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Sample records for understanding tgfu approach

  1. Teaching Games and Sport for Understanding: Exploring and Reconsidering its Relevance in Physical Education

    Science.gov (United States)

    Stolz, Steven; Pill, Shane

    2014-01-01

    Over 30 years ago the original teaching games for understanding (TGfU) proposition was published in a special edition of the Bulletin of Physical Education (Bunker and Thorpe, 1982). In that time TGfU has attracted significant attention from a theoretical and pedagogical perspective as an improved approach to games and sport teaching in physical…

  2. The Effect of Teaching Games of Understanding as a Coaching Instruction had on Adjust, Cover and Heart Rate among Malaysian and Indian Junior Hockey Players

    Directory of Open Access Journals (Sweden)

    Sanmuga Nathan

    2017-06-01

    Full Text Available The field hockey coaching process across both Malaysia and India favours a traditional, coach-centred approach of mastering technical skills in terms of game play parameters, fitness, intensity, and load training, whereas a tactical- and player-centred pedagogical approach still takes a backseat. On the other hand, the Teaching Games for Understanding (TGfU model offers tactical-cognitive instruction and is gaining international recognition for its ability to produce intelligent players via a problem-solving approach in game play. Therefore, the purpose of this quasi-experimental study was to investigate the effect of TGfU compared to skill mastery instruction, termed as Skill Drill Technical (SDT, among Malaysian and Indian elite junior hockey players in term of the game play attributes of adjust and cover in 5 vs. 5 small-sided game play and game play intensity via heart rate (HR at different points of game play. A total of n = 60 players with an average age of 15 ± 1.03 was selected via simple random sampling from both countries involved in this study and assigned equally to groups, with 15 per group for TGfU and for SDT across Malaysia and India. Gathered data were analysed using the ANOVA and ANCOVA techniques. Findings indicated that there were no significant differences for adjust in 5 vs. 5 game play between TGfU and SDT across Malaysia and India after the intervention. For cover, there was significant improvement for Malaysian players using the TGfU model compared to SDT. In contrast, there was no significant difference between these two models among the Indian players after the intervention. There was significant difference between these two models in terms of warm-up HR across the two countries, and HR was higher via TGfU. For HR immediately after the 5 vs. 5 game play intervention and HR after three minutes’ recovery, Indian players with TGfU recorded a higher and significant difference compared to SDT. However, findings indicated

  3. Factors Influencing Pre-Service Teachers' Perception of Teaching Games for Understanding: A Constructivist Perspective

    Science.gov (United States)

    Wang, Lijuan; Ha, Amy S.

    2012-01-01

    This study aims to examine the factors influencing pre-service Physical Education (PE) teachers' perception of a specific constructivist approach--Teaching Games for Understanding (TGfU) in Hong Kong. By adopting a qualitative approach, 20 pre-service PE teachers were recruited for individual semi-structured interviews. Deductive data analysis was…

  4. Teaching Games for Understanding in American High-School Soccer: A Quantitative Data Analysis Using the Game Performance Assessment Instrument

    Science.gov (United States)

    Harvey, Stephen; Cushion, Christopher J.; Wegis, Heidi M.; Massa-Gonzalez, Ada N.

    2010-01-01

    Background: Previous research examining the effectiveness of the Teaching Games for Understanding (TGfU) approach has been equivocal. This has been hampered by a dependence on a comparative (i.e., "which method is best?") theoretical framework. An alternative "practice-referenced" framework has the potential to examine the effectiveness of TGfU…

  5. Old Wine in New Bottles: A Response to Claims That Teaching Games for Understanding Was Not Developed as A Theoretically Based Pedagogical Framework

    Science.gov (United States)

    Harvey, Stephen; Pill, Shane; Almond, Len

    2018-01-01

    Background: Teaching games for understanding (TGfU) has stimulated so much attention, research and debate since the 1980s that it is easy for its origins to become refracted and misunderstood. For example, in a recent edition of the "Physical Education and Sport Pedagogy" journal there was paper arguing a constraints-led approach (CLA)…

  6. The Games Concept Approach (GCA) as a Mandated Practice: Views of Singaporean Teachers

    Science.gov (United States)

    Rossi, Tony; Fry, Joan M.; McNeill, Mike; Tan, Clara W. K.

    2007-01-01

    This paper reports on the views of Singaporean teachers of a mandated curriculum innovation aimed at changing the nature of games pedagogy within the physical education curriculum framework in Singapore. Since its first appearance over 20 years ago, Teaching Games for Understanding (TGfU), as an approach to games pedagogy has gathered support…

  7. Working towards Legitimacy: Two Decades of Teaching Games for Understanding

    Science.gov (United States)

    Griffin, Linda L.; Brooker, Ross; Patton, Kevin

    2005-01-01

    Time and acceptance are criterion often used to measure the legitimacy and worth of an idea. Two decades have passed since the first publications that introduced Teaching Games for Understanding (TGfU) as a means to conceptualize games teaching and learning. For over two decades various professionals have advocated for TGfU as a sound idea, which…

  8. Learning Informally to Use Teaching Games for Understanding: The Experiences of a Recently Qualified Teacher

    Science.gov (United States)

    O'Leary, Nick

    2014-01-01

    This article reports on a study of one recently qualified teacher's employment of the Teaching Games for Understanding (TGfU) model in a UK secondary school. The study sought to examine how the teacher, not formally educated in its use, delivered TGfU and to identify those factors that led to this interpretation of the model. Occupational…

  9. Learning Informally to Use the "Full Version" of Teaching Games for Understanding

    Science.gov (United States)

    O'Leary, Nick

    2016-01-01

    This paper examines an experienced teacher's employment of the teaching games for understanding (TGfU) model in a UK secondary school. The study sought to investigate how the teacher delivered TGfU and those factors that influenced his informal learning of this instructional model. Occupational socialisation was utilised to determine the factors…

  10. Teaching Games for Understanding: A Comprehensive Approach to Promote Student's Motivation in Physical Education.

    Science.gov (United States)

    Hortigüela Alcalá, David; Hernando Garijo, Alejandra

    2017-10-01

    It seems important to consider students' attitudes towards physical education (PE), and the way they learn sports. The present study examines students' perceptions of motivation and achievement in PE after experiencing three consecutive sport units. Two hundred and thirty seven students from the 1st, 2nd, 3rd, and 4th grade in a high school in Burgos (Spain) and two teachers agreed to participate. They were divided into two groups in order to compare two instructional approaches. The experimental group (A), 128 students, experienced Teaching Games for Understanding (TGfU), while the control group (B), 109 students, experienced a technical-traditional approach. Each group was taught by a different teacher. The study followed a mixed-method research design with quantitative (questionnaire) and qualitative (interview) data. Results revealed that group A showed greater motivation and achievement in PE than group B. Significant differences were found in achievement. Participants with better academic results in group A were more positive in sport participation. Meanwhile, students who practiced more extracurricular sports in group B were more actively involved in sport. Teachers disagreed greatly on the way sport should be taught in PE.

  11. Top 10 Research Questions Related to Teaching Games for Understanding.

    Science.gov (United States)

    Memmert, Daniel; Almond, Len; Bunker, David; Butler, Joy; Fasold, Frowin; Griffin, Linda; Hillmann, Wolfgang; Hüttermann, Stefanie; Klein-Soetebier, Timo; König, Stefan; Nopp, Stephan; Rathschlag, Marco; Schul, Karsten; Schwab, Sebastian; Thorpe, Rod; Furley, Philip

    2015-01-01

    In this article, we elaborate on 10 current research questions related to the "teaching games for understanding" (TGfU) approach with the objective of both developing the model itself and fostering game understanding, tactical decision making, and game-playing ability in invasion and net/wall games: (1) How can existing scientific approaches from different disciplines be used to enhance game play for beginners and proficient players? (2) How can state-of-the-art technology be integrated to game-play evaluations of beginners and proficient players by employing corresponding assessments? (4) How can complexity thinking be utilized to shape day-to-day physical education (PE) and coaching practices? (5) How can game making/designing be helpfully utilized for emergent learning? (6) How could purposeful game design create constraints that enable tactical understanding and skill development through adaptive learning and distributed cognition? (7) How can teacher/coach development programs benefit from game-centered approaches? (8) How can TGfU-related approaches be implemented in teacher or coach education with the goal of facilitating preservice and in-service teachers/coaches' learning to teach and thereby foster their professional development from novices to experienced practitioners? (9) Can the TGfU approach be considered a helpful model across different cultures? (10) Can physical/psychomotor, cognitive, affective/social, and cultural development be fostered via TGfU approaches? The answers to these questions are critical not only for the advancement of teaching and coaching in PE and sport-based clubs, but also for an in-depth discussion on new scientific avenues and technological tools.

  12. Breaking down the Barriers: Insights into Using a Student Centred Games Approach in Australian and Malaysian Pre-Service Settings

    Science.gov (United States)

    Peters, Jacqui; Shuck, Lisa

    2009-01-01

    Teacher education in physical education has received much attention in literature over the years. Vying for our attention as teacher educators in physical education are a range of pedagogical models. Teaching Games for Understanding (TGfU) is one such model. This autoethnographical account explores our teaching of TGfU in two culturally diverse…

  13. Top 10 Research Questions Related to Teaching Games for Understanding

    Science.gov (United States)

    Memmert, Daniel; Almond, Len; Bunker, David; Butler, Joy; Fasold, Frowin; Griffin, Linda; Hillmann, Wolfgang; Hüttermann, Stefanie; Klein-Soetebier, Timo; König, Stefan; Nopp, Stephan; Rathschlag, Marco; Schul, Karsten; Schwab, Sebastian; Thorpe, Rod; Furley, Philip

    2015-01-01

    In this article, we elaborate on 10 current research questions related to the “teaching games for understanding” (TGfU) approach with the objective of both developing the model itself and fostering game understanding, tactical decision making, and game-playing ability in invasion and net/wall games: (1) How can existing scientific approaches from different disciplines be used to enhance game play for beginners and proficient players? (2) How can state-of-the-art technology be integrated to game-play evaluations of beginners and proficient players by employing corresponding assessments? (4) How can complexity thinking be utilized to shape day-to-day physical education (PE) and coaching practices? (5) How can game making/designing be helpfully utilized for emergent learning? (6) How could purposeful game design create constraints that enable tactical understanding and skill development through adaptive learning and distributed cognition? (7) How can teacher/coach development programs benefit from game-centered approaches? (8) How can TGfU-related approaches be implemented in teacher or coach education with the goal of facilitating preservice and in-service teachers/coaches’ learning to teach and thereby foster their professional development from novices to experienced practitioners? (9) Can the TGfU approach be considered a helpful model across different cultures? (10) Can physical/psychomotor, cognitive, affective/social, and cultural development be fostered via TGfU approaches? The answers to these questions are critical not only for the advancement of teaching and coaching in PE and sport-based clubs, but also for an in-depth discussion on new scientific avenues and technological tools. PMID:26452580

  14. Teaching Physical Literacy to Promote Healthy Lives: TGfU and Related Approaches

    Science.gov (United States)

    Doozan, Ashley; Bae, Mihae

    2016-01-01

    The knowledge acquired in physical education classes should provide for an increase in physical activity and promote interest in healthier lifestyles. Despite the importance of physical literacy developed in physical education classes, physical education is not perceived as important, and funding for physical education has decreased. This paper…

  15. Understanding Progress: A Heterodox Approach

    Directory of Open Access Journals (Sweden)

    Blanca Lemus

    2013-01-01

    Full Text Available This paper examines the possibility of understanding and measuring well-being as a result of “progress” on the basis of today’s dominant epistemological framework. Market criteria distort social values by allowing purchasing power to define priorities, likening luxury goods to basic needs; in the process they reinforce patterns of discrimination against disadvantaged social groups and women, introducing fatal distortions into the analysis. Similarly, because there are no appropriate mechanisms to price natural resources adequately, the market overlooks the consequences of the abuse of natural resources, degrading the quality of life, individually and collectively, or—in the framework of Latin American indigenous groups—foreclosing the possibility of “living well”. We critique the common vision of the official development discourse that places its faith on technological innovations to resolve these problems. The analysis points to the need for new models of social and environmental governance to promote progress, approaches like those suggested in the paper that are inconsistent with public policies currently in place. At present, the social groups forging institutions to assure their own well-being and ecological balance are involved in local processes, often in opposition to the proposals of the political leaders in their countries.

  16. Innovative approach towards understanding optics

    Science.gov (United States)

    Garg, Amit; Bharadwaj, Sadashiv Raj; Kumar, Raj; Shudhanshu, Avinash Kumar; Verma, Deepak Kumar

    2016-01-01

    Over the last few years, there has been a decline in the students’ interest towards Science and Optics. Use of technology in the form of various types of sensors and data acquisition systems has come as a saviour. Till date, manual routine tools and techniques are used to perform various experimental procedures in most of the science/optics laboratories in our country. The manual tools are cumbersome whereas the automated ones are costly. It does not enthuse young researchers towards the science laboratories. There is a need to develop applications which can be easily integrated, tailored at school and undergraduate level laboratories and are economical at the same time. Equipments with advanced technologies are available but they are uneconomical and have complicated working principle with a black box approach. The present work describes development of portable tools and applications which are user-friendly. This is being implemented using open-source physical computing platform based on a simple low cost microcontroller board and a development environment for writing software. The present paper reports the development of an automated spectrometer, an instrument used in almost all optics experiments at undergraduate level, and students’ response to this innovation. These tools will inspire young researchers towards science and facilitate development of advance low cost equipments making life easier for Indian as well as developing nations.

  17. Understanding the Steiner Waldorf Approach: Early Years Education in Practice. Understanding the... Approach

    Science.gov (United States)

    Nicol, Janni; Taplin, Jill

    2012-01-01

    Understanding the Steiner Waldorf Approach is a much needed source of information for those wishing to extend and consolidate their understanding of the Steiner Waldorf High Scope Approach. It will enable the reader to analyse the essential elements of the Steiner Waldorf Approach to early childhood and its relationship to quality early years…

  18. Understanding the Reggio Approach: Early Years Education in Practice. Second Edition. Understanding the... Approach

    Science.gov (United States)

    Thornton, Linda; Brunton, Pat

    2009-01-01

    "Understanding the Reggio Approach" is a much needed source of information for those wishing to extend and consolidate their understanding of the Reggio Approach. Analysing the essential elements of the Reggio Approach to early childhood and its relationship to quality early years practice, this new edition is fully updated with the…

  19. Student Approaches to Achieving Understanding--Approaches to Learning Revisited

    Science.gov (United States)

    Fyrenius, Anna; Wirell, Staffan; Silen, Charlotte

    2007-01-01

    This article presents a phenomenographic study that investigates students' approaches to achieving understanding. The results are based on interviews, addressing physiological phenomena, with 16 medical students in a problem-based curriculum. Four approaches--sifting, building, holding and moving--are outlined. The holding and moving approaches…

  20. Using the Theory of Planned Behavior to Understand the Beliefs of Chinese Teachers Concerning Teaching Games for Understanding

    Science.gov (United States)

    Wang, Lijuan

    2013-01-01

    This study describes the beliefs of Physical Education (PE) teachers regarding Teaching Games for Understanding (TGfU) based on the Theory of Planned Behavior (TPB). Twenty PE teachers participated in this study. Data collection consisted of a survey on demographic data and semistructured interviews. The research results indicate that the teachers…

  1. Genetic approaches to understanding human obesity.

    Science.gov (United States)

    Ramachandrappa, Shwetha; Farooqi, I Sadaf

    2011-06-01

    Obesity and its associated comorbidities represent one of the biggest public health challenges facing the world today. The heritability of body weight is high, and genetic variation plays a major role in determining the interindividual differences in susceptibility or resistance to the obesogenic environment. Here we discuss how genetic studies in humans have contributed to our understanding of the central pathways that govern energy homeostasis. We discuss how the arrival of technological advances such as next-generation sequencing will result in a major acceleration in the pace of gene discovery. The study of patients harboring these genetic variants has informed our understanding of the molecular and physiological pathways involved in energy homeostasis. We anticipate that future studies will provide the framework for the development of a more rational targeted approach to the prevention and treatment of genetically susceptible individuals.

  2. Understanding the Entrepreneurial Process: a Dynamic Approach

    Directory of Open Access Journals (Sweden)

    Vânia Maria Jorge Nassif

    2010-04-01

    Full Text Available There is considerable predominance in the adoption of perspectives based on characteristics in research into entrepreneurship. However, most studies describe the entrepreneur from a static or snapshot approach; very few adopt a dynamic perspective. The aim of this study is to contribute to the enhancement of knowledge concerning entrepreneurial process dynamics through an understanding of the values, characteristics and actions of the entrepreneur over time. By focusing on personal attributes, we have developed a framework that shows the importance of affective and cognitive aspects of entrepreneurs and the way that they evolve during the development of their business.

  3. An integrative approach to understanding bird origins.

    Science.gov (United States)

    Xu, Xing; Zhou, Zhonghe; Dudley, Robert; Mackem, Susan; Chuong, Cheng-Ming; Erickson, Gregory M; Varricchio, David J

    2014-12-12

    Recent discoveries of spectacular dinosaur fossils overwhelmingly support the hypothesis that birds are descended from maniraptoran theropod dinosaurs, and furthermore, demonstrate that distinctive bird characteristics such as feathers, flight, endothermic physiology, unique strategies for reproduction and growth, and a novel pulmonary system originated among Mesozoic terrestrial dinosaurs. The transition from ground-living to flight-capable theropod dinosaurs now probably represents one of the best-documented major evolutionary transitions in life history. Recent studies in developmental biology and other disciplines provide additional insights into how bird characteristics originated and evolved. The iconic features of extant birds for the most part evolved in a gradual and stepwise fashion throughout archosaur evolution. However, new data also highlight occasional bursts of morphological novelty at certain stages particularly close to the origin of birds and an unavoidable complex, mosaic evolutionary distribution of major bird characteristics on the theropod tree. Research into bird origins provides a premier example of how paleontological and neontological data can interact to reveal the complexity of major innovations, to answer key evolutionary questions, and to lead to new research directions. A better understanding of bird origins requires multifaceted and integrative approaches, yet fossils necessarily provide the final test of any evolutionary model. Copyright © 2014, American Association for the Advancement of Science.

  4. Teaching Games for Understanding Conference Supplement from the German Sport University

    Science.gov (United States)

    Research Quarterly for Exercise and Sport, 2016

    2016-01-01

    By bringing together the national German sports game community and an international scientific community in a joint conference, the 6th International Teaching Games for Understanding Conference (TGfU) Meets the 10th German Sports Games Symposium of the German Association of Sport Science (DVS), held July 25-27, 2016, at the German Sport University…

  5. An Institutional Approach to Understanding Energy Transitions

    Science.gov (United States)

    Koster, Auriane Magdalena

    Energy is a central concern of sustainability because how we produce and consume energy affects society, economy, and the environment. Sustainability scientists are interested in energy transitions away from fossil fuels because they are nonrenewable, increasingly expensive, have adverse health effects, and may be the main driver of climate change. They see an opportunity for developing countries to avoid the negative consequences fossil-fuel-based energy systems, and also to increase resilience, by leap-frogging-over the centralized energy grid systems that dominate the developed world. Energy transitions pose both challenges and opportunities. Obstacles to transitions include 1) an existing, centralized, complex energy-grid system, whose function is invisible to most users, 2) coordination and collective-action problems that are path dependent, and 3) difficulty in scaling up RE technologies. Because energy transitions rely on technological and social innovations, I am interested in how institutional factors can be leveraged to surmount these obstacles. The overarching question that underlies my research is: What constellation of institutional, biophysical, and social factors are essential for an energy transition? My objective is to derive a set of "design principles," that I term institutional drivers, for energy transitions analogous to Ostrom's institutional design principles. My dissertation research will analyze energy transitions using two approaches: applying the Institutional Analysis and Development Framework and a comparative case study analysis comprised of both primary and secondary sources. This dissertation includes: 1) an analysis of the world's energy portfolio; 2) a case study analysis of five countries; 3) a description of the institutional factors likely to promote a transition to renewable-energy use; and 4) an in-depth case study of Thailand's progress in replacing nonrenewable energy sources with renewable energy sources. My research will

  6. Systematic Approach to Better Understanding Integration Costs

    Energy Technology Data Exchange (ETDEWEB)

    Stark, Gregory B. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-09-01

    This research presents a systematic approach to evaluating the costs of integrating new generation and operational procedures into an existing power system, and the methodology is independent of the type of change or nature of the generation. The work was commissioned by the U.S. Department of Energy and performed by the National Renewable Energy Laboratory to investigate three integration cost-related questions: (1) How does the addition of new generation affect a system's operational costs, (2) How do generation mix and operating parameters and procedures affect costs, and (3) How does the amount of variable generation (non-dispatchable wind and solar) impact the accuracy of natural gas orders? A detailed operational analysis was performed for seven sets of experiments: variable generation, large conventional generation, generation mix, gas prices, fast-start generation, self-scheduling, and gas supply constraints. For each experiment, four components of integration costs were examined: cycling costs, non-cycling VO&M costs, fuel costs, and reserves provisioning costs. The investigation was conducted with PLEXOS production cost modeling software utilizing an updated version of the Institute of Electrical and Electronics Engineers 118-bus test system overlaid with projected operating loads from the Western Electricity Coordinating Council for the Sacramento Municipal Utility District, Puget Sound Energy, and Public Service Colorado in the year 2020. The test system was selected in consultation with an industry-based technical review committee to be a reasonable approximation of an interconnection yet small enough to allow the research team to investigate a large number of scenarios and sensitivity combinations. The research should prove useful to market designers, regulators, utilities, and others who want to better understand how system changes can affect production costs.

  7. A Hermeneutic Phenomenological Approach to understanding ...

    African Journals Online (AJOL)

    A dual philosophical approach is outlined: a phenomenological perspective apprehends stress-coping as an existential phenomenon, while the hermeneutic focus is on interpreting the links between lived experience and meaning. The kind of knowledge generated by means of this approach offers a new way of ...

  8. Understanding microelectronics a top-down approach

    CERN Document Server

    Maloberti, Franco

    2011-01-01

    The microelectronics evolution has given rise to many modern benefits but has also changed design methods and attitudes to learning. Technology advancements shifted focus from simple circuits to complex systems with major attention to high-level descriptions. The design methods moved from a bottom-up to a top-down approach. For today's students, the most beneficial approach to learning is this top-down method that demonstrates a global view of electronics before going into specifics. Franco Maloberti uses this approach to explain the fundamentals of electronics, such as processing functions,

  9. Understanding Successful Sandwich Placements: A Bourdieusian Approach

    Science.gov (United States)

    Clark, Martyn; Zukas, Miriam

    2016-01-01

    Sandwich placements and other integrated work and study schemes are increasingly advocated as a key means by which universities can promote students' employability. However, there is little understanding of how successful placements work in terms of facilitating learning and development. Drawing on three longitudinal case studies of students who…

  10. Theoretical approaches to natural language understanding

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    This book discusses the following: Computational Linguistics, Artificial Intelligence, Linguistics, Philosophy, and Cognitive Science and the current state of natural language understanding. Three topics form the focus for discussion; these topics include aspects of grammars, aspects of semantics/pragmatics, and knowledge representation.

  11. Genetic approaches to understanding human obesity

    OpenAIRE

    Ramachandrappa, Shwetha; Farooqi, I. Sadaf

    2011-01-01

    Obesity and its associated comorbidities represent one of the biggest public health challenges facing the world today. The heritability of body weight is high, and genetic variation plays a major role in determining the interindividual differences in susceptibility or resistance to the obesogenic environment. Here we discuss how genetic studies in humans have contributed to our understanding of the central ...

  12. Approaches for advancing scientific understanding of macrosystems

    Science.gov (United States)

    Levy, Ofir; Ball, Becky A.; Bond-Lamberty, Ben; Cheruvelil, Kendra S.; Finley, Andrew O.; Lottig, Noah R.; Surangi W. Punyasena,; Xiao, Jingfeng; Zhou, Jizhong; Buckley, Lauren B.; Filstrup, Christopher T.; Keitt, Tim H.; Kellner, James R.; Knapp, Alan K.; Richardson, Andrew D.; Tcheng, David; Toomey, Michael; Vargas, Rodrigo; Voordeckers, James W.; Wagner, Tyler; Williams, John W.

    2014-01-01

    The emergence of macrosystems ecology (MSE), which focuses on regional- to continental-scale ecological patterns and processes, builds upon a history of long-term and broad-scale studies in ecology. Scientists face the difficulty of integrating the many elements that make up macrosystems, which consist of hierarchical processes at interacting spatial and temporal scales. Researchers must also identify the most relevant scales and variables to be considered, the required data resources, and the appropriate study design to provide the proper inferences. The large volumes of multi-thematic data often associated with macrosystem studies typically require validation, standardization, and assimilation. Finally, analytical approaches need to describe how cross-scale and hierarchical dynamics and interactions relate to macroscale phenomena. Here, we elaborate on some key methodological challenges of MSE research and discuss existing and novel approaches to meet them.

  13. Understanding the adaptive approach to thermal comfort

    Energy Technology Data Exchange (ETDEWEB)

    Humphreys, M.A. [Oxford Univ. (United Kingdom). Centre for the Study of Christianity and Culture; Nicol, J.F. [Oxford Brookes Univ. (United Kingdom). School of Architecture

    1998-10-01

    This paper explains the adaptive approach to thermal comfort, and an adaptive model for thermal comfort is presented. The model is an example of a complex adaptive system (Casti 1996) whose equilibria are determined by the restrictions acting upon it. People`s adaptive actions are generally effective in securing comfort, which occurs at a wide variety of indoor temperatures. These comfort temperatures depend upon the circumstances in which people live, such as the climate and the heating or cooling regime. The temperatures may be estimated from the mean outdoor temperature and the availability of a heating or cooling plant. The evaluation of the parameters of the adaptive model requires cross-sectional surveys to establish current norms and sequential surveys (with and without intervention) to evaluate the rapidity of people`s adaptive actions. Standards for thermal comfort will need revision in the light of the adaptive approach. Implications of the adaptive model for the HVAC industry are noted.

  14. Oscillators - an approach for a better understanding

    DEFF Research Database (Denmark)

    Lindberg, Erik

    2003-01-01

    The aim of this tutorial is to provide an electronic engineer knowledge and insight for a better understanding of the mechanisms behind the behaviour of electronic oscillators. A linear oscillator is a mathematical fiction which can only be used as a starting point for the design of a real...... oscillator based on the Barkhausen criteria. Statements in textbooks and papers saying that the nonlinearities are bringing back the poles to the imaginary axis are wrong. The concept of "frozen eigenvalues" is introduced by means of piece-wise-linear modelling of the nonlinear components which are necessary...

  15. Understanding Nuclear Safety Culture: A Systemic Approach

    International Nuclear Information System (INIS)

    Afghan, A.N.

    2016-01-01

    The Fukushima accident was a systemic failure (Report by Director General IAEA on the Fukushima Daiichi Accident). Systemic failure is a failure at system level unlike the currently understood notion which regards it as the failure of component and equipment. Systemic failures are due to the interdependence, complexity and unpredictability within systems and that is why these systems are called complex adaptive systems (CAS), in which “attractors” play an important role. If we want to understand the systemic failures we need to understand CAS and the role of these attractors. The intent of this paper is to identify some typical attractors (including stakeholders) and their role within complex adaptive system. Attractors can be stakeholders, individuals, processes, rules and regulations, SOPs etc., towards which other agents and individuals are attracted. This paper will try to identify attractors in nuclear safety culture and influence of their assumptions on safety culture behavior by taking examples from nuclear industry in Pakistan. For example, if the nuclear regulator is an attractor within nuclear safety culture CAS then how basic assumptions of nuclear plant operators and shift in-charges about “regulator” affect their own safety behavior?

  16. Understanding bimolecular machines: Theoretical and experimental approaches

    Science.gov (United States)

    Goler, Adam Scott

    This dissertation concerns the study of two classes of molecular machines from a physical perspective: enzymes and membrane proteins. Though the functions of these classes of proteins are different, they each represent important test-beds from which new understanding can be developed by the application of different techniques. HIV1 Reverse Transcriptase is an enzyme that performs multiple functions, including reverse transcription of RNA into an RNA/DNA duplex, RNA degradation by the RNaseH domain, and synthesis of dsDNA. These functions allow for the incorporation of the retroviral genes into the host genome. Its catalytic cycle requires repeated large-scale conformational changes fundamental to its mechanism. Motivated by experimental work, these motions were studied theoretically by the application of normal mode analysis. It was observed that the lowest order modes correlate with largest amplitude (low-frequency) motion, which are most likely to be catalytically relevant. Comparisons between normal modes obtained via an elastic network model to those calculated from the essential dynamics of a series of all-atom molecular dynamics simulations show the self-consistency between these calculations. That similar conformational motions are seen between independent theoretical methods reinforces the importance of large-scale subdomain motion for the biochemical action of DNA polymerases in general. Moreover, it was observed that the major subunits of HIV1 Reverse Transcriptase interact quasi-harmonically. The 5HT3A Serotonin receptor and P2X1 receptor, by contrast, are trans-membrane proteins that function as ligand gated ion channels. Such proteins feature a central pore, which allows for the transit of ions necessary for cellular function across a membrane. The pore is opened by the ligation of binding sites on the extracellular portion of different protein subunits. In an attempt to resolve the individual subunits of these membrane proteins beyond the diffraction

  17. Cognitive neuroscience robotics B analytic approaches to human understanding

    CERN Document Server

    Ishiguro, Hiroshi; Asada, Minoru; Osaka, Mariko; Fujikado, Takashi

    2016-01-01

    Cognitive Neuroscience Robotics is the first introductory book on this new interdisciplinary area. This book consists of two volumes, the first of which, Synthetic Approaches to Human Understanding, advances human understanding from a robotics or engineering point of view. The second, Analytic Approaches to Human Understanding, addresses related subjects in cognitive science and neuroscience. These two volumes are intended to complement each other in order to more comprehensively investigate human cognitive functions, to develop human-friendly information and robot technology (IRT) systems, and to understand what kind of beings we humans are. Volume B describes to what extent cognitive science and neuroscience have revealed the underlying mechanism of human cognition, and investigates how development of neural engineering and advances in other disciplines could lead to deep understanding of human cognition.

  18. Cognitive neuroscience robotics A synthetic approaches to human understanding

    CERN Document Server

    Ishiguro, Hiroshi; Asada, Minoru; Osaka, Mariko; Fujikado, Takashi

    2016-01-01

    Cognitive Neuroscience Robotics is the first introductory book on this new interdisciplinary area. This book consists of two volumes, the first of which, Synthetic Approaches to Human Understanding, advances human understanding from a robotics or engineering point of view. The second, Analytic Approaches to Human Understanding, addresses related subjects in cognitive science and neuroscience. These two volumes are intended to complement each other in order to more comprehensively investigate human cognitive functions, to develop human-friendly information and robot technology (IRT) systems, and to understand what kind of beings we humans are. Volume A describes how human cognitive functions can be replicated in artificial systems such as robots, and investigates how artificial systems could acquire intelligent behaviors through interaction with others and their environment.

  19. Understanding the Coping Strategies of International Students: A Qualitative Approach

    Science.gov (United States)

    Khawaja, Nigar G.; Stallman, Helen M.

    2011-01-01

    International students encounter a range of additional challenges as a part of their tertiary study experience. A qualitative approach was used to understand the challenges faced by international students, coping strategies that promoted their personal resilience and advice they have for future international students. Twenty-two international…

  20. A narrative approach to understand students’ identities and choices

    DEFF Research Database (Denmark)

    Holmegaard, Henriette Tolstrup; Ulriksen, Lars; Madsen, Lene Møller

    2015-01-01

    of time. The applicability of the theory is discussed using empirical examples. The chapter argues that a narrative approach provides an understanding of choice of study as continuous processes where individuals work on their identities in terms of negotiating and constructing a coherent choice...

  1. Current Approaches to the Understanding of Early Infantile Autism.

    Science.gov (United States)

    Rickman, David L.

    This review of the literature provides summaries of the genetic, neurophysiological, and biochemical approaches to understanding autism, with special reference to neuroanatomic, cognitive, and neuropsychological studies of this disorder. Available instruments for the assessment of autism and various treatment alternatives including drug therapy,…

  2. Understanding Approaches for Managing Diversity in the Workplace

    DEFF Research Database (Denmark)

    Ravazzani, Silvia

    2016-01-01

    Purpose – This paper aims to enhance understanding of how companies actually implement diversity management, and of factors that may explain their approach. It does this by framing a tripartite model that articulates a combination of indicators, and by using this model to investigate the prevalent...... approach for managing diversity in Italy and the contingent factors at play. Design/methodology/approach – The paper presents data from a survey conducted among 90 Italian companies, and two focus groups consisting of experts and managers. Findings – The most common approach among Italian companies...... in Italy, where interest in diversity is growing due to the increased participation of women and immigrants in the labor market and the initiatives inspired by the EU and multinational companies. In addition, the research model used in this study integrates existing typologies of diversity management...

  3. Understanding high-level radwaste disposal through the historical approach

    International Nuclear Information System (INIS)

    Cramer, E.N.

    1993-01-01

    As an example of different needs in communication to persons other than physical scientists, a teacher needs an approach somewhere between just assigning to an advanced student the book Understanding Radioactive Waste to review and administering to a science class the several-week module open-quotes Science, Society and America's Nuclear Waste.close quotes When a nuclear professional reviews for the class the lengthy US research and development (R ampersand D) program, a broader approach is provided that can focus on geology or management aspects or can be made suitable for middle and elementary schools' earth or environmental science studies

  4. Understanding complex urban systems multidisciplinary approaches to modeling

    CERN Document Server

    Gurr, Jens; Schmidt, J

    2014-01-01

    Understanding Complex Urban Systems takes as its point of departure the insight that the challenges of global urbanization and the complexity of urban systems cannot be understood – let alone ‘managed’ – by sectoral and disciplinary approaches alone. But while there has recently been significant progress in broadening and refining the methodologies for the quantitative modeling of complex urban systems, in deepening the theoretical understanding of cities as complex systems, or in illuminating the implications for urban planning, there is still a lack of well-founded conceptual thinking on the methodological foundations and the strategies of modeling urban complexity across the disciplines. Bringing together experts from the fields of urban and spatial planning, ecology, urban geography, real estate analysis, organizational cybernetics, stochastic optimization, and literary studies, as well as specialists in various systems approaches and in transdisciplinary methodologies of urban analysis, the volum...

  5. A diagnostic approach to understanding entrepreneurship in health care.

    Science.gov (United States)

    McCleary, Karl J; Rivers, Patrick A; Schneller, Eugene S

    2006-01-01

    Health care is quite different from other industries because of its organizational structure, service delivery, and financing of health services. Balancing costs, quality, and access presents unique challenges for each stakeholder group committed to promoting the health and healing of its citizens. Using the diagnostic approach to health care entrepreneurship, we created a framework from research in the field to understand the predisposing, enabling, and reinforcing factors most relevant to successful entrepreneurship.

  6. Understanding Plant Nitrogen Metabolism through Metabolomics and Computational Approaches

    Directory of Open Access Journals (Sweden)

    Perrin H. Beatty

    2016-10-01

    Full Text Available A comprehensive understanding of plant metabolism could provide a direct mechanism for improving nitrogen use efficiency (NUE in crops. One of the major barriers to achieving this outcome is our poor understanding of the complex metabolic networks, physiological factors, and signaling mechanisms that affect NUE in agricultural settings. However, an exciting collection of computational and experimental approaches has begun to elucidate whole-plant nitrogen usage and provides an avenue for connecting nitrogen-related phenotypes to genes. Herein, we describe how metabolomics, computational models of metabolism, and flux balance analysis have been harnessed to advance our understanding of plant nitrogen metabolism. We introduce a model describing the complex flow of nitrogen through crops in a real-world agricultural setting and describe how experimental metabolomics data, such as isotope labeling rates and analyses of nutrient uptake, can be used to refine these models. In summary, the metabolomics/computational approach offers an exciting mechanism for understanding NUE that may ultimately lead to more effective crop management and engineered plants with higher yields.

  7. Network Analysis: A Novel Approach to Understand Suicidal Behaviour

    Directory of Open Access Journals (Sweden)

    Derek de Beurs

    2017-02-01

    Full Text Available Although suicide is a major public health issue worldwide, we understand little of the onset and development of suicidal behaviour. Suicidal behaviour is argued to be the end result of the complex interaction between psychological, social and biological factors. Epidemiological studies resulted in a range of risk factors for suicidal behaviour, but we do not yet understand how their interaction increases the risk for suicidal behaviour. A new approach called network analysis can help us better understand this process as it allows us to visualize and quantify the complex association between many different symptoms or risk factors. A network analysis of data containing information on suicidal patients can help us understand how risk factors interact and how their interaction is related to suicidal thoughts and behaviour. A network perspective has been successfully applied to the field of depression and psychosis, but not yet to the field of suicidology. In this theoretical article, I will introduce the concept of network analysis to the field of suicide prevention, and offer directions for future applications and studies.

  8. Understanding the organization of cognitive approaches to translation

    DEFF Research Database (Denmark)

    Serban, Maria

    2017-01-01

    Cognitive approaches to translation studies are driven by three interrelated aims: to understand the structure and organization of the capacities of cognitive agents involved in processes of translation, to build better theories and models of translation, and to develop more efficient methods...... theory, it is more descriptively adequate and more fruitful to understand it as a family of projects based on multiple theories that are relevant for studying different aspects of the translation process. This perspective allows us to extract the erotetic structure of these programs which are organized...... underpinnings of translation is both varied and constantly developing. This essay showcases some current research programs that reflect the fruitfulness of the interdisciplinary structure of translation studies. Instead of thinking about cognitive research on translation as being driven by a master cognitive...

  9. A Dual Process Approach to Understand Tourists’ Destination Choice Processes

    DEFF Research Database (Denmark)

    Kock, Florian; Josiassen, Alexander; Assaf, Albert

    2017-01-01

    Most studies that investigate tourists' choices of destinations apply the concept of mental destination representations, also referred to as destination image. The present study investigates tourists’ destination choice processes by conceptualizing how different components of destination image...... are mentally processed in tourists' minds. Specifically, the seminal dual processing approach is applied to the destination image literature. By doing this, we argue that some components of mental destination representations are processed systematically while others serve as inputs for heuristics...... that individuals apply to inform their decision making. Understanding how individuals make use of their mental destination representations and how they color their decision-making is essential in order to better explain tourist behavior....

  10. Understanding electron magnetic circular dichroism in a transition potential approach

    Science.gov (United States)

    Barthel, J.; Mayer, J.; Rusz, J.; Ho, P.-L.; Zhong, X. Y.; Lentzen, M.; Dunin-Borkowski, R. E.; Urban, K. W.; Brown, H. G.; Findlay, S. D.; Allen, L. J.

    2018-04-01

    This paper introduces an approach based on transition potentials for inelastic scattering to understand the underlying physics of electron magnetic circular dichroism (EMCD). The transition potentials are sufficiently localized to permit atomic-scale EMCD. Two-beam and three-beam systematic row cases are discussed in detail in terms of transition potentials for conventional transmission electron microscopy, and the basic symmetries which arise in the three-beam case are confirmed experimentally. Atomic-scale EMCD in scanning transmission electron microscopy (STEM), using both a standard STEM probe and vortex beams, is discussed.

  11. Developing An Analytic Approach to Understanding the Patient Care Experience

    Science.gov (United States)

    Springman, Mary Kate; Bermeo, Yalissa; Limper, Heather M

    2016-01-01

    The amount of data available to health-care institutions regarding the patient care experience has grown tremendously. Purposeful approaches to condensing, interpreting, and disseminating these data are becoming necessary to further understand how clinical and operational constructs relate to patient satisfaction with their care, identify areas for improvement, and accurately measure the impact of initiatives designed to improve the patient experience. We set out to develop an analytic reporting tool deeply rooted in the patient voice that would compile patient experience data obtained throughout the medical center. PMID:28725852

  12. Genetic approaches to understanding post-traumatic stress disorder

    Science.gov (United States)

    Almli, Lynn M.; Fani, Negar; Smith, Alicia K.; Ressler, Kerry J.

    2015-01-01

    Post-traumatic stress disorder (PTSD) is increasingly recognized as both a disorder of enormous mental health and societal burden, but also as an anxiety disorder that may be particularly understandable from a scientific perspective. Specifically, PTSD can be conceptualized as a disorder of fear and stress dysregulation, and the neural circuitry underlying these pathways in both animals and humans are becoming increasingly well understood. Furthermore, PTSD is the only disorder in psychiatry in which the initiating factor, the trauma exposure, can be identified. Thus, the pathophysiology of the fear and stress response underlying PTSD can be examined and potentially interrupted. Twin studies have shown that the development of PTSD following a trauma is heritable, and that genetic risk factors may account for up to 30–40% of this heritability. A current goal is to understand the gene pathways that are associated with PTSD, and how those genes act on the fear/stress circuitry to mediate risk vs. resilience for PTSD. This review will examine gene pathways that have recently been analysed, primarily through candidate gene studies (including neuroimaging studies of candidate genes), in addition to genome-wide associations and the epigenetic regulation of PTSD. Future and on-going studies are utilizing larger and collaborative cohorts to identify novel gene candidates through genome-wide association and other powerful genomic approaches. Identification of PTSD biological pathways strengthens the hope of progress in the mechanistic understanding of a model psychiatric disorder and allows for the development of targeted treatments and interventions. PMID:24103155

  13. Genetic approaches to understanding post-traumatic stress disorder.

    Science.gov (United States)

    Almli, Lynn M; Fani, Negar; Smith, Alicia K; Ressler, Kerry J

    2014-02-01

    Post-traumatic stress disorder (PTSD) is increasingly recognized as both a disorder of enormous mental health and societal burden, but also as an anxiety disorder that may be particularly understandable from a scientific perspective. Specifically, PTSD can be conceptualized as a disorder of fear and stress dysregulation, and the neural circuitry underlying these pathways in both animals and humans are becoming increasingly well understood. Furthermore, PTSD is the only disorder in psychiatry in which the initiating factor, the trauma exposure, can be identified. Thus, the pathophysiology of the fear and stress response underlying PTSD can be examined and potentially interrupted. Twin studies have shown that the development of PTSD following a trauma is heritable, and that genetic risk factors may account for up to 30-40% of this heritability. A current goal is to understand the gene pathways that are associated with PTSD, and how those genes act on the fear/stress circuitry to mediate risk vs. resilience for PTSD. This review will examine gene pathways that have recently been analysed, primarily through candidate gene studies (including neuroimaging studies of candidate genes), in addition to genome-wide associations and the epigenetic regulation of PTSD. Future and on-going studies are utilizing larger and collaborative cohorts to identify novel gene candidates through genome-wide association and other powerful genomic approaches. Identification of PTSD biological pathways strengthens the hope of progress in the mechanistic understanding of a model psychiatric disorder and allows for the development of targeted treatments and interventions.

  14. Understanding human metabolic physiology: a genome-to-systems approach.

    Science.gov (United States)

    Mo, Monica L; Palsson, Bernhard Ø

    2009-01-01

    The intricate nature of human physiology renders its study a difficult undertaking, and a systems biology approach is necessary to understand the complex interactions involved. Network reconstruction is a key step in systems biology and represents a common denominator because all systems biology research on a target organism relies on such a representation. With the recent development of genome-scale human metabolic networks, metabolic systems analysis is now possible and has initiated a shift towards human systems biology. Here, we review the important aspects of reconstructing a bottom-up human metabolic network, the network's role in modeling human physiology and the necessity for a community-based consensus reconstruction of human metabolism to be established.

  15. [Understanding unsuccessful attempts to quit smoking: a social phenomenology approach].

    Science.gov (United States)

    Jesus, Maria Cristina Pinto de; Silva, Marcelo Henrique da; Cordeiro, Samara Macedo; Kortchmar, Estela; Zampier, Vanderleia Soeli de Barros; Merighi, Miriam Aparecida Barbosa

    2016-02-01

    The aim of this paper is to understand the experience of smokers in view of unsuccessful attempts to quit smoking. This study is based on social phenomenology. Between November and December of 2014, nine interviews were conducted with people that had attempted to quit smoking. The content of these interviews was analyzed and discussed based on the related literature. Unsuccessful attempts to quit smoking are related to tobacco addiction; cigarettes are seen as a support to cope with everyday stressful situations. Attempts to quit the smoking habits were based on the need of health improvement and insistence of family and friends. Smokers reported the use of habit cessation strategies learned in support groups, but they also express expectation of specialized psychological support. The study points out the need to expand the strategies of approaching smokers, and reinforcing psychological support in order to achieve success in the attempt to quit smoking.

  16. NRC says integrated approach needed to understand, protect environment

    Science.gov (United States)

    Kolb, Charles E.; Loehr, Raymond C.; Gopnik, Morgan

    A recent study by the National Research Council (NRC) advocates a more comprehensive and integrated approach to our nation's environmental research and development (R&D) activities. Because we face environmental problems of unprecedented complexity, the study maintains that the traditional practice of studying isolated environmental problems and devising narrowly focused control or remediation strategies to manage them will no longer suffice.In the report, Building a Foundation for Sound Environmental Decisions [National Academy Press, 1997], an NRC committee highlighted the need for developing a deeper scientific understanding of ecosystems, as well as the sociological and economic aspects of human interactions with the environment. To achieve these goals, the committee recommended a core research agenda for the Environmental Protection Agency (EPA) that has three components.

  17. Understanding Anaplasmataceae pathogenesis using ‘Omics’ approaches

    Directory of Open Access Journals (Sweden)

    Ludovic ePruneau

    2014-07-01

    Full Text Available This paper examines how Omics approaches improve our understanding of Anaplasmataceae pathogenesis, through a global and integrative strategy to identify genes and proteins involved in biochemical pathways key for pathogen-host-vector interactions.The Anaplasmataceae family comprises obligate intracellular bacteria mainly transmitted by arthropods. These bacteria are responsible for major human and animal endemic and emerging infectious diseases with important economic and public health impacts. In order to improve disease control strategies, it is essential to better understand their pathogenesis. Our work focused on four Anaplasmataceae, which cause important animal, human and zoonotic diseases: Anaplasma marginale, A. phagocytophilum, Ehrlichia chaffeensis and E. ruminantium. Wolbachia spp. an endosymbiont of arthropods was also included in this review as a model of a non-pathogenic Anaplasmataceae.A gap analysis on Omics approaches on Anaplasmataceae was performed, which highlighted a lack of studies on the genes and proteins involved in the infection of hosts and vectors. Furthermore, most of the studies have been done on the pathogen itself, mainly on infectious free-living forms and rarely on intracellular forms. In order to perform a transcriptomic analysis of the intracellular stage of development, researchers developed methods to enrich bacterial transcripts from infected cells. These methods are described in this paper. Bacterial genes encoding outer membrane proteins, post-translational modifications, eukaryotic repeated motif proteins, proteins involved in osmotic and oxidative stress and hypothetical proteins have been identified to play a key role in Anaplasmataceae pathogenesis. Further investigations on the function of these outer membrane proteins and hypothetical proteins will be essential to confirm their role in the pathogenesis. Our work underlines the need for further studies in this domain and on host and vector responses

  18. Quantifying space, understanding minds: A visual summary approach

    Directory of Open Access Journals (Sweden)

    Mark Simpson

    2017-06-01

    Full Text Available This paper presents an illustrated, validated taxonomy of research that compares spatial measures to human behavior. Spatial measures quantify the spatial characteristics of environments, such as the centrality of intersections in a street network or the accessibility of a room in a building from all the other rooms. While spatial measures have been of interest to spatial sciences, they are also of importance in the behavioral sciences for use in modeling human behavior. A high correlation between values for spatial measures and specific behaviors can provide insights into an environment's legibility, and contribute to a deeper understanding of human spatial cognition. Research in this area takes place in several domains, which makes a full understanding of existing literature difficult. To address this challenge, we adopt a visual summary approach. Literature is analyzed, and recurring topics are identified and validated with independent inter-rater agreement tasks in order to create a robust taxonomy for spatial measures and human behavior. The taxonomy is then illustrated with a visual representation that allows for at-a-glance visual access to the content of individual research papers in a corpus. A public web interface has been created that allows interested researchers to add to the database and create visual summaries for their research papers using our taxonomy.

  19. Teacher engagement with teaching games for understanding - game sense in physical education

    Directory of Open Access Journals (Sweden)

    SHANE PILL

    2011-06-01

    Full Text Available Previous research has suggested that the implementation of innovation that reinvigorates the teaching ofgames and sports in Australian schools has faced considerable barriers (Alexander, 2008; Light & Georgakis,2005; Pill, 2009. One example of an innovation to enhance sport teaching and learning is Teaching Games forUnderstanding-Game Sense (den Dun, 1996, 1997a. This paper presents the findings from a survey of physicaleducation teachers’ in one Australian state and the degree of engagement with TGfU-GS curriculum design andenactment. Sixty Four teachers participated in a web survey investigating the penetration of TGfU-GScurriculum. The data was treated as qualitative and the surveys were analysed by comparative systematicinterpretation to reveal recurring themes. The analysis indicated that TGfU- GS was thought to be mostapplicable for senior years (Years 11-12 physical education. Teachers recognised the use of small-sidedmodified games and ‘questioning as pedagogy’ as common practice and not distinctive to a TGfU-GS approach.However, the use of questioning was generally not planned for in teacher lesson preparation and lesson planningdid not utilise TGfU-GS game categories to thematically develop game understanding systematically acrosssport specific units of work. While elements of TGfU-GS pedagogy are evidenced in the design and enactmentof sport and sport related games teachers TGfU-GS was yet to be fully understood and implemented by themajority of teachers.

  20. A vascular mechanistic approach to understanding Raynaud phenomenon.

    Science.gov (United States)

    Flavahan, Nicholas A

    2015-03-01

    During exposure to cold, our bodies attempt to maintain normal core temperature by restricting heat loss through cutaneous vasoconstriction, and by increasing heat production through shivering and nonshivering thermogenesis. In selected areas of human skin (including on the fingers and toes), the vascular system has specialized structural and functional features that enable it to contribute to thermoregulation. These features include arteriovenous anastomoses, which directly connect the arterial and venous systems and bypass the nutritional capillaries supplying blood to the skin tissue. Of note, Raynaud phenomenon predominantly affects the arterial territories supplying these specialized areas of skin. Indeed, Raynaud phenomenon can be considered a disorder of vascular thermoregulatory control. This Review presents an understanding of Raynaud phenomenon in the context of vascular and thermoregulatory control mechanisms, including the role of unique thermosensitive vascular structural and functional specialization, and describes the potential role of thermogenesis in this disorder. This new approach provides remarkable insight into the disease process and builds a framework to critically appraise the existing knowledge base. This paradigm also explains the deficiencies in some current therapeutic approaches, and highlights new areas of potential relevance to the pathogenesis and treatment of Raynaud phenomenon that should be expanded and explored.

  1. Understanding Aquatic Rhizosphere Processes Through Metabolomics and Metagenomics Approach

    Science.gov (United States)

    Lee, Yong Jian; Mynampati, Kalyan; Drautz, Daniela; Arumugam, Krithika; Williams, Rohan; Schuster, Stephan; Kjelleberg, Staffan; Swarup, Sanjay

    2013-04-01

    The aquatic rhizosphere is a region around the roots of aquatic plants. Many studies focusing on terrestrial rhizosphere have led to a good understanding of the interactions between the roots, its exudates and its associated rhizobacteria. The rhizosphere of free-floating roots, however, is a different habitat that poses several additional challenges, including rapid diffusion rates of signals and nutrient molecules, which are further influenced by the hydrodynamic forces. These can lead to rapid diffusion and complicates the studying of diffusible factors from both plant and/or rhizobacterial origins. These plant systems are being increasingly used for self purification of water bodies to provide sustainable solution. A better understanding of these processes will help in improving their performance for ecological engineering of freshwater systems. The same principles can also be used to improve the yield of hydroponic cultures. Novel toolsets and approaches are needed to investigate the processes occurring in the aquatic rhizosphere. We are interested in understanding the interaction between root exudates and the complex microbial communities that are associated with the roots, using a systems biology approach involving metabolomics and metagenomics. With this aim, we have developed a RhizoFlowCell (RFC) system that provides a controlled study of aquatic plants, observed the root biofilms, collect root exudates and subject the rhizosphere system to changes in various chemical or physical perturbations. As proof of concept, we have used RFC to test the response of root exudation patterns of Pandanus amaryllifolius after exposure to the pollutant naphthalene. Complexity of root exudates in the aquatic rhizosphere was captured using this device and analysed using LC-qTOF-MS. The highly complex metabolomic profile allowed us to study the dynamics of the response of roots to varying levels of naphthalene. The metabolic profile changed within 5mins after spiking with

  2. Some approaches to understanding public perceptions of risk

    International Nuclear Information System (INIS)

    Greer-Wootten, B.

    1981-01-01

    The debate on nuclear power contains a central set of arguments that can be related, by and large, to differences in the meaning of risk assessment for various concerned publics. At an earlier point in time the arguments largely concerned power production (reactor safety), but now most components of the nuclear fuel cycle are subject to risk perceptions. The strongest levels of public concern over time have focussed on waste management, and in this area illustrates most clearly the gaps between the assessments of the technical community and those of the publics. In order to understand such gaps, a theoretical framework is necessary. The broadest scope for such a framework is found in the I.I.A.S.A. - I.A.E.A. model developed by H.J. Otway, with its three interrelated components of risk estimation (technical), risk evaluation (public) and risk management. The model is described in this paper, as well as a number of empirical studies that derive from it and attempt to measure public perceptions of risks. These studies are then compared to several alternative explanations: the use of public opinion surveys; risk rating tasks based on psychologicl theory; the structure of arguments used by members of the public in qualitative focus group discussions; and a model of local community conflict derived from the content analysis of newspapers. Throughout the discussion, examples are taken wherever possible, from recent Canadian studies, in which the effects of major incidents (such as T.M.I., the Mississauga derailment, the Blind River refinery siting controversy, etc.) become apparent. It is suggested that our understanding of public perceptions of risks cannot be divorced from the set of broad societal concerns evidenced in the I.I.A.S.A. - I.A.E.A. model, and that the crucial elements of this approach are seen in its emphasis on the decision-making process

  3. Measuring and understanding soil water repellency through novel interdisciplinary approaches

    Science.gov (United States)

    Balshaw, Helen; Douglas, Peter; Doerr, Stefan; Davies, Matthew

    2017-04-01

    Food security and production is one of the key global issues faced by society. It has become evermore essential to work the land efficiently, through better soil management and agronomy whilst protecting the environment from air and water pollution. The failure of soil to absorb water - soil water repellency - can lead to major environmental problems such as increased overland flow and soil erosion, poor uptake of agricultural chemicals and increased risk of groundwater pollution due to the rapid transfer of contaminants and nutrient leaching through uneven wetting and preferential flow pathways. Understanding the causes of soil hydrophobicity is essential for the development of effective methods for its amelioration, supporting environmental stability and food security. Organic compounds deposited on soil mineral or aggregate surfaces have long been recognised as a major factor in causing soil water repellency. It is widely accepted that the main groups of compounds responsible are long-chain acids, alkanes and other organic compounds with hydrophobic properties. However, when reapplied to sands and soils, the degree of water repellency induced by these compounds and mixtures varied widely with compound type, amount and mixture, in a seemingly unpredictable way. Our research to date involves two new approaches for studying soil wetting. 1) We challenge the theoretical basis of current ideas on the measured water/soil contact angle measurements. Much past and current discussion involves Wenzel and Cassie-Baxter models to explain anomalously high contact angles for organics on soils, however here we propose that these anomalously high measured contact angles are a consequence of the measurement of a water drop on an irregular non-planar surface rather than the thermodynamic factors of the Cassie-Baxter and Wenzel models. In our analysis we have successfully used a much simpler geometric approach for non-flat surfaces such as soil. 2) Fluorescent and phosphorescent

  4. Molecular Approaches to Understanding C & N Dynamics in MArine Sediments

    Energy Technology Data Exchange (ETDEWEB)

    Arturo Massol; James Tiedje; Jizhong Zhou; Allan Devol

    2007-05-16

    Continental margin sediments constitute only about 10% of the total sediment surface area in the world’s oceans, nevertheless they are the dominant sites of nitrogen (N) cycling. Recent studies suggest that the oceanic nitrogen budget is unbalanced, primarily due to a higher nitrogen removal rate in contrast to the fixation rate, and it has been suggested that denitrification activity contributes significantly to this imbalance. Although denitrification in marine environments has been studied intensively at the process level, little is known about the species abundance, composition, distribution, and functional differences of the denitrifying population. Understanding the diversity of microbial populations in marine environments, their responses to various environmental factors such as NO3-, and how this impact the rate of denitrification is critical to predict global N dynamics. Environmental Microbiology has the prompt to study the influence of each microbial population on a biogeochemical process within a given ecosystem. Culture-dependent and –independent techniques using nucleic acid probes can access the identity and activity of cultured and uncultured microorganisms. Nucleic acid probes can target distintict genes which set phylogenetic relationships, such as rDNA 16S, DNA gyrase (gyrB) and RNA polymerase sigma 70 factor (rpoD). In the other hand, the genetic capabilities and their expression could be tracked using probes that target several functional genes, such as nirS, nirK, nosZ, and nifH, which are genes involved in denitrification. Selective detection of cells actively expressing functional genes within a community using In Situ Reverse Transcription-PCR (ISRT-PCR) could become a powerful culture-independent technique in microbial ecology. Here we describe an approach to study the expression of nirS genes in denitrifying bacteria. Pure cultures of Pseudomonas stutzeri and Paracoccus denitrificans, as well as co-cultures with non

  5. Understanding Fatty Acid Metabolism through an Active Learning Approach

    Science.gov (United States)

    Fardilha, M.; Schrader, M.; da Cruz e Silva, O. A. B.; da Cruz e Silva, E. F.

    2010-01-01

    A multi-method active learning approach (MALA) was implemented in the Medical Biochemistry teaching unit of the Biomedical Sciences degree at the University of Aveiro, using problem-based learning as the main learning approach. In this type of learning strategy, students are involved beyond the mere exercise of being taught by listening. Less…

  6. [Bone Cell Biology Assessed by Microscopic Approach. A mathematical approach to understand bone remodeling].

    Science.gov (United States)

    Kameo, Yoshitaka; Adachi, Taiji

    2015-10-01

    It is well known that bone tissue can change its outer shape and internal structure by remodeling according to a changing mechanical environment. However, the mechanism of bone functional adaptation induced by the collaborative metabolic activities of bone cells in response to mechanical stimuli remains elusive. In this article, we focus on the hierarchy of bone structure and function from the microscopic cellular level to the macroscopic tissue level. We provide an overview of a mathematical approach to understand the adaptive changes in trabecular morphology under the application of mechanical stress.

  7. Public understanding of hydrogen energy: A theoretical approach

    International Nuclear Information System (INIS)

    Sherry-Brennan, Fionnguala; Devine-Wright, Hannah; Devine-Wright, Patrick

    2010-01-01

    The aim of this paper was to investigate public understanding of hydrogen energy using a particular social-psychological theory, namely, the theory of social representations to explore how processes of understanding generated lay knowledge of hydrogen energy. Using a free association method for data collection and multidimensional scaling for analysis, the results enabled the identification of themes in the data such as energy, environment, community, science, and technology, and people and place, around which understanding was based. Processes of representation, such as anchoring to pre-existing knowledge, were seen as essential in guiding understanding. The results indicated that there were diverse influences involved in understanding and, although risk perception of hydrogen was acknowledged, community concerns were seen to override any negative effect of focussing on risk. The role of emotion in decision-making was highlighted as positive emotional responses to the Promoting Unst's Renewable Energy (PURE), a local hydrogen storage project, resulted in hydrogen energy generally being positively evaluated despite acknowledged risks posed by hydrogen such as its explosiveness and flammability. Recommendations for policy include recognising that the combination of expert and lay knowledge plays an important role in public acceptance or rejection of hydrogen energy.

  8. Public understanding of hydrogen energy. A theoretical approach

    Energy Technology Data Exchange (ETDEWEB)

    Sherry-Brennan, Fionnguala; Devine-Wright, Hannah; Devine-Wright, Patrick [Manchester Architecture Research Centre (MARC), University of Manchester, Humanities Bridgeford Street, Oxford Road, Manchester M13 9PL (United Kingdom)

    2010-10-15

    The aim of this paper was to investigate public understanding of hydrogen energy using a particular social-psychological theory, namely, the theory of social representations to explore how processes of understanding generated lay knowledge of hydrogen energy. Using a free association method for data collection and multidimensional scaling for analysis, the results enabled the identification of themes in the data such as energy, environment, community, science, and technology, and people and place, around which understanding was based. Processes of representation, such as anchoring to pre-existing knowledge, were seen as essential in guiding understanding. The results indicated that there were diverse influences involved in understanding and, although risk perception of hydrogen was acknowledged, community concerns were seen to override any negative effect of focussing on risk. The role of emotion in decision-making was highlighted as positive emotional responses to the Promoting Unst's Renewable Energy (PURE), a local hydrogen storage project, resulted in hydrogen energy generally being positively evaluated despite acknowledged risks posed by hydrogen such as its explosiveness and flammability. Recommendations for policy include recognising that the combination of expert and lay knowledge plays an important role in public acceptance or rejection of hydrogen energy. (author)

  9. Public understanding of hydrogen energy: A theoretical approach

    Energy Technology Data Exchange (ETDEWEB)

    Sherry-Brennan, Fionnguala, E-mail: fionnguala@manchester.ac.u [Manchester Architecture Research Centre (MARC), University of Manchester, Humanities Bridgeford Street, Oxford Road, Manchester M13 9PL (United Kingdom); Devine-Wright, Hannah; Devine-Wright, Patrick [Manchester Architecture Research Centre (MARC), University of Manchester, Humanities Bridgeford Street, Oxford Road, Manchester M13 9PL (United Kingdom)

    2010-10-15

    The aim of this paper was to investigate public understanding of hydrogen energy using a particular social-psychological theory, namely, the theory of social representations to explore how processes of understanding generated lay knowledge of hydrogen energy. Using a free association method for data collection and multidimensional scaling for analysis, the results enabled the identification of themes in the data such as energy, environment, community, science, and technology, and people and place, around which understanding was based. Processes of representation, such as anchoring to pre-existing knowledge, were seen as essential in guiding understanding. The results indicated that there were diverse influences involved in understanding and, although risk perception of hydrogen was acknowledged, community concerns were seen to override any negative effect of focussing on risk. The role of emotion in decision-making was highlighted as positive emotional responses to the Promoting Unst's Renewable Energy (PURE), a local hydrogen storage project, resulted in hydrogen energy generally being positively evaluated despite acknowledged risks posed by hydrogen such as its explosiveness and flammability. Recommendations for policy include recognising that the combination of expert and lay knowledge plays an important role in public acceptance or rejection of hydrogen energy.

  10. The Use of Evolutionary Approaches to Understand Single Cell Genomes

    Directory of Open Access Journals (Sweden)

    Haiwei eLuo

    2015-03-01

    Full Text Available The vast majority of environmental bacteria and archaea remain uncultivated, yet their genome sequences are rapidly becoming available through single cell sequencing technologies. Reconstructing metabolism is one common way to make use of genome sequences of ecologically important bacteria, but molecular evolutionary analysis is another approach that, while currently underused, can reveal important insights into the function of these uncultivated microbes in nature. Because genome sequences from single cells are often incomplete, metabolic reconstruction based on genome content can be compromised. However, this problem does not necessarily impede the use of phylogenomic and population genomic approaches that are based on patterns of polymorphisms and substitutions at nucleotide and amino acid sites. These approaches explore how various evolutionary forces act to assemble genetic diversity within and between lineages. In this mini-review, I present examples illustrating the benefits of analyzing single cell genomes using evolutionary approaches.

  11. Understanding Online Non-Native English Speakers: An Acculturation Approach

    Science.gov (United States)

    Chou, Pao-Nan; Chen, Wei-Fan

    2009-01-01

    The number of international students who take online courses in the U.S. is growing, and consequently a need exists to understand how these online minority groups learn in Western-designed online educational settings. This article proposes applying a concept of acculturation into online teaching practice to allow examination of international…

  12. Understanding PRACTICE: An Acronym for the Holistic Approach to Practice

    Science.gov (United States)

    Townsend, Brendan

    2012-01-01

    The purpose of this article is to provide a mnemonic device that when incorporated into practice behavior is shown through case study to help students develop an understanding of the relationship between exercises, new and old, and the music that they are preparing. I developed the mnemonic "Preparation of Relevant Activities Causes Technical…

  13. Understanding decision making in teachers’ curriculum design approaches

    NARCIS (Netherlands)

    Boschman, F.B.; McKenney, Susan; Voogt, Joke

    2014-01-01

    The goal of this study was to reach a better understanding of the intuitive decisions teachers make when designing a technology-rich learning environment. A multiple case-study design was employed to examine what kinds of factors (external priorities, existing orientations or practical concerns)

  14. Understanding decision making in teachers’ curriculum design approaches

    NARCIS (Netherlands)

    Boschman, Ferry; McKenney, Susan; Voogt, Joke

    2015-01-01

    The goal of this study was to reach a better understanding of the intuitive decisions teachers make when designing a technology-rich learning environment. A multiple case-study design was employed to examine what kinds of factors (external priorities, existing orientations or practical concerns)

  15. Understanding decision making in teachers' curriculum design approaches

    NARCIS (Netherlands)

    Boschman, F.; McKenney, S.; Voogt, J.M.

    2014-01-01

    The goal of this study was to reach a better understanding of the intuitive decisions teachers make when designing a technology-rich learning environment. A multiple case-study design was employed to examine what kinds of factors (external priorities, existing orientations or practical concerns)

  16. from concept to understanding: a new approach to terminography in ...

    African Journals Online (AJOL)

    kaans remains predominantly the lan- guage of the public service. But a very small volume of official communication take place by way of Zulu or Xhosa. Although the present and previous governments in the. RSA have taken .... not understand 'logistics' but he has no clue whatsoever concerning the elements comprising.

  17. Understanding Enhanced Recovery After Surgery Guidelines: An Introductory Approach.

    Science.gov (United States)

    Elias, Kevin M

    2017-09-01

    Enhanced Recovery After Surgery (ERAS ® ) is a multimodal, multidisciplinary approach to surgical care. The ERAS Society has issued recommendations for many surgical procedures that address best practices in preoperative, intraoperative, and postoperative management. When implementing a new ERAS protocol, the length and detail of the recommendations can be overwhelming. In this study, the general principles of the ERAS guidelines are summarized and workload is distributed among the different members of the care team. This compartmentalized approach provides an easier way to involve key personnel in the ERAS process and assigns a role for everyone in making ERAS a success.

  18. A neural network approach to MR and CT image understanding

    International Nuclear Information System (INIS)

    Caramella, D.; Poli, R.; Rucci, M.; Valli, G.

    1992-01-01

    The problems usually faced in the development of automatic systems for MR and CT image analysis are briefly discussed. Afterward, an approach based on the integration of artificial neural networks and computer vision techniques which should be capable of overcoming the encountered difficulties is described. According to this approach, a system for the construction of 3D descriptions of the organs as imaged by MR or CT slice sequences has been developed. The architecture and preliminary results of this system are reported. (orig.) [de

  19. Understanding visualization: a formal approach using category theory and semiotics.

    Science.gov (United States)

    Vickers, Paul; Faith, Joe; Rossiter, Nick

    2013-06-01

    This paper combines the vocabulary of semiotics and category theory to provide a formal analysis of visualization. It shows how familiar processes of visualization fit the semiotic frameworks of both Saussure and Peirce, and extends these structures using the tools of category theory to provide a general framework for understanding visualization in practice, including: Relationships between systems, data collected from those systems, renderings of those data in the form of representations, the reading of those representations to create visualizations, and the use of those visualizations to create knowledge and understanding of the system under inspection. The resulting framework is validated by demonstrating how familiar information visualization concepts (such as literalness, sensitivity, redundancy, ambiguity, generalizability, and chart junk) arise naturally from it and can be defined formally and precisely. This paper generalizes previous work on the formal characterization of visualization by, inter alia, Ziemkiewicz and Kosara and allows us to formally distinguish properties of the visualization process that previous work does not.

  20. Understanding Cloud Requirements - A Supply Chain Lifecycle Approach

    OpenAIRE

    Lindner, Mark; McDonald, Fiona; Conway, Gerry; Curry, Edward

    2011-01-01

    Cloud Computing is offering competitive advantages to companies through flexible and, scalable access to computing resources. More and more companies are moving to cloud environments; therefore understanding the requirements for this process is both important and beneficial. The requirements for migrating from a traditional computing environment to a cloud hosting environment are discussed in this paper, considering this migration from a supply chain lifecycle perspective...

  1. Understanding and Accommodating Online Social Communities: A Common Sense Approach

    Science.gov (United States)

    Lennon, Sean M.

    2013-01-01

    Online social networks such as Facebook have changed the context and definitions of socialization. Focusing on teacher use, this article considers the size and impact of these forums and the importance many young professionals feel toward them. Themed as a common sense approach, the author uses anecdotal points and discussions with…

  2. Understanding the Science-Learning Environment: A Genetically Sensitive Approach

    Science.gov (United States)

    Haworth, Claire M. A.; Davis, Oliver S. P.; Hanscombe, Ken B.; Kovas, Yulia; Dale, Philip S.; Plomin, Robert

    2013-01-01

    Previous studies have shown that environmental influences on school science performance increase in importance from primary to secondary school. Here we assess for the first time the relationship between the science-learning environment and science performance using a genetically sensitive approach to investigate the aetiology of this link. 3000…

  3. Understanding Performance Management in Schools: A Dialectical Approach

    Science.gov (United States)

    Page, Damien

    2016-01-01

    Purpose: The purpose of this paper is to provide a dialectical framework for the examination of performance management in schools. Design/Methodology/Approach: The paper is based upon a qualitative study of ten headteachers that involved in-depth semi-structured interviews. Findings: The findings identified four dialectical tensions that underpin…

  4. Understanding the edge effect in wetting: a thermodynamic approach.

    Science.gov (United States)

    Fang, Guoping; Amirfazli, A

    2012-06-26

    Edge effect is known to hinder spreading of a sessile drop. However, the underlying thermodynamic mechanisms responsible for the edge effect still is not well-understood. In this study, a free energy model has been developed to investigate the energetic state of drops on a single pillar (from upright frustum to inverted frustum geometries). An analysis of drop free energy levels before and after crossing the edge allows us to understand the thermodynamic origin of the edge effect. In particular, four wetting cases for a drop on a single pillar with different edge angles have been determined by understanding the characteristics of FE plots. A wetting map describing the four wetting cases is given in terms of edge angle and intrinsic contact angle. The results show that the free energy barrier observed near the edge plays an important role in determining the drop states, i.e., (1) stable or metastable drop states at the pillar's edge, and (2) drop collapse by liquid spilling over the edge completely or staying at an intermediate sidewall position of the pillar. This thermodynamic model presents an energetic framework to describe the functioning of the so-called "re-entrant" structures. Results show good consistency with the literature and expand the current understanding of Gibbs' inequality condition.

  5. Understanding Gulf War Illness: An Integrative Modeling Approach

    Science.gov (United States)

    2015-10-01

    research assistant Ms. Mariam Viquar, Doctor of Osteopathic Medicine (DOM) class of 2016, to continue genomic analysis of available human data under...Translational Medicine Approach to GWI: From Cells to Therapy.”  Also to promote and forward the momentum of the field, this year we have published 2... veterinarian has decided no more animals may be exposed to DFP until many palliative care studies have been conducted to see if any care conditions

  6. An imaging genetics approach to understanding social influence

    OpenAIRE

    Falk, Emily B.; Way, Baldwin M.; Jasinska, Agnes J.

    2012-01-01

    Normative social influences shape nearly every aspect of our lives, yet the biological processes mediating the impact of these social influences on behavior remain incompletely understood. In this Hypothesis, we outline a theoretical framework and an integrative research approach to the study of social influences on the brain and genetic moderators of such effects. First, we review neuroimaging evidence linking social influence and conformity to the brain's reward system. We next review neuro...

  7. An imaging genetics approach to understanding social influence

    OpenAIRE

    Emily eFalk; Emily eFalk; Baldwin eWay; Agnes eJasinska

    2012-01-01

    Normative social influences shape nearly every aspect of our lives, yet the biological processes mediating the impact of these social influences on behavior remain incompletely understood. In this Hypothesis, we outline a theoretical framework and an integrative research approach to the study of social influences on the brain and genetic moderators of such effects. First, we review neuroimaging evidence linking social influence and conformity to the brain’s reward system. We next review neur...

  8. Understanding Gulf War Illness: An Integrative Modeling Approach

    Science.gov (United States)

    2017-10-01

    high-order diffusion imaging in a rat model of Gulf War Illness. §These authors contributed equally to the work. Brain Behavior and Immunity. pii...astrocyte specific transcriptome responses to neurotoxicity. §These authors contributed equally to the work. Submitted for Internal CDC-NIOSH...Antagonist: Evaluation of Beneficial Effects for Gulf War Illness 4) GW160116 (Nathanson) Genomics approach to find gender specific mechanisms of GWI

  9. Understanding Gulf War Illness: An Integrative Modeling Approach

    Science.gov (United States)

    2016-10-01

    prepared with Dr. Craddock and other members of the CSB. (Task 4; Subtask1) c) Brainstormed with the Miller and O’Callaghan teams to design animal...for 2-day brainstorming session to review current candidate drug targets and develop methodological approach to computer- based drug screening (Sep. 24...committee, Chemical Hygiene and Biosafety. Important issues are related to DFP purchase, storage, dilution, exposure (injection). (Task 2; Subtask1

  10. A system dynamics approach to understanding the One Health concept.

    Directory of Open Access Journals (Sweden)

    Tai Xie

    Full Text Available There have been many terms used to describe the One Health concept, including movement, strategy, framework, agenda, approach, among others. However, the inter-relationships of the disciplines engaged in the One Health concept have not been well described. To identify and better elucidate the internal feedback mechanisms of One Health, we employed a system dynamics approach. First, a systematic literature review was conducted via searches in PubMed, Web of Knowledge, and ProQuest with the search terms: 'One Health' and (concept* or approach*. In addition, we used the HistCite® tool to add significant articles on One Health to the library. Then, of the 2368 articles identified, 19 were selected for evaluating the inter-relationships of disciplines engaged in One Health. Herein, we report a visually rich, theoretical model regarding interactions of various disciplines and complex problem descriptors engaged in One Health problem solving. This report provides a conceptual framework for future descriptions of the interdisciplinary engagements involved in One Health.

  11. Metagenomic approaches to understanding phylogenetic diversity in quorum sensing.

    Science.gov (United States)

    Kimura, Nobutada

    2014-04-01

    Quorum sensing, a form of cell-cell communication among bacteria, allows bacteria to synchronize their behaviors at the population level in order to control behaviors such as luminescence, biofilm formation, signal turnover, pigment production, antibiotics production, swarming, and virulence. A better understanding of quorum-sensing systems will provide us with greater insight into the complex interaction mechanisms used widely in the Bacteria and even the Archaea domain in the environment. Metagenomics, the use of culture-independent sequencing to study the genomic material of microorganisms, has the potential to provide direct information about the quorum-sensing systems in uncultured bacteria. This article provides an overview of the current knowledge of quorum sensing focused on phylogenetic diversity, and presents examples of studies that have used metagenomic techniques. Future technologies potentially related to quorum-sensing systems are also discussed.

  12. An imaging genetics approach to understanding social influence.

    Science.gov (United States)

    Falk, Emily B; Way, Baldwin M; Jasinska, Agnes J

    2012-01-01

    Normative social influences shape nearly every aspect of our lives, yet the biological processes mediating the impact of these social influences on behavior remain incompletely understood. In this Hypothesis, we outline a theoretical framework and an integrative research approach to the study of social influences on the brain and genetic moderators of such effects. First, we review neuroimaging evidence linking social influence and conformity to the brain's reward system. We next review neuroimaging evidence linking social punishment (exclusion) to brain systems involved in the experience of pain, as well as evidence linking exclusion to conformity. We suggest that genetic variants that increase sensitivity to social cues may predispose individuals to be more sensitive to either social rewards or punishments (or potentially both), which in turn increases conformity and susceptibility to normative social influences more broadly. To this end, we review evidence for genetic moderators of neurochemical responses in the brain, and suggest ways in which genes and pharmacology may modulate sensitivity to social influences. We conclude by proposing an integrative imaging genetics approach to the study of brain mediators and genetic modulators of a variety of social influences on human attitudes, beliefs, and actions.

  13. An imaging genetics approach to understanding social influence

    Directory of Open Access Journals (Sweden)

    Emily eFalk

    2012-06-01

    Full Text Available Normative social influences shape nearly every aspect of our lives, yet the biological processes mediating the impact of these social influences on behavior remain incompletely understood. In this Hypothesis, we outline a theoretical framework and an integrative research approach to the study of social influences on the brain and genetic moderators of such effects. First, we review neuroimaging evidence linking social influence and conformity to the brain’s reward system. We next review neuroimaging evidence linking social punishment (exclusion to brain systems involved in the experience of pain, as well as evidence linking exclusion to conformity. We suggest that genetic variants that increase sensitivity to social cues may predispose individuals to be more sensitive to either social rewards or punishments (or potentially both, which in turn increases conformity and susceptibility to normative social influences more broadly. To this end, we review evidence for genetic moderators of neurochemical responses in the brain, and suggest ways in which genes and pharmacology may modulate sensitivity to social influences. We conclude by proposing an integrative imaging genetics approach to the study of brain mediators and genetic modulators of a variety of social influences on human attitudes, beliefs, and actions.

  14. An imaging genetics approach to understanding social influence

    Science.gov (United States)

    Falk, Emily B.; Way, Baldwin M.; Jasinska, Agnes J.

    2012-01-01

    Normative social influences shape nearly every aspect of our lives, yet the biological processes mediating the impact of these social influences on behavior remain incompletely understood. In this Hypothesis, we outline a theoretical framework and an integrative research approach to the study of social influences on the brain and genetic moderators of such effects. First, we review neuroimaging evidence linking social influence and conformity to the brain's reward system. We next review neuroimaging evidence linking social punishment (exclusion) to brain systems involved in the experience of pain, as well as evidence linking exclusion to conformity. We suggest that genetic variants that increase sensitivity to social cues may predispose individuals to be more sensitive to either social rewards or punishments (or potentially both), which in turn increases conformity and susceptibility to normative social influences more broadly. To this end, we review evidence for genetic moderators of neurochemical responses in the brain, and suggest ways in which genes and pharmacology may modulate sensitivity to social influences. We conclude by proposing an integrative imaging genetics approach to the study of brain mediators and genetic modulators of a variety of social influences on human attitudes, beliefs, and actions. PMID:22701416

  15. Conceptual Challenges of the Systemic Approach in Understanding Cell Differentiation.

    Science.gov (United States)

    Paldi, Andras

    2018-01-01

    The cells of a multicellular organism are derived from a single zygote and genetically identical. Yet, they are phenotypically very different. This difference is the result of a process commonly called cell differentiation. How the phenotypic diversity emerges during ontogenesis or regeneration is a central and intensely studied but still unresolved issue in biology. Cell biology is facing conceptual challenges that are frequently confused with methodological difficulties. How to define a cell type? What stability or change means in the context of cell differentiation and how to deal with the ubiquitous molecular variations seen in the living cells? What are the driving forces of the change? We propose to reframe the problem of cell differentiation in a systemic way by incorporating different theoretical approaches. The new conceptual framework is able to capture the insights made at different levels of cellular organization and considered previously as contradictory. It also provides a formal strategy for further experimental studies.

  16. Genomic and Functional Approaches to Understanding Cancer Aneuploidy.

    Science.gov (United States)

    Taylor, Alison M; Shih, Juliann; Ha, Gavin; Gao, Galen F; Zhang, Xiaoyang; Berger, Ashton C; Schumacher, Steven E; Wang, Chen; Hu, Hai; Liu, Jianfang; Lazar, Alexander J; Cherniack, Andrew D; Beroukhim, Rameen; Meyerson, Matthew

    2018-04-09

    Aneuploidy, whole chromosome or chromosome arm imbalance, is a near-universal characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas, aneuploidy was correlated with TP53 mutation, somatic mutation rate, and expression of proliferation genes. Aneuploidy was anti-correlated with expression of immune signaling genes, due to decreased leukocyte infiltrates in high-aneuploidy samples. Chromosome arm-level alterations show cancer-specific patterns, including loss of chromosome arm 3p in squamous cancers. We applied genome engineering to delete 3p in lung cells, causing decreased proliferation rescued in part by chromosome 3 duplication. This study defines genomic and phenotypic correlates of cancer aneuploidy and provides an experimental approach to study chromosome arm aneuploidy. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  17. A variational approach to understanding white dwarf evolution

    Science.gov (United States)

    Wood, M. A.; Winget, D. E.

    1989-01-01

    A variational approach is used to map out the effects that uncertainties in the theoretical model parameters have upon the derived ages near the observed cutoff in the white dwarf luminosity function. Two representative sequences are assessed, simulating a white dwarf with a 50/50 C/O mixture in the core and an outer helium layer and a white dwarf with a C/O convective overshooting profile. The differential effects that the variation of selected model input quantities has on the ages are reported, and it is concluded that internal theoretical uncertainties are small and getting smaller with time, and the results underscore the power of using the observed white dwarf luminosity function for studying the history of star formation in the Galaxy.

  18. Understanding Resilient Urban Futures: A Systemic Modelling Approach

    Directory of Open Access Journals (Sweden)

    Ralph Chapman

    2013-07-01

    Full Text Available The resilience of cities in response to natural disasters and long-term climate change has emerged as a focus of academic and policy attention. In particular, how to understand the interconnectedness of urban and natural systems is a key issue. This paper introduces an urban model that can be used to evaluate city resilience outcomes under different policy scenarios. The model is the Wellington Integrated Land Use-Transport-Environment Model (WILUTE. It considers the city (i.e., Wellington as a complex system characterized by interactions between a variety of internal urban processes (social, economic and physical and the natural environment. It is focused on exploring the dynamic relations between human activities (the geographic distribution of housing and employment, infrastructure layout, traffic flows and energy consumption, environmental effects (carbon emissions, influences on local natural and ecological systems and potential natural disasters (e.g., inundation due to sea level rise and storm events faced under different policy scenarios. The model gives insights that are potentially useful for policy to enhance the city’s resilience, by modelling outcomes, such as the potential for reduction in transportation energy use, and changes in the vulnerability of the city’s housing stock and transport system to sea level rise.

  19. Holistic approach to understanding anterior knee pain. Clinical implications.

    Science.gov (United States)

    Sanchis-Alfonso, Vicente

    2014-10-01

    Anterior knee pain is one of the most frequent reasons for consultation within knee conditions. The aetiology is not well known, which explains the sometimes unpredictable results of its treatment. Normally, when we see a patient in the office with anterior knee pain, we only study and focus on the knee. If we do this, we are making a big mistake. We must not forget to evaluate the pelvis and proximal femur, as well as the psychological factors that modulate the course of the illness. Both the pelvifemoral dysfunction as well as the psychological factors (anxiety, depression, catastrophization and kinesiophobia) must be included in our therapeutic targets of the multidisciplinary treatment of anterior knee pain. We must not only focus on the knee, we must remember to "look up" to fully understand what is happening and be able to solve this difficult problem. The aetiology of anterior knee pain is multifactorial. Therefore, diagnosis and treatment of patellofemoral disorders must be individualized. Our findings stress the importance of tailoring physiotherapy, surgery and psycho-educational interventions to each patient.

  20. Systems biology approaches to understand natural products biosynthesis

    Directory of Open Access Journals (Sweden)

    Cuauhtemoc eLicona-Cassani

    2015-12-01

    Full Text Available Actinomycetes populate soils and aquatic sediments which impose biotic and abiotic challenges for their survival. As a result, actinomycetes metabolism and genomes have evolved to produce an overwhelming diversity of specialized molecules. Polyketides, non-ribosomal peptides, post-translationally modified peptides, lactams and terpenes are well known bioactive natural products with enormous industrial potential. Accessing such biological diversity has proven difficult due to the complex regulation of cellular metabolism in actinomycetes and to the sparse knowledge of their physiology. The past decade, however, has seen the development of omics technologies that have significantly contributed to our better understanding of their biology. Key observations have contributed towards a shift in the exploitation of actinomycetes biology, such as using their full genomic potential, activating entire pathways through key metabolic elicitors and pathway engineering to improve biosynthesis. Here, we review recent efforts devoted to achieving enhanced discovery, activation and manipulation of natural product biosynthetic pathways in model actinomycetes using genome-scale biological datasets.

  1. A top-bottom price approach to understanding financial fluctuations

    Science.gov (United States)

    Rivera-Castro, Miguel A.; Miranda, José G. V.; Borges, Ernesto P.; Cajueiro, Daniel O.; Andrade, Roberto F. S.

    2012-02-01

    The presence of sequences of top and bottom (TB) events in financial series is investigated for the purpose of characterizing such switching points. They clearly mark a change in the trend of rising or falling prices of assets to the opposite tendency, are of crucial importance for the players' decision and also for the market stability. Previous attempts to characterize switching points have been based on the behavior of the volatility and on the definition of microtrends. The approach used herein is based on the smoothing of the original data with a Gaussian kernel. The events are identified by the magnitude of the difference of the extreme prices, by the time lag between the corresponding events (waiting time), and by the time interval between events with a minimal magnitude (return time). Results from the analysis of the inter day Dow Jones Industrial Average index (DJIA) from 1928 to 2011 are discussed. q-Gaussian functions with power law tails are found to provide a very accurate description of a class of measures obtained from the series statistics.

  2. Statistical physics approaches to understanding the firm growth problem

    Science.gov (United States)

    Fu, Dongfeng

    This thesis applies statistical physics approaches to investigate quantitatively the size and growth of the complex system of business firms. We study the logarithm of the one-year growth rate of firms g ≡ log(S(t + 1)/S( t)) where S(t) and S( t + 1) are the sizes of firms in the year t and t + 1 measured in monetary values. Part I in this thesis reviews some main empirical results of firm size and firm growth based on different databases. They are (i) the size distribution of firms P(S) are found to be skewed (either log-normal or power-law depending on the different databases), (ii) the growth-rate distributions of firms P(g) are of Laplace form with power-law tails, (iii) the standard deviation of firm growth rates is related by a negative power-law to the firm size. The distribution of firm growth rates conditioned on firm size collapses onto a single curve, which implies that a universal functional form may exist to describe the distribution of firm growth rate. Part II models the Entry & Exit effect and firm proportional growth using a generalized preferential attachment model. The model assumes that a new firm enters the system with a constant rate; a new unit enters/exits one of existing firms preferentially, that it, the larger firms have bigger probability to obtain the new unit, and the larger firms have bigger probability to lose a unit. The model successfully explains the observations: (i) the distribution of unit number P( K) in a firm is power law with exponential tails, (ii) P (g) is of Laplace form with power-law tails with exponent 3. Part III studies the Merging & Splitting effect in the framework of Coase theory using a dynamic percolation model in a 2-dimensional lattice where each row represents a product and each column can represent a consumer; a cell is a potential transaction. The size of the firm would be represented by the number of the cells it covers in the lattice. The model explains the facts that P(S) is power-law, P(g) is tent

  3. Understanding cracking failures of coatings: A fracture mechanics approach

    Science.gov (United States)

    Kim, Sung-Ryong

    were found upon impact loading. This analysis provides a basis for a quantitative approach to measuring coating toughness.

  4. An Interdisciplinary Approach for Understanding Artworks: The Role of Music in Visual Arts Education

    Science.gov (United States)

    Pavlou, Victoria; Athansiou, Georgina

    2014-01-01

    In a world that is becoming increasingly more visual, there is a greater need to educate children to better understand images. A school subject that deals directly with image understanding is visual arts. This article discusses an interdisciplinary approach to promote art understanding, within a multimodal environment that combines art and music.…

  5. Developing Critical Understanding in HRM Students: Using Innovative Teaching Methods to Encourage Deep Approaches to Study

    Science.gov (United States)

    Butler, Michael J. R.; Reddy, Peter

    2010-01-01

    Purpose: This paper aims to focus on developing critical understanding in human resource management (HRM) students in Aston Business School, UK. The paper reveals that innovative teaching methods encourage deep approaches to study, an indicator of students reaching their own understanding of material and ideas. This improves student employability…

  6. Evaluating Two Approaches to Helping College Students Understand Evolutionary Trees through Diagramming Tasks

    Science.gov (United States)

    Perry, Judy; Meir, Eli; Herron, Jon C.; Maruca, Susan; Stal, Derek

    2008-01-01

    To understand evolutionary theory, students must be able to understand and use evolutionary trees and their underlying concepts. Active, hands-on curricula relevant to macroevolution can be challenging to implement across large college-level classes where textbook learning is the norm. We evaluated two approaches to helping students learn…

  7. From Knowing to Understanding Student Empowerment: A Narrative Approach to Research in a Middle School

    Science.gov (United States)

    Horn, Brian R.

    2015-01-01

    This paper examines how, as a teacher researcher, I employed a narrative approach to research to better understand my 8th grade Language Arts students' empowerment in school. Drawing on sociocultural theory, critical pedagogy and a narrative approach to teacher research, students' voices were privileged and compared to the systemic assumptions…

  8. Descriptive Understandings of the Nature of Science: Examining the Consensual and Family Resemblance Approaches

    Science.gov (United States)

    do Nascimento Rocha, Maristela; Gurgel, Ivã

    2017-01-01

    This paper performs a critical analysis of the consensual and family resemblance approaches to the nature of science. Despite the debate that surrounds them, between a pragmatic consensus and a more comprehensive understanding, both approaches have in common the goal of helping students to "internalize" knowledge about science in a…

  9. A grounded theory approach to the subjective understanding of urban soundscape in Sheffield

    OpenAIRE

    Liu, F.; Kang, J.

    2016-01-01

    The aim of this study is to gain a greater insight into the factors that affect individuals' preferences and understanding of urban soundscapes. Based on a grounded theory approach, with 53 participants in Sheffield, five categories have been revealed for the subjective understanding of soundscape: soundscape definition, soundscape memory, soundscape sentiment, soundscape expectation, and soundscape aesthetics. More specifically, to some extent, the value people place on sounds does not lie i...

  10. How Can a Multimodal Approach to Primate Communication Help Us Understand the Evolution of Communication?

    Directory of Open Access Journals (Sweden)

    Bridget M. Waller

    2013-07-01

    Full Text Available Scientists studying the communication of non-human animals are often aiming to better understand the evolution of human communication, including human language. Some scientists take a phylogenetic perspective, where the goal is to trace the evolutionary history of communicative traits, while others take a functional perspective, where the goal is to understand the selection pressures underpinning specific traits. Both perspectives are necessary to fully understand the evolution of communication, but it is important to understand how the two perspectives differ and what they can and cannot tell us. Here, we suggest that integrating phylogenetic and functional questions can be fruitful in better understanding the evolution of communication. We also suggest that adopting a multimodal approach to communication might help to integrate phylogenetic and functional questions, and provide an interesting avenue for research into language evolution.

  11. How can a multimodal approach to primate communication help us understand the evolution of communication?

    Science.gov (United States)

    Waller, Bridget M; Liebal, Katja; Burrows, Anne M; Slocombe, Katie E

    2013-07-18

    Scientists studying the communication of non-human animals are often aiming to better understand the evolution of human communication, including human language. Some scientists take a phylogenetic perspective, where the goal is to trace the evolutionary history of communicative traits, while others take a functional perspective, where the goal is to understand the selection pressures underpinning specific traits. Both perspectives are necessary to fully understand the evolution of communication, but it is important to understand how the two perspectives differ and what they can and cannot tell us. Here, we suggest that integrating phylogenetic and functional questions can be fruitful in better understanding the evolution of communication. We also suggest that adopting a multimodal approach to communication might help to integrate phylogenetic and functional questions, and provide an interesting avenue for research into language evolution.

  12. What's in a Domain: Understanding How Students Approach Questioning in History and Science

    Science.gov (United States)

    Portnoy, Lindsay Blau

    2013-01-01

    During their education, students are presented with information across a variety of academic domains. How students ask questions as they learn has implications for understanding, retention, and problem solving. The current research investigates the influence of age and prior knowledge on the ways students approach questioning across history and…

  13. Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life.

    NARCIS (Netherlands)

    Kaput, J.; Ommen, van B.; Kremer, B.; Priami, C.; Pontes Monteiro, J.; Morine, M.; Pepping, F.; Diaz, Z.; Fenech, M.; He, Y.; Albers, R.; Drevon, C.A.; Evelo, C.T.; Hancock, R.E.W.; Ijsselmuiden, C.; Lumey, L.H.; Minihane, A.M.; Muller, M.R.; Murgia, C.; Radonjic, M.; Sobral, B.W.S.; West Jr., K.P.

    2014-01-01

    Nutrition research, like most biomedical disciplines, adopted and often uses experimental approaches based on Beadle and Tatum’s one gene—one polypeptide hypothesis, thereby reducing biological processes to single reactions or pathways. Systems thinking is needed to understand the complexity of

  14. Understanding the Nature of Science and Scientific Progress: A Theory-Building Approach

    Science.gov (United States)

    Chuy, Maria; Scardamalia, Marlene; Bereiter, Carl; Prinsen, Fleur; Resendes, Monica; Messina, Richard; Hunsburger, Winifred; Teplovs, Chris; Chow, Angela

    2010-01-01

    In 1993 Carey and Smith conjectured that the most promising way to boost students' understanding of the nature of science is a "theory-building approach to teaching about inquiry." The research reported here tested this conjecture by comparing results from two Grade 4 classrooms that differed in their emphasis on and technological…

  15. What's in a Domain: Understanding How Students Approach Questioning in History and Science

    Science.gov (United States)

    Portnoy, Lindsay Blau; Rabinowitz, Mitchell

    2014-01-01

    How students ask questions as they learn has implications for understanding, retention, and problem solving. The current research investigates the influence of domain, age, and previous experience with content on the ways students approach questioning across history and science texts. In 3 experiments, 3rd-, 8th-, and 10th-grade students in large…

  16. Trait-based approaches for understanding microbial biodiversity and ecosystem functioning

    NARCIS (Netherlands)

    Krause, S.; Le Roux, X.; Niklaus, P.A.; van Bodegom, P.M.; Lennon, J.T.; Bertilsson, S.A.; Grossart, H.P.; Philippot, L.; Bodelier, P.L.E.

    2014-01-01

    In ecology, biodiversity-ecosystem functioning (BEF) research has seen a shift in perspective from taxonomy to function in the last two decades, with successful application of trait-based approaches. This shift offers opportunities for a deeper mechanistic understanding of the role of biodiversity

  17. Effectiveness of Instruction Based on the Constructivist Approach on Understanding Chemical Equilibrium Concepts

    Science.gov (United States)

    Akkus, Huseyin; Kadayifci, Hakki; Atasoy, Basri; Geban, Omer

    2003-01-01

    The purpose of this study was to identify misconceptions concerning chemical equilibrium concepts and to investigate the effectiveness of instruction based on the constructivist approach over traditional instruction on 10th grade students' understanding of chemical equilibrium concepts. The subjects of this study consisted of 71 10th grade…

  18. Adult Learners Understanding in Learning Islam Using the Andragogy Approach in Singapore

    Science.gov (United States)

    Kadir, Mohd Amin Bin

    2016-01-01

    This study describes adult learners understanding in learning Islam using the andragogy approach in Singapore comprising multicultural and multi-religious society. Singapore is a secular state where freedom of religion is encrypted in the constitution and Malay/Muslim comprises 13.3% of the population. Adults learn Islam to deepen their…

  19. Understanding Nature-Related Behaviors among Children through a Theory of Reasoned Action Approach

    Science.gov (United States)

    Gotch, Chad; Hall, Troy

    2004-01-01

    The Theory of Reasoned Action has proven to be a valuable tool for predicting and understanding behavior and, as such, provides a potentially important basis for environmental education program design. This study used a Theory of Reasoned Action approach to examine a unique type of behavior (nature-related activities) and a unique population…

  20. Mathematical Understanding and Proving Abilities: Experiment with Undergraduate Student by Using Modified Moore Learning Approach

    Science.gov (United States)

    Maya, Rippi; Sumarmo, Utari

    2011-01-01

    This paper reports findings of a post test experimental control group design conducted to investigate the role of modified Moore learning approach on improving students' mathematical understanding and proving abilities. Subjects of study were 56 undergraduate students of one state university in Bandung, who took advanced abstract algebra course.…

  1. The Effect of a Conceptual Change Approach on Understanding of Students' Chemical Equilibrium Concepts

    Science.gov (United States)

    Atasoy, Basri; Akkus, Huseyin; Kadayifci, Hakki

    2009-01-01

    The purpose of this study was to compare the effects of a conceptual change approach over traditional instruction on tenth-grade students' conceptual achievement in understanding chemical equilibrium. The study was conducted in two classes of the same teacher with participation of a total of 44 tenth-grade students. In this study, a…

  2. Mathematical Understanding and Proving Abilities: Experiment With Undergraduate Student By Using Modified Moore Learning Approach

    Directory of Open Access Journals (Sweden)

    Rippi Maya

    2011-07-01

    Full Text Available This paper reports findings of  a  post test experimental control group design conducted to investigate the role of modified Moore learning approach  on improving students’ mathematical understanding and proving abilities. Subject of study were 56 undergradute students of one state university in Bandung, who took advanced abstract algebra course. Instrument of study were a set test of mathematical understanding ability, a set test of mathematical proving ability, and a set of students’ opinion scale on modified Moore learning approach. Data were analyzed by using two path ANOVA. The study found that proof construction process was more difficult than mathematical understanding  task  for all students, and students still posed some difficulties on constructing mathematical proof task.  The study also found there were not differences  between students’  abilities on mathematical understanding and on proving abilities of  the both classes, and both abilities were classified as mediocre. However, in modified Moore learning approach class there were more students who got above average grades on mathematical understanding than those of conventional class. Moreover, students performed positive  opinion toward  modified Moore learning approach. They  were  active in questioning and solving problems, and in explaining their works in front of class as well, while students of conventional teaching prefered to listen to lecturer’s explanation. The study also found that there was no interaction between learning approach and students’ prior mathematics ability on mathematical understanding and proving abilities,  but  there were  quite strong  association between students’ mathematical understanding and proving abilities.Keywords:  modified Moore learning approach, mathematical understanding ability, mathematical proving ability. DOI: http://dx.doi.org/10.22342/jme.2.2.751.231-250

  3. An efficient approach to understanding and predicting the effects of multiple task characteristics on performance.

    Science.gov (United States)

    Richardson, Miles

    2017-04-01

    In ergonomics there is often a need to identify and predict the separate effects of multiple factors on performance. A cost-effective fractional factorial approach to understanding the relationship between task characteristics and task performance is presented. The method has been shown to provide sufficient independent variability to reveal and predict the effects of task characteristics on performance in two domains. The five steps outlined are: selection of performance measure, task characteristic identification, task design for user trials, data collection, regression model development and task characteristic analysis. The approach can be used for furthering knowledge of task performance, theoretical understanding, experimental control and prediction of task performance. Practitioner Summary: A cost-effective method to identify and predict the separate effects of multiple factors on performance is presented. The five steps allow a better understanding of task factors during the design process.

  4. Video-cued narrative reflection: a research approach for articulating tacit, relational, and embodied understandings.

    Science.gov (United States)

    Raingruber, Bonnie

    2003-10-01

    The author's purpose in this article is to describe the effectiveness of video-cued narrative reflection as a research approach for accessing relational, practice-based, and lived understandings. Video-cued narrative reflection provides moment-by-moment access to tacit experience. The immediate nature of the videotape captures emotional nuances, embodied perceptions, spatial influences, relational understandings, situational factors, and temporal manifestations. By watching videotaped interactions, participants are able to re-collect, re-experience, and interpret their life world. Video-cued narrative reflection allows participants to be simultaneously engaged and reflective while describing significant understandings. By inserting audiotaped reflective commentary of participants into the original videotape transcript, contextual meanings can be located and articulated more easily. Although not appropriate for all types of research, this approach offers promise for certain studies.

  5. An embodied approach to understanding: Making sense of the world through simulated bodily activity

    Directory of Open Access Journals (Sweden)

    Firat Soylu

    2016-12-01

    Full Text Available Even though understanding is a very widely used concept, both colloquially and in scholarly work, its definition is nebulous and it is not well-studied as a psychological construct, compared to other psychological constructs like learning and memory. It is hard to study understanding based on third-person behavioral data or neural data alone. Understanding refers to a first-person experience of making sense of an event or conceptual domain, and therefore requires incorporation of multiple levels of study, at the first-person (phenomenological, behavioral, and neural levels. Previously, psychological understanding was defined as a form of conscious knowing. Alternatively, biofunctional approach not only refers to conscious knowing but also extends to unconscious, implicit, automatic, and intuitive aspects of cognition. Here, to bridge these two approaches an embodied and evolutionary perspective is provided to situate biofunctional understanding in theories of embodiment, and to discuss how simulation theories of cognition, which regard simulation of sensorimotor and affective states as a central tenet of cognition, can bridge the gap between biofunctional and psychological understanding.

  6. Understanding employee motivation and organizational performance: Arguments for a set-theoretic approach

    Directory of Open Access Journals (Sweden)

    Michael T. Lee

    2016-09-01

    Full Text Available Empirical evidence demonstrates that motivated employees mean better organizational performance. The objective of this conceptual paper is to articulate the progress that has been made in understanding employee motivation and organizational performance, and to suggest how the theory concerning employee motivation and organizational performance may be advanced. We acknowledge the existing limitations of theory development and suggest an alternative research approach. Current motivation theory development is based on conventional quantitative analysis (e.g., multiple regression analysis, structural equation modeling. Since researchers are interested in context and understanding of this social phenomena holistically, they think in terms of combinations and configurations of a set of pertinent variables. We suggest that researchers take a set-theoretic approach to complement existing conventional quantitative analysis. To advance current thinking, we propose a set-theoretic approach to leverage employee motivation for organizational performance.

  7. The trouble with chemical energy: why understanding bond energies requires an interdisciplinary systems approach.

    Science.gov (United States)

    Cooper, Melanie M; Klymkowsky, Michael W

    2013-06-01

    Helping students understand "chemical energy" is notoriously difficult. Many hold inconsistent ideas about what energy is, how and why it changes during the course of a chemical reaction, and how these changes are related to bond energies and reaction dynamics. There are (at least) three major sources for this problem: 1) the way biologists talk about chemical energy (which is also the way we talk about energy in everyday life); 2) the macroscopic approach to energy concepts that is common in physics and physical sciences; and 3) the failure of chemistry courses to explicitly link molecular with macroscopic energy ideas. From a constructivist perspective, it is unlikely that students can, without a coherent understanding of such a central concept, attain a robust and accurate understanding of new concepts. However, changes are on the horizon, guided by the increasing understanding that difficult concepts require coherent, well-designed learning progressions and the new National Research Council Framework for K-12 Science Education. We provide supporting evidence for our assertions and suggestions for an interdisciplinary learning progression designed to better approach the concept of bond energies, a first step in an understanding chemical energy and behavior of reaction systems that is central to biological systems.

  8. Proteomic approaches to understanding the role of the cytoskeleton in host-defense mechanisms

    Science.gov (United States)

    Radulovic, Marko; Godovac-Zimmermann, Jasminka

    2014-01-01

    The cytoskeleton is a cellular scaffolding system whose functions include maintenance of cellular shape, enabling cellular migration, division, intracellular transport, signaling and membrane organization. In addition, in immune cells, the cytoskeleton is essential for phagocytosis. Following the advances in proteomics technology over the past two decades, cytoskeleton proteome analysis in resting and activated immune cells has emerged as a possible powerful approach to expand our understanding of cytoskeletal composition and function. However, so far there have only been a handful of studies of the cytoskeleton proteome in immune cells. This article considers promising proteomics strategies that could augment our understanding of the role of the cytoskeleton in host-defense mechanisms. PMID:21329431

  9. A General and Intuitive Approach to Understand and Compare the Torque Production Capability of AC Machines

    DEFF Research Database (Denmark)

    Wang, Dong; Lu, Kaiyuan; Rasmussen, Peter Omand

    2014-01-01

    -frame, through complicated mathematical manipulations. This is a more mathematical approach rather than explaining the physics behind torque production, which even brings a lot of difficulties to specialist. This paper introduces a general and intuitive approach to obtain the dq-frame torque equation of various...... AC machines. In this method, torque equation can be obtained based on the intuitive physical understanding of the mechanism behind torque production. It is then approved to be applicable for general case, including rotor saliency and various types of magnetomotive force sources. As an application...

  10. New approaches to characterizing and understanding biofouling of spiral wound membrane systems

    KAUST Repository

    van Loosdrecht, Mark C.M.

    2012-06-01

    Historically, biofouling research on spiral wound membrane systems is typically problem solving oriented. Membrane modules are studied as black box systems, investigated by autopsies. Biofouling is not a simple process. Many factors influence each other in a non-linear fashion. These features make biofouling a subject which is not easy to study using a fundamental scientific approach. Nevertheless to solve or minimize the negative impacts of biofouling, a clear understanding of the interacting basic principles is needed. Recent research into microbiological characterizing of biofouling, small scale test units, application of in situ visualization methods, and model approaches allow such an integrated study of biofouling. © IWA Publishing 2012.

  11. Community-based participatory research: understanding a promising approach to addressing knowledge gaps in palliative care.

    Science.gov (United States)

    Riffin, Catherine; Kenien, Cara; Ghesquiere, Angela; Dorime, Ashley; Villanueva, Carolina; Gardner, Daniel; Callahan, Jean; Capezuti, Elizabeth; Reid, M Carrington

    2016-07-01

    Concern over the need for effective and accessible healthcare for individuals with advanced chronic illness has drawn attention to the significant gaps in our knowledge of palliative medicine. To advance our understanding of this field, community-based participatory research (CBPR) is proposed as a tool for future research initiatives. This paper offers a rationale for how CBPR may be employed to address specific gaps in palliative care research. Several examples where this approach has been used previously are described, and potential obstacles to implementing this research method are delineated. Despite challenges to incorporating CBPR to palliative care research, this approach holds substantial potential to advance our current understanding of the field and promote sensitivity for future programs, practices and policies.

  12. Integrating Survey and Molecular Approaches to Better Understand Wildlife Disease Ecology

    Science.gov (United States)

    Cowled, Brendan D.; Ward, Michael P.; Laffan, Shawn W.; Galea, Francesca; Garner, M. Graeme; MacDonald, Anna J.; Marsh, Ian; Muellner, Petra; Negus, Katherine; Quasim, Sumaiya; Woolnough, Andrew P.; Sarre, Stephen D.

    2012-01-01

    Infectious wildlife diseases have enormous global impacts, leading to human pandemics, global biodiversity declines and socio-economic hardship. Understanding how infection persists and is transmitted in wildlife is critical for managing diseases, but our understanding is limited. Our study aim was to better understand how infectious disease persists in wildlife populations by integrating genetics, ecology and epidemiology approaches. Specifically, we aimed to determine whether environmental or host factors were stronger drivers of Salmonella persistence or transmission within a remote and isolated wild pig (Sus scrofa) population. We determined the Salmonella infection status of wild pigs. Salmonella isolates were genotyped and a range of data was collected on putative risk factors for Salmonella transmission. We a priori identified several plausible biological hypotheses for Salmonella prevalence (cross sectional study design) versus transmission (molecular case series study design) and fit the data to these models. There were 543 wild pig Salmonella observations, sampled at 93 unique locations. Salmonella prevalence was 41% (95% confidence interval [CI]: 37–45%). The median Salmonella DICE coefficient (or Salmonella genetic similarity) was 52% (interquartile range [IQR]: 42–62%). Using the traditional cross sectional prevalence study design, the only supported model was based on the hypothesis that abundance of available ecological resources determines Salmonella prevalence in wild pigs. In the molecular study design, spatial proximity and herd membership as well as some individual risk factors (sex, condition score and relative density) determined transmission between pigs. Traditional cross sectional surveys and molecular epidemiological approaches are complementary and together can enhance understanding of disease ecology: abundance of ecological resources critical for wildlife influences Salmonella prevalence, whereas Salmonella transmission is driven by

  13. Integrating survey and molecular approaches to better understand wildlife disease ecology.

    Directory of Open Access Journals (Sweden)

    Brendan D Cowled

    Full Text Available Infectious wildlife diseases have enormous global impacts, leading to human pandemics, global biodiversity declines and socio-economic hardship. Understanding how infection persists and is transmitted in wildlife is critical for managing diseases, but our understanding is limited. Our study aim was to better understand how infectious disease persists in wildlife populations by integrating genetics, ecology and epidemiology approaches. Specifically, we aimed to determine whether environmental or host factors were stronger drivers of Salmonella persistence or transmission within a remote and isolated wild pig (Sus scrofa population. We determined the Salmonella infection status of wild pigs. Salmonella isolates were genotyped and a range of data was collected on putative risk factors for Salmonella transmission. We a priori identified several plausible biological hypotheses for Salmonella prevalence (cross sectional study design versus transmission (molecular case series study design and fit the data to these models. There were 543 wild pig Salmonella observations, sampled at 93 unique locations. Salmonella prevalence was 41% (95% confidence interval [CI]: 37-45%. The median Salmonella DICE coefficient (or Salmonella genetic similarity was 52% (interquartile range [IQR]: 42-62%. Using the traditional cross sectional prevalence study design, the only supported model was based on the hypothesis that abundance of available ecological resources determines Salmonella prevalence in wild pigs. In the molecular study design, spatial proximity and herd membership as well as some individual risk factors (sex, condition score and relative density determined transmission between pigs. Traditional cross sectional surveys and molecular epidemiological approaches are complementary and together can enhance understanding of disease ecology: abundance of ecological resources critical for wildlife influences Salmonella prevalence, whereas Salmonella transmission is

  14. Creating the brain and interacting with the brain: an integrated approach to understanding the brain

    OpenAIRE

    Morimoto, Jun; Kawato, Mitsuo

    2015-01-01

    In the past two decades, brain science and robotics have made gigantic advances in their own fields, and their interactions have generated several interdisciplinary research fields. First, in the ‘understanding the brain by creating the brain’ approach, computational neuroscience models have been applied to many robotics problems. Second, such brain-motivated fields as cognitive robotics and developmental robotics have emerged as interdisciplinary areas among robotics, neuroscience and cognit...

  15. Unique Approach to Threat Analysis Mapping: A Malware Centric Methodology for Better Understanding the Adversary Landscape

    Science.gov (United States)

    2016-04-05

    A Unique Approach to Threat Analysis Mapping: A Malware-Centric Methodology for Better Understanding the Adversary Landscape Deana Shick Kyle...allows at- tackers to execute arbitrary code via unspecified vectors [Mitre 2016]. Again the wide landscape and usage of Adobe Flash Player made this...after-free vulnerability in Microsoft Internet Ex- plorer affecting versions 9 and 10 [Mitre 2016]. The attack landscape of these vulnerabilities was

  16. [Understanding the meaning of leadership to the undergraduate nursing student: a phenomenological approach].

    Science.gov (United States)

    Guerra, Karina Juliana; Spiri, Wilza Carla

    2013-01-01

    This study aimed at understanding the meaning of leadership to undergraduate nursing students and the expectation related to their professional practice. Phenomenology was used as theoretical framework. Fifteen undergraduate nursing students were recruited as subjects and answered the following question: "What do you understand by leadership, and how can it be applied in your professional practice?" The topics which were revealed and analyzed, Leadership Styles and Leadership Exercise, enabled us to understand that the meaning attributed to leadership is unveiled as a dynamic process, and the style adopted is the form to lead a team; therefore, an ideal leadership style does not exist. In teaching, the leadership style began to be discussed when the participant forms of personnel management were approached. In leadership practice, the dissociation between leadership theory and practice is emphasized, pointing out that integration with practice is relevant for leadership learning.

  17. Trait-based approaches for understanding microbial biodiversity and ecosystem functioning.

    Science.gov (United States)

    Krause, Sascha; Le Roux, Xavier; Niklaus, Pascal A; Van Bodegom, Peter M; Lennon, Jay T; Bertilsson, Stefan; Grossart, Hans-Peter; Philippot, Laurent; Bodelier, Paul L E

    2014-01-01

    In ecology, biodiversity-ecosystem functioning (BEF) research has seen a shift in perspective from taxonomy to function in the last two decades, with successful application of trait-based approaches. This shift offers opportunities for a deeper mechanistic understanding of the role of biodiversity in maintaining multiple ecosystem processes and services. In this paper, we highlight studies that have focused on BEF of microbial communities with an emphasis on integrating trait-based approaches to microbial ecology. In doing so, we explore some of the inherent challenges and opportunities of understanding BEF using microbial systems. For example, microbial biologists characterize communities using gene phylogenies that are often unable to resolve functional traits. Additionally, experimental designs of existing microbial BEF studies are often inadequate to unravel BEF relationships. We argue that combining eco-physiological studies with contemporary molecular tools in a trait-based framework can reinforce our ability to link microbial diversity to ecosystem processes. We conclude that such trait-based approaches are a promising framework to increase the understanding of microbial BEF relationships and thus generating systematic principles in microbial ecology and more generally ecology.

  18. Trait-based approaches for understanding microbial biodiversity and ecosystem functioning

    Directory of Open Access Journals (Sweden)

    Sascha eKrause

    2014-05-01

    Full Text Available In ecology, biodiversity-ecosystem functioning (BEF research has seen a shift in perspective from taxonomy to function in the last two decades, with successful application of trait-based approaches. This shift offers opportunities for a deeper mechanistic understanding of the role of biodiversity in maintaining multiple ecosystem processes and services. In this paper, we highlight studies that have focused on BEF of microbial communities with an emphasis on integrating trait-based approaches to microbial ecology. In doing so, we explore some of the inherent challenges and opportunities of understanding BEF using microbial systems. For example, microbial biologists characterize communities using gene phylogenies that are often unable to resolve functional traits. Additionally, experimental designs of existing microbial BEF studies are often inadequate to unravel BEF relationships. We argue that combining eco-physiological studies with contemporary molecular tools in a trait-based framework can reinforce our ability to link microbial diversity to ecosystem processes. We conclude that such trait-based approaches are a promising framework to increase the understanding of microbial BEF relationships and thus generating systematic principles in microbial ecology and more generally ecology.

  19. Trait-based approaches for understanding microbial biodiversity and ecosystem functioning

    Science.gov (United States)

    Krause, Sascha; Le Roux, Xavier; Niklaus, Pascal A.; Van Bodegom, Peter M.; Lennon, Jay T.; Bertilsson, Stefan; Grossart, Hans-Peter; Philippot, Laurent; Bodelier, Paul L. E.

    2014-01-01

    In ecology, biodiversity-ecosystem functioning (BEF) research has seen a shift in perspective from taxonomy to function in the last two decades, with successful application of trait-based approaches. This shift offers opportunities for a deeper mechanistic understanding of the role of biodiversity in maintaining multiple ecosystem processes and services. In this paper, we highlight studies that have focused on BEF of microbial communities with an emphasis on integrating trait-based approaches to microbial ecology. In doing so, we explore some of the inherent challenges and opportunities of understanding BEF using microbial systems. For example, microbial biologists characterize communities using gene phylogenies that are often unable to resolve functional traits. Additionally, experimental designs of existing microbial BEF studies are often inadequate to unravel BEF relationships. We argue that combining eco-physiological studies with contemporary molecular tools in a trait-based framework can reinforce our ability to link microbial diversity to ecosystem processes. We conclude that such trait-based approaches are a promising framework to increase the understanding of microbial BEF relationships and thus generating systematic principles in microbial ecology and more generally ecology. PMID:24904563

  20. A neurogenetics approach to understanding individual differences in brain, behavior, and risk for psychopathology.

    Science.gov (United States)

    Bogdan, R; Hyde, L W; Hariri, A R

    2013-03-01

    Neurogenetics research has begun to advance our understanding of how genetic variation gives rise to individual differences in brain function, which, in turn, shapes behavior and risk for psychopathology. Despite these advancements, neurogenetics research is currently confronted by three major challenges: (1) conducting research on individual variables with small effects, (2) absence of detailed mechanisms, and (3) a need to translate findings toward greater clinical relevance. In this review, we showcase techniques and developments that address these challenges and highlight the benefits of a neurogenetics approach to understanding brain, behavior and psychopathology. To address the challenge of small effects, we explore approaches including incorporating the environment, modeling epistatic relationships and using multilocus profiles. To address the challenge of mechanism, we explore how non-human animal research, epigenetics research and genome-wide association studies can inform our mechanistic understanding of behaviorally relevant brain function. Finally, to address the challenge of clinical relevance, we examine how neurogenetics research can identify novel therapeutic targets and for whom treatments work best. By addressing these challenges, neurogenetics research is poised to exponentially increase our understanding of how genetic variation interacts with the environment to shape the brain, behavior and risk for psychopathology.

  1. Applying theory-driven approaches to understanding and modifying clinicians' behavior: what do we know?

    Science.gov (United States)

    Perkins, Matthew B; Jensen, Peter S; Jaccard, James; Gollwitzer, Peter; Oettingen, Gabriele; Pappadopulos, Elizabeth; Hoagwood, Kimberly E

    2007-03-01

    Despite major recent research advances, large gaps exist between accepted mental health knowledge and clinicians' real-world practices. Although hundreds of studies have successfully utilized basic behavioral science theories to understand, predict, and change patients' health behaviors, the extent to which these theories-most notably the theory of reasoned action (TRA) and its extension, the theory of planned behavior (TPB)-have been applied to understand and change clinician behavior is unclear. This article reviews the application of theory-driven approaches to understanding and changing clinician behaviors. MEDLINE and PsycINFO databases were searched, along with bibliographies, textbooks on health behavior or public health, and references from experts, to find article titles that describe theory-driven approaches (TRA or TPB) to understanding and modifying health professionals' behavior. A total of 19 articles that detailed 20 studies described the use of TRA or TPB and clinicians' behavior. Eight articles describe the use of TRA or TPB with physicians, four relate to nurses, three relate to pharmacists, and two relate to health workers. Only two articles applied TRA or TPB to mental health clinicians. The body of work shows that different constructs of TRA or TPB predict intentions and behavior among different groups of clinicians and for different behaviors and guidelines. The number of studies on this topic is extremely limited, but they offer a rationale and a direction for future research as well as a theoretical basis for increasing the specificity and efficiency of clinician-targeted interventions.

  2. Support-vector-based emergent self-organising approach for emotional understanding

    Science.gov (United States)

    Nguwi, Yok-Yen; Cho, Siu-Yeung

    2010-12-01

    This study discusses the computational analysis of general emotion understanding from questionnaires methodology. The questionnaires method approaches the subject by investigating the real experience that accompanied the emotions, whereas the other laboratory approaches are generally associated with exaggerated elements. We adopted a connectionist model called support-vector-based emergent self-organising map (SVESOM) to analyse the emotion profiling from the questionnaires method. The SVESOM first identifies the important variables by giving discriminative features with high ranking. The classifier then performs the classification based on the selected features. Experimental results show that the top rank features are in line with the work of Scherer and Wallbott [(1994), 'Evidence for Universality and Cultural Variation of Differential Emotion Response Patterning', Journal of Personality and Social Psychology, 66, 310-328], which approached the emotions physiologically. While the performance measures show that using the full features for classifications can degrade the performance, the selected features provide superior results in terms of accuracy and generalisation.

  3. Biomechanical approaches to understanding the potentially injurious demands of gymnastic-style impact landings

    Directory of Open Access Journals (Sweden)

    Gittoes Marianne JR

    2012-01-01

    Full Text Available Abstract Gymnasts are exposed to a high incidence of impact landings due to the execution of repeated dismount performances. Biomechanical research can help inform recent discussions surrounding a proposed rule change in potentially injurious gymnastic dismounting. The review examines existing understanding of the mechanisms influencing the impact loads incurred in gymnastic-style landings achieved using biomechanical approaches. Laboratory-based and theoretical modelling research of inherent and regulatory mechanisms is appraised. The integration of the existing insights into injury prevention interventions studies is further considered in the appraisals. While laboratory-based studies have traditionally been favoured, the difficulty in controlling and isolating mechanisms of interest has partially restricted the understanding gained. An increase in the use of theoretical approaches has been evident over the past two decades, which has successfully enhanced insight into less readily modified mechanisms. For example, the important contribution of mass compositions and 'tuned' mass coupling responses to impact loading has been evidenced. While theoretical studies have advanced knowledge in impact landing mechanics, restrictions in the availability of laboratory-based input data have suppressed the benefits gained. The advantages of integrating laboratory-based and theoretical approaches in furthering scientific understanding of loading mechanisms have been recognised in the literature. Since a multi-mechanism contribution to impact loading has been evident, a deviation away from studies examining isolated mechanisms may be supported for the future. A further scientific understanding of the use of regulatory mechanisms in alleviating a performer's inherent injury predisposition may subsequently be gained and used to inform potential rule changes in gymnastics. While the use of controlled studies for providing scientific evidence for the

  4. Applying a social network analysis (SNA) approach to understanding radiologists' performance in reading mammograms

    Science.gov (United States)

    Tavakoli Taba, Seyedamir; Hossain, Liaquat; Heard, Robert; Brennan, Patrick; Lee, Warwick; Lewis, Sarah

    2017-03-01

    Rationale and objectives: Observer performance has been widely studied through examining the characteristics of individuals. Applying a systems perspective, while understanding of the system's output, requires a study of the interactions between observers. This research explains a mixed methods approach to applying a social network analysis (SNA), together with a more traditional approach of examining personal/ individual characteristics in understanding observer performance in mammography. Materials and Methods: Using social networks theories and measures in order to understand observer performance, we designed a social networks survey instrument for collecting personal and network data about observers involved in mammography performance studies. We present the results of a study by our group where 31 Australian breast radiologists originally reviewed 60 mammographic cases (comprising of 20 abnormal and 40 normal cases) and then completed an online questionnaire about their social networks and personal characteristics. A jackknife free response operating characteristic (JAFROC) method was used to measure performance of radiologists. JAFROC was tested against various personal and network measures to verify the theoretical model. Results: The results from this study suggest a strong association between social networks and observer performance for Australian radiologists. Network factors accounted for 48% of variance in observer performance, in comparison to 15.5% for the personal characteristics for this study group. Conclusion: This study suggest a strong new direction for research into improving observer performance. Future studies in observer performance should consider social networks' influence as part of their research paradigm, with equal or greater vigour than traditional constructs of personal characteristics.

  5. Group model building: a participatory approach to understanding and acting on systems.

    Science.gov (United States)

    Siokou, Christine; Morgan, Rebecca; Shiell, Alan

    2014-11-28

    With mounting appreciation of the complexity of chronic disease, there is a growing need to understand the systemic causes of current health trends. This will support the development of a prevention system and the use of systems thinking to achieve better, more equitable and more sustainable health outcomes. With new language and a need to change our thinking, the push towards systems practice in preventive health is challenging, and calls for a method to support its application. Group model building (GMB) is a participatory approach that is widely used to build the capacity of practitioners to think in a systems way. However, it is a resource-intensive approach that requires high-level buy-in and the investment of time. We discuss the evidence, including a systematic review of the literature examining the effectiveness of GMB approaches across a wide range of contexts. The results of the review are generally positive and suggest that GMB improves problem understanding, increases engagement in systems thinking, builds confidence in the use of systems ideas and develops consensus for action among diverse stakeholders.

  6. Understanding the PxS Aspect of Within-Person Variation: A Variance Partitioning Approach

    Directory of Open Access Journals (Sweden)

    Brian eLakey

    2016-01-01

    Full Text Available This article reviews a variance partitioning approach to within-person variation based on Generalizability (G Theory and the Social Relations Model (SRM. The approach conceptualizes an important part of within-person variation as Person x Situation (PxS interactions: differences among persons in their profiles of responses across the same situations. The approach provided the first quantitative method for capturing within-person variation and demonstrated very large PxS effects for a wide range of constructs. These include anxiety, five-factor personality traits, perceived social support, leadership, and task performance. Although PxS effects are commonly very large, conceptual and analytic obstacles have thwarted consistent progress. For example, how does one develop a psychological, versus purely statistical, understanding of PxS effects? How does one forecast future behavior when the criterion is a PxS effect? How can understanding PxS effects contribute to psychological theory? This review describes potential solutions to these and other problems developed in the course of conducting research on the PxS aspect of social support. Additional problems that need resolution are identified.

  7. Applying Within-Family Differences Approaches to Enhance Understanding of the Complexity of Intergenerational Relations.

    Science.gov (United States)

    Suitor, J Jill; Gilligan, Megan; Pillemer, Karl; Fingerman, Karen L; Kim, Kyungmin; Silverstein, Merril; Bengtson, Vern L

    2017-12-15

    The role of family relationships in the lives of older adults has received substantial attention in recent decades. Scholars have increasingly looked beyond simple models of family relations to approaches that recognize the complex and sometimes contradictory nature of these ties. One of the most exciting conceptual and methodological developments is the application of within-family differences approaches. In this paper, we focus on the ways in which such within-family approaches can extend the understanding of patterns and consequences of intergenerational ties in adulthood. Following a review of the conceptual underpinnings of within-family differences approaches, we provide empirical illustrations of these approaches from three projects conducted in the United States: the Family Exchanges Study (FES), the Longitudinal Study of Generations (LSOG), and the Within-Family Differences Study (WFDS). Analyses from the FES, LSOG, and WFDS reveal differences in the consequences of patterns of intergenerational relations found when using within-family compared to between-family approaches. In particular, these analyses demonstrate considerable variation within families that shapes patterns and consequences of parent-adult child ties that is masked when such variations are not taken into account. Within-family differences approaches have been shown to shed new light on intergenerational relations. Despite the value of within-family designs, their use may be limited by the higher investment of finances and time required to implement such studies. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  8. A Diagrammatic Approach to Understanding Complex Eco-Social Interactions in Kathmandu, Nepal

    Directory of Open Access Journals (Sweden)

    R. Cynthia. Neudoerffer

    2005-12-01

    Full Text Available As part of developing an international network of community-based ecosystem approaches to health, a project was undertaken in a densely populated and socio-economically diverse area of Kathmandu, Nepal. Drawing on hundreds of pages of narrative reports based on surveys, interviews, secondary data, and focus groups by trained Nepalese facilitators, the authors created systemic depictions of relationships between multiple stakeholder groups, ecosystem health, and human health. These were then combined to examine interactions among stakeholders, activities, concerns, perceived needs, and resource states (ecosystem health indicators. These qualitative models have provided useful heuristics for both community members and research scholars to understand the eco-social systems in which they live; many of the strategies developed by the communities and researchers to improve health intuitively drew on this systemic understanding. The diagrams enabled researchers and community participants to explicitly examine relationships and conflicts related to health and environmental issues in their community.

  9. Understanding Solvent Spreading for Langmuir Deposition of Nanomaterial Films: A Hansen Solubility Parameter Approach.

    Science.gov (United States)

    Large, Matthew J; Ogilvie, Sean P; King, Alice A K; Dalton, Alan B

    2017-12-26

    To prepare high-quality Langmuir films of 2D materials it is important to select a solvent optimized for both exfoliation and spreading at the air-water interface. Whereas it is generally accepted that exfoliation and stabilization of 2D materials is well-described using the Hansen solubility parameter theory, a complementary description of solvent spreading behavior is lacking. To this end we develop an understanding of solvent spreading using a Hansen solubility parameter framework. Our model accurately predicts the behavior of both water-immiscible and water-miscible solvents in Langmuir film formation experiments. We demonstrate that spreading behavior can be modified by controlling the surface pressure of the subphase using an amphiphilic species and accordingly utilize this approach to determine the maximum spreading pressure for a selection of solvents. Ultimately, by building on this understanding we open up additional routes to optimize the preparation of Langmuir films of 2D materials and other nanoparticles.

  10. Landslides in everyday life: An interdisciplinary approach to understanding vulnerability in the Himalayas

    Science.gov (United States)

    Sudmeier-Rieux, K.; Breguet, A.; Dubois, J.; Jaboyedoff, M.

    2009-04-01

    Several thousand landslides were triggered by the Kashmir earthquake, scarring the hillside with cracks. Monsoon rains continue to trigger landslides, which have increased the exposure of populations because of lost agricultural lands, blocked roads and annual fatalities due to landslides. The great majority of these landslides are shallow and relatively small but greatly impacting the population. In this region, landslides were a factor before the earthquake, mainly due to road construction and gravel excavation, but the several thousand landslides triggered by the earthquake have completely overwhelmed the local population and authorities. In Eastern Nepal, the last large earthquake to hit this region occurred in 1988, also triggering numerous landslides and cracks. Here, landslides can be considered a more common phenomenon, yet coping capacities amount to local observations of landslide movement, subsequent abandonment of houses and land as they become too dangerous. We present a comparative case study from Kashmir, Pakistan and Eastern Nepal, highlighting an interdisciplinary approach to understanding the complex interactions between land use, landslides and vulnerability. Our approach sets out to understand underlying causes of the massive landslides triggered by the 2005 earthquake in Kashmir, Pakistan, and also the increasing number of landslides in Nepal. By approaching the issue of landslides from multiple angles (risk perceptions, land use, local coping capacities, geological assessment, risk mapping) and multiple research techniques (remote sensing, GIS, geological assessment, participatory mapping, focus groups) we are better able to create a more complete picture of the "hazardscape". We find that by combining participatory social science research with hazard mapping, we obtain a more complete understanding of underlying causes, coping strategies and possible mitigation options, placing natural hazards in the context of everyday life. This method is

  11. Dhat syndrome: Evolution of concept, current understanding, and need of an integrated approach

    Directory of Open Access Journals (Sweden)

    Sujita Kumar Kar

    2015-01-01

    Full Text Available Dhat syndrome has often been construed as a culture-bound sexual neurosis of the Indian subcontinent. Symptoms similar to that of Dhat syndrome has been described in other cultures across different time periods. The present paper looks at the evolution of the concept of Dhat syndrome in India. The review also takes an overview of the current understanding of this syndrome in terms of nosological status as a distinct entity and its "culture-bound" status. The narrative finally attempts to discuss the integrated approach for the treatment of this disorder.

  12. The radiographer-patient relationship: Enhancing understanding using a transactional analysis approach

    International Nuclear Information System (INIS)

    Booth, Lisa

    2008-01-01

    Purpose: Government initiatives such as the NHS Plan, the NHS Key Skills Framework and the NHS Career framework place communication at the centre of effective patient care, and role/career development. All advocate a patient-centred approach to dealing with patients, through open communication styles that encourage patients to become active participants in their care. Previous research, that has investigated communication in diagnostic radiography, demonstrated a preference for practitioner-centred, rather than patient-centred approaches to communication, however, there is little evidence to suggest why this should be the case or how a more patient-centred approach might be encouraged. The present study therefore sought to explore factors that influence communication in diagnostic radiography, with the view to understanding the barriers to patient-centred care. Method: Semi-structured group interviews took place with 12 radiographers, across two NHS trusts, with the aim of understanding their communication with patients and the factors that influence it. An open coding approach was used to analyse the data. Results: Four attitude categories were identified as influencing the communication used by diagnostic radiographers. 1. Characteristics of the radiographer. 2. Characteristics of the patient. 3. The need to produce a diagnostic image. 4. The need to keep the department running. Conclusion: Radiographer-patient communication is evidently influenced by these four attitude categories. If patient-centred styles of communication are to be encouraged, these factors need to be recognised and taken account of in the selection, education/training and workforce planning of diagnostic radiographers

  13. Constructive Approaches for Understanding the Origin of Self-Replication and Evolution

    Directory of Open Access Journals (Sweden)

    Norikazu Ichihashi

    2016-07-01

    Full Text Available The mystery of the origin of life can be divided into two parts. The first part is the origin of biomolecules: under what physicochemical conditions did biomolecules such as amino acids, nucleotides, and their polymers arise? The second part of the mystery is the origin of life-specific functions such as the replication of genetic information, the reproduction of cellular structures, metabolism, and evolution. These functions require the coordination of many different kinds of biological molecules. A direct strategy to approach the second part of the mystery is the constructive approach, in which life-specific functions are recreated in a test tube from specific biological molecules. Using this approach, we are able to employ design principles to reproduce life-specific functions, and the knowledge gained through the reproduction process provides clues as to their origins. In this mini-review, we introduce recent insights gained using this approach, and propose important future directions for advancing our understanding of the origins of life.

  14. The Scientific Approach Learning: How prospective science teachers understand about questioning

    Science.gov (United States)

    Wiyanto; Nugroho, S. E.; Hartono

    2017-04-01

    In the new curriculum, questioning is one of theaspects of scientific approach learning. It means teachers should facilitate students to ask their questions during science learning. The purpose of this research was to reveal the prospective science teachers’ understanding about questioning and how the science teachers implement of that in the scientific approach learning. Data of the prospective science teachers’ understanding was explored from their teaching plan that produced during microteaching. The microteaching is an activity that should be followed by students before they conduct partnership program in school. Data about theimplementation of questioning that conducted by theteacher was be collected by video-assisted observation in junior school science class. The results showed that majority of the prospective science teachers had difficulty to write down in their teaching plan about how to facilitate students to ask their questions, even majority of them understood that questioning is not students’ activity, but it is an activity that should be done by teachers. Based on the observation showed that majority of teachers did not yet implement a learning that facilitates students to ask their questions.

  15. A Theoretical Approach to Understanding Population Dynamics with Seasonal Developmental Durations

    Science.gov (United States)

    Lou, Yijun; Zhao, Xiao-Qiang

    2017-04-01

    There is a growing body of biological investigations to understand impacts of seasonally changing environmental conditions on population dynamics in various research fields such as single population growth and disease transmission. On the other side, understanding the population dynamics subject to seasonally changing weather conditions plays a fundamental role in predicting the trends of population patterns and disease transmission risks under the scenarios of climate change. With the host-macroparasite interaction as a motivating example, we propose a synthesized approach for investigating the population dynamics subject to seasonal environmental variations from theoretical point of view, where the model development, basic reproduction ratio formulation and computation, and rigorous mathematical analysis are involved. The resultant model with periodic delay presents a novel term related to the rate of change of the developmental duration, bringing new challenges to dynamics analysis. By investigating a periodic semiflow on a suitably chosen phase space, the global dynamics of a threshold type is established: all solutions either go to zero when basic reproduction ratio is less than one, or stabilize at a positive periodic state when the reproduction ratio is greater than one. The synthesized approach developed here is applicable to broader contexts of investigating biological systems with seasonal developmental durations.

  16. The Means-End Approach to Understanding Customer Values of a On-Line Newspaper

    Directory of Open Access Journals (Sweden)

    André Luiz Maranhão de Souza Leão

    2007-01-01

    Full Text Available Customer value is understood as one of the constructs that best explains consumer decision making. Its proposal is to understand how consumers translate product or service characteristics and consequences of use into personal self-relevant values. The means-end theory is a way of systematically thinking in this hierarchicalrepresentation. The most commonly used method to achieve means-end chains is laddering. This theory and method were used to understand customer values of an important on-line Brazilian newspaper, which is an innovative approach, since on-line laddering is uncommon. The findings indicate that values related to goals of a personal nature are the most important ones. However, other values indicate the increase of the public man pointing to an alternative vision of what is commonly thought of as the contemporary isolated and selfish human. Academic research could benefit from a broader understanding and use of the means-end theory and laddering on the Web. Future research for managerial practices is warranted in areas such as segmentation, satisfaction measuring and customer value reevaluation, in addition to copy tests.

  17. Understanding and assessing potential serious adverse events: a practical approach to understanding the benefits and harm of psoriasis treatments.

    Science.gov (United States)

    Papp, Kim; Guenther, Lyn; Shear, Neil; Binder, Carin; Tan, Jerry; Lynde, Charles; Gulliver, Wayne; Stang, Paul

    2013-01-01

    Any therapeutic intervention carries with it the potential for benefit and harm. Generally, benefit is far more common than risk; however, risk aversion drives many of the treatment decisions made by patients and their physicians. To provide guidelines to help clinicians improve their understanding of causality and the interpretation of harm. A group of dermatologists involved in data safety monitoring boards, clinical trial investigators, and a clinical epidemiologist identified the need for practical advice on how to understand and explain causality and harm and combined to share their knowledge. An explanation of how data are collected and the environment that shapes the data seen by clinicians is presented. The article spans an overview of the regulatory environment that informs trial design for regulatory approval to a description of types of designs that inform safety and techniques, such as the rule of three, to provide guidance to clinicians in interpreting the data. Communicating the potential for harm to patients is critical. Placing the potential for rare and serious risks into perspective for the patient is as important as discussing the potential benefits of medication.

  18. Scaffolded problem-solving, learning approaches and understanding of concepts in an introductory college physics class

    Science.gov (United States)

    Haack, Constance

    This study was an exploration of students' use of scaffolded problems as part of their homework in an introductory calculus-based physics class. The study included consideration of the possible relationship of students' meaningful and rote learning approaches. The sample was comprised of 48 students who had completed all study instruments. Of this number, 23 did homework assignments that included scaffolded problems that had been divided into multiple steps that simplify, highlight, and organize the knowledge associated with the problem solving process. The other 25 students did non-scaffolded homework assignments. The Mechanics Baseline Test, given at the beginning of the study, measured students' prior knowledge of physics concepts. The Learning Approach Questionnaire, also given at the beginning of the study, measured students' meaningful and rote approaches to learning. Student responses to 6 qualitative physics problems and their selection of concepts associated with 4 quantitative physics problems was a gauge of their understanding of physics concepts. These 10 problems were distributed between 2 classroom examinations given during the study. At the end of the study 4 students who had done scaffolded homework problems and 4 students who had done non-scaffolded homework problems participated in think aloud protocols. They verbalized their thoughts as they attempted to solve 2 physics problems. Characterizations of individual problem solving approaches emerged from the think aloud protocols. An analysis of statistical data showed that students who did scaffolded problems attained significantly greater understanding of physics concepts than students who did non-scaffolded assignments. There were no significant differences by learning approaches, and no significant interactions. This indicates that scaffolded homework problems may benefit students regardless of learning orientation. Think aloud protocols revealed patterns of difference between students who had

  19. Time to re-think picky eating?: a relational approach to understanding picky eating.

    Science.gov (United States)

    Walton, Kathryn; Kuczynski, Leon; Haycraft, Emma; Breen, Andrea; Haines, Jess

    2017-05-05

    Estimates of picky eating are quite high among young children, with 14-50% of parents identifying their preschoolers as picky eaters. Dietary intake and preferences during the preschool years are characterized by slowing growth rates and children developing a sense of autonomy over their feeding and food selection. We argue that the current conceptualization of picky eating defines acts of resistance or expressions of preference (acts of autonomy) by a child as deviant behaviour. This conceptualization has guided research that uses a unidirectional, parent to child approach to understanding parent-child feeding interactions. By reviewing the current feeding literature and drawing parallels from the rich body of child socialization literature, we argue that there is a need to both re-examine the concept and parent/clinician perspectives on picky eating. Thus, the objective of this paper is two-fold: 1) We argue for a reconceptualization of picky eating whereby child agency is considered in terms of eating preferences rather than categorized as compliant or non-compliant behaviour, and 2) We advocate the use of bi-directional relational models of causality and appropriate methodology to understanding the parent-child feeding relationship. Researchers are often interested in understanding how members in the parent-child dyad affect one another. Although many tend to focus on the parent to child direction of these associations, findings from child socialization research suggest that influence is bidirectional and non-linear such that parents influence the actions and cognitions of children and children influence the actions and cognitions of parents. Bi-directional models of causality are needed to correctly understand parent-child feeding interactions. A reconceptualization of picky eating may elucidate the influence that parental feeding practices and child eating habits have on each other. This may allow health professionals to more effectively support parents in

  20. Proteome Analysis—A Novel Approach to Understand the Pathogenesis of Type 1 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Allan E. Karlsen

    2001-01-01

    Full Text Available Type 1 (insulin-dependent diabetes mellitus (T1DM is associated with a specific destruction of the insulin-producing beta-cells in the islets of Langerhans. Several factors, e.g. genetic, environmental and immunologial, may be involved in the etiology and pathogenesis of T1DM. Autoreactive Tand B-lymphocytes, together with macrophages infiltrate the islets during the pathogenesis, releasing a mixture of cytokines, demonstrated to be specifically toxic to the beta-cells within the islets. Our goal is to understand the molecular mechanisms responsible for the beta-cell specific toxicity enabling us to design novel intervention strategies in T1DM. The proteome approach allows us to get a detailed picture of the beta-cell proteins, which change expression level or are post-translationally modified in different in vitro and in vivo models of T1DM-associated beta-cell destruction. Combining the information obtained from this extended proteome approach, with that of genetic-, transcriptome- and candidategene approaches, we believe that it is possible to reach this goal.

  1. Black, grey and white-box approaches to understanding catchment-wide hydrologic connectivity

    Science.gov (United States)

    Ali, G. A.; Roy, A. G.

    2009-12-01

    Connectivity is associated with nonlinear hydrological responses as it is believed to lead to drastic changes in the delivery of stormwater to the stream. Quantitative evidence of connectivity is therefore needed if the concept is to serve as a diagnostic tool for hydrologic behaviours. Recent publications advocate that geostatistical connectivity is a universal measure as it transcends catchment idiosyncracies and allows for the detection of transitions and thresholds in flow processes. Yet, the geostatistical framework failed to reflect threshold change in runoff response in a temperate humid forested catchment (Mont St-Hilaire, Quebec). In this study based on a forested catchment from the Canadian Shield (St-Hippolyte, Quebec), we use three types of hydrological data analysis in searching for evidence of connectivity: (1) statistical classification techniques applied to meteorological records and storm hydrographs; (2) end-member mixing computations performed on stream and source areas geochemistry; and (3) catchment-wide multiple-depths soil moisture data subjected to pattern analysis. These methods correspond respectively to black, grey and white-box approaches towards understanding connectivity. Since the methods can be discriminated by accessibility, physical basis, robustness and spatial discretization, results obtained are compared to assess catchment behavior and prediction uncertainty. The black-box approach reveals that catchment responses, labeled as low/high magnitude and slow/quick timing, can be predicted from meteorological thresholds. It yields indirect evidence of connectivity by suggesting that a relationship between response types and antecedent conditions can be found if assumed nonlinear. The grey-box approach is helpful in identifying time-variable contributing sources to streamflow. Intermediate discharge levels are fed by an enhanced near-surface riparian-stream connection, while both riparian and hillslope areas produce overland flow when

  2. Toward the conceptual and quantitative understanding of biosolids conditioning: the gel approach.

    Science.gov (United States)

    Dursun, Derya; Dentel, Steven K

    2009-01-01

    Proper chemical conditioning of wastewater solids is crucial for both operational and economic reasons, but the process has defied satisfactory description to date, in either conceptual or quantitative terms. In this research, a new conceptual model of biosolids structure--likening it to a colloidal gel--was assessed as a means of interpreting conditioning mechanisms. The basis of the gel approach lies in the colligative properties that are altered by lowering of the solvent chemical potential by introducing a solute. Results indicate that inorganic conditioners form precipitates and complexes thus collapsing the gel network and forming particulates, whereas organic polymers lead to heterogeneous collapse with limited diffusion inside the gel. A gel model, based on the osmotic pressure, was found reasonably successful in defining the conditioning efficacy of biosolids. Beyond the model's fundamental value, these results validate a new way of understanding how conditioning and dewatering operate, which should help to improve the selection and optimization of these processes.

  3. High-resolution modeling approaches to understanding changes in extreme precipitation projections

    Science.gov (United States)

    Mahoney, K. M.; Alexander, M. A.; Thompson, G.; Scott, J. D.; Barsugli, J. J.

    2011-12-01

    One of the challenges inherent to understanding the effect of global climate change on precipitation extremes is the mismatch of scale. Climate models simulate large-scale patterns of long-term change, while weather models generally diagnose small-scale weather phenomena such as extreme rainfall. Therefore, understanding the potential effects of global-scale changes on local-scale weather requires new research approaches to connect questions and processes across weather and climate scales. This study represents one such integrated approach by investigating projected changes in warm-season extreme precipitation events using a dynamical downscaling framework that sequentially interfaces climate- and weather-scale data. Focusing on the Colorado Front Range, global simulations are first downscaled to a medium/regional-scale resolution; the resulting simulations are then further downscaled using a high-resolution weather model. The high-resolution model is able to explicitly simulate intense thunderstorms using 1.3-km grid spacing, thus resolving the small-scale physical processes that generate extreme precipitation. Physical process explanations are sought for projected changes in rainfall amount, hail occurrence, and flood risk. Past and future extreme event simulations are compared with respect to environmental drivers such as low-level instability (e.g., CAPE), large-scale forcing, and vertical temperature and moisture profiles. The events are also examined for systematic differences in storm-scale processes such as updraft strength, hail production and hail melting, dry air entrainment, and downdraft formation. Qualitative and quantitative consistency (or the lack thereof) across global, regional, and local-scale simulations is also explored.

  4. Mass Spectrometry-Based Approaches to Understand the Molecular Basis of Memory

    Science.gov (United States)

    Pontes, Arthur H.; de Sousa, Marcelo V.

    2016-01-01

    The central nervous system is responsible for an array of cognitive functions such as memory, learning, language, and attention. These processes tend to take place in distinct brain regions; yet, they need to be integrated to give rise to adaptive or meaningful behavior. Since cognitive processes result from underlying cellular and molecular changes, genomics and transcriptomics assays have been applied to human and animal models to understand such events. Nevertheless, genes and RNAs are not the end products of most biological functions. In order to gain further insights toward the understanding of brain processes, the field of proteomics has been of increasing importance in the past years. Advancements in liquid chromatography-tandem mass spectrometry (LC-MS/MS) have enabled the identification and quantification of thousands of proteins with high accuracy and sensitivity, fostering a revolution in the neurosciences. Herein, we review the molecular bases of explicit memory in the hippocampus. We outline the principles of mass spectrometry (MS)-based proteomics, highlighting the use of this analytical tool to study memory formation. In addition, we discuss MS-based targeted approaches as the future of protein analysis. PMID:27790611

  5. A Proteogenomic Approach to Understanding MYC Function in Metastatic Medulloblastoma Tumors

    Science.gov (United States)

    Staal, Jerome A.; Pei, Yanxin; Rood, Brian R.

    2016-01-01

    Brain tumors are the leading cause of cancer-related deaths in children, and medulloblastoma is the most prevalent malignant childhood/pediatric brain tumor. Providing effective treatment for these cancers, with minimal damage to the still-developing brain, remains one of the greatest challenges faced by clinicians. Understanding the diverse events driving tumor formation, maintenance, progression, and recurrence is necessary for identifying novel targeted therapeutics and improving survival of patients with this disease. Genomic copy number alteration data, together with clinical studies, identifies c-MYC amplification as an important risk factor associated with the most aggressive forms of medulloblastoma with marked metastatic potential. Yet despite this, very little is known regarding the impact of such genomic abnormalities upon the functional biology of the tumor cell. We discuss here how recent advances in quantitative proteomic techniques are now providing new insights into the functional biology of these aggressive tumors, as illustrated by the use of proteomics to bridge the gap between the genotype and phenotype in the case of c-MYC-amplified/associated medulloblastoma. These integrated proteogenomic approaches now provide a new platform for understanding cancer biology by providing a functional context to frame genomic abnormalities. PMID:27775567

  6. A community-based systems learning approach to understanding youth violence in Boston.

    Science.gov (United States)

    Bridgewater, Khary; Peterson, Steve; McDevitt, John; Hemenway, David; Bass, Jeffrey; Bothwell, Paul; Everdell, Ros

    2011-01-01

    Youth violence in general and gang violence in particular continues to be a pernicious problem facing the majority of large U.S. cities. Attempts to reduce youth violence are hindered by the absence of a shared framework that crosses multiple disciplines. The goal of the Youth Violence Systems Project (YVSP) is to help communities strategize for and achieve sustained reductions in youth violence in Boston. A distinction of YVSP is the engagement of community residents in a group model building process to develop a conceptual framework and create a system dynamics computer model of youth violence in Boston. Community residents including youth participated in the design, execution, and evaluation of the project. We also partnered with community agencies to gain insight from individuals with a history of gang involvement or violent offense. The computer model highlights the dynamics of movement into and out of gangs, and the relationships that influence violent interactions among individuals and gangs. The model serves as a simulation-based laboratory for examining initiatives aimed at reducing youth violence within a community. It considers the positive feedback between traumatic stress and violence; as violence levels rise in the community, this increases individual traumatic stress, which further increases violent responses by community members. The project's community-based approach coupled with its system dynamics methodology produced a new understanding of youth violence in Boston. This understanding undergirds the model's logic, making it more useful to community residents and more accurate in describing the behavior of youth in high-violence neighborhoods.

  7. CEOS Theory: A Comprehensive Approach to Understanding Hard to Maintain Behaviour Change.

    Science.gov (United States)

    Borland, Ron

    2017-03-01

    This paper provides a brief introduction to CEOS theory, a comprehensive theory for understanding hard to maintain behaviour change. The name CEOS is an acronym for Context, Executive, and Operational Systems theory. Behaviour is theorised to be the result of the moment by moment interaction between internal needs (operational processes) in relation to environmental conditions, and for humans this is augmented by goal-directed, executive action which can transcend immediate contingencies. All behaviour is generated by operational processes. Goal-directed behaviours only triumph over contingency-generated competing behaviours when operational processes have been sufficiently activated to support them. Affective force can be generated around executive system (ES) goals from such things as memories of direct experience, vicarious experience, and emotionally charged communications mediated through stories the person generates. This paper makes some refinements and elaborations of the theory, particularly around the role of feelings, and of the importance of stories and scripts for facilitating executive action. It also sketches out how it reconceptualises a range of issues relevant to behaviour change. CEOS provides a framework for understanding the limitations of both informational and environmental approaches to behaviour change, the need for self-regulatory strategies and for taking into account more basic aspects of human functioning. © 2016 The Authors. Applied Psychology: Health and Well-Being published by John Wiley & Sons Ltd on behalf of International Association of Applied Psychology.

  8. Human Activity-Understanding: A Multilayer Approach Combining Body Movements and Contextual Descriptors Analysis

    Directory of Open Access Journals (Sweden)

    Consuelo Granata

    2015-07-01

    Full Text Available A deep understanding of human activity is key to successful human-robot interaction (HRI. The translation of sensed human behavioural signals/cues and context descriptors into an encoded human activity remains a challenge because of the complex nature of human actions. In this paper, we propose a multilayer framework for the understanding of human activity to be implemented in a mobile robot. It consists of a perception layer which exploits a D-RGB-based skeleton tracking output used to simulate a physical model of virtual human dynamics in order to compensate for the inaccuracy and inconsistency of the raw data. A multi-support vector machine (MSVM model trained with features describing the human motor coordination through temporal segments in combination with environment descriptors (object affordance is used to recognize each sub-activity (classification layer. The interpretation of sequences of classified elementary actions is based on discrete hidden Markov models (DHMMs (interpretation layer. The framework assessment was performed on the Cornell Activity Dataset (CAD-120 [1]. The performances of our method are comparable with those presented in [2] and clearly show the relevance of this model-based approach.

  9. A Proteogenomic Approach to Understanding MYC Function in Metastatic Medulloblastoma Tumors

    Directory of Open Access Journals (Sweden)

    Jerome A. Staal

    2016-10-01

    Full Text Available Brain tumors are the leading cause of cancer-related deaths in children, and medulloblastoma is the most prevalent malignant childhood/pediatric brain tumor. Providing effective treatment for these cancers, with minimal damage to the still-developing brain, remains one of the greatest challenges faced by clinicians. Understanding the diverse events driving tumor formation, maintenance, progression, and recurrence is necessary for identifying novel targeted therapeutics and improving survival of patients with this disease. Genomic copy number alteration data, together with clinical studies, identifies c-MYC amplification as an important risk factor associated with the most aggressive forms of medulloblastoma with marked metastatic potential. Yet despite this, very little is known regarding the impact of such genomic abnormalities upon the functional biology of the tumor cell. We discuss here how recent advances in quantitative proteomic techniques are now providing new insights into the functional biology of these aggressive tumors, as illustrated by the use of proteomics to bridge the gap between the genotype and phenotype in the case of c-MYC-amplified/associated medulloblastoma. These integrated proteogenomic approaches now provide a new platform for understanding cancer biology by providing a functional context to frame genomic abnormalities.

  10. Mass Spectrometry-based Approaches to Understand the Molecular Basis of Memory

    Directory of Open Access Journals (Sweden)

    Arthur Henriques Pontes

    2016-10-01

    Full Text Available The central nervous system is responsible for an array of cognitive functions such as memory, learning, language and attention. These processes tend to take place in distinct brain regions; yet, they need to be integrated to give rise to adaptive or meaningful behavior. Since cognitive processes result from underlying cellular and molecular changes, genomics and transcriptomics assays have been applied to human and animal models to understand such events. Nevertheless, genes and RNAs are not the end products of most biological functions. In order to gain further insights toward the understanding of brain processes, the field of proteomics has been of increasing importance in the past years. Advancements in liquid chromatography-tandem mass spectrometry (LC-MS/MS have enable the identification and quantification of thousand of proteins with high accuracy and sensitivity, fostering a revolution in the neurosciences. Herein, we review the molecular bases of explicit memory in the hippocampus. We outline the principles of mass spectrometry (MS-based proteomics, highlighting the use of this analytical tool to study memory formation. In addition, we discuss MS-based targeted approaches as the future of protein analysis.

  11. Mass Spectrometry-based Approaches to Understand the Molecular Basis of Memory

    Science.gov (United States)

    Pontes, Arthur; de Sousa, Marcelo

    2016-10-01

    The central nervous system is responsible for an array of cognitive functions such as memory, learning, language and attention. These processes tend to take place in distinct brain regions; yet, they need to be integrated to give rise to adaptive or meaningful behavior. Since cognitive processes result from underlying cellular and molecular changes, genomics and transcriptomics assays have been applied to human and animal models to understand such events. Nevertheless, genes and RNAs are not the end products of most biological functions. In order to gain further insights toward the understanding of brain processes, the field of proteomics has been of increasing importance in the past years. Advancements in liquid chromatography-tandem mass spectrometry (LC-MS/MS) have enable the identification and quantification of thousand of proteins with high accuracy and sensitivity, fostering a revolution in the neurosciences. Herein, we review the molecular bases of explicit memory in the hippocampus. We outline the principles of mass spectrometry (MS)-based proteomics, highlighting the use of this analytical tool to study memory formation. In addition, we discuss MS-based targeted approaches as the future of protein analysis.

  12. Toward understanding Malaysian fishermen's decision making on the use of fishing technology: a mental model approach.

    Science.gov (United States)

    Hamzah, Azimi; Krauss, Steven E; Shaffril, Hayrol A M; Suandi, Turiman; Ismail, Ismi A; Abu Samah, Bahaman

    2014-10-01

    The vast majority of Malaysia's fishermen are located in rural areas, specifically in the Western and Eastern coastal regions of Peninsular Malaysia and the Sabah and Sarawak central zones. In these areas, the fishing industry is relied upon as a major economic contributor to the region's residents. Despite the widespread application of various modern technologies into the fishing industry (i.e., GPS, sonar, echo sounder, remote sensing), and the Malaysian government's efforts to encourage their adoption, many small-scale fishermen in the country's rural areas continue to rely on traditional fishing methods. This refusal to embrace new technologies has resulted in significant losses in fish yields and needed income, and has raised many questions regarding the inputs to decision making of the fishermen. Drawing on multiple literatures, in this article we argue for the use of a mental model approach to gain an in-depth understanding of rural Malaysian fishermen's choices of technology adoption according to four main constructs--prior experience, knowledge, expertise and beliefs or values. To provide needed inputs to agricultural specialists and related policy makers for the development of relevant plans of action, this article aims to provide a way forward for others to understand dispositional barriers to technology adoption among fishermen who use traditional methods in non-Western contexts. © 2013 International Union of Psychological Science.

  13. Integrated Experimental and Computational Approach to Understand the Effects of Heavy Ion Radiation on Skin Homeostasis.

    Energy Technology Data Exchange (ETDEWEB)

    von Neubeck, Claere; Shankaran, Harish; Geniza, Matthew; Kauer, Paula M.; Robinson, Robert J.; Chrisler, William B.; Sowa, Marianne B.

    2013-08-08

    The effects of low dose high linear energy transfer (LET) radiation on human health are of concern for both space and clinical exposures. As epidemiological data for such radiation exposures are scarce for making relevant predictions, we need to understand the mechanism of response especially in normal tissues. Our objective here is to understand the effects of heavy ion radiation on tissue homeostasis in a realistic model system. Towards this end, we exposed an in vitro three dimensional skin equivalent to low fluences of Neon (Ne) ions (300 MeV/u), and determined the differentiation profile as a function of time following exposure using immunohistochemistry. We found that Ne ion exposures resulted in transient increases in the tissue regions expressing the differentiation markers keratin 10, and filaggrin, and more subtle time-dependent effects on the number of basal cells in the epidermis. We analyzed the data using a mathematical model of the skin equivalent, to quantify the effect of radiation on cell proliferation and differentiation. The agent-based mathematical model for the epidermal layer treats the epidermis as a collection of heterogeneous cell types with different proliferation/differentiation properties. We obtained model parameters from the literature where available, and calibrated the unknown parameters to match the observed properties in unirradiated skin. We then used the model to rigorously examine alternate hypotheses regarding the effects of high LET radiation on the tissue. Our analysis indicates that Ne ion exposures induce rapid, but transient, changes in cell division, differentiation and proliferation. We have validated the modeling results by histology and quantitative reverse transcription polymerase chain reaction (qRT-PCR). The integrated approach presented here can be used as a general framework to understand the responses of multicellular systems, and can be adapted to other epithelial tissues.

  14. Improving our understanding, and detection, of glaucomatous damage: An approach based upon optical coherence tomography (OCT)

    Science.gov (United States)

    Hood, Donald C.

    2017-01-01

    Although ophthalmologists are becoming increasingly reliant upon optical coherence tomography (OCT), clinicians who care for glaucoma patients are not taking full advantage of the potential of this powerful technology. First, we ask, how would one describe the nature of glaucomatous damage if only OCT scans were available? In particular, a schematic model of glaucomatous damage is developed in section 2, and the nature of glaucomatous damage seen on OCT scans described in the context of this model in section 3. In particular, we illustrate that local thinning of the circumpapillary retinal nerve fiber layer (cpRNFL) around the optic disc can vary in location, depth, and/or width, as well as homogeneity of damage. Second, we seek to better understand the relationship between the thinning of the cpRNFL and the various patterns of sensitivity loss seen on visual fields obtained with standard automated perimetry. In sections 4 and 5, we illustrate why one should expect a wide range of visual field patterns, and iilustrate why they should not be placed into discrete categories. Finally, section 6 describes how the clinician can take better advantage of the information in OCT scans. The approach is summarized in a single-page report, which can be generated from a single wide-field scan. The superiority of this approach, as opposed to the typical reliance on summary metrics, is described. PMID:28012881

  15. Understanding and Improving Recruitment to Randomised Controlled Trials: Qualitative Research Approaches.

    Science.gov (United States)

    Elliott, Daisy; Husbands, Samantha; Hamdy, Freddie C; Holmberg, Lars; Donovan, Jenny L

    2017-11-01

    The importance of evidence from randomised trials is now widely recognised, although recruitment is often difficult. Qualitative research has shown promise in identifying the key barriers to recruitment, and interventions have been developed to reduce organisational difficulties and support clinicians undertaking recruitment. This article provides an introduction to qualitative research techniques and explains how this approach can be used to understand-and subsequently improve-recruitment and informed consent within a range of clinical trials. A literature search was performed using Medline, Embase, and CINAHL. All studies with qualitative research methods that focused on the recruitment activity of clinicians were included in the review. The majority of studies reported that organisational difficulties and lack of time for clinical staff were key barriers to recruitment. However, a synthesis of qualitative studies highlighted the intellectual and emotional challenges that arise when combining research with clinical roles, particularly in relation to equipoise and patient eligibility. To support recruiters to become more comfortable with the design and principles of randomised controlled trials, interventions have been developed, including the QuinteT Recruitment Intervention, which comprises in-depth investigation of recruitment obstacles in real time, followed by implementation of tailored strategies to address these challenges as the trial proceeds. Qualitative research can provide important insights into the complexities of recruitment to trials and inform the development of interventions, and provide support and training initiatives as required. Investigators should consider implementing such methods in trials expected to be challenging or recruiting below target. Qualitative research is a term used to describe a range of methods that can be implemented to understand participants' perspectives and behaviours. Data are gathered from interviews, focus groups

  16. The Value of a Comparative Approach to Understand the Complex Interplay between Microbiota and Host Immunity.

    Science.gov (United States)

    Morella, Norma M; Koskella, Britt

    2017-01-01

    The eukaryote immune system evolved and continues to evolve within a microbial world, and as such is critically shaped by-and in some cases even reliant upon-the presence of host-associated microbial species. There are clear examples of adaptations that allow the host to simultaneously tolerate and/or promote growth of symbiotic microbiota while protecting itself against pathogens, but the relationship between immunity and the microbiome reaches far beyond simple recognition and includes complex cross talk between host and microbe as well as direct microbiome-mediated protection against pathogens. Here, we present a broad but brief overview of how the microbiome is controlled by and interacts with diverse immune systems, with the goal of identifying questions that can be better addressed by taking a comparative approach across plants and animals and different types of immunity. As two key examples of such an approach, we focus on data examining the importance of early exposure on microbiome tolerance and immune system development and function, and the importance of transmission among hosts in shaping the potential coevolution between, and long-term stability of, host-microbiome associations. Then, by comparing existing evidence across short-lived plants, mouse model systems and humans, and insects, we highlight areas of microbiome research that are strong in some systems and absent in others with the hope of guiding future research that will allow for broad-scale comparisons moving forward. We argue that such an approach will not only help with identification of generalities in host-microbiome-immune interactions but also improve our understanding of the role of the microbiome in host health.

  17. The Value of a Comparative Approach to Understand the Complex Interplay between Microbiota and Host Immunity

    Directory of Open Access Journals (Sweden)

    Norma M. Morella

    2017-09-01

    Full Text Available The eukaryote immune system evolved and continues to evolve within a microbial world, and as such is critically shaped by—and in some cases even reliant upon—the presence of host-associated microbial species. There are clear examples of adaptations that allow the host to simultaneously tolerate and/or promote growth of symbiotic microbiota while protecting itself against pathogens, but the relationship between immunity and the microbiome reaches far beyond simple recognition and includes complex cross talk between host and microbe as well as direct microbiome-mediated protection against pathogens. Here, we present a broad but brief overview of how the microbiome is controlled by and interacts with diverse immune systems, with the goal of identifying questions that can be better addressed by taking a comparative approach across plants and animals and different types of immunity. As two key examples of such an approach, we focus on data examining the importance of early exposure on microbiome tolerance and immune system development and function, and the importance of transmission among hosts in shaping the potential coevolution between, and long-term stability of, host–microbiome associations. Then, by comparing existing evidence across short-lived plants, mouse model systems and humans, and insects, we highlight areas of microbiome research that are strong in some systems and absent in others with the hope of guiding future research that will allow for broad-scale comparisons moving forward. We argue that such an approach will not only help with identification of generalities in host–microbiome–immune interactions but also improve our understanding of the role of the microbiome in host health.

  18. Understanding uncertainty in temperature effects on vector-borne disease: a Bayesian approach.

    Science.gov (United States)

    Johnson, Leah R; Ben-Horin, Tal; Lafferty, Kevin D; McNally, Amy; Mordecai, Erin; Paaijmans, Krijn P; Pawar, Samraat; Ryan, Sadie J

    2015-01-01

    Extrinsic environmental factors influence the distribution and population dynamics of many organisms, including insects that are of concern for human health and agriculture. This is particularly true for vector-borne infectious diseases like malaria, which is a major source of morbidity and mortality in humans. Understanding the mechanistic links between environment and population processes for these diseases is key to predicting the consequences of climate change on transmission and for developing effective interventions. An important measure of the intensity of disease transmission is the reproductive number R0. However, understanding the mechanisms linking R0 and temperature, an environmental factor driving disease risk, can be challenging because the data available for parameterization are often poor. To address this, we show how a Bayesian approach can help identify critical uncertainties in components of R0 and how this uncertainty is propagated into the estimate of R0. Most notably, we find that different parameters dominate the uncertainty at different temperature regimes: bite rate from 15 degrees C to 25 degrees C; fecundity across all temperatures, but especially approximately 25-32 degrees C; mortality from 20 degrees C to 30 degrees C; parasite development rate at degrees 15-16 degrees C and again at approximately 33-35 degrees C. Focusing empirical studies on these parameters and corresponding temperature ranges would be the most efficient way to improve estimates of R0. While we focus on malaria, our methods apply to improving process-based models more generally, including epidemiological, physiological niche, and species distribution models.

  19. Understanding uncertainty in temperature effects on vector-borne disease: a Bayesian approach

    Science.gov (United States)

    Johnson, Leah R.; Ben-Horin, Tal; Lafferty, Kevin D.; McNally, Amy; Mordecai, Erin A.; Paaijmans, Krijn P.; Pawar, Samraat; Ryan, Sadie J.

    2015-01-01

    Extrinsic environmental factors influence the distribution and population dynamics of many organisms, including insects that are of concern for human health and agriculture. This is particularly true for vector-borne infectious diseases like malaria, which is a major source of morbidity and mortality in humans. Understanding the mechanistic links between environment and population processes for these diseases is key to predicting the consequences of climate change on transmission and for developing effective interventions. An important measure of the intensity of disease transmission is the reproductive number R0. However, understanding the mechanisms linking R0 and temperature, an environmental factor driving disease risk, can be challenging because the data available for parameterization are often poor. To address this, we show how a Bayesian approach can help identify critical uncertainties in components of R0 and how this uncertainty is propagated into the estimate of R0. Most notably, we find that different parameters dominate the uncertainty at different temperature regimes: bite rate from 15°C to 25°C; fecundity across all temperatures, but especially ~25–32°C; mortality from 20°C to 30°C; parasite development rate at ~15–16°C and again at ~33–35°C. Focusing empirical studies on these parameters and corresponding temperature ranges would be the most efficient way to improve estimates of R0. While we focus on malaria, our methods apply to improving process-based models more generally, including epidemiological, physiological niche, and species distribution models.

  20. From Process Understanding Via Soil Functions to Sustainable Soil Management - A Systemic Approach

    Science.gov (United States)

    Wollschlaeger, U.; Bartke, S.; Bartkowski, B.; Daedlow, K.; Helming, K.; Kogel-Knabner, I.; Lang, B.; Rabot, E.; Russell, D.; Stößel, B.; Weller, U.; Wiesmeier, M.; Rabot, E.; Vogel, H. J.

    2017-12-01

    Fertile soils are central resources for the production of biomass and the provision of food and energy. A growing world population and latest climate targets lead to an increasing demand for both, food and bio-energy, which requires preserving and improving the long-term productivity of soils as a bio-economic resource. At the same time, other soil functions and ecosystem services need to be maintained: filter for clean water, carbon sequestration, provision and recycling of nutrients, and habitat for biological activity. All these soil functions result from the interaction of a multitude of physical, chemical and biological processes that are not yet sufficiently understood. In addition, we lack understanding about the interplay between the socio-economic system and the soil system and how soil functions benefit human wellbeing. Hence, a solid and integrated assessment of soil quality requires the consideration of the ensemble of soil functions and its relation to soil management to finally be able to develop site-specific options for sustainable soil management. We present an integrated modeling approach that investigates the influence of soil management on the ensemble of soil functions. It is based on the mechanistic relationships between soil functional attributes, each explained by a network of interacting processes as derived from scientific evidence. As the evidence base required for feeding the model is for the most part stored in the existing scientific literature, another central component of our work is to set up a public "knowledge-portal" providing the infrastructure for a community effort towards a comprehensive knowledge base on soil processes as a basis for model developments. The connection to the socio-economic system is established using the Drivers-Pressures-Impacts-States-Responses (DPSIR) framework where our improved understanding about soil ecosystem processes is linked to ecosystem services and resource efficiency via the soil functions.

  1. A network biology approach to understanding the importance of chameleon proteins in human physiology and pathology.

    Science.gov (United States)

    Bahramali, Golnaz; Goliaei, Bahram; Minuchehr, Zarrin; Marashi, Sayed-Amir

    2017-02-01

    Chameleon proteins are proteins which include sequences that can adopt α-helix-β-strand (HE-chameleon) or α-helix-coil (HC-chameleon) or β-strand-coil (CE-chameleon) structures to operate their crucial biological functions. In this study, using a network-based approach, we examined the chameleon proteins to give a better knowledge on these proteins. We focused on proteins with identical chameleon sequences with more than or equal to seven residues long in different PDB entries, which adopt HE-chameleon, HC-chameleon, and CE-chameleon structures in the same protein. One hundred and ninety-one human chameleon proteins were identified via our in-house program. Then, protein-protein interaction (PPI) networks, Gene ontology (GO) enrichment, disease network, and pathway enrichment analyses were performed for our derived data set. We discovered that there are chameleon sequences which reside in protein-protein interaction regions between two proteins critical for their dual function. Analysis of the PPI networks for chameleon proteins introduced five hub proteins, namely TP53, EGFR, HSP90AA1, PPARA, and HIF1A, which were presented in four PPI clusters. The outcomes demonstrate that the chameleon regions are in critical domains of these proteins and are important in the development and treatment of human cancers. The present report is the first network-based functional study of chameleon proteins using computational approaches and might provide a new perspective for understanding the mechanisms of diseases helping us in developing new medical therapies along with discovering new proteins with chameleon properties which are highly important in cancer.

  2. A Geovisual Analytic Approach to Understanding Geo-Social Relationships in the International Trade Network

    Science.gov (United States)

    Luo, Wei; Yin, Peifeng; Di, Qian; Hardisty, Frank; MacEachren, Alan M.

    2014-01-01

    The world has become a complex set of geo-social systems interconnected by networks, including transportation networks, telecommunications, and the internet. Understanding the interactions between spatial and social relationships within such geo-social systems is a challenge. This research aims to address this challenge through the framework of geovisual analytics. We present the GeoSocialApp which implements traditional network analysis methods in the context of explicitly spatial and social representations. We then apply it to an exploration of international trade networks in terms of the complex interactions between spatial and social relationships. This exploration using the GeoSocialApp helps us develop a two-part hypothesis: international trade network clusters with structural equivalence are strongly ‘balkanized’ (fragmented) according to the geography of trading partners, and the geographical distance weighted by population within each network cluster has a positive relationship with the development level of countries. In addition to demonstrating the potential of visual analytics to provide insight concerning complex geo-social relationships at a global scale, the research also addresses the challenge of validating insights derived through interactive geovisual analytics. We develop two indicators to quantify the observed patterns, and then use a Monte-Carlo approach to support the hypothesis developed above. PMID:24558409

  3. A Visual Analytics Approach for Detecting and Understanding Anomalous Resident Behaviors in Smart Healthcare

    Directory of Open Access Journals (Sweden)

    Zhifang Liao

    2017-03-01

    Full Text Available With the development of science and technology, it is possible to analyze residents’ daily behaviors for the purpose of smart healthcare in the smart home environment. Many researchers have begun to detect residents’ anomalous behaviors and assess their physical condition, but these approaches used by the researchers are often caught in plight caused by a lack of ground truth, one-sided analysis of behavior, and difficulty of understanding behaviors. In this paper, we put forward a smart home visual analysis system (SHVis to help analysts detect and comprehend unusual behaviors of residents, and predict the health information intelligently. Firstly, the system classifies daily activities recorded by sensor devices in smart home environment into different categories, and discovers unusual behavior patterns of residents living in this environment by using various characteristics extracted from those activities and appropriate unsupervised anomaly detection algorithm. Secondly, on the basis of figuring out the residents’ anomaly degree of every date, we explore the daily behavior patterns and details with the help of several visualization views, and compare and analyze residents’ activities of various dates to find the reasons why residents act unusually. In the case study of this paper, we analyze residents’ behaviors that happened over two months and find unusual indoor behaviors and give health advice to the residents.

  4. Creating the brain and interacting with the brain: an integrated approach to understanding the brain

    Science.gov (United States)

    Morimoto, Jun; Kawato, Mitsuo

    2015-01-01

    In the past two decades, brain science and robotics have made gigantic advances in their own fields, and their interactions have generated several interdisciplinary research fields. First, in the ‘understanding the brain by creating the brain’ approach, computational neuroscience models have been applied to many robotics problems. Second, such brain-motivated fields as cognitive robotics and developmental robotics have emerged as interdisciplinary areas among robotics, neuroscience and cognitive science with special emphasis on humanoid robots. Third, in brain–machine interface research, a brain and a robot are mutually connected within a closed loop. In this paper, we review the theoretical backgrounds of these three interdisciplinary fields and their recent progress. Then, we introduce recent efforts to reintegrate these research fields into a coherent perspective and propose a new direction that integrates brain science and robotics where the decoding of information from the brain, robot control based on the decoded information and multimodal feedback to the brain from the robot are carried out in real time and in a closed loop. PMID:25589568

  5. A structural equation modeling approach to understanding pathways that connect socioeconomic status and smoking.

    Science.gov (United States)

    Martinez, Sydney A; Beebe, Laura A; Thompson, David M; Wagener, Theodore L; Terrell, Deirdra R; Campbell, Janis E

    2018-01-01

    The inverse association between socioeconomic status and smoking is well established, yet the mechanisms that drive this relationship are unclear. We developed and tested four theoretical models of the pathways that link socioeconomic status to current smoking prevalence using a structural equation modeling (SEM) approach. Using data from the 2013 National Health Interview Survey, we selected four indicator variables (poverty ratio, personal earnings, educational attainment, and employment status) that we hypothesize underlie a latent variable, socioeconomic status. We measured direct, indirect, and total effects of socioeconomic status on smoking on four pathways through four latent variables representing social cohesion, financial strain, sleep disturbance, and psychological distress. Results of the model indicated that the probability of being a smoker decreased by 26% of a standard deviation for every one standard deviation increase in socioeconomic status. The direct effects of socioeconomic status on smoking accounted for the majority of the total effects, but the overall model also included significant indirect effects. Of the four mediators, sleep disturbance and psychological distress had the largest total effects on current smoking. We explored the use of structural equation modeling in epidemiology to quantify effects of socioeconomic status on smoking through four social and psychological factors to identify potential targets for interventions. A better understanding of the complex relationship between socioeconomic status and smoking is critical as we continue to reduce the burden of tobacco and eliminate health disparities related to smoking.

  6. Discovering and understanding oncogenic gene fusions through data intensive computational approaches

    Science.gov (United States)

    Latysheva, Natasha S.; Babu, M. Madan

    2016-01-01

    Abstract Although gene fusions have been recognized as important drivers of cancer for decades, our understanding of the prevalence and function of gene fusions has been revolutionized by the rise of next-generation sequencing, advances in bioinformatics theory and an increasing capacity for large-scale computational biology. The computational work on gene fusions has been vastly diverse, and the present state of the literature is fragmented. It will be fruitful to merge three camps of gene fusion bioinformatics that appear to rarely cross over: (i) data-intensive computational work characterizing the molecular biology of gene fusions; (ii) development research on fusion detection tools, candidate fusion prioritization algorithms and dedicated fusion databases and (iii) clinical research that seeks to either therapeutically target fusion transcripts and proteins or leverages advances in detection tools to perform large-scale surveys of gene fusion landscapes in specific cancer types. In this review, we unify these different—yet highly complementary and symbiotic—approaches with the view that increased synergy will catalyze advancements in gene fusion identification, characterization and significance evaluation. PMID:27105842

  7. A geovisual analytic approach to understanding geo-social relationships in the international trade network.

    Science.gov (United States)

    Luo, Wei; Yin, Peifeng; Di, Qian; Hardisty, Frank; MacEachren, Alan M

    2014-01-01

    The world has become a complex set of geo-social systems interconnected by networks, including transportation networks, telecommunications, and the internet. Understanding the interactions between spatial and social relationships within such geo-social systems is a challenge. This research aims to address this challenge through the framework of geovisual analytics. We present the GeoSocialApp which implements traditional network analysis methods in the context of explicitly spatial and social representations. We then apply it to an exploration of international trade networks in terms of the complex interactions between spatial and social relationships. This exploration using the GeoSocialApp helps us develop a two-part hypothesis: international trade network clusters with structural equivalence are strongly 'balkanized' (fragmented) according to the geography of trading partners, and the geographical distance weighted by population within each network cluster has a positive relationship with the development level of countries. In addition to demonstrating the potential of visual analytics to provide insight concerning complex geo-social relationships at a global scale, the research also addresses the challenge of validating insights derived through interactive geovisual analytics. We develop two indicators to quantify the observed patterns, and then use a Monte-Carlo approach to support the hypothesis developed above.

  8. Gait and Cognition: A Complementary Approach to Understanding Brain Function and the Risk of Falling

    Science.gov (United States)

    Montero-Odasso, Manuel; Verghese, Joe; Beauchet, Olivier; Hausdorff, Jeffrey M.

    2012-01-01

    Until recently, clinicians and researchers have performed gait assessments and cognitive assessments separately when evaluating older adults. Increasing evidence from clinical practice, epidemiological studies, and clinical trials shows that gait and cognition are inter-related in older adults. Quantifiable alterations in gait among older adults are associated with falls, dementia, and disability. At the same time, emerging evidence indicates that early disturbances in cognitive processes such as attention, executive function, and working memory are associated with slower gait and gait instability during single and dual-task testing, and that these cognitive disturbances assist in the prediction of future mobility loss, falls, and progression to dementia. This paper reviews the importance of the gait-cognition inter-relationship in aging and presents evidence that gait assessments can provide a window into the understanding of cognitive function and dysfunctions, and fall risk in older people in clinical practice. To this end, the benefits of dual-task gait assessments (e.g., walking while performing an attention-demanding task) as a marker of fall risk are summarized. Further, we also present a potential complementary approach for reducing the risk of falls by improving certain aspects of cognition through both non-pharmacological and pharmacological treatments. Untangling the relationship between early gait disturbances and early cognitive changes may be helpful for identifying older adults at higher risk of experiencing mobility decline, falls and the progression to dementia. PMID:23110433

  9. Data-based perfect-deficit approach to understanding climate extremes and forest carbon assimilation capacity

    Science.gov (United States)

    Wei, Suhua; Yi, Chuixiang; Hendrey, George; Eaton, Timothy; Rustic, Gerald; Wang, Shaoqiang; Liu, Heping; Krakauer, Nir Y.; Wang, Weiguo; Desai, Ankur R.; Montagnani, Leonardo; Tha Paw U, Kyaw; Falk, Matthias; Black, Andrew; Bernhofer, Christian; Grünwald, Thomas; Laurila, Tuomas; Cescatti, Alessandro; Moors, Eddy; Bracho, Rosvel; Valentini, Riccardo

    2014-05-01

    Several lines of evidence suggest that the warming climate plays a vital role in driving certain types of extreme weather. The impact of warming and of extreme weather on forest carbon assimilation capacity is poorly known. Filling this knowledge gap is critical towards understanding the amount of carbon that forests can hold. Here, we used a perfect-deficit approach to identify forest canopy photosynthetic capacity (CPC) deficits and analyze how they correlate to climate extremes, based on observational data measured by the eddy covariance method at 27 forest sites over 146 site-years. We found that droughts severely affect the carbon assimilation capacities of evergreen broadleaf forest (EBF) and deciduous broadleaf forest. The carbon assimilation capacities of Mediterranean forests were highly sensitive to climate extremes, while marine forest climates tended to be insensitive to climate extremes. Our estimates suggest an average global reduction of forest CPC due to unfavorable climate extremes of 6.3 Pg C (˜5.2% of global gross primary production) per growing season over 2001-2010, with EBFs contributing 52% of the total reduction.

  10. A structural equation modeling approach to understanding pathways that connect socioeconomic status and smoking.

    Directory of Open Access Journals (Sweden)

    Sydney A Martinez

    Full Text Available The inverse association between socioeconomic status and smoking is well established, yet the mechanisms that drive this relationship are unclear. We developed and tested four theoretical models of the pathways that link socioeconomic status to current smoking prevalence using a structural equation modeling (SEM approach. Using data from the 2013 National Health Interview Survey, we selected four indicator variables (poverty ratio, personal earnings, educational attainment, and employment status that we hypothesize underlie a latent variable, socioeconomic status. We measured direct, indirect, and total effects of socioeconomic status on smoking on four pathways through four latent variables representing social cohesion, financial strain, sleep disturbance, and psychological distress. Results of the model indicated that the probability of being a smoker decreased by 26% of a standard deviation for every one standard deviation increase in socioeconomic status. The direct effects of socioeconomic status on smoking accounted for the majority of the total effects, but the overall model also included significant indirect effects. Of the four mediators, sleep disturbance and psychological distress had the largest total effects on current smoking. We explored the use of structural equation modeling in epidemiology to quantify effects of socioeconomic status on smoking through four social and psychological factors to identify potential targets for interventions. A better understanding of the complex relationship between socioeconomic status and smoking is critical as we continue to reduce the burden of tobacco and eliminate health disparities related to smoking.

  11. Creating the brain and interacting with the brain: an integrated approach to understanding the brain.

    Science.gov (United States)

    Morimoto, Jun; Kawato, Mitsuo

    2015-03-06

    In the past two decades, brain science and robotics have made gigantic advances in their own fields, and their interactions have generated several interdisciplinary research fields. First, in the 'understanding the brain by creating the brain' approach, computational neuroscience models have been applied to many robotics problems. Second, such brain-motivated fields as cognitive robotics and developmental robotics have emerged as interdisciplinary areas among robotics, neuroscience and cognitive science with special emphasis on humanoid robots. Third, in brain-machine interface research, a brain and a robot are mutually connected within a closed loop. In this paper, we review the theoretical backgrounds of these three interdisciplinary fields and their recent progress. Then, we introduce recent efforts to reintegrate these research fields into a coherent perspective and propose a new direction that integrates brain science and robotics where the decoding of information from the brain, robot control based on the decoded information and multimodal feedback to the brain from the robot are carried out in real time and in a closed loop. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  12. Understanding the Complexities of Food Safety Using a "One Health" Approach.

    Science.gov (United States)

    Kniel, Kalmia E; Kumar, Deepak; Thakur, Siddhartha

    2018-02-01

    The philosophy of One Health is growing in concept and clarity. The interdependence of human, animal, and environmental health is the basis for the concept of One Health. One Health is a comprehensive approach to ensure the health of people, animals, and the environment through collaborative efforts. Preharvest food safety issues align with the grand concept of One Health. Imagine any food production system, and immediately, parallel images from One Health emerge: for example, transmission of zoonotic diseases, antibiotic residues, or resistance genes in the environment; environmental and animal host reservoirs of disease; challenges with rearing animals and growing fresh produce on the same farm; application and transport of manure or diseased animals. During a recent celebration of #OneHealthDay, information was shared around the globe concerning scientists dedicated to One Health research systems. An ever-growing trade and global commerce system mixed with our incessant desire for food products during the whole year makes it all the more important to take a global view through the One Health lens to solve these growing challenges. The recent explosion of Zika virus around the globe renewed the need for assessing transmissible diseases through the eyes of One Health. It is not good enough to know how a disease affects the human population without a thorough understanding of the environment and vector reservoirs. If 60 to 75% of infectious diseases affecting humans are of animal origin, the need for better One Health research strategies and overdue solutions is imperative.

  13. Understanding Challenges in the Front Lines of Home Health Care: A Human-Systems Approach

    Science.gov (United States)

    Beer, Jenay M.; McBride, Sara E.; Mitzner, Tracy L.; Rogers, Wendy A.

    2014-01-01

    A human-systems perspective is a fruitful approach to understanding home health care because it emphasizes major individual components of the system – persons, equipment/technology, tasks, and environments –as well as the interaction between these components. The goal of this research was to apply a human-system perspective to consider the capabilities and limitations of the persons, in relation to the demands of the tasks and equipment/technology in home health care. Identification of challenges and mismatches between the person(s) capabilities and the demands of providing care provide guidance for human factors interventions. A qualitative study was conducted with 8 home health Certified Nursing Assistants and 8 home health Registered Nurses interviewed about challenges they encounter in their jobs. A systematic categorization of the challenges the care providers reported was conducted and human factors recommendations were proposed in response, to improve home health. The challenges inform a human-systems model of home health care. PMID:24958610

  14. Meta-Analysis of the Reasoned Action Approach (RAA) to Understanding Health Behaviors.

    Science.gov (United States)

    McEachan, Rosemary; Taylor, Natalie; Harrison, Reema; Lawton, Rebecca; Gardner, Peter; Conner, Mark

    2016-08-01

    Reasoned action approach (RAA) includes subcomponents of attitude (experiential/instrumental), perceived norm (injunctive/descriptive), and perceived behavioral control (capacity/autonomy) to predict intention and behavior. To provide a meta-analysis of the RAA for health behaviors focusing on comparing the pairs of RAA subcomponents and differences between health protection and health-risk behaviors. The present research reports a meta-analysis of correlational tests of RAA subcomponents, examination of moderators, and combined effects of subcomponents on intention and behavior. Regressions were used to predict intention and behavior based on data from studies measuring all variables. Capacity and experiential attitude had large, and other constructs had small-medium-sized correlations with intention; all constructs except autonomy were significant independent predictors of intention in regressions. Intention, capacity, and experiential attitude had medium-large, and other constructs had small-medium-sized correlations with behavior; intention, capacity, experiential attitude, and descriptive norm were significant independent predictors of behavior in regressions. The RAA subcomponents have utility in predicting and understanding health behaviors.

  15. Applying the reasoned action approach to understanding health protection and health risk behaviors.

    Science.gov (United States)

    Conner, Mark; McEachan, Rosemary; Lawton, Rebecca; Gardner, Peter

    2017-12-01

    The Reasoned Action Approach (RAA) developed out of the Theory of Reasoned Action and Theory of Planned Behavior but has not yet been widely applied to understanding health behaviors. The present research employed the RAA in a prospective design to test predictions of intention and action for groups of protection and risk behaviors separately in the same sample. To test the RAA for health protection and risk behaviors. Measures of RAA components plus past behavior were taken in relation to eight protection and six risk behaviors in 385 adults. Self-reported behavior was assessed one month later. Multi-level modelling showed instrumental attitude, experiential attitude, descriptive norms, capacity and past behavior were significant positive predictors of intentions to engage in protection or risk behaviors. Injunctive norms were only significant predictors of intention in protection behaviors. Autonomy was a significant positive predictor of intentions in protection behaviors and a negative predictor in risk behaviors (the latter relationship became non-significant when controlling for past behavior). Multi-level modelling showed that intention, capacity, and past behavior were significant positive predictors of action for both protection and risk behaviors. Experiential attitude and descriptive norm were additional significant positive predictors of risk behaviors. The RAA has utility in predicting both protection and risk health behaviors although the power of predictors may vary across these types of health behavior. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. An evolutionary medicine approach to understanding factors that contribute to chronic obstructive pulmonary disease.

    Science.gov (United States)

    Aoshiba, Kazutetsu; Tsuji, Takao; Itoh, Masayuki; Yamaguchi, Kazuhiro; Nakamura, Hiroyuki

    2015-01-01

    Although many studies have been published on the causes and mechanisms of chronic obstructive pulmonary disease (COPD), the reason for the existence of COPD and the reasons why COPD develops in humans have hardly been studied. Evolutionary medical approaches are required to explain not only the proximate factors, such as the causes and mechanisms of a disease, but the ultimate (evolutionary) factors as well, such as why the disease is present and why the disease develops in humans. According to the concepts of evolutionary medicine, disease susceptibility is acquired as a result of natural selection during the evolutionary process of traits linked to the genes involved in disease susceptibility. In this paper, we discuss the following six reasons why COPD develops in humans based on current evolutionary medical theories: (1) evolutionary constraints; (2) mismatch between environmental changes and evolution; (3) co-evolution with pathogenic microorganisms; (4) life history trade-off; (5) defenses and their costs, and (6) reproductive success at the expense of health. Our perspective pursues evolutionary answers to the fundamental question, 'Why are humans susceptible to this common disease, COPD, despite their long evolutionary history?' We believe that the perspectives offered by evolutionary medicine are essential for researchers to better understand the significance of their work.

  17. Gait and cognition: a complementary approach to understanding brain function and the risk of falling.

    Science.gov (United States)

    Montero-Odasso, Manuel; Verghese, Joe; Beauchet, Olivier; Hausdorff, Jeffrey M

    2012-11-01

    Until recently, clinicians and researchers have performed gait assessments and cognitive assessments separately when evaluating older adults, but increasing evidence from clinical practice, epidemiological studies, and clinical trials shows that gait and cognition are interrelated in older adults. Quantifiable alterations in gait in older adults are associated with falls, dementia, and disability. At the same time, emerging evidence indicates that early disturbances in cognitive processes such as attention, executive function, and working memory are associated with slower gait and gait instability during single- and dual-task testing and that these cognitive disturbances assist in the prediction of future mobility loss, falls, and progression to dementia. This article reviews the importance of the interrelationship between gait and cognition in aging and presents evidence that gait assessments can provide a window into the understanding of cognitive function and dysfunction and fall risk in older people in clinical practice. To this end, the benefits of dual-task gait assessments (e.g., walking while performing an attention-demanding task) as a marker of fall risk are summarized. A potential complementary approach for reducing the risk of falls by improving certain aspects of cognition through nonpharmacological and pharmacological treatments is also presented. Untangling the relationship between early gait disturbances and early cognitive changes may be helpful in identifying older adults at risk of experiencing mobility decline, falls, and progression to dementia. © 2012, Copyright the Authors Journal compilation © 2012, The American Geriatrics Society.

  18. Force-induced bone growth and adaptation: A system theoretical approach to understanding bone mechanotransduction

    International Nuclear Information System (INIS)

    Maldonado, Solvey; Findeisen, Rolf

    2010-01-01

    The modeling, analysis, and design of treatment therapies for bone disorders based on the paradigm of force-induced bone growth and adaptation is a challenging task. Mathematical models provide, in comparison to clinical, medical and biological approaches an structured alternative framework to understand the concurrent effects of the multiple factors involved in bone remodeling. By now, there are few mathematical models describing the appearing complex interactions. However, the resulting models are complex and difficult to analyze, due to the strong nonlinearities appearing in the equations, the wide range of variability of the states, and the uncertainties in parameters. In this work, we focus on analyzing the effects of changes in model structure and parameters/inputs variations on the overall steady state behavior using systems theoretical methods. Based on an briefly reviewed existing model that describes force-induced bone adaptation, the main objective of this work is to analyze the stationary behavior and to identify plausible treatment targets for remodeling related bone disorders. Identifying plausible targets can help in the development of optimal treatments combining both physical activity and drug-medication. Such treatments help to improve/maintain/restore bone strength, which deteriorates under bone disorder conditions, such as estrogen deficiency.

  19. Understanding Tremor in Multiple Sclerosis: Prevalence, Pathological Anatomy, and Pharmacological and Surgical Approaches to Treatment

    Directory of Open Access Journals (Sweden)

    Andrés Labiano-Fontcuberta

    2012-09-01

    Full Text Available Background: Given that tremor is one of the most prevalent and disabling features of multiple sclerosis (MS, we will review the most significant milestones in tremor in this disease in recent years, focusing on prevalence, clinical features, anatomical basis, and treatment.Methods: Data for this review were identified by searching MEDLINE with the search terms “multiple sclerosis” and “tremor”. References were also identified from relevant articles published between January 1966 and May 2012.Results: The predominant type of MS tremor is a large-amplitude, postural, and kinetic tremor, which most commonly affects the arms, although tremor can also involve head, neck, vocal cords, and trunk. Involvement of the tongue, jaw, or palate has not been reported. Although the anatomical basis underlying tremor in MS is poorly understood, the link between the cerebellum and the MS-related tremor is supported by clinical and experimental studies. Currently available medication is often unsuccessful in most cases. Surgical treatment can be a satisfactory alternative to treat severe and disabling tremor.Discussion: Tremor in MS patients could be considered as an advanced consequence of the disease and its presence suggests a more aggressive course. MS tremor can be severe and very disabling for a small group of patients. Treatment of MS tremor remains a great challenge. Recent studies suggest that dissociating tremor from cerebellar dysfunction using selected clinical tests would be the key issue to successful surgical treatment. Understanding the pathophysiology and biochemistry of tremor production in MS may lead to new therapeutic approaches.

  20. Toward a qualitative understanding of binge-watching behaviors: A focus group approach.

    Science.gov (United States)

    Flayelle, Maèva; Maurage, Pierre; Billieux, Joël

    2017-12-01

    Background and aims Binge-watching (i.e., seeing multiple episodes of the same TV series in a row) now constitutes a widespread phenomenon. However, little is known about the psychological factors underlying this behavior, as reflected by the paucity of available studies, most merely focusing on its potential harmfulness by applying the classic criteria used for other addictive disorders without exploring the uniqueness of binge-watching. This study thus aimed to take the opposite approach as a first step toward a genuine understanding of binge-watching behaviors through a qualitative analysis of the phenomenological characteristics of TV series watching. Methods A focus group of regular TV series viewers (N = 7) was established to explore a wide range of aspects related to TV series watching (e.g., motives, viewing practices, and related behaviors). Results A content analysis identified binge-watching features across three dimensions: TV series watching motivations, TV series watching engagement, and structural characteristics of TV shows. Most participants acknowledged that TV series watching can become addictive, but they all agreed having trouble recognizing themselves as truly being an "addict." Although obvious connections could be established with substance addiction criteria and symptoms, such parallelism appeared to be insufficient, as several distinctive facets emerged (e.g., positive view, transient overinvolvement, context dependency, and low everyday life impact). Discussion and conclusion The research should go beyond the classic biomedical and psychological models of addictive behaviors to account for binge-watching in order to explore its specificities and generate the first steps toward an adequate theoretical rationale for these emerging problematic behaviors.

  1. An Observational Approach toward Understanding and Prediction of CME Magnetic Ejecta

    Science.gov (United States)

    Pizzo, V. J.; de Koning, C. A.; Riley, P.

    2017-12-01

    Quantitative knowledge of the magnetic field inside a coronal mass ejection (CME) is an important contributor to an actionable space weather forecast of geomagnetic storms. However, at present it is not possible to predict the magnetic cloud component of a CME with any accuracy. This has led to the development of increasingly sophisticated physics-based models, each promising a path toward more accurate space weather forecasts. Unfortunately, none of these models can provide meaningful output if they lack for reliable quantitative input. Until we can measure magnetic fields at solar distances where CMEs are launched and over their early-stage evolution, this will remain a fundamental obstacle to successful modeling. Instead of continuing to focus primarily on the modeling approach, we suggest an active investigation of direct, up-stream measurement of the CME internal magnetic field. For current forecasting purposes, or even as a science concept mission, the measurements do not need to be of high accuracy or high cadence. Since previous magnetic cloud analyses have demonstrated that a single spacecraft provides insufficient data to robustly reconstruct the CME internal magnetic field, we suggest deploying a swarm of cube-sats in "quasi-satellite" orbits that are known to be horizontally and vertically stable, even at large (several tenths of an AU) distances from Earth. In this presentation, we describe how simulations of CMEs incorporating magnetic clouds can be used to develop and support this mission concept. By taking simulated cuts through model CMEs with a range of magnetic morphologies and field strengths, we aim to determine the minimum number of spacecraft needed for such a mission and their optimum orbital characteristics. Although a host of challenges remain, especially related to communications and cube-sat telemetry in interplanetary space, we believe that these technological issues can be surmounted once it has been demonstrated that a major leap in

  2. Understanding key factors affecting electronic medical record implementation: a sociotechnical approach.

    Science.gov (United States)

    Cucciniello, Maria; Lapsley, Irvine; Nasi, Greta; Pagliari, Claudia

    2015-07-17

    Recent health care policies have supported the adoption of Information and Communication Technologies (ICT) but examples of failed ICT projects in this sector have highlighted the need for a greater understanding of the processes used to implement such innovations in complex organizations. This study examined the interaction of sociological and technological factors in the implementation of an Electronic Medical Record (EMR) system by a major national hospital. It aimed to obtain insights for managers planning such projects in the future and to examine the usefulness of Actor Network Theory (ANT) as a research tool in this context. Case study using documentary analysis, interviews and observations. Qualitative thematic analysis drawing on ANT. Qualitative analyses revealed a complex network of interactions between organizational stakeholders and technology that helped to shape the system and influence its acceptance and adoption. The EMR clearly emerged as a central 'actor' within this network. The results illustrate how important it is to plan innovative and complex information systems with reference to (i) the expressed needs and involvement of different actors, starting from the initial introductory phase; (ii) promoting commitment to the system and adopting a participative approach; (iii) defining and resourcing new roles within the organization capable of supporting and sustaining the change and (iv) assessing system impacts in order to mobilize the network around a common goal. The paper highlights the organizational, cultural, technological, and financial considerations that should be taken into account when planning strategies for the implementation of EMR systems in hospital settings. It also demonstrates how ANT may be usefully deployed in evaluating such projects.

  3. Increasing nursing students' understanding and accuracy with medical dose calculations: A collaborative approach.

    Science.gov (United States)

    Mackie, Jane E; Bruce, Catherine D

    2016-05-01

    Accurate calculation of medication dosages can be challenging for nursing students. Specific interventions related to types of errors made by nursing students may improve the learning of this important skill. The objective of this study was to determine areas of challenge for students in performing medication dosage calculations in order to design interventions to improve this skill. Strengths and weaknesses in the teaching and learning of medication dosage calculations were assessed. These data were used to create online interventions which were then measured for the impact on student ability to perform medication dosage calculations. The setting of the study is one university in Canada. The qualitative research participants were 8 nursing students from years 1-3 and 8 faculty members. Quantitative results are based on test data from the same second year clinical course during the academic years 2012 and 2013. Students and faculty participated in one-to-one interviews; responses were recorded and coded for themes. Tests were implemented and scored, then data were assessed to classify the types and number of errors. Students identified conceptual understanding deficits, anxiety, low self-efficacy, and numeracy skills as primary challenges in medication dosage calculations. Faculty identified long division as a particular content challenge, and a lack of online resources for students to practice calculations. Lessons and online resources designed as an intervention to target mathematical and concepts and skills led to improved results and increases in overall pass rates for second year students for medication dosage calculation tests. This study suggests that with concerted effort and a multi-modal approach to supporting nursing students, their abilities to calculate dosages can be improved. The positive results in this study also point to the promise of cross-discipline collaborations between nursing and education. Copyright © 2016 Elsevier Ltd. All rights

  4. Experimental and Modeling Approaches for Understanding the Effect of Gene Expression Noise in Biological Development

    Directory of Open Access Journals (Sweden)

    David M. Holloway

    2018-04-01

    Full Text Available Biological development involves numerous chemical and physical processes which must act in concert to reliably produce a cell, a tissue, or a body. To be successful, the developing organism must be robust to variability at many levels, such as the environment (e.g., temperature, moisture, upstream information (such as long-range positional information gradients, or intrinsic noise due to the stochastic nature of low concentration chemical kinetics. The latter is especially relevant to the regulation of gene expression in cell differentiation. The temporal stochasticity of gene expression has been studied in single celled organisms for nearly two decades, but only recently have techniques become available to gather temporally-resolved data across spatially-distributed gene expression patterns in developing multicellular organisms. These demonstrate temporal noisy “bursting” in the number of gene transcripts per cell, raising the question of how the transcript number defining a particular cell type is produced, such that one cell type can reliably be distinguished from a neighboring cell of different type along a tissue boundary. Stochastic spatio-temporal modeling of tissue-wide expression patterns can identify signatures for specific types of gene regulation, which can be used to extract regulatory mechanism information from experimental time series. This Perspective focuses on using this type of approach to study gene expression noise during the anterior-posterior segmentation of the fruit fly embryo. Advances in experimental and theoretical techniques will lead to an increasing quantification of expression noise that can be used to understand how regulatory mechanisms contribute to embryonic robustness across a range of developmental processes.

  5. Project INTEGRATE - a common methodological approach to understand integrated health care in Europe

    Directory of Open Access Journals (Sweden)

    Lucinda Cash-Gibson

    2014-12-01

    Full Text Available Background: The use of case studies in health services research has proven to be an excellent methodology for gaining in-depth understanding of the organisation and delivery of health care. This is particularly relevant when looking at the complexity of integrated healthcare programmes, where multifaceted interactions occur at the different levels of care and often without a clear link between the interventions (new and/or existing and their impact on outcomes (in terms of patients health, both patient and professional satisfaction and cost-effectiveness. Still, integrated care is seen as a core strategy in the sustainability of health and care provision in most societies in Europe and beyond. More specifically, at present, there is neither clear evidence on transferable factors of integrated care success nor a method for determining how to establish these specific success factors. The drawback of case methodology in this case, however, is that the in-depth results or lessons generated are usually highly context-specific and thus brings the challenge of transferability of findings to other settings, as different health care systems and different indications are often not comparable. Project INTEGRATE, a European Commission-funded project, has been designed to overcome these problems; it looks into four chronic conditions in different European settings, under a common methodology framework (taking a mixed-methods approach to try to overcome the issue of context specificity and limited transferability. The common methodological framework described in this paper seeks to bring together the different case study findings in a way that key lessons may be derived and transferred between countries, contexts and patient-groups, where integrated care is delivered in order to provide insight into generalisability and build on existing evidence in this field.Methodology: To compare the different integrated care experiences, a mixed-methods approach has

  6. Examining the Reggio Emilia Approach: Keys to Understanding Why It Motivates Students

    Science.gov (United States)

    Gardner, Alexa Fraley; Jones, Brett D.

    2016-01-01

    Because of the success of the Reggio Emilia Approach in early childhood education, it could be useful to researchers and practitioners to identify and explicate components of the approach that make it effective in motivating students. In this paper, we examine the Reggio Emilia Approach through the lens of the MUSIC® Model of Motivation, a model…

  7. A regional distributed hydrological modelling approach for flash-flood understanding and experimental design

    Science.gov (United States)

    Braud, Isabelle; Anquetin, Sandrine; Roux, Hélène; Vannier, Olivier; Maubourguet, Marie-Madeleine; Viallet, Pierre; Boudevillain, Brice; Dartus, Denis; Creutin, Jean-Dominique

    2010-05-01

    Flash floods represent the most destructive natural hazard in the Mediterranean region, causing around one billion Euros worth of damage in France over the last two decades. Flash floods are associated with extreme and rare rainfall events and usually occur in ungauged river basins. Amongst them, small-ungauged catchments are recognized as the most vulnerable to storm driven flash floods. In order to limit the damages to the population, there is a need to improve our understanding and the simulation tools for these events. In order to provide information over a whole region, hydrological models applicable at this scale, and able to take into account the spatial variability of rainfall and catchment characteristics, must be proposed. This paper presents such a regional distributed approach applied to the 8-9 September 2002 extreme event which affected the Gard region in the south-east of France. In order to identify the variables and catchment characteristics which require improved knowledge, two distributed hydrological models were set up on a set of catchments, with sizes ranging from 2.5 to 99 km2. The models differ in terms of spatial discretization and process representation. They were forced using radar data with a 1 km2 spatial resolution and 5 min time step. The model parameters were specified using the available information, namely a digital terrain model and a soil data base. The latter provides information about soil texture, soil porosity and soil depths. Soil hydraulic properties were defined using pedo-transfer functions. Data from a post-flood field survey of maximum peak discharge were used to assess the quality of the simulations. A reasonable agreement between modeled and observed values was obtained. Sensitivity studies were then performed to asses the respective impact of rainfall estimation and soil variability on the simulated discharge. The analysis shows that rainfall remains the first controlling factor of flash flood dynamics and that high

  8. Simulation-Based Performance Assessment: An Innovative Approach to Exploring Understanding of Physical Science Concepts

    Science.gov (United States)

    Gale, Jessica; Wind, Stefanie; Koval, Jayma; Dagosta, Joseph; Ryan, Mike; Usselman, Marion

    2016-01-01

    This paper illustrates the use of simulation-based performance assessment (PA) methodology in a recent study of eighth-grade students' understanding of physical science concepts. A set of four simulation-based PA tasks were iteratively developed to assess student understanding of an array of physical science concepts, including net force,…

  9. A Socio-Cognitive Approach to How Children with Deafblindness Understand Symbols

    Science.gov (United States)

    Hartmann, Elizabeth S.

    2012-01-01

    Children with congenital deafblindness are a population of learners who may need intervention in order to develop symbolic understanding. They experience a combination of vision and hearing impairments that can affect how they make sense of the world, develop relationships, and understand symbols. In this article, the author reviewed a…

  10. Understanding factors associated with the translation of cardiovascular research: a multinational case study approach

    Science.gov (United States)

    2014-01-01

    Background Funders of health research increasingly seek to understand how best to allocate resources in order to achieve maximum value from their funding. We built an international consortium and developed a multinational case study approach to assess benefits arising from health research. We used that to facilitate analysis of factors in the production of research that might be associated with translating research findings into wider impacts, and the complexities involved. Methods We built on the Payback Framework and expanded its application through conducting co-ordinated case studies on the payback from cardiovascular and stroke research in Australia, Canada and the United Kingdom. We selected a stratified random sample of projects from leading medical research funders. We devised a series of innovative steps to: minimize the effect of researcher bias; rate the level of impacts identified in the case studies; and interrogate case study narratives to identify factors that correlated with achieving high or low levels of impact. Results Twenty-nine detailed case studies produced many and diverse impacts. Over the 15 to 20 years examined, basic biomedical research has a greater impact than clinical research in terms of academic impacts such as knowledge production and research capacity building. Clinical research has greater levels of wider impact on health policies, practice, and generating health gains. There was no correlation between knowledge production and wider impacts. We identified various factors associated with high impact. Interaction between researchers and practitioners and the public is associated with achieving high academic impact and translation into wider impacts, as is basic research conducted with a clinical focus. Strategic thinking by clinical researchers, in terms of thinking through pathways by which research could potentially be translated into practice, is associated with high wider impact. Finally, we identified the complexity of

  11. Assessing and understanding sedentary behaviour in office-based working adults: a mixed-method approach

    Directory of Open Access Journals (Sweden)

    Clarice N. Waters

    2016-04-01

    Full Text Available Abstract Background Sedentary behaviours (SB can be characterized by low energy expenditure in a reclining position (e.g., sitting often associated with work and transport. Prolonged SB is associated with increased risk for chronic conditions, and due to technological advances, the working population is in office settings with high occupational exposure to SB. This study aims to assess SB among office workers, as well as barriers and strategies towards reducing SB in the work setting. Methods Using a mixed-methods approach guided by the socio-ecological framework, non-academic office workers from a professional school in a large public university were recruited. Of 180 eligible office workers, 40 enrolled and completed all assessments. Self-reported and objectively measured SB and activity levels were captured. Focus group discussion (FGD were conducted to further understand perceptions, barriers, and strategies to reducing workplace SB. Environmental factors were systematically evaluated by trained research staff using an adapted version of the Checklist for Health Promotion Environments at Worksites (CHEW. Thematic analysis of FGD was conducted and descriptive analysis of quantitative data was performed. Results The sample was mostly Chinese (n = 33, 80 % with a total of 24 (60 % female participants. Most participants worked five days a week for about 9.5(0.5 hrs/day. Accelerometer data show that participants spend the majority of their days in sedentary activities both on workdays (76.9 % and non-workdays (69.5 %. Self-report data confirm these findings with median sitting time of 420(180 minutes at work. From qualitative analyses, major barriers to reducing SB emerged, including the following themes: workplace social and cultural norms, personal factors, job scope, and physical building/office infrastructure. CHEW results confirm a lack of support from the physical infrastructure and information environment to reducing SB

  12. Assessing and understanding sedentary behaviour in office-based working adults: a mixed-method approach.

    Science.gov (United States)

    Waters, Clarice N; Ling, Er Pei; Chu, Anne H Y; Ng, Sheryl H X; Chia, Audrey; Lim, Yee Wei; Müller-Riemenschneider, Falk

    2016-04-27

    Sedentary behaviours (SB) can be characterized by low energy expenditure in a reclining position (e.g., sitting) often associated with work and transport. Prolonged SB is associated with increased risk for chronic conditions, and due to technological advances, the working population is in office settings with high occupational exposure to SB. This study aims to assess SB among office workers, as well as barriers and strategies towards reducing SB in the work setting. Using a mixed-methods approach guided by the socio-ecological framework, non-academic office workers from a professional school in a large public university were recruited. Of 180 eligible office workers, 40 enrolled and completed all assessments. Self-reported and objectively measured SB and activity levels were captured. Focus group discussion (FGD) were conducted to further understand perceptions, barriers, and strategies to reducing workplace SB. Environmental factors were systematically evaluated by trained research staff using an adapted version of the Checklist for Health Promotion Environments at Worksites (CHEW). Thematic analysis of FGD was conducted and descriptive analysis of quantitative data was performed. The sample was mostly Chinese (n = 33, 80 %) with a total of 24 (60 %) female participants. Most participants worked five days a week for about 9.5(0.5) hrs/day. Accelerometer data show that participants spend the majority of their days in sedentary activities both on workdays (76.9 %) and non-workdays (69.5 %). Self-report data confirm these findings with median sitting time of 420(180) minutes at work. From qualitative analyses, major barriers to reducing SB emerged, including the following themes: workplace social and cultural norms, personal factors, job scope, and physical building/office infrastructure. CHEW results confirm a lack of support from the physical infrastructure and information environment to reducing SB. There is high SB among office workers in this sample. We

  13. A Functional Approach towards Understanding the Role of the Mitochondrial Respiratory Chain in an Endomycorrhizal Symbiosis

    Science.gov (United States)

    Mercy, Louis; Lucic-Mercy, Eva; Nogales, Amaia; Poghosyan, Areg; Schneider, Carolin; Arnholdt-Schmitt, Birgit

    2017-01-01

    Arbuscular mycorrhizal fungi (AMF) are crucial components of fertile soils, able to provide several ecosystem services for crop production. Current economic, social and legislative contexts should drive the so-called “second green revolution” by better exploiting these beneficial microorganisms. Many challenges still need to be overcome to better understand the mycorrhizal symbiosis, among which (i) the biotrophic nature of AMF, constraining their production, while (ii) phosphate acts as a limiting factor for the optimal mycorrhizal inoculum application and effectiveness. Organism fitness and adaptation to the changing environment can be driven by the modulation of mitochondrial respiratory chain, strongly connected to the phosphorus processing. Nevertheless, the role of the respiratory function in mycorrhiza remains largely unexplored. We hypothesized that the two mitochondrial respiratory chain components, alternative oxidase (AOX) and cytochrome oxidase (COX), are involved in specific mycorrhizal behavior. For this, a complex approach was developed. At the pre-symbiotic phase (axenic conditions), we studied phenotypic responses of Rhizoglomus irregulare spores with two AOX and COX inhibitors [respectively, salicylhydroxamic acid (SHAM) and potassium cyanide (KCN)] and two growth regulators (abscisic acid – ABA and gibberellic acid – Ga3). At the symbiotic phase, we analyzed phenotypic and transcriptomic (genes involved in respiration, transport, and fermentation) responses in Solanum tuberosum/Rhizoglomus irregulare biosystem (glasshouse conditions): we monitored the effects driven by ABA, and explored the modulations induced by SHAM and KCN under five phosphorus concentrations. KCN and SHAM inhibited in vitro spore germination while ABA and Ga3 induced differential spore germination and hyphal patterns. ABA promoted mycorrhizal colonization, strong arbuscule intensity and positive mycorrhizal growth dependency (MGD). In ABA treated plants, R. irregulare

  14. Innovative Approaches to Understanding Transportation/Societal Interactions. Volume 2 : Study Design Reports

    Science.gov (United States)

    1981-10-01

    In 1979, the Transportation Systems Center (TSC), under sponsorship of the Urban Mass Transportation Administration (UMTA), began a program of research directed toward improving the understanding of the role of transportation in society, in particula...

  15. A Mistake Based Approach Probing Students' Under-standing of PV ...

    Indian Academy of Sciences (India)

    PV-type work done, presents onesuch example. Classifying the systematic mistakes made bystudents in response to a concept-based question on workdone in thermodynamics, and sharing them across a publicforum results in a paradigm of learning called the 'mistakebased approach'. This approach is a subset of a ...

  16. Seeking Serendipity : A Living Lab Approach to Understanding Creative Retrieval in Broadcast Media Production

    NARCIS (Netherlands)

    Sauer, S.; de Rijke, M.

    2016-01-01

    This paper presents a method to map user needs and integrate serendipitous search behaviors in search algorithm development: the living lab approach. This user-centered design approach involves technology users during technology development to catch unexpected insights and successfully innovate.

  17. In search of an adaptive social-ecological approach to understanding a tropical city

    Science.gov (United States)

    A.E. Lugo; C.M. Concepcion; L.E. Santiago-Acevedo; T.A. Munoz-Erickson; J.C. Verdejo Ortiz; R. Santiago-Bartolomei; J. Forero-Montana; C.J. Nytch; H. Manrique; W. Colon-Cortes

    2012-01-01

    This essay describes our effort to develop a practical approach to the integration of the social and ecological sciences in the context of a Latin-American city such as San Juan, Puerto Rico. We describe our adaptive social-ecological approach in the historical context of the developing paradigms of the Anthropocene, new integrative social and ecological sciences, and...

  18. The Effectiveness of the Brain Based Teaching Approach in Enhancing Scientific Understanding of Newtonian Physics among Form Four Students

    Science.gov (United States)

    Saleh, Salmiza

    2012-01-01

    The aim of this study was to assess the effectiveness of Brain Based Teaching Approach in enhancing students' scientific understanding of Newtonian Physics in the context of Form Four Physics instruction. The technique was implemented based on the Brain Based Learning Principles developed by Caine & Caine (1991, 2003). This brain compatible…

  19. Comparison of Two Different Techniques of Cooperative Learning Approach: Undergraduates' Conceptual Understanding in the Context of Hormone Biochemistry

    Science.gov (United States)

    Mutlu, Ayfer

    2018-01-01

    The purpose of the research was to compare the effects of two different techniques of the cooperative learning approach, namely Team-Game Tournament and Jigsaw, on undergraduates' conceptual understanding in a Hormone Biochemistry course. Undergraduates were randomly assigned to Group 1 (N = 23) and Group 2 (N = 29). Instructions were accomplished…

  20. The effect of problem posing and problem solving with realistic mathematics education approach to the conceptual understanding and adaptive reasoning

    Science.gov (United States)

    Mahendra, Rengga; Slamet, Isnandar; Budiyono

    2017-12-01

    One of the difficulties of students in learning mathematics is on the subject of geometry that requires students to understand abstract things. The aim of this research is to determine the effect of learning model Problem Posing and Problem Solving with Realistic Mathematics Education Approach to conceptual understanding and students' adaptive reasoning in learning mathematics. This research uses a kind of quasi experimental research. The population of this research is all seventh grade students of Junior High School 1 Jaten, Indonesia. The sample was taken using stratified cluster random sampling technique. The test of the research hypothesis was analyzed by using t-test. The results of this study indicate that the model of Problem Posing learning with Realistic Mathematics Education Approach can improve students' conceptual understanding significantly in mathematics learning. In addition tu, the results also showed that the model of Problem Solving learning with Realistic Mathematics Education Approach can improve students' adaptive reasoning significantly in learning mathematics. Therefore, the model of Problem Posing and Problem Solving learning with Realistic Mathematics Education Approach is appropriately applied in mathematics learning especially on the subject of geometry so as to improve conceptual understanding and students' adaptive reasoning. Furthermore, the impact can improve student achievement.

  1. The Effect of Cooperative Learning Approach Based on Conceptual Change Condition on Students' Understanding of Chemical Equilibrium Concepts

    Science.gov (United States)

    Bilgin, Ibrahim; Geban, Omer

    2006-01-01

    The purpose of this study is to investigate the effects of the cooperative learning approach based on conceptual change conditions over traditional instruction on 10th grade students' conceptual understanding and achievement of computational problems related to chemical equilibrium concepts. The subjects of this study consisted of 87 tenth grade…

  2. Do Pre-Service Science Teachers Have Understanding of the Nature of Science?: Explicit-Reflective Approach

    Science.gov (United States)

    Örnek, Funda; Turkey, Kocaeli

    2014-01-01

    Current approaches in Science Education attempt to enable students to develop an understanding of the nature of science, develop fundamental scientific concepts, and develop the ability to structure, analyze, reason, and communicate effectively. Students pose, solve, and interpret scientific problems, and eventually set goals and regulate their…

  3. Proud to be in control : Understanding concern conflicts and initial principles for conflict-inspired design approaches

    NARCIS (Netherlands)

    Ozkaramanli, D.; Desmet, P.M.A.; Hekkert, P.P.M.

    2012-01-01

    The purpose of this paper is to increase our understanding of how insights in conflicting concerns can be used as an approach to design for subjective well-being. This is done through examining qualities of a conflict experience across three life domains: food, procrastination, and safe sex. Ten

  4. The Effectiveness of the Geospatial Curriculum Approach on Urban Middle-Level Students' Climate Change Understandings

    Science.gov (United States)

    Bodzin, Alec M.; Fu, Qiong

    2014-01-01

    Climate change science is a challenging topic for student learning. This quantitative study examined the effectiveness of a geospatial curriculum approach to promote climate change science understandings in an urban school district with eighth-grade students and investigated whether teacher- and student-level factors accounted for students'…

  5. Using the resurrection approach to understand contemporary evolution in changing environments.

    Science.gov (United States)

    Franks, Steven J; Hamann, Elena; Weis, Arthur E

    2018-01-01

    The resurrection approach of reviving ancestors from stored propagules and comparing them with descendants under common conditions has emerged as a powerful method of detecting and characterizing contemporary evolution. As climatic and other environmental conditions continue to change at a rapid pace, this approach is becoming particularly useful for predicting and monitoring evolutionary responses. We evaluate this approach, explain the advantages and limitations, suggest best practices for implementation, review studies in which this approach has been used, and explore how it can be incorporated into conservation and management efforts. We find that although the approach has thus far been used in a limited number of cases, these studies have provided strong evidence for rapid contemporary adaptive evolution in a variety of systems, particularly in response to anthropogenic environmental change, although it is far from clear that evolution will be able to rescue many populations from extinction given current rates of global changes. We also highlight one effort, known as Project Baseline, to create a collection of stored seeds that can take advantage of the resurrection approach to examine evolutionary responses to environmental change over the coming decades. We conclude that the resurrection approach is a useful tool that could be more widely employed to examine basic questions about evolution in natural populations and to assist in the conservation and management of these populations as they face continued environmental change.

  6. Integrating Modelling Approaches for Understanding Telecoupling: Global Food Trade and Local Land Use

    Directory of Open Access Journals (Sweden)

    James D. A. Millington

    2017-08-01

    Full Text Available The telecoupling framework is an integrated concept that emphasises socioeconomic and environmental interactions between distant places. Viewed through the lens of the telecoupling framework, land use and food consumption are linked across local to global scales by decision-making agents and trade flows. Quantitatively modelling the dynamics of telecoupled systems like this could be achieved using numerous different modelling approaches. For example, previous approaches to modelling global food trade have often used partial equilibrium economic models, whereas recent approaches to representing local land use decision-making have widely used agent-based modelling. System dynamics models are well established for representing aggregated flows and stores of products and values between distant locations. We argue that hybrid computational models will be useful for capitalising on the strengths these different modelling approaches each have for representing the various concepts in the telecoupling framework. However, integrating multiple modelling approaches into hybrid models faces challenges, including data requirements and uncertainty assessment. To help guide the development of hybrid models for investigating sustainability through the telecoupling framework here we examine important representational and modelling considerations in the context of global food trade and local land use. We report on the development of our own model that incorporates multiple modelling approaches in a modular approach to negotiate the trade-offs between ideal representation and modelling resource constraints. In this initial modelling our focus is on land use and food trade in and between USA, China and Brazil, but also accounting for the rest of the world. We discuss the challenges of integrating multiple modelling approaches to enable analysis of agents, flows, and feedbacks in the telecoupled system. Our analysis indicates differences in representation of agency

  7. THE PHYSICAL LABORATORY ACTIVITIES WITH PROBLEM SOLVING APPROACH TO INCREASE CRITICAL THINKING SKILL AND UNDERSTANDING STUDENT CONCEPT

    Directory of Open Access Journals (Sweden)

    Eli Trisnowati

    2017-10-01

    Full Text Available This study aims to investigate the description of the improvement of students’ critical thinking skills and the concept understanding by implementing the problem-solving approach. This study was in laboratory activities. This study was done in four times meeting. The try out subjects was 31 students of grades X of MAN Yogyakarta III. This research is using the quasi experimental method with the pretest-posttest design. The data were collected by using multiple choices tests with assessment rubric and observation sheets. The data are analyzed by using multivariate analysis. Based on the result, the gain standard value of students’ conceptual understanding and students’ critical thinking skills for grade X who learned through student’s worksheet with a problem-solving approach, called treatment class, are higher than students who learned without student’s worksheet with a problem-solving approach, called control class.

  8. Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach.

    Science.gov (United States)

    Niculescu, A B; Levey, D F; Phalen, P L; Le-Niculescu, H; Dainton, H D; Jain, N; Belanger, E; James, A; George, S; Weber, H; Graham, D L; Schweitzer, R; Ladd, T B; Learman, R; Niculescu, E M; Vanipenta, N P; Khan, F N; Mullen, J; Shankar, G; Cook, S; Humbert, C; Ballew, A; Yard, M; Gelbart, T; Shekhar, A; Schork, N J; Kurian, S M; Sandusky, G E; Salomon, D R

    2015-11-01

    Worldwide, one person dies every 40 seconds by suicide, a potentially preventable tragedy. A limiting step in our ability to intervene is the lack of objective, reliable predictors. We have previously provided proof of principle for the use of blood gene expression biomarkers to predict future hospitalizations due to suicidality, in male bipolar disorder participants. We now generalize the discovery, prioritization, validation, and testing of such markers across major psychiatric disorders (bipolar disorder, major depressive disorder, schizoaffective disorder, and schizophrenia) in male participants, to understand commonalities and differences. We used a powerful within-participant discovery approach to identify genes that change in expression between no suicidal ideation and high suicidal ideation states (n=37 participants out of a cohort of 217 psychiatric participants followed longitudinally). We then used a convergent functional genomics (CFG) approach with existing prior evidence in the field to prioritize the candidate biomarkers identified in the discovery step. Next, we validated the top biomarkers from the prioritization step for relevance to suicidal behavior, in a demographically matched cohort of suicide completers from the coroner's office (n=26). The biomarkers for suicidal ideation only are enriched for genes involved in neuronal connectivity and schizophrenia, the biomarkers also validated for suicidal behavior are enriched for genes involved in neuronal activity and mood. The 76 biomarkers that survived Bonferroni correction after validation for suicidal behavior map to biological pathways involved in immune and inflammatory response, mTOR signaling and growth factor regulation. mTOR signaling is necessary for the effects of the rapid-acting antidepressant agent ketamine, providing a novel biological rationale for its possible use in treating acute suicidality. Similarly, MAOB, a target of antidepressant inhibitors, was one of the increased

  9. Contemporary understanding of riots: Classical crowd psychology, ideology and the social identity approach.

    Science.gov (United States)

    Stott, Clifford; Drury, John

    2016-04-01

    This article explores the origins and ideology of classical crowd psychology, a body of theory reflected in contemporary popularised understandings such as of the 2011 English 'riots'. This article argues that during the nineteenth century, the crowd came to symbolise a fear of 'mass society' and that 'classical' crowd psychology was a product of these fears. Classical crowd psychology pathologised, reified and decontextualised the crowd, offering the ruling elites a perceived opportunity to control it. We contend that classical theory misrepresents crowd psychology and survives in contemporary understanding because it is ideological. We conclude by discussing how classical theory has been supplanted in academic contexts by an identity-based crowd psychology that restores the meaning to crowd action, replaces it in its social context and in so doing transforms theoretical understanding of 'riots' and the nature of the self. © The Author(s) 2016.

  10. Socializing Infants toward a Cultural Understanding of Expressing Negative Affect: A Bakhtinian Informed Discursive Psychology Approach

    Science.gov (United States)

    Demuth, Carolin

    2013-01-01

    This article addresses the socialization of emotion expression in infancy. It argues that in order to adequately understand emotion development we need to consider the appraisal of emotion expression through caregivers in mundane, everyday interactions. Drawing on sociocultural and Bakhtinian theorizing, it claims that caregivers' appraisals of…

  11. Understanding learning in natural resource management : experiences with a contextualised responsive evaluation approach

    NARCIS (Netherlands)

    Kouévi, T.A.

    2013-01-01

    This dissertation may be located in the wide debate on the effectiveness of policy interventions in developing countries, in the field of natural resource management (NRM). It is especially concerned with contributing to the understanding of the limited effectiveness of fishery management

  12. A comparative gradient approach as a tool for understanding and managing urban ecosystems

    Science.gov (United States)

    Christopher G. Boone; Elizabeth Cook; Sharon J. Hall; Marcia L. Nation; Nancy B. Grimm; Carol B. Raish; Deborah M. Finch; Abigail M. York

    2012-01-01

    To meet the grand challenges of the urban century - such as climate change, biodiversity loss, and persistent poverty - urban and ecological theory must contribute to integrated frameworks that treat social and ecological dynamics as interdependent. A socioecological framework that encapsulates theory from the social and ecological sciences will improve understanding...

  13. Understanding the Conceptual Development Phase of Applied Theory-Building Research: A Grounded Approach

    Science.gov (United States)

    Storberg-Walker, Julia

    2007-01-01

    This article presents a provisional grounded theory of conceptual development for applied theory-building research. The theory described here extends the understanding of the components of conceptual development and provides generalized relations among the components. The conceptual development phase of theory-building research has been widely…

  14. A process approach to children's understanding of scientific concepts : A longitudinal case study

    NARCIS (Netherlands)

    van der Steen, Steffie; Steenbeek, Henderien; van Dijk, Marijn; van Geert, Paul

    In order to optimally study changes in the complexity of understanding, microgenetic measures are needed, and a coupling of these to longer-term measures. We focus on the interaction dynamics between a 4-year old boy and a researcher while they work on tasks about air pressure in three subsequent

  15. Enhancing Intercultural Communication and Understanding: Team Translation Project as a Student Engagement Learning Approach

    Science.gov (United States)

    Yang, Ping

    2015-01-01

    This paper reflects on a team translation project on Aboriginal culture designed to enhance university students' intercultural communication competence and understanding through engaging in an interactive team translation project funded by the Australia-China Council. A selected group of Chinese speaking translation students participated in the…

  16. A Bourdieusian Approach to Understanding Employability: Becoming a "Fish in Water"

    Science.gov (United States)

    Clark, Martyn; Zukas, Miriam

    2013-01-01

    It is assumed in the current policy environment that higher education should lead to graduate employability, although understandings of employability are generally limited. In this paper, we discuss issues relating to graduate employability with reference to a case study of an information technology (IT) student progressing to a graduate role in…

  17. A social network approach to understanding science communication among fire professionals

    Science.gov (United States)

    Vita Wright

    2012-01-01

    Studies of science communication and use in the fire management community suggest manager's access research via informal information networks and that these networks vary by both agency and position. We used a phone survey followed by traditional statistical analyses to understand the informal social networks of fire professionals in two western regions of the...

  18. Students' Understanding of Genetics Concepts: The Effect of Reasoning Ability and Learning Approaches

    Science.gov (United States)

    Kiliç, Didem; Saglam, Necdet

    2014-01-01

    Students tend to learn genetics by rote and may not realise the interrelationships in daily life. Because reasoning abilities are necessary to construct relationships between concepts and rote learning impedes the students' sound understanding, it was predicted that having high level of formal reasoning and adopting meaningful learning orientation…

  19. A Behavioral Approach to Understanding Green Consumerism Using Latent Class Choice Analysis

    DEFF Research Database (Denmark)

    Peschel, Anne Odile; Grebitus, Carola; Steiner, Bodo

    To better understand motivations of consumers making choices among sustainability-labeled food products, this paper analyzes drivers of stated choices for a dietary staple labeled with carbon and water foodprints. Latent class modeling of survey responses reveals distinct consumer segments based ...

  20. Using a metagenomic approach to improve our understanding of Armillaria root disease

    Science.gov (United States)

    Amy Ross-Davis; Matt Settles; John W. Hanna; John D. Shaw; Andrew T. Hudak; Deborah S. Page-Dumroese; Ned B. Klopfenstein

    2015-01-01

    Metagenomics has illuminated our understanding of how microbial communities influence health and disease. Researchers are beginning to characterize what constitutes healthy microbiota in terms of structure, function, and diversity in a variety of environments. Although investigation lags behind the more well-studied human microbiome, a growing body of research is using...

  1. A Behavioral Approach to Understanding Green Consumerism Using Latent Class Choice Analysis

    DEFF Research Database (Denmark)

    Peschel, Anne Odile; Grebitus, Carola; Steiner, Bodo

    To better understand motivations of consumers making choices among sustainability-labeled food products, this paper analyzes drivers of stated choices for a dietary staple labeled with carbon and water foodprints. Latent class modeling of survey responses reveals distinct consumer segments based...

  2. Effect of Conceptual Change Approach on Students' Understanding of Reaction Rate Concepts

    Science.gov (United States)

    Kingir, Sevgi; Geban, Omer

    2012-01-01

    The purpose of the present study was to investigate the effect of conceptual change text oriented instruction compared to traditional instruction on 10th grade students' understanding of reaction rate concepts. 45 students from two classes of the same teacher in a public high school participated in this study. Students in the experimental group…

  3. A Qualitative Approach to Understanding Audience's Perceptions of Creativity in Online Advertising

    Science.gov (United States)

    McStay, Andrew

    2010-01-01

    In this paper I seek to inquire upon audience's perceptions of creativity in online advertising--a heretofore poorly understood area. This paper initially outlines current academic understanding of creativity in online advertising, mainly derived from quantitative assessments. It then advances a qualitative methodology including diary-interviews…

  4. An interdisciplinary approach towards improved understanding of soil deformation during compaction

    DEFF Research Database (Denmark)

    Keller, T.; Lamandé, Mathieu; Peth, S.

    2013-01-01

    Soil compaction not only reduces available pore volume in which fluids are stored, but it alters the arrangement of soil constituents and pore geometry, thereby adversely impacting fluid transport and a range of soil ecological functions. Quantitative understanding of stress transmission and defo...

  5. Understanding learning in natural resource management : experiences with a contextualised responsive evaluation approach

    NARCIS (Netherlands)

    Kouévi, T.A.

    2013-01-01

    This dissertation may be located in the wide debate on the effectiveness of policy interventions in developing countries, in the field of natural resource management (NRM). It is especially concerned with contributing to the understanding of the limited effectiveness of fishery management

  6. Environmental Identity: A New Approach to Understanding Students' Participation in Environmental Learning Programs

    Science.gov (United States)

    Jaksha, Amanda P.

    2013-01-01

    The goal of this study is to develop an understanding of how participants express their environmental identities during an environmental learning program. Past research on the outcomes of environmental learning programs has focused primarily on changes in knowledge and attitudes. However, even if knowledge or attitudes can be accurately measured,…

  7. Analysis of Student-Teacher Cognitive Styles Interaction: An Approach to Understanding Learner Performance

    Science.gov (United States)

    Sellah, Lusweti; Jacinta, Kwena; Helen, Mondoh

    2017-01-01

    Cognitive styles are persistent patterns of behavior that determine how an individual acquires and processes information. In the classroom the cognitive styles of the teacher interact with those of the learner resulting in differential understanding. This study which is informed by cognitive styles theories is a descriptive study that examined the…

  8. A social network approach to understanding science communication among fire professionals (Abstract)

    Science.gov (United States)

    Vita Wright; Andrea Thode; Anne Mottek-Lucas; Jacklynn Fallon; Megan Matonis

    2012-01-01

    Studies of science communication and use in the fire management community suggest manager's access research via informal information networks and that these networks vary by both agency and position. We used a phone survey followed by traditional statistical analyses to understand the informal social networks of fire professionals in two western regions of the...

  9. An Integrated Academic Literacy Approach to Improving Students' Understanding of Plagiarism in an Accounting Course

    Science.gov (United States)

    Powell, Lisa; Singh, Nishani

    2016-01-01

    Plagiarism in higher education is a widespread and complex issue. Students' understanding of plagiarism differs as a result of combining their prior learning about referencing with their current experience of institutional policies and generic resources. Plagiarism was identified as a major learning issue in a core second-year undergraduate…

  10. A trait-based approach to understanding marine communities composition, assembly and diversity

    DEFF Research Database (Denmark)

    Pécuchet, Lauréne

    A species occurs and thrives in a community thanks to its capacity to grow, reproduce and feed in its surrounding environment. Understanding how and why some species thrive in particular areas has often been touched upon by studying the species composition of communities. Traditionally, communities...

  11. On Predictive Understanding of Extreme Events: Pattern Recognition Approach; Prediction Algorithms; Applications to Disaster Preparedness

    Science.gov (United States)

    Keilis-Borok, V. I.; Soloviev, A.; Gabrielov, A.

    2011-12-01

    We describe a uniform approach to predicting different extreme events, also known as critical phenomena, disasters, or crises. The following types of such events are considered: strong earthquakes; economic recessions (their onset and termination); surges of unemployment; surges of crime; and electoral changes of the governing party. A uniform approach is possible due to the common feature of these events: each of them is generated by a certain hierarchical dissipative complex system. After a coarse-graining, such systems exhibit regular behavior patterns; we look among them for "premonitory patterns" that signal the approach of an extreme event. We introduce methodology, based on the optimal control theory, assisting disaster management in choosing optimal set of disaster preparedness measures undertaken in response to a prediction. Predictions with their currently realistic (limited) accuracy do allow preventing a considerable part of the damage by a hierarchy of preparedness measures. Accuracy of prediction should be known, but not necessarily high.

  12. Adopting a critical intercultural communication approach to understanding health professionals' encounter with ethnic minority patients

    DEFF Research Database (Denmark)

    Jæger, Kirsten

    2012-01-01

    professionals and their approach to ethnic minority patients influence the accessibility of healthcare and availability of health prevention resources of ethnic minorities. When adapting healthcare practice to minority patients, healthcare professionals draw on insights from intercultural communication...... and anthropology. However, within these disciplines such concepts as culture, interculturality, and ethnicity are subjected to contestation due to co-existing, but competing paradigms. This paper demonstrates how healthcare discourses on ethnic minority patients reflect shifting intercultural communication...... paradigms and advocates the adoption of a critical intercultural communication approach in relation to ethnicity-based health inequality....

  13. Understanding the ecological validity of neuropsychological testing using an ethnographic approach.

    Science.gov (United States)

    Gioia, Deborah

    2009-10-01

    Neurocognitive impairment is a defining and disabling feature of schizophrenia and other physical disorders. Most of our understanding about neurocognitive deficits comes from laboratory-based testing in research protocols. There has been little research using direct behavioral community observation over a prolonged period to understand the association of daily functioning with cognitive performance.The purpose of this study was to develop an observational method that could be replicated by researchers interested in viewing cognitive deficits in vivo, and then comparing this data to laboratory measures to affirm the ecological validity of those measures.The eight-step method explained here was developed from the targeted ethnographic study of 10 persons with schizophrenia. Obtaining real world context with this method will help to increase the generalizability of effective cognitive treatments, create improved interventions for this population, and bring into greater relief the coping and compensatory strategies already used by individuals to complete daily tasks.

  14. An Evolutionary Modelling Approach To Understanding The Factors Behind Plant Invasiveness And Community Susceptibility To Invasion

    DEFF Research Database (Denmark)

    Warren, John; Topping, Christopher John; James, Penri

    2011-01-01

    Ecologists have had limited success in understanding which introduced species may become invasive. An evolutionary model is used to investigate which traits are associated with invasiveness. Translocation experiments were simulated in which species were moved into similar but evolutionary younger...... observed to be species and community combination specific. This evolutionary study represents a novel in silico attempt to tackle invasiveness in an experimental framework, and may provide a new methodology for tackling these issues....

  15. A multi-level approach to understanding the impact of cyber crime on the financial sector

    OpenAIRE

    Monica Lagazio; Nazneen Sherif; Mike Cushman

    2014-01-01

    This paper puts forward a multi-level model, based on system dynamics methodology, to understand the impact of cyber crime on the financial sector. Consistent with recent findings, our results show that strong dynamic relationships, amongst tangible and intangible factors, affect cyber crime cost and occur at different levels of society and value network. Specifically, shifts in financial companies’ strategic priorities, having the protection of customer trust and loyalty as a key objective, ...

  16. A Geovisual Analytic Approach to Understanding Geo-Social Relationships in the International Trade Network

    OpenAIRE

    Luo, Wei; Yin, Peifeng; Di, Qian; Hardisty, Frank; MacEachren, Alan M.

    2014-01-01

    The world has become a complex set of geo-social systems interconnected by networks, including transportation networks, telecommunications, and the internet. Understanding the interactions between spatial and social relationships within such geo-social systems is a challenge. This research aims to address this challenge through the framework of geovisual analytics. We present the GeoSocialApp which implements traditional network analysis methods in the context of explicitly spatial and social...

  17. A Systems Approach to Understanding Occupational Therapy Service Negotiations in a Preschool Setting

    Science.gov (United States)

    Silverman, Fern; Kramer, Paula; Ravitch, Sharon

    2011-01-01

    The purpose of this study was to use a systems approach to examine informal communications, meaning those occurring outside of scheduled meetings, among stakeholders in a preschool early intervention program. This investigation expands the discussion of how occupational therapy treatment decisions are made in educational settings by using a…

  18. Inherit the Policy: A Sociocultural Approach to Understanding Evolutionary Biology Policy in South Carolina

    Science.gov (United States)

    Moore, Gregory D.

    2012-01-01

    South Carolina biology Indicator 5.6 calls for students to "Summarize ways that scientists use data from a variety of sources to investigate and critically analyze aspects of evolutionary theory" (South Carolina Department of Education, 2006). Levinson and Sutton (2001) offered a sociocultural approach to policy that considers cultural…

  19. Creating Rich Portraits: A Mixed-Methods Approach to Understanding Profiles of Intrinsic and Extrinsic Motivations

    Science.gov (United States)

    Corpus, Jennifer Henderlong; Wormington, Stephanie V.; Haimovitz, Kyla

    2016-01-01

    A person-centered, mixed-methods approach (self-report surveys, semistructured interviews, school records) was used to characterize and evaluate profiles of intrinsic and extrinsic motivations among 243 third- through eighth-grade students. Cluster analysis suggested four distinct profiles: high quantity (high intrinsic, high extrinsic), primarily…

  20. Understanding perception of wood household furniture: application of a policy capturing approach

    Science.gov (United States)

    David Brinberg; Matthew Bumgardner; Kim Daniloski

    2007-01-01

    Consumer and retailer perceptions of wood household furniture were modeled using a policy capturing approach. A sample of consumers and retailers evaluated four pictures of wood furniture on eight visual cues deemed representative of the furniture purchasing environment. These cues were then regressed on respondents' judgment of willingness to pay for each...

  1. A Business Goal Driven Approach for Understanding and Specifying Information Security Requirements

    NARCIS (Netherlands)

    Su, X.; Bolzoni, D.; van Eck, Pascal

    In this paper we present an approach for specifying and prioritizing information security requirements in organizations. It is important to prioritize security requirements since hundred per cent security is not achievable and the limited resources available should be directed to satisfy the most

  2. A positive deviance approach to understanding key features to improving diabetes care in the medical home

    NARCIS (Netherlands)

    Gabbay, R.A.; Friedberg, M.W.; Miller-Day, M.; Cronholm, P.F.; Adelman, A.; Schneider, E.C.

    2013-01-01

    PURPOSE The medical home has gained national attention as a model to reorganize primary care to improve health outcomes. Pennsylvania has undertaken one of the largest state-based, multipayer medical home pilot projects. We used a positive deviance approach to identify and compare factors driving

  3. The Integration of a Family Systems Approach for Understanding Youth Obesity, Physical Activity, and Dietary Programs

    Science.gov (United States)

    Kitzman-Ulrich, Heather; Wilson, Dawn K.; St. George, Sara M.; Lawman, Hannah; Segal, Michelle; Fairchild, Amanda

    2010-01-01

    Rates of overweight in youth have reached epidemic proportions and are associated with adverse health outcomes. Family-based programs have been widely used to treat overweight in youth. However, few programs incorporate a theoretical framework for studying a family systems approach in relation to youth health behavior change. Therefore, this…

  4. Plasmodium knowlesi transmission: integrating quantitative approaches from epidemiology and ecology to understand malaria as a zoonosis.

    Science.gov (United States)

    Brock, P M; Fornace, K M; Parmiter, M; Cox, J; Drakeley, C J; Ferguson, H M; Kao, R R

    2016-04-01

    The public health threat posed by zoonotic Plasmodium knowlesi appears to be growing: it is increasingly reported across South East Asia, and is the leading cause of malaria in Malaysian Borneo. Plasmodium knowlesi threatens progress towards malaria elimination as aspects of its transmission, such as spillover from wildlife reservoirs and reliance on outdoor-biting vectors, may limit the effectiveness of conventional methods of malaria control. The development of new quantitative approaches that address the ecological complexity of P. knowlesi, particularly through a focus on its primary reservoir hosts, will be required to control it. Here, we review what is known about P. knowlesi transmission, identify key knowledge gaps in the context of current approaches to transmission modelling, and discuss the integration of these approaches with clinical parasitology and geostatistical analysis. We highlight the need to incorporate the influences of fine-scale spatial variation, rapid changes to the landscape, and reservoir population and transmission dynamics. The proposed integrated approach would address the unique challenges posed by malaria as a zoonosis, aid the identification of transmission hotspots, provide insight into the mechanistic links between incidence and land use change and support the design of appropriate interventions.

  5. 'Omics' Approaches to Understanding Interstitial Cystitis/Painful Bladder Syndrome/Bladder Pain Syndrome

    Science.gov (United States)

    You, Sungyong; Yang, Wei; Anger, Jennifer T.; Freeman, Michael R.

    2012-01-01

    Recent efforts in the generation of large genomics, transcriptomics, proteomics, metabolomics and other types of 'omics' data sets have provided an unprecedentedly detailed view of certain diseases, however to date most of this literature has been focused on malignancy and other lethal pathological conditions. Very little intensive work on global profiles has been performed to understand the molecular mechanism of interstitial cystitis/painful bladder syndrome/bladder pain syndrome (IC/PBS/BPS), a chronic lower urinary tract disorder characterized by pelvic pain, urinary urgency and frequency, which can lead to long lasting adverse effects on quality of life. A lack of understanding of molecular mechanism has been a challenge and dilemma for diagnosis and treatment, and has also led to a delay in basic and translational research focused on biomarker and drug discovery, clinical therapy, and preventive strategies against IC/PBS/BPS. This review describes the current state of 'omics' studies and available data sets relevant to IC/PBS/BPS, and presents opportunities for new research directed at understanding the pathogenesis of this complex condition. PMID:23346481

  6. Extending the scope of Darwin's 'abominable mystery': integrative approaches to understanding angiosperm origins and species richness.

    Science.gov (United States)

    Katz, Ofir

    2018-01-25

    Angiosperms are the most species-rich group of land plants, but their origins and fast and intense diversification still require an explanation. Extending research scopes can broaden theoretical frameworks and lines of evidence that can lead to solving this 'abominable mystery'. Solutions lie in understanding evolutionary trends across taxa and throughout the Phanerozoic, and integration between hypotheses and ideas that are derived from multiple disciplines. Descriptions of evolutionary chronologies should integrate between molecular phylogenies, descriptive palaeontology and palaeoecology. New molecular chronologies open new avenues of research of possible Palaeozoic angiosperm ancestors and how they evolved during as many as 200Myr until the emergence of true angiosperms. The idea that 'biodiversity creates biodiversity' requires evidence from past and present ecologies, with changes in herbivory and resource availability throughout the Phanerozoic appearing to be particularly promising. Promoting our understanding of angiosperm origins and diversification in particular, and the evolution of biodiversity in general, requires more profound understanding of the ecological past through integrating taxonomic, temporal and ecological scopes. © The Author 2017. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  7. A Mixed-Methods Approach to Understanding Loneliness and Depression in Older Adults

    Science.gov (United States)

    Barg, Frances K.; Huss-Ashmore, Rebecca; Wittink, Marsha N.; Murray, Genevra F.; Bogner, Hillary R.; Gallo, Joseph J.

    2009-01-01

    Objectives Depression in late life may be difficult to identify, and older adults often do not accept depression treatment offered. This article describes the methods by which we combined an investigator-defined definition of depression with a person-derived definition of depression in order to understand how older adults and their primary care providers overlapped and diverged in their ideas about depression. Methods We recruited a purposive sample of 102 persons aged 65 years and older with and without significant depressive symptoms on a standardized assessment scale (Center for Epidemiologic Studies–Depression scale) from primary care practices and interviewed them in their homes. We applied methods derived from anthropology and epidemiology (consensus analysis, semi-structured interviews, and standardized assessments) in order to understand the experience and expression of late-life depression. Results Loneliness was highly salient to older adults whom we asked to describe a depressed person or themselves when depressed. Older adults viewed loneliness as a precursor to depression, as self-imposed withdrawal, or as an expectation of aging. In structured interviews, loneliness in the week prior to interview was highly associated with depressive symptoms, anxiety, and hopelessness. Discussion An improved understanding of how older adults view loneliness in relation to depression, derived from multiple methods, may inform clinical practice. PMID:17114313

  8. Dilemmas in the Analysis of Technological Change. A Cognitive Approach to Understand Innovation and Change in the Water Sector

    Directory of Open Access Journals (Sweden)

    Dino Borri

    2014-05-01

    Full Text Available In this paper we argue for the need to apply a cognitive approach to understand deep dynamics and determinants of technological evolutions. After examining main contributions from innovation studies to the conceptualization of innovation and change in complex socio-technical environments, we highlight the contribution coming from the application of the cognitive approach to evolutionary studies on technologies and we introduce the concept of technological memory as an interpretative tool to understand those changes. We discuss our hypothesis with reference to several observations carried out in different local contexts – Mexico, India and Italy – in relation to technological change in the water sector. In those cases deliberate attempts to substitute traditional technologies with modern ones led to interesting trajectories of change ranging from the collapse of old technologies to the development of multifaceted hybridization patterns.

  9. Understanding the intentional acoustic behavior of humpback whales: a production-based approach.

    Science.gov (United States)

    Cazau, Dorian; Adam, Olivier; Laitman, Jeffrey T; Reidenberg, Joy S

    2013-09-01

    Following a production-based approach, this paper deals with the acoustic behavior of humpback whales. This approach investigates various physical factors, which are either internal (e.g., physiological mechanisms) or external (e.g., environmental constraints) to the respiratory tractus of the whale, for their implications in sound production. This paper aims to describe a functional scenario of this tractus for the generation of vocal sounds. To do so, a division of this tractus into three different configurations is proposed, based on the air recirculation process which determines air sources and laryngeal valves. Then, assuming a vocal function (in sound generation or modification) for several specific anatomical components, an acoustic characterization of each of these configurations is proposed to link different spectral features, namely, fundamental frequencies and formant structures, to specific vocal production mechanisms. A discussion around the question of whether the whale is able to fully exploit the acoustic potential of its respiratory tractus is eventually provided.

  10. Virtual muscle: a computational approach to understanding the effects of muscle properties on motor control.

    Science.gov (United States)

    Cheng, E J; Brown, I E; Loeb, G E

    2000-09-15

    This paper describes a computational approach to modeling the complex mechanical properties of muscles and tendons under physiological conditions of recruitment and kinematics. It is embodied as a software package for use with Matlab and Simulink that allows the creation of realistic musculotendon elements for use in motor control simulations. The software employs graphic user interfaces (GUI) and dynamic data exchange (DDE) to facilitate building custom muscle model blocks and linking them to kinetic analyses of complete musculoskeletal systems. It is scalable in complexity and accuracy. The model is based on recently published data on muscle and tendon properties measured in feline slow- and fast-twitch muscle, and incorporates a novel approach to simulating recruitment and frequency modulation of different fiber-types in mixed muscles. This software is distributed freely over the Internet at http://ami.usc.edu/mddf/virtualmuscle.

  11. A comprehensive multiomics approach toward understanding the relationship between aging and dementia.

    Science.gov (United States)

    Currais, Antonio; Goldberg, Joshua; Farrokhi, Catherine; Chang, Max; Prior, Marguerite; Dargusch, Richard; Daugherty, Daniel; Armando, Aaron; Quehenberger, Oswald; Maher, Pamela; Schubert, David

    2015-11-01

    Because age is the greatest risk factor for sporadic Alzheimer's disease (AD), phenotypic screens based upon old age-associated brain toxicities were used to develop the potent neurotrophic drug J147. Since certain aspects of aging may be primary cause of AD, we hypothesized that J147 would be effective against AD-associated pathology in rapidly aging SAMP8 mice and could be used to identify some of the molecular contributions of aging to AD. An inclusive and integrative multiomics approach was used to investigate protein and gene expression, metabolite levels, and cognition in old and young SAMP8 mice. J147 reduced cognitive deficits in old SAMP8 mice, while restoring multiple molecular markers associated with human AD, vascular pathology, impaired synaptic function, and inflammation to those approaching the young phenotype. The extensive assays used in this study identified a subset of molecular changes associated with aging that may be necessary for the development of AD.

  12. Understanding the Nature of Bureaucracy: An Integration of the Organizational and Public Choice Approaches

    Science.gov (United States)

    1993-03-01

    between the physical and social sciences. As Friedrich Hayek points out, Vilfredo Pareto, a modern founder of mathematical economics, never intended to...Bawerk and Friedrich von Wieser, two students of Carl Menger. Mises continued to develop economics using the methodological approach of earlier economists...the coexistence and succession of observable phenomena ( Hayek , 1988:61). The 10 modern neoclassical tradition embraces a positivist-mathematical theory

  13. Towards a multidisciplinary approach to understand and manage obesity and related diseases

    OpenAIRE

    Bischoff, Stephan C; Boirie, Yves; Cederholm, Tommy; Chourdakis, Michael; Cuerda, Cristina; Delzenne, Nathalie M.; Deutz, Nicolaas E; Fouque, Denis; Genton, Laurence; Gil, Carmen; Koletzko, Berthold; Leon-Sanz, Miguel; Shamir, Raanan; Singer, Joelle; Singer, Pierre

    2016-01-01

    Overnutrition and sedentary lifestyle result in overweight or obesity defined as abnormal or excessive fat accumulation that may impair health. According to the WHO, the worldwide prevalence of obesity nearly doubled between 1980 and 2008. In 2008, over 50% of both men and women in the WHO European Region were overweight, and approximately 23% of women and 20% of men were obese. Comprehensive diagnostic and therapeutic approaches should include nutritional treatment to favor the best metaboli...

  14. A Discursive Institutionalist Approach to Understanding the Changes to the Irish Social Partnership Policy After 2008

    OpenAIRE

    Hogan, John; Timoney, Nicola

    2016-01-01

    Read before the society, 14 January 2016 Employing the critical juncture theory (CJT), a discursive institutionalist approach, this paper examines the nature of the changes to social partnership policy at the end of the decade of the 2000s. Did these changes constitute a transformation in social partnership policy, or were they a continuation of a previously established policy pathway? The CJT consists of three elements – economic crisis, ideational change, and the nature of the policy cha...

  15. To do good might hurt bad : Exploring nurses' understanding and approach to suffering in forensic psychiatric settings

    OpenAIRE

    Vincze, M.; Fredriksson, L.; Wiklund Gustin, Lena

    2015-01-01

    Patients in forensic psychiatric settings not only have to deal with their mental illness, but also memories of criminal activities and being involuntarily hospitalized. The aim of the present study was to explore how nurses working in forensic psychiatric services understand and approach patients' experiences of suffering. Data were generated by semistructured interviews with psychiatric nurses from two different forensic psychiatric units in Sweden. Data were analysed by means of a hermeneu...

  16. Understanding Contrasting Approaches to Nationwide Implementations of Electronic Health Record Systems: England, the USA and Australia

    Directory of Open Access Journals (Sweden)

    Zoe Morrison

    2011-01-01

    Full Text Available As governments commit to national electronic health record (EHR systems, there is increasing international interest in identifying effective implementation strategies. We draw on Coiera's typology of national programmes - ‘top-down’, ‘bottom-up’ and ‘middle-out’ - to review EHR implementation strategies in three exemplar countries: England, the USA and Australia. In comparing and contrasting three approaches, we show how different healthcare systems, national policy contexts and anticipated benefits have shaped initial strategies. We reflect on progress and likely developments in the face of continually changing circumstances. Our review shows that irrespective of the initial strategy, over time there is likely to be convergence on the negotiated, devolved middle-out approach, which aims to balance the interests and responsibilities of local healthcare constituencies and national government to achieve national connectivity. We conclude that, accepting the current lack of empirical evidence, the flexibility offered by the middle-out approach may make this the best initial national strategy.

  17. Understanding anorexia: an hermeneutic approach as a methodological alternative for the field of contemporary anorexia research

    Directory of Open Access Journals (Sweden)

    Anne Puuronen

    1999-01-01

    Full Text Available Theories of anorexia nervosa have mainly been dominated by psychiatry and concentrate upon its physiological aspects, both in diagnosis and treatment. This has led to a search for organic causes behind anorectic conditions, instead of seeing it as molded and shaped both by the individual and the socio-cultural context. This "medicalisation" has been an impediment to a more complete conceptualisation of the experience of discipline and of the ascetic modes of action in anorexia. The intension is to approach anorexia as lived process. The focus is not in explaining what cause anorexia, but is centered on the contents of living experience as such. Thus, the author proposes a phenomenological approach to anorexia as a methodological alternative compared to the dominant medico-psychological approaches to anorexia of today. If we consider the body of an anorectic person as an intersection in which the subject's relationship to social reality will be materialized and verified, we are able to see first how accurate a picture of the dual meanings, double bindings and paradoxical commitments of our present culture and its relation to a woman's body anorexia will draw up. Also, because the fact is that anorexia is a predominantly "women's" illness we have to take in account that the construction of subjectivity and in this context the construction of a lived anorectic experience of discipline, is not a gender-neutral process.

  18. Understanding the whole city as landscape. A multivariate approach to urban landscape morphology

    Directory of Open Access Journals (Sweden)

    Richard Stiles

    2014-05-01

    Full Text Available The European Landscape Convention implies a requirement for signatory states to identify their urban landscapes which goes beyond the traditional focus on individual parks and green spaces and the links between them. Landscape ecological approaches can provide a useful model for identifying urban landscape types across a whole territory, but the variables relevant for urban landscapes are very different to those usually addressing rural areas. This paper presents an approach to classifying the urban landscape of Vienna that was developed in a research project funded by the Austrian Ministry for Transport, Innovation and Technology: ‘Urban Fabric and Microclimate Response’. Nine landscape types and a number of sub-types were defined, using a multivariate statistical approach which takes account of both morphological and urban climate related variables. Although the variables were selected to objectively reflect the factors that could best represent the urban climatic characteristics of the urban landscape, the results also provided a widely plausible representation of the structure of the city’s landscapes. Selected examples of the landscape types that were defined in this way were used both to simulate current microclimatic conditions and also to model the effects of possible climatic amelioration measures. Finally the paper looks forward to developing a more general-purpose urban landscape typology that allows investigating a much broader complex of urban landscape functions.

  19. The Component Model of Infrastructure: A Practical Approach to Understanding Public Health Program Infrastructure

    Science.gov (United States)

    Snyder, Kimberly; Rieker, Patricia P.

    2014-01-01

    Functioning program infrastructure is necessary for achieving public health outcomes. It is what supports program capacity, implementation, and sustainability. The public health program infrastructure model presented in this article is grounded in data from a broader evaluation of 18 state tobacco control programs and previous work. The newly developed Component Model of Infrastructure (CMI) addresses the limitations of a previous model and contains 5 core components (multilevel leadership, managed resources, engaged data, responsive plans and planning, networked partnerships) and 3 supporting components (strategic understanding, operations, contextual influences). The CMI is a practical, implementation-focused model applicable across public health programs, enabling linkages to capacity, sustainability, and outcome measurement. PMID:24922125

  20. A problem-oriented approach to understanding adaptation: lessons learnt from Alpine Shire, Victoria Australia.

    Science.gov (United States)

    Roman, Carolina

    2010-05-01

    Climate change is gaining attention as a significant strategic issue for localities that rely on their business sectors for economic viability. For businesses in the tourism sector, considerable research effort has sought to characterise the vulnerability to the likely impacts of future climate change through scenarios or ‘end-point' approaches (Kelly & Adger, 2000). Whilst useful, there are few demonstrable case studies that complement such work with a ‘start-point' approach that seeks to explore contextual vulnerability (O'Brien et al., 2007). This broader approach is inclusive of climate change as a process operating within a biophysical system and allows recognition of the complex interactions that occur in the coupled human-environmental system. A problem-oriented and interdisciplinary approach was employed at Alpine Shire, in northeast Victoria Australia, to explore the concept of contextual vulnerability and adaptability to stressors that include, but are not limited to climatic change. Using a policy sciences approach, the objective was to identify factors that influence existing vulnerabilities and that might consequently act as barriers to effective adaptation for the Shire's business community involved in the tourism sector. Analyses of results suggest that many threats, including the effects climate change, compete for the resources, strategy and direction of local tourism management bodies. Further analysis of conditioning factors revealed that many complex and interacting factors define the vulnerability and adaptive capacity of the Shire's tourism sector to the challenges of global change, which collectively have more immediate implications for policy and planning than long-term future climate change scenarios. An approximation of the common interest, i.e. enhancing capacity in business acumen amongst tourism operators, would facilitate adaptability and sustainability through the enhancement of social capital in this business community. Kelly, P

  1. A multi-omics and imaging approach to understand soil organic matter composition and its interaction with microbes.

    Science.gov (United States)

    Tfaily, M. M.; Walker, L. R.; Kyle, J. E.; Chu, R. K.; Dohnalkova, A.; Tolic, N.; Orton, D.; Robinson, E. R.; Paša-Tolić, L.; Hess, N. J.

    2015-12-01

    The focus on soil C dynamics is currently relevant as researchers and policymakers strive to understand the feedbacks between ecosystem stress and climate change. Successful development of molecular profiles that link soil microbiology with soil carbon (C) dynamics to ascertain soil vulnerability and resilience to climate change would have great impact on assessments of soil ecosystems in response to climate change. Additionally, a better understanding of the soil C dynamics would improve climate modeling, and fate and transport of carbon across terrestrial, subsurface and atmospheric interfaces. Unravelling the wide range of possible interactions between and within the microbial communities, with minerals and organic compounds in the terrestrial ecosystem requires a multimodal, molecular approach. Here we report on the use of a combination of several molecular 'omics' approaches: metabolomics, metallomics, lipidomics, and proteomics coupled with a suite of high resolution imaging, and X-ray diffraction crystallographic techniques, as a novel methodology to understand SOM composition, and its interaction with microbial communities in different ecosystems, including C associated with mineral surfaces. The findings of these studies provide insights into the SOM persistence and microbial stabilization of carbon in ecosystems and reveal the powerful coupling of a multi-scale of techniques. Examples of this approach will be presented from field studies of simulated climate change, and laboratory column-grown Pinus resinosa mesocosms.

  2. New approach for cognitive analysis and understanding of medical patterns and visualizations

    Science.gov (United States)

    Ogiela, Marek R.; Tadeusiewicz, Ryszard

    2003-11-01

    This paper presents new opportunities for applying linguistic description of the picture merit content and AI methods to undertake tasks of the automatic understanding of images semantics in intelligent medical information systems. A successful obtaining of the crucial semantic content of the medical image may contribute considerably to the creation of new intelligent multimedia cognitive medical systems. Thanks to the new idea of cognitive resonance between stream of the data extracted from the image using linguistic methods and expectations taken from the representaion of the medical knowledge, it is possible to understand the merit content of the image even if teh form of the image is very different from any known pattern. This article proves that structural techniques of artificial intelligence may be applied in the case of tasks related to automatic classification and machine perception based on semantic pattern content in order to determine the semantic meaning of the patterns. In the paper are described some examples presenting ways of applying such techniques in the creation of cognitive vision systems for selected classes of medical images. On the base of scientific research described in the paper we try to build some new systems for collecting, storing, retrieving and intelligent interpreting selected medical images especially obtained in radiological and MRI examinations.

  3. Understanding energy-related regimes: A participatory approach from central Australia

    International Nuclear Information System (INIS)

    Foran, Tira; Fleming, David; Spandonide, Bruno; Williams, Rachel; Race, Digby

    2016-01-01

    For a particular community, what energy-related innovations constitute no-regrets strategies? We present a methodology to understand how alternative energy consuming activities and policy regimes impact on current and future liveability of socio-culturally diverse communities facing climate change. Our methodology augments the energy policy literature by harnessing three concepts (collaborative governance, innovation and political economic regime of provisioning) to support dialogue around changing energy-related activities. We convened workshops in Alice Springs, Australia to build capability to identify no-regrets energy-related housing or transport activities and strategies. In preparation, we interviewed policy actors and constructed three new housing-related future scenarios. After discussing the scenarios, policy and research actors prioritised five socio-technical activities or strategies. Evaluations indicate participants enjoyed opportunities given by the methodology to have focussed discussions about activities and innovation, while requesting more socially nuanced scenario storylines. We discuss implications for theory and technique development. - Highlights: •Energy-related activities and regimes frustrate pro-sustainability action. •Participatory workshops increased understanding of activities and regimes. •Workshops used a novel combination of governance and social theories. •Results justify inclusive dialogue around building energy standards and transport options.

  4. A translational neuroscience approach to understanding the development of social anxiety disorder and its pathophysiology.

    Science.gov (United States)

    Fox, Andrew S; Kalin, Ned H

    2014-11-01

    This review brings together recent research from molecular, neural circuit, animal model, and human studies to help understand the neurodevelopmental mechanisms underlying social anxiety disorder. Social anxiety disorder is common and debilitating, and it often leads to further psychopathology. Numerous studies have demonstrated that extremely behaviorally inhibited and temperamentally anxious young children are at marked risk of developing social anxiety disorder. Recent work in human and nonhuman primates has identified a distributed brain network that underlies early-life anxiety including the central nucleus of the amygdala, the anterior hippocampus, and the orbitofrontal cortex. Studies in nonhuman primates have demonstrated that alterations in this circuit are trait-like in that they are stable over time and across contexts. Notably, the components of this circuit are differentially influenced by heritable and environmental factors, and specific lesion studies have demonstrated a causal role for multiple components of the circuit. Molecular studies in rodents and primates point to disrupted neurodevelopmental and neuroplastic processes within critical components of the early-life dispositional anxiety neural circuit. The possibility of identifying an early-life at-risk phenotype, along with an understanding of its neurobiology, provides an unusual opportunity to conceptualize novel preventive intervention strategies aimed at reducing the suffering of anxious children and preventing them from developing further psychopathology.

  5. Genetic approaches to understanding the population-level impact of wind energy development on migratory bats

    Energy Technology Data Exchange (ETDEWEB)

    Vonhof, Maarten J. [Western Michigan Univ., Kalamazoo MI (United States); Russell, Amy L. [Grand Valley State Univ. Allendale, MI (United States)

    2013-09-30

    Documented fatalities of bats at wind turbines have raised serious concerns about the future impacts of increased wind power development on populations of migratory bat species. Yet there is little data on bat population sizes and trends to provide context for understanding the consequences of mortality due to wind power development. Using a large dataset of both nuclear and mitochondrial DNA variation for eastern red bats, we demonstrated that: 1) this species forms a single, panmictic population across their range with no evidence for the historical use of divergent migratory pathways by any portion of the population; 2) the effective size of this population is in the hundreds of thousands to millions; and 3) for large populations, genetic diversity measures and at least one coalescent method are insensitive to even very high rates of population decline over long time scales and until population size has become very small. Our data provide important context for understanding the population-level impacts of wind power development on affected bat species.

  6. DP 71 AND BETA DYSTROGLYCAN INTERACTION: A MOLECULAR MODELING APPROACH TO UNDERSTAND DUCHENNE MUSCULAR DYSTROPHY

    Directory of Open Access Journals (Sweden)

    Simanti Bhattacharya,

    2013-12-01

    Full Text Available Dp 71 is the most prevalent and widely expressed non muscle isoform of dystrophin (Dp and its mutations are associated with Duchenne muscular dystrophy, a severe form of muscular disorder. Dp 71 deviates from the canonical Dp by means of its truncated N terminal which also has abolished certain amino acids that comprise WW domain in the canonical form. This WW domain is very crucial for Dp’s interaction with partner proteins to establish a bridge between extra cellular matrices and cellular cytoskeleton. In our current study we have employed molecular modeling technique to understand the structural architecture of the N terminal region of Dp 71 and its deviation from the canonical form. We have further extended our studies to analyze the interaction probabilities between Dp 71 and β-DG applying molecular docking. Our studies for the first time have revealed that in spite of the underlying differences in terms of amino acids and structural organization, Dp 71 can interact with β-DG with its N terminal region which shares the similar molecular surface with the canonical form of Dp. These findings have opened up a platform to investigate the molecular interactions, spatio temporal orientations of the amino acids of Dp 71 and β-DG to understand the onset of DMD in much more greater detail

  7. Game-as-Teacher: Modification by Adaptation in Learning through Game-Play

    Science.gov (United States)

    Hopper, Tim

    2011-01-01

    This paper will explore how game-play in video games as well as game centered approaches in physical education (PE) such as Teaching Games for Understanding (TGfU) can draw on complexity thinking to inform the learning process in physical education. Using the video game concept of game-as-teacher (Gee, 2007), ideas such as enabling constraints…

  8. Towards a multidisciplinary approach to understand and manage obesity and related diseases.

    Science.gov (United States)

    Bischoff, Stephan C; Boirie, Yves; Cederholm, Tommy; Chourdakis, Michael; Cuerda, Cristina; Delzenne, Nathalie M; Deutz, Nicolaas E; Fouque, Denis; Genton, Laurence; Gil, Carmen; Koletzko, Berthold; Leon-Sanz, Miguel; Shamir, Raanan; Singer, Joelle; Singer, Pierre; Stroebele-Benschop, Nanette; Thorell, Anders; Weimann, Arved; Barazzoni, Rocco

    2017-08-01

    Overnutrition and sedentary lifestyle result in overweight or obesity defined as abnormal or excessive fat accumulation that may impair health. According to the WHO, the worldwide prevalence of obesity nearly doubled between 1980 and 2008. In 2008, over 50% of both men and women in the WHO European Region were overweight, and approximately 23% of women and 20% of men were obese. Comprehensive diagnostic and therapeutic approaches should include nutritional treatment to favor the best metabolic and nutritional outcome, as well as to induce potential disease-specific benefits from selected nutritional regimens. Obesity is usually accompanied by an increased muscle mass. This might explain why obesity, under particular circumstances such as cancer or high age, might have protective effects, a phenomenon named the 'obesity paradox'. However, loss of muscle mass or function can also occur, which is associated with poor prognosis and termed 'sarcopenic obesity'. Therefore, treatment recommendations may need to be individualized and adapted to co-morbidities. Since obesity is a chronic systemic disease it requires a multidisciplinary approach, both at the level of prevention and therapy including weight loss and maintenance. In the present personal review and position paper, authors from different disciplines including endocrinology, gastroenterology, nephrology, pediatrics, surgery, geriatrics, intensive care medicine, psychology and psychiatry, sports medicine and rheumatology, both at the basic science and clinical level, present their view on the topic and underline the necessity to provide a multidisciplinary approach, to address this epidemic. Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  9. Human organomics: a fresh approach to understanding human development using single-cell transcriptomics.

    Science.gov (United States)

    Camp, J Gray; Treutlein, Barbara

    2017-05-01

    Innovative methods designed to recapitulate human organogenesis from pluripotent stem cells provide a means to explore human developmental biology. New technologies to sequence and analyze single-cell transcriptomes can deconstruct these 'organoids' into constituent parts, and reconstruct lineage trajectories during cell differentiation. In this Spotlight article we summarize the different approaches to performing single-cell transcriptomics on organoids, and discuss the opportunities and challenges of applying these techniques to generate organ-level, mechanistic models of human development and disease. Together, these technologies will move past characterization to the prediction of human developmental and disease-related phenomena. © 2017. Published by The Company of Biologists Ltd.

  10. Understanding price discovery in interconnected markets: Generalized Langevin process approach and simulation

    Science.gov (United States)

    Schenck, Natalya A.; Horvath, Philip A.; Sinha, Amit K.

    2018-02-01

    While the literature on price discovery process and information flow between dominant and satellite market is exhaustive, most studies have applied an approach that can be traced back to Hasbrouck (1995) or Gonzalo and Granger (1995). In this paper, however, we propose a Generalized Langevin process with asymmetric double-well potential function, with co-integrated time series and interconnected diffusion processes to model the information flow and price discovery process in two, a dominant and a satellite, interconnected markets. A simulated illustration of the model is also provided.

  11. How can the capability approach contribute to understanding provision for people with learning difficulties?

    OpenAIRE

    Florian, Lani; Devecchi, Cristina; Dee, Lesley

    2008-01-01

    The capability approach suggests that well-being is fundamentally about the freedom that people have to be and do the things they have reason to value. This paper asks what freedom those adults who experience difficulties in learning have to be and do the things they have reason to value? It draws upon our recently completed literature review on theories of learning for adults with difficulties in learning (Dee, Devecchi and Florian, 2006) where the concepts of ‘being’ and ‘doing’ were integr...

  12. Icepod Plus Potential Field: An Integrated Approach For Understanding Ice Shelf Processes

    Science.gov (United States)

    Frearson, N.

    2015-12-01

    Warm water flowing beneath the large floating ice shelves in Antarctica will play an important role in how fast sea level rises. The lack of detailed bathymetry beneath the large ice shelves and lack of understanding of their internal structure inherently limits our knowledge of how ice shelves will thin and collapse. Understanding the bathymetry beneath the remaining ice shelves is critical to understanding how ice shelves will thin in the future and how that will impact the flux of ice into the global ocean. The Ross Ice Shelf, the largest ice shelf remaining on our planet, buttresses the West Antarctic Ice Sheet. The bathymetry beneath the Ross Ice Shelf is the least explored piece of ocean floor on our planet. The IcePod is a compact integrated ice imaging system developed for use on any C-130 aircraft developed with NSF support. The initial development program was targeted towards investigating glacial and ice-sheet processes. In this program, deep and shallow ice radars were developed. Optical instruments, including a scanning laser, Infra-red camera and visible wave camera were integrated into the pod. We have expanded the IcePod instrument suite to include the potential field measurements of magnetic and gravity anomalies with support from the Moore Foundation. During the development, a total field cesium sensor magnetometer and 3-axis fluxgate from previously funded work were also incorporated into the pod. Their behavioral response to being located close to high-frequency electronics, power supplies and metallic objects were studied. We describe in part some of that development process and the positive findings that resulted. The Icepod group is also actively pursuing the development, modification and incorporation of a new gravimeter into the suite of instruments available to the program and is investigating reduction in size of this that may eventually lead to incorporating the gravimeter into the pod itself. As part of this program we are also

  13. Understanding territorial distribution of Properties of Managers and Shareholders: a Data-driven Approach

    Directory of Open Access Journals (Sweden)

    Stefano Pozzati

    2016-12-01

    Full Text Available The analysis and better understanding of the distribution of wealth of individuals in cities can be a precious tool, especially in support of the estimation of real estate values. These analyses can also be used to facilitate decision making in various sectors, such as public administration or the real estate market. In this paper, by making use of publicly available data and of data owned by Cerved, (a credit scoring company in Italy, we can observe the territorial distribution of the properties of managers and shareholders – categories of people usually linked to high economic well-being – and, based on that, we identify the areas of the cities where the value of real estate properties is presumably higher. More specifically, we introduce the Manager and Shareholder Concentration (MSHC score and validate its accuracy and effectiveness in three Italian cities (Turin, Rome and Milan.

  14. Computational Approaches to Understand Transcriptional Regulation and Alternative Promoter Usage in Mammals

    DEFF Research Database (Denmark)

    Jørgensen, Mette

    understand and cure diseases. The focus of this thesis is transcriptional regulation. The main aim was to gain new insight into transcriptional regulation but a secondary goal was to develop new bioinformatic methods to facilitate future research. Three di erent studies are presented each focusing on di...... into proteins. All cells need di erent proteins in di erent amounts to function properly. The transcription and translation are therefore highly regulated and the regulation is not fully understood. It is important to learn as much as possible about both transcriptional and translational regulation to better...... erent aspects of transcriptional regulation. In the rst study we develop a machine learning framework to predict mRNA production, stalling and elongation of RNA polymerase II using publicly available histone modi cation data. The study reveals new pieces of information about the histone code. Besides...

  15. Understanding phase contrast MR angiography a practical approach with Matlab examples

    CERN Document Server

    Suresh Paul, Joseph

    2016-01-01

    Providing many unique MATLAB codes and functions throughout, this book covers the basics of Magnetic Resonance Imaging (MRI), leading to an in-depth understanding of the concepts and tools required for analysis and interpretation of Phase Contrast MR Angiography (PC-MRA). The concept of PC-MRA is often difficult, but essential for practicing engineers and scientists working in MR related areas. The concepts are better understood by uniquely combining the physical principles of fluid flow and MR imaging, laid out by modeling the theory and applications using a commonly used software tool MATLAB®. The book starts with a detailed theory of PC-MRA followed by a description of various image processing methods, including detailed MATLAB codes used for their implementation. The flow concepts in the context of MR imaging are explained using MATLAB based simulations.

  16. Social Return on Investment: A New Approach to Understanding and Advocating for Value in Healthcare.

    Science.gov (United States)

    Laing, Catherine M; Moules, Nancy J

    2017-12-01

    To determine whether the methodology of social return on investment (SROI) could be a way in which the value of a healthcare-related program (children's cancer camp) could be captured, evaluated, and communicated. The value of healthcare goes beyond what can be captured in financial terms; however, this is the most common type of value that is measured. The SROI methodology accounts for a broader concept of value by measuring social, environmental, and economic outcomes and uses monetary values to represent them. The steps/stages of an SROI analysis were applied to the context of a children's camp for this article. Applying the SROI methodology to this healthcare-related program was feasible and provided insight and understanding related to the impacts of this program. Because of SROI's flexibility, it is a tool that has great potential in a healthcare environment and for leaders to evaluate programmatic return on investment.

  17. Understanding the impact of political violence in childhood: a theoretical review using a social identity approach.

    Science.gov (United States)

    Muldoon, Orla T

    2013-12-01

    The present paper reviews the literature that has assessed the psychological impact of political violence on children. Concern for those growing up in situations of political violence has resulted in two areas of research within psychology: the first considers children as victims of conflict and considers the mental health consequences of political violence. The second considers children as protagonists or aggressors in conflict and considers related moral and attitudinal consequences of exposure to political violence. These two literatures are most often considered separately. Here the two strands of research are brought together using a social identity framework, allowing apparently divergent findings to be integrated into a more coherent understanding of the totality of consequences for children and young people growing up in situations of armed conflict. © 2013.

  18. Toward understanding the evolution of vertebrate gene regulatory networks: comparative genomics and epigenomic approaches.

    Science.gov (United States)

    Martinez-Morales, Juan R

    2016-07-01

    Vertebrates, as most animal phyla, originated >500 million years ago during the Cambrian explosion, and progressively radiated into the extant classes. Inferring the evolutionary history of the group requires understanding the architecture of the developmental programs that constrain the vertebrate anatomy. Here, I review recent comparative genomic and epigenomic studies, based on ChIP-seq and chromatin accessibility, which focus on the identification of functionally equivalent cis-regulatory modules among species. This pioneer work, primarily centered in the mammalian lineage, has set the groundwork for further studies in representative vertebrate and chordate species. Mapping of active regulatory regions across lineages will shed new light on the evolutionary forces stabilizing ancestral developmental programs, as well as allowing their variation to sustain morphological adaptations on the inherited vertebrate body plan. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  19. Traveling with blindness: A qualitative space-time approach to understanding visual impairment and urban mobility.

    Science.gov (United States)

    Wong, Sandy

    2018-01-01

    This paper draws from Hägerstrand's space-time framework to generate new insights on the everyday mobilities of individuals with visual impairments in the San Francisco Bay Area. While existing research on visual impairment and mobility emphasizes individual physical limitations resulting from vision loss or inaccessible public spaces, this article highlights and bridges both the behavioral and social processes that influence individual mobility. A qualitative analysis of sit-down and mobile interview data reveals that the space-time constraints of people with visual impairments are closely linked to their access to transportation, assistive technologies, and mobile devices. The findings deepen our understandings of the relationship between health and mobility, and present intervention opportunities for improving the quality of life for people with visual impairment. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Understanding Student Approaches to Learning Evolution in the Context of their Perceptions of the Relationship between Science and Religion

    Science.gov (United States)

    Yasri, Pratchayapong; Mancy, Rebecca

    2014-01-01

    This study investigates a range of positions that learners take on the relationship between science and religion and the potential for these positions to explain student approaches when learning about evolution. A phenomenographic study based on interviews with nine students studying in Christian high schools in Thailand led to the identification of five distinct positions on the relationship between science and religion. Each position was associated with a characteristic pattern of learning about evolution that could be explained as an attempt by the students to align their particular learning approach with their position. Three of the positions have the potential to support scientifically valid understandings of evolution while avoiding emotional conflict. We suggest that knowledge of the range of positions and associated learning approaches can help educators to focus on the form and timing of support of benefit to those holding different viewpoints.

  1. An in silico modeling approach to understanding the dynamics of sarcoidosis.

    Directory of Open Access Journals (Sweden)

    Baltazar D Aguda

    Full Text Available BACKGROUND: Sarcoidosis is a polygenic disease with diverse phenotypic presentations characterized by an abnormal antigen-mediated Th1 type immune response. At present, progress towards understanding sarcoidosis disease mechanisms and the development of novel treatments is limited by constraints attendant to conducting human research in a rare disease in the absence of relevant animal models. We sought to develop a computational model to enhance our understanding of the pathological mechanisms of and predict potential treatments of sarcoidosis. METHODOLOGY/RESULTS: Based upon the literature, we developed a computational model of known interactions between essential immune cells (antigen-presenting macrophages, effector and regulatory T cells and cytokine mediators (IL-2, TNFα, IFNγ of granulomatous inflammation during sarcoidosis. The dynamics of these interactions are described by a set of ordinary differential equations. The model predicts bistable switching behavior which is consistent with normal (self-limited and "sarcoidosis-like" (sustained activation of the inflammatory components of the system following a single antigen challenge. By perturbing the influence of model components using inhibitors of the cytokine mediators, distinct clinically relevant disease phenotypes were represented. Finally, the model was shown to be useful for pre-clinical testing of therapies based upon molecular targets and dose-effect relationships. CONCLUSIONS/SIGNIFICANCE: Our work illustrates a dynamic computer simulation of granulomatous inflammation scenarios that is useful for the investigation of disease mechanisms and for pre-clinical therapeutic testing. In lieu of relevant in vitro or animal surrogates, our model may provide for the screening of potential therapies for specific sarcoidosis disease phenotypes in advance of expensive clinical trials.

  2. New approach to the understanding of keloid: psychoneuroimmune–endocrine aspects

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    Hochman B

    2015-02-01

    Full Text Available Bernardo Hochman†, Felipe Contoli Isoldi, Fabianne Furtado, Lydia Masako Ferreira Plastic Surgery Division, Federal University of São Paulo, São Paulo, Brazil †Bernardo Hochman passed away on April 21, 2014 Abstract: The skin is a dynamic and complex organ that relies on the interrelation among different cell types, macromolecules, and signaling pathways. Further, the skin has interactions with its own appendages and other organs such as the sebaceous glands and hair follicles, the kidney, and adrenal glands; systems such as the central nervous system; and axes such as the hypothalamic–pituitary–adrenal axis. These continuous connections give the skin its versatility, and when an injury is caused, some triggers start a cascade of events designed to restore its integrity. Nowadays, it is known that this psychoneuroimmune–endocrine intercommunication modulates both the homeostatic condition and the healing process. In this sense, the skin conditions before a trauma, whether of endogenous (acne or exogenous origin (injury or surgical incision, could regulate the process of tissue repair. Most skin diseases such as psoriasis and atopic dermatitis, among others, have in their pathophysiology a psychogenic component that triggers integrated actions in the nervous, immune, and endocrine systems. However, fibroproliferative disorders of wound healing, such as hypertrophic scar and keloid, are not yet included in this listing, despite showing correlation with stress, especially with the psychosocial character. This review, by understanding the "brain–skin connection", presents evidence that allows us to understand the keloid as a psychomediated disease. Keywords: keloid, stress, psychological, psychoneuroimmunology, wound healing

  3. Understanding Appearance-Enhancing Drug Use in Sport Using an Enactive Approach to Body Image.

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    Hauw, Denis; Bilard, Jean

    2017-01-01

    From an enactive approach to human activity, we suggest that the use of appearance-enhancing drugs is better explained by the sense-making related to body image rather than the cognitive evaluation of social norms about appearance and consequent psychopathology-oriented approach. After reviewing the main psychological disorders thought to link body image issues to the use of appearance-enhancing substances, we sketch a flexible, dynamic and embedded account of body image defined as the individual's propensity to act and experience in specific situations. We show how this enacted body image is a complex process of sense-making that people engage in when they are trying to adapt to specific situations. These adaptations of the enacted body image require effort, perseverance and time, and therefore any substance that accelerates this process appears to be an easy and attractive solution. In this enactive account of body image, we underline that the link between the enacted body image and substance use is also anchored in the history of the body's previous interactions with the world. This emerges during periods of upheaval and hardship, especially in a context where athletes experience weak participatory sense-making in a sport community. We conclude by suggesting prevention and intervention designs that would promote a safe instrumental use of the body in sports and psychological helping procedures for athletes experiencing difficulties with substances use and body image.

  4. Process, institutional and organizational approaches in sociological understanding of educational system

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    M. V. Klyov

    2016-10-01

    Full Text Available The article draws attention to the nature and characteristics of culture­centric, process, institutional and organizational approaches to form the essence of the educational process as a whole. The author examines the university not only as an educational and scientific center, but also as a spiritual center, forming a new type of professional identity. It is noted that as a social phenomenon, process and social institution, education makes social changes in society, and the transparent nature of social processes, the dominance of market relations in turn affect the educational institute. However, the institutional approach makes it possible to consider the educational processes on social, and personal levels. It is observed that the institutionalization of higher education as a particular social institution within the entire social institution of education occurred in the second half of the twentieth century, which allowed to talk about the leading role of universities in modern culture. The author stresses that the theory of higher education is the widely recognized thesis that has multiple arguments. They are governed by national law based on national finance, train specialists for the national economy. In fact, the emergence of new forms of relationships is a positive social process, but there are also negative effects. Their premise, according to some researchers, was globalization, the effect of «market forces» that contribute to the development of «a world without borders».

  5. The preparatory set: A novel approach to understanding "stress", trauma, and the bodymind therapies

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    Peter ePayne

    2015-04-01

    Full Text Available Basic to all motile life is a differential approach/avoid response to perceived features of environment. The stages of response are initial reflexive noticing and orienting to the stimulus, preparation, and execution of response. Preparation involves a coordination of many aspects of the organism: muscle tone, posture, breathing, autonomic functions, motivational/emotional state, attentional orientation and expectations. The organism organizes itself in relation to the challenge. We propose to call this the preparatory set (PS. We suggest that the concept of the PS can offer a more nuanced and flexible perspective on the stress response than do current theories. We also hypothesize that the mechanisms of bodymind therapeutic and educational systems (BTES can be understood through the PS framework. We suggest that the BTES, including meditative movement, meditation, somatic education, and the body-oriented psychotherapies, are approaches that use interventions on the PS to remedy stress and trauma. We discuss how the PS can be adaptive or maladaptive, how BTES interventions may restore adaptive PS, and how these concepts offer a broader and more flexible view of the phenomena of stress and trauma. We offer supportive evidence for our hypotheses, and suggest directions for future research. We believe that the PS framework will point to ways of improving the management of stress and trauma, and that it will suggest directions of research into the mechanisms of action of BTES.

  6. Water Pollution Control Legislation in Israel: Understanding Implementation Processes from an Actor-Centered Approach

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    Sharon Hophmayer-Tokich

    2013-09-01

    Full Text Available In the State of Israel, advanced legislation for the management of scarce water resources, including legislation to prevent water pollution, were put in place in the early stages of the State’s formation. Despite that, on-going uncontrolled pollution has deteriorated the quality of water sources for decades, with the main source of pollution being untreated or partially treated domestic wastewater. This has been mainly the result of lack of enforcement of the existing laws. During the 1990s and onwards, a shift to forceful enforcement has been observed and wastewater treatment substantially improved. The paper analyzes the implementation processes of the pollution control legislations (the lack-of and the shift to forceful enforcement based on an actor-centered approach, using the contextual interaction theory.

  7. Understanding the individual to implement the ecosystem approach to fisheries management

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    Ward, Taylor D.; Algera, Dirk A.; Gallagher, Austin J.; Hawkins, Emily; Horodysky, Andrij; Jørgensen, Christian; Killen, Shaun S.; McKenzie, David J.; Metcalfe, Julian D.; Peck, Myron A.; Vu, Maria; Cooke, Steven J.

    2016-01-01

    Ecosystem-based approaches to fisheries management (EAFMs) have emerged as requisite for sustainable use of fisheries resources. At the same time, however, there is a growing recognition of the degree of variation among individuals within a population, as well as the ecological consequences of this variation. Managing resources at an ecosystem level calls on practitioners to consider evolutionary processes, and ample evidence from the realm of fisheries science indicates that anthropogenic disturbance can drive changes in predominant character traits (e.g. size at maturity). Eco-evolutionary theory suggests that human-induced trait change and the modification of selective regimens might contribute to ecosystem dynamics at a similar magnitude to species extirpation, extinction and ecological dysfunction. Given the dynamic interaction between fisheries and target species via harvest and subsequent ecosystem consequences, we argue that individual diversity in genetic, physiological and behavioural traits are important considerations under EAFMs. Here, we examine the role of individual variation in a number of contexts relevant to fisheries management, including the potential ecological effects of rapid trait change. Using select examples, we highlight the extent of phenotypic diversity of individuals, as well as the ecological constraints on such diversity. We conclude that individual phenotypic diversity is a complex phenomenon that needs to be considered in EAFMs, with the ultimate realization that maintaining or increasing individual trait diversity may afford not only species, but also entire ecosystems, with enhanced resilience to environmental perturbations. Put simply, individuals are the foundation from which population- and ecosystem-level traits emerge and are therefore of central importance for the ecosystem-based approaches to fisheries management. PMID:27293757

  8. Probabilistic Interval Forecasts: An Individual Differences Approach to Understanding Forecast Communication

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    Margaret A. Grounds

    2017-01-01

    Full Text Available Predictive interval forecasts, showing a range of values with specified probability, have the potential to improve decisions compared to point estimates. The research reported here demonstrates that this advantage extends from college undergraduates to a wide user group and does not depend on education. In two experiments, participants made decisions based on predictive intervals or point estimates and answered questions about them. In Experiment 1, they also completed numeracy and working memory span tests. Those using predictive intervals were better able to identify situations requiring precautionary action. Nonetheless, two errors were noted: (1 misinterpreting predictive intervals as diurnal fluctuation (deterministic construal errors and (2 judging the probability of events within and beyond the interval, when asked about them separately, as greater than 100%. These errors were only partially explained by WMS and numeracy. Importantly, omitting visualizations eliminated deterministic construal errors and overestimation of percent chance was not consistently related to decision quality. Thus, there may be important benefits to predictive interval forecasts that are not dependent on a full understanding of the theoretical principles underlying them or an advanced education, making them appropriate for a broad range of users with diverse backgrounds, weather concerns, and risk tolerances.

  9. Understanding why low-risk patients accept vaccines: a socio-behavioral approach.

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    Wiemken, Timothy L; Carrico, Ruth M; Kelley, Robert R; Binford, Laura E; Peyrani, Paula; Ford, Kimbal D; Welch, Verna; Ramirez, Julio A

    2015-12-23

    Vaccines are one of the most important public health interventions. Understanding factors associated with vaccine acceptance is critical. The objectives of this study were to evaluate the impact of the three constructs of the Theory of Planned Behavior (TPB) on the intention to be vaccinated among healthy individuals being seen for pre-travel care, and to evaluate if behavioral intention was associated with vaccine acceptance. We surveyed individuals seeking vaccination at the University of Louisville Vaccine and International Health and Travel Clinic. Linear and two stage least squares regression models were used to define the associations between constructs of the TPB and the intention to be vaccinated, as well as the association between the intention to be vaccinated and vaccine acceptance. A total of 183 individuals were included in the analysis. None of the constructs of the TPB were associated with intention to be vaccinated. Behavioral intention was not associated with vaccination acceptance. This study suggests that the TPB does not predict the intention to get vaccinated among individuals attending our Vaccine and International Health and Travel Clinic. It will be critical to define better predictors of vaccine uptake in healthy, low-risk individuals to increase vaccine acceptance.

  10. Understanding Democracy and Development Traps Using a Data-Driven Approach.

    Science.gov (United States)

    Ranganathan, Shyam; Nicolis, Stamatios C; Spaiser, Viktoria; Sumpter, David J T

    2015-03-01

    Methods from machine learning and data science are becoming increasingly important in the social sciences, providing powerful new ways of identifying statistical relationships in large data sets. However, these relationships do not necessarily offer an understanding of the processes underlying the data. To address this problem, we have developed a method for fitting nonlinear dynamical systems models to data related to social change. Here, we use this method to investigate how countries become trapped at low levels of socioeconomic development. We identify two types of traps. The first is a democracy trap, where countries with low levels of economic growth and/or citizen education fail to develop democracy. The second trap is in terms of cultural values, where countries with low levels of democracy and/or life expectancy fail to develop emancipative values. We show that many key developing countries, including India and Egypt, lie near the border of these development traps, and we investigate the time taken for these nations to transition toward higher democracy and socioeconomic well-being.

  11. Ad cerebrum per scientia: Ira Hirsh, psychoacoustics, and new approaches to understanding the human brain

    Science.gov (United States)

    Lauter, Judith

    2002-05-01

    As Research Director of CID, Ira emphasized the importance of combining information from biology with rigorous studies of behavior, such as psychophysics, to better understand how the brain and body accomplish the goals of everyday life. In line with this philosophy, my doctoral dissertation sought to explain brain functional asymmetries (studied with dichotic listening) in terms of the physical dimensions of a library of test sounds designed to represent a speech-music continuum. Results highlighted individual differences plus similarities in terms of patterns of relative ear advantages, suggesting an organizational basis for brain asymmetries depending on physical dimensions of stimulus and gesture with analogs in auditory, visual, somatosensory, and motor systems. My subsequent work has employed a number of noninvasive methods (OAEs, EPs, qEEG, PET, MRI) to explore the neurobiological bases of individual differences in general and functional asymmetries in particular. This research has led to (1) the AXS test battery for assessing the neurobiology of human sensory-motor function; (2) the handshaking model of brain function, describing dynamic relations along all three body/brain axes; (3) the four-domain EPIC model of functional asymmetries; and (4) the trimodal brain, a new model of individual differences based on psychoimmunoneuroendocrinology.

  12. Understanding the mechanisms of secondary nucleation for protein aggregation: an analytical approach

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    Michaels, Thomas; Knowles, Tuomas P. J.

    2013-03-01

    Filamentous protein self-assembly is a general type of behaviour accessible to a wide range of different polypeptide sequences. This phenomenon underlies key molecular events both in normal and aberrant biology, but a general theory of the crucial nucleation steps that govern this process has remained elusive. In this talk we discuss our attempts to provide a general description of secondary nucleation in filamentous protein assembly based on the Becker-Döring kinetic scheme to describe cluster-catalytic effects. This systematic procedure allows extracting low-dimensional systems of equations out of the full kinetic model, in a master equation formalism typically consisting of infinitely many coupled non-linear equations. Using this procedure, we propose and discuss various mechanisms that can underlie the secondary nucleation process. Using data curve-fitting and analysis we show that the addition of a monomer to heterogeneous nuclei is effectively irreversible and discuss the implications of our framework for the more general understanding of the physics of multi-step nucleation phenomena in nature.

  13. Gun possession among American youth: a discovery-based approach to understand gun violence.

    Science.gov (United States)

    Ruggles, Kelly V; Rajan, Sonali

    2014-01-01

    To apply discovery-based computational methods to nationally representative data from the Centers for Disease Control and Preventions' Youth Risk Behavior Surveillance System to better understand and visualize the behavioral factors associated with gun possession among adolescent youth. Our study uncovered the multidimensional nature of gun possession across nearly five million unique data points over a ten year period (2001-2011). Specifically, we automated odds ratio calculations for 55 risk behaviors to assemble a comprehensive table of associations for every behavior combination. Downstream analyses included the hierarchical clustering of risk behaviors based on their association "fingerprint" to 1) visualize and assess which behaviors frequently co-occur and 2) evaluate which risk behaviors are consistently found to be associated with gun possession. From these analyses, we identified more than 40 behavioral factors, including heroin use, using snuff on school property, having been injured in a fight, and having been a victim of sexual violence, that have and continue to be strongly associated with gun possession. Additionally, we identified six behavioral clusters based on association similarities: 1) physical activity and nutrition; 2) disordered eating, suicide and sexual violence; 3) weapon carrying and physical safety; 4) alcohol, marijuana and cigarette use; 5) drug use on school property and 6) overall drug use. Use of computational methodologies identified multiple risk behaviors, beyond more commonly discussed indicators of poor mental health, that are associated with gun possession among youth. Implications for prevention efforts and future interdisciplinary work applying computational methods to behavioral science data are described.

  14. An Approach for Understanding and Promoting Coal Mine Safety by Exploring Coal Mine Risk Network

    Directory of Open Access Journals (Sweden)

    Yongliang Deng

    2017-01-01

    Full Text Available Capturing the interrelations among risks is essential to thoroughly understand and promote coal mining safety. From this standpoint, 105 risks and 135 interrelations among risks had been identified from 126 typical accidents, which were also the foundation of constructing coal mine risk network (CMRN. Based on the complex network theory and Pajek, six parameters (i.e., network diameter, network density, average path length, degree, betweenness, and clustering coefficient were employed to reveal the topological properties of CMRN. As indicated by the results, CMRN possesses scale-free network property because its cumulative degree distribution obeys power-law distribution. This means that CMRN is robust to random hazard and vulnerable to deliberate attack. CMRN is also a small-world network due to its relatively small average path length as well as high clustering coefficient, implying that accident propagation in CMRN is faster than regular network. Furthermore, the effect of risk control is explored. According to the result, it shows that roof collapse, fire, and gas concentration exceeding limit refer to three most valuable targets for risk control among all the risks. This study will help offer recommendations and proposals for making beforehand strategies that can restrain original risks and reduce accidents.

  15. Long-term analysis of Zostera noltei: A retrospective approach for understanding seagrasses' dynamics.

    Science.gov (United States)

    Calleja, Felipe; Galván, Cristina; Silió-Calzada, Ana; Juanes, José A; Ondiviela, Bárbara

    2017-09-01

    Long-term studies are necessary to establish trends and to understand seagrasses' spatial and temporal dynamic. Nevertheless, this type of research is scarce, as the required databases are often unavailable. The objectives of this study are to create a method for mapping the seagrass Zostera noltei using remote sensing techniques, and to apply it to the characterization of the meadows' extension trend and the potential drivers of change. A time series was created using a novel method based on remote sensing techniques that proved to be adequate for mapping the seagrass in the emerged intertidal. The meadows seem to have a decreasing trend between 1984 and the early 2000s, followed by an increasing tendency that represents a recovery in the extension area of the species. This 30-year analysis demonstrated the Z. noltei's recovery in the study site, similar to that in other estuaries nearby and contrary to the worldwide decreasing behavior of seagrasses. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. A transdisciplinary approach to understanding the health effects of wildfire and prescribed fire smoke regimes

    Science.gov (United States)

    Williamson, G. J.; Bowman, D. M. J. S.; Price, O. F.; Henderson, S. B.; Johnston, F. H.

    2016-12-01

    Prescribed burning is used to reduce the occurrence, extent and severity of uncontrolled fires in many flammable landscapes. However, epidemiologic evidence of the human health impacts of landscape fire smoke emissions is shaping fire management practice through increasingly stringent environmental regulation and public health policy. An unresolved question, critical for sustainable fire management, concerns the comparative human health effects of smoke from wild and prescribed fires. Here we review current knowledge of the health effects of landscape fire emissions and consider the similarities and differences in smoke from wild and prescribed fires with respect to the typical combustion conditions and fuel properties, the quality and magnitude of air pollution emissions, and the potential for dispersion to large populations. We further examine the interactions between these considerations, and how they may shape the longer term smoke regimes to which populations are exposed. We identify numerous knowledge gaps and propose a conceptual framework that describes pathways to better understanding of the health trade-offs of prescribed and wildfire smoke regimes.

  17. Understanding Democracy and Development Traps Using a Data-Driven Approach

    Science.gov (United States)

    Ranganathan, Shyam; Nicolis, Stamatios C.; Spaiser, Viktoria; Sumpter, David J.T.

    2015-01-01

    Abstract Methods from machine learning and data science are becoming increasingly important in the social sciences, providing powerful new ways of identifying statistical relationships in large data sets. However, these relationships do not necessarily offer an understanding of the processes underlying the data. To address this problem, we have developed a method for fitting nonlinear dynamical systems models to data related to social change. Here, we use this method to investigate how countries become trapped at low levels of socioeconomic development. We identify two types of traps. The first is a democracy trap, where countries with low levels of economic growth and/or citizen education fail to develop democracy. The second trap is in terms of cultural values, where countries with low levels of democracy and/or life expectancy fail to develop emancipative values. We show that many key developing countries, including India and Egypt, lie near the border of these development traps, and we investigate the time taken for these nations to transition toward higher democracy and socioeconomic well-being. PMID:26487983

  18. Metacognitive and social cognition approaches to understanding the impact of schizophrenia on social quality of life.

    Science.gov (United States)

    Hasson-Ohayon, Ilanit; Avidan-Msika, Moran; Mashiach-Eizenberg, Michal; Kravetz, Shlomo; Rozencwaig, Silvio; Shalev, Hadar; Lysaker, Paul H

    2015-02-01

    While some studies view metacognition and social cognition as representing the same phenomenon, others suggest that they represent distinctive sets of abilities that are related to different outcomes. The current study used a cross-sectional design that includes samples of persons with schizophrenia (N=39) and healthy individuals (N=60) to further explore the distinction between social cognition and metacognition and their associations with social quality of life. The Face Emotion Identification Task (FEIT), Faux-Pas Task, Indiana Psychiatric Illness Interview (IPII), Metacognition Assessment Scale - Abbreviated (MAS-A), and Social Quality of Life Scale were administrated to all participants. Correlations, t-tests and regressions were conducted. Results showed that persons with schizophrenia performed more poorly on all measures than healthy controls. Social cognition and metacognition measures were related for the combined total sample, but only a few associations were found among both sub-samples. A diagnosis of schizophrenia and metacognitive capacity, but not social cognition, predicted social quality of life. Self-reflectivity had a negative relationship to social quality of life while understanding of others' minds had a positive relation to social quality of life. The current study provides evidence that many with schizophrenia experience deficits in both social cognition and metacognition and that those deficits may be distinct and have different kinds of relationships with social quality of life. Clinical implications include the need to emphasize narrative aspects of psychotherapy in order to promote metacognition. Copyright © 2014 Elsevier B.V. All rights reserved.

  19. A human factors systems approach to understanding team-based primary care: a qualitative analysis

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    Mundt, Marlon P.; Swedlund, Matthew P.

    2016-01-01

    Background. Research shows that high-functioning teams improve patient outcomes in primary care. However, there is no consensus on a conceptual model of team-based primary care that can be used to guide measurement and performance evaluation of teams. Objective. To qualitatively understand whether the Systems Engineering Initiative for Patient Safety (SEIPS) model could serve as a framework for creating and evaluating team-based primary care. Methods. We evaluated qualitative interview data from 19 clinicians and staff members from 6 primary care clinics associated with a large Midwestern university. All health care clinicians and staff in the study clinics completed a survey of their communication connections to team members. Social network analysis identified key informants for interviews by selecting the respondents with the highest frequency of communication ties as reported by their teammates. Semi-structured interviews focused on communication patterns, team climate and teamwork. Results. Themes derived from the interviews lent support to the SEIPS model components, such as the work system (Team, Tools and Technology, Physical Environment, Tasks and Organization), team processes and team outcomes. Conclusions. Our qualitative data support the SEIPS model as a promising conceptual framework for creating and evaluating primary care teams. Future studies of team-based care may benefit from using the SEIPS model to shift clinical practice to high functioning team-based primary care. PMID:27578837

  20. Novel brain imaging approaches to understand acquired and congenital neuro-ophthalmological conditions.

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    Millington, Rebecca S; Ajina, Sara; Bridge, Holly

    2014-02-01

    The arrival of large datasets and the on-going refinement of neuroimaging technology have led to a number of recent advances in our understanding of visual pathway disorders. This work can broadly be classified into two areas, both of which are important when considering the optimal management strategies. The first looks at the delineation of damage, teasing out subtle changes to (specific components of) the visual pathway, which may help evaluate the severity and extent of disease. The second uses neuroimaging to investigate neuroplasticity, via changes in connectivity, cortical thickness, and retinotopic maps within the visual cortex. Here, we give consideration to both acquired and congenital patients with damage to the visual pathway, and how they differ. Congenital disorders of the peripheral visual system can provide insight into the large-scale reorganization of the visual cortex: these are investigated with reference to disorders of the optic chiasm and anophthalmia (absence of the eyes). In acquired conditions, we consider the recent work describing patterns of degeneration, both following single insult and in neurodegenerative conditions. We also discuss the developments in functional neuroimaging, with particular reference to work on hemianopia and the controversial suggestion of cortical reorganization following acquired retinal injury. Techniques for comparing neuro-ophthalmological conditions with healthy visual systems provide sensitive metrics to uncover subtle differences in grey and white matter structure of the brain. It is now possible to compare the massive reorganization present in congenital conditions with the apparent lack of plasticity following acquired damage.

  1. UNsatisfied? The Rocky Path to NATO Membership – Bosnia and Herzegovina: A New Approach in Understanding the Challenges

    Directory of Open Access Journals (Sweden)

    Preljević Hamza

    2017-11-01

    Full Text Available NATO’s enlargement in the Western Balkans (WB has been the focus of a number of debates for almost two decades. Opinions and positions regarding this question range from serious doubts, criticisms and opportunistic press releases to enthusiastic support for membership. This paper assesses Bosnian reforms and policy changes, as well as the country’s efforts to join NATO. Bosnia and Herzegovina (BiH has made significant steps in moving towards NATO’s military and political standards, but not sufficiently. Although BiH is viewed by some observers as a country approaching the point of joining the Membership Action Plan (MAP, this prospect remains uncertain. The findings of this research suggest that BiH is different from other WB countries and that it is not suitable for understanding the NATO integration challenges in the WB. In order to understand Bosnian ‘specifics’, it is necessary not only to view the challenges through the prism of technical and other domestic issues in BiH. A wider approach must be adopted. Through understanding the Bosnian specifics, the dilemmas related to the NATO membership of BiH become more obvious and clear. Bosnian specifics illustrate why BiH is not able to take significant steps towards long-term stabilization and NATO membership.

  2. Tools and perspectives for a unified approach to understanding microbial ecology in the critical zone

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    Gallery, R. E.; Aronson, E. L.; Fairbanks, D.; Murphy, M. A.; Rich, V. I.; Hart, S. C.

    2015-12-01

    Microbial communities that control nutrient transformation and storage in ecosystems are themselves influenced by landscape topography and vegetative cover. Globally, disturbances such as fires and insect outbreaks are increasing in frequency and severity with enormous impacts on global carbon cycling. The resiliency of soil microbial communities to these heterogeneous disturbances determines rates of nutrient transformations as well as ecosystem structure and recovery. Natural and anthropogenic disturbances are a common thread throughout Critical Zone Observatories and ecosystems in general. Using the 2013 Thompson Ridge Fire in the Jemez River Basin CZO as a case study, we examine the effect of a wildfire disturbance regime on successional changes in soil microbiota and ecosystem fluxes across a landscape with high topographic variation. We find that, layered over the topographic controls of hotspots of biogeochemical activity, fire alters organic substrate quality, microbial biomass, community structure, and activity. For example, fire increases soil pH, which is commonly found as an explanatory variable describing bacterial community structure. Soil microbes excrete exoenzymes to decompose polymers and acquire nutrients, and these activities can indicate changing microbial function or soil quality. In these mixed conifer forests, we find shifts from carbon to nitrogen-dominated exoenzyme activities in burned forests with alkaline soils, suggesting shifts of microbial taxa and function that correspond with recovering soil microbial biomass. More generally we ask - what combination of tools and perspectives is needed to fully understand soil microbial ecology and biogeochemistry of the critical zone? Results from an NSF Science Across Virtual Institutes (SAVI) CZO Network Biogeochemistry Workshop highlight the importance of incorporating a standard suite of microbial activity and community assays along with soil biogeochemical and flux measurements to enable

  3. Process Network Approach to Understanding How Forest Ecosystems Adapt to Changes

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    Kim, J.; Yun, J.; Hong, J.; Kwon, H.; Chun, J.

    2011-12-01

    Sustainability challenges are transforming science and its role in society. Complex systems science has emerged as an inevitable field of education and research, which transcends disciplinary boundaries and focuses on understanding of the dynamics of complex social-ecological systems (SES). SES is a combined system of social and ecological components and drivers that interact and give rise to results, which could not be understood on the basis of sociological or ecological considerations alone. However, both systems may be viewed as a network of processes, and such a network hierarchy may serve as a hinge to bridge social and ecological systems. As a first step toward such effort, we attempted to delineate and interpret such process networks in forest ecosystems, which play a critical role in the cycles of carbon and water from local to global scales. These cycles and their variability, in turn, play an important role in the emergent and self-organizing interactions between forest ecosystems and their environment. Ruddell and Kumar (2009) define a process network as a network of feedback loops and the related time scales, which describe the magnitude and direction of the flow of energy, matter, and information between the different variables in a complex system. Observational evidence, based on micrometeorological eddy covariance measurements, suggests that heterogeneity and disturbances in forest ecosystems in monsoon East Asia may facilitate to build resilience for adaptation to change. Yet, the principles that characterize the role of variability in these interactions remain elusive. In this presentation, we report results from the analysis of multivariate ecohydrologic and biogeochemical time series data obtained from temperate forest ecosystems in East Asia based on information flow statistics.

  4. The Hawaiian Islands - Integrated Approach to Understanding the Tsunami Risk in the Pacific (Invited)

    Science.gov (United States)

    Chague-Goff, C.

    2013-12-01

    The Hawaiian Islands, because of their location in the middle of the Pacific Ocean, act as natural ';barometers' for tsunamis generated along the Pacific Ring of Fire, which is the most seismically active area in the world. A multi-proxy study in the remote Pololu valley on the Big Island provided the first evidence for two trans-Pacific events, namely the 1946 and 1957 Aleutian tsunamis. These were identified using radiometric, stratigraphic, microfossil, pollen and geochemical proxies and were corroborated by historical accounts. The islands have been impacted repeatedly by tsunamis in historical times (inc. the recent 2010 Maule and 2011 Tohoku-oki events), and there is strong archaeological evidence for large events affecting humans in prehistory. However, no geological research has yet been carried out, except for some associated with a palaeoecological study on Kauai. Historical evidence shows that tsunamis emanating from the Pacific Ring of Fire have run up to different elevations on different islands within the island chain depending upon their source. Here there is a possible key to understanding some of the key questions about the magnitude and frequency of tsunamis from various parts of the Pacific. Tsunamis from Japan are large on the SW side of the Big Island, those from Alaska seem to have been large in the NE of the island and so on throughout the island chain. A careful site selection from throughout the islands offers a unique opportunity to chart the palaeotsunami record of the Hawaiian Islands while at the same time matching and enhancing the palaeoseismic record of sources in the Pacific Ring of Fire. How big and how often events have occurred in circum-Pacific locations, and how badly they affected other Pacific nations may therefore be addressed by looking in the middle of the Pacific Ocean.

  5. Drug policy constellations: A Habermasian approach for understanding English drug policy.

    Science.gov (United States)

    Stevens, Alex; Zampini, Giulia Federica

    2018-04-24

    It is increasingly accepted that a view of policy as a rational process of fitting evidence-based means to rationally justified ends is inadequate for understanding the actual processes of drug policy making. We aim to provide a better description and explanation of recent English drug policy decisions. We develop the policy constellation concept from the work of Habermas, in dialogue with data from two contemporary debates in English policy; on decriminalisation of drug possession and on recovery in drug treatment. We collect data on these debates through long-term participant observation, stakeholder interviews (n = 15) and documentary analysis. We show the importance of social asymmetries in power in enabling structurally advantaged groups to achieve the institutionalisation of their moral preferences as well as the reproduction of their social and economic power through the deployment of policies that reflect their material interests and normative beliefs. The most influential actors in English drug policy come together in a 'medico-penal constellation', in which the aims and practices of public health and social control overlap. Formal decriminalisation of possession has not occurred, despite the efforts of members of a challenging constellation which supports it. Recovery was put forward as the aim of drug treatment by members of a more powerfully connected constellation. It has been absorbed into the practice of 'recovery-oriented' drug treatment in a way that maintains the power of public health professionals to determine the form of treatment. Actors who share interests and norms come together in policy constellations. Strategic action within and between constellations creates policies that may not take the form that was intended by any individual actor. These policies do not result from purely rational deliberation, but are produced through 'systematically distorted communication'. They enable the most structurally favoured actors to institutionalise

  6. Understanding the Impact of Root Morphology on Overturning Mechanisms: A Modelling Approach

    Science.gov (United States)

    Fourcaud, Thierry; Ji, Jin-Nan; Zhang, Zhi-Qiang; Stokes, Alexia

    2008-01-01

    Background and Aims The Finite Element Method (FEM) has been used in recent years to simulate overturning processes in trees. This study aimed at using FEM to determine the role of individual roots in tree anchorage with regard to different rooting patterns, and to estimate stress distribution in the soil and roots during overturning. Methods The FEM was used to carry out 2-D simulations of tree uprooting in saturated soft clay and loamy sand-like soil. The anchorage model consisted of a root system embedded in a soil block. Two root patterns were used and individual roots removed to determine their contribution to anchorage. Key Results In clay-like soil the size of the root–soil plate formed during overturning was defined by the longest roots. Consequently, all other roots localized within this plate had no influence on anchorage strength. In sand-like soil, removing individual root elements altered anchorage resistance. This result was due to a modification of the shape and size of the root–soil plate, as well as the location of the rotation axis. The tap root and deeper roots had more influence on overturning resistance in sand-like soil compared with clay-like soil. Mechanical stresses were higher in the most superficial roots and also in leeward roots in sand-like soil. The relative difference in stresses between the upper and lower sides of lateral roots was sensitive to root insertion angle. Assuming that root eccentricity is a response to mechanical stresses, these results explain why eccentricity differs depending on root architecture. Conclusions A simple 2-D Finite Element model was developed to better understand the mechanisms involved during tree overturning. It has been shown how root system morphology and soil mechanical properties can modify the shape of the root plate slip surface as well as the position of the rotation axis, which are major components of tree anchorage. PMID:17942593

  7. Public health triangulation: approach and application to synthesizing data to understand national and local HIV epidemics

    Directory of Open Access Journals (Sweden)

    Aberle-Grasse John

    2010-07-01

    Full Text Available Abstract Background Public health triangulation is a process for reviewing, synthesising and interpreting secondary data from multiple sources that bear on the same question to make public health decisions. It can be used to understand the dynamics of HIV transmission and to measure the impact of public health programs. While traditional intervention research and metaanalysis would be ideal sources of information for public health decision making, they are infrequently available, and often decisions can be based only on surveillance and survey data. Methods The process involves examination of a wide variety of data sources and both biological, behavioral and program data and seeks input from stakeholders to formulate meaningful public health questions. Finally and most importantly, it uses the results to inform public health decision-making. There are 12 discrete steps in the triangulation process, which included identification and assessment of key questions, identification of data sources, refining questions, gathering data and reports, assessing the quality of those data and reports, formulating hypotheses to explain trends in the data, corroborating or refining working hypotheses, drawing conclusions, communicating results and recommendations and taking public health action. Results Triangulation can be limited by the quality of the original data, the potentials for ecological fallacy and "data dredging" and reproducibility of results. Conclusions Nonetheless, we believe that public health triangulation allows for the interpretation of data sets that cannot be analyzed using meta-analysis and can be a helpful adjunct to surveillance, to formal public health intervention research and to monitoring and evaluation, which in turn lead to improved national strategic planning and resource allocation.

  8. Proteomics as an approach to the understanding of the molecular physiology of fruit development and ripening.

    Science.gov (United States)

    Palma, José M; Corpas, Francisco J; del Río, Luís A

    2011-08-12

    Fruit ripening is a developmental complex process which occurs in higher plants and involves a number of stages displayed from immature to mature fruits that depend on the plant species and the environmental conditions. Nowadays, the importance of fruit ripening comes mainly from the link between this physiological process in plants and the economic repercussions as a result of one of the human activities, the agricultural industry. In most cases, fruit ripening is accompanied by colour changes due to different pigment content and increases in sugar levels, among others. Major physiological modifications that affect colour, texture, flavour, and aroma are under the control of both external (light and temperature) and internal (developmental gene regulation and hormonal control) factors. Due to the huge amount of metabolic changes that take place during ripening in fruits from higher plants, the accomplishment of new throughput methods which can provide a global evaluation of this process would be desirable. Differential proteomics of immature and mature fruits would be a useful tool to gain information on the molecular changes which occur during ripening, but also the investigation of fruits at different ripening stages will provide a dynamic picture of the whole transformation of fruits. This subject is furthermore of great interest as many fruits are essential for human nutrition. Thus far different maturation profiles have been reported specific for each crop species. In this work, a thorough review of the proteomic database from fruit development and maturation of important crop species will be updated to understand the molecular physiology of fruits at ripening stages. Copyright © 2011 Elsevier B.V. All rights reserved.

  9. A life course approach to understanding social drivers of rangeland conversion

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    Kristin F. Hurst

    2017-03-01

    Full Text Available Grassland to woodland conversion, also known as woody plant encroachment (WPE, is a global-scale phenomena caused in large part by changes in social processes that affect rural land use patterns. Woody plant encroachment has raised serious concerns for species conservation, provision of ecosystem services, and viability of rural livelihoods and cultures. We examined the social drivers of WPE using a case study of rangelands in a semi-arid watershed. We employed the life course framework to understand how ranchers have made land ranch management decisions in the context of time, culture, and social change. We interviewed landowners whose families have been on the land for at least two generations to examine (1 the social context influencing a landowner's decision to increase or decrease their involvement in ranching over their life span, and (2 the historical events that facilitated constrained involvement. We relate these changes in involvement to the expansion of woody plants. Three major turning points were related to changes in ranching involvement: graduating high school, retirement, and infirmity of a parent. We found that changes in ranching involvement were influenced by large-scale shifts in culture, market regulations, and land values throughout the 20th century. These shifts led to three behavioral changes on the land that facilitated WPE: (1 changes in livestock following the collapse of the sheep and goat market, (2 increased popularity of hunting, and (3 decreased labor availability on the ranch. These observations illustrate the complex social and ecological forces at work throughout the 20th century that have led to land transformation in central Texas.

  10. Gun possession among American youth: a discovery-based approach to understand gun violence.

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    Kelly V Ruggles

    Full Text Available OBJECTIVE: To apply discovery-based computational methods to nationally representative data from the Centers for Disease Control and Preventions' Youth Risk Behavior Surveillance System to better understand and visualize the behavioral factors associated with gun possession among adolescent youth. RESULTS: Our study uncovered the multidimensional nature of gun possession across nearly five million unique data points over a ten year period (2001-2011. Specifically, we automated odds ratio calculations for 55 risk behaviors to assemble a comprehensive table of associations for every behavior combination. Downstream analyses included the hierarchical clustering of risk behaviors based on their association "fingerprint" to 1 visualize and assess which behaviors frequently co-occur and 2 evaluate which risk behaviors are consistently found to be associated with gun possession. From these analyses, we identified more than 40 behavioral factors, including heroin use, using snuff on school property, having been injured in a fight, and having been a victim of sexual violence, that have and continue to be strongly associated with gun possession. Additionally, we identified six behavioral clusters based on association similarities: 1 physical activity and nutrition; 2 disordered eating, suicide and sexual violence; 3 weapon carrying and physical safety; 4 alcohol, marijuana and cigarette use; 5 drug use on school property and 6 overall drug use. CONCLUSIONS: Use of computational methodologies identified multiple risk behaviors, beyond more commonly discussed indicators of poor mental health, that are associated with gun possession among youth. Implications for prevention efforts and future interdisciplinary work applying computational methods to behavioral science data are described.

  11. Gun Possession among American Youth: A Discovery-Based Approach to Understand Gun Violence

    Science.gov (United States)

    Ruggles, Kelly V.; Rajan, Sonali

    2014-01-01

    Objective To apply discovery-based computational methods to nationally representative data from the Centers for Disease Control and Preventions’ Youth Risk Behavior Surveillance System to better understand and visualize the behavioral factors associated with gun possession among adolescent youth. Results Our study uncovered the multidimensional nature of gun possession across nearly five million unique data points over a ten year period (2001–2011). Specifically, we automated odds ratio calculations for 55 risk behaviors to assemble a comprehensive table of associations for every behavior combination. Downstream analyses included the hierarchical clustering of risk behaviors based on their association “fingerprint” to 1) visualize and assess which behaviors frequently co-occur and 2) evaluate which risk behaviors are consistently found to be associated with gun possession. From these analyses, we identified more than 40 behavioral factors, including heroin use, using snuff on school property, having been injured in a fight, and having been a victim of sexual violence, that have and continue to be strongly associated with gun possession. Additionally, we identified six behavioral clusters based on association similarities: 1) physical activity and nutrition; 2) disordered eating, suicide and sexual violence; 3) weapon carrying and physical safety; 4) alcohol, marijuana and cigarette use; 5) drug use on school property and 6) overall drug use. Conclusions Use of computational methodologies identified multiple risk behaviors, beyond more commonly discussed indicators of poor mental health, that are associated with gun possession among youth. Implications for prevention efforts and future interdisciplinary work applying computational methods to behavioral science data are described. PMID:25372864

  12. Machine Learning Approach for Prediction and Understanding of Glass-Forming Ability.

    Science.gov (United States)

    Sun, Y T; Bai, H Y; Li, M Z; Wang, W H

    2017-07-20

    The prediction of the glass-forming ability (GFA) by varying the composition of alloys is a challenging problem in glass physics, as well as a problem for industry, with enormous financial ramifications. Although different empirical guides for the prediction of GFA were established over decades, a comprehensive model or approach that is able to deal with as many variables as possible simultaneously for efficiently predicting good glass formers is still highly desirable. Here, by applying the support vector classification method, we develop models for predicting the GFA of binary metallic alloys from random compositions. The effect of different input descriptors on GFA were evaluated, and the best prediction model was selected, which shows that the information related to liquidus temperatures plays a key role in the GFA of alloys. On the basis of this model, good glass formers can be predicted with high efficiency. The prediction efficiency can be further enhanced by improving larger database and refined input descriptor selection. Our findings suggest that machine learning is very powerful and efficient and has great potential for discovering new metallic glasses with good GFA.

  13. A statistical approach to understanding reproductive isolation in two sympatric species of tree crickets.

    Science.gov (United States)

    Bhattacharya, Monisha; Isvaran, Kavita; Balakrishnan, Rohini

    2017-04-01

    In acoustically communicating animals, reproductive isolation between sympatric species is usually maintained through species-specific calls. This requires that the receiver be tuned to the conspecific signal. Mapping the response space of the receiver onto the signal space of the conspecific investigates this tuning. A combinatorial approach to investigating the response space is more informative as the influence on the receiver of the interactions between the features is also elucidated. However, most studies have examined individual preference functions rather than the multivariate response space. We studied the maintenance of reproductive isolation between two sympatric tree cricket species ( Oecanthus henryi and Oecanthus indicus ) through the temporal features of the calls. Individual response functions were determined experimentally for O. henryi , the results from which were combined in a statistical framework to generate a multivariate quantitative receiver response space. The predicted response was higher for the signals of the conspecific than for signals of the sympatric heterospecific, indicating maintenance of reproductive isolation through songs. The model allows prediction of response to untested combinations of temporal features as well as delineation of the evolutionary constraints on the signal space. The model can also be used to predict the response of O. henryi to other heterospecific signals, making it a useful tool for the study of the evolution and maintenance of reproductive isolation via long-range acoustic signals. © 2017. Published by The Company of Biologists Ltd.

  14. Molecular Approaches to Understanding Transmission and Source Attribution in Nontyphoidal Salmonella and Their Application in Africa.

    Science.gov (United States)

    Mather, Alison E; Vaughan, Timothy G; French, Nigel P

    2015-11-01

    Nontyphoidal Salmonella (NTS) is a frequent cause of diarrhea around the world, yet in many African countries it is more commonly associated with invasive bacterial disease. Various source attribution models have been developed that utilize microbial subtyping data to assign cases of human NTS infection to different animal populations and foods of animal origin. Advances in molecular microbial subtyping approaches, in particular whole-genome sequencing, provide higher resolution data with which to investigate these sources. In this review, we provide updates on the source attribution models developed for Salmonella, and examine the application of whole-genome sequencing data combined with evolutionary modeling to investigate the putative sources and transmission pathways of NTS, with a focus on the epidemiology of NTS in Africa. This is essential information to decide where, what, and how control strategies might be applied most effectively. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  15. Inherit the policy: A sociocultural approach to understanding evolutionary biology policy in South Carolina

    Science.gov (United States)

    Moore, Gregory D.

    South Carolina biology Indicator 5.6 calls for students to "Summarize ways that scientists use data from a variety of sources to investigate and critically analyze aspects of evolutionary theory" (South Carolina Department of Education, 2006). Levinson and Sutton (2001) offered a sociocultural approach to policy that considers cultural and historical influences at all levels of the policy process. Lipsky (1980/2010) and others have identified teachers as de facto policy makers, exercising broad discretion in the execution of their work. This study looks to Ajzen's Theory of Planned Behavior as an initial framework to inform how evolutionary biology policy in South Carolina is conceptualized and understood at different levels of the policy process. The results of this study indicate that actors in the state's evolutionary biology policy process draw upon a myriad of Discourses (Gee, 1999/2005). These Discourses shape cultural dynamics and the agency of the policy actors as they navigate conflicting messages between testing mandates and evolutionary biology policy. There indeed exist gaps between how evolutionary biology policy in South Carolina is conceptualized and understood at the different levels of the policy process. Evidence from this study suggests that appropriation-level policy actors must be brought into the Discourse related to the critical analysis of evolutionary biology and academic freedom legislation must be enacted if South Carolina biology Indicator 5.6 is to realize practical significance in educational policy.

  16. Finding Home: A Qualitative Approach to Understanding Adolescent Mothers' Housing Instability.

    Science.gov (United States)

    Elliott, Margaret C; Shuey, Elizabeth A; Zaika, Natalya; Mims, Lauren; Leventhal, Tama

    2017-09-01

    Many low-income Latina adolescent mothers face instability in their housing circumstances, which has implications for their long-term prospects and that of their children. This study used longitudinal, ethnographic data from Welfare, Children, and Families: A Three-City Study to explore experiences of low-income, Latina adolescent mothers (N = 15) with unstable housing who primarily rely on their families or the families of their significant others for housing support. Results of analysis employing grounded theory and narrative approaches suggested two types of instability: "Horizontal moves" between family homes and "vertical moves" between family homes and independent living. Although family support often was fundamental in allowing for participants' pursuit of independent housing (i.e., vertical moves), it also was associated with greater residential mobility (i.e., horizontal moves), most often in the context of intrafamilial conflict and family instability. These results are discussed with respect to inconsistencies in policies to address this vulnerable population. © Society for Community Research and Action 2016.

  17. Understanding enhanced tourist experiences through technology: a brief approach to the Vilnius case

    Directory of Open Access Journals (Sweden)

    Ilona Beliatskaya

    2017-11-01

    Full Text Available The present research investigates the notion of enhanced tourist experiences through technology shedding light on co-creation practices and empowerment of customers. Neuhofer and Buhalis (2013 introduced a novel concept of technology-enhanced tourist experiences by generating a joint comprehension of new era of experiences which conjoin the elements of experiences, co-creation and technology. Being one of rather promoting cities in online environment Vilnius represents an interesting case of successive adoption of smart technologies in order to enhance tourist experiences and facilitate customer empowerment in Vilnius tourism domain. This study aims to determine technology-enhanced tourist experiences in order to measure factors of customer empowerment on the example of international incoming tourists to Vilnius (Lithuania. The mix-methods approach (qualitative online content and functionality analysis and quantitative survey was justified as being the most appropriate for the purpose of this research with intention to find a basis for applying of technology-enhanced tourist experiences in Vilnius tourism marketplace. The paper concludes with the definition of current level of ICTs application to enhance tourist experience co-creation and a discussion of practical implications of technology-enhanced tourist experiences development.

  18. A Capability Approach to Understanding Sport for Social Inclusion: Agency, Structure and Organisations

    Directory of Open Access Journals (Sweden)

    Naofumi Suzuki

    2017-06-01

    Full Text Available Despite the global diffusion of the term social inclusion, as well as the use of sport to promote it, questions have been raised regarding the extent to which sport is able to contribute to transforming the exclusive nature of the social structure. The lack of analytical clarity of the concept has not helped to address these questions. This article proposes a conceptual framework based on Amartya Sen’s capability approach, considering social exclusion as the denial of social relations that leads to serious deprivation of important capabilities. A person’s capabilities could potentially be improved through micro-, meso-, and macro-level social processes. At the micro level, sport-based social inclusion programmes could offer such social relations to varying degrees, though sport’s values are only relative to other leisure activities. The scale of impact depends primarily on the meso-level processes, in which the size and quality of each programme can be improved through organisational learning, and secondarily on the macro-level processes whereby the organisational population is institutionalised. It is argued that more research needs to be done on the meso and macro levels, as they are concerned with the ultimate potential of sport to facilitate structural transformation towards more socially inclusive society.

  19. Multidisciplinary approaches and assessment techniques to better understand and enhance zoo nonhuman animal welfare.

    Science.gov (United States)

    Siegford, Janice M

    2013-01-01

    Nonhuman animal welfare is a complex concept that encompasses an animal's biological functioning, emotional states, and opportunities to experience a natural life, including the performance of natural behaviors. Further, animal welfare can be viewed as quality of life from the perspective of the animal and thus must consider the animal's subjective experiences. Therefore, assessing and enhancing animal welfare should include multidisciplinary, scientific ventures that strive to create a complete picture of how animals' bodies and minds respond to both aversive and pleasant situations. Practical assessment of animal welfare should include outcome-based measures from the animal that provide information about the individual's welfare as well as resource-based measures that can help identify causes of or risk factors for poor welfare. Increasingly, scientists are examining the emotional states of animals as well as the impact of pain, pleasure, and consciousness on animal welfare. This article discusses approaches such as preference testing, instrumental learning, examination of space and resource use, and qualitative assessments of animal welfare that might be useful and practical for assessing and enhancing welfare in zoo settings.

  20. Different approaches, one target: understanding cellular mechanisms of Parkinson's and Alzheimer's diseases.

    Science.gov (United States)

    Torrão, Andréa S; Café-Mendes, Cecilia C; Real, Caroline C; Hernandes, Marina S; Ferreira, Ana F B; Santos, Taisa O; Chaves-Kirsten, Gabriela P; Mazucanti, Caio H Y; Ferro, Emer S; Scavone, Cristoforo; Britto, Luiz R G

    2012-10-01

    Neurodegenerative disorders are undoubtedly an increasing problem in the health sciences, given the increase of life expectancy and occasional vicious life style. Despite the fact that the mechanisms of such diseases are far from being completely understood, a large number of studies that derive from both the basic science and clinical approaches have contributed substantial data in that direction. In this review, it is discussed several frontiers of basic research on Parkinson's and Alzheimer's diseases, in which research groups from three departments of the Institute of Biomedical Sciences of the University of São Paulo have been involved in a multidisciplinary effort. The main focus of the review involves the animal models that have been developed to study cellular and molecular aspects of those neurodegenerative diseases, including oxidative stress, insulin signaling and proteomic analyses, among others. We anticipate that this review will help the group determine future directions of joint research in the field and, more importantly, set the level of cooperation we plan to develop in collaboration with colleagues of the Nucleus for Applied Neuroscience Research that are mostly involved with clinical research in the same field.

  1. Understanding the utility of emotional approach coping: evidence from a laboratory stressor and daily life.

    Science.gov (United States)

    Juth, Vanessa; Dickerson, Sally S; Zoccola, Peggy M; Lam, Suman

    2015-01-01

    Dispositional emotional approach coping (EAC) marks an adaptive tendency to process and express emotions. EAC's association with cognitions, affect, and intra- and interindividual characteristics that may account for its utility was examined in response to an acute stressor and in daily life. This study included a laboratory stress task and ecological momentary assessment. Healthy undergraduate students (n = 124; mean age: 20; women: 56%) completed a laboratory component (baseline survey, speech stress task, pre- and posttask measures) and five subsequent days of surveys via palm pilot (six surveys/day). Controlling for sex, neuroticism, and social support, greater EAC was associated with more positive cognitive appraisals, personal resources, and positive affect and less-negative affect during the lab stressor, and with more perceived control and positive affect in daily life. Significant EAC × sex interactions were found for poststressor affect: men with high EAC reported more positive affect and women with high EAC reported less negative affect. Findings provide support that EAC's utility may be independent of intra- and interindividual characteristics, and that men and women may benefit from EAC in different ways in regards to affect. The proclivity to use EAC may come with a resiliency that protects against stress and promotes general well-being.

  2. A Fuzzy Color-Based Approach for Understanding Animated Movies Content in the Indexing Task

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    Vasile Buzuloiu

    2008-04-01

    Full Text Available This paper proposes a method for detecting and analyzing the color techniques used in the animated movies. Each animated movie uses a specific color palette which makes its color distribution one major feature in analyzing the movie content. The color palette is specially tuned by the author in order to convey certain feelings or to express artistic concepts. Deriving semantic or symbolic information from the color concepts or the visual impression induced by the movie should be an ideal way of accessing its content in a content-based retrieval system. The proposed approach is carried out in two steps. The first processing step is the low-level analysis. The movie color content gets represented with several global statistical parameters computed from the movie global weighted color histogram. The second step is the symbolic representation of the movie content. The numerical parameters obtained from the first step are converted into meaningful linguistic concepts through a fuzzy system. They concern mainly the predominant hues of the movie, some of Itten’s color contrasts and harmony schemes, color relationships and color richness. We use the proposed linguistic concepts to link to given animated movies according to their color techniques. In order to make the retrieval task easier, we also propose to represent color properties in a graphical manner which is similar to the color gamut representation. Several tests have been conducted on an animated movie database.

  3. A Micro and Mesocosm Approach to Understanding the Response of Branched GDGTs to Environmental Perturbation

    Science.gov (United States)

    Martínez-Sosa, P.; Tierney, J. E.; Castañeda, I. S.

    2017-12-01

    Branched glycerol dialkyl glycerol tetraethers (brGDGTs) are membrane lipids with 15 known structures. Thought to be synthesized by bacteria, they are found in peatlands, soils, near-shore marine sediments and lakes. Previous studies have reported a correlation between the number and position of methyl groups and cyclopentane moieties in these lipids with environmental factors such as pH and temperature, leading to the creation of the methylation and cyclisation indices (MBT and CBT respectively). Although an empirical relationship between these structural modifications and environmental conditions has been described, the source organism for these molecules remains unknown. Lacking pure cultures of brGDGT producing bacteria, a different approach is necessary to study their response to environmental perturbations under controlled conditions. To this end, we studied the production of brGDGTs in water from two fishing lakes in Arizona using a series of microcosms, comprised by 1L flasks filled with environmental water; and mesocosm experiments, where two 20L tanks were filled with either lake water or lake water and synthetic sediments. This experimental design allowed us to modify environmental factors while preserving the natural conditions of the sample. Our experiments point to a production of brGDGTs on the suspended particulate matter in the water column, which appears to contribute to some extent to the presence of this molecules on lake sediments. Furthermore, we observed a shift in the ratio between 5' and 6' isomers related to both the presence of a carbon source and temperature. Limited oxygen availability appears to correlate with higher brGDGT concentration. Notably, we find that methylation decreases with increasing temperature in our experiments at a rate that is roughly in agreement with empirical observations. To our knowledge, these experiments provide the first evidence of growth and alteration of brGDGTs under laboratory conditions, which could be

  4. Toward an understanding of the molecular mechanisms of barnacle larval settlement: A comparative transcriptomic approach

    KAUST Repository

    Chen, Zhang-Fan

    2011-07-29

    Background: The barnacle Balanus amphitrite is a globally distributed biofouler and a model species in intertidal ecology and larval settlement studies. However, a lack of genomic information has hindered the comprehensive elucidation of the molecular mechanisms coordinating its larval settlement. The pyrosequencing-based transcriptomic approach is thought to be useful to identify key molecular changes during larval settlement. Methodology and Principal Findings: Using 454 pyrosequencing, we collected totally 630,845 reads including 215,308 from the larval stages and 415,537 from the adults; 23,451 contigs were generated while 77,785 remained as singletons. We annotated 31,720 of the 92,322 predicted open reading frames, which matched hits in the NCBI NR database, and identified 7,954 putative genes that were differentially expressed between the larval and adult stages. Of these, several genes were further characterized with quantitative real-time PCR and in situ hybridization, revealing some key findings: 1) vitellogenin was uniquely expressed in late nauplius stage, suggesting it may be an energy source for the subsequent non-feeding cyprid stage; 2) the locations of mannose receptors suggested they may be involved in the sensory system of cyprids; 3) 20 kDa-cement protein homologues were expressed in the cyprid cement gland and probably function during attachment; and 4) receptor tyrosine kinases were expressed higher in cyprid stage and may be involved in signal perception during larval settlement. Conclusions: Our results provide not only the basis of several new hypotheses about gene functions during larval settlement, but also the availability of this large transcriptome dataset in B. amphitrite for further exploration of larval settlement and developmental pathways in this important marine species. © 2011 Chen et al.

  5. A Metal Stable Isotope Approach to Understanding Uranium Mobility Across Roll Front Redox Boundaries

    Science.gov (United States)

    Brown, S. T.; Basu, A.; Christensen, J. N.; DePaolo, D. J.; Heikoop, J. M.; Reimus, P. W.; Maher, K.; Weaver, K. L.

    2015-12-01

    Sedimentary roll-front uranium (U) ore deposits are the principal source of U for nuclear fuel in the USA and an important part of the current all-of-the-above energy strategy. Mining of roll-front U ore in the USA is primarily by in situ alkaline oxidative dissolution of U minerals. There are significant environmental benefits to in situ mining including no mine tailings or radioactive dust, however, the long-term immobilization of U in the aquifer after the completion of mining remains uncertain. We have utilized the metal stable isotopes U, Se and Mo in groundwater from roll-front mines in Texas and Wyoming to quantify the aquifer redox conditions and predict the onset of U reduction after post mining aquifer restoration. Supporting information from the geochemistry of groundwater and aquifer sediments are used to understand the transport of U prior to and after in situ mining. Groundwater was collected across 4 mining units at the Rosita mine in the Texas coastal plain and 2 mining units at the Smith Ranch mine in the Powder River Basin, Wyoming. In general, the sampled waters are moderately reducing and ore zone wells contain the highest aqueous U concentrations. The lowest U concentrations occur in monitoring wells downgradient of the ore zone. 238U/235U is lowest in downgradient wells and is correlated with aqueous U concentrations. Rayleigh distillation models of the 238U/235U are consistent with U isotope fractionation factors of 1.0004-1.001, similar to lab-based studies. Based on these results we conclude that redox reactions continue to affect U distribution in the ore zone and downgradient regions. We also measured aqueous selenium isotope (δ82Se) and molybdenum isotope (δ98Mo) compositions in the Rosita groundwater. Se(VI) primarily occurs in the upgradient wells and is absent in most ore zone and downgradient wells. Rayleigh distillation models suggest reduction of Se(VI) along the groundwater flow path and when superimposed on the U isotope data

  6. An Immunogenomics Approach to Understanding Periparturient Immunosuppression and Mastitis Susceptibility in Dairy Cows*

    Directory of Open Access Journals (Sweden)

    Sipkovsky SS

    2003-03-01

    Full Text Available Studies comparing in vivo and in vitro functional capacities of leukocytes from non-parturient and periparturient dairy cows have provided substantial evidence that systemic and local mammary immune defenses are deficient around parturition. This evidence has lead to the reasonable hypothesis that immune deficiency underlies the heightened mastitis susceptibility of periparturient cows. Nutrition and vaccine studies substantiate this hypothesis, showing that dietary antioxidant supplementation and rigorous immunization regimes can bolster innate and humoral immunity to the point that mastitis severity and time for return to normal milk production are reduced. However, completely effective resolution of this significant production disease has not been achieved because so little is understood about its complex etiology. In particular, we possess almost no knowledge of how or why immune cells responding to parturient physiology end up with deficient functional capacities. Fluctuations in reproductive steroid hormones and chronic shifts in neuroendocrine hormones with roles in nutrient partitioning and appetite control may affect the expression of critical leukocyte genes in periparturient dairy cows. A thorough understanding of leukocyte biology during periparturition would seem a critical goal for future development of effective mastitis prevention strategies. Recently, our group has begun to use cDNA microarray technology to explore bovine leukocyte RNA for global gene expression changes occurring around parturition. We are working within the context of a hypothesis that the physiology of parturition negatively affects expression of critical genes in blood leukocytes. In the current study we initiated hypothesis testing using leukocyte RNA from a high producing Holstein cow collected at 14 days prepartum and 6 hours postpartum to interrogate a cDNA microarray spotted with >700 cDNAs representing unique bovine leukocyte genes. This analysis

  7. Understanding DRM acquisition of plates and spheres: a first comparative experimental approach

    Science.gov (United States)

    Bilardello, Dario

    2013-10-01

    Since King presented the `plates and spheres' model in an attempt to investigate the origin of the inclination error in sediments, no one to date has conducted specific experiments designed to separate the individual contribution of platy and spherical particles to depositional remanent magnetizations (DRMs). It is commonly accepted that it is the flattening of plates, rather than the rolling of spheres that is the main source of inclination error in sediments. Recently, however, Bilardello et al. have shown that spheres alone may lead to significant amounts of shallowing. A comparison of experiments run in parallel using synthetic platy and spherical particles is presented. Experiments of the duration of 24 hr were run in 100 μT field intensity (μ0H) and varying field inclinations (IF) from vertical to horizontal. A systematic dependence of the magnetization on field inclination is apparent. Results indicate that magnetic moment measurements are more repeatable for spherical particles than for plates, yielding smaller uncertainties. Inclination measurements, however, are more repeatable for platy particles, with a more linear relationship of inclination error to applied field inclination. Moreover, plates yield smaller inclination error than spheres. A clear field inclination dependency of the inclination error also exists, with the error decreasing through field inclinations of 30°, 60° and 90°. A continuous acquisition experiment involving plates was also run up to 10 d of deposition in μ0H = 100 μT and IF = 60°. The acquisition curves for moment, inclination and thickness of depositing sediment are compared to the mean curves measured for spheres by Bilardello et al. under the same field conditions. No unequivocal evidence of compaction of the platy particles is observed, while the inclination error is acquired virtually instantaneously for all particles. These preliminary results contradict the widespread understanding that inclination shallowing is

  8. Analytical Approaches to Understanding the Role of Non-carbohydrate Components in Wood Biorefinery

    Science.gov (United States)

    Leskinen, Timo Ensio

    . Additional studies revealed that an insoluble, likely crosslinked, lignin fraction induced enzyme inhibition, while soluble lower molecular weight fractions were slightly beneficial for the enzymatic hydrolysis of cellulose. The third section of the work addresses the influence of hydrophobic wood extractives and representative model compounds on the cellulolytic hydrolysis of cellulosic substrates. Deposition of specific fractions of isolated wood extractives on cellulose was found either to enhance or inhibit the action of cellulase enzymes, depending on the chemical nature of the fraction. Using model compounds this effect was found to be correlated with the compounds chemical structure, and underlying mechanisms could be rationalized by Hansen solubility parameter considerations. The amphiphilic and hydrophobic nature of the model extractives was found to influence the deposition of extractives on the cellulose surfaces, and the adsorption of cellulolytic enzymes, as measured with Quartz Crystal Microgravimetry. Beneficial effects of the extractives were likely related to reduction in the irreversible binding of the enzymes on the cellulose substrate. The fourth section of the work deals with the recovery of lignin using extraction methods based on aqueous alkali or aqueous ethanol. The objective of this study was to understand how the yield, MW and structure of lignin recovered from the process residue was impacted by the different isolation methods. Mild extraction conditions allowed for recovery of approximately 40 wt.% of the lignin present in the process residues. Base or acid catalyzed hydrolysis of the lignin could increase the recovery lignin yield to about 76 wt.%. The recovered lignins were characterized in terms of their functional groups, molecular weights and thermal properties. The lignins from mild alkali and ethanol extractions showed similarities in their chemical profiles while, as expected, the hydrolyzed lignins were different and depended on the

  9. Integrated approach to the understanding of the degradation of an urban river: local perceptions, environmental parameters and geoprocessing.

    Science.gov (United States)

    Collier, Carolina A; Almeida Neto, Miguel S de; Aretakis, Gabriela M A; Santos, Rangel E; de Oliveira, Tiago H; Mourão, José S; Severi, William; El-Deir, Ana C A

    2015-09-15

    The use of interdisciplinary approaches such as the proposed report provides a broad understanding of the relationship between people and the environment, revealing reliable aspects not previously considered in the study of this relationship. This study compiled evidence on the environmental degradation of an urbanized river over the past few decades, providing a diagnosis of the consequences of this process for the river, its ichthyofauna, and the local human population. The study was focused on the Beira Rio community on the Capibaribe River in the municipality of São Lourenço da Mata, Pernambuco, Brazil. Data were collected using geoprocessing and ethnobiological approaches, as well as environmental parameters. This research was conducted with the most experienced long-term residents in the local community, through interviews and participatory methodologies to recovering information about the river environment, its ichthyofauna and its environmental services for the last decades. According to the GIS analysis, the study area was subject to an accelerated process of urbanization, with the total urban area increasing from 73 565, 98 m(2) in 1974 to 383 363, 6 m(2) in 2005. The informants perceived the urban growth, especially in the late twentieth century, being this period recognized as the phase of greatest negative changes in the river environment. The perceived decline of fish stocks was indicated by the community as one of the effects of river degradation. According to the interviews, the deterioration of the river affected the ecosystem services and the relationship of the adjacent human community with this ecosystem. The environmental data indicated that the river is suffering eutrophization and has fecal coliform concentrations 160 times higher than the maximum level permitted by Brazilian legislation. The interdisciplinary approach used in this research allowed the understanding of the degradation process of an urban river and some negative effects

  10. Guiding students to develop an understanding of scientific inquiry: a science skills approach to instruction and assessment.

    Science.gov (United States)

    Stone, Elisa M

    2014-01-01

    New approaches for teaching and assessing scientific inquiry and practices are essential for guiding students to make the informed decisions required of an increasingly complex and global society. The Science Skills approach described here guides students to develop an understanding of the experimental skills required to perform a scientific investigation. An individual teacher's investigation of the strategies and tools she designed to promote scientific inquiry in her classroom is outlined. This teacher-driven action research in the high school biology classroom presents a simple study design that allowed for reciprocal testing of two simultaneous treatments, one that aimed to guide students to use vocabulary to identify and describe different scientific practices they were using in their investigations-for example, hypothesizing, data analysis, or use of controls-and another that focused on scientific collaboration. A knowledge integration (KI) rubric was designed to measure how students integrated their ideas about the skills and practices necessary for scientific inquiry. KI scores revealed that student understanding of scientific inquiry increased significantly after receiving instruction and using assessment tools aimed at promoting development of specific inquiry skills. General strategies for doing classroom-based action research in a straightforward and practical way are discussed, as are implications for teaching and evaluating introductory life sciences courses at the undergraduate level.

  11. Understanding response patterns in dyadic conflict: An interactive approach combining self-construal and opponent's dominance-submissiveness.

    Science.gov (United States)

    Au, Al K C; Lam, Shui-Fong

    2017-04-01

    Previous works on the effect of self-construal in interpersonal behaviours tend to adopt a main effect approach. The present research proposes an interactive approach in understanding two response patterns in dyadic conflict by combining self-construal and the stance of the opponent. Independent self-construal was hypothesised to be associated with a self-centred pattern of conflict response, which is characterised by taking contending responses regardless of whether the stance of the opponent is dominant or submissive. Relational self-construal was hypothesised to be associated with a tuning-in pattern of conflict response, which is characterised by showing contending responses when the opponent is submissive but yielding responses when the opponent is dominant. With trait self-construal measured and opponent's stance manipulated, Study 1 provided initial support for the hypotheses. Study 2 showed a three-way interaction effect between trait self-construal, manipulated self-construal and the opponent's stance on actual conflict responses during discussion of a scenario. The effect of self-construal manipulation was only observed among people who were low in trait independent self-construal and average in trait relational self-construal. The results pinpoint the importance of considering personal and opponent factors simultaneously in understanding the dynamics of dyadic conflict processes. © 2015 International Union of Psychological Science.

  12. A Science-Based Approach to Understanding Waste Form Durability in Open and Closed Nuclear Fuel Cycles

    International Nuclear Information System (INIS)

    Peters, M.T.; Ewing, R.C.

    2007-01-01

    There are two compelling reasons for understanding source term and near-field processes in a radioactive waste geologic repository. First, almost all of the radioactivity is initially in the waste form, mainly in the spent nuclear fuel (SNF) or nuclear waste glass. Second, over long periods, after the engineered barriers are degraded, the waste form is a primary control on the release of radioactivity. Thus, it is essential to know the physical and chemical state of the waste form after hundreds of thousands of years. The United States Department of Energy's Yucca Mountain Repository Program has initiated a long-term program to develop a basic understanding of the fundamental mechanisms of radionuclide release and a quantification of the release as repository conditions evolve over time. Specifically, the research program addresses four critical areas: a) SNF dissolution mechanisms and rates; b) formation and properties of U 6+ - secondary phases; c) waste form-waste package interactions in the near-field; and d) integration of in-package chemical and physical processes. The ultimate goal is to integrate the scientific results into a larger scale model of source term and near-field processes. This integrated model will be used to provide a basis for understanding the behavior of the source term over long time periods (greater than 10 5 years). Such a fundamental and integrated experimental and modeling approach to source term processes can also be readily applied to development of advanced waste forms as part of a closed nuclear fuel cycle. Specifically, a fundamental understanding of candidate waste form materials stability in high temperature/high radiation environments and near-field geochemical/hydrologic processes could enable development of advanced waste forms 'tailored' to specific geologic settings. (authors)

  13. A Science-Based Approach to Understanding Waste Form Durability in Open and Closed Nuclear Fuel Cycles

    International Nuclear Information System (INIS)

    M.T. Peters; R.C. Ewing

    2006-01-01

    There are two compelling reasons for understanding source term and near-field processes in a radioactive waste geologic repository. First, almost all of the radioactivity is initially in the waste form, mainly in the spent nuclear fuel (SNF) or nuclear waste glass. Second, over long periods, after the engineered barriers are degraded, the waste form is a primary control on the release of radioactivity. Thus, it is essential to know the physical and chemical state of the waste form after hundreds of thousands of years. The United States Department of Energy's Yucca Mountain Repository Program has initiated a long-term program to develop a basic understanding of the fundamental mechanisms of radionuclide release and a quantification of the release as repository conditions evolve over time. Specifically, the research program addresses four critical areas: (a) SNF dissolution mechanisms and rates; (b) formation and properties of U 6+ -secondary phases; (c) waste form-waste package interactions in the near-field; and (d) integration of in-package chemical and physical processes. The ultimate goal is to integrate the scientific results into a larger scale model of source term and near-field processes. This integrated model will be used to provide a basis for understanding the behavior of the source term over long time periods (greater than 10 5 years). Such a fundamental and integrated experimental and modeling approach to source term processes can also be readily applied to development of advanced waste forms as part of a closed nuclear fuel cycle. Specifically, a fundamental understanding of candidate waste form materials stability in high temperature/high radiation environments and near-field geochemical/hydrologic processes could enable development of advanced waste forms ''tailored'' to specific geologic settings

  14. Understanding homelessness

    OpenAIRE

    Somerville, Peter

    2013-01-01

    This paper reviews the literature on understanding homelessness. It criticizes approaches that ignore, distort or diminish the humanity of homeless people, or else, add little to our understanding of that humanity. In particular, it rejects what it calls “epidemiological” approaches, which deny the possibility of agency for homeless people, insofar as those approaches view the situation of those people largely as a “social fact”, to be explained in terms of causal variables or “risk factors” ...

  15. Understanding Forest Health with Remote Sensing-Part II—A Review of Approaches and Data Models

    Directory of Open Access Journals (Sweden)

    Angela Lausch

    2017-02-01

    Full Text Available Stress in forest ecosystems (FES occurs as a result of land-use intensification, disturbances, resource limitations or unsustainable management, causing changes in forest health (FH at various scales from the local to the global scale. Reactions to such stress depend on the phylogeny of forest species or communities and the characteristics of their impacting drivers and processes. There are many approaches to monitor indicators of FH using in-situ forest inventory and experimental studies, but they are generally limited to sample points or small areas, as well as being time- and labour-intensive. Long-term monitoring based on forest inventories provides valuable information about changes and trends of FH. However, abrupt short-term changes cannot sufficiently be assessed through in-situ forest inventories as they usually have repetition periods of multiple years. Furthermore, numerous FH indicators monitored in in-situ surveys are based on expert judgement. Remote sensing (RS technologies offer means to monitor FH indicators in an effective, repetitive and comparative way. This paper reviews techniques that are currently used for monitoring, including close-range RS, airborne and satellite approaches. The implementation of optical, RADAR and LiDAR RS-techniques to assess spectral traits/spectral trait variations (ST/STV is described in detail. We found that ST/STV can be used to record indicators of FH based on RS. Therefore, the ST/STV approach provides a framework to develop a standardized monitoring concept for FH indicators using RS techniques that is applicable to future monitoring programs. It is only through linking in-situ and RS approaches that we will be able to improve our understanding of the relationship between stressors, and the associated spectral responses in order to develop robust FH indicators.

  16. Uma visão integrada do modelo teaching games for understanding: adequando os estilos de ensino e questionamento à realidade da educação física

    Directory of Open Access Journals (Sweden)

    Filipe Manuel Clemente

    2014-04-01

    Full Text Available O modelo Teaching Games for Understanding (TGfU reveste-se de importância na atualidade, afigurando-se como um modelo de ensino com potencialidades evidentes para o desenvolvimento integral dos alunos. No entanto, o investimento recente da investigação tem se centrado no desenvolvimento das formas de jogo e na teorização da sua aplicação sendo que fatores complementares do modelo, tais como, os estilos de ensino adotados e o tipo de questionamento apresentam menor desenvolvimento teórico. Nesse sentido, o presente trabalho propõe-se a analisar a relevância dos estilos de ensino e do questionamento como ferramentas pedagógicas que conferem real valor pedagógico ao modelo de ensino.

  17. Towards a New Understanding of the e-Business Strategic Process: The Rise of a Dynamic Interaction-Based Approach

    DEFF Research Database (Denmark)

    Ivang, Reimer

    2013-01-01

    to explain how companies could strategize in the field of ICT and e-business. Strategic information systems planning (SISP) is an example of this application of strategic planning in the field of e-business. The prominence of SISP within the corporate IS strategy literature has been dramatic, but today...... there exist other different understandings of how strategies are emerging. However, e-business strategic literature is still dominated by the planning e-business approaches. The question therefore remains: Is it still optimal to build a static, programmed analytical information plan, or must the e-business...... strategic process adapt to changes in the planning environment and internal changes within the organization? E-business strategy, because of increased uncertainty and environmental complexity, must encourage interaction between key stakeholders that implement and use the e-business technology...

  18. Self-organizing maps in geothermal exploration-A new approach for understanding geochemical processes and fluid evolution

    Science.gov (United States)

    Brehme, Maren; Bauer, Klaus; Nukman, Mochamad; Regenspurg, Simona

    2017-04-01

    Understanding geochemical processes is an important part of geothermal exploration to get information about the source and evolution of geothermal fluids. However, in most cases knowledge of fluid properties is based on few parameters determined in samples from the shallow subsurface. This study presents a new approach that allows to conclude from the combination of a variety of these data on processes occurring at depth in a geothermal reservoir. The neural network clustering technique called "self-organizing maps" (SOMs) successfully distinguished two different geothermal settings based on a hydrochemical database and disclosed the source, evolution and flow pathways of geothermal fluids. Scatter plots, as shown in this study, are appropriate presentations of element concentrations and the chemical interaction of water and rock at depth. One geological setting presented here is marked by fault dominated fluid pathways and minor influence of volcanic affected fluids with high concentrations of HCO3, Ca and Sr. The second is a magmatically dominated setting showing strong alteration features in volcanic rocks and accommodates acidic fluids with high SO4 and Si concentrations. Former studies, i.e., Giggenbach (1988), suggested Cl, HCO3 and SO4 to be generally the most important elements for understanding hydrochemical processes in geothermal reservoirs. Their relation has been widely used to classify different water types in geothermal fields. However, this study showed that non-standard elements are at least of same importance to reveal different fluid types in geothermal systems. Therefore, this study is an extended water classification approach using SOM for element correlations. SOM have been proven to be a successful method for analyzing even relatively small hydrochemical datasets in geothermal applications.

  19. Pushing the boundaries of research on human resources for health: fresh approaches to understanding health worker motivation.

    Science.gov (United States)

    Bhatnagar, Aarushi; Scott, Kerry; Govender, Veloshnee; George, Asha

    2018-04-01

    A country's health workforce plays a vital role not only in serving the health needs of the population but also in supporting economic prosperity. Moreover, a well-funded and well-supported health workforce is vital to achieving universal health coverage and Sustainable Development Goal 3 to ensure healthy lives and promote well-being for all at all ages. This perspective article highlights the potential of underutilized health policy and systems research (HPSR) approaches for developing more effective human resources for health policy. The example of health worker motivation is used to showcase four types of HPSR (exploratory, influence, explanatory and emancipatory) that move beyond describing the extent of a problem. Most of the current literature aiming to understand determinants and dynamics of motivation is descriptive in nature. While this is an important basis for all research pursuits, it often gives little information about mechanisms to improve motivation and strategies for intervention. Motivation is an essential determinant of health worker performance, particularly for those working in difficult conditions, such as those facing many health workers in low- and middle-income countries. Motivation mediates health workforce performance in multiple ways: internally governing health worker behaviour; informing decisions on becoming a health worker; workplace location and ability to perform; and influencing willingness to engage politically. The four fresh research approaches described can help policy-makers better understand why health workers behave the way they do, how interventions can improve performance, the mechanisms that lead to change, and strategies for empowering health workers to be agents of change themselves.

  20. The GLOBE Carbon Cycle Project: Using a systems approach to understand carbon and the Earth's climate system

    Science.gov (United States)

    Silverberg, S. K.; Ollinger, S. V.; Martin, M. E.; Gengarelly, L. M.; Schloss, A. L.; Bourgeault, J. L.; Randolph, G.; Albrechtova, J.

    2009-12-01

    National Science Content Standards identify systems as an important unifying concept across the K-12 curriculum. While this standard exists, there is a recognized gap in the ability of students to use a systems thinking approach in their learning. In a similar vein, both popular media as well as some educational curricula move quickly through climate topics to carbon footprint analyses without ever addressing the nature of carbon or the carbon cycle. If students do not gain a concrete understanding of carbon’s role in climate and energy they will not be able to successfully tackle global problems and develop innovative solutions. By participating in the GLOBE Carbon Cycle project, students learn to use a systems thinking approach, while at the same time, gaining a foundation in the carbon cycle and it's relation to climate and energy. Here we present the GLOBE Carbon Cycle project and materials, which incorporate a diverse set of activities geared toward upper middle and high school students with a variety of learning styles. A global carbon cycle adventure story and game let students see the carbon cycle as a complete system, while introducing them to systems thinking concepts including reservoirs, fluxes and equilibrium. Classroom photosynthesis experiments and field measurements of schoolyard vegetation brings the global view to the local level. And the use of computer models at varying levels of complexity (effects on photosynthesis, biomass and carbon storage in global biomes, global carbon cycle) not only reinforces systems concepts and carbon content, but also introduces students to an important scientific tool necessary for understanding climate change.

  1. Understanding academic clinicians' varying attitudes toward the treatment of childhood obesity in Canada: a descriptive qualitative approach.

    Science.gov (United States)

    Bailey, Karen; Pemberton, Julia; Frankfurter, Claudia

    2013-05-01

    This qualitative study aims to understand academic physicians' attitudes towards the treatment of pediatric obesity in Canada. A stratified sample of 24 participants (surgeons, pediatricians, family practitioners) were recruited from 4 Canadian regions. Semi-structured interviews were conducted and transcribed. A codebook was developed through iterative data reduction and conceptual saturation ensured. Validity was ensured through triangulation, audit trail, and member-checking. This study revealed 45 themes with regional, specialty, and experiential differences. Quebec and Ontario emphasized education of physicians and parents to improve treatment and favored surgical intervention. Half of surgeons felt surgery was the only successful treatment option, while non-surgeons favored behavioral interventions. Experienced physicians in Western Canada desired more evidence to improve patient care, while inexperienced physicians focused on early detection and home environments. Across Canada participants advocated for program development and system change. Respondents expressed family involvement as integral to treatment success and shifting away from blame and moving towards a healthy lifestyles approach. Canadian regional differences in physicians' attitudes towards pediatric obesity treatment exist, influenced by experience and specialty. We will understand how themes identified in this study influence real life clinical decision making by applying these results to create a discrete choice-based conjoint survey. Copyright © 2013 Elsevier Inc. All rights reserved.

  2. Radioactivity and the environment: technical approaches to understand the role of arbuscular mycorrhizal plants in radionuclide bioaccumulation

    Science.gov (United States)

    Davies, Helena S.; Cox, Filipa; Robinson, Clare H.; Pittman, Jon K.

    2015-01-01

    Phytoaccumulation of radionuclides is of significant interest with regards to monitoring radionuclide build-up in food chains, developing methods for environmental bioremediation and for ecological management. There are many gaps in our understanding of the characteristics and mechanisms of plant radionuclide accumulation, including the importance of symbiotically-associated arbuscular mycorrhizal (AM) fungi. We first briefly review the evidence that demonstrates the ability of AM fungi to enhance the translocation of 238U into plant root tissues, and how fungal association may prevent further mobilization into shoot tissues. We then focus on approaches that should further advance our knowledge of AM fungi–plant radionuclide accumulation. Current research has mostly used artificial cultivation methods and we consider how more ecologically-relevant analysis might be performed. The use of synchrotron-based X-ray fluorescence imaging and absorption spectroscopy techniques to understand the mechanisms of radionuclide transfer from soil to plant via AM fungi is evaluated. Without such further knowledge, the behavior and mobilization of radionuclides cannot be accurately modeled and the potential risks cannot be accurately predicted. PMID:26284096

  3. Comparison of two different techniques of cooperative learning approach: Undergraduates' conceptual understanding in the context of hormone biochemistry.

    Science.gov (United States)

    Mutlu, Ayfer

    2018-03-01

    The purpose of the research was to compare the effects of two different techniques of the cooperative learning approach, namely Team-Game Tournament and Jigsaw, on undergraduates' conceptual understanding in a Hormone Biochemistry course. Undergraduates were randomly assigned to Group 1 (N = 23) and Group 2 (N = 29). Instructions were accomplished using Team-Game Tournament in Group 1 and Jigsaw in Group 2. Before the instructions, all groups were informed about cooperative learning and techniques, their responsibilities in the learning process and accessing of resources. Instructions were conducted under the guidance of the researcher for nine weeks and the Hormone Concept Test developed by the researcher was used before and after the instructions for data collection. According to the results, while both techniques improved students' understanding, Jigsaw was more effective than Team-Game Tournament. © 2017 by The International Union of Biochemistry and Molecular Biology, 46(2):114-120, 2018. © 2017 The International Union of Biochemistry and Molecular Biology.

  4. Towards a system level understanding of non-model organisms sampled from the environment: a network biology approach.

    Directory of Open Access Journals (Sweden)

    Tim D Williams

    2011-08-01

    Full Text Available The acquisition and analysis of datasets including multi-level omics and physiology from non-model species, sampled from field populations, is a formidable challenge, which so far has prevented the application of systems biology approaches. If successful, these could contribute enormously to improving our understanding of how populations of living organisms adapt to environmental stressors relating to, for example, pollution and climate. Here we describe the first application of a network inference approach integrating transcriptional, metabolic and phenotypic information representative of wild populations of the European flounder fish, sampled at seven estuarine locations in northern Europe with different degrees and profiles of chemical contaminants. We identified network modules, whose activity was predictive of environmental exposure and represented a link between molecular and morphometric indices. These sub-networks represented both known and candidate novel adverse outcome pathways representative of several aspects of human liver pathophysiology such as liver hyperplasia, fibrosis, and hepatocellular carcinoma. At the molecular level these pathways were linked to TNF alpha, TGF beta, PDGF, AGT and VEGF signalling. More generally, this pioneering study has important implications as it can be applied to model molecular mechanisms of compensatory adaptation to a wide range of scenarios in wild populations.

  5. Understanding small biomolecule-biomaterial interactions: a review of fundamental theoretical and experimental approaches for biomolecule interactions with inorganic surfaces.

    Science.gov (United States)

    Costa, Dominique; Garrain, Pierre-Alain; Baaden, Marc

    2013-04-01

    Interactions between biomolecules and inorganic surfaces play an important role in natural environments and in industry, including a wide variety of conditions: marine environment, ship hulls (fouling), water treatment, heat exchange, membrane separation, soils, mineral particles at the earth's surface, hospitals (hygiene), art and buildings (degradation and biocorrosion), paper industry (fouling) and more. To better control the first steps leading to adsorption of a biomolecule on an inorganic surface, it is mandatory to understand the adsorption mechanisms of biomolecules of several sizes at the atomic scale, that is, the nature of the chemical interaction between the biomolecule and the surface and the resulting biomolecule conformations once adsorbed at the surface. This remains a challenging and unsolved problem. Here, we review the state of art in experimental and theoretical approaches. We focus on metallic biomaterial surfaces such as TiO(2) and stainless steel, mentioning some remarkable results on hydroxyapatite. Experimental techniques include atomic force microscopy, surface plasmon resonance, quartz crystal microbalance, X-ray photoelectron spectroscopy, fluorescence microscopy, polarization modulation infrared reflection absorption spectroscopy, sum frequency generation and time of flight secondary ion mass spectroscopy. Theoretical models range from detailed quantum mechanical representations to classical forcefield-based approaches. Copyright © 2012 Wiley Periodicals, Inc.

  6. Where Lies the Risk? An Ecological Approach to Understanding Child Mental Health Risk and Vulnerabilities in Sub-Saharan Africa

    Science.gov (United States)

    Atilola, Olayinka

    2014-01-01

    Efforts at improving child-health and development initiatives in sub-Saharan Africa had focused on the physical health of children due to the neglect of child and adolescent mental health (CAMH) policy initiatives. A thorough and broad-based understanding of the prevalent child mental-health risk and vulnerability factors is needed to successfully articulate CAMH policies. In this discourse, we present a narrative on the child mental-health risk and vulnerability factors in sub-Saharan Africa. Through an ecological point of view, we identified widespread family poverty, poor availability and uptake of childcare resources, inadequate community and institutional childcare systems, and inadequate framework for social protection for vulnerable children as among the risk and vulnerability factors for CAMH in the region. Others are poor workplace policy/practice that does not support work-family life balance, poor legislative framework for child protection, and some harmful traditional practices. We conclude that an ecological approach shows that child mental-health risks are diverse and cut across different layers of the care environment. The approach also provides a broad and holistic template from which appropriate CAMH policy direction in sub-Saharan Africa can be understood. PMID:24834431

  7. Where lies the risk? An ecological approach to understanding child mental health risk and vulnerabilities in sub-saharan Africa.

    Science.gov (United States)

    Atilola, Olayinka

    2014-01-01

    Efforts at improving child-health and development initiatives in sub-Saharan Africa had focused on the physical health of children due to the neglect of child and adolescent mental health (CAMH) policy initiatives. A thorough and broad-based understanding of the prevalent child mental-health risk and vulnerability factors is needed to successfully articulate CAMH policies. In this discourse, we present a narrative on the child mental-health risk and vulnerability factors in sub-Saharan Africa. Through an ecological point of view, we identified widespread family poverty, poor availability and uptake of childcare resources, inadequate community and institutional childcare systems, and inadequate framework for social protection for vulnerable children as among the risk and vulnerability factors for CAMH in the region. Others are poor workplace policy/practice that does not support work-family life balance, poor legislative framework for child protection, and some harmful traditional practices. We conclude that an ecological approach shows that child mental-health risks are diverse and cut across different layers of the care environment. The approach also provides a broad and holistic template from which appropriate CAMH policy direction in sub-Saharan Africa can be understood.

  8. Where Lies the Risk? An Ecological Approach to Understanding Child Mental Health Risk and Vulnerabilities in Sub-Saharan Africa

    Directory of Open Access Journals (Sweden)

    Olayinka Atilola

    2014-01-01

    Full Text Available Efforts at improving child-health and development initiatives in sub-Saharan Africa had focused on the physical health of children due to the neglect of child and adolescent mental health (CAMH policy initiatives. A thorough and broad-based understanding of the prevalent child mental-health risk and vulnerability factors is needed to successfully articulate CAMH policies. In this discourse, we present a narrative on the child mental-health risk and vulnerability factors in sub-Saharan Africa. Through an ecological point of view, we identified widespread family poverty, poor availability and uptake of childcare resources, inadequate community and institutional childcare systems, and inadequate framework for social protection for vulnerable children as among the risk and vulnerability factors for CAMH in the region. Others are poor workplace policy/practice that does not support work-family life balance, poor legislative framework for child protection, and some harmful traditional practices. We conclude that an ecological approach shows that child mental-health risks are diverse and cut across different layers of the care environment. The approach also provides a broad and holistic template from which appropriate CAMH policy direction in sub-Saharan Africa can be understood.

  9. Systematic Understanding of Mechanisms of a Chinese Herbal Formula in Treatment of Metabolic Syndrome by an Integrated Pharmacology Approach.

    Science.gov (United States)

    Chen, Meimei; Yang, Fafu; Yang, Xuemei; Lai, Xinmei; Gao, Yuxing

    2016-12-16

    Metabolic syndrome (MS) is becoming a worldwide health problem. Wendan decoction (WDD)-a famous traditional Chinese medicine formula-has been extensively employed to relieve syndromes related to MS in clinical practice in China. However, its pharmacological mechanisms still remain vague. In this study, a comprehensive approach that integrated chemomics, principal component analysis, molecular docking simulation, and network analysis was established to elucidate the multi-component and multi-target mechanism of action of WDD in treatment of MS. The compounds in WDD were found to possess chemical diversity, complexity and drug-likeness compared to MS drugs. Six nuclear receptors were obtained to have strong binding affinity with 217 compounds of five herbs in WDD. The importance roles of targets and herbs were also identified due to network parameters. Five compounds from Radix Glycyrrhizae Preparata can hit all six targets, which can assist in screening new MS drugs. The pathway network analysis demonstrated that the main pharmacological effects of WDD might lie in maintaining lipid and glucose metabolisms and anticancer activities as well as immunomodulatory and hepatoprotective effects. This study provided a comprehensive system approach for understanding the multi-component, multi-target and multi-pathway mechanisms of WDD during the treatment of MS.

  10. Systematic Understanding of Mechanisms of a Chinese Herbal Formula in Treatment of Metabolic Syndrome by an Integrated Pharmacology Approach

    Directory of Open Access Journals (Sweden)

    Meimei Chen

    2016-12-01

    Full Text Available Metabolic syndrome (MS is becoming a worldwide health problem. Wendan decoction (WDD—a famous traditional Chinese medicine formula—has been extensively employed to relieve syndromes related to MS in clinical practice in China. However, its pharmacological mechanisms still remain vague. In this study, a comprehensive approach that integrated chemomics, principal component analysis, molecular docking simulation, and network analysis was established to elucidate the multi-component and multi-target mechanism of action of WDD in treatment of MS. The compounds in WDD were found to possess chemical diversity, complexity and drug-likeness compared to MS drugs. Six nuclear receptors were obtained to have strong binding affinity with 217 compounds of five herbs in WDD. The importance roles of targets and herbs were also identified due to network parameters. Five compounds from Radix Glycyrrhizae Preparata can hit all six targets, which can assist in screening new MS drugs. The pathway network analysis demonstrated that the main pharmacological effects of WDD might lie in maintaining lipid and glucose metabolisms and anticancer activities as well as immunomodulatory and hepatoprotective effects. This study provided a comprehensive system approach for understanding the multi-component, multi-target and multi-pathway mechanisms of WDD during the treatment of MS.

  11. Topological Characteristics of the Hong Kong Stock Market: A Test-based P-threshold Approach to Understanding Network Complexity

    Science.gov (United States)

    Xu, Ronghua; Wong, Wing-Keung; Chen, Guanrong; Huang, Shuo

    2017-02-01

    In this paper, we analyze the relationship among stock networks by focusing on the statistically reliable connectivity between financial time series, which accurately reflects the underlying pure stock structure. To do so, we firstly filter out the effect of market index on the correlations between paired stocks, and then take a t-test based P-threshold approach to lessening the complexity of the stock network based on the P values. We demonstrate the superiority of its performance in understanding network complexity by examining the Hong Kong stock market. By comparing with other filtering methods, we find that the P-threshold approach extracts purely and significantly correlated stock pairs, which reflect the well-defined hierarchical structure of the market. In analyzing the dynamic stock networks with fixed-size moving windows, our results show that three global financial crises, covered by the long-range time series, can be distinguishingly indicated from the network topological and evolutionary perspectives. In addition, we find that the assortativity coefficient can manifest the financial crises and therefore can serve as a good indicator of the financial market development.

  12. Bridging the Research to Practice Gap: A Case Study Approach to Understanding EIBI Supports and Barriers in Swedish Preschools

    Directory of Open Access Journals (Sweden)

    Lise ROLL-PETTERSSON

    2016-12-01

    Full Text Available The present study examined proximal and distal barriers and supports within the Swedish service system that may affect implementation of early and intensive behavioral intervention (EIBI for children with autism. A case study approach with roots in ethnography was chosen to explore this issue. Two preschools exemplifying ‘high quality practice’ were studied and information was collected through multiple sources during a 12 month period, this included participant observations, direct observations, semi-structured interviews with key informants; paraprofessionals, parents, special educators, habilitation specialists and a focus group interview. Interview transcripts and field notes were combined and analyzed using an abductive grounded theory approach. Findings highlight the relevance of researchers understanding and taking into consideration the effect that distal variables have on implementation within proximal settings. A theoretical model of factors affecting implementation was conceptualised to include: staff entry knowledge and competence, development through supervision, the role of the preschool administrator, as well as distal influences and inter-organizational tensions, values, and bridges. Findings are discussed within the context of implementation science. Implications for future research are discussed as well as areas in need of further development to bridge the gap between research and practice.

  13. A multi-diagnostic approach to understanding high-latitude plasma transport during the Halloween 2003 storm

    Directory of Open Access Journals (Sweden)

    P. Yin

    2008-09-01

    Full Text Available During the Halloween 2003 storm event, significant electron density enhancements at elevated F-layer altitudes were recorded by the EISCAT and ESR radars in northern Europe between 20:00 and 24:00 UT on 30 October. At the same time, a sequence of optical images from Qaanaaq in northern Greenland captured a series of eastward-propagating polar cap patches. In this paper, an advanced 4-D tomographic method based on the assimilation of global GPS data, coupled to a predictive Kalman filtering technique, has been used to reveal the linkage between these ionospheric structures. The combination of the various data sources has clearly established the time history of this extreme event, in which high-density plasma was uplifted in the dayside ionosphere and convected anti-sunward across the polar cap to European high latitudes at an elevated F-layer. Using this multi instrument approach, we can differentiate between those density structures observed at the ESR which occurred as a result of cross-polar transport and those more likely to have been produced by in-situ soft particle precipitation, a distinction which is supported by the ESR and EISCAT data. The multi-diagnostic approach reported here has the potential significantly to extend our current understanding of high latitude plasma transport and the origin of electron density enhancements.

  14. To do good might hurt bad: exploring nurses' understanding and approach to suffering in forensic psychiatric settings.

    Science.gov (United States)

    Vincze, Mattias; Fredriksson, Lennart; Wiklund Gustin, Lena

    2015-04-01

    Patients in forensic psychiatric settings not only have to deal with their mental illness, but also memories of criminal activities and being involuntarily hospitalized. The aim of the present study was to explore how nurses working in forensic psychiatric services understand and approach patients' experiences of suffering. Data were generated by semistructured interviews with psychiatric nurses from two different forensic psychiatric units in Sweden. Data were analysed by means of a hermeneutic approach inspired by Ricoeur's hermeneutics. The findings are reflected in four main themes: (i) ignoring suffering; (ii) explaining suffering as a natural and inevitable part of daily life in the forensic context; (iii) ascribing meaning to suffering; and, (iv) being present in suffering. To engage in alleviating suffering is a struggle that demands courage and the strength to reflect on its character and consequences. To encounter suffering means that nurses are not only confronted with patients' suffering, but also their own reactions to those patients. If suffering is not recognized or encountered, there is a risk that actions may have a negative impact on patients. © 2015 Australian College of Mental Health Nurses Inc.

  15. Effect of problem based approach on medical students’ learning satisfaction and understanding in the histology course topics

    Directory of Open Access Journals (Sweden)

    MJ Rezaie

    2013-05-01

    Full Text Available Background and purpose: Problem-based learning (PBL is a term used within education for a range of teaching approaches that encourage students to learn through the structured exploration of a problem. Histology comes early in the curriculum and the medical students seem unable to see the value of the content, they don't appear to be motivated to learn the content. This project used PBL to help the students make the connection between the content and clinical aspects.Methods: Thirty six undergraduate medical students, 22 female and 14 male, enrolled in the histology course during the spring semester of 2008. A survey which collected information relative to gender, course load, and workload and study time was used. The subjects were accessory glands of digestive system histology. The course is designed into four units: tree units of salivary glands, pancreas and gall bladder histology, were presented in a traditional lecture format; the fourth unit, liver was presented in a problem-based format that used clinical practice. Assessment focused on three issues of a. student engagement, b. lesson assessment in terms of clarity, interest and usefulness and c. student understanding.Results: Student comments collected during PBL class periods indicate engagement in the topic. In PBL method of teaching most of responses were consistent with the aim of teaching but in traditional classes few responses relate to the objectives at hand. Students had more active partnership in PBL class. Students found PBL class more useful, interesting and clear in terms of subject material than traditional method.Conclusions: In this project student comments collected during PBL class periods indicated more engagement in the topic. Students’ understanding of material were significantly higher and students’ partnership in PBL class was more than traditional classes.Keywords: PBL,HISTOLOGY, STUDENT PARTICIPATION

  16. An Integrative Observing and Modeling Approach for the Physiological Understanding of Sun-Induced Chlorophyll Fluorescence in Japan

    Science.gov (United States)

    Kobayashi, H.; Kato, T.; Saitoh, Y.; Noda, H.; Kikosaka, K.; Ichii, K.; Nasahara, K. N.

    2016-12-01

    Satellite-derived sun-induced chlorophyll fluorescence (SIF) is expected to provides a pathway to link leaf level photosynthesis to global GPP. Existing studies have stressed how well the satellite-derived SIF is correlated with the eddy covariance and/or modeled GPPs. There are some challenges in SIF interpretation because the satellite-derived SIF is a mixture of fluorescence emission from sunlit and shaded leaves and multiple scatterings of fluorescence within plant canopies. In this presentation, we show observation and modeling results around Japan and discuss how the integrative observing and modeling approach potentially overcomes the gaps in-between satellite SIF and photosynthesis reaction within leaves. We have analyzed ground-based SIF monitoring systems "Phenological Eye Network (PEN)". PEN covers several eddy flux sites in Japan and is equipped with spectroradiometer (MS-700) since 2003 (at an earliest site). The computed seasonal SIF variations in the different ecosystems show environmental dependency of SIF and GPP. Another ground-based system we are now developing is the vegetation lidar system named LIFS (Laser-Induced Fluorescence Spectrum), which can offer eco-physiological information of plants. LIFS is consisted of a pulsed UV (355 nm) laser, a telescope, a spectrometer/filter, and a gated image-intensified CCD detector. This system has been using to remotely monitor tree growth status, chlorophyll contents in leaves and so on. The physical and physiological theories are necessary for understanding the observed SIF under various environmental conditions. We have been developing leaf to plant canopy scale photosynthesis and SIF models as precise as possible. The developed model has been used to understand how the leaf-level SIF emission can be related to the canopy scale SIF, which enables to investigate the top of canopy SIF observed from ground-based and satellite-derived SIF measurements.

  17. What the Dynamic Systems Approach Can Offer for Understanding Development: An Example of Mid-childhood Reaching.

    Science.gov (United States)

    Golenia, Laura; Schoemaker, Marina M; Otten, Egbert; Mouton, Leonora J; Bongers, Raoul M

    2017-01-01

    The Dynamic Systems Approach (DSA) to development has been shown to be a promising theory to understand developmental changes. In this perspective, we use the example of mid-childhood (6- to 10-years of age) reaching to show how using the DSA can advance the understanding of development. Mid-childhood is an important developmental period that has often been overshadowed by the focus on the acquisition of reaching during infancy. This underrepresentation of mid-childhood studies is unjustified, as earlier studies showed that important developmental changes in mid-childhood reaching occur that refine the skill of reaching. We review these studies here for the first time and show that different studies revealed different developmental trends, such as non-monotonic and linear trends, for variables such as movement time and accuracy at target. Unfortunately, proposed explanations for these developmental changes have been tailored to individual studies, limiting their scope. Also, explanations were focused on a single component or process in the system that supposedly causes developmental changes. Here, we propose that the DSA can offer an overarching explanation for developmental changes in this research field. According to the DSA, motor behavior emerges from interactions of multiple components entailed by the person, environment, and task. Changes in all these components can potentially contribute to the emerging behavior. We show how the principles of change of the DSA can be used as an overarching framework by applying these principles not only to development, but also the behavior itself. This underlines its applicability to other fields of development.

  18. From observation to understanding: Approach to analysis of wear mechanisms, Case of RCCAs and CRDM latch arms

    International Nuclear Information System (INIS)

    Hertz, D.

    2004-01-01

    Component wear can affect the ability of a component to fulfill its required function. For a designer or user, it is reasonable to expect possible wear occurrence as soon as parts are in relative motion. It is less obvious to extend this possibility to motions with small or very small amplitudes and loads. However, it has to be admitted that such cases exist. It then becomes imperative to determine the wear mechanisms so that the lifetime of the components and the optimum date of their replacement can be predicted or the degradation can be remedied. For this purpose, standard and widely accepted practice is to carry out simulator tests. Through examples of wear from nuclear reactor components such as the RCCAs (Rod Cluster Control Assembly) and the CRDM (Control Rod Drive Mechanism) latch arms, an approach for understanding the wear mechanisms and controlling their effects can be undertaken. Cases of wear have been observed on real-life parts, but the first simulator tests have shown deviations from in-reactor behaviour. Comparative examination of the wear facies of actual parts which have operated in reactor or simulators, both control rods and CRDM latch arms, was the key starting point for a new analytical approach, incorporating the formulation of wear mechanism hypotheses which can account for the observed facies. Expert assessment thus highlighted the importance of the environment by revealing that the wear featured a large component linked to friction-assisted corrosion. By including this tribo-corrosion aspect, it became possible to reach understanding of the mechanisms and account for the wear observed in reactor and on simulators. Further well-controlled simulator tests then made it possible to verify the importance of the tribo-corrosion processes in a pressurized water medium. Analysis of the physical chemical behaviour of the original materials (austenitic stainless steel) also explains why these surface modifications limit or remedy wear

  19. An Integrated Approach for Understanding Anthropogenic and Climatic Impacts on Lakes: A Case study from Lake Iznik, Turkey

    Science.gov (United States)

    Derin, Y.; Milewski, A.; Fryar, A. E.; Schroeder, P.

    2013-12-01

    Lakes are among the most vital natural water resource, providing many environmental and economic advantages to a region. Unfortunately, many lakes are disappearing or continue to be polluted as industrial and agricultural practices increase to keep pace with rising populations. Lake Iznik, the biggest lake (approximately 300 km2) in the Marmara Region in Turkey, is a significant water resource as it provides opportunities for recreational activities, agriculture, industry, and water production for the region. However, rapid population growth combined with poor land management practices in this water basin has contributed to decreased water quality and water levels. As a result, Lake Iznik has switched from being Mesotrophic to Eutrophic in the past thirty years. This research aims to understand both the anthropogenic and climatic impacts on Lake Iznik. An integrated approach combining satellite remote sensing, hydrogeology, hydrologic modeling, and climatology was utilized to identify the source and timing responsible for the decline in water quality and quantity. Specifically, Landsat TM images from 1990, 2000, 2005, and 2010 were collected, processed, and analyzed for changes in landuse/landcover and surface area extent of Lake Iznik. Water level and water quality data (e.g. streamflow, lake level, pH, conductivity, total nitrogen, total dissolved solid etc.) collected from the General Directorate of State Hydraulic Works (DSI) from 1980-2012 were obtained from 4 stations and compared to the Landsat landuse mosaics. Meteorological data collected from Turkish State Meteorological Service from 1983-2012 were obtained from 3 stations (precipitation, temperature, atmospheric pressure, relative humidity, vapor pressure, wind speed and pan evaporation). A hydrologic model using MIKE21 was constructed to measure the change in streamflow and subsequent lake level as a result of changes in both land use and climate. Results have demonstrated the drop in water level from

  20. Hypoxia monitoring activities within the FP7 EU-project HYPOX: diverse approaches to understand a complex phenomenon

    Science.gov (United States)

    Janssen, F.; Waldmann, C.; Boetius, A.

    2012-04-01

    Hypoxic conditions in aquatic systems and the occurrence of 'dead zones' increase worldwide due to man-made eutrophication and global warming with consequences for biodiversity, ecosystem functions and services such as fisheries, aquaculture and tourism. Monitoring of hypoxia and its consequences has to (1) account for the appropriate temporal and spatial scales, (2) separate anthropogenic from natural drivers and long-term trends from natural variations, (3) assess ecosystem response, (4) use modeling tools for generalization and prediction, and (5) share data and obtained knowledge. In 2009 the EU FP7 project HYPOX (www.hypox.net) started out as a pioneering attempt to improve and integrate hypoxia observation capacities addressing these requirements. Target ecosystems selected for HYPOX cover a broad range of settings (e.g., hydrography, oxygenation status, biological activity, anthropogenic impact) and differ in their sensitivity towards change. Semi-enclosed basins with permanent anoxia (Black Sea, Baltic Sea), are included as well as seasonally or locally hypoxic land-locked systems (fjords, lagoons, lakes) and open ocean systems with high sensitivity to global warming (North Atlantic - Arctic transition). Adopted monitoring approaches involve autonomous, cabled, and shipboard instruments and include static and profiling moorings, benthic observatories, drifters, as well as classical CTD surveys. In order to improve observatory performance, project activities encompass developments of oxygen sensors as well as calibration procedures and technologies to reduce biofouling. Modeling and data assimilation are used to synthesize findings, to obtain an in-depth understanding of hypoxia causes and consequences, and to improve forecasting capacities. For integration of the collected information into a global oxygen observing system, results are disseminated through the HYPOX portal following GEOSS data sharing principles. This presentation will give an overview of

  1. An Approach to Understanding Complex Socio-Economic Impacts and Responses to Climate Disruption in the Chesapeake Bay Region

    Science.gov (United States)

    Schaefer, R. K.; Nix, M.; Ihde, A. G.; Paxton, L. J.; Weiss, M.; Simpkins, S.; Fountain, G. H.; APl GAIA Team

    2011-12-01

    In this paper we describe the application of a proven methodology for modeling the complex social and economic interactions of a system under stress to the regional issues that are tied to global climate disruption. Under the auspices of the GAIA project (http://gaia.jhuapl.edu), we have investigated simulating the complex interplay between climate, politics, society, industry, and the environment in the Chesapeake Bay Watershed and associated geographic areas of Maryland, Virginia, and Pennsylvania. This Chesapeake Bay simulation draws on interrelated geophysical and climate models to support decision-making analysis about the Bay. In addition to physical models, however, human activity is also incorporated via input and output calculations. For example, policy implications are modeled in relation to business activities surrounding fishing, farming, industry and manufacturing, land development, and tourism. This approach fosters collaboration among subject matter experts to advance a more complete understanding of the regional impacts of climate change. Simulated interactive competition, in which teams of experts are assigned conflicting objectives in a controlled environment, allow for subject exploration which avoids trivial solutions that neglect the possible responses of affected parties. Results include improved planning, the anticipation of areas of conflict or high risk, and the increased likelihood of developing mutually acceptable solutions.

  2. A Community-Based Participatory Research Approach to Understand Urban Latino Parent’s Oral Health Knowledge and Beliefs

    Directory of Open Access Journals (Sweden)

    Tamanna Tiwari

    2017-01-01

    Full Text Available The aim of this study is to describe oral health knowledge, behaviors, and beliefs of Latino parents with children under the ages of 6 years and to conduct a needs assessment with Latino families to better understand the challenges in maintaining oral health for their children. The investigator collaborated with a community serving the organization to recruit Latino primary caregivers for focus groups interviews and 30 primary caregivers were recruited. The focus groups data was transcribed and analyzed using a grounded theory approach using QDA Miner software. Findings from the focus groups demonstrate that the primary caregivers described barriers in maintaining oral health for their children including cultural barriers, child’s temperament, lack of time, and easy access to high-risk foods. All participants said that they wanted to receive information on the oral health of their children; they wanted the dentist or the hygienist to demonstrate oral hygiene practices and explain to them the reasons for oral health behaviors. Although the primary caregivers recognized some factors related to caries development, their knowledge was limited in depth. Culturally appropriate oral health education is required for this population, which could lead to more adherent oral health behavior and a higher sense of self-efficacy in Latino parents.

  3. Preparing for smart grid technologies: A behavioral decision research approach to understanding consumer expectations about smart meters

    International Nuclear Information System (INIS)

    Krishnamurti, Tamar; Schwartz, Daniel; Davis, Alexander; Fischhoff, Baruch; Bruine de Bruin, Wändi; Lave, Lester; Wang, Jack

    2012-01-01

    With the enactment of the 2009 American Recovery and Reinvestment Act, U.S. President Obama made a public commitment to a new approach to energy production and transmission in the United States. It features installing smart meters and related technologies in residential homes, as part of transforming the current electrical grid into a “smart grid.” Realizing this transformation requires consumers to accept these new technologies and take advantage of the opportunities that they create. We use methods from behavioral decision research to understand consumer beliefs about smart meters, including in-depth mental models interviews and a follow-up survey with a sample of potential smart meter customers of a major U.S. mid-Atlantic electricity utility. In both the surveys and the interviews, most respondents reported wanting smart meters. However, these preferences were often based on erroneous beliefs regarding their purpose and function. Respondents confused smart meters with in-home displays and other enabling technologies, while expecting to realize immediate savings. They also perceived risks, including less control over their electricity usage, violations of their privacy, and increased costs. We discuss the policy implications of our results. - Highlights: ► We outline normative risks and benefits of smart meters from scientific literature. ► We examine consumer perceptions of smart meters via interviews and surveys. ► Smart meter desire stems from consumer misconceptions about purpose and function. ► Appropriate communications may prevent consumer protests against the smart grid.

  4. Novel targeted approach to better understand how natural structural barriers govern carotenoid in vitro bioaccessibility in vegetable-based systems.

    Science.gov (United States)

    Palmero, Paola; Lemmens, Lien; Ribas-Agustí, Albert; Sosa, Carola; Met, Kristof; de Dieu Umutoni, Jean; Hendrickx, Marc; Van Loey, Ann

    2013-12-01

    An experimental approach, allowing us to understand the effect of natural structural barriers (cell walls, chromoplast substructures) on carotenoid bioaccessibility, was developed. Different fractions with different levels of carotenoid bio-encapsulation (carotenoid-enriched oil, chromoplasts, small cell clusters, and large cell clusters) were isolated from different types of carrots and tomatoes. An in vitro method was used to determine carotenoid bioaccessibility. In the present work, a significant decrease in carotenoid in vitro bioaccessibility could be observed with an increasing level of bio-encapsulation. Differences in cell wall material and chromoplast substructure between matrices influenced carotenoid release and inclusion in micelles. For carrots, cell walls and chromoplast substructure were important barriers for carotenoid bioaccessibility while, in tomatoes, the chromoplast substructure represented the most important barrier governing bioaccessibility. The highest increase in carotenoid bioaccessibility, for all matrices, was obtained after transferring carotenoids into the oil phase, a system lacking cell walls and chromoplast substructures that could hamper carotenoid release. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. A data-model integration approach toward improved understanding on wetland functions and hydrological benefits at the catchment scale

    Science.gov (United States)

    Yeo, I. Y.; Lang, M.; Lee, S.; Huang, C.; Jin, H.; McCarty, G.; Sadeghi, A.

    2017-12-01

    The wetland ecosystem plays crucial roles in improving hydrological function and ecological integrity for the downstream water and the surrounding landscape. However, changing behaviours and functioning of wetland ecosystems are poorly understood and extremely difficult to characterize. Improved understanding on hydrological behaviours of wetlands, considering their interaction with surrounding landscapes and impacts on downstream waters, is an essential first step toward closing the knowledge gap. We present an integrated wetland-catchment modelling study that capitalizes on recently developed inundation maps and other geospatial data. The aim of the data-model integration is to improve spatial prediction of wetland inundation and evaluate cumulative hydrological benefits at the catchment scale. In this paper, we highlight problems arising from data preparation, parameterization, and process representation in simulating wetlands within a distributed catchment model, and report the recent progress on mapping of wetland dynamics (i.e., inundation) using multiple remotely sensed data. We demonstrate the value of spatially explicit inundation information to develop site-specific wetland parameters and to evaluate model prediction at multi-spatial and temporal scales. This spatial data-model integrated framework is tested using Soil and Water Assessment Tool (SWAT) with improved wetland extension, and applied for an agricultural watershed in the Mid-Atlantic Coastal Plain, USA. This study illustrates necessity of spatially distributed information and a data integrated modelling approach to predict inundation of wetlands and hydrologic function at the local landscape scale, where monitoring and conservation decision making take place.

  6. Unawareness to Production, Dropout to Innovator—Primary teachers' understanding and use of a science, technology and society approach to science teaching

    Science.gov (United States)

    Rollnick, Marissa; Dlamini, Betty T.; Bradley, John

    2015-05-01

    This paper investigates the process of teacher change in a group of 8 primary school teachers during their exposure to a science, technology and society (STS) approach to teaching Science in Swaziland. The research aimed to establish the effect of support given to teachers in using the approach through a series of workshops, followed by a 5-week supported implementation of the unit 'matter and energy'. An analysis of the way in which the STS approach impacted on the classroom practice of the teachers yielded 2 outcomes that were hierarchical. First, teacher understanding of the approach was observed to go through levels of unawareness, recognition of differences in approach, utilisation, personalisation and production. Second, the teachers' level of use of the STS approach was observed to have been affected by their levels of understanding, characterised by the following typologies: dropouts, strugglers, domesticators, succeeders and innovators. Some relationship between levels of understanding and typology of use was found, however, the level of understanding was not the exclusive determinant of typology of use. Only teachers reaching the utilisation level were able to use the innovation in a sustainable way, while those at the level of unawareness were able to become domesticators, adapting the innovation to their usual teaching approach.

  7. Understanding the biological effects of thorium in human cells and animals and developing efficient approaches for its decorporation and mitigation

    International Nuclear Information System (INIS)

    Kumar, Amit; Ali, Manjoor; Pandey, Badri N.

    2016-01-01

    Thorium-232 (Th) is being realized as a potential source of nuclear fuel for meeting long-term energy generation in India/other nations. In view of utilizing Th, it is hoped that mining, extraction, purification, back-end processing and disposal would increase significantly in near future. Therefore, understanding the biological effects of Th would enable its efficient utilization with adequate human health protection. Biological half-life and associated health effects of Th govern by its speciation, bio-kinetics, radiation decay and organ-specific accumulation due to Fe-like behaviour inside the body system. Our animal studies showed that Th mainly accumulates in liver and bone, in contrast to the accumulation of uranium in kidney. Cell culture experiments were performed to study the binding/internalization mechanism of Th (IV) with human liver cells (HepG2). Experiments using HepG2 cells suggested the role of transferrin (Tf), a blood protein in Th internalization. Recently, our in vitro study observed that the low concentration of Th nitrate induced proliferation in HepG2 through IGF-1R pathway. This study may have relevance to prevent early effects of Th using IGF-1 receptor-specific inhibitor. One of the major goals of our research group is to develop biological approaches for efficient decorporation of Th from liver. In this direction, liposomal form of DTPA has been optimized to effectively deliver DTPA to the liver. Testing of liposomal-DTPA in Th injected animal showed significant enhancement in removal of Th from liver and blood as compared to non-liposomal DTPA. Using ex-vivo human erythrocytes hemolysis assay and in whole blood condition, further efforts are in-progress to evaluate metal binding molecules in search of more effective decorporating agent than DTPA. In conclusion, this paper would discuss the results on mechanism of biological effects of Th on cells and proteins and newer molecules/approaches for its decorporation for human application

  8. Skeleton sled velocity profiles: a novel approach to understand critical aspects of the elite athletes' start phases.

    Science.gov (United States)

    Colyer, Steffi L; Stokes, Keith A; Bilzon, James L J; Salo, Aki I T

    2018-06-01

    The development of velocity across the skeleton start is critical to performance, yet poorly understood. We aimed to understand which components of the sled velocity profile determine performance and how physical abilities influence these components. Thirteen well-trained skeleton athletes (>85% of athletes in the country) performed dry-land push-starts alongside countermovement jump and sprint tests at multiple time-points. A magnet encoder attached to the sled wheel provided velocity profiles, which were characterised using novel performance descriptors. Stepwise regression revealed four variables (pre-load velocity, pre-load distance, load effectiveness, velocity drop) to explain 99% variance in performance (β weights: 1.70, -0.81, 0.25, -0.07, respectively). Sprint times and jump ability were associated (r ± 90% CI) with pre-load velocity (-0.70 ± 0.27 and 0.88 ± 0.14, respectively) and distance (-0.48 ± 0.39 and 0.67 ± 0.29, respectively), however, unclear relationships between both physical measures and load effectiveness (0.33 ± 0.44 and -0.35 ± 0.48, respectively) were observed. Athletes should develop accelerative ability to attain higher velocity earlier on the track. Additionally, the loading phase should not be overlooked and may be more influenced by technique than physical factors. Future studies should utilise this novel approach when evaluating skeleton starts or interventions to enhance performance.

  9. To use or not to use: a stage-based approach to understanding condom use among homeless youth.

    Science.gov (United States)

    Tucker, Joan S; Ober, Allison; Ryan, Gery; Golinelli, Daniela; Ewing, Brett; Wenzel, Suzanne L

    2014-01-01

    This study used a stage-based approach to understand condom use behavior in a representative sample of 309 sexually active homeless youth recruited from shelters, drop-in centers, and street sites in Los Angeles County. Focusing on the youth's most recent sexual event, the three stages of condom use examined were: (1) whether the partners decided prior to the event about using condoms; (2) whether a condom was available at the event; and (3) whether a condom was used at the event. Logistic regression analysis was used to identify attitudinal, relationship, and contextual correlates of each of these three stages. Deciding ahead of time about condom use was associated with being Hispanic, level of education, condom attitudes, and various relationship characteristics (e.g., partner type, monogamy, relationship abuse), with the nature of these associations varying depending on the type of decision (i.e., deciding to use, deciding to not use). Condom availability was more likely to be reported by males, if the event was described as being special in some way, or if the event lacked privacy. Condom use was more likely among youth with more positive condom attitudes and among youth who decide ahead of time to use a condom, but less likely among those in monogamous relationships or when hard drugs were used prior to sex. Whether sexual intercourse is protected or unprotected is the end result of a series of decisions and actions by sexual partners. Results from this study illustrate how condom use can be better understood by unpacking the stages and identifying influential factors at each stage. Each stage may, in and of itself, be an important target for intervention with homeless youth.

  10. Understanding transitions in care from hospital to homeless shelter: a mixed-methods, community-based participatory approach.

    Science.gov (United States)

    Greysen, S Ryan; Allen, Rebecca; Lucas, Georgina I; Wang, Emily A; Rosenthal, Marjorie S

    2012-11-01

    Coordinated transitions from hospital to shelter for homeless patients may improve outcomes, yet patient-centered data to guide interventions are lacking. To understand patients' experiences of transitions from hospital to a homeless shelter, and determine aspects of these experiences associated with perceived quality of these transitions. Mixed methods with a community-based participatory research approach, in partnership with personnel and clients from a homeless shelter. Ninety-eight homeless individuals at a shelter who reported at least one acute care visit to an area hospital in the last year. Using semi-structured interviews, we collected quantitative and qualitative data about transitions in care from the hospital to the shelter. We analyzed qualitative data using the constant comparative method to determine patients' perspectives on the discharge experience, and we analyzed quantitative data using frequency analysis to determine factors associated with poor outcomes from patients' perspective. Using qualitative analysis, we found homeless participants with a recent acute care visit perceived an overall lack of coordination between the hospital and shelter at the time of discharge. They also described how expectations of suboptimal coordination exacerbate delays in seeking care, and made three recommendations for improvement: 1) Hospital providers should consider housing a health concern; 2) Hospital and shelter providers should communicate during discharge planning; 3) Discharge planning should include safe transportation. In quantitative analysis of recent hospital experiences, 44 % of participants reported that housing status was assessed and 42 % reported that transportation was discussed. Twenty-seven percent reported discharge occurred after dark; 11 % reported staying on the streets with no shelter on the first night after discharge. Homeless patients in our community perceived suboptimal coordination in transitions of care from the hospital to the

  11. Parents' experiences of being in the Solihull Approach parenting group, 'Understanding Your Child's Behaviour': an interpretative phenomenological analysis.

    Science.gov (United States)

    Vella, L R; Butterworth, R E; Johnson, R; Law, G Urquhart

    2015-11-01

    Empirical evidence suggests that the Solihull Approach parenting group, 'Understanding Your Child's Behaviour' (UYCB), can improve child behaviour and parental well-being. However, little is known about parents' in-depth experience of participating in the UYCB programme. This study provides an in-depth qualitative evaluation of UYCB, focussing on possible moderating factors and mechanisms of change that may inform programme development. Ten parents (eight mothers and two fathers), recruited from seven UYCB groups across two locations, were interviewed within 7 weeks of completing the group and again 10 months later. Data were analysed using interpretative phenomenological analysis. Four themes were identified: 'Two Tiers of Satisfaction', 'Development as a Parent', 'Improved Self-belief' and 'The "Matthew Effect"'. In summary, the majority of parents were immensely satisfied at both completion and follow-up: they valued an experience of containment and social support and perceived improvement in specific child difficulties, their experience of parenting, their confidence and their coping. Most parents appeared to have developed more reflective and empathic parenting styles, with self-reported improved behaviour management. Theoretical material was well received, although some struggled with technical language. Positive outcomes appeared to be maintained, even reinforced, at follow-up, and were associated with having few initial child difficulties, perceiving improvement at completion and persevering with the recommendations. Two participants, whose children had the most severe difficulties, perceived deterioration and felt that the group was insufficient for their level of difficulties. Through in-depth analysis of parental experiences, UYCB appears to achieve its aims and communicate well its theoretical principles, although change may also occur through processes common to other group programmes (e.g. social support). Recommendations, stemming from the

  12. Understanding the influence of biofilm accumulation on the hydraulic properties of soils: a mechanistic approach based on experimental data

    Science.gov (United States)

    Carles Brangarí, Albert; Sanchez-Vila, Xavier; Freixa, Anna; Romaní, Anna M.; Fernàndez-Garcia, Daniel

    2017-04-01

    The distribution, amount, and characteristics of biofilms and its components govern the capacity of soils to let water through, to transport solutes, and the reactions occurring. Therefore, unraveling the relationship between microbial dynamics and the hydraulic properties of soils is of concern for the management of natural systems and many technological applications. However, the increased complexity of both the microbial communities and the geochemical processes entailed by them causes that the phenomenon of bioclogging remains poorly understood. This highlights the need for a better understanding of the microbial components such as live and dead bacteria and extracellular polymeric substances (EPS), as well as of their spatial distribution. This work tries to shed some light on these issues, providing experimental data and a new mechanistic model that predicts the variably saturated hydraulic properties of bio-amended soils based on these data. We first present a long-term laboratory infiltration experiment that aims at studying the temporal variation of selected biogeochemical parameters along the infiltration path. The setup consists of a 120-cm-high soil tank instrumented with an array of sensors plus soil and liquid samplers. Sensors measured a wide range of parameters in continuous, such as volumetric water content, electrical conductivity, temperature, water pressure, soil suction, dissolved oxygen, and pH. Samples were kept for chemical and biological analyses. Results indicate that: i) biofilm is present at all depths, denoting the potential for deep bioclogging, ii) the redox conditions profile shows different stages, indicating that the community was adapted to changing redox conditions, iii) bacterial activity, richness and diversity also exhibit zonation with depth, and iv) the hydraulic properties of the soil experienced significant changes as biofilm proliferated. Based on experimental evidences, we propose a tool to predict changes in the

  13. Understanding soil erosion process within herbaceous vegetative hedges using plant functional traits approach in North-West Europe

    Science.gov (United States)

    Kervroëdan, Léa; Armand, Romain; Saunier, Mathieu; Faucon, Michel-Pierre

    2017-04-01

    Runoff and soil erosion induce major environmental and economic damages. Concentrated runoff control by aboveground plant biomass in upstream areas constitutes a key feature to reduce runoff and soil erosion in Western Europe (WE). Indeed, aboveground plant biomass can reduce runoff and soil erosion respectively by increasing hydraulic roughness and trapping sediments. However, studies of plant effect on runoff reduction are usually based on the taxonomical characterisation of species and do not refer to effect of aboveground plant functional traits. Plant functional traits approach allows to understand ecosystem processes and quantify services. Traits effect could vary depending on hydrological processes (i.e., discharge) and their aggregation could have a synergetic effect on hydraulic roughness and erosion reduction. In this study, objectives are to i) examine effects of aboveground plant functional traits of herbaceous hedges on hydraulic roughness; ii) test the effects of their aggregation on hydraulic roughness. Seven aboveground functional traits were measured on 14 indigenous plant species from North-West Europe with a high morphological variability (stem and leaf densities; stem diameter, stiffness and dry matter content; leaf area and specific leaf area (SLA)). Those species are perennial herbaceous caespitose or comprising dry biomass in winter. Effects of plant functional traits and their abundance within the community on hydraulic roughness were examined using a runoff simulator at four discharges. Furthermore, the effect of plant functional diversity was analysed using four monospecific (mono-trait) conditions compared to multispecific (multi-traits) conditions. Results showed traits and their abundance influence hydraulic roughness. Indeed, leaf density and leaf area (traits), as well as plant community weighted stem, leaf and shoot areas, stem diameter and SLA are significantly correlated to hydraulic roughness. Moreover, leaf density and leaf area

  14. Understanding Semiotic Technology in University Classrooms: A Social Semiotic Approach to PowerPoint-Assisted Cultural Studies Lectures

    Science.gov (United States)

    Zhao, Sumin; van Leeuwen, Theo

    2014-01-01

    In this paper, we propose a social semiotic approach to studying PowerPoint in university classrooms. Our approach is centred on two premises: (1) PowerPoint is a semiotic technology that can be integrated into the pedagogical discourse of classrooms, and (2) PowerPoint technology encompasses three interrelated dimensions of social semiotic…

  15. Sex Differences in Occupational Choice, Pay, and Worth: A Supply-Side Approach to Understanding the Male-Female Wage Gap.

    Science.gov (United States)

    Hollenbeck, John R.; And Others

    1987-01-01

    Explored utility of adopting supply-side approach to understanding the nature of wage differentials between men and women using job applicants (N=272) as subjects. Results suggested much of the wage gap can be explained by evaluations of outcomes other than pay, and gender-related differences in expectancies, instrumentalities, and valences with…

  16. Implementation of 5E Inquiry Incorporated with Analogy Learning Approach to Enhance Conceptual Understanding of Chemical Reaction Rate for Grade 11 Students

    Science.gov (United States)

    Supasorn, Saksri; Promarak, Vinich

    2015-01-01

    The main purpose of this study was to enhance student understanding of the scientific concepts of chemical reaction rate. Forty-four grade 11 students were the target group. The treatment tools were seven learning plans of 5E inquiry incorporated with an analogy learning approach during 15 hours of class time. In each learning plan, the students…

  17. Adult Learners' Understanding in Learning Islam Using Andragogy Approach: A Study in Kampung Siglap Mosque and Al-Zuhri Higher Learning Institute

    Science.gov (United States)

    Bin Kadir, Mohd Amin; Arifin, Syamsul; Latipun; Fuad, Ahmad Nur

    2016-01-01

    This study describes adult learners' understanding in learning Islam using andragogy approach in which the study was conducted in Kampung Siglap Mosque and Al-Zuhri Higher Learning Institute. Prophet Muhammad (peace be upon him) educate his companions of who are adults from the shackles of "jahiliyyah," spiritual and intellectual…

  18. Sounding the warning bells: the need for a systems approach to understanding behaviour at rail level crossings.

    Science.gov (United States)

    Read, Gemma J M; Salmon, Paul M; Lenné, Michael G

    2013-09-01

    Collisions at rail level crossings are an international safety concern and have been the subject of considerable research effort. Modern human factors practice advocates a systems approach to investigating safety issues in complex systems. This paper describes the results of a structured review of the level crossing literature to determine the extent to which a systems approach has been applied. The measures used to determine if previous research was underpinned by a systems approach were: the type of analysis method utilised, the number of component relationships considered, the number of user groups considered, the number of system levels considered and the type of model described in the research. None of research reviewed was found to be consistent with a systems approach. It is recommended that further research utilise a systems approach to the study of the level crossing system to enable the identification of effective design improvements. Copyright © 2013 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  19. Teaching Teaching & Understanding Understanding

    DEFF Research Database (Denmark)

    2006-01-01

    "Teaching Teaching & Understanding Understanding" is a 19-minute award-winning short-film about teaching at university and higher-level educational institutions. It is based on the "Constructive Alignment" theory developed by Prof. John Biggs. The film delivers a foundation for understanding what...

  20. Cutting through the layers: Alternating perspectives and co-laborative analytic approaches to understanding occupation and its objects

    DEFF Research Database (Denmark)

    Mewes, Julie Sascia; Elliot, Michelle L.; Lee, Kim

    2017-01-01

    In this paper, three qualitative researchers with professional backgrounds in social anthropology, occupational therapy, and occupational science present their methodological and theoretical standpoints and resultant analytical approaches on a single set of ethnographic data – an event occurring ......, such an approach reveals similarities, differences, and complexity that may arise when attempting to locate occupation as the central unit of analysis. The conclusion suggests that cutting through the layers of occupation necessarily provides multiple ontologies....

  1. Theoretical-methodological approach to social imaginary and collective representations: Notes for a sociological understanding of image

    Directory of Open Access Journals (Sweden)

    Jorge Eliécer Martínez Posada

    2009-01-01

    Full Text Available The study of social imaginaries and collective representations from a sociological perspective involves agencying interpretative exercises of image reconstruction, whether mental or pictorial images. Thus, the theoretical path followed in this text points to the understanding of social imaginaries and collective representations, as knowledge tradition socially constructed, and social images, which become historically symbolic points of reference of social action.

  2. Bone marrow transplantation as an established approach for understanding the role of macrophages in atherosclerosis and the metabolic syndrome

    NARCIS (Netherlands)

    Aparicio-Vergara, Marcela; Shiri-Sverdlov, Ronit; Koonen, Debby P. Y.; Hofker, Marten H.

    Purpose of review Bone marrow transplantation (BMT) technology is a firmly established tool for studying atherosclerosis. Only recently it is helping us to understand the inflammatory mechanisms leading to the development of obesity, insulin resistance and type 2 diabetes. Here we review the use of

  3. Using Self-Efficacy Beliefs to Understand How Students in a General Chemistry Course Approach the Exam Process

    Science.gov (United States)

    Willson-Conrad, Angela; Kowalske, Megan Grunert

    2018-01-01

    Retention of students who major in STEM continues to be a major concern for universities. Many students cite poor teaching and disappointing grades as reasons for dropping out of STEM courses. Current college chemistry courses often assess what a student has learned through summative exams. To understand students' experiences of the exam process,…

  4. Lay Understanding of the Causes of Binge Drinking in the United Kingdom and Australia: A Network Diagram Approach

    Science.gov (United States)

    Keatley, David A.; Ferguson, Eamonn; Lonsdale, Adam; Hagger, Martin S.

    2017-01-01

    Binge drinking is associated with deleterious health, social and economic outcomes. This study explored the lay understanding of the causes of binge drinking in members of the general public in the United Kingdom and Australia. Participants in the United Kingdom (N = 133) and Australia (N = 102) completed a network diagram exercise requiring them…

  5. Effect of the 5E Model on Prospective Teachers' Conceptual Understanding of Diffusion and Osmosis: A Mixed Method Approach

    Science.gov (United States)

    Artun, Huseyin; Costu, Bayram

    2013-01-01

    The aim of this study was to explore a group of prospective primary teachers' conceptual understanding of diffusion and osmosis as they implemented a 5E constructivist model and related materials in a science methods course. Fifty prospective primary teachers' ideas were elicited using a pre- and post-test and delayed post-test survey consisting…

  6. Empathy as a Tool for Historical Understanding: An Evaluative Approach of the Ancient Greek Primary History Curriculum

    Science.gov (United States)

    Lazarakou, Elisabeth D.

    2008-01-01

    The present study examines the ancient Greek history curriculum and the corresponding textbook as they are implemented in the fourth grade of primary school in an aim to determine whether and to what extent empathy is recognized as a fundamental tool for historical understanding. A close examination of the curriculum revealed that empathy is not…

  7. Children’s understanding of scientific concepts : Combining a micro-developmental approach with a longitudinal study

    NARCIS (Netherlands)

    van der Steen, Steffie

    2015-01-01

    This paper shows that the social (teacher) and material environment (task) play an active part in children's learning process and cannot be viewed as a separate, outside-based influence on cognitive development. We illustrate this using a longitudinal study on children's understanding of scientific

  8. Soft systems methodology as a potential approach to understanding non-motorised transport users in South Africa

    CSIR Research Space (South Africa)

    Van Rooyen, CE

    2016-07-01

    Full Text Available of this paper is to show the potential of using systems thinking and more particularly Soft Systems Methodology (SSM) as a practical and beneficial instrument that will guide BEPDPs with the ongoing learning process of understanding NMT users and their specific...

  9. Implementation of cooperative learning model type STAD with RME approach to understanding of mathematical concept student state junior high school in Pekanbaru

    Science.gov (United States)

    Nurhayati, Dian Mita; Hartono

    2017-05-01

    This study aims to determine whether there is a difference in the ability of understanding the concept of mathematics between students who use cooperative learning model Student Teams Achievement Division type with Realistic Mathematic Education approach and students who use regular learning in seventh grade SMPN 35 Pekanbaru. This study was quasi experiments with Posttest-only Control Design. The populations in this research were all the seventh grade students in one of state junior high school in Pekanbaru. The samples were a class that is used as the experimental class and one other as the control class. The process of sampling is using purposive sampling technique. Retrieval of data in this study using the documentation, observation sheets, and test. The test use t-test formula to determine whether there is a difference in student's understanding of mathematical concepts. Before the t-test, should be used to test the homogeneity and normality. Based in the analysis of these data with t0 = 2.9 there is a difference in student's understanding of mathematical concepts between experimental and control class. Percentage of students experimental class with score more than 65 was 76.9% and 56.4% of students control class. Thus be concluded, the ability of understanding mathematical concepts students who use the cooperative learning model type STAD with RME approach better than students using the regular learning. So that cooperative learning model type STAD with RME approach is well used in learning process.

  10. A self-determination theory approach to understanding the antecedents of teachers' motivational strategies in physical education.

    Science.gov (United States)

    Taylor, Ian M; Ntoumanis, Nikos; Standage, Martyn

    2008-02-01

    Physical education teachers can influence students' self-determination through the motivational strategies that they use. The current study examined how teachers' reported use of three motivational strategies (providing a meaningful rationale, providing instrumental help and support, and gaining an understanding of the students) were predicted by perceived job pressure, perceptions of student self-determination, the teachers' autonomous orientation, psychological need satisfaction, and self-determination to teach. Structural equation modeling supported a model in which perceived job pressure, perceptions of student self-determination, and teacher autonomous orientation predicted teacher psychological need satisfaction, which, in turn positively influenced teacher self-determination. The last positively predicted the use of all three strategies. Direct positive effects of teachers' psychological need satisfaction on the strategies of gaining an understanding of students and instrumental help and support were also found. In summary, factors that influence teacher motivation may also indirectly affect their motivational strategies toward students.

  11. Is experience on a farm an effective approach to understanding animal products and the management of dairy farming?

    Science.gov (United States)

    Mochizuki, Mariko; Osada, Masahiro; Ishioka, Katsumi; Matsubara, Takako; Momota, Yutaka; Yumoto, Norio; Sako, Toshinori; Kamiya, Shinji; Yoshimura, Itaru

    2014-03-01

    The understanding of animal products and dairy farming is important for the promotion of dairy farming. Thus, to examine the effects of farm experience on the understanding of animal products and the management of dairy farming, the interaction between students and dairy cows was investigated in groups of first-year veterinary nursing students in 2011 and 2012 (n = 201). These students included 181 women and 20 men. Nine items about dairy cows were presented in a questionnaire. The survey was performed before and after praxis on the educational farm attached to the authors' university. After praxis on the farm, increases occurred in the number of positive responses to the items involving the price of milk, dairy farming and the taste of milk. For these items, a significant difference (P animal products and dairy farming. © 2013 Japanese Society of Animal Science.

  12. Where Lies the Risk? An Ecological Approach to Understanding Child Mental Health Risk and Vulnerabilities in Sub-Saharan Africa

    OpenAIRE

    Atilola, Olayinka

    2014-01-01

    Efforts at improving child-health and development initiatives in sub-Saharan Africa had focused on the physical health of children due to the neglect of child and adolescent mental health (CAMH) policy initiatives. A thorough and broad-based understanding of the prevalent child mental-health risk and vulnerability factors is needed to successfully articulate CAMH policies. In this discourse, we present a narrative on the child mental-health risk and vulnerability factors in sub-Saharan Africa...

  13. A Population Genetics-Based and Phylogenetic Approach to Understanding the Evolution of Virulence in the Genus Listeria▿ †

    OpenAIRE

    den Bakker, Henk C.; Bundrant, Brittany N.; Fortes, Esther D.; Orsi, Renato H.; Wiedmann, Martin

    2010-01-01

    The genus Listeria includes (i) the opportunistic pathogens L. monocytogenes and L. ivanovii, (ii) the saprotrophs L. innocua, L. marthii, and L. welshimeri, and (iii) L. seeligeri, an apparent saprotroph that nevertheless typically contains the prfA virulence gene cluster. A novel 10-loci multilocus sequence typing scheme was developed and used to characterize 67 isolates representing six Listeria spp. (excluding L. grayi) in order to (i) provide an improved understanding of the phylogeny an...

  14. A self-determination theory approach to understanding the antecedents of teachers' motivational strategies in physical education

    OpenAIRE

    Taylor, I M; Ntoumanis, N; Standage, M

    2008-01-01

    Physical education teachers can influence students' self-determination through the motivational strategies that they use. The current study examined how teachers' reported use of three motivational strategies (providing a meaningful rationale, providing instrumental help and support, and gaining an understanding of the students) were predicted by perceived job pressure, perceptions of student self-determination, the teachers' autonomous orientation, psychological need satisfaction, and self-d...

  15. An Interdisciplinary Approach to Environmental and Sustainability Education: Developing Geography Students' Understandings of Sustainable Development Using Poetry

    Science.gov (United States)

    Walshe, Nicola

    2017-01-01

    Education for sustainable development (ESD) persists as an important concept within international policy and yet, despite considerable debate, there remains a lack of consensus as to a pedagogy for ESD in schools. This paper presents findings from a study investigating how an interdisciplinary approach to ESD in England developed one class of 16-…

  16. Rethinking Pedagogy for Second-Order Differential Equations: A Simplified Approach to Understanding Well-Posed Problems

    Science.gov (United States)

    Tisdell, Christopher C.

    2017-01-01

    Knowing an equation has a unique solution is important from both a modelling and theoretical point of view. For over 70 years, the approach to learning and teaching "well posedness" of initial value problems (IVPs) for second- and higher-order ordinary differential equations has involved transforming the problem and its analysis to a…

  17. A Cultural Approach to Understanding Professional Experiences of Foreign-Born Faculty in U.S. Educational Leadership Preparation Programs

    Science.gov (United States)

    Khrabrova, Iryna; Sanzo, Karen L.

    2013-01-01

    The purpose of this study was to investigate the professional experiences of foreign-born faculty members serving in U.S. educational leadership preparation programs, utilizing a cultural approach to discern their lived experiences related to professional life. Cultural values were explored as reflected in professional life experiences. The…

  18. Social Change: Toward an Informed and Critical Understanding of Social Justice and the Capabilities Approach in Community Psychology.

    Science.gov (United States)

    Munger, Felix; MacLeod, Tim; Loomis, Colleen

    2016-03-01

    Community psychology has long been concerned with social justice. However, deployments of this term are often vague and undertheorized. To address this weakness in the field's knowledge body we explored John Rawls's theory of social justice and Amartya Sen's economic theory of the capabilities approach and evaluated each for its applicability to community psychology theory, research, and action. Our unpacking of the philosophical and political underpinnings of Rawlsian theory of social justice resulted in identifying characteristics that limit the theory's utility in community psychology, particularly in its implications for action. Our analysis of the capability approach proposed by Amartya Sen revealed a framework that operationalizes social justice in both research and action, and we elaborate on this point. Going beyond benefits to community psychology in adopting the capabilities approach, we posit a bi-directional relationship and discuss how community psychology might also contribute to the capabilities approach. We conclude by suggesting that community psychology could benefit from a manifesto or proclamation that provides a historical background of social justice and critiques the focus on the economic, sociological, and philosophical theories that inform present-day conceptualizations (and lack thereof) of social justice for community psychology. © Society for Community Research and Action 2016.

  19. Understanding the influence of buckwheat bran on wheat dough baking performance: Mechanistic insights from molecular and material science approaches

    NARCIS (Netherlands)

    Zanoletti, M.; Marti, A.; Marengo, M.; Iametti, S.; Pagani, M.A.; Renzetti, S.

    2017-01-01

    A molecular and material science approach is used to describe the influence of coarse and fine buckwheat bran on wheat dough properties and bread textural quality. Focus is given on (i) gluten solvation and structural arrangements in presence of bran as studied by front-face fluorescence; (ii)

  20. (Re)Acting Medicine: Applying Theatre in Order to Develop a Whole-Systems Approach to Understanding the Healing Response

    Science.gov (United States)

    Goldingay, S.; Dieppe, P.; Mangan, M.; Marsden, D.

    2014-01-01

    This critical reflection is based on the belief that creative practitioners should be using their own well-established approaches to trouble dominant paradigms in health and care provision to both form and inform the future of healing provision and well-being creation. It describes work by a transdisciplinary team (drama and medicine) that is…

  1. Understanding Student Approaches to Learning Evolution in the Context of Their Perceptions of the Relationship between Science and Religion

    Science.gov (United States)

    Yasri, Pratchayapong; Mancy, Rebecca

    2014-01-01

    This study investigates a range of positions that learners take on the relationship between science and religion and the potential for these positions to explain student approaches when learning about evolution. A phenomenographic study based on interviews with nine students studying in Christian high schools in Thailand led to the identification…

  2. On the use of the distortion-sensitivity approach in examining the role of linguistic abilities in speech understanding in noise.

    Science.gov (United States)

    Goverts, S Theo; Huysmans, Elke; Kramer, Sophia E; de Groot, Annette M B; Houtgast, Tammo

    2011-12-01

    Researchers have used the distortion-sensitivity approach in the psychoacoustical domain to investigate the role of auditory processing abilities in speech perception in noise (van Schijndel, Houtgast, & Festen, 2001; Goverts & Houtgast, 2010). In this study, the authors examined the potential applicability of the distortion-sensitivity approach for investigating the role of linguistic abilities in speech understanding in noise. The authors applied the distortion-sensitivity approach by measuring the processing of visually presented masked text in a condition with manipulated syntactic, lexical, and semantic cues and while using the Text Reception Threshold (George et al., 2007; Kramer, Zekveld, & Houtgast, 2009; Zekveld, George, Kramer, Goverts, & Houtgast, 2007) method. Two groups that differed in linguistic abilities were studied: 13 native and 10 non-native speakers of Dutch, all typically hearing university students. As expected, the non-native subjects showed substantially reduced performance. The results of the distortion-sensitivity approach yielded differentiated results on the use of specific linguistic cues in the 2 groups. The results show the potential value of the distortion-sensitivity approach in studying the role of linguistic abilities in speech understanding in noise of individuals with hearing impairment.

  3. The role of emotion in decision-making: a cognitive neuroeconomic approach towards understanding sexual risk behavior.

    Science.gov (United States)

    Gutnik, Lily A; Hakimzada, A Forogh; Yoskowitz, Nicole A; Patel, Vimla L

    2006-12-01

    Models of decision-making usually focus on cognitive, situational, and socio-cultural variables in accounting for human performance. However, the emotional component is rarely addressed within these models. This paper reviews evidence for the emotional aspect of decision-making and its role within a new framework of investigation, called neuroeconomics. The new approach aims to build a comprehensive theory of decision-making, through the unification of theories and methods from economics, psychology, and neuroscience. In this paper, we review these integrative research methods and their applications to issues of public health, with illustrative examples from our research on young adults' safe sex practices. This approach promises to be valuable as a comprehensively descriptive and possibly, better predictive model for construction and customization of decision support tools for health professionals and consumers.

  4. Quantitative and qualitative approaches in educational research — problems and examples of controlled understanding through interpretive methods

    Science.gov (United States)

    Neumann, Karl

    1987-06-01

    In the methodological discussion of recent years it has become apparent that many research problems, including problems relating to the theory of educational science, cannot be solved by using quantitative methods. The multifaceted aspects of human behaviour and all its environment-bound subtle nuances, especially the process of education or the development of identity, cannot fully be taken into account within a rigid neopositivist approach. In employing the paradigm of symbolic interactionism as a suitable model for the analysis of processes of education and formation, the research has generally to start out from complex reciprocal social interactions instead of unambigious connections of causes. In analysing several particular methodological problems, the article demonstrates some weaknesses of quantitative approaches and then shows the advantages in and the necessity for using qualitative research tools.

  5. How to define and build an effective cyber threat intelligence capability how to understand, justify and implement a new approach to security

    CERN Document Server

    Dalziel, Henry; Carnall, James

    2014-01-01

    Intelligence-Led Security: How to Understand, Justify and Implement a New Approach to Security is a concise review of the concept of Intelligence-Led Security. Protecting a business, including its information and intellectual property, physical infrastructure, employees, and reputation, has become increasingly difficult. Online threats come from all sides: internal leaks and external adversaries; domestic hacktivists and overseas cybercrime syndicates; targeted threats and mass attacks. And these threats run the gamut from targeted to indiscriminate to entirely accidental. Amo

  6. Mystery behind the match: an undergraduate medical education-graduate medical education collaborative approach to understanding match goals and outcomes.

    Science.gov (United States)

    Nagler, Alisa; Engle, Deborah L; Rudd, Mariah; Chudgar, Saumil M; Weinerth, John L; Kuhn, Catherine M; Buckley, Edward; Grochowski, Colleen O'Connor

    2016-01-01

    There is a paucity of information regarding institutional targets for the number of undergraduate medical education (UME) graduates being matched to graduate medical education (GME) programs at their home institutions. At our institution, the Duke University, the number of UME graduates matched to GME programs declined dramatically in 2011. To better understand why this decline may have happened, we sought to identify perceived quality metrics for UME and GME learners, evaluate trends in match outcomes and educational program characteristics, and explore whether there is an ideal retention rate for UME graduates in their home institutions' GME programs. We analyzed the number of Duke University UME graduates remaining at Duke for GME training over the past 5 years. We collected data to assess for changing characteristics of UME and GME, and performed descriptive analysis of trends over time to investigate the potential impact on match outcomes. A one-sample t -test analysis showed no statistically significant difference in the number of Duke UME graduates who stayed for GME training. For both UME and GME, no significant changes in the characteristics of either program were found. We created a process for monitoring data related to the characteristics or perceived quality of UME and GME programs and developed a shared understanding of what may impact match lists for both UME graduates and GME programs, leaving the Match somewhat less mysterious. While we understand the trend of graduates remaining at their home institutions for GME training, we are uncertain whether setting a goal for retention is reasonable, and so some mystery remains. We believe there is an invaluable opportunity for collaboration between UME and GME stakeholders to facilitate discussion about setting shared institutional goals.

  7. Geo-Sandbox: An Interactive Geoscience Training Tool with Analytics to Better Understand Student Problem Solving Approaches

    Science.gov (United States)

    Butt, N.; Pidlisecky, A.; Ganshorn, H.; Cockett, R.

    2015-12-01

    The software company 3 Point Science has developed three interactive learning programs designed to teach, test and practice visualization skills and geoscience concepts. A study was conducted with 21 geoscience students at the University of Calgary who participated in 2 hour sessions of software interaction and written pre and post-tests. Computer and SMART touch table interfaces were used to analyze user interaction, problem solving methods and visualization skills. By understanding and pinpointing user problem solving methods it is possible to reconstruct viewpoints and thought processes. This could allow us to give personalized feedback in real time, informing the user of problem solving tips and possible misconceptions.

  8. A functional genomics approach to understand the control and regulation of storage protein biosynthesis in barley grain

    DEFF Research Database (Denmark)

    Vincze, É; Hansen, M; Bowra, S

    2008-01-01

    The aim of the study was to obtain an insight into amino acid and storage protein metabolism in the developing barley grain at the molecular level. Our strategy was to analyse the transcriptome of relevant pathways in developing grains of field grown barley using a grain specific microarray assem...... pathways in the barley grain. The study described here could provide a strong complement to existing knowledge assisting further  understanding of seed development and thereby provide a foundation for plant breeding towards storage protein with improved nutritional quality....

  9. Photophysics of sunscreen molecules in the gas phase: a stepwise approach towards understanding and developing next-generation sunscreens

    Science.gov (United States)

    Rodrigues, Natércia D. N.; Staniforth, Michael

    2016-01-01

    The relationship between exposure to ultraviolet (UV) radiation and skin cancer urges the need for extra photoprotection, which is presently provided by widespread commercially available sunscreen lotions. Apart from having a large absorption cross section in the UVA and UVB regions of the electromagnetic spectrum, the chemical absorbers in these photoprotective products should also be able to dissipate the excess energy in a safe way, i.e. without releasing photoproducts or inducing any further, harmful, photochemistry. While sunscreens are tested for both their photoprotective capability and dermatological compatibility, phenomena occurring at the molecular level upon absorption of UV radiation are largely overlooked. To date, there is only a limited amount of information regarding the photochemistry and photophysics of these sunscreen molecules. However, a thorough understanding of the intrinsic mechanisms by which popular sunscreen molecular constituents dissipate excess energy has the potential to aid in the design of more efficient, safer sunscreens. In this review, we explore the potential of using gas-phase frequency- and time-resolved spectroscopies in an effort to better understand the photoinduced excited-state dynamics, or photodynamics, of sunscreen molecules. Complementary computational studies are also briefly discussed. Finally, the future outlook of expanding these gas-phase studies into the solution phase is considered. PMID:27956888

  10. Kinetics of Materials at Extreme Conditions: Understanding the Time Dependent Approach to Equilibrium at MaRIE

    Energy Technology Data Exchange (ETDEWEB)

    Kraus, R. G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Mcnabb, D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kumar, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Eggert, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Borg, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Cerreta, E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dattelbaum, D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Fried, L. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Greeff, C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Stolken, J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-04-21

    The National Nuclear Security Agency has recently recognized that a long-term need exists to establish a stronger scientific basis for the assessment and qualification of materials and manufacturing processes for the nuclear stockpile and other national security applications. These materials may have undergone substantial changes with age, or may represent new materials that are being introduced because of difficulties associated with reusing or recreating materials used in original stockpile components. Also, with advancements in manufacturing methods, the NNSA anticipates opportunities for an enhanced range of control over fabricated components, an enhanced pace of materials development, and enhanced functionality. The development of qualification standards for these new materials will require the ability to understand and control material characteristics that affect both mechanical and dynamic performance. A unique aspect for NNSA is that the performance requirements for materials are often set by system hydrodynamics, and these materials must perform in extreme environments and loading conditions. Thus, the scientific motivation is to understand “Matter-Radiation Interactions in Extremes (MaRIE).”

  11. Application of Cyclone Relative Approach and Ensemble Sensitivity Analysis to Better Understand Extratropical Cyclone Errors in Operational Models and Ensembles

    Science.gov (United States)

    Song, Xinxia

    A cyclone relative approach and an ensemble sensitivity analysis (ESA) were applied to explore some of the possible reasons for extratropical cyclone center mean sea level pressure errors. For the cyclone relative approach, data were extracted within a box region and saved every 6 hours. GEFS (Global Ensemble Forecast System) control member and ensemble members forecast data were utilized in this research. Around the cyclone, errors in fields such as mean sea level pressure and precipitation rapidly increase from day 4 to day 5, and the errors of all fields examined are consistent with the overpredicted and underpredicted cyclones. For example, for an overforecast cyclone, it has more intense PV (potential vorticity) at 320K, a stronger temperature gradient on 925hPa, and greater simulated precipitation than observed, while the underpredicted cyclones have the opposite results. The day 3 precipitation errors and 925 hPa temperature gradient errors are relatively large before the cyclone errors develop, thus suggesting that moisture and latent heat and dry dynamics could contribute to cyclogenesis intensity errors. ESA accompanied with cyclone relative approach implies that moisture may contribute to the cyclogenesis error at an initial stage of cyclone development. There are also hints of upstream errors growing and moving in from ESA cases. AA possible explanation for underpredicted cyclones might be that less moisture on the warm side of cyclones leads to a weaker upper tropospheric latent heat release, and hence a less amplified PV field, and a weaker cyclone. In addition, a weaker temperature gradient at 925 hPa could also cause a weaker cyclone.

  12. Understanding the influence of buckwheat bran on wheat dough baking performance: Mechanistic insights from molecular and material science approaches.

    Science.gov (United States)

    Zanoletti, Miriam; Marti, Alessandra; Marengo, Mauro; Iametti, Stefania; Pagani, M Ambrogina; Renzetti, Stefano

    2017-12-01

    A molecular and material science approach is used to describe the influence of coarse and fine buckwheat bran on wheat dough properties and bread textural quality. Focus is given on (i) gluten solvation and structural arrangements in presence of bran as studied by front-face fluorescence; (ii) thermo-mechanical behavior of dough during heating studied by dynamic mechanical thermal analysis and (iii) texture of bread crumb analyzed in terms of a cellular solid. The thermo-mechanical behavior of dough was found to be largely related to starch phase transitions during heating. The use of thermodynamic approaches to biopolymer melting revealed that key transitions such as the onset of starch gelatinization were function of the interplay of water and bran volume fractions in the dough. Front-face fluorescence studies in wheat dough revealed that gluten solvation and structural arrangements were delayed by increasing bran addition level and reduction in particle size, as indicated by the drastic decrease in the protein surface hydrophobicity index. Variations in gluten structure could be strongly related to dough baking performance, i.e. specific volume. With regards to texture, the approach revealed that crumb texture was controlled by variations in density, moisture and bran volume fractions. Overall, this study elucidates a number of physical mechanisms describing the influence of buckwheat bran addition to dough and bread quality. These mechanisms strongly pointed at the influence of bran on water partitioning among the main polymeric components. In the future, these mechanisms should be investigated with bran material of varying source, composition and structure. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Understand electronics

    CERN Document Server

    Bishop, Owen

    2013-01-01

    Understand Electronics provides a readable introduction to the exciting world of electronics for the student or enthusiast with little previous knowledge. The subject is treated with the minimum of mathematics and the book is extensively illustrated.This is an essential guide for the newcomer to electronics, and replaces the author's best-selling Beginner's Guide to Electronics.The step-by-step approach makes this book ideal for introductory courses such as the Intermediate GNVQ.

  14. Understanding users

    DEFF Research Database (Denmark)

    Johannsen, Carl Gustav Viggo

    2014-01-01

    Segmentation of users can help libraries in the process of understanding user similarities and differences. Segmentation can also form the basis for selecting segments of target users and for developing tailored services for specific target segments. Several approaches and techniques have been...... segmentation project using computer-generated clusters. Compared to traditional marketing texts, this article also tries to identify user segments or images or metaphors by the library profession itself....

  15. Developing a Community-Based Participatory Research Approach to Understanding of the Repeat Use of Psychiatric Emergency Services.

    Science.gov (United States)

    Lincoln, Alisa K; Wallace, Lori; Kaminski, Mary Sharon; Lindeman, Kirstin; Aulier, Louise; Delman, Jonathan

    2016-11-01

    Psychiatric emergency services (PES) remain a critical and under-examined component of the community mental health system. We describe how a unique community-academic partnership came together to examine repeat use of PES through the design and conduct of a qualitative study using a CBPR approach. The goals of the project were to: (1) develop a model of research which promoted the inclusion of people who use mental health services in the research process; and (2) design and conduct a study to examine the repeat use of PES through the inclusion of the perspectives and experiences of people who use these services.

  16. Applying Aspects of the Expert Performance Approach to Better Understand the Structure of Skill and Mechanisms of Skill Acquisition in Video Games.

    Science.gov (United States)

    Boot, Walter R; Sumner, Anna; Towne, Tyler J; Rodriguez, Paola; Anders Ericsson, K

    2017-04-01

    Video games are ideal platforms for the study of skill acquisition for a variety of reasons. However, our understanding of the development of skill and the cognitive representations that support skilled performance can be limited by a focus on game scores. We present an alternative approach to the study of skill acquisition in video games based on the tools of the Expert Performance Approach. Our investigation was motivated by a detailed analysis of the behaviors responsible for the superior performance of one of the highest scoring players of the video game Space Fortress (Towne, Boot, & Ericsson, ). This analysis revealed how certain behaviors contributed to his exceptional performance. In this study, we recruited a participant for a similar training regimen, but we collected concurrent and retrospective verbal protocol data throughout training. Protocol analysis revealed insights into strategies, errors, mental representations, and shifting game priorities. We argue that these insights into the developing representations that guided skilled performance could only easily have been derived from the tools of the Expert Performance Approach. We propose that the described approach could be applied to understand performance and skill acquisition in many different video games (and other short- to medium-term skill acquisition paradigms) and help reveal mechanisms of transfer from gameplay to other measures of laboratory and real-world performance. Copyright © 2016 Cognitive Science Society, Inc.

  17. Understanding racial HIV/STI disparities in black and white men who have sex with men: a multilevel approach.

    Directory of Open Access Journals (Sweden)

    Patrick S Sullivan

    Full Text Available The reasons for black/white disparities in HIV epidemics among men who have sex with men have puzzled researchers for decades. Understanding reasons for these disparities requires looking beyond individual-level behavioral risk to a more comprehensive framework.From July 2010-December 2012, 803 men (454 black, 349 white were recruited through venue-based and online sampling; consenting men were provided HIV and STI testing, completed a behavioral survey and a sex partner inventory, and provided place of residence for geocoding. HIV prevalence was higher among black (43% versus white (13% MSM (prevalence ratio (PR 3.3, 95% confidence interval (CI: 2.5-4.4. Among HIV-positive men, the median CD4 count was significantly lower for black (490 cells/µL than white (577 cells/µL MSM; there was no difference in the HIV RNA viral load by race. Black men were younger, more likely to be bisexual and unemployed, had less educational attainment, and reported fewer male sex partners, fewer unprotected anal sex partners, and less non-injection drug use. Black MSM were significantly more likely than white MSM to have rectal chlamydia and gonorrhea, were more likely to have racially concordant partnerships, more likely to have casual (one-time partners, and less likely to discuss serostatus with partners. The census tracts where black MSM lived had higher rates of poverty and unemployment, and lower median income. They also had lower proportions of male-male households, lower male to female sex ratios, and lower HIV diagnosis rates.Among black and white MSM in Atlanta, disparities in HIV and STI prevalence by race are comparable to those observed nationally. We identified differences between black and white MSM at the individual, dyadic/sexual network, and community levels. The reasons for black/white disparities in HIV prevalence in Atlanta are complex, and will likely require a multilevel framework to understand comprehensively.

  18. Understanding African American women's decisions to buy and eat dark green leafy vegetables: an application of the reasoned action approach.

    Science.gov (United States)

    Sheats, Jylana L; Middlestadt, Susan E; Ona, Fernando F; Juarez, Paul D; Kolbe, Lloyd J

    2013-01-01

    Examine intentions to buy and eat dark green leafy vegetables (DGLV). Cross-sectional survey assessing demographics, behavior, intention, and Reasoned Action Approach constructs (attitude, perceived norm, self-efficacy). Marion County, Indiana. African American women responsible for buying and preparing household food. Reasoned Action Approach constructs explaining intentions to buy and eat DGLV. Summary statistics, Pearson correlations, and multiple regression analyses. Among participants (n = 410, mean age = 43 y), 76% and 80%, respectively, reported buying and eating DGLV in the past week. Mean consumption was 1.5 cups in the past 3 days. Intentions to buy (r = 0.20, P eat (r = 0.23, P eat DGLV. Attitude (β = .63) and self-efficacy (β = .24) related to buying and attitude (β = .60) and self-efficacy (β = .23) related to eating DGLV explained significant amounts of variance in intentions to buy and eat more DGLV. Perceived norm was unrelated to either intention to buy or eat DGLV. Interventions designed for this population of women should aim to improve DGLV-related attitudes and self-efficacy. Copyright © 2013 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

  19. The Climate Change-Road Safety-Economy Nexus: A System Dynamics Approach to Understanding Complex Interdependencies

    Directory of Open Access Journals (Sweden)

    Mehdi Alirezaei

    2017-01-01

    Full Text Available Road accidents have the highest externality costs to society and to the economy, even when compared to the externality damages associated with air emissions and oil dependency. Road safety is one of the most complicated topics, which involves many interdependencies, and so, a sufficiently thorough analysis of roadway safety will require a novel system-based approach in which the associated feedback relationships and causal effects are given appropriate consideration. The factors affecting accident frequency and severity are highly dependent on economic parameters, environmental factors and weather conditions. In this study, we try to use a system dynamics modeling approach to model the climate change-road safety-economy nexus, thereby investigating the complex interactions among these important areas by tracking how they affect each other over time. For this purpose, five sub-models are developed to model each aspect of the overall nexus and to interact with each other to simulate the overall system. As a result, this comprehensive model can provide a platform for policy makers to test the effectiveness of different policy scenarios to reduce the negative consequences of traffic accidents and improve road safety.

  20. A systems approach to understanding the identification and treatment of sport-related concussion in community rugby union.

    Science.gov (United States)

    Clacy, Amanda; Goode, Natassia; Sharman, Rachael; Lovell, Geoff P; Salmon, Paul

    2017-07-04

    The aim of the present study was to utilise a systems thinking approach to explore the perceived responsibilities for identifying and treating concussion held by different actors across the community rugby system (e.g., players, coaches, parents, medics, referees, and management), as well as their role-specific concussion management strategies. A systems approach was taken to assess what different stakeholders within rugby systems perceive their roles to be regarding concussion identification and treatment. Through an online survey, 118 members of the amateur (community) rugby union system were asked about their role-specific concussion management responsibilities and strategies. Respondents included players, parents, medics, coaches, club managers, administrators, and volunteers. The majority of respondents indicated that they were able to identify the symptoms of rugby-related concussion, however, only medics stated their responsibility to use formal concussion assessments (e.g., SCAT2). A smaller number of the respondents indicated that they were involved in treating concussion within their current role/s (majority of which were medics). This study illustrated that the current challenges in the identification and treatment of rugby-related concussion in community sport may be due to role/responsibility confusion and possible overreliance on field-side medics. These findings offer insight into the possible limitations of the current concussion management guidelines and may offer empirically based direction for future revisions. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Advancing current approaches to disease management evaluation: capitalizing on heterogeneity to understand what works and for whom.

    Science.gov (United States)

    Elissen, Arianne M J; Adams, John L; Spreeuwenberg, Marieke; Duimel-Peeters, Inge G P; Spreeuwenberg, Cor; Linden, Ariel; Vrijhoef, Hubertus J M

    2013-03-14

    Evaluating large-scale disease management interventions implemented in actual health care settings is a complex undertaking for which universally accepted methods do not exist. Fundamental issues, such as a lack of control patients and limited generalizability, hamper the use of the 'gold-standard' randomized controlled trial, while methodological shortcomings restrict the value of observational designs. Advancing methods for disease management evaluation in practice is pivotal to learn more about the impact of population-wide approaches. Methods must account for the presence of heterogeneity in effects, which necessitates a more granular assessment of outcomes. This paper introduces multilevel regression methods as valuable techniques to evaluate 'real-world' disease management approaches in a manner that produces meaningful findings for everyday practice. In a worked example, these methods are applied to retrospectively gathered routine health care data covering a cohort of 105,056 diabetes patients who receive disease management for type 2 diabetes mellitus in the Netherlands. Multivariable, multilevel regression models are fitted to identify trends in clinical outcomes and correct for differences in characteristics of patients (age, disease duration, health status, diabetes complications, smoking status) and the intervention (measurement frequency and range, length of follow-up). After a median one year follow-up, the Dutch disease management approach was associated with small average improvements in systolic blood pressure and low-density lipoprotein, while a slight deterioration occurred in glycated hemoglobin. Differential findings suggest that patients with poorly controlled diabetes tend to benefit most from disease management in terms of improved clinical measures. Additionally, a greater measurement frequency was associated with better outcomes, while longer length of follow-up was accompanied by less positive results. Despite concerted efforts to adjust

  2. Ways of Walking: Understanding Walking's Implications for the Design of Handheld Technology Via a Humanistic Ethnographic Approach

    Directory of Open Access Journals (Sweden)

    Parisa Eslambolchilar

    2016-01-01

    Full Text Available It seems logical to argue that mobile computing technologies are intended for use "on-the-go." However, on closer inspection, the use of mobile technologies pose a number of challenges for users who are mobile, particularly moving around on foot. In engaging with such mobile technologies and their envisaged development, we argue that interaction designers must increasingly consider a multitude of perspectives that relate to walking in order to frame design problems appropriately. In this paper, we consider a number of perspectives on walking, and we discuss how these may inspire the design of mobile technologies. Drawing on insights from non-representational theory, we develop a partial vocabulary with which to engage with qualities of pedestrian mobility, and we outline how taking more mindful approaches to walking may enrich and inform the design space of handheld technologies

  3. Using cognitive concept mapping to understand what health care means to the elderly: an illustrative approach for planning and marketing.

    Science.gov (United States)

    Shewchuk, Richard; O'Connor, Stephen J

    2002-01-01

    This article describes a process that can be used for eliciting and systematically organizing perceptions held by key stakeholders. An example using a limited sample of older Medicare recipients is developed to illustrate how this approach can be used. Internally, a nominal group technique (NGT) meeting was conducted to identify an array of health care issues that were perceived as important by this group. These perceptions were then used as stimuli to develop an unforced card sort task. Data from the card sorts were analyzed using multidimensional scaling and hierarchical cluster analysis to demonstrate how qualitative input of participants can be organized. The results of these analyses are described to illustrate an example of an interpretive framework that might be used when seeking input from relevant constituents. Suggestions for how this process might be extended to health care planning/marketing efforts are provided.

  4. e-Human Grid Ecology - understanding and approaching the inverse tragedy of the commons in the e-Grid society.

    Science.gov (United States)

    Knoch, Tobias A; Baumgärtner, Volkmar; de Zeeuw, Luc V; Grosveld, Frank G; Egger, Kurt

    2009-01-01

    With ever-new technologies emerging also the amount of information to be stored and processed is growing exponentially and is believed to be always at the limit. In contrast, however, huge resources are available in the IT sector alike e.g. the renewable energy sector, which are often even not at all used. This under-usage bares any rational especially in the IT sector where e.g. virtualisation and grid approaches could be fast implemented due to the great technical and fast turnover opportunities. Here, we describe this obvious paradox for the first time as the Inverse Tragedy of the Commons, in contrast to the Classical Tragedy of the Commons where resources are overexploited. From this perspective the grid IT sector attempting to share resources for better efficiency, reveals two challenges leading to the heart of the paradox: i) From a macro perspective all grid infrastructures involve not only mere technical solutions but also dominantly all of the autopoietic social sub-systems ranging from religion to policy. ii) On the micro level the individual players and their psychology and risk behaviour are of major importance for acting within the macro autopoietic framework. Thus, the challenges of grid implementation are similar to those of e.g. climate protection. This is well described by the classic Human Ecology triangle and our extension to a rectangle: invironment-individual-society-environment. Extension of this classical interdisciplinary field of basic and applied research to an e-Human Grid Ecology rational, allows the Inverse Tragedy of the Commons of the grid sector to be understood and approached better and implies obvious guidelines in the day-to-day management for grid and other (networked) resources, which is of importance for many fields with similar paradoxes as in (e-)society.

  5. A transdisciplinary approach to understanding the causes of wicked problems such as the violent conflict in Rwanda

    Directory of Open Access Journals (Sweden)

    Andreas Velthuizen

    2012-07-01

    Full Text Available The paper is presented against a background of many wicked problems that confront us in the world today such as violent crime, conflict that emanates from political power seeking, contests for scarce resources, the increasing reaction all over the world to the deterioration of socio-economic conditions and the devastation caused by natural disasters. This article will argue that the challenge of violent conflict requires an innovative approach to research and problem solving and proposes a research methodology that follows a transdisciplinary approach. The argument is informed by field research during 2006 on the management of knowledge in the Great Lakes region of Africa, including research on how knowledge on the 1994 genocide in Rwanda is managed. The paper will make recommendations on how transdisciplinary research is required to determine the causes of violent conflict in an African context and how practitioners and academics should engage in transdisciplinarity. It was found that trans- disciplinary research is required to gain better insight into the causes of violent conflict in an African context. It requires from the researcher to recognise the many levels of reality that has to be integrated towards a synthesis to reveal new insights into the causes of violent conflict, including recognising the existence of a normative-spiritual realm that informs the epistemology of Africa. It furthermore requires a methodology that allows us to break out of the stifling constraints of systems thinking and linear processes into the inner space at the juncture where disciplines meet (the diversity of African communities. Keywords: Africa, conflict, Rwanda, crime, genocide, violence, transdisciplinary Disciplines: politics, education, law, epistemology, sociology, theology, management science

  6. Implementation of health promotion programmes in schools: an approach to understand the influence of contextual factors on the process?

    Science.gov (United States)

    Darlington, Emily Joan; Violon, Nolwenn; Jourdan, Didier

    2018-01-22

    Implementing complex and multi-level public health programmes is challenging in school settings. Discrepancies between expected and actual programme outcomes are often reported. Such discrepancies are due to complex interactions between contextual factors. Contextual factors relate to the setting, the community, in which implementation occurs, the stakeholders involved, and the characteristics of the programme itself. This work uses realist evaluation to understand how contextual factors influence the implementation process, to result in variable programme outcomes. This study focuses on identifying contextual factors, pinpointing combinations of contextual factors, and understanding interactions and effects of such factors and combinations on programme outcomes on different levels of the implementation process. Schools which had participated in a school-based health promotion programme between 2012 and 2015 were included. Two sets of qualitative data were collected: semi-structured interviews with school staff and programme coordinators; and written documents about the actions implemented in a selection of four schools. Quantitative data included 1553 questionnaires targeting pupils aged 8 to 11 in 14 schools to describe the different school contexts. The comparison between what was expected from the programme (programme theory) and the outcomes identified in the field data, showed that some of the mechanisms expected to support the implementation of the programme, did not operate as anticipated (e.g. inclusion of training, initiation by decision-maker). Key factors which influenced the implementation process included, amongst other factors, the mode of introduction of the programme, home/school relationship, leadership of the management team, and the level of delegated power. Five types of interactions between contextual factors were put forward: enabling, hindering, neutral, counterbalancing and moderating effects. Recurrent combinations of factors were

  7. The emergence of the State. A holistic approach to understand the origin, the role and challenges of public power

    Directory of Open Access Journals (Sweden)

    Luis I. Gordillo Pérez

    2017-01-01

    Full Text Available The term "State" is often used to identify a political phenomenon that emerged in Europe since the collapse of feudalism with the fundamental characteristics of territoriality, centralization, sovereignty, differentiation and institutionalization. This concept leads to limitations that result from the application of a methodology that is incomplete for a comprehensive understanding of the State, as it does not differentiate within the so-called States, the various existing types and political and social consequences derived from each of these types. This paper advocates the use of the methodology used by Pierre Birnbaum to analyze the State as a historical fact and social which is a creation from own social practices of a time and a specific space, in relation to a particular culture and with a particular historical trajectory. To this end, this article deals, first, with the sociological-historical theory on the origin of the State along with the presentation of their methodology and analysis of the relationship of capitalism, social structure and culture with the State (paragraphs 2 and 3 ; secondly, this work focuses on the advantages of the methodology proposed by Birnbaum to analyze the State while original creation, highlighting the division Strong State / Weak State proposed by the author (4 and 5; and, finally, it raises the challenges facing the State today (paragraphs 6 and 7.

  8. Applying a pattern-centered approach to understanding how attachment, gender beliefs, and homosociality shape college men's sociosexuality.

    Science.gov (United States)

    Calzo, Jerel P

    2014-01-01

    Although early research and the popular press have characterized college men as universal beneficiaries of uncommitted sex, emerging research notes considerable variability in men's sociosexuality (i.e., uncommitted sexual beliefs, desires, and behaviors). This study examined how diversity in sociosexuality is tied to the ways in which attachment orientations, conformity to masculinity norms, and homosocial engagement (i.e., nonromantic same-sex bonds) are organized across individuals. Latent profile analysis of 495 college males (ages 17 to 25, 62% White, 83.5% heterosexual) detected five subgroups: Fully Unrestricted (10% of sample; high on sociosexuality and conformity to masculinity norms); Cognitively Unrestricted (36%; comparable to Fully Unrestricteds but low on sociosexual behavior), Fully Restricted (30%; opposite on all constructs when compared to Fully Unrestricteds); Avoidant (16%; similar to Fully Restricteds but with greater attachment avoidance); and Discrepant (8%; above average on sociosexual behavior but discordant within and across constructs). There were notable demographic, personality, and behavioral differences among the subgroups (e.g., nearly 50% of the Discrepants self-identified as sexual minorities; Fully Restricteds were the most religious; Avoidants were the most shy). Findings indicate that college men's sociosexuality is highly nuanced and suggest the need for additional work to understand how attachment, masculinity norms, and homosociality shape men's sexual relationships.

  9. Proteomics approach to understand reduced clearance of mycobacteria and high viral titers during HIV-mycobacteria co-infection.

    Science.gov (United States)

    Ganji, Rakesh; Dhali, Snigdha; Rizvi, Arshad; Sankati, Swetha; Vemula, Mani Harika; Mahajan, Gaurang; Rapole, Srikanth; Banerjee, Sharmistha

    2016-03-01

    Environmental mycobacteria, highly prevalent in natural and artificial (including chlorinated municipal water) niches, are emerging as new threat to human health, especially to HIV-infected population. These seemingly harmless non-pathogenic mycobacteria, which are otherwise cleared, establish as opportunistic infections adding to HIV-associated complications. Although immune-evading strategies of pathogenic mycobacteria are known, the mechanisms underlying the early events by which opportunistic mycobacteria establish infection in macrophages and influencing HIV infection are unclear. Proteomics of phagosome-enriched fractions from Mycobacterium bovis Bacillus Calmette-Guérin (BCG) mono-infected and HIV-M. bovis BCG co-infected THP-1 cells by LC-MALDI-MS/MS revealed differential distribution of 260 proteins. Validation of the proteomics data showed that HIV co-infection helped the survival of non-pathogenic mycobacteria by obstructing phagosome maturation, promoting lipid biogenesis and increasing intracellular ATP equivalents. In turn, mycobacterial co-infection up-regulated purinergic receptors in macrophages that are known to support HIV entry, explaining increased viral titers during co-infection. The mutualism was reconfirmed using clinically relevant opportunistic mycobacteria, Mycobacterium avium, Mycobacterium kansasii and Mycobacterium phlei that exhibited increased survival during co-infection, together with increase in HIV titers. Additionally, the catalogued proteins in the study provide new leads that will significantly add to the understanding of the biology of opportunistic mycobacteria and HIV coalition. © 2015 John Wiley & Sons Ltd.

  10. A population genetics-based and phylogenetic approach to understanding the evolution of virulence in the genus Listeria.

    Science.gov (United States)

    den Bakker, Henk C; Bundrant, Brittany N; Fortes, Esther D; Orsi, Renato H; Wiedmann, Martin

    2010-09-01

    The genus Listeria includes (i) the opportunistic pathogens L. monocytogenes and L. ivanovii, (ii) the saprotrophs L. innocua, L. marthii, and L. welshimeri, and (iii) L. seeligeri, an apparent saprotroph that nevertheless typically contains the prfA virulence gene cluster. A novel 10-loci multilocus sequence typing scheme was developed and used to characterize 67 isolates representing six Listeria spp. (excluding L. grayi) in order to (i) provide an improved understanding of the phylogeny and evolution of the genus Listeria and (ii) use Listeria as a model to study the evolution of pathogenicity in opportunistic environmental pathogens. Phylogenetic analyses identified six well-supported Listeria species that group into two main subdivisions, with each subdivision containing strains with and without the prfA virulence gene cluster. Stochastic character mapping and phylogenetic analysis of hly, a gene in the prfA cluster, suggest that the common ancestor of the genus Listeria contained the prfA virulence gene cluster and that this cluster was lost at least five times during the evolution of Listeria, yielding multiple distinct saprotrophic clades. L. welshimeri, which appears to represent the most ancient clade that arose from an ancestor with a prfA cluster deletion, shows a considerably lower average sequence divergence than other Listeria species, suggesting a population bottleneck and a putatively different ecology than other saprotrophic Listeria species. Overall, our data suggest that, for some pathogens, loss of virulence genes may represent a selective advantage, possibly by facilitating adaptation to a specific ecological niche.

  11. Understanding barriers to fruit and vegetable intake in the Australian Longitudinal Study of Indigenous Children: a mixed-methods approach.

    Science.gov (United States)

    Thurber, Katherine Ann; Banwell, Cathy; Neeman, Teresa; Dobbins, Timothy; Pescud, Melanie; Lovett, Raymond; Banks, Emily

    2017-04-01

    To identify barriers to fruit and vegetable intake for Indigenous Australian children and quantify factors related to these barriers, to help understand why children do not meet recommendations for fruit and vegetable intake. We examined factors related to carer-reported barriers using multilevel Poisson models (robust variance); a key informant focus group guided our interpretation of findings. Eleven diverse sites across Australia. Australian Indigenous children and their carers (N 1230) participating in the Longitudinal Study of Indigenous Children. Almost half (45 %; n 555/1230) of carers reported barriers to their children's fruit and vegetable intake. Dislike of fruit and vegetables was the most common barrier, reported by 32·9 % of carers; however, we identified few factors associated with dislike. Carers were more than ten times less likely to report barriers to accessing fruit and vegetables if they lived large cities v. very remote areas. Within urban and inner regional areas, child and carer well-being, financial security, suitable housing and community cohesion promoted access to fruit and vegetables. In this national Indigenous Australian sample, almost half of carers faced barriers to providing their children with a healthy diet. Both remote/outer regional carers and disadvantaged urban/inner regional carers faced problems accessing fruit and vegetables for their children. Where vegetables were accessible, children's dislike was a substantial barrier. Nutrition promotion must address the broader family, community, environmental and cultural contexts that impact nutrition, and should draw on the strengths of Indigenous families and communities.

  12. Toward Understanding Dynamics in Shifting Biomes: An Individual Based Modeling Approach to Characterizing Drought and Mortality in Central Western Canada

    Science.gov (United States)

    Armstrong, A. H.; Foster, A.; Rogers, B. M.; Hogg, T.; Michaelian, M.; Shuman, J. K.; Shugart, H. H., Jr.; Goetz, S. J.

    2017-12-01

    The Arctic-Boreal zone is known be warming at an accelerated rate relative to other biomes. Persistent warming has already affected the high northern latitudes, altering vegetation productivity, carbon sequestration, and many other ecosystem processes and services. The central-western Canadian boreal forests and aspen parkland are experiencing a decade long drought, and rainfall has been identified as a key factor controlling the location of the boundary between forest and prairie in this region. Shifting biome with related greening and browning trends are readily measureable with remote sensing, but the dynamics that create and result from them are not well understood. In this study, we use the University of Virginia Forest Model Enhanced (UVAFME), an individual-based forest model, to simulate the changes that are occurring across the southern boreal and parkland forests of west-central Canada. We present a parameterization of UVAFME for western central Canadian forests, validated with CIPHA data (Climate Change Impacts on the Productivity and Health of Aspen), and improved mortality. In order to gain a fine-scale understanding of how climate change and specifically drought will continue to affect the forests of this region, we simulated forest conditions following CMIP5 climate scenarios. UVAFME predictions were compared with statistical models and satellite observations of productivity across the landscape. Changes in forest cover, forest type, aboveground biomass, and mortality and recruitment dynamics are presented, highlighting the high vulnerability of this region to vegetation transitions associated with future droughts.

  13. Scanning electron microscopy-based approach to understand the mechanism underlying the adhesion of dengue viruses on ceramic hydroxyapatite columns.

    Directory of Open Access Journals (Sweden)

    Maiko Saito

    Full Text Available Although ceramic hydroxyapatite (HAp chromatography has been used as an alternative method ultracentrifugation for the production of vaccines, the mechanism of virus separation is still obscure. In order to begin to understand the mechanisms of virus separation, HAp surfaces were observed by scanning electron microscopy after chromatography with dengue viruses. When these processes were performed without elution and with a 10-207 mM sodium phosphate buffer gradient elution, dengue viruses that were adsorbed to HAp were disproportionately located in the columns. However, when eluted with a 10-600 mM sodium phosphate buffer gradient, few viruses were observed on the HAp surface. After incubating the dengue viruses that were adsorbed on HAp beads at 37°C and 2°C, the sphericity of the dengue viruses were reduced with an increase in incubation temperature. These results suggested that dengue virus was adsorbed to the HAp surface by electronic interactions and could be eluted by high-salt concentration buffers, which are commonly used in protein purification. Furthermore, virus fusion was thought to occur with increasing temperature, which implied that virus-HAp adhesion was similar to virus-cell adhesion.

  14. An Exploratory Sequential Mixed Methods Approach to Understanding Researchers’ Data Management Practices at UVM: Findings from the Qualitative Phase

    Directory of Open Access Journals (Sweden)

    Elizabeth A. Berman

    2017-03-01

    Full Text Available This is the first in a series of articles reporting on a study of researcher data management practices and data services at the University of Vermont. The objective of this article is to report on the first qualitative phase of an exploratory sequential mixed methods research design focused on researcher data management practices and related institutional research data services. The aim of this study is to understand data management behaviors of faculty at the University of Vermont (UVM, a higher-research activity Research University, in order to guide the development of campus research data management services. The population of study was all faculty who received National Science Foundation (NSF grants between 2011 and 2014 who were required to submit a data management plan (DMP; qualitative data was collected in two forms: (1 semi-structured interviews and (2 document analysis of data management plans. From a population of 47 researchers, six were included in the interview sample, representing a broad range of disciplines and NSF Directorates, and 35 data management plans were analyzed. Three major themes were identified through triangulation of qualitative data sources: data management activities, including data dissemination and data sharing; institutional research support and infrastructure barriers; and perceptions of data management plans and attitudes towards data management planning. The themes articulated in this article will be used to design a survey for the second quantitative phase of the study, which will aim to more broadly generalize data management activities at UVM across all disciplines.

  15. A Population Genetics-Based and Phylogenetic Approach to Understanding the Evolution of Virulence in the Genus Listeria▿ †

    Science.gov (United States)

    den Bakker, Henk C.; Bundrant, Brittany N.; Fortes, Esther D.; Orsi, Renato H.; Wiedmann, Martin

    2010-01-01

    The genus Listeria includes (i) the opportunistic pathogens L. monocytogenes and L. ivanovii, (ii) the saprotrophs L. innocua, L. marthii, and L. welshimeri, and (iii) L. seeligeri, an apparent saprotroph that nevertheless typically contains the prfA virulence gene cluster. A novel 10-loci multilocus sequence typing scheme was developed and used to characterize 67 isolates representing six Listeria spp. (excluding L. grayi) in order to (i) provide an improved understanding of the phylogeny and evolution of the genus Listeria and (ii) use Listeria as a model to study the evolution of pathogenicity in opportunistic environmental pathogens. Phylogenetic analyses identified six well-supported Listeria species that group into two main subdivisions, with each subdivision containing strains with and without the prfA virulence gene cluster. Stochastic character mapping and phylogenetic analysis of hly, a gene in the prfA cluster, suggest that the common ancestor of the genus Listeria contained the prfA virulence gene cluster and that this cluster was lost at least five times during the evolution of Listeria, yielding multiple distinct saprotrophic clades. L. welshimeri, which appears to represent the most ancient clade that arose from an ancestor with a prfA cluster deletion, shows a considerably lower average sequence divergence than other Listeria species, suggesting a population bottleneck and a putatively different ecology than other saprotrophic Listeria species. Overall, our data suggest that, for some pathogens, loss of virulence genes may represent a selective advantage, possibly by facilitating adaptation to a specific ecological niche. PMID:20656873

  16. The cytotoxicity of polycationic iron oxide nanoparticles: Common endpoint assays and alternative approaches for improved understanding of cellular response mechanism

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    Hoskins Clare

    2012-04-01

    Full Text Available Abstract Background Iron oxide magnetic nanoparticles (MNP's have an increasing number of biomedical applications. As such in vitro characterisation is essential to ensure the bio-safety of these particles. Little is known on the cellular interaction or effect on membrane integrity upon exposure to these MNPs. Here we synthesised Fe3O4 and surface coated with poly(ethylenimine (PEI and poly(ethylene glycol (PEG to achieve particles of varying surface positive charges and used them as model MNP's to evaluate the relative utility and limitations of cellular assays commonly applied for nanotoxicity assessment. An alternative approach, atomic force microscopy (AFM, was explored for the analysis of membrane structure and cell morphology upon interacting with the MNPs. The particles were tested in vitro on human SH-SY5Y, MCF-7 and U937 cell lines for reactive oxygen species (ROS production and lipid peroxidation (LPO, LDH leakage and their overall cytotoxic effect. These results were compared with AFM topography imaging carried out on fixed cell lines. Results Successful particle synthesis and coating were characterised using FTIR, PCS, TEM and ICP. The particle size from TEM was 30 nm (−16.9 mV which increased to 40 nm (+55.6 mV upon coating with PEI and subsequently 50 nm (+31.2 mV with PEG coating. Both particles showed excellent stability not only at neutral pH but also in acidic environment of pH 4.6 in the presence of sodium citrate. The higher surface charge MNP-PEI resulted in increased cytotoxic effect and ROS production on all cell lines compared with the MNP-PEI-PEG. In general the effect on the cell membrane integrity was observed only in SH-SY5Y and MCF-7 cells by MNP-PEI determined by LDH leakage and LPO production. AFM topography images showed consistently that both the highly charged MNP-PEI and the less charged MNP-PEI-PEG caused cell morphology changes possibly due to membrane disruption and cytoskeleton remodelling. Conclusions

  17. Understanding the impacts of allocation approaches during process-based life cycle assessment of water treatment chemicals.

    Science.gov (United States)

    Alvarez-Gaitan, Juan P; Peters, Gregory M; Short, Michael D; Schulz, Matthias; Moore, Stephen

    2014-01-01

    to the changes in commodity prices encountered during the study period, with standard deviations less than 6% for all chlor-alkali-produced chemicals reported here. Overall outcomes from the study demonstrate the potential variability in LCA results according to the allocation approach taken and emphasize the need for a consensus approach to water sector LCAs. © 2013 SETAC.

  18. Network approach to understanding the organization of and the consequence of targeted leader removal on an end-oriented task.

    Science.gov (United States)

    Annagiri, Sumana; Kolay, Swetashree; Paul, Bishwarup; Sona, Chandan

    2017-06-01

    Relocation is an important event in the lives of several social insects whereby all colony members have to be transferred to a new nest when conditions in the old nest become unfavorable. In the current study, network tools were used to examine the organization of this goal-oriented task in the Indian queenless ant Diacamma indicum which relocate their colonies by means of tandem running. Individual ants were used as nodes and tandem runs as directed edges to construct unweighted networks. Network parameters were characterized in control relocations (CRs) and in relocations where the node with the highest outdegree, that is, the Maximum tandem leader (Max TL) was experimentally removed. These were then compared to 1) randomized networks, 2) simulated networks in which Max TL was removed, and 3) simulated networks with removal of a random leader. Not only was there complete recovery of the task, but the manner in which it was organized when Max TL was removed was comparable to CRs. The results obtained from our empirical study were significantly different from the results predicted by simulations of leader removal. At an individual level, the Max TL had a significantly higher outdegree than expected by chance alone and in her absence the substitute Max TL did comparable work. In addition, the position of the Max TL in the pathway of information flow was conserved in control and experimentally manipulated conditions. Understanding the organization of this critical event as more than the sum of individual interactions using network parameters allows us to appreciate the dynamic response of groups to perturbations.

  19. An ecological public health approach to understanding the relationships between sustainable urban environments, public health and social equity.

    Science.gov (United States)

    Bentley, Michael

    2014-09-01

    The environmental determinants of public health and social equity present many challenges to a sustainable urbanism-climate change, water shortages and oil dependency to name a few. There are many pathways from urban environments to human health. Numerous links have been described but some underlying mechanisms behind these relationships are less understood. Combining theory and methods is a way of understanding and explaining how the underlying structures of urban environments relate to public health and social equity. This paper proposes a model for an ecological public health, which can be used to explore these relationships. Four principles of an ecological public health-conviviality, equity, sustainability and global responsibility-are used to derive theoretical concepts that can inform ecological public health thinking, which, among other things, provides a way of exploring the underlying mechanisms that link urban environments to public health and social equity. Theories of more-than-human agency inform ways of living together (conviviality) in urban areas. Political ecology links the equity concerns about environmental and social justice. Resilience thinking offers a better way of coming to grips with sustainability. Integrating ecological ethics into public health considers the global consequences of local urban living and thus attends to global responsibility. This way of looking at the relationships between urban environments, public health and social equity answers the call to craft an ecological public health for the twenty-first century by re-imagining public health in a way that acknowledges humans as part of the ecosystem, not separate from it, though not central to it. © The Author (2013). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  20. An Exploratory Sequential Mixed Methods Approach to Understanding Researchers’ Data Management Practices at UVM: Findings from the Quantitative Phase

    Directory of Open Access Journals (Sweden)

    Elizabeth A. Berman

    2017-03-01

    Full Text Available This is the second in a series of articles reporting on a study of researcher data management practices and data services at the University of Vermont. This article reports on the second quantitative phase of an exploratory sequential mixed methods research design focused on researcher data management practices and related institutional support and services. The study aims to understand data management activities and challenges of faculty at the University of Vermont (UVM, a higher research activity Research University, in order to develop appropriate research data services (RDS. Data was collected via a survey, built on themes from the initial qualitative data analysis from the first phase of this study. The survey was distributed to a nonrandom census sample of full-time UVM faculty and researchers (P=1,190; from this population, a total of 319 participants completed the survey for a 26.8% response rate. The survey collected information on five dimensions of data management: data management activities; data management plans; data management challenges; data management support; and attitudes and behaviors towards data management planning. Frequencies, cross tabulations, and chi-square tests of independence were calculated using demographic variables including gender, rank, college, and discipline. Results from the analysis provide a snapshot of research data management activities at UVM, including types of data collected, use of metadata, short- and long-term storage of data, and data sharing practices. The survey identified key challenges to data management, including data description (metadata and sharing data with others; this latter challenge is particular impacted by confidentiality issues and lack of time, personnel, and infrastructure to make data available. Faculty also provided insight to RDS that they think UVM should support, as well as RDS they were personally interested in. Data from this study will be integrated with data from the

  1. Coordination of the cortisol and testosterone responses: A dual axis approach to understanding the response to social status threats.

    Science.gov (United States)

    Turan, Bulent; Tackett, Jennifer L; Lechtreck, Maria T; Browning, Wesley R

    2015-12-01

    facilitate performance. These findings have implications for developing a dual axis understanding of physiological responses during social threats and competition and their function. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Johne's disease in the eyes of Irish cattle farmers: A qualitative narrative research approach to understanding implications for disease management.

    Science.gov (United States)

    McAloon, Conor G; Macken-Walsh, Áine; Moran, Lisa; Whyte, Paul; More, Simon J; O'Grady, Luke; Doherty, Michael L

    2017-06-01

    Bovine Johne's Disease (JD) is a disease characterised by chronic granulomatous enteritis which manifests clinically as a protein-losing enteropathy causing diarrhoea, hypoproteinaemia, emaciation and, eventually death. Some research exists to suggest that the aetiologic pathogen Mycobacterium avium subspecies paratuberculosis may pose a zoonotic risk. Nationally coordinated control programmes have been introduced in many of the major milk producing countries across the world. However, JD is challenging to control in infected herds owing to limitations of diagnostic tests and the long incubation period of the disease. Internationally, research increasingly recognises that improved understanding of farmers' subjective views and behaviours may inform and enhance disease management strategies and support the identification and implementation of best practice at farm level. The aim of this study was to use qualitative research methods to explore the values and knowledges of farmers relative to the control of JD at farm level. The Biographical Narrative Interpretive Method (BNIM) was used to generate data from both infected and presumed uninfected farms in Ireland. Qualitative analysis revealed that cultural and social capital informed farmers' decisions on whether to introduce control and preventive measures. Cultural capital refers to the pride and esteem farmers associate with particular objects and actions whereas social capital is the value that farmers associate with social relationships with others. On-farm controls were often evaluated by farmers as impractical and were frequently at odds with farmers' knowledge of calf management. Knowledge from farmers of infected herds did not disseminate among peer farmers. Owners of herds believed to be uninfected expressed a view that controls and preventive measures were not worthy of adoption until there was clear evidence of JD in the herd. These findings highlight important barriers and potential aids to prevention and

  3. An Integrative Approach to Understand the Climatic-Hydrological Process: A Case Study of Yarkand River, Northwest China

    Directory of Open Access Journals (Sweden)

    Jianhua Xu

    2013-01-01

    Full Text Available Taking the Yarkand River as an example, this paper conducted an integrative approach combining the Durbin-Watson statistic test (DWST, multiple linear regression (MLR, wavelet analysis (WA, coefficient of determination (CD, and Akaike information criterion (AIC to analyze the climatic-hydrological process of inland river, Northwest China from a multitime scale perspective. The main findings are as follows. (1 The hydrologic and climatic variables, that is, annual runoff (AR, annual average temperature, (AAT and annual precipitation (AP, are stochastic and, no significant autocorrelation. (2 The variation patterns of runoff, temperature, and precipitation were scale dependent in time. AR, AAT, and AP basically present linear trends at 16-year and 32-year scales, but they show nonlinear fluctuations at 2-year and 4-year scales. (3 The relationship between AR with AAT and AP was simulated by the multiple linear regression equation (MLRE based on wavelet analysis at each time scale. But the simulated effect at a larger time scale is better than that at a smaller time scale.

  4. Manipulatives-Based Laboratory for Majors Biology – a Hands-On Approach to Understanding Respiration and Photosynthesis

    Directory of Open Access Journals (Sweden)

    Sarah M. Boomer

    2011-09-01

    Full Text Available The first course in our year-long introductory series for Biology majors encompasses four learning units: biological molecules and cells, metabolism, genetics, and evolution. Of these, the metabolism unit, which includes respiration and photosynthesis, has shown the lowest student exam scores, least interest, and lowest laboratory ratings. Consequently, we hypothesized that modeling metabolic processes in the laboratory would improve student content learning during this course unit. Specifically, we developed manipulatives-based laboratory exercises that combined paper cutouts, movable blocks, and large diagrams of the cell. In particular, our novel use of connecting LEGO blocks allowed students to move model electrons and phosphates between molecules and within defined spaces of the cell. We assessed student learning using both formal (content indicators and attitude surveys and informal (the identification of misconceptions or discussions with students approaches. On the metabolism unit content exam, student performance improved by 46% over pretest scores and by the end of the course, the majority of students rated metabolism as their most-improved (43% and favorite (33% subject as compared with other unit topics. The majority of students rated manipulatives-based labs as very helpful, as compared to non-manipulatives-based labs. In this report, we will demonstrate that students made learning gains across all content areas, but most notably in the unit that covered respiration and photosynthesis.

  5. Elucidating stress proteins in rice (Oryza sativa L.) genotype under elevated temperature: a proteomic approach to understand heat stress response.

    Science.gov (United States)

    Kumar, Narendra; Suyal, Deep Chandra; Sharma, Ishwar Prakash; Verma, Amit; Singh, Hukum

    2017-07-01

    Rice is one of the widely consumed staple foods among the world's human population. Its production is adversely affected by high temperature and is more pronounced at flowering stage. Elucidating elevated temperature stress-related proteins as well as associated mechanisms is inevitable for improving heat tolerance in rice. In the present study, a proteomic analysis of heat-sensitive rice genotype, IET 21405 was conducted. Two-dimensional electrophoresis (2-DE) and MALDI-TOF/MS-based proteomics approaches revealed a total of 73 protein spots in rice leaf. The protein profiles clearly indicated variations in protein expression between the control and heat treated rice genotypes. Functional assessment of 73 expressed proteins revealed several mechanisms thought to be involved in high temperature including their putative role in metabolism, energy, protein synthesis, protein transport/storage, etc. Besides these, some proteins are expected to involve in photosynthesis, tricarboxylic acid (TCA) cycle, glycolysis and other proteins for energy production. The proteins identified in the present study provide a strong basis to elucidate gene function of these proteins and to explain further the molecular mechanisms underlying the adaptation of rice to high temperature stress.

  6. Integrating community assembly and biodiversity to better understand ecosystem function: the Community Assembly and the Functioning of Ecosystems (CAFE) approach.

    Science.gov (United States)

    Bannar-Martin, Katherine H; Kremer, Colin T; Ernest, S K Morgan; Leibold, Mathew A; Auge, Harald; Chase, Jonathan; Declerck, Steven A J; Eisenhauer, Nico; Harpole, Stanley; Hillebrand, Helmut; Isbell, Forest; Koffel, Thomas; Larsen, Stefano; Narwani, Anita; Petermann, Jana S; Roscher, Christiane; Cabral, Juliano Sarmento; Supp, Sarah R

    2018-02-01

    The research of a generation of ecologists was catalysed by the recognition that the number and identity of species in communities influences the functioning of ecosystems. The relationship between biodiversity and ecosystem functioning (BEF) is most often examined by controlling species richness and randomising community composition. In natural systems, biodiversity changes are often part of a bigger community assembly dynamic. Therefore, focusing on community assembly and the functioning of ecosystems (CAFE), by integrating both species richness and composition through species gains, losses and changes in abundance, will better reveal how community changes affect ecosystem function. We synthesise the BEF and CAFE perspectives using an ecological application of the Price equation, which partitions the contributions of richness and composition to function. Using empirical examples, we show how the CAFE approach reveals important contributions of composition to function. These examples show how changes in species richness and composition driven by environmental perturbations can work in concert or antagonistically to influence ecosystem function. Considering how communities change in an integrative fashion, rather than focusing on one axis of community structure at a time, will improve our ability to anticipate and predict changes in ecosystem function. © 2017 The Authors. Ecology Letters published by CNRS and John Wiley & Sons Ltd.

  7. A Quantile Regression Approach to Understanding the Relations Among Morphological Awareness, Vocabulary, and Reading Comprehension in Adult Basic Education Students.

    Science.gov (United States)

    Tighe, Elizabeth L; Schatschneider, Christopher

    2016-07-01

    The purpose of this study was to investigate the joint and unique contributions of morphological awareness and vocabulary knowledge at five reading comprehension levels in adult basic education (ABE) students. We introduce the statistical technique of multiple quantile regression, which enabled us to assess the predictive utility of morphological awareness and vocabulary knowledge at multiple points (quantiles) along the continuous distribution of reading comprehension. To demonstrate the efficacy of our multiple quantile regression analysis, we compared and contrasted our results with a traditional multiple regression analytic approach. Our results indicated that morphological awareness and vocabulary knowledge accounted for a large portion of the variance (82%-95%) in reading comprehension skills across all quantiles. Morphological awareness exhibited the greatest unique predictive ability at lower levels of reading comprehension whereas vocabulary knowledge exhibited the greatest unique predictive ability at higher levels of reading comprehension. These results indicate the utility of using multiple quantile regression to assess trajectories of component skills across multiple levels of reading comprehension. The implications of our findings for ABE programs are discussed. © Hammill Institute on Disabilities 2014.

  8. Theoretical and Methodological Approaches to Understanding Human Migration Patterns and their Utility in Forensic Human Identification Cases

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    Anastasia Holobinko

    2012-06-01

    Full Text Available Human migration patterns are of interest to scientists representing many fields. Theories have been posited to explain modern human evolutionary expansion, the diversity of human culture, and the motivational factors underlying an individual or group decision to migrate. Although the research question and subsequent approach may vary between disciplines, one thread is ubiquitous throughout most migration studies: why do humans migrate and what is the result of such an event? While the determination of individual attributes such as age, sex, and ancestry is often integral to migration studies, the positive identification of human remains is usually irrelevant. However, the positive identification of a deceased is paramount to a forensic investigation in which human remains have been recovered and must be identified. What role, if any, might the study of human movement patterns play in the interpretation of evidence associated with unidentified human remains? Due to increasing global mobility in the world's populations, it is not inconceivable that an individual might die far away from his or her home. If positive identification cannot immediately be made, investigators may consider various theories as to how or why a deceased ended up in a particular geographic location. While scientific evidence influences the direction of forensic investigations, qualitative evaluation can be an important component of evidence interpretation. This review explores several modern human migration theories and the methodologies utilized to identify evidence of human migratory movement before addressing the practical application of migration theory to forensic cases requiring the identification of human remains.

  9. Know Your Client and Know Your Team: A Complexity Inspired Approach to Understanding Safe Transitions in Care

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    Deborah Tregunno

    2013-01-01

    Full Text Available Background. Transitions in care are one of the most important and challenging client safety issues in healthcare. This project was undertaken to gain insight into the practice setting realities for nurses and other health care providers as they manage increasingly complex care transitions across multiple settings. Methods. The Appreciative Inquiry approach was used to guide interviews with sixty-six healthcare providers from a variety of practice settings. Data was collected on participants’ experience of exceptional care transitions and opportunities for improving care transitions. Results. Nurses and other healthcare providers need to know three things to ensure safe care transitions: (1 know your client; (2 know your team on both sides of the transfer; and (3 know the resources your client needs and how to get them. Three themes describe successful care transitions, including flexible structures; independence and teamwork; and client and provider focus. Conclusion. Nurses often operate at the margins of acceptable performance, and flexibility with regulation and standards is often required in complex sociotechnical work like care transitions. Priority needs to be given to creating conditions where nurses and other healthcare providers are free to creatively engage and respond in ways that will optimize safe care transitions.

  10. A qualitative approach to understand antiretroviral therapy (ART) adherence for refugees living in Nakivale Refugee Settlement in Uganda.

    Science.gov (United States)

    O'Laughlin, Kelli N; Rouhani, Shada A; Kasozi, Julius; Greenwald, Kelsy E; Perkons, Nicholas R; Faustin, Zikama M; Bassett, Ingrid V; Ware, Norma C

    2018-01-01

    Refugees living with HIV in sub-Saharan Africa suffer unique hardships that may increase their vulnerability to interruptions in antiretroviral therapy (ART). To investigate refugees' experiences adhering to ART, we conducted inperson interviews with refugees on ART ( n  = 73) and HIV clinic staff ( n  = 4) in Nakivale Refugee Settlement in southwest Uganda from March to July 2011. Three analysts used a conventional content analysis approach to evaluate these data. Refugees described profound motivation to adhere to ART and employed adherence strategies to facilitate success despite the austere setting. However, refugees spoke of specific hardships living in Nakivale that served as barriers to ART adherence, including difficulty accessing clinic when ill, food insecurity, drug stockouts, and violence and unrest in the settlement. For some refugees, need for ART inextricably linked them to the HIV clinic and prevented them from transitioning permanently away from the settlement. By learning about refugees' experiences we can design informed interventions to enhance ART adherence, thus minimizing morbidity and mortality, preventing transmission of HIV, and supporting refugees' abilities to move freely toward repatriation, resettlement or integration in their host country.

  11. Understanding effects of microstructural inhomogeneity on creep response – New approaches to improve the creep resistance in magnesium alloys

    Directory of Open Access Journals (Sweden)

    Yuanding Huang

    2014-06-01

    Full Text Available Previous investigations indicate that the creep resistance of magnesium alloys is proportional to the stability of precipitated intermetallic phases at grain boundaries. These stable intermetallic phases were considered to be effective to suppress the deformation by grain boundary sliding, leading to the improvement of creep properties. Based on this point, adding the alloying elements to form the stable intermetallics with high melting point became a popular way to develop the new creep resistant magnesium alloys. The present investigation, however, shows that the creep properties of binary Mg–Sn alloy are still poor even though the addition of Sn possibly results in the precipitation of thermal stable Mg2Sn at grain boundaries. That means other possible mechanisms function to affect the creep response. It is finally found that the poor creep resistance is attributed to the segregation of Sn at dendritic and grain boundaries. Based on this observation, new approaches to improve the creep resistance are suggested for magnesium alloys because most currently magnesium alloys have the commonality with the Mg–Sn alloys.

  12. Temporal Genetic Modifications after Controlled Cortical Impact—Understanding Traumatic Brain Injury through a Systematic Network Approach

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    Yung-Hao Wong

    2016-02-01

    Full Text Available Traumatic brain injury (TBI is a primary injury caused by external physical force and also a secondary injury caused by biological processes such as metabolic, cellular, and other molecular events that eventually lead to brain cell death, tissue and nerve damage, and atrophy. It is a common disease process (as opposed to an event that causes disabilities and high death rates. In order to treat all the repercussions of this injury, treatment becomes increasingly complex and difficult throughout the evolution of a TBI. Using high-throughput microarray data, we developed a systems biology approach to explore potential molecular mechanisms at four time points post-TBI (4, 8, 24, and 72 h, using a controlled cortical impact (CCI model. We identified 27, 50, 48, and 59 significant proteins as network biomarkers at these four time points, respectively. We present their network structures to illustrate the protein–protein interactions (PPIs. We also identified UBC (Ubiquitin C, SUMO1, CDKN1A (cyclindependent kinase inhibitor 1A, and MYC as the core network biomarkers at the four time points, respectively. Using the functional analytical tool MetaCore™, we explored regulatory mechanisms and biological processes and conducted a statistical analysis of the four networks. The analytical results support some recent findings regarding TBI and provide additional guidance and directions for future research.

  13. Multidisciplinary approaches to understanding auditory hallucinations in schizophrenia and nonschizophrenia populations: the International Consortium on Hallucination Research.

    Science.gov (United States)

    Waters, Flavie

    2012-06-01

    This special theme issue of Schizophrenia Bulletin presents a series of related articles focusing on auditory hallucinations, prepared by members of the International Consortium on Hallucination Research [InCoHR] working groups. The InCoHR is a large collaborative framework that serves as a platform for researchers to meet and collaborate on multidisciplinary projects relating to auditory hallucinations [AH] and discuss methodological issues facing transdiagnostic research. Laroi et al. observe the similarities in characteristic features of AHs in different clinical and nonclinical groups, but they also note that differences exist, reflecting the contribution of disease-related process. Waters et al. use findings of shared cognitive impairments across different diagnostic groups with AHs to propose a novel theoretical cognitive framework. Allen et al. describe that the neurobiological substrates of AHs include neural systems involved in language processing, as well as sensory and nonsensory brain regions and that studies are increasingly using fine-grain analysis of patients' characteristics in analyzing neuroimaging data. Ford et al. discuss different neurophysiological approaches and describes hallucination-related alterations in activity in temporal and frontal regions of the brain and particularly in auditory cortical areas. Finally, Sommer et al. review different treatment options for AHs in schizophrenia and other disorders, including pharmacological treatment, cognitive-behavioral therapy [CBT] and acceptance and commitment therapy [ACT], transcranial magnetic stimulation [TMS], and electroconvulsive therapy [ECT]. These related publications describe the current substance and direction of research on AHs across different diagnostic groups.

  14. A Quantile Regression Approach to Understanding the Relations Between Morphological Awareness, Vocabulary, and Reading Comprehension in Adult Basic Education Students

    Science.gov (United States)

    Tighe, Elizabeth L.; Schatschneider, Christopher

    2015-01-01

    The purpose of this study was to investigate the joint and unique contributions of morphological awareness and vocabulary knowledge at five reading comprehension levels in Adult Basic Education (ABE) students. We introduce the statistical technique of multiple quantile regression, which enabled us to assess the predictive utility of morphological awareness and vocabulary knowledge at multiple points (quantiles) along the continuous distribution of reading comprehension. To demonstrate the efficacy of our multiple quantile regression analysis, we compared and contrasted our results with a traditional multiple regression analytic approach. Our results indicated that morphological awareness and vocabulary knowledge accounted for a large portion of the variance (82-95%) in reading comprehension skills across all quantiles. Morphological awareness exhibited the greatest unique predictive ability at lower levels of reading comprehension whereas vocabulary knowledge exhibited the greatest unique predictive ability at higher levels of reading comprehension. These results indicate the utility of using multiple quantile regression to assess trajectories of component skills across multiple levels of reading comprehension. The implications of our findings for ABE programs are discussed. PMID:25351773

  15. Application of community phylogenetic approaches to understand gene expression: differential exploration of venom gene space in predatory marine gastropods.

    Science.gov (United States)

    Chang, Dan; Duda, Thomas F

    2014-06-05

    Predatory marine gastropods of the genus Conus exhibit substantial variation in venom composition both within and among species. Apart from mechanisms associated with extensive turnover of gene families and rapid evolution of genes that encode venom components ('conotoxins'), the evolution of distinct conotoxin expression patterns is an additional source of variation that may drive interspecific differences in the utilization of species' 'venom gene space'. To determine the evolution of expression patterns of venom genes of Conus species, we evaluated the expression of A-superfamily conotoxin genes of a set of closely related Conus species by comparing recovered transcripts of A-superfamily genes that were previously identified from the genomes of these species. We modified community phylogenetics approaches to incorporate phylogenetic history and disparity of genes and their expression profiles to determine patterns of venom gene space utilization. Less than half of the A-superfamily gene repertoire of these species is expressed, and only a few orthologous genes are coexpressed among species. Species exhibit substantially distinct expression strategies, with some expressing sets of closely related loci ('under-dispersed' expression of available genes) while others express sets of more disparate genes ('over-dispersed' expression). In addition, expressed genes show higher dN/dS values than either unexpressed or ancestral genes; this implies that expression exposes genes to selection and facilitates rapid evolution of these genes. Few recent lineage-specific gene duplicates are expressed simultaneously, suggesting that expression divergence among redundant gene copies may be established shortly after gene duplication. Our study demonstrates that venom gene space is explored differentially by Conus species, a process that effectively permits the independent and rapid evolution of venoms in these species.

  16. Understanding and changing human behaviour--antibiotic mainstreaming as an approach to facilitate modification of provider and consumer behaviour.

    Science.gov (United States)

    Stålsby Lundborg, Cecilia; Tamhankar, Ashok J

    2014-05-01

    This paper addresses: 1) Situations where human behaviour is involved in relation to antibiotics, focusing on providers and consumers; 2) Theories about human behaviour and factors influencing behaviour in relation to antibiotics; 3) How behaviour in relation to antibiotics can change; and, 4) Antibiotic mainstreaming as an approach to facilitate changes in human behaviour as regards antibiotics. Influencing human behaviour in relation to antibiotics is a complex process which includes factors like knowledge, attitudes, social norms, socio-economic conditions, peer pressure, experiences, and bio-physical and socio-behavioural environment. Further, key concepts are often perceived in different ways by different individuals. While designing and implementing projects or programmes for behavioural change with respect to antibiotics for professionals or consumers it is helpful to consider theories or models of behaviour change, e.g. the 'stages of change model', including pre-contemplation, contemplation, preparation, action, and maintenance. People in different stages of change are susceptible to different behaviour modification strategies. Application of marketing principles to 'global good', so-called 'social marketing', to improve 'welfare of the individual and society' is gaining increased attention in public health. In conclusion, just providing correct knowledge is not sufficient although it is a pre-requisite for behaviour modification in the desired direction. We can never change the behaviour of any other human, but we can facilitate for others to change their own behaviour. One possibility is to implement 'antibiotic mainstreaming' as a potentially effective way for behaviour modification, i.e. to address consequences for maintaining effective antibiotics in all activities and decisions in society.

  17. Understanding determinants of socioeconomic inequality in mental health in Iran's capital, Tehran: a concentration index decomposition approach.

    Science.gov (United States)

    Morasae, Esmaeil Khedmati; Forouzan, Ameneh Setareh; Majdzadeh, Reza; Asadi-Lari, Mohsen; Noorbala, Ahmad Ali; Hosseinpoor, Ahmad Reza

    2012-03-26

    Mental health is of special importance regarding socioeconomic inequalities in health. On the one hand, mental health status mediates the relationship between economic inequality and health; on the other hand, mental health as an "end state" is affected by social factors and socioeconomic inequality. In spite of this, in examining socioeconomic inequalities in health, mental health has attracted less attention than physical health. As a first attempt in Iran, the objectives of this paper were to measure socioeconomic inequality in mental health, and then to untangle and quantify the contributions of potential determinants of mental health to the measured socioeconomic inequality. In a cross-sectional observational study, mental health data were taken from an Urban Health Equity Assessment and Response Tool (Urban HEART) survey, conducted on 22 300 Tehran households in 2007 and covering people aged 15 and above. Principal component analysis was used to measure the economic status of households. As a measure of socioeconomic inequality, a concentration index of mental health was applied and decomposed into its determinants. The overall concentration index of mental health in Tehran was -0.0673 (95% CI = -0.070 - -0.057). Decomposition of the concentration index revealed that economic status made the largest contribution (44.7%) to socioeconomic inequality in mental health. Educational status (13.4%), age group (13.1%), district of residence (12.5%) and employment status (6.5%) also proved further important contributors to the inequality. Socioeconomic inequalities exist in mental health status in Iran's capital, Tehran. Since the root of this avoidable inequality is in sectors outside the health system, a holistic mental health policy approach which includes social and economic determinants should be adopted to redress the inequitable distribution of mental health.

  18. Understanding north-western Mediterranean climate variability: a multi-proxy and multi-sequence approach based on wavelet analysis.

    Science.gov (United States)

    Azuara, Julien; Lebreton, Vincent; Jalali, Bassem; Sicre, Marie-Alexandrine; Sabatier, Pierre; Dezileau, Laurent; Peyron, Odile; Frigola, Jaime; Combourieu-Nebout, Nathalie

    2017-04-01

    Forcings and physical mechanisms underlying Holocene climate variability still remain poorly understood. Comparison of different paleoclimatic reconstructions using spectral analysis allows to investigate their common periodicities and helps to understand the causes of past climate changes. Wavelet analysis applied on several proxy time series from the Atlantic domain already revealed the first key-issues on the origin of Holocene climate variability. However the differences in duration, resolution and variance between the time-series are important issues for comparing paleoclimatic sequences in the frequency domain. This work compiles 7 paleoclimatic proxy records from 4 time-series from the north-western Mediterranean all ranging from 7000 to 1000 yrs cal BP: -pollen and clay mineral contents from the lagoonal sediment core PB06 recovered in southern France, -Sea Surface Temperatures (SST) derived from alkenones, concentration of terrestrial alkanes and their average chain length (ACL) from core KSGC-31_GolHo-1B recovered in the Gulf of Lion inner-shelf, - δ18O record from speleothems recovered in the Asiul Cave in north-western Spain, -grain size record from the deep basin sediment drift core MD99-2343 north of Minorca island. A comparison of their frequency content is proposed using wavelet analysis and cluster analysis of wavelet power spectra. Common cyclicities are assessed using cross-wavelet analysis. In addition, a new algorithm is used in order to propagate the age model errors within wavelet power spectra. Results are consistents with a non-stationnary Holocene climate variability. The Halstatt cycles (2000-2500 years) depicted in many proxies (ACL, errestrial alkanes and SSTs) demonstrate solar activity influence in the north-western Mediterranean climate. Cluster analysis shows that pollen and ACL proxies, both indicating changes in aridity, are clearly distinct from other proxies and share significant common periodicities around 1000 and 600 years

  19. Investigation of the fluid flow dynamic parameters for Newtonian and non-Newtonian materials: an approach to understanding the fluid flow-like structures within fault zones

    Science.gov (United States)

    Tanaka, H.; Shiomi, Y.; Ma, K.-F.

    2017-11-01

    To understand the fault zone fluid flow-like structure, namely the ductile deformation structure, often observed in the geological field (e.g., Ramsay and Huber The techniques of modern structure geology, vol. 1: strain analysis, Academia Press, London, 1983; Hobbs and Ord Structure geology: the mechanics of deforming metamorphic rocks, Vol. I: principles, Elsevier, Amsterdam, 2015), we applied a theoretical approach to estimate the rate of deformation, the shear stress and the time to form a streak-line pattern in the boundary layer of viscous fluids. We model the dynamics of streak lines in laminar boundary layers for Newtonian and pseudoplastic fluids and compare the results to those obtained via laboratory experiments. The structure of deformed streak lines obtained using our model is consistent with experimental observations, indicating that our model is appropriate for understanding the shear rate, flow time and shear stress based on the profile of deformed streak lines in the boundary layer in Newtonian and pseudoplastic viscous materials. This study improves our understanding of the transportation processes in fluids and of the transformation processes in fluid-like materials. Further application of this model could facilitate understanding the shear stress and time history of the fluid flow-like structure of fault zones observed in the field.[Figure not available: see fulltext.

  20. Deposition of boron on fuel rod surface under sub-cooled boiling conditions-An approach toward understanding AOA occurrence

    International Nuclear Information System (INIS)

    Uchida, Shunsuke; Asakura, Yamato; Suzuki, Hiroaki

    2011-01-01

    ; (iii) one of the most promising approaches to evaluate its accumulation on the fuel rod surface during plant operation was the MED model calculation; and (iv) control of nickel concentration in the primary coolant resulted in decreased nickel oxide deposition and then mitigation of AOA occurrence due to decreasing average residence time of boron on the fuel rod surface.

  1. The role of biological sciences in understanding the genesis and a new therapeutic approach to Alzheimer’s disease

    Directory of Open Access Journals (Sweden)

    Eugenia Tęgowska

    2011-01-01

    Full Text Available The paper contrasts the historical view on causal factors in Alzheimer’s disease (AD with the modern concept of the symptoms’ origin. Biological sciences dealing with cell structure and physiology enabled comprehension of the role of mitochondrial defects in the processes of formation of neurofibrillary tangles and β-amyloid, which in turn gives hope for developing a new, more effective therapeutic strategy for AD. It has been established that although mitochondria constantly generate free radicals, from which they are protected by their own defensive systems, in some situations these systems become deregulated, which leads to free radical-based mitochondrial defects. This causes an energetic deficit in neurons and a further increase in the free radical pool. As a result, due to compensation processes, formation of tangles and/or acceleration of β-amyloid production takes place. The nature of these processes is initially a protective one, due to their anti-oxidative action, but as the amount of the formations increases, their beneficial effect wanes. They become a storage place for substances enhancing free radical processes, which makes them toxic themselves. It is such an approach to the primary causal factor for AD which lies at the roots of the new view on AD therapy, suggesting the use of methylene blue-based drugs, laser or intranasally applied insulin. A necessary condition, however, for these methods’ effectiveness is definitely an earlier diagnosis of the disease. Although there are numerous diagnostic methods for AD, their low specificity and high price, often accompanied by a considerable level of patient discomfort, make them unsuitable for early, prodromal screening. In this matter a promising method may be provided using an olfactory test, which is an inexpensive and non-invasive method and thus suitable for screening, although as a test of low specificity, it should be combined with other methods. Introducing new methods

  2. Filling Knowledge Gaps in Biological Networks: integrating global approaches to understand H2 metabolism in Chlamydomonas reinhardtii - Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Posewitz, Matthew C

    2011-06-30

    The green alga Chlamydomonas reinhardtii (Chlamydomonas) has numerous genes encoding enzymes that function in fermentative pathways. Among these genes, are the [FeFe]-hydrogenases, pyruvate formate lyase, pyruvate ferredoxin oxidoreductase, acetate kinase, and phosphotransacetylase. We have systematically undertaken a series of targeted mutagenesis approaches to disrupt each of these key genes and omics techniques to characterize alterations in metabolic flux. Funds from DE-FG02-07ER64423 were specifically leveraged to generate mutants with disruptions in the genes encoding the [FeFe]-hydrogenases HYDA1 and HYDA2, pyruvate formate lyase (PFL1), and in bifunctional alcohol/aldehyde alcohol dehydrogenase (ADH1). Additionally funds were used to conduct global transcript profiling experiments of wildtype Chlamydomonas cells, as well as of the hydEF-1 mutant, which is unable to make H2 due to a lesion in the [FeFe]-hydrogenase biosynthetic pathway. In the wildtype cells, formate, acetate and ethanol are the dominant fermentation products with traces of CO2 and H2 also being produced. In the hydEF-1 mutant, succinate production is increased to offset the loss of protons as a terminal electron acceptor. In the pfl-1 mutant, lactate offsets the loss of formate production, and in the adh1-1 mutant glycerol is made instead of ethanol. To further probe the system, we generated a double mutant (pfl1-1 adh1) that is unable to synthesize both formate and ethanol. This strain, like the pfl1 mutants, secreted lactate, but also exhibited a significant increase in the levels of extracellular glycerol, acetate, and intracellular reduced sugars, and a decline in dark, fermentative H2 production. Whereas wild-type Chlamydomonas fermentation primarily produces formate and ethanol, the double mutant performs a complete rerouting of the glycolytic carbon to lactate and glycerol. Lastly, transcriptome data have been analysed for both the wildtype and hydEF-1, that correlate with our

  3. Understanding the relationship between brain and upper limb function in children with unilateral motor impairments: A multimodal approach.

    Science.gov (United States)

    Weinstein, Maya; Green, Dido; Rudisch, Julian; Zielinski, Ingar M; Benthem-Muñiz, Marta; Jongsma, Marijtje L A; McClelland, Verity; Steenbergen, Bert; Shiran, Shelly; Ben Bashat, Dafna; Barker, Gareth J

    2018-01-01

    ) and a mixed (n = 1) connectivity pattern; again without clear association with MMs. No differences were found between children with and without MMs in lesion scores, motor fMRI laterality indices, CST diffusivity values, and upper limb function. In the genu, midbody, and splenium of the CC, higher fractional anisotropy values were found in children with MMs compared to children without MMs. The EEG data indicated a stronger mu-restoration above the contralateral hemisphere in 6/8 children and above the ipsilateral hemisphere in 2/8 children. The current results demonstrate benefits from the use of different modalities when studying upper-limb function in children with CP; not least to accommodate to the variations in tolerance and feasibility of implementation of the differing methods. These exposed multiple individual brain-reorganization patterns corresponding to different functional motor abilities. Additional research is warranted to understand the transactional influences of early brain injury, neuroplasticity and developmental and environmental factors on hand function in order to develop targeted interventions. Copyright © 2017 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

  4. A unified approach to understanding conductivity enhancement in nanoparticle-filled solid polymer electrolytes for lithium-ion batteries

    Science.gov (United States)

    Fullerton Shirey, Susan K.

    2009-12-01

    the conductive (PEO)6:LiClO4 remnants, allowing them to persist long enough for conduction to occur. We suggest that pure PEO and (PEO)6:LiClO4 form alternating layers extending away from the nanoparticle surface - consistent with the structure expected at a eutectic. This could provide a conductive pathway for lithium ions, accounting for the improved conductivity at this concentration. Above the eutectic temperature, the layers can fluctuate and rearrange easily, and are likely stabilized by the nanoparticle surface. These results suggests a new mechanism for increased lithium-ion transport in nanoparticle-filled solid polymer electrolytes. Water boosts the conductivity in both filled and unfilled samples. This is attributed to the fact that water increases the segmental motion of the polymer, and therefore the ion mobility. When nanoparticles are added, the conductivity boost is unaffected at the 8:1 concentration, whereas nanoparticles decrease the conductivity boost at a concentration of 10:1. While we do not know for certain, it is possible that the 8:1 sample undergoes phase-separation into regions rich and poor in Li+/H2O, with nanoparticles located in the Li+/H2O-poor regions. Conduction will occur in the Li+/H2O-rich regions, meaning that nanoparticles will have no influence on the conductivity-boost with water. In contrast, it is likely that the 10:1 sample will not phase separate, owing to that fact that it is at the eutectic concentration where the energies of all phases are equivalent. The results of this study suggest that structure could play an important role for improving ionic conductivity in solid polymer electrolytes, despite the fact that ion transport through structure is often dismissed in favor of transport through purely amorphous regions. We suggest that nanoparticles improve conductivity by stabilizing and aligning the conductive (PEO) 6:LiClO4 remnants. Understanding transport through the (PEO) 6:LiX structure is important for designing a

  5. The importance of economic, social and cultural capital in understanding health inequalities: using a Bourdieu-based approach in research on physical and mental health perceptions.

    Science.gov (United States)

    Pinxten, Wouter; Lievens, John

    2014-09-01

    In this article we adopt a Bourdieu-based approach to study social inequalities in perceptions of mental and physical health. Most research takes into account the impact of economic or social capital on health inequalities. Bourdieu, however, distinguishes between three forms of capital that can determine peoples' social position: economic, social and cultural capital. Health research examining the effects of cultural capital is scarce. By simultaneously considering and modelling indicators of each of Bourdieu's forms of capital, we further the understanding of the dynamics of health inequalities. Using data from a large-scale representative survey (N = 1825) in Flanders, Belgium, we find that each of the forms of capital has a net effect on perceptions of physical and mental health, which persists after controlling for the other forms of capital and for the effects of other correlates of perceived health. The only exception is that the cultural capital indicators are not related to mental health. These results confirm the value of a Bourdieu-based approach and indicate the need to consider economic, social and cultural capital to obtain a better understanding of social inequality in health. © 2014 The Authors. Sociology of Health & Illness © 2014 Foundation for the Sociology of Health & Illness/John Wiley & Sons Ltd.

  6. Surveying the experiences and perceptions of undergraduate nursing students of a flipped classroom approach to increase understanding of drug science and its application to clinical practice.

    Science.gov (United States)

    Hanson, Julie

    2016-01-01

    Patient harm from medication error is a significant issue. Individual failures by health professionals including knowledge deficits and poor communication have been identified as increasing the likelihood of medication administration errors. In Australia, the National Strategy for Quality Use of Medicines in 2002 compels health professionals to have the knowledge and skills to use medicines safely and effectively. This paper examines nursing students' perceptions of the effectiveness of a flipped classroom approach to increase understanding of pharmacology principles and the application of this knowledge to medication practice. An internet-based self-completion questionnaire was used in 2013 (n = 26) after the flipped classroom approach was implemented, and pre- (n = 6) and post-flipping (n = 25) in 2014. Students who engaged with digitally recorded lectures (eLectures) prior to face-to-face workshops stated that they had greater understanding of the subject and enhanced critical thinking skills. The replay function of the eLecture was perceived by some students as most beneficial to independent learning. However, for some students, time constraints meant that they relied on eLectures alone, while others preferred traditional teaching methods. Although limited by sample size and potential participant bias, the results provide insights about the flipped classroom experience from a student perspective. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Thai primary students' understanding of nature of science (NOS) in learning about force and motion for explicit NOS through STS approach

    Science.gov (United States)

    Jimakorn, Narakorn; Yuenyong, Chokchai

    2018-01-01

    This paper aimed to study of primary school students' understanding of nature of science in learning about force and motion for Explicit Nature of Science through science technology and society (STS) approach. Participants were 11 Grade 5 students who study in Baan Khongtaphet, Bothong, Chonburi, Thailand. This research regarded interpretive paradigm. The intervention of STS physics provided 4 weeks of teaching about force and motion through Yuenyong (2006) science technology and society (STS) approach. The issues of making skate board was brought into the class in order to enhance students learning about force and motion and applying knowledge for designing skate board. The intervention was also designed to allow students explicitly mentioning their ideas about nature of science related to learning activities of STS force and motion. Students' understanding of nature of science was interpreted through students' worksheets, participant observation, students' journal writing and informal interview. The findings revealed that majority of students could reflect their ideas related to many aspects of nature of science. This included Science demands and relies on empirical evidence; knowledge production in science shares many common factors and shared habits of mind, norms, logical thinking and methods; tentative of scientific knowledge; historical, cultural and social influences on science; historical, cultural and social influences on science; science and its methods cannot answer all questions. The study has implications for NOS teaching in Thailand primary school.

  8. Beyond the androgen receptor II: New approaches to understanding and treating metastatic prostate cancer; Report from the 2017 Coffey-Holden Prostate Cancer Academy Meeting.

    Science.gov (United States)

    Miyahira, Andrea K; Cheng, Heather H; Abida, Wassim; Ellis, Leigh; Harshman, Lauren C; Spratt, Daniel E; Simons, Jonathan W; Pienta, Kenneth J; Soule, Howard R

    2017-11-01

    The 2017 Coffey-Holden Prostate Cancer Academy (CHPCA) Meeting, "Beyond the Androgen Receptor II: New Approaches to Understanding and Treating Metastatic Prostate Cancer," was held in Carlsbad, California from June 14-17, 2017. The CHPCA is an annual scientific conference hosted by the Prostate Cancer Foundation (PCF) that is uniquely designed to produce extensive and constructive discussions on the most urgent and impactful topics concerning research into the biology and treatment of metastatic prostate cancer. The 2017 CHPCA Meeting was the 5th meeting in this annual series and was attended by 71 investigators focused on prostate cancer and a variety of other fields including breast and ovarian cancer. The discussions at the meeting were concentrated on topics areas including: mechanisms and therapeutic approaches for molecular subclasses of castrate resistant prostate cancer (CRPC), the epigenetic landscape of prostate cancer, the role of DNA repair gene mutations, advancing the use of germline genetics in clinical practice, radionuclides for imaging and therapy, advances in molecular imaging, and therapeutic strategies for successful use of immunotherapy in advanced prostate cancer. This article reviews the presentations and discussions from the 2017 CHPCA Meeting in order to disseminate this knowledge and accelerate new biological understandings and advances in the treatment of patients with metastatic prostate cancer. © 2017 Wiley Periodicals, Inc.

  9. Understanding Analysis Macroscopic, microscopic, and Acid-Base Titration Symbolic Student Class XI Science High School and Improvement Efforts Microscopy Approach

    Directory of Open Access Journals (Sweden)

    Putu Indrayani

    2014-06-01

    Full Text Available Analisis Pemahaman Makroskopik, Mikroskopik, dan Simbolik Titrasi Asam-Basa Siswa Kelas XI IPA SMA serta Upaya Perbaikannya dengan Pendekatan Mikroskopik Abstract: This study aims to determine: (1 the level of understanding of the macroscopic, microscopic and symbolic students; (2 the error understanding of macroscopic, microscopic and symbolic students; (3 the effectiveness of the microscopic approach in an effort to improve students' ability to solve the problems macroscopic, symbolic and microscopic material acid-base titration. This research uses descriptive research design and quasi-experimental research design. Data research is the understanding of macroscopic, symbolic and microscopic students on the material acid-base titration. Student comprehension test measured with instruments that include: (1 macroscopic comprehension tests, (2 test the understanding of symbolic, and (3 understanding of the microscopic tests. Content validity was tested by a team of experts and the reliability of test questions macroscopic and microscopic calculated using the Spearman-Brown while reliability symbolic test item was calculated using Cronbach's Alpha. Data were analyzed using descriptive analysis and statistical tests using Anacova. Results of the study are as follows. (1 The level of understanding of the macroscopic students is high, while the symbolic and microscopic levels of understanding of students is very low. (2 Errors identified macroscopic understanding is that students do not understand that the color shown by indicators related to the nature of the solution. Symbolic understanding of the identified errors are: (i the student can not write ionization reaction; and (ii students can not choose the formula used to calculate the pH of the solution. Errors identified microscopic understanding is that students can not provide a microscopic picture of a solution of a strong acid, strong base, weak acid, weak base, and salt solutions because they do

  10. Neighborhood-resources for the development of a strong SOC and the importance of understanding why and how resources work: a grounded theory approach

    Directory of Open Access Journals (Sweden)

    Ruca Maass

    2017-09-01

    Full Text Available Abstract Background Providing individuals with psychosocial resources such as sense of coherence (SOC seems a beneficial strategy for health promotion in the neighborhood. In order to become a supporting theory for health promotion, Salutogenesis should renew its focus on resources for health, and explore how the development of a strong SOC can be facilitated. Methods Relevant issues were explored using a Grounded Theory- approach. Three focus-group-sessions and three in-depth interviews were conducted with strategically sampled participants. The transcripts of the focus groups were initially analyzed line-by-line to ensure that insights emerged from the data. We then applied focused and systemic analyses to achieve axial coding, and to include insights into how social interactions during focus groups may reveal social processes in real-life-neighborhoods. The data from the in-depth interviews were used to validate and fill emerging categories, as well as to ensure data-saturation. Results Findings indicate the importance of repeated experiences with resources and every-day-challenges to develop a strong SOC. Active engagement with resources is a favorable condition for significant experiences, which enhance the internalization of resources. Core experiences are characterized by a re-organization of resources. Participation in intellectual meaning-making through equal power dialogue seems to broaden perspectives and promote the strengthening of SOC. A strong SOC can also be described as a deeper understanding of how and why resources work, which allows for a more flexible use of resources, including replacing missing resources. Conclusion A new understanding of SOC as an intuitive understanding of how, why and under which circumstances resources work, as well as a new focus on everyday life and repeated experiences might facilitate new approaches to a purposeful strengthening of SOC through the planning and implementation of public measures.

  11. Understanding diversity in coral-algal symbiosis: a cluster-based approach to interpreting fine-scale genetic variation in the genus Symbiodinium

    Science.gov (United States)

    Correa, A. M. S.; Baker, A. C.

    2009-03-01

    Reef corals associate with an extraordinary diversity of dinoflagellate endosymbionts (genus Symbiodinium), and this diversity has become critical to understanding how corals respond to environmental changes. A popular molecular marker for Symbiodinium diversity, the Internal Transcribed Spacer-2 (ITS-2) region of ribosomal DNA, has revealed hundreds of distinct variants that are generally interpreted as representing different species, even though many have not been systematically tested for functional or ecological differentiation. Many of these variants are only minimally divergent from one another (1 bp or less), and others occupy basal nodes of traditional species phylogenies (“living ancestors”), indicating that some Symbiodinium ITS-2 diversity may represent intraspecific sequence variation. This hypothesis was tested for Symbiodinium clades A- D (the dominant symbionts of reef corals) through the construction of statistical parsimony networks of ITS-2 sequence diversity, and identification of clusters of closely related sequences within these networks. Initial assessments indicated that ecological differentiation exists between, but not within, these clusters. This approach, although imperfect in its ability to identify species boundaries in all cases, nevertheless dramatically reduces “species” diversity in Symbiodinium (from ~175 to 35). This testable alternative hypothesis indicates that, in Symbiodinium, “species” consist of clusters of closely related ITS-2 sequences diverging from ancestral variants that are typically ecologically dominant. A cluster-based view of Symbiodinium ITS-2 diversity improves our ability to: (1) construct well-supported symbiont phylogenies; (2) establish functional niches for symbiont species; and (3) understand flexibility and specificity within coral-algal symbioses. This cluster-based approach can ultimately be integrated with emerging population-level datasets (microsatellites and microsatellite flanking

  12. Combining multiple approaches and optimized data resolution for an improved understanding of stream temperature dynamics of a forested headwater basin in the Southern Appalachians

    Science.gov (United States)

    Belica, L.; Mitasova, H.; Caldwell, P.; McCarter, J. B.; Nelson, S. A. C.

    2017-12-01

    Thermal regimes of forested headwater streams continue to be an area of active research as climatic, hydrologic, and land cover changes can influence water temperature, a key aspect of aquatic ecosystems. Widespread monitoring of stream temperatures have provided an important data source, yielding insights on the temporal and spatial patterns and the underlying processes that influence stream temperature. However, small forested streams remain challenging to model due to the high spatial and temporal variability of stream temperatures and the climatic and hydrologic conditions that drive them. Technological advances and increased computational power continue to provide new tools and measurement methods and have allowed spatially explicit analyses of dynamic natural systems at greater temporal resolutions than previously possible. With the goal of understanding how current stream temperature patterns and processes may respond to changing landcover and hydroclimatoligical conditions, we combined high-resolution, spatially explicit geospatial modeling with deterministic heat flux modeling approaches using data sources that ranged from traditional hydrological and climatological measurements to emerging remote sensing techniques. Initial analyses of stream temperature monitoring data revealed that high temporal resolution (5 minutes) and measurement resolutions (geospatial models of subcanopy solar radiation and channel morphology were used to develop hypotheses and guide field data collection for further heat flux modeling. By integrating multiple approaches and optimizing data resolution for the processes being investigated, small, but ecologically significant differences in stream thermal regimes were revealed. In this case, multi-approach research contributed to the identification of the dominant mechanisms driving stream temperature in the study area and advanced our understanding of the current thermal fluxes and how they may change as environmental conditions

  13. Understanding Africa: A Geographic Approach

    Science.gov (United States)

    2009-01-01

    caused by parasites of the genus Plasmodium and is spread to humans by the bite of infected Anopheles mosquitoes. Thus, in terms commonly used by...larvae of the worm live in freshwater copepods, often referred to as water fleas, of the genus Cyclops. When humans drink contaminated water, the...purchase equity stakes in, explore for, and produce petroleum in foreign oil fields. While the equity stakes concept thus far accounts for only 600,000

  14. Evolutionary approaches to understanding sleep.

    Science.gov (United States)

    Lee Kavanau, J

    2005-04-01

    A major controversy over REM sleep's role in memory processing may owe to inadequate allowances for the highly conservative nature of evolutionary adaptations. The controversy hinges on whether NREM sleep, alone, retains primitive memory processing capabilities. The selective pressure for primitive sleep, is thought to have been the need to obviate conflicts between enormous neural processing requirements of complex visual analysis and split-second control of movements, on the one hand, and memory processing, on the other. The most efficient memory processing during mammalian and avian sleep appears to be a two-step process: synapses in individual component circuits of events are reinforced primarily by slow brain waves during NREM sleep, with the reinforced components temporally bound by fast waves, and manifested as dreams, during REM sleep. This dual action could account for partitioning of sleep periods into multiple NREM-REM cycles. It is proposed that in the absence of REM sleep, all needed memory processing can be accomplished by NREM sleep, alone, though less efficiently. Many symptoms of fatal familial insomnia are attributed to subnormal nightly reinforcement of brain circuitry because of almost total loss of sleep, and compensatory responses thereto during waking. During this disorder, sensory circuitry seemingly is spared by virtue of its supernormal reinforcement during almost continuous waking. Contrariwise, sparing of an adult's 'higher faculties' in encephalitis lethargica appears to owe to supernormal circuit reinforcement during almost continuous sleep.

  15. Understanding and Approaching Muslim Visibilities

    DEFF Research Database (Denmark)

    Schmidt, Garbi

    2011-01-01

    . Another path, which I pursue here, is to situate the activism of Muslims in the historical fabric of the neighbourhood(s) in which they live, in this case the Copenhagen neighbourhood of Nrrebro. Given that Muslims and others use Nrrebro as they do, this neighbourhood has become a prominent example......-reflexivity and critical ethnography (Clifford and Marcus 1986; Madison 2005)....

  16. Three Approaches to Understanding and Classifying Mental Disorder: ICD-11, DSM-5, and the National Institute of Mental Health's Research Domain Criteria (RDoC).

    Science.gov (United States)

    Clark, Lee Anna; Cuthbert, Bruce; Lewis-Fernández, Roberto; Narrow, William E; Reed, Geoffrey M

    2017-09-01

    The diagnosis of mental disorder initially appears relatively straightforward: Patients present with symptoms or visible signs of illness; health professionals make diagnoses based primarily on these symptoms and signs; and they prescribe medication, psychotherapy, or both, accordingly. However, despite a dramatic expansion of knowledge about mental disorders during the past half century, understanding of their components and processes remains rudimentary. We provide histories and descriptions of three systems with different purposes relevant to understanding and classifying mental disorder. Two major diagnostic manuals-the International Classification of Diseases and the Diagnostic and Statistical Manual of Mental Disorders-provide classification systems relevant to public health, clinical diagnosis, service provision, and specific research applications, the former internationally and the latter primarily for the United States. In contrast, the National Institute of Mental Health's Research Domain Criteria provides a framework that emphasizes integration of basic behavioral and neuroscience research to deepen the understanding of mental disorder. We identify four key issues that present challenges to understanding and classifying mental disorder: etiology, including the multiple causality of mental disorder; whether the relevant phenomena are discrete categories or dimensions; thresholds, which set the boundaries between disorder and nondisorder; and comorbidity, the fact that individuals with mental illness often meet diagnostic requirements for multiple conditions. We discuss how the three systems' approaches to these key issues correspond or diverge as a result of their different histories, purposes, and constituencies. Although the systems have varying degrees of overlap and distinguishing features, they share the goal of reducing the burden of suffering due to mental disorder.

  17. Information-Theoretic Approach May Shed a Light to a Better Understanding and Sustaining the Integrity of Ecological-Societal Systems under Changing Climate

    Science.gov (United States)

    Kim, J.

    2016-12-01

    Considering high levels of uncertainty, epistemological conflicts over facts and values, and a sense of urgency, normal paradigm-driven science will be insufficient to mobilize people and nation toward sustainability. The conceptual framework to bridge the societal system dynamics with that of natural ecosystems in which humanity operates remains deficient. The key to understanding their coevolution is to understand `self-organization.' Information-theoretic approach may shed a light to provide a potential framework which enables not only to bridge human and nature but also to generate useful knowledge for understanding and sustaining the integrity of ecological-societal systems. How can information theory help understand the interface between ecological systems and social systems? How to delineate self-organizing processes and ensure them to fulfil sustainability? How to evaluate the flow of information from data through models to decision-makers? These are the core questions posed by sustainability science in which visioneering (i.e., the engineering of vision) is an essential framework. Yet, visioneering has neither quantitative measure nor information theoretic framework to work with and teach. This presentation is an attempt to accommodate the framework of self-organizing hierarchical open systems with visioneering into a common information-theoretic framework. A case study is presented with the UN/FAO's communal vision of climate-smart agriculture (CSA) which pursues a trilemma of efficiency, mitigation, and resilience. Challenges of delineating and facilitating self-organizing systems are discussed using transdisciplinary toold such as complex systems thinking, dynamic process network analysis and multi-agent systems modeling. Acknowledgments: This study was supported by the Korea Meteorological Administration Research and Development Program under Grant KMA-2012-0001-A (WISE project).

  18. A multi-layered mechanistic modelling approach to understand how effector genes extend beyond phytoplasma to modulate plant hosts, insect vectors and the environment.

    Science.gov (United States)

    Tomkins, Melissa; Kliot, Adi; Marée, Athanasius Fm; Hogenhout, Saskia A

    2018-03-13

    Members of the Candidatus genus Phytoplasma are small bacterial pathogens that hijack their plant hosts via the secretion of virulence proteins (effectors) leading to a fascinating array of plant phenotypes, such as witch's brooms (stem proliferations) and phyllody (retrograde development of flowers into vegetative tissues). Phytoplasma depend on insect vectors for transmission, and interestingly, these insect vectors were found to be (in)directly attracted to plants with these phenotypes. Therefore, phytoplasma effectors appear to reprogram plant development and defence to lure insect vectors, similarly to social engineering malware, which employs tricks to lure people to infected computers and webpages. A multi-layered mechanistic modelling approach will enable a better understanding of how phytoplasma effector-mediated modulations of plant host development and insect vector behaviour contribute to phytoplasma spread, and ultimately to predict the long reach of phytoplasma effector genes. Copyright © 2018. Published by Elsevier Ltd.

  19. From one plot to many and from hillslopes to streams: Improving our understanding of catchment hydrology with a multi-scale experimental approach

    Science.gov (United States)

    Blume, Theresa; Weiler, Markus; Angermann, Lisa; Beiter, Daniel; Hassler, Sibylle; Kaplan, Nils; Lieder, Ernestine; Sprenger, Matthias

    2017-04-01

    Sustainable water resources management needs to be based on sound process understanding. This is especially true in a changing world, where boundary conditions change and models calibrated to the status quo are no longer helpful. There is a general agreement in the hydrologic community that we are in need of a better process understanding and that one of the most promising ways to achieve this is by using nested experimental designs that cover a range of scales. In the here presented study we argue that while we might be able to investigate a certain process at a plot or hillslope in detail, the real power of advancing our understanding lies in site intercomparison and if possible knowledge transfer and generalization. The experimental design of the CAOS observatory is based on sensor clusters measuring ground-, soil and stream water, sap flow and climate variables in 45 hydrological functional units which were chosen from a matrix of site characteristics (geology, land use, hillslope aspect, and topographic positions). This design allows for site intercomparisons that are based on more than one member per class and thus does not only characterize between class differences but also attempts to identify within-class variability. These distributed plot scale investigations offer a large amount of information on plot scale processes and their variability in space and time (e.g. water storage dynamics and patterns, vertical flow processes and vadose zone transit times, transpiration dynamics and patterns). However, if we want to improve our understanding of runoff generation (and thus also of nutrient and contaminant transport and export to the stream) we need to also understand how these plots link up within hillslopes and how and when these hillslopes are connected to the stream. And certainly, this is again most helpful if we do not focus on single sites but attempt experimental designs that aim at intercomparison and generalization. At the same time, the

  20. Earthworms and in vitro physiologically-based extraction tests: complementary tools for a holistic approach towards understanding risk at arsenic-contaminated sites.

    Science.gov (United States)

    Button, Mark; Watts, Michael J; Cave, Mark R; Harrington, Chris F; Jenkin, Gawen T

    2009-04-01

    The relationship of the total arsenic content of a soil and its bioaccumulation by earthworms (Lumbricus rubellus and Dendrodrilus rubidus) to the arsenic fraction bioaccessible to humans, measured using an in vitro physiologically-based extraction test (PBET), was investigated. Soil and earthworm samples were collected at 24 sites at the former arsenic mine at the Devon Great Consols (DGC) in southwest England (UK), along with an uncontaminated site in Nottingham, UK, for comparison. Analysis of soil and earthworm total arsenic via inductively coupled plasma mass spectrometry (ICP-MS) was performed following a mixed acid digestion. Arsenic concentrations in the soil were elevated (204-9,025 mg kg(-1)) at DGC. The arsenic bioaccumulation factor (BAF) for both earthworm species was found to correlate positively with the human bioaccessible fraction (HBF), although the correlation was only significant (P earthworms as complementary tools is explored as a holistic and multidisciplinary approach towards understanding risk at contaminated sites. Arsenic resistant earthworm species such as the L. rubellus populations at DGC are presented as a valuable tool for understanding risk at highly contaminated sites.