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Sample records for undifferentiated tertiary rocks

  1. Favorability for uranium in tertiary sedimentary rocks, southwestern Montana

    International Nuclear Information System (INIS)

    Wopat, M.A.; Curry, W.E.; Robins, J.W.; Marjaniemi, D.K.

    1977-10-01

    Tertiary sedimentary rocks in the basins of southwestern Montana were studied to determine their favorability for potential uranium resources. Uranium in the Tertiary sedimentary rocks was probably derived from the Boulder batholith and from silicic volcanic material. The batholith contains numerous uranium occurrences and is the most favorable plutonic source for uranium in the study area. Subjective favorability categories of good, moderate, and poor, based on the number and type of favorable criteria present, were used to classify the rock sequences studied. Rocks judged to have good favorability for uranium deposits are (1) Eocene and Oligocene strata and undifferentiated Tertiary rocks in the western Three Forks basin and (2) Oligocene rocks in the Helena basin. Rocks having moderate favorability consist of (1) Eocene and Oligocene strata in the Jefferson River, Beaverhead River, and lower Ruby River basins, (2) Oligocene rocks in the Townsend and Clarkston basins, (3) Miocene and Pliocene rocks in the Upper Ruby River basin, and (4) all Tertiary sedimentary formations in the eastern Three Forks basin, and in the Grasshopper Creek, Horse Prairie, Medicine Lodge Creek, Big Sheep Creek, Deer Lodge, Big Hole River, and Bull Creek basins. The following have poor favorability: (1) the Beaverhead Conglomerate in the Red Rock and Centennial basins, (2) Eocene and Oligocene rocks in the Upper Ruby River basin, (3) Miocene and Pliocene rocks in the Townsend, Clarkston, Smith River, and Divide Creek basins, (4) Miocene through Pleistocene rocks in the Jefferson River, Beaverhead River, and Lower Ruby River basins, and (5) all Tertiary sedimentary rocks in the Boulder River, Sage Creek, Muddy Creek, Madison River, Flint Creek, Gold Creek, and Bitterroot basins

  2. Acute undifferentiated febrile illness in patients presenting to a Tertiary Care Hospital in South India: clinical spectrum and outcome

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    Kundavaram Paul Prabhakar Abhilash

    2016-01-01

    Full Text Available Background: Acute undifferentiated febrile illness (AUFI may have similar clinical presentation, and the etiology is varied and region specific. Materials and Methods: This prospective observational study was conducted in a tertiary hospital in South India. All adult patients presenting with AUFI of 3-14 days duration were evaluated for etiology, and the differences in presentation and outcome were analyzed. Results: The study cohort included 1258 patients. A microbiological cause was identified in 82.5% of our patients. Scrub typhus was the most common cause of AUFI (35.9% followed by dengue (30.6%, malaria (10.4%, enteric fever (3.7%, and leptospirosis (0.6%. Both scrub typhus and dengue fever peaked during the monsoon season and the cooler months, whereas no seasonality was observed with enteric fever and malaria. The mean time to presentation was longer in enteric fever (9.9 [4.7] days and scrub typhus (8.2 [3.2] days. Bleeding manifestations were seen in 7.7% of patients, mostly associated with dengue (14%, scrub typhus (4.2%, and malaria (4.6%. The requirement of supplemental oxygen, invasive ventilation, and inotropes was higher in scrub typhus, leptospirosis, and malaria. The overall mortality rate was 3.3% and was highest with scrub typhus (4.6% followed by dengue fever (2.3%. Significant clinical predictors of scrub typhus were breathlessness (odds ratio [OR]: 4.96; 95% confidence interval [CI]: 3.38-7.3, total whole blood cell count >10,000 cells/mm 3 (OR: 2.31; 95% CI: 1.64-3.24, serum albumin <3.5 g % (OR: 2.32; 95% CI: 1.68-3.2. Overt bleeding manifestations (OR: 2.98; 95% CI: 1.84-4.84, and a platelet count of <150,000 cells/mm 3 (OR: 2.09; 95% CI: 1.47-2.98 were independent predictors of dengue fever. Conclusion: The similarity in clinical presentation and diversity of etiological agents demonstrates the complexity of diagnosis and treatment of AUFI in South India. The etiological profile will be of use in the development of

  3. Tertiary volcanic rocks of the Mineral Mountain and Teapot Mountain quadrangles, Pinal County, Arizona

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    Keith, William J.; Theodore, Ted G.

    1979-01-01

    The widespread distribution of Tertiary volcanic rocks in south-central Arizona is controlled in part by prevolcanic structures along which volcanic vents were localized. Volcanic rocks in the Mineral Mountain and Teapot Mountain quadrangles mark the site of a major northwest-trending structural hingeline. This hingeline divides an older Precambrian X terrane on the west from intensely deformed sequences of rock as young as Pennsylvanian on the east, suggesting increased westerly uplift. The volcanic rocks consist of a pile of complexly interlayered rhyolite, andesite, dacite, flows and intrusive rocks, water-laid tuffs, and very minor olivine basalt. Although the rocks erupted from several different vents, time relations, space relations, and chemistry each give strong evidence of a single source for all the rocks. Available data (by the K-Ar dating method) on hornblende and biotite separates from the volcanic rocks range from 14 to 19 m.y. and establish the pre-middle Miocene age of major dislocations along the structural hingeline. Most of the volcanic rocks contain glass, either at the base of the flows or as an envelope around the intrusive phases. One of the intrusive rhyolites, however, seems to represent one of the final eruptions. Intense vesiculation of the intrusive rhyolite suggests a large content of volatiles at the time of its eruption. Mineralization is associated with the more silicic of these middle Miocene volcanic rocks; specifically, extensive fissure quartz veins contain locally significant amounts of silver, lead, and zinc and minor amounts of gold. Many of the most productive deposits are hosted by the volcanic rocks, although others occur in the Precambrian rocks. Magnetic data correspond roughly to the geology in outlining the overall extent of the volcanic rocks as a magnetic low.

  4. K-Ar age of the Tertiary volcanic rocks in the Tohoku area, Japan

    International Nuclear Information System (INIS)

    Konda, Tadashi; Ueda, Yoshio.

    1980-01-01

    The absolute age of the Tertiary volcanic rocks in Tohoku area has been estimated by K-Ar method. The results are: (1) in case of the volcanic rocks of Monzen-Aikawa stage, 32.8 - 38.5 m.y.B.P., (2) in case of the volcanic rocks of Nozaki-Daijima stage, 22.0 - 25.1 m.y.B.P., (3) in case of the volcanic rocks of Nishikurosawa stage, 15.5 - 16.5 m.y.B.P., (4) in case of the volcanic rocks of Onnagawa stage, 12.6 - 14.8 m.y.B.P., (5) in case of the volcanic rocks of Funakawa stage, 9.6 - 11.3 m.y.B.P., and (6) in case of the volcanic rocks of Kitaura stage, 6.9 - 9.0 m.y.B.P. The samples used are such as biotite and whole rocks. The eruption periods in Tertiary volcanic activities presumed by K-Ar method are geologically significant. In the measurements made on the same system of samples under same conditions, there was difference in the K-Ar ages between the Monzen-Aikawa and the Nozaki-Daijima stages, and it was significantly noteworthy. It is indicated that the volcanic rock activities in the former stage had took place before those in the latter stage. In the Tohoku arc of northern Japan, the simultaneity in initial volcanic activities is not seen in the direction across the arc. (J.P.N.)

  5. Depositional setting and diagenetic evolution of some Tertiary unconventional reservoir rocks, Uinta Basin, Utah.

    Science.gov (United States)

    Pitman, Janet K.; Fouch, T.D.; Goldhaber, M.B.

    1982-01-01

    The Douglas Creek Member of the Tertiary Green River Formation underlies much of the Uinta basin, Utah, and contains large volumes of oil and gas trapped in a complex of fractured low-permeability sandstone reservoirs. In the SE part of the basin at Pariette Bench, the Eocene Douglas Creek Member is a thick sequence of fine- grained alluvial sandstone complexly intercalated with lacustrine claystone and carbonate rock. Sediments were deposited in a subsiding intermontane basin along the shallow fluctuating margin of ancient Lake Uinta. Although the Uinta basin has undergone postdepositional uplift and erosion, the deepest cored rocks at Pariette Bench have never been buried more than 3000m.-from Authors

  6. Precious metals associated with Late Cretaceous-early Tertiary igneous rocks of southwestern Alaska

    Science.gov (United States)

    Bundtzen, Thomas K.; Miller, Marti L.; Goldfarb, Richard J.; Miller, Lance D.

    1997-01-01

    Placer gold and precious metal-bearing lode deposits of southwestern Alaska lie within a region 550 by 350 km, herein referred to as the Kuskokwim mineral belt. This mineral belt has yielded 100,240 kg (3.22 Moz) of gold, 12, 813 kg (412,000 oz) of silver, 1,377,412 kg (39,960 flasks) of mercury, and modest amounts of antimony and tungsten derived primarily from the late Cretaceous-early Tertiary igneous complexes of four major types: (1) alkali-calcic, comagmatic volcanic-plutonic complexes and isolated plutons, (2) calc-alkaline, meta-aluminous reduced plutons, (3) peraluminous alaskite or granite-porphyry sills and dike swarms, and (4) andesite-rhyolite subaerial volcanic rocks.About 80 percent of the 77 to 52 Ma intrusive and volcanic rocks intrude or overlie the middle to Upper Cretaceous Kuskokwim Group sedimentary and volcanic rocks, as well as the Paleozoic-Mesozoic rocks of the Nixon Fork, Innoko, Goodnews, and Ruby preaccretionary terranes.The major precious metal-bearing deposit types related to Late Cretaceous-early Tertiary igneous complexes of the Kuskokwim mineral belt are subdivided as follows: (1) plutonic-hosted copper-gold polymetallic stockwork, skarn, and vein deposits, (2) peraluminous granite-porphory-hosted gold polymetallic deposits, (3) plutonic-related, boron-enriched silver-tin polymetallic breccia pipes and replacement deposits, (4) gold and silver mineralization in epithermal systems, and (5) gold polymetallic heavy mineral placer deposits. Ten deposits genetically related to Late Cretaceous-early Tertiary intrusions contain minimum, inferred reserves amounting to 162,572 kg (5.23 Moz) of gold, 201,015 kg (6.46 Moz) silver, 12,160 metric tons (t) of tin, and 28,088 t of copper.The lodes occur in veins, stockworks, breccia pipes, and replacement deposits that formed in epithermal to mesothermal temperature-pressure conditions. Fluid inclusion, isotopic age, mineral assemblage, alteration assemblage, and structural data indicate that

  7. Petrography, geochemistry and tectonic setting of Salmabad Tertiary volcanic rocks, southeast of Sarbisheh, eastern Iran

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    Masoumeh Goodarzi

    2014-10-01

    Full Text Available Introduction The area reviewed and studied in this paper is located 5 km southeast of Sarbisheh city at eastern border of the Lut block (Jung et al., 1983; Karimpour et al., 2011; Richards et al., 2012 in eastern Iran between 59° 47′ and 59° 53′ E longitude and 32°30′ and 32°34′ N latitude. The magmatic activity in the Lut block began in middle Jurassic (165-162 Ma and reached its peak in Tertiary (Jung et al., 1983. Volcanic and subvolcanic rocks of Tertiary age cover over half of Lut block with up to 2000 m thickness and formed due to subduction prior to the collision of the Arabian and Asian plates (Camp and Griffis, 1982; Tirrul et al., 1983; Berberianet et al., 1982. Most of magmatic activity in the Lut block formed in middle Eocene (Karimpour et al., 2011 The andesitic volcanics were erupted together with the dacites and rhyodacites during a time interval of some 50 Ma from early Cretaceous to early Neogene. It can be assumed that the intensity of the volcanic activity was varying significantly during this time span (Jung et al., 1983.Tertiary volcanic rocks (Eocene-Oligocene to Pliocene with intermediate composition associated with pyroclastic rocks cropped out in eastern parts of Salmabad village, southeast of Sarbisheh. The main purpose of this paper is better understand the tectono-magmatic setting of the Tertiary volcanic rocks in southeast of Sarbisheh, eastern Iran based on geochemical characteristics. Materials and methods Eleven samples were analyzed for major elements by inductively coupled plasma (ICP technologies and trace elements were analyzed using inductively coupled plasma mass spectrometry (ICP-MS, following a lithium metaborate/tetraborate fusion and nitric acid total digestion, at the SGS Laboratories, Toronto, Canada. Results In the Salmabad area, Tertiary volcanic rocks with mainly intermediate (andesitic composition are exposed associated with pyroclastic deposits such as tuff, breccia and agglomerate

  8. Undifferentiated salivary gland carcinomas

    DEFF Research Database (Denmark)

    Herbst, H.; Hamilton-Dutoit, S.; Jakel, K.T.

    2004-01-01

    Undifferentiated salivary gland carcinomas may be divided into small cell and large cell types. Among large cell undifferentiated carcinomas, lymphoepithelial carcinomas have to be distinguished, the latter of which are endemic in the Arctic regions and southern China where virtually all cases of...... at other primary sites, particularly when expressing the thyroid transcription factor-1 (TTF-1) Udgivelsesdato: 2004...

  9. Uranium favorability of tertiary sedimentary rocks of the Pend Oreille River valley, Washington

    International Nuclear Information System (INIS)

    Marjaniemi, D.K.; Robins, J.W.

    1975-08-01

    Tertiary sedimentary rocks in the Pend Oreille River valley were investigated in a regional study to determine the favorability for potential uranium resources of northeastern Washington. This project involved measurement and sampling of surface sections, collection of samples from isolated outcrops, chemical and mineralogical analyses of samples, and examination of available water well logs. The Box Canyon Dam area north of Ione is judged to have very high favorability. Thick-bedded conglomerates interbedded with sandstones and silty sandstones compose the Tiger Formation in this area, and high radioactivity levels are found near the base of the formation. Uranophane is found along fracture surfaces or in veins. Carbonaceous material is present throughout the Tiger Formation in the area. Part of the broad Pend Oreille valley surrounding Cusick, Washington, is an area of high favorability. Potential host rocks in the Tiger Formation, consisting of arkosic sandstones interbedded with radioactive shales, probably extend throughout the subsurface part of this area. Carbonaceous material is present and some samples contain high concentrations of uranium. In addition, several other possible chemical indicators were found. The Tiger-Lost Creek area is rated as having medium favorability. The Tiger Formation contains very hard, poorly sorted granite conglomerate with some beds of arkosic sandstone and silty sandstone. The granite conglomerate was apparently derived from source rocks having relatively high uranium content. The lower part of the formation is more favorable than the upper part because of the presence of carbonaceous material, anomalously high concentrations of uranium, and other possible chemical indicators. The area west of Ione is judged to have low favorability, because of the very low permeability of the rocks and the very low uranium content

  10. Tectonostratigraphic reconstruction and lithofacies distribution of tertiary slope sedimentary rocks in the Western Mississippi Canyon area

    Energy Technology Data Exchange (ETDEWEB)

    Hannan, A.E.; Risch, D.L.; Chowdhury, A.N. [Geco-Prakla, Inc., Houston, TX (United States)

    1994-12-31

    The distribution of upper Tertiary, sandstone-prone, deep-water sedimentary rocks from the vicinity of Cognac field, Mississippi Canyon (MC) 194, south of Mars field (MC763) is presented based on an integrated sequence stratigraphic analysis of seismic, well log, and biostratigraphic data. Paleo-salt distributions were reconstructed by plotting the changing positions of depocenters on five isopach maps generated from six key sequence boundaries. Depositional trends, projected under allochthonous salt sheets, indicated subsalt prospectivity. Sixteen sequences were interpreted and subdivided into three lowstand depositional units (basin-floor fan, slope fan, and prograding wedge). Thirty isochron/seismic facies maps were made to reveal the stratigraphic pattern through the late Tertiary. During the early Miocene, a salt-rimmed syncline centered north of Mars field in MC455 accumulated sediments. The salt rim collapsed, creating a middle Miocene turtle structure. Middle-late Miocene sand-rich turbidites bypassed this structure and were deposited to the south around Mars field and beyond. At the same time, another depotrough 30 mi east of Mars field channeled deep-water sands to the MC730 area. A late Miocene-early Pliocene counterregional fault striking parallel to the shelf edge formed as salt evacuated the area on the south side of the Cognac (MC194) and Lena (MC280) fields. This fault trapped the Pliocene reservoir sandstones that produce in these fields. Sedimentation during the late Pliocene-early Pleistocene was very slow (0.2m/1,000 yr) and characterized by thin, stacked, condensed sections of hemipelagic shale. Since the mid-Pleistocene, the Mississippi River has supplied sediments to the Mississippi Canyon area that have induced salt deformation that has in turn affected recent sedimentation.

  11. Major structural controls on the distribution of pre-Tertiary rocks, Nevada Test Site vicinity, southern Nevada

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    Cole, J.C.

    1998-10-23

    The lateral and vertical distributions of Proterozoic and Paleozoic sedimentary rocks in southern Nevada are the combined products of original stratigraphic relationships and post-depositional faults and folds. This map compilation shows the distribution of the pre-Tertiary rocks in the region including and surrounding the Nevada Test Site. It is based on considerable new evidence from detailed geologic mapping, biostratigraphic control, sedimentological analysis, and a review of regional map relationships. Proterozoic and Paleozoic rocks of the region record paleogeographic transitions between continental shelf depositional environments on the east and deeper-water slope-facies depositional environments on the west. Middle Devonian and Mississippian sequences, in particular, show strong lateral facies variations caused by contemporaneous changes in the western margin of North America during the Antler orogeny. Sections of rock that were originally deposited in widely separated facies localities presently lie in close proximity. These spatial relationships chiefly result from major east- and southeast-directed thrusts that deformed the region in Permian or later time. Somewhat younger contractional structures are identified within two irregular zones that traverse the region. These folds and thrusts typically verge toward the west and northwest and overprint the relatively simple pattern of the older contractional terranes. Local structural complications are significant near these younger structures due to the opposing vergence and due to irregularities in the previously folded and faulted crustal section. Structural and stratigraphic discontinuities are identified on opposing sides of two north-trending fault zones in the central part of the compilation region north of Yucca Flat. The origin and significance of these zones are enigmatic because they are largely covered b Tertiary and younger deposits. These faults most likely results from significant lateral

  12. Uranium favorability of tertiary sedimentary rocks of the western Okanogan highlands and of the upper Columbia River valley, Washington

    International Nuclear Information System (INIS)

    Marjaniemi, D.K.; Robins, J.W.

    1975-08-01

    Tertiary sedimentary rocks in the northern portions of the western Okanogan highlands and in the upper Columbia River valley were investigated during a regional study to determine the favorability for potential uranium resources of the Tertiary sedimentary rocks of northeastern Washington. This project involved measurement and sampling of surface sections, collection of samples from isolated outcrops, and chemical and mineralogical analyses of samples. No portion of the project area of this report is rated of high or of medium favorability for potential uranium resources. Low favorability ratings are given to Oroville, Tonasket, and Pine Creek areas of the Okanogan River valley; to the Republic graben; and to the William Lakes, Colville, and Sheep Creek areas of the upper Columbia River valley. All these areas contain some fluvial, poorly sorted feldspathic or arkosic sandstones and conglomerates. These rocks are characterized by very low permeability and a consistently high siliceous matrix suggesting very low initial permeability. There are no known uranium deposits in any of these areas, and low level uranium anomalies are rare

  13. Preliminary study of the uranium favorability of Mesozoic intrusive and Tertiary volcanic and sedimentary rocks of the Central Mojave Desert, Kern and San Bernardino counties, California

    International Nuclear Information System (INIS)

    Leedom, S.H.; Kiloh, K.D.

    1978-02-01

    Numerous, small, low-grade, supergene uranium deposits are found in Tertiary volcanic and sedimentary rocks in the central Mojave Desert of southern California. Large thorium-to-uranium ratios in samples of Mesozoic intrusive rocks exposed in the area indicate that these rocks have been extensively weathered, eroded, and subsequently leached by ground waters, and that they may have been the primary source of uranium for the deposits. The uranium content of samples of volcanic intrusive and extrusive rocks is average for intermediate to silicic rocks, but samples of basalt flows in the area contain six times the average uranium content of mafic igneous rocks. Devitrified tuffs and tuffaceous sedimentary rocks, interbedded with calcareous units, are additional sources of uranium for supergene uranium deposits found in calcareous units. Uranium is also found in accessory minerals in a few Mesozoic quartz-rich pegmatite dikes. Uranium deposits in the central Mojave Desert have been formed by enrichment during diagenetic replacement of Tertiary carbonate rocks; by supergene enrichment along fractures, joints, and bedding planes in Tertiary volcanic and sedimentary rocks; during formation of Holocene caliche; and by deposition within hydrothermally altered shear zones. Within the area, the diagenetic replacement type of deposit has the greatest potential for large, low-grade uranium occurrences. The other type of uranium deposits are small, erratically distributed, and extensively covered by alluvium

  14. Paleomagnetism of Latest Cambrian-Early Ordovician and Latest Cretaceous-Early Tertiary rocks of the Florida Mountains, southwest New Mexico

    Science.gov (United States)

    Geissman, John W.; Jackson, Mike; Harlan, Steve S.; van der Voo, Rob

    1991-04-01

    Paleomagnetic investigations have been carried out on latest Cambrian to Early Ordovician alkaline intrusions, their contact intermediate to mafic composition metaigneous rocks, and overlying lower Paleozoic and early Tertiary strata in the Florida Mountains, southwestern New Mexico. A well-defined, predominantly normal polarity magnetization of high median destructive induction and high, usually discrete laboratory unblocking temperatures is isolated from sites in metaigneous rocks in contact with syenites exposed on the northwestern flank of this late Cenozoic uplift. Combinations of stable endpoint and planar data are used in data analysis at the site level (D = 262°, I = -30°, α95 = 10°, k = 12; N = 22 site means). In addition to the presence of reverse polarity magnetizations at two sites, the dispersion of site mean directions in these rocks (VGP angular standard deviation of 19.6°) suggests that considerable variation of the geomagnetic field has been averaged. After correction for a combination of early Tertiary (Laramide) deformation and late Tertiary Basin-Range block tilting, this magnetization gives a paleomagnetic pole at 6°S, 169°E and is interpreted to have been acquired soon after intrusion of alkaline plutons at 503±10 Ma, based on published U-Pb zircon isotopic age determinations. A lack of well-defined, coherent magnetizations in the plutonic rocks may reflect the complex subsolidus alteration history of these rocks, as interpreted with Rb-Sr isotopic data. Hematitic sandstones of the earliest Ordovician Bliss Formation, which directly overlie the crystalline rocks in portions of the range, give dual-polarity magnetizations whose directions suggest that these rocks have probably been remagnetized; this remagnetization possibly occurred during deformation in late Cretaceous/Tertiary time. Ordovician carbonate rocks of the El Paso and Montoya formations give only a Holocene magnetization. Paleocene to earliest Eocene(?) hematite

  15. Uranium mineralization in tertiary volcanic rocks of the Los Frailes formation (Bolivia)

    International Nuclear Information System (INIS)

    Aparicio, A.

    1981-01-01

    The Los Frailes Formation, a 9000 km 2 area of Miocene-Pliocene age, contains uranium mineralization in acid tuffs, ignimbrites and lavas. Uranium also occurs in sedimentary rocks of various types and ages which outcrop in adjacent areas. So far the most extensive mineralization seems to be confined in volcanic pyroclastic rocks. Although the surface mineralization varies in grade from 0.01% to more than 2.5%, the average grade in the only deposit being mined (Cotaje) is 0.05% of U 3 O 8 . On the basis of the available data it is believed that certain leaching processes, during the last erosion cycle (Pliocene-Pleistocene) and under very humid conditions, brought about the mobilization of the uranium from the volcanic rocks in aqueous alkaline and calco-alkaline solutions circulating on the surface and underground. Uranium minerals were deposited, generally by chemical reduction, in tectonic zones and/or zones of high porosity. The common metallogenetic model in the western area, defined as the 'Sevaruyo uraniferous district', is exogenic and is characterized by epigenetic uranium occurrences and deposits formed by supergene enrichment. On the basis of their mechanism of formation, control of mineralization and mineral associations, these deposits are classified according to: those with strictly tectonic control, those with sedimentary control and those of mixed genetics. Recent discoveries in the eastern area of the volcanic complex give evidence of epigenetic mineralization, apparently linked with hypogene hydrothermal processes, in addition to exogenic mineralizations contained in rocks stratigraphically subjacent to the Los Frailes Formation. There is no intention of making an evaluation of the recently discovered resources since the studies and exploration are still at too early a stage to warrant prediction of their real potential. (author)

  16. Paleomagnetism of early Tertiary Alaska Peninsula rocks and implications for docking of peninsular terrane

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    Whitney, J.W.; Levinson, R.A.; Van Alstine, D.R.

    1985-04-01

    In order to refine the tectonic history of the peninsular terrane, Alaska, 22 sites (averaging 10 samples/site) in Paleogene Tertiary volcanic and sedimentary formations were sampled in the vicinity of Chignik, on the Pacific side of the Alaska Peninsula. Ten of the sites were drilled in the early Oligocene Meshik volcanics, ranging from andesite to basalt, and the other twelve sites were drilled in the late Eocene Tolstoi Formation sediments. Nine of the volcanic sites yielded stable R and/or N characteristic magnetization. Virtually no fine-grained, interbedded sediments occur with the Meshik volcanics at the sample sites, thus making reliable paleohorizontal determinations difficult. Although flow attitudes were tentatively used, it became rapidly apparent that problems of initial dip were insurmountable. As a result, all volcanic sites were considered unreliable for determining a meaningful paleomagnetic inclination. Upon thermal demagnetization, five of the sedimentary sites were judged stable. The mode of the paleomagnetic direction was calculated, D/I = 349.8/75.3(..beta..95 = 8.5), indicating no significant rotation. Uncertainties in structural corrections, however, may render only the inclination meaningful, which, from McFadden statistics yields, I = 75.9, ..cap alpha..95 = 7.9, corresponding to a paleolatitude of 63.3/sup 0/. This paleolatitude agrees with the expected value for the North American craton at 40 m.y. B.P., implying that the peninsular terrane had docked at at least that time.

  17. Geochemistry and tectonomagatic setting of Tertiary volcanic rocks of the Kangan area, northeast of Sarbisheh, southern Khorasan

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    Mahshid Malekian Dastjerdi

    2017-02-01

    Full Text Available Introduction The study area is located 12km away from the north east of Sarbisheh at the eastern border of the Lut block (Karimpour et al., 2011; Richards et al., 2012. The magmatic activity in the Lut blockhas begun in the middle Jurassic (165-162 Ma and reached its peak in the Tertiary age (Jung et al., 1983; Karimpour et al., 2011. Volcanic and subvolcanic rocks in the Tertiary age cover over half of the Lut block with up to 2000 m thickness and they were formed due to subduction prior to the collision of the Arabian and Asian plates (Jung et al., 1983; Karimpour et al., 2011. In the Kangan area, the basaltic lavas cropped out beyond the above intermediate to acid volcanic rocks. In this area, bentonite and perlite deposits have an economic importance. The main purpose of this paper is to present a better understanding of the tectono-magmatic settings of volcanic rocks in the northeast of Sarbisheh, east of Iran based on their geochemical characteristics. Materials and methods Fifteen samples were analyzed for major elements by inductively coupled plasma (ICP technologies and trace elements by using inductively coupled plasma mass spectrometry (ICP-MS, following a lithium metaborate/tetraborate fusion and nitric acid total digestion, at the Acme laboratories, Vancouver, Canada. Results The Kangan area is located at the northeast of Sarbishe, Southern Khorasan and the eastern border of the Lut block. In this area, basaltic lavas have cropped out above intermediate to acid lavas such as andesite, dacite, rhyolite (sometimes perlitic .The main minerals in the basalt are plagioclase, olivine and pyroxene, in andesite contain plagioclase, pyroxene, biotite and amphibole and in acid rocks include plagioclase, quartz, sanidine, biotite and amphibole. Intermediate to acid rocks have medium to high-K calc-alkaline nature and basalt is alkaline. Enrichment in LREE relative to HREE (Ce/Yb= 21.14-28.7, high ratio of Zr/Y(4.79- 10.81, enrichment in LILE

  18. Geology of drill hole UE25p No. 1: A test hole into pre-Tertiary rocks near Yucca Mountain, southern Nevada

    International Nuclear Information System (INIS)

    Carr, M.D.; Waddell, S.J.; Vick, G.S.; Stock, J.M.; Monsen, S.A.; Harris, A.G.; Cork, B.W.; Byers, F.M. Jr.

    1986-01-01

    Yucca Mountain in southern Nye County, Nevada, has been proposed as a potential site for the underground disposal of high-level nuclear waste. An exploratory drill hole designated UE25p No. 1 was drilled 3 km east of the proposed repository site to investigate the geology and hydrology of the rocks that underlie the Tertiary volcanic and sedimentary rock sequence forming Yucca Mountain. Silurian dolomite assigned to the Roberts Mountain and Lone Mountain Formations was intersected below the Tertiary section between a depth of approximately 1244 m (4080 ft) and the bottom of the drill hole at 1807 m (5923 ft). These formations are part of an important regional carbonate aquifer in the deep ground-water system. Tertiary units deeper than 1139 m (3733 ft) in drill hole UE25p No. 1 are stratigraphically older than any units previously penetrated by drill holes at Yucca Mountain. These units are, in ascending order, the tuff of Yucca Flat, an unnamed calcified ash-flow tuff, and a sequence of clastic deposits. The upper part of the Tertiary sequence in drill hole UE25p No. 1 is similar to that found in other drill holes at Yucca Mountain. The Tertiary sequence is in fault contact with the Silurian rocks. This fault between Tertiary and Paleozoic rocks may correlate with the Fran Ridge fault, a steeply westward-dipping fault exposed approximately 0.5 km east of the drill hole. Another fault intersects UE25p No. 1 at 873 m (2863 ft), but its surface trace is concealed beneath the valley west of the Fran Ridge fault. The Paintbrush Canyon fault, the trace of which passes less than 100 m (330 ft) east of the drilling site, intersects drill hole UE25p No. 1 at a depth of approximately 78 m (255 ft). The drill hole apparently intersected the west flank of a structural high of pre-Tertiary rocks, near the eastern edge of the Crater Flat structural depression

  19. Origin of a Tertiary oil from El Mahafir wildcat & geochemical correlation to some Muglad source rocks, Muglad basin, Sudan

    Science.gov (United States)

    Fadul Abul Gebbayin, Omer. I. M.; Zhong, Ningning; Ali Ibrahim, Gulfan; Ali Alzain, Mohamed

    2018-01-01

    Source rock screening analysis was performed on four stratigraphic units from the Muglad basin namely; Abu Gabra, Zarqa, Ghazal, and Baraka formations using pyrolysis and Vitrinite Reflectance (Ro). Results, integrated with the chromatographic and isotopic data from these rocks extracts and a Tertiary oil from El Mahafir-1 wild cat, were used to determine the origin of the oil. A good organic source within the Middle Abu Gabra Formation is observed in wells El Toor-6 and Neem Deep-1 (TOC, 1.0-2.0% & S2 5.0-10.0 mg C/g rock), with mixed kerogens I, II, & III, and thermally mature (% Ro = 0.74-0.94). The Campanian-Early Maastrichtian sequence, i.e. Zarqa and Ghazal formations are generally poor (TOC, TOC 1.8% & S2 5.0-10.0 mg C/g rock) and fair at Timsah-1 well (Avg. TOC 0.69% & S2 2.5-5.0 mg C/g rock) with a Kerogen that is predominantly Sapropellic at the former, and an exclusively Humic at the later. The formation is mature at Timsah (% Ro = 0.77-1.16) and early mature at El Mahafir-1 (% Ro = 0.64-0.81). Consistent with the pyrolysis, chromatographic data of the rock extracts confirms the mixed source nature of the Abu Gabra Formation which consists of both algal [prominent LMW n-alkanes & elevated C27 steranes (36-47%)], as well as terrigenous material [higher diasterane/regular sterane ratios (0.50-0.56), abundant rearranged hopanes, & relatively high CPIs (1.22-1.9)], accumulated in an oxic to sub-oxic environment (Pr/Ph, 1.3-3.0). Abu Gabra further shows low C29/C30 hopanes (0.45-0.54), low C28 steranes (21-26%) with high Gammacerane index (20.3). In contrast, the environment during the Late Cretaceous was strongly reducing (Pr/Ph, 0.37-1.0), associated with a wide organic diversity, both in space and time and is characterized by dominant algal input at some areas and or stratigraphic intervals [Elevated tricyclics, higher C29/C30 hopanes (0.5-1.14), and relatively low Gammacerane indices (4.6-14.4)], while mixed with abundant terrigenous material at others. A

  20. Preliminary study of the uranium potential of Tertiary rocks in the central San Juan Basin, New Mexico

    International Nuclear Information System (INIS)

    Vizcaino, H.P.; O'Neill, A.J.

    1977-12-01

    Three formations in the Tertiary of the San Juan Basin were investigated for their uranium favorability. They are the Ojo Alamo Sandstone, the Nacimiento Formation, and the San Jose Formation. The study comprised a literature survey and a basin analysis, which consisted of subsurface lithofacies, stratigraphic, and radiometric mapping. Field work in preparation for the subsurface analysis consisted of examination of outcrop and measured sections, surface radiometric traverses, and checking of reported surface radioactive anomalies. Interpretation of subsurface mapping provided the primary basis for favorability assessment. The sandstone trends depicted in lithofacies maps, and stratigraphic cross sections reflect large channel complexes and major fluvial systems originating in favorable source areas. Although surface radioactivity anomalies were found to be few, weak, and widespread, the San Juan Basin has abundant favorable host rocks. The subsurface anomalies, although weak, are widespread and sometimes persist throughout thickness intervals greater than 50 ft. Subsurface anomalies were mapped on a wide-spaced grid and are generalized. On the basis of apparent source, lithology, differential permeability, contents of carbonaceous detritus, and geometry, the Nacimiento Formation and the basal facies of the San Jose Formation in the north-central basin have the greatest potential. The Ojo Alamo Sandstone is less favorable, and the Nacimiento Formation in the southern part of the basin and the upper San Jose Formation are the least favorable of the units studied

  1. Geochemistry of middle Tertiary volcanic rocks in the northern Aquarius Mountains, west-central Arizona

    Energy Technology Data Exchange (ETDEWEB)

    Simmons, A.M.; Haxel, G.B.

    1993-04-01

    The northern Aquarius Mountains volcanic field ([approximately]50km east of Kingman) covers an area of 400 km[sup 2], bounded by upper Trout Creek (S), the Truxton Valley (N), the Big Sandy Valley (W), and Cross Mountain (E). The volcanic sequence rests upon a pre-middle Eocene erosional surface. The lowest units is a 250 m-thick unit of rhyolitic pyroclastic breccias and airfall tuffs. Successively younger units are: basanite flows and cinder cones; hornblende latite flows and domes; porphyritic dacite flows, domes, and breccias; alkali basalt intrusions; and low-silica rhyolite domes and small high=silica rhyolite flows. Dacite is volumetrically dominant, and erupted primarily from vents in and around Cedar Basin (Penitentiary Mtn 7.5[prime] quad.). Other geologists have obtained K-Ar dates [approximately]24--20 Ma for the basanites and latites. The alkali basalts, latites, dacites, and rhyolites evidently constitute a genetically-related high-K to shoshonitic calcalkaline suite with chemistry typical of subduction-related magmatism: enrichment in LILE and LREE, and depletion of Nb and Ta relative to K and La and of Ti relative to Hf and Yb. Each rock type is unique and distinguishable in K/Rb and Rb/Sr. The basanites are primitive (mg=0.75--0.78), have intraplate affinities (La/Nb[<=]1), and show consistent and distinctive depletion of K relative to the other LILE. The presence of these basanites in an early Miocene volcanic sequence is unusual or unexpected, as they predate (by [approximately]10 m.y.) the regional eruption of asthenosphere-derived basalts associated with Basin-and-Range extension.

  2. Undifferentiated Febrile Illness in Kathmandu, Nepal

    Science.gov (United States)

    Thompson, Corinne N.; Blacksell, Stuart D.; Paris, Daniel H.; Arjyal, Amit; Karkey, Abhilasha; Dongol, Sabina; Giri, Abhishek; Dolecek, Christiane; Day, Nick; Baker, Stephen; Thwaites, Guy; Farrar, Jeremy; Basnyat, Buddha

    2015-01-01

    Undifferentiated febrile illnesses (UFIs) are common in low- and middle-income countries. We prospectively investigated the causes of UFIs in 627 patients presenting to a tertiary referral hospital in Kathmandu, Nepal. Patients with microbiologically confirmed enteric fever (218 of 627; 34.8%) randomized to gatifloxacin or ofloxacin treatment were previously reported. We randomly selected 125 of 627 (20%) of these UFI patients, consisting of 96 of 409 (23%) cases with sterile blood cultures and 29 of 218 (13%) cases with enteric fever, for additional diagnostic investigations. We found serological evidence of acute murine typhus in 21 of 125 (17%) patients, with 12 of 21 (57%) patients polymerase chain reaction (PCR)-positive for Rickettsia typhi. Three UFI cases were quantitative PCR-positive for Rickettsia spp., two UFI cases were seropositive for Hantavirus, and one UFI case was seropositive for Q fever. Fever clearance time (FCT) for rickettsial infection was 44.5 hours (interquartile range = 26–66 hours), and there was no difference in FCT between ofloxacin or gatifloxacin. Murine typhus represents an important cause of predominantly urban UFIs in Nepal, and fluoroquinolones seem to be an effective empirical treatment. PMID:25667056

  3. Block Slides on Extremely Weak Tectonic Clay Seams in Openly Folded Tertiary Mud-Rocks at Auckland and the Rangitikei Valley, North Island, New Zealand

    Science.gov (United States)

    Prebble, Warwick M.; Williams, Ann L.

    2016-06-01

    Block slides have developed on extremely weak, thin clay seams of tectonic origin, parallel to bedding in gently dipping sandstones and mudstones of Tertiary age. Two areas of noted instability are investigated at Auckland and the Rangitikei valley. Dimensions range from 100 m across × 100 m long for short displacement block slides up to 4 km across × 3 km long for large landslide complexes in which block slides are a major component. Displacements of blocks range from incipient (cm) through short (30 m) to 2 or 3 km for large slides. Many of the Auckland slides are dormant but likely to move in a 2000 year return period earthquake or 100 year high intensity rain storm. At Rangitikei there are many active, younger slides. Sliding rates for active failures vary from a few cm/year to 50 m in 30 min. Host rocks are weak to very weak clayey sandstones and sandy mudstones. The seams are rich in smectite. They have polished and crushed walls, may have slickensides and some contain rounded rock fragments. Laboratory shear strength of the seams is 13 kPa cohesion and 13° friction, with a lower bound of 8° at zero cohesion. Strength is increased at the field scale by waviness, steps and splays. Continuity can be demonstrated over distances of hundreds of metres. Key investigation methods were mapping, shafts and trenches. Tectonic uplift, folding and faulting of the weak Tertiary strata and river down-cutting are perpetuating block slide development.

  4. Sub-crop geologic map of pre-Tertiary rocks in the Yucca Flat and northern Frenchman Flat areas, Nevada Test Site, southern Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Cole, J.C.; Harris, A.G.; Wahl, R.R.

    1997-10-02

    This map displays interpreted structural and stratigraphic relations among the Paleozoic and older rocks of the Nevada Test Site region beneath the Miocene volcanic rocks and younger alluvium in the Yucca Flat and northern Frenchman Flat basins. These interpretations are based on a comprehensive examination and review of data for more than 77 drillholes that penetrated part of the pre-Tertiary basement beneath these post-middle Miocene structural basins. Biostratigraphic data from conodont fossils were newly obtained for 31 of these holes, and a thorough review of all prior microfossil paleontologic data is incorporated in the analysis. Subsurface relationships are interpreted in light of a revised regional geologic framework synthesized from detailed geologic mapping in the ranges surrounding Yucca Flat, from comprehensive stratigraphic studies in the region, and from additional detailed field studies on and around the Nevada Test Site. All available data indicate the subsurface geology of Yucca Flat is considerably more complicated than previous interpretations have suggested. The western part of the basin, in particular, is underlain by relics of the eastward-vergent Belted Range thrust system that are folded back toward the west and thrust by local, west-vergent contractional structures of the CP thrust system. Field evidence from the ranges surrounding the north end of Yucca Flat indicate that two significant strike-slip faults track southward beneath the post-middle Miocene basin fill, but their subsurface traces cannot be closely defined from the available evidence. In contrast, the eastern part of the Yucca Flat basin is interpreted to be underlain by a fairly simple north-trending, broad syncline in the pre-Tertiary units. Far fewer data are available for the northern Frenchman Flat basin, but regional analysis indicates the pre-Tertiary structure there should also be relatively simple and not affected by thrusting. This new interpretation has implications

  5. Sub-crop geologic map of pre-Tertiary rocks in the Yucca Flat and northern Frenchman Flat areas, Nevada Test Site, southern Nevada

    Science.gov (United States)

    Cole, James C.; Harris, Anita G.; Wahl, Ronald R.

    1997-01-01

    This map displays interpreted structural and stratigraphic relations among the Paleozoic and older rocks of the Nevada Test Site region beneath the Miocene volcanic rocks and younger alluvium in the Yucca Flat and northern Frenchman Flat basins. These interpretations are based on a comprehensive examination and review of data for more than 77 drillholes that penetrated part of the pre-Tertiary basement beneath these post-middle Miocene structural basins. Biostratigraphic data from conodont fossils were newly obtained for 31 of these holes, and a thorough review of all prior microfossil paleontologic data is incorporated in the analysis. Subsurface relationships are interpreted in light of a revised regional geologic framework synthesized from detailed geologic mapping in the ranges surrounding Yucca Flat, from comprehensive stratigraphic studies in the region, and from additional detailed field studies on and around the Nevada Test Site.All available data indicate the subsurface geology of Yucca Flat is considerably more complicated than previous interpretations have suggested. The western part of the basin, in particular, is underlain by relics of the eastward-vergent Belted Range thrust system that are folded back toward the west and thrust by local, west-vergent contractional structures of the CP thrust system. Field evidence from the ranges surrounding the north end of Yucca Flat indicate that two significant strike-slip faults track southward beneath the post-middle Miocene basin fill, but their subsurface traces cannot be closely defined from the available evidence. In contrast, the eastern part of the Yucca Flat basin is interpreted to be underlain by a fairly simple north-trending, broad syncline in the pre-Tertiary units. Far fewer data are available for the northern Frenchman Flat basin, but regional analysis indicates the pre- Tertiary structure there should also be relatively simple and not affected by thrusting.This new interpretation has implications

  6. Sub-crop geologic map of pre-Tertiary rocks in the Yucca Flat and northern Frenchman Flat areas, Nevada Test Site, southern Nevada

    International Nuclear Information System (INIS)

    Cole, J.C.; Harris, A.G.; Wahl, R.R.

    1997-01-01

    This map displays interpreted structural and stratigraphic relations among the Paleozoic and older rocks of the Nevada Test Site region beneath the Miocene volcanic rocks and younger alluvium in the Yucca Flat and northern Frenchman Flat basins. These interpretations are based on a comprehensive examination and review of data for more than 77 drillholes that penetrated part of the pre-Tertiary basement beneath these post-middle Miocene structural basins. Biostratigraphic data from conodont fossils were newly obtained for 31 of these holes, and a thorough review of all prior microfossil paleontologic data is incorporated in the analysis. Subsurface relationships are interpreted in light of a revised regional geologic framework synthesized from detailed geologic mapping in the ranges surrounding Yucca Flat, from comprehensive stratigraphic studies in the region, and from additional detailed field studies on and around the Nevada Test Site. All available data indicate the subsurface geology of Yucca Flat is considerably more complicated than previous interpretations have suggested. The western part of the basin, in particular, is underlain by relics of the eastward-vergent Belted Range thrust system that are folded back toward the west and thrust by local, west-vergent contractional structures of the CP thrust system. Field evidence from the ranges surrounding the north end of Yucca Flat indicate that two significant strike-slip faults track southward beneath the post-middle Miocene basin fill, but their subsurface traces cannot be closely defined from the available evidence. In contrast, the eastern part of the Yucca Flat basin is interpreted to be underlain by a fairly simple north-trending, broad syncline in the pre-Tertiary units. Far fewer data are available for the northern Frenchman Flat basin, but regional analysis indicates the pre-Tertiary structure there should also be relatively simple and not affected by thrusting. This new interpretation has implications

  7. Undifferentiated embryonal sarcoma of liver

    Directory of Open Access Journals (Sweden)

    Avyakta Kallam

    2015-12-01

    Full Text Available Undifferentiated embryonal sarcoma of the liver (UESL is a rare malignant hepatic tumor. A 47 year old male presented with symptoms of sour taste in his mouth, occasional nausea, indigestion and 15-pound weight loss over two months. He had an unremarkable upper gastrointestinal endoscopy. Imaging showed a large liver mass in the left hepatic lobe that was resected and then reported as UESL. He went on to develop lung metastases and was initially treated with doxorubicin and ifosfamide followed by switching of therapy to gemcitabine and docetaxel due to progression of disease. He had a good response after two cycles and went on to receive four more cycles, achieving stable disease. We can therefore conclude that the combination of gemcitabine and docetaxel is a potential therapeutic option for patients with UESL.

  8. Undifferentiated Embryonal Sarcoma of Liver.

    Science.gov (United States)

    Kallam, Avyakta; Krishnamurthy, Jairam; Kozel, Jessica; Shonka, Nicole

    2015-12-29

    Undifferentiated embryonal sarcoma of the liver (UESL) is a rare malignant hepatic tumor. A 47 year old male presented with symptoms of sour taste in his mouth, occasional nausea, indigestion and 15-pound weight loss over two months. He had an unremarkable upper gastrointestinal endoscopy. Imaging showed a large liver mass in the left hepatic lobe that was resected and then reported as UESL. He went on to develop lung metastases and was initially treated with doxorubicin and ifosfamide followed by switching of therapy to gemcitabine and docetaxel due to progression of disease. He had a good response after two cycles and went on to receive four more cycles, achieving stable disease. We can therefore conclude that the combination of gemcitabine and docetaxel is a potential therapeutic option for patients with UESL.

  9. Coeval Ar-40/Ar-39 ages of 65.0 million years ago from Chicxulub crater melt rock and Cretaceous-Tertiary boundary tektites

    Science.gov (United States)

    Swisher, Carl C., III; Grajales-Nishimura, Jose M.; Montanari, Alessandro; Margolis, Stanley V.; Claeys, Philippe; Alvarez, Walter; Renne, Paul; Cedillo-Pardo, Esteban; Maurrasse, Florentin J.-M. R.; Curtis, Garniss H.

    1992-01-01

    Ar-40/Ar-39 dating of drill-core samples of a glassy melt rock recovered from beneath a massive impact breccia contained with the 180-kilometer subsurface Chicxulub crater yields well-behaved incremental heating spectra with a mean plateau age of 64.98 +/- 0.05 million years ago (Ma). The glassy melt rock of andesitic composition was obtained from core 9 (1390 to 1393 meters) in the Chicxulub 1 well. The age of the melt rock is virtually indistinguishable from Ar-40/Ar-39 ages obtained on tektite glass from Beloc, Haiti, and Arroyo el Mimbral, northeastern Mexico, of 65.01 +/- 0.08 Ma (mean plateau age for Beloc) and 65.07 +/- 0.10 Ma (mean total fusion age for both sites). The Ar-40/Ar-39 ages, in conjunction with geochemical and petrological similarities, strengthen the suggestion that the Chicxulub structure is the source for the Haitian and Mexican tektites and is a viable candidate for the Cretaceous-Tertiary boundary impact site.

  10. Distribution of organic carbon and petroleum source rock potential of Cretaceous and lower Tertiary carbonates, South Florida Basin: preliminary results

    Science.gov (United States)

    Palacas, James George

    1978-01-01

    Analyses of 134 core samples from the South Florida Basin show that the carbonates of Comanchean age are relatively richer in average organic carbon (0.41 percent) than those of Coahuilan age (0.28 percent), Gulfian age (0.18 percent) and Paleocene age (0.20 percent). They are also nearly twice as rich as the average world, wide carbonate (average 0.24 percent). The majority of carbonates have organic carbons less than 0.30 percent but the presence of many relatively organic rich beds composed of highly bituminous, argillaceous, highly stylolitic, and algal-bearing limestones and dolomites accounts for the higher percentage of organic carbon in some of the stratigraphic units. Carbonate rocks that contain greater than 0.4 percent organic carbon and that might be considered as possible petroleum sources were noted in almost each subdivision of the Coahuilan and Comanchean Series but particularly the units of Fredericksburg 'B', Trinity 'A', Trinity 'F', and Upper Sunniland. Possible source rocks have been ascribed by others to the Lower Sunniland, but lack of sufficient samples precluded any firm assessment in this initial report. In the shallower section of the basin, organic-rich carbonates containing as much as 3.2 percent organic carbon were observed in the lowermost part of the Gulfian Series and carbonate rocks with oil staining or 'dead' and 'live oil' were noted by others in the uppermost Gulfian and upper Cedar Keys Formation. It is questionable whether these shallower rocks are of sufficient thermal maturity to have generated commercial oil. The South Florida basin is still sparsely drilled and produces only from the Sunniland Limestone at an average depth of 11,500 feet (3500 m). Because the Sunniland contains good reservoir rocks and apparently adequate source rocks, and because the success rate of new oil field discoveries has increased in recent years, the chances of finding additional oil reserves in the Sunniland are promising. Furthermore, the

  11. Can magnetic resonance imaging differentiate undifferentiated arthritis?

    DEFF Research Database (Denmark)

    Østergaard, Mikkel; Duer, Anne; Hørslev-Petersen, K

    2005-01-01

    A high sensitivity for the detection of inflammatory and destructive changes in inflammatory joint diseases makes magnetic resonance imaging potentially useful for assigning specific diagnoses, such as rheumatoid arthritis and psoriatic arthritis in arthritides, that remain undifferentiated after...... conventional clinical, biochemical and radiographic examinations. With recent data as the starting point, the present paper describes the current knowledge on magnetic resonance imaging in the differential diagnosis of undifferentiated arthritis....

  12. Digital surfaces and hydrogeologic data for the Mesozoic through early Tertiary rocks in the Southeastern Coastal Plain in parts of Mississippi, Alabama, Georgia, South Carolina, and Florida

    Science.gov (United States)

    Cannon, Debra M.; Bellino, Jason C.; Williams, Lester J.

    2012-01-01

    A digital dataset of hydrogeologic data for Mesozoic through early Tertiary rocks in the Southeastern Coastal Plain was developed using data from five U.S. Geological Survey (USGS) reports published between 1951 and 1996. These reports contain maps and data depicting the extent and elevation of the Southeast Coastal Plain stratigraphic and hydrogeologic units in Florida and parts of Mississippi, Alabama, Georgia, and South Carolina. The reports are: Professional Paper 1410-B (Renken, 1996), Professional Paper 1088 (Brown and others, 1979), Professional Paper 524-G (Applin and Applin, 1967), Professional Paper 447 (Applin and Applin, 1965), and Circular 91 (Applin, 1951). The digital dataset provides hydrogeologic data for the USGS Energy Resources Program assessment of potential reservoirs for carbon sequestration and for the USGS Groundwater Resource Program assessment of saline aquifers in the southeastern United States. A Geographic Information System (ArcGIS 9.3.1) was used to construct 33 digital (raster) surfaces representing the top or base of key stratigraphic and hydrogeologic units. In addition, the Geographic Information System was used to generate 102 geo-referenced scanned maps from the five reports and a geo-database containing structural and thickness contours, faults, extent polygons, and common features. The dataset also includes point data of well construction and stratigraphic elevations and scanned images of two geologic cross sections and a nomenclature chart.

  13. Detailed north-south cross section showing environments of deposition, organic richness, and thermal maturities of lower Tertiary rocks in the Uinta Basin, Utah

    Science.gov (United States)

    Johnson, Ronald C.

    2014-01-01

    The Uinta Basin of northeast Utah has produced large amounts of hydrocarbons from lower Tertiary strata since the 1960s. Recent advances in drilling technologies, in particular the development of efficient methods to drill and hydraulically fracture horizontal wells, has spurred renewed interest in producing hydrocarbons from unconventional low-permeability dolomite and shale reservoirs in the lacustrine, Eocene Green River Formation. The Eocene Green River Formation was deposited in Lake Uinta, a long-lived saline lake that occupied the Uinta Basin, the Piceance Basin to the east, and the intervening Douglas Creek arch. The focus of recent drilling activity has been the informal Uteland Butte member of the Green River Formation and to a much lesser extent the overlying R-0 oil shale zone of the Green River Formation. Initial production rates ranging from 500 to 1,500 barrels of oil equivalent per day have been reported from the Uteland Butte member from horizontal well logs that are as long as 4,000 feet (ft);. The cross section presented here extends northward from outcrop on the southern margin of the basin into the basin’s deep trough, located just south of the Uinta Mountains, and transects the area where this unconventional oil play is developing. The Monument Butte field, which is one of the fields located along this line of section, has produced hydrocarbons from conventional sandstone reservoirs in the lower part of the Green River Formation and underlying Wasatch Formation since 1981. A major fluvial-deltaic system entered Lake Uinta from the south, and this new line of section is ideal for studying the effect of the sediments delivered by this drainage on hydrocarbon reservoirs in the Green River Formation. The cross section also transects the Greater Altamont-Bluebell field in the deepest part of the basin, where hydrocarbons have been produced from fractured, highly overpressured marginal lacustrine and fluvial reservoirs in the Green River, Wasatch

  14. Stratigraphy, structure, and some petrographic features of Tertiary volcanic rocks in the USW G-2 drill hole, Yucca Mountain, Nye County, Nevada

    Science.gov (United States)

    Maldonado, Florian; Koether, S.L.

    1983-01-01

    A continuously cored drill hole designated as USW G-2, located at Yucca Mountain in southwestern Nevada, penetrated 1830.6 m of Tertiary volcanic strata composed of abundant silicic ash-flow tuffs, minor lava and flow breccias, and subordinate volcaniclastic rocks. The volcanic strata penetrated are comprised of the following in descending order: Paintbrush Tuff (Tiva Canyon Member, Yucca Mountain Member, bedded tuff, Pah Canyon Member, and Topopah Spring Member), tuffaceous beds of Calico Hills, Crater Flat Tuff (Prow Pass Member, Bullfrog Member, and Tram unit), lava and flow breccia (rhyodacitic), tuff of Lithic Ridge, bedded and ash-flow tuff, lava and flow breccia (rhyolitic, quartz latitic, and dacitic), bedded tuff, conglomerate and ash-flow tuff, and older tuffs of USW G-2. Comparison of unit thicknesses at USW G-2 to unit thicknesses at previously drilled holes at Yucca Mountain indicate the following: (1) thickening of the Paintbrush Tuff members and tuffaceous beds of Calico Hills toward the northern part of Yucca Mountain; (2) thickening of the Prow Pass Member but thinning of the Bullfrog Member and Tram unit; (3) thinning of the tuff of Lithic Ridge; (4) presence of approximately 280 m of lava and flow breccia not previously penetrated by any drill hole; and (5) presence of an ash-flow tuff unit at the bottom of the drill hole not previously intersected, apparently the oldest unit penetrated at Yucca Mountain to date. Petrographic features of some of the units include: (1) decrease in quartz and K-feldspar and increases in biotite and plagioclase with depth in the tuffaceous beds of Calico Hills; (2) an increase in quartz phenocrysts from the top to the bottom members of the Crater Flat Tuff; (3) a low quartz content in the tuff of Lithic Ridge, suggesting tapping of the magma chamber at quartz-poor levels; (4) a change in zeolitic alteration from heulandite to clinoptilolite to mordenite with increasing depth; (5) lavas characterized by a rhyolitic

  15. Uranium favorability of tertiary sedimentary rocks of the Pend Oreille River valley, Washington. [Measurement and sampling of surface sections, collection of samples from isolated outcrops, chemical and mineralogical analyses of samples, and examination of available water logs

    Energy Technology Data Exchange (ETDEWEB)

    Marjaniemi, D.K.; Robins, J.W.

    1975-08-01

    Tertiary sedimentary rocks in the Pend Oreille River valley were investigated in a regional study to determine the favorability for potential uranium resources of northeastern Washington. This project involved measurement and sampling of surface sections, collection of samples from isolated outcrops, chemical and mineralogical analyses of samples, and examination of available water well logs. The Box Canyon Dam area north of Ione is judged to have very high favorability. Thick-bedded conglomerates interbedded with sandstones and silty sandstones compose the Tiger Formation in this area, and high radioactivity levels are found near the base of the formation. Uranophane is found along fracture surfaces or in veins. Carbonaceous material is present throughout the Tiger Formation in the area. Part of the broad Pend Oreille valley surrounding Cusick, Washington, is an area of high favorability. Potential host rocks in the Tiger Formation, consisting of arkosic sandstones interbedded with radioactive shales, probably extend throughout the subsurface part of this area. Carbonaceous material is present and some samples contain high concentrations of uranium. In addition, several other possible chemical indicators were found. The Tiger-Lost Creek area is rated as having medium favorability. The Tiger Formation contains very hard, poorly sorted granite conglomerate with some beds of arkosic sandstone and silty sandstone. The granite conglomerate was apparently derived from source rocks having relatively high uranium content. The lower part of the formation is more favorable than the upper part because of the presence of carbonaceous material, anomalously high concentrations of uranium, and other possible chemical indicators. The area west of Ione is judged to have low favorability, because of the very low permeability of the rocks and the very low uranium content. (auth)

  16. Undifferentiated connective tissue dysplasia in adolescents

    Directory of Open Access Journals (Sweden)

    G. Yu. Kalayeva

    2014-01-01

    Full Text Available Objective: to study the spectrum and frequency of dysplasia-dependent and connective tissue dysplasia-associated disorders in adolescents. One hundred and ten 10-to-14-year-old pupils of one of the Leninsk-Kuznetsky schools were examined. The presence and degree of undifferentiated connective tissue dysplasia (UCTD were established according to the phenotypic characters; joint mobility was rated using the standard Beighton methods. The adolescents showed a high prevalence of the signs of UCTD whose degree corresponded to that of joint hypermobility. The latter was accompanied by joint pain in 89 (33,3% adolescents in the study group or concurrent with scoliosis in 77,8% and platypodia in 22,2%. In a control group (я=29, scoliosis and platypodia were 2 and 3,3 times rarer, respectively; complaints of arthralgia were absent. After 3 years, the number of adolescents with platypodia increased up to 33,3% in the study group and up to 10,3% in the control group; that of teenagers with scoliosis did up to 81,5and 41,4%, respectively. A larger number of adolescents with CTD were noted to have vegetovascular disorders, more commonly with parasympathotonia with insufficient autonomic performance support. A great difference was retained in the frequency of myopia and biliary dyskinesia and in the incidence of respiratory infections. Thus, the high prevalence of dysplasia-dependent disorders in adolescents suggests that there is a need for the early detection of the signs of CTD in children to timely implement a package of prevention and health-improvement measures.

  17. Noun-Verb Ambiguity in Chronic Undifferentiated Schizophrenia

    Science.gov (United States)

    Goldfarb, Robert; Bekker, Natalie

    2009-01-01

    This study investigated noun-verb retrieval patterns of 30 adults with chronic undifferentiated schizophrenia and 67 typical adults, to determine if schizophrenia affected nouns (associated with temporal lobe function) differently from verbs (associated with frontal lobe function). Stimuli were homophonic homographic homonyms, balanced according…

  18. Management of undifferentiated embryonal sarcoma of the liver in ...

    African Journals Online (AJOL)

    Background. Undifferentiated embryonal sarcoma of the liver (UESL) is a rare neoplasm, and the third-most common paediatric hepatic malignancy. However, no treatment guidelines exist. No randomised, controlled trials support specific combinations of therapy. Objective. To compare presentation and management of ...

  19. Undifferentiated pleomorphic sarcoma of the neck – A case report

    Directory of Open Access Journals (Sweden)

    Jane Peiwen Lim

    Full Text Available Undifferentiated pleomorphic sarcoma very rarely affect the neck. We report a case of a 62 year old man who presented with a right sided skin lump which he noticed after sustaining a neck contusion in a road traffic accident about one year ago. The initial CT and ultrasound scans of the lump were suggestive of a thrombosed varix. Clinical examination showed a hard skin nodule with signs of tethering. He underwent a wide excision of the skin nodule and the histology showed undifferentiated pleomorphic sarcoma with margins involved. He subsequently underwent another re-excision of margins and pectoralis major flap reconstruction. Following surgery, he was also prescribed adjuvant radiotherapy and he remains well about 12 months after follow up. The surgical management of undifferentiated pleomorphic sarcoma in the neck is challenging due to the proximity of critical neck structures and the need to obtain clear margins. Thus, adjuvant radiotherapy is often used to improve disease control. Keywords: Case report, Sarcoma, Margins, Surgery, Adjuvant radiotherapy

  20. Promoter DNA hypermethylation and gene repression in undifferentiated Arabidopsis cells.

    Directory of Open Access Journals (Sweden)

    María Berdasco

    Full Text Available Maintaining and acquiring the pluripotent cell state in plants is critical to tissue regeneration and vegetative multiplication. Histone-based epigenetic mechanisms are important for regulating this undifferentiated state. Here we report the use of genetic and pharmacological experimental approaches to show that Arabidopsis cell suspensions and calluses specifically repress some genes as a result of promoter DNA hypermethylation. We found that promoters of the MAPK12, GSTU10 and BXL1 genes become hypermethylated in callus cells and that hypermethylation also affects the TTG1, GSTF5, SUVH8, fimbrin and CCD7 genes in cell suspensions. Promoter hypermethylation in undifferentiated cells was associated with histone hypoacetylation and primarily occurred at CpG sites. Accordingly, we found that the process specifically depends on MET1 and DRM2 methyltransferases, as demonstrated with DNA methyltransferase mutants. Our results suggest that promoter DNA methylation may be another important epigenetic mechanism for the establishment and/or maintenance of the undifferentiated state in plant cells.

  1. Uranium favorability of tertiary sedimentary rocks of the western Okanogan highlands and of the upper Columbia River valley, Washington. [Measurement and sampling of surface sections, collection of samples from isolated outcrops, and chemical and mineralogical analyses of samples; no known uranium deposits

    Energy Technology Data Exchange (ETDEWEB)

    Marjaniemi, D.K.; Robins, J.W.

    1975-08-01

    Tertiary sedimentary rocks in the northern portions of the western Okanogan highlands and in the upper Columbia River valley were investigated during a regional study to determine the favorability for potential uranium resources of the Tertiary sedimentary rocks of northeastern Washington. This project involved measurement and sampling of surface sections, collection of samples from isolated outcrops, and chemical and mineralogical analyses of samples. No portion of the project area of this report is rated of high or of medium favorability for potential uranium resources. Low favorability ratings are given to Oroville, Tonasket, and Pine Creek areas of the Okanogan River valley; to the Republic graben; and to the William Lakes, Colville, and Sheep Creek areas of the upper Columbia River valley. All these areas contain some fluvial, poorly sorted feldspathic or arkosic sandstones and conglomerates. These rocks are characterized by very low permeability and a consistently high siliceous matrix suggesting very low initial permeability. There are no known uranium deposits in any of these areas, and low level uranium anomalies are rare.

  2. Solid as a rock

    International Nuclear Information System (INIS)

    Pincus, H.J.

    1984-01-01

    Recent technologic developments have required a more comprehensive approach to the behavior of rock mass or rock substance plus discontinuities than was adequate previously. This work considers the inherent problems in such operations as the storage of hot or cold fluids in caverns and aquifers, underground storage of nuclear waste, underground recovery of heat from hydrocarbon fuels, tertiary recovery of oil by thermal methods, rapid excavation of large openings at shallow to great depths and in hostile environments, and retrofitting of large structures built on or in rock. The standardization of methods for determining rock properties is essential to all of the activities described, for use not only in design and construction but also in site selection and post-construction monitoring. Development of such standards is seen as a multidisciplinary effort

  3. Survival Outcomes for Combined Modality Therapy for Sinonasal Undifferentiated Carcinoma.

    Science.gov (United States)

    Kuo, Phoebe; Manes, R Peter; Schwam, Zachary G; Judson, Benjamin L

    2017-01-01

    Objective Sinonasal undifferentiated carcinoma is a rare and aggressive malignancy of the nasal cavity and paranasal sinuses. Multi-institutional studies examining outcomes of combined modality treatment versus other treatment modalities have not been performed. The objective of our study was to present outcomes for multimodality therapy through use of the National Cancer Database. Study Design Retrospective cohort study. Setting National Cancer Database. Methods A total of 435 cases of SNUC diagnosed between 2004 and 2012 were identified. Kaplan-Meier analyses were performed to find 5-year cumulative survival rates. Multivariate Cox regression evaluated overall survival based on treatment when adjusting for other prognostic factors (age, primary site, sex, race, comorbidity, insurance, and TNM stage). Within the surgery + chemoradiotherapy group, survival analysis was also performed to compare outcomes for induction and adjuvant chemotherapy. Results The cumulative 5-year survival rate was 41.5%, and 36.1% of patients received surgery with chemoradiotherapy. In multivariate analysis, surgery + chemoradiotherapy was associated with significantly improved overall survival versus surgery + radiotherapy and radiotherapy but not significantly different from chemoradiotherapy. Within the surgery + chemoradiotherapy group, induction and adjuvant chemotherapy groups did not have associated differences in survival. Conclusion Combined modality therapy (chemoradiotherapy or surgery + chemoradiotherapy) is associated with improved survival outcomes versus other treatment modalities in patients with sinonasal undifferentiated carcinoma.

  4. Primary renal undifferentiated sarcoma as an infiltrative mass in a 12 year old boy

    International Nuclear Information System (INIS)

    Kim, Yong Hee; Kim, Myung Joon; Lee, Mi Jung; Kim, Se Hwa

    2015-01-01

    Undifferentiated sarcomas are rare tumors not classified into any sarcoma subtype. Due to their rarity, imaging findings of undifferentiated sarcomas are poorly characterized. The purpose of this report was to present imaging findings of a pathologically confirmed undifferentiated sarcoma originated from the left kidney of a 12-year-old boy. The mass was infiltrative involving the renal pelvis. It mimicked massive hilar lymphadenopathy with a preserved renal contour visible by both ultrasonography and CT. Renal vein thrombosis was also observed. Although undifferentiated sarcomas are rare, they should be considered in differential diagnosis of infiltrative renal masses with renal pelvis invasion in children

  5. Clinical and Endoscopic Features of Undifferentiated Gastric Cancer in Patients with Severe Atrophic Gastritis.

    Science.gov (United States)

    Kishino, Maiko; Nakamura, Shinichi; Shiratori, Keiko

    2016-01-01

    Differentiated gastric cancer generally develops in the atrophic gastric mucosa, although undifferentiated cancer is sometimes encountered in patients with severe atrophic gastritis. We characterized the endoscopic features of undifferentiated gastric cancer in patients with severe atrophic gastritis. Stage IA early gastric cancer was diagnosed in 501 patients who were admitted to our hospital between April 2003 and March 2012. The endoscopic and pathological findings were compared among 29 patients with undifferentiated cancer and severe atrophic gastritis, 104 patients with undifferentiated cancer and mild/moderate atrophic gastritis and 223 patients with well-differentiated cancer and severe atrophic gastritis. Endoscopic atrophic gastritis was classified according to the Kimura-Takemoto classification as no gastritis, C-1 and C-2 (mild), C-3 and O-1 (moderate) or O-2 and O-3 (severe). The tumors were larger and showed deeper mural invasion in the patients with undifferentiated cancer and severe atrophic gastritis than in those with well-differentiated cancer and severe gastritis or undifferentiated cancer and mild/moderate gastritis. On endoscopy, undifferentiated cancer associated with severe gastritis was often red in color. It is often difficult to diagnose early undifferentiated gastric cancer, especially in patients with severe atrophic gastritis. The present study characterized the important endoscopic features of such tumors.

  6. Bem Sex Role Inventory Undifferentiated Score: A Comparison of Sexual Dysfunction Patients with Sexual Offenders.

    Science.gov (United States)

    Dwyer, Margretta; And Others

    1988-01-01

    Examined Bem Sex Role undifferentiated scores on 93 male sex offenders as compared with 50 male sexually dysfunctional patients. Chi-square analyses revealed significant difference: offenders obtained undifferentiated scores more often than did sexual dysfunctional population. Concluded that Bem Sex Role Inventory is useful in identifying sexual…

  7. Rock fragmentation

    Energy Technology Data Exchange (ETDEWEB)

    Brown, W.S.; Green, S.J.; Hakala, W.W.; Hustrulid, W.A.; Maurer, W.C. (eds.)

    1976-01-01

    Experts in rock mechanics, mining, excavation, drilling, tunneling and use of underground space met to discuss the relative merits of a wide variety of rock fragmentation schemes. Information is presented on novel rock fracturing techniques; tunneling using electron beams, thermocorer, electric spark drills, water jets, and diamond drills; and rock fracturing research needs for mining and underground construction. (LCL)

  8. BCNT studies for application to the undifferentiated thyroid carcinoma

    International Nuclear Information System (INIS)

    Dagrosa, Maria A.; Viaggi, Mabel E.; Cabrini, Romulo L.; Juvenal, Guillermo J.; Pisarev, Mario A.; Garavaglia, Ricardo N.; Farias, Silvia S.; Belli, Carolina; Larripa, Irene; Gangitano, David

    2000-01-01

    Undifferentiated thyroid carcinoma (UTC) lacks an effective treatment. Boron neutron capture therapy (BNCT) is based on the selective uptake of 10 B-boronated compounds by some tumours, followed by irradiation with an appropriate neutron beam. The radioactive boron originated ( 11 B) decays releasing 7 Li, gamma rays and alpha particles, and these latter will destroy the tumour. In order to explore the possibility of applying BNCT to UTC we have studied the biodistribution of BPA. Animal Model: To develop an animal model of undifferentiated thyroid carcinoma (UTC), which may be useful to study of BNCT. The UTC human cell line ARO was implanted into the back of the nude mice. We performed successive passages in mouse after tumor culturing in order to obtain an animal model similar to the human tumor. We studied the kinetics and the tumoral histology, the capability to induce metastasis, the biokinetics of in vitro growth, as well as cytogenetic and molecular aspects. Histological specimens of tumor showed extensive viability with high mitotic activity. At 117 days, the tumors reached a size of 1700 mm 3 and showed a central necrotic portion with a thin layer of viable cells presence of micro metastasis could be observed in the lung. The kinetics of growth both in vivo and in vitro showed that when the number of passages in mouse increases the growth rate decreases. The cytogenetic and molecular studies did not show differences between the original line and the sublines that could explain this phenotypic change. Moreover, the cytogenetic studies proved that the ARO cell line and its sublines showed a complex clonal karyotype including structural alterations with deletions and translocations involving chromosomes 5, 7, 8, 9p, 11p, 17q 19p, and 20q that were consistent with earlier reported data in UTC. In vivo BNCT studies: ARO cells were transplanted into the scapular region of NIH nude mice, and after 2 weeks BPA (350 or 600 mg/kg bw) was injected via i.p. The

  9. Highly sensitive in vitro methods for detection of residual undifferentiated cells in retinal pigment epithelial cells derived from human iPS cells.

    Directory of Open Access Journals (Sweden)

    Takuya Kuroda

    Full Text Available Human induced pluripotent stem cells (hiPSCs possess the capabilities of self-renewal and differentiation into multiple cell types, and they are free of the ethical problems associated with human embryonic stem cells (hESCs. These characteristics make hiPSCs a promising choice for future regenerative medicine research. There are significant obstacles, however, preventing the clinical use of hiPSCs. One of the most obvious safety issues is the presence of residual undifferentiated cells that have tumorigenic potential. To locate residual undifferentiated cells, in vivo teratoma formation assays have been performed with immunodeficient animals, which is both costly and time-consuming. Here, we examined three in vitro assay methods to detect undifferentiated cells (designated an in vitro tumorigenicity assay: soft agar colony formation assay, flow cytometry assay and quantitative real-time polymerase chain reaction assay (qRT-PCR. Although the soft agar colony formation assay was unable to detect hiPSCs even in the presence of a ROCK inhibitor that permits survival of dissociated hiPSCs/hESCs, the flow cytometry assay using anti-TRA-1-60 antibody detected 0.1% undifferentiated hiPSCs that were spiked in primary retinal pigment epithelial (RPE cells. Moreover, qRT-PCR with a specific probe and primers was found to detect a trace amount of Lin28 mRNA, which is equivalent to that present in a mixture of a single hiPSC and 5.0×10⁴ RPE cells. Our findings provide highly sensitive and quantitative in vitro assays essential for facilitating safety profiling of hiPSC-derived products for future regenerative medicine research.

  10. Optimization of the application of BNCT to undifferentiated thyroid cancer

    International Nuclear Information System (INIS)

    Dagrosa, M.A.; Thomasz, L.; Longhino, J.

    2006-01-01

    The possible increase in BNCT efficacy for undifferentiated thyroid carcinoma (UTC) using BPA plus BOPP and nicotinamide (NA) as a radiosensitizer on the BNCT reaction was analyzed. In these studies nude mice were transplanted with the ARO cells and after 14 days they were treated as follows: 1) Control; 2) NCT (neutrons alone); 3) NCT plus NA (100 mg/kg bw/day for 3 days); 4) BPA (350 mg/kg bw) + neutrons; 5) BPA+ NA+ neutrons; 6) BPA+BOPP (60 mg/kg bw) + neutrons. The flux of hyperthermal neutrons was 2.8 10 8 during 85 min. Neutrons alone or with NA caused some tumor growth delay, while in the BPA, BPA+NA and BPA+BOPP groups a 100% halt of tumor growth was observed. When the initial tumor volume was 50 mm 3 or less a complete cure was found in BPA+NA (2/2); BPA (1/4); BPA+BOPP (7/7). After 90 days of complete regression, recurrence of tumor was observed in 2/2 BPA/NA (2/2) and BPA+BOPP (1/7). Caspase 3 activity was increased in BPA+NA (p<0.05 vs controls). BPA plus NA increased tumor apoptosis but only the combination of BPA+BOPP increased significantly BNCT efficiency. (author)

  11. Science Rocks!

    Science.gov (United States)

    Prestwich, Dorothy; Sumrall, Joseph; Chessin, Debby A.

    2010-01-01

    It all began one Monday morning. Raymond could not wait to come to large group. In his hand, he held a chunk of white granite he had found. "Look at my beautiful rock!" he cried. The rock was passed around and examined by each student. "I wonder how rocks are made?" wondered one student. "Where do they come from?"…

  12. Progression rate of ankylosing spondylitis in patients with undifferentiated spondyloarthritis

    Science.gov (United States)

    Xia, Qing; Fan, Dazhi; Yang, Xiao; Li, Xiaona; Zhang, Xu; Wang, Mengmeng; Xu, Shengqian; Pan, Faming

    2017-01-01

    Abstract Background: The idea that undifferentiated spondyloarthritis (uSpA) represents the early undifferentiated stage of ankylosing spondylitis (AS) and other well-defined SpA subtypes is well known. The gist of this study is to assess the rate estimate of patients with uSpA evolved to AS during long-term follow-up. Methods: A systematic search was implemented to identify pertinent articles. The primary outcome was the rate estimate that patients with uSpA fulfilling the diagnosis of AS according to the modified New York criteria during follow-up. The rate estimate and corresponding 95% confidence interval (95%CI) were pooled by the random-effects model in STATA 11.0 software. Meta-regression analyses were adopted to explore the sources of heterogeneity. The quality assessment was conducted by the National Institutes of Health Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies and the Begg test and the Egger test were applied to assess publication bias. Results: Sixteen papers were finally included in this study after screening 1299 citations. The pooled rate of patients with uSpA progression to AS synthesized from the 16 papers was 0.323 (95%CI 0.257–0.389). Subgroup analysis based on the length of follow-up showed that the rate at the time-point of 5, 8, and 10 years follow-up was 0.220 (95%CI 0.110–0.330), 0.291 (95%CI 0.257–0.325), and 0.399 (95%CI 0.190–0.608), respectively; while the rate in Asia, Europe, and Latin America was 0.367 (95%CI 0.282–0.452), 0.228 (95%CI 0.066–0.390), and 0.269 (95%CI 0.209–0.329), respectively. Meta-regression analysis indicated that the length of follow-up alone accounts for 45.23% of the total heterogeneity. Nearly half of the papers scored fair quality and none publication bias was identified based on the Begg test and the Egger test. Further, line chart describes an obviously increased trend for the patients with uSpA fulfilling the diagnosis of AS over time. Conclusion: The

  13. Spindle and Giant Cell Type Undifferentiated Carcinoma of the Proximal Bile Duct

    OpenAIRE

    Ide, Takao; Miyoshi, Atsushi; Kitahara, Kenji; Kai, Keita; Noshiro, Hirokazu

    2012-01-01

    Undifferentiated spindle and giant cell carcinoma is an extremely rare malignant neoplasm arising in the extrahepatic bile duct. We herein present the case of a 67-year-old male who developed an undifferentiated spindle and giant cell carcinoma of the proximal bile duct. A nodular infiltrating tumor was located at the proximal bile duct, resulting in obstructive jaundice. Histologically, the tumor was composed of mainly spindle-shaped and giant cells and showed positive immunoreactivity for b...

  14. Chlamydiae as etiologic agents in chronic undifferentiated spondylarthritis.

    Science.gov (United States)

    Carter, John D; Gérard, Hervé C; Espinoza, Luis R; Ricca, Louis R; Valeriano, Joanne; Snelgrove, Jessica; Oszust, Cynthia; Vasey, Frank B; Hudson, Alan P

    2009-05-01

    The majority of patients with Chlamydia-induced reactive arthritis do not present with the classic triad of arthritis, conjunctivitis/iritis, and urethritis. Moreover, acute chlamydial infections are often asymptomatic. The aim of the present study was to assess the prevalence of synovial Chlamydia trachomatis and Chlamydia pneumoniae infections in patients with chronic undifferentiated spondylarthritis (uSpA). Study patients met the European Spondylarthropathy Study Group criteria for SpA, without evidence of ankylosing spondylitis, psoriasis, inflammatory bowel disease, or preceding dysentery. Symptoms were present for >or=6 months. Each patient underwent a synovial biopsy; tissue and concomitantly obtained peripheral blood mononuclear cells (PBMCs) were analyzed by polymerase chain reaction (PCR) for C trachomatis and C pneumoniae DNA. Other data collected on the day of the biopsy included standard demographic information and medical history, including any known history of C trachomatis or C pneumoniae. Physical examination (including joint count, evaluation for dactylitis and/or enthesitis, and skin examination) and HLA-B27 typing were performed. Synovial tissue (ST) samples from 167 patients with osteoarthritis (OA) were used as controls. Twenty-six patients met the entry criteria and underwent synovial biopsy (25 knee, 1 wrist). Sixteen of them (62%) were positive for C trachomatis and/or C pneumoniae DNA (10 for C trachomatis, 4 for C pneumoniae, and 2 for both). PCR analysis of ST revealed the presence of Chlamydia significantly more frequently in patients with uSpA than in OA controls (P<0.0001). No specific clinical characteristics differentiated Chlamydia-positive from Chlamydia-negative patients. PBMCs from 4 of the 26 uSpA patients (15%) were positive for Chlamydia, and Chlamydia was found in ST from 2 of these 4 patients. No significant correlation between PCR positivity and HLA-B27 positivity was found. The frequency of Chlamydia-positive ST samples

  15. Study of acute undifferentiated fever cases and their etiologies in rural Konkan area of Maharashtra state

    Directory of Open Access Journals (Sweden)

    Patil S. N

    2016-08-01

    Full Text Available Background: Acute undifferentiated fever (AUF is a common cause for which the patients seek health care in India. It is region specific and has similar clinical presentation, with varied etiologies. Due to this it posses challenge to the diagnosis, treatment and public health. Majority of patients present with nondescript symptoms. Scrub typhus, Malaria, Enteric Fever, Dengue, Leptospirosis, Chikungunya, Spotted fever, Rickettsiosis, Hantavirus, Q fever, Brucellosis, Influenza and other bacterial infections are some of the common etiologies of AUF. The prevalence of local AUF etiologies helps to prioritize differential diagnosis and guide the treatment. The study aimed to find out the predominant AUF etiologies in the rural Konkan area of Maharashtra state in India. Materials and Methods: This prospective observational study was conducted at a tertiary care hospital on the samples received from District hospitals and Primary health centers from Sindhudurg District of Maharashtra state for the duration of October 2012 to January 2014. Patients with age 5years and with classical symptoms of febrile illness were included in the study. About 500 blood samples received were investigated for Malaria, Bacterial culture sensitivity, Leptospira culture, ELISA for scrub typhus, Brucella, Dengue and Leptospira and further evaluated for commonest region specific AUF etiology. Results: The study included 500 blood samples obtained from patients presenting with classical symptoms of AUF. Samples received from males showed highest number of positive cases amounting for 82.47% with majority of cases (83% cases in middle age group. The sero-positivity of samples accounted for 42.8%. Brucella was the most common cause of AUF (28.50% followed by Leptospira (27.10% and Scrub typhus (21.49%. Interestingly there were no positive cases of malaria and only 11.21% samples positive for Dengue which are considered as most common AUF etiologies and treated accordingly

  16. Recreating Rocks

    DEFF Research Database (Denmark)

    Posth, Nicole R

    2008-01-01

    Nicole Posth and colleagues spent a month touring South African rock formations in their quest to understand the origin of ancient iron and silicate layers.......Nicole Posth and colleagues spent a month touring South African rock formations in their quest to understand the origin of ancient iron and silicate layers....

  17. Tertiary Education in Poland

    OpenAIRE

    World Bank

    2004-01-01

    The polish tertiary education report was undertaken by the World Bank and the European Investment Bank in consultation with the Ministry of National Education and Sports of Poland (MoNES). The modernization of higher education and other tertiary education services has become an increasing focus of public concern in Poland. A major purpose of the report is to discuss important issues in Pol...

  18. Art Rocks with Rock Art!

    Science.gov (United States)

    Bickett, Marianne

    2011-01-01

    This article discusses rock art which was the very first "art." Rock art, such as the images created on the stone surfaces of the caves of Lascaux and Altimira, is the true origin of the canvas, paintbrush, and painting media. For there, within caverns deep in the earth, the first artists mixed animal fat, urine, and saliva with powdered minerals…

  19. Rock Physics

    DEFF Research Database (Denmark)

    Fabricius, Ida Lykke

    2017-01-01

    Rock physics is the discipline linking petrophysical properties as derived from borehole data to surface based geophysical exploration data. It can involve interpretation of both elastic wave propagation and electrical conductivity, but in this chapter focus is on elasticity. Rock physics is based...... on continuum mechanics, and the theory of elasticity developed for statics becomes the key to petrophysical interpretation of velocity of elastic waves. In practice, rock physics involves interpretation of well logs including vertical seismic profiling (VSP) and analysis of core samples. The results...

  20. Rock Foundations

    National Research Council Canada - National Science Library

    1994-01-01

    .... Chapter 4 provides guidance on rock mass characterization and classification schemes. Chapters 5 and 6 provide guidance on related topic areas of foundation deformation and settlement and foundation bearing capacity, respectively...

  1. Geological and geochemical variations in Mid-Tertiary Ethiopian ...

    African Journals Online (AJOL)

    The paper presents the results of a comprehensive major element, trace element, and Sr-Nd-Pb-Hf isotopic study of Mid-Tertiary volcanic sequences from the northwestern flood basalt province in Ethiopia. The volcanic rocks studied range in composition from basanites, alkaline basalts, and ankaramites, which form the 1st ...

  2. Ontogeny in Tertiary Frogs

    Czech Academy of Sciences Publication Activity Database

    Roček, Zbyněk

    2004-01-01

    Roč. 260, č. 3 (2004), s. 322-323 ISSN 0362-2525. [International Congress of Vertebrate Morphology /7./. 27.07.2004-01.08.2004, Boca Raton] Keywords : Anura * Tertiary * Czech Republic Subject RIV: EA - Cell Biology

  3. Secondary and tertiary hyperparathyroidism.

    Science.gov (United States)

    Jamal, Sophie A; Miller, Paul D

    2013-01-01

    We reviewed the etiology and management of secondary and tertiary hyperparathyroidism. Secondary hyperparathyroidism is characterized by an increase in parathyroid hormone (PTH) that is appropriate and in response to a stimulus, most commonly low serum calcium. In secondary hyperparathyroidism, the serum calcium is normal and the PTH level is elevated. Tertiary hyperparathyroidism is characterized by excessive secretion of PTH after longstanding secondary hyperparathyroidism, in which hypercalcemia has ensued. Tertiary hyperparathyroidism typically occurs in men and women with chronic kidney disease usually after kidney transplant. The etiology and treatment of secondary hyperparathyroidism is relatively straightforward whereas data on the management of tertiary hyperparathyroidism is limited to a few small trials with short follow-up. Copyright © 2013 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved.

  4. Gynecologic Cancer InterGroup (GCIG) consensus review for high-grade undifferentiated sarcomas of the uterus

    NARCIS (Netherlands)

    Pautier, Patricia; Nam, Eun Ji; Provencher, Diane M.; Hamilton, Anne L.; Mangili, Giorgia; Siddiqui, Nadeem Ahmad; Westermann, Anneke M.; Reed, Nicholas Simon; Harter, Philipp; Ray-Coquard, Isabelle

    2014-01-01

    High-grade undifferentiated sarcomas (HGUSs) are rare uterine malignancies arising from the endometrial stroma. They are poorly differentiated sarcomas composed of cells that do not resemble proliferative-phase endometrial stroma. High-grade undifferentiated sarcomas are characterized by aggressive

  5. FEATURES OF CLINICAL COURSE OF GASTROESOPHAGEAL REFLUX DISEASE IN NEWLY RECRUITED WITH CONNECTIVE TISSUE UNDIFFERENTIATED DYSPLASIA SYNDROME

    Directory of Open Access Journals (Sweden)

    E.I. Kashkina

    2008-12-01

    Full Text Available The presence of connective tissue undifferentiated dysplasia syndrome against a background of psychological stress at newly recruited can promote the risk of gastroesophageal reflux disease occurrence. To the utmost, correlation between the gastroesophageal reflux disease and such manifestations of connective tissue undifferentiated dysplasia syndrome as asthenic constitution, chest deformation, Gothic palate and hypermobility of joints was found

  6. Bone edema on magnetic resonance imaging is an independent predictor of rheumatoid arthritis development in patients with early undifferentiated arthritis

    DEFF Research Database (Denmark)

    Duer-Jensen, Anne; Hørslev-Petersen, Kim; Hetland, Merete Lund

    2011-01-01

    To study magnetic resonance imaging (MRI) as a tool for early diagnosis of rheumatoid arthritis (RA) in patients with early undifferentiated arthritis (UA).......To study magnetic resonance imaging (MRI) as a tool for early diagnosis of rheumatoid arthritis (RA) in patients with early undifferentiated arthritis (UA)....

  7. Algorithm for identification of undifferentiated peripheral inflammatory arthritis: a multinational collaboration through the 3e initiative

    NARCIS (Netherlands)

    Hazlewood, Glen; Aletaha, Daniel; Carmona, Loreto; Landewé, Robert B. M.; van der Heijde, Désirée M.; Bijlsma, Johannes W. J.; Bykerk, Vivian P.; Canhão, Helena; Catrina, Anca I.; Durez, Patrick; Edwards, Christopher J.; Leeb, Burkhard F.; Mjaavatten, Maria D.; Martinez-Osuna, Pindaro; Montecucco, Carlomaurizio; Ostergaard, Mikkel; Serra-Bonett, Natali; Xavier, Ricardo M.; Zochling, Jane; Machado, Pedro; Thevissen, Kristof; Vercoutere, Ward; Bombardier, Claire

    2011-01-01

    To develop an algorithm for identification of undifferentiated peripheral inflammatory arthritis (UPIA). An algorithm for identification of UPIA was developed by consensus during a roundtable meeting with an expert panel. It was informed by systematic reviews of the literature used to generate 10

  8. Imaging features of undifferentiated embryonal sarcoma of the liver: a series of 15 children

    International Nuclear Information System (INIS)

    Gabor, Flaviu; Franchi-Abella, Stephanie; Pariente, Daniele; Merli, Laura; Adamsbaum, Catherine

    2016-01-01

    Undifferentiated embryonal sarcoma of the liver is a rare malignant mesenchymal tumour occurring mostly in children ages 6-10 years. The discrepancy between its solid appearance on US and cystic-like appearance on CT has been described. To study the imaging particularities and similarities among our cases of undifferentiated embryonal sarcoma and to report the errors in initial diagnoses. We conducted a retrospective study of 15 children with undifferentiated embryonal sarcoma diagnosed or referred to our hospital during 1997-2015 and analysed the clinical, biological and imaging data. We identified eight boys and seven girls ages 9 months to 14 years. Ten children presented with abdominal pain. Alpha-fetoprotein was slightly increased in one. Initial US and CT had been performed for all, while additional MRI had been done in two children. Initial CT demonstrated a hypoattenuated mass in all. Rupture was seen in five and intratumoural bleeding in seven children. Tumour volumes reduced during neoadjuvant chemotherapy in 10 children. Undifferentiated embryonal sarcoma might be suggested in a non-secreting unifocal tumour with well-defined borders, fluid-filled spaces on US, hypoattenuation and serpiginous vessels on CT, and if there are signs of internal bleeding or rupture on CT or MRI. (orig.)

  9. Undifferentiated Embryonic Cell Transcription Factor 1 Regulates ESC Chromatin Organization and Gene Expression

    NARCIS (Netherlands)

    Kooistra, Susanne M.; van den Boom, Vincent; Thummer, Rajkumar P.; Johannes, Frank; Wardenaar, Rene; Tesson, Bruno M.; Veenhoff, Liesbeth M.; Fusetti, Fabrizia; O'Neill, Laura P.; Turner, Bryan M.; de Haan, Gerald; Eggen, Bart J. L.; O’Neill, Laura P.

    2010-01-01

    Previous reports showed that embryonic stem (ES) cells contain hyperdynamic and globally transcribed chromatin-properties that are important for ES cell pluripotency and differentiation. Here, we demonstrate a role for undifferentiated embryonic cell transcription factor 1 (UTF1) in regulating ES

  10. Azathioprine-induced shock in a patient suffering from undifferentiated erosive oligoarthritis

    NARCIS (Netherlands)

    Demirtaş-Ertan, G.; Rowshani, A. T.; ten Berge, I. J. M.

    2006-01-01

    Shock due to a hypersensitivity response to azathioprine is unpredictable, occurs seldom and bears a potentially fatal outcome. Azathioprine is widely used in the treatment of autoimmune diseases and in solid organ transplantation. Here, we present a patient who suffered from undifferentiated

  11. Imaging features of undifferentiated embryonal sarcoma of the liver: a series of 15 children

    Energy Technology Data Exchange (ETDEWEB)

    Gabor, Flaviu; Franchi-Abella, Stephanie; Pariente, Daniele [Bicetre Hospital, Department of Pediatric Radiology, Le Kremlin-Bicetre (France); Merli, Laura [Bambino Gesu Children' s Hospital, Unit of Hepato-Biliary and Transplant Surgery, Department of Surgery and Transplantation Centre, Rome (Italy); Adamsbaum, Catherine [Bicetre Hospital, Department of Pediatric Radiology, Le Kremlin-Bicetre (France); Paris Sud University, Faculty of Medicine, Le Kremlin-Bicetre (France); Universite Paris-Saclay, LTCI, CNRS, Telecom Paris Tech, Paris (France)

    2016-11-15

    Undifferentiated embryonal sarcoma of the liver is a rare malignant mesenchymal tumour occurring mostly in children ages 6-10 years. The discrepancy between its solid appearance on US and cystic-like appearance on CT has been described. To study the imaging particularities and similarities among our cases of undifferentiated embryonal sarcoma and to report the errors in initial diagnoses. We conducted a retrospective study of 15 children with undifferentiated embryonal sarcoma diagnosed or referred to our hospital during 1997-2015 and analysed the clinical, biological and imaging data. We identified eight boys and seven girls ages 9 months to 14 years. Ten children presented with abdominal pain. Alpha-fetoprotein was slightly increased in one. Initial US and CT had been performed for all, while additional MRI had been done in two children. Initial CT demonstrated a hypoattenuated mass in all. Rupture was seen in five and intratumoural bleeding in seven children. Tumour volumes reduced during neoadjuvant chemotherapy in 10 children. Undifferentiated embryonal sarcoma might be suggested in a non-secreting unifocal tumour with well-defined borders, fluid-filled spaces on US, hypoattenuation and serpiginous vessels on CT, and if there are signs of internal bleeding or rupture on CT or MRI. (orig.)

  12. Pleomorphic undifferentiated sarcoma of urinary bladder with calcified pulmonary metastasis: A rare entity

    Directory of Open Access Journals (Sweden)

    Prasad Mylarappa

    2013-01-01

    Full Text Available We report the case of a 29-year-old male who presented to us with hematuria, dysuria and bilateral flank pain. On evaluation, the patient was found to have primary pleomorphic undifferentiated sarcoma of bladder with calcified pulmonary metastasis, confirmed with computerized tomography scan and immunohistochemistry.

  13. Acute undifferentiated fever in Binh Thuan province, Vietnam: imprecise clinical diagnosis and irrational pharmaco-therapy

    NARCIS (Netherlands)

    Phuong, Hoang L.; de Vries, Peter J.; Nagelkerke, Nico; Giao, Phan T.; Hung, Le Q.; Binh, Tran Q.; Nga, Tran T. Thanh; Nam, Nguyen V.; Kager, Piet A.

    2006-01-01

    OBJECTIVES: To describe the characteristics of patients consulting commune primary healthcare posts for acute undifferentiated fever not being malaria (AUF), and to explore the diagnostic and therapeutic responses of the healthcare workers. METHODS: All patients presenting with AUF at 12 commune

  14. Long-term culture of undifferentiated spermatogonia isolated from immature and adult bovine testes.

    Science.gov (United States)

    Suyatno; Kitamura, Yuka; Ikeda, Shuntaro; Minami, Naojiro; Yamada, Masayasu; Imai, Hiroshi

    2018-03-01

    Undifferentiated spermatogonia eventually differentiate in the testis to produce haploid sperm. Within this cell population, there is a small number of spermatogonial stem cells (SSCs). SSCs are rare cells in the testis, and their cellular characteristics are poorly understood. Establishment of undifferentiated cell line would provide an indispensable tool for studying their biological nature and spermiogenesis/spermatogenesis in vitro. However, there have been few reports on the long-term culture of undifferentiated spermatogonia in species other than rodents. Here, we report the derivation and long-term in vitro culture of undifferentiated spermatogonia cell lines from immature and adult bovine testes. Cell lines from immature testes were maintained in serum-free culture conditions in the presence of glial-cell-line-derived neurotropic factor (GDNF) and bovine leukemia inhibitory factor (bLIF). These cell lines have embryonic stem (ES)-like cell morphology, express pluripotent-stem-cell-specific and germ-cell-specific markers at the protein and mRNA levels, and contributed to the inner cell mass (ICM) of embryos in the blastocyst stage. Meanwhile, cell lines established from adult testes were maintained in low-serum media in the presence of 6-bromoindirubin-3'-oxime (BIO). These cell lines have characteristics resembling those of previously reported male mouse germ cell lines as confirmed by their botryoidally aggregated morphology, as well as the expression of germ-cell-specific markers and pluripotent stem cell markers. These findings could be useful for the development of long-term culture of undifferentiated spermatogonia, which could aid in conservation of species and improvement of livestock production through genome editing technology. © 2018 Wiley Periodicals, Inc.

  15. Possibility of Undifferentiated Human Thigh Adipose Stem Cells Differentiating into Functional Hepatocytes

    Directory of Open Access Journals (Sweden)

    Jong Hoon Lee

    2012-11-01

    Full Text Available BackgroundThis study aimed to investigate the possibility of isolating mesenchymal stem cells (MSCs from human thigh adipose tissue and the ability of human thigh adipose stem cells (HTASCs to differentiate into hepatocytes.MethodsThe adipose-derived stem cells (ADSCs were isolated from thigh adipose tissue. Growth factors, cytokines, and hormones were added to the collagen coated dishes to induce the undifferentiated HTASCs to differentiate into hepatocyte-like cells. To confirm the experimental results, the expression of hepatocyte-specific markers on undifferentiated and differentiated HTASCs was analyzed using reverse transcription polymerase chain reaction and immunocytochemical staining. Differentiation efficiency was evaluated using functional tests such as periodic acid schiff (PAS staining and detection of the albumin secretion level using enzyme-linked immunosorbent assay (ELISA.ResultsThe majority of the undifferentiated HTASCs were changed into a more polygonal shape showing tight interactions between the cells. The differentiated HTASCs up-regulated mRNA of hepatocyte markers. Immunocytochemical analysis showed that they were intensely stained with anti-albumin antibody compared with undifferentiated HTASCs. PAS staining showed that HTASCs submitted to the hepatocyte differentiation protocol were able to more specifically store glycogen than undifferentiated HTASCs, displaying a purple color in the cytoplasm of the differentiated HTASCs. ELISA analyses showed that differentiated HTASCs could secrete albumin, which is one of the hepatocyte markers.ConclusionsMSCs were islolated from human thigh adipose tissue differentiate to heapatocytes. The source of ADSCs is not only abundant abdominal adipose tissue, but also thigh adipose tissue for cell therapy in liver regeneration and tissue regeneration.

  16. Source rock

    Directory of Open Access Journals (Sweden)

    Abubakr F. Makky

    2014-03-01

    Full Text Available West Beni Suef Concession is located at the western part of Beni Suef Basin which is a relatively under-explored basin and lies about 150 km south of Cairo. The major goal of this study is to evaluate the source rock by using different techniques as Rock-Eval pyrolysis, Vitrinite reflectance (%Ro, and well log data of some Cretaceous sequences including Abu Roash (E, F and G members, Kharita and Betty formations. The BasinMod 1D program is used in this study to construct the burial history and calculate the levels of thermal maturity of the Fayoum-1X well based on calibration of measured %Ro and Tmax against calculated %Ro model. The calculated Total Organic Carbon (TOC content from well log data compared with the measured TOC from the Rock-Eval pyrolysis in Fayoum-1X well is shown to match against the shale source rock but gives high values against the limestone source rock. For that, a new model is derived from well log data to calculate accurately the TOC content against the limestone source rock in the study area. The organic matter existing in Abu Roash (F member is fair to excellent and capable of generating a significant amount of hydrocarbons (oil prone produced from (mixed type I/II kerogen. The generation potential of kerogen in Abu Roash (E and G members and Betty formations is ranging from poor to fair, and generating hydrocarbons of oil and gas prone (mixed type II/III kerogen. Eventually, kerogen (type III of Kharita Formation has poor to very good generation potential and mainly produces gas. Thermal maturation of the measured %Ro, calculated %Ro model, Tmax and Production index (PI indicates that Abu Roash (F member exciting in the onset of oil generation, whereas Abu Roash (E and G members, Kharita and Betty formations entered the peak of oil generation.

  17. Rocking pneumonia.

    Science.gov (United States)

    Rijkers, Ger T; Rodriguez Gomez, Maria

    2017-01-01

    Ever since Chuck Berry coined the term "rocking pneumonia" in his 1956 song "Roll over Beethoven", pneumonia has been mentioned frequently in modern blues and rock songs. We analyzed the lyrics of these songs to examine how various elements of pneumonia have been represented in popular music, specifically the cause of pneumonia, the risk groups, comorbidity (such as the boogie woogie flu), the clinical symptoms, and treatment and outcome. Up to this day, songwriters suggest that pneumonia is caused mainly by the cold and rain and that treatment is hardly possible, aside from a shot of rhythm and blues.

  18. Intellektuaalne rock

    Index Scriptorium Estoniae

    2007-01-01

    Briti laulja-helilooja ja näitleja Toyah Willcox ning Bill Rieflin ansamblist R.E.M. ja Pat Mastelotto King Krimsonist esinevad koos ansamblitega The Humans ja Tuner 25. okt. Tallinnas Rock Cafés ja 27. okt Tartu Jaani kirikus

  19. Igneous Rocks

    Science.gov (United States)

    Doe, Bruce R.

    “Igneous Rocks was written for undergraduate geology majors who have had a year of college-level chemistry and a course in mineralogy … and for beginning graduate students. Geologists working in industry, government, or academia should find this text useful as a guide to the technical literature up to 1981 and as an overview of topics with which they have not worked but which may have unanticipated pertinence to their own projects.” So starts the preface to this textbook.As one who works part time in research on igneous rocks, especially as they relate to mineral deposits, I have been looking for such a book with this avowed purpose in a field that has a choking richness of evolving terminology and a bewildering volume of interdisciplinary literature. In addition to the standard topics of igneous petrology, the book contains a chapter on the role of igneous activity in the genesis of mineral deposits, its value to geothermal energy, and the potential of igneous rocks as an environment for nuclear waste disposal. These topics are presented rather apologetically in the preface, but the author is to be applauded for including this chapter. The apology shows just how new these interests are to petrology. Recognition is finally coming that, for example, mineral deposits are not “sports of nature,” a view held even by many economic geologists as recently as the early 1960's; instead they are perfectly ordinary geochemical features formed by perfectly ordinary geologic processes. In fact, the mineral deposits and their attendant alteration zones probably have as much to tell us about igneous rocks as the igneous rocks have to tell us about mineral deposits.

  20. White Rock

    Science.gov (United States)

    2005-01-01

    14 November 2005 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a portion of the famous 'White Rock' feature in Pollack Crater in the Sinus Sabaeus region of Mars. The light-toned rock is not really white, but its light tone caught the eye of Mars geologists as far back as 1972, when it was first spotted in images acquired by Mariner 9. The light-toned materials are probably the remains of a suite of layered sediments that once spread completely across the interior of Pollack Crater. Dark materials in this image include sand dunes and large ripples. Location near: 8.1oS, 335.1oW Image width: width: 3 km (1.9 mi) Illumination from: lower left Season: Southern Summer

  1. Primary Pleomorphic Undifferentiated Sarcoma—a Rare Renal Localization: A Case Report

    Directory of Open Access Journals (Sweden)

    Soufiane Mellas

    2012-01-01

    Full Text Available Undifferentiated pleomorphic sarcoma is known as a soft tissue sarcoma. Very few cases of this tumor originating from the renal parenchyma or renal capsule have been reported. We report a case of a 70-year-old patient admitted for enormous ureterohydronephrosis and pyelonephritis due to a pelvic ureter lithiasis. After draining by ureteral double J catheter, a nephroureterectomy was performed for nonfunctional kidney confirmed by scintigraphy. The histopathological study shows a pleomorphic undifferentiated sarcoma. The patient was sent to oncologists. Chemotherapy was proposed but the family decided to stop the treatment. The patient passed away 10 months later. Clinicians and pathologists should be aware of the very low occurrence of this renal tumor, which is extremely rare. Currently there is no consensus about its management. Our case extends the literature concerning this tumor.

  2. Primary CNS anaplastic diffuse large B-cell lymphoma mimicking undifferentiated metastatic tumors: a case report.

    Science.gov (United States)

    Yang, Tianyu; Belverud, Shawn; Yeh, Albert Y; Bandovic, Jela; Farmer, Peter; Woldenberg, Rona F; Demopoulos, Alexis; Schulder, Michael; Li, Jian Yi

    2010-02-01

    Primary central nervous system lymphoma (PCNSL) is a rare intracranial tumor, with an annual incidence of six per million population. Anaplastic variant of primary CNS diffuse large B-cell lymphoma is less common; to our knowledge, there is only one other case report in the world literature. We describe a 71 year old immunocompetent female without significant past medical history who presented with confusion and a homogeneously enhancing midline mass. The patient underwent craniotomy for tumor biopsy, followed by high-dose methotrexate-based chemotherapy despite a remarkably low performance status. Histologically, this tumor was composed of undifferentiated polymorphic tumor cells, multi-nucleated giant cells, extensive necrosis, and conspicuous mitotic activity, mimicking undifferentiated metastatic tumors. Immunohistochemical stains demonstrated immunopositivity of tumor cells for CD20, MUM-1, and BCL-6, and negative staining for CD3, CD10, and CD30. The clinical course, diagnostic workup, pathologic correlates, and treatment outcomes are described.

  3. Validity of ankylosing spondylitis and undifferentiated spondyloarthritis diagnoses in the Swedish National Patient Register

    DEFF Research Database (Denmark)

    Lindström, U; Exarchou, S; Sigurdardottir, V

    2015-01-01

    (AS) and undifferentiated SpA (uSpA) in the NPR against the established classification criteria [modified New York (mNY), Assessment of SpondyloArthritis international Society (ASAS), Amor, and European Spondyloarthropathy Study Group (ESSG) criteria]. METHOD: All patients with an ICD-8/9/10 code...... for AS or uSpA had high PPVs, suggesting that our case identification in the Swedish NPR can be used for nationwide, population-based, epidemiological studies of these diseases....

  4. Undifferentiated-type gastric adenocarcinoma: prognostic impact of three histological types

    Directory of Open Access Journals (Sweden)

    Lee Han

    2012-11-01

    Full Text Available Abstract Background The prognostic value of the three constituents of undifferentiated-type gastric adenocarcinoma remains unclear. The present study assessed the clinicopathological characteristics and prognosis of undifferentiated-type mucinous adenocarcinoma (uMAC and signet ring cell carcinoma (SRC compared with those of poorly differentiated adenocarcinoma (PDAC. Methods In total, 1,376 patients with undifferentiated-type gastric adenocarcinoma were included, consisting of 1,002 patients diagnosed with PDAC, 54 with uMAC and 320 with SRC. Clinicopathological factors and survival rates were compared among the three histological types. Results Significant differences in the distribution of pathological stages were observed among the groups. Patients with SRC had a significantly better survival rate than those with PDAC or uMAC, in both the all patients including non-curative resected patients and curative-resected groups. In addition, there was significant difference in survival between the PDAC and uMAC groups. Multivariate analysis suggested that age, gender, tumor depth, lymph node metastasis and curability significantly affected survival. Histological type was not an independent prognostic factor. There was no significant difference in the pattern of recurrence among the three groups. Conclusions The uMAC and SRC had worse and favorable prognosis compared with PDCA, respectively. However, there were no differences in survival by pathological stage, thus histological type was not an independent predictor of prognosis.

  5. Expression of Neural Markers by Undifferentiated Mesenchymal-Like Stem Cells from Different Sources

    Directory of Open Access Journals (Sweden)

    Dana Foudah

    2014-01-01

    Full Text Available The spontaneous expression of neural markers, already demonstrated in bone marrow (BM mesenchymal stem cells (MSCs, has been considered as evidence of the MSCs’ predisposition to differentiate toward neural lineages, supporting their use in stem cell-based therapy for neural repair. In this study we have evaluated, by immunocytochemistry, immunoblotting, and flow cytometry experiments, the expression of neural markers in undifferentiated MSCs from different sources: human adipose stem cells (hASCs, human skin-derived mesenchymal stem cells (hS-MSCs, human periodontal ligament stem cells (hPDLSCs, and human dental pulp stem cells (hDPSCs. Our results demonstrate that the neuronal markers βIII-tubulin and NeuN, unlike other evaluated markers, are spontaneously expressed by a very high percentage of undifferentiated hASCs, hS-MSCs, hPDLSCs, and hDPSCs. Conversely, the neural progenitor marker nestin is expressed only by a high percentage of undifferentiated hPDLSCs and hDPSCs. Our results suggest that the expression of βIII-tubulin and NeuN could be a common feature of stem cells and not exclusive to neuronal cells. This could result in a reassessment of the use of βIII-tubulin and NeuN as the only evidence proving neuronal differentiation. Further studies will be necessary to elucidate the relevance of the spontaneous expression of these markers in stem cells.

  6. Thermal Inertia of Rocks and Rock Populations

    Science.gov (United States)

    Golombek, M. P.; Jakosky, B. M.; Mellon, M. T.

    2001-01-01

    The effective thermal inertia of rock populations on Mars and Earth is derived from a model of effective inertia versus rock diameter. Results allow a parameterization of the effective rock inertia versus rock abundance and bulk and fine component inertia. Additional information is contained in the original extended abstract.

  7. Tertiary stratigraphy and petroleum potential of cold bay-false pass area, Alaska Peninsula

    Energy Technology Data Exchange (ETDEWEB)

    McLean, H.

    1979-09-01

    Recent mapping clarifies the age, distribution, and environments of deposition of Tertiary sedimentary rocks along the outer part of the Alaska Peninsula and on Unimak Island. Marine and leaf-fossil assemblages indicate that the Belkofski Formation is of Oligocene age, and comprises interfingering marine and nonmarine volcaniclastic rocks. The Bear Lake Formation of Miocene age is not present in the Cold Bay area as previously mapped; and in a previously unmapped area, the Tachilni Formation of late Miocene and early Pliocene age extends from Cold Bay to False Pass. Pre-Tetiary rocks do not crop out along the shoreline of Unimak Island. The petroleum potential of Tertiary and Mesozoic rocks in the Cold Bay area is minimized by sandstone with poor reservoir properties, absence of organic-rich source rocks, and weakly developed folds. 4 figures.

  8. Case of Six-Year Disease-Free Survival with Undifferentiated Carcinoma of the Pancreas

    Directory of Open Access Journals (Sweden)

    Hiroyuki Saito

    2016-08-01

    Full Text Available Undifferentiated carcinoma of the pancreas (UDC is rare and has a dismal prognosis. Here, we report a case of 6-year disease-free survival with a mixed type of UDC and UDC with osteoclast-like giant cells, with a high mitotic index as well as perineural, lymphatic, vessel, and diaphragmatic invasion. The patient underwent radical distal pancreatectomy and was subsequently treated with adjuvant chemotherapy using gemcitabine plus S-1 followed by maintenance chemotherapy with oral tegafur-uracil. The patient has been doing well with no evidence of recurrence for more than 6 years after surgery.

  9. Undifferentiated pleomorphic sarcoma: indolent, tail-like recurrence of a high-grade tumor

    Energy Technology Data Exchange (ETDEWEB)

    Alpert, Justin S. [Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY (United States); Boland, Patrick [Memorial Sloan Kettering Cancer Center, Division of Orthopaedic Surgery, Department of Surgery, New York, NY (United States); Weill Medical College of Cornell University, New York, NY (United States); Hameed, Meera [Memorial Sloan Kettering Cancer Center, Department of Pathology, New York, NY (United States); Panicek, David M. [Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY (United States); Weill Medical College of Cornell University, New York, NY (United States)

    2018-01-15

    Recurrence of a soft tissue sarcoma typically manifests as a round or oval mass at imaging, and recurrent high-grade soft tissue sarcomas generally enlarge relatively rapidly. We present a case of high-grade undifferentiated pleomorphic sarcoma in the calf of a 48-year-old male that recurred as a thin, curvilinear ''tail'' of enhancing tissue at magnetic resonance imaging (MRI), with extremely indolent growth over a 7-year period. The unusual imaging finding of a slowly enlarging ''tail'' should not be dismissed as postoperative changes, even for a high-grade soft tissue sarcoma. (orig.)

  10. The Cambrian-Ordovician rocks of Sonora, Mexico, and southern Arizona, southwestern margin of North America (Laurentia): chapter 35

    Science.gov (United States)

    Page, William R.; Harris, Alta C.; Repetski, John E.; Derby, James R.; Fritz, R.D.; Longacre, S.A.; Morgan, W.A.; Sternbach, C.A.

    2013-01-01

    Cambrian and Ordovician shelf, platform, and basin rocks are present in Sonora, Mexico, and southern Arizona and were deposited on the southwestern continental margin of North America (Laurentia). Cambrian and Ordovician rocks in Sonora, Mexico, are mostly exposed in scattered outcrops in the northern half of the state. Their discontinuous nature results from extensive Quaternary and Tertiary surficial cover, from Tertiary and Mesozoic granitic batholiths in western Sonora, and from widespread Tertiary volcanic deposits in the Sierra Madre Occidental in eastern Sonora. Cambrian and Ordovician shelf rocks were deposited as part of the the southern miogeocline on the southwestern continental margin of North America.

  11. CERN Rocks

    CERN Document Server

    2004-01-01

    The 15th CERN Hardronic Festival took place on 17 July on the terrace of Rest 3 (Prévessin). Over 1000 people, from CERN and other International Organizations, came to enjoy the warm summer night, and to watch the best of the World's High Energy music. Jazz, rock, pop, country, metal, blues, funk and punk blasted out from 9 bands from the CERN Musiclub and Jazz club, alternating on two stages in a non-stop show.  The night reached its hottest point when The Canettes Blues Band got everybody dancing to sixties R&B tunes (pictured). Meanwhile, the bars and food vans were working at full capacity, under the expert management of the CERN Softball club, who were at the same time running a Softball tournament in the adjacent "Higgs Field". The Hardronic Festival is the main yearly CERN music event, and it is organized with the support of the Staff Association and the CERN Administration.

  12. A monoclonal antibody recognizes undifferentiation-specific carbohydrate moieties expressed on cell surface of the human dental pulp cells.

    Science.gov (United States)

    Kang, Kyung-Jung; Ko, Seon-Yle; Ryu, Chun-Jeih; Jang, Young-Joo

    2017-05-01

    Human dental pulp cells are obtained from dental pulp tissue, and have the ability to form dentin and a pulp-like complex. Although adult stem cells have been identified from the primary culture by using specific cell surface markers, the identity of surface markers for the purification of stem cells within the dental pulp population are still unclear. Previously, we had constructed monoclonal antibodies against the undifferentiated cell-specific surface markers of human dental pulp cells (hDPCs) by performing decoy immunization. Among them, a monoclonal antibody against the cell surface antigen of the undifferentiated hDPCs (named UPSA-1) was purified and its heavy and light chain consensus regions were analyzed. The cell surface binding affinity of UPSA-1 mAb on the undifferentiated hDPCs was stronger than that on the differentiated cells. When tunicamycin was applied to hDPSCs during culture, the cell surface binding affinity of the antibody was dramatically decreased, and dentinogenic differentiation was reduced. The purified UPSA-1 antigen band resulting from immunoprecipitation disappeared or shifted down on the SDS-PAGE by deglycosylation. These data suggested that glycosylation on the cell surface might be a marker of an undifferentiated state, and that UPSA-1 mAb might be useful for identifying the carbohydrate moiety on the cell surface of undifferentiated pulp cells. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  13. Study on tertiary in-situ leachable uranium mineralization conditions in South Songliao basin

    International Nuclear Information System (INIS)

    Zhang Zhenqiang; Li Guokuan; Zhao Zonghua; Zhang Jingxun

    2001-01-01

    Tertiary in-situ leachable mineralization in Songliao Basin was analyzed in theory in the past. Since 1998, regional investigation at 1:200000 scale has been done with about 120 holes drilled. Based on drill holes recording, section compiling and sample analysis, the authors investigate into the Tertiary in-situ leachable conditions including rock character, sedimentary facies, rock chemistry, organic substances, uranium content, sandstone porosity, sandstone bodies, interlayer oxidation, and hydro-dynamic value. The study would play important role in prospecting for in-situ leachable uranium in South Songliao basin

  14. Intensive combined modality therapy of small round cell and undifferentiated sarcomas in children and young adults

    International Nuclear Information System (INIS)

    Bader, J.L.; Dewan, R.; Watkins, E.; Kinsella, T.J.; Glatstein, E.; STeinberg, S.M.

    1989-01-01

    Seventy-five patients (ages 4-35 years) with the following small round cell tumors and undifferentiated sarcoma were treated at the National Cancer Institute: Ewing's sarcome (n=32), peripheral neuroepithelioma (n=14), rhabdomyosarcoma (n=24), undifferentiated sarcoma (n=5). Most patients had poor prognostic features including 36 (48%) with metastatic disease, and 42 (56%) with central (truncal) tumors (22 in the pelvis). Treatment included 5 cycles of intensive induction chemotherapy with vincristine, cyclophosphamide and adriamycin, plus aggressive local radiation therapy using simulation and computerized treatment planning for all patients. Thereafter, complete clinical responses were consolidated with intensive chemotherapy, total body irradiation and autologous bone marrow transplantation. There were three local only failures, 10 local plus distant failures, 36 distant only failures, 3 treatment-related deaths, and one intercurrent death. Overall actuarial survival and event-free survival at 4 years are 49 and 29%, respectively. Actuarial freedom from local progression was seen in 74% of patients at 4 years, quite remarkable considering the bulk and location of most of these tumors. Without aggressive surgery, many of these high risk patients had satisfactory outcomes, but better systemic treatments are still needed.(author). 44 refs.; 8 figs.; 6 tabs

  15. PDGFRa amplification in multiple skin lesions of undifferentiated pleomorphic sarcoma: A clue for intimal sarcoma metastases.

    Science.gov (United States)

    Osio, Amélie; Vignon-Pennamen, Marie-Dominique; Pedeutour, Florence; Le Maignan, Christine; Koskas, Fabien; Lebbé, Célèste; Janin, Anne; Battistella, Maxime

    2017-05-01

    A 62-year-old human immunodeficiency virus-positive man was admitted for multiple cutaneous and subcutaneous nodules on his lower limbs, corresponding to an undifferentiated proliferation of spindle and pleomorphic cells, with irregular nuclei and numerous mitoses. The tumor cells were negative for a large panel of immunohistochemical markers, except CD10. MDM2 immunohistochemical staining was also negative, leading to the diagnosis of Fédération Nationale des Centres de Lutte contre le Cancer grade III undifferentiated pleomorphic sarcoma (UPS). Array-comparative genomic hybridization showed a highly complex karyotype, with amplification of the 4q12 region, an area that contains only the platelet-derived growth factor receptor α (PDGFRa) gene. This amplification of PDFGRa, molecular hallmark of intimal sarcoma (IS), led to the diagnosis of skin IS metastasis. A positron emission tomography showed a hypermetabolic mass protruding in the preaortic area, consistent with the diagnosis of aortic IS. Our study shows that a rare differential diagnosis in peripheral UPS can be IS skin metastasis, and underlines the importance of molecular analyses in UPS. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  16. Prevalence of undifferentiated fever in adults of Rawalpindi having primary dengue fever.

    Science.gov (United States)

    Zafar, Humaira; Hayyat, Abbas; Akhtar, Naeem; Rizwan, Syeda Fatima

    2013-06-01

    The objectives of the study were to highlight early subclinical presentation of dengue viral infection (DVI) as an undifferentiated febrile illness. The descriptive cross-sectional study was carried out at Microbiology Department, Rawalpindi Medical College from March to September 2009. Stratified random sampling was used to select subjects from various urban and rural areas of Rawalpindi, and Serum IgG anti-dengue antibodies were detected by using 3rd generation enzyme-linked immunosorbent assay (ELISA). Out of the total 240 subjects, 69 (28.75%) were found to be positive for anti-dengue IgG antibodies. Of the positive cases, 41 (59.4%) - comprising 31 (44.9%) urban residents - and 10 (14.4%) rural residents presented with a previous history of undifferentiated fever (p<0.05). It was concluded that primary DVI can present as subclinical form in healthy population residing in rural and urban areas of Rawalpindi, which is an alarming situation indicating the spread of disease in the study area.

  17. Prevalence of undifferentiated fever in adults of Rawalpindi having primary dengue fever

    International Nuclear Information System (INIS)

    Zafar, H.; Hayyat, A.; Akhtar, N.

    2013-01-01

    The objectives of the study were to highlight early subclinical presentation of dengue viral infection (DVI) as an undifferentiated febrile illness. The descriptive cross-sectional study was carried out at Microbiology Department, Rawalpindi Medical College from March to September 2009. Stratified random sampling was used to select subjects from various urban and rural areas of Rawalpindi, and Serum IgG anti-dengue antibodies were detected by using 3rd generation enzyme-linked immunosorbent assay (ELISA). Out of the total 240 subjects, 69 (28.75%) were found to be positive for anti-dengue IgG antibodies. Of the positive cases, 41 (59.4%) - comprising 31 (44.9%) urban residents - and 10 (14.4%) rural residents presented with a previous history of undifferentiated fever (p<0.05). It was concluded that primary DVI can present as subclinical form in healthy population residing in rural and urban areas of Rawalpindi, which is an alarming situation indicating the spread of disease in the study area. (author)

  18. High Iridium concentration of alkaline rocks of Deccan and ...

    Indian Academy of Sciences (India)

    R. Narasimhan, Krishtel eMaging Solutions

    We report here an unusually high concentration of iridium in some alkali basalts and alkaline rocks of Deccan region having an age of about 65Ma, similar to the age of the Cretaceous-Tertiary boundary. The alkali basalts of Anjar, in the western periphery of Deccan province, have irid- ium concentration as high as 178pg/g ...

  19. Rollerjaw Rock Crusher

    Science.gov (United States)

    Peters, Gregory; Brown, Kyle; Fuerstenau, Stephen

    2009-01-01

    The rollerjaw rock crusher melds the concepts of jaw crushing and roll crushing long employed in the mining and rock-crushing industries. Rollerjaw rock crushers have been proposed for inclusion in geological exploration missions on Mars, where they would be used to pulverize rock samples into powders in the tens of micrometer particle size range required for analysis by scientific instruments.

  20. Sustained levels of FGF2 maintain undifferentiated stem cell cultures with biweekly feeding.

    Directory of Open Access Journals (Sweden)

    Steven Lotz

    Full Text Available An essential aspect of stem cell culture is the successful maintenance of the undifferentiated state. Many types of stem cells are FGF2 dependent, and pluripotent stem cells are maintained by replacing FGF2-containing media daily, while tissue-specific stem cells are typically fed every 3rd day. Frequent feeding, however, results in significant variation in growth factor levels due to FGF2 instability, which limits effective maintenance due to spontaneous differentiation. We report that stabilization of FGF2 levels using controlled release PLGA microspheres improves expression of stem cell markers, increases stem cell numbers and decreases spontaneous differentiation. The controlled release FGF2 additive reduces the frequency of media changes needed to maintain stem cell cultures, so that human embryonic stem cells and induced pluripotent stem cells can be maintained successfully with biweekly feedings.

  1. Can Villin be Used to Identify Malignant and Undifferentiated Normal Digestive Epithelial Cells?

    Science.gov (United States)

    Robine, S.; Huet, C.; Moll, R.; Sahuquillo-Merino, C.; Coudrier, E.; Zweibaum, A.; Louvard, D.

    1985-12-01

    We have investigated the presence of villin (a Ca2+-regulated actin binding protein) in various tissues (normal or malignant) and in established cell lines by using sensitive immunochemical techniques on cell extracts and immunofluorescence analysis on frozen sections. Our results show that villin is a marker that can be used to distinguish normal differentiated epithelial cells from the simple epithelia lining the gastrointestinal tract and renal tubules. Villin is found in the absorptive cells of the small and large intestines, in the duct cells of pancreas and biliary system, and in the cells of kidney proximal tubules. Furthermore, undifferentiated normal and tumoral cells of intestinal origin in vivo and in cell culture express villin. Therefore, expression of villin is seen in cells that do not necessarily display the morphological features characteristic of their terminally differentiated state, such as the microvilli-lined brush border. We suggest the possible clinical implications of using villin as a marker in the diagnosis of metastatic adenocarcinomas.

  2. Recurrent ovarian undifferentiated carcinoma resembling hepatoid morphology treated with pegylated liposomal doxorubicin and bevacizumab.

    Science.gov (United States)

    Ishiguro, Tatsuya; Kashima, Kastunori; Yachida, Nozomi; Motoyama, Teiichi; Enomoto, Takayuki

    2017-05-01

    Hepatoid carcinomas are undifferentiated epithelial carcinomas that are pathologically similar to hepatocellular carcinoma, but occur in a variety of organs. Hepatoid carcinomas, as strictly defined, typically produce α-fetoprotein. In addition, a standard effective chemotherapy regimen for hepatoid carcinoma has yet to be established. We present a case of advanced primary ovarian cancer that was pathologically similar to hepatoid carcinoma without staining for α-fetoprotein or hepatocyte paraffin 1. The primary ovarian, metastatic, and recurrent tumors shared similar pathological characteristics. Fourth-line chemotherapy with pegylated liposomal doxorubicin and bevacizumab was effective in treating the recurrent tumor, even though this disease had recurred three times. © 2017 Japan Society of Obstetrics and Gynecology.

  3. Undifferentiated embryonic cell transcription factor 1 regulates ESC chromatin organization and gene expression

    DEFF Research Database (Denmark)

    Kooistra, Susanne M; van den Boom, Vincent; Thummer, Rajkumar P

    2010-01-01

    Previous reports showed that embryonic stem (ES) cells contain hyperdynamic and globally transcribed chromatin-properties that are important for ES cell pluripotency and differentiation. Here, we demonstrate a role for undifferentiated embryonic cell transcription factor 1 (UTF1) in regulating ES...... cell chromatin structure. Using chromatin immunoprecipitation-on-chip analysis, we identified >1,700 UTF1 target genes that significantly overlap with previously identified Nanog, Oct4, Klf-4, c-Myc, and Rex1 targets. Gene expression profiling showed that UTF1 knock down results in increased expression...... of a large set of genes, including a significant number of UTF1 targets. UTF1 knock down (KD) ES cells are, irrespective of the increased expression of several self-renewal genes, Leukemia inhibitory factor (LIF) dependent. However, UTF1 KD ES cells are perturbed in their differentiation in response...

  4. New strategies for the treatment of undifferentiated thyroid cancer and poorly differentiated thyroid cancer

    International Nuclear Information System (INIS)

    Juvenal, Guillermo J.

    2006-01-01

    Undifferentiated thyroid cancer, which accounts for about 5-10% of thyroid cancer cases, is a very aggressive tumor with no effective treatment, since it lacks iodine uptake and does not respond to radio or chemotherapy. The prognosis of these patients is bad, due to the rapid growth of the tumor and the early development of metastasis. Oncogenes and tumor suppressor genes are involved in the genetic changes that underlie thyroid cancer, as all kinds of tumors. The characterization of these proteins is being exploited to delineate new therapeutic strategies for the treatment of this cancer. This work is focused on those compounds or therapeutic approaches that are being used in clinical essays or in animal models. (author) [es

  5. Undifferentiated and differentiated PC12 cells protected by huprines against injury induced by hydrogen peroxide.

    Directory of Open Access Journals (Sweden)

    Marta Pera

    Full Text Available Oxidative stress is implicated in the pathogenesis of neurodegenerative disorders and hydrogen peroxide (H2O2 plays a central role in the stress. Huprines, a group of potent acetylcholinesterase inhibitors (AChEIs, have shown a broad cholinergic pharmacological profile. Recently, it has been observed that huprine X (HX improves cognition in non transgenic middle aged mice and shows a neuroprotective activity (increased synaptophysin expression in 3xTg-AD mice. Consequently, in the present experiments the potential neuroprotective effect of huprines (HX, HY, HZ has been analyzed in two different in vitro conditions: undifferentiated and NGF-differentiated PC12 cells. Cells were subjected to oxidative insult (H2O2, 200 µM and the protective effects of HX, HY and HZ (0.01 µM-1 µM were analyzed after a pre-incubation period of 24 and 48 hours. All huprines showed protective effects in both undifferentiated and NGF-differentiated cells, however only in differentiated cells the effect was dependent on cholinergic receptors as atropine (muscarinic antagonist, 0.1 µM and mecamylamine (nicotinic antagonist, 100 µM reverted the neuroprotection action of huprines. The decrease in SOD activity observed after oxidative insult was overcome in the presence of huprines and this effect was not mediated by muscarinic or nicotinic receptors. In conclusion, huprines displayed neuroprotective properties as previously observed in in vivo studies. In addition, these effects were mediated by cholinergic receptors only in differentiated cells. However, a non-cholinergic mechanism, probably through an increase in SOD activity, seems to be also involved in the neuroprotective effects of huprines.

  6. Undifferentiated and Differentiated PC12 Cells Protected by Huprines Against Injury Induced by Hydrogen Peroxide

    Science.gov (United States)

    Pera, Marta; Camps, Pelayo; Muñoz-Torrero, Diego; Perez, Belen; Badia, Albert; Clos Guillen, M Victoria

    2013-01-01

    Oxidative stress is implicated in the pathogenesis of neurodegenerative disorders and hydrogen peroxide (H2O2) plays a central role in the stress. Huprines, a group of potent acetylcholinesterase inhibitors (AChEIs), have shown a broad cholinergic pharmacological profile. Recently, it has been observed that huprine X (HX) improves cognition in non transgenic middle aged mice and shows a neuroprotective activity (increased synaptophysin expression) in 3xTg-AD mice. Consequently, in the present experiments the potential neuroprotective effect of huprines (HX, HY, HZ) has been analyzed in two different in vitro conditions: undifferentiated and NGF-differentiated PC12 cells. Cells were subjected to oxidative insult (H2O2, 200 µM) and the protective effects of HX, HY and HZ (0.01 µM–1 µM) were analyzed after a pre-incubation period of 24 and 48 hours. All huprines showed protective effects in both undifferentiated and NGF-differentiated cells, however only in differentiated cells the effect was dependent on cholinergic receptors as atropine (muscarinic antagonist, 0.1 µM) and mecamylamine (nicotinic antagonist, 100 µM) reverted the neuroprotection action of huprines. The decrease in SOD activity observed after oxidative insult was overcome in the presence of huprines and this effect was not mediated by muscarinic or nicotinic receptors. In conclusion, huprines displayed neuroprotective properties as previously observed in in vivo studies. In addition, these effects were mediated by cholinergic receptors only in differentiated cells. However, a non-cholinergic mechanism, probably through an increase in SOD activity, seems to be also involved in the neuroprotective effects of huprines. PMID:24086337

  7. ESR dating of the fault rocks

    International Nuclear Information System (INIS)

    Lee, Hee Kwon

    2005-01-01

    We carried out ESR dating of fault rocks collected near the nuclear reactor. The Upcheon fault zone is exposed close to the Ulzin nuclear reactor. The space-time pattern of fault activity on the Upcheon fault deduced from ESR dating of fault gouge can be summarised as follows : this fault zone was reactivated between fault breccia derived from Cretaceous sandstone and tertiary volcanic sedimentary rocks about 2 Ma, 1.5 Ma and 1 Ma ago. After those movements, the Upcheon fault was reactivated between Cretaceous sandstone and fault breccia zone about 800 ka ago. This fault zone was reactivated again between fault breccia derived form Cretaceous sandstone and Tertiary volcanic sedimentary rocks about 650 ka and after 125 ka ago. These data suggest that the long-term(200-500 k.y.) cyclic fault activity of the Upcheon fault zone continued into the Pleistocene. In the Ulzin area, ESR dates from the NW and EW trend faults range from 800 ka to 600 ka NE and EW trend faults were reactivated about between 200 ka and 300 ka ago. On the other hand, ESR date of the NS trend fault is about 400 ka and 50 ka. Results of this research suggest the fault activity near the Ulzin nuclear reactor fault activity continued into the Pleistocene. One ESR date near the Youngkwang nuclear reactor is 200 ka

  8. A Comparison of Androgynous, Feminine, Masculine, and Undifferentiated Women on Self-Esteem, Body Satisfaction, and Sexual Satisfaction.

    Science.gov (United States)

    Kimlicka, Thomas; And Others

    1983-01-01

    Compared sex-role orientations of female undergraduates (N=204) who completed the Bem Sex Role Inventory. Androgyny and masculinity were associated with self-esteem, body satisfaction, and sexual satisfaction. Androgynous and masculine subjects were generally similar and well adjusted; feminine and undifferentiated subjects were similar and less…

  9. Diagnostic and predictive value of acute-phase reactants in adult undifferentiated peripheral inflammatory arthritis: a systematic review

    NARCIS (Netherlands)

    Vercoutere, Ward; Thevissen, Kristof; Bombardier, Claire; Landewé, Robert B. M.

    2011-01-01

    To review the available literature on the diagnostic and predictive value of acute-phase reactants in adult undifferentiated peripheral inflammatory arthritis (UPIA) as an evidence base for generating multinational clinical practice recommendations in the 3e Initiative in Rheumatology. A systematic

  10. Inhibition by pectic oligosaccharides of the invasion of undifferentiated and differentiated Caco-2 cells by Campylobacter jejuni

    Science.gov (United States)

    The ability of pectic oligosaccharides (POS) to inhibit adherence to and invasion of undifferentiated (UC) and differentiated (DC) Caco-2 cells by Campylobacter jejuni (C. jejuni) was investigated. It was observed that both adherence and invasion were significantly higher in UC than in DC. POS (2.5 ...

  11. Indistinguishable genomic profiles and shared prognostic markers in undifferentiated pleomorphic sarcoma and leiomyosarcoma: different sides of a single coin?

    DEFF Research Database (Denmark)

    Carneiro, Ana; Francis, Princy; Bendahl, Pär-Ola

    2009-01-01

    Soft tissue sarcoma (STS) diagnostics and prognostics are challenging, particularly in highly malignant and pleomorphic subtypes such as undifferentiated pleomorphic sarcoma (UPS) and leiomyosarcoma (LMS). We applied 32K BAC arrays and gene expression profiling to 18 extremity soft tissue LMS...

  12. Etiologies of acute undifferentiated fever and clinical prediction of scrub typhus in a non-tropical endemic area.

    Science.gov (United States)

    Jung, Ho-Chul; Chon, Sung-Bin; Oh, Won Sup; Lee, Dong-Hyun; Lee, Ho-Jin

    2015-02-01

    Scrub typhus usually presents as acute undifferentiated fever. This cross-sectional study included adult patients presenting with acute undifferentiated fever defined as any febrile illness for ≤ 14 days without evidence of localized infection. Scrub typhus cases were defined by an antibody titer of a ≥ fourfold increase in paired sera, a ≥ 1:160 in a single serum using indirect immunofluorescence assay, or a positive result of the immunochromatographic test. Multiple regression analysis identified predictors associated with scrub typhus to develop a prediction rule. Of 250 cases with known etiology of acute undifferentiated fever, influenza (28.0%), hepatitis A (25.2%), and scrub typhus (16.4%) were major causes. A prediction rule for identifying suspected cases of scrub typhus consisted of age ≥ 65 years (two points), recent fieldwork/outdoor activities (one point), onset of illness during an outbreak period (two points), myalgia (one point), and eschar (two points). The c statistic was 0.977 (95% confidence interval = 0.960-0.994). At a cutoff value ≥ 4, the sensitivity and specificity were 92.7% (79.0-98.1%) and 90.9% (86.0-94.3%), respectively. Scrub typhus, the third leading cause of acute undifferentiated fever in our region, can be identified early using the prediction rule. © The American Society of Tropical Medicine and Hygiene.

  13. Geologic framework of nonmarine cretaceous-tertiary boundary sites, raton basin, new mexico and colorado

    Science.gov (United States)

    Pillmore, C.L.; Tschudy, R.H.; Orth, C.J.; Gilmore, J.S.; Knight, J.D.

    1984-01-01

    Indium concentrations are anomalously high at the palynological Cretaceous-Tertiary boundary in fluvial sedimentary rocks of the lower part of the Raton Formation at several localities in the Raton Basin of New Mexico and Colorado. The iridium anomaly is associated with a thin bed of kaolinitic claystone in a discontinuous carbonaceous shale and coal sequence.

  14. Rocks Can Wow? Yes, Rocks Can Wow!

    Science.gov (United States)

    Hardman, Sally; Luke, Sue

    2016-01-01

    Rocks and fossils appear in the National Curriculum of England science programmes of study for children in year 3 (ages 7-8). A frequently asked question is "How do you make the classification of rocks engaging?" In response to this request from a school, a set of interactive activities was designed and organised by tutors and students…

  15. Rock Slope Design Criteria

    Science.gov (United States)

    2010-06-01

    Based on the stratigraphy and the type of slope stability problems, the flat lying, Paleozoic age, sedimentary : rocks of Ohio were divided into three design units: 1) competent rock design unit consisting of sandstones, limestones, : and siltstones ...

  16. Rocks in Our Pockets

    Science.gov (United States)

    Plummer, Donna; Kuhlman, Wilma

    2005-01-01

    To introduce students to rocks and their characteristics, teacher can begin rock units with the activities described in this article. Students need the ability to make simple observations using their senses and simple tools.

  17. Rock slope design guide.

    Science.gov (United States)

    2011-04-01

    This Manual is intended to provide guidance for the design of rock cut slopes, rockfall catchment, and : rockfall controls. Recommendations presented in this manual are based on research presented in Shakoor : and Admassu (2010) entitled Rock Slop...

  18. Acute undifferentiated fever in India: a multicentre study of aetiology and diagnostic accuracy.

    Science.gov (United States)

    Mørch, Kristine; Manoharan, Anand; Chandy, Sara; Chacko, Novin; Alvarez-Uria, Gerardo; Patil, Suvarna; Henry, Anil; Nesaraj, Joel; Kuriakose, Cijoy; Singh, Ashita; Kurian, Siby; Gill Haanshuus, Christel; Langeland, Nina; Blomberg, Bjørn; Vasanthan Antony, George; Mathai, Dilip

    2017-10-04

    The objectives of this study were to determine the proportion of malaria, bacteraemia, scrub typhus, leptospirosis, chikungunya and dengue among hospitalized patients with acute undifferentiated fever in India, and to describe the performance of standard diagnostic methods. During April 2011-November 2012, 1564 patients aged ≥5 years with febrile illness for 2-14 days were consecutively included in an observational study at seven community hospitals in six states in India. Malaria microscopy, blood culture, Dengue rapid NS1 antigen and IgM Combo test, Leptospira IgM ELISA, Scrub typhus IgM ELISA and Chikungunya IgM ELISA were routinely performed at the hospitals. Second line testing, Dengue IgM capture ELISA (MAC-ELISA), Scrub typhus immunofluorescence (IFA), Leptospira Microscopic Agglutination Test (MAT), malaria PCR and malaria immunochromatographic rapid diagnostic test (RDT) Parahit Total™ were performed at the coordinating centre. Convalescence samples were not available. Case definitions were as follows: Leptospirosis: Positive ELISA and positive MAT. Scrub typhus: Positive ELISA and positive IFA. Dengue: Positive RDT and/or positive MAC-ELISA. Chikungunya: Positive ELISA. Bacteraemia: Growth in blood culture excluding those defined as contaminants. Malaria: Positive genus-specific PCR. Malaria was diagnosed in 17% (268/1564) and among these 54% had P. falciparum. Dengue was diagnosed in 16% (244/1564). Bacteraemia was found in 8% (124/1564), and among these Salmonella typhi or S. paratyphi constituted 35%. Scrub typhus was diagnosed in 10%, leptospirosis in 7% and chikungunya in 6%. Fulfilling more than one case definition was common, most frequent in chikungunya where 26% (25/98) also had positive dengue test. Malaria and dengue were the most common causes of fever in this study. A high overlap between case definitions probably reflects high prevalence of prior infections, cross reactivity and subclinical infections, rather than high prevalence of

  19. Longitudinal analysis of quality of life in patients with undifferentiated connective tissue diseases

    Directory of Open Access Journals (Sweden)

    Iudici M

    2017-02-01

    Full Text Available Michele Iudici, Rosaria Irace, Antonella Riccardi, Giovanna Cuomo, Serena Vettori, Gabriele Valentini Rheumatology Section, Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy Introduction/objectives: To prospectively assess the quality of life (QoL of patients affected by undifferentiated connective tissue diseases (UCTDs and to identify factors associated with changes over time.Patients and methods: A total of 46 consecutive UCTD patients completed the Short-Form 36 (SF-36 questionnaire at presentation and then yearly. At each 6-month visit, all patients underwent a detailed history taking and a laboratory and physical assessment, in order to follow the evolution of the disease over time and to assess the the co-existence of fibromyalgia.Results: At presentation, scores lower than the average of the general population were detected in 34 (74% and 41 (89% patients in the physical and mental domains, respectively. No difference between patients with and without Raynaud’s phenomenon was detected. Fibromyalgia was the only independent variable associated with an impaired physical component summary score (p = 0.0009. No patient feature was found to be associated with the basal mental component summary score. During 24 months of follow-up, a significant improvement (ie, a change ≥5 from baseline in physical component summary and mental component summary scores was observed in 14 (33.3% and 20 (43.4% patients, respectively. Patients who significantly improved in the physical domain more frequently had a history of glucocorticoids intake (p < 0.001, while those who improved in the mental component more frequently had a history of either glucocorticoids (p = 0.043 or immunosuppressors (p = 0.037 intake during follow-up.Conclusion: UCTD patients perceive a worse QoL, regardless of Raynaud’s phenomenon Fibromyalgia is one of the major contributors of physical QoL, whereas no factor influencing

  20. Promoted neuronal differentiation after activation of alpha4/beta2 nicotinic acetylcholine receptors in undifferentiated neural progenitors.

    Directory of Open Access Journals (Sweden)

    Takeshi Takarada

    Full Text Available BACKGROUND: Neural progenitor is a generic term used for undifferentiated cell populations of neural stem, neuronal progenitor and glial progenitor cells with abilities for proliferation and differentiation. We have shown functional expression of ionotropic N-methyl-D-aspartate (NMDA and gamma-aminobutyrate type-A receptors endowed to positively and negatively regulate subsequent neuronal differentiation in undifferentiated neural progenitors, respectively. In this study, we attempted to evaluate the possible functional expression of nicotinic acetylcholine receptor (nAChR by undifferentiated neural progenitors prepared from neocortex of embryonic rodent brains. METHODOLOGY/PRINCIPAL FINDINGS: Reverse transcription polymerase chain reaction analysis revealed mRNA expression of particular nAChR subunits in undifferentiated rat and mouse progenitors prepared before and after the culture with epidermal growth factor under floating conditions. Sustained exposure to nicotine significantly inhibited the formation of neurospheres composed of clustered proliferating cells and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide reduction activity at a concentration range of 1 µM to 1 mM without affecting cell survival. In these rodent progenitors previously exposed to nicotine, marked promotion was invariably seen for subsequent differentiation into cells immunoreactive for a neuronal marker protein following the culture of dispersed cells under adherent conditions. Both effects of nicotine were significantly prevented by the heteromeric α4β2 nAChR subtype antagonists dihydro-β-erythroidine and 4-(5-ethoxy-3-pyridinyl-N-methyl-(3E-3-buten-1-amine, but not by the homomeric α7 nAChR subtype antagonist methyllycaconitine, in murine progenitors. Sustained exposure to nicotine preferentially increased the expression of Math1 among different basic helix-loop-helix proneural genes examined. In undifferentiated progenitors from embryonic mice

  1. Tertiary climatic fluctuations and methods of analysis of tertiary floras

    Science.gov (United States)

    Wolfe, J.A.

    1971-01-01

    On theoretical grounds, an analysis of the physiognomy of a Tertiary leaf assemblage is more direct and reliable than a circuitous floristic analysis in assigning thermal regimes to fossil assemblages. Using primarily foliar physiognomy and secondarily floristic composition, it can be shown that: (1) some middle latitude Tertiary assemblages probably lived under meteoroligically tropical climates; (2) a major and rapid climatic deterioration occurred in the Oligocene; and (3) a major climatic fluctuation probably occurred in the Late Eocene. These analyses thus substantiate the conclusions of several other paleobotanists regarding climatic fluctuations. Recent criticisms of these analyses are shown to be invalid and to be based largely on misinterpretations. ?? 1971.

  2. Evaluation of florfenicol for the treatment of undifferentiated fever in feedlot calves in western Canada.

    Science.gov (United States)

    Booker, C W; Jim, G K; Guichon, P T; Schunicht, O C; Thorlakson, B E; Lockwood, P W

    1997-01-01

    A study was conducted in western Canada to evaluate the efficacy of florfenicol for the treatment of undifferentiated fever (UF) in feedlot calves. One hundred and twenty-five recently weaned, auction market derived, crossbred, beef steer calves suffering from UF were allocated to 1 of 2 experimental groups as follows: florfenicol, which was intramuscular florfenicol administered at the rate of 20 mg/kg body weight at the time of allocation (day 0) and again 48 h later; or control, which was intramuscular saline administered at the same volume as florfenicol at the time of allocation and again 48 h later. Eighty-four calves were allocated to the florfenicol group and 41 calves were allocated to the control group. Outcome measures describing animal health, body weight, and rectal temperature parameters were used to determine the efficacy of florfenicol for the treatment of UF. The 1st relapse of UF, 2nd relapse of UF, overall mortality, bovine respiratory disease mortality, and haemophilosis mortality rates were significantly (P florfenicol group than in the control group. Animals in the florfenicol group were significantly (P florfenicol group was significantly (P florfenicol is an efficacious antimicrobial for the treatment of UF. PMID:9285135

  3. Histologic and Genetic Advances in Refining the Diagnosis of “Undifferentiated Pleomorphic Sarcoma”

    Directory of Open Access Journals (Sweden)

    Antonella Viterbo

    2013-02-01

    Full Text Available Undifferentiated pleomorphic sarcoma (UPS is an inclusive term used for sarcomas that defy formal sub-classification. The frequency with which this diagnosis is assigned has decreased in the last twenty years. This is because when implemented, careful histologic assessment, immunohistochemistry, and ultra-structural evaluation can often determine lineage of differentiation. Further attrition in the diagnostic frequency of UPS may arise by using array-comparative genomic hybridization. Gene expression arrays are also of potential use as they permit hierarchical gene clustering. Appraisal of the literature is difficult due to a historical perspective in which specific molecular diagnostic methods were previously unavailable. The American Joint Committee on Cancer (AJCC classification has changed with different inclusion criteria. Taxonomy challenges also exist with the older term “malignant fibrous histiocytoma” being replaced by “UPS”. In 2010 an analysis of multiple sarcoma expression databases using a 170-gene predictor, re-classified most MFH and “not-otherwise-specified” (NOS tumors as liposarcomas, leiomyosarcomas or fibrosarcomas. Interestingly, some of the classifier genes are potential molecular therapeutic targets including Insulin-like growth factor 1 (IGF-1, Peroxisome proliferator-activated receptor γ (PPARγ, Nerve growth factor β (NGF β and Fibroblast growth factor receptor (FGFR.

  4. MR imaging of myxofibrosarcoma and undifferentiated sarcoma with emphasis on tail sign; diagnostic and prognostic value

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Hye Jin; Hong, Sung Hwan; Kang, Yusuhn; Choi, Ja-Young; Yi, Minkyong [Seoul National University College of Medicine, Seoul National University Hospital, Department of Radiology, Seoul (Korea, Republic of); Moon, Kyung Chul [Seoul National University College of Medicine, Seoul National University Hospital, Department of Pathology, Seoul (Korea, Republic of); Kim, Han-Soo; Han, Ilkyu [Seoul National University College of Medicine, Seoul National University Hospital, Department of Orthopedic Surgery, Seoul (Korea, Republic of); Kang, Heung Sik [Seoul National University Bundang Hospital, Department of Radiology, Seongnam-City, Gyeongi-Do (Korea, Republic of)

    2014-08-15

    To assess the prevalence of the tail sign in soft tissue sarcomas and determine whether the local recurrence rate differed based on the presence of the tail sign. In our retrospective study, myxofibrosarcoma (MFS, n = 25) and undifferentiated sarcoma (US, n = 38) comprised group 1, and the remaining tumours (n = 115) were assigned to group 2. Location, size, and imaging features of the tumours were assessed on MRI. The radiological-pathological correlation of the tail sign was analysed. The tail sign, thick fascial enhancement extending from the tumour margin, was more common and significantly thicker in group 1. In the subgroup analysis between MFS and US, there was no significant difference in the presence of a tail sign. Histological examination revealed extensive tumour cell infiltrations along the deep fascia from the main mass. Patients with a tail sign had a worse local recurrence-free survival than patients without it, not only in all tumours (p < 0.01), but also in group 1 (p = 0.019) The tail sign was a common MRI feature of both MFS and US, and was also associated with worse local recurrence-free survival. Radiologists should be aware of these MRI findings and inform the surgeon preoperatively in order to obtain a sufficient surgical margin to minimise the risk of local tumour recurrence. (orig.)

  5. Undifferentiated connective tissue disease presenting with prevalent interstitial lung disease: Case report and review of literature

    Directory of Open Access Journals (Sweden)

    Sfriso Paolo

    2011-06-01

    Full Text Available Abstract Undifferentiated connective tissue diseases (UCTDs are clinical entities characterised by signs and symptoms suggestive of a systemic autoimmune disease, which do not fulfil the diagnostic criteria for a defined connective tissue disease. Lung involvement can complicate the course and management of the disease, often determining a worse outcome. Respiratory dysfunction as the first clinical manifestation has seldom been reported. We describe a case of a female patient who developed significant respiratory dysfunction as the principal clinical sign. Video-assisted thoracoscopy was performed and a histological pattern of nonspecific interstitial pneumonia (NSIP was found. A pathological diagnosis suggested careful follow-up with extensive immunological screening which then detected Raynaud's phenomenon and positivity of antinuclear antibodies. After a multidisciplinary discussion (pneumologist, radiologist, pathologist and rheumatologist a final diagnosis of NSIP associated with UCTD was made. The diagnosis of UCTD should be considered when NSIP is diagnosed even in cases with evident first clinical manifestations of severe respiratory dysfunction. A multidisciplinary approach in the field of interstitial lung disease with NSIP, also including rheumatologic expertise, is fundamental to achieve a prompt and correct diagnosis.

  6. Risk factors for the occurrence of undifferentiated carcinoma of nasopharyngeal type: A case-control study

    Directory of Open Access Journals (Sweden)

    Nešić Vladimir

    2010-01-01

    Full Text Available Introduction. The incidence rate of nasopharyngeal carcinoma in Serbia is less than one per 100,000 citizens, which classifies it as a region with low incidence for this disease. Objective. The aim of this study was to test some hypotheses of the risk factors for undifferentiated carcinoma of nasopharyngeal type (UCNT in the low incidence population. Methods. A case-control study was used for the research. The study included 45 cases with histopathological diagnosis of UCNT and 90 controls. Cases and the controls were individually matched by sex, age (±3 years, and place of residence (city-village. Data were gathered about sociodemographic characteristics, occupational exposure to harmful agents, habits, diet, personal history, and family history. In the analysis of the data, conditional univariate and multivariate logistic regression analyses were applied. Results. According to the results of multivariate logistic regression analysis UCNT was significantly positively associated with 'passive smoking' of tobacco in the family during childhood, frequent consumption of industrially manufactured food additives for enhancing flavour and frequent consumption of white bread. UCNT was significantly negatively associated with frequent consumption of margarine, olive oil and cornbread. Conclusion. In our low incidence population, an independent risk factor for the occurrence of UCNT was 'passive smoking' of tobacco in the family during childhood, use of industrially manufactured food with additives for enhancing flavour and consumption of white bread. Multicentric study enrolling a greater number of cases would be desirable.

  7. Predict rheumatoid arthritis conversion from undifferentiated arthritis with dynamic contrast-enhanced MRI and laboratory indexes.

    Science.gov (United States)

    Lei, Xinwei; Li, Huixia; Zhan, Ying; Qu, Jin

    2018-01-15

    To investigate the clinical value of dynamic contrast-enhanced MRI (DCE-MRI) and laboratory indexes in predicting conversion from undifferentiated arthritis (UA) to rheumatoid arthritis (RA). A total 81 DMARD-naive UA patients were studied. 37 cases were ultimately diagnosed as RA, 32 cases were diagnosed as other types of arthritis, and the remaining cases were still UA during the 1-year follow-up. The DCE-MRI and laboratory measures were fed into a logistic regression analysis. Wash-in rate and anti-cyclic citrullinated peptide (anti-CCP) antibody served as the final variables into the regression equation (pCCP antibody positive achieved a sensitivity of 37.8% and specificity of 90.9%. The combination of wash-in rate and anti-CCP antibody positive improved specificity (100%) but not sensitivity (27.3%). The conversion from UA to RA is highly predictable. The wash-in rate of DCE-MRI can be used as an important biomarker to predict UA progression.

  8. Undifferentiated tropical febrile illness in Cordoba, Colombia: Not everything is dengue.

    Science.gov (United States)

    Mattar, Salim; Tique, Vaneza; Miranda, Jorge; Montes, Eney; Garzon, Denisses

    In Colombia, undifferentiated tropical febrile illness (UTFI) are frequent and of considerable concern. They also share many clinical features. Between 2012 and 2013 in an endemic tropical area of Cordoba, Colombia, we conducted a prospective study to establish an etiological diagnosis of UTFI. Using diagnostic tests for dengue, leptospirosis, hantavirus, malaria, rickettsia, brucellosis, hepatitis A and B on 100 patients recruited for the study. We identified 69 patients with presumed UTFI: leptospirosis (n=27), dengue (n=26), hantavirus infection (n=4), malaria (n=4), rickettsial infection (n=2), hepatitis A (n=1), and brucellosis (n=1); no hepatitis B cases were detected. Co-infections with malaria and leptospirosis (n=1), hepatitis A and dengue (n=1), hantavirus and dengue (n=1), hantavirus, dengue, and leptospirosis (n=1) were also identified. No etiologic agent was identified for 31 patients. We conclude that other etiologic agents besides dengue virus deserve greater attention by physicians and public health authorities in tropical area of Colombia. Copyright © 2016 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Ltd. All rights reserved.

  9. Squamous cell carcinoma and undifferentiated carcinoma of the inner nose and the paranasal sinuses

    International Nuclear Information System (INIS)

    Wustrow, J.; Rudert, H.; Diercks, M.; Beigel, A.

    1989-01-01

    272 patients with tumours of the nasal cavity and paranasal sinuses were followed up from 1949 until 1982. 53% of the tumours were classified as squamous cell or undifferentiated carcinomata. The most common site of squamous cell carcinoma is the maxillary sinus (50%). Distant metastases and regional lymph node metastases are rarely seen at presentation regardless of the size of the primary tumour. Metastases usually indicate a tumour dependent death in the near future. The main prognostic indicators are the size of the tumour (significantly worse prognosis for T4 in comparison to T2 or T3 tumours) and the localisation (significantly better prognosis for tumours of the floor of the nasal cavity or the nasal septum compared to tumours of the paranasal sinuses). The age of the patient or the degree of differentiation of the tumour did not influence on the survival rate. Tumour dependent deaths rarely occur after more than five years. Patients were assigned to two treatment groups and matched according to the tumour stage. One group received surgery only, whereas the second group received a combined treatment of surgery with subsequent radiotherapy. There was a significant difference between the two groups in favour of the surgical treatment. According to these data we recommend surgical excision without postoperative irradiation in cases where complete removal of the tumor has been histologically proven. (orig./MG) [de

  10. Aging results in molecular changes in an enriched population of undifferentiated rat spermatogonia.

    Science.gov (United States)

    Paul, Catriona; Nagano, Makoto; Robaire, Bernard

    2013-12-01

    A strong correlation exists between increasing paternal age and a decline in reproductive function. Testis aging is associated with testicular atrophy, increased DNA damage, and de novo mutations. It is unclear whether these problems arise from the spermatogonial stem cells (SSCs), a buildup of anomalies as older germ cells progress through spermatogenesis, or both. We hypothesize that with the continual divisions of SSCs that maintain the germ cell population, an alteration of these cells occurs over time. To test this, we utilized young (4-mo-old) and aged (18- and 21-mo-old) transgenic rats that express GFP in germ cells only. We first examined the number and activity of SSCs from the different age groups by transplantation. Aged rats had numerically fewer SSCs than young rats (age, we isolated an SSC-enriched population of CD9-positive (CD9(+)) cells using fluorescence-activated cell sorting (confirmed by transplantation studies) and extracted RNA for microarray analysis. In the aged CD9(+) cells, 60 transcripts were upregulated and more than 500 downregulated compared to the young cells. An altered expression was found for transcripts involved in mitosis and in DNA damage response. These results suggest molecular alterations in the SSC-enriched population of aged CD9(+) cells, implying that reproductive aging originates in the undifferentiated cells of spermatogenesis.

  11. Biodistribution of p-borophenylalanine (BPA) in dogs with spontaneous undifferentiated thyroid carcinoma (UTC)

    International Nuclear Information System (INIS)

    Dagrosa, M.A.; Viaggi, M.; Rebagliati, R. Jimenez; Castillo, V.A.; Batistoni, D.; Cabrini, R.L.; Castiglia, S.; Juvenal, G.J.; Pisarev, M.A.

    2004-01-01

    Human undifferentiated thyroid carcinoma (UTC) is a very aggressive tumor which lacks an adequate treatment. The UTC human cell line ARO has a selective uptake of BPA in vitro and after transplanting into nude mice. Applications of boron neutron capture therapy (BNCT) to mice showed a 100% control of growth and a 50% histological cure of tumors with an initial volume of 50 mm 3 or less. As a further step towards the potential application in humans we have performed the present studies. Four dogs with diagnosis of spontaneous UTC were studied. A BPA-fructose solution was infused during 60 min and dogs were submitted to thyroidectomy. Samples of blood and from different areas of the tumors (and in one dog from normal thyroid) were obtained and the boron was determined by ICP-OES. Selective BPA uptake by the tumor was found in all animals, the tumor/blood ratios ranged between 2.02 and 3.76, while the tumor/normal thyroid ratio was 6.78. Individual samples had tumor/blood ratios between 8.36 and 0.33. These ratios were related to the two histological patterns observed: homogeneous and heterogeneous tumors. We confirm the selective uptake of BPA by spontaneous UTC in dogs and plan to apply BNCT in the future

  12. Application of a prediction model for the progression of rheumatoid arthritis in patients with undifferentiated arthritis.

    Science.gov (United States)

    Arana-Guajardo, Ana; Pérez-Barbosa, Lorena; Vega-Morales, David; Riega-Torres, Janett; Esquivel-Valerio, Jorge; Garza-Elizondo, Mario

    2014-01-01

    Different prediction rules have been applied to patients with undifferentiated arthritis (UA) to identify those that progress to rheumatoid arthritis (RA). The Leiden Prediction Rule (LPR) has proven useful in different UA cohorts. To apply the LPR to a cohort of patients with UA of northeastern Mexico. We included 47 patients with UA, LPR was applied at baseline. They were evaluated and then classified after one year of follow-up into two groups: those who progressed to RA (according to ACR 1987) and those who did not. 43% of the AI patients developed RA. In the RA group, 56% of patients obtained a score ≤ 6 and only 15% ≥ 8. 70% who did not progress to RA had a score between 6 and ≤ 8. There was no difference in median score of LPR between groups, p=0.940. Most patients who progressed to RA scored less than 6 points in the LPR. Unlike what was observed in other cohorts, the model in our population did not allow us to predict the progression of the disease. Copyright © 2013 Elsevier España, S.L.U. All rights reserved.

  13. Isolated Ro52 Antibodies as Immunological Marker of a Mild Phenotype of Undifferentiated Connective Tissue Diseases

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    Ana Alonso-Larruga

    2017-01-01

    Full Text Available The term undifferentiated connective tissue disease (UCTD is used to describe undiagnosed patients that do not fulfill classification criteria for definite connective tissue disease (Systemic Lupus, Systemic Sclerosis, Sjögren Syndrome, and Dermatomyositis/Polymyositis. It is important to find serological markers as predictors of the evolution or severity of these diseases. The objective of this retrospective study was to investigate if there was a milder subgroup of UCTD with a special clinical profile consisting only in the presence of anti-Ro52 autoantibodies. Immunological and clinical records of 62 patients attending the hospital during 30 months were studied. Results showed a target population formed by mostly women, aged between 40 and 80 years at the moment of the study, with a registered age of onset between 40 and 60 years. Speckled pattern was the most frequent pattern found by indirect immunofluorescence. Given the obtained results and keeping in mind possible limitations because of sample size, isolated positive anti-Ro52 autoantibodies seem to lead to a benign effect in terms of evolution of the disease. As a future objective, the follow-up of these patients should be necessary to investigate new clinical symptoms, serological markers, or development of a definite connective tissue disease over time.

  14. Proteomic analysis of plasma membranes isolated from undifferentiated and differentiated HepaRG cells

    Directory of Open Access Journals (Sweden)

    Sokolowska Izabela

    2012-08-01

    Full Text Available Abstract Liver infection with hepatitis B virus (HBV, a DNA virus of the Hepadnaviridae family, leads to severe disease, such as fibrosis, cirrhosis and hepatocellular carcinoma. The early steps of the viral life cycle are largely obscure and the host cell plasma membrane receptors are not known. HepaRG is the only proliferating cell line supporting HBV infection in vitro, following specific differentiation, allowing for investigation of new host host-cell factors involved in viral entry, within a more robust and reproducible environment. Viral infection generally begins with receptor recognition at the host cell surface, following highly specific cell-virus interactions. Most of these interactions are expected to take place at the plasma membrane of the HepaRG cells. In the present study, we used this cell line to explore changes between the plasma membrane of undifferentiated (− and differentiated (+ cells and to identify differentially-regulated proteins or signaling networks that might potentially be involved in HBV entry. Our initial study identified a series of proteins that are differentially expressed in the plasma membrane of (− and (+ cells and are good candidates for potential cell-virus interactions. To our knowledge, this is the first study using functional proteomics to study plasma membrane proteins from HepaRG cells, providing a platform for future experiments that will allow us to understand the cell-virus interaction and mechanism of HBV viral infection.

  15. Scattering from Rock and Rock Outcrops

    Science.gov (United States)

    2018-01-23

    of the open questions which exist for scattering from these types of surfaces and include increasing our basic understanding of: (1) geoacoustic...ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) Office of Naval Research 875 North Randolph Street ...ideal mean seafloor could be mapped to the local SCATTERING FROM ROCKS 5 Figure 4. (color online) SAS images of the calibration rock outcrop. Boxes

  16. Diagnostic and predictive value of acute-phase reactants in adult undifferentiated peripheral inflammatory arthritis: a systematic review.

    Science.gov (United States)

    Vercoutere, Ward; Thevissen, Kristof; Bombardier, Claire; Landewé, Robert B M

    2011-03-01

    To review the available literature on the diagnostic and predictive value of acute-phase reactants in adult undifferentiated peripheral inflammatory arthritis (UPIA) as an evidence base for generating multinational clinical practice recommendations in the 3e Initiative in Rheumatology. A systematic literature search was carried out using Medline, Embase, the Cochrane Library, and abstracts presented at the 2007 and 2008 meetings of the American College of Rheumatology and European League Against Rheumatism, searching for prognostic and diagnostic markers of acute-phase reactants in adult UPIA. Articles that fulfilled predefined inclusion criteria were systematically reviewed, and the quality was appraised. Likelihood ratios (LR), sensitivity, and specificity for diagnostic and prognostic outcomes were calculated. A total of 18 publications out of 3699 identified references were included in the review. Only a small number of studies with significant heterogeneity, including different outcome measures and different cutoff values, were eligible for review, so pooling data was not possible. Overall, LR showed poor diagnostic and prognostic performance for most investigated acute-phase reactants. Available data showed some value for erythrocyte sedimentation rate in establishing a diagnosis in patients with undifferentiated arthritis; some prognostic and diagnostic value for C-reactive protein; some prognostic value for plasma viscosity in predicting persistence of arthritis; and some diagnostic value for sulfhydryl levels and matrix metalloproteinase-3 in establishing a diagnosis of rheumatoid arthritis. There is little published evidence concerning the diagnostic and predictive value of acute-phase reactants in patients with UPIA. Studies were heterogeneous, and "undifferentiated arthritis" was not well defined or was equivocally defined. The role of acute-phase reactants in diagnosing and predicting outcome in patients presenting with undifferentiated arthritis is

  17. A Predictive Model to Classify Undifferentiated Fever Cases Based on Twenty-Four-Hour Continuous Tympanic Temperature Recording

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    Pradeepa H. Dakappa

    2017-01-01

    Full Text Available Diagnosis of undifferentiated fever is a major challenging task to the physician which often remains undiagnosed and delays the treatment. The aim of the study was to record and analyze a 24-hour continuous tympanic temperature and evaluate its utility in the diagnosis of undifferentiated fevers. This was an observational study conducted in the Kasturba Medical College and Hospitals, Mangaluru, India. A total of ninety-six (n=96 patients were presented with undifferentiated fever. Their tympanic temperature was recorded continuously for 24 hours. Temperature data were preprocessed and various signal characteristic features were extracted and trained in classification machine learning algorithms using MATLAB software. The quadratic support vector machine algorithm yielded an overall accuracy of 71.9% in differentiating the fevers into four major categories, namely, tuberculosis, intracellular bacterial infections, dengue fever, and noninfectious diseases. The area under ROC curve for tuberculosis, intracellular bacterial infections, dengue fever, and noninfectious diseases was found to be 0.961, 0.801, 0.815, and 0.818, respectively. Good agreement was observed [kappa = 0.618 (p<0.001, 95% CI (0.498–0.737] between the actual diagnosis of cases and the quadratic support vector machine learning algorithm. The 24-hour continuous tympanic temperature recording with supervised machine learning algorithm appears to be a promising noninvasive and reliable diagnostic tool.

  18. A Predictive Model to Classify Undifferentiated Fever Cases Based on Twenty-Four-Hour Continuous Tympanic Temperature Recording.

    Science.gov (United States)

    Dakappa, Pradeepa H; Prasad, Keerthana; Rao, Sathish B; Bolumbu, Ganaraja; Bhat, Gopalkrishna K; Mahabala, Chakrapani

    2017-01-01

    Diagnosis of undifferentiated fever is a major challenging task to the physician which often remains undiagnosed and delays the treatment. The aim of the study was to record and analyze a 24-hour continuous tympanic temperature and evaluate its utility in the diagnosis of undifferentiated fevers. This was an observational study conducted in the Kasturba Medical College and Hospitals, Mangaluru, India. A total of ninety-six ( n = 96) patients were presented with undifferentiated fever. Their tympanic temperature was recorded continuously for 24 hours. Temperature data were preprocessed and various signal characteristic features were extracted and trained in classification machine learning algorithms using MATLAB software. The quadratic support vector machine algorithm yielded an overall accuracy of 71.9% in differentiating the fevers into four major categories, namely, tuberculosis, intracellular bacterial infections, dengue fever, and noninfectious diseases. The area under ROC curve for tuberculosis, intracellular bacterial infections, dengue fever, and noninfectious diseases was found to be 0.961, 0.801, 0.815, and 0.818, respectively. Good agreement was observed [kappa = 0.618 ( p machine learning algorithm. The 24-hour continuous tympanic temperature recording with supervised machine learning algorithm appears to be a promising noninvasive and reliable diagnostic tool.

  19. Comparison of the gene expression profile of undifferentiated human embryonic stem cell lines and differentiating embryoid bodies

    Directory of Open Access Journals (Sweden)

    Rao Mahendra S

    2005-10-01

    Full Text Available Abstract Background The identification of molecular pathways of differentiation of embryonic stem cells (hESC is critical for the development of stem cell based medical therapies. In order to identify biomarkers and potential regulators of the process of differentiation, a high quality microarray containing 16,659 seventy base pair oligonucleotides was used to compare gene expression profiles of undifferentiated hESC lines and differentiating embryoid bodies. Results Previously identified "stemness" genes in undifferentiated hESC lines showed down modulation in differentiated cells while expression of several genes was induced as cells differentiated. In addition, a subset of 194 genes showed overexpression of greater than ≥ 3 folds in human embryoid bodies (hEB. These included 37 novel and 157 known genes. Gene expression was validated by a variety of techniques including another large scale array, reverse transcription polymerase chain reaction, focused cDNA microarrays, massively parallel signature sequencing (MPSS analysis and immunocytochemisty. Several novel hEB specific expressed sequence tags (ESTs were mapped to the human genome database and their expression profile characterized. A hierarchical clustering analysis clearly depicted a distinct difference in gene expression profile among undifferentiated and differentiated hESC and confirmed that microarray analysis could readily distinguish them. Conclusion These results present a detailed characterization of a unique set of genes, which can be used to assess the hESC differentiation.

  20. Comparison of the gene expression profile of undifferentiated human embryonic stem cell lines and differentiating embryoid bodies.

    Science.gov (United States)

    Bhattacharya, Bhaskar; Cai, Jingli; Luo, Youngquan; Miura, Takumi; Mejido, Josef; Brimble, Sandii N; Zeng, Xianmin; Schulz, Thomas C; Rao, Mahendra S; Puri, Raj K

    2005-10-05

    The identification of molecular pathways of differentiation of embryonic stem cells (hESC) is critical for the development of stem cell based medical therapies. In order to identify biomarkers and potential regulators of the process of differentiation, a high quality microarray containing 16,659 seventy base pair oligonucleotides was used to compare gene expression profiles of undifferentiated hESC lines and differentiating embryoid bodies. Previously identified "stemness" genes in undifferentiated hESC lines showed down modulation in differentiated cells while expression of several genes was induced as cells differentiated. In addition, a subset of 194 genes showed overexpression of greater than > or = 3 folds in human embryoid bodies (hEB). These included 37 novel and 157 known genes. Gene expression was validated by a variety of techniques including another large scale array, reverse transcription polymerase chain reaction, focused cDNA microarrays, massively parallel signature sequencing (MPSS) analysis and immunocytochemisty. Several novel hEB specific expressed sequence tags (ESTs) were mapped to the human genome database and their expression profile characterized. A hierarchical clustering analysis clearly depicted a distinct difference in gene expression profile among undifferentiated and differentiated hESC and confirmed that microarray analysis could readily distinguish them. These results present a detailed characterization of a unique set of genes, which can be used to assess the hESC differentiation.

  1. Conditionally replicating adenovirus prevents pluripotent stem cell–derived teratoma by specifically eliminating undifferentiated cells

    Directory of Open Access Journals (Sweden)

    Kaoru Mitsui

    Full Text Available Incomplete abolition of tumorigenicity creates potential safety concerns in clinical trials of regenerative medicine based on human pluripotent stem cells (hPSCs. Here, we demonstrate that conditionally replicating adenoviruses that specifically target cancers using multiple factors (m-CRAs, originally developed as anticancer drugs, may also be useful as novel antitumorigenic agents in hPSC-based therapy. The survivin promoter was more active in undifferentiated hPSCs than the telomerase reverse transcriptase (TERT promoter, whereas both promoters were minimally active in differentiated normal cells. Accordingly, survivin-responsive m-CRA (Surv.m-CRA killed undifferentiated hPSCs more efficiently than TERT-responsive m-CRAs (Tert.m-CRA; both m-CRAs exhibited efficient viral replication and cytotoxicity in undifferentiated hPSCs, but not in cocultured differentiated normal cells. Pre-infection of hPSCs with Surv.m-CRA or Tert.m-CRA abolished in vivo teratoma formation in a dose-dependent manner following hPSC implantation into mice. Thus, m-CRAs, and in particular Surv.m-CRAs, represent novel antitumorigenic agents that could facilitate safe clinical applications of hPSC-based regenerative medicine.

  2. Transcription profiling by array of the response of Arabidopsis cultivar Columbia etiolated seedlings and undifferentiated tissue culture cells to the spaceflight environment

    Data.gov (United States)

    National Aeronautics and Space Administration — We address a key baseline question of whether gene expression changes are induced by the orbital environment and then we ask whether undifferentiated cells cells...

  3. Protective Role of Hypothermia Against Heat Stress in Differentiated and Undifferentiated Human Neural Precursor Cells: A Differential Approach for the Treatment of Traumatic Brain Injury

    Directory of Open Access Journals (Sweden)

    Sandeep Kumar Vishwakarma

    2017-11-01

    Conclusion: Mild-hypothermia treatment induces attenuated heat shock response against heat stress resulting in induced HSP-70 expression that significantly improves structure and function of both undifferentiated human NPCs and differentiated neurons.

  4. Clinical, epidemiological and virological features of dengue virus infections in vietnamese patients presenting to primary care facilities with acute undifferentiated fever

    NARCIS (Netherlands)

    Thai, Khoa T. D.; Phuong, Hoang Lan; Thanh Nga, Tran Thi; Giao, Phan Trong; Hung, Le Quoc; van Nam, Nguyen; Binh, Tran Quang; Simmons, Cameron; Farrar, Jeremy; Hien, Tran Thinh; Rogier van Doorn, H.; de Jong, Menno D.; de Vries, Peter J.

    2010-01-01

    Objectives: To explore clinical and virological characteristics and describe the epidemiology of dengue in patients who presented with acute undifferentiated fever (AUF) at primary health centers (PHC) in Binh Thuan Province, Vietnam. Methods: A prospective observational study was conducted from

  5. Vegetative status characteristics in children with neurological pathology on the background of undifferentiated connective tissue dysplasia

    Directory of Open Access Journals (Sweden)

    Tyazka O.V.

    2016-03-01

    Full Text Available Background. Disorders of the autonomic nervous system are the most common pathological conditions detected in 20% - 85% of children and adolescents according to different authors' data. Assessment of the vegetative status in the period of intensive growth and differentiation of organs and tissues that is characteristic of childhood is of great practical importance. Identification of vegetative dysregulation is an important diagnostic measure in children's health status evaluation especially in patients with undifferentiated connective tissue dysplasia (UNDCT taking into account its genetic determinism and debut in childhood. Genetically determined biochemical disorders in the connective tissue followed by formation of characteristic pathological substrates cause dysregulation of sympathoadrenal system and correlate with UNDCT severity degree. Material and methods. There were 100 children aged from 5 to 16 years engaged in the investigation. All of them were treated in the neurological department of the City clinical hospital №4. All patients were divided into two groups: basic group, which included 50 children with neurological disorders and UNDC, and control one, which consisted of 50 children with neurological disorders without UNDCT. The survey included obstetric history analysis, anthropometry to determine the ratio of longitudinal and transverse dimensions (the index of Vervica; clinical and neurological examination (study of reflex&motor areas, sensory function, coordination; laboratory methods (clinical blood count and biochemical blood tests to determine the level of potassium and calcium ions, instrumental methods (electroencephalography, rheoencephalography, magnetic resonance imaging of the brain. Osokina's table was used for baseline autonomic tone assessment. The evaluation was conducted by counting the number of signs. Subsequently was performed the summation of the scores with the determination of the percentage of predominant

  6. ARG1 Functions in the Physiological Adaptation of Undifferentiated Plant Cells to Spaceflight

    Science.gov (United States)

    Zupanska, Agata K.; Schultz, Eric R.; Yao, JiQiang; Sng, Natasha J.; Zhou, Mingqi; Callaham, Jordan B.; Ferl, Robert J.; Paul, Anna-Lisa

    2017-11-01

    Scientific access to spaceflight and especially the International Space Station has revealed that physiological adaptation to spaceflight is accompanied or enabled by changes in gene expression that significantly alter the transcriptome of cells in spaceflight. A wide range of experiments have shown that plant physiological adaptation to spaceflight involves gene expression changes that alter cell wall and other metabolisms. However, while transcriptome profiling aptly illuminates changes in gene expression that accompany spaceflight adaptation, mutation analysis is required to illuminate key elements required for that adaptation. Here we report how transcriptome profiling was used to gain insight into the spaceflight adaptation role of Altered response to gravity 1 (Arg1), a gene known to affect gravity responses in plants on Earth. The study compared expression profiles of cultured lines of Arabidopsis thaliana derived from wild-type (WT) cultivar Col-0 to profiles from a knock-out line deficient in the gene encoding ARG1 (ARG1 KO), both on the ground and in space. The cell lines were launched on SpaceX CRS-2 as part of the Cellular Expression Logic (CEL) experiment of the BRIC-17 spaceflight mission. The cultured cell lines were grown within 60 mm Petri plates in Petri Dish Fixation Units (PDFUs) that were housed within the Biological Research In Canisters (BRIC) hardware. Spaceflight samples were fixed on orbit. Differentially expressed genes were identified between the two environments (spaceflight and comparable ground controls) and the two genotypes (WT and ARG1 KO). Each genotype engaged unique genes during physiological adaptation to the spaceflight environment, with little overlap. Most of the genes altered in expression in spaceflight in WT cells were found to be Arg1-dependent, suggesting a major role for that gene in the physiological adaptation of undifferentiated cells to spaceflight.

  7. Undifferentiated connective tissue disease and interstitial lung disease: Trying to define patterns.

    Science.gov (United States)

    Alberti, María Laura; Paulin, Francisco; Toledo, Heidegger Mateos; Fernández, Martín Eduardo; Caro, Fabián Matías; Rojas-Serrano, Jorge; Mejía, Mayra Edith

    To identify clinical or immunological features in patients with undifferentiated connective tissue disease (UCTD) associated interstitial lung disease (ILD), in order to group them and recognize different functional and high resolution computed tomography (HRCT) behavior. Retrospective cohort study. Patients meeting Kinder criteria for UCTD were included. We defined the following predictive variables: 'highly specific' connective tissue disease (CTD) manifestations (Raynaud's phenomenon, dry eyes or arthritis), high antinuclear antibody (ANA) titer (above 1: 320), and 'specific' ANA staining patterns (centromere, cytoplasmic and nucleolar patterns). We evaluated the following outcomes: change in the percentage of the predicted forced vital capacity (FVC%) during the follow-up period, and HRCT pattern. Sixty-six patients were included. Twenty-nine (43.94%) showed at least one 'highly specific' CTD manifestation, 16 (28.57%) had a 'specific' ANA staining pattern and 29 (43.94%) high ANA titer. Patients with 'highly specific' CTD manifestations were younger (mean [SD] 52 years [14.58] vs 62.08 years [9.46], P<.001), were more likely men (10.34% vs 48.65%, P<.001) and showed a smaller decline of the FVC% (median [interquartile range] 1% [-1 to 10] vs -6% [-16 to -4], P<.006). In the multivariate analysis, the presence of highly specific manifestations was associated with improvement in the FVC% (B coefficient of 13.25 [95% confidence interval, 2.41 to 24.09]). No association was observed in relation to the HRCT pattern. The presence of 'highly specific' CTD manifestations was associated with female sex, younger age and better functional behavior. These findings highlight the impact of the clinical features in the outcome of patients with UCTD ILD. Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.

  8. Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer

    Science.gov (United States)

    Asakawa, Yukiko; Ohtaka, Masahiko; Maekawa, Shinya; Fukasawa, Mitsuharu; Nakayama, Yasuhiro; Yamaguchi, Tatsuya; Inoue, Taisuke; Uetake, Tomoyoshi; Sakamoto, Minoru; Sato, Tadashi; Kawaguchi, Yoshihiko; Fujii, Hideki; Mochizuki, Kunio; Hada, Masao; Oyama, Toshio; Yasumura, Tomotaka; Omata, Kosaku; Nishiyama, Atsushi; Naito, Keiichi; Hata, Hideo; Haba, Yoshiaki; Miyata, Kazuyuki; Saitoh, Haruhisa; Yamadera, Yoichi; Miura, Kazuo; Kawaoi, Akira; Abe, Tohru; Tsunoda, Hajime; Honda, Yuji; Kurosaki, Masayuki; Enomoto, Nobuyuki

    2015-01-01

    AIM: To study how lymph node metastasis (LNM) risk is stratified in undifferentiated-type early gastric cancer (undiff-EGC) dependent on combinations of risk factors. METHODS: Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively. Using clinicopathological factors of patient age, location, size, an endoscopic macroscopic tumor form, ulceration, depth, histology, lymphatic involvement (LI) and venous involvement (VI), LNM risk was examined and stratified by conventional statistical analysis and data-mining analysis. RESULTS: LNM was positive in 44 of 567 cases (7.8%). Univariate analysis revealed > 2 cm, protrusion, submucosal (sm), mixed type, LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis. In preoperatively evaluable factors excluding LVI, sm and > 2 cm were independent factors. According to the depth and size, cases were categorized into the low-risk group [m and ≤ 2 cm, 0% (LNM incidence)], the moderate-risk group (m and > 2 cm, 5.6%; and sm and ≤ 2 cm, 6.0%), and the high-risk group (sm and > 2 cm, 19.3%). On the other hand, LNM occurred in 1.4% in all LI-negative cases, greatly lower than 28.2% in all LI-positive cases, and LNM incidence was low in LI-negative cases even in the moderate- and high-risk groups. CONCLUSION: LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively. Among these factors, LI was the most significantly correlated factor. PMID:25759537

  9. Radiation-induced apoptosis in undifferentiated cells of the developing brain as a biological defense mechanism

    International Nuclear Information System (INIS)

    Inouye, Minioru; Tamaru, Masao.

    1994-01-01

    Undifferentiated neural (UN) cells of the developing mammalian brain are highly sensitive to the lethal effects of ionizing radiation. Nuclear and cytoplasmic condensation, transglutaminase activation, and internucleosomal DNA cleavage reveal radiation-induced cell death in the ventricular zone of the cerebral mantle and external granular layer of the cerebellum to be due to apoptosis. A statistically significant increase of cell mortality can be induced by 0.03 Gy X-irradiation, and the mortality increases linearly with increasing doses. It is not changed by split doses, probably because of the very slow repair of cellular damage and a lack of adaptive response. Although extensive apoptosis in the UN cell population results in microcephaly and mental retardation, it possesses the ability to recover from a considerable cell loss and to form the normal structure of the central nervous system. The number of cell deaths needed to induce tissue adnormalities in the adult murine brain rises in the range of 15-25% of the germinal cell population; with the threshold doses at about 0.3 Gy for cerebral anomalies and 1 Gy for cerebellar abnormalities. Threshold level is similarly suggested in prenatally exposed A-bomb survivors. High radiosensitivity of UN cells is assumed to be a manifestation of the ability of the cell to commit suicide when injured. Repeated replication of DNA and extensive gene expression are required in future proliferation and differentiation. Once an abnormality in DNA was induced and fixed in the UN cell, it would be greatly amplified and prove a danger in producing malformations and tumors. These cells would thus commit suicide for the benefit of the individual to eliminate their acquired genetic abnormalities rather than make DNA repair. UN cells in the developing brain are highly radiosensitive and readily involved in apoptosis. Paradoxically, however, this may be to protect individuals against teratogenesis and tumorigenesis. (J.P.N.)

  10. CD133-expressing thyroid cancer cells are undifferentiated, radioresistant and survive radioiodide therapy

    Energy Technology Data Exchange (ETDEWEB)

    Ke, Chien-Chih [National Yang Ming University, Institute of Clinical Medicine, Taipei (China); Liu, Ren-Shyan [National Yang Ming University, Institute of Clinical Medicine, Taipei (China); NRPGM, Molecular and Genetic Imaging Core, Taipei (China); National Yang-Ming University, School of Medicine, Taipei (China); Taipei Veterans General Hospital, National PET/Cyclotron Center, Taipei (China); National Yang-Ming University, Department of Biomedical Imaging and Radiological Sciences, Taipei (China); Yang, An-Hang [Taipei Veterans General Hospital, Department of Pathology and Laboratory Medicine, Taipei (China); National Yang-Ming University, Department of Pathology, School of Medicine, Taipei (China); Liu, Ching-Sheng [National Yang-Ming University Medical School, Department of Nuclear Medicine, School of Medicine, Taipei (China); Chi, Chin-Wen [National Yang-Ming University, Institute of Pharmacology, School of Medicine, Taipei (China); Taipei Veterans General Hospital, Department of Medical Research and Education, Taipei (China); Tseng, Ling-Ming [National Yang Ming University, Institute of Clinical Medicine, Taipei (China); Taipei Veterans General Hospital, Department of Surgery, Taipei (China); Tsai, Yi-Fan [Taipei Veterans General Hospital, Department of Surgery, Taipei (China); Ho, Jennifer H. [Taipei Medical University, Graduate Institute of Clinical Medicine, Taipei (China); Taipei Medical University-Wan Fang Medical Center, Department of Ophthalmology, Taipei (China); Taipei Medical University-Wan Fang Medical Center, Center for Stem Cell Research, Taipei (China); Lee, Chen-Hsen [NRPGM, Molecular and Genetic Imaging Core, Taipei (China); National Yang-Ming University, School of Medicine, Taipei (China); Taipei Veterans General Hospital, Department of Surgery, Taipei (China); Lee, Oscar K. [Taipei Veterans General Hospital, Department of Orthopedics, Taipei (China); National Yang-Ming University, Stem Cell Research Center, Taipei (China); Taipei Veterans General Hospital, Department of Medical Research and Education, Taipei (China)

    2013-01-15

    {sup 131}I therapy is regularly used following surgery as a part of thyroid cancer management. Despite an overall relatively good prognosis, recurrent or metastatic thyroid cancer is not rare. CD133-expressing cells have been shown to mark thyroid cancer stem cells that possess the characteristics of stem cells and have the ability to initiate tumours. However, no studies have addressed the influence of CD133-expressing cells on radioiodide therapy of the thyroid cancer. The aim of this study was to investigate whether CD133{sup +} cells contribute to the radioresistance of thyroid cancer and thus potentiate future recurrence and metastasis. Thyroid cancer cell lines were analysed for CD133 expression, radiosensitivity and gene expression. The anaplastic thyroid cancer cell line ARO showed a higher percentage of CD133{sup +} cells and higher radioresistance. After {gamma}-irradiation of the cells, the CD133{sup +} population was enriched due to the higher apoptotic rate of CD133{sup -} cells. In vivo {sup 131}I treatment of ARO tumour resulted in an elevated expression of CD133, Oct4, Nanog, Lin28 and Glut1 genes. After isolation, CD133{sup +} cells exhibited higher radioresistance and higher expression of Oct4, Nanog, Sox2, Lin28 and Glut1 in the cell line or primarily cultured papillary thyroid cancer cells, and lower expression of various thyroid-specific genes, namely NIS, Tg, TPO, TSHR, TTF1 and Pax8. This study demonstrates the existence of CD133-expressing thyroid cancer cells which show a higher radioresistance and are in an undifferentiated status. These cells possess a greater potential to survive radiotherapy and may contribute to the recurrence of thyroid cancer. A future therapeutic approach for radioresistant thyroid cancer may focus on the selective eradication of CD133{sup +} cells. (orig.)

  11. Lower Cretaceous Source Rock and its Implication for the Gulf of Guinea Petroleum System

    International Nuclear Information System (INIS)

    Frost, B.R.; Griffith, R.C.

    2002-01-01

    Current petroleum system models for the Gulf of Guinea propose Tertiary-age deltaic organic material as the principal source for the hydrocarbons found there. Although previous workers recognized numerous difficulties and inconsistencies, no alternative model has been resented to adequately explain the complete petroleum system. We propose that the principal source rock for the Gulf of Guinea system occurs in upper lower Cretaceous-age shales at the rift-drift transition. Tertiary loading and the consequent maturation of this lower Cretaceous source rock can explain the controls on tap formation, reservoir distribution and hydrocarbon types found in the Gulf of Guinea

  12. Origin and significance of tourmalinites and tourmaline-bearing rocks of Menderes Massif, western Anatolia, Turkey

    OpenAIRE

    Yucel-ozturk, Yesim; Helvaci, Cahit; Palmer, Martin R.; Ersoy, E. Yalcin; Freslon, Nicolas

    2015-01-01

    In the western central portion of Anatolia lies the Menderes Massif – a large metamorphic crystalline complex made of Neoproterozoic to Precambrian basement rocks overlain by Palaeozoic to early Tertiary metasedimentary rocks, and with a multistage metamorphic evolution developed from the late Neo-Proterozoic to Eocene. We have undertaken a study of the petrology, geochemistry and boron isotope composition of these tourmaline occurrences aiming to constrain the processes responsible for the e...

  13. The educational needs of patients with undifferentiated spondyloarthritis: Validation of the ENAT questionnaire and needs assessment.

    Science.gov (United States)

    Bremander, A; Haglund, E; Bergman, S; Ndosi, M

    2018-02-07

    The aim of the present study was to validate the Swedish version of the educational needs assessment tool (SwENAT) in undifferentiated spondyloarthritis (USpA) and use it to study the educational needs of patients with USpA. This was a cross-sectional study, recruiting a random sample of patients with USpA from a hospital register in Sweden. Educational needs data were collected, together with disease activity and function indices (Bath Ankylosing Spondylitis Disease Activity Index [BASDAI] and Bath Ankylosing Spondylitis Functional Index [BASFI]). Rasch analysis was utilized to evaluate the construct validity, internal consistency and unidimensionality of the SwENAT before studying differences in educational needs between patient subgroups (gender, age and disease severity). Complete responses were obtained from 77 patients (48 women), with a mean age (standard deviation [SD]) of 50 (12) years, a disease duration of 16 (11) years, a BASDAI score of 4.9 (1.9) and a BASFI score of 3.1 (2.3). The SwENAT satisfied the requirements of the Rasch model (χ 2 = 11.488; p = 0.119), including strict unidimensionality. Overall, the mean (SD) SwENAT score was 86 (32). Women reported higher needs than men in the domains of pain (mean [SD] 13.1 [6.8] versus 10.1 [6.0]; p = 0.05); movement (mean [SD] 13.0 [5.5] versus 9.9 [5.7]; p = 0.02) and self-help (mean [SD] 17.0 [5.8] versus 14.1 [5.0]; p = 0.03). Higher disease activity (BASDAI >4) was associated with higher educational needs (mean [SD] 92.6 [31.9] versus 73.7 [29.4]; p = 0.02). These data suggest that the SwENAT is valid in USpA. Women and patients with higher disease activity are more likely to have high levels of educational needs, so special attention and strategies to target patient education are warranted. Copyright © 2018 John Wiley & Sons, Ltd.

  14. Parathyroid carcinoma in tertiary hyperparathyroidism.

    Science.gov (United States)

    Kim, Byung Seup; Ryu, Han Suk; Kang, Kyung Ho; Park, Sung Jun

    2016-10-01

    Parathyroid carcinoma is a rare disease of unknown etiology. This study presents a case of parathyroid carcinoma in a patient with tertiary hyperparathyroidism. Despite a successful kidney transplantation, the intact parathyroid hormone (iPTH) level of the patient was elevated consistently and could not be controlled by medical therapy. Due to the development of tertiary hyperparathyroidism with bone pain and osteoporosis, subtotal parathyroidectomy was performed 4 months after the kidney transplantation. Histological evaluation revealed that one of four parathyroid lesions was a parathyroid carcinoma, while the others were diffuse hyperplasia. Postoperative laboratory studies indicated a decreased level of iPTH. A positron emission tomography-computed tomography performed 6 months after the operation revealed no evidence of local recurrence or distant metastasis. Copyright © 2013. Published by Elsevier Taiwan.

  15. Tectonic framework of petroliferous rocks in Alaska: hydrocarbons

    Science.gov (United States)

    Grantz, Arthur; Kirschner, C.E.

    1976-01-01

    Alaska, which contains about 28% of the land and continental shelf of the United States, is estimated by the U.S. Geological Survey to contain about one third of the nation's undiscovered oil and about one sixth of its undiscovered natural gas. The Survey estimates that fields discovered in Alaska through 1972 ultimately may produce about 26 billion bbl of oil and 68 Tcf of natural gas. In northern Alaska, Paleozoic and Mesozoic shelf and slope carbonate and clastic rocks of the Brooks Range orogen were thrust relatively northward over the depressed south margin of the Paleozoic and Mesozoic Arctic platform. A foredeep, the Colville geosyncline, developed across the depressed margin of the platform in earliest Cretaceous time. Detritus from the Brooks Range filled the foredeep and prograded northward to fill the Cretaceous and Tertiary North Chukchi and Umiat-Camden basins and form the progradational Beaufort shelf. The largest petroleum reserves (Prudhoe Bay and associated fields) and the best prospects for additional large discoveries in Alaska lie in the areally extensive upper Paleozoic to Tertiary carbonate and clastic rocks of northern Alaska. In southern Alaska, a series of arc-trench systems developed on oceanic rocks during Jurassic and Cretaceous time. Between these arcs and the metamorphic (continental) terranes of east-central and northern Alaska, large back-arc and arc-trench gap basins received thick volcanic and detrital deposits. These deposits were extensively, and commonly intensely, deformed and disrupted by mid-Jurassic to Tertiary plutonism, Laramide oroclinal bending, wrench faulting, and arc-related compression. This deformation, coupled with low porosity (in part produced by diagenetic mobilization of labile constituents), has left these rocks with only modest, local prospects for petroleum. Laramide events compressed and consolidated ("continentalized") the late Mesozoic back-arc basin deposits and welded them to the older continental

  16. Expression of the chitinase family glycoprotein YKL-40 in undifferentiated, differentiated and trans-differentiated mesenchymal stem cells.

    Directory of Open Access Journals (Sweden)

    Daniel J Hoover

    Full Text Available The glycoprotein YKL-40 (CHI3L1 is a secreted chitinase family protein that induces angiogenesis, cell survival, and cell proliferation, and plays roles in tissue remodeling and immune regulation. It is expressed primarily in cells of mesenchymal origin, is overexpressed in numerous aggressive carcinomas and sarcomas, but is rarely expressed in normal ectodermal tissues. Bone marrow-derived mesenchymal stem cells (MSCs can be induced to differentiate into various mesenchymal tissues and trans-differentiate into some non-mesenchymal cell types. Since YKL-40 has been used as a mesenchymal marker, we followed YKL-40 expression as undifferentiated MSCs were induced to differentiate into bone, cartilage, and neural phenotypes. Undifferentiated MSCs contain significant levels of YKL-40 mRNA but do not synthesize detectable levels of YKL-40 protein. MSCs induced to differentiate into chondrocytes and osteocytes soon began to express and secrete YKL-40 protein, as do ex vivo cultured chondrocytes and primary osteocytes. In contrast, MSCs induced to trans-differentiate into neurons did not synthesize YKL-40 protein, consistent with the general absence of YKL-40 protein in normal CNS parenchyma. However, these trans-differentiated neurons retained significant levels of YKL-40 mRNA, suggesting the mechanisms which prevented YKL-40 translation in undifferentiated MSCs remained in place, and that these trans-differentiated neurons differ in at least this way from neurons derived from neuronal stem cells. Utilization of a differentiation protocol containing β-mercaptoethanol resulted in cells that expressed significant amounts of intracellular YKL-40 protein that was not secreted, which is not seen in normal cells. Thus the synthesis of YKL-40 protein is a marker for MSC differentiation into mature mesenchymal phenotypes, and the presence of untranslated YKL-40 mRNA in non-mesenchymal cells derived from MSCs reflects differences between differentiated and

  17. Randomised primary health center based interventions to improve the diagnosis and treatment of undifferentiated fever and dengue in Vietnam

    Directory of Open Access Journals (Sweden)

    Binh Tran Q

    2010-09-01

    Full Text Available Abstract Background Fever is a common reason for attending primary health facilities in Vietnam. Response of health care providers to patients with fever commonly consists of making a presumptive diagnosis and proposing corresponding treatment. In Vietnam, where malaria was brought under control, viral infections, notably dengue, are the main causes of undifferentiated fever but they are often misdiagnosed and inappropriately treated with antibiotics. This study investigate if educating primary health center (PHC staff or introducing rapid diagnostic tests (RDTs improve diagnostic resolution and accuracy for acute undifferentiated fever (AUF and reduce prescription of antibiotics and costs for patients. Methods In a PHC randomized intervention study in southern Vietnam, the presumptive diagnoses for AUF patients were recorded and confirmed by serology on paired (acute and convalescence sera. After one year, PHCs were randomized to four intervention arms: training on infectious diseases (A, the provision of RDTs (B, the combination (AB and control (C. The intervention lasted from 2002 until 2006. Results The frequency of the non-etiologic diagnosis "undifferentiated fever" decreased in group AB, and - with some delay- also in group B. The diagnosis "dengue" increased in group AB, but only temporarily, although dengue was the most common cause of fever. A correct diagnosis for dengue initially increased in groups AB and B but only for AB this was sustained. Antibiotics prescriptions increased in group C. During intervention it initially declined in AB with a tendency to increase afterwards; in B it gradually declined. There was a substantial increase of patients' costs in B. Conclusions The introduction of RDTs for infectious diseases such as dengue, through free market principles, does improve the quality of the diagnosis and decreases the prescription of antibiotics at the PHC level. However, the effect is more sustainable in combination with

  18. Randomised primary health center based interventions to improve the diagnosis and treatment of undifferentiated fever and dengue in Vietnam.

    Science.gov (United States)

    Phuong, Hoang L; Nga, Tran T T; Giao, Phan T; Hung, Le Q; Binh, Tran Q; Nam, Nguyen V; Nagelkerke, Nico; de Vries, Peter J

    2010-09-21

    Fever is a common reason for attending primary health facilities in Vietnam. Response of health care providers to patients with fever commonly consists of making a presumptive diagnosis and proposing corresponding treatment. In Vietnam, where malaria was brought under control, viral infections, notably dengue, are the main causes of undifferentiated fever but they are often misdiagnosed and inappropriately treated with antibiotics.This study investigate if educating primary health center (PHC) staff or introducing rapid diagnostic tests (RDTs) improve diagnostic resolution and accuracy for acute undifferentiated fever (AUF) and reduce prescription of antibiotics and costs for patients. In a PHC randomized intervention study in southern Vietnam, the presumptive diagnoses for AUF patients were recorded and confirmed by serology on paired (acute and convalescence) sera. After one year, PHCs were randomized to four intervention arms: training on infectious diseases (A), the provision of RDTs (B), the combination (AB) and control (C). The intervention lasted from 2002 until 2006. The frequency of the non-etiologic diagnosis "undifferentiated fever" decreased in group AB, and - with some delay- also in group B. The diagnosis "dengue" increased in group AB, but only temporarily, although dengue was the most common cause of fever. A correct diagnosis for dengue initially increased in groups AB and B but only for AB this was sustained. Antibiotics prescriptions increased in group C. During intervention it initially declined in AB with a tendency to increase afterwards; in B it gradually declined. There was a substantial increase of patients' costs in B. The introduction of RDTs for infectious diseases such as dengue, through free market principles, does improve the quality of the diagnosis and decreases the prescription of antibiotics at the PHC level. However, the effect is more sustainable in combination with training; without it RDTs lead to an excess of costs.

  19. Heating, cooling, and uplift during Tertiary time, northern Sangre de Cristo Range, Colorado ( USA).

    Science.gov (United States)

    Lindsay, D.A.; Andriessen, P.A.M.; Wardlaw, B.R.

    1986-01-01

    Paleozoic sedimentary rocks in a wide area of the northern Sangre de Cristo Range show effects of heating during Tertiary time. Heating is tentatively interpreted as a response to burial during Laramide folding and thrusting and also to high heat flow during Rio Grande rifting. Fission-track ages of apatite across a section of the range show that rocks cooled abruptly below 120oC, the blocking temperature for apatite, approx 19 Ma ago. Cooling was probably in response to rapid uplift and erosion of the northern Sangre de Cristo Range during early Rio Grande rifting.-from Authors

  20. Space Weathering of Rocks

    Science.gov (United States)

    Noble, Sarah

    2011-01-01

    Space weathering discussions have generally centered around soils but exposed rocks will also incur the effects of weathering. On the Moon, rocks make up only a very small percentage of the exposed surface and areas where rocks are exposed, like central peaks, are often among the least space weathered regions we find in remote sensing data. However, our studies of weathered Ap 17 rocks 76015 and 76237 show that significant amounts of weathering products can build up on rock surfaces. Because rocks have much longer surface lifetimes than an individual soil grain, and thus record a longer history of exposure, we can study these products to gain a deeper perspective on the weathering process and better assess the relative impo!1ance of various weathering components on the Moon. In contrast to the lunar case, on small asteroids, like Itokowa, rocks make up a large fraction of the exposed surface. Results from the Hayabusa spacecraft at Itokowa suggest that while the low gravity does not allow for the development of a mature regolith, weathering patinas can and do develop on rock surfaces, in fact, the rocky surfaces were seen to be darker and appear spectrally more weathered than regions with finer materials. To explore how weathering of asteroidal rocks may differ from lunar, a set of ordinary chondrite meteorites (H, L, and LL) which have been subjected to artificial space weathering by nanopulse laser were examined by TEM. NpFe(sup 0) bearing glasses were ubiquitous in both the naturally-weathered lunar and the artificially-weathered meteorite samples.

  1. Driving mechanism of low salinity flooding in carbonate rocks (SPE-174300-MS)

    NARCIS (Netherlands)

    Mahani, Hassan; Berg, Steffen; Keya, Arsene; Bartels, W.; Nasralla, Ramez; Rossen, William

    2015-01-01

    Several studies conducted mainly on the laboratory scale indicate that in carbonate rocks oil displacement can be influenced by the ionic composition of the brine, providing an opportunity to improve recovery by optimizing the brine mixture used in secondary or tertiary recovery. In industry this

  2. Rock kinoekraanil / Katrin Rajasaare

    Index Scriptorium Estoniae

    Rajasaare, Katrin

    2008-01-01

    7.-11. juulini kinos Sõprus toimuval filminädalal "Rock On Screen" ekraanile jõudvatest rockmuusikuid portreteerivatest filmidest "Lou Reed's Berlin", "The Future Is Unwritten: Joe Strummer", "Control: Joy Division", "Hurriganes", "Shlaager"

  3. Rock Equity Holdings, LLC

    Science.gov (United States)

    The EPA is providing notice of an Administrative Penalty Assessment in the form of an Expedited Storm Water Settlement Agreement against Rock Equity Holdings, LLC, for alleged violations at The Cove at Kettlestone/98th Street Reconstruction located at 3015

  4. Pop & rock / Berk Vaher

    Index Scriptorium Estoniae

    Vaher, Berk, 1975-

    2001-01-01

    Uute heliplaatide Redman "Malpractice", Brian Eno & Peter Schwalm "Popstars", Clawfinger "A Whole Lot of Nothing", Dario G "In Full Color", MLTR e. Michael Learns To Rock "Blue Night" lühitutvustused

  5. Innovative rock bed construction

    Energy Technology Data Exchange (ETDEWEB)

    Cook, J.

    1983-06-01

    A general discussion of the use of rock beds for heating and cooling thermal storage is particularized for design and construction in Phoenix, Arizona. The rock bed parameters for three two-story condominium apartments constructed in 1982 are discussed, including sizing criteria and original construction details. A revised construction method using gabions that are self-supporting chain link cylinders provided a much more economical construction method as well as other advantages of speed and structural flexibility.

  6. Rock and Soil Rheology

    Science.gov (United States)

    Cristescu, Nicolae; Ene, Horia I.

    The first part of the volume contains theoretical considerations of the physical properties of soils and rocks. Articles on the mechanical and kinematical behavior of rocks as well as mathematical models are the base for the understanding of the physical properties of natural systems. In the second part articles deal with experiments and applications regarding creep deformation of clay, underground cavities, tunnels and deformation of sand and lamistrine sediments.

  7. Basic rocks in Finland

    International Nuclear Information System (INIS)

    Piirainen, T.; Gehoer, S.; Iljina, M.; Kaerki, A.; Paakkola, J.; Vuollo, J.

    1992-10-01

    Basic igneous rocks, containing less than 52% SiO 2 , constitute an important part of the Finnish Archaean and Proterozoic crust. In the Archaean crust exist two units which contain the majority of the basic rocks. The Arcaean basic rocks are metavolcanics and situated in the Greenstone Belts of Eastern Finland. They are divided into two units. The greenstones of the lower one are tholeiites, komatiites and basaltic komatiites. The upper consists of bimodal series of volcanics and the basic rocks of which are Fe-tholeiites, basaltic komatiites and komatiites. Proterozoic basic rocks are divided into seven groups according to their ages. The Proterozoic igneous activity started by the volominous basic magmatism 2.44 Ga ago. During this stage formed the layered intrusions and related dykes in the Northern Finland. 2.2 Ga old basic rocks are situated at the margins of Karelian formations. 2.1 Ga aged Fe-tholeiitic magmatic activity is widespread in Eastern and Northern Finland. The basic rocks of 1.97 Ga age group are met within the Karelian Schist Belts as obducted ophiolite complexes but they occur also as tholeiitic diabase dykes cutting the Karelian schists and Archean basement. The intrusions and the volcanics of the 1.9 Ga old basic igneous activity are mostly encountered around the Granitoid Complex of Central Finland. Subjotnian, 1.6 Ga aged tholeiitic diabases are situated around the Rapakivi massifs of Southern Finland, and postjotnian, 1.2 Ga diabases in Western Finland where they form dykes cutting Svecofennian rocks

  8. Undifferentiated bronchial fibroblasts derived from asthmatic patients display higher elastic modulus than their non-asthmatic counterparts.

    Science.gov (United States)

    Sarna, Michal; Wojcik, Katarzyna A; Hermanowicz, Pawel; Wnuk, Dawid; Burda, Kvetoslava; Sanak, Marek; Czyż, Jarosław; Michalik, Marta

    2015-01-01

    During asthma development, differentiation of epithelial cells and fibroblasts towards the contractile phenotype is associated with bronchial wall remodeling and airway constriction. Pathological fibroblast-to-myofibroblast transition (FMT) can be triggered by local inflammation of bronchial walls. Recently, we have demonstrated that human bronchial fibroblasts (HBFs) derived from asthmatic patients display some inherent features which facilitate their FMT in vitro. In spite of intensive research efforts, these properties remain unknown. Importantly, the role of undifferentiated HBFs in the asthmatic process was systematically omitted. Specifically, biomechanical properties of undifferentiated HBFs have not been considered in either FMT or airway remodeling in vivo. Here, we combine atomic force spectroscopy with fluorescence microscopy to compare mechanical properties and actin cytoskeleton architecture of HBFs derived from asthmatic patients and non-asthmatic donors. Our results demonstrate that asthmatic HBFs form thick and aligned 'ventral' stress fibers accompanied by enlarged focal adhesions. The differences in cytoskeleton architecture between asthmatic and non-asthmatic cells correlate with higher elastic modulus of asthmatic HBFs and their increased predilection to TGF-β-induced FMT. Due to the obvious links between cytoskeleton architecture and mechanical equilibrium, our observations indicate that HBFs derived from asthmatic bronchi can develop considerably higher static tension than non-asthmatic HBFs. This previously unexplored property of asthmatic HBFs may be potentially important for their myofibroblastic differentiation and bronchial wall remodeling during asthma development.

  9. A case report of prostate cancer metastasis to the stomach resembling undifferentiated-type early gastric cancer.

    Science.gov (United States)

    Inagaki, Chiaki; Suzuki, Takuto; Kitagawa, Yoshiyasu; Hara, Taro; Yamaguchi, Taketo

    2017-08-07

    Occurrence of metastatic cancer to the stomach is rare, particularly in patients with prostate cancer. Gastric metastasis generally presents as a solitary and submucosal lesion with a central depression. We describe a case of gastric metastasis arising from prostate cancer, which is almost indistinguishable from the undifferentiated-type gastric cancer. A definitive diagnosis was not made until endoscopic resection. On performing both conventional and magnifying endoscopies, the lesion appeared to be slightly depressed and discolored area and it could not be distinguished from undifferentiated early gastric cancer. Biopsy from the lesion was negative for immunohistochemical staining of prostate-specific antigen, a sensitive and specific marker for prostate cancer. Thus, false initial diagnosis of an early primary gastric cancer was made and endoscopic submucosal dissection was performed. Pathological findings from the resected specimen aroused suspicion of a metastatic lesion. Consequently, immunostaining was performed. The lesion was positive for prostate-specific acid phosphatase and negative for prostate-specific antigen, cytokeratin 7, and cytokeratin 20. Accordingly, the final diagnosis was a metastatic gastric lesion originating from prostate cancer. In this patient, the definitive diagnosis as a metastatic lesion was difficult due to its unusual endoscopic appearance and the negative stain for prostate-specific antigen. We postulate that both of these are consequences of hormonal therapy against prostate cancer.

  10. Malignant phyllodes tumor with heterologous differentiation: Clinicopathological spectrum of nine cases in a tertiary care institute in Eastern India

    Directory of Open Access Journals (Sweden)

    Mamita Nayak

    2017-01-01

    Full Text Available Phyllodes tumors are uncommon fibroepithelial neoplasms of breast. Heterologous sarcomatous differentiation of malignant phyllodes tumor (MPT is a rare phenomenon as shown in the literature. Herein we report a series of nine cases from a tertiary care centre in Eastern India. Patients demographic data and clinical details were obtained from the medical records. Histopathology and immunohistochemical studies were analysed and diagnosed accordingly. Out of 38 cases of PT, 13 were found to be MPT, of which 9 cases showed heterologous differentiation in the form of angiosarcoma, fibrosarcoma, undifferentiated sarcoma, extensive squamous differentiation and with lipomatous metaplasia. Proper diagnosis and subtyping of the sarcomatous component is essential for deciding the correct treatment modality and prognostication of the disease. However there is no clear cut treatment protocol is available because of paucity of data.

  11. Rock magnetic properties

    International Nuclear Information System (INIS)

    Hearst, R.B.; Morris, W.A.

    1991-01-01

    In 1978 the Nuclear Fuel Waste Management Program began the long task of site selection and evaluation for nuclear waste disposal. The Canadian Nuclear Fuel Waste Management Program, administered by Atomic Energy of Canada Limited, Research Company has provided the geophysicist with the unique opportunity to evaluate many modes of geophysical investigation in conjunction with detailed geologic mapping at a number of research areas. Of particular interest is research area RA-7, East Bull Lake, Algoma District, Ontario. Geophysical survey methods applied to the study of this included detailed gravity, ground magnetics, VLF, an airborne magnetic gradiometer survey and an airborne helicopter magnetic and EM survey. A comprehensive suite of rock property studies was also undertaken providing information on rock densities and magnetic rock properties. Preliminary modeling of the magnetic data sets assuming only induced magnetization illustrated the difficulty of arriving at a magnetic source geometry consistent with the mapped surficial and borehole geology. Integration of the magnetic rock properties observations and industry standard magnetic modelling techniques provides a source model geometry that is consistent with other geophysical/geological data sets, e.g. gravity and observed geology. The genesis of individual magnetic signatures in the East Bull Lake gabbro-anorthosite record the intrusion, metamorphism and fracture alteration of the pluton. As shown by this paper, only by understanding the rock magnetic signatures associated with each of these events is it possible to obtain geologically meaningful interpretative models

  12. Extraterrestrial cause for the Cretaceous-Tertiary extinction

    International Nuclear Information System (INIS)

    Alvarez, L.W.; Alvarez, W.; Asaro, F.; Michel, H.V.

    1980-01-01

    Platinum metals are depleted in the earth's crust relative to their cosmic abundance; concentrations of these elements in deep-sea sediments may thus indicate influxes of extraterrestrial material. Deep-sea limestones exposed in Italy, Denmark, and New Zealand show iridium increases of about 30, 160, and 20 times, respectively, above the background level at precisely the time of the Cretaceous-Tertiary extinctions, 65 million years ago. Reasons are given to indicate that this iridium is of extraterrestrial origin, but did not come from a nearby supernova. A hypothesis is suggested which accounts for the extinctions and the iridium observations. Impact of a large earth-crossing asteroid would inject about 60 times the object's mass into the atmosphere as pulverized rock; a fraction of this dust would stay in the stratosphere for several years and be distributed worldwide. The resulting darkness would suppress photosynthesis, and the expected biological consequences match quite closely the extinctions observed in the paleontological record. One prediction of this hypothesis has been verified: the chemical composition of the boundary clay, which is thought to come from the stratospheric dust, is markedly different from that of clay mixed with the Cretaceous and Tertiary limestones, which are chemically similar to each other. Four different independent estimates of the diameter of the asteroid give values that lie in the range 10 +- 4 kilometers

  13. Hydrochemical synthesis Northern Switzerland: tertiary- and Malm-aquifers

    International Nuclear Information System (INIS)

    Schmassmann, H.; Kullin, M.; Wexsteen, P.

    1990-05-01

    This Tertiary-Malm synthesis represents the first part of an overall hydrochemical synthesis of deep groundwaters in Northern Switzerland and adjacent areas. The investigation is mainly based on data from Nagra deep boreholes, from Nagra regional programme as well as from external sources. The first part provides a hydrogeological overview including a brief description of the aquifer rocks. A compilation of all existing hydraulic potential data is given and discussed for Northern Switzerland, Bodensee area and western Swabian Alb. In the Molasse Basin, hydrochemical and isotope analyses allowed a distinction of three main water types positioned one upon another: calcium-magnesium-bicarbonate groundwaters, sodium-bicarbonate and sodium-chloride deep groundwaters. Hydrochemical and isotopegeochemical details of these three water types comprise the major part of this report. Unlike the other two water types, the calcium-magnesium-bicarbonate groundwaters also include shallow waters with considerable tritium activities, indicating a mean residence time of less than 35 years. The spacial distribution of these three water types are demonstrated and different secular flow models in the Tertiary-Malm Aquifer group are discussed. (author) figs., tabs., 194 refs

  14. Extraterrestrial cause for the cretaceous-tertiary extinction.

    Science.gov (United States)

    Alvarez, L W; Alvarez, W; Asaro, F; Michel, H V

    1980-06-06

    Platinum metals are depleted in the earth's crust relative to their cosmic abundance; concentrations of these elements in deep-sea sediments may thus indicate influxes of extraterrestrial material. Deep-sea limestones exposed in Italy, Denmark, and New Zealand show iridium increases of about 30, 160, and 20 times, respectively, above the background level at precisely the time of the Cretaceous-Tertiary extinctions, 65 million years ago. Reasons are given to indicate that this iridium is of extraterrestrial origin, but did not come from a nearby supernova. A hypothesis is suggested which accounts for the extinctions and the iridium observations. Impact of a large earth-crossing asteroid would inject about 60 times the object's mass into the atmosphere as pulverized rock; a fraction of this dust would stay in the stratosphere for several years and be distributed worldwide. The resulting darkness would suppress photosynthesis, and the expected biological consequences match quite closely the extinctions observed in the paleontological record. One prediction of this hypothesis has been verified: the chemical composition of the boundary clay, which is thought to come from the stratospheric dust, is markedly different from that of clay mixed with the Cretaceous and Tertiary limestones, which are chemically similar to each other. Four different independent estimates of the diameter of the asteroid give values that lie in the range 10 +/- 4 kilometers.

  15. Learning Enhancement in Tertiary Institutions Using Mobile ...

    African Journals Online (AJOL)

    2012-12-01

    Dec 1, 2012 ... Abstract. The educational standard in tertiary institutions has witnessed a down turn in the area of teaching and learning. This paper links this down fall to traditional face-to-face educational model that is still by far the dominant mode of education and learning in tertiary institutions. In addition to identifying ...

  16. Tertiary Education Fees Public Opinion Poll, Australia.

    Science.gov (United States)

    McNair Anderson Associates Pty., Ltd., (Australia).

    The public reaction to the proposal that the Australian government should reintroduce fees for tertiary education was surveyed in 1985. The influence of the proposal on the way people would vote in a federal election was also investigated. The fee would be between $900 and $1,500 per year for full-time tertiary education. As part of a McNair…

  17. Studies on the Neogene Tertiary strata distributed in the central part of Tottori prefecture

    International Nuclear Information System (INIS)

    Yoshitani, Akihiko; Yoshizawa, Junko.

    1978-01-01

    The Neogene Tertiary strata, distributed in the central part of Tottori Prefecture, are volcano-stratigraphically classified, as shown in Figure 3. The Miocene strata are divided into Ojika formation and Mitoku formation in ascending order. Ojika formation, composed of plagio-rhyolitic pyroclastics and lavas, abuts against the basement rocks. Furthermore, some breaccias derived from the talus basal conglomerate beds are found in Ojika formation. Mitoku formation abuts both against the basement rocks and Ojika formation, and sometimes overlaps on the basement rocks. From the investigation into the Miocene strata, it is clarified that the depression took place prior to the volcanic activities at the earliest stage of the present Miocene sedimentary basin. (author)

  18. Sedimentary Rocks and Dunes

    Science.gov (United States)

    2004-01-01

    25 November 2004 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows buttes composed of light-toned, sedimentary rock exposed by erosion within a crater occurring immediately west of Schiaparelli Basin near 4.0oS, 347.9oW. Surrounding these buttes is a field of dark sand dunes and lighter-toned, very large windblown ripples. The sedimentary rocks might indicate that the crater interior was once the site of a lake. The image covers an area about 3 km (1.9 mi) wide. Sunlight illuminates the scene from the lower left.

  19. Session: Hard Rock Penetration

    Energy Technology Data Exchange (ETDEWEB)

    Tennyson, George P. Jr.; Dunn, James C.; Drumheller, Douglas S.; Glowka, David A.; Lysne, Peter

    1992-01-01

    This session at the Geothermal Energy Program Review X: Geothermal Energy and the Utility Market consisted of five presentations: ''Hard Rock Penetration - Summary'' by George P. Tennyson, Jr.; ''Overview - Hard Rock Penetration'' by James C. Dunn; ''An Overview of Acoustic Telemetry'' by Douglas S. Drumheller; ''Lost Circulation Technology Development Status'' by David A. Glowka; ''Downhole Memory-Logging Tools'' by Peter Lysne.

  20. Multinational evidence-based recommendations on how to investigate and follow-up undifferentiated peripheral inflammatory arthritis

    DEFF Research Database (Denmark)

    Machado, P; Castrejon, I; Katchamart, W

    2011-01-01

    OBJECTIVE: To develop evidence-based recommendations on how to investigate and follow-up undifferentiated peripheral inflammatory arthritis (UPIA). METHODS: 697 rheumatologists from 17 countries participated in the 3E (Evidence, Expertise, Exchange) Initiative of 2008-9 consisting of three separate......, of which 250 were systematically reviewed. Ten multinational key recommendations about the investigation and follow-up of UPIA were formulated. One recommendation addressed differential diagnosis and investigations prior to establishing the operational diagnosis of UPIA, seven recommendations related......) and the final recommendation addressed monitoring of clinical disease activity in UPIA. CONCLUSIONS: Ten recommendations on how to investigate and follow-up UPIA in the clinical setting were developed. They are evidence-based and supported by a large panel of rheumatologists, thus enhancing their validity...

  1. In Vivo and In Vitro Dynamics of Undifferentiated Embryonic Cell Transcription Factor 1

    Directory of Open Access Journals (Sweden)

    Christina Galonska

    2014-03-01

    Full Text Available Pluripotent stem cells retain the ability to differentiate into the three germ layers and germline. As a result, there is a major interest in characterizing regulators that establish and maintain pluripotency. The network of transcription factors continues to expand in complexity, and one factor, undifferentiated embryonic cell transcription factor 1 (UTF1, has recently moved more into the limelight. To facilitate the study of UTF1, we report the generation and characterization of two reporter lines that enable efficient tracking, mapping, and purification of endogenous UTF1. In particular, we include a built-in biotinylation system in our targeted locus that allows efficient and reliable pulldown. We also use this reporter to show the dynamic regulation of Utf1 in distinct stem cell conditions and demonstrate its utility for reprogramming studies. The multipurpose design of the reporter lines enables many directions of future study and should lead to a better understanding of UTF1’s diverse roles.

  2. COMPARATIVE ANALYSIS OF LONG-TERM RESULTS OF SURGICAL AND COMBINATION THERAPY FOR DIFFERENTIATED ADENOCARCINOMA AND UNDIFFERENTIATED GASTRIC CANCER

    Directory of Open Access Journals (Sweden)

    A. G. Davtyan

    2013-01-01

    Full Text Available The comparative analysis of long-term results of surgical and combined modality treatment for differentiated adenocarcinoma and undifferentiated gastric carcinoma (UGC has been presented. Treatment outcomes of patients with differentiated adenocarcinoma were shownto be significantly superior to those of patients with UGC (р=0,001. Intensive preoperative radiation therapy at a total dose of 20–27 Gy resulted in a significant improvement of treatment outcomes in patients with UGC, showing no any improvement of treatment outcomes in patients with differentiated adenocarcinoma. The benefits of combination treatment for patients with UGC were observed in cases with tumors not spreading through the serosa (рТ1–3 and with no evidence of regional lymph nodes involvement (N0.

  3. Ring complexes and related rocks in Africa

    Science.gov (United States)

    Vail, J. R.

    Over 625 igneous complexes throughout Africa and Arabia have been selected and classified on the basis of petrographic association and chronology into six broad age groups forming 29 provinces. The groups range from Mid-Proterozoic to Tertiary and include gabbro, granite, syenite, foid syenite and carbonatite plutonic rocks, the majority in the form of ring-dykes, cone-sheets, plugs, circular intrusions, and their associated extrusive phases. Pan-African late or post-orogenic complexes (720-490 Ma) are common in the Arabian-Nubian and Tuareg shields of north Africa originating from subduction zone derived magmatism. Anorogenic complexes in Egypt, NE and central Sudan, Niger, Nigeria, Cameroon, Zaïre-Burundi, Malawi, Mozambique, Zimbabwe, Namibia and Angola span 550 to 50 Ma and are dominantly alkali granites and foid syenites. Many groups occur as en-echelon bands within linear arrays, and show migrating centres of intrusion in variable directions. In W. Africa there was a progressive shift of emplacement southwards during early Ordovician to Mid-Cretaceous times. Distribution patterns suggest thatdeep seated features, such as shear zones associated with lithospheric plate movements,controlled melting, and the resultant location of the complexes. Economic mineralization is not widespread in the rocks of the African ring complexes and is mainly restricted to small deposits of Sn, W, F, U and Nb.

  4. Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status

    Directory of Open Access Journals (Sweden)

    de Carvalho Marcelo

    2011-03-01

    Full Text Available Abstract Background In the bone marrow, hematopietic and mesenchymal stem cells form a unique niche in which the oxygen tension is low. Hypoxia may have a role in maintaining stem cell fate, self renewal and multipotency. However, whereas most studies addressed the effect of transient in vitro exposure of MSC to hypoxia, permanent culture under hypoxia should reflect the better physiological conditions. Results Morphologic studies, differentiation and transcriptional profiling experiments were performed on MSC cultured in normoxia (21% O2 versus hypoxia (5% O2 for up to passage 2. Cells at passage 0 and at passage 2 were compared, and those at passage 0 in hypoxia generated fewer and smaller colonies than in normoxia. In parallel, MSC displayed (>4 fold inhibition of genes involved in DNA metabolism, cell cycle progression and chromosome cohesion whereas transcripts involved in adhesion and metabolism (CD93, ESAM, VWF, PLVAP, ANGPT2, LEP, TCF1 were stimulated. Compared to normoxic cells, hypoxic cells were morphologically undifferentiated and contained less mitochondrias. After this lag phase, cells at passage 2 in hypoxia outgrew the cells cultured in normoxia and displayed an enhanced expression of genes (4-60 fold involved in extracellular matrix assembly (SMOC2, neural and muscle development (NOG, GPR56, SNTG2, LAMA and epithelial development (DMKN. This group described herein for the first time was assigned by the Gene Ontology program to "plasticity". Conclusion The duration of hypoxemia is a critical parameter in the differentiation capacity of MSC. Even in growth promoting conditions, hypoxia enhanced a genetic program that maintained the cells undifferentiated and multipotent. This condition may better reflect the in vivo gene signature of MSC, with potential implications in regenerative medicine.

  5. Cytokine and immunoglobulin production by PWM-stimulated peripheral and tumor-infiltrating lymphocytes of undifferentiated nasopharyngeal carcinoma (NPC patients

    Directory of Open Access Journals (Sweden)

    Bouzouita Kamel

    2004-09-01

    Full Text Available Abstract Background Undifferentiated Nasopharyngeal Carcinoma (NPC patients show a characteristic pattern of antibody responses to the Epstein-Barr virus (EBV which is regularly associated with this tumor. However, no EBV-specific cytotoxic activity is detectable by the standard chromium-release assay at both peripheral and intratumoral levels. The mechanisms underlying this discrepancy between the humoral and cellular immune responses in NPC are still unknown, but might be related to an imbalance in immunoregulatory interleukin production. In this report, we investigated the ability of peripheral (PBL and tumor- infiltrating (TIL lymphocytes of undifferentiated NPC patients to produce in vitro three interleukins (IL-2, IL-6, IL-10 and three immunoglobulin isotypes (IgM, IgG, IgA. Methods Lymphocytes from 17 patients and 17 controls were cultured in the presence of Pokeweed mitogen (PWM for 12 days and their culture supernatants were tested for interleukins and immunoglobulins by specific enzyme-linked immunosorbent assays (ELISA. Data were analysed using Student's t-test and probability values below 5% were considered significant. Results The data obtained indicated that TIL of NPC patients produced significantly more IL-2 (p = 0,0002, IL-10 (p = 0,020, IgM (p= 0,0003 and IgG (p Conclusion Taken together, our data reinforce the possibility of an imbalance in immunoregulatory interleukin production in NPC patients. An increased ability to produce cytokines such as IL-10 may underlie the discrepancy between humoral and cellular immune responses characteristic of NPC.

  6. Geologic and biostratigraphic framework of the non-marine Cretaceous-Tertiary boundary interval in western North America

    Science.gov (United States)

    Nichols, D.J.

    1990-01-01

    Palynologically defined Cretaceous-Tertiary boundary sites in nonmarine rocks in western North America exhibit similar characteristics. All are marked by abrupt disappearance of the regional uppermost Cretaceous palynoflora at the level of an iridium anomaly; most also yeild shock-metamorphosed minerals. All are in coal-bearing, fluvial or paludal depositional settings, although the boundary horizon may be below, within, above, or at some stratigraphic distance from coal seams. At many sites the lowermost Tertiary beds contain assemblages overwhelmed by fern spores that, together with extinctions of some groups of angiosperms, are taken as evidence of regional devastation of terrestrial plant communities and subsequent recolonization by pioneer species. ?? 1990.

  7. Northeast Church Rock Mine

    Science.gov (United States)

    Northeast Church Rock Mine, a former uranium mine 17 miles northeast of Gallup, NM in the Pinedale Chapter of the Navajo Nation. EPA is working with NNEPA to oversee cleanup work by United Nuclear Corporation, a company owned by General Electric (GE).

  8. Rock-hard coatings

    OpenAIRE

    Muller, M.

    2007-01-01

    Aircraft jet engines have to be able to withstand infernal conditions. Extreme heat and bitter cold tax coatings to the limit. Materials expert Dr Ir. Wim Sloof fits atoms together to develop rock-hard coatings. The latest invention in this field is known as ceramic matrix composites. Sloof has signed an agreement with a number of parties to investigate this material further.

  9. Rock-hard coatings

    NARCIS (Netherlands)

    Muller, M.

    2007-01-01

    Aircraft jet engines have to be able to withstand infernal conditions. Extreme heat and bitter cold tax coatings to the limit. Materials expert Dr Ir. Wim Sloof fits atoms together to develop rock-hard coatings. The latest invention in this field is known as ceramic matrix composites. Sloof has

  10. Fluids in metamorphic rocks

    NARCIS (Netherlands)

    Touret, J.L.R.

    2001-01-01

    Basic principles for the study of fluid inclusions in metamorphic rocks are reviewed and illustrated. A major problem relates to the number of inclusions, possibly formed on a wide range of P-T conditions, having also suffered, in most cases, extensive changes after initial trapping. The

  11. IL10 GGC haplotype is positively and HLA-DQA1*05-DQB1*02 is negatively associated with radiographic progression in undifferentiated arthritis

    NARCIS (Netherlands)

    Ursum, J.; van der Weijden, M.A.C.; van Schaardenburg, D.; Prins, A.P.; Dijkmans, B.A.C.; Twisk, J.W.R.; Crusius, J.B.A.; van der Horst-Bruinsma, I.E.

    2010-01-01

    Objective. In rheumatoid arthritis (RA), many genetic markers, such as the shared-epitope (SE) alleles, are described in association with radiographic progression, but limited data are available on undifferentiated arthritis (UA). We investigated whether single-nucleotide polymorphisms (SNP) and

  12. Tumor-targeting Salmonella typhimurium A1-R is a highly effective general therapeutic for undifferentiated soft tissue sarcoma patient-derived orthotopic xenograft nude-mouse models.

    Science.gov (United States)

    Igarashi, Kentaro; Kawaguchi, Kei; Kiyuna, Tasuku; Miyake, Kentaro; Miyake, Masuyo; Singh, Arun S; Eckardt, Mark A; Nelson, Scott D; Russell, Tara A; Dry, Sarah M; Li, Yunfeng; Yamamoto, Norio; Hayashi, Katsuhiro; Kimura, Hiroaki; Miwa, Shinji; Tsuchiya, Hiroyuki; Singh, Shree Ram; Eilber, Fritz C; Hoffman, Robert M

    2018-03-18

    Undifferentiated soft tissue sarcoma (USTS) is a recalcitrant and heterogeneous subgroup of soft tissue sarcoma with high risk of metastasis and recurrence. Due to heterogeneity of USTS, there is no reliably effective first-line therapy. We have generated tumor-targeting Salmonella typhimurium A1-R (S. typhimurium A1-R), which previously showed strong efficacy on single patient-derived orthotopic xenograft (PDOX) models of Ewing's sarcoma and follicular dendritic cell sarcoma. In the present study, tumor resected from 4 patients with a biopsy-proven USTS (2 undifferentiated pleomorphic sarcoma [UPS], 1 undifferentiated sarcoma not otherwise specified [NOS] and 1 undifferentiated spindle cell sarcoma [USS]) were grown orthotopically in the biceps femoris muscle of mice to establish PDOX models. One USS model and one UPS model were doxorubicin (DOX) resistant. One UPS and the NOS model were partially sensitive to DOX. DOX is first-line therapy for these diseases. S. typhimurium A1-R arrested tumor growth all 4 models. In addition to arresting tumor growth in each case, S. typhimurium A1-R was significantly more efficacious than DOX in each case, thereby surpassing first-line therapy. These results suggest that S. typhimurium A1-R can be a general therapeutic for USTS and possibly sarcoma in general. Published by Elsevier Inc.

  13. Soil/Rock Properties Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — Soil/Rock Properties LaboratoryLocation: Spokane SiteThe Soil/Rock Properties Laboratory is contained in the soils bay, a 4,700 sq. ft. facility that provides space...

  14. Anomalies within the system - Rochechouart target rock meteorite

    Science.gov (United States)

    Lambert, P.

    1982-01-01

    Contaminated impact crater formations are pertinent to the study of meteoritic contamination at the Cretaceous-Tertiary boundary and other Ir-enriched layers. Target mixing considerations and volumetric estimates of Rochechouart breccias are presently combined with the geochemistry of both major and siderophile trace elements, to evaluate how the chemistry of the preserved target rock-projectile mixture evolved since deposition. Over 99 percent of the mass of extraterrestrial Ir and Os in preserved formations at Rochechouart is located in suevite-like breccias and impact melts. Hydrothermal alteration and/or weathering are the most likely processes to explain both major and trace element redistribution in Rochechouart formations.

  15. Uranium in alkaline rocks

    International Nuclear Information System (INIS)

    Murphy, M.; Wollenberg, H.; Strisower, B.; Bowman, H.; Flexser, S.; Carmichael, I.

    1978-04-01

    Geologic and geochemical criteria were developed for the occurrence of economic uranium deposits in alkaline igneous rocks. A literature search, a limited chemical analytical program, and visits to three prominent alkaline-rock localities (Ilimaussaq, Greenland; Pocos de Caldas, Brazil; and Powderhorn, Colorado) were made to establish criteria to determine if a site had some uranium resource potential. From the literature, four alkaline-intrusive occurrences of differing character were identified as type-localities for uranium mineralization, and the important aspects of these localities were described. These characteristics were used to categorize and evaluate U.S. occurrences. The literature search disclosed 69 U.S. sites, encompassing nepheline syenite, alkaline granite, and carbonatite. It was possible to compare two-thirds of these sites to the type localities. A ranking system identified ten of the sites as most likely to have uranium resource potential

  16. Uranium in alkaline rocks

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, M.; Wollenberg, H.; Strisower, B.; Bowman, H.; Flexser, S.; Carmichael, I.

    1978-04-01

    Geologic and geochemical criteria were developed for the occurrence of economic uranium deposits in alkaline igneous rocks. A literature search, a limited chemical analytical program, and visits to three prominent alkaline-rock localities (Ilimaussaq, Greenland; Pocos de Caldas, Brazil; and Powderhorn, Colorado) were made to establish criteria to determine if a site had some uranium resource potential. From the literature, four alkaline-intrusive occurrences of differing character were identified as type-localities for uranium mineralization, and the important aspects of these localities were described. These characteristics were used to categorize and evaluate U.S. occurrences. The literature search disclosed 69 U.S. sites, encompassing nepheline syenite, alkaline granite, and carbonatite. It was possible to compare two-thirds of these sites to the type localities. A ranking system identified ten of the sites as most likely to have uranium resource potential.

  17. Rock and mineral magnetism

    CERN Document Server

    O’Reilly, W

    1984-01-01

    The past two decades have witnessed a revolution in the earth sciences. The quantitative, instrument-based measurements and physical models of. geophysics, together with advances in technology, have radically transformed the way in which the Earth, and especially its crust, is described. The study of the magnetism of the rocks of the Earth's crust has played a major part in this transformation. Rocks, or more specifically their constituent magnetic minerals, can be regarded as a measuring instrument provided by nature, which can be employed in the service of the earth sciences. Thus magnetic minerals are a recording magnetometer; a goniometer or protractor, recording the directions of flows, fields and forces; a clock; a recording thermometer; a position recorder; astrain gauge; an instrument for geo­ logical surveying; a tracer in climatology and hydrology; a tool in petrology. No instrument is linear, or free from noise and systematic errors, and the performance of nature's instrument must be assessed and ...

  18. Limados : Rock peruano

    OpenAIRE

    García Morete, Ramiro

    2013-01-01

    Incentivado por la corriente nuevaolera que llegaba de México, fue señalado por especialistas como pionero del punk. Aunque el plan, era tocar con lo que hubiera. Un recodo ínfimo de un período breve pero sorprendentemente poderoso, los 60 en un país que hizo del rock una expresión propia de su cultura. Facultad de Periodismo y Comunicación Social

  19. Deformations of fractured rock

    International Nuclear Information System (INIS)

    Stephansson, O.

    1977-09-01

    Results of the DBM and FEM analysis in this study indicate that a suitable rock mass for repository of radioactive waste should be moderately jointed (about 1 joint/m 2 ) and surrounded by shear zones of the first order. This allowes for a gentle and flexible deformation under tectonic stresses and prevent the development of large cross-cutting failures in the repository area. (author)

  20. Rock in Rio: forever young

    Directory of Open Access Journals (Sweden)

    Ricardo Ferreira Freitas

    2014-12-01

    Full Text Available The purpose of this article is to discuss the role of Rock in Rio: The Musical, as herald of megafestival Rock in Rio. Driven by the success that musicals have reached in Brazil, we believe that the design of this spectacle of music, dance and staging renews the brand of the rock festival, once it adds the force of young and healthy bodies to its concept. Moreover, the musical provides Rock in Rio with some distance from the controversal trilogy of sex, drugs and rock and roll, a strong mark of past festivals around the world. Thus, the musical expands the possibilities of growth for the brand.

  1. Hydrological characteristics of Japanese rock

    International Nuclear Information System (INIS)

    Ijiri, Yuji; Sawada, Atsushi; Akahori, Kuniaki

    1999-11-01

    It is crucial to evaluate the hydrogeological characteristics of rock in Japan in order to assess the performance of geosphere. This report summarizes the hydrogeological characteristics of various rock types obtained from broad literature surveys and the fields experiments at the Kamaishi mine in northern Japan and at the Tono mine in central Japan. It is found that the hydraulic conductivity of rock mass ranges from 10 -9 m/s to 10 -8 m/s, whereas the hydraulic conductivity of fault zone ranges from 10 -9 m/s to 10 -3 m/s. It is also found that the hydraulic conductivity tends to decrease with depth. Therefore, the hydraulic conductivity of rock mass at the depth of a repository will be smaller than above values. From the investigations at outcrops and galleries throughout the country, fractures are observed as potential pathways in all rock types. All kinds of crystalline rocks and pre-Neogene sedimentary rocks are classified as fractured media where fracture flow is dominant. Among these rocks, granitic rock is considered the archetype fractured media. On the other hand, andesite, tuff and Neogene sedimentary rocks are considered as intermediate between fractured media and porous media where flow in fractures as well as in rock matrix are significant. (author)

  2. Development of artificial soft rock

    International Nuclear Information System (INIS)

    Kishi, Kiyoshi

    1995-01-01

    When foundation base rocks are deeper than the level of installing structures or there exist weathered rocks and crushed rocks in a part of base rocks, often sound artificial base rocks are made by substituting the part with concrete. But in the construction of Kashiwazaki Kariwa Nuclear Power Station of Tokyo Electric Power Co., Inc., the foundation base rocks consist of mudstone, and the stiffness of concrete is large as compared with the surrounding base rocks. As the quality of the substituting material, the nearly same stiffness as that of the surrounding soft rocks and long term stability are suitable, and the excellent workability and economical efficiency are required, therefore, artificial soft rocks were developed. As the substituting material, the soil mortar that can obtain the physical property values in stable form, which are similar to those of Nishiyama mudstone, was selected. The mechanism of its hardening and the long term stability, and the manufacturing plant are reported. As for its application to the base rocks of Kashiwazaki Kariwa Nuclear Power Station, the verification test at the site and the application to the base rocks for No. 7 plant reactor building and other places are described. (K.I.)

  3. Radioguided parathyroidectomy for tertiary hyperparathyroidism.

    Science.gov (United States)

    Somnay, Yash R; Weinlander, Eric; Alfhefdi, Amal; Schneider, David; Sippel, Rebecca S; Chen, Herbert

    2015-05-15

    Tertiary hyperparathyroidism (3HPT) is defined as the persistent hyperproduction of parathyroid hormone and resulting hypercalcemia after renal transplantation. Here, we examine the utility of radioguided parathyroidectomy (RGP) in patients with 3HPT. We reviewed a prospective surgery database containing 80 3HPT patients who underwent RGP from January 2001-July 2014 at our institution. We evaluated patient demographics, operative management, radioguided neoprobe utilization, and operative outcomes. Data are reported as mean ± standard error of the mean. The mean age of the patients was 52 ± 1 y, and 46% were male. A total of 69 patients had hyperplasia and received subtotal parathyroidectomy, whereas 5 patients had double adenomas and 6 patients had single adenomas. The average calcium level among 3HPT patients was 10.8 ± 0.1 mg/dL preoperatively and 8.7 ± 0.1 mg/dL postoperatively. In vivo radioguided counts normalized to background counts averaged 145 ± 4%, whereas ex vivo counts normalized to background counts averaged 69 ± 5%. All but one ex vivo count was >20%. Ectopically located glands were successfully localized in 38 patients using the gamma probe. Ex vivo percentage did not correlate with parathyroid gland weight, preoperative parathyroid hormone, or preoperative calcium. Our radioguided approach achieved normocalcemia in 96% of 3HPT patients undergoing RGP; two patients developed recurrent disease. In this series, all enlarged parathyroid glands were localized and resected using the gamma probe. Thus, RGP reliably localizes adenomatous, hyperplastic, and ectopically located glands in patients with 3HPT, resulting in high cure rate after resection. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Geophysical, geochemical, mineralogical, and enivronmental data for rock samples collected in a mineralized volcanic environment, upper Animas River watershed, Colorado

    Science.gov (United States)

    McCafferty, A.E.; Horton, R.J.; Stanton, M.R.; McDougal, R.R.; Fey, D.L.

    2011-01-01

    This report provides analyses of 90 rock samples collected in the upper Animas River watershed near Silverton, Colo., from 2001 to 2007. The samples are analyzed for geophysical, geochemical, mineralogical, and environmental rock properties of acid neutralizing capacity and net acid production. The database is derived from both published (n=68) and unpublished (n=32) data. New for all samples are geophysical measurements of electrical resistivity, density, and porosity. Rock samples were acquired from 12 geologic units that include key Tertiary volcanic and plutonic lithologies, all with varying degrees of alteration.

  5. Rock Pore Structure as Main Reason of Rock Deterioration

    Science.gov (United States)

    Ondrášik, Martin; Kopecký, Miloslav

    2014-03-01

    Crashed or dimensional rocks have been used as natural construction material, decoration stone or as material for artistic sculptures. Especially old historical towns not only in Slovakia have had experiences with use of stones for construction purposes for centuries. The whole buildings were made from dimensional stone, like sandstone, limestone or rhyolite. Pavements were made especially from basalt, andesite, rhyolite or granite. Also the most common modern construction material - concrete includes large amounts of crashed rock, especially limestone, dolostone and andesite. However, rock as any other material if exposed to exogenous processes starts to deteriorate. Especially mechanical weathering can be very intensive if rock with unsuitable rock properties is used. For long it had been believed that repeated freezing and thawing in relation to high absorption is the main reason of the rock deterioration. In Slovakia for many years the high water absorption was set as exclusion criterion for use of rocks and stones in building industry. Only after 1989 the absorption was accepted as merely informational rock property and not exclusion. The reason of the change was not the understanding of the relationship between the porosity and rock deterioration, but more or less good experiences with some high porous rocks used in constructions exposed to severe weather conditions and proving a lack of relationship between rock freeze-thaw resistivity and water absorption. Results of the recent worldwide research suggest that understanding a resistivity of rocks against deterioration is hidden not in the absorption but in the structure of rock pores in relation to thermodynamic properties of pore water and tensile strength of rocks and rock minerals. Also this article presents some results of research on rock deterioration and pore structure performed on 88 rock samples. The results divide the rocks tested into two groups - group N in which the pore water does not freeze

  6. Tertiary Logistics in the Focus of All Logistics

    OpenAIRE

    Ratko Zelenika; Mirjana Grèiæ; Helga Pavliæ Skender

    2008-01-01

    Trade logistics, traffic logistics, transport logistics and warehouse logistics are just some of the tertiary logistics which enables production processes of all economic sector products and services. Tertiary logistics representing the tertiary economic sector is the most sofisticated and the most important logistics due to the characteristics of the tertiary sector as a service sector that promotes business conditions in all economic sectors. Accordingly, tertiary logistics has a crucial ro...

  7. Upper Cretaceous source rocks of northern and northwestern South America

    Energy Technology Data Exchange (ETDEWEB)

    Talukdar, S.; Gallango, O.; Cassani, F.; Vallejos, C.

    1989-03-01

    Organic carbon-rich, laminated, calcareous shales and limestones of Cenomanian to Campanian age are widespread in the polyhistory basins of Venezuela, Colombia, and Trinidad and are identified as the most important oil-generating source rocks in these basins. Available data on sedimentological, geochemical, and organic petrographic characteristics demonstrate that these source rocks are characterized by predominantly marine organic matter deposited in anoxic to near-anoxic marine environments. Marine transgressions due to eustatic sea level rise, with consequent flooding of available shelves of the northern and northwestern passive margin of the Cretaceous South American continent and resulting upwelling conditions, appears to be the key geologic control for the deposition of these laterally extensive source rocks. Significant vertical variations in geochemical properties are observed. These variations were caused by temporal changes in the influx of terrestrial organic matter and/or alternations of relatively oxic and anoxic conditions. Regional variations in organic carbon content, organic matter type, and oil potential broadly reflect the paleogeographic setting of the Cretaceous continental margin. The regionally extensive oil-prone source rocks became largely mature for hydrocarbon generation during the Tertiary, consequent to the development of the individual polyhistory basins. Rock-Eval pyrolysis data from several samples and results from hydrous pyrolysis experiments on some selected immature samples from the Venezuelan basins are used to define the oil-generating capacity, and kinetic parameters obtained from Rock-Eval experiments on the same samples are considered to outline the oil generation under the geological heating rates encountered in the sedimentary basins.

  8. Consensus Guidelines for Practical Competencies in Anatomic Pathology and Laboratory Medicine for the Undifferentiated Graduating Medical Student.

    Science.gov (United States)

    Magid, Margret S; Shah, Darshana T; Cambor, Carolyn L; Conran, Richard M; Lin, Amy Y; Peerschke, Ellinor I B; Pessin, Melissa S; Harris, Ilene B

    2015-01-01

    The practice of pathology is not generally addressed in the undergraduate medical school curriculum. It is desirable to develop practical pathology competencies in the fields of anatomic pathology and laboratory medicine for every graduating medical student to facilitate (1) instruction in effective utilization of these services for optimal patient care, (2) recognition of the role of pathologists and laboratory scientists as consultants, and (3) exposure to the field of pathology as a possible career choice. A national committee was formed, including experts in anatomic pathology and/or laboratory medicine and in medical education. Suggested practical pathology competencies were developed in 9 subspecialty domains based on literature review and committee deliberations. The competencies were distributed in the form of a survey in late 2012 through the first half of 2013 to the medical education community for feedback, which was subjected to quantitative and qualitative analysis. An approval rate of ≥80% constituted consensus for adoption of a competency, with additional inclusions/modifications considered following committee review of comments. The survey included 79 proposed competencies. There were 265 respondents, the majority being pathologists. Seventy-two percent (57 of 79) of the competencies were approved by ≥80% of respondents. Numerous comments (N = 503) provided a robust resource for qualitative analysis. Following committee review, 71 competencies (including 27 modified and 3 new competencies) were considered to be essential for undifferentiated graduating medical students. Guidelines for practical pathology competencies have been developed, with the hope that they will be implemented in undergraduate medical school curricula.

  9. CD10 positive recurrent undifferentiated mammary sarcoma in a young female: a rare case report with brief review of literature

    Directory of Open Access Journals (Sweden)

    Kachnar Varma

    2015-06-01

    Full Text Available Undifferentiated mammary sarcoma is extremely rare and the diagnosis is made only after exclusion of metaplastic carcinomas and malignant phyllodes tumor. Mammary sarcomas mostly display specified entities like liposarcomas or angiosarcomas. A 18-year-old female presented in 2010 with a right breast lump for which lumpectomy was done and on histopathological examination benign phyllodes tumor was diagnosed. In 2011, there was a recurrence at site of excised margin and on fine needle aspiration (FNA the diagnosis of benign breast disease was made; a small biopsy was received for which diagnosis of myoepithelial lesion was given. Then, the whole mass was excised, but histopathological examination report could not be followed up. In 2013, she again presented with a mass arising from the previously excised margin; on FNA, it was diagnosed as malignant sarcomatous lesion. Microscopy showed spindle shaped cells in diffuse and fascicular pattern with plump ovoid nuclei; coarse chromatin and eosinophilic cytoplasm were seen. Few round to ovoid cells with eccentric nuclei and showing bi- or multi-nucleation were present. Large area of necrosis and hemorrhage was present, too. No breast glands were found. Later on, diagnosis was confirmed on immunohistochemical examination. The case was considered worth due to the young age of the patient and lack of differentiation of the lesion in any specific type of sarcoma and CD10 positivity.

  10. Retroperitoneal undifferentiated pleomorphic sarcoma having microsatellite instability associated with Muir-Torre syndrome: case report and review of literature.

    Science.gov (United States)

    Lee, Nathan; Luthra, Rajyalakshmi; Lopez-Terrada, Dolores; Wang, Wei-Lien; Lazar, Alexander J

    2013-08-01

    Muir-Torre syndrome represents a rare autosomal dominant familial cancer predisposition disorder defined by the occurrence of cutaneous sebaceous tumors and an internal malignancy, most commonly gastrointestinal carcinoma. Most examples of hereditary non-polyposis cancer syndrome (Lynch syndrome), including the Muir-Torre syndrome, are associated with microsatellite instability (MSI) and germline mutations in mismatch repair genes-most commonly MLH1 or MSH2. We present a 58-year-old man with Muir-Torre syndrome and a large retroperitoneal mass (14.3 cm in greatest dimension) encompassing the left adrenal gland. Sections showed a cellular malignant tumor composed of spindle cells with a high mitotic index and lacking morphologic evidence of adipocytic differentiation. It was weakly reactive for smooth muscle actin (SMA) and negative for desmin, CD117, CD31, CD34, S100 protein and pan-cytokeratin. Further immunohistochemical analysis revealed intact expression of MLH1 but loss of MSH2 in tumor nuclei. Compared to non-neoplastic tissue, the tumor showed MSI in five of seven dinucleotide markers. Fluorescence in situ hybridization (FISH) failed to reveal 12q15 amplification, effectively excluding dedifferentiated liposarcoma as a diagnostic consideration. This is a rare case of a patient with Muir-Torre syndrome who developed a related high-grade undifferentiated pleomorphic sarcoma as the associated internal malignancy. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  11. Application of the boron neutron capture therapy to undifferentiated thyroid cancer using two boron compounds (BPA and BOPP)

    International Nuclear Information System (INIS)

    Viaggi, Mabel; Dagrosa, Maria A.; Juvenal, Guillermo J.; Pisarev, Mario A.; Longhino, Juan M.; Blaumann, Hernan R.; Calzetta Larrieu, Osvaldo A.; Kahl, Stephen B.

    2004-01-01

    We have shown the selective uptake of boronophenylalanine (BPA) by undifferentiated thyroid cancer (UTC) human cell line ARO, both in vitro and in vivo. Moreover, a 50% histologic cure of mice bearing the tumor was observed when the complete boron neutron capture therapy was applied. More recently we have analyzed the biodistribution of BOPP (tetrakis-carborane carboxylate ester of 2,4-bis-(ba-dihydroxyethyl)-deutero-porphyrin IX) and showed that when BOPP was injected 5 days before BPA, and the animals were sacrificed 60 min after the ip injection of BPA, a significant increase in boron uptake by the tumor was found (38-45ppm with both compounds Vs. 20 ppm with BPA alone). Five days post the ip BOPP injection and 1 hr after BPA, the ratios were: tumor/blood 3,75; tumor /distal skin 2. Other important ratios were tumor/thyroid 6,65 and tumor/lung 3,8. The present studies were performed in mice transplanted with ARO cells and injected with BOPP and BPA. Only in mice treated with the neutron beam and injected with the boronated compounds we observed a 100% control of tumor growth. Two groups of mice received different total absorbed doses: 3.00 and 6.01 Gy, but no further improvement in the outcome was found compared to the previous results using BPA alone (4.3 Gy). (author)

  12. Immunohistochemical expression of estrogens and progesterone receptors in carcinoma ex pleomorphic adenoma-undifferentiated and adenocarcinoma types.

    Science.gov (United States)

    Tarakji, Bassel; Nassani, Mohammad Z; Sloan, Philip

    2010-05-01

    Cancer of the salivary gland is one of the common cancers in the head and the neck regions. This type of cancer develops in the minor and the major salivary glands, and it sometimes metastasizes to other organs, particularly the lung. Morphologic mimicry and similarity in the expression of steroid hormone receptors between salivary gland tumours and breast tumours are well-known phenomena and are occasionally debated in the field of surgical pathology. The expression of sex hormone receptors in some tumours suggests a role for these receptors in tumor pathogenesis and therapy. Previous studies of the expression of estrogens and progesterone receptors in salivary gland tumours have reported conflicting results. Our study aimed to characterize alteration in the immunohistochemical expression of oestrogens receptor and progesterone receptor in the tumour cells of carcinoma arising in pleomorphic adenoma. 27 cases of carcinoma arising in pleomorphic adenoma (undifferentiated and adenocarcinoma types) were examined. The results showed that 27 (100 %) of 27 cases had negative nuclear staining for either oestrogens or progesterone receptors. Our data suggest that carcinomas arising in pleomorphic adenoma were not dependent on endocrine function.

  13. Hemorrhagic fever with renal syndrome and Crimean-Congo hemorrhagic fever as causes of acute undifferentiated febrile illness in Bulgaria.

    Science.gov (United States)

    Christova, Iva; Younan, Rasha; Taseva, Evgenia; Gladnishka, Teodora; Trifonova, Iva; Ivanova, Vladislava; Spik, Kristin; Schmaljohn, Connie; Mohareb, Emad

    2013-03-01

    Hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF) are the 2 widespread viral hemorrhagic fevers occurring in Europe. HFRS is distributed throughout Europe, and CCHF has been reported mainly on the Balkan Peninsula and Russia. Both hemorrhagic fevers are endemic in Bulgaria. We investigated to what extent acute undifferentiated febrile illness in Bulgaria could be due to hantaviruses or to CCHF virus. Using enzyme-linked immunosorbent assays (ELISAs), we tested serum samples from 527 patients with acute febrile illness for antibodies against hantaviruses and CCHF virus. Immunoglobulin M (IgM) antibodies against hantaviruses were detected in 15 (2.8%) of the patients. Of the 15 hantavirus-positive patients, 8 (1.5%) were positive for Dobrava virus (DOBV), 5 (0.9%) were positive for Puumala virus (PUUV), and the remaining 2 were positive for both hantaviruses. A plaque reduction neutralization test (PRNT) confirmed 4 of the 10 DOBV-positive samples. PRNT was negative for all PUUV-positive samples. Serologic evidence of recent CCHF virus infection was found in 13 (2.5%) of the patients. Interestingly, HFRS and CCHF were not only detected in well-known endemic areas of Bulgaria but also in nonendemic regions. Our results suggested that in endemic countries, CCHF and/or HFRS might appear as a nonspecific febrile illness in a certain proportion of patients. Physicians must be aware of possible viral hemorrhagic fever cases, even if hemorrhages or renal impairment are not manifested.

  14. Atlantoaxial subluxation as an early manifestation in an adolescent with undifferentiated spondyloarthritis: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Jea Andrew

    2011-07-01

    Full Text Available Abstract Introduction Atlantoaxial instability has been described as a manifestation of ankylosing spondylitis (juvenile and adult onset, reactive arthritis, juvenile idiopathic arthritis, and rheumatoid arthritis; however, it has rarely been reported as an early manifestation of these disorders. We present this case report to increase awareness of the condition in the hope that earlier recognition of this disease may prevent further serious injury. Case presentation We report the case of a 17-year-old Hispanic adolescent woman who was initially diagnosed with undifferentiated spondyloarthritis due to peripheral arthritis, enthesitis, a positive human leukocyte antigen B27 result, and inflammatory spinal pain lasting two months. Our patient experienced persistent and worsening occipitocervical pain and signs of myelopathy three months after diagnosis; consequently, we found atlantoaxial instability along with cervical spine bone erosion and pannus formation. She was treated surgically with a C1-2 posterior instrumented fusion and at six weeks post-operatively was started on tumor necrosis factor α blockade. Her occipitocervical symptoms subsided following surgery and initiation of immunomodulation. Conclusions Our report serves to emphasize to pediatric and adult general practitioners, pediatricians, internists, family physicians, pediatric and adult rheumatologists and spine surgeons that atlantoaxial subluxation may be an early manifestation of spondyloarthritis, and that the condition is treatable by surgical intervention and immunomodulation.

  15. Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.

    Science.gov (United States)

    Magnusson, Mattias; Sierra, Maria I; Sasidharan, Rajkumar; Prashad, Sacha L; Romero, Melissa; Saarikoski, Pamela; Van Handel, Ben; Huang, Andy; Li, Xinmin; Mikkola, Hanna K A

    2013-01-01

    Lack of HLA-matched hematopoietic stem cells (HSC) limits the number of patients with life-threatening blood disorders that can be treated by HSC transplantation. So far, insufficient understanding of the regulatory mechanisms governing human HSC has precluded the development of effective protocols for culturing HSC for therapeutic use and molecular studies. We defined a culture system using OP9M2 mesenchymal stem cell (MSC) stroma that protects human hematopoietic stem/progenitor cells (HSPC) from differentiation and apoptosis. In addition, it facilitates a dramatic expansion of multipotent progenitors that retain the immunophenotype (CD34+CD38-CD90+) characteristic of human HSPC and proliferative potential over several weeks in culture. In contrast, transplantable HSC could be maintained, but not significantly expanded, during 2-week culture. Temporal analysis of the transcriptome of the ex vivo expanded CD34+CD38-CD90+ cells documented remarkable stability of most transcriptional regulators known to govern the undifferentiated HSC state. Nevertheless, it revealed dynamic fluctuations in transcriptional programs that associate with HSC behavior and may compromise HSC function, such as dysregulation of PBX1 regulated genetic networks. This culture system serves now as a platform for modeling human multilineage hematopoietic stem/progenitor cell hierarchy and studying the complex regulation of HSC identity and function required for successful ex vivo expansion of transplantable HSC.

  16. Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.

    Directory of Open Access Journals (Sweden)

    Mattias Magnusson

    Full Text Available Lack of HLA-matched hematopoietic stem cells (HSC limits the number of patients with life-threatening blood disorders that can be treated by HSC transplantation. So far, insufficient understanding of the regulatory mechanisms governing human HSC has precluded the development of effective protocols for culturing HSC for therapeutic use and molecular studies. We defined a culture system using OP9M2 mesenchymal stem cell (MSC stroma that protects human hematopoietic stem/progenitor cells (HSPC from differentiation and apoptosis. In addition, it facilitates a dramatic expansion of multipotent progenitors that retain the immunophenotype (CD34+CD38-CD90+ characteristic of human HSPC and proliferative potential over several weeks in culture. In contrast, transplantable HSC could be maintained, but not significantly expanded, during 2-week culture. Temporal analysis of the transcriptome of the ex vivo expanded CD34+CD38-CD90+ cells documented remarkable stability of most transcriptional regulators known to govern the undifferentiated HSC state. Nevertheless, it revealed dynamic fluctuations in transcriptional programs that associate with HSC behavior and may compromise HSC function, such as dysregulation of PBX1 regulated genetic networks. This culture system serves now as a platform for modeling human multilineage hematopoietic stem/progenitor cell hierarchy and studying the complex regulation of HSC identity and function required for successful ex vivo expansion of transplantable HSC.

  17. From stones to rocks

    Science.gov (United States)

    Mortier, Marie-Astrid; Jean-Leroux, Kathleen; Cirio, Raymond

    2013-04-01

    With the Aquila earthquake in 2009, earthquake prediction is more and more necessary nowadays, and people are waiting for even more accurate data. Earthquake accuracy has increased in recent times mainly thanks to the understanding of how oceanic expansion works and significant development of numerical seismic prediction models. Despite the improvements, the location and the magnitude can't be as accurate as citizen and authorities would like. The basis of anticipating earthquakes requires the understanding of: - The composition of the earth, - The structure of the earth, - The relations and movements between the different parts of the surface of the earth. In order to answer these questions, the Alps are an interesting field for students. This study combines natural curiosity about understanding the predictable part of natural hazard in geology and scientific skills on site: observing and drawing landscape, choosing and reading a representative core drilling, replacing the facts chronologically and considering the age, the length of time and the strength needed. This experience requires students to have an approach of time and space radically different than the one they can consider in a classroom. It also limits their imagination, in a positive way, because they realize that prediction is based on real data and some of former theories have become present paradigms thanks to geologists. On each location the analyzed data include landscape, core drilling and the relation established between them by students. The data is used by the students to understand the meaning, so that the history of the formation of the rocks tells by the rocks can be explained. Until this year, the CBGA's perspective regarding the study of the Alps ground allowed students to build the story of the creation and disappearance of the ocean, which was a concept required by French educational authorities. But not long ago, the authorities changed their scientific expectations. To meet the

  18. Comparative efficacy of tulathromycin versus a combination of florfenicol-oxytetracycline in the treatment of undifferentiated respiratory disease in large numbers of sheep

    OpenAIRE

    Mohsen Champour; Alinaghi Taghipour

    2015-01-01

    The objective of this study was to compare the efficacy of tulathromycin (TUL) with a combination of florfenicol (FFC) and long-acting oxytetracycline (LAOTC) in the treatment of naturally occurring undifferentiated respiratory diseases in large numbers of sheep. In this study, seven natural outbreaks of sheep pneumonia in Garmsar, Iran were considered. From these outbreaks, 400 sheep exhibiting the signs of respiratory diseases were selected, and the sheep were randomly divided into two equa...

  19. The CIPRUS study, a nurse-led psychological treatment for patients with undifferentiated somatoform disorder in primary care: study protocol for a randomised controlled trial

    OpenAIRE

    Sitnikova, Kate; Leone, Stephanie S.; Zonneveld, Lyonne N. L.; van Marwijk, Harm W. J.; Bosmans, Judith E.; van der Wouden, Johannes C.; van der Horst, Henri?tte E.

    2017-01-01

    Background Up to a third of patients presenting medically unexplained physical symptoms in primary care may have a somatoform disorder, of which undifferentiated somatoform disorder (USD) is the most common type. Psychological interventions can reduce symptoms associated with USD and improve functioning. Previous research has either been conducted in secondary care or interventions have been provided by general practitioners (GPs) or psychologists in primary care. As efficiency and cost-effec...

  20. A smart rock

    Science.gov (United States)

    Pressel, Phil

    2014-12-01

    This project was to design and build a protective weapon for a group of associations that believed in aliens and UFO's. They collected enough contributions from societies and individuals to be able to sponsor and totally fund the design, fabrication and testing of this equipment. The location of this facility is classified. It also eventually was redesigned by the Quartus Engineering Company for use at a major amusement park as a "shoot at targets facility." The challenge of this project was to design a "smart rock," namely an infrared bullet (the size of a gallon can of paint) that could be shot from the ground to intercept a UFO or any incoming suspicious item heading towards the earth. Some of the challenges to design this weapon were to feed cryogenic helium at 5 degrees Kelvin from an inair environment through a unique rotary coupling and air-vacuum seal while spinning the bullet at 1500 rpm and maintain its dynamic stability (wobble) about its spin axis to less than 10 micro-radians (2 arc seconds) while it operated in a vacuum. Precision optics monitored the dynamic motion of the "smart rock."

  1. Rock Properties Model

    International Nuclear Information System (INIS)

    Lum, C.

    2004-01-01

    The purpose of this model report is to document the Rock Properties Model version 3.1 with regard to input data, model methods, assumptions, uncertainties and limitations of model results, and qualification status of the model. The report also documents the differences between the current and previous versions and validation of the model. The rock properties model provides mean matrix and lithophysae porosity, and the cross-correlated mean bulk density as direct input to the ''Saturated Zone Flow and Transport Model Abstraction'', MDL-NBS-HS-000021, REV 02 (BSC 2004 [DIRS 170042]). The constraints, caveats, and limitations associated with this model are discussed in Section 6.6 and 8.2. Model validation accomplished by corroboration with data not cited as direct input is discussed in Section 7. The revision of this model report was performed as part of activities being conducted under the ''Technical Work Plan for: The Integrated Site Model, Revision 05'' (BSC 2004 [DIRS 169635]). The purpose of this revision is to bring the report up to current procedural requirements and address the Regulatory Integration Team evaluation comments. The work plan describes the scope, objectives, tasks, methodology, and procedures for this process

  2. Rock critics as 'Mouldy Modernists'

    Directory of Open Access Journals (Sweden)

    Becky Shepherd

    2011-09-01

    Full Text Available Contemporary rock criticism appears to be firmly tied to the past. The specialist music press valorise rock music of the 1960s and 1970s, and new emerging artists are championed for their ‘retro’ sounding music by journalists who compare the sound of these new artists with those included in the established ‘canon’ of rock music. This article examines the narrative tropes of authenticity and nostalgia that frame the retrospective focus of this contemporary rock writing, and most significantly, the maintenance of the rock canon within contemporary popular culture. The article concludes by suggesting that while contemporary rock criticism is predominately characterised by nostalgia, this nostalgia is not simply a passive romanticism of the past. Rather, this nostalgia fuels a process of active recontextualisation within contemporary popular culture.

  3. Hyaline globule-like structures in undifferentiated sarcoma cells of malignant müllerian mixed tumor of the fallopian tube.

    Science.gov (United States)

    Kuroda, Naoto; Inui, Yasunobu; Ohara, Masahiko; Hirouchi, Takashi; Mizuno, Keiko; Kubo, Ayumi; Hayashi, Yoshihiro; Enzan, Hideaki; Lee, Gang-Hong

    2007-03-01

    Malignant müllerian mixed tumors (MMMTs) of the fallopian tube are very rare neoplasms, and we present such a case with unusual findings here. A 57-year-old Japanese woman, after she received a medical checkup, underwent salpingo-oophorectomy on the suspicion of ovarian cancer. At the time of operation, the main tumor was present predominantly in the fallopian tube. Microscopically, the tumor consisted of carcinoma and sarcoma components. The carcinoma showed moderately to poorly differentiated adenocarcinoma. The sarcoma consisted of predominantly undifferentiated sarcoma and focally rhabdomyosarcomatous cells with abundant eosinophilic cytoplasm. Immunohistochemically, the differentiation toward rhabdomyosarcoma was confirmed. Interestingly, the cytoplasm of undifferentiated sarcoma cells contained hyaline globule-like structures. These structures showed a positive reaction for PAS, and these structures were not digested by the diastase pretreatment. Ultrastructurally, hyaline globule-like structures corresponded to lysosomes. Finally, pathologists should keep in mind that undifferentiated sarcoma cells in MMMT of the fallopian tube may contain hyaline globule-like structures in the cytoplasm.

  4. Comparative efficacy of tulathromycin versus a combination of florfenicol-oxytetracycline in the treatment of undifferentiated respiratory disease in large numbers of sheep

    Directory of Open Access Journals (Sweden)

    Mohsen Champour

    2015-09-01

    Full Text Available The objective of this study was to compare the efficacy of tulathromycin (TUL with a combination of florfenicol (FFC and long-acting oxytetracycline (LAOTC in the treatment of naturally occurring undifferentiated respiratory diseases in large numbers of sheep. In this study, seven natural outbreaks of sheep pneumonia in Garmsar, Iran were considered. From these outbreaks, 400 sheep exhibiting the signs of respiratory diseases were selected, and the sheep were randomly divided into two equal groups. The first group was treated with a single injection of TUL (dosed at 2.5 mg/kg body weight, and the second group was treated with concurrent injections of FFC (dosed at 40 mg/kg bwt and LAOTC (dosed at 20 mg/kg bwt. In the first group, 186 (93% sheep were found to be cured 5 days after the injection, and 14 (7% sheep needed further treatment, of which 6 (3% were cured, and 8 (4% died. In the second group, 172 (86% sheep were cured after the injections, but 28 (14% sheep needed further treatment, of which 10 (5% were cured, and 18 (9% died. This study revealed that TUL was more efficacious as compared to the combined treatment using FFC and LAOTC. As the first report, this field trial describes the successful treatment of undifferentiated respiratory diseases in large numbers of sheep. Thus, TUL can be used for the treatment of undifferentiated respiratory diseases in sheep. [J Adv Vet Anim Res 2015; 2(3.000: 279-284

  5. Aespoe Hard Rock Laboratory. The TASS-tunnel. Geological mapping

    Energy Technology Data Exchange (ETDEWEB)

    Hardenby, Carljohan (Vattenfall Power Consultant AB (Sweden)); Sigurdsson, Oskar (HAskGeokonsult AB (Sweden))

    2010-12-15

    The project entitled 'Sealing of tunnel at great depth' (Fintaetning av tunnel paa stort djup) needed a new tunnel in an area as undisturbed as possible and with cross-cutting water-bearing structures. The new tunnel, which was given the name TASS, was excavated on the -450 m level of SKB's Aespoe Hard Rock Laboratory (Aespoe HRL). The length of the tunnel is approximately 80 m and the theoretical tunnel area 19 m2. As is the case with all the other tunnels of the Aespoe HRL, the new tunnel has been geologically mapped. In addition, laser scanning combined with digital photography has been carried out. The tunnel was also used to test various types of explosives, borehole layouts and drilling techniques. The geological mapping of tunnel floor, walls and roof took place on four major occasions when a halt was made in tunnel excavation to allow for various tests. Before the mapping started on these occasions, laser scanning took place. The tunnel faces were mapped after each round (drilling, blasting and unloading). The present report describes the geological features of the tunnel and briefly how the laser scanning was performed. Water-bearing structures have been compared to similar structures in the neighbouring tunnels. The rock type names used here follow the old established Aespoe HRL nomenclature. Narrow (<0.1 m wide) dykes are normally mapped as fracture fillings. The dominating rock type is Aespoe diorite, which constitutes some 90 % of the rock mass. It is mostly mapped as fresh rock. . Minor constituents of the rock mass are fine-grained granite, hybrid rock, pegmatite, quartz veins/lenses and undifferentiated mafic rock. The mapping of fractures and deformation zones considers a number of parameters such as number of fractures, open/healed, width, length, description of fracture surfaces (roughness, planarity, etc), fracture filling, alteration and water. The deformation zones are discriminated into two main categories (&apos

  6. Rock.XML - Towards a library of rock physics models

    Science.gov (United States)

    Jensen, Erling Hugo; Hauge, Ragnar; Ulvmoen, Marit; Johansen, Tor Arne; Drottning, Åsmund

    2016-08-01

    Rock physics modelling provides tools for correlating physical properties of rocks and their constituents to the geophysical observations we measure on a larger scale. Many different theoretical and empirical models exist, to cover the range of different types of rocks. However, upon reviewing these, we see that they are all built around a few main concepts. Based on this observation, we propose a format for digitally storing the specifications for rock physics models which we have named Rock.XML. It does not only contain data about the various constituents, but also the theories and how they are used to combine these building blocks to make a representative model for a particular rock. The format is based on the Extensible Markup Language XML, making it flexible enough to handle complex models as well as scalable towards extending it with new theories and models. This technology has great advantages as far as documenting and exchanging models in an unambiguous way between people and between software. Rock.XML can become a platform for creating a library of rock physics models; making them more accessible to everyone.

  7. Efficient recovery of undifferentiated human embryonic stem cell cryopreserved with hydroxyethyl starch, dimethyl sulphoxide and serum replacement.

    Science.gov (United States)

    Orellana, Maristela Delgado; De Santis, Gil Cunha; Abraham, Kuruvilla Joseph; Fontes, Aparecida Maria; Magalhães, Danielle Aparecida Rosa; Oliveira, Viviane de Cássia; Costa, Everton de Brito Oliveira; Palma, Patrícia Vianna Bonini; Covas, Dimas Tadeu

    2015-08-01

    The therapeutic use of human embryonic stem cells (hESCs) is dependent on an efficient cryopreservation protocol for long-term storage. The aim of this study was to determine whether the combination of three cryoprotecting reagents using two freezing systems might improve hESC recovery rates with maintenance of hESC pluripotency properties for potential cell therapy application. Recovery rates of hESC colonies which were frozen in three cryoprotective solutions: Me2SO/HES/SR medium, Defined-medium® and Me2SO/SFB in medium solution were evaluated in ultra-slow programmable freezing system (USPF) and a slow-rate freezing system (SRF). The hESC pluripotency properties after freezing-thawing were evaluated. We estimated the distribution frequency of survival colonies and observed that independent of the freezing system used (USPF or SRF) the best results were obtained with Me2SO/HES/SR as cryopreservation medium. We showed a significant hESC recovery colonies rate after thawing in Me2SO/HES/SR medium were 3.88 and 2.9 in USPF and SRF, respectively. The recovery colonies rate with Defined-medium® were 1.05 and 1.07 however in classical Me2SO medium were 0.5 and 0.86 in USPF and SRF, respectively. We showed significant difference between Me2SO/HES/SR medium×Defined-medium® and between Me2SO/HES/SR medium×Me2SO medium, for two cryopreservation systems (Psystem which resulted in hESC colonies that remain undifferentiated, maintain their in vitro and in vivo pluripotency properties and genetic stability. This approach may be suitable for cell therapy studies. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. Tissue engineering approaches to develop decellularized tendon matrices functionalized with progenitor cells cultured under undifferentiated and tenogenic conditions

    Directory of Open Access Journals (Sweden)

    Daniele D’Arrigo

    2017-11-01

    Full Text Available Tendon ruptures and retractions with an extensive tissue loss represent a major clinical problem and a great challenge in surgical reconstruction. Traditional approaches consist in autologous or allogeneic grafts, which still have some drawbacks. Hence, tissue engineering strategies aimed at developing functionalized tendon grafts. In this context, the use of xenogeneic tissues represents a promising perspective to obtain decellularized tendon grafts. This study is focused on the identification of suitable culture conditions for the generation of reseeded and functional decellularized constructs to be used as tendon grafts. Equine superficial digital flexor tendons were decellularized, reseeded with mesenchymal stem cells (MSCs from bone marrow and statically cultured in two different culture media to maintain undifferentiated cells (U-MSCs or to induce a terminal tenogenic differentiation (T-MSCs for 24 hours, 7 and 14 days. Cell viability, proliferation, morphology as well as matrix deposition and type I and III collagen production were assessed by means of histological, immunohistochemical and semi-quantitative analyses. Results showed that cell viability was not affected by any culture conditions and active proliferation was maintained 14 days after reseeding. However, seeded MSCs were not able to penetrate within the dense matrix of the decellularized tendons. Nevertheless, U-MSCs synthesized a greater amount of extracellular matrix rich in type I collagen compared to T-MSCs. In spite of the inability to deeply colonize the decellularized matrix in vitro, reseeding tendon matrices with U-MSCs could represent a suitable method for the functionalization of biological constructs, considering also any potential chemoattractant capability of the newly deposed extracellular matrix to recruit resident cells. This bioengineering approach can be exploited to produce functionalized tendon constructs for the substitution of large tendon defects.

  9. Sarcoma indiferenciado primário no sistema nervoso central Primary undifferentiated sarcoma of the central nervous system

    Directory of Open Access Journals (Sweden)

    Milton Marcio Machota Junior

    2012-04-01

    Full Text Available INTRODUÇÃO: O sarcoma de sistema nervoso central (SNC é uma neoplasia rara, com incidência de 0,1% a 4,3% dos tumores intracranianos. São tumores agressivos com prognóstico reservado e a maioria é tratada com ressecção radical. RELATO: Homem, 29 anos, com episódios de crises convulsivas e diagnóstico de hemorragia intraparenquimatosa. Durante a cirurgia, foi identificada lesão bem delimitada. A histologia demonstrou neoplasia fusocelular com atipias e numerosas mitoses. Os únicos marcadores imuno-histoquímicos positivos foram vimentina e S-100. O diagnóstico foi de sarcoma indiferenciado de alto grau. CONCLUSÃO: No diagnóstico diferencial de sarcomas de SNC, devem-se excluir lesões metastáticas e gliossarcoma.INTRODUCTION: The central nervous system (CNS sarcoma is a rare neoplasm with an incidence of 0.1% to 4.3% in intracranial tumors. They are aggressive with poor prognosis, and mostly treated with radical resection. REPORT: 29 year-old male patient with episodes of seizures and diagnosed with intraparenchymal hemorrhage. During the surgery a well-defined lesion was identified. Histology showed a spindle cell neoplasm with atypia and numerous mitoses. The immunohistochemical markers were positive only for vimentin and S-100. The diagnosis was high-grade undifferentiated sarcoma. CONCLUSION: Metastatic lesions and gliosarcoma should be excluded in the differential diagnosis of CNS sarcomas.

  10. Early Cretaceous Tertiary magmatism in Eastern Paraguay (western Paraná basin): geological, geophysical and geochemical relationships

    Science.gov (United States)

    Comin-Chiaramonti, P.; Cundari, A.; DeGraff, J. M.; Gomes, C. B.; Piccirillo, E. M.

    1999-11-01

    Structural characteristics of Eastern Paraguay, at the westernmost side of the Paraná basin, show that the tectonics in the region is extensional. This tectonics controlled the emplacement of the alkaline rocks in Early Cretaceous-Tertiary times. Major structures are NW-trending zones of tectonic subsidence, i.e. the 'Asunción-Sapucai-Villarrica' and 'Amambay' grabens of the central and northeastern regions of Eastern Paraguay, respectively. Early Cretaceous potassic magmatism is widespread in the 'gravity lows', and predates the tholeiitic Early Cretaceous magmatism in the northern areas, whereas in central Paraguay it postdates the tholeiitic flood basalts. Sodic alkaline rocks (late Early Cretaceous-Tertiary) are widespread in cratonized areas of the La Plata Craton. The Early Cretaceous uncontaminated potassic rocks (and tholeiites) have geochemical features of 'subduction type' (e.g. Ta-Nb negative anomaly), while the contrary occurs for the closely associated younger sodic magmatism. This implies different mantle sources consistently with Sr-Nd isotopes which are Rb-Nd enriched and depleted for the potassic and sodic rocks, respectively. T DM(Nd) model ages point to two notional distinct metasomatic events occurred in Middle and Late Proterozoic times. A contribution of asthenospheric melts from Tristan da Cunha Plume is not appreciable. We suggest that the source(s) of the recurrent potassic magmatism and interposed tholeiitic event may not be easily accounted for by the Tristan da Cunha plume hypothesis.

  11. Rock and soil rheology

    International Nuclear Information System (INIS)

    Cristescu, N.; Ene, H.I.

    1988-01-01

    The aim of the Euromech Colloquium 196 devoted to Rock and Soil Rheology is to review some of the main results obtained in the last years in this field of research and also to formulate some of the major not yet solved problems which are now under consideration. Exchange of opinions and scientific discussions are quite helpful mainly in those areas where some approaches are controversial and the progress made is quite fast. That is especially true for the rheology of geomaterials, domain of great interest for mining and petroleum engineers, engineering geology, seismology, geophysics, civil engineering, nuclear and industrial waste storage, geothermal energy storage, caverns for sports, culture, telecommunications, storage of goods and foodstuffs (cold, hot and refrigerated storages), underground oil and natural gas reservoirs etc. Some of the last obtained results are mentioned in the present volume. (orig./HP)

  12. Rock the Globe

    CERN Multimedia

    Laëtitia Pedroso

    2010-01-01

    Created in 2005, the Swiss rock band "Wind of Change" is now candidate for the Eurovision Song Contest 2011 with a new song " Night & Light " with the music video filmed at CERN.   With over 20 gigs under their belt and two albums already released, the five members of the band (Alex Büchi, vocals; Arthur Spierer, drums; David Gantner, bass; Romain Mage and Yannick Gaudy, guitar) continue to excite audiences. For their latest composition "Night & Light", the group filmed their music video in the Globe of Science and Innovation. Winning the Eurovision contest would be a springboard in their artistic career for these young musicians. The selection results will be available December 11, 2010.      

  13. Water level fluctuations due to earth tides in a well pumping from slightly fractured crystalline rock

    International Nuclear Information System (INIS)

    Marine, I.W.

    1975-01-01

    J At the Savannah River plant of the Atomic Energy Commission near Aiken, South Carolina, there are three distinct groundwater systems: the coastal plain sediments, the crystalline metamorphic rocks, and a buried Triassic basin. The coastal plain sediments include several Cretaceous and Tertiary granular aquifers and aquicludes, the total thickness being about 305 m. Below these sediments, water occurs in small fractures in crystalline metamorphic rock (hornblende schist and gneiss with lesser amounts of quartzite). Water level fluctuations due to earth tides are recorded in the crystalline metamorphic rock system and in the coastal plain sediments. No water level fluctuations due to earth tides have been observed in wells in the Triassic rock because of the very low permeability. The water level fluctuations due to earth tides in the crystalline rock are about 10 cm, and those in the sediments are about 1.8 cm. The use of water level fluctuations due to earth tides to calculate porosity appears to present practical difficulties both in the crystalline metamorphic rock system and in the coastal plain sediments. In a 1-yr pumping test on a well in the crystalline metamorphic rock the flow was controlled to within 0.1 percent of the total discharge, which was 0.94 1/s. The water level fluctuations due to earth tides in the pumping well were 10 cm, the same as when this well was not being pumped. (U.S.)

  14. Age of Tertiary volcanic rocks on the West Greenland continental margin

    DEFF Research Database (Denmark)

    Larsen, Lotte M.; Pedersen, Asger Ken; Tegner, Christian

    2016-01-01

    Radiometric ages for undated parts of the volcanic succession and intrusions in West Greenland were obtained by the 40Ar–39Ar incremental heating method. Acceptable crystallization ages were obtained for 27 samples. Combined with published results the new data provide a volcanic stratigraphy corr...

  15. Upper Cretaceous source rocks of Northern South America

    Energy Technology Data Exchange (ETDEWEB)

    Talukdar, S.C. (DGSI, The Woodland, TX (United States)); DeToni, B. (Intevep, Los Teques (Venezuela)); Marcano, F. (Maraven, Caracas (Venezuela)); Sweeney, J. (Lawrence Livermore National Lab., CA (United States)); Rangel, A. (ICP, Bucaramanga (Colombia))

    1993-02-01

    Upper Cretaceous source rocks sourced most of the oil accumulations in Trinidad, Venezuela and Colombia. Extensive areas of mature to overmature organic-rich, calcareous shales and limestones are present in basins throughout the area. Paleogeographic reconstruction shows deposition of the source rocks in open marine, outer shelf-inner slope environments on the passive margin of the Cretaceous South American continent. Deposition is primarily related to marine transgressions caused by eustatic sea level changes and to Upper Cretaceous oceanic anoxic events. Sedimentological and geochemical data show regional variations in organic facies across the huge Upper Cretaceous shelf margin. Source rocks deposited in the pelagic domain in outer shelf-slope towards north and northwest are commonly organic-rich and contain oil prone, type II kerogen with essentially marine amorphous organic matter. In this organic facies, variations in organic content were primary controlled by changes in marine organic productivity and sedimentation rate, while the kerogen quality was influenced by short-term fluctuations in the thickness of oxygen-minimum layer. Source rocks deposited in outer neritic environment, towards south and southeast are usually less organic-rich and include oil and gas prone kerogen between types II and III with both marine amorphous and terrestrial organic matter. Temporal changes in the influx of terrestrial organic matter and fluctuations in relative anoxicity controlled the kerogen quality. Hydrocarbon generation from these source rocks occurred during the Tertiary. Basin modelling quantifies oil and gas generation and expulsion from the various organic facies. Oil characteristics can be predicted by the organic facies in the effective source area.

  16. Rock Art in Kurdistan Iran

    Directory of Open Access Journals (Sweden)

    Jamal Lahafian

    2013-12-01

    Full Text Available Kurdistan, with great potential and prehistoric resources, has numerous petroglyphs in different areas of the province. During the last 14 years of extensive field study, more than 30 sites of rock art have been identified and introduced by the author. In this article, we summarize these rock art areas in Iranian Kurdistan.

  17. Beach rock from Goa Coast

    Digital Repository Service at National Institute of Oceanography (India)

    Setty, M.G.A.P.; Wagle, B.G.

    Beach rock is a common rock type in many parts of the southern hemisphere and also some areas north of the equator. Its distribution particularly in the Indian Ocean islands and atolls and coasts of India is reviewed. The mineralogic and faunal...

  18. Rock strength under explosive loading

    International Nuclear Information System (INIS)

    Rimer, N.; Proffer, W.

    1993-01-01

    This presentation emphasizes the importance of a detailed description of the nonlinear deviatoric (strength) response of the surrounding rock in the numerical simulation of underground nuclear explosion phenomenology to the late times needed for test ban monitoring applications. We will show how numerical simulations which match ground motion measurements in volcanic tuffs and in granite use the strength values obtained from laboratory measurements on small core samples of these rocks but also require much lower strength values after the ground motion has interacted with the rock. The underlying physical mechanisms for the implied strength reduction are not yet well understood, and in fact may depend on the particular rock type. However, constitutive models for shock damage and/or effective stress have been used successfully at S-Cubed in both the Geophysics Program (primarily for DARPA) and the Containment Support Program (for DNA) to simulate late time ground motions measured at NTS in many different rock types

  19. Rock suitability classification RSC 2012

    Energy Technology Data Exchange (ETDEWEB)

    McEwen, T. (ed.) [McEwen Consulting, Leicester (United Kingdom); Kapyaho, A. [Geological Survey of Finland, Espoo (Finland); Hella, P. [Saanio and Riekkola, Helsinki (Finland); Aro, S.; Kosunen, P.; Mattila, J.; Pere, T.

    2012-12-15

    This report presents Posiva's Rock Suitability Classification (RSC) system, developed for locating suitable rock volumes for repository design and construction. The RSC system comprises both the revised rock suitability criteria and the procedure for the suitability classification during the construction of the repository. The aim of the classification is to avoid such features of the host rock that may be detrimental to the favourable conditions within the repository, either initially or in the long term. This report also discusses the implications of applying the RSC system for the fulfilment of the regulatory requirements concerning the host rock as a natural barrier and the site's overall suitability for hosting a final repository of spent nuclear fuel.

  20. ROCK inhibitors in ocular disease

    Directory of Open Access Journals (Sweden)

    Eva Halasz

    2016-12-01

    Full Text Available Rho kinases (ROCKs have a crucial role in actin-cytoskeletal reorganization and thus are involved in broad aspects of cell motility, from smooth muscle contraction to neurite outgrowth. The first marketed ROCK inhibitor, called fasudil, has been used safely for treatment of cerebral vasospasm since 1995 in Japan. During the succeeding decades ROCK inhibitors have been applied in many pathological conditions from central nervous system disorders to cardiovascular disease as potential therapeutic agents or experimental tools to help understand the underlying (pathomechanisms. In 2014, a fasudil derivate named ripasudil was accepted for clinical use in glaucoma and ocular hypertension. Since ROCK kinases are widely expressed in ocular tissues, they have been implicated in the pathology of many ocular conditions such as corneal dysfunction, glaucoma, cataract, diabetic retinopathy, age-related macular degeneration, and retinal detachment. This paper aims to provide an overview of the most recent status/application of ROCK inhibitors in the field of eye disease.

  1. Lower Tertiary sand development in Viking graben, North Sea

    Energy Technology Data Exchange (ETDEWEB)

    Morton, A.C.

    1982-10-01

    The Viking graben forms the northernmost part of the North Sea basin. During the Paleocene and early Eocene it was the locus of depositionof thick clastic sequences which now act as the reservoir rocks for several major hydrocarbon accumulations, notably the Frigg gas field, the Heimdal and Blader oil fields, and the recent Chevron discovery in United Kingdom block 2/10. A regional study of lower tertiary sands in the Viking graben, northern North Sea, involving heavy mineral analysis, geophysical log interpretation, and palynologic dating, has led to the successful differentiation of sand bodies, with two distinct source areas being recognized. These both lie on the Orkney-Shetland platform, one being the metamorphic basement in the north, the other the preexisting sediments to the south, probably of Late Jurassic age. Correlation of sand bodies by these means has led to a more complete breakdown of the depositional history of the area. Four phases of basinal subsidence and source-area uplift have been recognized in this way, an dthese are correlated with similar events in te central North Sea. The changes in subsidence pattern and source-area uplift are related to events in the North Atlantic prior to crustal separation between Greenland and Rockall.

  2. Solvent effects on the magnetic shielding of tertiary butyl alcohol

    African Journals Online (AJOL)

    )4 and tetramethyl ammonium cation N(CH3)4(+) have also been presented. KEY WORDS: Solvent effects, Magnetic shielding, Tertiary butyl alcohol, Tertiary butyl amine, Continuum solvation calculations, Chemical shift estimation methods

  3. Sexual promiscuity among female undergraduates in tertiary ...

    African Journals Online (AJOL)

    The study focused on sexual promiscuity among female undergraduates and the attendant health implications. It was carried out in the tertiary institutions in Imo State using 415 final year degree students drawn from four institutions in the State. Three research questions were formulated to guide the study. The design was a ...

  4. Indigenous Students in the Tertiary Education Sector

    Science.gov (United States)

    Bandias, Susan; Fuller, Don; Larkin, Steven

    2014-01-01

    Important recent objectives of indigenous education policy in Australia have been aimed at redressing indigenous economic and social disadvantage through increasing student retention, progression and completion rates in both compulsory and post-compulsory education. The two sectors of the tertiary education system, vocational education and…

  5. American Tertiary mollusks of the genus Clementia

    Science.gov (United States)

    Woodring, W.P.

    1927-01-01

    Aside from its value as an aid in determining the age of Tertiary beds, the chief interest of the genus Clementia lies in the anomalous features of its present and former distribution. An attempt is made in this paper to trace its geologic history, to point out its paleobiologic significance, and to describe all the known American Tertiary species. The fossils from Colombia used in preparing this report were collected during explorations made under the direction of Dr. 0. B. Hopkins, chief geologist of the Imperial Oil Co. (Ltd.), who kindly donated them to the United States National Museum. Dr. T. Wayland Vaughan, of the Scripps Institution of Oceanography, furnished information relating to specimens collected by him in Mexico. Dr. Bruce L. Clark, of the University of California; Dr. G. Dallas Hanna, of the California Academy of Sciences; Dr. H. A. Pilsbry, of the Philadelphia Academy of Natural Sciences; and Dr. W. D. Matthew, of the American Museum of Natural History, generously loaned type specimens and other material. Doctor Clark and Doctor Hanna also gave information concerning the Tertiary species from California. Mr. Ralph B. Stewart, of the University of California, read the manuscript, and I have taken advantage of his suggestions. I am also indebted to Mr. L. R. Cox, of the British Museum, for information relating to the fossil species from Persia, Zanzibar, and Burma, and to Dr. Axel A. Olsson, of the International Petroleum Co., for data concerning undescribed Tertiary species from Peru.

  6. Misconception of emergency contraception among tertiary school ...

    African Journals Online (AJOL)

    Objective: To assess the degree of awareness and use of emergency contraception among tertiary school students in Akwa Ibom State, Nigeria. Design: A self-administered questionnaire survey. Setting: The Akwa Ibom State Polytechnic, Ikot Osurua, located on the outskirts of Ikot Ekpene local government area between ...

  7. RELIGIOUS EXTREMISM AS A CHALLENGE TO TERTIARY ...

    African Journals Online (AJOL)

    IK

    2016-07-01

    Jul 1, 2016 ... tertiary institutions in Nigeria, through General Studies, should educate the youth to be self- reliant so that they are not lured by religious extremists to achieve their political and economic agenda. Publication of well researched papers and books that contribute to the study of religions and cultures should be ...

  8. Recruitment Of International Students Into Cameroon Tertiary ...

    African Journals Online (AJOL)

    This paper highlights the importance of Cameroon\\'s tertiary institutions\\' cooperation links with other African Universities given the rebirth of Organisation of African Unity as African Union, and the New Partnership for Africa Development (NEPAD). The present system of recruiting international students is haphazardly been ...

  9. Modelling the harmonized tertiary Institutions Salary Structure ...

    African Journals Online (AJOL)

    This paper analyses the Harmonized Tertiary Institution Salary Structure (HATISS IV) used in Nigeria. The irregularities in the structure are highlighted. A model that assumes a polynomial trend for the zero step salary, and exponential trend for the incremental rates, is suggested for the regularization of the structure.

  10. Economics of Tertiary Education - Challenges and dynamics of the public tertiary education in Albania

    Directory of Open Access Journals (Sweden)

    Gledian Llatja

    2016-07-01

    Full Text Available The tertiary education is a critic mechanism for the socio-economic progress, for individuals who aspire a brighter future and it is also considered an important catalyzer of the economic mobility (Department of Treasury and Department of Education, 2012, 2. Based on the positive role and impact that the tertiary education has on the sustainable development, President Obama once stated that it is of damage to treat education as a luxurious public service. In line with the general considerations about the tertiary education in the U.S. the parallel comparison with Albania comes as a direct interpretation of utopia in the education policy-making. As policies are usually drafted based on data and findings, in the case of Albania there is a lack of data on expenses on tertiary education as share of GDP. This stands also for the main limitation of the paper.

  11. Tertiary Education in the Czech Republic: The Pathway to Change

    Science.gov (United States)

    Pesik, Richard; Gounko, Tatiana

    2011-01-01

    This article analyzes recent policy proposals to reform Czech tertiary education. A brief overview of the evolution of Czech tertiary education presents the background against which emerging policy trends in education are examined. We relate the changes in tertiary education to the policy framework and recommendations of the OECD, underpinned by…

  12. Uranium series, volcanic rocks

    Science.gov (United States)

    Vazquez, Jorge A.

    2014-01-01

    Application of U-series dating to volcanic rocks provides unique and valuable information about the absolute timing of crystallization and differentiation of magmas prior to eruption. The 238U–230Th and 230Th-226Ra methods are the most commonly employed for dating the crystallization of mafic to silicic magmas that erupt at volcanoes. Dates derived from the U–Th and Ra–Th methods reflect crystallization because diffusion of these elements at magmatic temperatures is sluggish (Cherniak 2010) and diffusive re-equilibration is insignificant over the timescales (less than or equal to 10^5 years) typically associated with pre-eruptive storage of nearly all magma compositions (Cooper and Reid 2008). Other dating methods based on elements that diffuse rapidly at magmatic temperatures, such as the 40Ar/39Ar and (U–Th)/He methods, yield dates for the cooling of magma at the time of eruption. Disequilibrium of some short-lived daughters of the uranium series such as 210Po may be fractionated by saturation of a volatile phase and can be employed to date magmatic gas loss that is synchronous with volcanic eruption (e.g., Rubin et al. 1994).

  13. They will rock you!

    CERN Multimedia

    Anaïs Schaeffer

    2013-01-01

    On 30 September, CERN will be the venue for one of the most prestigious events of the year: the concert for the Bosons&More event, the Organization’s celebration of the remarkable performance of the LHC and all its technical systems, as well as the recent fundamental discoveries. Topping the bill will be the Orchestre de la Suisse Romande, the CERN Choir, the Zürcher Sing-Akademie and the Alan Parsons Live Project rock group, who have joined forces to create an unforgettable evening’s entertainment.   The Orchestre de la Suisse Romande, directed by Maestro Neeme Järvi, artistic and musical director of the OSR. (Image: Grégory Maillot). >>> From the Orchestre de la Suisse Romande… Henk Swinnen, General Manager of the Orchestre de la Suisse Romande (OSR), answers some questions for the CERN Bulletin, just a few days before the event. How did this project come about? When CERN invited us to take part in the B...

  14. A comparison of florfenicol and tilmicosin for the treatment of undifferentiated fever in feedlot calves in western Canada.

    Science.gov (United States)

    Jim, G K; Booker, C W; Guichon, P T; Schunicht, O C; Wildman, B K; Johnson, J C; Lockwood, P W

    1999-01-01

    A field trial was performed under commercial feedlot conditions in western Canada to compare the efficacy of florfenicol and tilmicosin for the treatment of undifferentiated fever (UF) in calves that received metaphylactic tilmicosin upon arrival at the feedlot. One thousand and eighty recently weaned, auction market derived, crossbred beef calves suffering from UF were allocated to one of 2 experimental groups as follows: florfenicol, which was intramuscular (i.m.) florfenicol administered at the rate of 20 mg/kg body weight (BW) at the time of allocation (Day 0) and again 48 h later, or tilmicosin, which was subcutaneous (s.c.) tilmicosin administered once at the rate of 10 mg/kg BW on day 0. Five hundred and forty-four animals were allocated to the florfenicol group and 536 animals were allocated to the tilmicosin group. The chronicity, wastage, overall mortality, and bovine respiratory disease (BRD) mortality rates were significantly (P florfenicol group than in the tilmicosin group. There were no significant (P > or = 0.05) differences in first UF relapse, second UF relapse, hemophilosis mortality, or miscellaneous mortality rates between the florfenicol and tilmicosin groups. Average daily gain (ADG) from arrival at the feedlot to the time of implanting and ADG from allocation to the time of implanting were significantly (P florfenicol group as compared with the tilmicosin group. There were no significant (P > or = 0.05) differences in arrival weight, allocation weight, implanting weight, or ADG from arrival to allocation between the experimental groups. In the economic analysis, there was an advantage of $18.83 CDN per animal in the florfenicol group. The results of this study indicate that florfenicol is superior to tilmicosin for the treatment of UF because of lower chronicity, wastage, overall mortality, and BRD mortality rates. However, interpretation of these observations must take into consideration the fact that these calves received meta

  15. Subcellular Distribution of S-Nitrosylated H-Ras in Differentiated and Undifferentiated PC12 Cells during Hypoxia.

    Science.gov (United States)

    Barbakadze, Tamar; Goloshvili, Galina; Narmania, Nana; Zhuravliova, Elene; Mikeladze, David

    2017-10-01

    Hypoxia or exposure to excessive reactive oxygen or nitrogen species could induce S-nitrosylation of various target proteins, including GTPases of the Ras-superfamily. Under hypoxic conditions, the Ras-protein is translocated to the cytosol and interacts with the Golgi complex, endoplasmic reticulum, mitochondria. The mobility/translocation of Ras depend on the cells oxidative status. However, the importance of relocated Snitrosylated- H-Ras (NO-H-Ras) in proliferation/differentiation processes is not completely understood. We have determined the content of soluble- and membrane-bound-NO-HRas in differentiated (D) and undifferentiated (ND) rat pheochromocytoma (PC12) cells under hypoxic and normoxic conditions. In our experimental study, we analyzed NO-H-Ras levels under hypoxic/normoxic conditions in membrane and soluble fractions of ND and D PC12 cells with/without nitric oxide donor, sodium nitroprusside (SNP) treatment. Cells were analyzed by the S-nitrosylated kit, immunoprecipitation, and Western blot. We assessed the action of NO-H-Ras on oxidative metabolism of isolated mitochondria by determining mitochondrial hydrogen peroxide generation via the scopoletin oxidation method and ATPproduction as estimated by the luminometric method. Hypoxia did not influence nitrosylation of soluble H-Ras in ND PC12 cells. Under hypoxic conditions, the nitrosylation of soluble-H-Ras greatly decreased in D PC12 cells. SNP didn't change the levels of nitrosylation of soluble-H-Ras, in either hypoxic or normoxic conditions. On the other hand, hypoxia, per se, did not affect the nitrosylation of membrane-bound-H-Ras in D and ND PC12 cells. SNP-dependent nitrosylation of membrane-bound-H-Ras greatly increased in D PC12 cells. Both unmodified normal and mutated H-Ras enhanced the mitochondrial synthesis of ATP, whereas the stimulatory effects on ATP synthesis were eliminated after S-nitrosylation of H-Ras. According to the results, it may be proposed that hypoxia can decrease S

  16. Awareness of malaria and treatment-seeking behaviour among persons with acute undifferentiated fever in the endemic regions of Myanmar.

    Science.gov (United States)

    Naing, Phyo Aung; Maung, Thae Maung; Tripathy, Jaya Prasad; Oo, Tin; Wai, Khin Thet; Thi, Aung

    2017-01-01

    Myanmar has a high burden of malaria with two-third of the population at risk of malaria. One of the basic elements of the Roll Back Malaria Initiative to fight against malaria is early diagnosis and treatment within 24 h of fever. Public awareness about malaria is a key factor in malaria prevention and control and in improving treatment-seeking behaviour. A large community-based survey was carried out in 27 townships of malaria endemic regions in Myanmar in 2015 which reported on the knowledge, behaviour and practices around malaria in the general population. We used the data already collected in this survey to assess (i) general public awareness of malaria and (ii) treatment-seeking behaviour and associated factors among persons with acute undifferentiated fever. A total of 6597 respondents from 6625 households were interviewed (response rate of 99.5%). About 85% of the respondents were aware that mosquito bite was the mode of transmission of malaria and 90% mentioned that malaria was preventable. However, only 16% of the respondents knew about anti-malaria drug resistance. There were certain misconceptions about the transmission of malaria such as dirty water, same blood group, sharing shelter, sleeping/eating together and poor hygiene. Health facility staff were the most common source of information about malaria (80%). Nearly one-fourth (23%) of the respondents with fever resorted to self-medication. Around 28% of the respondents with fever underwent blood testing, less than half of whom (44%) were tested within 24 h. Elderly age group, females, those with poor knowledge about malaria and those residing in non-Regional Artemisinin Resistance Initiative townships were associated with poor treatment-seeking behaviour in case of fever. Although there is fair knowledge on mosquito bite as a mode of transmission and prevention of malaria, there are some misconceptions about transmission of malaria. Those having poor knowledge about malaria have poor treatment

  17. Dynamics of rock varnish formation

    Energy Technology Data Exchange (ETDEWEB)

    Raymond, R. Jr.; Reneau, S.L.; Guthrie, G.D. Jr.; Bish, D.L.; Harrington, C.D.

    1991-01-01

    Our studies of rock varnish from the southwestern United States suggest that the Mn-phase in rock varnish has neither the chemistry nor the crystal structure of birnessite. Rather, the Mn-rich phase is non-crystalline and contains Ba, Ca, Fe, Al, and P. Unknowns concerning the formation of this non-crystalline Mn phase must be resolved before researchers are able to define chemical parameters of rock varnish formation based upon conditions of formation of the Mn phase. 6 refs., 9 figs.

  18. Space Weathering of Lunar Rocks

    Science.gov (United States)

    Noble, S. K.; Keller, L. P.; Christoffersen, R.; Rahman, Z.

    2012-01-01

    All materials exposed at the lunar surface undergo space weathering processes. On the Moon, boulders make up only a small percentage of the exposed surface, and areas where such rocks are exposed, like central peaks, are often among the least space weathered regions identified from remote sensing data. Yet space weathered surfaces (patina) are relatively common on returned rock samples, some of which directly sample the surface of larger boulders. Because, as witness plates to lunar space weathering, rocks and boulders experience longer exposure times compared to lunar soil grains, they allow us to develop a deeper perspective on the relative importance of various weathering processes as a function of time.

  19. Multiverso: Rock'n'Astronomy

    Science.gov (United States)

    Caballero, J. A.

    2012-05-01

    In the last few years, there have been several projects involving astronomy and classical music. But have a rock band ever appeared at a science conference or an astronomer at a rock concert? We present a project, Multiverso, in which we mix rock and astronomy, together with poetry and video art (Caballero, 2010). The project started in late 2009 and has already reached tens of thousands people in Spain through the release of an album, several concert-talks, television, radio, newspapers and the internet.

  20. Mineral Detector for Igneous Rocks

    Science.gov (United States)

    Ishikawa, S. T.; Hart, S. D.; Gulick, V. C.

    2010-12-01

    We present a Raman spectral analysis tool that uses machine learning algorithms to classify pure minerals in igneous rocks. Experiments show greater than 90% accuracy classifying a test set of pure minerals against a database of similar reference minerals using an artificial neural network. Efforts are currently underway to improve this tool for use as a mineral detector in rock samples, an important milestone toward autonomously classifying rocks based on spectral, and previous imaging work. Although pure mineral classification has been widely successful, applying the same methods to rocks is difficult because the spectra may represent a combination of multiple, and often competing, mineral signatures. In such cases some minerals may appear with more intensity than others resulting in masking of weaker minerals. Furthermore, with our particular spectrometer (852 nm excitation, ~50 micron spot size), minerals such as potassium feldspar fluoresce, both obscuring its characteristic Raman features and suppressing those of weaker minerals. For example, plagioclase and quartz, two key minerals for determining the composition of igneous rocks, are often hidden by minerals such as potassium feldspar and pyroxene, and are consequently underrepresented in the spectral analysis. These technicalities tend to skew the perceived composition of a rock from its actual composition. Despite these obstacles, an experiment involving a training set of 26 minerals (plagioclase, potassium feldspar, pyroxene, olivine, quartz) and a test set of 57 igneous rocks (basalt, gabbro, andesite, diorite, dacite, granodiorite, rhyolite, granite) shows that generalizations derived from their spectral data are consistent with expected trends: as rock composition goes from felsic to mafic there is a marked increase in the detection of minerals such as plagioclase and pyroxene along with a decrease in the detection of minerals such as quartz and potassium feldspar. The results suggest that phaneritic

  1. Fault rocks and uranium mineralization

    International Nuclear Information System (INIS)

    Tong Hangshou.

    1991-01-01

    The types of fault rocks, microstructural characteristics of fault tectonite and their relationship with uranium mineralization in the uranium-productive granite area are discussed. According to the synthetic analysis on nature of stress, extent of crack and microstructural characteristics of fault rocks, they can be classified into five groups and sixteen subgroups. The author especially emphasizes the control of cataclasite group and fault breccia group over uranium mineralization in the uranium-productive granite area. It is considered that more effective study should be made on the macrostructure and microstructure of fault rocks. It is of an important practical significance in uranium exploration

  2. Stratigraphy, geochemistry and tectonic significance of the Oligocene magmatic rocks of western Oaxaca, southern Mexico

    Science.gov (United States)

    Martiny, Barbara; Martínez-Serrano, Raymundo G.; Morán-Zenteno, Dante J.; Macías-Romo, Consuelo; Ayuso, Robert A.

    2000-03-01

    In western Oaxaca, Tertiary magmatic activity is represented by extensive plutons along the continental margin and volcanic sequences in the inland region. K-Ar age determinations reported previously and in the present work indicate that these rocks correspond to a relatively broad arc in this region that was active mainly during the Oligocene (˜35 to ˜25 Ma). In the northern sector of western Oaxaca (Huajuapan-Monte Verde-Yanhuitlán), the volcanic suite comprises principally basaltic andesite to andesitic lavas, overlying minor silicic to intermediate volcaniclastic rocks (epiclastic deposits, ash fall tuffs, ignimbrites) that were deposited in a lacustrine-fluvial environment. The southern sector of the volcanic zone includes the Tlaxiaco-Laguna de Guadalupe region and consists of intermediate to silicic pyroclastic and epiclastic deposits, with silicic ash fall tuffs and ignimbrites. In both sectors, numerous andesitic to dacitic hypabyssal intrusions (stocks and dikes) are emplaced at different levels of the sequence. The granitoids of the coastal plutonic belt are generally more differentiated than the volcanic rocks that predominate in the northern sector and vary in composition from granite to granodiorite. The studied rocks show large-ion lithophile element (LILE) enrichment (K, Rb, Ba, Th) relative to high-field-strength (HFS) elements (Nb, Ti, Zr) that is characteristic of subduction-related magmatic rocks. On chondrite-normalized rare earth element diagrams, these samples display light rare earth element enrichment (LREE) and a flat pattern for the heavy rare earth elements (HREE). In spite of the contrasting degree of differentiation between the coastal plutons and inland volcanic rocks, there is a relatively small variation in the isotopic composition of these two suites. Initial 87Sr/ 86Sr ratios obtained and reported previously for Tertiary plutonic rocks of western Oaxaca range from 0.7042 to 0.7054 and ɛNd values, from -3.0 to +2.4, and for the

  3. Stratigraphy, geochemistry and tectonic significance of the Oligocene magmatic rocks of western Oaxaca, southern Mexico

    Science.gov (United States)

    Martiny, B.; Martinez-Serrano, R. G.; Moran-Zenteno, D. J.; MacIas-Romo, C.; Ayuso, R.A.

    2000-01-01

    In Western Oaxaca, Tertiary magmatic activity is represented by extensive plutons along the continental margin and volcanic sequences in the inland region. K-Ar age determinations reported previously and in the present work indicate that these rocks correspond to a relatively broad arc in this region that was active mainly during the Oligocene (~ 35 to ~ 25 Ma). In the northern sector of western Oaxaca (Huajuapan-Monte Verde-Yanhuitlan), the volcanic suite comprises principally basaltic andesite to andesitic lavas, overlying minor silicic to intermediate volcaniclastic rocks (epiclastic deposits, ash fall tuffs, ignimbrites) that were deposited in the lacustrine-fluvial environment. The southern sector of the volcanic zone includes the Tlaxiaco-Laguna de Guadalupe region and consists of intermediate to silicic pyroclastic and epiclastic deposits, with silicic ash fall tuffs and ignimbrites. In both sectors, numerous andesitic to dacitic hypabyssal intrusions (stocks and dikes) were emplaced at different levels of the sequence. The granitoids of the coastal plutonic belt are generally more differentiated than the volcanic rocks that predominate in the northern sector and vary in composition from granite to granodiorite. The studied rocks show large-ion lithophile element (LILE) enrichment (K, Rb, Ba, Th) relative to high-field-strength (HFS) elements (Nb, Ti, Zr) that is characteristic of subduction-related magmatic rocks. On chondrite-normalized rare earth element diagrams, these samples display light rare earth element enrichment (LREE) and a flat pattern for the heavy rare earth elements (HREE). In spite of the contrasting degree of differentiation between the coastal plutons and inland volcanic rocks, there is a relatively small variation in the isotopic composition of these two suites. Initial 87Sr/86Sr ratios obtained and reported previously for Tertiary plutonic rocks of western Oaxaca range from 0.7042 to 0.7054 and ??Nd values, from -3.0 to +2.4, and for

  4. A comparison of the clinical field efficacy and safety of florfenicol and tilmicosin for the treatment of undifferentiated bovine respiratory disease of cattle in western Canada.

    Science.gov (United States)

    Hoar, B R; Jelinski, M D; Ribble, C S; Janzen, E D; Johnson, J C

    1998-01-01

    We compared the field efficacy of a new antibiotic, florfenicol, with tilmicosin in the treatment of naturally occurring undifferentiated bovine respiratory disease. Beef calves with rectal temperatures greater than 40.5 degrees C and signs compatible with undifferentiated bovine respiratory disease were entered into the trial. Calves were randomly assigned to receive either florfenicol (20 mg/kg bodyweight intramuscularly; 2 injections 48 h apart) or tilmicosin (10 mg/kg bodyweight subcutaneously; 1 injection). Clinical measures of efficacy included mortality, rectal temperature, illness index score, assessment of treatment success or failure, and the number of relapses or reinfections. Performance was assessed based on weight gains from day 0 to day 90. Two hundred and twenty calves entered the trial; 112 received florfenicol and 108 received tilmicosin. Seventeen deaths occurred between day 0 and day 90, but only 10 during the 28-day trial period. Seven calves receiving tilmicosin died, compared with 3 receiving florfenicol (P = 0.20). Of the 220 initial treatments, 45 (20%) were categorized as treatment failures; 27 in the tilmicosin group and 18 in the florfenicol group (P = 0.10). The number of calves experiencing a 2nd relapse was significantly different, with 17 of 30 (57%) calves on tilmicosin compared with 7 of 26 (27%) calves on florfenicol relapsing at least twice (P = 0.02). Average daily gains over 90 days were 1.55 kg/day for florfenicol-treated calves and 1.51 kg/day for tilmicosin-treated calves. No significant adverse reactions were noticed with either drug. Results indicate that florfenicol and tilmicosin are comparable in the treatment of undifferentiated bovine respiratory disease in western Canada. Images Figure 2. Figure 3. PMID:9524721

  5. The effect of caffeine on p53-dependent radioresponses in undifferentiated mouse embryonal carcinoma cells after X-ray and UV-irradiations

    International Nuclear Information System (INIS)

    Taga, Masataka; Shiraishi, Kazunori; Shimura, Tsutomu; Uematsu, Norio; Kato, Tomohisa; Niwa, Ohtsura; Nishimune, Yoshitake; Aizawa, Shinichi; Oshimura, Mitsuo

    2000-01-01

    The effect of caffeine was studied on the radioresponses of undifferentiated mouse embryonal carcinoma cells (EC cells) with or without the functional p53. The radioresponses studied included radiosensitivity, the activation of p53, apoptosis with characteristic DNA ladder formation and cell cycle progression. An undifferentiated mouse EC cell line, ECA2, and a newly established p53-deficient EC cell line, p53δ, were used in the present study. The status of the p53 gene did not significantly affect the colony survivals of undifferentiated EC cells to X-rays and UV. Although a post-irradiation treatment with caffeine sensitized both lines to X-rays marginally, the sensitization was prominent for UV regardless of the p53 status of the cells. The activation of a p53 responsible lacZ reporter construct was observed in stably transfected ECA2 cells after X-ray and UV irradiations. Caffeine suppressed the X-ray induced activation of the lacZ reporter, while it drastically enhanced the activation after UV irradiation. X-rays and UV readily triggered the apoptosis of ECA2 cells with the characteristic DNA ladder. Although UV-induced DNA ladder formation was enhanced by caffeine, that induced by X-rays was unaffected. Therefore, the effects of caffeine on the p53-dependent radioresponses were found to be agent specific: suppression for the X-ray induced and augmentation for the UV induced. In contrast to p53-proficient ECA2 cells, smear-like DNA degradation was observed for irradiated p53δ cells, suggesting the presence of a mode of cell death without DNA ladder formation. UV induction of the smear-like DNA degradation was enhanced in the presence of caffeine. Regardless of the state of the p53 gene, G1/S arrest was not observed in X-ray and UV irradiated EC cells. X-rays induced G2/M arrest in both lines, which was abrogated by caffeine, while G2/M arrest after UV was unaffected by a caffeine treatment. These results indicate that the radioresponses of undifferentiated

  6. Enhanced expression of extracellular calcium sensing receptor in monocyte-differentiated versus undifferentiated HL-60 cells: potential role in regulation of a nonselective cation channel.

    Science.gov (United States)

    Yamaguchi, T; Ye, C; Chattopadhyay, N; Sanders, J L; Vassilev, P M; Brown, E M

    2000-05-01

    Human promyelocytic leukemia cells (HL-60) have been used widely as a model for studying the differentiation of hematopoietic progenitor cells in vitro. After treatment with phorbol-12-myristate-13-acetate (PMA) or 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], HL-60 cells differentiate into cells with the phenotype of monocytes/macrophages. We previously showed that peripheral blood monocytes and the murine J774 monocytic cell line express the CaR, and myeloid progenitors in the bone marrow and myeloid cells in peripheral blood other than monocytes express lower levels of the CaR. Therefore, we investigated whether undifferentiated HL-60 cells express a functional G protein-coupled, extracellular calcium (Ca(2+)(o))-sensing receptor (CaR) and if the expression of the CaR increases as these cells differentiate along the monocytic lineage. The use of reverse transcription-polymerase chain reaction (RT-PCR) with CaR-specific primers, followed by sequencing of the amplified products, identified an authentic CaR transcript in undifferentiated HL-60 cells. Both immunocytochemistry and Western blot analysis using a CaR-specific antiserum detected low levels of CaR protein expression in undifferentiated HL-60 cells. The levels of CaR protein increased considerably following treatment of the cells with PMA (50 nM) or 1,25(OH)(2)D(3) (100 nM) for 5 days. Northern analysis using a CaR-specific riboprobe identified CaR transcripts in undifferentiated HL-60 cells, but CaR mRNA levels did not change appreciably after treatment with either agent, suggesting that upregulation of CaR protein occurs at a translational level. PMA-treated HL-60 cells expressed a nonselective cation channel (NCC), and the calcimimetic CaR activator, NPS R-467, but not its less active stereoisomer, NPS S-467, as well as the polycationic CaR agonist, neomycin, activated this NCC, demonstrating that the CaR expressed in these cells is functionally active. Therefore, HL-60 cells exhibit an increase in Ca

  7. Petrology, Magnetic susceptibility, Tectonic setting and mineralization associated with Plutonic and Volcanic Rocks, Eastern Bajestan and Taherabad, Iran

    Directory of Open Access Journals (Sweden)

    Malihe Ghoorchi

    2009-09-01

    Full Text Available Study area is located in district of Bajestan and Ferdows cities, NE of Iran. Structurally, this area is part of Lut block. The oldest exposed rocks, to the north of intrusive rocks and in Eastern Bajestan, are meta-chert, slate, quartzite, thin-bedded crystalline limestone and meta-argillite. The sedimentary units are: Sardar Formation (Carboniferous, Jamal Formation (Permian, Sorkh Shale and Shotori Formations (Triassic, carbonateous rocks (Cretaceous and lithostratigraphically equivalent to Kerman conglomerate (Cretaceous-Paleocene are exposed in this area. Based on relative age, magmatism in eastern Bajestan and Taherabad started after Late Cretaceous and it has been active and repeated during Tertiary time. At least, three episodes of volcanic activities are recognized in this area. The first stage was mainly volcanic flow with mafic composition and minor intermediate. The second episode was mainly intermediate in composition. The third stage was changed to acid-intermediate in composition. Since the plutonic rocks intruded the volcanic rocks, therefore they may be Oligo-Miocene age. Bajestan intrusive rocks are granite-granodiorite-quartz monzonite. Taherabad intrusive rocks are diorite-quartz diorite- monzonite-latite. Bajestan intrusive rocks are reduced type (ilmenite series and Taherabad intrusive rocks are oxidized type (magnetite series.Based on geochemical analysis including trace elements, REE and isotopic data, Bajestan intrusive rocks formed in continental collision zone and the magma has crustal origin. Taherabad intrusive rocks were formed in subduction zone and magma originated from oceanic crust. Taherabad intrusive rock has exploration potential for Cu-Au and pb.

  8. The Chronology of Rock Art

    Indian Academy of Sciences (India)

    Such phases are tentatively ascribed to different archaeological cultures on the basis of the contextual availability, stylistic similarities and so on. Ethnographic analogies are also attempted in the dating of rock art .

  9. Rock Art of Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Majeed Khan

    2013-12-01

    Full Text Available It is not only oil in which Saudi Arabia is rich, but it is also among the four richest rock art regions of the world. Hundreds and thousands of petroglyphs, painted rock art, and ancient Arabian inscriptions sites are located all over the country, representing various cultural phases, from the Neolithic until the recent past. One can see the naturalistic, schematic, abstract, mythical, and mystical images representing ancient ideology, thoughts about the metaphysical world, religious entity, economy, environment, human activities, and variety of animal types, according to particular climatic and environmental conditions. The rock art of Saudi Arabia is the mirror of its rich cultural heritage of so-called Bedouin or desert dwellers that surprises the world with its 4000 archaeological and more than 1500 rock art sites.

  10. Chemical methods of rock analysis

    National Research Council Canada - National Science Library

    Jeffery, P. G; Hutchison, D

    1981-01-01

    A practical guide to the methods in general use for the complete analysis of silicate rock material and for the determination of all those elements present in major, minor or trace amounts in silicate...

  11. Discrete Fracture Networks Groundwater Modelling at Bedding Control Fractured Sedimentary Rock mass

    Science.gov (United States)

    Pin, Yeh; Yuan-Chieh, Wu

    2017-04-01

    Groundwater flow modelling in fractured rock mass is an important challenging work in predicting the transport of contamination. So far as we know about the numerical analysis method was consider for crystalline rock, which means discontinuous are treated as stochastic distribution in homogeneous rock mass. Based on the understanding of geology in Taiwan in past few decades, we know that the hydraulic conductivities of Quaternary and Tertiary system rock mass are strongly controlled by development of sedimentary structures (bedding plane). The main purpose of this study is to understand how Discrete Fracture Networks (DFN) affects numerical results in terms of hydraulic behavior using different DFN generation methods. Base on surface geology investigation and core drilling work (3 boreholes with a total length of 120m), small scale fracture properties with in Cho-lan formation (muddy sandstone) are defined, including gently dip of bedding and 2 sub-vertical joint sets. Two FracMan/MAFIC numerical modellings are conducted, using ECPM approach (Equivalent Continuum Porous Media); case A considered all fracture were Power law distribution with Poisson fracture center; case B considered all bedding plans penetrate into modelling region, and remove the bedding count to recalculate joint fracture parameters. Modelling results show that Case B gives stronger groundwater pathways than Case A and have impact on flow field. This preliminary modelling result implicates the groundwater flow modelling work in some fractured sedimentary rock mass, might be considerate to rock sedimentary structure development itself, discontinuous maybe not follow the same stochastic DFN parameter.

  12. Thermally induced rock stress increment and rock reinforcement response

    International Nuclear Information System (INIS)

    Hakala, M.; Stroem, J.; Nujiten, G.; Uotinen, L.; Siren, T.; Suikkanen, J.

    2014-07-01

    This report describes a detailed study of the effect of thermal heating by the spent nuclear fuel containers on the in situ rock stress, any potential rock failure, and associated rock reinforcement strategies for the Olkiluoto underground repository. The modelling approach and input data are presented together repository layout diagrams. The numerical codes used to establish the effects of heating on the in situ stress field are outlined, together with the rock mass parameters, in situ stress values, radiogenic temperatures and reinforcement structures. This is followed by a study of the temperature and stress evolution during the repository's operational period and the effect of the heating on the reinforcement structures. It is found that, during excavation, the maximum principal stress is concentrated at the transition areas where the profile changes and that, due to the heating from the deposition of spent nuclear fuel, the maximum principal stress rises significantly in the tunnel arch area of NW/SW oriented central tunnels. However, it is predicted that the rock's crack damage (CD, short term strength) value of 99 MPa will not be exceeded anywhere within the model. Loads onto the reinforcement structures will come from damaged and loosened rock which is assumed in the modelling as a free rock wedge - but this is very much a worst case scenario because there is no guarantee that rock cracking would form a free rock block. The structural capacity of the reinforcement structures is described and it is predicted that the current quantity of the rock reinforcement is strong enough to provide a stable tunnel opening during the peak of the long term stress state, with damage predicted on the sprayed concrete liner. However, the long term stability and safety can be improved through the implementation of the principles of the Observational Method. The effect of ventilation is also considered and an additional study of the radiogenic heating effect on the brittle

  13. Missed injury and the tertiary trauma survey.

    Science.gov (United States)

    Thomson, Charles B; Greaves, Ian

    2008-01-01

    Missed injury in the context of major trauma remains a persistent problem, both from a clinical and medico-legal point-of-view. Estimates of the incidence vary widely, dependent on the precise parameters of the studied population, the definition of missed injury and the extent of follow-up, but may be as high as 38%. The tertiary survey, in which formal repeated examination of the patient is undertaken after initial resuscitation and treatment have taken place, has been suggested as a way of identifying injuries not found at presentation. This paper appraises the concept of the tertiary survey, and also reviews the literature on missed injury in order to identify the risk factors, the types of injury and the reasons for error.

  14. Alcohol consumption in tertiary education students

    Directory of Open Access Journals (Sweden)

    Reavley Nicola J

    2011-07-01

    Full Text Available Abstract Background Heavy alcohol consumption among adolescents and young adults is an issue of significant public concern. With approximately 50% of young people aged 18-24 attending tertiary education, there is an opportunity within these settings to implement programs that target risky drinking. The aim of the current study was to survey students and staff within a tertiary education institution to investigate patterns of alcohol use, alcohol-related problems, knowledge of current National Health and Medical Research Council (NHMRC guidelines for alcohol consumption and intentions to seek help for alcohol problems. Methods Students of an Australian metropolitan university (with staff as a comparison group participated in a telephone interview. Questions related to knowledge of NHMRC guidelines, drinking behaviour, alcohol-related problems and help-seeking intentions for alcohol problems. Level of psychological distress was also assessed. Results Of the completed interviews, 774 (65% were students and 422 (35% were staff. While staff were more likely to drink regularly, students were more likely to drink heavily. Alcohol consumption was significantly higher in students, in males and in those with a history of earlier onset drinking. In most cases, alcohol-related problems were more likely to occur in students. The majority of students and staff had accurate knowledge of the current NHMRC guidelines, but this was not associated with lower levels of risky drinking. Psychological distress was associated with patterns of risky drinking in students. Conclusions Our findings are consistent with previous studies of tertiary student populations, and highlight the disconnect between knowledge of relevant guidelines and actual behaviour. There is a clear need for interventions within tertiary education institutions that promote more effective means of coping with psychological distress and improve help-seeking for alcohol problems, particularly among

  15. Tertiary lymphoid organs in Takayasu Arteritis

    OpenAIRE

    Marc eClement; Marc eClement; Adrien eGaly; Patrick eBruneval; Marion eMorvan; Fabien eHyafil; Fabien eHyafil; Khadija eBenali; Nicoletta ePasi; Lydia eDeschamps; Quentin ePellenc; Quentin ePellenc; Thomas ePapo; Antonino eNicoletti; Antonino eNicoletti

    2016-01-01

    Objective: The role of B cells in the pathogenesis of Takayasu arteritis (TA) is controversial. We aimed to study the presence of tertiary lymphoid organs (TLOs) in the aortic wall of TA patients.Methods: Hematoxylin and eosin–stained sections from aorta specimens from patients with TA were screened for TLOs. The presence of B cell aggregates (CD20), follicular dendritic cells (FDCs, CD21), and high endothelial venules (HEVs, PNAd) was investigated by immunohistochemistry. Immune cells from t...

  16. Tertiary Lymphoid Organs in Takayasu Arteritis

    OpenAIRE

    Clement, Marc; Galy, Adrien; Bruneval, Patrick; Morvan, Marion; Hyafil, Fabien; Benali, Khadija; Pasi, Nicoletta; Deschamps, Lydia; Pellenc, Quentin; Papo, Thomas; Nicoletti, Antonino; Sacre, Karim

    2016-01-01

    Objective The role of B cells in the pathogenesis of Takayasu arteritis (TA) is controversial. We aimed to study the presence of tertiary lymphoid organs (TLOs) in the aortic wall of TA patients. Methods Hematoxylin and eosin-stained sections from aorta specimens from patients with TA were screened for TLOs. The presence of B cell aggregates (CD20), follicular dendritic cells (FDCs, CD21), and high endothelial venules (HEVs, PNAd) was investigated by immunohistochemistry. Immune ce...

  17. Optimising Tertiary Student Accommodation within University Neighbourhoods

    OpenAIRE

    Ike, Nnenna; Baldwin, Claudia; Lathouras, Athena

    2017-01-01

    Tertiary students’ activities within neighbourhoods adjacent to universities engender positive and negative impacts that have consequences for neighbourhood sustainability. This might lead to studentification, a process that triggers physical, economic and socio-cultural transformation of university towns. Where non-student residents perceive negative impacts, it can lead to conflict and resentment towards the student population, mistrust between student and local resident groups and a decrea...

  18. Outcomes of the treatment of head and neck sarcomas in a tertiary referral center

    Directory of Open Access Journals (Sweden)

    Andrew eLindford

    2015-05-01

    Full Text Available Head and neck sarcomas are a rare and heterogeneous group of tumors that pose management challenges. We report our experience with these tumors. Forty consecutive patients treated for 44 head and neck sarcomas between 1997 and 2014 were culled from our prospectively maintained head and neck database. Five patients were excluded. The adult cohort consisted 29 (83% patients of a mean age of 57.7 years, with 33 sarcomas. The most common diagnoses were undifferentiated pleomorphic sarcoma (27% and chondroblastic osteosarcoma (21%. Clear surgical margins were achieved in 24/33 (73% lesions. Twenty-two patients received radiotherapy and/or chemotherapy. Fourteen patients developed local (n=6, regional (n=1 and distant (n=7 recurrence. The overall 5-year survival was 66% with a mean survival interval of 66.5 months. Recurrent sarcoma, close (<1mm or involved surgical margins and advanced age were associated with statistically significantly reduced survival. The pediatric cohort consisted 6 (17% patients, with a mean age of nine years. Five patients had primary embryonal rhabdomyosarcomas and one had chondroblastic osteosarcoma. Clear surgical margins were achieved in 5 (83% patients. All patients received adjuvant radiotherapy and/or chemotherapy. Mean survival interval was 102 months. Three patients developed local (n=1 or distant (n=2 recurrence. Twenty-three free and 8 pedicled flaps were performed in 25 patients. 11/39 (28% lesions in 11 patients developed a complication. In conclusion, head and neck sarcomas are best managed by a multidisciplinary team at a tertiary head and neck referral centre and resection with clear margins is vital for disease control.

  19. Seismic response of rock joints and jointed rock mass

    International Nuclear Information System (INIS)

    Ghosh, A.; Hsiung, S.M.; Chowdhury, A.H.

    1996-06-01

    Long-term stability of emplacement drifts and potential near-field fluid flow resulting from coupled effects are among the concerns for safe disposal of high-level nuclear waste (HLW). A number of factors can induce drift instability or change the near-field flow patterns. Repetitive seismic loads from earthquakes and thermal loads generated by the decay of emplaced waste are two significant factors. One of two key technical uncertainties (KTU) that can potentially pose a high risk of noncompliance with the performance objectives of 10 CFR Part 60 is the prediction of thermal-mechanical (including repetitive seismic load) effects on stability of emplacement drifts and the engineered barrier system. The second KTU of concern is the prediction of thermal-mechanical-hydrological (including repetitive seismic load) effects on the host rock surrounding the engineered barrier system. The Rock Mechanics research project being conducted at the Center for Nuclear Waste Regulatory Analyses (CNWRA) is intended to address certain specific technical issues associated with these two KTUs. This research project has two major components: (i) seismic response of rock joints and a jointed rock mass and (ii) coupled thermal-mechanical-hydrological (TMH) response of a jointed rock mass surrounding the engineered barrier system (EBS). This final report summarizes the research activities concerned with the repetitive seismic load aspect of both these KTUs

  20. Evaluation of Rock Bolt Support for Polish Hard Rock Mines

    Science.gov (United States)

    Skrzypkowski, Krzysztof

    2018-03-01

    The article presents different types of rock bolt support used in Polish ore mining. Individual point resin and expansion rock bolt support were characterized. The roof classes for zinc and lead and copper ore mines were presented. Furthermore, in the article laboratory tests of point resin rock bolt support in a geometric scale of 1:1 with minimal fixing length of 0.6 m were made. Static testing of point resin rock bolt support were carried out on a laboratory test facility of Department of Underground Mining which simulate mine conditions for Polish ore and hard coal mining. Laboratory tests of point resin bolts were carried out, especially for the ZGH Bolesław, zinc and lead "Olkusz - Pomorzany" mine. The primary aim of the research was to check whether at the anchoring point length of 0.6 m by means of one and a half resin cartridge, the type bolt "Olkusz - 20A" is able to overcome the load.The second purpose of the study was to obtain load - displacement characteristic with determination of the elastic and plastic range of the bolt. For the best simulation of mine conditions the station steel cylinders with an external diameter of 0.1 m and a length of 0.6 m with a core of rock from the roof of the underground excavations were used.

  1. 30 CFR 57.3461 - Rock bursts.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Rock bursts. 57.3461 Section 57.3461 Mineral...-Underground Only § 57.3461 Rock bursts. (a) Operators of mines which have experienced a rock burst shall— (1) Within twenty four hours report to the nearest MSHA office each rock burst which: (i) Causes persons to...

  2. 30 CFR 75.402 - Rock dusting.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Rock dusting. 75.402 Section 75.402 Mineral... SAFETY STANDARDS-UNDERGROUND COAL MINES Combustible Materials and Rock Dusting § 75.402 Rock dusting... or too high in incombustible content to propagate an explosion, shall be rock dusted to within 40...

  3. A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma.

    Science.gov (United States)

    Maekawa, Naoya; Konnai, Satoru; Takagi, Satoshi; Kagawa, Yumiko; Okagawa, Tomohiro; Nishimori, Asami; Ikebuchi, Ryoyo; Izumi, Yusuke; Deguchi, Tatsuya; Nakajima, Chie; Kato, Yukinari; Yamamoto, Keiichi; Uemura, Hidetoshi; Suzuki, Yasuhiko; Murata, Shiro; Ohashi, Kazuhiko

    2017-08-21

    Immunotherapy targeting immune checkpoint molecules, programmed cell death 1 (PD-1) and PD-ligand 1 (PD-L1), using therapeutic antibodies has been widely used for some human malignancies in the last 5 years. A costimulatory receptor, PD-1, is expressed on T cells and suppresses effector functions when it binds to its ligand, PD-L1. Aberrant PD-L1 expression is reported in various human cancers and is considered an immune escape mechanism. Antibodies blocking the PD-1/PD-L1 axis induce antitumour responses in patients with malignant melanoma and other cancers. In dogs, no such clinical studies have been performed to date because of the lack of therapeutic antibodies that can be used in dogs. In this study, the immunomodulatory effects of c4G12, a canine-chimerised anti-PD-L1 monoclonal antibody, were evaluated in vitro, demonstrating significantly enhanced cytokine production and proliferation of dog peripheral blood mononuclear cells. A pilot clinical study was performed on seven dogs with oral malignant melanoma (OMM) and two with undifferentiated sarcoma. Objective antitumour responses were observed in one dog with OMM (14.3%, 1/7) and one with undifferentiated sarcoma (50.0%, 1/2) when c4G12 was given at 2 or 5 mg/kg, every 2 weeks. c4G12 could be a safe and effective treatment option for canine cancers.

  4. Current status of crushed rock and whole rock column studies

    International Nuclear Information System (INIS)

    Vine, E.N.; Daniels, W.R.; Rundberg, R.S.; Thompson, J.L.

    1980-01-01

    Measurements on a large number of crushed rock columns of tuff, granite, and argillite are discussed. The isotopes 85 Sr, 137 Cs, 133 Ba, 141 Ce, 152 Eu, /sup 95m/Tc, and 233 U were used. Flow rates were varied from approx. 30 to approx. 30000 m/y. Other parameters studied include isotope concentration and atmosphere. The sorption ratios calculated were compared with batch sorption ratios on the same samples. Methods of studying the movement of radionuclides through whole rock cores are described. The problems associated with sealing the cores to prevent leaking along the exterior surface and one possible solution are discussed. The strontium sorption ratio obtained by elution of one solid tuff core is compared with the batch and crushed rock column sorption ratios

  5. Review of and contribution to the Stratigraphy of the Cenozoic Igneous Rocks in the Republic of Yemen

    International Nuclear Information System (INIS)

    El-Nakhal, H.A.

    2002-01-01

    In Yemen the Cenozoic igneous rocks consists of intrusive and extrusive rocks with interlayered sediments, all of which are included within the Manakha Group (latest Cretaceous-Holocene). This group is subdivided into the Haraz Formation which includes the latest Cretaceous-Tertiary volcanics and the interlayered sediments, the Aden Formation which includes the Late Tertiary-Holocene volcanics, and the Bura Formations are introduced here as new units. The Haraz Formation replaces the informal names: Trap Series, Yemen Volcanics and Aden Trap Series, Yemen Volcanics and Adan Trap Series.The Adan Formation are a readaptation of the term Aden Vocanic Series. A startotype for the Aden Formation is designated in the Shuqra-Ahwar area. (author)

  6. Interaction between Fingering and Heterogeneity during Viscous Oil Recovery in Carbonate Rocks (Invited)

    Science.gov (United States)

    Mohanty, K. K.; Doorwar, S.

    2013-12-01

    Due to the fast depleting conventional oil reserves, research in the field of petroleum engineering has shifted focus towards unconventional (viscous and heavy) oils. Many of the viscous oil reserves are in carbonate rocks. Thermal methods in carbonate formations are complicated by mineral dissolution and precipitation. Non-thermal methods should be developed for viscous oils in carbonates. In viscous oil reservoirs, oil recovery due to water flood is low due to viscous fingering. Polymer flood is an attractive process, but the timing of the polymer flood start is an important parameter in the optimization of polymer floods. Vuggy Silurian dolomite cores were saturated with formation brine and reservoir oil (150-200 cp). They were then displaced by either a polymeric solution (secondary polymer flood) or brine followed the polymeric solution (tertiary polymer flood). The amount of brine injection was varied as a parameter. Oil recovery and pressure drop was monitored as a function of the starting point of the polymer flood. To visualize the displacement at the pore-scale, two types of micromodels were prepared: one with isolated heterogeneity and the other with connected heterogeneity. The wettability of the micromodels was either water-wet or oil-wet. The micromodels were saturated with formation brine and oil. A series of water flood and polymer flood was conducted to identify the mechanism of fluid flow. Dolomite corefloods show that a tertiary polymer flood following a secondary water flood recovers a substantial amount of oil unlike what is observed in typical sandstone cores with light oil. The tertiary oil recovery plus the secondary waterflood recovery can exceed the oil recovery in a secondary polymer flood in dolomite-viscous oil-brine system. These experiments were repeated in a Berea-oil-brine system which showed that the oil recovered in the secondary polymer flood was similar to the cumulative oil recovery in the tertiary polymer flood. The high

  7. Rock Pore Structure as Main Reason of Rock Deterioration

    Directory of Open Access Journals (Sweden)

    Ondrášik Martin

    2014-03-01

    Full Text Available Crashed or dimensional rocks have been used as natural construction material, decoration stone or as material for artistic sculptures. Especially old historical towns not only in Slovakia have had experiences with use of stones for construction purposes for centuries. The whole buildings were made from dimensional stone, like sandstone, limestone or rhyolite. Pavements were made especially from basalt, andesite, rhyolite or granite. Also the most common modern construction material - concrete includes large amounts of crashed rock, especially limestone, dolostone and andesite.

  8. Fracture characteristics in Japanese rock

    International Nuclear Information System (INIS)

    Ijiri, Yuji; Sawada, Atsushi; Akahori, Kuniaki

    1999-11-01

    It is crucial for the performance assessment of geosphere to evaluate the characteristics of fractures that can be dominant radionuclide migration pathways from a repository to biosphere. This report summarizes the characteristics of fractures obtained from broad literature surveys and the fields surveys at the Kamaishi mine in northern Japan and at outcrops and galleries throughout the country. The characteristics of fractures described in this report are fracture orientation, fracture shape, fracture frequency, fracture distribution in space, transmissivity of fracture, fracture aperture, fracture fillings, alteration halo along fracture, flow-wetted surface area in fracture, and the correlation among these characteristics. Since granitic rock is considered the archetype fractured media, a large amount of fracture data is available in literature. In addition, granitic rock has been treated as a potential host rock in many overseas programs, and has JNC performed a number of field observations and experiments in granodiorite at the Kamaishi mine. Therefore, the characteristics of fractures in granitic rock are qualitatively and quantitatively clarified to some extent in this report, while the characteristics of fractures in another rock types are not clarified. (author)

  9. Hot dry rock heat mining

    International Nuclear Information System (INIS)

    Duchane, D.V.

    1992-01-01

    Geothermal energy utilizing fluids from natural sources is currently exploited on a commercial scale at sites around the world. A much greater geothermal resource exists, however, in the form of hot rock at depth which is essentially dry. This hot dry rock (HDR) resource is found almost everywhere, but the depth at which usefully high temperatures are reached varies from place to place. The technology to mine the thermal energy from HDR has been under development for a number of years. Using techniques adapted from the petroleum industry, water is pumped at high pressure down an injection well to a region of usefully hot rock. The pressure forces open natural joints to form a reservoir consisting of a small amount of water dispensed in a large volume of hot rock. This reservoir is tapped by second well located at some distance from the first, and the heated water is brought to the surface where its thermal energy is extracted. The same water is then recirculated to mine more heat. Economic studies have indicated that it may be possible to produce electricity at competitive prices today in regions where hot rock is found relatively close to the surface

  10. Rock-type control on erosion-induced uplift, eastern Swiss Alps

    Science.gov (United States)

    Korup, Oliver; Schlunegger, Fritz

    2009-02-01

    There is growing evidence that Quaternary rock uplift in parts of the European Alps is a consequence of climate- and erosion-driven isostatic rebound. Contemporary rates of rock uplift U in the Swiss Alps show two distinctive dome-like peak regions that attain ~ 1.6 mm yr - 1 . We focus on the Alpenrhein catchment and its surroundings, where one of these peak regions spatially coincides with widely exposed Cretaceous Bündner schist and lower Tertiary flysch. Field assessments and analyses of hillslope gradient distributions quantitatively demonstrate the low rock-mass strength and high erodibility of these rocks. This is reflected in mean postglacial catchment erosion rates D ~ 4 mm yr - 1 , as opposed to 0.7 mm yr - 1 in more resistant crystalline rocks. Though largely inferred from landslide- and debris-flow prone tributary catchments export, from the region. We further find that the steepness of bedrock rivers, the density of large landslides, and D correlate with the highest values of U. Our observations highlight the possibility that erosion of mechanically weak Bündner schist and flysch enhanced by large landslides may have contributed to regional crustal unloading, and concomitant rock uplift. Irrespective of whether this is betraying a coupling between long-term uplift and erosion modulated by rock type, our findings indicate that long-term (10 3 to 10 4 yr) geomorphic signals contained in bedrock-river steepness, spatial density of large landslides, and postglacial erosion rates strikingly correlate with regional gradients of historic (10 1 yr) rock uplift rates.

  11. Thermal expansion of granite rocks

    International Nuclear Information System (INIS)

    Stephansson, O.

    1978-04-01

    The thermal expansion of rocks is strongly controlled by the thermal expansion of the minerals. The theoretical thermal expansion of the Stripa Granite is gound to be 21 . 10 -6 [deg C] -1 at 25 deg C and 38 . 10 -6 [deg C] -1 at 400 deg C. The difference in expansion for the rock forming minerals causes micro cracking at heating. The expansion due to micro cracks is found to be of the same order as the mineral expansion. Most of the micro cracks will close at pressures of the order of 10 - 20 MPa. The thermal expansion of a rock mass including the effect of joints is determined in the pilot heater test in the Stripa Mine

  12. Uranium endowments in phosphate rock

    Energy Technology Data Exchange (ETDEWEB)

    Ulrich, Andrea E., E-mail: andrea.ulrich@env.ethz.ch [Institute for Environmental Decisions (IED), Natural and Social Science Interface, ETH Zurich Universitässtrasse 22, 8092 Zurich (Switzerland); Institute for Agricultural Sciences, Plant Nutrition, ETH Zurich, Eschikon 33, 8315 Lindau (Switzerland); Schnug, Ewald, E-mail: e.schnug@tu-braunschweig.de [Department of Life Sciences, Technical University of Braunschweig, Pockelsstraße 14, D-38106 Braunschweig (Germany); Prasser, Horst-Michael, E-mail: prasser@lke.mavt.ethz.ch [Institute of Energy Technology, Laboratory of Nuclear Energy Systems, ETH Zurich, Sonneggstrasse 3, 8092 Zurich (Switzerland); Frossard, Emmanuel, E-mail: emmanuel.frossard@usys.ethz.ch [Institute for Agricultural Sciences, Plant Nutrition, ETH Zurich, Eschikon 33, 8315 Lindau (Switzerland)

    2014-04-01

    This study seeks to identify and specify the components that make up the prospects of U recovery from phosphate rock. A systems approach is taken. The assessment includes i) reviewing past recovery experience and lessons learned; ii) identifying factors that determine recovery; and iii) establishing a contemporary evaluation of U endowments in phosphate rock reserves, as well as the available and recoverable amounts from phosphate rock and phosphoric acid production. We find that in the past, recovery did not fulfill its potential and that the breakup of the Soviet Union worsened then-favorable recovery market conditions in the 1990s. We find that an estimated 5.7 million tU may be recoverable from phosphate rock reserves. In 2010, the recoverable tU from phosphate rock and phosphoric acid production may have been 15,000 tU and 11,000 tU, respectively. This could have filled the world U supply-demand gap for nuclear energy production. The results suggest that the U.S., Morocco, Tunisia, and Russia would be particularly well-suited to recover U, taking infrastructural considerations into account. We demonstrate future research needs, as well as sustainability orientations. We conclude that in order to promote investment and production, it seems necessary to establish long-term contracts at guaranteed prices, ensuring profitability for phosphoric acid producers. - Highlights: • We identify components that underlie the recovery of uranium from phosphate rock. • We estimate that 11,000 tU may have been recoverable from phosphoric acid in 2010. • Recovery is a resource conservation and environmental pollution control strategy. • To ensure investment in recovery technology, profitability needs to be secured.

  13. Uranium deposits in granitic rocks

    International Nuclear Information System (INIS)

    Nishimori, R.K.; Ragland, P.C.; Rogers, J.J.W.; Greenberg, J.K.

    1977-01-01

    This report is a review of published data bearing on the geology and origin of uranium deposits in granitic, pegmatitic and migmatitic rocks with the aim of assisting in the development of predictive criteria for the search for similar deposits in the U.S. Efforts were concentrated on the so-called ''porphyry'' uranium deposits. Two types of uranium deposits are primarily considered: deposits in pegmatites and alaskites in gneiss terrains, and disseminations of uranium in high-level granites. In Chapter 1 of this report, the general data on the distribution of uranium in igneous and metamorphic rocks are reviewed. Chapter 2 contains some comments on the classification of uranium deposits associated with igneous rocks and a summary of the main features of the geology of uranium deposits in granites. General concepts of the behavior of uranium in granites during crustal evolution are reviewed in Chapter 3. Also included is a discussion of the relationship of uranium mineralization in granites to the general evolution of mobile belts, plus the influence of magmatic and post-magmatic processes on the distribution of uranium in igneous rocks and related ore deposits. Chapter 4 relates the results of experimental studies on the crystallization of granites to some of the geologic features of uranium deposits in pegmatites and alaskites in high-grade metamorphic terrains. Potential or favorable areas for igneous uranium deposits in the U.S.A. are delineated in Chapter 5. Data on the geology of specific uranium deposits in granitic rocks are contained in Appendix 1. A compilation of igneous rock formations containing greater than 10 ppM uranium is included in Appendix 2. Appendix 3 is a report on the results of a visit to the Roessing area. Appendix 4 is a report on a field excursion to eastern Canada

  14. Nonlinear Creep Model for Deep Rock under High Stress and High Pore Water Pressure Condition

    Directory of Open Access Journals (Sweden)

    Xie Yuanguang

    2016-05-01

    Full Text Available Conventional triaxial compression creep experiments for deep sandstone under high confining pressure and high pore water pressure were carried out, in order to predict the creep response of deep rock under these conditions. A nonlinear viscoelastic-plastic creep constitutive model was proposed based on the experimental results. The theory of component model was used as a basis for the formulation of this model. First, by using mathematical fitting and analogy, a new nonlinear viscous component was introduced based on the properties of the creep curves during the tertiary stage. Second, a timer component to judge whether the creep can get into the tertiary stage was presented. Finally, a nonlinear creep model was proposed. Results showed good agreement between theory curves from the nonlinear creep model and experimental data. This model can be applied to predict deep rock creep responses under high stress and high pore water pressure conditions. Hence, the obtained conclusions in this study are beneficial to deep rock engineering.

  15. 20020732: Rock (14), panel (21)

    OpenAIRE

    None

    2002-01-01

    Rock Art photograph, (21); Element broken off much larger rock. [cam element='coordinate' qualifier='longitude']W 70deg34'55.5"[/cam][cam element='coordinate' qualifier='latitude']S 32deg49'48.8"[/cam][cam element='coordinate' qualifier='altitude']913[/cam][cam element='coordinate' qualifier='bearing']0[/cam][cam element='coordinate' qualifier='inclination']55[/cam][cam element='coordinate' qualifier='cartesian'](3.000,1.100,2.500)[/cam

  16. Some rock mass assessment procedures for discontinuous crystalline rock

    International Nuclear Information System (INIS)

    Boodt, P.I.; Brown, E.T.

    1985-03-01

    Underground radioactive waste repositories place especially stringent demands on rock mass assessment and excavation design methodologies. As part of the Building Research Establishment's programme of research into geotechnical site assessment methodology, experiments were undertaken at an underground test site in granite at Troon, Cornwall, and in the Imperial College Laboratories. The results of discontinuity surveys showed that the borehole impression packer probe technique can provide an important source of information for radioactive waste repository site assessment. Similarly, borehole pressure tests can provide valuable data on discontinuity apertures and hydraulic conductivities and on rock mass permeabilities. A versatile, modular borehole pressure test system for use from restricted underground locations was developed and used successfully. Field tests gave values of equivalent parallel plate apertures and discontinuity hydraulic conductivities in similar ranges to those measured in laboratory tests on samples recovered from the site. Discontinuity normal stiffnesses were also measured successfully using the Terra Tek Geothermal Rock Mechanics Test System which proved itself capable of providing laboratory test data required to support geotechnical site assessment procedures for radioactive waste repositories in discontinuous rock. (author)

  17. Uranium occurrence in major rock types by fission-track mapping

    International Nuclear Information System (INIS)

    Ledger, E.G.; Bomber, B.J.; Schaftenaar, W.E.; Tieh, T.T.

    1984-01-01

    Microscopic occurrence of uranium has been determined in about 50 igneous rocks from various location, and in a genetically unrelated sandstone from south Texas. Precambrian granites from the Llano uplift of central Texas contain from a few ppm uranium (considered normal) to over 100 ppm on a whole-rock basis. In granite, uranium is concentrated in: (1) accessory minerals including zircon, biotite, allanite, Fe-Ti oxides, and altered sphene, (2) along grain boundaries and in microfractures by precipitation from deuteric fluids, and (3) as point sources (small inclusions) in quartz and feldspars. Tertiary volcanic rocks from the Davis Mountains of west Texas include diverse rock types from basalt to rhyolite. Average uranium contents increase from 1 ppm in basalts to 7 ppm in rhyolites. Concentration occurs: (1) in iron-titanium-oxides, zircon, and rutile, (2) in the fine-grained groundmass as uniform and point-source concentrations, and (3) as late uranium in cavities associated with banded, silica-rich material. Uranium in ore-grade sandstone is concentrated to more than 3%. Specific occurrences include (1) leucoxene and/or anatase, (2) opaline and calcite cements, (3) mud clasts and altered volcanic rock fragments, and (4) in a few samples, as silt-size uranium- and molybdenum-rich spheres. Uranium content is quite low in pyrite, marcasite, and zeolites

  18. Los abuelos de nuestro rock

    OpenAIRE

    Jacobo Celnik

    2016-01-01

    Los Yetis. Una bomba atómica a go go. La historia de los abuelos de nuestro rock. Diego Londoño; Pulso & Letra Editores, Instituto para el Desarrollo de Antioquia, Instituto de Cultura y Patrimonio de Antioquia, 2014, 98 págs., fotografías.

  19. Simulation of rock deformation behavior

    Directory of Open Access Journals (Sweden)

    Я. И. Рудаев

    2016-12-01

    Full Text Available A task of simulating the deformation behavior of geomaterials under compression with account of over-extreme branch has been addressed. The physical nature of rock properties variability as initially inhomogeneous material is explained by superposition of deformation and structural transformations of evolutionary type within open nonequilibrium systems. Due to this the description of deformation and failure of rock is related to hierarchy of instabilities within the system being far from thermodynamic equilibrium. It is generally recognized, that the energy function of the current stress-strain state is a superposition of potential component and disturbance, which includes the imperfection parameter accounting for defects not only existing in the initial state, but also appearing under load. The equation of state has been obtained by minimizing the energy function by the order parameter. The imperfection parameter is expressed through the strength deterioration, which is viewed as the internal parameter of state. The evolution of strength deterioration has been studied with the help of Fokker – Planck equation, which steady form corresponds to rock statical stressing. Here the diffusion coefficient is assumed to be constant, while the function reflecting internal sliding and loosening of the geomaterials is assumed as an antigradient of elementary integration catastrophe. Thus the equation of state is supplemented with a correlation establishing relationship between parameters of imperfection and strength deterioration. While deformation process is identified with the change of dissipative media, coupled with irreversible structural fluctuations. Theoretical studies are proven with experimental data obtained by subjecting certain rock specimens to compression.

  20. Los abuelos de nuestro rock

    Directory of Open Access Journals (Sweden)

    Jacobo Celnik

    2016-12-01

    Full Text Available Los Yetis. Una bomba atómica a go go. La historia de los abuelos de nuestro rock. Diego Londoño; Pulso & Letra Editores, Instituto para el Desarrollo de Antioquia, Instituto de Cultura y Patrimonio de Antioquia, 2014, 98 págs., fotografías.

  1. TrkAIII Promotes Microtubule Nucleation and Assembly at the Centrosome in SH-SY5Y Neuroblastoma Cells, Contributing to an Undifferentiated Anaplastic Phenotype

    Science.gov (United States)

    Farina, Antonietta R.; Di Ianni, Natalia; Cappabianca, Lucia; Ruggeri, Pierdomenico; Ragone, Marzia; Ianni, Giulia; Gulino, Alberto; Mackay, Andrew R.

    2013-01-01

    The alternative TrkAIII splice variant is expressed by advanced stage human neuroblastomas (NBs) and exhibits oncogenic activity in NB models. In the present study, employing stable transfected cell lines and assays of indirect immunofluorescence, immunoprecipitation, Western blotting, microtubule regrowth, tubulin kinase, and tubulin polymerisation, we report that TrkAIII binds α-tubulin and promotes MT nucleation and assembly at the centrosome. This effect depends upon spontaneous TrkAIII activity, TrkAIII localisation to the centrosome and pericentrosomal area, and the capacity of TrkAIII to bind, phosphorylate, and polymerise tubulin. We propose that this novel role for TrkAIII contributes to MT involvement in the promotion and maintenance of an undifferentiated anaplastic NB cell morphology by restricting and augmenting MT nucleation and assembly at the centrosomal MTOC. PMID:23841091

  2. A comparison of florfenicol-flunixin meglumine versus tulathromycin for the treatment of undifferentiated fever in fall-placed feedlot calves.

    Science.gov (United States)

    Van Donkersgoed, Joyce; Berg, Janice; Hendrick, Steven

    2009-01-01

    The purpose of this study was to compare the efficacy of a new combination drug, florfenicol-flunixin meglumine, with tulathromycin for initial treatment of undifferentiated fever (UF) in fall-placed calves that received metaphylactic tilmicosin on arrival at the feedlot. No significant differences were observed in UF relapses between the two drugs. Calves treated with florfenicol-flunixin had a lower crude case fatality rate (P = .0447) than calves treated with tulathromycin but did not have a significantly lower respiratory disease and histophilosis case fatality rate (P = .12). Whether the new florfenicol-flunixin product is more cost-effective than tulathromycin for the treatment of UF in fall-placed feedlot calves will depend on how the new product is priced in the marketplace relative to tulathromycin.

  3. TrkAIII Promotes Microtubule Nucleation and Assembly at the Centrosome in SH-SY5Y Neuroblastoma Cells, Contributing to an Undifferentiated Anaplastic Phenotype

    Directory of Open Access Journals (Sweden)

    Antonietta R. Farina

    2013-01-01

    Full Text Available The alternative TrkAIII splice variant is expressed by advanced stage human neuroblastomas (NBs and exhibits oncogenic activity in NB models. In the present study, employing stable transfected cell lines and assays of indirect immunofluorescence, immunoprecipitation, Western blotting, microtubule regrowth, tubulin kinase, and tubulin polymerisation, we report that TrkAIII binds α-tubulin and promotes MT nucleation and assembly at the centrosome. This effect depends upon spontaneous TrkAIII activity, TrkAIII localisation to the centrosome and pericentrosomal area, and the capacity of TrkAIII to bind, phosphorylate, and polymerise tubulin. We propose that this novel role for TrkAIII contributes to MT involvement in the promotion and maintenance of an undifferentiated anaplastic NB cell morphology by restricting and augmenting MT nucleation and assembly at the centrosomal MTOC.

  4. Impact of copper oxide nanomaterials on differentiated and undifferentiated Caco-2 intestinal epithelial cells; assessment of cytotoxicity, barrier integrity, cytokine production and nanomaterial penetration.

    Science.gov (United States)

    Ude, Victor C; Brown, David M; Viale, Luca; Kanase, Nilesh; Stone, Vicki; Johnston, Helinor J

    2017-08-23

    Copper oxide nanomaterials (CuO NMs) are exploited in a diverse array of products including antimicrobials, inks, cosmetics, textiles and food contact materials. There is therefore a need to assess the toxicity of CuO NMs to the gastrointestinal (GI) tract since exposure could occur via direct oral ingestion, mucocillary clearance (following inhalation) or hand to mouth contact. Undifferentiated Caco-2 intestinal cells were exposed to CuO NMs (10 nm) at concentrations ranging from 0.37 to 78.13 μg/cm 2 Cu (equivalent to 1.95 to 250 μg/ml) and cell viability assessed 24 h post exposure using the alamar blue assay. The benchmark dose (BMD 20), determined using PROAST software, was identified as 4.44 μg/cm 2 for CuO NMs, and 4.25 μg/cm 2 for copper sulphate (CuSO 4 ), which informed the selection of concentrations for further studies. The differentiation status of cells and the impact of CuO NMs and CuSO 4 on the integrity of the differentiated Caco-2 cell monolayer were assessed by measurement of trans-epithelial electrical resistance (TEER), staining for Zonula occludens-1 (ZO-1) and imaging of cell morphology using scanning electron microscopy (SEM). The impact of CuO NMs and CuSO 4 on the viability of differentiated cells was performed via assessment of cell number (DAPI staining), and visualisation of cell morphology (light microscopy). Interleukin-8 (IL-8) production by undifferentiated and differentiated Caco-2 cells following exposure to CuO NMs and CuSO 4 was determined using an ELISA. The copper concentration in the cell lysate, apical and basolateral compartments were measured with Inductive Coupled Plasma Optical Emission Spectrometry (ICP-OES) and used to calculate the apparent permeability coefficient (P app ); a measure of barrier permeability to CuO NMs. For all experiments, CuSO 4 was used as an ionic control. CuO NMs and CuSO 4 caused a concentration dependent decrease in cell viability in undifferentiated cells. CuO NMs and CuSO 4

  5. The effect of comedication with conventional synthetic disease modifying antirheumatic drugs on TNF inhibitor drug survival in patients with ankylosing spondylitis and undifferentiated spondyloarthritis

    DEFF Research Database (Denmark)

    Lie, Elisabeth; Kristensen, Lars Erik; Forsblad-d'Elia, Helena

    2015-01-01

    OBJECTIVE: To assess the effect of comedication with conventional synthetic disease modifying antirheumatic drugs (csDMARDs) on retention to tumour necrosis factor inhibitor (TNFi) therapy in patients with ankylosing spondylitis (AS) and undifferentiated spondyloarthritis (uSpA). METHODS: Data...... on patients with a clinical diagnosis of AS or uSpA starting treatment with adalimumab, etanercept or infliximab as their first TNFi during 2003-2010 were retrieved from the Swedish national biologics register and linked to national population based registers. Five-year drug survival was analysed by Cox...... regression with age, sex, baseline csDMARD comedication, TNFi type, prescription year and covariates representing frailty and socioeconomic status. AS and uSpA were analysed separately. Sensitivity analyses included models with csDMARD as a time-dependent covariate and adjustments for additional potential...

  6. The state of «the pituitary gland - thyroid gland system» in the young men with undifferentiated dysplasia of the connective tissue

    Directory of Open Access Journals (Sweden)

    P. A. Yurchenko

    2013-01-01

    Full Text Available To investigate the state of «the pituitary gland-thyroid gland system» in the patients with undifferentiated dysplasia of the connective tissue (UDCT 83 young men of the call up age (18.2±0.4 y.o. were examined. The control group consisted of 26 practically healthy young men of the same age (18.5±0.2 y.o.. Autoimmune thyroiditis (AIT was diagnosed in 32.5 % of the men with UDCT. The rate of the internal (visceral phenotypical signs of UDCT in this group was significantly higher than in the men with UDCT but without thyroid problems.

  7. Repair of Torn Avascular Meniscal Cartilage Using Undifferentiated Autologous Mesenchymal Stem Cells: From In Vitro Optimization to a First‐in‐Human Study

    Science.gov (United States)

    Whitehouse, Michael R.; Howells, Nicholas R.; Parry, Michael C.; Austin, Eric; Kafienah, Wael; Brady, Kyla; Goodship, Allen E.; Eldridge, Jonathan D.; Blom, Ashley W.

    2016-01-01

    Abstract Meniscal cartilage tears are common and predispose to osteoarthritis (OA). Most occur in the avascular portion of the meniscus where current repair techniques usually fail. We described previously the use of undifferentiated autologous mesenchymal stem cells (MSCs) seeded onto a collagen scaffold (MSC/collagen‐scaffold) to integrate meniscal tissues in vitro. Our objective was to translate this method into a cell therapy for patients with torn meniscus, with the long‐term goal of delaying or preventing the onset of OA. After in vitro optimization, we tested an ovine‐MSC/collagen‐scaffold in a sheep meniscal cartilage tear model with promising results after 13 weeks, although repair was not sustained over 6 months. We then conducted a single center, prospective, open‐label first‐in‐human safety study of patients with an avascular meniscal tear. Autologous MSCs were isolated from an iliac crest bone marrow biopsy, expanded and seeded into the collagen scaffold. The resulting human‐MSC/collagen‐scaffold implant was placed into the meniscal tear prior to repair with vertical mattress sutures and the patients were followed for 2 years. Five patients were treated and there was significant clinical improvement on repeated measures analysis. Three were asymptomatic at 24 months with no magnetic resonance imaging evidence of recurrent tear and clinical improvement in knee function scores. Two required subsequent meniscectomy due to retear or nonhealing of the meniscal tear at approximately 15 months after implantation. No other adverse events occurred. We conclude that undifferentiated MSCs could provide a safe way to augment avascular meniscal repair in some patients. Registration: EU Clinical Trials Register, 2010‐024162‐22. Stem Cells Translational Medicine 2017;6:1237–1248 PMID:28186682

  8. Implantation of undifferentiated and pre-differentiated human neural stem cells in the R6/2 transgenic mouse model of Huntington’s disease

    Directory of Open Access Journals (Sweden)

    El-Akabawy Gehan

    2012-08-01

    Full Text Available Abstract Background Cell therapy is a potential therapeutic approach for several neurodegenetative disease, including Huntington Disease (HD. To evaluate the putative efficacy of cell therapy in HD, most studies have used excitotoxic animal models with only a few studies having been conducted in genetic animal models. Genetically modified animals should provide a more accurate representation of human HD, as they emulate the genetic basis of its etiology. Results In this study, we aimed to assess the therapeutic potential of a human striatal neural stem cell line (STROC05 implanted in the R6/2 transgenic mouse model of HD. As DARPP-32 GABAergic output neurons are predominately lost in HD, STROC05 cells were also pre-differentiated using purmorphamine, a hedgehog agonist, to yield a greater number of DARPP-32 cells. A bilateral injection of 4.5x105 cells of either undifferentiated or pre-differentiated DARPP-32 cells, however, did not affect outcome compared to a vehicle control injection. Both survival and neuronal differentiation remained poor with a mean of only 161 and 81 cells surviving in the undifferentiated and differentiated conditions respectively. Only a few cells expressed the neuronal marker Fox3. Conclusions Although the rapid brain atrophy and short life-span of the R6/2 model constitute adverse conditions to detect potentially delayed treatment effects, significant technical hurdles, such as poor cell survival and differentiation, were also sub-optimal. Further consideration of these aspects is therefore needed in more enduring transgenic HD models to provide a definite assessment of this cell line’s therapeutic relevance. However, a combination of treatments is likely needed to affect outcome in transgenic models of HD.

  9. Heterogeneity of the cytokinome in undifferentiated arthritis progressing to rheumatoid arthritis and its change in the course of therapy. Move toward personalized medicine.

    Science.gov (United States)

    Brzustewicz, Edyta; Bzoma, Izabella; Daca, Agnieszka; Szarecka, Maria; Bykowska, Malgorzata Sochocka; Witkowski, Jacek M; Bryl, Ewa

    2017-09-01

    To conduct a comprehensive analysis of cytokine concentrations in sera and mononuclear cell supernatants in order to examine inter- and intra-individual cytokine variations in undifferentiated arthritis progressing to rheumatoid arthritis and healthy control groups. Patients with UA (undifferentiated arthritis) developing RA (rheumatoid arthritis) (UA→RA) (n=16) and healthy controls (n=16) were enrolled into the study. UA→RA patients were followed up for six months since the final RA diagnosis. Cytokines IFN-γ, IL-10, TNF, IL-17A, IL-6, IL-1β, IL-2 in sera and mononuclear cell supernatants in 72h and 120h culture variants with- and without anti-CD3 stimulations were assayed using flow cytometric bead array. The cytokine profile of UA→RA differs from the healthy individual cytokine profile. It is possible to observe specific cytokine pattern characterizing each patient, which alters during course of disease. Specifically, we can distinguish three UA→RA cohorts: the group of patients susceptible to the therapy, characterized by the drop of cytokine levels between 1st and 3rd visit with visible decrease of cytokines in 2nd visit and then secondary slighter increase in 3rd visit; the group of patients refractory or clinically worsening on the therapy, characterized by the highest cytokine levels at 2nd visit with secondary decrease in 3rd visit; and the group of patients with variable responses to the therapy without any specific common cytokine pattern. The cytokine patterns in supernatants of PBMC stimulated anti-CD3 for 72h and 120h are very similar. The personal profile including multiplexed cytokine patterns in serum and supernatant may be potentially used for optimization of therapy introduction and monitoring. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Contribution To The Geology Of Basement Rocks In The South Western Desert Of Egypt

    International Nuclear Information System (INIS)

    Sadek, M.F.; Khyamy, A.A.

    2003-01-01

    Three major Precambrian basement inliers are exposed in the South Western Desert of Egypt between Long. 29 degree E and the River Nile within the Uweinat-Bir Safsaf-Aswan E-W uplift system. These are Bir Safsaf, Gabal EI-Asr and Gabal Umm Shaghir areas. Smaller outcrops include Gabal EI-Gara El-Hamra and Gabal El-Gara EI-Soda, Gabal Siri, GabaI EI-Fantas and Aswan-Kalabsha area as well as the scattered outcrops around Darb El-Arbain road. Band ratios 5/7, 5/1, 4 of Landsat TM images were applied to delineate the borders, the lithologic units and structural features of low relief basement outcrops within the surrounding flat lying sedimentary rocks and sand plains. These basement rocks comprise ortho gneisses (assumed by many authors as related to old continent pre Pan-African rocks), G 1 tonalite-granodiorite, and G2 monzogranite-alkali feldspar granite intruded by variable dykes. The boundaries between the basement exposures and the sedimentary rocks are marked by nonconformity surfaces or sets of faults. Both basement and sedimentary rocks are intruded by Mesozoic syenite-G3 granites, rhyolite, trachytic plugs and Upper Cretaceous to Tertiary basalts. The basement exposures are structurally controlled by major E- W fault systems. Their vertical uplifting is overprinted by folding the overlying sedimentary rocks. This study revealed that, the different basement exposures in the SE of the Western Desert of Egypt are similar in appearance and field relations to the Pan-African basement rocks extending towards the east of the River Nile and exposed everywhere in the Eastern Desert of Egypt

  11. Mineralogical characteristics of Cretaceous-Tertiary kaolins of the Douala Sub-Basin, Cameroon

    Science.gov (United States)

    Bukalo, Nenita N.; Ekosse, Georges-Ivo E.; Odiyo, John O.; Ogola, Jason S.

    2018-05-01

    As a step in evaluating the quality of Cretaceous-Tertiary kaolins of the Douala Sub-Basin, their mineralogical characteristics were determined. The X-ray diffractometry technique was used to identify and quantify the mineral phases present in bulk and analysis, thermal gravimetric analysis, and heat flow) were conducted to further characterise the kaolins. The main mineral phases present in the studied Cretaceous-Tertiary kaolins of the Douala Sub-Basin were kaolinite > smectite > illite, with mean values of 33.01 > 11.20 > 4.41 wt %; and 72.23 > 10.69 > 4.69 wt %, in bulk and <2 μm fractions, respectively. The kaolins, micromorphologically, consisted of pseudo-hexagonal and thin platy particles; swirl-textured particles; and books or stacks of kaolinite particles. Three main reactions occurred during heating of the kaolins: a low temperature endothermic reaction, observed between 48 and 109 °C; a second low temperature peak, observed between 223 and 285 °C; and a third endothermic peak was found between 469 and 531 °C. In addition, an exothermic reaction also occurred between 943 and 988 °C in some of the samples. The absence of primary minerals such as feldspars and micas in most of these kaolins is an indication of intensive weathering, probably due to the humid tropical climate of the region. The different morphologies suggested that these kaolins might have been transported. Therefore, a humid tropical climate was responsible for the formation of Cretaceous-Tertiary kaolins of the Douala Sub-Basin through intense weathering of surrounding volcanic and metamorphic rocks.

  12. Rock Slope Design Criteria : Executive Summary Report

    Science.gov (United States)

    2010-06-01

    Based on the stratigraphy and the type of slope stability problems, the flat lying, Paleozoic age, sedimentary rocks of Ohio were divided into three design units: 1) competent rock design unit consisting of sandstones, limestones, and siltstones that...

  13. Rock glaciers, Central Andes, Argentina, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — Primary rock glaciers are fed by avalanche chutes. At the El Salto rock glacier, surveys have been undertaken in order to determine the creep rate. Between 1981 and...

  14. Epigenetic alterations of sedimentary rocks at deposits

    International Nuclear Information System (INIS)

    Komarova, G.V.; Kondrat'eva, I.A.; Zelenova, O.I.

    1980-01-01

    Notions are explained, and technique for studying epigenetic alterations of sedimentary rocks at uranium deposits is described. Main types of epigenetic transformations and their mineralogic-geochemical characteristics are considered. Rock alterations, accompanying uranium mineralization, can be related to 2 types: oxidation and reduction. The main mineralogic-geochemical property of oxidation transformations is epigenetic limonitization. Stratal limonitization in primary grey-coloured terrigenic rocks and in epigenetically reduced (pyritized) rocks, as well as in rock, subjected to epigenetic gleying, are characterized. Reduction type of epigenetic transformations is subdivided into sulphidic and non-sulphidic (gley) subtypes. Sulphidic transformations in grey-coloured terrigenic rocks with organic substance of carbonic row, in rocks, containing organic substance of oil row, sulphide transformations of sedimentary rocks, as well as gley transformations, are considered

  15. Range sections as rock models for intensity rock scene segmentation

    CSIR Research Space (South Africa)

    Mkwelo, S

    2007-11-01

    Full Text Available can be drawn. • A methodology for rock-scene segmentation that com- bines intensity and range image analysis to reduce the effects of texture and color density variations is presented. • Post-processing in the form of outlier rejection... to the environment under imaging: poor lighting; color density and texture variations. Lighting conditions have been controlled through the elimination of natural lighting and proper design of syn- thetic lighting [3]. We present a methodology that avoids...

  16. Structural Diversity in Tertiary Education. Go8 Backgrounder 18

    Science.gov (United States)

    Group of Eight (NJ1), 2010

    2010-01-01

    Projections of future population and tertiary education participation indicate that Australia needs soon to start planning for another surge in school leavers entering tertiary education from 2015, together with increased demand for greater skills deepening by adult workers. Hence it is necessary to find cost-effective supply solutions that…

  17. Crime and Crime Management in Nigeria Tertiary Institutions

    Science.gov (United States)

    Adebanjo, Margaret Adewunmi

    2014-01-01

    This paper examines crime and its management in Nigerian tertiary institutions. Tertiary institutions today have become arenas for crime activities such as rape, cultism, murder, theft, internet fraud, drug abuse, and examination malpractices. This paper delves into what crime is, and its causes; and the positions of the law on crime management.…

  18. Determinants of propensity of tertiary agricultural students in Ghana ...

    African Journals Online (AJOL)

    The study aimed to identify factors that affect the decision of tertiary agricultural students in Ghana to enter agribusiness as a self-employment venture after graduation. The results showed that tertiary agricultural students in Ghana were predominantly males with little or no farming background. They had a rather moderate ...

  19. Capacity of non-tertiary Kenyan health facilities selected for ...

    African Journals Online (AJOL)

    Capacity of non-tertiary Kenyan health facilities selected for decentralised dental training. ... Design: A descriptive cross-sectional study. Setting: The Dental departments of six non-tertiary Kenyan health facilities. Main outcome measures: Capacity of the hospitals to be used as sites for decentralised dental education.

  20. Education and training in recreation management at tertiary ...

    African Journals Online (AJOL)

    Tertiary institutions should realise the gaps and opportunities that could be filled in recreation management training. The current article reviews literature focussing on the ... This information is used to stress the need to train professionals in recreation management at tertiary institutions. Recommendations are made as to the ...

  1. Massification and Quality Assurance in Tertiary Education: The ...

    African Journals Online (AJOL)

    The study sets out to examine massification and its impact on quality assurance in tertiary education and the extent to which lecturer–student ratio, adequacy of infrastructure and pedagogical resources affect quality in tertiary institutions. Two research questions and one hypothesis were posed to guide the investigation.

  2. This paper investigates the attitudes of some university and tertiary ...

    African Journals Online (AJOL)

    tertiary institution students to codeswitching. Respondents were drawn from four tertiary institutions located in the Southwestern part of Nigeria. A structured questionnaire ... attitude to code switching, and therefore the high representation of Yoruba ... utterance, conversation or writing has been extensively researched by.

  3. Ensuring Effective Mentoring in Tertiary Institutions in Anambra State ...

    African Journals Online (AJOL)

    This paper concerns itself only with ascertaining the strategies that could ensure effective mentoring in tertiary institutions. The survey method was employed. The study population comprised 78 teacher educators in tertiary institutions in Anambra State. One research question guided the study while one null hypothesis was ...

  4. Academic mentoring and the future of tertiary education in Nigeria ...

    African Journals Online (AJOL)

    Tertiary education is a major outlet for the provision of high manpower for national development. This paper therefore highlighted the challenges of tertiary education in Nigeria, early perspectives of mentoring undergraduates, the rationale for academic mentoring, the role of a mentor, and the role of library as catalyst in the ...

  5. Opinions of Nigerian students in tertiary institutions on family size ...

    African Journals Online (AJOL)

    The study examined the opinions of Nigerian students in tertiary institutions on their ideal family size. It was conducted among students in four tertiary institutions in Edo State of Nigeria. A sample size of 454 final year students was randomly drawn from the halls of residence in the institutions using the stratified sampling ...

  6. The Impediments Facing Community Engagement in Omani Educational Tertiary Institutions

    Science.gov (United States)

    Issa, Jinan Hatem

    2016-01-01

    Prior to the vital role that social capital plays in accomplishing prosperity for any educational tertiary institution, it was emphasised in several countries' agendas, including the Sultanate of Oman. This study endeavours to explore the impediments facing the enhancement of the social capital in Omani educational tertiary institutions through…

  7. Literacy Skills Development for Tertiary Institutions: A Case Study of ...

    African Journals Online (AJOL)

    Literacy Skills Development for Tertiary Institutions: A Case Study of the University of Calabar. ... These were drawn from five faculties, namely Education, Social Sciences, Law, Arts and Agriculture. The study observed that there is a ... more literacy skills. Key Words: Literacy skills, university, Nigeria, tertiary institution ...

  8. Maternal mortality ratio in a Tertiary Hospital offering free maternity ...

    African Journals Online (AJOL)

    AbstRACt. Aim: To determine annual trends of maternal mortality ratio in a tertiary hospital offering free maternity services. settings and Design: This retrospective descriptive study was conducted at the Mother and Child Hospital Akure, Ondo. State, a busy purpose‑built tertiary care facility premised on evidence‑based ...

  9. The Returns of Investment in Tertiary Technological Education in Greece.

    Science.gov (United States)

    Tsamadias, Constantinos

    2002-01-01

    Return on investment was estimated from earnings data on Greek graduates of tertiary technological education and secondary education, using elaborate and Mincerian estimation models. Return rates were similar in both methods. Differences were greater for females. Both societal and individual investment in tertiary technological education was…

  10. Terminology development at tertiary institutions: A South African ...

    African Journals Online (AJOL)

    Terminology development at tertiary institutions: A South African perspective. M Alberts. Abstract. There is a dire need in South Africa for multilingual polythematic terminology. Currently no tertiary institution presents terminology theory and practice as a fully-fledged subject and there is also no sufficient mechanism for the ...

  11. Characterization of the translocation breakpoint sequences of two DEK-CAN fusion genes present in t(6;9) acute myeloid leukemia and a SET-CAN fusion gene found in a case of acute undifferentiated leukemia

    NARCIS (Netherlands)

    von Lindern, M.; Breems, D.; van Baal, S.; Adriaansen, H.; Grosveld, G.

    1992-01-01

    The t(6;9) associated with a subtype of acute myeloid leukemia (AML) was shown to generate a fusion between the 3' part of the CAN gene on chromosome 9 and the 5' part of the DEK gene on chromosome 6. The same part of the CAN gene appeared to be involved in a case of acute undifferentiated leukemia

  12. Diffusion-Weighted Imaging Using a Readout-Segmented, Multishot EPI Sequence at 3 T Distinguishes between Morphologically Differentiated and Undifferentiated Subtypes of Thyroid Carcinoma—A Preliminary Study

    Directory of Open Access Journals (Sweden)

    Stefan Schob

    2016-10-01

    Full Text Available BACKGROUND: Thyroid carcinomas represent the most frequent endocrine malignancies. Recent studies were able to distinguish malignant from benign nodules of the thyroid gland with diffusion-weighted imaging (DWI. Although this differentiation is undoubtedly helpful, presurgical discrimination between well-differentiated and undifferentiated carcinomas would be crucial to define the optimal treatment algorithm. Therefore, the aim of this study was to investigate if readout-segmented multishot echo planar DWI is able to differentiate between differentiated and undifferentiated subtypes of thyroid carcinomas. PATIENTS AND METHODS: Fourteen patients with different types of thyroid carcinomas who received preoperative DWI were included in our study. In all lesions, apparent diffusion coefficient (ADCmin, ADCmean, ADCmax, and D were estimated on the basis of region of interest measurements after coregistration with T1-weighted, postcontrast images. All tumors were resected and analyzed histopathologically. Ki-67 index, p53 synthesis, cellularity, and total and average nucleic areas were estimated using ImageJ version 1.48. RESULTS: Analysis of variance revealed a statistically significant difference in ADCmean values between differentiated and undifferentiated thyroid carcinomas (P = .022. Spearman Rho calculation identified significant correlations between ADCmax and cell count (r = 0.541, P = .046 as well as between ADCmax and total nuclei area (r = 0.605, P = .022. CONCLUSION: DWI can distinguish between differentiated and undifferentiated thyroid carcinomas.

  13. Rock-degrading endophytic bacteria in cacti

    Science.gov (United States)

    M. Esther Puente; Ching Y. Li; Yoav Bashan

    2009-01-01

    A plant-bacterium association of the cardon cactus (Pachycereus pringlei) and endophytic bacteria promotes establishment of seedlings and growth on igneous rocks without soil. These bacteria weather several rock types and minerals, unbind significant amounts of useful minerals for plants from the rocks, fix in vitro N2. produce...

  14. The History of Rock Art Research

    Indian Academy of Sciences (India)

    The History of Rock Art Research. Rock art in South India was discovered as early as 1891.The earliest discovery of petroglyphs on the Koppagallu hill in Bellary district was made by Fred Fawcett (1892) who with the ... Fawcett, as Archibald Carlylle in Central India, recognized the prehistoric antiquity of the Rock art.

  15. Discharge-mechanical method of rock breakage

    Science.gov (United States)

    Vazhov, V. F.; Datskevich, S. Y.; Zhurkov, M. Y.; Muratov, V. M.; Jeffryes, B.

    2017-05-01

    The electric discharge and mechanical technology of hard rock breakage was developed on the ground of mechanical and electrical pulse methods and it was tested for purposes of deep drilling. It was demonstrated that, due to breakage of the rock surface by electric discharges, the rock excavation volume (breakage performance) is significantly improved as compared to conventional mechanical methods.

  16. K-Ar ages of basic rocks in the Patia Valley, southwest Colombia

    Science.gov (United States)

    De Souza, Hughes A. F.; Espinosa, Armando; Delaloye, Michel

    1984-08-01

    The Patia Valley situated between the Western and Central Cordilleras of the southwest Colombian Andes contains two areas in which Mesozoic basic and ultrabasic rocks crop out in abundance. Late Cretaceous Diabase Group pillow basalts which make up much of the Western Cordillera are at least 81 ± 5 Ma in the E1 Tambo-E1 Peñol area. 105-97 Ma hornblende and whole-rock dates from the ophiolitic Los Azules complex indicate an Albian age of formation, although many dates are lower (65-62 Ma) owing the low-grade ocean-floor metamorphism. The metamorphic age distribution here supports an end of Cretaceous emplacement for the complex rather than the Early-Mid Cretaceous emplacement suggested for North Colombian ophiolites similarly aligned along the Romeral fault system. Tertiary dacites intruding the Low Azules complex are 36-15 Ma.

  17. ESR dating of fault rocks

    International Nuclear Information System (INIS)

    Lee, Hee Kwon

    2002-03-01

    Past movement on faults can be dated by measurement of the intensity of ESR signals in quartz. These signals are reset by local lattice deformation and local frictional heating on grain contacts at the time of fault movement. The ESR signals then trow back as a result of bombardment by ionizing radiation from surrounding rocks. The age is obtained from the ratio of the equivalent dose, needed to produce the observed signal, to the dose rate. Fine grains are more completely reset during faulting, and a plot of age vs grain size shows a plateau for grains below critical size : these grains are presumed to have been completely zeroed by the last fault activity. We carried out ESR dating of fault rocks collected from the Yangsan fault system. ESR dates from the this fault system range from 870 to 240 ka. Results of this research suggest that long-term cyclic fault activity continued into the pleistocene

  18. Applying rock mass classifications to carbonate rocks for engineering purposes with a new approach using the rock engineering system

    Directory of Open Access Journals (Sweden)

    Gioacchino Francesco Andriani

    2017-04-01

    Full Text Available Classical rock mass classification systems are not applicable to carbonate rocks, especially when these are affected by karst processes. Their applications to such settings could therefore result in outcomes not representative of the real stress–strain behavior. In this study, we propose a new classification of carbonate rock masses for engineering purposes, by adapting the rock engineering system (RES method by Hudson for fractured and karstified rock masses, in order to highlight the problems of implementation of geomechanical models to carbonate rocks. This new approach allows a less rigid classification for carbonate rock masses, taking into account the local properties of the outcrops, the site conditions and the type of engineering work as well.

  19. Uranium deposits in volcanic rocks

    International Nuclear Information System (INIS)

    1985-01-01

    Twenty-eight papers were presented at the meeting and two additional papers were provided. Three panels were organized to consider the specific aspects of the genesis of uranium deposits in volcanic rocks, recognition criteria for the characterization of such deposits, and approaches to exploration. The papers presented and the findings of the panels are included in the Proceedings. Separate abstracts were prepared for each of these papers

  20. ESR dating of fault rocks

    International Nuclear Information System (INIS)

    Lee, Hee Kwon

    2003-02-01

    Past movement on faults can be dated by measurement of the intensity of ESR signals in quartz. These signals are reset by local lattice deformation and local frictional heating on grain contacts at the time of fault movement. The ESR signals then grow back as a result of bombardment by ionizing radiation from surrounding rocks. The age is obtained from the ratio of the equivalent dose, needed to produce the observed signal, to the dose rate. Fine grains are more completely reset during faulting, and a plot of age vs. grain size shows a plateau for grains below critical size; these grains are presumed to have been completely zeroed by the last fault activity. We carried out ESR dating of fault rocks collected near the Gori nuclear reactor. Most of the ESR signals of fault rocks collected from the basement are saturated. This indicates that the last movement of the faults had occurred before the Quaternary period. However, ESR dates from the Oyong fault zone range from 370 to 310 ka. Results of this research suggest that long-term cyclic fault activity of the Oyong fault zone continued into the Pleistocene

  1. Source rock hydrocarbons. Present status

    International Nuclear Information System (INIS)

    Vially, R.; Maisonnier, G.; Rouaud, T.

    2013-01-01

    This report first presents the characteristics of conventional oil and gas system, and the classification of liquid and gaseous non conventional hydrocarbons, with the peculiar case of coal-bed methane. The authors then describe how source rock hydrocarbons are produced: production of shale oils and gases (horizontal drilling, hydraulic fracturing, exploitation) and of coal-bed methane and coal mine methane. In the next part, they address and discuss the environmental impact of source rock hydrocarbon production: installation footprint, water resource management, drilling fluids, fracturing fluids composition, toxicity and recycling, air pollution, induced seismicity, pollutions from other exploitation and production activities. They propose an overview of the exploitation and production of source rock gas, coal-bed gas and other non conventional gases in the world. They describe the current development and discuss their economic impacts: world oil context and trends in the USA, in Canada and other countries, impacts on the North American market, on the world oil industry, on refining industries, on the world oil balance. They analyse the economic impacts of non conventional gases: development potential, stakes for the world gas trade, consequence for gas prices, development opportunities for oil companies and for the transport sector, impact on CO 2 emissions, macro-economic impact in the case of the USA

  2. The impact of mechanical properties of rock to the collision of rock piece

    Directory of Open Access Journals (Sweden)

    Borut Macuh

    2007-06-01

    Full Text Available The paper presents the analytical solution of the rock piece motion considering influences of geometrical and mechanical characteristics of rock mass on the arbitrary slope. The main objective of the paper is to determine the motion of the rock piece considering possibility of rock piece failure due to collision. Brief description of the analytical solution of the rock piece motion on a steep slope is given. The laboratory tests were performed to determine uniaxial compressive strength and elastic properties of the considered rock mass. Further, velocities that cause rock piece failure were determined. These maximum velocities indirectly belong to certain mass of rock piece and can be lower than velocities calculated in rock-fall analysis for certain slope geometry. Consequently, the energy magnitude is limited, because at certain velocity and mass of rock piece bigger pieces crash at collision.

  3. A Review on the British Rock Music

    OpenAIRE

    Hutapea, Alfian Hadi Pranata

    2011-01-01

    Music has an important role in people’s life. In people’s daily, music is often hearing of course and in people’s customs and traditions music is also be used. Music has many genres, one of them is rock music. Many people like rock music especially youngman because rock music has given a message in a song through enthusiasm expression. Rock music has many subgenres and each of subgenres have a distinctive feature. The developing of rock music is very wide in the world, especially in Great Bri...

  4. The physical principles of rock magnetism

    CERN Document Server

    Stacey, Frank

    1974-01-01

    Developments in Solid Earth Geophysics 5: The Physical Principles of Rock Magnetism explores the physical principles of rock magnetism, with emphasis on the properties of finely divided magnetic materials. It discusses the origin and stability of rock magnetizations, the role of remanent magnetism in interpreting magnetic surveys, magnetic anisotropy as an indicator of rock fabric, and the relationship between piezomagnetic changes and seismic activity. Organized into 13 chapters, this volume discusses the properties of solids, magnetite and hematite grains, and rocks with magnetite grains

  5. Carbonate rock depositional models: A microfacies approach

    Energy Technology Data Exchange (ETDEWEB)

    Carozzi, A.V.

    1988-01-01

    Carbonate rocks contain more than 50% by weight carbonate minerals such as calcite, dolomite, and siderite. Understanding how these rocks form can lead to more efficient methods of petroleum exploration. Micofacies analysis techniques can be used as a method of predicting models of sedimentation for carbonate rocks. Micofacies in carbonate rocks can be seen clearly only in thin sections under a microscope. This section analysis of carbonate rocks is a tool that can be used to understand depositional environments, diagenetic evolution of carbonate rocks, and the formation of porosity and permeability in carbonate rocks. The use of micofacies analysis techniques is applied to understanding the origin and formation of carbonate ramps, carbonate platforms, and carbonate slopes and basins. This book will be of interest to students and professionals concerned with the disciplines of sedimentary petrology, sedimentology, petroleum geology, and palentology.

  6. Tertiary ice sheet dynamics: The Snow Gun Hypothesis

    Science.gov (United States)

    Prentice, M. L.; Matthews, R. K.

    1991-04-01

    We observe strong negative correlation between Tertiary low- to mid-latitude planktonic foraminiferal δ18O and the difference between these data and coeval benthic foraminiferal δ18O. Late Quaternary data do not show this correlation. Coupling statistical model/δ18O comparisons and evidence for Antarctic ice and ocean temperature variation, we infer that Tertiary ice volume, recorded by tropical planktonic δ18O, increased as the deep ocean warmed. Because the isotopic signatures of deepwater temperature variation and ice volume change were of opposite sign, the sum of these signals in Tertiary benthic δ18O became lost in the noise. This renders low correlation between Tertiary planktonic and benthic δ18O time series compared to late Quaternary data. We contend that Tertiary ice sheet growth was commonly driven by warming of deep water from low- to mid-latitude marginal seas (snow gun hypothesis). In contrast, late Quaternary ice sheets grew as deep water, formed at high latitude, cooled. Because tectonic forcing and orbital forcing at low-latitude primarily controlled production and temperature variations of this Warm Saline Deep Water, these influences largely dictated Tertiary ice volume fluctuations. Through the Tertiary, we infer ice volume fluctuations to be an important component of sea level history on timescales between 103 and 107 years.

  7. Sorption of radionuclides by tertiary clays

    International Nuclear Information System (INIS)

    Wagner, J.F.; Czurda, K.A.

    1990-01-01

    The sorption capacity of different clay types for some metals (Co, Cs, Sr and Zn), occurring as common radionuclides in radioactive waste deposits, had been analysed by a static (batch technique) and a dynamic method (percolation tests, in which the driving force is a hydraulic gradient). Sorption capacity generally increased with an increasing pH of solution. A decrease of sorption capacity had been observed in the order Zn > Cs ≥ Co > Sr for the batch and Cs > Zn > Sr > Co for the percolation tests. Clay marls showed a distinctly higher sorption respectively retention capacity as pure clays. Sorption capacity depends on solution parameters like type and concentration of radionuclide, pH, salt concentration, etc., and on rock parameters like mineral content (e.g. swelling clay minerals and carbonates), organic material, rock pH, micro fabric, etc. A third parameter of great influence is the contact time between clay and solution. The adsorption isotherms reflect two different adsorption mechanisms: a very rapid adsorption (a few minutes) on the external surfaces of clay minerals and a slow adsorption process (weeks and longer), due to the diffusion of metal ions into the interlayer space of clay minerals. 12 refs., 9 figs., 1 tab

  8. Dating and source determination of volcanic rocks from Khunik area (South of Birjand, South Khorasan using Rb-Sr and Sm-Nd isotopes

    Directory of Open Access Journals (Sweden)

    Somayeh Samiee

    2016-12-01

    Full Text Available The Khunik area is located in the south of Birjand, Khorasan province, in the eastern margin of Lut block. Tertiary volcanic rocks have andesite to trachy-andesite composition. Dating analyzing by Rb-Sr method on plagioclase and hornblende as well as whole-rock isochron method was performed on pyroxene-hornblende andesite rock unit. On this basis the emplacement age is Upper Paleocene (58±11 Ma. These rocks have initial 87Sr/86Sr and εNd 0.7046-0.7049 and 2.16-3.12, respectively. According to isotopic data, volcanic rocks originated from depleted mantle and have the least crust contamination while it was fractionated. Geochemically, Khunik volcanic rocks have features typical of calk-alkaline to shoshonite and are metaluminous. Enrichment in LILEs and typical negative anomalies of Nb and Ti are evidences that the volcanic rocks formed in a subduction zone and active continental margin. Modeling suggests that these rocks were derived dominantly from 1–5% partial melting of a mainly spinel garnet lherzolite mantle source that is metasomatized by slab-derived fluid.

  9. A fractional derivative approach to full creep regions in salt rock

    Science.gov (United States)

    Zhou, H. W.; Wang, C. P.; Mishnaevsky, L.; Duan, Z. Q.; Ding, J. Y.

    2013-08-01

    Based on the definition of the constant-viscosity Abel dashpot, a new creep element, referred to as the variable-viscosity Abel dashpot, is proposed to characterize damage growth in salt rock samples during creep tests. Ultrasonic testing is employed to determine a formula of the variable viscosity coefficient, indicating that the change of the variable viscosity coefficient with the time meets a negative exponent law. In addition, by replacing the Newtonian dashpot in the classical Nishihara model with the variable-viscosity Abel dashpot, a damage-mechanism-based creep constitutive model is proposed on the basis of time-based fractional derivative. The analytic solution for the fractional-derivative creep constitutive model is presented. The parameters of the fractional derivative creep model are determined by the Levenberg-Marquardt method on the basis of the experimental results of creep tests on salt rock. Furthermore, a sensitivity study is carried out, showing the effects of stress level, fractional derivative order and viscosity coefficient exponent on creep strain of salt rock. It is indicated that the fractional derivative creep model proposed in the paper provides a precise description of full creep regions in salt rock, i.e., the transient creep region (the primary region), the steady-state creep region (the secondary region) and the accelerated creep region (the tertiary region).

  10. Tertiary evolution of the northeastern Venezuela offshore

    Science.gov (United States)

    Ysaccis B., Raul

    1998-12-01

    On the northeastern offshore Venezuela, the pre-Tertiary basement consists of a deeply subducted accretionary complex of a Cretaceous island arc system that formed far to the west of its present location. The internal structure of this basement consists of metamorphic nappes that involve passive margin sequences, as well as oceanic (ophiolitic) elements. The Tertiary evolution of the northeastern Venezuela offshore is dominated by Paleogene (Middle Eocene-Oligocene) extension and Neogene transtension, interrupted by Oligocene to Middle Miocene inversions. The Paleogene extension is mainly an arc-normal extension associated with a retreating subduction boundary. It is limited to the La Tortuga and the La Blanquilla Basins and the southeastern Margarita and Caracolito subbasins. All of these basins are farther north of and not directly tied to the El Pilar fault system. On a reconstruction, these Paleogene extensional systems were located to the north of the present day Maracaibo Basin. By early Miocene the leading edge of the now overall transpressional system had migrated to a position to the north of the Ensenada de Barcelona. This relative to South America eastward migration is responsible for the Margarita strike-slip fault and the major inversions that began during the Oligocene and lasted into the Middle Miocene. The Bocono-El Pilar-Casanay-Warm Springs and the La Tortuga-Coche-North Coast fault systems are exclusively Neogene with major transtension occurring during the Late Miocene to Recent and act independently from the earlier Paleogene extensional system. They are responsible for the large Neogene transtensional basins of the area: the Cariaco trough, the Northern Tuy-Cariaco and the Paria sub-basins, and the Gulf of Paria Basin. This latest phase is characterized by strain-partitioning into strike slip faults, a transtensional northern domain and a transpressional southern domain that is responsible for the decollement tectonics and/or inversions of the

  11. Rock glaciers, Disko Island, Greenland, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — Disko Island (8600 km2) is situated west of central mainland Greenland. The island is part of the Tertiary volcanic province of West Greenland and is mainly made up...

  12. Production of deoxyschizandrin and γ-schizandrin in shoot-differentiating and undifferentiating callus cultures of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine).

    Science.gov (United States)

    Szopa, Agnieszka; Ekiert, Halina

    2013-06-10

    Shoot-differentiating and undifferentiating callus cultures of Schisandra chinensis were cultured, respectively, on six and two variants of the Murashige and Skoog (MS) medium, differing in the concentration of cytokinin, 6-benzyladenine (BA) and auxin, α-naphthaleneacetic acid (NAA). In methanolic extracts from the biomass of both types of culture the amounts of two lignans: deoxyschizandrin and γ-schizandrin were estimated using the HPLC method. The levels of both compounds in the shoot-differentiating callus extracts were dependent on the concentration of BA and NAA in the MS medium variants. The amounts of deoxyschizandrin were high and varied over a wide range from 34.23 to 308.51 mg 100 g(-1) dry weight (DW); the amounts of γ-schizandrin were of a different order and ranged from 1.07 to 22.09 mg 100 g(-1) DW. In the extracts from undifferentiating callus the amounts of both compounds were lower and almost identical on the tested variants of the MS medium, equal, respectively, to about 18.5 mg 100 g(-1) DW deoxyschizandrin, and about 1.0 mg 100 g(-1) DW γ-schizandrin. The maximum amounts of deoxyschizandrin were obtained on the MS medium variant containing 3 mg l(-1) BA and 1 mg l(-1) NAA. These amounts were 7.5 and 5.1 times higher, respectively, than in the extracts from the leaves (41.01 mg 100 g(-1) DW) and fruits (60.72 mg 100 g(-1) DW) of native plant, analyzed for comparison. The maximum amount of γ-schizandrin in shoot-differentiating callus (22.09 mg 100 g(-1) DW) was comparable with its amount in the leaves (22.27 mg 100 g(-1) DW), but 3 times lower than in the fruits (66.50 mg 100 g(-1) DW). The obtained high amounts of deoxyschizandrin in the extracts of shoot-differentiating callus are of interest from the practical perspective. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. Comparative study of two boron compounds (BPA and BOPP) for the application of BNCT to an animal model of undifferentiated thyroid cancer

    International Nuclear Information System (INIS)

    Dagrosa, Maria A.; Viaggi, Mabel; Juvenal, Guillermo; Pisarev, Mario A.

    2003-01-01

    Boron neutron capture therapy (BNCT) is based on the selective uptake of certain boron compounds by tumors. Once the uptake, relative to normal tissues, is equal of greater than 3, the tumoral area is irradiated with an appropriate neutron beam. The 10 B is then converted into 11 B and this decays releasing an atom of Li, gamma rays and alpha particles. These latter have a high linear energy transfer (LET) and will cause local damage, eventually killing the tumoral cells. At the present time several clinical trials are being conducted in different countries to treat patients with glioblastoma multiform and melanomas. So far the results obtained, specially with this last disease, are quite encouraging. Undifferentiated thyroid cancer (UTC) is a very aggressive tumor which does not respond to the therapies available at the present. Usually it has a very bad prognosis with a very short survival period. We have previously shown that the human UTC cell line ARO has an uptake of borophenylanine (BPA) significantly greater than normal thyroid or than human follicular adenoma cells in culture. Moreover, an animal model for UTC was developed in our laboratory by transplanting the human ARO cells into nude mice. This model closely resembles the evolution of human disease and even produces lung metastasis, like the human. In the present studies we have compared the uptake of two boron compounds: BPA and boronated porphyrin (BOPP). BPA was administered via ip in a dose of 600 mg/kg body weight, while BOPP was given either ip or iv, in doses of 10 and 100 mg/kg body weight. The animals were sacrificed at different times after the injection: up to 150 min for BPA and after 24 h with BOPP. The concentration of boron was determined by ICP-AES. The results obtained showed that the uptake of BPA was significantly greater in the tumoral area and in the infiltrated surrounding skin than in the other organs examined (liver, kidney, lung, mice thyroid, blood, spleen and distal skin

  14. Hot Dry Rock; Geothermal Energy

    Energy Technology Data Exchange (ETDEWEB)

    None

    1990-01-01

    The commercial utilization of geothermal energy forms the basis of the largest renewable energy industry in the world. More than 5000 Mw of electrical power are currently in production from approximately 210 plants and 10 000 Mw thermal are used in direct use processes. The majority of these systems are located in the well defined geothermal generally associated with crustal plate boundaries or hot spots. The essential requirements of high subsurface temperature with huge volumes of exploitable fluids, coupled to environmental and market factors, limit the choice of suitable sites significantly. The Hot Dry Rock (HDR) concept at any depth originally offered a dream of unlimited expansion for the geothermal industry by relaxing the location constraints by drilling deep enough to reach adequate temperatures. Now, after 20 years intensive work by international teams and expenditures of more than $250 million, it is vital to review the position of HDR in relation to the established geothermal industry. The HDR resource is merely a body of rock at elevated temperatures with insufficient fluids in place to enable the heat to be extracted without the need for injection wells. All of the major field experiments in HDR have shown that the natural fracture systems form the heat transfer surfaces and that it is these fractures that must be for geothermal systems producing from naturally fractured formations provide a basis for directing the forthcoming but, equally, they require accepting significant location constraints on HDR for the time being. This paper presents a model HDR system designed for commercial operations in the UK and uses production data from hydrothermal systems in Japan and the USA to demonstrate the reservoir performance requirements for viable operations. It is shown that these characteristics are not likely to be achieved in host rocks without stimulation processes. However, the long term goal of artificial geothermal systems developed by systematic

  15. Big Bang Day : Physics Rocks

    CERN Multimedia

    Brian Cox; John Barrowman; Eddie Izzard

    2008-01-01

    Is particle physics the new rock 'n' roll? The fundamental questions about the nature of the universe that particle physics hopes to answer have attracted the attention of some very high profile and unusual fans. Alan Alda, Ben Miller, Eddie Izzard, Dara O'Briain and John Barrowman all have interests in this branch of physics. Brian Cox - CERN physicist, and former member of 90's band D:Ream, tracks down some very well known celebrity enthusiasts and takes a light-hearted look at why this subject can appeal to all of us.

  16. Frequency Dependent Attenuation in Rocks

    Science.gov (United States)

    1990-01-20

    WORK UNIT ELEMENT NO NO NO ACCESSION NO 62714E 7A10 DA DA 1𔃻 T. ,E (Incude Security Clasification ) Frequency Dependent Attenuation in Rocks Ŗ 0E;SO’.A_...P., and L. Peselnick, Investigation of internal friction in fused quartz, steel , plexiglass, and Westerly granite from 0.01 to 1.00 Hertz at 10- to 10...P., and L. Peselnick, Investigation of internal friction in fused quartz, steel , plexiglas, and Westerly granite from 0.01 to 1.00 Hertz at 10-8 to 10

  17. Cretaceous plutonic rocks in the Donner Lake-Cisco Grove area, northern Sierra Nevada, California

    Science.gov (United States)

    Kulow, Matthew J.; Hanson, Richard E.; Girty, Gary H.; Girty, Melissa S.; Harwood, David S.

    1998-01-01

    The northernmost occurrences of extensive, glaciated exposures of the Sierra Nevada batholith occur in the Donner Lake-Cisco Grove area of the northern Sierra Nevada. The plutonic rocks in this area, which are termed here the Castle Valley plutonic assemblage, crop out over an area of 225 km2 and for the most part are shown as a single undifferentiated mass on previously published geological maps. In the present work, the plutonic assemblage is divided into eight separate intrusive units or lithodemes, two of which each consist of two separate plutons. Compositions are dominantly granodiorite and tonalite, but diorite and granite form small plutons in places. Spectacular examples of comb layering and orbicular texture occur in the diorites. U-Pb zircon ages have been obtained for all but one of the main units and range from ~120 to 114 Ma, indicating that the entire assemblage was emplaced in a narrow time frame in the Early Cretaceous. This is consistent with abundant field evidence that many of the individual phases were intruded penecontemporaneously. The timing of emplacement correlates with onset of major Cretaceous plutonism in the main part of the Sierra Nevada batholith farther south. The emplacement ages also are similar to isotopic ages for gold-quartz mineralization in the Sierran foothills west of the study area, suggesting a direct genetic relationship between the voluminous Early Cretaceous plutonism and hydrothermal gold mineralization.

  18. Are Icelandic rock-slope failures paraglacial? Age evaluation of seventeen rock-slope failures in the Skagafjörður area, based on geomorphological stacking, radiocarbon dating and tephrochronology

    Science.gov (United States)

    Mercier, Denis; Coquin, Julien; Feuillet, Thierry; Decaulne, Armelle; Cossart, Etienne; Jónsson, Helgi Pall; Sæmundsson, Þorstein

    2017-11-01

    In Iceland there are numerous rock-slope failures, especially in the Tertiary basaltic formations of the northern, eastern and northwestern regions. The temporal pattern of rock-slope failures is fundamental for understanding post-glacial events. In the Skagafjörður district, central northern Iceland, 17 rock-slope failures were investigated to determine the age of their occurrence. A geomorphic survey was carried out to identify and characterize landform units, both on the rock-slope failures and in their immediate vicinity. In this coastal area, we used geomorphological stacking which included the relationship between rock-slope failures and raised beaches caused by glacial isostatic rebounds, the chronology of which was established in previous studies. We searched for depressions on the rock-slope failures to then excavate a series of pits and map the stratigraphy. The resulting stratigraphic framework was then validated using (i) radiocarbon dating of wood remains, and (ii) tephrochronology, both of which were complemented by age-depth model calibration. The results confirm that all the rock-slope failures potentially occurred before the Boreal (8 ka), while 94% occurred before the Preboreal (10 ka). They all potentially occurred after the glacial retreat following the maximal ice extent and the Preboreal. More precisely, 11 of them potentially occurred between the Preboreal and the first half of the Holocene. This study demonstrates the relationship between the deglaciation and destabilization of slopes during the paraglacial phase (debuttressing, decompression, glacial isostatic rebound, seismic activity, etc.), which are also controlling factors favouring landsliding, but are difficult to identify for each individual rock-slope failure.

  19. Aquatic Life Criteria - Methyl Tertiary-Butyl Ether (MTBE)

    Science.gov (United States)

    Information pertaining to the 1999 Acute and Chronic Ambient Aquatic Life Water Quality Criteria for Methyl Tertiary-Butyl Ether (MTBE) for freshwater and salt water. Information includes the safe levels of MTBE that should protect the majority of species.

  20. Language and Literature in Tertiary Education: The Case for Stylistics.

    Science.gov (United States)

    Buckledee, Steve

    2002-01-01

    Advocates the use of stylistics for teaching English-as-a-Foreign-Language at the tertiary level. Describes stylistics, discusses discourse conventions and grammatical structure, and examines stylistic analysis of a Shakespearian sonnet and a poem. (Author/VWL)

  1. Social Activities and Manifest Anxiety among Freshmen in Tertiary ...

    African Journals Online (AJOL)

    ) in tertiary institutions in Lagos state of Nigeria were analysed to determine the relationship between social activities and manifest anxiety. Social activities in the study were measured in terms of freshmen adjustment to religious activities and ...

  2. Laboratory characterization of rock joints

    Energy Technology Data Exchange (ETDEWEB)

    Hsiung, S.M.; Kana, D.D.; Ahola, M.P.; Chowdhury, A.H.; Ghosh, A. [Southwest Research Inst., San Antonio, TX (United States). Center for Nuclear Waste Regulatory Analyses

    1994-05-01

    A laboratory characterization of the Apache Leap tuff joints under cyclic pseudostatic and dynamic loads has been undertaken to obtain a better understanding of dynamic joint shear behavior and to generate a complete data set that can be used for validation of existing rock-joint models. Study has indicated that available methods for determining joint roughness coefficient (JRC) significantly underestimate the roughness coefficient of the Apache Leap tuff joints, that will lead to an underestimation of the joint shear strength. The results of the direct shear tests have indicated that both under cyclic pseudostatic and dynamic loadings the joint resistance upon reverse shearing is smaller than that of forward shearing and the joint dilation resulting from forward shearing recovers during reverse shearing. Within the range of variation of shearing velocity used in these tests, the shearing velocity effect on rock-joint behavior seems to be minor, and no noticeable effect on the peak joint shear strength and the joint shear strength for the reverse shearing is observed.

  3. Radon exhalation from granitic rocks

    International Nuclear Information System (INIS)

    Del Claro, Flávia; Paschuk, Sergei A.; Corrêa, Janine N.; Mazer, Wellington; Narloch, Danielle Cristine; Martin, Aline Cristina; Denyak, Valeriy

    2017-01-01

    Naturally occurring radionuclides such as radon ( 222 Rn), its decay products and other elements from the radioactive series of uranium ( 238 U and 235 U) and thorium ( 232 Th) are an important source of human exposure to natural radioactivity. The worldwide evaluation of health radiobiological effects and risks from population exposure to natural radionuclides is a growing concern. About 50% of personal radiation annual dose is related to radionuclides such as radon ( 222 Rn), thoron ( 220 Rn), radium ( 226 Ra), thorium ( 232 Th) and potassium ( 40 K), which are present in modern materials commonly used in construction of dwellings and buildings. The radioactivity of marbles and granites is of big concern since under certain conditions the radioactivity levels of these materials can be hazardous to the population and require the implementation of mitigation procedures. Present survey of the 222 Rn and 220 Rn activity concentration liberated in the air was performed using commercialized Brazilian granite rocks at national market as well as exported to other countries. The 222 Rn and 220 Rn measurements were performed using the AlphaGUARD instant monitor and RAD7 detector, respectively. This study was performed at the Applied Nuclear Physics Laboratory of the Federal University of Technology – Paraná (UTFPR). Obtained results of radon concentration activity in air exhaled studied samples of granites varied from 3±1 Bq/m 3 to 2087±19 Bq/m 3 , which shows that some samples of granitic rocks represent rather elevated health risk the population. (author)

  4. Aespoe hard rock laboratory Sweden

    International Nuclear Information System (INIS)

    1992-01-01

    The aim of the new Aespoe hard rock laboratory is to demonstrate state of the art of technology and evaluation methods before the start of actual construction work on the planned deep repository for spent nuclear fuel. The nine country OECD/NEA project in the Stripa mine in Sweden has been an excellent example of high quality international research co-operation. In Sweden the new Aespoe hard rock laboratory will gradually take over and finalize this work. SKB very much appreciates the continued international participation in Aespoe which is of great value for the quality efficiency, and confidence in this kind of work. We have invited a number of leading experts to this first international seminar to summarize the current state of a number of key questions. The contributions show the great progress that has taken place during the years. The results show that there is a solid scientific basis for using this knowledge on site specific preparation and work on actual repositories. (au)

  5. Chemical Activation of the Hypoxia-Inducible Factor Reversibly Reduces Tendon Stem Cell Proliferation, Inhibits Their Differentiation, and Maintains Cell Undifferentiation

    Directory of Open Access Journals (Sweden)

    Alessandra Menon

    2018-01-01

    Full Text Available Adult stem cell-based therapeutic approaches for tissue regeneration have been proposed for several years. However, adult stem cells are usually limited in number and difficult to be expanded in vitro, and they usually tend to quickly lose their potency with passages, as they differentiate and become senescent. Culturing stem cells under reduced oxygen tensions (below 21% has been proposed as a tool to increase cell proliferation, but many studies reported opposite effects. In particular, cell response to hypoxia seems to be very stem cell type specific. Nonetheless, it is clear that a major role in this process is played by the hypoxia inducible factor (HIF, the master regulator of cell response to oxygen deprivation, which affects cell metabolism and differentiation. Herein, we report that a chemical activation of HIF in human tendon stem cells reduces their proliferation and inhibits their differentiation in a reversible and dose-dependent manner. These results support the notion that hypoxia, by activating HIF, plays a crucial role in preserving stem cells in an undifferentiated state in the “hypoxic niches” present in the tissue in which they reside before migrating in more oxygenated areas to heal a damaged tissue.

  6. Field study of the comparative efficacy of gamithromycin and tulathromycin for the treatment of undifferentiated bovine respiratory disease complex in beef feedlot calves.

    Science.gov (United States)

    Torres, Siddartha; Thomson, Dan U; Bello, Nora M; Nosky, Bruce J; Reinhardt, Chris D

    2013-06-01

    To compare the efficacy of gamithromycin with that of tulathromycin for the treatment of undifferentiated bovine respiratory disease complex (BRDC) in feedlot calves. 1,049 weaned crossbred beef calves. At each of 6 feedlots, newly arrived calves with BRDC were administered a single dose of gamithromycin (6.0 mg/kg, SC; n = 523) or tulathromycin (2.5 mg/kg, SC; 526). Case-fatality and BRDC retreatment rates during the first 120 days after treatment, final body weight, and average daily gain (ADG), were compared between treatments. At 2 feedlots, calves were assigned clinical scores for 10 days after treatment to determine recovery rates for each treatment. Bioequivalence limits for gamithromycin and tulathromycin were calculated for outcomes for which there was no significant difference between treatments. Mean BRDC retreatment rate (17.7%) for calves administered gamithromycin was greater than that (9.0%) for calves administered tulathromycin. Mean case-fatality rate, final body weight, ADG, and clinical score 10 days after treatment did not differ significantly between treatments. Limits for mean differences within which gamithromycin was bioequivalent to tulathromycin were ± 2.4% for case-fatality rate, ± 13 kg for final body weight, and ± 0.1 kg/d for ADG. Calves administered gamithromycin had a higher BRDC retreatment rate than did calves administered tulathromycin; otherwise, the clinical efficacy did not differ between the 2 treatments for the treatment of BRDC in feedlot calves.

  7. Efficacy of a florfenicol-flunixin meglumine combination product versus tulathromycin or ceftiofur crystalline free acid for the treatment of undifferentiated fever in feedlot calves.

    Science.gov (United States)

    Hannon, Sherry J; Perrett, Tye; Wildman, Brian K; Schunicht, Oliver C; Vogstad, Amanda R; Fenton, R Kent; Borciaga-Robles, Luis O; Pollock, Colleen M; Jim, G Kee; Berg, Janice; Booker, Calvin W

    2009-01-01

    In this field trial, a new combination product containing florfenicol and flunixin meglumine (FLOR-FM) was compared with commercially available products that contained only tulathromycin (TULA) or ceftiofur crystalline free acid (CCFA) for the treatment of undifferentiated fever (UF; rectal temperature >/=105.0 degrees F) in beef calves that received long-acting oxytetracycline at feedlot arrival. The overall mortality rate of the FLOR FM group (2.0%) was significantly (P less than .050) lower than the rates in the TULA and CCFA groups (10.0% and 20.0%, respectively; 50 animals/group), even though the first UF relapse rate of the FLOR FM group was significantly (P less than .050) higher than that of the TULA group. In the FLOR FM group, this resulted in per-animal economic advantages of Can$46.23 (versus TULA) and Can$108.77 (versus CCFA) based on equal costs for initial UF therapy. These results demonstrate that it is more cost-effective to administer FLOR FM than TULA or CCFA for initial UF therapy in feedlot calves at high risk for bovine respiratory disease that receive metaphylactic long-acting oxytetracycline at feedlot arrival.

  8. A case of a resected benign myxoma-like hemorrhagic cyst, which later recurred as undifferentiated pleomorphic sarcoma in the left atrium.

    Science.gov (United States)

    Kim, Eunju; Choi, Seo-Won; Min, Daniel; Kim, Sang Hoon; Yang, Woo-In; Moon, Jae Youn; Sung, Jung Hoon; Kim, In Jai; Lim, Sang-Wook; Cha, Dong-Hun; Moon, Byung; Cho, Sang-Ho; Kim, Won-Jang

    2017-04-01

    An intracardiac cystic mass is a rare type of mass found in the left atrium. The differential diagnosis of an intracardiac cystic mass includes hydatid cysts, bronchogenic cysts, intracardiac varices, and hemorrhages in some tumor types, including myxoma. We present the case of a 68-year-old woman who presented with episodic dyspnea. Transthoracic echocardiography (TTE) revealed the presence of a left atrial mass mimicking myxoma. However, in postoperative findings, it was determined that the mass was actually a hemorrhagic cyst. Eighteen months later, the patient presented with recurrent exertional dyspnea and TTE revealed the recurrence of a left atrial mass. Computed tomography showed that the mass extended into the right atrium, inferior vena cava, and coronary sinus. After re-operation, the final histological diagnosis was determined to be an undifferentiated pleomorphic sarcoma in the left atrium. An intracardiac hemorrhagic cyst was suspected during the operation of a benign-looking LA mass. As such, we recommend that other rare etiologies be considered and more biopsies be performed when possible.

  9. The osteogenic response of undifferentiated human mesenchymal stem cells (hMSCs) to mechanical strain is inversely related to body mass index of the donor.

    Science.gov (United States)

    Friedl, Gerald; Windhager, Reinhard; Schmidt, Helena; Aigner, Reingard

    2009-08-01

    While the importance of physical factors in the maintenance and regeneration of bone tissue has been recognized for many years and the mechano-sensitivity of bone cells is well established, there is increasing evidence that body fat constitutes an independent risk factor for complications in bone fracture healing and aseptic loosening of implants. Although mechanical causes have been widely suggested, we hypothesized that the osteogenic mechano-response of human mesenchymal stem cells (hMSCs) may be altered in obese patients. We determined the phenotypic and genotypic response of undifferentiated hMSCs of 10 donors to cyclic tensile strain (CTS) under controlled in vitro conditions and analyzed the potential relationship relevant to the donor's anthropomorphometric and biochemical parameters related to donor's fat and bone metabolism. The osteogenic marker genes were all statistically significantly upregulated by CTS, which was accompanied by a significant increase in cell-based ALP activity. Linear correlation analysis revealed that there was a significant correlation between phenotypic CTS response and the body mass index of the donor (r = -0.91, p < 0.001) and phenotypic CTS response was also significantly related to leptin levels (r = -0.68) and estradiol levels (r = 0.67) within the bone marrow microenvironment of the donor. Such an upstream imprinting process mediated by factors tightly related to the donor's fat metabolism, which hampers the mechanosensitivity of hMSCs in obese patients, may be of pathogenetic relevance for the complications associated with obesity that are seen in orthopedic surgery.

  10. [A Case of Resection for Lymph Node Recurrence around the Inferior Vena Cava after Radical Surgery of Undifferentiated Carcinoma of the Pancreatic Head Region].

    Science.gov (United States)

    Kubo, Masahiko; Yamada, Daisaku; Eguchi, Hidetoshi; Iwagami, Yoshifumi; Noda, Takehiro; Asaoka, Tadafumi; Wada, Hiroshi; Kawamoto, Kouichi; Gotoh, Kunihito; Kobayashi, Shogo; Mori, Masaki; Doki, Yuichiro

    2018-02-01

    A 60-year-old man underwent palliative surgery with a diagnosis of unresectable cancer, and he visited our hospital for further treatment. Since the cancer was unresectable and multiple hepatic tumors were revealed in CT images that were not metastases, we decided to perform curative surgery for the pancreatic cancer accompanied by partial liver invasion. Pancreaticoduodenectomy plus partial hepatectomy were performed, and 2 tumors were detected in the resected specimen: one in the pancreas-duodenum region and a submucosal tumor in the duodenum bulb. The large tumor that occupied the pancreasduodenum region was histologically diagnosed as an undifferentiated carcinoma, and the duodenal submucosal tumor was consistent with findings of a poorly differentiated adenocarcinoma. Two years after surgery, CT examination revealed a mass extending into the inferior vena cava(IVC)from near the right renal vein. We eventually diagnosed lymph node recurrence with tumor thrombosis inthe IVC and started chemotherapy(FOLFIRINOX). After the tumor decreased, we performed salvage surgery involving resection of the lymph node, thrombectomy, and right nephrectomy. The tumor revealed atypical cells in the region of thrombosis, and the pathological findings were not in conflict with the findings of metastases from pancreatic cancer 2 years prior. After the treatment, chemotherapy was administered and he survived without any recurrence for 15 months after surgery.

  11. Panuveíte em artrite indiferenciada HLA-B27 positiva Panuveitis in HLA-B27 positive undifferentiated arthritis

    Directory of Open Access Journals (Sweden)

    Mário Sérgio Ferreira Santos

    2008-10-01

    Full Text Available Entre os vários tipos de inflamação ocular associados às doenças reumatológicas, a uveíte anterior é particularmente comum nas espondiloartropatias, em especial quando associada à presença do genótipo HLA-B27. Relatou-se o caso de um paciente com artrite indiferenciada HLA-B27 positivo, complicado com panuveíte e vasculite da retina, refratária ao tratamento imunossupressor tradicional, que obteve boa resposta clínica ao uso de anti-TNF-alfa.Among the several types of ocular inflammation associated to the rheumatic diseases, anterior uveitis is particularly common in the spondyloarthropathies, especially when associated to the presence of the HLA-B27 genotype. We report the case of HLA-B27 positive patient with undifferentiated arthritis, complicated with panuveitis and retinal vasculitis, that was refractory to the traditional imunossupressive treatment, and had a good clinical response with anti-TNF-alpha therapy.

  12. A Trp53fl/flPtenfl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging.

    Directory of Open Access Journals (Sweden)

    Marisa R Buchakjian

    Full Text Available Genetic mouse models of soft tissue sarcoma provide critical insights into disease pathophysiology, which are oftentimes unable to be extracted from human tumor samples or xenograft models. In this study we describe a mouse model of soft tissue sarcoma mediated by adenoviral-Cre recombinase injection into Trp53fl/fl/Ptenfl/fl lox-stop-lox luciferase mice. Injection of adenovirus expressing Cre recombinase, either subcutaneously or intramuscularly in two experimental groups, results in viral infection and gene recombination with 100% penetrance within the first 24 hours following injection. Luciferase expression measured by real-time bioluminescence imaging increases over time, with an initial robust increase following viral injection, followed by a steady rise over the next several weeks as primary tumors develop and grow. Intramuscular injections were more commonly associated with evidence of systemic viral distribution than subcutaneous injections. All mice developed soft tissue sarcomas at the primary injection site, with histological examination identifying 93% of tumors as invasive pleomorphic sarcomas based on microscopic morphology and immunohistochemical expression of sarcoma markers. A lymphocytic infiltrate was present in 64% of the sarcomas in this immunocompetent model and 71% of tumors expressed PD-L1. This is the first report of a viral-Cre mediated Trp53/Pten mouse model of undifferentiated pleomorphic sarcoma. The bioluminescence imaging feature, along with high penetrance of the model and its immunological characteristics, makes it suited for pre-clinical studies of soft tissue sarcoma.

  13. An Item Analysis of the French Version of the Test for Reception of Grammar Among Children and Adolescents With Down Syndrome or Intellectual Disability of Undifferentiated Etiology.

    Science.gov (United States)

    Facon, Bruno; Magis, David

    2016-10-01

    An item analysis of Bishop's (1983) Test for Reception of Grammar (TROG) in its French version (F-TROG; Lecocq, 1996) was conducted to determine whether the difficulty of items is similar for participants with or without intellectual disability (ID). In Study 1, responses to the 92 F-TROG items by 55 participants with Down syndrome (DS), 55 with ID of undifferentiated etiology (UND), and 55 typical children (TYP) matched on their F-TROG total score were compared using the transformed item difficulties method, a statistical approach designed to detect differential item functioning (DIF) between groups. In Study 2, an additional comparison involving 526 TYP participants and 526 participants with UND was conducted to increase the statistical power of the analysis. The difficulty of items was highly similar whatever the sample size or clinical status of participants. Fewer than 3.5% of the items were flagged as showing DIF. Tests such as the TROG can be used with confidence in clinical practice as well as in research studies comparing participants with or without ID. Methods designed for investigating potential internal test bias-such as done here-should be more regularly employed in the developmental disability field to affirm the absence of DIF.

  14. Pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma of the scrotum in a patient presenting as fournier gangrene: a case report.

    Science.gov (United States)

    Guo, Juan; Zhou, Shengmei; Rao, Nagesh P; Pez, Gholam H

    2010-10-01

    Pleomorphic malignant fibrous histiocytoma (MFH), also known as undifferentiated high-grade pleomorphic sarcoma according to the latest World Health Organization classification, is a diagnosis of exclusion and extremely rare in adult scrotal/paratesticular region. Clinical presentation of scrotal/paratesticular pleomorphic MFH is usually a painless and gradual scrotal swelling. We report a case of scrotal MFH in a 63-year-old man who presented as Fournier gangrene after 10-month painful scrotal swelling and multiple procedures. The specimen of emergent debridement was submitted for pathologic and bacteriologic examination. Microscopically, the lesion had marked architectural and cytologic pleomorphism. The neoplastic cells were positive for vimentin, but negative for all lineage-specific markers. Fluorescence in-situ hybridization showed an aneuploid karyotype and negative results for lipomatous tumor abnormalities. Bacterial cultures of the specimen showed extensive growth of virulent polymicrobes. The diagnosis of scrotal/paratesticular pleomorphic MFH with concurrent Fournier gangrene was made. Thoracic computed tomography scan showed bilateral multiple pulmonary nodules. The patient died 1 month later.

  15. Electrical resistivities of rocks from Chalk River

    International Nuclear Information System (INIS)

    Katsube, T.J.; Hume, J.P.

    1989-01-01

    Bulk rock resistivity and bulk surface resistivity measurements have been obtained for 40 gneissic rock samples from Chalk River, Ontario. Though bulk rock resistivity is a function of pore structure, pore-fluid resistivity and pore-surface resistivity, the amount of data documented for pore-surface resistivity is small compared to that for pore structure and pore-fluid resistivity. This study indicates that pore-surface resistivity has a significant effect on bulk rock resistivity. It is important that this fact be considered when interpreting resistivity data obtained by geophysical methods. In addition, a group of mafic gneiss samples had pore-surface resistivity values that were much lower than those reported for clays, glass beads or petroleum reservoir rocks. This is thought to be due to metallic minerals lining the pore walls. Other rock samples collected from the same area showed pore-surface resistivity value similar to those reported in the literature

  16. Chemical buffering capacity of clay rock

    International Nuclear Information System (INIS)

    Beaucaire, C.; Pearson, F.J.; Gautschi, A.

    2004-01-01

    The long-term performance of a nuclear waste repository is strongly dependent on the chemical properties of the host rock. The host rock establishes the chemical environment that determines such important performance attributes as radionuclide solubilities from the waste and the transport rates from the repository to the accessible environment. Clay-rich rocks are especially favourable host rocks because they provide a strong buffering capacity to resist chemical changes prompted either internally, by reactions of the waste itself and emplacement materials, or externally, by changes in the hydrologic systems surrounding the host rock. This paper will focus on three aspects of the stability of clay-rich host rocks: their ability to provide pCO 2 and redox buffering, and to resist chemical changes imposed by changes in regional hydrology and hydro-chemistry. (authors)

  17. Assessment Quality in Tertiary Education: An Integrative Literature Review

    OpenAIRE

    Gerritsen-van Leeuwenkamp, Karin; Joosten-ten Brinke, Desirée; Kester, Liesbeth

    2018-01-01

    In tertiary education, inferior assessment quality is a problem that has serious consequences for students, teachers, government, and society. A lack of a clear and overarching conceptualization of assessment quality can cause difficulties in guaranteeing assessment quality in practice. Thus, the aim of this study is to conceptualize assessment quality in tertiary education by providing an overview of the assessment quality criteria, their influences, the evaluation of the assessment quality ...

  18. Challenges with Tertiary-Level Mechatronic Fluid Power

    DEFF Research Database (Denmark)

    Dransfield, Peter; Conrad, Finn

    1996-01-01

    As authors we take the view that mechatronics, as it relates to fluid power, has three levels which we designate as primary, secondary and tertiary. A brief review of the current status of fluid power, hydraulic and pneumatic, and of electronic control of it is presented and discussed. The focus...... is then on tertiary-level mechatronic fluid power and the challenges to it being applied successfully....

  19. EXPLORING THE TERTIARY EFL STUDENTS' ACADEMIC WRITING COMPETENCIES

    OpenAIRE

    Aunurrahman Aunurrahman; Fuad Abdul Hamied Hamied; Emi Emilia

    2017-01-01

    For tertiary English as a Foreign Language (EFL) students, academic writing is not an easy task. It requires knowledge of the academic writing genres with their particular linguistic features. Moreover, academic writing demands good critical thinking. This research aims to explore the students' academic writing competencies that also focus on critical thinking. The research involved thirty-six first-year tertiary EFL students from a regular class of a private university in Pontianak, West Kal...

  20. Emergency peripartum hysterectomy: The experience of a tertiary referral hospital

    OpenAIRE

    Y. Mesbah; A. Ragab; E. Fialla; R. Barakat; A. Badawy; Ahmed Ragab

    2013-01-01

    Objective(s): The aim of this study was to review the frequency, indication, associated risk factors, rates of maternal morbidity and mortality as well as neonatal outcome after emergency peripartum hysterectomy at a tertiary care referral hospital. Study design: A retrospective observational study carried out from November 2008 to 2011. Patients and methods: The study comprised of 29 patients at Mansoura University Hospitals a tertiary referral hospital Egypt. Frequency, indications, a...

  1. Physical Properties Data for Rock Salt

    Science.gov (United States)

    1981-01-01

    foreign substances, such as oil . Other characteristics of Rock salt is a coarsely crystalline, sedimentary rock rock salt, specifically porosity and...225Permian """ 280 - , Pennsyl vani an-. ’, ~320---.. Mississippian 345 Paleozoic Devonian 395- . Silurian 430... Silurian salt-bearing Salina Formation of Michi- well into the Gulf of Mexico to the Sigsbee knolls, which gan, northern Ohio, Ontario, New York

  2. Response of rocks to large stresses

    International Nuclear Information System (INIS)

    Schock, R.N.

    1976-01-01

    To predict the dimensions and characteristics of impact- and explosion-induced craters, one must know the equation of state of the rocks in which the crater is formed. Recent experimental data shed light upon inelastic processes that influence the stress/strain behavior of rocks. We examine these data with a view to developing models that could be used in predicting cratering phenomena. New data is presented on the volume behavior of two dissimilar rocks subjected to tensile stresses

  3. Reappraisal of hydrocarbon biomarkers in Archean rocks.

    Science.gov (United States)

    French, Katherine L; Hallmann, Christian; Hope, Janet M; Schoon, Petra L; Zumberge, J Alex; Hoshino, Yosuke; Peters, Carl A; George, Simon C; Love, Gordon D; Brocks, Jochen J; Buick, Roger; Summons, Roger E

    2015-05-12

    Hopanes and steranes found in Archean rocks have been presented as key evidence supporting the early rise of oxygenic photosynthesis and eukaryotes, but the syngeneity of these hydrocarbon biomarkers is controversial. To resolve this debate, we performed a multilaboratory study of new cores from the Pilbara Craton, Australia, that were drilled and sampled using unprecedented hydrocarbon-clean protocols. Hopanes and steranes in rock extracts and hydropyrolysates from these new cores were typically at or below our femtogram detection limit, but when they were detectable, they had total hopane (rock) and total sterane (rock) concentrations comparable to those measured in blanks and negative control samples. In contrast, hopanes and steranes measured in the exteriors of conventionally drilled and curated rocks of stratigraphic equivalence reach concentrations of 389.5 pg per gram of rock and 1,039 pg per gram of rock, respectively. Polycyclic aromatic hydrocarbons and diamondoids, which exceed blank concentrations, exhibit individual concentrations up to 80 ng per gram of rock in rock extracts and up to 1,000 ng per gram of rock in hydropyrolysates from the ultraclean cores. These results demonstrate that previously studied Archean samples host mixtures of biomarker contaminants and indigenous overmature hydrocarbons. Therefore, existing lipid biomarker evidence cannot be invoked to support the emergence of oxygenic photosynthesis and eukaryotes by ∼ 2.7 billion years ago. Although suitable Proterozoic rocks exist, no currently known Archean strata lie within the appropriate thermal maturity window for syngenetic hydrocarbon biomarker preservation, so future exploration for Archean biomarkers should screen for rocks with milder thermal histories.

  4. Nature and origin of secondary mineral coatings on volcanic rocks of the Black Mountain, Stonewall Mountain, and Kane Springs Wash volcanic centers, southern, Nevada

    Science.gov (United States)

    Taranik, James V.; Hsu, Liang C.; Spatz, David M.; Chenevey, Michael J.

    1989-10-01

    The following subject areas are covered: (1) genetic, spectral, and LANDSAT Thematic Mapper imagery relationship between desert varnish and tertiary volcanic host rocks, southern Nevada; (2) reconnaissance geologic mapping of the Kane Springs Wash Volcanic Center, Lincoln County, Nevada, using multispectral thermal infrared imagery; (3) interregional comparisons of desert varnish; and (4) airborne scanner (GERIS) imagery of the Kane Springs Wash Volcanic Center, Lincoln County, Nevada.

  5. Nature and origin of secondary mineral coatings on volcanic rocks of the Black Mountain, Stonewall Mountain, and Kane Springs Wash volcanic centers, southern, Nevada

    Science.gov (United States)

    Taranik, James V.; Hsu, Liang C.; Spatz, David M.; Chenevey, Michael J.

    1989-01-01

    The following subject areas are covered: (1) genetic, spectral, and LANDSAT Thematic Mapper imagery relationship between desert varnish and tertiary volcanic host rocks, southern Nevada; (2) reconnaissance geologic mapping of the Kane Springs Wash Volcanic Center, Lincoln County, Nevada, using multispectral thermal infrared imagery; (3) interregional comparisons of desert varnish; and (4) airborne scanner (GERIS) imagery of the Kane Springs Wash Volcanic Center, Lincoln County, Nevada.

  6. Hopi and Anasazi Alignments and Rock Art

    Science.gov (United States)

    Bates, Bryan C.

    The interaction of light and shadow on ancestral Puebloan rock art, or rock art demarcating sunrise/set horizon points that align with culturally significant dates, has long been assumed to be evidence of "intentional construct" for marking time or event by the native creator. However, anthropological rock art research requires the scientific control of cultural time, element orientation and placement, structure, and association with other rock art elements. The evaluation of five exemplars challenges the oft-held assumption that "if the interaction occurs, it therefore supports intentional construct" and thereby conveys meaning to the native culture.

  7. Regulation of ROCK Activity in Cancer

    Science.gov (United States)

    Morgan-Fisher, Marie; Wewer, Ulla M.

    2013-01-01

    Cancer-associated changes in cellular behavior, such as modified cell-cell contact, increased migratory potential, and generation of cellular force, all require alteration of the cytoskeleton. Two homologous mammalian serine/threonine kinases, Rho-associated protein kinases (ROCK I and II), are key regulators of the actin cytoskeleton acting downstream of the small GTPase Rho. ROCK is associated with cancer progression, and ROCK protein expression is elevated in several types of cancer. ROCKs exist in a closed, inactive conformation under quiescent conditions, which is changed to an open, active conformation by the direct binding of guanosine triphosphate (GTP)–loaded Rho. In recent years, a number of ROCK isoform-specific binding partners have been found to modulate the kinase activity through direct interactions with the catalytic domain or via altered cellular localization of the kinases. Thus, these findings demonstrate additional modes to regulate ROCK activity. This review describes the molecular mechanisms of ROCK activity regulation in cancer, with emphasis on ROCK isoform-specific regulation and interaction partners, and discusses the potential of ROCKs as therapeutic targets in cancer. PMID:23204112

  8. Rock breaking methods to replace blasting

    Science.gov (United States)

    Zhou, Huisheng; Xie, Xinghua; Feng, Yuqing

    2018-03-01

    The method of breaking rock by blasting has a high efficiency and the cost is relatively low, but the associated vibration, flyrock, production of toxic gases since the 1970’s, the Western developed countries began to study the safety of breaking rock. This paper introduces different methods and their progress to safely break rock. Ideally, safe rock breaking would have little vibration, no fly stone, and no toxic gases, which can be widely used in municipal engineering, road excavation, high-risk mining, quarrying and complex environment.

  9. Estética del rock

    OpenAIRE

    Rey, Sebastián

    2014-01-01

    El objetivo del presente artículo es el de analizar la estética del Rock en términos de la experiencia que ofrece este género musical. En primer lugar se construirá una relación entre el Nacimiento de la tragedia de Nietzsche y el surgimiento del Rock, bajo la premisa de que el origen del Rock es eminentemente dionisíaco; luego se mostrará una forma de la experiencia en la vida cotidiana de quien escucha Rock, en donde se da cuenta de la necesidad de expresar los sentimientos de placer y disp...

  10. Igneous rocks formed by hypervelocity impact

    Science.gov (United States)

    Osinski, Gordon R.; Grieve, Richard A. F.; Bleacher, Jacob E.; Neish, Catherine D.; Pilles, Eric A.; Tornabene, Livio L.

    2018-03-01

    Igneous rocks are the primary building blocks of planetary crusts. Most igneous rocks originate via decompression melting and/or wet melting of protolith lithologies within planetary interiors and their classification and compositional, petrographic, and textural characteristics, are well-studied. As our exploration of the Solar System continues, so too does the inventory of intrusive and extrusive igneous rocks, settings, and processes. The results of planetary exploration have also clearly demonstrated that impact cratering is a ubiquitous geological process that has affected, and will continue to affect, all planetary objects with a solid surface, whether that be rock or ice. It is now recognized that the production of igneous rocks is a fundamental outcome of hypervelocity impact. The goal of this review is to provide an up-to-date synthesis of our knowledge and understanding of igneous rocks formed by hypervelocity impact. Following a brief overview of the basics of the impact process, we describe how and why melts are generated during impact events and how impact melting differs from endogenic igneous processes. While the process may differ, we show that the products of hypervelocity impact can share close similarities with volcanic and shallow intrusive igneous rocks of endogenic origin. Such impact melt rocks, as they are termed, can display lobate margins and cooling cracks, columnar joints and at the hand specimen and microscopic scale, such rocks can display mineral textures that are typical of volcanic rocks, such as quench crystallites, ophitic, porphyritic, as well as features such as vesicles, flow textures, and so on. Historically, these similarities led to the misidentification of some igneous rocks now known to be impact melt rocks as being of endogenic origin. This raises the question as to how to distinguish between an impact versus an endogenic origin for igneous-like rocks on other planetary bodies where fieldwork and sample analysis may not

  11. Rock Art of the Greater Southwest

    Science.gov (United States)

    Krupp, Edwin C.

    Archaeoastronomical studies in the American Southwest began in 1955 with recognition of what seemed to be pictorial eyewitness records of the Crab supernova of 1054 AD In time, reports of seasonally significant light-and-shadow effects on rock art and associations of rock art with astronomical alignments also emerged. Most astronomical rock art studies remained problematic, however, because criteria for proof of ancient intent were elusive. Disciplined methods for assessing cultural function were difficult to develop, but review of ethnographically documented astronomical traditions of California Indians and of Indians in the American Southwest subsequently increased confidence in the value of some astronomical rock art initiatives.

  12. Thermal Inertia of Rocks and Rock Populations and Implications for Landing Hazards on Mars

    Science.gov (United States)

    Golombek, M. P.; Jakosky, B. M.; Mellon, M. T.

    2001-01-01

    Rocks represent an obvious potential hazard to a landing spacecraft. They also represent an impediment to rover travel and objects of prime scientific interest. Although Mars Orbiter Camera (MOC) images are of high enough resolution to distinguish the largest rocks (an extremely small population several meters diameter or larger), traditionally the abundance and distribution of rocks on Mars have been inferred from thermal inertia and radar measurements, our meager ground truth sampling of landing sites, and terrestrial rock populations. In this abstract, we explore the effective thermal inertia of rocks and rock populations, interpret the results in terms of abundances and populations of potentially hazardous rocks, and conclude with interpretations of rock hazards on the Martian surface and in extremely high thermal inertia areas.

  13. Medical neglect at a tertiary paediatric hospital.

    Science.gov (United States)

    Parmeter, Julia; Tzioumi, Dimitra; Woolfenden, Susan

    2018-03-01

    Medical neglect is under-researched and the extent of the problem in Australia is unknown. We conducted a review of the referrals for medical neglect to the Child Protection Unit (CPU) at a tertiary children's hospital in Sydney over a 5 years period, from 2011 to 2016, to determine what medical conditions are being referred, the reason for the medical neglect concern and whether cases are managed in line with American Academy of Pediatrics (AAP) guideline on medical neglect. 61 cases of medical neglect were identified, constituting 4.1% of all referrals to the Child Protection Unit for physical abuse and neglect. There was a wide variety of medical conditions. Most were chronic medical conditions (87%). The top two medical conditions were chronic and complex multi-system disorders (37.7%) and endocrine disorders (18%). The majority of medical neglect were related to concerns that the caregivers were unwilling to follow medical advice (45.9%) or unable to provide necessary medical care (26.2%). In line with the AAP guideline on medical neglect, all cases were managed by addressing communication difficulties (100%) and resource issues were addressed in 80% of cases. A report to statutory child protection agencies was made in 50% of cases. Directly observed therapy and medical contracts were used in 30% and 26% of cases. We conclude that children with chronic medical conditions may be at risk of medical neglect. Communication difficulties were a factor in all cases. Statutory agency intervention is often required. Copyright © 2018 Elsevier Ltd. All rights reserved.

  14. CLINICAL SPECTRUM OF HYPONATRAEMIA IN TERTIARY CENTRE

    Directory of Open Access Journals (Sweden)

    Suresh Chincholi

    2017-02-01

    Full Text Available BACKGROUND Hyponatraemia is defined as a serum sodium level less than 135 mEq/L. High mortality among the patients of hyponatraemia is secondary to the underlying medical condition. Frequency is high in elderly patients. MATERIALS AND METHODS The study was conducted at a tertiary care centre (Basaveshwar Teaching and General Hospital, Gulbarga, from the period September 2014 to August 2016. These patients were evaluated for the underlying cause of hyponatraemia, which included detailed history and physical examination followed by appropriate laboratory investigations. Patients were followed up till the hyponatraemia was treated or patients were discharged from the hospital. RESULTS 100 patients of hyponatraemia were included in the study. 46% of the patients were asymptomatic. 33% patients had lethargy, 28% patients had postural dizziness and 19% had abnormal behaviour. Overall incidence of hyponatraemia was 4.58% in the hospitalised population, whereas its incidence in ICU patients was 22.4%. Twelve patients of symptomatic severe hyponatraemia were treated with hypertonic saline infusion, 25% patients were given loop diuretics with oral supplementation of sodium chloride for free water excretion in SIADH cases and in patients with hypervolaemia, hyponatraemia, fluid restriction was advised to 44 patients, oral supplementation of sodium chloride was given in 36 patients and 64 patients received normal saline. 9 patients included in the study died, 5 of which had advanced cirrhosis of liver as underlying cause. One patient developed Osmotic Demyelination Syndrome (ODS. CONCLUSION The possible cause of hyponatraemia should always be sought as outcome in severe hyponatraemia is governed by aetiology, and not by the serum sodium level. Treatment of severe symptomatic hyponatraemia with hypertonic saline is safe if recommendation for the rate of correction of hyponatraemia is strictly followed.

  15. Tertiary lymphoid organs in Takayasu Arteritis

    Directory of Open Access Journals (Sweden)

    Marc eClement

    2016-04-01

    Full Text Available Objective: The role of B cells in the pathogenesis of Takayasu arteritis (TA is controversial. We aimed to study the presence of tertiary lymphoid organs (TLOs in the aortic wall of TA patients.Methods: Hematoxylin and eosin–stained sections from aorta specimens from patients with TA were screened for TLOs. The presence of B cell aggregates (CD20, follicular dendritic cells (FDCs, CD21, and high endothelial venules (HEVs, PNAd was investigated by immunohistochemistry. Immune cells from the adventitial layer of one patient were characterized by flow cytometry. Demographic, medical history, laboratory, imaging, treatment and follow up data were extracted from medical records.Results: Aorta specimens from Bentall procedures were available from 7 patients (five female, aged 22 to 57 years with TA. Surgical treatment was performed at TA diagnosis (n=4 or at a median of 108 months [84-156] after TA diagnosis. Disease was active at surgery in four patients according to NIH score. B cell aggregates-TLOs containing HEVs were observed in the adventitia of all but one patient.. Of note, ectopic follicles containing CD21+ FDCs were found in all patients (4/4 with increased aortic FDG uptake before surgery but were absent in all but one patients (2/3 with no FDG uptake. In addition, flow cytometry analysis confirmed the accumulation of memory/germinal center–like B cells in the adventitial layer and showed the presence of antigen-experienced T follicular helper cells.Conclusion: Ectopic lymphoid neogenesis displaying functional features can be found in the aortic wall of a subset of patients with active TA. The function of these local B cell clusters on the pathogenesis of TA remains to be elucidated.

  16. Tertiary Lymphoid Organs in Takayasu Arteritis.

    Science.gov (United States)

    Clement, Marc; Galy, Adrien; Bruneval, Patrick; Morvan, Marion; Hyafil, Fabien; Benali, Khadija; Pasi, Nicoletta; Deschamps, Lydia; Pellenc, Quentin; Papo, Thomas; Nicoletti, Antonino; Sacre, Karim

    2016-01-01

    The role of B cells in the pathogenesis of Takayasu arteritis (TA) is controversial. We aimed to study the presence of tertiary lymphoid organs (TLOs) in the aortic wall of TA patients. Hematoxylin and eosin-stained sections from aorta specimens from patients with TA were screened for TLOs. The presence of B cell aggregates (CD20), follicular dendritic cells (FDCs, CD21), and high endothelial venules (HEVs, PNAd) was investigated by immunohistochemistry. Immune cells from the adventitial layer of one patient were characterized by flow cytometry. Demographic, medical history, laboratory, imaging, treatment, and follow-up data were extracted from medical records. Aorta specimens from Bentall procedures were available from seven patients (5 females, aged 22-57 years) with TA. Surgical treatment was performed at TA diagnosis (n = 4) or at a median of 108 months (84-156) after TA diagnosis. Disease was active at surgery in four patients according to NIH score. B cell aggregates-TLOs containing HEVs were observed in the adventitia of all but one patient. Of note, ectopic follicles containing CD21(+) FDCs were found in all patients (4/4) with increased aortic (18)F-fluoro-deoxyglucose (FDG) uptake before surgery but were absent in all but one patients (2/3) with no FDG uptake. In addition, flow cytometry analysis confirmed the accumulation of memory/germinal center-like B cells in the adventitial layer and showed the presence of antigen-experienced T follicular helper cells. Ectopic lymphoid neogenesis displaying functional features can be found in the aortic wall of a subset of patients with active TA. The function of these local B cell clusters on the pathogenesis of TA remains to be elucidated.

  17. Hydrogeomechanics for rock engineering: coupling subsurface hydrogeomechanical assessement and hydrogeotechnical mapping on fracturated rock masses

    OpenAIRE

    Meirinhos, João Miguel de Freitas

    2015-01-01

    The present work aims to achieve and further develop a hydrogeomechanical approach in Caldas da Cavaca hydromineral system rock mass (Aguiar da Beira, NW Portugal), and contribute to a better understanding of the hydrogeological conceptual site model. A collection of several data, namely geology, hydrogeology, rock and soil geotechnics, borehole hydraulics and hydrogeomechanics, was retrieved from three rock slopes (Lagoa, Amores and Cancela). To accomplish a comprehensive analysis and rock e...

  18. An investigation of rock fall and pore water pressure using LIDAR in Highway 63 rock cuts.

    Science.gov (United States)

    2014-07-01

    The purpose of this research work is compare LIDAR scanning measurements of rock fall with the natural changes in groundwater level to determining the effect of water pressures (levels) on rock fall. To collect the information of rock cut volume chan...

  19. Radon exhalation from granitic rocks

    Energy Technology Data Exchange (ETDEWEB)

    Del Claro, Flávia; Paschuk, Sergei A.; Corrêa, Janine N.; Mazer, Wellington; Narloch, Danielle Cristine; Martin, Aline Cristina [Universidade Tecnológica Federal do Paraná (UTFPR), Curitiba, PR (Brazil); Denyak, Valeriy, E-mail: flaviadelclaro@gmail.com, E-mail: spaschuk@gmail.com, E-mail: janine_nicolosi@hotmail.com, E-mail: denyak@gmail.com [Instituto de Pesquisa Pelé Pequeno Príncipe (IPPP), Curitiba, PR (Brazil)

    2017-07-01

    Naturally occurring radionuclides such as radon ({sup 222}Rn), its decay products and other elements from the radioactive series of uranium ({sup 238}U and {sup 235}U) and thorium ({sup 232}Th) are an important source of human exposure to natural radioactivity. The worldwide evaluation of health radiobiological effects and risks from population exposure to natural radionuclides is a growing concern. About 50% of personal radiation annual dose is related to radionuclides such as radon ({sup 222}Rn), thoron ({sup 220}Rn), radium ({sup 226}Ra), thorium ({sup 232}Th) and potassium ({sup 40}K), which are present in modern materials commonly used in construction of dwellings and buildings. The radioactivity of marbles and granites is of big concern since under certain conditions the radioactivity levels of these materials can be hazardous to the population and require the implementation of mitigation procedures. Present survey of the {sup 222}Rn and {sup 220}Rn activity concentration liberated in the air was performed using commercialized Brazilian granite rocks at national market as well as exported to other countries. The {sup 222}Rn and {sup 220}Rn measurements were performed using the AlphaGUARD instant monitor and RAD7 detector, respectively. This study was performed at the Applied Nuclear Physics Laboratory of the Federal University of Technology – Paraná (UTFPR). Obtained results of radon concentration activity in air exhaled studied samples of granites varied from 3±1 Bq/m{sup 3} to 2087±19 Bq/m{sup 3}, which shows that some samples of granitic rocks represent rather elevated health risk the population. (author)

  20. Computational Models of Rock Failure

    Science.gov (United States)

    May, Dave A.; Spiegelman, Marc

    2017-04-01

    Practitioners in computational geodynamics, as per many other branches of applied science, typically do not analyse the underlying PDE's being solved in order to establish the existence or uniqueness of solutions. Rather, such proofs are left to the mathematicians, and all too frequently these results lag far behind (in time) the applied research being conducted, are often unintelligible to the non-specialist, are buried in journals applied scientists simply do not read, or simply have not been proven. As practitioners, we are by definition pragmatic. Thus, rather than first analysing our PDE's, we first attempt to find approximate solutions by throwing all our computational methods and machinery at the given problem and hoping for the best. Typically this approach leads to a satisfactory outcome. Usually it is only if the numerical solutions "look odd" that we start delving deeper into the math. In this presentation I summarise our findings in relation to using pressure dependent (Drucker-Prager type) flow laws in a simplified model of continental extension in which the material is assumed to be an incompressible, highly viscous fluid. Such assumptions represent the current mainstream adopted in computational studies of mantle and lithosphere deformation within our community. In short, we conclude that for the parameter range of cohesion and friction angle relevant to studying rocks, the incompressibility constraint combined with a Drucker-Prager flow law can result in problems which have no solution. This is proven by a 1D analytic model and convincingly demonstrated by 2D numerical simulations. To date, we do not have a robust "fix" for this fundamental problem. The intent of this submission is to highlight the importance of simple analytic models, highlight some of the dangers / risks of interpreting numerical solutions without understanding the properties of the PDE we solved, and lastly to stimulate discussions to develop an improved computational model of

  1. On wettability of shale rocks.

    Science.gov (United States)

    Roshan, H; Al-Yaseri, A Z; Sarmadivaleh, M; Iglauer, S

    2016-08-01

    The low recovery of hydraulic fracturing fluid in unconventional shale reservoirs has been in the centre of attention from both technical and environmental perspectives in the last decade. One explanation for the loss of hydraulic fracturing fluid is fluid uptake by the shale matrix; where capillarity is the dominant process controlling this uptake. Detailed understanding of the rock wettability is thus an essential step in analysis of loss of the hydraulic fracturing fluid in shale reservoirs, especially at reservoir conditions. We therefore performed a suit of contact angle measurements on a shale sample with oil and aqueous ionic solutions, and tested the influence of different ion types (NaCl, KCl, MgCl2, CaCl2), concentrations (0.1, 0.5 and 1M), pressures (0.1, 10 and 20MPa) and temperatures (35 and 70°C). Furthermore, a physical model was developed based on the diffuse double layer theory to provide a framework for the observed experimental data. Our results show that the water contact angle for bivalent ions is larger than for monovalent ions; and that the contact angle (of both oil and different aqueous ionic solutions) increases with increase in pressure and/or temperature; these increases are more pronounced at higher ionic concentrations. Finally, the developed model correctly predicted the influence of each tested variable on contact angle. Knowing contact angle and therefore wettability, the contribution of the capillary process in terms of water uptake into shale rocks and the possible impairment of hydrocarbon production due to such uptake can be quantified. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Modelling the time-dependent rheological behaviour of heterogeneous brittle rocks

    Science.gov (United States)

    Xu, Tao; Tang, Chun-an; Zhao, Jian; Li, Lianchong; Heap, M. J.

    2012-06-01

    A 2-D numerical model for brittle creep and stress relaxation is proposed for the time-dependent brittle deformation of heterogeneous brittle rock under uniaxial loading conditions. The model accounts for material heterogeneity through a stochastic local failure stress field, and local material degradation using an exponential material softening law. Importantly, the model introduces the concept of a mesoscopic renormalization to capture the co-operative interaction between microcracks in the transition from distributed to localized damage. The model also describes the temporal and spatial evolution of acoustic emissions, including their size (energy released), in the medium during the progressive damage process. The model is first validated using previously published experimental data and is then used to simulate brittle creep and stress relaxation experiments. The model accurately reproduces the classic trimodal behaviour (primary, secondary and tertiary creep) seen in laboratory brittle creep (constant stress) experiments and the decelerating stress during laboratory stress relaxation (constant strain) experiments. Brittle creep simulations also show evidence of a 'critical level of damage' before the onset of tertiary creep and the initial stages of localization can be seen as early as the start of the secondary creep phase, both of which have been previously observed in experiments. Stress relaxation simulations demonstrate that the total amount of stress relaxation increases when the level of constant axial strain increases, also corroborating with previously published experimental data. Our approach differs from previously adopted macroscopic approaches, based on constitutive laws, and microscopic approaches that focus on fracture propagation. The model shows that complex macroscopic time-dependent behaviour can be explained by the small-scale interaction of elements and material degradation. The fact that the simulations are able to capture a similar time

  3. Modelling Spatial and Temporal Fault Zone Evolution in Basement Rocks

    Science.gov (United States)

    Lunn, R. J.; Willson, J. P.; Shipton, Z. K.

    2006-12-01

    There is considerable industrial interest in assessing the permeability of faults for the purpose of oil and gas production, deep well injection of waste liquids, underground storage of natural gas and disposal of radioactive waste. Prior estimation of fault hydraulic properties is highly error prone. Faults zones are formed through a complex interaction of mechanical, hydraulic and chemical processes and their permeability varies considerably over both space and time. Algorithms for predicting fault seal potential using throw and host rock property data exist for clay-rich fault seals but are contentious. In the case of crystalline rocks and sand-sand contacts, no such algorithms exist. In any case, the study of fault growth processes does not suggest that there is a clear or simple relationship between fault throw and the fault zone permeability. To improve estimates of fault zone permeability, it is important to understand the underlying hydro-mechanical processes of fault zone formation. In this research, we explore the spatial and temporal evolution of fault zones through development and application of a 2D hydro-mechanical finite element model. The development of fault zone damage is simulated perpendicular to the main slip surface using a fully coupled solution of Navier's equation for mechanical deformation and Darcy's Law/conservation of fluid mass for subsurface fluid flow. The model is applied to study development of fault zones in basement rocks, based on the conceptual model of S. J. Martell, J. Struct. Geol. 12(7):869-882, 1990. We simulate the evolution of fault zones from pre-existing joints and explore controls on the growth rate and locations of multiple splay fractures which link-up to form complex damage zones. We are the first researchers to successfully simulate the temporal and spatial evolution of multiple wing cracks, tertiary fracturing, antithetic fractures propagating into the compressive region, infill fracturing between faults and

  4. Sedimentary basin analysis and petroleum potential of the Cretaceous and Tertiary strata in Korea.

    Energy Technology Data Exchange (ETDEWEB)

    Son, Jin-Dam; Kwak, Young-Hoon; Bong, Pil-Yoon [Korea Institute of Geology Mining and Materials, Taejon (KR)] (and others)

    1999-12-01

    Since 1992 sedimentary basin analysis to assess petroleum potential of the Cretaceous and Tertiary strata in the Korean onshore and continental shelf have been carried out. The Cretaceous non-marine strata mainly occupy the Gyeongsang Basin in southeastern part of the Korean Peninsula and small basins such as Haenam and Gyeokpo depressions in western coastal areas. The Tertiary strata are mostly distributed in Domi, Cheju, Socotra subbasins, and Okinawa Trough in the South Continental Shelf, and Kunsan and Heuksan basins in the West. The basin evolution and petroleum potential for each basins are characterized as follow. The Cretaceous Gyeongsang sediments were deposited in three subbasins including Milyang, Euisung and Yongyang subbasins. The black shales in Nakdong and Jinju formations are interpreted to contain abundant organic matter during the deposition, thermal maturity reaching up to the zone of dry gas formation. Because porosity and permeability are too low, the sandstones can act as a tight gas reservoir rather than conventional oil and gas reservoir. The latest Cretaceous strata of Haenam and Kyeokpo depressions in western coastal area are correlated into the Yuchon Volcanic Group of the Gyeongsang Basin. Petroleum potential of the Early Cretaceous basin in the West Continental Shelf could be relatively high in terms of sedimentary basin filled with thick lacustrine sediments. The Kunsan basin in the West Continental Shelf originated in the Early Cretaceous time expanded during the Paleocene time followed by regional erosion at the end of Paleocene on which Neogene sediment have been accumulated. The Paleocene-Eocene sublacustrine shales may play an major role as a source and cap rocks. South Continental Shelf Basin is subdivided by Cheju subbasin in the center, Socotra Subbasin to the west, Domi Subbasin to the northeast and Okinawa Trough to the East. The potential hydrocarbon traps associated with anticline, titled fault blocks, fault, unconformity

  5. Cenozoic volcanic rocks of Saudi Arabia

    Science.gov (United States)

    Coleman, R.G.; Gregory, R.T.; Brown, G.F.

    2016-01-01

    The Cenozoic volcanic rocks of Saudi Arabia cover about 90,000 km2, one of the largest areas of alkali olivine basalt in the world. These volcanic rocks are in 13 separate fields near the eastern coast of the Red Sea and in the western Arabian Peninsula highlands from Syria southward to the Yemen Arab Republic.

  6. Assignments of methyl rocking modes in trimethylphosphine

    Science.gov (United States)

    McKean, D. C.; McQuillan, G. P.

    Analysis of the vibrational spectra of trimethylphosphine- d3 and d6 leads to identification of the a2 methyl rocking mode at 779 cm -1 in the infrared crystal spectrum of the d0 species. The second e rock is found at 828 cm -1 in the gas phase.

  7. Hot-dry-rock feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    1981-08-01

    The hot-dry-rock project tasks are covered as follows: hot-dry-rock reservoir; generation facilities; water resources; transmission requirements; environmental issues; government and community institutional factors; leasing, ownership and management of facilities; regulations, permits, and laws; and financial considerations. (MHR)

  8. Optically stimulated luminescence dating of rock surfaces

    DEFF Research Database (Denmark)

    Sohbati, Reza

    There are many examples of rock surfaces, rock art and stone structures whose ages are of great importance to the understanding of various phenomena in geology, climatology and archaeology. Optically stimulated luminescence (OSL) dating is a well-established chronological tool that has successful...

  9. Paleozoic sedimentary rocks in oaxaca, Mexico.

    Science.gov (United States)

    Pantoja-Alor, J; Robison, R A

    1967-09-01

    Fossiliferous Cambrian, Ordovician, Mississippian, and Pennsylvanian rocks, never before found in southern Mexico, have been discovered in the Nochixtlán region. Superjacent unfossiliferous sedimentary rocks may be Permian in age. Early Paleozoic and late Paleozoic intervals of marine sedimentation were bounded by intervals of positive tectonism and erosion.

  10. ROCK RIVER CANYON WILDERNESS STUDY AREA, MICHIGAN.

    Science.gov (United States)

    Whitlow, Jesse W.; Morey, Peter C.

    1984-01-01

    A mineral survey of the Rock River Canyon Wilderness study area, Alger County, Michigan, concluded that there is little promise for the occurrence of metallic mineral resources in the study area. High silica sand and crushed rock from quartzose sandstone that is bedrock for much of the area occur but are available in more accessible areas outside of the wilderness.

  11. The History of Rock Art Research

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. The History of Rock Art Research. Rock art in South India was discovered as early as 1891.The earliest discovery of petroglyphs on the Koppagallu hill in Bellary district was made by Fred Fawcett (1892) who with the assistance of H.T.Knox and Robert Sewell ...

  12. Rock Music and Korean Adolescent's Antisocial Behavior.

    Science.gov (United States)

    Kim, Inkyung; Kwak, Keumjoo; Chang, Geunyoung; Yang, Jinyoung

    The relationship between rock music preference and antisocial behavior among Korean adolescents was examined. The Korean versions of the Sensation Seeking Scale and the Antisocial Behavior Checklist were used to measure sensation seeking motivation and delinquency. Adolescents (N=1,079) were categorized as "rock/metal,""dance,"…

  13. RockIT: A Graphical Program for Labeling and Analyzing Rock Scenes

    Science.gov (United States)

    Bornstein, B.; Castano, A.; Anderson, R. C.; Castano, R.

    2005-12-01

    We have developed the Rock Identification Toolkit (RockIT), a mature, cross-platform, graphical program designed to help geologists rapidly and accurately label rocks and particles in images. As images are labeled, RockIT reports both individual rock (or particle) statistics and overall scene statistics. Basic statistics include 2D rock (image) area and average albedo. A more involved set of statistics uses a direct least squares technique to fit a rock trace to an ellipse and report the semimajor and semiminor axes, orientation, eccentricity, and quality of fit. When range data (e.g. derived from a stereo image pair) is available, RockIT provides both 3D rock size and overall scene area estimates. All statistics may be manipulated interactively and later exported to plain, tab-delimited text for easy import into tools like Excel or Matlab for further sophisticated analysis, summarization, and visualization. RockIT can read and display both image and, when available, corresponding range data. Although it supports several popular graphics file formats (e.g. JPEG, TIFF, etc.) our focus has been on more domain-specific file formats, particularly the MER Planetary Data System (PDS) formats. Images, once displayed, may be enhanced in continually, in real-time, throughout the analysis process. Examples of image enhancement include increasing or decreasing brightness and contrast, performing simple min/max intensity normalizations or more complicated histogram equalizations. Several scientists and students at JPL, NASA, Cornell, and PSI use RockIT to identify and characterize rock shape, size, and distribution in MER microscopic imager and panoramic images. Recently, Golombek et al. (2005) used RockIT to compare rock size distributions and calculate cumulative fractional area coverage at several locations along the Spirit traverse. We have a laptop computer running RockIT to demonstrate its capabilities and allow people to experiment on their own.

  14. Regulation of ROCK Activity in Cancer

    DEFF Research Database (Denmark)

    Morgan-Fisher, Marie; Wewer, Ulla M; Yoneda, Atsuko

    2013-01-01

    regulators of the actin cytoskeleton acting downstream of the small GTPase Rho. ROCK is associated with cancer progression, and ROCK protein expression is elevated in several types of cancer. ROCKs exist in a closed, inactive conformation under quiescent conditions, which is changed to an open, active......Cancer-associated changes in cellular behavior, such as modified cell-cell contact, increased migratory potential, and generation of cellular force, all require alteration of the cytoskeleton. Two homologous mammalian serine/threonine kinases, Rho-associated protein kinases (ROCK I and II), are key...... conformation by the direct binding of guanosine triphosphate (GTP)-loaded Rho. In recent years, a number of ROCK isoform-specific binding partners have been found to modulate the kinase activity through direct interactions with the catalytic domain or via altered cellular localization of the kinases. Thus...

  15. Isolated congenital heart block in undifferentiated connective tissue disease and in primary Sjögren’s syndrome: a clinical study of 81 pregnancies in 41 patients

    Directory of Open Access Journals (Sweden)

    S. Todesco

    2011-09-01

    Full Text Available Objective: To study the incidence and the features of congenital heart block (CHB in patients with undifferentiated connective tissue disease (UCTD and primary Sjögren’s syndrome (pSS. Methods: We studied 81 pregnancies of 41 women attending the Outpatients’ Clinic of the Rheumatology Unit of University Hospital of Padova from July 1989 to March 2004. Twenty five of these (61% were affected with UCTD and 16 (39% with pSS. Serologic inclusion criteria was anti-Ro/La positivity, assessed by counterimmunoelectrophoresis and ELISA. Results: CHB was found in 2 out of the 46 (4,3% pregnancies followed by our Staff and in 2 out of the 35 (5,7% included in the retrospective part of the study. In 3 cases CHB was a 3rd degree block, causing pregnancy termination in 2. The only 2nd degree block was identified in one patient at the 22nd week of gestation and treated with dexamethasone and plasma-exchange. All of the women were positive to 52 kd and 60 kd Ro autoantibodies. CHB mothers had higher titer antibodies to 52 kd Ro protein than did the mothers with healthy infants (P = 0,026. Electrocardiographic abnormalities at birth were found in 3 out of 29 asymptomatic infants. One presented sinus bradycardia, the second abnormalities of ventricular repolarization, both regressed spontaneously, while the third ventricular extrasystoles which continue even now at 5 months. Conclusion: These results showed that in UCTD and pSS there is a higher incidence of CHB than that reported in Systemic Lupus Erythematosus. Electrocardiographic screening in all infants born to mothers with anti-Ro/La antibodies would seem an important measure to identify those with irreversible heart conduction abnormalities.

  16. IL10 GGC haplotype is positively and HLA-DQA1*05-DQB1*02 is negatively associated with radiographic progression in undifferentiated arthritis.

    Science.gov (United States)

    Ursum, Jennie; van der Weijden, Mignon A C; van Schaardenburg, Dirkjan; Prins, Arend P A; Dijkmans, Ben A C; Twisk, Jos W R; Crusius, Jakob B A; van der Horst-Bruinsma, Irene E

    2010-07-01

    In rheumatoid arthritis (RA), many genetic markers, such as the shared-epitope (SE) alleles, are described in association with radiographic progression, but limited data are available on undifferentiated arthritis (UA). We investigated whether single-nucleotide polymorphisms (SNP) and haplotypes in immune response genes and HLA class II alleles are associated with radiographic progression in patients with early UA. Progression of radiographic damage was determined in white Dutch patients with early UA after 2 years of followup. Severe progression was defined as an increase in Sharp/van der Heijde Score > or = 5 points after 2 years of followup. The remainder was classified as mild. These SNP were genotyped by Taqman technology: tumor necrosis factor (TNF) -1031, -863, -857, -308, -238; lymphotoxin-alpha (LTA) +368, +252; interleukin 10 (IL10) -2849, -1082, -819; IL1A -889, IL1B -31, +3953; and IL1RN +2018. Carriage of SE alleles and HLA-DQA1*05-DQB1*02 haplotype was established. These markers were analyzed in relation to radiographic progression. Forty-eight out of 151 patients with early UA had severe radiographic progression. Severe radiographic progression was associated with an increased carrier frequency of SE alleles (OR 5.12, 95% CI 2.0-13.1, p HLA-DQA1*05-DQB1*02 haplotype (OR 0.3, 95% CI, 0.1-0.8, p = 0.013) and with allele TNF -308A (OR 0.4, 95% CI, 0.2-0.9, p = 0.02). The SE and the IL10 GGC haplotype are associated with severe progression of radiographic damage, in contrast to the DQA1*05-DQB1*02 haplotype and the TNF -308A allele, which are associated with mild radiographic progression in early UA.

  17. Acetylcholinesterase-positive innervation is present at undifferentiated stages of the sea turtle Lepidochelis olivacea embryo gonads: implications for temperature-dependent sex determination.

    Science.gov (United States)

    Gutiérrez-Ospina, G; Jiménez-Trejo, F J; Favila, R; Moreno-Mendoza, N A; Granados Rojas, L; Barrios, F A; Díaz-Cintra, S; Merchant-Larios, H

    1999-07-19

    In embryos of different reptile species, incubation temperature triggers a cascade of endocrine events that lead to gonad sex differentiation. The cellular and molecular mechanisms by which temperature sets in motion this process are still controversial. Here, we begin evaluating the possible participation of the nervous system in temperature-dependent sex determination by showing the existence and origin of acetylcholinesterase (AchE)-positive nerve fibers in undifferentiated gonads of the Lepidochelys olivacea (L. olivacea) sea turtle putative male and female embryos, along the thermosensitive period for sex determination (TPSD; stages 20-27). AChE-positive nerve bundles and fibers were readily visualized until developmental stage 24 and thereafter. DiI injections and confocal imaging showed that some of these gonadal nerves arise from the lower thoracic and upper lumbar spinal cord levels, and might thus be sensory in nature. Because the vertebrate spinal cord is capable of integrating by itself thermoregulatory responses with no intervention of uppermost levels of the central nervous system, we also evaluated spinal cord maturation during the TPSD. The maturation of the spinal cord was more advanced in putative female than in male embryos, when sex determination is taking place for each sex; this process starts and ends earlier in male than in female embryos. Together these observations open the possibility that the spinal cord and the innervation derived from it could play a direct role in driving or modulating the process of temperature-dependent gonad sex determination and/or differentiation, particularly in female L. olivacea embryos.

  18. Analysis of the immune infiltrate in undifferentiated pleomorphic sarcoma of the extremity and trunk in response to radiotherapy: Rationale for combination neoadjuvant immune checkpoint inhibition and radiotherapy.

    Science.gov (United States)

    Keung, Emily Z; Tsai, Jen-Wei; Ali, Ali M; Cormier, Janice N; Bishop, Andrew J; Guadagnolo, B Ashleigh; Torres, Keila E; Somaiah, Neeta; Hunt, Kelly K; Wargo, Jennifer A; Lazar, Alexander J; Wang, Wei-Lien; Roland, Christina L

    2018-01-01

    Background : Undifferentiated pleomorphic sarcoma of the extremity and trunk (ET-UPS) presents a unique therapeutic challenge. Although immunotherapy has recently been employed in advanced soft tissue sarcoma, there is limited data characterizing the immune infiltrate in ET-UPS. Radiotherapy (RT) has been shown in other tumor types to promote tumor antigen release and enhance tumor-specific targeting by the adaptive immune system. The aim of this study was to 1) characterize the baseline immune infiltrate and 2) evaluate the effect of preoperative RT on the histologic appearance of and the immune infiltrate in ET-UPS. Methods : We identified 17 matched ET-UPS samples before and after RT. Immunohistochemistry was performed with CD8, CD4, PD-L1, PD1, CD3, CD163 and FoxP3 positive cells identified in all samples. Changes in the immune infiltrate following RT were examined. Results : There was a trend towards increased density of tumor infiltrating immune cells in ET-UPS following RT, with increases in median number of CD3 (158 vs 219 cells/mm 2 , p = 0.06), CD4 (3 vs 13 cells/mm 2 , p = 0.01), CD8 (55 vs 111 cells/mm 2 , p = 0.17), and FOXP3 (14 vs 25 cells/mm 2 , p = 0.23) positive cells. Interestingly, although PD-L1 was not expressed in any ET-UPS tumor at baseline, positive PD-L1 expression was observed in 21% (3/14) of tumors after RT (p = 0.07). Conclusion : An immune infiltrate is present in ET-UPS at the time of diagnosis, with a trend towards increased density of immune infiltrate and PD-L1 expression after RT. These data support prospectively evaluating immune checkpoint inhibitors with standard of care RT in the treatment of ET-UPS.

  19. A comparative hospital-based observational study of mono- and co-infections of malaria, dengue virus and scrub typhus causing acute undifferentiated fever.

    Science.gov (United States)

    Ahmad, S; Dhar, M; Mittal, G; Bhat, N K; Shirazi, N; Kalra, V; Sati, H C; Gupta, V

    2016-04-01

    Positive serology for dengue and/or scrub typhus infection with/without positive malarial smear (designated as mixed or co-infection) is being increasingly observed during epidemics of acute undifferentiated febrile illnesses (AUFIs). We planned to study the clinical and biochemical spectrum of co-infections with Plasmodium sp., dengue virus and scrub typhus and compare these with mono-infection by the same organisms. During the period from December 2012 to December 2013, all cases presenting with AUFIs to a single medical unit of a referral centre in Garhwal region of the north Indian state of Uttarakhand were retrospectively selected and categorised aetiologically as co-infections, malaria, dengue or scrub typhus. The groups thus created were compared in terms of demographic, clinical, biochemical and outcome parameters. The co-infection group (n = 49) was associated with milder clinical manifestations, fewer, milder and non-progressive organ dysfunction, and lesser need for intensive care, mechanical ventilation and dialysis as compared to mono-infections. When co-infections were sub-grouped and compared with the relevant mono-infections, there were differences in certain haematological and biochemical parameters; however, this difference did not translate into differential outcomes. Scrub typhus mono-infection was associated with severe disease in terms of both morbidity and mortality. Malaria, dengue and scrub typhus should be routinely tested in all patients with AUFIs. Co-infections, whether true or due to serological cross-reactivity, appear to be a separate entity so far as presentation and morbidity is concerned. Further insight is needed into the mechanism and identification of the protective infection.

  20. Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states

    International Nuclear Information System (INIS)

    Sarver, Aaron L; Cunningham, Julie M; Subramanian, Subbaya; Wang, Liang; Smyrk, Tom C; Rodrigues, Cecilia MP; Thibodeau, Stephen N; Steer, Clifford J; French, Amy J; Borralho, Pedro M; Thayanithy, Venugopal; Oberg, Ann L; Silverstein, Kevin AT; Morlan, Bruce W; Riska, Shaun M; Boardman, Lisa A

    2009-01-01

    Colon cancer arises from the accumulation of multiple genetic and epigenetic alterations to normal colonic tissue. microRNAs (miRNAs) are small, non-coding regulatory RNAs that post-transcriptionally regulate gene expression. Differential miRNA expression in cancer versus normal tissue is a common event and may be pivotal for tumor onset and progression. To identify miRNAs that are differentially expressed in tumors and tumor subtypes, we carried out highly sensitive expression profiling of 735 miRNAs on samples obtained from a statistically powerful set of tumors (n = 80) and normal colon tissue (n = 28) and validated a subset of this data by qRT-PCR. Tumor specimens showed highly significant and large fold change differential expression of the levels of 39 miRNAs including miR-135b, miR-96, miR-182, miR-183, miR-1, and miR-133a, relative to normal colon tissue. Significant differences were also seen in 6 miRNAs including miR-31 and miR-592, in the direct comparison of tumors that were deficient or proficient for mismatch repair. Examination of the genomic regions containing differentially expressed miRNAs revealed that they were also differentially methylated in colon cancer at a far greater rate than would be expected by chance. A network of interactions between these miRNAs and genes associated with colon cancer provided evidence for the role of these miRNAs as oncogenes by attenuation of tumor suppressor genes. Colon tumors show differential expression of miRNAs depending on mismatch repair status. miRNA expression in colon tumors has an epigenetic component and altered expression that may reflect a reversion to regulatory programs characteristic of undifferentiated proliferative developmental states

  1. [Evidence-based recommendations for the management of undifferentiated peripheral inflammatory arthritis (UPIA). The German perspective on the international 3e initiative].

    Science.gov (United States)

    Tarner, I H; Albrecht, K; Fleck, M; Gromnica-Ihle, E; Keyßer, G; Köhler, L; Kötter, I; Krüger, K; Kuipers, J; Nüßlein, H; Rubbert-Roth, A; Wollenhaupt, J; Schneider, M; Manger, B; Müller-Ladner, U

    2014-05-01

    Peripheral arthritis is the most common presenting complaint in clinical rheumatology. Unequivocal identification of the underlying entity can be difficult, particularly at an early stage. Such cases are commonly referred to as undifferentiated peripheral inflammatory arthritis (UPIA). Since evidence-based recommendations for the clinical management of UPIA are lacking, this international 3e initiative convened 697 rheumatologists from 17 countries to develop appropriate recommendations. Based on a systematic literature research in Medline, EMBASE, Cochrane Library, and the ACR/EULAR abstracts of 2007/2008, 10 multinational recommendations were developed by 3 rounds of a Delphi process. In Germany, a national group of experts worked on 3 additional recommendations using the same method. The recommendations were discussed among the members of the 3e initiative and the degree of consensus was analyzed as well as the potential impact of the recommendations on clinical practice. A total of 39,756 references were identified, of which 250 were systematically reviewed for the development of 10 multinational recommendations concerning differential diagnosis, diagnostic and prognostic value of clinical assessments, laboratory tests and imaging techniques, and monitoring of UPIA. In addition, 3 national recommendations on the diagnostic and prognostic value of a response to anti-inflammatory therapy on the analysis of synovial fluid and on enthesitis were developed by the German experts based on 35 out of 5542 references. The article translates the 2011 published original paper of the international 3e initiative (Machado et al., Ann Rheum Dis 70:15-24, 2011) and reports the methods and results of the national vote and the additional 3 national recommendations.

  2. Fragment Size Distribution of Blasted Rock Mass

    Science.gov (United States)

    Jug, Jasmin; Strelec, Stjepan; Gazdek, Mario; Kavur, Boris

    2017-12-01

    Rock mass is a heterogeneous material, and the heterogeneity of rock causes sizes distribution of fragmented rocks in blasting. Prediction of blasted rock mass fragmentation has a significant role in the overall economics of opencast mines. Blasting as primary fragmentation can significantly decrease the cost of loading, transport, crushing and milling operations. Blast fragmentation chiefly depends on the specific blast design (geometry of blast holes drilling, the quantity and class of explosive, the blasting form, the timing and partition, etc.) and on the properties of the rock mass (including the uniaxial compressive strength, the rock mass elastic Young modulus, the rock discontinuity characteristics and the rock density). Prediction and processing of blasting results researchers can accomplish by a variety of existing software’s and models, one of them is the Kuz-Ram model, which is possibly the most widely used approach to estimating fragmentation from blasting. This paper shows the estimation of fragmentation using the "SB" program, which was created by the authors. Mentioned program includes the Kuz-Ram model. Models of fragmentation are confirmed and calibrated by comparing the estimated fragmentation with actual post-blast fragmentation from image processing techniques. In this study, the Kuz-Ram fragmentation model has been used for an open-pit limestone quarry in Dalmatia, southern Croatia. The resulting calibrated value of the rock factor enables the quality prognosis of fragmentation in further blasting works, with changed drilling geometry and blast design parameters. It also facilitates simulation in the program to optimize blasting works and get the desired fragmentations of the blasted rock mass.

  3. Stratigraphy and structure of volcanic rocks in drill hole USW-G1, Yucca Mountain, Nye County, Nevada

    International Nuclear Information System (INIS)

    Spengler, R.W.; Byers, F.M. Jr.; Warner, J.B.

    1981-01-01

    Detailed subsurface studies in connection with the Nevada Nuclear Waste Storage Investigations program are being conducted to investigate the stratigraphic and structural features of volcanic rocks underlying Yucca Mountain, a volcanic highland situated along the western boundary of the Nevada Test Site in southern Nevada. As part of this continuing effort, drill hole USW-G1 was cored from 292 ft to a depth of 6000 ft from March to August 1980. The stratigraphic section is composed of thick sequences of ash-flow tuff and volcanic breccia interbedded with subordinate amounts of fine- to coarse-grained volcaniclastic rocks. All rocks are of Tertiary age and vary in composition from rhyolite to dacite. The 3005-ft level in the drill hole represents a significant demarcation between unaltered and altered volcanic rocks. For the most part, tuff units above 3005 ft appear devitrified and show little secondary alteration except within tuffaceous beds of Calico Hills, where the rock contains 60 to 80% zeolites. Below 3005 ft, most rocks show intermittent to pervasive alteration to clay minerals and zeolites. Examination of core for structural features revealed the presence of 61 shear fractures, 528 joints, and 4 conspicuous fault zones. Shear fractures mainly occurred in the Topopah Spring Member of the Paintbrush Tuff, flow breccia, and near fault zones. Nearly 88% of shear and joint surfaces show evidence of coatings. Approximately 40% of the fractures were categorized as completely healed. Rock quality characteristics as defined by the core index indicate that greater amounts of broken and lost core are commonly associated with (1) the densely welded zone of the Topopah Spring, (2) highly silicified zones, and (3) fault zones

  4. Detailed petrographic descriptions and microprobe data for tertiary silicic volcanic rocks in drill hole USW G-1, Yucca Mountain, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Caporuscio, F.A.; Warren, R.G.; Broxton, D.E.

    1985-12-01

    This report contains detailed petrographic descriptions of 74 thin sections from drill hole USW G-1 at Yucca Mountain, Nevada. These descriptions are keyed to the distinctions between devitrified, vitrophyre, vitric, and zeolitized intervals below the Topopah Spring Member repository horizon. The petrographic features of the zeolitized intervals down through the Crater Flat tuff, as well as the sorption properties determined from these intervals, suggest that these zeolite occurrences may each have comparable sorptive capability.

  5. Organic geochemical characterization of potential hydrocarbon source rocks in the upper Benue Trough

    International Nuclear Information System (INIS)

    Obaje, N. G.; Pearson, M. J.; Suh, C. E.; Dada, S. S.

    1999-01-01

    The Upper Benue Trough of Nigeria is the northeastern most portion of the Benue rift structure that extends from the northern limit of the Niger Delta in the south to the southern limit of the Chad basin int he northeast. this portion of the trough is made up of two arms: the Gongola Arm and the Yola Arm. Stratigraphic sequence in the Gongola Arm comprises the continental Albian Bima Sandstone, the transitional Cenomanian Yolde Formation and the marine Turonian - Santonian Gongila, Pindiga, and Fika Formations. Overlying these are the continental Campane - Maastrichtian Gombe Sandstone and the Tertiary Kerri - Kerri Formation. In the Yola Arm, the Turonian - Santonian sequence is replaced by the equally marine Dukul, Jessu, Sekuliye Formations, Numanha Shale, and the Lamja Sandstone. Organic geochemical studies have been carried on outcrop sample form the Gongila, Pindiga, Dukul Formations, the Fika shale and the shaly units of the Gombe Sandstone, with the aim of assessing their source rock potential. Gas Chromatography (GC), Gas Chromatography - Mass Spectrometry (C - MS), and Rock Eval Pyrolysis were the major organic geochemical tools employed. Biomaker hydrocarbon signatures obtained from the GC - MS and the Rock Eval Pyrolysis results indicate that all he formations studied, except the Dukul formation, are immature and are all lean in organic matter

  6. Sexual harassment experiences of female graduates of Nigerian tertiary institutions.

    Science.gov (United States)

    Owoaje, Eme T; Olusola-Taiwo, Omolara

    The sexual harassment experiences of female graduates from tertiary institutions in Nigeria, were explored using self-administered questionnaires. Information was obtained on the respondents' socio-demographic characteristics and experiences of sexual harassment while in their various tertiary institutions. The majority (69.8%) of the respondents had been sexually harassed, with the main perpetrators being male classmates and lecturers. About two-thirds experienced the non-physical type of sexual harassment; 48.2% experienced the physical type. Non-physical harassment included sexual comments (57.8%) and requests to do something sexual in exchange for academic favors (32.2%). Physical forms of sexual harassment included unwanted sexual touching (29.4%) and being intentionally brushed against in a sexual way (28.9%). The effects experienced by victims were depression and perceived insecurity on campus. Sexual harassment is a common occurrence in Nigerian tertiary institutions. Appropriate institutional interventions should be developed to reduce these occurrences.

  7. Mechanisms for tertiary creep of single crystal superalloy

    Science.gov (United States)

    Staroselsky, Alexander; Cassenti, Brice

    2008-12-01

    During the thermal-mechanical loading of high temperature single crystal turbine components, all three creep—stages: primary, secondary and tertiary, manifest themselves and, hence, none of them can be neglected. The development of a creep law that includes all three stages is especially important in the case of non-homogeneous thermal loading of the component where significant stress redistribution and relaxation will result. Thus, local creep analysis is crucial for proper design of damage tolerant airfoils. We have developed a crystallographic-based constitutive model and fully coupled it with damage kinetics. The model extends existing approaches for cyclic and thermal-cyclic loading of anisotropic elasto-viscoplastic deformation behavior and damage kinetics of single-crystal materials, allowing prediction of tertiary creep and failure initiation of high temperature components. Our damage model bridges the gap between dislocation dynamics and the continuum mechanics scales and can be used to represent tertiary as well as primary and secondary creep.

  8. Rock stars for the day

    CERN Multimedia

    Stefania Pandolfi

    2015-01-01

    After a two-year hiatus, the CERN Hardronic Festival is back! On 8 August, ten CERN MusiClub bands will take to the stage for the popular event. As usual, the non-stop show will take place on the terrace of Restaurant 3 and will run until after midnight.   The Canettes Blues Band, part of the CERN MusiClub, performing live on the Music In The Park stage at the Montreux Jazz Festival, on 18 July 2013. A large range of musical styles will entertain the audience: from Irish folk, via 70s/80s/90s rock, to pop, blues and R&B. Alongside the music there will be activities for kids and food and drink stands. This year, the income from food sales will be donated to charity. The spirit that has characterised the festival ever since the first event in 1989 is that of a staff party. Any band who volunteers to play also helps to organise the event and set up the stage. “This is a really good thing because a festival that has been growing for many years requires a considerable amount of har...

  9. Tracer transport in fractured rocks

    International Nuclear Information System (INIS)

    Tsang, C.F.; Tsang, Y.W.; Hale, F.V.

    1988-07-01

    Recent interest in the safety of toxic waste underground disposal and nuclear waste geologic repositories has motivated many studies of tracer transport in fractured media. Fractures occur in most geologic formations and introduce a high degree of heterogeneity. Within each fracture, the aperture is not constant in value but strongly varying. Thus for such media, tracer tends to flow through preferred flowpaths or channels within the fractures. Along each of these channels, the aperture is also strongly varying. A detailed analysis is carried out on a 2D single fracture with variable apertures and the flow through channels is demonstrated. The channels defined this way are not rigidly set pathways for tracer transport, but are the preferred flow paths in the sense of stream-tubes in the potential theory. It is shown that such variable-aperture channels can be characterized by an aperture probability distribution function, and not by the exact deterministic geometric locations. We also demonstrate that the 2D tracer transport in a fracture can be calculated by a model of a system of 1D channels characterized by this distribution function only. Due to the channeling character of tracer transport in fractured rock, random point measurements of tracer breakthrough curves may give results with a wide spread in value due to statistical fluctuations. The present paper suggests that such a wide spread can probably be greatly reduced by making line/areal (or multiple) measurements covering a few spatial correlation lengths. 13 refs., 11 figs., 1 tab

  10. Terrestrial impact melt rocks and glasses

    Science.gov (United States)

    Dressler, B. O.; Reimold, W. U.

    2001-12-01

    The effects of meteorite and comet impact on Earth are rock brecciation, the formation of shock metamorphic features, rock melting, and the formation of impact structures, i.e. simple craters, complex craters, and multi-ring basins. Large events, such as the 65-Ma Chicxulub impact, are believed to have had catastrophic environmental effects that profoundly influenced the development of life on Earth. In this review, an attempt is made to summarize some of the voluminous literature on impact melting, one important aspect of planetary impact, provide some comments on this process, and to make suggestions for future research. The products of impact melting are glasses, impact melt rocks, and pseudotachylites. Our treatise deals mainly with the geological setting, petrography, and major-element chemistry of melt rocks and glasses. Impact glasses, in several petrographic aspects, are similar to volcanic glasses, but they are associated with shock metamorphosed mineral and rock fragments and, in places, with siderophile element anomalies suggestive of meteoritic contamination. They are found in allogenic breccia deposits within (fall-back 'suevite') and outside (fall-out 'suevite') impact craters and, as spherules, in distal ejecta. Large events, such as the K/T boundary Chicxulub impact, are responsible for the formation of worldwide ejecta horizons which are associated with siderophile element anomalies and shock metamorphosed mineral and rock debris. Impact glasses have a bulk chemical composition that is homogeneous but exemptions to this rule are common. On a microscopic scale, however, impact glasses are commonly strikingly heterogeneous. Tektites are glasses ejected from craters over large distances. They are characterized by very low water and volatile contents and element abundances and ratios that are evidence that tektites formed by melting of upper crustal, sedimentary rocks. Four tektite strewn-fields are known, three of which can be tied to specific impact

  11. Rock cavern storage of spent fuel

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Won Jin; Kim, Kyung Soo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kwon, Sang Ki [Inha University, Incheon (Korea, Republic of)

    2015-12-15

    The rock cavern storage for spent fuel has been assessed to apply in Korea with reviewing the state of the art of the technologies for surface storage and rock cavern storage of spent fuel. The technical feasibility and economic aspects of the rock cavern storage of spent fuel were also analyzed. A considerable area of flat land isolated from the exterior are needed to meet the requirement for the site of the surface storage facilities. It may, however, not be easy to secure such areas in the mountainous region of Korea. Instead, the spent fuel storage facilities constructed in the rock cavern moderate their demands for the suitable site. As a result, the rock cavern storage is a promising alternative for the storage of spent fuel in the aspect of natural and social environments. The rock cavern storage of spent fuel has several advantages compared with the surface storage, and there is no significant difference on the viewpoint of economy between the two alternatives. In addition, no great technical difficulties are present to apply the rock cavern storage technologies to the storage of domestic spent fuel.

  12. Sedimentation and transportation of mud rock material

    Science.gov (United States)

    Lin, J.; Ochiai, S.

    2008-12-01

    This research focuses on the transportation and sedimentation of mud rock slope at Niupu, southern Taiwan. The main purpose of this research is trying to identify the mechanism of erosion and sedimentation rate of the mud rock from the slope into the lake. By using regular sonar surveying and rainfall data, it is possible to identify a high erosion rate on mud rock area. The cementation of Miocene mud rock is loose and slope at 40-45 degree which is highly sensitive to the rainfall. It is also vulnerable to the erosion processes. There are some interesting characters related to the observation and surveying. The erosion processes are highly related to amounts of rainfall. When there is typhoon, tropical storm, there is high erosion. The erosion could occur when there is rainfall more than 10 mm/event and the surface of the mud rock could be incised up to 3 cm after 30 mm rainfall. The sedimentation rate could also as high as 0.5 m when there are two typhoons which attacked to this area within three months. This research also demonstrates that the high erosion on mud rock area will generate high sedimentation and high denudation rate. However the comparison of the rate of erosion and deposition is identified in this presentation. For hazard mitigation purpose, it is necessary to reduce the bared mud rock slope area to prevent the further erosion.

  13. Discussion on the origin of sedimentary rock resistivity

    International Nuclear Information System (INIS)

    Dong Gangjian

    2012-01-01

    Conduction current way of sedimentary rock sedimentary rock is caused by the internal structure of sedimentary rock sedimentary rock pore resistance depends on the salinity of pore water and clay content and distribution. Resistivity of sedimentary rock sedimentary rock major factor in mineral composition, water resistance, oil resistance. and sedimentary structures. In practice, we should give full attention to the difference between lithology and physical properties. (author)

  14. Spatio-temporal observations of the tertiary ozone maximum

    Directory of Open Access Journals (Sweden)

    V. F. Sofieva

    2009-07-01

    Full Text Available We present spatio-temporal distributions of the tertiary ozone maximum (TOM, based on GOMOS (Global Ozone Monitoring by Occultation of Stars ozone measurements in 2002–2006. The tertiary ozone maximum is typically observed in the high-latitude winter mesosphere at an altitude of ~72 km. Although the explanation for this phenomenon has been found recently – low concentrations of odd-hydrogen cause the subsequent decrease in odd-oxygen losses – models have had significant deviations from existing observations until recently. Good coverage of polar night regions by GOMOS data has allowed for the first time to obtain spatial and temporal observational distributions of night-time ozone mixing ratio in the mesosphere.

    The distributions obtained from GOMOS data have specific features, which are variable from year to year. In particular, due to a long lifetime of ozone in polar night conditions, the downward transport of polar air by the meridional circulation is clearly observed in the tertiary ozone maximum time series. Although the maximum tertiary ozone mixing ratio is achieved close to the polar night terminator (as predicted by the theory, TOM can be observed also at very high latitudes, not only in the beginning and at the end, but also in the middle of winter. We have compared the observational spatio-temporal distributions of the tertiary ozone maximum with that obtained using WACCM (Whole Atmosphere Community Climate Model and found that the specific features are reproduced satisfactorily by the model.

    Since ozone in the mesosphere is very sensitive to HOx concentrations, energetic particle precipitation can significantly modify the shape of the ozone profiles. In particular, GOMOS observations have shown that the tertiary ozone maximum was temporarily destroyed during the January 2005 and December 2006 solar proton events as a result of the HOx enhancement from the increased ionization.

  15. Uranium deposits in magmatic and metamorphic rocks

    International Nuclear Information System (INIS)

    1989-01-01

    The association of uranium with certain types of magmatic and metamorphic rocks is well known. They have consequently been explored and studied quite extensively. In recent years interest in them has been eclipsed by the discovery of larger, lower cost deposits in other geological environments. Nonetheless, magmatic and metamorphic rocks continue to be important sources of uranium and large areas of the Earth's crust with such rocks are prospective locations for additional discoveries. As future exploration and development could be more difficult the full importance of individual deposits may not be recognized until after many years of investigation and experience. In addition to being important host rocks, magmatic and metamorphic rocks have been of considerable interest to uranium geologists as they are considered to be important source rocks for uranium and thus can lead to deposits nearby in other environments. Furthermore, these rocks provide important information on the geochemical cycle of uranium in the Earth's crust and mantle. Such information can lead to identification of uranium provinces and districts and to a basic understanding of processes of formation of uranium deposits. The International Atomic Energy Agency convened a Technical Committee Meeting on Uranium Deposits in Magmatic and Metamorphic Rocks. The meeting was held in Salamanca, Spain, from 29 September to 3 October 1986. It was followed by a two day field trip to uranium deposits in the Ciudad Rodrigo and Don Benito areas. The meeting was attended by 48 participants from 22 countries. Two panels were organized for discussion of the following topics: (1) ore deposit genesis and characterization and (2) exploration and resource assessment. The technical papers together with the panel reports form this publication. The scope and variety of the papers included and the panel reports provide a good coverage of current knowledge and thinking on uranium in magmatic and metamorphic rocks

  16. Sinkhole susceptibility in carbonate rocks of the Apulian karst (southern Italy)

    Science.gov (United States)

    Di Santo, Antonio; Fazio, Nunzio L.; Fiore, Antonio; Lollino, Piernicola; Luisi, Michele; Miccoli, Maria N.; Pagliarulo, Rosa; Parise, Mario; Perrotti, Michele; Pisano, Luca; Spalluto, Luigi; Vennari, Carmela; Vessia, Giovanna

    2016-04-01

    Apulia region, the foreland of the southern Italian Apennines, is made up of a 6-7 km-thick succession of Mesozoic shallow-water limestones and dolostones, locally covered by thin and discontinuous Tertiary and Quaternary carbonate and clastic deposits. Due to their long subaerial exposure, the Mesozoic carbonate bedrock recorded the development in the subsurface of a dense network of karst cavities, mostly controlled by tectonic discontinuities. As a result, a strong susceptibility to natural sinkholes has to be recorded in Apulia. In addition, the possibility of occurrence of other problems related to the high number of man-made cavities has to be added in the region. A great variety of different typologies of artificial cavities (mostly excavated in the Plio-Pleistocene soft calcarenites) is actually present, including underground quarries, worship sites, oil mills, civilian settlements, etc. Overall, 2200 natural and 1200 artificial cavities, respectively, have been so far surveyed in Apulia. Following the urban development in the last century in Apulia, many of these cavities lie nowadays below densely populated neighborhoods, roads or communication routes. These conditions are at the origin of the main geomorphological hazard for the human society in Apulia, which requires a careful evaluation, aimed at protecting and safeguarding the human life, and at providing the necessary information for a correct land use planning and management. The importance of the sinkhole hazard is further testified by the worrying increase in the number of events during the last 5-6 years. In response to these situations, joint research activities were started by the Institute of Research for Hydrological Protection of the National Research Council (CNR-IRPI) and the Basin Authority of Apulia, aimed at several goals, that include (but are not limited to) the collection of information on natural and anthropogenic sinkholes in Apulia, the implementation of numerical analyses for

  17. Sexual harassment in tertiary institutions: A comparative perspective

    Directory of Open Access Journals (Sweden)

    Joseph Janice

    2015-01-01

    Full Text Available Sexual harassment is not a new phenomenon in tertiary institutions. It has been receiving considerable attention in research and the media and public awareness has increased dramatically. However, the term sexual harassment is not used uniformly across the globe because countries have defined it differently. Consequently, prevalence of sexual harassment in education varies across cultures. This paper examines sexual harassment from a comparative perspective. It specifically focuses on the definition of sexual harassment, incidence of sexual harassment of students in tertiary institutions, effects of sexual harassment on victims; and victims’ responses to sexual harassment. It also offers suggestions for curtailing sexual harassment in these institutions.

  18. Discovery of Tertiary Sulfonamides as Potent Liver X Receptor Antagonists

    Energy Technology Data Exchange (ETDEWEB)

    Zuercher, William J.; Buckholz†, Richard G.; Campobasso, Nino; Collins, Jon L.; Galardi, Cristin M.; Gampe, Robert T.; Hyatt, Stephen M.; Merrihew, Susan L.; Moore, John T.; Oplinger, Jeffrey A.; Reid, Paul R.; Spearing, Paul K.; Stanley, Thomas B.; Stewart, Eugene L.; Willson, Timothy M. (GSKNC)

    2010-08-12

    Tertiary sulfonamides were identified in a HTS as dual liver X receptor (LXR, NR1H2, and NR1H3) ligands, and the binding affinity of the series was increased through iterative analogue synthesis. A ligand-bound cocrystal structure was determined which elucidated key interactions for high binding affinity. Further characterization of the tertiary sulfonamide series led to the identification of high affinity LXR antagonists. GSK2033 (17) is the first potent cell-active LXR antagonist described to date. 17 may be a useful chemical probe to explore the cell biology of this orphan nuclear receptor.

  19. Usability of cerebrospinal fluid biomarkers in a tertiary memory clinic

    DEFF Research Database (Denmark)

    Brandt, C.; Bahl, J.C.; Heegaard, N.H.

    2008-01-01

    AIM: Assays for cerebrospinal fluid (CSF) levels of total tau, phospho-tau protein and beta-amyloid 1-42 have been available for some years. The aim of the study was to assess the usability of these biomarkers in a mixed population of tertiary dementia referral patients in a university-based memory......, the sensitivity of a single abnormal value was between 33 and 66%. The specificity was high except when discriminating AD from amnestic mild cognitive impairment. Two or more abnormal markers further increased the specificity and decreased the sensitivity. CONCLUSION: In a tertiary setting, abnormal CSF biomarker...

  20. Radon and rock bursts in deep mines

    International Nuclear Information System (INIS)

    Bulashevich, Yu.P.; Utkin, V.I.; Yurkov, A.K.; Nikolaev, V.V.

    1996-01-01

    Variation fields of radon concentration in time to ascertain stress-strain state of the North Ural bauxite mines have been studied. It is shown that dynamic changes in the stress-strain state of the rocks prior to the rock burst bring about variations in radon concentration in the observation wells. Depending on mutual positioning of the observation points and the rock burst epicenter, the above-mentioned variations differ in principle, reduction of radon concentration in the near zone and its increase in the far zone are observed [ru

  1. Laboratory measurements of rock thermal properties

    DEFF Research Database (Denmark)

    Bording, Thue Sylvester; Balling, N.; Nielsen, S.B.

    The thermal properties of rocks are key elements in understanding and modelling the temperature field of the subsurface. Thermal conductivity and thermal diffusivity can be measured in the laboratory if rock samples can be provided. We have introduced improvements to the divided bar and needle...... probe methods to be able to measure both thermal conductivity and thermal diffusivity. The improvements we implement include, for both methods, a combination of fast numerical finite element forward modelling and a Markov Chain Monte Carlo inversion scheme for estimating rock thermal parameters...

  2. Lead isotopes in archaean plutonic rocks

    International Nuclear Information System (INIS)

    Oversby, V.M.

    1978-01-01

    Archaean intrusive rocks have initial Pb isotopic compositions which show a varied and complex history for the source regions of the rocks. Even the oldest rocks from Greenland indicate heterogenous U and Pb distribution prior to 3800 m.y. ago. Source regions with μ values less than 7 must have played a significant role in the early history of the earth. By late Archaean time U/Pb ratios of source regions had increased substantially. Data from Australia and North America show distinct regional differences, both within and between continents. (Auth.)

  3. Sliding rocks on Racetrack Playa, Death Valley National Park: first observation of rocks in motion.

    Science.gov (United States)

    Norris, Richard D; Norris, James M; Lorenz, Ralph D; Ray, Jib; Jackson, Brian

    2014-01-01

    The engraved trails of rocks on the nearly flat, dry mud surface of Racetrack Playa, Death Valley National Park, have excited speculation about the movement mechanism since the 1940s. Rock movement has been variously attributed to high winds, liquid water, ice, or ice flotation, but has not been previously observed in action. We recorded the first direct scientific observation of rock movements using GPS-instrumented rocks and photography, in conjunction with a weather station and time-lapse cameras. The largest observed rock movement involved > 60 rocks on December 20, 2013 and some instrumented rocks moved up to 224 m between December 2013 and January 2014 in multiple move events. In contrast with previous hypotheses of powerful winds or thick ice floating rocks off the playa surface, the process of rock movement that we have observed occurs when the thin, 3 to 6 mm, "windowpane" ice sheet covering the playa pool begins to melt in late morning sun and breaks up under light winds of -4-5 m/s. Floating ice panels 10 s of meters in size push multiple rocks at low speeds of 2-5 m/min. along trajectories determined by the direction and velocity of the wind as well as that of the water flowing under the ice.

  4. Rapid formation of rock armour for soil - rock fragment mixture during simulated rainfall

    Science.gov (United States)

    Poultney, E.; McGrath, G. S.; Hinz, C.

    2009-04-01

    Preventing erosion is an important issue in disturbed semi-arid and arid landscapes. This is in particular of highest importance for mining companies while undertaking land rehabilitation. An onsite investigation of the impact of surface rock fragments on erosion was conducted at Telfer goldmine in the Great Sandy Desert, Western Australia. The study site is a waste rock dump designed to mimic the concave slope of a natural mesa to both discourage erosion and blend in with its natural surroundings. Four treatments were used to construct the slope: two are topsoil mixed with rock fragments, and two are unmixed topsoil. A field study investigating erosion rills, particle size distribution, rock fragment coverage surface roughness and vegetation was carried out to determine changes down and across slope. The treatments constructed by mixing topsoil and rock fragments are more stable and show rock fragment distributions that more closely resemble patterns found on natural mesas surrounding Telfer. A controlled study using trays of topsoil mixed with rock fragment volumes of 50%, 60%, 70% and 80% were used to investigate how varying mixtures of rock fragments and topsoil erode using rainfall intensities between 20 and 100 mm h-1. Two runs of 25 minutes each were used to assess the temporal evolution of rock armouring. Surface coverage results converged for the 50%, 60% and 70% mixtures after the first run to coverage of about 90%, suggesting that fine sediment proportion does not affect rate and degree of rock armouring.

  5. Sliding rocks on Racetrack Playa, Death Valley National Park: first observation of rocks in motion.

    Directory of Open Access Journals (Sweden)

    Richard D Norris

    Full Text Available The engraved trails of rocks on the nearly flat, dry mud surface of Racetrack Playa, Death Valley National Park, have excited speculation about the movement mechanism since the 1940s. Rock movement has been variously attributed to high winds, liquid water, ice, or ice flotation, but has not been previously observed in action. We recorded the first direct scientific observation of rock movements using GPS-instrumented rocks and photography, in conjunction with a weather station and time-lapse cameras. The largest observed rock movement involved > 60 rocks on December 20, 2013 and some instrumented rocks moved up to 224 m between December 2013 and January 2014 in multiple move events. In contrast with previous hypotheses of powerful winds or thick ice floating rocks off the playa surface, the process of rock movement that we have observed occurs when the thin, 3 to 6 mm, "windowpane" ice sheet covering the playa pool begins to melt in late morning sun and breaks up under light winds of -4-5 m/s. Floating ice panels 10 s of meters in size push multiple rocks at low speeds of 2-5 m/min. along trajectories determined by the direction and velocity of the wind as well as that of the water flowing under the ice.

  6. Magnetic Anisotropy as an aid to Identifying CRM and DRM in Red Sedimentary Rocks

    Science.gov (United States)

    Kodama, K. P.; Dekkers, M. J.

    2004-12-01

    To evaluate the usefulness of magnetic anisotropy for determining the origin of the natural remanent magnetization (NRM) in red sedimentary rocks, several new remanence anisotropy measurement techniques were investigated. The goal of the work was an accurate separation of the remanence anisotropy of magnetite and hematite in the same sedimentary rock sample. In one technique, Tertiary red and grey sedimentary rock samples from the Orera section of Spain were exposed to 13 T fields in 9 different orientations. This work was done at the High Field Magnet Laboratory of Radboud University, Nijmegen, The Netherlands. In each orientation, alternating field (af) demagnetization was used to separate the magnetite and hematite contributions to the high field isothermal remanent magnetization (IRM). Tensor subtraction was used to separate the magnetite and hematite magnetic anisotropies. Geologically interpretable fabrics did not result, probably because of the presence of goethite. In the second technique, also applied to samples from Orera, an anisotropy of anhysteretic remanence (AAR) was applied in af fields up to 240 mT to directly measure the fabric of the magnetite in the sample. IRMs applied in 2T fields followed by 240 mT af demagnetization, and thermal demagnetization at 90° C to remove the goethite contribution, were used to independently measure the hematite fabric in the same samples. This approach gave magnetic fabrics with minimum principal axes perpendicular to bedding, suggesting that the hematite and magnetite grains in the Orera samples both carry a depositional remanent magnetization (DRM). In a third experiment, IRMs applied in 13 T fields were used to measure the magnetic fabric of samples from the Dome de Barrot area in France. These samples had been demonstrated to have hematite as their only magnetic mineral. The fabrics that resulted were geologically interpretable, showing a strong NW-SE horizontal lineation consistent with AMS fabrics measured in

  7. RESULTS OF A DATING ATTEMPT -CHEMICAL AND PHYSICAL MEASUREMENTS RELEVANT TO THE CASE OF THE CRETACEOUS TERTIARY EXTINCTIONS

    Energy Technology Data Exchange (ETDEWEB)

    Asaro, Frank; Michel, Helen V.; Alvarez, Luis W.; Alvarez, Walter

    1980-09-01

    In Gubbio, Italy, a l em layer of clay between extensive limestone formations marks the boundary between the Cretaceous and Tertiary Periods. This clay layer was known to have been deposited about 65 million years ago when many life forms became extinct, but the length of time associated with the deposition was not known. In an attempt to measure this time with normally deposited meteoritic material as a clock, extensive measurements of iridium abundances (and those of many other elements) were made on the Gubbio rocks. Neutron activation analysis was the principal tool used in these studies. About 50 elements are searched for in materials like the earth's crust, about 40 are detected and about 30 are measured with useful precision. We were not able to determine exactly how long the clay deposition took. Instead the laboratory studies on the chemical and physical nature of the Cretaceous-Tertiary boundary led to the theory that an asteroid collision with the earth was responsible for the extinction of many forms of life including the dinosaurs.

  8. Biogenic Cracks in Porous Rock

    Science.gov (United States)

    Hemmerle, A.; Hartung, J.; Hallatschek, O.; Goehring, L.; Herminghaus, S.

    2014-12-01

    Microorganisms growing on and inside porous rock may fracture it by various processes. Some of the mechanisms of biofouling and bioweathering are today identified and partially understood but most emphasis is on chemical weathering, while mechanical contributions have been neglected. However, as demonstrated by the perseverance of a seed germinating and cracking up a concrete block, the turgor pressure of living organisms can be very significant. Here, we present results of a systematic study of the effects of the mechanical forces of growing microbial populations on the weathering of porous media. We designed a model porous medium made of glass beads held together by polydimethylsiloxane (PDMS), a curable polymer. The rheological properties of the porous medium, whose shape and size are tunable, can be controlled by the ratio of crosslinker to base used in the PDMS (see Fig. 1). Glass and PDMS being inert to most chemicals, we are able to focus on the mechanical processes of biodeterioration, excluding any chemical weathering. Inspired by recent measurements of the high pressure (~0.5 Mpa) exerted by a growing population of yeasts trapped in a microfluidic device, we show that yeast cells can be cultured homogeneously within porous medium until saturation of the porous space. We investigate then the effects of such an inner pressure on the mechanical properties of the sample. Using the same model system, we study also the complex interplay between biofilms and porous media. We focus in particular on the effects of pore size on the penetration of the biofilm within the porous sample, and on the resulting deformations of the matrix, opening new perspectives into the understanding of life in complex geometry. Figure 1. Left : cell culture growing in a model porous medium. The white spheres represent the grains, bonds are displayed in grey, and microbes in green. Right: microscopy picture of glass beads linked by PDMS bridges, scale bar: 100 μm.

  9. Evaluation of prognostic factors in localized high-grade undifferentiated pleomorphic sarcoma: report of a multi-institutional experience of Anatolian Society of Medical Oncology.

    Science.gov (United States)

    Ozcelik, Melike; Seker, Mesut; Eraslan, Emrah; Koca, Sinan; Yazilitas, Dogan; Ercelep, Ozlem; Ozaslan, Ersin; Kaya, Serap; Hacibekiroglu, Ilhan; Menekse, Serkan; Aksoy, Asude; Taskoylu, Burcu Yapar; Varol, Umut; Arpaci, Erkan; Ciltas, Aydin; Oksuzoglu, Berna; Zengin, Nurullah; Gumus, Mahmut; Aliustaoglu, Mehmet

    2016-04-01

    Most data on prognostic factors for patients with high-grade undifferentiated pleomorphic sarcoma (HGUPS) is obtained from analyses of soft tissue sarcomas. The purpose of this study was to evaluate the clinicopathologic features and their impact on outcomes specifically in patients diagnosed with HGUPS. In this multicenter trial, we retrospectively analyzed 112 patients who were diagnosed and treated at 12 different institutions in Turkey. We collected data concerning the patients, tumor characteristics, and treatment modalities. There were 69 males (61.6 %) and 43 females (38.4 %). Median age was 56 years (19-90). The most common anatomic site of tumor origin was the upper extremity. Pleomorphic variant was the predominant histological subtype. Median tumor size was 8.2 cm (0.6-30 cm). Tumors were mainly deeply seated (57.1 %). Fifty-seven patients (50.9 %) were stage II and the remainder were stage III at the time of diagnosis. Median follow-up was 30 months (2-160). The primary site of distant metastasis was the lung (73.5 %) and the second most common site was the liver (11.7 %). The 5-year overall survival, distant metastasis-free survival, and local recurrence-free survival rates were 56.3, 53.4, and 67.2 %, respectively. Multivariate analysis showed that Eastern Cooperative Oncology Group (ECOG) performance score of II (p = 0.033), deep tumor location (p = 0.000), and development of distant metastasis (p = 0.004) were negatively correlated with overall survival, and perioperative radiotherapy and negative microscopic margins were significant factors for local control rates (p = 0.000 for each). Deep tumor location (p = 0.003) was the only adverse factor related to distant metastasis-free survival. Deep tumor location, ECOG performance score of II, and development of distant metastasis carry a poor prognostic implication on overall survival. These will aid clinicians in predicting survival and treatment decision.

  10. Tumor maligno indiferenciado disseminado. Diagnóstico ao exame oftalmológico: relato de um caso Metastatic undifferentiated malignant tumor: report of a case

    Directory of Open Access Journals (Sweden)

    Henrique Shiguekiyo Kikuta

    2001-08-01

    undifferentiated malignant neoplasm. Conclusions: This paper reports the importance of clinical history and general physical examination in the orbital affections guiding the physician to correct diagnosis and apply adequate treatment in a case in which the patient presenting multiple metastases, the ophthalmologic signs were the ones that led him to medical visit.

  11. The CIPRUS study, a nurse-led psychological treatment for patients with undifferentiated somatoform disorder in primary care: study protocol for a randomised controlled trial.

    Science.gov (United States)

    Sitnikova, Kate; Leone, Stephanie S; Zonneveld, Lyonne N L; van Marwijk, Harm W J; Bosmans, Judith E; van der Wouden, Johannes C; van der Horst, Henriëtte E

    2017-05-03

    Up to a third of patients presenting medically unexplained physical symptoms in primary care may have a somatoform disorder, of which undifferentiated somatoform disorder (USD) is the most common type. Psychological interventions can reduce symptoms associated with USD and improve functioning. Previous research has either been conducted in secondary care or interventions have been provided by general practitioners (GPs) or psychologists in primary care. As efficiency and cost-effectiveness are imperative in primary care, it is important to investigate whether nurse-led interventions are effective as well. The aim of this study is to examine the effectiveness and cost-effectiveness of a short cognitive behavioural therapy (CBT)-based treatment for patients with USD provided by mental health nurse practitioners (MHNPs), compared to usual care. In a cluster randomised controlled trial, 212 adult patients with USD will be assigned to the intervention or care as usual. The intervention group will be offered a short, individual CBT-based treatment by the MHNP in addition to usual GP care. The main goal of the intervention is that patients become less impaired by their physical symptoms and cope with symptoms in a more effective way. In six sessions patients will receive problem-solving treatment. The primary outcome is improvement in physical functioning, measured by the physical component summary score of the RAND-36. Secondary outcomes include health-related quality of life measured by the separate subscales of the RAND-36, somatization (PHQ-15) and symptoms of depression and anxiety (HADS). Problem-solving skills, health anxiety, illness perceptions, coping, mastery and working alliance will be assessed as potential mediators. Assessments will be done at 0, 2, 4, 8 and 12 months. An economic evaluation will be conducted from a societal perspective with quality of life as the primary outcome measure assessed by the EQ-5D-5L. Health care, patient and lost productivity

  12. Undifferentiated Pleomorphic Sarcoma and the Importance of Considering the Oncogenic and Immune-Suppressant Role of the Human T-Cell Lymphotropic Virus Type 1: A Case Report

    Directory of Open Access Journals (Sweden)

    Sergio Lupo

    2017-05-01

    Full Text Available IntroductionSoft-tissue sarcomas account for 0.7% of all malignant tumors, with an incidence rate of 3 per 100,000 persons/year. The undifferentiated pleomorphic sarcoma (UPS with giant cells, a high grade tumor of soft tissue, is very unusual, especially in young adults before the age of 40. Human T-cell lymphotropic virus type 1 (HTLV-1 is a human retrovirus, classified as group 1 human carcinogens by The International Agency for Research on Cancer, that causes an aggressive malignancy known as adult T-cell lymphoma/leukemia and a progressive chronic inflammatory neurological disease named HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP. HTLV-1 causes accumulation of genetic mutations in the host genome that could contribute to cellular transformation, one of the oncogenic features of HTLV-1.Case reportWe describe a case of a young woman with UPS who suffered from HAM/TSP with 3 years of evolution. In 2013, the patient started with neurological symptoms: weakness in the legs and bladder dysfunction. One year later, the patient developed a mild paraparesis in both extremities, anti-HTLV-1 antibodies were detected in plasma and in cerebrospinal fluid, and HAM/TSP was confirmed. In November 2015, a benign ganglion cyst was first suspected without intervention and by March 2016 a sarcoma was diagnosed. Three weeks after surgical resection, the tumor aroused in deep tissue and behaved aggressively, implicating a curative wide resection of the fibula, joint reconstruction, and soft-tissue graft. Histopathological examination confirmed UPS with giant cells.Concluding remarksThe unapparent subclinical immunodeficiency state due to HTLV-1 infection deserves to be considered in order to carefully monitor the possibility of developing any type of cancer. Besides, reaching an accurate and timely diagnosis of UPS can be challenging due to the difficulty in diagnosis/classification and delayed consultation. In this particular case

  13. Cardiac involvement in undifferentiated connective tissue disease at risk for systemic sclerosis (otherwise referred to as very early-early systemic sclerosis): a TDI study.

    Science.gov (United States)

    D'Alto, Michele; Riccardi, Antonella; Argiento, Paola; Di Stefano, Ilaria; Romeo, Emanuele; Iacono, Agostino Mattera; D'Andrea, Antonello; Fasano, Serena; Sanduzzi, Alessandro; Bocchino, Marialuisa; Docimo, Ludovico; Tolone, Salvatore; Russo, Maria Giovanna; Valentini, Gabriele

    2017-10-09

    Undifferentiated connective tissue disease at risk for systemic sclerosis (UCTD-risk-SSc), otherwise referred to as very early-early SSc, is a condition characterized by Raynaud's phenomenon with serum SSc marker autoantibodies and/or typical capillaroscopic findings and unsatisfying classification criteria for the disease. The aim of the present study was to assess the prevalence of right (RV) or left ventricular (LV) systolic and/or diastolic dysfunction by standard echocardiography and tissue Doppler imaging (TDI). Thirty patients with UCTD-risk-SSc (28 female, mean age 47 ± 13 years, range 21-70) and 30 age- and sex-matched controls underwent cardiac assessment by standard echocardiography and TDI. UCTD-risk-SSc patients and controls did not show any difference at standard echocardiography. Despite results falling within the respective normal ranges, TDI pointed out a mild impairment of LV and RV diastolic (E m 15 ± 4 vs. 19 ± 5, p = 0.0004; E/E m 6.1 ± 1.7 vs. 4.8 ± 1.2, p = 0.001; E t 14 ± 3 vs. 16 ± 2, p = 0.02; E t /A t 0.9 ± 0.4 vs. 1.3 ± 0.3, p = 0.002; E/E t 3.5 ± 1.2 vs. 4.2 ± 0.9, p = 0.02) and systolic function (S m 13 ± 3 vs. 15 ± 2 cm/s, p risk-SSc patients as compared to controls. Notably, a statistically significant difference also emerged in the prevalence of TDI detected E'/A' t , (71% of UCTD-risk-SSc patients vs. 19% of controls; p risk-SSc patients show a previously unrecognized, mild biventricular systolic and diastolic dysfunction as compared to controls. The pathophysiologic meaning as well the predictive value of developing overt SSc await to be elucidated.

  14. Geochemistry and mineralogy of Ogun phosphate rock

    African Journals Online (AJOL)

    user

    708 ... 2Department of Soil Science and Land Management, University of Agriculture, Abeokuta Ogun State, Nigeria. 3School of ... Suitability of direct application of phosphate rock as low cost phosphorus fertilizer for crop production must be ...

  15. Fluorine geochemistry in volcanic rock series

    DEFF Research Database (Denmark)

    Stecher, Ole

    1998-01-01

    A new analytical procedure has been established in order to determine low fluorine concentrations (30–100 ppm F) in igneous rocks, and the method has also proven successful for higher concentrations (100–4000 ppm F). Fluorine has been measured in a series of olivine tholeiites from the Reykjanes...... Peninsula, a tholeiite to rhyolitic rock series from Kerlingarfjöll, central Iceland, and an alkaline rock series from Jan Mayen that ranges from ankaramites to trachytes. Fluorine is not appreciably degassed during extrusion and appears to be insensitive to slight weathering. The olivine tholeiites from...... the Reykjanes Peninsula have F contents of 30–300 ppm and exhibit linear increases proportional to the incompatible elements K, P, and Ti. Such incompatible behaviour for F has been confirmed for the less evolved rocks of the other series. The tholeiites from Kerlingarfjöll (100–2000 ppm F) show a linear...

  16. Rock glaciers, Prealps, Vaud, Switzerland, Version 1

    Data.gov (United States)

    National Aeronautics and Space Administration — The investigated area forms part of the western lobe of the Prealps (Swiss Prealps). The 25 identified fossil rock glaciers are found mainly in the Prealpes medianes...

  17. Rock bed heat accumulators. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Riaz, M.

    1977-12-01

    The principal objectives of the research program on rock bed heat accumulators (or RBHA) are: (1) to investigate the technical and economic feasibility of storing large amounts of thermal energy (in the tens of MWt range) at high temperature (up to 500/sup 0/C) over extended periods of time (up to 6 months) using native earth or rock materials; (2) to conduct studies to establish the performance characteristics of large rock bed heat accumulators at various power and temperature levels compatible with thermal conversion systems; and (3) to assess the materials and environmental problems associated with the operation of such large heat accumulators. Results of the study indicate that rock bed heat accumulators for seasonal storage are both technically and economically feasible, and hence could be exploited in various applications in which storage plays an essential role such as solar power and total energy systems, district and cogeneration heating systems.

  18. Mechanical dispersion in fractured crystalline rock systems

    International Nuclear Information System (INIS)

    Lafleur, D.W.; Raven, K.G.

    1986-12-01

    This report compiles and evaluates the hydrogeologic parameters describing the flow of groundwater and transport of solutes in fractured crystalline rocks. This report describes the processes of mechanical dispersion in fractured crystalline rocks, and compiles and evaluates the dispersion parameters determined from both laboratory and field tracer experiments. The compiled data show that extrapolation of the reliable test results performed over intermediate scales (10's of m and 10's to 100's of hours) to larger spatial and temporal scales required for performance assessment of a nuclear waste repository in crystalline rock is not justified. The reliable measures of longitudinal dispersivity of fractured crystalline rock are found to range between 0.4 and 7.8 m

  19. ROCK GLACIERS IN THE KOLYMA HIGHLAND

    Directory of Open Access Journals (Sweden)

    A. A. Galanin

    2012-01-01

    Full Text Available Based on remote mapping and field studies inGrand Rapids, Tumansky,Hasynsky,Del-Urechen Ridges as well as Dukchinsky and Kilgansky Mountain Massifs there were identified about 1160 landforms which morphologically are similar to the rock glaciers or they develop in close association with them. Besides tongue-shaped cirque rock glaciers originated due to ablation, a large number of lobate-shaped slope-associated rock glaciers were recognized. Significant quantity of such forms are developing within the active neotectonic areas, in zones of seismic-tectonic badland and in association with active earthquakes-controlling faults. Multiplication of regional data on volcanic-ash-chronology, lichenometry, Schmidt Hammer Test, pollen spectra and single radiocarbon data, most of the active rock glaciers were preliminary attributed to the Late Holocene.

  20. Pore-scale analysis of electrical properties in thinly bedded rock using digital rock physics

    International Nuclear Information System (INIS)

    Sun, Jianmeng; Zhao, Jianpeng; Liu, Xuefeng; Chen, Hui; Jiang, LiMing; Zhang, JinYan

    2014-01-01

    We investigated the electrical properties of laminated rock consist of macro-porous layers and micro-porous layers based on digital rock technology. Due to the bedding effect and anisotropy, traditional Archie equations cannot well describe the electrical behavior of laminated rock. The RI-Sw curve of laminated rock shows a nonlinear relationship. The RI-Sw curve can be divided into two linear segments with different saturation exponent. Laminated sand-shale sequences and laminated sands of different porosity or grain size will yield macroscopic electrical anisotropy. Numerical simulation and theoretical analysis lead to the conclusion that electrical anisotropy coefficient of laminated rock is a strong function of water saturation. The function curve can be divided into three segments by the turning point. Therefore, the electrical behavior of laminated rock should be considered in oil exploration and development. (paper)

  1. Stratigraphic structure of the B1 Tertiary tectonostratigraphic unit in eastern Slovenia

    Directory of Open Access Journals (Sweden)

    Bogomir Jelen

    2002-06-01

    Full Text Available High inconsistency and incoherence in the stratigraphy of the Slovenian upper Paleogene and lower Miocene have remained unsolved in the past 150 years. To solve the problem, we tried to rigorously conduct the authentic Galilei’s scientific method. Steps of logical and empirical verification confirmed the existence of the posited B1 Tertiary tectonostratigraphic unit, and a general chronostratigraphic model of new positional relationships of lithologic units resulted from rather good biochronostratigraphic resolution achieved by nannoplankton and planktonic foraminifera biostratigraphy. The application of principles of newly developed fields in science helped us to avoid errors in transmission of messages (to reduce noise from the source (rock to the concept formation,which had been done previously. This in turn has strongly reduced inconsistency andincoherence (high information entropy = uncertainty. The released amount of information enabled us to answer also questions that reached beyond the original difficulty, e.g.: is the tectonostratigraphic structure of eastern Slovenia a manifestation of plate tectonics processes, and of which ones, are theories of continental escape in the Alps and associated dissection and offset of the formerly uniform Slovenian-Hungarian Paleogene basin tenableor not, are then there in the B1 stratigraphic equivalents of the Hungarian Paleogene basin formations, where are the important Eocene / Oligocene, Paleogene / Neogene, Rupelian / Chattian and Kiscellian / Egerian boundaries in Slovenia, and is there acontinuation of the B1 in Croatia and in the Mid-Hungarian tectonic zone?

  2. Acoustics in rock and pop music halls

    DEFF Research Database (Denmark)

    Adelman-Larsen, Niels Werner; Thompson, Eric Robert; Gade, Anders Christian

    2007-01-01

    The existing body of literature regarding the acoustic design of concert halls has focused almost exclusively on classical music, although there are many more performances of rhythmic music, including rock and pop. Objective measurements were made of the acoustics of twenty rock music venues...... frequency sounds are typically highly amplified, they play an important role in the subjective ratings and the 63-Hz-band must be included in objective measurements and recommendations....

  3. Developing a Virtual Rock Deformation Laboratory

    Science.gov (United States)

    Zhu, W.; Ougier-simonin, A.; Lisabeth, H. P.; Banker, J. S.

    2012-12-01

    Experimental rock physics plays an important role in advancing earthquake research. Despite its importance in geophysics, reservoir engineering, waste deposits and energy resources, most geology departments in U.S. universities don't have rock deformation facilities. A virtual deformation laboratory can serve as an efficient tool to help geology students naturally and internationally learn about rock deformation. Working with computer science engineers, we built a virtual deformation laboratory that aims at fostering user interaction to facilitate classroom and outreach teaching and learning. The virtual lab is built to center around a triaxial deformation apparatus in which laboratory measurements of mechanical and transport properties such as stress, axial and radial strains, acoustic emission activities, wave velocities, and permeability are demonstrated. A student user can create her avatar to enter the virtual lab. In the virtual lab, the avatar can browse and choose among various rock samples, determine the testing conditions (pressure, temperature, strain rate, loading paths), then operate the virtual deformation machine to observe how deformation changes physical properties of rocks. Actual experimental results on the mechanical, frictional, sonic, acoustic and transport properties of different rocks at different conditions are compiled. The data acquisition system in the virtual lab is linked to the complied experimental data. Structural and microstructural images of deformed rocks are up-loaded and linked to different deformation tests. The integration of the microstructural image and the deformation data allows the student to visualize how forces reshape the structure of the rock and change the physical properties. The virtual lab is built using the Game Engine. The geological background, outstanding questions related to the geological environment, and physical and mechanical concepts associated with the problem will be illustrated on the web portal. In

  4. Analyzing Architecture of Mithraism Rock Temples

    OpenAIRE

    Zohre AliJabbari

    2017-01-01

    This analyzes the architecture of rock temples of West and Northwest of Iran, as well as factors influencing their formation. The creation of rock architecture in this area of Iran is influenced by the religious, geographical and political atmosphere of their time. Most of these structures are formed by dominated empires in the first millennium BC. And in some works we are observing their continuity in later periods and change in their functions. One of the reasons that have attracted man to ...

  5. Digital Rock Studies of Tight Porous Media

    Energy Technology Data Exchange (ETDEWEB)

    Silin, Dmitriy [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2012-08-07

    This technical report summarizes some recently developed approaches to studies of rock properties at a pore scale. Digital rock approach is complementary to laboratory and field studies. It can be especially helpful in situations where experimental data are uncertain, or are difficult or impossible to obtain. Digitized binary images of the pore geometries of natural rocks obtained by different imaging techniques are the input data. Computer-generated models of natural rocks can be used instead of images in a case where microtomography data are unavailable, or the resolution of the tools is insufficient to adequately characterize the features of interest. Simulations of creeping viscous flow in pores produce estimates of Darcy permeability. Maximal Inscribed Spheres calculations estimate two-phase fluid distribution in capillary equilibrium. A combination of both produce relative permeability curves. Computer-generated rock models were employed to study two-phase properties of fractured rocks, or tight sands with slit-like pores, too narrow to be characterized with micro-tomography. Various scenarios can simulate different fluid displacement mechanisms, from piston-like drainage to liquid dropout at the dew point. A finite differences discretization of Stokes equation is developed to simulate flow in the pore space of natural rocks. The numerical schemes are capable to handle both no-slip and slippage flows. An upscaling procedure estimates the permeability by subsampling a large data set. Capillary equilibrium and capillary pressure curves are efficiently estimated with the method of maximal inscribed spheres both an arbitrary contact angle. The algorithms can handle gigobytes of data on a desktop workstation. Customized QuickHull algorithms model natural rocks. Capillary pressure curves evaluated from computer-generated images mimic those obtained for microtomography data.

  6. Acoustics in rock and pop music halls

    DEFF Research Database (Denmark)

    Adelman-Larsen, Niels Werner; Thompson, Eric Robert; Gade, Anders Christian

    2007-01-01

    The existing body of literature regarding the acoustic design of concert halls has focused almost exclusively on classical music, although there are many more performances of rhythmic music, including rock and pop. Objective measurements were made of the acoustics of twenty rock music venues in D...... frequency sounds are typically highly amplified, they play an important role in the subjective ratings and the 63-Hz-band must be included in objective measurements and recommendations....

  7. Nuclear power in rock. Principal report

    International Nuclear Information System (INIS)

    1977-06-01

    In September 1975 the Swedish Government directed the Swedish State Power Board to study the question of rock-siting nuclear power plants. The study accounted for in this report aims at clarifying the advantages and disadvantages of siting a nuclear power plant in rock, compared to siting on ground level, considering reactor safety, war protection and sabotage. The need for nuclear power production during war situations and the closing down of nuclear power plants after terminated operation are also dealt with. (author)

  8. The Rock that Hit New York

    Energy Technology Data Exchange (ETDEWEB)

    Meade, Roger Allen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Keksis, August Lawrence [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-10-03

    On January 12, 1975, a rock seemed to fall from the sky over New York State’s Schoharie County hitting the tractor of a local farmer, who was “preparing his fields for spring planting.” As the farmer later described the event to a reporter from the UFO INVESTIGATOR, the object glanced off the tractor, fell to the ground, and melted its way through a patch of ice that was two and one half inches thick. The farmer, Leonard Tillapaugh, called the county sheriff, Harvey Stoddard, who recovered the rock, noting that it “was still warm.” Why and how a sample of the rock came to Los Alamos is not known. However, it captivated a wide Laboratory audience, was subjected to rigorous testing and evaluation. Los Alamos used the scientific method in the manner promoted by Hynek. Did Los Alamos solve the mystery of the rock’s origin? Not definitively. Although the exact origin could not be determined, it was shown conclusively that the rock was not from outer space. With that said, the saga of Rock that hit New York came to an end. Nothing more was said or written about it. The principals involved have long since passed from the scene. The NICAP ceased operations in 1980. And, the rock, itself, has disappeared.

  9. Sexism and Sexual Harassment in Tertiary Institutions | Akpotor ...

    African Journals Online (AJOL)

    Sexual harassment is a recurring decimal in tertiary institutions. The paper therefore investigates the effects of sexual harassment on the academic performance of female students, using Delta State University, Abraka, as case study. The participants were randomly selected 200level – 500level students from various ...

  10. Sexual Harassment in Tertiary Science: Implications for Gender Equity

    African Journals Online (AJOL)

    The paper focuses on the incidence of sexual harassment in tertiary science education and its attendant effects on students and academics. Data from a survey of six higher institutions comprising two universities, two colleges of education and two polytechnics was used. Results indicate high rate of sexual harassment of ...

  11. A sequence of events across the Cretaceous-Tertiary boundary

    NARCIS (Netherlands)

    Smit, J.; Romein, A.J.T.

    1985-01-01

    The lithological and biological sequence of events across the Cretaceous-Tertiary (K/T), as developed in thick and complete landbased sections and termed the standard K/T event sequence, is also found in many DSDP cores from all over the globe. Microtektite-like spherules have been found in

  12. Effect of health education on knowledge and attitude of tertiary ...

    African Journals Online (AJOL)

    Background: In order to make good decisions about their sexual and reproductive health, young people need reliable information. This study assessed the effect of health education on the knowledge and attitude of tertiary school students towards sexually transmitted infections. Methods: The study employed a ...

  13. Learning to teach mathematical modelling in secondary and tertiary education

    Science.gov (United States)

    Ferri, Rita Borromeo

    2017-07-01

    Since 2003 mathematical modelling in Germany is not only a topic for scientific disciplines in university mathematics courses, but also in school starting with primary school. This paper shows what mathematical modelling means in school and how it can be taught as a basis for complex modeling problems in tertiary education.

  14. tertiary education trust fund (tetfund) and the management of ...

    African Journals Online (AJOL)

    PROF EKWUEME

    The paper examines the role of the Tertiary Education Trust Fund (TETFund) in the management of. University education in Nigeria. A brief history of University education in Nigeria as well as the creation of TETFund was examined. Also the paper was guided with the use the Management by Objectives theory developed by ...

  15. Integrated Identity and Access Management System for Tertiary ...

    African Journals Online (AJOL)

    Integrated Identity and Access Management System for Tertiary Institutions in Developing Countries. BU Stephen, GA Chukwudebe, CP Ezenkwu. Abstract. Issuance of disparate identifiers to students, manual method of student identity management and access control and the unavailability of actionable information on ...

  16. Obesity and associated factors in young adults attending tertiary ...

    African Journals Online (AJOL)

    Obesity and associated factors in young adults attending tertiary institutions in south-eastern Nigeria. ... A validated questionnaire on sociodemographic, dietary and lifestyle factors was used. Variables studied included body mass index ... Keywords: association, obesity, overweight, socio-demographic factors, young adults ...

  17. Tertiary syphilis in the lumbar spine: a case report.

    Science.gov (United States)

    Bai, Yang; Niu, Feng; Liu, Lidi; Sha, Hui; Wang, Yimei; Zhao, Song

    2017-07-24

    The incidence of tertiary syphilis involvement in the spinal column with destructive bone lesions is very rare. It is difficult to establish the correct diagnosis from radiographs and histological examination alone. Limited data are available on surgical treatment to tertiary syphilitic spinal lesions. In this article, we report a case of tertiary syphilis in the lumbar spine with osteolytic lesions causing cauda equina compression. A 44-year-old man who suffered with low back pain for 6 months and progressive radiating pain at lower extremity for 1 week. Radiologic findings showed osteolytic lesion and new bone formation in the parts of the bodies of L4 and L5. Serum treponema pallidum hemagglutination (TPHA) test was positive. A surgery of posterior debridement, interbody and posterolateral allograft bone fusion with instrumentation from L3 to S1 was performed. The low back pain and numbness abated after operation. But the follow-up radiographs showed absorption of the bone grafts and failure of instrumentation. A Charcot's arthropathy was formed between L4 and L5. It is challenging to diagnose the tertiary syphilis in the spine. Surgery is a reasonable auxiliary method to antibiotic therapy for patients who suffered with neuropathy. Charcot's arthropathy should be considered as an operative complication.

  18. Perception of patients attending a tertiary hospital in Nigeria about ...

    African Journals Online (AJOL)

    Background: Criteria for a good dental practice as expressed by patients have influence on their behavior in terms of compliance with clinical advice, less pain and anxiety and more utilization of dental care. Objective: To assess the opinion of patients attending the dental clinic of a tertiary hospital Southwestern, Nigeria ...

  19. Caesarean delivery: An experience from a tertiary institution in North ...

    African Journals Online (AJOL)

    Objective: To assess the overall caesarean section (CS) rate, indications and outcomes in a tertiary hospital in Northwestern Nigeria. Materials and Methods: A cross-sectional study carried out over a period of two years. All patients who had caesarean section at any time within the day were noted and followed up till ...

  20. Motivation in vocational education: a reform issue in tertiary ...

    African Journals Online (AJOL)

    Working in a non-motivating environment is a nagging issue in various tertiary institutions in Cross River State .This dampens staff morale a great deal. However, the provision of motivation in work places will be a great boost to staff morale especially in Vocational Education. This paper discusses the meaning of motivation, ...

  1. Self care activities among patients with diabetes attending a tertiary ...

    African Journals Online (AJOL)

    Self care activities among patients with diabetes attending a tertiary care hospital in Mangalore Karnataka, India. ... Conclusions: Self‑care practices were found to be unsatisfactory in almost all aspects except for blood sugar monitoring and treatment adherence. As these practices are essential for prevention of ...

  2. Auditing surgical service provision at a South African tertiary institution

    African Journals Online (AJOL)

    Auditing surgical service provision at a South African tertiary institution: Implications for the development of district services. ... A total of 1272 (30.5%) operative procedures performed were assessed as district-level operations. The time intervals of 07:00–07:59 and 17:00–17:59 were identified as the time periods during ...

  3. Septic Abortion Managed in a Tertiary Hospital in West Bengal ...

    African Journals Online (AJOL)

    Background: Septic abortion is still a challenging problem and a major cause of maternal mortality and morbidity in developing countries. Aim: The present study was conducted to estimate incidence, causes, risk factors, associated microorganisms, and treatment modalities of cases of septic abortion managed in a tertiary ...

  4. Design and development of a tertiary institutions decision support ...

    African Journals Online (AJOL)

    MySQL database server was used to manage all the data in the application. The Joint Admissions and Matriculation Board (JAMB) Brochure was used extensively in order to give current information about the courses and universities available in Nigeria. Keyword: Tertiary institutions, Decision Support System, Unified ...

  5. Automated Stock Control System for Bookshops in Tertiary Institutions

    African Journals Online (AJOL)

    PROF. O. E. OSUAGWU

    2013-09-01

    Sep 1, 2013 ... Abstract. The recent need for automated stock control system for bookshops in tertiary institutions was generated by unequal availability of books and stiff scarcity of books in some areas while in other areas books are being wasted or unsold. This research has made use of distributed database systems in ...

  6. Drug Production in Tertiary Health Institutions – Needs, Constraints ...

    African Journals Online (AJOL)

    The use of questionnaires was employed in the study covering all pharmacists in the pharmaceutical services department, pharmacy technicians and quality control technologist in the drug production unit of the hospital. It was unanimously agreed by the respondents that local drug production was necessary in tertiary ...

  7. managing tertiary institutions for the promotion of lifelong learning in ...

    African Journals Online (AJOL)

    Global Journal

    The study investigated ways of managing tertiary institutions for the promotion of lifelong learning in. Cross River State, Nigeria. One research question was raised and one hypothesis formulated to guide the study. Multistage sampling procedure was adopted for the study. Stratified random sampling technique and simple ...

  8. Management of necrotizing enterocolitis: experience at a tertiary ...

    African Journals Online (AJOL)

    Management of necrotizing enterocolitis: experience at a tertiary care hospital in Oman. Kirtikumar J. Rathod a. , Asfaq A. Khan b. , Mathew Kripail b. , Muhammad Fazallulah b. ,. Zainab Al Balushi a and Mohamed Abdellatif b. Introduction Necrotizing enterocolitis (NEC) is the most common surgical emergency in the ...

  9. Building Social Justice among Academic Staffs of Tertiary ...

    African Journals Online (AJOL)

    The study investigated the influence of acculturation, networking and school management support on social justice building among university academic staffs of tertiary institutions. A descriptive survey research design was adopted for the study. The sample for the study was three hundred (300) randomly selected academic ...

  10. Sexual harassment in tertiary institutions: A comparative perspective

    OpenAIRE

    Joseph Janice

    2015-01-01

    Sexual harassment is not a new phenomenon in tertiary institutions. It has been receiving considerable attention in research and the media and public awareness has increased dramatically. However, the term sexual harassment is not used uniformly across the globe because countries have defined it differently. Consequently, prevalence of sexual harassment in education varies across cultures. This paper examines sexual harassment from a comparative perspective...

  11. Impact assessment of electronic mass communication in a tertiary ...

    African Journals Online (AJOL)

    The proliferation of computer networks and Internet access opened new communication channels such as blogs, websites, e-mail, social media and mobile apps. In view of the current economic recession in Nigeria, tertiary institutions are turning to information technology for educational and communications solutions to ...

  12. Outcome of Teenage Pregnancy at a Tertiary Hospital in Abakaliki ...

    African Journals Online (AJOL)

    education, women enlightenment and empowerment will be essential in reducing the problems of teenage pregnancy. KEY W ORDS: Abakaliki, outcome, teenage pregnancy, tertiary hospital. INTRODUCTION. Teenage pregnancy dates back to the early centuries and a famous teenage pregnancy in history was Mary,.

  13. Epidemiology of death in the emergency department of a tertiary ...

    African Journals Online (AJOL)

    A recorded death rate of 8.6% is high, suspected contributory factors include systemic deficiencies such as the lack of a trauma system, prehospital care; late presentation, the role of chemist operators, traditional healers, and delayed referral systems. Key words: Epidemiology of death, emergency department, tertiary health ...

  14. Genesis of some tertiary Indian coals from the chemical composition ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science; Volume 123; Issue 7. Genesis of some tertiary Indian coals from the chemical composition of ash – a statistical approach: Part 1. Arpita Sharma Ananya Saikia Puja Khare B P Baruah. Volume 123 Issue 7 October 2014 pp 1705-1715 ...

  15. Analysis of Cutaneous Adverse Drug Reactions at a Tertiary Care ...

    African Journals Online (AJOL)

    Erah

    Tertiary Care Hospital – a Prospective Study. SP Shah*, MK Desai and ... drug reactions manifest as skin rashes and/or eruptions. The incidence ..... Safety Monitoring on. Medicinal Products. Geneva (Switzerland):. Office of Publications, World Health. Organization; 2002. 6. Hartwig SC, Siegel J, Schneider PJ. Preventability.

  16. Tertiary Institutions, Entrepreneurship Education and Youth Empowerment in Nigeria

    Science.gov (United States)

    Olasunkanmi, Abari Ayodeji; Olufunke, Oyetola Idowu; Adetayo, Okunuga Adedapo

    2013-01-01

    Entrepreneurship Education has recently become a global phenomenon in the development of world youths for self employment and self-reliance. The Nigerian nation cannot afford to be left out and left behind in this new trend in education both at the secondary and tertiary levels. However, while the Universal Basic Education (UBE) curriculum has…

  17. Counselling for Sustainable Peace in Tertiary Institutions in Nigeria

    Science.gov (United States)

    Nduka-Ozo, Stella Ngozi

    2016-01-01

    This study reviewed the nature of peace in Tertiary Institutions in Nigeria using Ebonyi State University as a case study. The purpose of the study was to review the various factors responsible for lack of peace. The sample was drawn from the three hundred level students of the Faculty of Education. Thirty students were selected from each of the…

  18. Automated Stock Control System for Bookshops in Tertiary Institutions

    African Journals Online (AJOL)

    The recent need for automated stock control system for bookshops in tertiary institutions was generated by unequal availability of books and stiff scarcity of books in some areas while in ... This approach provides for faster response times for users because the database is local to each business unit within the organization.

  19. Montane pollen from the Tertiary of NW. Borneo

    NARCIS (Netherlands)

    Muller, J.

    1966-01-01

    In NW. Borneo thick series of Tertiary sediments occur which are rich in fossil pollen and spores. The majority of these plant microfossils were derived from the various types of tropical lowland vegetation such as mangrove (Muller, 1964), mixed peat swamp forest and mixed Dipterocarp forest. Some

  20. Omalizumab use during pregnancy for CIU: a tertiary care experience.

    Science.gov (United States)

    Cuervo-Pardo, L; Barcena-Blanch, M; Radojicic, C

    2016-07-01

    The treatment of antihistamine and steroid resistant Chronic Idiopathic Urticaria (CIU) during pregnancy poses a challenge due to teratogenicity of immunosuppressants. Omalizumab is a recently FDA approved therapy for CIU and is classified as pregnancy category B. We present an initial series of subjects treated at a tertiary care center for antihistamine and steroid resistant CIU with omalizumab who became pregnant during therapy.