansion. The procedure to derive the model is interesting as it demonstrates the necessity of introducing vector bosons and Yang-Mills type interactions and at least one elementary scalar boson to obtain a renormalizable theory of weak and electromagnetic interactions. The book is divided into 5 chapters: introduction, problems encountered in a Fermi type theory, the intermediate vector boson, electrodynamics of vector bosons, tree unitarity, and electroweak interactions. Each chapter is completed with exercise problems to be solved by the reader. The text is supplemented with a number of appendices. The monograph is aimed at undergraduate and postgraduate students as well as at physicists interested in the theory of elementary particles. (Z.J.)

  15. Towards a critical edition of Fibonacci’s Liber Abaci

    Directory of Open Access Journals (Sweden)

    Giuseppe Germano

    2013-11-01

    Full Text Available A group of research working at the University of Naples Federico II aim to achieve the goal to offer a modern scientific and widely accessible edition of Fibonacci’s treatise. With a linguistic-philological, an historical-mathematical and a computer approach it has pointed out the value and the need for a multidisciplinary research in order to achieve the goal of making this edition adequately available to the scientific community.

  16. Editing Audio with Audacity

    Directory of Open Access Journals (Sweden)

    Brandon Walsh

    2016-08-01

    Full Text Available For those interested in audio, basic sound editing skills go a long way. Being able to handle and manipulate the materials can help you take control of your object of study: you can zoom in and extract particular moments to analyze, process the audio, and upload the materials to a server to compliment a blog post on the topic. On a more practical level, these skills could also allow you to record and package recordings of yourself or others for distribution. That guest lecture taking place in your department? Record it and edit it yourself! Doing so is a lightweight way to distribute resources among various institutions, and it also helps make the materials more accessible for readers and listeners with a wide variety of learning needs. In this lesson you will learn how to use Audacity to load, record, edit, mix, and export audio files. Sound editing platforms are often expensive and offer extensive capabilities that can be overwhelming to the first-time user, but Audacity is a free and open source alternative that offers powerful capabilities for sound editing with a low barrier for entry. For this lesson we will work with two audio files: a recording of Bach’s Goldberg Variations available from MusOpen and another recording of your own voice that will be made in the course of the lesson. This tutorial uses Audacity 2.1.2, released January 2016.

  17. Families in the nonperturbative unification scheme

    Energy Technology Data Exchange (ETDEWEB)

    Kapetanakis, D. (National Research Centre for the Physical Sciences Democritos, Athens (Greece)); Theisen, S. (European Organization for Nuclear Research, Geneva (Switzerland)); Zoupanos, G. (Ethnikon Metsovion Polytechneion, Athens (Greece). Dept. of Physics)

    1989-10-12

    Within the nonperturbative unification framework of Maiani, Parisi and Petronzio, we examine the influence of the number of fermion and Higgs families, when they are grouped in representations of horizontal family groups, on the low energy couplings of the standard model. In this way we find a number of new phenomenologically acceptable solutions for the standard model's low energy couplings. (orig.).

  18. Families in the nonperturbative unification scheme

    International Nuclear Information System (INIS)

    Kapetanakis, D.; Theisen, S.; Zoupanos, G.

    1989-01-01

    Within the nonperturbative unification framework of Maiani, Parisi and Petronzio, we examine the influence of the number of fermion and Higgs families, when they are grouped in representations of horizontal family groups, on the low energy couplings of the standard model. In this way we find a number of new phenomenologically acceptable solutions for the standard model's low energy couplings. (orig.)

  19. "Free full text articles": where to search for them?

    Science.gov (United States)

    Singh, Ashish; Singh, Manish; Singh, Ajai Kumar; Singh, Deepti; Singh, Pratibha; Sharma, Abhishek

    2011-07-01

    References form the backbone of any medical literature. Presently, because of high inflation, it is very difficult for any library/organization/college to purchase all journals. The condition is even worse for an individual person, such as private practitioners. The solution lies in the free availability of full-text articles. Here, the authors share their experiences about the accessibility of free full-text articles.

  20. Vector-like quarks and leptons, SU(5) ⊗ SU(5) grand unification, and proton decay

    International Nuclear Information System (INIS)

    Lee, Chang-Hun; Mohapatra, Rabindra N.

    2017-01-01

    SU(5) ⊗ SU(5) provides a minimal grand unification scheme for fermions and gauge forces if there are vector-like quarks and leptons in nature. We explore the gauge coupling unification in a non-supersymmetric model of this type, and study its implications for proton decay. The properties of vector-like quarks and intermediate scales that emerge from coupling unification play a central role in suppressing proton decay. We find that in this model, the familiar decay mode p→e + π 0 may have a partial lifetime within the reach of currently planned experiments.

  1. Authenticity and Unification in Quechua Language Planning.

    Science.gov (United States)

    Hornberger, Nancy H.; King, Kendall

    1998-01-01

    Examines the potentially problematic tension between the goals of authenticity and unification in Quechua-language planning. One case study examines the orthographic debate that arose in Peru, and the second case study concerns two indigenous communities in Saraguro in the Southern Ecuadorian highlands where Spanish predominates but two Quichua…

  2. Genetic Determinants of RNA Editing Levels of ADAR Targets in Drosophila melanogaster

    Directory of Open Access Journals (Sweden)

    Yerbol Z. Kurmangaliyev

    2016-02-01

    Full Text Available RNA editing usually affects only a fraction of expressed transcripts and there is a vast amount of variation in editing levels of ADAR (adenosine deaminase, RNA-specific targets. Here we explore natural genetic variation affecting editing levels of particular sites in 81 natural strains of Drosophila melanogaster. The analysis of associations between editing levels and single-nucleotide polymorphisms allows us to map putative cis-regulatory regions affecting editing of 16 A-to-I editing sites (cis-RNA editing quantitative trait loci or cis-edQTLs, P < 10−8. The observed changes in editing levels are validated by independent molecular technique. All identified regulatory variants are located in close proximity of modulated editing sites. Moreover, colocalized editing sites are often regulated by same loci. Similar to expression and splicing QTL studies, the characterization of edQTLs will greatly expand our understanding of cis-regulatory evolution of gene expression.

  3. Validation of the fifth edition BI-RADS ultrasound lexicon with comparison of fourth and fifth edition diagnostic performance using video clips

    Directory of Open Access Journals (Sweden)

    Jung Hyun Yoon

    2016-10-01

    Full Text Available Purpose The aim of this study was to evaluate the positive predictive value (PPV and the diagnostic performance of the ultrasonographic descriptors in the fifth edition of BI-RADS, comparing with the fourth edition using video clips. Methods From September 2013 to July 2014, 80 breast masses in 74 women (mean age, 47.5±10.7 years from five institutions of the Korean Society of Breast Imaging were included. Two radiologists individually reviewed the static and video images and analyzed the images according to the fourth and fifth edition of BI-RADS. The PPV of each descriptor was calculated and diagnostic performances between the fourth and fifth editions were compared. Results Of the 80 breast masses, 51 (63.8% were benign and 29 (36.2% were malignant. Suspicious ultrasonographic features such as irregular shape, non-parallel orientation, angular or spiculated margins, and combined posterior features showed higher PPV in both editions (all P0.05. The area under the receiver operating characteristics curve was higher in the fourth edition (0.708 to 0.690, without significance (P=0.416. Conclusion The fifth edition of the BI-RADS ultrasound lexicon showed comparable performance to the fourth edition and can be useful in the differential diagnosis of breast masses using ultrasonography.

  4. Grand unification in higher dimensions with split supersymmetry

    International Nuclear Information System (INIS)

    Schuster, Philip C.

    2006-01-01

    We investigate gauge coupling unification in higher dimensional GUT models with split supersymmetry. We focus on 5d and 6d orbifold GUTs, which permit a simple solution to several problems of 4D GUTs as well as control over GUT scale threshold corrections. In orbifold GUTs, calculable threshold corrections can raise or lower the prediction for α s (M Z ) in a way that depends on the location of Higgs fields. On the other hand, split supersymmetry lowers the prediction for α s (M Z ). Consequently, split supersymmetry changes the preferred location of the Higgs fields in orbifold GUTs. In the simplest models, we find that gauge coupling unification favors higgs doublets that live on the orbifold fixed points instead of in the bulk. In addition, relatively high scales of supersymmetry breaking of 10 10±2 GeV are generically favored

  5. Genome Editing in Sugarcane: Challenges ahead

    Directory of Open Access Journals (Sweden)

    Chakravarthi Mohan

    2016-10-01

    Full Text Available Genome editing opens new and unique opportunities for researchers to enhance crop production. Until 2013, the zinc finger nucleases (ZFNs and transcription activator-like effector nucleases (TALENs were the key tools used for genome editing applications. The advent of RNA-guided engineered nucleases - the type II clustered regularly interspaced short palindromic repeat (CRISPR/Cas9 (CRISPR-associated system from Streptococcus pyogenes holds great potential since it is simple, effective and more versatile than ZFNs and TALENs. CRISPR/Cas9 system has already been successfully employed in several crop plants. Use of these techniques is in its infant stage in sugarcane. Jung and Altpeter (2016 have reported TALEN mediated approach for the first time to reduce lignin content in sugarcane to make it amenable for biofuel production. This is so far the only report describing genome editing in sugarcane. Large genome size, polyploidy, low transformation efficiency, transgene silencing and lack of high throughput screening techniques are certainly great challenges for genome editing in sugarcane which would be discussed in detail in this review.

  6. The film’s the thing: film translation and its effect on a silent, edited and full text Hamlet The film’s the thing: film translation and its effect on a silent, edited and full text Hamlet

    Directory of Open Access Journals (Sweden)

    Janete R. Costa

    2008-04-01

    Full Text Available Translation is, at its best, a difficult path to tred, especially in a global, multicultural society. A word that defines an object may be in need of careful consideration and modification, not only to convey its individual meaning, but also to place it in the concept or intent when linked with others words forming a thought. The process is particularly complex when pairing a word with an image as is done in film. In the 1960’s, the American television classic, Star Trek, added new words as well as additional meaning to old words in the English lexicon. The definition of these words was clearly given in visual images that can still be recalled today. A typical exchange of dialogue may read: Captain, according to my tricorder, there is no intelligent life on this planet. Beam him up, Scotty. Energise. Translation is, at its best, a difficult path to tred, especially in a global, multicultural society. A word that defines an object may be in need of careful consideration and modification, not only to convey its individual meaning, but also to place it in the concept or intent when linked with others words forming a thought. The process is particularly complex when pairing a word with an image as is done in film. In the 1960’s, the American television classic, Star Trek, added new words as well as additional meaning to old words in the English lexicon. The definition of these words was clearly given in visual images that can still be recalled today. A typical exchange of dialogue may read: Captain, according to my tricorder, there is no intelligent life on this planet. Beam him up, Scotty. Energise.

  7. System description: Isabelle/jEdit in 2014

    Directory of Open Access Journals (Sweden)

    Makarius Wenzel

    2014-10-01

    Full Text Available This is an updated system description for Isabelle/jEdit, according to the official release Isabelle2014 (August 2014. The following new PIDE concepts are explained: asynchronous print functions and document overlays, syntactic and semantic completion, editor navigation, management of auxiliary files within the document-model.

  8. Towards a new paradigm for quark-lepton unification

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Christopher [Laboratoire de Physique Subatomique et de Cosmologie, Université Grenoble-Alpes, CNRS/IN2P3,53 avenue des Martyrs, 38026 Grenoble Cedex (France)

    2017-05-03

    The quark and charged lepton mass patterns upset their naïve unification. In this paper, a new approach to solve this problem is proposed. Model-independently, we find that a successful unification can be achieved. A mechanism is identified by which the large top quark mass renders its third-generation leptonic partner very light. This state is thus identified with the electron. We then construct a toy model to implement dynamically this mechanism, using tree-level exchanges of vector leptons to relate the quark and charged lepton flavor structures. In a supersymmetric context, this same mechanism splits the squark masses, and third generation squarks end up much lighter than the others. Finally, the implementation of this mechanism in SU(5) GUT permits to avoid introducing any flavor structure beyond the two minimal Yukawa couplings, ensuring the absence of unknown mixing matrices and their potentially large impact on FCNC.

  9. Full text and figure display improves bioscience literature search.

    Directory of Open Access Journals (Sweden)

    Anna Divoli

    Full Text Available When reading bioscience journal articles, many researchers focus attention on the figures and their captions. This observation led to the development of the BioText literature search engine, a freely available Web-based application that allows biologists to search over the contents of Open Access Journals, and see figures from the articles displayed directly in the search results. This article presents a qualitative assessment of this system in the form of a usability study with 20 biologist participants using and commenting on the system. 19 out of 20 participants expressed a desire to use a bioscience literature search engine that displays articles' figures alongside the full text search results. 15 out of 20 participants said they would use a caption search and figure display interface either frequently or sometimes, while 4 said rarely and 1 said undecided. 10 out of 20 participants said they would use a tool for searching the text of tables and their captions either frequently or sometimes, while 7 said they would use it rarely if at all, 2 said they would never use it, and 1 was undecided. This study found evidence, supporting results of an earlier study, that bioscience literature search systems such as PubMed should show figures from articles alongside search results. It also found evidence that full text and captions should be searched along with the article title, metadata, and abstract. Finally, for a subset of users and information needs, allowing for explicit search within captions for figures and tables is a useful function, but it is not entirely clear how to cleanly integrate this within a more general literature search interface. Such a facility supports Open Access publishing efforts, as it requires access to full text of documents and the lifting of restrictions in order to show figures in the search interface.

  10. Genome Editing Redefines Precision Medicine in the Cardiovascular Field

    Directory of Open Access Journals (Sweden)

    Elda Dzilic

    2018-01-01

    Full Text Available Genome editing is a powerful tool to study the function of specific genes and proteins important for development or disease. Recent technologies, especially CRISPR/Cas9 which is characterized by convenient handling and high precision, revolutionized the field of genome editing. Such tools have enormous potential for basic science as well as for regenerative medicine. Nevertheless, there are still several hurdles that have to be overcome, but patient-tailored therapies, termed precision medicine, seem to be within reach. In this review, we focus on the achievements and limitations of genome editing in the cardiovascular field. We explore different areas of cardiac research and highlight the most important developments: (1 the potential of genome editing in human pluripotent stem cells in basic research for disease modelling, drug screening, or reprogramming approaches and (2 the potential and remaining challenges of genome editing for regenerative therapies. Finally, we discuss social and ethical implications of these new technologies.

  11. Gauge unification in highly anisotropic string compactifications

    International Nuclear Information System (INIS)

    Hebecker, A.; Trapletti, M.

    2005-01-01

    It is well known that heterotic string compactifications have, in spite of their conceptual simplicity and aesthetic appeal, a serious problem with precision gauge coupling unification in the perturbative regime of string theory. Using both a duality-based and a field-theoretic definition of the boundary of the perturbative regime, we reevaluate the situation in a quantitative manner. We conclude that the simplest and most promising situations are those where some of the compactification radii are exceptionally large, corresponding to highly anisotropic orbifold models. Thus, one is led to consider constructions which are known to the effective field-theorist as higher-dimensional or orbifold grand unified theories (orbifold GUTs). In particular, if the discrete symmetry used to break the GUT group acts freely, a non-local breaking in the larger compact dimensions can be realized, leading to a precise gauge coupling unification as expected on the basis of the MSSM particle spectrum. Furthermore, a somewhat more model dependent but nevertheless very promising scenario arises if the GUT breaking is restricted to certain singular points within the manifold spanned by the larger compactification radii

  12. The Third Edition of the Inka Brodzka-Wald Award

    Directory of Open Access Journals (Sweden)

    Jolanta Sujecka

    2016-12-01

    Full Text Available The Third Edition of the Inka Brodzka-Wald Award On 16 June 2015, the Academy for the Development of Philanthropy in Poland and the Adam Mickiewicz Literary Society announced the winners of the third edition of the Inka Brodzka-Wald Award for doctoral dissertations in the humanities. The competition was open for theses which concerned present issues and were defended in 2014.   Komunikat o rozstrzygnięciu trzeciej edycji Nagrody im. Inki Brodzkiej-Wald za rok 2014.

  13. Principles of the Unification of Our Agency

    Science.gov (United States)

    Roth, Klas

    2011-01-01

    Do we need principles of the unification of our agency, our mode of acting? Immanuel Kant and Christine Korsgaard argue that the reflective structure of our mind forces us to have some conception of ourselves, others and the world--including our agency--and that it is through will and reason, and in particular principles of our agency, that we…

  14. L’Autriche face à la réunification allemande

    Directory of Open Access Journals (Sweden)

    Gérard Grelle

    2012-11-01

    Full Text Available La chute du Mur de Berlin, en 1989, fut certes pour l’Autriche un événement politique majeur, mais pas plus important que la fin du rideau de fer. En effet, quasiment « enclavée » entre plusieurs pays socialistes, l’Autriche considéra la disparition du rideau de fer comme une ouverture sans limite aux pays d’Europe Centrale et de l’Est. Au cours des vingt années qui suivirent ces événements, l’Autriche a largement contribué au développement politique, économique et social des pays de l’Est en pratiquant une politique d’échanges économiques et financiers avec ces pays afin d’aider à leur reconstruction. Dans un tel contexte, la chute du Mur de Berlin et la réunification allemande ont été appréhendées comme un simple élément du puzzle de la reconstruction européenne. Une telle stratégie a alors permis à l’Autriche de sortir définitivement de son inquiétude face à la persistance d’un danger « annexionniste » de la part de l’Allemagne.

  15. Database citation in full text biomedical articles.

    Science.gov (United States)

    Kafkas, Şenay; Kim, Jee-Hyub; McEntyre, Johanna R

    2013-01-01

    Molecular biology and literature databases represent essential infrastructure for life science research. Effective integration of these data resources requires that there are structured cross-references at the level of individual articles and biological records. Here, we describe the current patterns of how database entries are cited in research articles, based on analysis of the full text Open Access articles available from Europe PMC. Focusing on citation of entries in the European Nucleotide Archive (ENA), UniProt and Protein Data Bank, Europe (PDBe), we demonstrate that text mining doubles the number of structured annotations of database record citations supplied in journal articles by publishers. Many thousands of new literature-database relationships are found by text mining, since these relationships are also not present in the set of articles cited by database records. We recommend that structured annotation of database records in articles is extended to other databases, such as ArrayExpress and Pfam, entries from which are also cited widely in the literature. The very high precision and high-throughput of this text-mining pipeline makes this activity possible both accurately and at low cost, which will allow the development of new integrated data services.

  16. Reconciling grand unification with strings by anisotropic compactifications

    International Nuclear Information System (INIS)

    Dundee, Ben; Raby, Stuart; Wingerter, Akin

    2008-01-01

    We analyze gauge coupling unification in the context of heterotic strings on anisotropic orbifolds. This construction is very much analogous to effective five-dimensional orbifold grand unified theory field theories. Our analysis assumes three fundamental scales: the string scale M S , a compactification scale M C , and a mass scale for some of the vectorlike exotics M EX ; the other exotics are assumed to get mass at M S . In the particular models analyzed, we show that gauge coupling unification is not possible with M EX =M C , and in fact we require M EX C ∼3x10 16 GeV. We find that about 10% of the parameter space has a proton lifetime (from dimension six gauge exchange) 10 33 yr 0 e + ) 36 yr. The other 80% of the parameter space gives proton lifetimes below Super-Kamiokande bounds. The next generation of proton decay experiments should be sensitive to the remaining parameter space.

  17. Natural supersymmetry and unification in five dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Abdalgabar, Ammar [National Institute for Theoretical Physics and School of Physics and Mandelstam Institute for Theoretical Physics, University of the Witwatersrand,Private Bag 3, Wits, 2050 (South Africa); Department of Physics, Sudan University of Science and Technology,Khartoum, 407 (Sudan); Cornell, Alan S. [National Institute for Theoretical Physics and School of Physics and Mandelstam Institute for Theoretical Physics, University of the Witwatersrand,Private Bag 3, Wits, 2050 (South Africa); Deandrea, Aldo [Université de Lyon,92, rue Pasteur, Lyon, F-69361 (France); IPNL, Université Lyon 1, CNRS/IN2P3,4 rue Fermi, Villeurbanne Cedex, F-69622 (France); Institut Universitaire de France,103 boulevard Saint-Michel, Paris, 75005 (France); McGarrie, Moritz [Faculty of Physics, University of Warsaw,Hoża 69, Warsaw, 00-681 (Poland)

    2016-01-14

    We explore unification and natural supersymmetry in a five dimensional extension of the standard model in which the extra dimension may be large, of the order of 1–10 TeV. Power law running generates a TeV scale A{sub t} term allowing for the observed 125 GeV Higgs and allowing for stop masses below 2 TeV, compatible with a natural SUSY spectrum. We supply the full one-loop RGEs for various models and use metastability to give a prediction that the gluino mass should be lighter than 3.5 TeV for A{sub t}≥−2.5 TeV, for such a compactification scale, with brane localised 3rd generation matter. We also discuss models in which only the 1st and 2nd generation of matter fields are located in the bulk. We also look at electroweak symmetry breaking in these models.

  18. Radio Loud AGN Unification: Connecting Jets and Accretion

    Directory of Open Access Journals (Sweden)

    Meyer Eileen T.

    2013-12-01

    Full Text Available While only a fraction of Active Galactic Nuclei are observed to host a powerful relativistic jet, a cohesive picture is emerging that radio-loud AGN may represent an important phase in the evolution of galaxies and the growth of the central super-massive black hole. I will review my own recent observational work in radio-loud AGN unification in the context of understanding how and why jets form and their the connection to different kinds of accretion and growing the black hole, along with a brief discussion of possible connections to recent modeling work in jet formation. Starting from the significant observational advances in our understanding of jetted AGN as a population over the last decade thanks to new, more sensitive instruments such as Fermi and Swift as well as all-sky surveys at all frequencies, I will lay out the case for a dichotomy in the jetted AGN population connected to accretion mode onto the black hole. In recent work, we have identified two sub-populations of radio-loud AGN which appear to be distinguished by jet structure, where low-efficiency accreting systems produce ‘weak’ jets which decelerate more rapidly than the ’strong’ jets of black holes accreting near the Eddington limit. The two classes are comprised of: (1The weak jet sources, corresponding to the less collimated, edge-darkened FR Is, with a decelerating or spine-sheath jet with velocity gradients, and (2 The strong jet sources, having fast, collimated jets, and typically displaying strong emission lines. The dichotomy in the vp-Lp plane can be understood as a "broken power sequence" in which jets exist on one branch or the other based on the particular accretion mode (Georganopolous 2011.We suggest that the intrinsic kinetic power (as measured by low-frequency, isotropic radio emission, the orientation, and the accretion rate of the SMBH system are the the fundamental axes needed for unification of radio-loud AGN by studying a well-characterized sample

  19. Deductive Synthesis of the Unification Algorithm,

    Science.gov (United States)

    1981-06-01

    DEDUCTIVE SYNTHESIS OF THE I - UNIFICATION ALGORITHM Zohar Manna Richard Waldinger I F? Computer Science Department Artificial Intelligence Center...theorem proving," Artificial Intelligence Journal, Vol. 9, No. 1, pp. 1-35. Boyer, R. S. and J S. Moore [Jan. 19751, "Proving theorems about LISP...d’Intelligence Artificielle , U.E.R. de Luminy, Universit6 d’ Aix-Marseille II. Green, C. C. [May 1969], "Application of theorem proving to problem

  20. Searching for Bill and Jane: Electronic Full-Text Literature.

    Science.gov (United States)

    Still, Julie; Kassabian, Vibiana

    1998-01-01

    Examines electronic full-text literature available on the World Wide Web and on CD-ROM. Discusses authors and genres, electronic texts, and fees. Highlights Shakespeare, Jane Austen, and nature writing. Provides a bibliography of Web guides, specialized Shakespeare pages, and pages dealing with the Shakespeare authorship debate and secondary…

  1. Gauge coupling unification from unified theories in higher dimensions

    International Nuclear Information System (INIS)

    Hall, Lawrence J.; Nomura, Yasunori

    2002-01-01

    Higher dimensional grand unified theories, with gauge symmetry breaking by orbifold compactification, possess SU(5) breaking at fixed points, and do not automatically lead to tree-level gauge coupling unification. A new framework is introduced that guarantees precise unification--even the leading loop threshold corrections are predicted, although they are model dependent. Precise agreement with the experimental result, α s exp =0.117±0.002, occurs only for a unique theory, and gives α s KK =0.118±0.004±0.003. Remarkably, this unique theory is also the simplest, with SU(5) gauge interactions and two Higgs hypermultiplets propagating in a single extra dimension. This result is more successful and precise than that obtained from conventional supersymmetric grand unification, α s SGUT =0.130±0.004±Δ SGUT . There is a simultaneous solution to the three outstanding problems of 4D supersymmetric grand unified theories: a large mass splitting between Higgs doublets and their color triplet partners is forced, proton decay via dimension five operators is automatically forbidden, and the absence of fermion mass relations amongst light quarks and leptons is guaranteed, while preserving the successful m b /m τ relation. The theory necessarily has a strongly coupled top quark located on a fixed point and part of the lightest generation propagating in the bulk. The string and compactification scales are determined to be around 10 17 GeV and 10 15 GeV, respectively

  2. Invariant practical tasks for work with text documents at the secondary school

    Directory of Open Access Journals (Sweden)

    Л И Карташова

    2013-12-01

    Full Text Available In article examples of practical tasks on creation, editing and formatting of text documents focused on pupils of the secondary school are given. Tasks have invariant character and don't depend on concrete software.

  3. Unification of Forces: The Road to Jointness?

    Science.gov (United States)

    1991-05-15

    tend to resist large change--or innovation. Because organizations value "predictability, stability, and certainty," incremental change is the...preferred mode of behavior for organizations.29 Unification of the forces would be a large, rather than an incremental , change; thus, the services would...coordinating planning and bidgeting , providing unified direction, accounting and controlling weapons and equipment acquisition, eliminating duplication of

  4. Quantum gravity unification via transfinite arithmetic and geometrical averaging

    International Nuclear Information System (INIS)

    El Naschie, M.S.

    2008-01-01

    In E-Infinity theory, we have not only infinitely many dimensions but also infinitely many fundamental forces. However, due to the hierarchical structure of ε (∞) spacetime we have a finite expectation number for its dimensionality and likewise a finite expectation number for the corresponding interactions. Starting from the preceding fundamental principles and using the experimental findings as well as the theoretical value of the coupling constants of the electroweak and the strong forces we present an extremely simple averaging procedure for determining the quantum gravity unification coupling constant with and without super symmetry. The work draws heavily on previous results, in particular a paper, by the Slovian Prof. Marek-Crnjac [Marek-Crnjac L. On the unification of all fundamental forces in a fundamentally fuzzy Cantorian ε (∞) manifold and high energy physics. Chaos, Solitons and Fractals 2004;4:657-68

  5. Dark matter, mirror world, and E6 unification

    International Nuclear Information System (INIS)

    Das, Ch. R.; Laperashvili, L. V.

    2009-01-01

    The idea that the ordinary (O) and mirror (M) worlds exist simultaneously is developed. It is shown that, in the case of a violated mirror parity (MP), the renormalization-group evolution of the coupling constants, which is represented in the O world by the dependence α i -1 (μ) (μ is an energy variable), is not identical to the evolution of the coupling constants α' i -1 (μ) in the M world. Here, the index i labels the symmetry group under consideration, while a dash labels quantities defined in the M world. It is assumed that E 6 unification predicted by superstring theory restores MP at the unification scale M SGUT ∼ 10 18 GeV, this inevitably leading to the difference in the violation of E 6 unification in the O and M worlds at lower energies: E 6 → SO(10) x U(1) Z and E' 6 → SU(6)' x SU(2)' Z . Considering only asymptotically free theories, we present the evolution of all the inverse coupling constants α i -1 (μ) in the one-loop approximation. In dealing with the M world involving MP violation, we then arrive at the model of the accelerating expansion of our Universe, where the axion ('acceleron') belongs to the SU(2)' Z group of the M world. The coupling constant g' Z , which grows indefinitely at the scale Λ' Z ∼ 10 -3 eV, is associated with this group. Within this theory, our Universe is in the false vacuum of the M world, in agreement with the phenomenologically observed cosmological constant of about (3 x 10 -3 eV) 4 .

  6. FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling

    Directory of Open Access Journals (Sweden)

    Jonathan Arias-Fuenzalida

    2017-11-01

    Full Text Available Genome editing and human induced pluripotent stem cells hold great promise for the development of isogenic disease models and the correction of disease-associated mutations for isogenic tissue therapy. CRISPR-Cas9 has emerged as a versatile and simple tool for engineering human cells for such purposes. However, the current protocols to derive genome-edited lines require the screening of a great number of clones to obtain one free of random integration or on-locus non-homologous end joining (NHEJ-containing alleles. Here, we describe an efficient method to derive biallelic genome-edited populations by the use of fluorescent markers. We call this technique FACS-assisted CRISPR-Cas9 editing (FACE. FACE allows the derivation of correctly edited polyclones carrying a positive selection fluorescent module and the exclusion of non-edited, random integrations and on-target allele NHEJ-containing cells. We derived a set of isogenic lines containing Parkinson's-disease-associated mutations in α-synuclein and present their comparative phenotypes.

  7. Study of theory and phenomenology of some classes of family symmetry and unification models

    International Nuclear Information System (INIS)

    Kane, Gordon L.; King, Steve F.; Peddie, Iain N.R.; Velasco-Sevilla, Liliana

    2005-01-01

    We review and compare theoretically and phenomenologically a number of possible family symmetries, which when combined with unification, could be important in explaining quark, lepton and neutrino masses and mixings, providing new results in several cases. Theoretical possibilities include abelian or non-abelian, symmetric or non symmetric Yukawa matrices, Grand Unification or not. Our main focus is on anomaly-free U(1) family symmetry combined with SU(5) unification, although we also discuss other possibilities. We provide a detailed phenomenological fit of the fermion masses and mixings for several examples, and discuss the supersymmetric flavour issues in such theories, including a detailed analysis of lepton flavour violation. We show that it is not possible to quantitatively and decisively discriminate between these different theoretical possibilities at the present time

  8. String unification and leptophobic Z` in flipped SU(5)

    Energy Technology Data Exchange (ETDEWEB)

    Lopez, J.L. [Rice Univ., Houston, TX (United States). Bonner Nuclear Labs.

    1997-01-01

    We summarize recent developments in the prediction for {alpha}{sub s}(M{sub Z}), self-consistent string unification and the dynamical determination of mass scales, and leptophobic Z` gauge bosons in the context of stringy flipped SU(5). (orig.).

  9. Extracting Characteristics of the Study Subjects from Full-Text Articles.

    Science.gov (United States)

    Demner-Fushman, Dina; Mork, James G

    Characteristics of the subjects of biomedical research are important in determining if a publication describing the research is relevant to a search. To facilitate finding relevant publications, MEDLINE citations provide Medical Subject Headings that describe the subjects' characteristics, such as their species, gender, and age. We seek to improve the recommendation of these headings by the Medical Text Indexer (MTI) that supports manual indexing of MEDLINE. To that end, we explore the potential of the full text of the publications. Using simple recall-oriented rule-based methods we determined that adding sentences extracted from the methods sections and captions to the abstracts prior to MTI processing significantly improved recall and F1 score with only a slight drop in precision. Improvements were also achieved in directly assigning several headings extracted from the full text. These results indicate the need for further development of automated methods capable of leveraging the full text for indexing.

  10. Ukrainian baroque editions of the 17th century in the fonds of VNLU

    Directory of Open Access Journals (Sweden)

    Kurganova O.

    2014-01-01

    Full Text Available The article observes the most outstanding Ukrainian baroque editions of the 17th century, deposited in the fonds of V. Vernadsky National Library of Ukraine. The main features of Ukranian literature baroque style that influenced the structure and design of these editions are defined. These features are: allegoric, emblematic, panegyric and theocentric nature of baroque art. Allegory is considered as a structure-forming element of a baroque edition. Emblem presents synthesis of visual and verbal means in baroque artistic book design. Panegyrics become a popular genre of baroque literature, being published as separate editions, as well as a structural part of other editions. Theocentric nature of baroque culture expresses itself mostly in poetic prayers, which function as a common element of preface or afterword to baroque editions. Ukrainian baroque editions are remarkable for their artistic design, which is closely connected to the content of a book.

  11. Australian Alps: Kosciuszko, Alpine and Namadgi National Parks (Second Edition

    Directory of Open Access Journals (Sweden)

    Nicole Porter

    2017-02-01

    Full Text Available Reviewed: Australian Alps: Kosciuszko, Alpine and Namadgi National Parks (Second Edition By Deidre Slattery. Clayton South, Australia: CSIRO Publishing, 2015. xvii + 302 pp. AU$ 45.00, US$ 35.95. ISBN 978-1-486-30171-3.

  12. Peer-editing Practice in the Writing Classroom: Benefits and Drawbacks

    Directory of Open Access Journals (Sweden)

    Ann Rosnida Md. Deni

    2011-01-01

    Full Text Available Small scale studies have shown that peer-editing is beneficial to students as it increases their awareness of the complex process of writing, it improves their knowledge of and skills in writing and helps them become more autonomous in learning. Teachers too may benefit from peer-editing as this practice discloses invaluable information on students’ writing weaknesses and strengths: and teachers’ teaching effectiveness. This is a small scale study conducted on fifteen first-year degree students majoring in Tourism to view the usefulness of peer-editing practice in enhancing their writing skills. Retrospective notes were taken to record students’ receptiveness and reaction towards peer editing practice: students writing samples and peer- editing questionnaires were analyzed to view students’ revisions and comments; and an open— ended questionnaire was distributed to identify students perceptions of peer—editing practice in the writing classroom. Analysis of data gathered revealed that peer-editing practice benefitted both the teacher and most of her students as it exposed important information that could improve her teaching of writing and her students’ writing practices. Data analysis also. however, discloses that peer-editing practice may have adverse effects on students’ motivation and improvement in writing if they are not deployed properly.

  13. Full-text publication of abstract-presented work in sport and exercise psychology.

    Science.gov (United States)

    Shue, Sarah; Warden, Stuart

    2018-01-01

    Meetings promote information sharing, but do not enable full dissemination of details. A systematic search was conducted for abstracts presented at the 2010 and 2011 Association of Applied Sport Psychology Annual Conferences to determine the full-text dissemination rate of work presented in abstract form and investigate factors influencing this rate. Systematic searches were sequentially conducted to determine whether the abstract-presented work had been published in full-text format in the 5 years following presentation. If a potential full-text publication was identified, information from the conference abstract (eg, results, number of participants in the sample(s), measurement tools used and so on) was compared with the full text to ensure the two entities represented the same body of work. Abstract factors of interest were assessed using logistic regression. Ninety-four out of 423 presented abstracts (22.2%) were published in full text. Odds of full-text publication increased if the abstract was from an international institution, presented in certain conference sections or presented as a lecture. Those attending professional conferences should be cautious when translating data presented at conferences into their applied work because of the low rate of peer-reviewed and full-text publication of the information.

  14. Grand unification: quo vadis domine

    International Nuclear Information System (INIS)

    Senjanovic, G.

    1985-01-01

    The present theoretical and experimental situation with grand unification is summarized. The issues of proton decay and the Weinberg angle are addressed, going through the predictions of both the standard SU(5) theory and its supersymmetric extension. The SO(10) theory, which provides a minimal one family model, is then studied. The gravitational characteristics of domain walls and strings are then discussed. It is argued that there is a need to go beyond SO(10) in order to incorporate a unified picture of families. This leads to the prediction of mirror fermions, whose physics is analyzed. 31 refs

  15. Einstein's Last Dream: The Space–Time Unification of Fundamental ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 3; Issue 1. Einstein's Last Dream: The Space – Time Unification of Fundamental Forces. Abdus Salam. Reflections Volume 3 Issue 1 January 1998 pp 81-88. Fulltext. Click here to view fulltext PDF. Permanent link:

  16. Educational Systems and Rising Inequality: Eastern Germany after Unification

    Science.gov (United States)

    von Below, Susanne; Powell, Justin J. W.; Roberts, Lance W.

    2013-01-01

    Educational systems considerably influence educational opportunities and the resulting social inequalities. Contrasting institutional regulations of both structures and contents, the authors present a typology of educational system types in Germany to analyze their effects on social inequality in eastern Germany after unification. After 1990, the…

  17. Interplay between grand unification and supersymmetry in SU(5 ...

    Indian Academy of Sciences (India)

    energy MSSM. break the rank, Aulakh and his collaborators [10–12] have showed that R-parity is exact all the way down to low energies. In this case, grand unification tells us something about supersymmetry and even dark matter. In this article ...

  18. Pharmspresso: a text mining tool for extraction of pharmacogenomic concepts and relationships from full text.

    Science.gov (United States)

    Garten, Yael; Altman, Russ B

    2009-02-05

    Pharmacogenomics studies the relationship between genetic variation and the variation in drug response phenotypes. The field is rapidly gaining importance: it promises drugs targeted to particular subpopulations based on genetic background. The pharmacogenomics literature has expanded rapidly, but is dispersed in many journals. It is challenging, therefore, to identify important associations between drugs and molecular entities--particularly genes and gene variants, and thus these critical connections are often lost. Text mining techniques can allow us to convert the free-style text to a computable, searchable format in which pharmacogenomic concepts (such as genes, drugs, polymorphisms, and diseases) are identified, and important links between these concepts are recorded. Availability of full text articles as input into text mining engines is key, as literature abstracts often do not contain sufficient information to identify these pharmacogenomic associations. Thus, building on a tool called Textpresso, we have created the Pharmspresso tool to assist in identifying important pharmacogenomic facts in full text articles. Pharmspresso parses text to find references to human genes, polymorphisms, drugs and diseases and their relationships. It presents these as a series of marked-up text fragments, in which key concepts are visually highlighted. To evaluate Pharmspresso, we used a gold standard of 45 human-curated articles. Pharmspresso identified 78%, 61%, and 74% of target gene, polymorphism, and drug concepts, respectively. Pharmspresso is a text analysis tool that extracts pharmacogenomic concepts from the literature automatically and thus captures our current understanding of gene-drug interactions in a computable form. We have made Pharmspresso available at http://pharmspresso.stanford.edu.

  19. The New Edition of Chopin’s Correspondence

    Directory of Open Access Journals (Sweden)

    Helman-Bednarczyk Zofia

    2016-12-01

    Full Text Available Some of Fryderyk Chopin’s letters were published individually or in groups already in the 2nd half of the 19th century. With the passage of time, more letters from and to Chopin were printed in monographs dedicated to his life and work. The first editions of Chopin’s collected letters come from the 1st half of the 20th century (by Scharlitt and von Guttry in Germany, Henryk Opieński – in Poland. B.E. Sydow’s Fryderyk Chopin’s Correspondence of 1955 continues to be used as the basic source edition by Chopin biographers. It has many strong points, but has become largely outdated.

  20. Beyond Author-Centricity in Scholarly Editing

    Directory of Open Access Journals (Sweden)

    Hans Walter Gabler

    2012-03-01

    Full Text Available Authorship – authority – authorisation – the author – the author’s will – the author’s intention: these form a cluster of notions whose validity for scholarly editing I fundamentally question. Taking measure from a historical survey of the discipline’s principles and practice from their institution under the dominance of stemmatics up to their main present-day ‘author orientation’ (Shillingsburg 1996, I see the need to split the terms ‘author’ and ‘authorship’ into a pragmatic versus a conceptual aspect. What textual scholarship engages with, directly and tangibly, is not authors but texts (and equally not works but texts, materially inscribed in transmissions. In the materiality and artifice of texts, ‘authoriality’ is accessible conceptually only, in a manner analog-ous to the Foucauldian ‘author function’. Under such premises, as well, ‘authority’, ‘authorisation’ and ‘authorial intention’ become recognisable as exogenous to texts, not integral to them. Consequently, I propose to abandon ‘authority’, ‘authorisation’ and ‘authorial intention’ as overriding principles and arbiters in editorial scholarship. Scholarly editing instead should re-situate itself in relation to texts, to textual criticism, to literary criticism and to literary theory alike, and do so by re-focussing the method-ology of its own practice. It should relinquish the external props termed ‘authorised document’, ‘textual authority’, or ‘authorial intention’ hitherto deferred to. Instead, it should revitalise skills fundamental to inherited editorial scholarship, namely those of critically assessing, and of editorially realising, textual validity. To re-embed editorial scholarship in literary criticism and theory, moreover, the interpretative and hermeneutic dimensions of textual criticism and scholarly editing will need to be freshly mapped.

  1. Full text and figure display improves bioscience literature search.

    Science.gov (United States)

    Divoli, Anna; Wooldridge, Michael A; Hearst, Marti A

    2010-04-14

    When reading bioscience journal articles, many researchers focus attention on the figures and their captions. This observation led to the development of the BioText literature search engine, a freely available Web-based application that allows biologists to search over the contents of Open Access Journals, and see figures from the articles displayed directly in the search results. This article presents a qualitative assessment of this system in the form of a usability study with 20 biologist participants using and commenting on the system. 19 out of 20 participants expressed a desire to use a bioscience literature search engine that displays articles' figures alongside the full text search results. 15 out of 20 participants said they would use a caption search and figure display interface either frequently or sometimes, while 4 said rarely and 1 said undecided. 10 out of 20 participants said they would use a tool for searching the text of tables and their captions either frequently or sometimes, while 7 said they would use it rarely if at all, 2 said they would never use it, and 1 was undecided. This study found evidence, supporting results of an earlier study, that bioscience literature search systems such as PubMed should show figures from articles alongside search results. It also found evidence that full text and captions should be searched along with the article title, metadata, and abstract. Finally, for a subset of users and information needs, allowing for explicit search within captions for figures and tables is a useful function, but it is not entirely clear how to cleanly integrate this within a more general literature search interface. Such a facility supports Open Access publishing efforts, as it requires access to full text of documents and the lifting of restrictions in order to show figures in the search interface.

  2. Infrared fixed point solution for the top quark mass and unification of couplings in the MSSM

    International Nuclear Information System (INIS)

    Bardeen, W.A.; Carena, M.; Pokorski, S.; Wagner, C.E.M.

    1993-08-01

    We analyze the implications of the infrared quasi fixed point solution for the top quark mass in the Minimal Supersymmetric Standard Model. This solution could explain in a natural way the relatively large value of the top quark mass and, if confirmed experimentally, may be suggestive of the onset of nonperturbative physics at very high energy scales. In the framework of grand unification, the expected bottom quark -- tau lepton Yukawa coupling unification is very sensitive to the fixed point structure of the top quark mass. For the presently allowed values of the electroweak parameters and the bottom quark mass, the Yukawa coupling unification implies that the top quark mass must be within ten percent of its fixed point values

  3. Investigating and Annotating the Role of Citation in Biomedical Full-Text Articles.

    Science.gov (United States)

    Yu, Hong; Agarwal, Shashank; Frid, Nadya

    2009-11-01

    Citations are ubiquitous in scientific articles and play important roles for representing the semantic content of a full-text biomedical article. In this work, we manually examined full-text biomedical articles to analyze the semantic content of citations in full-text biomedical articles. After developing a citation relation schema and annotation guideline, our pilot annotation results show an overall agreement of 0.71, and here we report on the research challenges and the lessons we've learned while trying to overcome them. Our work is a first step toward automatic citation classification in full-text biomedical articles, which may contribute to many text mining tasks, including information retrieval, extraction, summarization, and question answering.

  4. Introduction to unification of electromagnetic and weak interactions

    International Nuclear Information System (INIS)

    Martin, F.

    1980-01-01

    After reviewing the present status of weak interaction phenomenology we discuss the basic principles of gauge theories. Then we show how Higgs mechanism can give massive quanta of interaction. The so-called 'Weinberg-Salam' model, which unifies electromagnetic and weak interactions, is described. We conclude with a few words on unification with strong interactions and gravity [fr

  5. A4 family symmetry and quark-lepton unification

    International Nuclear Information System (INIS)

    King, Stephen F.; Malinsky, Michal

    2007-01-01

    We present a model of quark and lepton masses and mixings based on A 4 family symmetry, a discrete subgroup of an SO(3) flavour symmetry, together with Pati-Salam unification. It accommodates tri-bimaximal neutrino mixing via constrained sequential dominance with a particularly simple vacuum alignment mechanism emerging through the effective D-term contributions to the scalar potential

  6. Multilingual access to full text databases; Acces multilingue aux bases de donnees en texte integral

    Energy Technology Data Exchange (ETDEWEB)

    Fluhr, C; Radwan, K [Institut National des Sciences et Techniques Nucleaires (INSTN), Centre d` Etudes de Saclay, 91 - Gif-sur-Yvette (France)

    1990-05-01

    Many full text databases are available in only one language, or more, they may contain documents in different languages. Even if the user is able to understand the language of the documents in the database, it could be easier for him to express his need in his own language. For the case of databases containing documents in different languages, it is more simple to formulate the query in one language only and to retrieve documents in different languages. This paper present the developments and the first experiments of multilingual search, applied to french-english pair, for text data in nuclear field, based on the system SPIRIT. After reminding the general problems of full text databases search by queries formulated in natural language, we present the methods used to reformulate the queries and show how they can be expanded for multilingual search. The first results on data in nuclear field are presented (AFCEN norms and INIS abstracts). 4 refs.

  7. Edition and visual culture: Brás Cubas and its multiple incarnations

    Directory of Open Access Journals (Sweden)

    Raquel Castedo

    2013-09-01

    Full Text Available The article has as an exemplary object the book of Machado de AssisMemórias Póstumas de Brás Cubas, published in different editions, to problematize the relations between texts and the materiality of the media that they are published. Evaluates the role of design as a praxis of editorial mediation, having in sight the scope of visual studies and reading practices. It is a theorical reflexion that has a foundation on bibliographical research and that appropriates reproductions of pages from different editions as visual arguments articulated with the debated topics. Also presents data about the ways of reading/access to the text obtained as a mean of questionary and interviews.

  8. The string unification of gauge couplings and gauge kinetic mixings

    International Nuclear Information System (INIS)

    Hattori, Chuichiro; Matsuda, Masahisa; Matsuoka, Takeo; Mochinaga, Daizo.

    1993-01-01

    In the superstring models we have not only the complete 27 multiplets of E 6 but also extra incomplete (27+27-bar) chiral supermultiplets being alive at low energies. Associated with these additional multiplets, when the gauge symmetry contains more than one U(1) gauge group, there may exist gauge kinetic mixings among these U(1) gauge groups. In such cases the effect of gauge kinetic mixings should be incorporated into the study of unification of gauge couplings. We study these interesting effects systematically in these models. The string threshold effect is also taken into account. It is found that in the four-generation models we do not have an advisable solution of string unification of gauge couplings consistent with experimental values at the electroweak scale. We also discuss the possible scenarios to solve this problem. (author)

  9. Full-Text Linking: Affiliated versus Nonaffiliated Access in a Free Database.

    Science.gov (United States)

    Grogg, Jill E.; Andreadis, Debra K.; Kirk, Rachel A.

    2002-01-01

    Presents a comparison of access to full-text articles from a free bibliographic database (PubSCIENCE) for affiliated and unaffiliated users. Found that affiliated users had access to more full-text articles than unaffiliated users had, and that both types of users could increase their level of access through additional searching and greater…

  10. Family unification within SO(15)

    International Nuclear Information System (INIS)

    Enqvist, K.; Maalampi, J.

    1981-01-01

    We present a model for the unification of fermion families based on the gauge symmetry SO(15). It is a minimal SO(n) model which can accommodate the known fermions within a single irreducible representation. The model predicts four ordinary fermion families and four families of mirror fermions. The latter have V + A weak interactions, and their mass scale is predicted to be 10 2 GeV/c 2 . We argue that radiative corrections to the fermion masses can cause non-negligible mixing between ordinary and mirror fermions. The implications of these mixings for the weak interaction phenomenology and solar neutrinos are discussed. (orig.)

  11. Store Norske Leksikon: Defining a New Role for an Edited Encyclopaedia

    Directory of Open Access Journals (Sweden)

    Georg Kjøll

    2014-06-01

    Full Text Available Store norske leksikon (SNL [Great Norwegian Encyclopaedia] is an edited, online encyclopaedia that strives towards radical transparency. Our aim is for as many parts of text production as possible to be visible to everyone, much like in the model that Wikipedia has pioneered. Unlike Wikipedia, however, contributors to SNL are required to use their full name, and encouraged to supply biographies that explain their background and qualifications within a field or topic.

  12. SERVICES OF FULL-TEXT SEARCHING IN A DISTRIBUTED INFORMATION ENVIRONMENT (PROJECT HUMANITARIANA

    Directory of Open Access Journals (Sweden)

    S. K. Lyapin

    2015-01-01

    Full Text Available Problem statement. We justify the possibility of full-text search services application in both universal and specialized (in terms of resource base digital libraries for the extraction and analysis of the context knowledge in the humanities. The architecture and services of virtual information and resource center for extracting knowledge from the humanitarian texts generated by «Humanitariana» project are described. The functional integration of the resources and services for a full-text search in a distributed decentralized environment, organized in the Internet / Intranet architecture under the control of the client (user browser accessing a variety of independent servers. An algorithm for a distributed full-text query implementation is described. Methods. Method of combining requency-ranked and paragraph-oriented full-text queries is used: the first are used for the preliminary analysis of the subject area or a combination product (explication of "vertical" context, or macro context, the second - for the explication of "horizontal" context, or micro context within copyright paragraph. The results of the frequency-ranked queries are used to compile paragraph-oriented queries. Results. The results of textual research are shown on the topics "The question of fact in Russian philosophy", "The question of loneliness in Russian philosophy and culture". About 50 pieces of context knowledge on the total resource base of about 2,500 full-text resources have been explicated and briefly described to their further expert investigating. Practical significance. The proposed technology (advanced full-text searching services in a distributed information environment can be used for the information support of humanitarian studies and education in the humanities, for functional integration of resources and services of various organizations, for carrying out interdisciplinary research.

  13. Approximating the edit distance for genomes with duplicate genes under DCJ, insertion and deletion

    Directory of Open Access Journals (Sweden)

    Shao Mingfu

    2012-12-01

    Full Text Available Abstract Computing the edit distance between two genomes under certain operations is a basic problem in the study of genome evolution. The double-cut-and-join (DCJ model has formed the basis for most algorithmic research on rearrangements over the last few years. The edit distance under the DCJ model can be easily computed for genomes without duplicate genes. In this paper, we study the edit distance for genomes with duplicate genes under a model that includes DCJ operations, insertions and deletions. We prove that computing the edit distance is equivalent to finding the optimal cycle decomposition of the corresponding adjacency graph, and give an approximation algorithm with an approximation ratio of 1.5 + ∈.

  14. Unification of reactor elastomeric sealing based on material

    International Nuclear Information System (INIS)

    Sinha, N.K.; Raj, Baldev

    2012-01-01

    The unification of elastomeric sealing applications of Indian nuclear reactors based on a few qualified fluoroelastomer/perfluoroelastomer compounds and standardized approaches for finite element analysis (FEA) based design, manufacturing process and antifriction coatings is discussed. It is shown that the advance polymer architecture based Viton ® formulation developed for inflatable seals of 500 MWe Prototype Fast Breeder Reactor (PFBR) and its four basic variations can encompass other sealing applications of PFBR with minimum additional efforts on development and validation. Changing the blend ratio of Viton ® GBL 200S and 600S in inflatable seal formulation could extend its use to Pressurized Heavy Water Reactors (PHWRs). The higher operating temperature of Advanced Heavy Water Reactor (AHWR) seals expands the choice to perfluoroelastomers. FEA based on plane-strain/axisymmetric modeling (with Mooney–Rivlin as the basic constitutive model), seal manufacture by cold feed extrusion and injection molding as well as plasma Teflon-like coating belonging to two variations obtained from the development of inflatable seals provide the necessary standardization for unification. The gains in simplification of design, development and operation of seals along with the enhancements of safety and reliability are expected to be substantial.

  15. Unification of three linear models for the transient visual system

    NARCIS (Netherlands)

    Brinker, den A.C.

    1989-01-01

    Three different linear filters are considered as a model describing the experimentally determined triphasic impulse responses of discs. These impulse responses arc associated with the transient visual system. Each model reveals a different feature of the system. Unification of the models is

  16. Law behind second law of thermodynamics - unification with cosmology

    International Nuclear Information System (INIS)

    Nielsen, Holger B.; Ninomiya, Masao

    2006-01-01

    In an abstract setting of a general classical mechanical system as a model for the universe we set up a general formalism for a law behind the second law of thermodynamics, i.e. really for 'initial conditions'. We propose a unification with the other laws by requiring similar symmetry and locality properties

  17. Neutrino masses and b - τ unification in the supersymmetric standard model

    International Nuclear Information System (INIS)

    Vissani, F.; Smirnov, A.Yu.

    1994-05-01

    There are several indications that the Majorana masses of the right-handed neutrino components, M R , are at the intermediate scale: M R ∼ (10 10 - 10 12 ) GeV or even lighter. The renormalization effects due to large Yukawa couplings of neutrinos from region of momenta M R G are studied in the supersymmetric standard model. It is shown that neutrino renormalization effect can increase the m b /m τ ratio up to (10/15)%. This strongly disfavors m b - m τ unification for low values of tan β s . Lower bound on M R and tan β from the b - τ unification condition were found. The implications of the results to the see-saw mechanism of the neutrino mass generation are discussed. (author). 17 refs, 4 figs

  18. Re-editing and Censoring of Detectors in Negative Selection Algorithm

    Directory of Open Access Journals (Sweden)

    X.Z. Gao

    2009-12-01

    Full Text Available The Negative Selection Algorithm (NSA is a kind of novelty detection method inspired by the biological self/nonself discrimination principles. In this paper, we propose two new schemes for the detectors re-editing and censoring in the NSA. The detectors that fail to pass the negative selection phase are re-edited and updated to become qualified using the Differential Evolution (DE method. In the detectors censoring, the qualification of all the detectors is evaluated, and only those appropriate ones are retained. Prior knowledge of the anomalous data is utilized to discriminate the detectors so that their anomaly detection performances can be improved. The effectiveness of our detectors re-editing and censoring approaches is examined with both artificial signals and a practical bearings fault detection problem.

  19. Problems of CP-violation in early unification theories

    International Nuclear Information System (INIS)

    Liparteliani, A.G.; Monich, V.A.; Volkov, G.G.

    1985-01-01

    The present work studies possible mechanisms of P and CP-violation in the frames of an approach based on early unification of fundamental local symmetries, i.e., Pati-Salam four-colour symmetry, extended weak isotopic symmetry and that of quark-lepton generations. The work also studies the influence of generations mixing on the rates of rare processes in each of 3 classes of interactions

  20. Government Contract Law (9th Edition)

    Science.gov (United States)

    1987-04-01

    This Ninth Edition, like its predecessors, will serve as the textbook for the Government Contract Law taught at the School of Systems and Logistics...drawn from Government Contract Law -Cases, 1987 edition, for a rounded approach to the subject. This edition of the text includes coverage of the...Government Contract Law complements the Federal Acquisition Regulation and provides a preventive law treatment for contracting personnel. While it may

  1. SU(8) family unification with boson-fermion balance

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    Grand unification has been intensively investigated for over forty years, and many different approaches have been tried. In this talk I propose a model that involves three ingredients that do not appear in the usual constructions: (1) boson--fermion balance without full supersymmetry, (2) canceling the spin 1/2 fermion gauge anomalies against the anomaly from a gauged spin 3/2 gravitino, and (3) using a scalar field representation with non-zero U(1) generator to break the SU(8) gauge symmetry through a ground state which, before dynamical symmetry breaking, has a periodic U(1) generator structure. The model has a number of promising features: (1) natural incorporation of three families, (2) incorporation of the experimentally viable flipped SU(5) model, (3) a symmetry breaking pathway to the standard model using the scalar field required by boson-fermion balance, together with a stage of most attractive channel dynamical symmetry breaking, without postulating additional Higgs fields, (4) vanishing of bare Yuk...

  2. FTP: Full-Text Publishing?

    Science.gov (United States)

    Jul, Erik

    1992-01-01

    Describes the use of file transfer protocol (FTP) on the INTERNET computer network and considers its use as an electronic publishing system. The differing electronic formats of text files are discussed; the preparation and access of documents are described; and problems are addressed, including a lack of consistency. (LRW)

  3. The Flip Sides of Full-Text: Superindex and the Harvard Business Review/Online.

    Science.gov (United States)

    Dadlez, Eva M.

    1984-01-01

    This article illustrates similarities between two different types of full-text databases--Superindex, Harvard Business Review/Online--and uses them as arena to demonstrate search and display applications of full-text. The selection of logical operators, full-text search strategies, and keywords and Bibliographic Retrieval Service's Occurrence…

  4. A comprehensive and quantitative comparison of text-mining in 15 million full-text articles versus their corresponding abstracts.

    Science.gov (United States)

    Westergaard, David; Stærfeldt, Hans-Henrik; Tønsberg, Christian; Jensen, Lars Juhl; Brunak, Søren

    2018-02-01

    Across academia and industry, text mining has become a popular strategy for keeping up with the rapid growth of the scientific literature. Text mining of the scientific literature has mostly been carried out on collections of abstracts, due to their availability. Here we present an analysis of 15 million English scientific full-text articles published during the period 1823-2016. We describe the development in article length and publication sub-topics during these nearly 250 years. We showcase the potential of text mining by extracting published protein-protein, disease-gene, and protein subcellular associations using a named entity recognition system, and quantitatively report on their accuracy using gold standard benchmark data sets. We subsequently compare the findings to corresponding results obtained on 16.5 million abstracts included in MEDLINE and show that text mining of full-text articles consistently outperforms using abstracts only.

  5. Weitere Texte physiognomischen Inhalts

    Directory of Open Access Journals (Sweden)

    Böck, Barbara

    2004-12-01

    Full Text Available The present article offers the edition of three cuneiform texts belonging to the Akkadian handbook of omens drawn from the physical appearance as well as the morals and behaviour of man. The book comprising up to 27 chapters with more than 100 omens each was entitled in antiquity Alamdimmû. The edition of the three cuneiform tablets completes, thus, the author's monographic study on the ancient Mesopotamian divinatory discipline of physiognomy (Die babylonisch-assyrische Morphoskopie (Wien 2000 [=AfO Beih. 27].

    En este artículo se presenta la editio princeps de tres textos cuneiformes conservados en el British Museum (Londres y el Vorderasiatisches Museum (Berlín, que pertenecen al libro asirio-babilonio de presagios fisiognómicos. Este libro, titulado originalmente Alamdimmû ('forma, figura', consta de 27 capítulos, cada uno con más de cien presagios escritos en lengua acadia. Los tres textos completan así el estudio monográfico de la autora sobre la disciplina adivinatoria de la fisiognomía en el antiguo Oriente (Die babylonisch-assyrische Morphoskopie (Wien 2000 [=AfO Beih. 27].

  6. Book Review: New Perspectives on Technical Editing

    Science.gov (United States)

    Murphy, A. J. (Ed.); Sterken, Christiaan

    2012-08-01

    New Perspectives on Technical Editing by Avon J. Murphy (ed.) ISBN : 978-0895033949 (2010) Baywood Publishing Company Inc, Hardcover, 210 pages, 35.5 GBP This book presents a collection of 10 chapters dealing with diverse aspects of technical editing (ie, editorial planning, and analysis and structural changes made to other people's technological documents): research in technical editing, trends and teaching of technical editing, copyediting, and technical journal editing. The role and function of the modern journal and book editor is also dealt with in detail. Each chapter is written by an expert in the field: senior editors, university professors in technical communication, technical writers and linguists. The ever-evolving role of the editor is clearly elucidated in several historical reviews, and in the descriptions of the expectations for the future. A very striking aspect of this book is its extensive collection of bibliographic resources: every chapter lists dozens of very useful references, and the closing chapter, and annotated bibliography, contain many not so well known references, and are most useful. All in all, the book is a treasure trove listing more than 400 references, in addition to numerous webpage URLs embedded in the texts. The book is designed to help the reader to understand current practices and norms in technical editing, and to help to take action in editing as well as in teaching and educating would-be editors. The audience for this book thus includes editors and teachers, but also writers, researchers and students. A deep reading of this book will result in a better understanding of the difference between full technical editing and its much narrower component so well known as copyediting, and will convince any prospective editor that editing should not be undertaken if the people involved do not master the art of precision and accuracy in technical (as well as in human) communication, do not possess the technical know how and computer

  7. Astrophysical Probes of Varying Constants and Unification

    International Nuclear Information System (INIS)

    Martins, C J A P

    2016-01-01

    The observational evidence for the acceleration of the universe demonstrates that canonical theories of gravitation and particle physics are incomplete, if not incorrect. A new generation of astronomical facilities will soon carry out precision consistency tests of the standard cosmological model and search for evidence of new physics beyond it. I describe recent work of CAUP's Dark Side team on some of these tests, focusing on the stability of nature's fundamental couplings and tests of unification scenarios. (paper)

  8. Analysis of the Length of Braille Texts in English Braille American Edition, the Nemeth Code, and Computer Braille Code versus the Unified English Braille Code

    Science.gov (United States)

    Knowlton, Marie; Wetzel, Robin

    2006-01-01

    This study compared the length of text in English Braille American Edition, the Nemeth code, and the computer braille code with the Unified English Braille Code (UEBC)--also known as Unified English Braille (UEB). The findings indicate that differences in the length of text are dependent on the type of material that is transcribed and the grade…

  9. Supersymmetry, supergravity, and unification

    CERN Document Server

    Nath, Pran

    2017-01-01

    This unique book gives a modern account of particle physics and gravity based on supersymmetry and supergravity, two of the most significant developments in theoretical physics since general relativity. The book begins with a brief overview of the history of unification and then goes into a detailed exposition of both fundamental and phenomenological topics. The topics in fundamental physics include Einstein gravity, Yang-Mills theory, anomalies, the standard model, supersymmetry and supergravity, and the construction of supergravity couplings with matter and gauge fields, as well as computational techniques for SO(10) couplings. The topics of phenomenological interest include implications of supergravity models at colliders, CP violation, and proton stability, as well as topics in cosmology such as inflation, leptogenesis, baryogenesis, and dark matter. The book is intended for graduate students and researchers seeking to master the techniques for building grand unified models.

  10. SSRF-PDM and its full-text retrieval improvement

    International Nuclear Information System (INIS)

    Tong Xingfan; Deng Huiyu; Li Zhiming

    2011-01-01

    Project and data management is essential for Shanghai Synchrotron Radiation Facility (SSRF) which is a huge scientific platform for science research and technology development in China. With Product Data Management (PDM) system, SSRF improves its information service greatly. In this paper, we introduce the network structure, configuration modules and client terminals of the PDM system and the improvement in full-text retrieval subsystem, including its algorithms and details of implement in order to optimize the retrieval system.(authors)

  11. Subject Retrieval from Full-Text Databases in the Humanities

    Science.gov (United States)

    East, John W.

    2007-01-01

    This paper examines the problems involved in subject retrieval from full-text databases of secondary materials in the humanities. Ten such databases were studied and their search functionality evaluated, focusing on factors such as Boolean operators, document surrogates, limiting by subject area, proximity operators, phrase searching, wildcards,…

  12. A comprehensive and quantitative comparison of text-mining in 15 million full-text articles versus their corresponding abstracts

    Science.gov (United States)

    Westergaard, David; Stærfeldt, Hans-Henrik

    2018-01-01

    Across academia and industry, text mining has become a popular strategy for keeping up with the rapid growth of the scientific literature. Text mining of the scientific literature has mostly been carried out on collections of abstracts, due to their availability. Here we present an analysis of 15 million English scientific full-text articles published during the period 1823–2016. We describe the development in article length and publication sub-topics during these nearly 250 years. We showcase the potential of text mining by extracting published protein–protein, disease–gene, and protein subcellular associations using a named entity recognition system, and quantitatively report on their accuracy using gold standard benchmark data sets. We subsequently compare the findings to corresponding results obtained on 16.5 million abstracts included in MEDLINE and show that text mining of full-text articles consistently outperforms using abstracts only. PMID:29447159

  13. Searching Harvard Business Review Online. . . Lessons in Searching a Full Text Database.

    Science.gov (United States)

    Tenopir, Carol

    1985-01-01

    This article examines the Harvard Business Review Online (HBRO) database (bibliographic description fields, abstracts, extracted information, full text, subject descriptors) and reports on 31 sample HBRO searches conducted in Bibliographic Retrieval Services to test differences between searching full text and searching bibliographic record. Sample…

  14. A comprehensive and quantitative comparison of text-mining in 15 million full-text articles versus their corresponding abstracts

    DEFF Research Database (Denmark)

    Westergaard, David; Stærfeldt, Hans Henrik; Tønsberg, Christian

    2018-01-01

    Across academia and industry, text mining has become a popular strategy for keeping up with the rapid growth of the scientific literature. Text mining of the scientific literature has mostly been carried out on collections of abstracts, due to their availability. Here we present an analysis of 15...... subcellular associations using a named entity recognition system, and quantitatively report on their accuracy using gold standard benchmark data sets. We subsequently compare the findings to corresponding results obtained on 16.5 million abstracts included in MEDLINE and show that text mining of full...... million English scientific full-text articles published during the period 1823-2016. We describe the development in article length and publication sub-topics during these nearly 250 years. We showcase the potential of text mining by extracting published protein-protein, disease-gene, and protein...

  15. Medical writing, revising and editing

    DEFF Research Database (Denmark)

    Pilegaard, Morten

    2006-01-01

    The globalization of science makes medical writing, editing and revision a rapidly growing field of linguistic study and practice. Medical science texts are written according to uniform, general guidelines and medical genres have become highly conventionalized in terms of structure and linguistic...... form. Medical editing often takes the form of peer review and mainly addresses issues of contents and overall validity. Medical revision incorporates the checking of the macrostructure and the microstructure of the text, its language and style and its suitability for the target reader or client...

  16. Genesis of Electroweak Unification and the Higgs

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    I will give a historical account of the developments leading up to the unification of weak and electromagnetic interactions, as I saw them from my standpoint in Imperial College London. I will describe the state of physics in the 1950s, the aim of finding a unified theory of various interactions, the obstacles encountered in trying to unify the weak and electromagnetic interactions, and their eventual resolution, with a brief discussion of the later history culminating in the discovery of the Higgs boson in 2012.

  17. Unification of electromagnetic, strong and weak interaction

    International Nuclear Information System (INIS)

    Duong Van Phi; Duong Anh Duc

    1993-09-01

    The Unification of Electromagnetic, Strong and Weak Interactions is realized in the framework of the Quantum Field Theory, established in an 8-dimensional Unified Space. Two fundamental, spinor and vector field equations are considered. The first of the matter particles and the second is of the gauge particles. Interaction Lagrangians are formed from the external and internal currents and the external and internal vector field operators. Generators of the local gauge transformations are the combinations of the matrices of the first field equation. (author). 15 refs

  18. Unification of Radio Galaxies and their Accretion Jet Properties

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... We investigate the relation between black hole mass, bh, and jet power, jet, for a sample of BL Lacs and radio quasars. We find that BL Lacs are separated from radio quasars by the FR I/II dividing line in bh-jet plane, which strongly supports the unification scheme of FR I/BL Lac and FR II/radio ...

  19. Unification of Radio Galaxies and their Accretion Jet Properties ...

    Indian Academy of Sciences (India)

    Abstract. We investigate the relation between black hole mass, Mbh, and jet power, Qjet, for a sample of BL Lacs and radio quasars. We find that BL Lacs are separated from radio quasars by the FR I/II dividing line in Mbh–Qjet plane, which strongly supports the unification scheme of FR. I/BL Lac and FR II/radio quasar.

  20. Natural fermion mass hierarchy and mixings in family unification

    International Nuclear Information System (INIS)

    Dent, James B.; Feger, Robert; Kephart, Thomas W.; Nandi, S.

    2011-01-01

    We present an SU(9) model of family unification with three light chiral families, and a natural hierarchy of charged fermion masses and mixings. The existence of singlet right handed neutrinos with masses about two orders of magnitude smaller than the GUT scale, as needed to understand the light neutrinos masses via the see-saw mechanism, is compelling in our model.

  1. Relict gravitational waves in the expanding Universe model and the grand unification scale

    International Nuclear Information System (INIS)

    Veryskin, A.V.; Rubakov, V.A.; Sazhin, M.V.

    1983-01-01

    The amplification of the vacuum fluctuations of the metric in the model of the expanding Universe was considered. The spectrum of the relict gravitational waves was chosen to be independent from the details of an evolution of the Universe after the phase transition. It is shown that the expanding Universe scenario is compatible with the experimental data on the anisotropy of the microwave background only if the vacuum energy density of the symmetric phase is much less than the Planck one. The theories of grand unification with not large values of the unification scale (one and a half order less than the Planck mass) are preferable from the point of view of cosmology

  2. The CRISPR/Cas genome-editing tool: application in improvement of crops

    Directory of Open Access Journals (Sweden)

    SURENDER eKHATODIA

    2016-04-01

    Full Text Available The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR associated Cas9/sgRNA system is a novel fledgling targeted genome-editing technique from bacterial immune system, which is a cheap, easy and most rapidly adopted genome editing tool transforming to revolutionary paradigm. Cas9 protein is an RNA guided endonuclease utilized for creating targeted double stranded breaks with only a short RNA sequence to confer recognition of the target in animals and plants. Development of genetically edited (GE crops similar to those developed by conventional or mutation breeding using this potential technique makes it a promising and extremely versatile tool for providing sustainable productive agriculture for better feeding of rapidly growing population in changing climate. The emerging areas of research for the genome editing in plants are like, interrogating gene function, rewiring the regulatory signaling networks, sgRNA library for high-throughput loss-of-function screening. In this review, we will discuss the broad applicability of the Cas9 nuclease mediated targeted plant genome editing for development of designer crops. The regulatory uncertainty and social acceptance of plant breeding by Cas9 genome editing have also been discussed. The non-GM designer genetically edited plants could prospect climate resilient and sustainable energy agriculture in coming future for maximizing the yield by combating abiotic and biotic stresses with this new innovative plant breeding technique.

  3. Gauge-Higgs Unification Models in Six Dimensions with S2/Z2 Extra Space and GUT Gauge Symmetry

    Directory of Open Access Journals (Sweden)

    Cheng-Wei Chiang

    2012-01-01

    Full Text Available We review gauge-Higgs unification models based on gauge theories defined on six-dimensional spacetime with S2/Z2 topology in the extra spatial dimensions. Nontrivial boundary conditions are imposed on the extra S2/Z2 space. This review considers two scenarios for constructing a four-dimensional theory from the six-dimensional model. One scheme utilizes the SO(12 gauge symmetry with a special symmetry condition imposed on the gauge field, whereas the other employs the E6 gauge symmetry without requiring the additional symmetry condition. Both models lead to a standard model-like gauge theory with the SU(3×SU(2L×U(1Y(×U(12 symmetry and SM fermions in four dimensions. The Higgs sector of the model is also analyzed. The electroweak symmetry breaking can be realized, and the weak gauge boson and Higgs boson masses are obtained.

  4. The unification of powerful radio-loud AGN: the multi-wavelength balance

    NARCIS (Netherlands)

    Podigachoski, Pece; Barthel, Peter; Haas, Martin; Leipski, Christian; Wilkes, Belinda; Rocca-Volmerange, Brigitte; Drouart, Guillaume

    2016-01-01

    Powerful radio-loud AGN, by virtue of their optically-thin low-frequency radio emission, represent unique targets in orientation-based unification studies, and in searches for orientation indicators and orientation invariants. Central in these efforts is the landmark Third Cambridge Catalog of Radio

  5. Simple Genome Editing of Rodent Intact Embryos by Electroporation.

    Directory of Open Access Journals (Sweden)

    Takehito Kaneko

    Full Text Available The clustered regularly interspaced short palindromic repeat (CRISPR/CRISPR-associated (Cas system is a powerful tool for genome editing in animals. Recently, new technology has been developed to genetically modify animals without using highly skilled techniques, such as pronuclear microinjection of endonucleases. Technique for animal knockout system by electroporation (TAKE method is a simple and effective technology that produces knockout rats by introducing endonuclease mRNAs into intact embryos using electroporation. Using TAKE method and CRISPR/Cas system, the present study successfully produced knockout and knock-in mice and rats. The mice and rats derived from embryos electroporated with Cas9 mRNA, gRNA and single-stranded oligodeoxynucleotide (ssODN comprised the edited targeted gene as a knockout (67% of mice and 88% of rats or knock-in (both 33%. The TAKE method could be widely used as a powerful tool to produce genetically modified animals by genome editing.

  6. Infrared fixed points and fixed lines in the top-bottom-tau sector in supersymmetric grand unification

    International Nuclear Information System (INIS)

    Schrempp, B.

    1994-10-01

    The two loop 'top-down' renormalization group flow for the top, bottom and tau Yukawa couplings, from μ=M GUT ≅O(10 16 GeV) to μ≅m t , is explored in the framework of supersymmetric grand unification; reproduction of the physical bottom and tau masses is required. Instead of following the recent trend of implementing exact Yukawa coupling unification i) a search for infrared (IR) fixed lines and fixed points in the m t pole -tan β plane is performed and ii) the extent to which these imply approximate Yukawa unification is determined. In the m t pole -tan β plane two IR fixed lines, intersecting in an IR fixed point, are located. The more attractive fixed line has a branch of almost constant top mass, m t pole ≅168≅180 GeV (close to the experimental value), for the large interval 2.5 GUT approximately. The less attractive fixed line as well as the fixed point at m t pole ≅170 GeV, tan β≅55 implement approximate top-bottom Yukawa unification at all scales μ. The renormalization group flow is attracted towards the IR fixed point by way of the more attractive IR fixed line. The fixed point and lines are distinct from the much quoted effective IR fixed point m t pole ≅O(200 GeV) sin β. (orig.)

  7. Gauge coupling unification in heterotic string models with gauge mediated supersymmetry breaking

    International Nuclear Information System (INIS)

    Anandakrishnan, Archana; Raby, Stuart

    2011-01-01

    We calculate the weak scale minimal supersymmetric standard model spectrum starting from a heterotic string theory compactified on an anisotropic orbifold. Supersymmetry breaking is mediated by vectorlike exotics that arise naturally in heterotic string theories. The messengers that mediate supersymmetry breaking come in incomplete grand unified theory (GUT) multiplets and give rise to nonuniversal gaugino masses at the GUT scale. Models with nonuniversal gaugino masses at the GUT scale have the attractive feature of allowing for precision gauge coupling unification at the GUT scale with negligible contributions from threshold corrections near the unification scale. The unique features of this minimally supersymmetric standard model spectrum are light gluinos and also large mass differences between the lightest and the next-to-lightest neutralinos and charginos which could lead to interesting signatures at the colliders.

  8. Quark-lepton unification and proton decay

    International Nuclear Information System (INIS)

    Pati, J.C.; Salam, A.

    1980-05-01

    Complexions for proton decay arising within a maximal symmetry for quark-lepton unification, which leads to spontaneous rather than intrinsic violations of B, L and F are considered. Four major modes satisfying δB=-1 and δF=0, -2, -4 and -6 are noted. It is stressed that some of these modes can coexist in accord with allowed solutions for renormalization group equations for coupling constants for a class of unifying symmetries. None of these remarks is dependent on the nature of quark charges. It is noted that if quarks and leptons are made of constituent preons, the preon binding is likely to be magnetic. (author)

  9. Local grand unification and string theory

    International Nuclear Information System (INIS)

    Nilles, Hans Peter; Vaudrevange, Patrick K.S.

    2009-09-01

    The low energy effective action of string theory depends strongly on the process of compactification and the localization of fields in extra dimensions. Explicit string constructions towards the minimal supersymmetric standard model (MSSM) reveal interesting results leading to the concept of local grand unification. Properties of the MSSM indicate that we might live at a special location close to an orbifold fixed point rather than a generic point in Calabi-Yau moduli space. We observe an enhancement of (discrete) symmetries that have various implications for the properties of the MSSM such as proton stability as well as solutions to the flavor problem, the m-problem and the strong CP-problem. (orig.)

  10. Unification of fuel elements for research reactors

    International Nuclear Information System (INIS)

    Vatulyn, A.V.; Stetskyi, Y.A.; Dobrikova, I.V.

    1997-01-01

    To the purpose of fuel elements unification the possibility of rod fuel assembly (FA) using in the cores of research reactors have been considered in this paper. The calculation results of geometric, hydraulic and thermotechnical parameters of rod assembly are submitted. Several designs of finned square fuel element and fuel assembly are proposed on base of analysis of rod FA characteristics in compare of tube ones. The fuel elements specimens and the model assembly are manufactured. The developed designs are the basis for further optimization after neutron-physical calculations of cores. (author)

  11. Supersymmetry and supergravity: Phenomenology and grand unification

    International Nuclear Information System (INIS)

    Arnowitt, R.; Nath, P.

    1993-01-01

    A survey is given of supersymmetry and supergravity and their phenomenology. Some of the topics discussed are the basic ideas of global supersymmetry, the minimal supersymmetric Standard Model (MSSM) and its phenomenology, the basic ideas of local supersymmetry (supergravity), grand unification, supersymmetry breaking in supergravity grand unified models, radiative breaking of SU(2) x U(1), proton decay, cosmological constraints, and predictions of supergravity grand unified models. While the number of detailed derivations are necessarily limited, a sufficient number of results are given so that a reader can get a working knowledge of this field

  12. Les représentations de la réunification allemande dans l’ex-Yougoslavie

    Directory of Open Access Journals (Sweden)

    Laurent Hassid

    2012-06-01

    Full Text Available La réunification allemande a été perçue de manière différente dans les États de l’ex-Yougoslavie. En Serbie, république la plus peuplée de la Fédération et où se trouve le pouvoir central, elle est crainte comme le symbole d’une possible désintégration. En Croatie et en Slovénie s’est ainsi répandue l’idée que « si l’Allemagne peut se réunifier, la Yougoslavie peut bien se désintégrer » (Entretien avec Vladimir Radomirovic, ancien rédacteur en chef du quotidien serbe Politika et fondateur en 2009 de Pistaljka, site Internet qui dénonce la corruption dans les Balkans - www.pistaljka.rs. Au risque de provoquer une crise au sein de la CEE, l’Allemagne a poussé les autres grandes puissances du continent, dont la France, à reconnaître rapidement les indépendances des deux républiques. Pour comprendre les différentes représentations de la réunification allemande dans les Balkans, il est nécessaire d’étudier également les perceptions de la chute du Mur de Berlin, un an plus tôt. Symbole d’un communisme qui n’est pas tombé partout dans l’ex-Yougoslavie à partir de 1991, il a néanmoins grandement participé à la désintégration de la Fédération. Vingt ans après, l’Allemagne reste un acteur majeur dans la région, mais a abandonné une partie de son influence économique et politique au profit de l’Union européenne, notamment à partir de l’introduction de l’euro qui prend la place du mark, ancienne devise de référence.

  13. Full-text publication of abstracts presented at European Orthodontic Society congresses

    NARCIS (Netherlands)

    Livas, Christos; Pandis, Nikolaos; Ren, Yijin

    2014-01-01

    INTRODUCTION: Empirical evidence has indicated that only a subsample of studies conducted reach full-text publication and this phenomenon has become known as publication bias. A form of publication bias is the selectively delayed full publication of conference abstracts. The objective of this

  14. HMMEditor: a visual editing tool for profile hidden Markov model

    Directory of Open Access Journals (Sweden)

    Cheng Jianlin

    2008-03-01

    Full Text Available Abstract Background Profile Hidden Markov Model (HMM is a powerful statistical model to represent a family of DNA, RNA, and protein sequences. Profile HMM has been widely used in bioinformatics research such as sequence alignment, gene structure prediction, motif identification, protein structure prediction, and biological database search. However, few comprehensive, visual editing tools for profile HMM are publicly available. Results We develop a visual editor for profile Hidden Markov Models (HMMEditor. HMMEditor can visualize the profile HMM architecture, transition probabilities, and emission probabilities. Moreover, it provides functions to edit and save HMM and parameters. Furthermore, HMMEditor allows users to align a sequence against the profile HMM and to visualize the corresponding Viterbi path. Conclusion HMMEditor provides a set of unique functions to visualize and edit a profile HMM. It is a useful tool for biological sequence analysis and modeling. Both HMMEditor software and web service are freely available.

  15. Focus point gauge mediation in product group unification

    International Nuclear Information System (INIS)

    Bruemmer, Felix; Ibe, Masahiro; Tokyo Univ., Kashiwa; Yanagida, Tsutomu T.

    2013-03-01

    In certain models of gauge-mediated supersymmetry breaking with messenger fields in incomplete GUT multiplets, the radiative corrections to the Higgs potential cancel out during renormalization group running. This allows for relatively heavy superpartners and for a 125 GeV Higgs while the ne-tuning remains modest. In this paper, we show that such gauge mediation models with ''focus point'' behaviour can be naturally embedded into a model of SU(5) x U(3) product group unification.

  16. The World Health Organization Classification of dontogenic Lesions: A Summary of the Changes of the 2017 (4th Edition

    Directory of Open Access Journals (Sweden)

    Merva SOLUK-TEKKEŞİN

    2018-01-01

    Full Text Available The 4th edition of the World Health Organization (WHO Classification of Head and Neck Tumors was published in January 2017. The edition serves to provide an updated classification scheme, and extended genetic and molecular data that are useful as diagnostic tools for the lesions of the head and neck region. This review focuses on the most current update of odontogenic cysts and tumors based on the 2017 WHO edition. The updated classification has some important differences from the 3rd edition (2005, including a new classification of odontogenic cysts, ‘reclassified’ odontogenic tumors, and some new entities.

  17. A comparison of the first and second editions of the Dictionary of Literary Slovene

    Directory of Open Access Journals (Sweden)

    Simon Krek

    2014-12-01

    Full Text Available The paper investigates the differences between the first and second editions of the Dictionary of Literary Slovene (SSKJ. The analysis is two-fold: first, a detailed comparison of headword lists of both editions is conducted, followed by the comparison of 2,500 entries from both editions, consisting of a hundred entries for each letter. The analysis shows that the spelling and pronunciation changes to the entries in the second edition were made without the approval of any relevant language authority. Also, the changes introduced are random and inconsistent, and are affecting the consistency of lexicographic description of the first edition, especially on the grammatical level. Furthermore, the editorial decision to make identifying the source of lexicographic information (i.e. the first edition of SSKJ or the Dictionary of New Words of the Slovenian language impossible, raises doubts about lexicographic credibility of the second edition as a description of contemporary Slovene. From the lexicographic perspective, it would have been more appropriate to leave the first edition unchanged and the Dictionary of New Words of the Slovenian language as a separate publication. In addition, the second edition of SSKJ is not freely available online, and neither of the editions is freely available in the form of a dictionary database for natural language processing and other uses.

  18. REDIdb 3.0: A Comprehensive Collection of RNA Editing Events in Plant Organellar Genomes

    Directory of Open Access Journals (Sweden)

    Claudio Lo Giudice

    2018-04-01

    Full Text Available RNA editing is an important epigenetic mechanism by which genome-encoded transcripts are modified by substitutions, insertions and/or deletions. It was first discovered in kinetoplastid protozoa followed by its reporting in a wide range of organisms. In plants, RNA editing occurs mostly by cytidine (C to uridine (U conversion in translated regions of organelle mRNAs and tends to modify affected codons restoring evolutionary conserved aminoacid residues. RNA editing has also been described in non-protein coding regions such as group II introns and structural RNAs. Despite its impact on organellar transcriptome and proteome complexity, current primary databases still do not provide a specific field for RNA editing events. To overcome these limitations, we developed REDIdb a specialized database for RNA editing modifications in plant organelles. Hereafter we describe its third release containing more than 26,000 events in a completely novel web interface to accommodate RNA editing in its genomics, biological and evolutionary context through whole genome maps and multiple sequence alignments. REDIdb is freely available at http://srv00.recas.ba.infn.it/redidb/index.html

  19. An edit script for taxonomic classifications

    Directory of Open Access Journals (Sweden)

    Valiente Gabriel

    2005-08-01

    Full Text Available Abstract Background The NCBI taxonomy provides one of the most powerful ways to navigate sequence data bases but currently users are forced to formulate queries according to a single taxonomic classification. Given that there is not universal agreement on the classification of organisms, providing a single classification places constraints on the questions biologists can ask. However, maintaining multiple classifications is burdensome in the face of a constantly growing NCBI classification. Results In this paper, we present a solution to the problem of generating modifications of the NCBI taxonomy, based on the computation of an edit script that summarises the differences between two classification trees. Our algorithms find the shortest possible edit script based on the identification of all shared subtrees, and only take time quasi linear in the size of the trees because classification trees have unique node labels. Conclusion These algorithms have been recently implemented, and the software is freely available for download from http://darwin.zoology.gla.ac.uk/~rpage/forest/.

  20. Facilitating Full-text Access to Biomedical Literature Using Open Access Resources.

    Science.gov (United States)

    Kang, Hongyu; Hou, Zhen; Li, Jiao

    2015-01-01

    Open access (OA) resources and local libraries often have their own literature databases, especially in the field of biomedicine. We have developed a method of linking a local library to a biomedical OA resource facilitating researchers' full-text article access. The method uses a model based on vector space to measure similarities between two articles in local library and OA resources. The method achieved an F-score of 99.61%. This method of article linkage and mapping between local library and OA resources is available for use. Through this work, we have improved the full-text access of the biomedical OA resources.

  1. Evaluating Open-Source Full-Text Search Engines for Matching ICD-10 Codes.

    Science.gov (United States)

    Jurcău, Daniel-Alexandru; Stoicu-Tivadar, Vasile

    2016-01-01

    This research presents the results of evaluating multiple free, open-source engines on matching ICD-10 diagnostic codes via full-text searches. The study investigates what it takes to get an accurate match when searching for a specific diagnostic code. For each code the evaluation starts by extracting the words that make up its text and continues with building full-text search queries from the combinations of these words. The queries are then run against all the ICD-10 codes until a match indicates the code in question as a match with the highest relative score. This method identifies the minimum number of words that must be provided in order for the search engines choose the desired entry. The engines analyzed include a popular Java-based full-text search engine, a lightweight engine written in JavaScript which can even execute on the user's browser, and two popular open-source relational database management systems.

  2. Do Unification Models Explain the X-ray Properties of Radio Sources?

    NARCIS (Netherlands)

    Wilkes, Belinda J.; Kuraszkiewicz, J.; Haas, M.; Barthel, P.; Willner, S. P.; Leipski, C.; Worrall, D.; Birkinshaw, M.; Antonucci, R. R.; Ashby, M.; Chini, R.; Fazio, G. G.; Lawrence, C. R.; Ogle, P. M.; Schulz, B.

    Chandra observations of a complete, flux-limited sample of 38 high-redshift (1 Unification models and lead to estimates of the covering

  3. Grand unification: status report

    International Nuclear Information System (INIS)

    Georgi, H.

    1983-01-01

    Grand unification is reviewed with regard to the flavor puzzle and the hierarchy puzzle. Progress in CP and the PQWWKDFS axion is reviewed. The neutrino mass and B-L research, the understanding and assimilation of the language of effective theories (which divide the momentum scale up into regions), with focus on the models, are surveyed. Various unified models are organized according to whether they address the hierarchy puzzle or the flavor puzzle. SU(5), SO(10), E6, and Higgs are considered simple and explicit models. Global symmetry addresses hierarchy puzzle, but the rules are unclear. In SO (18), with regard to hierarchy, perturbation theory breaks down. SO (14) fails for hierarchy because of GIM, b and t problems. Supersymmetry and technicolor with regard to flavor puzzle are questioned. The CP solution of ETC and Composite C models (addressing both flavor and hierarchy) is a minus. Composite A model has no evident virtues, and the basic idea of ETC model needs checking

  4. [Laboratory unification: advantages and disadvantages for clinical microbiology].

    Science.gov (United States)

    Andreu, Antonia; Matas, Lurdes

    2010-10-01

    This article aims to reflect on which areas or tasks of microbiology laboratories could be unified with those of clinical biochemistry, hematology, immunology or pathology laboratories to benefit patients and the health system, as well as the areas that should remain independent since their amalgamation would not only fail to provide a benefit but could even jeopardize the quality of microbiological diagnosis, and consequently patient care. To do this, the distinct analytic phases of diagnosis are analyzed, and the advantages and disadvantages of amalgamation are evaluated in each phase. The pros and cons of the unification of certain areas such as the computer system, occupational risk units, customer service, purchasing logistics, and materials storage, etc, are also discussed. Lastly, the effect of unification on urgent microbiology diagnosis is analyzed. Microbiological diagnosis should be unique. The microbiologist should perform an overall evaluation of the distinct techniques used for a particular patient, both those that involve direct diagnosis (staining, culture, antigen detection techniques or molecular techniques) and indirect diagnosis (antibody detection). Moreover, the microbiology laboratory should be independent, with highly trained technicians and specialists in microbiology that provide added value as experts in infection and as key figures in the process of establishing a correct etiological diagnosis. Copyright © 2010 Elsevier España S.L. All rights reserved.

  5. UNIFICATION OF PROCESSES OF SORTING OUT OF DESTROYED CONSTRUCTION OBJECTS

    Directory of Open Access Journals (Sweden)

    SHATOV S. V.

    2015-09-01

    Full Text Available Summary. Problem statement. Technogenic catastrophes, failures or natural calamities, result in destruction of build objects. Under the obstructions of destructions can be victims. The most widespread technogenic failure is explosions of gas. The structure of obstructions changes and depends on parameters and direction of explosion, firstly its size and location of wreckages. Sorting out of obstructions is carried out with machines and mechanisms which do not meet the requirements of these works, that predetermines of carrying out of rescue or restoration works on imperfect scheme , especially on the initial stages, and it increases terms and labour intensiveness of their conduct. Development technological solution is needed for the effective sorting out of destructions of construction objects. Purpose. Development of unification solution on the improvement of technological processes of sorting out of destructions of buildings and constructions. Conclusion. The analysis of experience of works shows on sorting out of the destroyed construction objects, show that they are carried out on imperfect scheme, which do not take into account character of destruction of objects and are based on the use of construction machines which do not meet the requirements of these processes, and lead to considerable resource losses. Developed unified scheme of sorting out of the destroyed construction objects depending on character of their destruction and possibility of line of works, and also with the use of build machines with a multipurpose equipment, provide the increase of efficiency of carrying out of rescue and construction works.

  6. Human Resources Administration: A School-Based Perspective. Fourth Edition

    Science.gov (United States)

    Smith, Richard

    2009-01-01

    Enhanced and updated, this Fourth Edition of Richard E. Smith's highly successful text examines the growing role of the principal in planning, hiring, staff development, supervision, and other human resource functions. The Fourth Edition includes new sections on ethics, induction, and the role of the mentor teacher. This edition also introduces…

  7. An introduction to the edition of two Lemaître’s original manuscripts

    Directory of Open Access Journals (Sweden)

    Maere Catherine de

    2017-04-01

    Full Text Available The aim of this paper is to explain the contributions of G. Lemaître to Spinor Theory. At the end of the paper, we edited also, for the first time two short manuscripts: Spineurs et Quanta and Les spineurs et la physique quantique, written by Lemaître in December 1955 and in January 1956. This edition is a way of honouring Professor Michael Heller because he was the first, with Professor Odon Godart, who discovered, classified and published unedited manuscripts of G. Lemaître.

  8. Focus point gauge mediation in product group unification

    Energy Technology Data Exchange (ETDEWEB)

    Bruemmer, Felix [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Ibe, Masahiro [Tokyo Univ., Kashiwa (Japan). Kavli IPMU, TODIAS; Tokyo Univ., Kashiwa (Japan). ICRR; Yanagida, Tsutomu T. [Tokyo Univ., Kashiwa (Japan). Kavli IPMU, TODIAS

    2013-03-15

    In certain models of gauge-mediated supersymmetry breaking with messenger fields in incomplete GUT multiplets, the radiative corrections to the Higgs potential cancel out during renormalization group running. This allows for relatively heavy superpartners and for a 125 GeV Higgs while the ne-tuning remains modest. In this paper, we show that such gauge mediation models with ''focus point'' behaviour can be naturally embedded into a model of SU(5) x U(3) product group unification.

  9. Signatures of lower-scale gauge coupling unification in the standard model due to extended Higgs sector

    International Nuclear Information System (INIS)

    Chizhov, M. V.; Bednyakov, V. A.

    2016-01-01

    The gauge coupling unification can be achieved at a unification scale around 5×10"1"3 GeV if the Standard Model scalar sector is extended with extra Higgs-like doublets. The relevant new scalar degrees of freedom in the form of chiral Z* and W* vector bosons might “be visible” already at about 700 GeV. Their eventual preferred coupling to the heavy quarks explains the non observation of these bosons in the first LHC run and provides promising expectation for the second LHC run.

  10. Improving e-book access via a library-developed full-text search tool.

    Science.gov (United States)

    Foust, Jill E; Bergen, Phillip; Maxeiner, Gretchen L; Pawlowski, Peter N

    2007-01-01

    This paper reports on the development of a tool for searching the contents of licensed full-text electronic book (e-book) collections. The Health Sciences Library System (HSLS) provides services to the University of Pittsburgh's medical programs and large academic health system. The HSLS has developed an innovative tool for federated searching of its e-book collections. Built using the XML-based Vivísimo development environment, the tool enables a user to perform a full-text search of over 2,500 titles from the library's seven most highly used e-book collections. From a single "Google-style" query, results are returned as an integrated set of links pointing directly to relevant sections of the full text. Results are also grouped into categories that enable more precise retrieval without reformulation of the search. A heuristic evaluation demonstrated the usability of the tool and a web server log analysis indicated an acceptable level of usage. Based on its success, there are plans to increase the number of online book collections searched. This library's first foray into federated searching has produced an effective tool for searching across large collections of full-text e-books and has provided a good foundation for the development of other library-based federated searching products.

  11. Double unification of particles with fields and electricity with gravity in non-empty space of continuous complex energies

    Directory of Open Access Journals (Sweden)

    Bulyzhenkov Igor E.

    2016-01-01

    Full Text Available Non-empty space reading of Maxwell equations as local energy identities explains why a Coulomb field is carried rigidly by electrons in experiments. The analytical solution of the Poisson equation defines the sharp radial shape of charged elementary densities which are proportional to continuous densities of electric self-energy. Both Coulomb field and radial charge densities are free from energy divergences. Non-empty space of electrically charged mass-energy can be described by complex analytical densities resulting in real values for volume mass integrals and in imaginary values for volume charge integrals. Imaginary electric charges in the Newton gravitational law comply with real Coulomb forces. Unification of forces through complex charges rids them of radiation self-acceleration. Strong gravitational fields repeal probe bodies that might explainthe accelerated expansion of the dense Metagalaxy. Outward and inward spherical waves form the standing wave process within the radial carrier of complex energy.

  12. CRISPR-Cas9: tool for qualitative and quantitative plant genome editing

    Directory of Open Access Journals (Sweden)

    Ali Noman

    2016-11-01

    Full Text Available Genome editing advancements have made many unachievable ideas practical. Increased adoption of genome editing has been geared by swiftly developing CRISPR-Cas9 technology. This technique is appearing as driving force for innovative utilization in diverse branches of plant biology. CRISPR mediated genome editing is being used for rapid, easy and efficient alteration of indigenous genes among diverse plant species. With approximate completion of conceptual work about CRISPR/Cas9, plant scientists are applying this genome editing tool for crop attributes enhancement. The capability of CRISPR-Cas9 systems for performing targeted and efficient modifications in genome sequence as well as gene expression will certainly spur novel developments not only in model plants but also in crop plants. Additionally, due to non-involvement of foreign DNA, this technique may help alleviating regulatory issues associated with GM Plants. We expect that prevailing challenges in plant science like genomic region manipulation, crop specific vectors etc. will be addressed along with sustained growth of this genome editing tool. In this review, recent progress of CRISPR/Cas9 technology in plants has been summarized and discussed. We review potential of CRISPR/Cas9 for different aspects of plant life. It also covers strengths of this technique in comparison with other genome editing techniques e.g. ZFNs and TALENs and potential challenges in coming decades have been described.

  13. The software for automatic creation of the formal grammars used by speech recognition, computer vision, editable text conversion systems, and some new functions

    Science.gov (United States)

    Kardava, Irakli; Tadyszak, Krzysztof; Gulua, Nana; Jurga, Stefan

    2017-02-01

    For more flexibility of environmental perception by artificial intelligence it is needed to exist the supporting software modules, which will be able to automate the creation of specific language syntax and to make a further analysis for relevant decisions based on semantic functions. According of our proposed approach, of which implementation it is possible to create the couples of formal rules of given sentences (in case of natural languages) or statements (in case of special languages) by helping of computer vision, speech recognition or editable text conversion system for further automatic improvement. In other words, we have developed an approach, by which it can be achieved to significantly improve the training process automation of artificial intelligence, which as a result will give us a higher level of self-developing skills independently from us (from users). At the base of our approach we have developed a software demo version, which includes the algorithm and software code for the entire above mentioned component's implementation (computer vision, speech recognition and editable text conversion system). The program has the ability to work in a multi - stream mode and simultaneously create a syntax based on receiving information from several sources.

  14. Thesaurus of craft and professional terminology in Ukrainian bibliopegy: the issues of a special dictionary formation

    Directory of Open Access Journals (Sweden)

    Halchenko O.

    2015-01-01

    Full Text Available The article covers terminological problems which arise when medieval manuscripts’ bindings are described for scientific catalogs and electronic databases. The author attempts to analyze the causes of these problems and ways to overcome them. Reviewed are handwritten and printed sources, which contain the terms dealing with manuscripts production, and substantiated is the relevance of formation of the national craft and professional terminology thesaurus in Ukrainian codicology and bibliopegy. We have also defined the basic steps of the dictionary creation, which are the following: collecting special terms and creating a glossary and card index; translation, editing and unification of borrowed terms; creation of a digital visual dictionary

  15. Peer editing: a strategic source in EFL students’ writing process

    Directory of Open Access Journals (Sweden)

    Nubia Mercedes Díaz Galvis

    2011-06-01

    Full Text Available This article reports on a research project focused on peer editing as a pedagogical tool to promote collaborative assessment in the EFL writing process. With teachers overstretched in the Bogotá public school system, a method needed to be found that would allow students to receive much needed feedback without overtaxing the teachers` resources. Peer editing, a phenomenon that often occurs naturally within the classroom, was therefore systematically implemented as a solution to the stated problem. The main aims of this study, conducted with a group of ninth grade student at a public school in Bogotá, were to determine the role of peer editing in the writing process and to characterize the relationships built when students corrected each others writings. The instruments used for collecting data were field notes, video recordings and students’ artifacts. The results showed that when students were engaged in peer editing sessions they created zones of proximal development in which high achiever students provided linguistic scaffolding and empowered low achievers. It was also found that students used thinking strategies such as noticing and explaining when they identified errors related to the formal aspects of the language.

  16. 'Transatlantic Print Culture, 1880-1940: Emerging Media, Emerging Modernisms', edited by Ann Ardis and Patrick Collier

    Directory of Open Access Journals (Sweden)

    Janet Floyd

    2009-11-01

    Full Text Available A review of 'Transatlantic Print Culture, 1880-1940: Emerging Media, Emerging Modernisms', edited by Ann Ardis and Patrick Collier (London: Palgrave Macmillan, 2008. Hardback, 259 pages, £50, ISBN 9780554269.

  17. The vacuum of the minimal nonsupersymmetric SO(10) unification

    International Nuclear Information System (INIS)

    Bertolini, Stefano; Di Luzio, Luca; Malinsky, Michal

    2010-01-01

    We study a class of nonsupersymmetric SO(10) grand-unified scenarios where the first stage of the symmetry breaking is driven by the vacuum expectation values of the 45-dimensional adjoint representation. Three-decade-old results claim that such a Higgs setting may lead exclusively to the flipped SU(5) x U(1) intermediate stage. We show that this conclusion is actually an artifact of the tree-level potential. The study of the accidental global symmetries emerging in various limits of the scalar potential offers a simple understanding of the tree-level result and a rationale for the drastic impact of quantum corrections. We scrutinize in detail the simplest and paradigmatic case of the 45 H +16 H Higgs sector triggering the breaking of SO(10) to the standard electroweak model. We show that the minimization of the one-loop effective potential allows for intermediate SU(4) C x SU(2) L x U(1) R and SU(3) c x SU(2) L x SU(2) R x U(1) B-L symmetric stages as well. These are the options favored by gauge unification. Our results, that apply whenever the SO(10) breaking is triggered by H >, open the path for hunting the simplest realistic scenario of nonsupersymmetric SO(10) grand unification.

  18. Genome Editing with Crispr-Cas9 Systems: Basic Research and Clinical Applications

    Directory of Open Access Journals (Sweden)

    Anna Meiliana

    2017-04-01

    Full Text Available BACKGROUND: Recently established genome editing technologies will open new avenues for biological research and development. Human genome editing is a powerful tool which offers great scientific and therapeutic potential. CONTENT: Genome editing using the clustered regularly interspaced short palindromic repeats (CRISPR/CRISPRassociated protein 9 (Cas9 technology is revolutionizing the gene function studies and possibly will give rise to an entirely new degree of therapeutics for a large range of diseases. Prompt advances in the CRISPR/Cas9 technology, as well as delivery modalities for gene therapy applications, are dismissing the barriers to the clinical translation of this technology. Many studies conducted showed promising results, but as current available technologies for evaluating off-target gene modification, several elements must be addressed to validate the safety of the CRISPR/Cas9 platform for clinical application, as the ethical implication as well. SUMMARY: The CRISPR/Cas9 system is a powerful genome editing technology with the potential to create a variety of novel therapeutics for a range of diseases, many of which are currently untreatable. KEYWORDS: genome editing, CRISPR-Cas, guideRNA, DSB, ZFNs, TALEN

  19. A Novel Parallel Algorithm for Edit Distance Computation

    Directory of Open Access Journals (Sweden)

    Muhammad Murtaza Yousaf

    2018-01-01

    Full Text Available The edit distance between two sequences is the minimum number of weighted transformation-operations that are required to transform one string into the other. The weighted transformation-operations are insert, remove, and substitute. Dynamic programming solution to find edit distance exists but it becomes computationally intensive when the lengths of strings become very large. This work presents a novel parallel algorithm to solve edit distance problem of string matching. The algorithm is based on resolving dependencies in the dynamic programming solution of the problem and it is able to compute each row of edit distance table in parallel. In this way, it becomes possible to compute the complete table in min(m,n iterations for strings of size m and n whereas state-of-the-art parallel algorithm solves the problem in max(m,n iterations. The proposed algorithm also increases the amount of parallelism in each of its iteration. The algorithm is also capable of exploiting spatial locality while its implementation. Additionally, the algorithm works in a load balanced way that further improves its performance. The algorithm is implemented for multicore systems having shared memory. Implementation of the algorithm in OpenMP shows linear speedup and better execution time as compared to state-of-the-art parallel approach. Efficiency of the algorithm is also proven better in comparison to its competitor.

  20. Data Editing and Imputation in Business Surveys Using “R”

    Directory of Open Access Journals (Sweden)

    Elena Romascanu

    2014-06-01

    Full Text Available Purpose – Missing data are a recurring problem that can cause bias or lead to inefficient analyses. The objective of this paper is a direct comparison between the two statistical software features R and SPSS, in order to take full advantage of the existing automated methods for data editing process and imputation in business surveys (with a proper design of consistency rules as a partial alternative to the manual editing of data. Approach – The comparison of different methods on editing surveys data, in R with the ‘editrules’ and ‘survey’ packages because inside those, exist commonly used transformations in official statistics, as visualization of missing values pattern using ‘Amelia’ and ‘VIM’ packages, imputation approaches for longitudinal data using ‘VIMGUI’ and a comparison of another statistical software performance on the same features, such as SPSS. Findings – Data on business statistics received by NIS’s (National Institute of Statistics are not ready to be used for direct analysis due to in-record inconsistencies, errors and missing values from the collected data sets. The appropriate automatic methods from R packages, offers the ability to set the erroneous fields in edit-violating records, to verify the results after the imputation of missing values providing for users a flexible, less time consuming approach and easy to perform automation in R than in SPSS Macros syntax situations, when macros are very handy.

  1. UKPMC: a full text article resource for the life sciences.

    Science.gov (United States)

    McEntyre, Johanna R; Ananiadou, Sophia; Andrews, Stephen; Black, William J; Boulderstone, Richard; Buttery, Paula; Chaplin, David; Chevuru, Sandeepreddy; Cobley, Norman; Coleman, Lee-Ann; Davey, Paul; Gupta, Bharti; Haji-Gholam, Lesley; Hawkins, Craig; Horne, Alan; Hubbard, Simon J; Kim, Jee-Hyub; Lewin, Ian; Lyte, Vic; MacIntyre, Ross; Mansoor, Sami; Mason, Linda; McNaught, John; Newbold, Elizabeth; Nobata, Chikashi; Ong, Ernest; Pillai, Sharmila; Rebholz-Schuhmann, Dietrich; Rosie, Heather; Rowbotham, Rob; Rupp, C J; Stoehr, Peter; Vaughan, Philip

    2011-01-01

    UK PubMed Central (UKPMC) is a full-text article database that extends the functionality of the original PubMed Central (PMC) repository. The UKPMC project was launched as the first 'mirror' site to PMC, which in analogy to the International Nucleotide Sequence Database Collaboration, aims to provide international preservation of the open and free-access biomedical literature. UKPMC (http://ukpmc.ac.uk) has undergone considerable development since its inception in 2007 and now includes both a UKPMC and PubMed search, as well as access to other records such as Agricola, Patents and recent biomedical theses. UKPMC also differs from PubMed/PMC in that the full text and abstract information can be searched in an integrated manner from one input box. Furthermore, UKPMC contains 'Cited By' information as an alternative way to navigate the literature and has incorporated text-mining approaches to semantically enrich content and integrate it with related database resources. Finally, UKPMC also offers added-value services (UKPMC+) that enable grantees to deposit manuscripts, link papers to grants, publish online portfolios and view citation information on their papers. Here we describe UKPMC and clarify the relationship between PMC and UKPMC, providing historical context and future directions, 10 years on from when PMC was first launched.

  2. Neutrino masses and the unification of the SO(10) families

    International Nuclear Information System (INIS)

    Maalampi, J.; Enqvist, K.

    1980-01-01

    We show that the unification of the SO(10) families in SO(10+m) group can offer a solution to the neutrino mass problem. For simplicity we have restricted our analysis to SO(11), which contains - aside from generation mixing -the main novel feature of the theories of this kind: fermions that couple by V+A charged weak currents. (author)

  3. The Gift Network: Dave Eggers and the Circulation of Second Editions

    Directory of Open Access Journals (Sweden)

    Jacqueline O’Dell

    2017-07-01

    Full Text Available This article argues for a view of the gift as an affective network and investigates how Dave Eggers’s practice of publishing second editions works to produce this network. Framing my discussion of the gift with Sara Ahmed’s work on affective economies, I suggest that the gift, like affect, is best understood as a surplus effect of circulation. I argue that Eggers negotiates the gift’s double bind by emphasizing the impossibility of identifying a “pure” gift or an authoritative “original” edition; his double editions show how the gift survives through the surplus values generated by their ongoing circulation. Eggers's symbolic and material gift network ultimately depends on the uncertainty and mystification emblematic of Eggers’s anxious aesthetic and mode of recirculation, adding to critical conversations that position Eggers’s aesthetic within movements of new sincerity or post-irony.

  4. The Edit Distance as a Measure of Perceived Rhythmic Similarity

    Directory of Open Access Journals (Sweden)

    Olaf Post

    2012-07-01

    Full Text Available The ‘edit distance’ (or ‘Levenshtein distance’ measure of distance between two data sets is defined as the minimum number of editing operations – insertions, deletions, and substitutions – that are required to transform one data set to the other (Orpen and Huron, 1992. This measure of distance has been applied frequently and successfully in music information retrieval, but rarely in predicting human perception of distance. In this study, we investigate the effectiveness of the edit distance as a predictor of perceived rhythmic dissimilarity under simple rhythmic alterations. Approaching rhythms as a set of pulses that are either onsets or silences, we study two types of alterations. The first experiment is designed to test the model’s accuracy for rhythms that are relatively similar; whether rhythmic variations with the same edit distance to a source rhythm are also perceived as relatively similar by human subjects. In addition, we observe whether the salience of an edit operation is affected by its metric placement in the rhythm. Instead of using a rhythm that regularly subdivides a 4/4 meter, our source rhythm is a syncopated 16-pulse rhythm, the son. Results show a high correlation between the predictions by the edit distance model and human similarity judgments (r = 0.87; a higher correlation than for the well-known generative theory of tonal music (r = 0.64. In the second experiment, we seek to assess the accuracy of the edit distance model in predicting relatively dissimilar rhythms. The stimuli used are random permutations of the son’s inter-onset intervals: 3-3-4-2-4. The results again indicate that the edit distance correlates well with the perceived rhythmic dissimilarity judgments of the subjects (r = 0.76. To gain insight in the relationships between the individual rhythms, the results are also presented by means of graphic phylogenetic trees.

  5. tagtog: interactive and text-mining-assisted annotation of gene mentions in PLOS full-text articles.

    Science.gov (United States)

    Cejuela, Juan Miguel; McQuilton, Peter; Ponting, Laura; Marygold, Steven J; Stefancsik, Raymund; Millburn, Gillian H; Rost, Burkhard

    2014-01-01

    The breadth and depth of biomedical literature are increasing year upon year. To keep abreast of these increases, FlyBase, a database for Drosophila genomic and genetic information, is constantly exploring new ways to mine the published literature to increase the efficiency and accuracy of manual curation and to automate some aspects, such as triaging and entity extraction. Toward this end, we present the 'tagtog' system, a web-based annotation framework that can be used to mark up biological entities (such as genes) and concepts (such as Gene Ontology terms) in full-text articles. tagtog leverages manual user annotation in combination with automatic machine-learned annotation to provide accurate identification of gene symbols and gene names. As part of the BioCreative IV Interactive Annotation Task, FlyBase has used tagtog to identify and extract mentions of Drosophila melanogaster gene symbols and names in full-text biomedical articles from the PLOS stable of journals. We show here the results of three experiments with different sized corpora and assess gene recognition performance and curation speed. We conclude that tagtog-named entity recognition improves with a larger corpus and that tagtog-assisted curation is quicker than manual curation. DATABASE URL: www.tagtog.net, www.flybase.org.

  6. Improving e-book access via a library-developed full-text search tool*

    Science.gov (United States)

    Foust, Jill E.; Bergen, Phillip; Maxeiner, Gretchen L.; Pawlowski, Peter N.

    2007-01-01

    Purpose: This paper reports on the development of a tool for searching the contents of licensed full-text electronic book (e-book) collections. Setting: The Health Sciences Library System (HSLS) provides services to the University of Pittsburgh's medical programs and large academic health system. Brief Description: The HSLS has developed an innovative tool for federated searching of its e-book collections. Built using the XML-based Vivísimo development environment, the tool enables a user to perform a full-text search of over 2,500 titles from the library's seven most highly used e-book collections. From a single “Google-style” query, results are returned as an integrated set of links pointing directly to relevant sections of the full text. Results are also grouped into categories that enable more precise retrieval without reformulation of the search. Results/Evaluation: A heuristic evaluation demonstrated the usability of the tool and a web server log analysis indicated an acceptable level of usage. Based on its success, there are plans to increase the number of online book collections searched. Conclusion: This library's first foray into federated searching has produced an effective tool for searching across large collections of full-text e-books and has provided a good foundation for the development of other library-based federated searching products. PMID:17252065

  7. Advances in genome editing for improved animal breeding: A review

    Directory of Open Access Journals (Sweden)

    Shakil Ahmad Bhat

    2017-11-01

    Full Text Available Since centuries, the traits for production and disease resistance are being targeted while improving the genetic merit of domestic animals, using conventional breeding programs such as inbreeding, outbreeding, or introduction of marker-assisted selection. The arrival of new scientific concepts, such as cloning and genome engineering, has added a new and promising research dimension to the existing animal breeding programs. Development of genome editing technologies such as transcription activator-like effector nuclease, zinc finger nuclease, and clustered regularly interspaced short palindromic repeats systems begun a fresh era of genome editing, through which any change in the genome, including specific DNA sequence or indels, can be made with unprecedented precision and specificity. Furthermore, it offers an opportunity of intensification in the frequency of desirable alleles in an animal population through gene-edited individuals more rapidly than conventional breeding. The specific research is evolving swiftly with a focus on improvement of economically important animal species or their traits all of which form an important subject of this review. It also discusses the hurdles to commercialization of these techniques despite several patent applications owing to the ambiguous legal status of genome-editing methods on account of their disputed classification. Nonetheless, barring ethical concerns gene-editing entailing economically important genes offers a tremendous potential for breeding animals with desirable traits.

  8. Building a protein name dictionary from full text: a machine learning term extraction approach

    Directory of Open Access Journals (Sweden)

    Campagne Fabien

    2005-04-01

    Full Text Available Abstract Background The majority of information in the biological literature resides in full text articles, instead of abstracts. Yet, abstracts remain the focus of many publicly available literature data mining tools. Most literature mining tools rely on pre-existing lexicons of biological names, often extracted from curated gene or protein databases. This is a limitation, because such databases have low coverage of the many name variants which are used to refer to biological entities in the literature. Results We present an approach to recognize named entities in full text. The approach collects high frequency terms in an article, and uses support vector machines (SVM to identify biological entity names. It is also computationally efficient and robust to noise commonly found in full text material. We use the method to create a protein name dictionary from a set of 80,528 full text articles. Only 8.3% of the names in this dictionary match SwissProt description lines. We assess the quality of the dictionary by studying its protein name recognition performance in full text. Conclusion This dictionary term lookup method compares favourably to other published methods, supporting the significance of our direct extraction approach. The method is strong in recognizing name variants not found in SwissProt.

  9. Introduction to nuclear science, second edition

    CERN Document Server

    Bryan, Jeff C.

    2013-01-01

    This book was written to provide students who have limited backgrounds in the physical sciences and math with an accessible textbook on nuclear science. Expanding on the foundation of the bestselling first edition, Introduction to Nuclear Science, Second Edition provides a clear and complete introduction to nuclear chemistry and physics, from basic concepts to nuclear power and medical applications. Incorporating suggestions from professors using this book for their courses, the author has created a new text that is approximately 60 percent larger and more comprehensive and flexible than the first.New to This Edition: Thorough review of nuclear forensics, radiology, gamma cameras, and decay through proton or neutron emission More detailed explanations of the necessary mathematics A chapter on dosimetry of radiation fields Expanded discussion of applications, introduced earlier in the text More in-depth coverage of nuclear reactors, including a new chapter examining more reactor types, their safety systems,...

  10. Light higgsino for gauge coupling unification

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Kwang Sik, E-mail: ksjeong@pusan.ac.kr

    2017-06-10

    We explore gauge coupling unification and dark matter in high scale supersymmetry where the scale of supersymmetry breaking is much above the weak scale. The gauge couplings unify as precisely as in low energy supersymmetry if the higgsinos, whose mass does not break supersymmetry, are much lighter than those obtaining masses from supersymmetry breaking. The dark matter of the universe can then be explained by the neutral higgsino or the gravitino. High scale supersymmetry with light higgsinos requires a large Higgs mixing parameter for electroweak symmetry breaking to take place. It is thus naturally realized in models where superparticle masses are generated at loop level while the Higgs mixing parameter is induced at tree level, like in anomaly and gauge mediation of supersymmetry breaking.

  11. The Extent of mRNA Editing Is Limited in Chicken Liver and Adipose, but Impacted by Tissular Context, Genotype, Age, and Feeding as Exemplified with a Conserved Edited Site in COG3

    Directory of Open Access Journals (Sweden)

    Pierre-François Roux

    2016-02-01

    Full Text Available RNA editing is a posttranscriptional process leading to differences between genomic DNA and transcript sequences, potentially enhancing transcriptome diversity. With recent advances in high-throughput sequencing, many efforts have been made to describe mRNA editing at the transcriptome scale, especially in mammals, yielding contradictory conclusions regarding the extent of this phenomenon. We show, by detailed description of the 25 studies focusing so far on mRNA editing at the whole-transcriptome scale, that systematic sequencing artifacts are considered in most studies whereas biological replication is often neglected and multi-alignment not properly evaluated, which ultimately impairs the legitimacy of results. We recently developed a rigorous strategy to identify mRNA editing using mRNA and genomic DNA sequencing, taking into account sequencing and mapping artifacts, and biological replicates. We applied this method to screen for mRNA editing in liver and white adipose tissue from eight chickens and confirm the small extent of mRNA recoding in this species. Among the 25 unique edited sites identified, three events were previously described in mammals, attesting that this phenomenon is conserved throughout evolution. Deeper investigations on five sites revealed the impact of tissular context, genotype, age, feeding conditions, and sex on mRNA editing levels. More specifically, this analysis highlighted that the editing level at the site located on COG3 was strongly regulated by four of these factors. By comprehensively characterizing the mRNA editing landscape in chickens, our results highlight how this phenomenon is limited and suggest regulation of editing levels by various genetic and environmental factors.

  12. T.J. Kriel (original compiler, D.J. Prinsloo and B.P. Sathekge (compilers revised edition. Popular Northern Sotho Dictionary

    Directory of Open Access Journals (Sweden)

    Kwena J. Mashamaite

    2011-10-01

    Full Text Available The compilers of this new edition have successfully highlighted the important additions to the last edition of the dictionary. It is important to inform prospective users about new information. It is also a marketing strategy to announce the contents of a new product in both the preface and at the back of the cover page, as is the case with this dictionary.

  13. Low-luminosity Blazars in Wise: A Mid-infrared View of Unification

    Science.gov (United States)

    Plotkin, Richard M.; Anderson, S. F.; Brandt, W. N.; Markoff, S.; Shemmer, O.; Wu, J.

    2012-01-01

    We use the preliminary data release from the Wide-Field Infrared Survey Explorer (WISE) to perform the first statistical study on the mid-infrared (IR) properties of a large number ( 102) of BL Lac objects -- low-luminosity Active Galactic Nuclei (AGN) with a jet beamed toward the Earth. As expected, many BL Lac objects are so highly beamed that their jet synchrotron emission dominates their IR spectral energy distributions (SEDs), and the shape of their SEDs in the IR correlates well with SED peak frequency. In other BL Lac objects, the jet is not strong enough to completely dilute the rest of the AGN, and we do not see observational signatures of the dusty torus from these weakly beamed BL Lac objects. While at odds with simple unification, the missing torus is consistent with recent suggestions that BL Lac objects are fed by radiatively inefficient accretion flows. We discuss implications on the ``nature vs. nurture" debate for FR I and FR II galaxies, and also on the standard orientation-based AGN unification model.

  14. Efficient extraction of protein-protein interactions from full-text articles.

    Science.gov (United States)

    Hakenberg, Jörg; Leaman, Robert; Vo, Nguyen Ha; Jonnalagadda, Siddhartha; Sullivan, Ryan; Miller, Christopher; Tari, Luis; Baral, Chitta; Gonzalez, Graciela

    2010-01-01

    Proteins and their interactions govern virtually all cellular processes, such as regulation, signaling, metabolism, and structure. Most experimental findings pertaining to such interactions are discussed in research papers, which, in turn, get curated by protein interaction databases. Authors, editors, and publishers benefit from efforts to alleviate the tasks of searching for relevant papers, evidence for physical interactions, and proper identifiers for each protein involved. The BioCreative II.5 community challenge addressed these tasks in a competition-style assessment to evaluate and compare different methodologies, to make aware of the increasing accuracy of automated methods, and to guide future implementations. In this paper, we present our approaches for protein-named entity recognition, including normalization, and for extraction of protein-protein interactions from full text. Our overall goal is to identify efficient individual components, and we compare various compositions to handle a single full-text article in between 10 seconds and 2 minutes. We propose strategies to transfer document-level annotations to the sentence-level, which allows for the creation of a more fine-grained training corpus; we use this corpus to automatically derive around 5,000 patterns. We rank sentences by relevance to the task of finding novel interactions with physical evidence, using a sentence classifier built from this training corpus. Heuristics for paraphrasing sentences help to further remove unnecessary information that might interfere with patterns, such as additional adjectives, clauses, or bracketed expressions. In BioCreative II.5, we achieved an f-score of 22 percent for finding protein interactions, and 43 percent for mapping proteins to UniProt IDs; disregarding species, f-scores are 30 percent and 55 percent, respectively. On average, our best-performing setup required around 2 minutes per full text. All data and pattern sets as well as Java classes that

  15. Full-text publication of abstracts in emergency medicine in Denmark.

    Science.gov (United States)

    Ravn, Anne Katrine; Petersen, Dan Brun; Folkestad, Lars; Hallas, Peter; Brabrand, Mikkel

    2014-05-24

    Abstracts presented at medical conferences or scientific meetings should ideally be published as full-text articles in peer-reviewed journals after initial presentation and feedback regardless of the findings. The aim of this survey was to determine the publication rate of papers presented at the Danish Emergency Medicine Conferences in 2009, 2010 and 2011. Abstracts presented at the conferences were identified and authors contacted to obtain publication information. A further search was conducted using relevant databases. Publication rates for the 2009 and 2010 were approximately 30% (25-31.6%). The publication rate for the 2011 conference was 14.5% within 18 months with an additional 9% under review prior to publication. When comparing full-text publication rates from DEMC to previous international studies in EM Danish EM research community has similar publication rates. However, other more established specialties have higher publication levels. Knowledge of reasons for non-publication could lead to efforts to promote publication like funding; the possibility of discussion between authors and editors at conferences; "publication mentors"; and/or research courses provided by the Danish Society of Emergency Medicine.

  16. Exchange-Rate Unification with Black Market Leakages; Russia 1992

    OpenAIRE

    Linda S. Goldberg

    1993-01-01

    In 1992 Russia unified the multiple exchange rates that had applied to international transactions. This paper describes the multiple exchange rate system that existed in Russia prior to mid-1992 and undertakes a theoretical exploration of the effects of the exchange rate unification that took place in July 1992. The model developed here allows for leakages between official and black markets and permits flexibility of the exchange rates in both official and parallel currency markets. Within th...

  17. Yukawa unification in moduli-dominant SUSY breaking

    International Nuclear Information System (INIS)

    Khalil, S.; Tatsuo Kobayashi

    1997-07-01

    We study Yukawa in string models with moduli-dominant SUSY breaking. This type of SUSY breaking in general leads to non-universal soft masses, i.e. soft scalar masses and gaugino masses. Such non-universality is important for phenomenological aspects of Yukawa unification, i.e., successful electroweak breaking, SUSY corrections to the bottom mass and the branching ratio of b → sγ. We show three regions in the whole parameter space which lead to successful electroweak breaking and allow small SUSY corrections to the bottom mass. For these three regions we investigated the b → sγ decay and mass spectra. (author). 26 refs, 6 figs

  18. The Significance of Peer-Editing in Teaching Writing to EFL Students

    Directory of Open Access Journals (Sweden)

    Zohreh Seifoori

    2008-05-01

    Full Text Available This study set out to investigate the effect of peer- editing as a metacognitive strategy on the development of writing. It was hypothesized that peer-editing could be used to raise grammatical and compositional awareness of the learners. Forty pre-intermediate sophomores at Islamic Azad University-Tabriz Branch participated in the study, taking the course Writing I. To warrant the initial homogeneity of the groups, a nonequivalent pretest –posttest design was selected and the groups were randomly determined as the control and the experimental groups, each with twenty subjects.  The treatment following the pretest involved a three-phase planning procedure including: consciousness awareness via error recognition activities, error categorizing activities, and self/peer editing. Statistical analysis of the post-test composition did not reveal any significant difference between the two groups.  It seems that peer-editing entails a firm grammatical foundation which needs to be formed early in the process of language learning. The results underscore the need to reorient the method of teaching grammar at university level in a way to accommodate a task-based approach to cognitive and metacognitive strategies-based training.

  19. Unification of Frequency direction Pilot-symbol Aided Channel Estimation (PACE) for OFDM

    DEFF Research Database (Denmark)

    Rom, Christian; Manchón, Carles Navarro; Deneire, Luc

    2007-01-01

    their specificities, namely the presence of virtual subcarriers and non-sample-spaced channels. To ease this choice, we propose a unified presentation of estimators encompassing most of the algorithms that can be found in literature, which only differ by the assumptions made on the channel. This unification leads...

  20. Bounds on the number of possible Higgs particles using grand unification and exceptional Lie groups

    International Nuclear Information System (INIS)

    El Naschie, M.S.

    2008-01-01

    The total sum of dimensions of a magnum exceptional Lie symmetry groups hierarchy is 4α-bar o =(4)(137+k o )≅548. Dividing this value among the various quantum fields leads to the possibility of an eight degrees of freedom Higgs field. However analyzing the same situation using sub groups of the largest exceptional Lie group leads to the conclusion that we are likely to find three Higgs particles only at the energy scale of the standard model. Consequently five of the eight degrees of freedom are unlikely to materialize as particles at this particular energy scale. This conclusion is reinforced by an entirely different approach based on grand unification analysis which excludes any grand unification using 4HD, i.e. four Higgs doublets. This leaves us with one, two and three Higgs doublets. Noting that a super symmetric standard model with two Higgs doublets gives almost perfect grand unification and that the result agrees with our exceptional Lie symmetry groups analysis, we exclude everything else. The final result is that we expect to find at least three more Higgs particles leading to a total of 66 elementary particles while at a somewhat higher energy, the expected number of 69 particles found using E-infinity theory is obtained

  1. Confronting the conventional ideas of grand unification with fermion masses, neutrino oscillations and proton decay

    Energy Technology Data Exchange (ETDEWEB)

    Pati, J C [Department of Physics, University of Maryland, College Park (United States) and Stanford Linear Accelerator Center, Menlo Park (United States)

    2002-09-15

    It is noted that one is now in possession of a set of facts, which may be viewed as the matching pieces of a puzzle; in that all of them can be resolved by just one idea - that is grand unification. These include: (i) the observed family-structure, (ii) quantization of electric charge, (iii) meeting of the three gauge couplings, (iv) neutrino oscillations; in particular the mass squared-difference {delta}m{sup 2}({nu}{sub {mu}} - {nu}{sub {tau}}) (suggested by SuperK), (v) the intricate pattern of the masses and mixings of the fermions, including the smallness of V{sub cb} and the largeness of {theta}{sub {nu}{sub {mu}{nu}}{sub {tau}}}{sup osc}, and (vi) the need for B-L as a generator to implement baryogenesis (via leptogenesis). All these pieces fit beautifully together within a single puzzle board framed by supersymmetric unification, based on SO(10) or a string-unified G(224)-symmetry. The two notable pieces of the puzzle still missing, however, are proton decay and supersymmetry. A concrete proposal is presented, within a predictive SO(10)/G(224)- framework, that successfully describes the masses and mixings of all fermions, including the neutrinos - with eight predictions, all in agreement with observation. Within this framework, a systematic study of proton decay is carried out, which (a) pays special attention to its dependence on the fermion masses, including the superheavy Majorana masses of the right-handed neutrinos, and (b) limits the threshold corrections so as to preserve natural coupling unification. The study updates prior work by Babu, Pati and Wilczek, in the context of both MSSM and its (interesting) variant, the so-called ESSM, by allowing for improved values of the matrix elements and of the short and long-distance renormalization effects. It shows that a conservative upper limit on the proton lifetime is about (1/3 - 2) x 10{sup 34} years, with {nu}-barK{sup +} being the dominant decay mode, and quite possibly {mu}{sup p}+K{sup 0} and e

  2. Confronting the conventional ideas of grand unification with fermion masses, neutrino oscillations and proton decay

    International Nuclear Information System (INIS)

    Pati, J.C.

    2002-01-01

    It is noted that one is now in possession of a set of facts, which may be viewed as the matching pieces of a puzzle; in that all of them can be resolved by just one idea - that is grand unification. These include: (i) the observed family-structure, (ii) quantization of electric charge, (iii) meeting of the three gauge couplings, (iv) neutrino oscillations; in particular the mass squared-difference Δm 2 (ν μ - ν τ ) (suggested by SuperK), (v) the intricate pattern of the masses and mixings of the fermions, including the smallness of V cb and the largeness of θ ν μ ν τ osc , and (vi) the need for B-L as a generator to implement baryogenesis (via leptogenesis). All these pieces fit beautifully together within a single puzzle board framed by supersymmetric unification, based on SO(10) or a string-unified G(224)-symmetry. The two notable pieces of the puzzle still missing, however, are proton decay and supersymmetry. A concrete proposal is presented, within a predictive SO(10)/G(224)- framework, that successfully describes the masses and mixings of all fermions, including the neutrinos - with eight predictions, all in agreement with observation. Within this framework, a systematic study of proton decay is carried out, which (a) pays special attention to its dependence on the fermion masses, including the superheavy Majorana masses of the right-handed neutrinos, and (b) limits the threshold corrections so as to preserve natural coupling unification. The study updates prior work by Babu, Pati and Wilczek, in the context of both MSSM and its (interesting) variant, the so-called ESSM, by allowing for improved values of the matrix elements and of the short and long-distance renormalization effects. It shows that a conservative upper limit on the proton lifetime is about (1/3 - 2) x 10 34 years, with ν-barK + being the dominant decay mode, and quite possibly μ p +K 0 and e + π 0 being prominent. This in turn strongly suggests that an improvement in the current

  3. Implications of results from the CERN e+e- collider LEP for SO(10) grand unification with two intermediate stages

    International Nuclear Information System (INIS)

    Deshpande, N.G.; Keith, E.; Pal, P.B.

    1993-01-01

    We consider the breaking of the grand unification group SO(10) to the standard model gauge group through several chains containing two intermediate stages. Using the values of the gauge coupling constants at a scale M Z derived from recent data from the CERN e + e- collider LEP, we determine the range of their intermediate and unification scales. In particular, we identify those chains that permit new gauge structure at relatively low energy (∼1 TeV)

  4. Prospects for mass unification at low energy scales

    International Nuclear Information System (INIS)

    Volkas, R.R.

    1995-01-01

    A simple Pati-Salam SU(4) model with a low symmetry breaking scale of about 1000 TeV is presented. The analysis concentrates on calculating radiative corrections to tree level mass relations for third generation fermions. The tree-level relation m b /m τ = 1 predicted by such models can receive large radiative corrections up to about 50% due to threshold effects at the mass unification scale. These corrections are thus of about the same importance as those that give rise to renormalisation group running. The high figure of 50% can be achieved because l-loop graphs involving the physical charged Higgs boson give corrections to m τ -m b that are proportional to the large top quark mass. These corrections can either increase or decrease m b /m τ depending on the value of an unknown parameter. They can also be made to vanish through a fine-tuning. A related model of tree-level t-b-τ unification which uses the identification of SU(2) R with custodial SU(2) is then discussed. A curious relation m b ∼ √2m τ is found to be satisfied at tree-level in this model. The overall conclusion of this work is that the tree-level relation m b =m τ at low scales such as 1000 TeV or somewhat higher can produce a successful value for m b /m τ after corrections, but one must be mindful that radiative corrections beyond those incorporated through the renormalisation group can be very important. 14 refs., 7 figs

  5. Qualitative Data Analysis: A Methods Sourcebook. Third Edition

    Science.gov (United States)

    Miles, Matthew B.; Huberman, A. Michael; Saldana, Johnny

    2014-01-01

    The Third Edition of Miles & Huberman's classic research methods text is updated and streamlined by Johnny Saldaña, author of "The Coding Manual for Qualitative Researchers." Several of the data display strategies from previous editions are now presented in re-envisioned and reorganized formats to enhance reader accessibility and…

  6. Full text clustering and relationship network analysis of biomedical publications.

    Directory of Open Access Journals (Sweden)

    Renchu Guan

    Full Text Available Rapid developments in the biomedical sciences have increased the demand for automatic clustering of biomedical publications. In contrast to current approaches to text clustering, which focus exclusively on the contents of abstracts, a novel method is proposed for clustering and analysis of complete biomedical article texts. To reduce dimensionality, Cosine Coefficient is used on a sub-space of only two vectors, instead of computing the Euclidean distance within the space of all vectors. Then a strategy and algorithm is introduced for Semi-supervised Affinity Propagation (SSAP to improve analysis efficiency, using biomedical journal names as an evaluation background. Experimental results show that by avoiding high-dimensional sparse matrix computations, SSAP outperforms conventional k-means methods and improves upon the standard Affinity Propagation algorithm. In constructing a directed relationship network and distribution matrix for the clustering results, it can be noted that overlaps in scope and interests among BioMed publications can be easily identified, providing a valuable analytical tool for editors, authors and readers.

  7. 76 FR 15209 - 150th Anniversary of the Unification of Italy, 2011

    Science.gov (United States)

    2011-03-21

    ... fighting for the preservation of our own Union, Giuseppe Garibaldi's campaign for the unification of Italy... millions of American women and men of Italian descent who strengthen and enrich our Nation. Italy and the... thousand eleven, and of the Independence of the United States of America the two hundred and thirty-fifth...

  8. OPTIMALISASI EDITING GREEN SCREEN MENGGUNAKAN TEKNIK LIGHTING PADA CHROMA KEY

    Directory of Open Access Journals (Sweden)

    Arin Yuli Astuti

    2016-10-01

    Full Text Available In the film world greenscreen or bluescreen is already widely in use as a background making technology . Utilization of this technology is very great because filmmakers can imagine changing the background to the shape or the desired atmosphere without having to perform image capture directly to the location . Chroma key is a technique for combining two images made with a video camera as well , in which a background color of an image to remove (made transparent , was replaced by another image behind it. Deficiencies that exist in the chroma key is that at the time of editing of the hair . Here the author tries to do research on how to minimize the weaknesses mengilangkan edge portion of hair at the time of editing green screen by optimizing lighting / lighting .

  9. THE UNIFICATION OF POWERFUL QUASARS AND RADIO GALAXIES AND THEIR RELATION TO OTHER MASSIVE GALAXIES

    Energy Technology Data Exchange (ETDEWEB)

    Podigachoski, Pece; Barthel, Peter [Kapteyn Astronomical Institute, University of Groningen, 9747 AD Groningen (Netherlands); Haas, Martin [Astronomisches Institut, Ruhr Universität, D-44801 Bochum (Germany); Leipski, Christian [Max-Planck Institut für Astronomie (MPIA), D-69117 Heidelberg (Germany); Wilkes, Belinda, E-mail: podigachoski@astro.rug.nl [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States)

    2015-06-10

    The unification model for powerful radio galaxies (RGs) and radio-loud quasars postulates that these objects are intrinsically the same but viewed along different angles. Herschel Space Observatory data permit the assessment of that model in the far-infrared spectral window. We analyze photometry from Spitzer and Herschel for the distant 3CR hosts, and find that RGs and quasars have different mid-infrared, but indistinguishable far-infrared colors. Both these properties, the former being orientation dependent and the latter orientation invariant, are in line with expectations from the unification model. Adding powerful radio-quiet active galaxies and typical massive star-forming (SF) galaxies to the analysis, we demonstrate that infrared colors not only provide an orientation indicator, but can also distinguish active from SF galaxies.

  10. THE UNIFICATION OF POWERFUL QUASARS AND RADIO GALAXIES AND THEIR RELATION TO OTHER MASSIVE GALAXIES

    International Nuclear Information System (INIS)

    Podigachoski, Pece; Barthel, Peter; Haas, Martin; Leipski, Christian; Wilkes, Belinda

    2015-01-01

    The unification model for powerful radio galaxies (RGs) and radio-loud quasars postulates that these objects are intrinsically the same but viewed along different angles. Herschel Space Observatory data permit the assessment of that model in the far-infrared spectral window. We analyze photometry from Spitzer and Herschel for the distant 3CR hosts, and find that RGs and quasars have different mid-infrared, but indistinguishable far-infrared colors. Both these properties, the former being orientation dependent and the latter orientation invariant, are in line with expectations from the unification model. Adding powerful radio-quiet active galaxies and typical massive star-forming (SF) galaxies to the analysis, we demonstrate that infrared colors not only provide an orientation indicator, but can also distinguish active from SF galaxies

  11. Performers, Composers, Scores and Editions: Commentary on Huisman, Gingras, Dhondt, and Leman (2017

    Directory of Open Access Journals (Sweden)

    Dorottya Fabian

    2017-09-01

    Full Text Available Reflecting on a study that examines the impact of various editions on the speed of learning and performance errors, this short paper notes the crudeness of western music notation and how musicians cope with deciphering the composer's musical intentions. Drawing on parallels with practitioners who specialize in historically informed performance and tend to favor playing from manuscripts and facsimiles, I argue that although performing editions are useful, proper education regarding the meaning of notation practices and compositional styles might better serve musicians. This enables each generation to construct its own understanding of the music, and of the contradictory and insufficiently specified demands of the score.

  12. A Comprehensive Toolbox for Genome Editing in Cultured Drosophila melanogaster Cells

    Directory of Open Access Journals (Sweden)

    Stefan Kunzelmann

    2016-06-01

    Full Text Available Custom genome editing has become an essential element of molecular biology. In particular, the generation of fusion constructs with epitope tags or fluorescent proteins at the genomic locus facilitates the analysis of protein expression, localization, and interaction partners at physiologic levels. Following up on our initial publication, we now describe a considerably simplified, more efficient, and readily scalable experimental workflow for PCR-based genome editing in cultured Drosophila melanogaster cells. Our analysis at the act5C locus suggests that PCR-based homology arms of 60 bp are sufficient to reach targeting efficiencies of up to 80% after selection; extension to 80 bp (PCR or 500 bp (targeting vector did not further improve the yield. We have expanded our targeting system to N-terminal epitope tags; this also allows the generation of cell populations with heterologous expression control of the tagged locus via the copper-inducible mtnDE promoter. We present detailed, quantitative data on editing efficiencies for several genomic loci that may serve as positive controls or benchmarks in other laboratories. While our first PCR-based editing approach offered only blasticidin-resistance for selection, we now introduce puromycin-resistance as a second, independent selection marker; it is thus possible to edit two loci (e.g., for coimmunoprecipitation without marker removal. Finally, we describe a modified FLP recombinase expression plasmid that improves the efficiency of marker cassette FLP-out. In summary, our technique and reagents enable a flexible, robust, and cloning-free genome editing approach that can be parallelized for scale-up.

  13. Unification venoplasty to cope with recipient portal vein anomaly during living donor liver transplantation.

    Science.gov (United States)

    Kang, S-H; Hwang, S; Jung, D-H; Ahn, C-S; Moon, D-B; Ha, T-Y; Song, G-W; Kim, K-H; Park, G-C; Namgoong, J-M; Park, Y-H; Park, H-W; Jung, B-H; Lee, S-G

    2013-10-01

    To cope with recipient portal vein (PV) anomalies, such as early branching of the right posterior section (RPS), during living donor liver transplantation (LDLT) surgery, we performed a simulation study to standardize the surgical technique for unification portal venoplasty. This study included an observational analysis of conventional methods utilizing RPS PV, simulation-based design of a new surgical technique, and clinical application of this new technique. In a case encountering RPS PV, a mild anastomotic PV stenosis was persistent over 6 months postsurgery, indicating the need for technical refinement. After computational simulation analysis, we found that simple suturing of the PV branch patch automatically resulted in a funnel-shaped elongation. A prospective recipient study (n = 30) indicated that usual PV reconstruction via the PV bifurcation method is feasible in the absence of unusual donor or recipient PV anomaly. Retrospective living donor PV anatomy analysis (n = 20) revealed that 20-mm-long limbs of the first-order PV branches are necessary to make a 10- to l5-mm-long funneled PV stump. This technique of unification venoplasty for an anomalous recipient PV was applied to an adult patient undergoing LDLT with a right liver graft, for which it was shown to be technically feasible and effective. A simplified unification venoplasty technique was developed to cope with a recipient PV anomaly in adult LDLT. Copyright © 2013. Published by Elsevier Inc.

  14. Language Editing at Astronomy & Astrophysics

    Science.gov (United States)

    Adams, J.

    2011-07-01

    In 2002, the A&A Board of Directors voted that all articles must be written in English and decided to improve the overall quality of the language in the articles with the help of a team of language editors. This article reviews the general advantages of editing the English expression and describes both the aims of this effort and its place in the full publication process. This is followed by the Guide to language editing that has been available on the Journal's website for several years now.

  15. Genome editing: Bioethics shows the way.

    Directory of Open Access Journals (Sweden)

    Carolyn P Neuhaus

    2017-03-01

    Full Text Available When some scientists hear the word "bioethics," they break out in intellectual hives. They shouldn't. Good bioethics is about enabling science to move forward. Bioethics pushes scientists to acknowledge that they operate not within a vacuum but within a society in which diverse perspectives and values must be engaged. Bioethicists give voice to those divergent perspectives and provide a framework to facilitate informed and inclusive discussions that spur progress, rather than stall it. The field is needed to advance cutting-edge biomedical research in domains in which the benefits to be had are enormous, such as genome editing, but ethical concerns persist.

  16. Group theory approach to unification of gravity with internal symmetry gauge interactions. Part 1

    International Nuclear Information System (INIS)

    Samokhvalov, S.E.; Vanyashin, V.S.

    1990-12-01

    The infinite group of deformed diffeomorphisms of space-time continuum is put into the basis of the Gauge Theory of Gravity. This gives rise to some new ways for unification of gravity with other gauge interactions. (author). 7 refs

  17. Automatically classifying sentences in full-text biomedical articles into Introduction, Methods, Results and Discussion.

    Science.gov (United States)

    Agarwal, Shashank; Yu, Hong

    2009-12-01

    Biomedical texts can be typically represented by four rhetorical categories: Introduction, Methods, Results and Discussion (IMRAD). Classifying sentences into these categories can benefit many other text-mining tasks. Although many studies have applied different approaches for automatically classifying sentences in MEDLINE abstracts into the IMRAD categories, few have explored the classification of sentences that appear in full-text biomedical articles. We first evaluated whether sentences in full-text biomedical articles could be reliably annotated into the IMRAD format and then explored different approaches for automatically classifying these sentences into the IMRAD categories. Our results show an overall annotation agreement of 82.14% with a Kappa score of 0.756. The best classification system is a multinomial naïve Bayes classifier trained on manually annotated data that achieved 91.95% accuracy and an average F-score of 91.55%, which is significantly higher than baseline systems. A web version of this system is available online at-http://wood.ims.uwm.edu/full_text_classifier/.

  18. Pervasive Genotypic Mosaicism in Founder Mice Derived from Genome Editing through Pronuclear Injection.

    Directory of Open Access Journals (Sweden)

    Daniel Oliver

    Full Text Available Genome editing technologies, especially the Cas9/CRISPR system, have revolutionized biomedical research over the past several years. Generation of novel alleles has been simplified to unprecedented levels, allowing for rapid expansion of available genetic tool kits for researchers. However, the issue of genotypic mosaicism has become evident, making stringent analyses of the penetrance of genome-edited alleles essential. Here, we report that founder mice, derived from pronuclear injection of ZFNs or a mix of guidance RNAs and Cas9 mRNAs, display consistent genotypic mosaicism for both deletion and insertion alleles. To identify founders with greater possibility of transmitting the mutant allele through the germline, we developed an effective germline genotyping method. The awareness of the inherent genotypic mosaicism issue with genome editing will allow for a more efficient implementation of the technologies, and the germline genotyping method will save valuable time and resources.

  19. With this Special Edition

    Directory of Open Access Journals (Sweden)

    Oscar Antonio Martínez Molina

    2017-02-01

    Full Text Available With this Special Edition, the refereed Scientific Magazine, published in February 2017, presents a nourished and multidisciplinary theme, from the relationship of Environmental Education, in this ecological sharing man-environment; the social responsibility from the Management environment and the motivational values ​​conducive to the teaching performance in the different educational levels. Twenty-five (25 articles, generated from research production in university environments at the International level, are a signature of the quality of articles / essays presented in this Special Edition. Several reasons motivate the literary pen of our authors, adjusting to the rhythm of the times and the use of new technologies; and in correspondence with the care of the environment, this way of disseminating and making visible the scientific contents of humanistic and social court, support the care and protection of the forests, being an online production, in the Cloud. Thanks to the support of the Instituto Internacional de Investigación y Desarrollo Tecnológico Educativo INDTEC, CA, Scientific Magazine has been able to develop from the cooperative work of the people who compose its different committees: Editorial Academic Committee, Academic Scientific Committee and the Arbitrators in the review and valuation of the quality of the articles. With these assets, the Scientific Magazine, opening to the general public and especially to the academic new intellectual horizons.

  20. Full-text publication of abstract-presented work in physical therapy: do therapists publish what they preach?

    Science.gov (United States)

    Smith, Heather D; Bogenschutz, Elizabeth D; Bayliss, Amy J; Altenburger, Peter A; Warden, Stuart J

    2011-02-01

    Professional meetings, such as the American Physical Therapy Association's (APTA's) Combined Sections Meeting (CSM), provide forums for sharing information relevant to physical therapy. An indicator of whether therapists fully disseminate their work is the number of full-text peer-reviewed publications that result. The purposes of this study were: (1) to determine the full-text publication rate of work presented in abstract form at CSM and (2) to investigate factors influencing this rate. A systematic search was undertaken to locate full-text publications of work presented in abstract form within the Orthopaedic and Sports Physical Therapy sections at CSM between 2000 and 2004. Eligible publications were published within 5 years following abstract presentation. The influences of APTA section, year of abstract presentation, institution of origin, study design, sample size, study significance, reporting of a funding source, and presentation type on full-text publication rate were assessed. Characteristics of full-text publications were explored. Work presented in 1 out of 4 abstracts (25.4%) progressed to full-text publication. Odds of full-text publication increased if the abstract originated from a doctorate-granting or "other" institution, reported findings of an experimental study, reported a statistically significant finding, included a larger sample size, disclosed a funding source, or was presented as a platform presentation. More than one third (37.8%) of full-text publications were published in the Journal of Orthopaedic and Sports Physical Therapy or Physical Therapy, and 4 out of 10 full-text publications (39.2%) contained at least one major change from information presented in abstract form. The full-text publication rate for information presented in abstract form within the Orthopaedic and Sports Physical Therapy sections at CSM is low relative to comparative disciplines. Caution should be exercised when translating information presented at CSM into

  1. Canonical A-to-I and C-to-U RNA editing is enriched at 3'UTRs and microRNA target sites in multiple mouse tissues.

    Directory of Open Access Journals (Sweden)

    Tongjun Gu

    Full Text Available RNA editing is a process that modifies RNA nucleotides and changes the efficiency and fidelity of the central dogma. Enzymes that catalyze RNA editing are required for life, and defects in RNA editing are associated with many diseases. Recent advances in sequencing have enabled the genome-wide identification of RNA editing sites in mammalian transcriptomes. Here, we demonstrate that canonical RNA editing (A-to-I and C-to-U occurs in liver, white adipose, and bone tissues of the laboratory mouse, and we show that apparent non-canonical editing (all other possible base substitutions is an artifact of current high-throughput sequencing technology. Further, we report that high-confidence canonical RNA editing sites can cause non-synonymous amino acid changes and are significantly enriched in 3' UTRs, specifically at microRNA target sites, suggesting both regulatory and functional consequences for RNA editing.

  2. Abundant off-target edits from site-directed RNA editing can be reduced by nuclear localization of the editing enzyme.

    Science.gov (United States)

    Vallecillo-Viejo, Isabel C; Liscovitch-Brauer, Noa; Montiel-Gonzalez, Maria Fernanda; Eisenberg, Eli; Rosenthal, Joshua J C

    2018-01-02

    Site-directed RNA editing (SDRE) is a general strategy for making targeted base changes in RNA molecules. Although the approach is relatively new, several groups, including our own, have been working on its development. The basic strategy has been to couple the catalytic domain of an adenosine (A) to inosine (I) RNA editing enzyme to a guide RNA that is used for targeting. Although highly efficient on-target editing has been reported, off-target events have not been rigorously quantified. In this report we target premature termination codons (PTCs) in messages encoding both a fluorescent reporter protein and the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein transiently transfected into human epithelial cells. We demonstrate that while on-target editing is efficient, off-target editing is extensive, both within the targeted message and across the entire transcriptome of the transfected cells. By redirecting the editing enzymes from the cytoplasm to the nucleus, off-target editing is reduced without compromising the on-target editing efficiency. The addition of the E488Q mutation to the editing enzymes, a common strategy for increasing on-target editing efficiency, causes a tremendous increase in off-target editing. These results underscore the need to reduce promiscuity in current approaches to SDRE.

  3. INTRODUCTION A L'UNIFICATION DES INTERACTIONS ELECTROMAGNETIQUES ET FAIBLES

    OpenAIRE

    Martin , F.

    1980-01-01

    Après avoir décrit l'état actuel de la phénoménologie des interactions faibles on discute les principes de base des théories de jauge. On montre ensuite comment le mécanisme de Higgs permet d'obtenir des quanta d'interaction massifs. Le modèle dit de "Weinberg-Salam" permettant d'unifier les interactions électromagnétiques et faibles est présenté. On termine par quelques mots sur l'unification avec les interactions fortes et la gravitation.

  4. Strings: A possible alternative explanation for the Unification of Gravitation Field and Electromagnetic Field

    Science.gov (United States)

    Rivera, Susana

    Throughout the last century, since the last decades of the XIX century, until present day, there had been many attempts to achieve the unification of the Forces of Nature. First unification was done by James Clerk Maxwell, with his Electromagnetic Theory. Then Max Plank developed his Quantum Theory. In 1905, Albert Einstein gave birth to the Special Relativity Theory, and in 1916 he came out with his General Relativity Theory. He noticed that there was an evident parallelism between the Gravitational Force, and the Electromagnetic Force. So, he tried to unify these forces of Nature. But Quantum Theory interposed on his way. On the 1940’s it had been developed the Quantum Electrodynamics (QED), and with it, the unified field theory had an arise interest. On the 60’s and 70’s there was developed the Quantum Chromodynamics (QCD). Along with these theories came the discovery of the strong interaction force and weak interaction force. And though there had been many attempts to unify all these forces of the nature, it could only be achieved the Unification of strong interaction, weak interaction and Electromagnetic Force. On the late 80”s and throughout the last two decades, theories such as “super-string theory”, “or the “M-theory”, among others, groups of Scientists, had been doing grand efforts and finally they came out with the unification of the forces of nature, being the only limitation the use of more than 11 dimensions. Using an ingenious mathematical tool known as the super symmetries, based on the Kaluza - Klein work, they achieve this goal. The strings of these theories are in the rank of 10-33 m. Which make them undetectable. There are many other string theories. The GEUFT theory is based on the existence of concentrated energy lines, which vibrates, expands and contracts, submitting and absorbing energy, matter and antimatter, and which yields a determined geometry, that gives as a result the formation of stars, galaxies, nebulae, clusters

  5. Prospects for mass unification at low energy scales

    Energy Technology Data Exchange (ETDEWEB)

    Volkas, R.R.

    1995-12-31

    A simple Pati-Salam SU(4) model with a low symmetry breaking scale of about 1000 TeV is presented. The analysis concentrates on calculating radiative corrections to tree level mass relations for third generation fermions. The tree-level relation m{sub b}/m{sub {tau}} = 1 predicted by such models can receive large radiative corrections up to about 50% due to threshold effects at the mass unification scale. These corrections are thus of about the same importance as those that give rise to renormalisation group running. The high figure of 50% can be achieved because l-loop graphs involving the physical charged Higgs boson give corrections to m{sub {tau}} -m{sub b} that are proportional to the large top quark mass. These corrections can either increase or decrease m{sub b}/m{sub {tau}} depending on the value of an unknown parameter. They can also be made to vanish through a fine-tuning. A related model of tree-level t-b-{tau} unification which uses the identification of SU(2){sub R} with custodial SU(2) is then discussed. A curious relation m{sub b}{approx} {radical}2m{sub {tau}} is found to be satisfied at tree-level in this model. The overall conclusion of this work is that the tree-level relation m{sub b}=m{sub {tau}} at low scales such as 1000 TeV or somewhat higher can produce a successful value for m{sub b}/m{sub {tau}} after corrections, but one must be mindful that radiative corrections beyond those incorporated through the renormalisation group can be very important. 14 refs., 7 figs.

  6. Depfix, a Tool for Automatic Rule-based Post-editing of SMT

    Directory of Open Access Journals (Sweden)

    Rudolf Rosa

    2014-09-01

    Full Text Available We present Depfix, an open-source system for automatic post-editing of phrase-based machine translation outputs. Depfix employs a range of natural language processing tools to obtain analyses of the input sentences, and uses a set of rules to correct common or serious errors in machine translation outputs. Depfix is currently implemented only for English-to-Czech translation direction, but extending it to other languages is planned.

  7. Induced Pluripotency and Gene Editing in Disease Modelling: Perspectives and Challenges

    Directory of Open Access Journals (Sweden)

    Yu Fen Samantha Seah

    2015-12-01

    Full Text Available Embryonic stem cells (ESCs are chiefly characterized by their ability to self-renew and to differentiate into any cell type derived from the three main germ layers. It was demonstrated that somatic cells could be reprogrammed to form induced pluripotent stem cells (iPSCs via various strategies. Gene editing is a technique that can be used to make targeted changes in the genome, and the efficiency of this process has been significantly enhanced by recent advancements. The use of engineered endonucleases, such as homing endonucleases, zinc finger nucleases (ZFNs, transcription activator-like effector nucleases (TALENs and Cas9 of the CRISPR system, has significantly enhanced the efficiency of gene editing. The combination of somatic cell reprogramming with gene editing enables us to model human diseases in vitro, in a manner considered superior to animal disease models. In this review, we discuss the various strategies of reprogramming and gene targeting with an emphasis on the current advancements and challenges of using these techniques to model human diseases.

  8. The semiotic construction of masculinity and affect: A multimodal analysis of media texts

    Directory of Open Access Journals (Sweden)

    Sônia Maria de Oliveira Pimenta

    2013-07-01

    Full Text Available http://dx.doi.org/10.5007/2175-8026.2013n64p173 The aim of this paper is to observe changes in the semiotic construction of masculine identities as a dynamic flux of social representations mediated by the multimodal aspect of texts (sensory modality, salience, behaviour and point of view.  The study compares previous research data from a magazine article of 2003 and its cover- page to four adverts of the 2005 edition and three recent adverts published in the 2008 edition of the same magazine, so as to perceive how they position readers ideologically in order to (1 detect how masculinity is discursively represented in its heterogeneity connected, ideologically, with power relations, vanity and emotions and (2 define their identities as consumers of goods and services.

  9. The Digital Editions of Revista Estudos Feministas (and the Democratization of the Access to the Scientific and Scademic Production

    Directory of Open Access Journals (Sweden)

    Sônia Weidner Maluf

    2008-01-01

    Full Text Available In this article we describe the electronic editions of Revista Estudos Feministas and our contribution towards a politics of democratization of the access to scientific and academic production. After a brief description of the three spaces of electronic editions of REF (the Electronic Library Scielo, the Scielo Social Science Portal and the Feminist Portal, we discuss the contribution of gender and feminist studies for the democratization of the access to the scientific and academic production.

  10. Unification of SUSY breaking and GUT breaking

    Energy Technology Data Exchange (ETDEWEB)

    Kobayashi, Tatsuo [Department of Physics, Hokkaido University,Sapporo 060-0810 (Japan); Omura, Yuji [Department of Physics, Nagoya University,Nagoya 464-8602 (Japan)

    2015-02-18

    We build explicit supersymmetric unification models where grand unified gauge symmetry breaking and supersymmetry (SUSY) breaking are caused by the same sector. Besides, the SM-charged particles are also predicted by the symmetry breaking sector, and they give the soft SUSY breaking terms through the so-called gauge mediation. We investigate the mass spectrums in an explicit model with SU(5) and additional gauge groups, and discuss its phenomenological aspects. Especially, nonzero A-term and B-term are generated at one-loop level according to the mediation via the vector superfields, so that the electro-weak symmetry breaking and 125 GeV Higgs mass may be achieved by the large B-term and A-term even if the stop mass is around 1 TeV.

  11. Palliative care for people with cancer (3rd edition) Jenny Penson Palliative care for people with cancer (3rd edition) Ronald Fisher (editors) Arnold 427pp £18.99 0340763965 0340763965 [Formula: see text].

    Science.gov (United States)

    2003-02-01

    This has been a successful textbook since publication of its first edition 11 years ago. This updated edition remains a useful resource for newcomers to palliative care in relation to cancer for nurses and other health professionals.

  12. On the further development of the electronic edition «NANOTECHNOLOGIES IN CONSTRUCTION: A Scientific Internet-Journal» in 2015

    Directory of Open Access Journals (Sweden)

    GUSEV Boris Vladimirovich

    2015-12-01

    Full Text Available In 2015 the electronic edition «NANOTECHNOLOGIES IN CONSTRUCTION: A Scientific Internet-Journal» achieved a great success, it is recognized not only by Russian scientists but also foreign ones: • the geography of the edition’s authors has been enlarged, the new sections and columns have been introduced; • the edition has been included in the following citation systems (data bases: Global Impact Factor (Australia, EZB (Germany, ResearchGate (USA, DOAJ (Sweden; • the edition has been included in the list of peer-review journals in which the candidates for Ph.D. and Doctorate degree must publish the main results of their theses; • the edition provided information support for the largest events in the area of construction and nanoindustry (BATIMAT, IV International congress of the nanoindustrial enterprises, SIBBUILD et al..

  13. Grand Unification as a Bridge Between String Theory and Phenomenology

    Energy Technology Data Exchange (ETDEWEB)

    Pati, Jogesh C.

    2006-06-09

    In the first part of the talk, I explain what empirical evidence points to the need for having an effective grand unification-like symmetry possessing the symmetry SU(4)-color in 4D. If one assumes the premises of a future predictive theory including gravity--be it string/M theory or a reincarnation--this evidence then suggests that such a theory should lead to an effective grand unification-like symmetry as above in 4D, near the string-GUT-scale, rather than the standard model symmetry. Advantages of an effective supersymmetric G(224) = SU(2){sub L} x SU(2){sub R} x SU(4){sup c} or SO(10) symmetry in 4D in explaining (1) observed neutrino oscillations, (2) baryogenesis via leptogenesis, and (3) certain fermion mass-relations are noted. And certain distinguishing tests of a SUSY G(224) or SO(10)-framework involving CP and flavor violations (as in {mu} {yields} e{gamma}, {tau} {yields} {mu}{gamma}, edm's of the neutron and the electron) as well as proton decay are briefly mentioned. Recalling some of the successes we have had in our understanding of nature so far, and the current difficulties of string/M theory as regards the large multiplicity of string vacua, some comments are made on the traditional goal of understanding vis a vis the recently evolved view of landscape and anthropism.

  14. Grand Unification as a Bridge Between String Theory and Phenomenology

    Science.gov (United States)

    Pati, Jogesh C.

    In the first part of this paper, we explain what empirical evidence points to the need for having an effective grand unification-like symmetry possessing the symmetry SU(4)-color in 4D. If one assumes the premises of a future predictive theory including gravity — be it string/M-theory or a reincarnation — this evidence then suggests that such a theory should lead to an effective grand unification-like symmetry as above in 4D, near the string-GUT-scale, rather than the standard model symmetry. Advantages of an effective supersymmetric G(224) = SU(2)L × SU(2)R × SU(4)c or SO(10) symmetry in 4D in explaining (i) observed neutrino oscillations, (ii) baryogenesis via leptogenesis, and (iii) certain fermion mass-relations are noted. And certain distinguishing tests of a SUSY G(224) or SO(10)-framework involving CP and flavor violations (as in μ → eγ, τ → μγ, edm's of the neutron and the electron) as well as proton decay are briefly mentioned. Recalling some of the successes we have had in our understanding of nature so far, and the current difficulties of string/M-theory as regards the large multiplicity of string vacua, some comments are made on the traditional goal of understanding vis a vis the recently evolved view of landscape and anthropism.

  15. Grand Unification as a Bridge Between String Theory and Phenomenology

    International Nuclear Information System (INIS)

    Pati, J

    2006-01-01

    In the first part of the talk, I explain what empirical evidence points to the need for having an effective grand unification-like symmetry possessing the symmetry SU(4)-color in 4D. If one assumes the premises of a future predictive theory including gravity--be it string/M theory or a reincarnation--this evidence then suggests that such a theory should lead to an effective grand unification-like symmetry as above in 4D, near the string-GUT-scale, rather than the standard model symmetry. Advantages of an effective supersymmetric G(224) = SU(2) L x SU(2) R x SU(4) c or SO(10) symmetry in 4D in explaining (1) observed neutrino oscillations, (2) baryogenesis via leptogenesis, and (3) certain fermion mass-relations are noted. And certain distinguishing tests of a SUSY G(224) or SO(10)-framework involving CP and flavor violations (as in μ → eγ, τ → μγ, edm's of the neutron and the electron) as well as proton decay are briefly mentioned. Recalling some of the successes we have had in our understanding of nature so far, and the current difficulties of string/M theory as regards the large multiplicity of string vacua, some comments are made on the traditional goal of understanding vis a vis the recently evolved view of landscape and anthropism

  16. Preparing College Students To Search Full-Text Databases: Is Instruction Necessary?

    Science.gov (United States)

    Riley, Cheryl; Wales, Barbara

    Full-text databases allow Central Missouri State University's clients to access some of the serials that libraries have had to cancel due to escalating subscription costs; EbscoHost, the subject of this study, is one such database. The database is available free to all Missouri residents. A survey was designed consisting of 21 questions intended…

  17. Full-text publication of abstracts in emergency medicine in Denmark

    DEFF Research Database (Denmark)

    Ravn, Anne Katrine; Petersen, Dan Brun; Folkestad, Lars

    2014-01-01

    INTRODUCTION: Abstracts presented at medical conferences or scientific meetings should ideally be published as full-text articles in peer-reviewed journals after initial presentation and feedback regardless of the findings. The aim of this survey was to determine the publication rate of papers...... similar publication rates. However, other more established specialties have higher publication levels. Knowledge of reasons for non-publication could lead to efforts to promote publication like funding; the possibility of discussion between authors and editors at conferences; "publication mentors"; and...

  18. Language Adaptation for Extending Post-Editing Estimates for Closely Related Languages

    Directory of Open Access Journals (Sweden)

    Rios Miguel

    2016-10-01

    Full Text Available This paper presents an open-source toolkit for predicting human post-editing efforts for closely related languages. At the moment, training resources for the Quality Estimation task are available for very few language directions and domains. Available resources can be expanded on the assumption that MT errors and the amount of post-editing required to correct them are comparable across related languages, even if the feature frequencies differ. In this paper we report a toolkit for achieving language adaptation, which is based on learning new feature representation using transfer learning methods. In particular, we report performance of a method based on Self-Taught Learning which adapts the English-Spanish pair to produce Quality Estimation models for translation from English into Portuguese, Italian and other Romance languages using the publicly available Autodesk dataset.

  19. Differential Binding of Mitochondrial Transcripts by MRB8170 and MRB4160 Regulates Distinct Editing Fates of Mitochondrial mRNA in Trypanosomes

    Directory of Open Access Journals (Sweden)

    Sameer Dixit

    2017-01-01

    Full Text Available A dozen mRNAs are edited by multiple insertions and/or deletions of uridine residues in the mitochondrion of Trypanosoma brucei. Several protein complexes have been implicated in performing this type of RNA editing, including the mitochondrial RNA-binding complex 1 (MRB1. Two paralogous novel RNA-binding proteins, MRB8170 and MRB4160, are loosely associated with the core MRB1 complex. Their roles in RNA editing and effects on target mRNAs are so far not well understood. In this study, individual-nucleotide-resolution UV-cross-linking and affinity purification (iCLAP revealed a preferential binding of both proteins to mitochondrial mRNAs, which was positively correlated with their extent of editing. Integrating additional in vivo and in vitro data, we propose that binding of MRB8170 and/or MRB4160 onto pre-mRNA marks it for the initiation of editing and that initial binding of both proteins may facilitate the recruitment of other components of the RNA editing/processing machinery to ensure efficient editing. Surprisingly, MRB8170 also binds never-edited mRNAs, suggesting that at least this paralog has an additional role outside RNA editing to shape the mitochondrial transcriptome.

  20. Targeted Editing of Myostatin Gene in Sheep by Transcription Activator-like Effector Nucleases

    Directory of Open Access Journals (Sweden)

    Xinxia Zhao

    2016-03-01

    Full Text Available Myostatin (MSTN is a secreted growth factor expressed in skeletal muscle and adipose tissue that negatively regulates skeletal muscle mass. Gene knockout of MSTN can result in increasing muscle mass in sheep. The objectives were to investigate whether myostatin gene can be edited in sheep by transcription activator-like effector nucleases (TALENs in tandem with single-stranded DNA oligonucleotides (ssODNs. We designed a pair of TALENs to target a highly conserved sequence in the coding region of the sheep MSTN gene. The activity of the TALENs was verified by using luciferase single-strand annealing reporter assay in HEK 293T cell line. Co-transfection of TALENs and ssODNs oligonucleotides induced precise gene editing of myostatin gene in sheep primary fibroblasts. MSTN gene-edited cells were successfully used as nuclear donors for generating cloned embryos. TALENs combined with ssDNA oligonucleotides provide a useful approach for precise gene modification in livestock animals.

  1. Building a Larger Tent for Public Health: Implications of the SOPHE-AAHE Unification

    Science.gov (United States)

    Goodman, Robert Mark

    2013-01-01

    The unification of the American Association for Health Education (AAHE) and the Society for Public Health Education (SOPHE) generates a long-desired synergy, a ramping up of our leadership influence in promoting health. It also serves as an ongoing opportunity to reflect on how we synergize the distinct philosophic, scientific, and practical…

  2. Residential and Light Commercial HVAC. Teacher Edition and Student Edition. Second Edition.

    Science.gov (United States)

    Stephenson, David

    This package contains teacher and student editions of a residential and light commercial heating, ventilation, and air conditioning (HVAC) course of study. The teacher edition contains information on the following: using the publication; national competencies; competency profile; related academic and workplace skills list; tools, equipment, and…

  3. Wikipedia Edit-a-thons: Thinking Beyond the Warm Fuzzies

    Directory of Open Access Journals (Sweden)

    Danielle Robichaud

    2017-02-01

    Full Text Available Wikipedia edit-a-thons represent a unique and fruitful avenue for galleries, libraries, archives and museums (GLAMs to engage with new and existing segments of their user communities. Encompassing information and technical literacy skills development, the success of edit-a-thon campaigns, such the annual art+feminism events, demonstrate their utility and value as outreach initiatives. What is less clear are the logistical, ethical and professional development implications of hosting these events. Centering first-hand experience and concrete examples, this paper explores GLAM-based edit-a-thons through a practical and actionable lens. Topics covered include: what is required to successfully host an edit-a-thon; the importance of leading by example in a volunteer-reliant economy; and the transferable work skills gained by hosting and participating in edit-a-thons. Des « édit-a-thons » (marathon d’édition de texte sur Wikipédia offrent aux galeries, bibliothèques, archives et musées une façon unique et efficace d’interagir avec de nouveaux ou d’existants segments de leur communauté. En incorporant le développement de compétences techniques et informationnelles, le succès des édit-a-thons, tel que l’événement annuel art+feminism, démontre leur utilité et leur valeur comme initiative de sensibilisation. Toutefois, les implications liées à la logistique, l’éthique et au développement professionnel en tant qu’hôte de tels événements demeurent ambiguës. En s’inspirant d’une expérience unique et d’exemples concrets, cet article utilise une approche pratique et appliquée pour explorer des édit-a-thons au sein des galeries, bibliothèques, archives et musées. Les sujets abordés comprennent les éléments requis pour que les édit-a-thons connaissent un succès, l’importance d’être un exemple à suivre au sein d’une économie basée sur des bénévoles et les habiletés transférables acquises en

  4. Gauge coupling running in minimal SU(3) x SU(2) x U(1) superstring unification

    CERN Document Server

    Ibáñez, L E; Ross, Graham G

    1991-01-01

    We study the evolution of the gauge coupling constants in string unification schemes in which the light spectrum below the compactification scale is exactly that of the minimal supersymmetric standard model. In the absence of string threshold corrections the predicted values $\\sin^2\\theta _W=0.218$ and $\\alpha _s=0.20$ are in gross conflict with experiment, but these corrections are generically important. One can express the string threshold corrections to $\\sin^2\\theta _W$ and $\\alpha_s$ in terms of certain $modular$ $weights$ of quark, lepton and Higgs superfields as well as the $moduli$ of the string model. We find that in order to get agreement with the experimental measurements within the context of this $minimal$ scheme, certain constraints on the $modular$ $weights$ of the quark, lepton and Higgs superfields should be obeyed. Our analysis indicates that this $minimal$ $string$ $unification$

  5. Fandom unbound: Otaku culture in a connected world, edited by Mizuko Ito, Daisuke Okabe, and Izumi Tsuji [book review

    Directory of Open Access Journals (Sweden)

    Nele Noppe

    2015-03-01

    Full Text Available Review of Mizuko Ito, Daisuke Okabe and Izumi Tsuji, eds. Fandom unbound: Otaku culture in a connected world. New Haven, CT: Yale University Press, 2012, Kindle edition, $35; paperback, $38 (352p ISBN 978-0300158649.

  6. Korean Unification and the Future of the U.S.-ROK Alliance

    Science.gov (United States)

    2016-02-01

    including the Korean People’s Army, which, by ROK estimates, numbers 1.2 million in the active force and some 7.7 million in the reserve , or...management. A broader alli- ance agenda would also place a premium on establishing an interagency or whole-of-government dialogue, fusing together...annualized gross domestic product (GDP). See Christine Kim, “Korean Unification May Cost South 7 Percent of GDP: Ministry,” Reuters, January 1, 2013

  7. Intelligent System for Data Tracking in Image Editing Company

    Directory of Open Access Journals (Sweden)

    Kimlong Ngin

    2017-11-01

    Full Text Available The success of data transaction in a company largely depends on the intelligence system used in its database and application system. The complex and heterogeneous data in the log file make it more difficult for users to manage data effectively. Therefore, this paper creates an application system that can manage data from the log file. A sample was collected from an image editing company in Cambodia by interviewing five customers and seven operators, who worked on the data files for 300 images. This paper found two results: first, the agent script was used for retrieving data from the log file, classifying data, and inserting data into a database; and second, the web interface was used for the viewing of results by the users. The intelligence capabilities of our application, together with a friendly web-based and window-based experience, allow the users to easily acquire, manage, and access the data in an image editing company.

  8. Bindings and covers of Cyrillic old printed editions of Holy Dormition Pochayiv Lavra publishing house

    Directory of Open Access Journals (Sweden)

    Zheleznyak O.

    2014-01-01

    Full Text Available The article observes bindings and covers of Holy Dormition Pochayiv monastery publishing house editions. On the basis of copies from V. Vernadsky National Library of Ukraine fonds the covering material and decoration (centerpieces, ornaments, corner pieces of Pochayiv editions covers are analyzed. Besides that, distinctive features of Pochaiv publishing house bindings and covers are defined and described. Description of bindings enabled us to find bookbinder’s chiches, which had often been put on bottom endleafs. Special attention in the article is paid to highly artistic decoration of Pochayiv publishing house bindings of Altar Gospels. In the eighties of 18th century Pochayiv publishing house printed books, ordered by Old Believers. As a rule Old Believers editions derive all their compositional elements from books of 17th century, published before the reform. Bindings of Pochayiv Old Believers editions, distinctive for its modest decoration, are not exception of this rule. Besides that, Pochayiv old printed books were sometimes binded in covers made by Kyiv Pechersk Lavra craftsmen. Centerpieces of these covers sometimes contain the image of Kyiv Holy Dormition cathedral.

  9. Hierarchy of symmetry-breaking scales in SO(10) grand unification and particle masses

    International Nuclear Information System (INIS)

    Asatryan, G.M.; Ioannisyan, A.N.

    1987-01-01

    An SO(10) grand unification model is proposed in which the introduction of an additional discrete symmetry solves the problem of the quark mass spectrum arising in SO(10) breaking schemes with intermediate SU(4) x SU(2)/sub L/ x SU(2)/sub R/ or SU(3)/sub C/ x U(1)/sub B//sub -//sub L/ x SU(2)/sub L/ x SU(2)/sub R/ symmetry. When the breaking of this discrete symmetry is taken into account the condition that there exist only a single light Higgs boson leads to a relation between the b- and t-quark masses which makes it possible to fix the ratio of the grand unification scale M/sub X/ and the quark--lepton symmetry-breaking scale M/sub C/. The specific values of M/sub X/ and M/sub C/ and also the scale of the SU(2)/sub R/ symmetry breaking M/sub R/ depend on the experimental value of the Weinberg angle and are in agreement with the experimental data on proton decay

  10. Technicolor and Beyond: Unification in Theory Space

    DEFF Research Database (Denmark)

    Sannino, Francesco

    2010-01-01

    The salient features of models of dynamical electroweak symmetry breaking are reviewed. The ideal walking idea is introduced according to which one should carefully take into account the effects of the extended technicolor dynamics on the technicolor dynamics itself. The effects amount at the enh......The salient features of models of dynamical electroweak symmetry breaking are reviewed. The ideal walking idea is introduced according to which one should carefully take into account the effects of the extended technicolor dynamics on the technicolor dynamics itself. The effects amount...... supersymmetry and technicolor. The reason is to provide a unification of different extensions of the standard model. For example, this means that one can recover, according to the parameters and spectrum of the theory distinct extensions of the standard model, from supersymmetry to technicolor and unparticle...

  11. Nontrivial asymptotically nonfree gauge theories and dynamical unification of couplings

    International Nuclear Information System (INIS)

    Kubo, J.

    1995-01-01

    Evidence for the nontriviality of asymptotically nonfree (ANF) Yang-Mills theories is found on the basis of optimized perturbation theory. It is argued that these theories with matter couplings can be made nontrivial by means of the reduction of couplings, leading to the idea of the dynamical unification of couplings (DUC). The second-order reduction of couplings in the ANF SU(3)-gauged Higgs-Yukawa theory, which is assumed to be nontrivial here, is carried out to motivate independent investigations on its nontriviality and DUC

  12. Reported estimates of diagnostic accuracy in ophthalmology conference abstracts were not associated with full-text publication.

    Science.gov (United States)

    Korevaar, Daniël A; Cohen, Jérémie F; Spijker, René; Saldanha, Ian J; Dickersin, Kay; Virgili, Gianni; Hooft, Lotty; Bossuyt, Patrick M M

    2016-11-01

    To assess whether conference abstracts that report higher estimates of diagnostic accuracy are more likely to reach full-text publication in a peer-reviewed journal. We identified abstracts describing diagnostic accuracy studies, presented between 2007 and 2010 at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting. We extracted reported estimates of sensitivity, specificity, area under the receiver operating characteristic curve (AUC), and diagnostic odds ratio (DOR). Between May and July 2015, we searched MEDLINE and EMBASE to identify corresponding full-text publications; if needed, we contacted abstract authors. Cox regression was performed to estimate associations with full-text publication, where sensitivity, specificity, and AUC were logit transformed, and DOR was log transformed. A full-text publication was found for 226/399 (57%) included abstracts. There was no association between reported estimates of sensitivity and full-text publication (hazard ratio [HR] 1.09 [95% confidence interval {CI} 0.98, 1.22]). The same applied to specificity (HR 1.00 [95% CI 0.88, 1.14]), AUC (HR 0.91 [95% CI 0.75, 1.09]), and DOR (HR 1.01 [95% CI 0.94, 1.09]). Almost half of the ARVO conference abstracts describing diagnostic accuracy studies did not reach full-text publication. Studies in abstracts that mentioned higher accuracy estimates were not more likely to be reported in a full-text publication. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Effective gene editing by high-fidelity base editor 2 in mouse zygotes

    Directory of Open Access Journals (Sweden)

    Puping Liang

    2017-06-01

    Full Text Available ABSTRACT Targeted point mutagenesis through homologous recombination has been widely used in genetic studies and holds considerable promise for repairing disease-causing mutations in patients. However, problems such as mosaicism and low mutagenesis efficiency continue to pose challenges to clinical application of such approaches. Recently, a base editor (BE system built on cytidine (C deaminase and CRISPR/Cas9 technology was developed as an alternative method for targeted point mutagenesis in plant, yeast, and human cells. Base editors convert C in the deamination window to thymidine (T efficiently, however, it remains unclear whether targeted base editing in mouse embryos is feasible. In this report, we generated a modified high-fidelity version of base editor 2 (HF2-BE2, and investigated its base editing efficacy in mouse embryos. We found that HF2-BE2 could convert C to T efficiently, with up to 100% biallelic mutation efficiency in mouse embryos. Unlike BE3, HF2-BE2 could convert C to T on both the target and non-target strand, expanding the editing scope of base editors. Surprisingly, we found HF2-BE2 could also deaminate C that was proximal to the gRNA-binding region. Taken together, our work demonstrates the feasibility of generating point mutations in mouse by base editing, and underscores the need to carefully optimize base editing systems in order to eliminate proximal-site deamination.

  14. Observing Optional Number in DDC Edition 23

    Directory of Open Access Journals (Sweden)

    Rotmianto Mohamad

    2018-01-01

    Full Text Available Dewey Decimal Classification is a most popular classification system in the world because of its completeness and most up-to-date. There are many optional number in this classification system, although it rarely to be discussed even it is important to known well about that optional number, especially for a librarian as classifier. This paper is a literature study about Dewey Decimal Classification Edition 23, to describe about optional numbers, particularly the number in relationship with Indonesia’s subject and discipline. This paper is to avoid misunderstanding in interpreted about optional number among librarians, especially for who that does not understand well about optional numbers.

  15. MANAJEMEN EDITING POST PRODUCTION PROGRAM CURRENT AFFAIR DI TVONE

    Directory of Open Access Journals (Sweden)

    Ridho Azlam Ambo Asse

    2016-11-01

    Full Text Available Management is the art of completing the work through others. In an organization there are various components that are structured and coordinated in the movement toward shared vision and mission. Management is looking for that component to move under coordination, pressure, and problems that hit. Editing management, especially for the current affair type program, has a special purpose. Not just the speed of productivity that is based on the ability of individual editors. This research is done to know the process of stage editor in work. The process of managing files, data management, human resources, tools, facilities, scheduling, until the pattern of editing stage in one of the national media industry. This study concludes that the current affair program management editing system based on the concept of planning, organizing, implementation, supervision, and productivity management is done by Top Down method from top to bottom in the management of currenf affair tvOne editing program. What gets from above during a pre-production meeting of a program. Then coordinate with the supervisor and then delegate down to be implemented according to the agreed plan and in accordance with the duties and functions of both the production team and the editor.   Manajemen merupakan seni menyelesaikan pekerjaan melalui orang lain. Dalam sebuah organisasi terdapat berbagai macam komponen yang terstruktur dan terkordinasi dalam gerakan menuju visi dan misi bersama. Manajemen ialah mencari agar komponen tersebut dapat bergerak dibawah koordinasi, tekanan, dan masalah yang menerpa. Manajemen editing khususnya untuk program berjenis current affair, memiliki tujuan khusus. Tidak sekedar kecepatan produktifitas yang didasarkan pada kemampuan individu editor. Penelitian yang dilakukan ini untuk mengetahui proses tahapan editor dalam bekerja. Proses mengelola file, pengelolaan data, sumber daya manusia, alat, fasilitas, penjadwalan, hingga pola tahapan editing pada salah

  16. Review of the Book “Digital Labor: The Internet as Playground and Factory”, Edited by Trebor Scholz

    Directory of Open Access Journals (Sweden)

    Sebastian Sevignani

    2012-12-01

    Full Text Available This article is a review of the collected volume Digital Labor: The Internet as Playground and Factory, edited by Trebor Scholz (2013 and published by Routledge, New York. The author introduces the articles, discusses them briefly, and gives an overall evaluation of the book.

  17. South African Risk and Vulnerability Atlas: Understanding the Social & Environmental Implications of Global Change. 2nd edition

    CSIR Research Space (South Africa)

    Mambo, Julia

    2017-12-01

    Full Text Available The success of the first edition of the South African Risk and Vulnerability Atlas (SARVA), both as a publication and at COP17 (17th meeting of the ‘Conference of the Parties’ of the international treaty known as the United Nations Framework...

  18. Wikipedia Culture Gap: Quantifying Content Imbalances Across 40 Language Editions

    Directory of Open Access Journals (Sweden)

    Marc Miquel-Ribé

    2018-06-01

    Full Text Available The online encyclopedia Wikipedia is the largest general information repository created through collaborative efforts from all over the globe. Despite the project's goal being to achieve the sum of human knowledge, there are strong content imbalances across the language editions. In order to quantify and investigate these imbalances, we study the impact of cultural context in 40 language editions. To this purpose, we developed a computational method to identify articles that can be related to the editors' cultural context associated to each Wikipedia language edition. We employed a combination of strategies taking into account geolocated articles, specific keywords and categories, as well as links between articles. We verified the method's quality with manual assessment and found an average precision of 0.92 and an average recall of 0.95. The results show that about a quarter of each Wikipedia language edition is dedicated to represent the corresponding cultural context. Although a considerable part of this content was created during the first years of the project, its creation is sustained over time. An analysis of cross-language coverage of this content shows that most of it is unique in its original language, and reveals special links between cultural contexts; at the same time, it highlights gaps where the encyclopedia could extend its content. The approach and findings presented in this study can help to foster participation and inter-cultural enrichment of Wikipedias. The datasets produced are made available for further research.

  19. Copies of editions from V. Vernadsky National Library of Ukraine Old Printed and Rare Editions Department fonds, not mentioned in «Svodnyi catalog knig na inostrannyh yazykah, izdannyh v Rossii v XVIII veke»

    Directory of Open Access Journals (Sweden)

    Rudakova Y.

    2014-01-01

    Full Text Available «Svodnyi catalog knig na inostrannyh yazykah, izdannyh v Rossii v XVIII veke (1701-1800» is the first and currently the only bibliographic index of books in foreign languages, printed in Russian Empire typographies in the 18th century. The catalogue was arranged on the basis of fonds of 14 major libraries of former USSR, including the contemporary V. Vernadsky National Library of Ukraine. However, a number of books, not mentioned in the catalogue in question, were found in the fonds of Old Printed and Rare Editions Department of V. Vernadsky National Library of Ukraine. Also a list of editions, which descriptions in the catalogue need to be completed or corrected, was composed. This information will be reflected in the fifth volume of the catalogue that is being prepared for publication in the Library of the Russian Academy of Sciences. The article intends to inform about these additions. They are displayed by two lists. The first list contains numbers of editions, which descriptions in the catalogue are to be improved. The second list contains editions from the fonds of V. Vernadsky National Library of Ukraine Old Printed and Rare Editions Department, which are not mentioned in the catalogue. The lists of additions are supplemented with brief characteristics of the catalogue.

  20. Introduction to Educational Administration: Standards, Theories, and Practice. Second Edition

    Science.gov (United States)

    Fiore, Douglas J.

    2009-01-01

    Organized around the ISLLC standards, this text introduces students to the concepts and theories of educational leadership. The new edition adds coverage of such topics as data usage, ethics, innovative hiring practices, and student discipline. Appearing in the second edition are chapter-ending sections called "Point-Counterpoint" which prompt…

  1. Finite Unification: Theory, Models and Predictions

    CERN Document Server

    Heinemeyer, S; Zoupanos, G

    2011-01-01

    All-loop Finite Unified Theories (FUTs) are very interesting N=1 supersymmetric Grand Unified Theories (GUTs) realising an old field theory dream, and moreover have a remarkable predictive power due to the required reduction of couplings. The reduction of the dimensionless couplings in N=1 GUTs is achieved by searching for renormalization group invariant (RGI) relations among them holding beyond the unification scale. Finiteness results from the fact that there exist RGI relations among dimensional couplings that guarantee the vanishing of all beta-functions in certain N=1 GUTs even to all orders. Furthermore developments in the soft supersymmetry breaking sector of N=1 GUTs and FUTs lead to exact RGI relations, i.e. reduction of couplings, in this dimensionful sector of the theory, too. Based on the above theoretical framework phenomenologically consistent FUTs have been constructed. Here we review FUT models based on the SU(5) and SU(3)^3 gauge groups and their predictions. Of particular interest is the Hig...

  2. Monolingual accounting dictionaries for EFL text production

    Directory of Open Access Journals (Sweden)

    Sandro Nielsen

    2006-10-01

    Full Text Available Monolingual accounting dictionaries are important for producing financial reporting texts in English in an international setting, because of the lack of specialised bilingual dictionaries. As the intended user groups have different factual and linguistic competences, they require specific types of information. By identifying and analysing the users' factual and linguistic competences, user needs, use-situations and the stages involved in producing accounting texts in English as a foreign language, lexicographers will have a sound basis for designing the optimal English accounting dictionary for EFL text production. The monolingual accounting dictionary needs to include information about UK, US and international accounting terms, their grammatical properties, their potential for being combined with other words in collocations, phrases and sentences in order to meet user requirements. Data items that deal with these aspects are necessary for the international user group as they produce subject-field specific and register-specific texts in a foreign language, and the data items are relevant for the various stages in text production: draft writing, copyediting, stylistic editing and proofreading.

  3. Squark and slepton masses as probes of supersymmetric SO(10) unification

    Energy Technology Data Exchange (ETDEWEB)

    Balasubramanian Ananthanarayan; P. N. Pandita

    2003-09-01

    We carry out a detailed analysis of the non-universal supersymmetry breaking scalar masses arising in SO(10) supersymmetric unification. By considering patterns of squark and slepton masses, we show that a set of sum rules for the sfermion masses is independent of the manner in which SO(10) breaks. We discuss the reasons for this remarkable result. The phenomenology arising from such non-universality is shown to be practically unaffected by the symmetry breaking pattern.

  4. Physics beyond the standard model in the non-perturbative unification scheme

    International Nuclear Information System (INIS)

    Kapetanakis, D.; Zoupanos, G.

    1990-01-01

    The non-perturbative unification scenario predicts reasonably well the low energy gauge couplings of the standard model. Agreement with the measured low energy couplings is obtained by assuming certain kind of physics beyond the standard model. A number of possibilities for physics beyond the standard model is examined. The best candidates so far are the standard model with eight fermionic families and a similar number of Higgs doublets, and the supersymmetric standard model with five families. (author)

  5. Beyond genes, proteins, and abstracts: Identifying scientific claims from full-text biomedical articles.

    Science.gov (United States)

    Blake, Catherine

    2010-04-01

    Massive increases in electronically available text have spurred a variety of natural language processing methods to automatically identify relationships from text; however, existing annotated collections comprise only bioinformatics (gene-protein) or clinical informatics (treatment-disease) relationships. This paper introduces the Claim Framework that reflects how authors across biomedical spectrum communicate findings in empirical studies. The Framework captures different levels of evidence by differentiating between explicit and implicit claims, and by capturing under-specified claims such as correlations, comparisons, and observations. The results from 29 full-text articles show that authors report fewer than 7.84% of scientific claims in an abstract, thus revealing the urgent need for text mining systems to consider the full-text of an article rather than just the abstract. The results also show that authors typically report explicit claims (77.12%) rather than an observations (9.23%), correlations (5.39%), comparisons (5.11%) or implicit claims (2.7%). Informed by the initial manual annotations, we introduce an automated approach that uses syntax and semantics to identify explicit claims automatically and measure the degree to which each feature contributes to the overall precision and recall. Results show that a combination of semantics and syntax is required to achieve the best system performance. 2009 Elsevier Inc. All rights reserved.

  6. Novel Features and Considerations for ERA and Regulation of Crops Produced by Genome Editing

    Directory of Open Access Journals (Sweden)

    Nina Duensing

    2018-06-01

    Full Text Available Genome editing describes a variety of molecular biology applications enabling targeted and precise alterations of the genomes of plants, animals and microorganisms. These rapidly developing techniques are likely to revolutionize the breeding of new crop varieties. Since genome editing can lead to the development of plants that could also have come into existence naturally or by conventional breeding techniques, there are strong arguments that these cases should not be classified as genetically modified organisms (GMOs and be regulated no differently from conventionally bred crops. If a specific regulation would be regarded necessary, the application of genome editing for crop development may challenge risk assessment and post-market monitoring. In the session “Plant genome editing—any novel features to consider for ERA and regulation?” held at the 14th ISBGMO, scientists from various disciplines as well as regulators, risk assessors and potential users of the new technologies were brought together for a knowledge-based discussion to identify knowledge gaps and analyze scenarios for the introduction of genome-edited crops into the environment. It was aimed to enable an open exchange forum on the regulatory approaches, ethical aspects and decision-making considerations.

  7. Full-text automated detection of surgical site infections secondary to neurosurgery in Rennes, France.

    Science.gov (United States)

    Campillo-Gimenez, Boris; Garcelon, Nicolas; Jarno, Pascal; Chapplain, Jean Marc; Cuggia, Marc

    2013-01-01

    The surveillance of Surgical Site Infections (SSI) contributes to the management of risk in French hospitals. Manual identification of infections is costly, time-consuming and limits the promotion of preventive procedures by the dedicated teams. The introduction of alternative methods using automated detection strategies is promising to improve this surveillance. The present study describes an automated detection strategy for SSI in neurosurgery, based on textual analysis of medical reports stored in a clinical data warehouse. The method consists firstly, of enrichment and concept extraction from full-text reports using NOMINDEX, and secondly, text similarity measurement using a vector space model. The text detection was compared to the conventional strategy based on self-declaration and to the automated detection using the diagnosis-related group database. The text-mining approach showed the best detection accuracy, with recall and precision equal to 92% and 40% respectively, and confirmed the interest of reusing full-text medical reports to perform automated detection of SSI.

  8. Full text publication rates of studies presented at an international emergency medicine scientific meeting.

    Science.gov (United States)

    Chan, Jannet W M; Graham, Colin A

    2011-09-01

    The publication rate of full text papers following an abstract presentation at a medical conference is variable, and few studies have examined the situation with respect to international emergency medicine conferences. This retrospective study aimed to identify the publication rate of abstracts presented at the 2006 International Conference on Emergency Medicine (ICEM) held in Halifax, Canada. The full text publication rate was 33.2%, similar to previous emergency medicine meetings. English language barriers may play a role in the low publication rate seen.

  9. Fundamentals of Welding. Teacher Edition [and] Student Edition [and] Student Workbook. Second Edition.

    Science.gov (United States)

    Fortney, Clarence; Gregory, Mike; New, Larry

    Teacher and student editions and a student workbook for fundamentals of welding comprise the first of six in a series of competency-based instructional materials for welding programs. Introductory pages in the teacher edition are training and competency profile, instructional/task analysis, basic skills icons and classifications, basic skills…

  10. Full Text or Abstract? : Examining Topic Coherence Scores Using Latent Dirichlet Allocation

    NARCIS (Netherlands)

    Syed, S.; Spruit, M.

    2017-01-01

    This paper assesses topic coherence and human topic ranking of uncovered latent topics from scientific publications when utilizing the topic model latent Dirichlet allocation (LDA) on abstract and full-text data. The coherence of a topic, used as a proxy for topic quality, is based on the

  11. Understanding disciplinary vocabularies using a full-text enabled domain-independent term extraction approach.

    Science.gov (United States)

    Yan, Erjia; Williams, Jake; Chen, Zheng

    2017-01-01

    Publication metadata help deliver rich analyses of scholarly communication. However, research concepts and ideas are more effectively expressed through unstructured fields such as full texts. Thus, the goals of this paper are to employ a full-text enabled method to extract terms relevant to disciplinary vocabularies, and through them, to understand the relationships between disciplines. This paper uses an efficient, domain-independent term extraction method to extract disciplinary vocabularies from a large multidisciplinary corpus of PLoS ONE publications. It finds a power-law pattern in the frequency distributions of terms present in each discipline, indicating a semantic richness potentially sufficient for further study and advanced analysis. The salient relationships amongst these vocabularies become apparent in application of a principal component analysis. For example, Mathematics and Computer and Information Sciences were found to have similar vocabulary use patterns along with Engineering and Physics; while Chemistry and the Social Sciences were found to exhibit contrasting vocabulary use patterns along with the Earth Sciences and Chemistry. These results have implications to studies of scholarly communication as scholars attempt to identify the epistemological cultures of disciplines, and as a full text-based methodology could lead to machine learning applications in the automated classification of scholarly work according to disciplinary vocabularies.

  12. Mikhail Lomonosov’s “Short Manual in Rhetoric”: The History of the First Edition from 1748

    Directory of Open Access Journals (Sweden)

    Andrei A. Kostin

    2017-12-01

    Full Text Available The article studies the first editions of Mikhail Lomonosov’s “Kratkoe rukovodstvo k krasnorechiiu (A Short Manual in Rhetoric,” issued by the Academy of Sciences in 1748 and 1765. The textual variations help us demonstrate that the common view on the history of these texts as directly descending from the only extant set of proof-reads is false. With textual and codicological analysis (including the presentation of three unique copies of the first edition, and using the records of the Academy Chancellery and Typography, we argue that the creation of the unique varying copies of the first edition were caused not only by the fire in the Academy building (December 5, 1747, but also by the lack of paper in the Typography’s stock and the fact, that the most part of the book had not yet been written by the time it started to print. For more than a year Lomonosov provided the typography with only small portions of the text, and thus the reprinting the portion of the print run damaged by the fire coincided with the creation of the last chapters. This made it possible for Lomonosov to radically rewrite the first paragraphs of an early chapter “On fictions,” turning it into a theoretical text, legitimizing the fiction genres, which became the crucial part of the Academy print in 1747/48 (Volchkov’s translation of the Aesop’s Fables; the translations of the Fenelons’ Telemaque and Barclay’s Argenis; Sumarokov’s tragedies. The article concludes with a verified stemma of the print sources of the “Kratkoe rukovodstvo,” issued during Lomonosov’s lifetime; and the Moscow edition (1759–1765 is argued to present the latest authorized text.

  13. Financial Accounting for Local and State School Systems: 2014 Edition. NCES 2015-347

    Science.gov (United States)

    Allison, Gregory S.

    2015-01-01

    The 2014 edition of "Financial Accounting for Local and State School Systems" updates the 2009 (see ED505993) and 2003 editions of the handbook. The 2003 edition was the work of the NCES National Forum on Education Statistics, Core Finance Data Task Force. That task force systematically rewrote nearly the entire text, incorporating new…

  14. A proposal for unification of fatigue crack growth law

    Science.gov (United States)

    Kobelev, V.

    2017-05-01

    In the present paper, the new fractional-differential dependences of cycles to failure for a given initial crack length upon the stress amplitude in the linear fracture approach are proposed. The anticipated unified propagation function describes the infinitesimal crack length growths per increasing number of load cycles, supposing that the load ratio remains constant over the load history. Two unification fractional-differential functions with different number of fitting parameters are proposed. An alternative, threshold formulations for the fractional-differential propagation functions are suggested. The mean stress dependence is the immediate consequence from the considered laws. The corresponding formulas for crack length over the number of cycles are derived in closed form.

  15. Retrieval of publications addressing shared decision making: an evaluation of full-text searches on medical journal websites.

    Science.gov (United States)

    Blanc, Xavier; Collet, Tinh-Hai; Auer, Reto; Iriarte, Pablo; Krause, Jan; Légaré, France; Cornuz, Jacques; Clair, Carole

    2015-04-07

    Full-text searches of articles increase the recall, defined by the proportion of relevant publications that are retrieved. However, this method is rarely used in medical research due to resource constraints. For the purpose of a systematic review of publications addressing shared decision making, a full-text search method was required to retrieve publications where shared decision making does not appear in the title or abstract. The objective of our study was to assess the efficiency and reliability of full-text searches in major medical journals for identifying shared decision making publications. A full-text search was performed on the websites of 15 high-impact journals in general internal medicine to look up publications of any type from 1996-2011 containing the phrase "shared decision making". The search method was compared with a PubMed search of titles and abstracts only. The full-text search was further validated by requesting all publications from the same time period from the individual journal publishers and searching through the collected dataset. The full-text search for "shared decision making" on journal websites identified 1286 publications in 15 journals compared to 119 through the PubMed search. The search within the publisher-provided publications of 6 journals identified 613 publications compared to 646 with the full-text search on the respective journal websites. The concordance rate was 94.3% between both full-text searches. Full-text searching on medical journal websites is an efficient and reliable way to identify relevant articles in the field of shared decision making for review or other purposes. It may be more widely used in biomedical research in other fields in the future, with the collaboration of publishers and journals toward open-access data.

  16. SO(10) - Grand unification and fermion masses

    International Nuclear Information System (INIS)

    Oezer, A.D.

    2005-01-01

    In this work, we study SO(10) grand unification in its full extent by using different explicit matrix representations which exhibit the structure of SO(10) in a very transparent way. Our approach consists mainly of two stages: We derive the explicit expressions of the mass-eigenvalues and mass-eigenstates of the physical gauge bosons from a mass squared-matrix that contains all the information about the mixing parameters among the gauge fields and the phases which are sources for CP violation. In the light of this analysis, we derive the explicit expressions for the interaction Lagrangians of the charged currents, the neutral currents and the charged and colored currents in SO(10). We present explicit expressions of the vector and axial-vector couplings of the two neutral currents in SO(10). We show how the baryon, lepton and baryon minus lepton number violating processes and their explicit CP violating phases are accommodated in the SO(10) theory. The Higgs potential that we use to implement in the Higgs mechanism is constructed in a most general fashion through a careful study of the Higgs fields of SO(10), where we give special emphasis on illustrating the explicit matrix representation of these Higgs fields. The potential part of the Higgs Lagrangian will give us the properties of the minimum of the vacuum, and the kinetic part will give us the mass-squared matrix of the gauge bosons via spontaneous symmetry breakdown. The same Higgs multiplets will be coupled to fermions through a democratic Yukawa matrix. Thereby, we derive explicit expressions for the fermion masses of the third family including Majorana and Dirac masses for neutrinos. We introduce a flavor-eigenbasis for neutrinos and find the mass-eigenstates and mass-eigenvalues of the neutrinos. Explicit expressions for CP violation in the neutrino sector are obtained. In the second stage of our work, we evaluate all the above mentioned quantities. In addition, we present the values of the physical

  17. Particle Physics, 2nd Edition

    Science.gov (United States)

    Martin, B. R.; Shaw, G.

    1998-01-01

    Particle Physics, Second Edition is a concise and lucid account of the fundamental constituents of matter. The standard model of particle physics is developed carefully and systematically, without heavy mathematical formalism, to make this stimulating subject accessible to undergraduate students. Throughout, the emphasis is on the interpretation of experimental data in terms of the basic properties of quarks and leptons, and extensive use is made of symmetry principles and Feynman diagrams, which are introduced early in the book. The Second Edition brings the book fully up to date, including the discovery of the top quark and the search for the Higgs boson. A final short chapter is devoted to the continuing search for new physics beyond the standard model. Particle Physics, Second Edition features: * A carefully structured and written text to help students understand this exciting and demanding subject. * Many worked examples and problems to aid student learning. Hints for solving the problems are given in an Appendix. * Optional "starred" sections and appendices, containing more specialised and advanced material for the more ambitious reader.

  18. Full text

    African Journals Online (AJOL)

    IndexCopernicus Portal System

    2009-07-20

    Jul 20, 2009 ... Table 1: Influenza pandemics of the 20th and 21st century. Name of ... could be responsible for the rapid human -to- human transmission [21]. Using evolutionary analysis to estimate the timescale of the origins, Smith and his research team from The. University of ... The biology of influenza A viruses is very.

  19. Full text

    African Journals Online (AJOL)

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    –60 years, in Al-Jala Women Hospital in. Tripoli, Libya. Haemoglobin concentration was measured using an automated haematology analyzer. ... i.e. by relatives and friends of the patient needing blood. A .... More attention should be given.

  20. Full text

    African Journals Online (AJOL)

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    2009-01-11

    Jan 11, 2009 ... battery, retail for approximately £30GBP although bulk buying ..... care to store them carefully. Electrode costs .... nerve stimulation does not relieve in labour pain: updated ... (Online : Update Software), 2003(3): p. CD003222.

  1. Full text

    African Journals Online (AJOL)

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    Case presentation. A seventy five year old Libyan man was seen in the urology department of Tripoli Medical Centre, Tripoli, Libya with six month history of left loin pain. The patient noted a mass in the left loin two days before he was assessed in the hospital. Also he started to vomit. There was no history of haematuria.

  2. Full text

    African Journals Online (AJOL)

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    impact of using a robotic dispensing machine in community pharmacies was gathered using a structured questionnaire and analysed in ... dispensing time was also shorter and staff satisfaction increased. ... reference customers who were using a ROWA robotic .... Costs situation Purchase price Stock value Personnel costs.

  3. Full text

    African Journals Online (AJOL)

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    release of intracellular myocyte components. Clinical sequelae to rhabdomyolysis include hypovolemia, hyperkalemia, metabolic acidosis and acute renal failure which is the most serious complication. Renal failure is caused by renal vasoconstriction, myoglobin and heme protein toxicity. Usual explanations of the cause of.

  4. Full text

    African Journals Online (AJOL)

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    Original Article. Effects of Gender and Seasonal Variation on the Prevalence of. Bacterial Septicaemia Among Young Children in Benin City,. Nigeria. Omoregie R1,2, Egbe CA2, Ogefere HO1,3, Igbarumah I2, Omijie RE2. 1School of Medical Laboratory Sciences, 2Department of Medical Microbiology, University of Benin.

  5. Full text

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    healing process when wound tensile strength is very low or absent (days 0-30). It is during this time, when .... and two (4.5%) were supraumbilical. Table 1: Age distribution and the outcome of surgery in the 44 women with incisional hernia. Variable. Frequency. Percentage. Age. 60. 9. 15. 10. 6. 4.

  6. Full text

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    fishermen were enrolled at three Marine stations in Basra, Iraq. Demographic data, types .... that are used to sting and kill their prey or for defense. ... cardiotoxic, and dermatonecrotic toxins [1,6]. Figure 3: 4 ... May last a few weeks. The hands ...

  7. Full text

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    from Turkey, Mexico, Brazil, USA, and Spain determined some criteria in favor ... female gender, and higher level of education. [9-14]. ... teachers and/or workers in that facility. Then a random ..... Psychosocial profile in favor of organ donation.

  8. Full text

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    1Department of Surgery, Obafemi Awolowo, 2Department of Community Health,. Obafemi ... the use of mesh, either open or laparoscopic [15,21], but this ... recurrence. METHODS AND PATIENTS .... TAH-BSO* = Total abdominal hysterectomy and bilateral salpingoophorectomy. Recurrent I.H. # = Recurrent inguinal hernia.

  9. Full text

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    Figure 2 axial CT section with contrast media showing extension of lesion. Figure 3 Photomicrograph revealing many dilated cavernous lymphatic channels filled with eosinophilic coagulum. (Haematoxylin and Eosin section Orginal magnification 40 X). Discussion. Cystic hygroma, known as cystic lymphangioma is a.

  10. Full text

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    Abstract; The expression of EGFR and p53 has not been adequately studied as a prognostic tool in urinary bladder tumors. We analyzed 74 bladder cancer samples from Egypt for EGFR and p53 expression using immunohistochemistry. The tumors .... have some potential value in differential diagnosis of problem cases, but ...

  11. Full text

    African Journals Online (AJOL)

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    receptor; TNF-α: Tumor Necrosis Factor–alpha; TGF-β1: transforming growth factor-β1. INTRODUCTION .... hormones that mediate inflammatory and immune responses in a ..... score, lactate, and base deficit), as well as treatment with agents ...

  12. Full text

    African Journals Online (AJOL)

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    Abstract; The detection of single base mismatches in DNA is important for diagnostics, treatment of ... nucleic acid detectors, and show how such exciplexes can register the presence of .... Titration experiments were carried out using a stock.

  13. Full text

    African Journals Online (AJOL)

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    2009-05-03

    May 3, 2009 ... The patient made an uneventful recovery. The final histopathology report was consistent with metastatic renal carcinoma. The patient was referred to the oncologist but unfortunately defaulted further treatment. . She is currently well and disease free 24 months after metastatectomy. Electronic PDF security ...

  14. Full-text

    African Journals Online (AJOL)

    ADOWIE PERE

    consideration the needs of the current generation without risking ability of future generations to attain their needs. Evaluation of .... If an element or a number such as x and a collection such as A ... defined as definitive and accurate. This also ...

  15. USH2A Gene Editing Using the CRISPR System

    Directory of Open Access Journals (Sweden)

    Carla Fuster-García

    2017-09-01

    Full Text Available Usher syndrome (USH is a rare autosomal recessive disease and the most common inherited form of combined visual and hearing impairment. Up to 13 genes are associated with this disorder, with USH2A being the most prevalent, due partially to the recurrence rate of the c.2299delG mutation. Excluding hearing aids or cochlear implants for hearing impairment, there are no medical solutions available to treat USH patients. The repair of specific mutations by gene editing is, therefore, an interesting strategy that can be explored using the CRISPR/Cas9 system. In this study, this method of gene editing is used to target the c.2299delG mutation on fibroblasts from an USH patient carrying the mutation in homozygosis. Successful in vitro mutation repair was demonstrated using locus-specific RNA-Cas9 ribonucleoproteins with subsequent homologous recombination repair induced by an engineered template supply. Effects on predicted off-target sites in the CRISPR-treated cells were discarded after a targeted deep-sequencing screen. The proven effectiveness and specificity of these correction tools, applied to the c.2299delG pathogenic variant of USH2A, indicates that the CRISPR system should be considered to further explore a potential treatment of USH. Keywords: Usher syndrome, USH2A, c.2299delG, CRISPR, gene editing, RNPs

  16. Newer Gene Editing Technologies toward HIV Gene Therapy

    Directory of Open Access Journals (Sweden)

    Premlata Shankar

    2013-11-01

    Full Text Available Despite the great success of highly active antiretroviral therapy (HAART in ameliorating the course of HIV infection, alternative therapeutic approaches are being pursued because of practical problems associated with life-long therapy. The eradication of HIV in the so-called “Berlin patient” who received a bone marrow transplant from a CCR5-negative donor has rekindled interest in genome engineering strategies to achieve the same effect. Precise gene editing within the cells is now a realistic possibility with recent advances in understanding the DNA repair mechanisms, DNA interaction with transcription factors and bacterial defense mechanisms. Within the past few years, four novel technologies have emerged that can be engineered for recognition of specific DNA target sequences to enable site-specific gene editing: Homing Endonuclease, ZFN, TALEN, and CRISPR/Cas9 system. The most recent CRISPR/Cas9 system uses a short stretch of complementary RNA bound to Cas9 nuclease to recognize and cleave target DNA, as opposed to the previous technologies that use DNA binding motifs of either zinc finger proteins or transcription activator-like effector molecules fused to an endonuclease to mediate sequence-specific DNA cleavage. Unlike RNA interference, which requires the continued presence of effector moieties to maintain gene silencing, the newer technologies allow permanent disruption of the targeted gene after a single treatment. Here, we review the applications, limitations and future prospects of novel gene-editing strategies for use as HIV therapy.

  17. Design of an On-Line Query Language for Full Text Patent Search.

    Science.gov (United States)

    Glantz, Richard S.

    The design of an English-like query language and an interactive computer environment for searching the full text of the U.S. patent collection are discussed. Special attention is paid to achieving a transparent user interface, to providing extremely broad search capabilities (including nested substitution classes, Kleene star events, and domain…

  18. Full Inclusion: Understanding the Role of Gay and Lesbian Texts and Films in Teacher Education Classrooms

    Science.gov (United States)

    Hermann-Wilmarth, Jill M.

    2007-01-01

    This paper identifies some of the resources the author has found and used to help future teachers become fully inclusive teachers, particularly of early elementary students. Through sharing these resources--children's literature, a children's literature textbook, edited books for teacher educators and pre- and inservice teachers, and a video--the…

  19. LevelMerge: Collaborative Game Level Editing by Merging Labeled Graphs

    OpenAIRE

    Santoni, Christian; Salvati, Gabriele; Tibaldo, Valentina; Pellacini, Fabio

    2016-01-01

    Game level editing is the process of constructing a full game level starting from 3D asset libraries, e.g. 3d models, textures, shaders, scripts. In level editing, designers define the look and behavior of the whole level by placing objects, assigning materials and lighting parameters, setting animations and physics properties and customizing the objects AI and behavior by editing scripts. The heterogeneity of the task usually translates to a workflow where a team of people, experts on separa...

  20. Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells.

    Directory of Open Access Journals (Sweden)

    Sanne Hindriksen

    Full Text Available The CRISPR/Cas9 system is a highly effective tool for genome editing. Key to robust genome editing is the efficient delivery of the CRISPR/Cas9 machinery. Viral delivery systems are efficient vehicles for the transduction of foreign genes but commonly used viral vectors suffer from a limited capacity in the genetic information they can carry. Baculovirus however is capable of carrying large exogenous DNA fragments. Here we investigate the use of baculoviral vectors as a delivery vehicle for CRISPR/Cas9 based genome-editing tools. We demonstrate transduction of a panel of cell lines with Cas9 and an sgRNA sequence, which results in efficient knockout of all four targeted subunits of the chromosomal passenger complex (CPC. We further show that introduction of a homology directed repair template into the same CRISPR/Cas9 baculovirus facilitates introduction of specific point mutations and endogenous gene tags. Tagging of the CPC recruitment factor Haspin with the fluorescent reporter YFP allowed us to study its native localization as well as recruitment to the cohesin subunit Pds5B.

  1. Editing of the urease gene by CRISPR-Cas in the diatom Thalassiosira pseudonana

    Directory of Open Access Journals (Sweden)

    Amanda Hopes

    2016-11-01

    Full Text Available Abstract Background CRISPR-Cas is a recent and powerful addition to the molecular toolbox which allows programmable genome editing. It has been used to modify genes in a wide variety of organisms, but only two alga to date. Here we present a methodology to edit the genome of Thalassiosira pseudonana, a model centric diatom with both ecological significance and high biotechnological potential, using CRISPR-Cas. Results A single construct was assembled using Golden Gate cloning. Two sgRNAs were used to introduce a precise 37 nt deletion early in the coding region of the urease gene. A high percentage of bi-allelic mutations (≤61.5% were observed in clones with the CRISPR-Cas construct. Growth of bi-allelic mutants in urea led to a significant reduction in growth rate and cell size compared to growth in nitrate. Conclusions CRISPR-Cas can precisely and efficiently edit the genome of T. pseudonana. The use of Golden Gate cloning to assemble CRISPR-Cas constructs gives additional flexibility to the CRISPR-Cas method and facilitates modifications to target alternative genes or species.

  2. General edition program

    International Nuclear Information System (INIS)

    Vaturi, Sylvain

    1969-01-01

    Computerized edition is essential for data processing exploitation. When a more or less complex edition program is required for each task, then the need for a general edition program become obvious. The aim of this study is to create a general edition program. Universal programs are capable to execute numerous and varied tasks. For a more precise processing, the execution of which is frequently required, the use of a specialized program is preferable because, contradictory to the universal program, it goes straight to the point [fr

  3. An approach to gauge hierarchy in the minimal SU(5) model of grand unification

    International Nuclear Information System (INIS)

    Ghose, P.

    1982-08-01

    It is shown that if all mass generation through spontaneous symmetry breaking is predominantly caused by scalar loops in the minimal SU(5) model of grand unification, it is possible to have an arbitrarily large gauge hierarchy msub(x) >> msub(w) with all Higgs bosons superheavy. No fine tuning is necessary in every order. (author)

  4. The edition from the VNLU fonds, unknown in the bibliography, as a sourcefor the biography of the book owner in the 18th ct. (description of the edition and the copy

    Directory of Open Access Journals (Sweden)

    Zabolotna N.

    2014-01-01

    Full Text Available The research of small (with a small amount of pages editions is now very actual as such publications usually are not covered by most scientific catalogs. This complicates their attribution and primarily their dating because many of these books are undated. The activity of Pochayiv Assumption monastery printing house in the 18th ct., especially in 70’s - 80’s is an example of active publication of such kind of editions. The article is devoted to the copy of the book «Decretum quo Sanctissimus Dominus Noster Clemens Divina Providentiв PP. XIV. concedit Proto-Archmandritж Congregationis S. Basilii Magni Ruthenorum, nec non cжteris Archimadritis ejusdem Congregationis, eorumquи in perpetuum Successoribus, facuttalem impertendi Benedictionem cum Jndulgentia Plenaria in articulo mortis» [Pochayiv: Typography of Assumption Monastery, between 1772 and 1774], which is not described in the bibliography. The investigated copy is also a document of one of the owners, the Basilian monk Amvrosii Lukasevych. The article has appendices with scientific descriptions of the edition and the copy.

  5. How European unification has shaped the debate on measuring international financial integration

    OpenAIRE

    Pieterse-Bloem, Mary; Eijffinger, Sylvester

    2013-01-01

    textabstractIn this paper we analyse a chronicle of economic theory on international financial integration post-WWII to the present date. Our focus is on theories that have somehow quantify the state and speed of international financial integration. We are able to contrast and compare three distinct strands that have brought forward conditions for its measurement. It is shown that European unification provides much of the empirical testing ground for these measures of international financial ...

  6. Fine and Predictable Tuning of TALEN Gene Editing Targeting for Improved T Cell Adoptive Immunotherapy

    Directory of Open Access Journals (Sweden)

    Anne-Sophie Gautron

    2017-12-01

    Full Text Available Using a TALEN-mediated gene-editing approach, we have previously described a process for the large-scale manufacturing of “off-the-shelf” CAR T cells from third-party donor T cells by disrupting the gene encoding TCRα constant chain (TRAC. Taking advantage of a previously described strategy to control TALEN targeting based on the exclusion capacities of non-conventional RVDs, we have developed highly efficient and specific nucleases targeting a key T cell immune checkpoint, PD-1, to improve engineered CAR T cells’ functionalities. Here, we demonstrate that this approach allows combined TRAC and PDCD1 TALEN processing at the desired locus while eliminating low-frequency off-site processing. Thus, by replacing few RVDs, we provide here an easy and rapid redesign of optimal TALEN combinations. We anticipate that this method can greatly benefit multiplex editing, which is of key importance especially for therapeutic applications where high editing efficiencies need to be associated with maximal specificity and safety.

  7. Network Dependency in Migration Flows – A Space-time Analysis for Germany since Re-unification

    DEFF Research Database (Denmark)

    Mitze, Timo

    The contribution of this paper is to analyse the role of network interdependencies in a dynamic panel data model for German internal migration fl ows since re-unification. So far, a capacious account of spatial patterns in German migration data is still missing in the empirical literature. In the...

  8. Site-Specific Integration of Exogenous Genes Using Genome Editing Technologies in Zebrafish

    Directory of Open Access Journals (Sweden)

    Atsuo Kawahara

    2016-05-01

    Full Text Available The zebrafish (Danio rerio is an ideal vertebrate model to investigate the developmental molecular mechanism of organogenesis and regeneration. Recent innovation in genome editing technologies, such as zinc finger nucleases (ZFNs, transcription activator-like effector nucleases (TALENs and the clustered regularly interspaced short palindromic repeats (CRISPR/CRISPR associated protein 9 (Cas9 system, have allowed researchers to generate diverse genomic modifications in whole animals and in cultured cells. The CRISPR/Cas9 and TALEN techniques frequently induce DNA double-strand breaks (DSBs at the targeted gene, resulting in frameshift-mediated gene disruption. As a useful application of genome editing technology, several groups have recently reported efficient site-specific integration of exogenous genes into targeted genomic loci. In this review, we provide an overview of TALEN- and CRISPR/Cas9-mediated site-specific integration of exogenous genes in zebrafish.

  9. Genome editing of human pluripotent stem cells to generate human cellular disease models

    Directory of Open Access Journals (Sweden)

    Kiran Musunuru

    2013-07-01

    Full Text Available Disease modeling with human pluripotent stem cells has come into the public spotlight with the awarding of the Nobel Prize in Physiology or Medicine for 2012 to Drs John Gurdon and Shinya Yamanaka for the discovery that mature cells can be reprogrammed to become pluripotent. This discovery has opened the door for the generation of pluripotent stem cells from individuals with disease and the differentiation of these cells into somatic cell types for the study of disease pathophysiology. The emergence of genome-editing technology over the past few years has made it feasible to generate and investigate human cellular disease models with even greater speed and efficiency. Here, recent technological advances in genome editing, and its utility in human biology and disease studies, are reviewed.

  10. Enhancing Learner Autonomy in an On-line Editing Programme

    Directory of Open Access Journals (Sweden)

    Hebe Wong

    2011-09-01

    Full Text Available Little (1999 argues that in formal educational contexts, “the basis of learner autonomy is acceptance of responsibility for one’s own learning” (p.11. An autonomous learner takes responsibility for various aspects of learning (Benson & Voller, 1997; Holec, 1981. This study examines how learner autonomy opportunities were provided at various stages of writing in an on-line editing programme for a group of electronic engineering students and how the students took charge of their language learning when receiving feedback on their technical writing. The impact on their own learning effectiveness of the decisions students made is also discussed.

  11. Gauge-Higgs unification with brane kinetic terms

    International Nuclear Information System (INIS)

    Aranda, Alfredo; Diaz-Cruz, J. Lorenzo

    2006-01-01

    By identifying the Higgs field as an internal component of a higher-dimensional gauge field it is possible to solve the little hierarchy problem. The construction of a realistic model that incorporates such a gauge-Higgs unification is an important problem that demands attention. In fact, several attempts in this direction have already been put forward. In this Letter we single out one such attempt, a 6D SU(3) extended electroweak theory, where it is possible to obtain a Higgs mass prediction in accord with global fits. One shortcoming of the model is its prediction for the Weinberg angle, it is too large. We slightly modify the model by including brane kinetic terms in a way motivated by the orbifold action on the 6D fields. We show that in this way it is possible to obtain the correct Weinberg angle while keeping the desired results in the Higgs sector

  12. 10. National Nuclear Science and Technologies Congress Proceedings Full Texts Volume 1

    International Nuclear Information System (INIS)

    2009-01-01

    X. National Nuclear Science and Technologies Congress was held on 6-9 October 2009 in Mugla, Turkey in the course of collaborative organization undertaken by Turkish Atomic Energy Authority, Mugla University and Sitki Kocman Foundation. This first volume of Proceedings Book contains 75 submitted presentations and 36 of them are full texts on applications of nuclear techniques.

  13. Trains and the Italian Unification: the Time of the Railways Buildings

    Directory of Open Access Journals (Sweden)

    Stefano Maggi

    2011-04-01

    Full Text Available The physical construction of modern Italy began in 1861, with the foundation of the Kingdom of Italy. The historical period coincided with the early industrial development of north-western Italy, and so the new infrastructure system developed in response, on the one hand, to the need to join together all the fragmentary pieces that formed the country and, on the other, to the general tendency to strengthen those areas that were economically and industrially stronger even before unification. The system that was being created in the 1860s by the Italian State before unification suffered continuous interruptions and was substantially without transverse connections, those with more difficult construction caused by the need to cross the Apennines. Within five years, from 1861 to 1866, the size of the railway system doubled, going from little more than 2,000 km to more than 4,000. The management of railway was entrusted to limited companies. The government guaranteed the company a contribution for each kilometer of railway built. In 1863 the tracks extended down the Adriatic coast as far as Brindisi, in order to attract the transit of the India Mail London- Brindisi-Bombay, the most important trade of the world. In 1863 Rome was linked to Naples, in 1864 the line from Bologna to Florence via Pistoia was opened, in 1866 Rome was linked to Florence and Ancona and in 1867 with Pisa. In 1874 the Genoa-Pisa line were completed as far as the frontier with France; later, in 1879 the Naples-Foggia line went into operation. In the same period some of the longer tunnels were opened. Those of Fréjus was realised between 1857 and 1871. The Gottardo tunnel came into being in 1882 and the Sempione tunnel in 1906. The opening of the alpine passes effectively permitted the connection of Italy to central Europe, flinging open the doors to more and more easily reachable markets. In last twenty years of the 19th century, in Italy began the strong development of the

  14. Multiplex editing system

    DEFF Research Database (Denmark)

    2015-01-01

    The present invention relates to a multiplex editing system. The system allows multiple editing of nucleic acid sequences such as genomic sequences, such as knockins of genes of interest in a genome, knockouts of genomic sequences and/or allele replacement. Also provided herein are a method...... for editing nucleic acids and a cell comprising a stably integrated endonuclease....

  15. Introduction to Energy - 2nd Edition

    Science.gov (United States)

    Cassedy, Edward S.; Grossman, Peter Z.

    1998-12-01

    Energy issues such as pollution, resource depletion, global warming, nuclear power and waste are problems that demand timely solutions. This book provides a critical examination of the resources, market forces, and social impacts of modern energy production. The book addresses the dilemmas that have arisen due to society's crucial dependence on energy, particularly fossil fuels, and explores the available alternative energy producing technologies. The second edition has increased emphasis on those issues at the forefront of the current energy debate: energy sustainability, climate change, and the radical restructuring of the power industry due to de-regulation. Assuming no prior technical expertise and avoiding complex mathematical formulation, it is directed at a broad readership. The second edition will follow the first in proving especially useful as a textbook for undergraduate programs in Science, Technology and Society (STS), and as a supplementary text in a variety of courses which touch upon energy studies, including environmental and technology policy, environmental, mineral and business law, energy and resource economics. Fully updated second edition of successful first edition that was adopted on Science, Technology and Society courses Provides a critical examination of all aspects of modern energy production for non-technical readers For a broad readership from a variety of backgrounds

  16. Special Edition: Environment in Sustainable Development

    Directory of Open Access Journals (Sweden)

    Stephen Morse

    2014-11-01

    Full Text Available When we were invited by the editors of Sustainability to put together a special edition on “Environment in Sustainable Development” our first reaction was to question whether this was really needed. After all, the environment has long been regarded as a central plank in sustainability and there are countless articles and books published on an annual basis that explore the impact of our economic and social activities on our environment. Just what is it that a special edition can achieve? What new angles could we hope to provide? Our initial thinking was to link the special edition to a particular, almost unique, location in time rather than space. We are in the process of recovering, albeit stuttering, from the deepest economic crash experienced by the European and North American economies. The crash has brought some national economies to their knees and, if economic commentators are to be believed, almost destroyed the Euro. Recovery from that crash has been slow and it is arguable whether at the time of writing this has developed much momentum. There is still the skewed perception that prosperity equals economic growth and that economic growth can take place without real (sustainable development or by simply implementing austerity measures and surely without people’s participation. An analogy from National Parks worldwide is when conservation agencies try to enforce protection without local people’s support. All such attempts have either failed or resurrected only once people’s involvement was secured and guaranteed. The unidirectional austerity measures imposed mainly in the countries of southern Europe have destroyed social cohesion leaving deeply wounded societies, while at the same time have also put up for grabs important assets (including natural capital in each of these countries and therefore in jeopardy even their long term recovery.

  17. ExpEdit: a webserver to explore human RNA editing in RNA-Seq experiments.

    Science.gov (United States)

    Picardi, Ernesto; D'Antonio, Mattia; Carrabino, Danilo; Castrignanò, Tiziana; Pesole, Graziano

    2011-05-01

    ExpEdit is a web application for assessing RNA editing in human at known or user-specified sites supported by transcript data obtained by RNA-Seq experiments. Mapping data (in SAM/BAM format) or directly sequence reads [in FASTQ/short read archive (SRA) format] can be provided as input to carry out a comparative analysis against a large collection of known editing sites collected in DARNED database as well as other user-provided potentially edited positions. Results are shown as dynamic tables containing University of California, Santa Cruz (UCSC) links for a quick examination of the genomic context. ExpEdit is freely available on the web at http://www.caspur.it/ExpEdit/.

  18. Grand unification and subcritical hybrid inflation

    International Nuclear Information System (INIS)

    Buchmueller, Wilfried; Ishiwata, Koji

    2014-12-01

    We consider hybrid inflation for small couplings of the inflaton to matter such that the critical value of the inflaton field exceeds the Planck mass. It has recently been shown that inflation then continues at subcritical inflaton field values where quantum fluctuations generate an effective inflaton mass. The effective inflaton potential interpolates between a quadratic potential at small field values and a plateau at large field values. An analysis of the allowed parameter space leads to predictions for the scalar spectral index n s and the tensor-to-scalar ratio r similar to those of natural inflation. Using the range for n s and r favoured by the Planck data, we find that the energy scale of the plateau is constrained to the interval (1.6-2.4) x 10 16 GeV which includes the energy scale of gauge coupling unification in the supersymmetric standard model. The tensor-to-scalar ratio is predicted to have the lower bound r>0.049 for 60 e-folds before the end of inflation.

  19. An introduction to programming using visual basic 2012(wvisual studio 2012 express edition dvd) (9th edition)

    CERN Document Server

    Schneider, David I.

    2013-01-01

    An Introduction to Programming Using Visual Basic 2012, Ninth Edition —consistently praised by both students and instructors — is designed for readers with no prior computer programming experience. Now updated for Visual Basic 2012, Schneider focuses on teaching problem-solving skills and sustainable programming skills. A broad range of real-world examples, section-ending exercises, case studies, and programming projects gives readers more hands-on experience than any other Visual Basic book on the market. NEW! This edition is available with MyProgrammingLab, an innovative online homework and assessment tool. Through the power of practice and immediate personalized feedback, MyProgrammingLab helps students fully grasp the logic, semantics, and syntax of programming. Note: If you are purchasing the standalone text or electronic version, MyProgrammingLab does not come automatically packaged with the text. To purchase MyProgrammingLab, please visit: myprogramminglab.com or you can purchase a...

  20. Interactions of cultures and top people of Wikipedia from ranking of 24 language editions.

    Directory of Open Access Journals (Sweden)

    Young-Ho Eom

    Full Text Available Wikipedia is a huge global repository of human knowledge that can be leveraged to investigate interwinements between cultures. With this aim, we apply methods of Markov chains and Google matrix for the analysis of the hyperlink networks of 24 Wikipedia language editions, and rank all their articles by PageRank, 2DRank and CheiRank algorithms. Using automatic extraction of people names, we obtain the top 100 historical figures, for each edition and for each algorithm. We investigate their spatial, temporal, and gender distributions in dependence of their cultural origins. Our study demonstrates not only the existence of skewness with local figures, mainly recognized only in their own cultures, but also the existence of global historical figures appearing in a large number of editions. By determining the birth time and place of these persons, we perform an analysis of the evolution of such figures through 35 centuries of human history for each language, thus recovering interactions and entanglement of cultures over time. We also obtain the distributions of historical figures over world countries, highlighting geographical aspects of cross-cultural links. Considering historical figures who appear in multiple editions as interactions between cultures, we construct a network of cultures and identify the most influential cultures according to this network.

  1. Towards Unification of Methods for Speech, Audio, Picture and Multimedia Quality Assessment

    DEFF Research Database (Denmark)

    Zielinski, S.; Rumsey, F.; Bech, Søren

    2015-01-01

    attempting to “bridge the gap” between the quality assessment methods used in various disciplines are indicated. Prospective challenges faced by researchers in the unification process are outlined. They include development of unified scales, defining unified anchors, integration of objective models......The paper addresses the need to develop unified methods for subjective and objective quality assessment across speech, audio, picture, and multimedia applications. Commonalities and differences between the currently used standards are overviewed. Examples of the already undertaken research...

  2. Tea and cake [second edition

    OpenAIRE

    Wood, Philippa; MacLellan, Tamar

    2011-01-01

    Tea & Cake is an edited version of the original book produced by Philippa Wood in 2007. The book takes a nostalgic look at childhood memories of ‘baking with mother’ or special tea-time treats. The book combines ink-jet printing with typewritten text and rubber stamps; doilly end-papers and embroidered traycloth covers.

  3. Money and Schools. Fifth Edition

    Science.gov (United States)

    Thompson, David C.; Crampton, Faith E.; Wood, R. Craig

    2012-01-01

    In the new edition of this essential, all-inclusive text, the authors provide more important research for future principals and others enrolled in graduate-level school finance courses. Written in a style that is highly readable, the book offers strong connections to real-world experiences. Readers get both a broad overview of funding concepts and…

  4. A new edition of Perrault's Tales: Regina Zilberman resignifies Walcyr Carrasco

    Directory of Open Access Journals (Sweden)

    Anna Olga Prudente de Oliveira

    2016-01-01

    Full Text Available Since the beginning of the 21st century, different Brazilian publishing houses have released Charles Perrault’s Stories or Tales of Olden Days with Morals in editions which present rewritings of the 17th century French author’s tales done by translators and adaptors of great prestige in the translation area or in children’s literature: Mário Laranjeira (Iluminuras, 2007, Maria Luiza Borges (Zahar, 2010, Ivone Benedetti (L&PM, 2012, Rosa Freire d’Aguiar (Companhia das Letrinhas, 2012, Katia Canton (DCL, 2005 and Walcyr Carrasco (Manole, 2009; Moderna, 2013. Besides promoting a rediscovery of the author by the Brazilian reading public, these rewritings – translations and adaptations – also help to promote and value his work, with editions that contain paratexts commenting on Perrault’s life and work as well as on the work done by the translator or adaptor. Considering the visibility of the translator/adaptor’s work provided by the paratexts that accompany the rewritings, this article discusses how a new publishing project is able to resignify a rewriting, in this case, Walcyr Carrasco's adaptation of Perrault’s tales, first launched by Manole (2009 and now in a new edition published by Moderna (2013, with a preface written by Regina Zilberman.

  5. Oxyacetylene Welding and Oxyfuel Cutting. Third Edition. Teacher Edition [and] Student Edition [and] Student Workbook.

    Science.gov (United States)

    Knapp, John; Harper, Eddie

    This Oklahoma curriculum guide, which includes a teacher edition, a student edition, and a student workbook, provides three units for a course on oxyacetylene welding, oxyfuel cutting, and cutting done with alternative fuels such as MAPP, propane, and natural gas. The three units are: "Oxyacetylene Welding"; "Oxyfuel Cutting";…

  6. A text-mining system for extracting metabolic reactions from full-text articles.

    Science.gov (United States)

    Czarnecki, Jan; Nobeli, Irene; Smith, Adrian M; Shepherd, Adrian J

    2012-07-23

    Increasingly biological text mining research is focusing on the extraction of complex relationships relevant to the construction and curation of biological networks and pathways. However, one important category of pathway - metabolic pathways - has been largely neglected.Here we present a relatively simple method for extracting metabolic reaction information from free text that scores different permutations of assigned entities (enzymes and metabolites) within a given sentence based on the presence and location of stemmed keywords. This method extends an approach that has proved effective in the context of the extraction of protein-protein interactions. When evaluated on a set of manually-curated metabolic pathways using standard performance criteria, our method performs surprisingly well. Precision and recall rates are comparable to those previously achieved for the well-known protein-protein interaction extraction task. We conclude that automated metabolic pathway construction is more tractable than has often been assumed, and that (as in the case of protein-protein interaction extraction) relatively simple text-mining approaches can prove surprisingly effective. It is hoped that these results will provide an impetus to further research and act as a useful benchmark for judging the performance of more sophisticated methods that are yet to be developed.

  7. Towards unification of the Vorticity Confinement and Shock Capturing (TVD and ENO/WENO) methods

    Science.gov (United States)

    Sidilkover, David

    2018-04-01

    New multidimensional extensions of the TVD and finite difference ENO/WENO methods for the compressible flow equations are proposed. The novelty of the approach is in the discretization schemes that acquire by means of a single mechanism both shock-capturing and vorticity confinement capabilities. Thus, the new method can be interpreted as a unification of the two methodologies, intended initially for different purposes.

  8. Genome editing: a robust technology for human stem cells.

    Science.gov (United States)

    Chandrasekaran, Arun Pandian; Song, Minjung; Ramakrishna, Suresh

    2017-09-01

    Human pluripotent stem cells comprise induced pluripotent and embryonic stem cells, which have tremendous potential for biological and therapeutic applications. The development of efficient technologies for the targeted genome alteration of stem cells in disease models is a prerequisite for utilizing stem cells to their full potential. Genome editing of stem cells is possible with the help of synthetic nucleases that facilitate site-specific modification of a gene of interest. Recent advances in genome editing techniques have improved the efficiency and speed of the development of stem cells for human disease models. Zinc finger nucleases, transcription activator-like effector nucleases, and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated system are powerful tools for editing DNA at specific loci. Here, we discuss recent technological advances in genome editing with site-specific nucleases in human stem cells.

  9. The Art of Electronics - 2nd Edition

    Science.gov (United States)

    Horowitz, Paul; Hill, Winfield

    1989-09-01

    This is the thoroughly revised and updated second edition of the hugely successful The Art of Electronics. Widely accepted as the single authoritative text and reference on electronic circuit design, both analog and digital, the original edition sold over 125,000 copies worldwide and was translated into eight languages. The book revolutionized the teaching of electronics by emphasizing the methods actually used by citcuit designers - a combination of some basic laws, rules to thumb, and a large nonmathematical treatment that encourages circuit values and performance. The new Art of Electronics retains the feeling of informality and easy access that helped make the first edition so successful and popular. It is an ideal first textbook on electronics for scientists and engineers and an indispensable reference for anyone, professional or amateur, who works with electronic circuits. The best self-teaching book and reference book in electronics Simply indispensable, packed with essential information for all scientists and engineers who build electronic circuits Totally rewritten chapters on microcomputers and microprocessors The first edition of this book has sold over 100,000 copies in seven years, it has a market in virtually all research centres where electronics is important

  10. Europe '92: Consequences of the European Unification for Cultural Federalism in the Federal Republic of Germany.

    Science.gov (United States)

    Berggreen, Ingeborg

    1990-01-01

    Discusses consequences of European unification in the Federal Republic of Germany. Focuses on the relationships between the European Community, the federal government of Germany, and the German states. Suggests that the German states are aware of their responsibility to give education and culture a European dimension. (NL)

  11. Desktop Access to Full-Text NACA and NASA Reports: Systems Developed by NASA Langley Technical Library

    Science.gov (United States)

    Ambur, Manjula Y.; Adams, David L.; Trinidad, P. Paul

    1997-01-01

    NASA Langley Technical Library has been involved in developing systems for full-text information delivery of NACA/NASA technical reports since 1991. This paper will describe the two prototypes it has developed and the present production system configuration. The prototype systems are a NACA CD-ROM of thirty-three classic paper NACA reports and a network-based Full-text Electronic Reports Documents System (FEDS) constructed from both paper and electronic formats of NACA and NASA reports. The production system is the DigiDoc System (DIGItal Documents) presently being developed based on the experiences gained from the two prototypes. DigiDoc configuration integrates the on-line catalog database World Wide Web interface and PDF technology to provide a powerful and flexible search and retrieval system. It describes in detail significant achievements and lessons learned in terms of data conversion, storage technologies, full-text searching and retrieval, and image databases. The conclusions from the experiences of digitization and full- text access and future plans for DigiDoc system implementation are discussed.

  12. Extractive text summarization system to aid data extraction from full text in systematic review development.

    Science.gov (United States)

    Bui, Duy Duc An; Del Fiol, Guilherme; Hurdle, John F; Jonnalagadda, Siddhartha

    2016-12-01

    Extracting data from publication reports is a standard process in systematic review (SR) development. However, the data extraction process still relies too much on manual effort which is slow, costly, and subject to human error. In this study, we developed a text summarization system aimed at enhancing productivity and reducing errors in the traditional data extraction process. We developed a computer system that used machine learning and natural language processing approaches to automatically generate summaries of full-text scientific publications. The summaries at the sentence and fragment levels were evaluated in finding common clinical SR data elements such as sample size, group size, and PICO values. We compared the computer-generated summaries with human written summaries (title and abstract) in terms of the presence of necessary information for the data extraction as presented in the Cochrane review's study characteristics tables. At the sentence level, the computer-generated summaries covered more information than humans do for systematic reviews (recall 91.2% vs. 83.8%, p<0.001). They also had a better density of relevant sentences (precision 59% vs. 39%, p<0.001). At the fragment level, the ensemble approach combining rule-based, concept mapping, and dictionary-based methods performed better than individual methods alone, achieving an 84.7% F-measure. Computer-generated summaries are potential alternative information sources for data extraction in systematic review development. Machine learning and natural language processing are promising approaches to the development of such an extractive summarization system. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Mojo Hand, a TALEN design tool for genome editing applications

    Directory of Open Access Journals (Sweden)

    Neff Kevin L

    2013-01-01

    Full Text Available Abstract Background Recent studies of transcription activator-like (TAL effector domains fused to nucleases (TALENs demonstrate enormous potential for genome editing. Effective design of TALENs requires a combination of selecting appropriate genetic features, finding pairs of binding sites based on a consensus sequence, and, in some cases, identifying endogenous restriction sites for downstream molecular genetic applications. Results We present the web-based program Mojo Hand for designing TAL and TALEN constructs for genome editing applications (http://www.talendesign.org. We describe the algorithm and its implementation. The features of Mojo Hand include (1 automatic download of genomic data from the National Center for Biotechnology Information, (2 analysis of any DNA sequence to reveal pairs of binding sites based on a user-defined template, (3 selection of restriction-enzyme recognition sites in the spacer between the TAL monomer binding sites including options for the selection of restriction enzyme suppliers, and (4 output files designed for subsequent TALEN construction using the Golden Gate assembly method. Conclusions Mojo Hand enables the rapid identification of TAL binding sites for use in TALEN design. The assembly of TALEN constructs, is also simplified by using the TAL-site prediction program in conjunction with a spreadsheet management aid of reagent concentrations and TALEN formulation. Mojo Hand enables scientists to more rapidly deploy TALENs for genome editing applications.

  14. RED: A Java-MySQL Software for Identifying and Visualizing RNA Editing Sites Using Rule-Based and Statistical Filters.

    Directory of Open Access Journals (Sweden)

    Yongmei Sun

    Full Text Available RNA editing is one of the post- or co-transcriptional processes that can lead to amino acid substitutions in protein sequences, alternative pre-mRNA splicing, and changes in gene expression levels. Although several methods have been suggested to identify RNA editing sites, there remains challenges to be addressed in distinguishing true RNA editing sites from its counterparts on genome and technical artifacts. In addition, there lacks a software framework to identify and visualize potential RNA editing sites. Here, we presented a software - 'RED' (RNA Editing sites Detector - for the identification of RNA editing sites by integrating multiple rule-based and statistical filters. The potential RNA editing sites can be visualized at the genome and the site levels by graphical user interface (GUI. To improve performance, we used MySQL database management system (DBMS for high-throughput data storage and query. We demonstrated the validity and utility of RED by identifying the presence and absence of C→U RNA-editing sites experimentally validated, in comparison with REDItools, a command line tool to perform high-throughput investigation of RNA editing. In an analysis of a sample data-set with 28 experimentally validated C→U RNA editing sites, RED had sensitivity and specificity of 0.64 and 0.5. In comparison, REDItools had a better sensitivity (0.75 but similar specificity (0.5. RED is an easy-to-use, platform-independent Java-based software, and can be applied to RNA-seq data without or with DNA sequencing data. The package is freely available under the GPLv3 license at http://github.com/REDetector/RED or https://sourceforge.net/projects/redetector.

  15. Leptoquark mechanism of neutrino masses within the grand unification framework

    Science.gov (United States)

    Doršner, Ilja; Fajfer, Svjetlana; Košnik, Nejc

    2017-06-01

    We demonstrate the viability of the one-loop neutrino mass mechanism within the framework of grand unification when the loop particles comprise scalar leptoquarks (LQs) and quarks of the matching electric charge. This mechanism can be implemented in both supersymmetric and non-supersymmetric models and requires the presence of at least one LQ pair. The appropriate pairs for the neutrino mass generation via the up-type and down-type quark loops are S_3-R_2 and S_{1, 3}-\\tilde{R}_2, respectively. We consider two distinct regimes for the LQ masses in our analysis. The first regime calls for very heavy LQs in the loop. It can be naturally realized with the S_{1, 3}-\\tilde{R}_2 scenarios when the LQ masses are roughly between 10^{12} and 5 × 10^{13} GeV. These lower and upper bounds originate from experimental limits on partial proton decay lifetimes and perturbativity constraints, respectively. Second regime corresponds to the collider accessible LQs in the neutrino mass loop. That option is viable for the S_3-\\tilde{R}_2 scenario in the models of unification that we discuss. If one furthermore assumes the presence of the type II see-saw mechanism there is an additional contribution from the S_3-R_2 scenario that needs to be taken into account beside the type II see-saw contribution itself. We provide a complete list of renormalizable operators that yield necessary mixing of all aforementioned LQ pairs using the language of SU(5). We furthermore discuss several possible embeddings of this mechanism in SU(5) and SO(10) gauge groups.

  16. Leptoquark mechanism of neutrino masses within the grand unification framework

    Energy Technology Data Exchange (ETDEWEB)

    Dorsner, Ilja [University of Split, Faculty of Electrical Engineering, Mechanical Engineering and Naval Architecture in Split (FESB), Split (Croatia); Fajfer, Svjetlana; Kosnik, Nejc [University of Ljubljana, Department of Physics, Ljubljana (Slovenia); Jozef Stefan Institute, Jamova 39, P. O. Box 3000, Ljubljana (Slovenia)

    2017-06-15

    We demonstrate the viability of the one-loop neutrino mass mechanism within the framework of grand unification when the loop particles comprise scalar leptoquarks (LQs) and quarks of the matching electric charge. This mechanism can be implemented in both supersymmetric and non-supersymmetric models and requires the presence of at least one LQ pair. The appropriate pairs for the neutrino mass generation via the up-type and down-type quark loops are S{sub 3}-R{sub 2} and S{sub 1,3}-R{sub 2}, respectively. We consider two distinct regimes for the LQ masses in our analysis. The first regime calls for very heavy LQs in the loop. It can be naturally realized with the S{sub 1,3}-R{sub 2} scenarios when the LQ masses are roughly between 10{sup 12} and 5 x 10{sup 13} GeV. These lower and upper bounds originate from experimental limits on partial proton decay lifetimes and perturbativity constraints, respectively. Second regime corresponds to the collider accessible LQs in the neutrino mass loop. That option is viable for the S{sub 3}-R{sub 2} scenario in the models of unification that we discuss. If one furthermore assumes the presence of the type II see-saw mechanism there is an additional contribution from the S{sub 3}-R{sub 2} scenario that needs to be taken into account beside the type II see-saw contribution itself. We provide a complete list of renormalizable operators that yield necessary mixing of all aforementioned LQ pairs using the language of SU(5). We furthermore discuss several possible embeddings of this mechanism in SU(5) and SO(10) gauge groups. (orig.)

  17. Cognitive Psychology and Instruction. Third Edition.

    Science.gov (United States)

    Bruning, Roger H.; Schraw, Gregory J.; Ronning, Royce R.

    Like the earlier editions, the current text is directed at educators who are interested in understanding the principles of cognitive psychology and applying them to instruction and curriculum design. The following chapters are included: (1) "Introduction to Cognitive Psychology"; (2) "Sensory, Short-Term, and Working Memory"; (3) "Long-Term…

  18. Thomas Jefferson, I dilemmi della democrazia americana, translated and edited by Alberto Giordano, with a preface by Dino Cofrancesco (Novi Ligure: Città del Silenzio, 2007

    Directory of Open Access Journals (Sweden)

    Pierluigi Chiassoni

    2010-03-01

    Full Text Available A review of Thomas Jefferson, I dilemmi della democrazia americana, translated and edited by Alberto Giordano, with a preface by Dino Cofrancesco (Novi Ligure: Città del Silenzio, 2007

  19. Full Text Searching and Customization in the NASA ADS Abstract Service

    Science.gov (United States)

    Eichhorn, G.; Accomazzi, A.; Grant, C. S.; Kurtz, M. J.; Henneken, E. A.; Thompson, D. M.; Murray, S. S.

    2004-01-01

    The NASA-ADS Abstract Service provides a sophisticated search capability for the literature in Astronomy, Planetary Sciences, Physics/Geophysics, and Space Instrumentation. The ADS is funded by NASA and access to the ADS services is free to anybody worldwide without restrictions. It allows the user to search the literature by author, title, and abstract text. The ADS database contains over 3.6 million references, with 965,000 in the Astronomy/Planetary Sciences database, and 1.6 million in the Physics/Geophysics database. 2/3 of the records have full abstracts, the rest are table of contents entries (titles and author lists only). The coverage for the Astronomy literature is better than 95% from 1975. Before that we cover all major journals and many smaller ones. Most of the journal literature is covered back to volume 1. We now get abstracts on a regular basis from most journals. Over the last year we have entered basically all conference proceedings tables of contents that are available at the Harvard Smithsonian Center for Astrophysics library. This has greatly increased the coverage of conference proceedings in the ADS. The ADS also covers the ArXiv Preprints. We download these preprints every night and index all the preprints. They can be searched either together with the other abstracts or separately. There are currently about 260,000 preprints in that database. In January 2004 we have introduced two new services, full text searching and a personal notification service called "myADS". As all other ADS services, these are free to use for anybody.

  20. Re-editing the paradigm of Cytidine (C) to Uridine (U) RNA editing.

    Science.gov (United States)

    Fossat, Nicolas; Tam, Patrick P L

    2014-01-01

    Cytidine (C) to Uridine (U) RNA editing is a post-trancriptional modification that until recently was known to only affect Apolipoprotein b (Apob) RNA and minimally require 2 components of the C to U editosome, the deaminase APOBEC1 and the RNA-binding protein A1CF. Our latest work has identified a novel RNA-binding protein, RBM47, as a core component of the editosome, which can substitute A1CF for the editing of ApoB mRNA. In addition, new RNA species that are subjected to C to U editing have been identified. Here, we highlight these recent discoveries and discuss how they change our view of the composition of the C to U editing machinery and expand our knowledge of the functional attributes of C to U RNA editing.

  1. William Gowers: the never completed third edition of the 'Bible of Neurology'.

    Science.gov (United States)

    Eadie, Mervyn J; Scott, Ann E M; Lees, Andrew J; Woodward, Martin

    2012-10-01

    William Gowers' classic single-authored two-volume A manual of diseases of the nervous system appeared in a first edition in 1886 and 1888, and in a second edition in 1892 and 1893, with a third edition of Volume 1 in 1899. No third edition of Volume 2 ever appeared. However, in 1949 Critchley stated that he had seen part of a revision of this volume. Subsequent writers could not find this material, but it recently came to light at Gowers' old hospital at Queen Square, London. The present paper describes the rediscovered material, containing Gowers' handwritten alterations for a further edition of Volume 2, and substantial new material, at least in relation to nystagmus and myasthenia. Gowers' declining health, or a conflict between his planned new text and his contributions to the neurology segments (1899) of Allbutt's System of medicine, may explain why a third edition of Volume 2 of the Manual of diseases of the nervous system never appeared.

  2. Towards an Editable, Versionized LOD Service for Library Data

    Directory of Open Access Journals (Sweden)

    Felix Ostrowski

    2013-02-01

    Full Text Available The Northrhine-Westphalian Library Service Center (hbz launched its LOD service lobid.org in August 2010 and has since then continuously been improving the underlying conversion processes, data models and software. The present paper first explains the background and motivation for developing lobid.org . It then describes the underlying software framework Phresnel which is written in PHP and which provides presentation and editing capabilities of RDF data based on the Fresnel Display Vocabulary for RDF. The paper gives an overview of the current state of the Phresnel development and discusses the technical challenges encountered. Finally, possible prospects for further developing Phresnel are outlined.

  3. Evolutionary reversion of editing sites of ndh genes suggests their origin in the Permian-Triassic, before the increase of atmospheric CO2

    Directory of Open Access Journals (Sweden)

    Mercedes eMartin

    2015-07-01

    Full Text Available The plastid ndh genes have hovered frequently on the edge of dispensability. They are absent in the plastid DNA of many algae and certain higher plants and present editing sites requiring C-to-U corrections of primary transcripts. The evolutionary origin of editing sites and their loss due to C-to-T reversions at the DNA level are unknown and must be related to the dispensability of the ndh genes in specific environments. In order to better understand the evolution of ndh gene editing sites, we have created expandable data banks with the 12 editing sites of the ndhB gene (600 GenBank sequences and both editing sites of the ndhF gene (1,600 GenBank sequences. Since their origin via T-to-C mutations that probably occurred between 300 and 200 Myr BP (Permian-Triassic, ndh editing sites have undergone independent and random C-to-T reversions in the different angiosperm lineages. Some of these reversions appear early in angiosperm diversification. Old C-to-T reversions can be traced back to radiation steps that gave origin to main classes, orders and some families.

  4. The structural and content aspects of abstracts versus bodies of full text journal articles are different.

    Science.gov (United States)

    Cohen, K Bretonnel; Johnson, Helen L; Verspoor, Karin; Roeder, Christophe; Hunter, Lawrence E

    2010-09-29

    An increase in work on the full text of journal articles and the growth of PubMedCentral have the opportunity to create a major paradigm shift in how biomedical text mining is done. However, until now there has been no comprehensive characterization of how the bodies of full text journal articles differ from the abstracts that until now have been the subject of most biomedical text mining research. We examined the structural and linguistic aspects of abstracts and bodies of full text articles, the performance of text mining tools on both, and the distribution of a variety of semantic classes of named entities between them. We found marked structural differences, with longer sentences in the article bodies and much heavier use of parenthesized material in the bodies than in the abstracts. We found content differences with respect to linguistic features. Three out of four of the linguistic features that we examined were statistically significantly differently distributed between the two genres. We also found content differences with respect to the distribution of semantic features. There were significantly different densities per thousand words for three out of four semantic classes, and clear differences in the extent to which they appeared in the two genres. With respect to the performance of text mining tools, we found that a mutation finder performed equally well in both genres, but that a wide variety of gene mention systems performed much worse on article bodies than they did on abstracts. POS tagging was also more accurate in abstracts than in article bodies. Aspects of structure and content differ markedly between article abstracts and article bodies. A number of these differences may pose problems as the text mining field moves more into the area of processing full-text articles. However, these differences also present a number of opportunities for the extraction of data types, particularly that found in parenthesized text, that is present in article bodies

  5. Ebola virus RNA editing depends on the primary editing site sequence and an upstream secondary structure.

    Science.gov (United States)

    Mehedi, Masfique; Hoenen, Thomas; Robertson, Shelly; Ricklefs, Stacy; Dolan, Michael A; Taylor, Travis; Falzarano, Darryl; Ebihara, Hideki; Porcella, Stephen F; Feldmann, Heinz

    2013-01-01

    Ebolavirus (EBOV), the causative agent of a severe hemorrhagic fever and a biosafety level 4 pathogen, increases its genome coding capacity by producing multiple transcripts encoding for structural and nonstructural glycoproteins from a single gene. This is achieved through RNA editing, during which non-template adenosine residues are incorporated into the EBOV mRNAs at an editing site encoding for 7 adenosine residues. However, the mechanism of EBOV RNA editing is currently not understood. In this study, we report for the first time that minigenomes containing the glycoprotein gene editing site can undergo RNA editing, thereby eliminating the requirement for a biosafety level 4 laboratory to study EBOV RNA editing. Using a newly developed dual-reporter minigenome, we have characterized the mechanism of EBOV RNA editing, and have identified cis-acting sequences that are required for editing, located between 9 nt upstream and 9 nt downstream of the editing site. Moreover, we show that a secondary structure in the upstream cis-acting sequence plays an important role in RNA editing. EBOV RNA editing is glycoprotein gene-specific, as a stretch encoding for 7 adenosine residues located in the viral polymerase gene did not serve as an editing site, most likely due to an absence of the necessary cis-acting sequences. Finally, the EBOV protein VP30 was identified as a trans-acting factor for RNA editing, constituting a novel function for this protein. Overall, our results provide novel insights into the RNA editing mechanism of EBOV, further understanding of which might result in novel intervention strategies against this viral pathogen.

  6. Designing Multimodal Mobile Interaction for a Text Messaging Application for Visually Impaired Users

    Directory of Open Access Journals (Sweden)

    Carlos Duarte

    2017-12-01

    Full Text Available While mobile devices have experienced important accessibility advances in the past years, people with visual impairments still face important barriers, especially in specific contexts when both their hands are not free to hold the mobile device, like when walking outside. By resorting to a multimodal combination of body based gestures and voice, we aim to achieve full hands and vision free interaction with mobile devices. In this article, we describe this vision and present the design of a prototype, inspired by that vision, of a text messaging application. The article also presents a user study where the suitability of the proposed approach was assessed, and a performance comparison between our prototype and existing SMS applications was conducted. Study participants received positively the prototype, which also supported better performance in tasks that involved text editing.

  7. Readying Cavalli's operas for the classroom: textbooks, editions, and the teaching of a non-canonic composer

    Directory of Open Access Journals (Sweden)

    Robert Holzer

    2014-12-01

    Full Text Available My title pays homage to a recent volume of essays edited by Ellen Rosand and devoted to the scholarship and performance of Francesco Cavalli’s operas. Yet if love of wordplay inspired it, coincidence confirmed it. The volume appeared in print just months after my own foray into editing, albeit of a very different kind. I had been asked to prepare one of the volumes of The Oxford Anthology of Western Music, specifically the part that deals with Baroque music. As its title suggests, the anthology accompanies The Oxford History of Western Music: College Edition, the one-volume abridgement of Richard Taruskin’s five-volume behemoth prepared by Christopher H. Gibbs. I was charged with assembling scores of the works discussed therein and writing commentary on them, based on Taruskin’s own in the larger text. While I was left free to do as I pleased with the latter, such was not the case with the former. Thus music after 1700 occupies more pages than that before 1700, and the earlier repertory features some notable lacunae. That one of the biggest is Francesco Cavalli comes as no surprise, for in the course of the more than 3,800 pages of Taruskin’s original the composer receives exactly three sentences.

  8. Understanding Editing Behaviors in Multilingual Wikipedia.

    Science.gov (United States)

    Kim, Suin; Park, Sungjoon; Hale, Scott A; Kim, Sooyoung; Byun, Jeongmin; Oh, Alice H

    2016-01-01

    Multilingualism is common offline, but we have a more limited understanding of the ways multilingualism is displayed online and the roles that multilinguals play in the spread of content between speakers of different languages. We take a computational approach to studying multilingualism using one of the largest user-generated content platforms, Wikipedia. We study multilingualism by collecting and analyzing a large dataset of the content written by multilingual editors of the English, German, and Spanish editions of Wikipedia. This dataset contains over two million paragraphs edited by over 15,000 multilingual users from July 8 to August 9, 2013. We analyze these multilingual editors in terms of their engagement, interests, and language proficiency in their primary and non-primary (secondary) languages and find that the English edition of Wikipedia displays different dynamics from the Spanish and German editions. Users primarily editing the Spanish and German editions make more complex edits than users who edit these editions as a second language. In contrast, users editing the English edition as a second language make edits that are just as complex as the edits by users who primarily edit the English edition. In this way, English serves a special role bringing together content written by multilinguals from many language editions. Nonetheless, language remains a formidable hurdle to the spread of content: we find evidence for a complexity barrier whereby editors are less likely to edit complex content in a second language. In addition, we find that multilinguals are less engaged and show lower levels of language proficiency in their second languages. We also examine the topical interests of multilingual editors and find that there is no significant difference between primary and non-primary editors in each language.

  9. New fat Higgs: Increasing the MSSM Higgs mass with natural gauge unification

    International Nuclear Information System (INIS)

    Chang, Spencer; Kilic, Can; Mahbubani, Rakhi

    2005-01-01

    In this paper we increase the minimal supersymmetric standard model tree level Higgs mass bound to a value that is naturally larger than the LEP-II search constraint by adding to the superpotential a λSH u H d term, as in the next to minimal supersymmetric standard model, and UV completing with new strong dynamics before λ becomes nonperturbative. Unlike other models of this type, the Higgs fields remain elementary, alleviating the supersymmetric fine-tuning problem while maintaining unification in a natural way

  10. Careers and retention of staff in the 21st century world of work: Introduction to the special edition

    Directory of Open Access Journals (Sweden)

    Melinde Coetzee

    2012-12-01

    Full Text Available How to cite this article: Coetzee, M., & Gunz, H. (2012. Careers and retention of staff in the 21st century world of work: Introduction to the special edition. SA Journal of Human Resource Management/SA Tydskrif vir Menslikehulpbronbestuur, 10(2, Art. #505, 4 pages. http://dx.doi.org/10.4102/ sajhrm.v10i2.505

  11. Editor's intervention in the register of compounds in archaic Portuguese texts: some reflections on the use of hyphen

    Directory of Open Access Journals (Sweden)

    Antonia Vieira dos Santos

    2014-07-01

    Full Text Available The use of hyphen within compounds was not built up before the nineteenth century. Thus, compounds spelled with hyphen in archaic Portuguese texts are a result of editing criteria adopted by editors. From this type of intervention, the relationship between hyphen use – result of a spelling convention – and the definition of compound adopted by the editor are discussed. Its absence is significant to the history of the language.

  12. Full-text publication of abstracts presented at European Orthodontic Society congresses.

    Science.gov (United States)

    Livas, Christos; Pandis, Nikolaos; Ren, Yijin

    2014-10-01

    Empirical evidence has indicated that only a subsample of studies conducted reach full-text publication and this phenomenon has become known as publication bias. A form of publication bias is the selectively delayed full publication of conference abstracts. The objective of this article was to examine the publication status of oral abstracts and poster-presentation abstracts, included in the scientific program of the 82nd and 83rd European Orthodontic Society (EOS) congresses, held in 2006 and 2007, and to identify factors associated with full-length publication. A systematic search of PubMed and Google Scholar databases was performed in April 2013 using author names and keywords from the abstract title to locate abstract and full-article publications. Information regarding mode of presentation, type of affiliation, geographical origin, statistical results, and publication details were collected and analyzed using univariable and multivariable logistic regression. Approximately 51 per cent of the EOS 2006 and 55 per cent of the EOS 2007 abstracts appeared in print more than 5 years post congress. A mean period of 1.32 years elapsed between conference and publication date. Mode of presentation (oral or poster), use of statistical analysis, and research subject area were significant predictors for publication success. Inherent discrepancies of abstract reporting, mainly related to presentation of preliminary results and incomplete description of methods, may be considered in analogous studies. On average 52.2 per cent of the abstracts presented at the two EOS conferences reached full publication. Abstracts presented orally, including statistical analysis, were more likely to get published. © The Author 2013. Published by Oxford University Press on behalf of the European Orthodontic Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  13. The Monthly Sky Guide: Sixth Edition

    Science.gov (United States)

    Ridpath, Ian; Tirion, Wil

    2003-06-01

    The latest edition of Ian Ridpath and Wil Tirion's popular guide to the night sky is updated for planet positions and forthcoming eclipses up to the end of the year 2007. With one chapter for each month of the year, this is an easy-to-use handbook for anyone wanting to identify constellations, star clusters, nebulae, to plot the movement of planets, or witness solar and lunar eclipses. Most of the features discussed are visible to the naked eye and all can be seen with a small telescope or binoculars. Ian Ridpath has been a full-time writer, broadcaster and lecturer on astronomy and space for more than twenty-five years. He has written and edited more than 40 books, including A Comet Called Haley (Cambridge, 1985). Wil Tirion made his first star map in 1977. It showed stars to the magnitude of 6.5 and was issued as a set of maps by the British Astronomical Association in 1981. He has illustrated numerous books and magazines, including The Cambridge Star Atlas (Cambridge, 2001). Previous Edition Pb (1999): 0-521-66771-2

  14. REDIdb: the RNA editing database.

    Science.gov (United States)

    Picardi, Ernesto; Regina, Teresa Maria Rosaria; Brennicke, Axel; Quagliariello, Carla

    2007-01-01

    The RNA Editing Database (REDIdb) is an interactive, web-based database created and designed with the aim to allocate RNA editing events such as substitutions, insertions and deletions occurring in a wide range of organisms. The database contains both fully and partially sequenced DNA molecules for which editing information is available either by experimental inspection (in vitro) or by computational detection (in silico). Each record of REDIdb is organized in a specific flat-file containing a description of the main characteristics of the entry, a feature table with the editing events and related details and a sequence zone with both the genomic sequence and the corresponding edited transcript. REDIdb is a relational database in which the browsing and identification of editing sites has been simplified by means of two facilities to either graphically display genomic or cDNA sequences or to show the corresponding alignment. In both cases, all editing sites are highlighted in colour and their relative positions are detailed by mousing over. New editing positions can be directly submitted to REDIdb after a user-specific registration to obtain authorized secure access. This first version of REDIdb database stores 9964 editing events and can be freely queried at http://biologia.unical.it/py_script/search.html.

  15. An optimized electroporation approach for efficient CRISPR/Cas9 genome editing in murine zygotes.

    Directory of Open Access Journals (Sweden)

    Simon E Tröder

    Full Text Available Electroporation of zygotes represents a rapid alternative to the elaborate pronuclear injection procedure for CRISPR/Cas9-mediated genome editing in mice. However, current protocols for electroporation either require the investment in specialized electroporators or corrosive pre-treatment of zygotes which compromises embryo viability. Here, we describe an easily adaptable approach for the introduction of specific mutations in C57BL/6 mice by electroporation of intact zygotes using a common electroporator with synthetic CRISPR/Cas9 components and minimal technical requirement. Direct comparison to conventional pronuclear injection demonstrates significantly reduced physical damage and thus improved embryo development with successful genome editing in up to 100% of living offspring. Hence, our novel approach for Easy Electroporation of Zygotes (EEZy allows highly efficient generation of CRISPR/Cas9 transgenic mice while reducing the numbers of animals required.

  16. Childhood re-edits: challenging norms and forming lay professional competence on YouTube

    Directory of Open Access Journals (Sweden)

    Konstantin Economou

    2015-12-01

    Full Text Available This article presents the initial findings of research into how YouTube culture can become an arena for young YouTube videographers to remodel mainstream, sub-cultural, and media content (YouTube clips, music, film content, and viral memes. We juxtapose analyses from both media and child studies to look at the ways in which preferred images and notions of the “good” and idyllic childhood are re-edited into a possible critique of the prescribed Swedish childhood. Also, we look at ways in which these media-literate actors use YouTube to display their skills in both media editing and social media “savvy.” We discuss how “lay” professional competence in digital culture can be inherent in a friction between popular (children's culture and social media production, where simultaneous prowess in both is important for how a mediatised social and cultural critique can emerge.

  17. Observing Optional Number in DDC Edition 23

    Directory of Open Access Journals (Sweden)

    Mohamad Rotmianto

    2015-04-01

    Full Text Available Dewey Decimal Classification is a most popular classification system in the world because of its completeness and most up-to-date. There are many optional number in this classification system, although it rarely to be discussed even it is important to known well about that optional number, especially  for  a  librarian  as  classifier.  This  paper  is  a  literature  study  about  Dewey  Decimal Classification  Edition  23,  to  describe  about  optional  numbers,  particularly  the  number  in relationship with Indonesia’s subject and discipline. This paper is to avoid misunderstanding in interpreted about optional number among librarians, especially for who that does not understand well about optional numbers.

  18. Writing, Proofreading and Editing in Information Theory

    Directory of Open Access Journals (Sweden)

    J. Ricardo Arias-Gonzalez

    2018-05-01

    Full Text Available Information is a physical entity amenable to be described by an abstract theory. The concepts associated with the creation and post-processing of the information have not, however, been mathematically established, despite being broadly used in many fields of knowledge. Here, inspired by how information is managed in biomolecular systems, we introduce writing, entailing any bit string generation, and revision, as comprising proofreading and editing, in information chains. Our formalism expands the thermodynamic analysis of stochastic chains made up of material subunits to abstract strings of symbols. We introduce a non-Markovian treatment of operational rules over the symbols of the chain that parallels the physical interactions responsible for memory effects in material chains. Our theory underlies any communication system, ranging from human languages and computer science to gene evolution.

  19. From Minimal to Realistic Supersymmetric SU(5) Grand Unification

    CERN Document Server

    Altarelli, Guido; Masina, I; Altarelli, Guido; Feruglio, Ferruccio; Masina, Isabella

    2000-01-01

    We construct and discuss a "realistic" example of SUSY SU(5) GUT model, with an additional U(1) flavour symmetry, that is not plagued by the need of large fine tunings, like those associated with doublet-triplet splitting in the minimal model, and that leads to an acceptable phenomenology. This includes coupling unification with a value of alpha_s(m_Z) in much better agreement with the data than in the minimal version, an acceptable hierarchical pattern for fermion masses and mixing angles, also including neutrino masses and mixings, and a proton decay rate compatible with present limits (but the discovery of proton decay should be within reach of the next generation of experiments). In the neutrino sector the preferred solution is one with nearly maximal mixing both for atmospheric and solar neutrinos.

  20. Grand unification and the fundamental problems of classical cosmology

    International Nuclear Information System (INIS)

    Turner, M.S.

    1981-01-01

    The accomplishments of classical cosmology are reviewed. In particular, the hot big bang model provides a reliable framework for understanding the evolution of the universe back to times at least as early as approx. 0.01 s after the big bang. At present there are (at least) six fundamental problems which have not yet been (completely) resolved. They are: (1) the origin of the baryon number-to-entropy ratio, (2) the origin of the isotropy, (3) the origin of the homogeneity and inhomogeneity, (4) the origin of the flatness, (5) the cosmological constant, and (6) the monopole problem. The role that grand unification has played, and may play in the resolution of these puzzles is discussed. Guth's inflationary universe, which addresses five of these six problems, is reviewed

  1. Alternative splicing and extensive RNA editing of human TPH2 transcripts.

    Directory of Open Access Journals (Sweden)

    Maik Grohmann

    Full Text Available Brain serotonin (5-HT neurotransmission plays a key role in the regulation of mood and has been implicated in a variety of neuropsychiatric conditions. Tryptophan hydroxylase (TPH is the rate-limiting enzyme in the biosynthesis of 5-HT. Recently, we discovered a second TPH isoform (TPH2 in vertebrates, including man, which is predominantly expressed in brain, while the previously known TPH isoform (TPH1 is primarly a non-neuronal enzyme. Overwhelming evidence now points to TPH2 as a candidate gene for 5-HT-related psychiatric disorders. To assess the role of TPH2 gene variability in the etiology of psychiatric diseases we performed cDNA sequence analysis of TPH2 transcripts from human post mortem amygdala samples obtained from individuals with psychiatric disorders (drug abuse, schizophrenia, suicide and controls. Here we show that TPH2 exists in two alternatively spliced variants in the coding region, denoted TPH2a and TPH2b. Moreover, we found evidence that the pre-mRNAs of both splice variants are dynamically RNA-edited in a mutually exclusive manner. Kinetic studies with cell lines expressing recombinant TPH2 variants revealed a higher activity of the novel TPH2B protein compared with the previously known TPH2A, whereas RNA editing was shown to inhibit the enzymatic activity of both TPH2 splice variants. Therefore, our results strongly suggest a complex fine-tuning of central nervous system 5-HT biosynthesis by TPH2 alternative splicing and RNA editing. Finally, we present molecular and large-scale linkage data evidencing that deregulated alternative splicing and RNA editing is involved in the etiology of psychiatric diseases, such as suicidal behaviour.

  2. Playing at bullying: The postmodern ethic of Bully (Canis Canem Edit

    Directory of Open Access Journals (Sweden)

    Clare Bradford

    2009-05-01

    Full Text Available This essay discusses Bully (Canis Canem Edit, considering the game’s antecedents (narratives involving young people in school settings and the features which set it apart from other teen texts. It discusses the controversy surrounding the game and comes to the conclusion that the principal reason for unease on the part of parents and educational authorities is that Bully’s postmodernist ethic evades the binaries of liberal humanism and calls into question the foundations on which conventional ethical systems are based. The paper considers several episodes from the game to flesh out its arguments about how the game manifests features of postmodernist textuality in its propensity for simultaneously deploying and interrogating references to historical and contemporary cultural practices.

  3. Cloud Properties of CERES-MODIS Edition 4 and CERES-VIIRS Edition 1

    Science.gov (United States)

    Sun-Mack, Sunny; Minnis, Patrick; Chang, Fu-Lung; Hong, Gang; Arduini, Robert; Chen, Yan; Trepte, Qing; Yost, Chris; Smith, Rita; Brown, Ricky; hide

    2015-01-01

    The Clouds and Earth's Radiant Energy System (CERES) analyzes MODerate-resolution Imaging Spectroradiometer (MODIS) data and Visible Infrared Imaging Radiometer Suite (VIIRS) to derive cloud properties that are combine with aerosol and CERES broadband flux data to create a multi-parameter data set for climate study. CERES has produced over 15 years of data from Terra and over 13 years of data from Aqua using the CERES-MODIS Edition-2 cloud retrieval algorithm. A recently revised algorithm, CERESMODIS Edition 4, has been developed and is now generating enhanced cloud data for climate research (over 10 years for Terra and 8 years for Aqua). New multispectral retrievals of properties are included along with a multilayer cloud retrieval system. Cloud microphysical properties are reported at 3 wavelengths, 0.65, 1.24, and 2.1 microns to enable better estimates of the vertical profiles of cloud water contents. Cloud properties over snow are retrieved using the 1.24-micron channel. A new CERES-VIIRS cloud retrieval package was developed for the VIIRS spectral complement and is currently producing the CERES-VIIRS Edition 1 cloud dataset. The results from CERES-MODIS Edition 4 and CERES-VIIRS Edition 1 are presented and compared with each other and other datasets, including CALIPSO, CloudSat and the CERES-MODIS Edition-2 results.

  4. Local grand unification in the heterotic landscape

    International Nuclear Information System (INIS)

    Schmidt, Jonas

    2009-06-01

    We consider the possibility that the unification of the electroweak interactions and the strong force arises from string theory, at energies significantly lower than the string scale. As a tool, an effective grand unified field theory in six dimensions is derived from an anisotropic orbifold compactification of the heterotic string. It is explicitly shown that all anomalies cancel in the model, though anomalous Abelian gauge symmetries are present locally at the boundary singularities. In the supersymmetric vacuum additional interactions arise from higher-dimensional operators. We develop methods that relate the couplings of the effective theory to the location of the vacuum, and find that unbroken discrete symmetries play an important role for the phenomenology of orbifold models. An efficient algorithm for the calculation of the superpotential to arbitrary order is developed, based on symmetry arguments. We furthermore present a correspondence between bulk fields of the orbifold model in six dimensions, and the moduli fields that arise from compactifying four internal dimensions on a manifold with non-trivial gauge background. (orig.)

  5. Local grand unification in the heterotic landscape

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, Jonas

    2009-07-15

    We consider the possibility that the unification of the electroweak interactions and the strong force arises from string theory, at energies significantly lower than the string scale. As a tool, an effective grand unified field theory in six dimensions is derived from an anisotropic orbifold compactification of the heterotic string. It is explicitly shown that all anomalies cancel in the model, though anomalous Abelian gauge symmetries are present locally at the boundary singularities. In the supersymmetric vacuum additional interactions arise from higher-dimensional operators. We develop methods that relate the couplings of the effective theory to the location of the vacuum, and find that unbroken discrete symmetries play an important role for the phenomenology of orbifold models. An efficient algorithm for the calculation of the superpotential to arbitrary order is developed, based on symmetry arguments. We furthermore present a correspondence between bulk fields of the orbifold model in six dimensions, and the moduli fields that arise from compactifying four internal dimensions on a manifold with non-trivial gauge background. (orig.)

  6. Yukawa sector of minimal SO(10) unification

    Energy Technology Data Exchange (ETDEWEB)

    Babu, K.S. [Department of Physics, Oklahoma State University,Stillwater, OK, 74078 (United States); Bajc, Borut [Jožef Stefan Institute,Ljubljana, 1000 (Slovenia); Saad, Shaikh [Department of Physics, Oklahoma State University,Stillwater, OK, 74078 (United States)

    2017-02-28

    We show that in SO(10) models, a Yukawa sector consisting of a real 10{sub H}, a real 120{sub H} and a complex 126{sub H} of Higgs fields can provide a realistic fit to all fermion masses and mixings, including the neutrino sector. Although the group theory of SO(10) demands that the 10{sub H} and 120{sub H} be real, most constructions complexify these fields and impose symmetries exterior to SO(10) to achieve predictivity. The proposed new framework with real10{sub H} and real120{sub H} relies only on SO(10) gauge symmetry, and yet has a limited number of Yukawa parameters. Our analysis shows that while there are restrictions on the observables, a good fit to the entire fermion spectrum can be realized. Unification of gauge couplings is achieved with an intermediate scale Pati-Salam gauge symmetry. Proton decay branching ratios are calculable, with the leading decay modes being p→ν̄π{sup +} and p→e{sup +}π{sup 0}.

  7. Supersymmetry and the unification of fundamental interactions.

    Science.gov (United States)

    Fayet, P.

    Les physiciens élaborent progressivement une description unifée des lois de l'Univers, qui fait intervenir des principes de symétrie de plus en plus étendus. La supersymétrie, qui englobe la mécanique quantique et la relativité générale en opérant dans une extension de l'espace-temps ordinaire, appelée le superespace, est-elle l'un de ces principes fondamentaux? Dans cet article, l'auteur explique ce qu'est cette nouvelle symétrie, et comment, pour appliquer celle-ci au monde physique, il a été amené à envisager l'existence de toute une famille de nouvelles particules - comme les photinos, gluinos, squarks et sélectrons - que l'on recherche activement aujourd'hui. On espère parvenir à les détecter grâce aux nouvelles générations d'accélerateurs, et découvrir ainsi un nouveau principe auquel doivent satisfaire toutes les lois physiques, aussi fondamental que la relativité.

  8. Commercial Database Design vs. Library Terminology Comprehension: Why Do Students Print Abstracts Instead of Full-Text Articles?

    Science.gov (United States)

    Imler, Bonnie; Eichelberger, Michelle

    2014-01-01

    When asked to print the full text of an article, many undergraduate college students print the abstract instead of the full text. This study seeks to determine the underlying cause(s) of this confusion. In this quantitative study, participants (n = 40) performed five usability tasks to assess ease of use and usefulness of five commercial library…

  9. The development of the idiomatic piano language through Clementi’s edition of D. Scarlatti’s sonatas (1791

    Directory of Open Access Journals (Sweden)

    Laura Cuervo Calvo

    2018-01-01

    Full Text Available Muzio Clementi edited the first known publication of Domenico Scarlatti´s sonatas for piano: Scarlatti’s Chefs d’Oeuvre, for the Harpsichord or Piano forte [1791]. This work contains ten Scarlatti´s sonatas selected by Clementi among some 18th- century manuscripts, one Antonio Soler sonata, and another anonymous one. The imnportance of this collection is that it made possible the diffusion of the Scarlatti’s sonatas Kk 378, 380, 490, 400, 475, 381, 206, 531, 462, 463, which only were accessible to a minority. Moreover, The musical text of Clementi´s edition varies considerably from most other manuscript sources. Studying the published reviews, it will be possible to contribute information about the interpretive practice of the key instruments about the end of the 18th century, about the characteristics of the English pianos for which Clementi realized the above mentioned review, and about the development of the idiomatic specific language of the piano in this epoch.

  10. Impact of Metadata on Full-text Information Retrieval Performance: An Experimental Research on a Small Scale Turkish Corpus

    Directory of Open Access Journals (Sweden)

    Çağdaş Çapkın

    2016-12-01

    Full Text Available Information institutions use text-based information retrieval systems to store, index and retrieve metadata, full-text, or both metadata and full-text (hybrid contents. The aim of this research was to evaluate impact of these contents on information retrieval performance. For this purpose, metadata (MIR, full-text (FIR and hybrid (HIR content information retrieval systems were developed with default Lucene information retrieval model for a small scale Turkish corpus. In order to evaluate performance of this three systems, “precision - recall” and “normalized recall” tests were conducted. Experimental findings showed that there were no significant differences between MIR and FIR in mean average precision (MAP performance. On the other hand, MAP performance of HIR was significantly higher in comparison to MIR and FIR. When information retrieval performance was evaluated as user-centered, the “normalized recall” performances of MIR and HIR were significantly higher than FIR. Additionally, there were no significant differences between the systems in retrieved relevant document means. Processing different types of contents such as metadata and full-text had some advantages and disadvantages for information retrieval systems in terms of term management. The advantages brought together in hybrid content processing (HIR and information retrieval performance improved.

  11. Genome editing in mouse spermatogonial stem/progenitor cells using engineered nucleases.

    Directory of Open Access Journals (Sweden)

    Danielle A Fanslow

    Full Text Available Editing the genome to create specific sequence modifications is a powerful way to study gene function and promises future applicability to gene therapy. Creation of precise modifications requires homologous recombination, a very rare event in most cell types that can be stimulated by introducing a double strand break near the target sequence. One method to create a double strand break in a particular sequence is with a custom designed nuclease. We used engineered nucleases to stimulate homologous recombination to correct a mutant gene in mouse "GS" (germline stem cells, testicular derived cell cultures containing spermatogonial stem cells and progenitor cells. We demonstrated that gene-corrected cells maintained several properties of spermatogonial stem/progenitor cells including the ability to colonize following testicular transplantation. This proof of concept for genome editing in GS cells impacts both cell therapy and basic research given the potential for GS cells to be propagated in vitro, contribute to the germline in vivo following testicular transplantation or become reprogrammed to pluripotency in vitro.

  12. Ten years after the unification : East Germany and the relevance of modern theories of trade, location and growth

    NARCIS (Netherlands)

    Brakman, S.; Schramm, M.; Garretsen, Harry

    2000-01-01

    In the paper we analyse, ten years after the German unification, the relevance of modern theoretical developments on trade, location and growth for East Germany using sectoral and regional data. Given our discussion of stylized facts about industry growth, economies of scale and differences in

  13. Bankruptcy and Voluntary Liquidation: Evidence for New Firms in East and West Germany after Unification

    OpenAIRE

    Prantl, Susanne

    2003-01-01

    Exploiting the unique economic situation after German unification, I investigate how exit decisions deviate between new firms in a transition and a comparatively stable market environment. Two competing exit mechanisms are considered: entrepreneurial self-selection via voluntary liquidation and external selection based on insolvency regulation. Distinguishing between the competing exit modes proves to be crucial in semi-parametric propor- tional hazard-rate estimations. Comparing East and Wes...

  14. FULIR Full-text Institutional Repository of the Ruđer Bošković Institute

    Directory of Open Access Journals (Sweden)

    Macan, B.

    2014-11-01

    Full Text Available Institutional repositories are online platforms for gathering, archiving, dissemination and long-term preservation of an institution’s scientific output. Archiving full-text papers into the institutional and other open access repositories (OAR is one way of achieving open access to scientific informa tion, the so-called “green” OA. In 2006 the idea of implementing an institutional repository at the Ruđer Bošković Institute Library was initiated and one year later, the project had started, parallel with the subproject of digitizing RBI’s documentary materials. 4 Various open source solutions were tested, among which EPrints software was chosen as the most suitable to RBI’s needs. The first documents were archived in March 2011, and on October 18, 2012, the official version of the repository was published under the name Full-text Institutional Repository of the Ruđer Bošković Institute – FULIR. The goal of FULIR is to gather, archive, disseminate and preserve, for the long term, the whole scientific production and documentary materials of the Institute in digital form, as well as provide open access to archived materials where possible. It is possible to archive all kinds of materials in FULIR, such as articles published in journals, conference proceedings, books, book chapters, dissertations, but also various kinds of unpublished materials such as posters and presentations from conferences or lectures, reports, audio and video records and datasets. FULIR is based on the principle that the scientists themselves archive their materials, but in this initial phase, the librarians are also assisting the scientists in archiving new items. The repository allows different access rights to archived materials and a depositor may define to whom (all users/only registered users (RBI staff/only repository administrators, and when (immediately or after a cer tain embargo period full-texts of archived materials will be available. Repository

  15. Electronic Warfare Target Location Methods, Second Edition. Edited by Richard A. Poisel, Artech House, 2012; 422 pages. Price: £99.00, ISBN 978-1-60807-523-2

    Directory of Open Access Journals (Sweden)

    Shu-Kun Lin

    2013-01-01

    Full Text Available Describing the mathematical development underlying current and classical methods of geolocating electronic systems that are emitting, this newly revised and greatly expanded edition of a classic Artech House book offers practical guidance in electronic warfare target location. The Second Edition features a wealth of additional material including new chapters on time delay estimation, direction finding techniques, and the MUSIC algorithm. This practical resource provides you with critical design information on geolocation algorithms, and establishes the fundamentals of existing algorithms as a launch point for further algorithm development. You gain an in-depth understanding of key target location methods that you can effectively apply to your work in the field. You discover triangulation algorithms that offer a highly efficient way to geolocate targets when the real estate on the sensor systems is adequate to support an antenna array. The book also presents quadratic geolocation techniques that can be implemented with extremely modest antennas — frequently a single dipole or monopole. Moreover, this authoritative volume details methods for geolocating the source of high frequency signals with a single sensor site.

  16. Dark matter as the signal of grand unification

    International Nuclear Information System (INIS)

    Kadastik, Mario; Kannike, Kristjan; Raidal, Martti

    2009-01-01

    We argue that the existence of dark matter (DM) is a possible consequence of grand unification (GUT) symmetry breaking. In GUTs like SO(10), discrete Z 2 matter parity (-1) 3(B-L) survives despite broken B-L, and group theory uniquely determines that the only possible Z 2 -odd matter multiplets belong to representation 16. We construct the minimal nonsupersymmetric SO(10) model containing one scalar 16 for DM and study its predictions below M G . We find that electroweak symmetry breaking occurs radiatively due to DM couplings to the standard model Higgs boson. For thermal relic DM the mass range M DM ∼O(0.1-1) TeV is predicted by model perturbativity up to M G . For M DM ∼O(1) TeV to explain the observed cosmic ray anomalies with DM decays, there exists a lower bound on the spin-independent direct detection cross section within the reach of planned experiments.

  17. REDEN: Named Entity Linking in Digital Literary Editions Using Linked Data Sets

    Directory of Open Access Journals (Sweden)

    Carmen Brando

    2016-07-01

    Full Text Available This paper proposes a graph-based Named Entity Linking (NEL algorithm named REDEN for the disambiguation of authors’ names in French literary criticism texts and scientific essays from the 19th and early 20th centuries. The algorithm is described and evaluated according to the two phases of NEL as reported in current state of the art, namely, candidate retrieval and candidate selection. REDEN leverages knowledge from different Linked Data sources in order to select candidates for each author mention, subsequently crawls data from other Linked Data sets using equivalence links (e.g., owl:sameAs, and, finally, fuses graphs of homologous individuals into a non-redundant graph well-suited for graph centrality calculation; the resulting graph is used for choosing the best referent. The REDEN algorithm is distributed in open-source and follows current standards in digital editions (TEI and semantic Web (RDF. Its integration into an editorial workflow of digital editions in Digital humanities and cultural heritage projects is entirely plausible. Experiments are conducted along with the corresponding error analysis in order to test our approach and to help us to study the weaknesses and strengths of our algorithm, thereby to further improvements of REDEN.

  18. Revised and enlarged edition: editorial production as an artistic and a literary genre

    Directory of Open Access Journals (Sweden)

    Sofia Gonçalves

    2016-07-01

    Full Text Available The appropriation of the expression «revised and enlarged edition», from the traditional publishing jargon, is presented in this article as a hypotheses to characterize contemporary publishing practices. It consid- ers the publication, in all its stages, as a writing space and as a process that never resigns creativity and criticism.These practices are «revised» (revisited because they imply the problematization of practice, through an exploratory attitude or critic, leading to processes and discourses prepared for a permanent review. And «en- larged» because they expand the operations of each editorial production phase, they iden- tify alternative formats and models, they blur traditional roles (author/editor/designer/ reader and question editing as a mere me- diation for the creation, circulation, reception or reading processes. In this article, we will identify some of the principles and emerging phenomena that help us understand editorial production as an artistic or a literary genre.

  19. New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins

    Directory of Open Access Journals (Sweden)

    Niamh Mannion

    2015-09-01

    Full Text Available The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA. Inosine can have a profound effect on the RNAs that are edited, not only changing the base-pairing properties, but can also result in recoding, as inosine behaves as if it were guanosine. In mammals there are three ADAR proteins and two ADAR-related proteins (ADAD expressed. All have a very similar modular structure; however, both their expression and biological function differ significantly. Only two of the ADAR proteins have enzymatic activity. However, both ADAR and ADAD proteins possess the ability to bind double-strand RNA. Mutations in ADARs have been associated with many diseases ranging from cancer, innate immunity to neurological disorders. Here, we will discuss in detail the domain structure of mammalian ADARs, the effects of RNA editing, and the role of ADARs in human diseases.

  20. Cellular function reinstitution of offspring red blood cells cloned from the sickle cell disease patient blood post CRISPR genome editing

    Directory of Open Access Journals (Sweden)

    Jianguo Wen

    2017-06-01

    Full Text Available Abstract Background Sickle cell disease (SCD is a disorder of red blood cells (RBCs expressing abnormal hemoglobin-S (HbS due to genetic inheritance of homologous HbS gene. However, people with the sickle cell trait (SCT carry a single allele of HbS and do not usually suffer from SCD symptoms, thus providing a rationale to treat SCD. Methods To validate gene therapy potential, hematopoietic stem cells were isolated from the SCD patient blood and treated with CRISPR/Cas9 approach. To precisely dissect genome-editing effects, erythroid progenitor cells were cloned from single colonies of CRISPR-treated cells and then expanded for simultaneous gene, protein, and cellular function studies. Results Genotyping and sequencing analysis revealed that the genome-edited erythroid progenitor colonies were converted to SCT genotype from SCD genotype. HPLC protein assays confirmed reinstallation of normal hemoglobin at a similar level with HbS in the cloned genome-edited erythroid progenitor cells. For cell function evaluation, in vitro RBC differentiation of the cloned erythroid progenitor cells was induced. As expected, cell sickling assays indicated function reinstitution of the genome-edited offspring SCD RBCs, which became more resistant to sickling under hypoxia condition. Conclusions This study is an exploration of genome editing of SCD HSPCs.

  1. Large-scale extraction of gene interactions from full-text literature using DeepDive.

    Science.gov (United States)

    Mallory, Emily K; Zhang, Ce; Ré, Christopher; Altman, Russ B

    2016-01-01

    A complete repository of gene-gene interactions is key for understanding cellular processes, human disease and drug response. These gene-gene interactions include both protein-protein interactions and transcription factor interactions. The majority of known interactions are found in the biomedical literature. Interaction databases, such as BioGRID and ChEA, annotate these gene-gene interactions; however, curation becomes difficult as the literature grows exponentially. DeepDive is a trained system for extracting information from a variety of sources, including text. In this work, we used DeepDive to extract both protein-protein and transcription factor interactions from over 100,000 full-text PLOS articles. We built an extractor for gene-gene interactions that identified candidate gene-gene relations within an input sentence. For each candidate relation, DeepDive computed a probability that the relation was a correct interaction. We evaluated this system against the Database of Interacting Proteins and against randomly curated extractions. Our system achieved 76% precision and 49% recall in extracting direct and indirect interactions involving gene symbols co-occurring in a sentence. For randomly curated extractions, the system achieved between 62% and 83% precision based on direct or indirect interactions, as well as sentence-level and document-level precision. Overall, our system extracted 3356 unique gene pairs using 724 features from over 100,000 full-text articles. Application source code is publicly available at https://github.com/edoughty/deepdive_genegene_app russ.altman@stanford.edu Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press.

  2. Ultrasonography in obstetrics and gynecology, 2nd edition

    International Nuclear Information System (INIS)

    Callen, P.W.

    1988-01-01

    A text on obstetric and gynecologic ultrasound for radiologists, OB/GYN practitioners, and radiologic technicians. The second edition places greater emphasis on diagnosis of specific systemic disorders in the fetus, as well as the most current applications of ultrasound in gynecologic diagnosis

  3. Identifying Scientific Project-generated Data Citation from Full-text Articles: An Investigation of TCGA Data Citation

    Directory of Open Access Journals (Sweden)

    Jiao Li

    2016-06-01

    Full Text Available Purpose: In the open science era, it is typical to share project-generated scientific data by depositing it in an open and accessible database. Moreover, scientific publications are preserved in a digital library archive. It is challenging to identify the data usage that is mentioned in literature and associate it with its source. Here, we investigated the data usage of a government-funded cancer genomics project, The Cancer Genome Atlas (TCGA, via a full-text literature analysis. Design/methodology/approach: We focused on identifying articles using the TCGA dataset and constructing linkages between the articles and the specific TCGA dataset. First, we collected 5,372 TCGA-related articles from PubMed Central (PMC. Second, we constructed a benchmark set with 25 full-text articles that truly used the TCGA data in their studies, and we summarized the key features of the benchmark set. Third, the key features were applied to the remaining PMC full-text articles that were collected from PMC. Findings: The amount of publications that use TCGA data has increased significantly since 2011, although the TCGA project was launched in 2005. Additionally, we found that the critical areas of focus in the studies that use the TCGA data were glioblastoma multiforme, lung cancer, and breast cancer; meanwhile, data from the RNA-sequencing (RNA-seq platform is the most preferable for use. Research limitations: The current workflow to identify articles that truly used TCGA data is labor-intensive. An automatic method is expected to improve the performance. Practical implications: This study will help cancer genomics researchers determine the latest advancements in cancer molecular therapy, and it will promote data sharing and data-intensive scientific discovery. Originality/value: Few studies have been conducted to investigate data usage by government-funded projects/programs since their launch. In this preliminary study, we extracted articles that use TCGA data

  4. Connectivity editing for quad-dominant meshes

    KAUST Repository

    Peng, Chihan

    2013-08-01

    We propose a connectivity editing framework for quad-dominant meshes. In our framework, the user can edit the mesh connectivity to control the location, type, and number of irregular vertices (with more or fewer than four neighbors) and irregular faces (non-quads). We provide a theoretical analysis of the problem, discuss what edits are possible and impossible, and describe how to implement an editing framework that realizes all possible editing operations. In the results, we show example edits and illustrate the advantages and disadvantages of different strategies for quad-dominant mesh design. © 2013 The Author(s) Computer Graphics Forum © 2013 The Eurographics Association and John Wiley & Sons Ltd.

  5. Text processing for technical reports (direct computer-assisted origination, editing, and output of text)

    Energy Technology Data Exchange (ETDEWEB)

    De Volpi, A.; Fenrick, M. R.; Stanford, G. S.; Fink, C. L.; Rhodes, E. A.

    1980-10-01

    Documentation often is a primary residual of research and development. Because of this important role and because of the large amount of time consumed in generating technical reports, particularly those containing formulas and graphics, an existing data-processing computer system has been adapted so as to provide text-processing of technical documents. Emphasis has been on accuracy, turnaround time, and time savings for staff and secretaries, for the types of reports normally produced in the reactor development program. The computer-assisted text-processing system, called TXT, has been implemented to benefit primarily the originator of technical reports. The system is of particular value to professional staff, such as scientists and engineers, who have responsibility for generating much correspondence or lengthy, complex reports or manuscripts - especially if prompt turnaround and high accuracy are required. It can produce text that contains special Greek or mathematical symbols. Written in FORTRAN and MACRO, the program TXT operates on a PDP-11 minicomputer under the RSX-11M multitask multiuser monitor. Peripheral hardware includes videoterminals, electrostatic printers, and magnetic disks. Either data- or word-processing tasks may be performed at the terminals. The repertoire of operations has been restricted so as to minimize user training and memory burden. Spectarial staff may be readily trained to make corrections from annotated copy. Some examples of camera-ready copy are provided.

  6. Is plant mitochondrial RNA editing a source of phylogenetic incongruence? An answer from in silico and in vivo data sets

    Directory of Open Access Journals (Sweden)

    Quagliariello Carla

    2008-03-01

    Full Text Available Abstract Background In plant mitochondria, the post-transcriptional RNA editing process converts C to U at a number of specific sites of the mRNA sequence and usually restores phylogenetically conserved codons and the encoded amino acid residues. Sites undergoing RNA editing evolve at a higher rate than sites not modified by the process. As a result, editing sites strongly affect the evolution of plant mitochondrial genomes, representing an important source of sequence variability and potentially informative characters. To date no clear and convincing evidence has established whether or not editing sites really affect the topology of reconstructed phylogenetic trees. For this reason, we investigated here the effect of RNA editing on the tree building process of twenty different plant mitochondrial gene sequences and by means of computer simulations. Results Based on our simulation study we suggest that the editing ‘noise’ in tree topology inference is mainly manifested at the cDNA level. In particular, editing sites tend to confuse tree topologies when artificial genomic and cDNA sequences are generated shorter than 500 bp and with an editing percentage higher than 5.0%. Similar results have been also obtained with genuine plant mitochondrial genes. In this latter instance, indeed, the topology incongruence increases when the editing percentage goes up from about 3.0 to 14.0%. However, when the average gene length is higher than 1,000 bp (rps3, matR and atp1 no differences in the comparison between inferred genomic and cDNA topologies could be detected. Conclusions Our findings by the here reported in silico and in vivo computer simulation system seem to strongly suggest that editing sites contribute in the generation of misleading phylogenetic trees if the analyzed mitochondrial gene sequence is highly edited (higher than 3.0% and reduced in length (shorter than 500 bp. In the current lack of direct experimental evidence the results

  7. Annotation of toponyms in TEI digital literary editions and linking to the web of data

    Directory of Open Access Journals (Sweden)

    Frontini, Francesca

    2016-07-01

    Full Text Available This paper aims to discuss the challenges and benefits of the annotation of place names in literary texts and literary criticism. We shall first highlight the problems of encoding spatial information in digital editions using the TEI format by means of two manual annotation experiments and the discussion of various cases. This will lead to the question of how to use existing semantic web resources to complement and enrich toponym mark-up, in particular to provide mentions with precise georeferencing. Finally the automatic annotation of a large corpus will show the potential of visualizing places from texts, by illustrating an analysis of the evolution of literary life from the spatial and geographical point of view.

  8. The Searchbench - Combining Sentence-semantic, Full-text and Bibliographic Search in Digital Libraries

    Directory of Open Access Journals (Sweden)

    Ulrich Schäfer

    2013-02-01

    Full Text Available We describe a novel approach to precise searching in the full content of digital libraries. The Searchbench (for search workbench is based on sentence-wise syntactic and semantic natural language processing (NLP of both born-digital and scanned publications in PDF format. The term born-digital means natively digital, i.e. prepared electronically using typesetting systems such as LaTeX, OpenOffice, and the like. In the Searchbench, queries can be formulated as (possibly underspecified statements, consisting of simple subject-predicate-object constructs such as ‘algorithm improves word alignment’. This reduces the number of false hits in large document collections when the search words happen to appear close to each other, but are not semantically related. The method also abstracts from passive voice and predicate synonyms. Moreover, negated statements can be excluded from the search results, and negated antonym predicates again count as synonyms (e.g. not include = exclude.In the Searchbench, a sentence-semantic search can be combined with search filters for classical full-text, bibliographic metadata and automatically computed domain terms. Auto-suggest fields facilitate text input. Queries can be bookmarked or emailed. Furthermore, a novel citation browser in the Searchbench allows graphical navigation in citation networks. These have been extracted automatically from metadata and paper texts. The citation browser displays short phrases from citation sentences at the edges in the citation graph and thus allows students and researchers to quickly browse publications and immerse into a new research field. By clicking on a citation edge, the original citation sentence is shown in context, and optionally also in the original PDF layout.To showcase the usefulness of our research, we have a applied it to a collection of currently approx. 25,000 open access research papers in the field of computational linguistics and language technology, the ACL

  9. [Preface for genome editing special issue].

    Science.gov (United States)

    Gu, Feng; Gao, Caixia

    2017-10-25

    Genome editing technology, as an innovative biotechnology, has been widely used for editing the genome from model organisms, animals, plants and microbes. CRISPR/Cas9-based genome editing technology shows its great value and potential in the dissection of functional genomics, improved breeding and genetic disease treatment. In the present special issue, the principle and application of genome editing techniques has been summarized. The advantages and disadvantages of the current genome editing technology and future prospects would also be highlighted.

  10. Handbook of radioactivity analysis. Second edition

    International Nuclear Information System (INIS)

    L'Annunziata, M.

    2003-07-01

    This updated and much expanded Second Edition is an authoritative handbook providing the principles, practical techniques, and procedures for the accurate measurement of radioactivity from the very low levels encountered in the environment to higher levels measured in radioisotope research, clinical laboratories, biological sciences, radionuclide standardization, nuclear medicine, nuclear power, fuel cycle facilities, and in the implementation of nuclear safeguards. The book describes the preparation of samples from a wide variety of matrices, assists the investigator or technician in the selection and use of appropriate radiation detectors, and presents state-of-the-art methods of analysis. Fundamentals of radioactivity properties, radionuclide decay, the calculations involved, and methods of detection provide the basis for a thorough understanding of the analytical procedures. The Handbook of Radioactivity Analysis, Second Edition is suitable as a teaching text for university and professional training courses

  11. Collaboration, editing, transparency: challenges and possibilities of a “wikification” of journalism

    Directory of Open Access Journals (Sweden)

    Carlos d'Andréa

    2009-06-01

    Full Text Available This article discusses the possibilities and challenges of the incorporation of wikis in journalistic editorial offices, especially in the processes involving the drafting and editing of texts. The reflection takes into consideration a context marked by 1 continuous fragmented publication of information; 2 simplification and horizontal organization of journalistic routines, which directly impacts the figure of the editor (mainly in the media on the web; and 3 increasing public participation in the development of the news, with the mediation of professionals. “Wiki-journalism” practices on the Wikinews and Wikipedia sites and initiatives originating with print publications are presented and discussed, and based on them we distinguish two models, which differ in the degree of control of the process by the journalists.

  12. Standards of specialized diabetes care. Edited by Dedov II, Shestakova MV (6th edition

    Directory of Open Access Journals (Sweden)

    Ivan Ivanovich Dedov

    2013-06-01

    Full Text Available Dear Colleagues!We are glad to present the 6th Edition of Standards of Diabetes Care. These evidence-based guidelines were designed to standardize and facilitate diabetes care in all regions of the Russian Federation. The Standards are updated on the regular basis to incorporate new data and relevant recommendations from national and international clinical societies, including World Health Organization Guidelines (WHO, 2011, International Diabetes Federation (IDF, 2011, American Diabetes Association (ADA, 2013, American Association of Clinical Endocrinologists (AACE, 2009, International Society for Pediatric and Adolescent Diabetes (ISPAD, 2009 and Russian Association of Endocrinologists (RAE, 2011, 2012. Current edition of the “Standards” also integrates results of completed randomized clinical trials (ADVANCE, ACCORD, VADT, UKPDS, etc., as well as findings from the national studies of diabetes mellitus (DM, conducted in close partnership with a number of Russian hospitals.Latest data indicates that prevalence of DM increased during the last decade more than two-fold, reaching some 371 million patients by 2013. According to the current estimation by the International Diabetes Federation, every tenth inhabitant of the planet will be suffering from DM by 2030. These observations resulted in the UN Resolution 61/225 passed on 20.12.2006 that encouraged all Member States “to develop national policies for the prevention, treatment and care of diabetes”.Like many other countries, Russian Federation experiences a sharp rise in the prevalence of DM. According to Russian State Diabetes Register, there are at least 3.799 million patients with DM in this country. However, the epidemiological survey conducted by the Federal Endocrinology Research Centre during 2002-2010 suggests that actual prevalence is 3 to 4 times greater than the officially recognized and, by this estimate, amounts to 9-10 million persons, comprising 7% of the

  13. Standards of specialized diabetes care. Edited by Dedov II, Shestakova MV (6th edition

    Directory of Open Access Journals (Sweden)

    Ivan Ivanovich Dedov

    2013-06-01

    Full Text Available Dear Colleagues!. We are glad to present the 6th Edition of Standards of Diabetes Care. These evidence-based guidelines were designed to standardize and facilitate diabetes care in all regions of the Russian Federation. The Standards are updated on the regular basis to incorporate new data and relevant recommendations from national and international clinical societies, including World Health Organization Guidelines (WHO, 2011, International Diabetes Federation (IDF, 2011, American Diabetes Association (ADA, 2013, American Association of Clinical Endocrinologists (AACE, 2009, International Society for Pediatric and Adolescent Diabetes (ISPAD, 2009 and Russian Association of Endocrinologists (RAE, 2011, 2012. Current edition of the ?Standards? also integrates results of completed randomized clinical trials (ADVANCE, ACCORD, VADT, UKPDS, etc., as well as findings from the national studies of diabetes mellitus (DM, conducted in close partnership with a number of Russian hospitals. Latest data indicates that prevalence of DM increased during the last decade more than two-fold, reaching some 371 million patients by 2013. According to the current estimation by the International Diabetes Federation, every tenth inhabitant of the planet will be suffering from DM by 2030. These observations resulted in the UN Resolution 61/225 passed on 20.12.2006 that encouraged all Member States ?to develop national policies for the prevention, treatment and care of diabetes?. Like many other countries, Russian Federation experiences a sharp rise in the prevalence of DM. According to Russian State Diabetes Register, there are at least 3.799 million patients with DM in this country. However, the epidemiological survey conducted by the Federal Endocrinology Research Centre during 2002-2010 suggests that actual prevalence is 3 to 4 times greater than the officially recognized and, by this estimate, amounts to 9-10 million persons, comprising 7% of the national

  14. Standards of specialized diabetes care. Edited by Dedov I.I., Shestakova M.V. (7th edition

    Directory of Open Access Journals (Sweden)

    Ivan Ivanovich Dedov

    2015-03-01

    Full Text Available We are glad to present the 7th Edition of Standards of Diabetes Care. These evidence-based guidelines were designed to standardize and facilitate diabetes care in all regions of the Russian Federation. The Standards are updated on the regular basis to incorporate new data and relevant recommendations from national and international clinical societies, including World Health Organization Guidelines (WHO, 2011, 2013, International Diabetes Federation (IDF, 2011, 2012, 2013, American Diabetes Association (ADA, 2012, 2015, American Association of Clinical Endocrinologists (AACE, 2013, International Society for Pediatric and Adolescent Diabetes (ISPAD, 2014 and Russian Association of Endocrinologists (RAE, 2011, 2012. Current edition of the “Standards” also integrates results of completed randomized clinical trials (ADVANCE, ACCORD, VADT, UKPDS, etc., as well as findings from the national studies of diabetes mellitus (DM, conducted in close partnership with a number of Russian hospitals.Latest data indicates that prevalence of DM increased during the last decade more than two-fold, reaching some 387 million patients by the end of 2014. According to the current estimation by the International Diabetes Federation, 592 million patients will be suffering from DM by 2035. These observations resulted in the UN Resolution 61/225 passed on 20.12.2006 that encouraged all Member States “to develop national policies for the prevention, treatment and care of diabetes”.Like many other countries, Russian Federation experiences a sharp rise in the prevalence of DM. According to Russian State Diabetes Register, there are at least 4.1 million patients with DM in this country. However, the epidemiological survey conducted by the Federal Endocrinology Research Centre during 2002-2010 suggests that actual prevalence is 3 to 4 times greater than the officially recognized and, by this estimate, amounts to 9-10 million persons, comprising 7% of the national

  15. Standards of specialized diabetes care. Edited by Dedov I.I., Shestakova M.V. (7th edition

    Directory of Open Access Journals (Sweden)

    Ivan Ivanovich Dedov

    2015-03-01

    Full Text Available We are glad to present the 7th Edition of Standards of Diabetes Care. These evidence-based guidelines were designed to standardize and facilitate diabetes care in all regions of the Russian Federation. The Standards are updated on the regular basis to incorporate new data and relevant recommendations from national and international clinical societies, including World Health Organization Guidelines (WHO, 2011, 2013, International Diabetes Federation (IDF, 2011, 2012, 2013, American Diabetes Association (ADA, 2012, 2015, American Association of Clinical Endocrinologists (AACE, 2013, International Society for Pediatric and Adolescent Diabetes (ISPAD, 2014 and Russian Association of Endocrinologists (RAE, 2011, 2012. Current edition of the ?Standards? also integrates results of completed randomized clinical trials (ADVANCE, ACCORD, VADT, UKPDS, etc., as well as findings from the national studies of diabetes mellitus (DM, conducted in close partnership with a number of Russian hospitals. Latest data indicates that prevalence of DM increased during the last decade more than two-fold, reaching some 387 million patients by the end of 2014. According to the current estimation by the International Diabetes Federation, 592 million patients will be suffering from DM by 2035. These observations resulted in the UN Resolution 61/225 passed on 20.12.2006 that encouraged all Member States "to develop national policies for the prevention, treatment and care of diabetes". Like many other countries, Russian Federation experiences a sharp rise in the prevalence of DM. According to Russian State Diabetes Register, there are at least 4.1 million patients with DM in this country. However, the epidemiological survey conducted by the Federal Endocrinology Research Centre during 2002-2010 suggests that actual prevalence is 3 to 4 times greater than the officially recognized and, by this estimate, amounts to 9-10 million persons, comprising 7% of the national population

  16. BC4GO: a full-text corpus for the BioCreative IV GO task.

    Science.gov (United States)

    Van Auken, Kimberly; Schaeffer, Mary L; McQuilton, Peter; Laulederkind, Stanley J F; Li, Donghui; Wang, Shur-Jen; Hayman, G Thomas; Tweedie, Susan; Arighi, Cecilia N; Done, James; Müller, Hans-Michael; Sternberg, Paul W; Mao, Yuqing; Wei, Chih-Hsuan; Lu, Zhiyong

    2014-01-01

    Gene function curation via Gene Ontology (GO) annotation is a common task among Model Organism Database groups. Owing to its manual nature, this task is considered one of the bottlenecks in literature curation. There have been many previous attempts at automatic identification of GO terms and supporting information from full text. However, few systems have delivered an accuracy that is comparable with humans. One recognized challenge in developing such systems is the lack of marked sentence-level evidence text that provides the basis for making GO annotations. We aim to create a corpus that includes the GO evidence text along with the three core elements of GO annotations: (i) a gene or gene product, (ii) a GO term and (iii) a GO evidence code. To ensure our results are consistent with real-life GO data, we recruited eight professional GO curators and asked them to follow their routine GO annotation protocols. Our annotators marked up more than 5000 text passages in 200 articles for 1356 distinct GO terms. For evidence sentence selection, the inter-annotator agreement (IAA) results are 9.3% (strict) and 42.7% (relaxed) in F1-measures. For GO term selection, the IAAs are 47% (strict) and 62.9% (hierarchical). Our corpus analysis further shows that abstracts contain ∼ 10% of relevant evidence sentences and 30% distinct GO terms, while the Results/Experiment section has nearly 60% relevant sentences and >70% GO terms. Further, of those evidence sentences found in abstracts, less than one-third contain enough experimental detail to fulfill the three core criteria of a GO annotation. This result demonstrates the need of using full-text articles for text mining GO annotations. Through its use at the BioCreative IV GO (BC4GO) task, we expect our corpus to become a valuable resource for the BioNLP research community. Database URL: http://www.biocreative.org/resources/corpora/bc-iv-go-task-corpus/. Published by Oxford University Press 2014. This work is written by US

  17. Efficient CRISPR/Cas9 Genome Editing of Phytoene desaturase in Cassava

    Directory of Open Access Journals (Sweden)

    John Odipio

    2017-10-01

    Full Text Available CRISPR/Cas9 has become a powerful genome-editing tool for introducing genetic changes into crop species. In order to develop capacity for CRISPR/Cas9 technology in the tropical staple cassava (Manihot esculenta, the Phytoene desaturase (MePDS gene was targeted in two cultivars using constructs carrying gRNAs targeting two sequences within MePDS exon 13. After Agrobacterium-mediated delivery of CRISPR/Cas9 reagents into cassava cells, both constructs induced visible albino phenotypes within cotyledon-stage somatic embryos regenerating on selection medium and the plants regenerated therefrom. A total of 58 (cv. 60444 and 25 (cv. TME 204 plant lines were recovered, of which 38 plant lines (19 from each cultivar were analyzed for mutagenesis. The frequency of plant lines showing albino phenotype was high, ranging from 90 to 100% in cv. TME 204. Observed albino phenotypes were comprised of full albinos devoid of green tissue and chimeras containing a mixture of white and green tissues. Sequence analysis revealed that 38/38 (100% of the plant lines examined carried mutations at the targeted MePDS site, with insertions, deletions, and substitutions recorded. One putatively mono-allelic homozygous line (1/19 was found from cv. 60444, while 1 (1/19 and 4 (4/19 putatively bi-allelic homozygous lines were found in 60444 and TME204, respectively. The remaining plant lines, comprised mostly of the chimeras, were found to be putatively heterozygous. We observed minor (1 bp nucleotide substitutions and or deletions upstream of the 5′ and or downstream of the 3′ targeted MePDS region. The data reported demonstrates that CRISPR/Cas9-mediated genome editing of cassava is highly efficient and relatively simple, generating multi-allelic mutations in both cultivars studied. Modification of MePDS described here generates visually detectable mutated events in a relatively short time frame of 6–8 weeks, and does not require sequencing to confirm editing at the

  18. Toward a Critique of Surveillance in the Age of the Internet: A Reflection on the “Internet and Surveillance” Volume Edited by Fuchs, Boersma, Albrechtslund, and Sandoval

    Directory of Open Access Journals (Sweden)

    Jernej Prodnik

    2012-02-01

    Full Text Available This article is a reflection on the following book (edited volume: Fuchs, Christian, Kees Boersma, Anders Albrechtslund, and Marisol Sandoval, eds. 2012. Internet and Surveillance: The Challenges of Web 2.0 and Social Media. New York: Routledge.

  19. Watson's behaviorism: a comparison of the two editions (1925 and 1930).

    Science.gov (United States)

    Carpintero, Helio

    2004-05-01

    J.B. Watson's Behaviorism, a complete presentation of the mature psychological points of view of its author, had 2 editions, in 1925 and 1930, which presented significant differences in their texts. Although Watson maximized such variations, to the point of considering the 2nd edition as nearly a brand-new book, both suppressions and additions reveal his feelings when presenting his ideas to a general audience. Such variations are here presented through an in-depth analysis.

  20. Scholarly Electronic Full-Text Publications via the Internet: Issues and Impacts

    Science.gov (United States)

    Kosmin, Linda J.

    1999-01-01

    On-line access to complete texts of scholarly journal articles, conference papers, and books is facilitated by rapidly developing World-wide Web Internet access and capabilities. Meanwhile, print publications continue to be produced and read in spite of the proliferation of many networked electronic publications. The purpose of this presentation is to highlight fundamental issues impacting stakeholder groups, as the trend continues towards migration from paper to affordable ubiquitous networked full-text publications. Librarians, publishers, authors and end-users have various viewpoints, interests, and concerns. There are many issues challenging all stakeholder groups. For instance, all share concerns about administering copyright compliance and enforcing fair use. Uncontrollable electronic downstreaming could result in infringed copyright, while limiting a publisher's entitled revenue stream. Moreover, metered fee-based access may hamper scholarly information research. And, self-authoring on the Internet without peer filtering could lead to information clutter. Many related issues challenge librarians in particular. Among these are rising journal subscription prices, regardless if offered in print or electronic. Some electronic offerings are independent of print, others supplement or duplicate print; several publishers presently require subscribing to print in order to access electronic. Furthermore, numbers of publications are n'ow being marketed via the Internet directly to end-users, which can be viewed as encouraging users to bypass the traditional library. A key issue challenging publishers today is the rapidly expanding electronic user base that is demanding delivery of added-value full-text to desktop computers. Also of growing concern appears to be the decline in print sales to libraries, thereby reducing traditional revenue stream potential. Nowadays, publishers are more hesitant about investing in the production of publications geared toward small niche

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    Dale E. Zand (1997) argues that People once stood in awe of electricity, until ... in today's information-driven organizations: knowledge, trust, and power. ..... people's culture and resistance to anti-corruption efforts constitute the firmly fixed load.

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    The overshadowing of education policies in foreign language education at primary .... Cummins states that a threshold level of linguistics competence must be ..... language education planning is designed to accommodate these interests.

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    Hence, the main objective of the research was to carry out scientific studies on its ... The animals were sacrificed on day 30 after the NIB scoring and blood sample ... effect on locomotion and rearing activities when compared with the control.

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    Epidemiological study has shown that 2.5 million deaths occurred every year as a result of vaccine-preventable diseases, mainly in Africa and Asia among children less than 5 years old (GIVS, 2005). Immunization is the process of conferring increased resistance to an infectious disease by a means other than experiencing ...

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    Keywords: Technology, French as a foreign language, Learners, Instruction ... This translates to an increase of 3.7 percent or 1.4 million new mobile subscriptions ... technology (ICT) in foreign language learning and the availability as well as capacities ..... In spite of the many benefits of creating an authentic French learning ...

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    Pablo Rubio Gijon

    Hishongwa belongs to a generation of writers who created a new style of expression in .... authority, can turn this authority into something even more autocratic. ... leadership of that (liberation) struggle” (Haarhoff 224), Hishongwa's Marrying ...

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    In English, this class includes the particles how, too, so, and as (Ibid). (3) Mary is ...... Doctoral thesis (unpublished), University of Dar es Salaam. Goodness, D. .... manga. fat. corpulent. 36. mbindipindi. green. 37. mwalo. naughty. absurd. 38.

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    ... country and mass migration of the farming communities to IDP camps in major cities ..... "Global Warming Impact: Flood Events, Wet-Dry Conditions and Changing ... Global Environmental Change, Vol. 16, pp. 268-281.Web. Adger, W. N. (1999). "Social Vulnerability to Climate Change and Extremes in Coastal Vietnam.

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    By paying strict attention to the manipulation of action and dialogue, the short story ... through the workings of the human mind as he reacts to various predicaments. .... In “A Caring Man,” in A Forest of Flowers, Ken Saro-Wiwa illustrates the theme of .... until his small dirty pillow is thrown out of the window of the moving train.

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    Oita Etyang

    The concept democracy has been part of man's political life for ages. ... Taking the queue form Bratton and Mattes, we add that prospects of a stable democracy are ..... of the resulting instability that emanate from entrenched ethnic cleavages.

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    Adopting a surveillance system for antibacterial use has therefore become a more realistic ..... Financial support was obtained from the African Poverty Related Infection ... classification and Defined Daily Dose system methodology in Canada.

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    TAOFEEK YUSUF

    The data used were obtained through questionnaires administered to ... Keywords: academic performance, engineering education, undergraduate students, and .... and commitment to studies irrespective of any form of learning task Yusuf et al.

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    Njeri

    He took his children to St Marys, I could not afford to do so. ... place in universities should have been an important learning space for students. ... just us we are fascinated by Manchester football clubs and western movies as well as music.

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    Language and Meaning: A Syntactic Study of Wale Okediran's Strange Encounters ... own communication role, making assertions, asking questions, giving orders, ... I will go straight to the police with all the things you stole from the hospital.

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    paula fiona mwikali

    The Portrayal of Masculinity in Dholuo Ohangla Music ... The Luo culture is built on patriarchy and the socialization of the children ..... A leader must be strong because those he/ she leads look up to him/her for direction, assistance and development. ... Being a loyal lieutenant of Orange Democratic Movement, Anyanga ...

  16. Oligophrenin-1 (OPHN1, a gene involved in X-linked intellectual disability, undergoes RNA editing and alternative splicing during human brain development.

    Directory of Open Access Journals (Sweden)

    Sabina Barresi

    Full Text Available Oligophrenin-1 (OPHN1 encodes for a Rho-GTPase-activating protein, important for dendritic morphogenesis and synaptic function. Mutations in this gene have been identified in patients with X-linked intellectual disability associated with cerebellar hypoplasia. ADAR enzymes are responsible for A-to-I RNA editing, an essential post-transcriptional RNA modification contributing to transcriptome and proteome diversification. Specifically, ADAR2 activity is essential for brain development and function. Herein, we show that the OPHN1 transcript undergoes post-transcriptional modifications such as A-to-I RNA editing and alternative splicing in human brain and other tissues. We found that OPHN1 editing is detectable already at the 18th week of gestation in human brain with a boost of editing at weeks 20 to 33, concomitantly with OPHN1 expression increase and the appearance of a novel OPHN1 splicing isoform. Our results demonstrate that multiple post-transcriptional events occur on OPHN1, a gene playing an important role in brain function and development.

  17. High-efficiency targeted editing of large viral genomes by RNA-guided nucleases.

    Directory of Open Access Journals (Sweden)

    Yanwei Bi

    2014-05-01

    Full Text Available A facile and efficient method for the precise editing of large viral genomes is required for the selection of attenuated vaccine strains and the construction of gene therapy vectors. The type II prokaryotic CRISPR-Cas (clustered regularly interspaced short palindromic repeats (CRISPR-associated (Cas RNA-guided nuclease system can be introduced into host cells during viral replication. The CRISPR-Cas9 system robustly stimulates targeted double-stranded breaks in the genomes of DNA viruses, where the non-homologous end joining (NHEJ and homology-directed repair (HDR pathways can be exploited to introduce site-specific indels or insert heterologous genes with high frequency. Furthermore, CRISPR-Cas9 can specifically inhibit the replication of the original virus, thereby significantly increasing the abundance of the recombinant virus among progeny virus. As a result, purified recombinant virus can be obtained with only a single round of selection. In this study, we used recombinant adenovirus and type I herpes simplex virus as examples to demonstrate that the CRISPR-Cas9 system is a valuable tool for editing the genomes of large DNA viruses.

  18. A test of unification towards the radio source PKS1413+135

    International Nuclear Information System (INIS)

    Ferreira, M.C.; Julião, M.D.; Martins, C.J.A.P.; Monteiro, A.M.R.V.L.

    2013-01-01

    We point out that existing astrophysical measurements of combinations of the fine-structure constant α, the proton-to-electron mass ratio μ and the proton gyromagnetic ratio g p towards the radio source PKS1413+135 can be used to individually constrain each of these fundamental couplings. While the accuracy of the available measurements is not yet sufficient to test the spatial dipole scenario, our analysis serves as a proof of concept as new observational facilities will soon allow significantly more robust tests. Moreover, these measurements can also be used to obtain constraints on certain classes of unification scenarios, and we compare the constraints obtained for PKS1413+135 with those previously obtained from local atomic clock measurements

  19. A test of unification towards the radio source PKS1413+135

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, M.C., E-mail: up200802537@fc.up.pt [Centro de Astrofísica, Universidade do Porto, Rua das Estrelas, 4150-762 Porto (Portugal); Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, 4150-007 Porto (Portugal); Julião, M.D., E-mail: meinf12013@fe.up.pt [Centro de Astrofísica, Universidade do Porto, Rua das Estrelas, 4150-762 Porto (Portugal); Faculdade de Engenharia, Universidade do Porto, Rua Dr Roberto Frias, 4200-465 Porto (Portugal); Martins, C.J.A.P., E-mail: Carlos.Martins@astro.up.pt [Centro de Astrofísica, Universidade do Porto, Rua das Estrelas, 4150-762 Porto (Portugal); Monteiro, A.M.R.V.L., E-mail: mmonteiro@fc.up.pt [Centro de Astrofísica, Universidade do Porto, Rua das Estrelas, 4150-762 Porto (Portugal); Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, 4150-007 Porto (Portugal); Department of Applied Physics, Delft University of Technology, P.O. Box 5046, 2600 GA Delft (Netherlands)

    2013-07-09

    We point out that existing astrophysical measurements of combinations of the fine-structure constant α, the proton-to-electron mass ratio μ and the proton gyromagnetic ratio g{sub p} towards the radio source PKS1413+135 can be used to individually constrain each of these fundamental couplings. While the accuracy of the available measurements is not yet sufficient to test the spatial dipole scenario, our analysis serves as a proof of concept as new observational facilities will soon allow significantly more robust tests. Moreover, these measurements can also be used to obtain constraints on certain classes of unification scenarios, and we compare the constraints obtained for PKS1413+135 with those previously obtained from local atomic clock measurements.

  20. Cumulating the Supplements to the Seventh Edition of LC Subject Headings

    Directory of Open Access Journals (Sweden)

    Roy B. Torkington

    1973-12-01

    Full Text Available A description is presented of the project of the University of California Library Automation Program to cumulate the 1966 through 1971 supplements to the Library of Congress Subject Headings. The University of California Institute of Library Research MARC processing software, BIBCON, was used, with specially written programs. The resulting cumulation was edited, printed in book form, and made available to libraries. The final task involved merging six MARC files into one file of over 125,000 records and then printing that file in a format similar to that of LC Subject Headings. The project was a cooperative effort with participation by people from several UC campuses.