Applications of the Buckeye GTA Corpus for L2 teaching and research

DEFF Research Database (Denmark)

Hardman, Jocelyn; McCullough, Elizabeth

The Buckeye GTA Corpus contains 9,664 L1 and L2 sentence productions by 89 talkers (27 American English, 19 Hindi, 23 Mandarin, & 20 Korean). A total of 5,696 sentences were read in English, with each talker contributing 64 sentences. Hindi, Mandarin, and Korean talkers also read 64 sentences each...

Analysis of the response of PVA-GTA Fricke-gel dosimeters with clinical magnetic resonance imaging

Science.gov (United States)

Collura, Giorgio; Gallo, Salvatore; Tranchina, Luigi; Abbate, Boris Federico; Bartolotta, Antonio; d'Errico, Francesco; Marrale, Maurizio

2018-01-01

Fricke gel dosimeters produced with a matrix of Poly-vinyl alcohol (PVA) cross-linked with glutaraldehyde (GTA) were analyzed with magnetic resonance imaging (MRI). Previous studies based on spectrophotometry showed valuable dosimetric features of these gels in terms of X-ray sensitivity and diffusion of the ferric ions produced after irradiation. In this study, MRI was performed on the gels at 1.5 T with a clinical scanner in order to optimize the acquisition parameters and obtain high contrast between irradiated and non-irradiated samples. The PVA gels were found to offer good linearity in the range of 0-10 Gy and a stable signal for several hours after irradiation. The sensitivity was about 40% higher compared to gels produced with agarose as gelling agent. The effect of xylenol orange (XO) on the MRI signal was also investigated: gel dosimeters made without XO show higher sensitivity to x-rays than those made with XO. The dosimetric accuracy of the 3D gels was investigated by comparing their MRI response to percentage depth dose and transversal dose profile measurements made with an ionization chamber in a water phantom. The comparison of PVA-GTA gels with and without XO showed that the chelating agent reduces the MRI sensitivity of the gels. Depth-dose and transversal dose profiles acquired by PVA-GTA gels without XO are more accurate and consistent with the ionization chamber data. However, diffusion effects hinder accurate measurements in the steep dose gradient regions and they should be further reduced by modifying the gel matrix and/or by minimizing the delay between irradiation and imaging.

Carbide precipitation in the heat affected zone of a GTA weld in 21-6-9 stainless steel

International Nuclear Information System (INIS)

Carr, M.J.; Thorvaldson, W.G.

1979-01-01

Grain boundary precipitation was observed in a multipass GTA weld in 21-6-9 stainless steel. The precipitate was identified by electron diffraction as M 23 C 6 -type carbide. The presence of these carbide particles did not cause intergranular attack in standard corrosion tests

Automated intelligent emergency assesment of GTA pipeline events

Energy Technology Data Exchange (ETDEWEB)

Asgary, Ali; Ghaffari, Alireza; Kong, Albert [University of York, Toronto, (Canada)

2010-07-01

The traditional approach used for risk assessment in pipeline operations is stochastic, using probabilities of events. This paper reports on an investigation into the deployment of an automated intelligence reasoning system used in decision support for risk assessments related to oil and gas emergencies in the Greater Toronto Area (GTA). The study evaluated the use of fuzzy interference rules encoded using JESS and fuzzy J to develop a risk assessment system. Real time data from web services such as weather, Geographic Information Systems (GIS) and Supervisory Control and Data Acquisition (SCADA) systems were used. This study took into consideration the most recent communications infrastructure and technologies, involving the most advanced human machine interface (HMI) access via hypertext transfer protocol (HTTP). This new approach will support decision making in emergency response scenarios. The study showed that the convergence of several technologies may change the automated intelligence system design paradigm.

Deformation behavior of a 16-8-2 GTA weld as influenced by its solidification substructure

International Nuclear Information System (INIS)

Foulds, J.R.; Moteff, J.; Sikka, V.K.; McEnerney, J.W.

1983-01-01

Weldment sections from formed and welded type 316 stainless steel pipe are characterized with respect to some time-independent (tensile) and time-dependent (creep) mechanical properties at temperatures between 25 0 C and 649 0 C. The GTA weldment, welded with 16-8-2 filler metal, is sectioned from pipe in the formed + welded + solution annealed + straightened condition, as well as in the same condition with an additional re-solution treatment. Detailed room temperature microhardness measurements on these sections before and after reannealing enable a determination of the different recovery characteristics of weld and base metal. The observed stable weld metal solidification dislocation substructure in comparison with the base metal random dislocation structure, in fact, adequately explains weld/base metal elevated temperature mechanical behavior differences from this recovery characteristic standpoint. The weld metal substructure is the only parameter common to the variety of austenitic stainless steel welds exhibiting the consistent parent/weld metal deformation behavior differences described. As such, it must be considered the key to understanding weldment mechanical behavior

Conduct of everyday life and social self-understanding after depression

DEFF Research Database (Denmark)

Hybholt, Lisbeth; Mørck, Line Lerche

2015-01-01

This paper theoretically and empirically explores critical psychological conceptualisations of conduct of everyday life and social self-understanding. The analysis of conduct of everyday life for people who have been hospitalized with depression shows experiences of doubleness. We understand...... doubleness as dilemmas, conflicts and contradictions in the conduct of everyday life. The case analysis of Steven serves to illustrate how cyclic routines can matter, fulfilling meaning in life and being both in conflict and contradiction to other concerns and aspects of meaning that vary over time....... The paper empirically how these kind of conflicts, dilemmas and contradictions are much more complex, than what is possible to grasp in Holzkamp's understanding of conduct of everyday life (Holzkamp, 1998), which tends to produce dualistic opposition between cyclic everyday conduct (such as everyday life...

Nurses' Experiences of End-of-life Care in Long-term Care Hospitals in Japan: Balancing Improving the Quality of Life and Sustaining the Lives of Patients Dying at Hospitals

Directory of Open Access Journals (Sweden)

Ryo Odachi, RN, MA

2017-09-01

Full Text Available Summary: Purpose: In Japan, about 80% of deaths occur in hospitals, especially long-term care beds. The purpose of this study was to clarify the nursing practices used for such older patients at the end-of-life stage in long-termcare wards via the modified grounded theory approach (M-GTA. Methods: Data were obtained through semi-structured interviews of nineteen nurses working in cooperating long-term care wards, acute care wards, or hospice services (to allow for constant comparison between these types of wards in western Japan in 2014. We analyzed the transcribed data using M-GTA. Results: The core category that emerged from the analysis was “Balancing enhancement of patients' daily life quality and life-sustaining care in the face of uncertainty about the patients' character.” Eleven categories emerged, such as Seeking older patients' character with their family, Supporting families' decision making, Rebuilding patients' daily life in the ward, and Sustaining patients' life span through medical care. Conclusions: Nurses experienced uncertainty about the care needs of older patients, the ethical problems of Enhancing the patients' QOL by using risky care, and the evaluation criteria used to judge their own nursing care after the patients' death. All nurses had the goal of ensuring a natural death for all patients. Nurses' acceptance and evaluation of their own care was critically influenced by the patient's family's responses to their care after patients' death. Further research is necessary to develop evaluation criteria and educational programs for end-of-life nursing care of older adults. Keywords: terminal care, aged, long-term care, qualitative research

Understanding, Predicting, and Preventing Life Changing and Life Threatening Health Changes among Aging Veterans and Civilians with Spinal Cord Injury

Science.gov (United States)

2017-10-01

AWARD NUMBER: W81XWH-16-1-0629 TITLE: Understanding, Predicting, and Preventing Life -Changing and Life -Threatening Health Changes among Aging...Annual 3. DATES COVERED 30 Sep 2016 - 29 Sep 2017 4. TITLE AND SUBTITLE Understanding, Predicting, and Preventing Life -Changing and Life ... hope of preventing them. Our purpose is to better understand the how and why of the development of negative health spirals and how they may best be

Can understanding squid life-history strategies and recruitment ...

African Journals Online (AJOL)

Can understanding squid life-history strategies and recruitment improve management? ... range of potentially limiting conditions in different years, they store genetic diversity and stabilize recruitment in time. ... AJOL African Journals Online.

Strategic responses to fiscal constraints: a health policy analysis of hospital-based ambulatory physical therapy services in the Greater Toronto Area (GTA).

Science.gov (United States)

Landry, Michel D; Verrier, Molly C; Williams, A Paul; Zakus, David; Deber, Raisa B

2009-01-01

Ambulatory physical therapy (PT) services in Canada are required to be insured under the Canada Health Act, but only if delivered within hospitals. The present study analyzed strategic responses used by hospitals in the Greater Toronto Area (GTA) to deliver PT services in an environment of fiscal constraint. Key informant interviews (n = 47) were conducted with participants from all hospitals located within the GTA. Two primary strategic responses were identified: (1) "load shedding" through the elimination or reduction of services, and (2) "privatization" through contracting out or creating internal for-profit subsidiary clinics. All hospitals reported reductions in service delivery between 1996 and 2003, and 15.0% (7/47 hospitals) fully eliminated ambulatory services. Although only one of 47 hospitals contracted out services, another 15.0% (7/47) reported that for-profit subsidiary clinics were created within the hospital in order to access other more profitable forms of quasi-public and private funding. Strategic restructuring of services, aimed primarily at cost containment, may have yielded short-term financial savings but has also created a ripple effect across the continuum of care. Moreover, the rise of for-profit subsidiary clinics operating within not-for-profit hospitals has emerged without much public debate and with little research to evaluate its impact.

Thermal and Fluid Modeling of the CRYogenic Orbital TEstbed (CRYOTE) Ground Test Article (GTA)

Science.gov (United States)

Piryk, David; Schallhorn, Paul; Walls, Laurie; Stopnitzky, Benny; Rhys, Noah; Wollen, Mark

2012-01-01

The purpose of this study was to anchor thermal and fluid system models to data acquired from a ground test article (GTA) for the CRYogenic Orbital TEstbed - CRYOTE. To accomplish this analysis, it was broken into four primary tasks. These included model development, pre-test predictions, testing support at Marshall Space Flight Center (MSFC} and post-test correlations. Information from MSFC facilitated the task of refining and correlating the initial models. The primary goal of the modeling/testing/correlating efforts was to characterize heat loads throughout the ground test article. Significant factors impacting the heat loads included radiative environments, multi-layer insulation (MLI) performance, tank fill levels, tank pressures, and even contact conductance coefficients. This paper demonstrates how analytical thermal/fluid networks were established, and it includes supporting rationale for specific thermal responses seen during testing.

Adaptive control of penetration and joint following for robotic GTA welding

International Nuclear Information System (INIS)

Bahram Mir Sadeghi; Hishamuddin Jamaludin; Iskandar Baharin

1997-01-01

A statistical-based method for adaptive control of weld pool penetration and joint following in Tungsten Inert Gas Welding as an approach to process and trajectory control of robotic GTA welding has been designed and simulated. Welding process parameters such as: base current and time, pulse current and time, electrode tip to work piece distance, filler travelling speed, torch speed and work piece thickness were used for finding the equations which describe the interrelationship between the aforementioned variables and penetration depth as well as bead width. The calculation of these equations was developed from the statistical regression analysis of 80 welds deposited using various combinations of welding parameters. For monitoring of the work piece thickness variations, an ultrasonic device was used. In order to control the weld trajectory, a CCD camera was also used. The results showed that the misalignment of the progressive heat affected zone which is adjacent to the weld puddle can be detected, and used for control of the weld trajectory. Also, it was found that scanning of a certain region of the captured image in front of the weld puddle decreases the data processing time drastically

Improving the corrosion properties of magnesium AZ31 alloy GTA weld metal using microarc oxidation process

Institute of Scientific and Technical Information of China (English)

M.Siva Prasad; M.Ashfaq; N.Kishore Babu; A.Sreekanth; K.Sivaprasad; V.Muthupandi

2017-01-01

In this work,the morphology,phase composition,and corrosion properties of microarc oxidized (MAO) gas tungsten arc (GTA) weldments of AZ31 alloy were investigated.Autogenous gas tungsten arc welds were made as full penetration bead-on-plate welding under the alternating-current mode.A uniform oxide layer was developed on the surface of the specimens with MAO treatment in silicate-based alkaline electrolytes for different oxidation times.The corrosion behavior of the samples was evaluated by potentiodynamic polarization and electrochemical impedance spectroscopy.The oxide film improved the corrosion resistance substantially compared to the uncoated specimens.The sample coated for 10 min exhibited better corrosion properties.The corrosion resistance of the coatings was concluded to strongly depend on the morphology,whereas the phase composition and thickness were concluded to only slightly affect the corrosion resistance.

Parameter study of temperature distribution in a work-piece during dry hyperbaric GTA-welding

International Nuclear Information System (INIS)

Fulfs, H.

1989-01-01

In a sensitivity study the influence of initial and boundary welding parameters upon the spatial and temporal temperature distribution in a work-piece during dry hyperbaric GTA-welding is investigated. It will be shown that at constant arc current a variation of pressure (1-60 bar), arc length (3-10 mm), welding speed (1-2.5 mm/s) or the initial temperature (20-200deg C) of the work-piece to some extend significantly influences the size of melt and heat affected zone as well as the maximum temperature and cooling behaviour of the work-piece; compared to this no mentionable effects of shielding gas temperature (20-300deg C) or flow rate (10-500 dm N 3 /min) on the thermal condition of the work-piece can be recognized. The discovered relationships have been approximated by simple correlations, which can be used for parameter optimization and process control. (orig.) With 33 figs., 4 tabs [de

A Conceptual Framework for Graduate Teaching Assistant Professional Development Evaluation and Research.

Science.gov (United States)

Reeves, Todd D; Marbach-Ad, Gili; Miller, Kristen R; Ridgway, Judith; Gardner, Grant E; Schussler, Elisabeth E; Wischusen, E William

2016-01-01

Biology graduate teaching assistants (GTAs) are significant contributors to the educational mission of universities, particularly in introductory courses, yet there is a lack of empirical data on how to best prepare them for their teaching roles. This essay proposes a conceptual framework for biology GTA teaching professional development (TPD) program evaluation and research with three overarching variable categories for consideration: outcome variables, contextual variables, and moderating variables. The framework's outcome variables go beyond GTA satisfaction and instead position GTA cognition, GTA teaching practice, and undergraduate learning outcomes as the foci of GTA TPD evaluation and research. For each GTA TPD outcome variable, key evaluation questions and example assessment instruments are introduced to demonstrate how the framework can be used to guide GTA TPD evaluation and research plans. A common conceptual framework is also essential to coordinating the collection and synthesis of empirical data on GTA TPD nationally. Thus, the proposed conceptual framework serves as both a guide for conducting GTA TPD evaluation at single institutions and as a means to coordinate research across institutions at a national level. © 2016 T. D. Reeves et al. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Learning to teach effectively: Science, technology, engineering, and mathematics graduate teaching assistants' teaching self-efficacy

Science.gov (United States)

Dechenne, Sue Ellen

Graduate teaching assistants (GTAs) from science, technology, engineering, and mathematics (STEM) are important in the teaching of undergraduate students (Golde & Dore, 2001). However, they are often poorly prepared for teaching (Luft, Kurdziel, Roehrig, & Turner, 2004). This dissertation addresses teaching effectiveness in three related manuscripts: (1) A position paper that summarizes the current research on and develops a model of GTA teaching effectiveness. (2) An adaptation and validation of two instruments; GTA perception of teaching training and STEM GTA teaching self-efficacy. (3) A model test of factors that predict STEM GTA teaching self-efficacy. Together these three papers address key questions in the understanding of teaching effectiveness in STEM GTAs including: (a) What is our current knowledge of factors that affect the teaching effectiveness of GTAs? (b) Given that teaching self-efficacy is strongly linked to teaching performance, how can we measure STEM GTAs teaching self-efficacy? (c) Is there a better way to measure GTA teaching training than currently exists? (d) What factors predict STEM GTA teaching self-efficacy? An original model for GTA teaching effectiveness was developed from a thorough search of the GTA teaching literature. The two instruments---perception of training and teaching self-efficacy---were tested through self-report surveys using STEM GTAs from six different universities including Oregon State University (OSU). The data was analyzed using exploratory and confirmatory factor analysis. Using GTAs from the OSU colleges of science and engineering, the model of sources of STEM GTA teaching self-efficacy was tested by administering self-report surveys and analyzed by using OLS regression analysis. Language and cultural proficiency, departmental teaching climate, teaching self-efficacy, GTA training, and teaching experience affect GTA teaching effectiveness. GTA teaching self-efficacy is a second-order factor combined from self

PHENOMENOLOGY OF LIFE IN UNDERSTANDING THE COSMOPOLITAN HUMANNESS

Directory of Open Access Journals (Sweden)

CARMEN COZMA

2013-05-01

Full Text Available One of the most significant directions of the world-wide contemporary philosophy, phenomenology of life of Anna-Teresa Tymieniecka represents a major path of thinking and acting for the promotion of what does mean the universal valuable in human beingness by disclosing and unfolding an essential modality of understanding and shaping some paradigms of world culture. We face an original author and a reputed activist doing exceptional work to foster a culture of dialogue in the world. The impressive Tymienieckan philosophical work has imposed itself as a great contribution to the heralding of a “New Enlightenment” encompassing humanity in the endeavour of creating, maintaining and developing the wellbeing and the common good of mankind, in securing the human common destiny. Putting in act a holistic and dynamic philosophy upon life and human condition, phenomenology of life offers a viable pattern of communication between different cultures, of overcoming any kind of contradictions in dealing with the fundamental issues of living together and sharing-in-life. We can find elements for tackling and comprehending in a better way our cosmopolitan humanness, due to the opening of a creative approach of identity and otherness, by admitting differentiation and also by working for harmony in the play of life. Throughout new concepts and a very own complex vision of the respect for life, the philosophy-in-act of AnnaTeresa Tymieniecka manifests valences of an integrator enterprise in interpreting the cosmopolitan status of the philosopher in nowadays, in affirming the role of a responsible citizen of the world.

Developing Students' Understanding of Industrially Relevant Economic and Life Cycle Assessments

Science.gov (United States)

Bode, Claudia J.; Chapman, Clint; Pennybaker, Atherly; Subramaniam, Bala

2017-01-01

Training future leaders to understand life cycle assessment data is critical for effective research, business, and sociopolitical decision-making. However, the technical nature of these life cycle reports often makes them challenging for students and other nonexperts to comprehend. Therefore, we outline here the key takeaways from recent economic…

Effect of keyhole characteristics on porosity formation during pulsed laser-GTA hybrid welding of AZ31B magnesium alloy

Science.gov (United States)

Chen, Minghua; Xu, Jiannan; Xin, Lijun; Zhao, Zuofu; Wu, Fufa; Ma, Shengnan; Zhang, Yue

2017-06-01

This paper experimentally investigates the relationship between laser keyhole characteristics on the porosity formation during pulsed laser-GTA welding of magnesium alloy. Based on direct observations during welding process, the influences of laser keyhole state on the porosity formation were studied. Results show that the porosities in the joint are always at the bottom of fusion zone of the joint, which is closely related to the keyhole behavior. A large depth to wide ratio always leads to the increase of porosity generation chance. Keeping the keyhole outlet open for a longer time benefits the porosity restriction. Overlap of adjacent laser keyhole can effectively decrease the porosity generation, due to the cutting effect between adjacent laser keyholes. There are threshold overlap rate values for laser keyholes in different state.

Helping Students Understand Intersectionality: Reflections from a Dialogue Project in Residential Life

Science.gov (United States)

Claros, Sharon Chia; Garcia, Gina A.; Johnston-Guerrero, Marc P.; Mata, Christine

2017-01-01

In this chapter, the authors share insights from a dialogue project focused on intersectionality within a residential life setting and discuss additional strategies for helping students understand intersectionality.

Life and Understanding: The Origins of "Understanding" in Self-Organizing Nervous Systems.

Science.gov (United States)

Yufik, Yan M; Friston, Karl

2016-01-01

This article is motivated by a formulation of biotic self-organization in Friston (2013), where the emergence of "life" in coupled material entities (e.g., macromolecules) was predicated on bounded subsets that maintain a degree of statistical independence from the rest of the network. Boundary elements in such systems constitute a Markov blanket ; separating the internal states of a system from its surrounding states. In this article, we ask whether Markov blankets operate in the nervous system and underlie the development of intelligence, enabling a progression from the ability to sense the environment to the ability to understand it. Markov blankets have been previously hypothesized to form in neuronal networks as a result of phase transitions that cause network subsets to fold into bounded assemblies, or packets (Yufik and Sheridan, 1997; Yufik, 1998a). The ensuing neuronal packets hypothesis builds on the notion of neuronal assemblies (Hebb, 1949, 1980), treating such assemblies as flexible but stable biophysical structures capable of withstanding entropic erosion. In other words, structures that maintain their integrity under changing conditions. In this treatment, neuronal packets give rise to perception of "objects"; i.e., quasi-stable (stimulus bound) feature groupings that are conserved over multiple presentations (e.g., the experience of perceiving "apple" can be interrupted and resumed many times). Monitoring the variations in such groups enables the apprehension of behavior; i.e., attributing to objects the ability to undergo changes without loss of self-identity. Ultimately, "understanding" involves self-directed composition and manipulation of the ensuing "mental models" that are constituted by neuronal packets, whose dynamics capture relationships among objects: that is, dependencies in the behavior of objects under varying conditions. For example, movement is known to involve rotation of population vectors in the motor cortex (Georgopoulos et al

Understanding and Supporing Knowledge Work in Everyday Life

Directory of Open Access Journals (Sweden)

Jeffrey T. Grabill

2007-03-01

Full Text Available Our purpose in writing is two-fold: (1 to introduce this audience to the Writing in Digital Environments (WIDE Research Center, and (2 to make an argument about the importance of understanding and supporting knowledge work for professional and technical communicators. We are particularly interested in what knowledge (writing work looks like in multiple contexts—for instance, in civic organizations as well as in corporate organizations— because contemporary social and community contexts are dependent on high-quality knowledge work. This explains our interest in “everyday life.”

Spatial Assessment of Road Traffic Injuries in the Greater Toronto Area (GTA: Spatial Analysis Framework

Directory of Open Access Journals (Sweden)

Sina Tehranchi

2017-03-01

Full Text Available This research presents a Geographic Information Systems (GIS and spatial analysis approach based on the global spatial autocorrelation of road traffic injuries for identifying spatial patterns. A locational spatial autocorrelation was also used for identifying traffic injury at spatial level. Data for this research study were acquired from Canadian Institute for Health Information (CIHI based on 2004 and 2011. Moran’s I statistics were used to examine spatial patterns of road traffic injuries in the Greater Toronto Area (GTA. An assessment of Getis-Ord Gi* statistic was followed as to identify hot spots and cold spots within the study area. The results revealed that Peel and Durham have the highest collision rate for other motor vehicle with motor vehicle. Geographic weighted regression (GWR technique was conducted to test the relationships between the dependent variable, number of road traffic injury incidents and independent variables such as number of seniors, low education, unemployed, vulnerable groups, people smoking and drinking, urban density and average median income. The result of this model suggested that number of seniors and low education have a very strong correlation with the number of road traffic injury incidents.

Cultural influences on children's understanding of the human body and the concept of life.

Science.gov (United States)

Panagiotaki, Georgia; Nobes, Gavin

2014-09-01

This study aimed to identify the age by which children begin to demonstrate a biological understanding of the human body and the idea that the purpose of body functioning is to maintain life. The study also explored the influence of education, culturally specific experiences and religion on knowledge acquisition in this domain. Children aged between 4 and 7 years from three different cultural backgrounds (White British, British Muslim, and Pakistani Muslim) were interviewed about the human body and its functioning. At least half of the 4- to 5-year-olds in each cultural group, and almost all 6- to 7-year-olds, referred to the maintenance of life when explaining organs' functions and so were classified as 'life theorizers'. Pakistani Muslim children gave fewer biological responses to questions about organs' functions and the purpose of eating and breathing, but referred to life more than their British counterparts. Irrespective of cultural group, older children understood organ location and function better than younger children. These findings support Jaakkola and Slaughter's (2002, Br. J. Dev. Psychol., 20, 325) view that children's understanding of the body as a 'life machine' emerges around the ages of 4-5 years. They also suggest that, despite many similarities in children's ideas cross-culturally, different educational input and culturally specific experiences influence aspects of their biological understanding. © 2014 The British Psychological Society.

Understanding Care Giving and Care Receiving Experiences throughout the Life Course

DEFF Research Database (Denmark)

Morita, Makiko

the social network of their everyday lives. These interactions are long-term changing processes as both the systems and wide-ranging conditions in everyday life are neither static nor immutable. In particular, the present paper draws attention to how older people understand the ways that the welfare systems...... and expectations for the future. Guided by life course approach, the analysis focuses on older couples in Denmark and Japan, and explores the following questions; how have older Danish and Japanese couples experienced care giving and care taking over the life course? How do they perceive these experiences? How...... data derived from semi-structured in-depth interviews with couples aged 65 and over in Denmark and Japan. The interviews are ongoing and will be concluded by February 2014....

Coming to Understand Diversity and Education: Life Experiences and Educational Opportunities

Science.gov (United States)

Chamberlain, Steven Paul

2015-01-01

Coming to understand how cultural differences influence interactions between educators and students and their parents is a complex and perhaps life-long discovery. Culture helps to define groups' belief systems and expectations for appropriate behavior, often at a hidden level. Pre-service teachers need multiple opportunities to interact with…

Understanding the creative processes of phenomenological research: The life philosophy of Løgstrup

OpenAIRE

Annelise Norlyk; Pia Dreyer; Anita Haahr; Bente Martinsen

2011-01-01

The creative processes of understanding patients’ experiences in phenomenological research are difficult to articulate. Drawing on life philosophy as represented by the Danish philosopher K.E. Løgstrup (1905-1981), this article aims to illustrate Løgstrup’s thinking as a way to elaborate the creation of cognition and understanding of patients’ experiences. We suggest that Løgstrup’s thoughts on sensation can add new dimensions to an increased understanding of the creative process of phenomeno...

Expression, purification, crystallization and preliminary X-ray characterization of a putative glycosyltransferase of the GT-A fold found in mycobacteria

Energy Technology Data Exchange (ETDEWEB)

Fulton, Zara; Crellin, Paul K.; Brammananth, Rajini; Zaker-Tabrizi, Leyla; Coppel, Ross L.; Rossjohna, Jamie; Beddoe, Travis (Monash)

2008-05-28

Glycosidic bond formation is a ubiquitous enzyme-catalysed reaction. This glycosyltransferase-mediated process is responsible for the biosynthesis of innumerable oligosaccharides and glycoconjugates and is often organism- or cell-specific. However, despite the abundance of genomic information on glycosyltransferases (GTs), there is a lack of structural data for this versatile class of enzymes. Here, the cloning, expression, purification and crystallization of an essential 329-amino-acid (34.8 kDa) putative GT of the classic GT-A fold implicated in mycobacterial cell-wall biosynthesis are reported. Crystals of MAP2569c from Mycobacterium avium subsp. paratuberculosis were grown in 1.6 M monoammonium dihydrogen phosphate and 0.1 M sodium citrate pH 5.5. A complete data set was collected to 1.8 {angstrom} resolution using synchrotron radiation from a crystal belonging to space group P4{sub 1}2{sub 1}2.

Insights Into Care Providers' Understandings of Life Story Work With Persons With Dementia: Findings From a Qualitative Study.

Science.gov (United States)

Berendonk, Charlotte; Caine, Vera

2017-08-01

In Germany, life story work, an approach which acknowledges humans as narrative beings and honors biographies, is required by health authorities to be integrated in care provided in nursing homes. Insufficient attention to life story work could place residents at risk of dehumanization, particularly residents with dementia, who depend on support of others to tell and make meaning of their life experiences. We conducted a qualitative study to gain insights into care providers' perceptions and practices of life story work with persons with dementia. Thirty-six care providers in 7 nursing homes participated in semistructured interviews or group discussions. We derived subjective theories (individual understandings) of care providers and higher-order concept patterns following the principles and processes of grounded theory. We found a great variation in participants' understandings of life story work. Some participants were unsure if and how life story work impacts persons with dementia. Starting points for improving the integration of life story work into practice are discussed. We conclude that care providers need a better understanding of life story work as a nursing intervention. The importance of the notion of humans as narrative beings and the multiple ways in which we story our lives as well as embody life stories needs to be further developed. Knowledge is required about the practical and systemic challenges of integrating life story work in the care of persons with dementia.

Toward an understanding of late life suicidal behavior: the role of lifespan developmental theory.

Science.gov (United States)

Fiske, Amy; O'Riley, Alisa A

2016-01-01

Suicidal behavior in late life differs in important ways from suicidal behavior that occurs earlier in the lifespan, suggesting the possibility of developmental differences in the etiology of suicidal behavior. This paper examines late life suicidal behavior within the context of lifespan developmental theory. This paper presents a conceptual framework for using lifespan developmental theory to better understand late life suicidal behavior. We argue that the motivational theory of lifespan development, which focuses on control, is particularly relevant to late life suicide. This theory posits that opportunities to exert control over important aspects of one's life diminish in late life as a result of declines in physical functioning and other factors, and that successful aging is associated with adaptive regulation of this developmental change. Although continued striving to meet goals is normative throughout the lifespan, most individuals also increase the use of compensatory strategies in old age or when faced with a decline in functioning. We propose that individuals who do not adapt to developmental changes by altering their strategies for exerting control will be at risk for suicidal behavior in late life. This paper reviews evidence that supports the importance of control with respect to suicidal outcomes in older adults, as well as findings regarding specific types of control strategies that may be related to suicide risk in older adults with health-related limitations. Although suicidal behavior is not a normal part of aging, the application of lifespan developmental theory may be useful in understanding and potentially preventing suicide among older adults.

Precarity in late life: Understanding new forms of risk and insecurity.

Science.gov (United States)

Grenier, Amanda; Phillipson, Chris; Laliberte Rudman, Debbie; Hatzifilalithis, Stephanie; Kobayashi, Karen; Marier, Patrik

2017-12-01

Population aging and longevity in the context of declining social commitments, raises concerns about disadvantage and widening inequality in late life. This paper explores the concept of precarity as a means to understand new and sustained forms of risk and insecurity that affect late life. The article begins with a review of the definition and uses of precarity in a range of scholarly fields including social gerontology. It then draws on illustrations from three locations of experience including older women, aging with a disability, and the foreign-born, to outline how precarity renders visible the disadvantages carried into late life, and new insecurities that emerge at the moment of needing care in the context of austerity. The argument being put forward is that precarity can be used to illustrate how risks and insecurities, experienced over time, in longevity, and the context of austerity, can deepen disadvantage. This lens thus holds the potential to challenge individual interpretations of risk, and situate experiences of disadvantage in the economic and political context. We conclude that contemporary conditions of austerity and longevity intersect to produce and sustain risk and disadvantage into late life. Copyright © 2017 Elsevier Inc. All rights reserved.

Understanding the creative processes of phenomenological research: The life philosophy of Løgstrup

Science.gov (United States)

Dreyer, Pia; Haahr, Anita; Martinsen, Bente

2011-01-01

The creative processes of understanding patients’ experiences in phenomenological research are difficult to articulate. Drawing on life philosophy as represented by the Danish philosopher K.E. Løgstrup (1905–1981), this article aims to illustrate Løgstrup's thinking as a way to elaborate the creation of cognition and understanding of patients’ experiences. We suggest that Løgstrup's thoughts on sensation can add new dimensions to an increased understanding of the creative process of phenomenological research, and that his thinking can be seen as an epistemological ground for these processes. We argue with Løgstrup that sense-based impressions can facilitate an flash of insight, i.e., the spontaneous, intuitive flash of an idea. Løgstrup stresses that an “flash of insight” is an important source in the creation of cognition and understanding. Relating to three empirical phenomenological studies of patients’ experiences, we illustrate how the notions of impression and flash of insight can add new dimensions to increased understanding of the creative processes in phenomenological research that have previously not been discussed. We illustrate that sense-based impressions can facilitate creative flash of insights that open for understanding of patients’ experiences in the research process as well as in the communication of the findings. The nature of impression and flash of insight and their relevance in the creation of cognition and understanding contributes to the sparse descriptions in the methodological phenomenological research literature of the creative processes of this research. An elaboration of the creative processes in phenomenological research can help researchers to articulate these processes. Thus, Løgstrup's life philosophy has proven to be valuable in adding new dimensions to phenomenological empirical research as well as embracing lived experience. PMID:22076123

Understanding the creative processes of phenomenological research: The life philosophy of Løgstrup

Directory of Open Access Journals (Sweden)

Annelise Norlyk

2011-11-01

Full Text Available The creative processes of understanding patients’ experiences in phenomenological research are difficult to articulate. Drawing on life philosophy as represented by the Danish philosopher K.E. Løgstrup (1905–1981, this article aims to illustrate Løgstrup's thinking as a way to elaborate the creation of cognition and understanding of patients’ experiences. We suggest that Løgstrup's thoughts on sensation can add new dimensions to an increased understanding of the creative process of phenomenological research, and that his thinking can be seen as an epistemological ground for these processes. We argue with Løgstrup that sense-based impressions can facilitate an flash of insight, i.e., the spontaneous, intuitive flash of an idea. Løgstrup stresses that an “flash of insight” is an important source in the creation of cognition and understanding. Relating to three empirical phenomenological studies of patients’ experiences, we illustrate how the notions of impression and flash of insight can add new dimensions to increased understanding of the creative processes in phenomenological research that have previously not been discussed. We illustrate that sense-based impressions can facilitate creative flash of insights that open for understanding of patients’ experiences in the research process as well as in the communication of the findings. The nature of impression and flash of insight and their relevance in the creation of cognition and understanding contributes to the sparse descriptions in the methodological phenomenological research literature of the creative processes of this research. An elaboration of the creative processes in phenomenological research can help researchers to articulate these processes. Thus, Løgstrup's life philosophy has proven to be valuable in adding new dimensions to phenomenological empirical research as well as embracing lived experience.

Understanding the creative processes of phenomenological research: The life philosophy of Løgstrup.

Science.gov (United States)

Norlyk, Annelise; Dreyer, Pia; Haahr, Anita; Martinsen, Bente

2011-01-01

The creative processes of understanding patients' experiences in phenomenological research are difficult to articulate. Drawing on life philosophy as represented by the Danish philosopher K.E. Løgstrup (1905-1981), this article aims to illustrate Løgstrup's thinking as a way to elaborate the creation of cognition and understanding of patients' experiences. We suggest that Løgstrup's thoughts on sensation can add new dimensions to an increased understanding of the creative process of phenomenological research, and that his thinking can be seen as an epistemological ground for these processes. We argue with Løgstrup that sense-based impressions can facilitate an flash of insight, i.e., the spontaneous, intuitive flash of an idea. Løgstrup stresses that an "flash of insight" is an important source in the creation of cognition and understanding. Relating to three empirical phenomenological studies of patients' experiences, we illustrate how the notions of impression and flash of insight can add new dimensions to increased understanding of the creative processes in phenomenological research that have previously not been discussed. We illustrate that sense-based impressions can facilitate creative flash of insights that open for understanding of patients' experiences in the research process as well as in the communication of the findings. The nature of impression and flash of insight and their relevance in the creation of cognition and understanding contributes to the sparse descriptions in the methodological phenomenological research literature of the creative processes of this research. An elaboration of the creative processes in phenomenological research can help researchers to articulate these processes. Thus, Løgstrup's life philosophy has proven to be valuable in adding new dimensions to phenomenological empirical research as well as embracing lived experience.

Understanding the Work-Life Interaction from a Working Time Perspective

DEFF Research Database (Denmark)

Pedersen, Vivi Bach

time not only defines the temporal structure of work, but also determines the individual’s social time. The theoretical framework is based on theories concerning influence, in particular Organizational Participation (e.g. Heller, Pusic, Strauss & Wilpert, 1998) and Self-Determination Theory (e.g. Deci...... & Ryan, 2002). Through theoretical analyses it is shown that a participatory influence approach reveals new perspectives in understanding the complexity of the work-life phenomenon and help counteracting the undesirable split-up between the existing conflict versus balance approaches. Participants from...

Practical wisdom, understanding of coherence and competencies for everyday life

DEFF Research Database (Denmark)

Benn, Jette

2009-01-01

The focus of this article is the subject home economics education in the primary and lower secondary school in the 21st century. Practical wisdom, understanding of coherence and competencies for everyday life are suggested as aims of home economics education. It is argued that these elements should...... and experiencing the profession   [1] Bildung is the German word for education, but it is used as a pedagogical term in English literature as it has another and more specific meaning than the word education. The word in Danish is dannelse....

The Life Cycle of the Child Care Center -- Understanding Center Growth and Development.

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Bess, Gary; Ratekin, Cindy

2001-01-01

Identifies the seven stages of the life cycle for child care centers: entrepreneurial; development; formalization; maturity; stagnation; death; and renewal. Suggests that critical transition points exist for organizational development, and that, if they are aware of and understand each stage of development, administrators may intervene at those…

Understanding the Determinants of Weight-Related Quality of Life among Bariatric Surgery Candidates

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Annie Tessier

2012-01-01

Full Text Available Obesity and its relation to quality of life are multifaceted. The purpose of this paper was to contribute evidence to support a framework for understanding the impact of obesity on quality of life in 42 morbidly obese subjects considering a wide number of potential determinants. A model of weight-related quality of life (WRQL was developed based on the Wilson-Cleary model, considering subjects' weight characteristics, arterial oxygen pressure (PaO2, walking capacity (6-minute walk test, 6MWT, health-related quality of life (HRQL; Physical and Mental Component Summaries of the SF-36 PCS/MCS, and WRQL. The model of WRQL was tested with linear regressions and a path analysis, which showed that as PaO2 at rest increased 6MWT increased. 6MWT was positively associated with the PCS, which in turn was positively related to WRQL along with the MCS. The model showed good fit and explained 38% of the variance in WRQL.

Understandings of how Professional Practice and Problem Definitions Influence the Possibilities of Children's Conduct of Life

DEFF Research Database (Denmark)

Røn Larsen, Maja

are being covered up by the unifying administrative processes, it seems to undermine an understanding of the way these conflicts are of importance to the child’s concrete conditions of life. So saying, a more precise comprehension of children’s actual difficulties involves the analysis of, how the process...... practices (School, institutions family etc.). However the administrative bureaucracy’s call for unambiguous determination of “special needs” undermines the comprehension of plurality of professional perspectives. In this way a gap occurs between a multifaceted understanding of the child’s conduct of life...... and the production of the “child as a case”. I intend to explore the connections between bureaucratic, interdisciplinary and professional practices that are organised to support children, including the bureaucratic process of defining children’s “special needs”. In the process different professionals understand...

Understanding the experiences of racialized older people through an intersectional life course perspective.

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Ferrer, Ilyan; Grenier, Amanda; Brotman, Shari; Koehn, Sharon

2017-04-01

This article proposes the development of an intersectional life course perspective that is capable of exploring the links between structural inequalities and the lived experience of aging among racialized older people. Merging key concepts from intersectionality and life course perspectives, the authors suggest an analytic approach to better account for the connections between individual narratives and systems of domination that impinge upon the everyday lives of racialized older people. Our proposed intersectional life course perspective includes four dimensions: 1) identifying key events and their timing, 2) examining locally and globally linked lives, 3) exploring categories of difference and how they shape identities, 4) and assessing how processes of differentiation, and systems of domination shape the lives, agency and resistance among older people. Although applicable to various forms of marginalization, we examine the interplay of racialization, immigration, labour and care in later life to highlight relationships between systems, events, trajectories, and linked lives. The illustrative case example used in this paper emerged from a larger critical ethnographic study of aging in the Filipino community in Montreal, Canada. We suggest that an intersectional life course perspective has the potential to facilitate a deeper understanding of the nexus of structural, personal and relational processes that are experienced by diverse groups of older people across the life course and into late life. Copyright © 2017 Elsevier Inc. All rights reserved.

Expression, purification, crystallization and preliminary X-ray characterization of a putative glycosyltransferase of the GT-A fold found in mycobacteria

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Fulton, Zara [The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800 (Australia); Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Victoria 3800 (Australia); Crellin, Paul K.; Brammananth, Rajini [Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Victoria 3800 (Australia); Department of Microbiology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800 (Australia); Zaker-Tabrizi, Leyla [The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800 (Australia); Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Victoria 3800 (Australia); Coppel, Ross L. [Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Victoria 3800 (Australia); Department of Microbiology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800 (Australia); Rossjohn, Jamie, E-mail: jamie.rossjohn@med.monash.edu.au; Beddoe, Travis, E-mail: jamie.rossjohn@med.monash.edu.au [The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800 (Australia); Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Victoria 3800 (Australia)

2008-05-01

MAP2569c from M. avium subsp. paratuberculosis, a putative glycosyltransferase implicated in mycobacterial cell-wall biosynthesis, was cloned, expressed, purified and crystallized. X-ray diffraction data were collected to 1.8 Å resolution. Glycosidic bond formation is a ubiquitous enzyme-catalysed reaction. This glycosyltransferase-mediated process is responsible for the biosynthesis of innumerable oligosaccharides and glycoconjugates and is often organism- or cell-specific. However, despite the abundance of genomic information on glycosyltransferases (GTs), there is a lack of structural data for this versatile class of enzymes. Here, the cloning, expression, purification and crystallization of an essential 329-amino-acid (34.8 kDa) putative GT of the classic GT-A fold implicated in mycobacterial cell-wall biosynthesis are reported. Crystals of MAP2569c from Mycobacterium avium subsp. paratuberculosis were grown in 1.6 M monoammonium dihydrogen phosphate and 0.1 M sodium citrate pH 5.5. A complete data set was collected to 1.8 Å resolution using synchrotron radiation from a crystal belonging to space group P4{sub 1}2{sub 1}2.

Expression, purification, crystallization and preliminary X-ray characterization of a putative glycosyltransferase of the GT-A fold found in mycobacteria

International Nuclear Information System (INIS)

Fulton, Zara; Crellin, Paul K.; Brammananth, Rajini; Zaker-Tabrizi, Leyla; Coppel, Ross L.; Rossjohn, Jamie; Beddoe, Travis

2008-01-01

MAP2569c from M. avium subsp. paratuberculosis, a putative glycosyltransferase implicated in mycobacterial cell-wall biosynthesis, was cloned, expressed, purified and crystallized. X-ray diffraction data were collected to 1.8 Å resolution. Glycosidic bond formation is a ubiquitous enzyme-catalysed reaction. This glycosyltransferase-mediated process is responsible for the biosynthesis of innumerable oligosaccharides and glycoconjugates and is often organism- or cell-specific. However, despite the abundance of genomic information on glycosyltransferases (GTs), there is a lack of structural data for this versatile class of enzymes. Here, the cloning, expression, purification and crystallization of an essential 329-amino-acid (34.8 kDa) putative GT of the classic GT-A fold implicated in mycobacterial cell-wall biosynthesis are reported. Crystals of MAP2569c from Mycobacterium avium subsp. paratuberculosis were grown in 1.6 M monoammonium dihydrogen phosphate and 0.1 M sodium citrate pH 5.5. A complete data set was collected to 1.8 Å resolution using synchrotron radiation from a crystal belonging to space group P4 1 2 1 2

Understanding uncertainty propagation in life cycle assessments of waste management systems

DEFF Research Database (Denmark)

Bisinella, Valentina; Conradsen, Knut; Christensen, Thomas Højlund

2015-01-01

Uncertainty analysis in Life Cycle Assessments (LCAs) of waste management systems often results obscure and complex, with key parameters rarely determined on a case-by-case basis. The paper shows an application of a simplified approach to uncertainty coupled with a Global Sensitivity Analysis (GSA......) perspective on three alternative waste management systems for Danish single-family household waste. The approach provides a fast and systematic method to select the most important parameters in the LCAs, understand their propagation and contribution to uncertainty....

Using physiology and behaviour to understand the responses of fish early life stages to toxicants.

Science.gov (United States)

Sloman, K A; McNeil, P L

2012-12-01

The use of early life stages of fishes (embryos and larvae) in toxicity testing has been in existence for a long time, generally utilizing endpoints such as morphological defects and mortality. Behavioural endpoints, however, may represent a more insightful evaluation of the ecological effects of toxicants. Indeed, recent years have seen a considerable increase in the use of behavioural measurements in early life stages reflecting a substantial rise in zebrafish Danio rerio early life-stage toxicity testing and the development of automated behavioural monitoring systems. Current behavioural endpoints identified for early life stages in response to toxicant exposure include spontaneous activity, predator avoidance, capture of live food, shoaling ability and interaction with other individuals. Less frequently used endpoints include measurement of anxiogenic behaviours and cognitive ability, both of which are suggested here as future indicators of toxicant disruption. For many simple behavioural endpoints, there is still a need to link behavioural effects with ecological relevance; currently, only a limited number of studies have addressed this issue. Understanding the physiological mechanisms that underlie toxicant effects on behaviour so early in life has received far less attention, perhaps because physiological measurements can be difficult to carry out on individuals of this size. The most commonly established physiological links with behavioural disruption in early life stages are similar to those seen in juveniles and adults including sensory deprivation (olfaction, lateral line and vision), altered neurogenesis and neurotransmitter concentrations. This review highlights the importance of understanding the integrated behavioural and physiological response of early life stages to toxicants and identifies knowledge gaps which present exciting areas for future research. © 2012 The Authors. Journal of Fish Biology © 2012 The Fisheries Society of the British Isles.

Understanding everyday life of morbidly obese adults-habits and body image

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Bjørg Christiansen

2012-07-01

Full Text Available Background: Morbid obesity is a progressive, chronic condition associated with failed attempts at change and repeated relapses. Aim: There seems to be little previous research into the understanding of the everyday life of morbidly obese adults. We wanted to gain more knowledge about characteristics of eating habits and body image as well as motivational forces for change. Methods: A qualitative approach was chosen in order to gain insight into how morbidly obese adults experience everyday life. Qualitative interviews are well suited to provide insight into themes from the interviewee's life story from the subjects’ own perspectives. To gain insight into such processes, a narrative approach that allowed the informants to give voice to their ways of doing, thinking and feeling in daily life, was adopted. The informants comprised seven women and four men aged of 26–56 years, recruited from a population of obese individuals who had participated in a weight reduction course. A hermeneutic approach was used where the research question was the basis for a reflective interpretation. Results: The following meaning-units were identified: to be perceived as overweight; and to see oneself as overweight. Ingrained habits: the struggle between knowing and doing; acting without knowing; and eating is soothing. Conclusions: Seeing oneself as an obese person is a gradual process that implied experiencing oneself as different from significant others, such as (slim siblings and friends. To experience a gap between knowing and doing concerning food habits in everyday life indicates that informants value they have a choice. This is an important insight to consider when framing interventions to support this vulnerable group.

Multi-physics modeling and numerical simulation of weld pool in GTA welding

International Nuclear Information System (INIS)

Nguyen, Minh-Chien

2015-01-01

In this work, we develop a 3D physical and numerical model of the GTA (Gas Tungsten Arc) welding process in order to predict, for given welding parameters, useful quantities for the designer of welded assembly: weld bead shape, fluid flow in the weld pool as well as thermal distribution in the work piece. The model is developed in the Cast3M (http://www-cast3m.cea.fr/) finite element software and takes into account the main physical phenomena acting in the work piece and particularly in the weld pool, subject to source terms modeling the arc part of the welding process. A steady solution of this model is thought for and involves the coupling of the nonlinear thermohydraulics and electromagnetic equations together with the displacement of the deformable free surface of the weld pool. A first step in the development consisted in modeling the electromagnetic phenomena with two different numerical methods, in comparing the numerical results obtained with those of the literature and in quantifying the importance of the Lorentz force and the Joule effect compared to the other mechanical and thermal sources by computing power balances. Then, in order to assess the predictive capability of the model, simulations of various welding configurations are performed: variation in the chemical composition of the material, of the welding speed, of the prescribed arc pressure and of the welding positions, which is a focus of this work, are studied. A good agreement is obtained between the results of our model and other experimental and numerical results of the literature. Eventually, a model accounting for metal filling is proposed and its results are discussed. Thus, our complete model can be seen as a solid foundation towards future totally-coupled 3D welding models including the arc and it will be included in WPROCESS the in-house CEA software dedicated to the numerical simulation of welding. (author) [fr

Bioinstrumentation: Tools for Understanding Life.

Science.gov (United States)

Wandersee, James H., Ed.; And Others

This book was written to help introductory biology teachers gain a basic understanding of contemporary bioinstrumentation and the uses to which it is put in the laboratory. It includes topics that are most basic to understanding the nature of biology. The book is divided into five sections: (1) "Separation and Identification" that includes…

Toward Understanding How Early-Life Stress Reprograms Cognitive and Emotional Brain Networks.

Science.gov (United States)

Chen, Yuncai; Baram, Tallie Z

2016-01-01

methodologies. Because early-life adversity is a powerful determinant of subsequent vulnerabilities to emotional and cognitive pathologies, understanding the underlying processes will have profound implications for the world's current and future children.

Toward Understanding How Early-Life Stress Reprograms Cognitive and Emotional Brain Networks

Science.gov (United States)

Chen, Yuncai; Baram, Tallie Z

2016-01-01

methodologies. Because early-life adversity is a powerful determinant of subsequent vulnerabilities to emotional and cognitive pathologies, understanding the underlying processes will have profound implications for the world's current and future children. PMID:26105143

Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

DEFF Research Database (Denmark)

Scheel, Troels K H; Rice, Charles M

2013-01-01

More than two decades of intense research has provided a detailed understanding of hepatitis C virus (HCV), which chronically infects 2% of the world's population. This effort has paved the way for the development of antiviral compounds to spare patients from life-threatening liver disease......, such as HCV diversity, viral resistance, the influence of host genetics, advanced liver disease and other co-morbidities....

Understanding determinants of nutrition, physical activity and quality of life among older adults: the Wellbeing, Eating and Exercise for a Long Life (WELL study

Directory of Open Access Journals (Sweden)

McNaughton Sarah A

2012-09-01

Full Text Available Abstract Background Nutrition and physical activity are major determinants of health and quality of life; however, there exists little research focusing on determinants of these behaviours in older adults. This is important, since just as these behaviours vary according to subpopulation, it is likely that the determinants also vary. An understanding of the modifiable determinants of nutrition and physical activity behaviours among older adults to take into account the specific life-stage context is required in order to develop effective interventions to promote health and well-being and prevent chronic disease and improve quality of life. Methods The aim of this work is to identify how intrapersonal, social and environmental factors influence nutrition and physical activity behaviours among older adults living in urban and rural areas. This study is a cohort study of adults aged 55-65 years across urban and rural Victoria, Australia. Participants completed questionnaires at baseline in 2010 and will complete follow-up questionnaires in 2012 and 2014. Self-report questionnaires will be used to assess outcomes such as food intake, physical activity and sedentary behaviours, anthropometry and quality of life. Explanatory variables include socioeconomic position, and measures of the three levels of influence on older adults’ nutrition and physical activity behaviours (intrapersonal, social and perceived environmental influences. Discussion Obesity and its determinant behaviours, physical inactivity and poor diet are major public health concerns and are significant determinants of the quality of life among the ageing population. There is a critical need for a better understanding of the determinants of nutrition and physical activity in this important target group. This research will provide evidence for the development of effective policies and programs to promote and support increased physical activity and healthy eating behaviours among older

Anaerobic fungi (phylum Neocallimastigomycota): advances in understanding their taxonomy, life cycle, ecology, role and biotechnological potential.

Science.gov (United States)

Gruninger, Robert J; Puniya, Anil K; Callaghan, Tony M; Edwards, Joan E; Youssef, Noha; Dagar, Sumit S; Fliegerova, Katerina; Griffith, Gareth W; Forster, Robert; Tsang, Adrian; McAllister, Tim; Elshahed, Mostafa S

2014-10-01

Anaerobic fungi (phylum Neocallimastigomycota) inhabit the gastrointestinal tract of mammalian herbivores, where they play an important role in the degradation of plant material. The Neocallimastigomycota represent the earliest diverging lineage of the zoosporic fungi; however, understanding of the relationships of the different taxa (both genera and species) within this phylum is in need of revision. Issues exist with the current approaches used for their identification and classification, and recent evidence suggests the presence of several novel taxa (potential candidate genera) that remain to be characterised. The life cycle and role of anaerobic fungi has been well characterised in the rumen, but not elsewhere in the ruminant alimentary tract. Greater understanding of the 'resistant' phase(s) of their life cycle is needed, as is study of their role and significance in other herbivores. Biotechnological application of anaerobic fungi, and their highly active cellulolytic and hemi-cellulolytic enzymes, has been a rapidly increasing area of research and development in the last decade. The move towards understanding of anaerobic fungi using -omics based (genomic, transcriptomic and proteomic) approaches is starting to yield valuable insights into the unique cellular processes, evolutionary history, metabolic capabilities and adaptations that exist within the Neocallimastigomycota. © 2014 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.

Understanding the gut microbiome of dairy calves: Opportunities to improve early-life gut health.

Science.gov (United States)

Malmuthuge, Nilusha; Guan, Le Luo

2017-07-01

Early gut microbiota plays a vital role in the long-term health of the host. However, understanding of these microbiota is very limited in livestock species, especially in dairy calves. Neonatal calves are highly susceptible to enteric infections, one of the major causes of calf death, so approaches to improving gut health and overall calf health are needed. An increasing number of studies are exploring the microbial composition of the gut, the mucosal immune system, and early dietary interventions to improve the health of dairy calves, revealing possibilities for effectively reducing the susceptibility of calves to enteric infections while promoting growth. Still, comprehensive understanding of the effect of dietary interventions on gut microbiota-one of the key aspects of gut health-is lacking. Such knowledge may provide in-depth understanding of the mechanisms behind functional changes in response to dietary interventions. Understanding of host-microbial interactions with dietary interventions and the role of the gut microbiota during pathogenesis at the site of infection in early life is vital for designing effective tools and techniques to improve calf gut health. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Korean Survivors of the Japanese "Comfort Women" System: Understanding the Lifelong Consequences of Early Life Trauma.

Science.gov (United States)

Park, Jee Hoon; Lee, KyongWeon; Hand, Michelle D; Anderson, Keith A; Schleitwiler, Tess E

2016-01-01

Prior to and during World War II, thousands of girls and young women were abducted from Korea and forced into sexual slavery by the Japanese government. Termed comfort women, these girls and young women suffered extreme sexual, physical, and emotional abuse and trauma. Research on this group is not well-developed and people know little of the impact of this early life trauma on the lives of these women who are now in later life. Using snowball sampling, 16 older adult survivors of the comfort women system participated in semistructured qualitative interviews. Thematic analysis was conducted to gain an understanding of the trauma that these women suffered and how it impacted their lives. Results revealed the depths of the abuse these women suffered, including repeated rapes, physical beatings, humiliation, forced surgery and sterilization, and social exclusion. These early traumatic experiences appeared to reverberate throughout their lives in their family relations, their inability to marry and to conceive children, and their emotional and physical well-being throughout the life course and into later life. The experiences of these survivors illustrate the lasting impact of early-life trauma and can guide interventions with current survivors of sexual abuse or trafficking.

Schizophrenia, Narrative, and Neurocognition: The Utility of Life-Stories in Understanding Social Problem-Solving Skills.

Science.gov (United States)

Moe, Aubrey M; Breitborde, Nicholas J K; Bourassa, Kyle J; Gallagher, Colin J; Shakeel, Mohammed K; Docherty, Nancy M

2018-01-22

Schizophrenia researchers have focused on phenomenological aspects of the disorder to better understand its underlying nature. In particular, development of personal narratives-that is, the complexity with which people form, organize, and articulate their "life stories"-has recently been investigated in individuals with schizophrenia. However, less is known about how aspects of narrative relate to indicators of neurocognitive and social functioning. The objective of the present study was to investigate the association of linguistic complexity of life-story narratives to measures of cognitive and social problem-solving abilities among people with schizophrenia. Thirty-two individuals with a diagnosis of schizophrenia completed a research battery consisting of clinical interviews, a life-story narrative, neurocognitive testing, and a measure assessing multiple aspects of social problem solving. Narrative interviews were assessed for linguistic complexity using computerized technology. The results indicate differential relationships of linguistic complexity and neurocognition to domains of social problem-solving skills. More specifically, although neurocognition predicted how well one could both describe and enact a solution to a social problem, linguistic complexity alone was associated with accurately recognizing that a social problem had occurred. In addition, linguistic complexity appears to be a cognitive factor that is discernible from other broader measures of neurocognition. Linguistic complexity may be more relevant in understanding earlier steps of the social problem-solving process than more traditional, broad measures of cognition, and thus is relevant in conceptualizing treatment targets. These findings also support the relevance of developing narrative-focused psychotherapies. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Literature as a Key to Understanding People, Society and Life

Directory of Open Access Journals (Sweden)

Janani Ramanathan

2018-05-01

goes beyond a study of the individual and the society. It is pervaded with a deeper knowledge of the character of life itself. Some or perhaps all of these great truths were known to the ancients but forgotten or rejected by the modern mind so preoccupied with the external appearances of things. But Austen has consciously or subconsciously exquisitely captured many of these truths of life with the apparent effortlessness of a true master. Do our words come true? Can our thoughts and attitudes determine the events in our lives? What is the science behind coincidence? Is there such a thing as chance? Through Pride and Prejudice, Austen gives us the answers and illustrates the precise laws according to which life works. She even possesses insights into life missed by the renowned Shakespearean critic A.C. Bradley. Literature entertains and educates us. It can teach us about the past, help us understand the present and empower us to create the future. Read with this insight, Pride and Prejudice, as all great works of literature, offers us all the knowledge required to promote individual accomplishment and human welfare. New canons of literary criticism need to be evolved that discover the knowledge of life in literature.

The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome.

Science.gov (United States)

Daskalakis, Nikolaos P; Bagot, Rosemary C; Parker, Karen J; Vinkers, Christiaan H; de Kloet, E R

2013-09-01

Stressful experiences during early-life can modulate the genetic programming of specific brain circuits underlying emotional and cognitive aspects of behavioral adaptation to stressful experiences later in life. Although this programming effect exerted by experience-related factors is an important determinant of mental health, its outcome depends on cognitive inputs and hence the valence an individual assigns to a given environmental context. From this perspective we will highlight, with studies in rodents, non-human primates and humans, the three-hit concept of vulnerability and resilience to stress-related mental disorders, which is based on gene-environment interactions during critical phases of perinatal and juvenile brain development. The three-hit (i.e., hit-1: genetic predisposition, hit-2: early-life environment, and hit-3: later-life environment) concept accommodates the cumulative stress hypothesis stating that in a given context vulnerability is enhanced when failure to cope with adversity accumulates. Alternatively, the concept also points to the individual's predictive adaptive capacity, which underlies the stress inoculation and match/mismatch hypotheses. The latter hypotheses propose that the experience of relatively mild early-life adversity prepares for the future and promotes resilience to similar challenges in later-life; when a mismatch occurs between early and later-life experience, coping is compromised and vulnerability is enhanced. The three-hit concept is fundamental for understanding how individuals can either be prepared for coping with life to come and remain resilient or are unable to do so and succumb to a stress-related mental disorder, under seemingly identical circumstances. Copyright © 2013 Elsevier Ltd. All rights reserved.

Modeling Sources of Teaching Self-Efficacy for Science, Technology, Engineering, and Mathematics Graduate Teaching Assistants.

Science.gov (United States)

DeChenne, Sue Ellen; Koziol, Natalie; Needham, Mark; Enochs, Larry

2015-01-01

Graduate teaching assistants (GTAs) in science, technology, engineering, and mathematics (STEM) have a large impact on undergraduate instruction but are often poorly prepared to teach. Teaching self-efficacy, an instructor's belief in his or her ability to teach specific student populations a specific subject, is an important predictor of teaching skill and student achievement. A model of sources of teaching self-efficacy is developed from the GTA literature. This model indicates that teaching experience, departmental teaching climate (including peer and supervisor relationships), and GTA professional development (PD) can act as sources of teaching self-efficacy. The model is pilot tested with 128 GTAs from nine different STEM departments at a midsized research university. Structural equation modeling reveals that K-12 teaching experience, hours and perceived quality of GTA PD, and perception of the departmental facilitating environment are significant factors that explain 32% of the variance in the teaching self-efficacy of STEM GTAs. This model highlights the important contributions of the departmental environment and GTA PD in the development of teaching self-efficacy for STEM GTAs. © 2015 S. E. DeChenne et al. CBE—Life Sciences Education © 2015 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Metabonomics of ageing - Towards understanding metabolism of a long and healthy life.

Science.gov (United States)

Martin, Francois-Pierre J; Montoliu, Ivan; Kussmann, Martin

2017-07-01

Systems biology approaches have been increasingly employed in clinical studies to enhance our understanding of the role of genetics, environmental factors and their interactions on nutritional, health and disease status. Amongst the new omics technologies, metabonomics has emerged as a robust platform to capture metabolic and nutritional requirements by enabling, in a minimally invasive fashion, the monitoring of a wide range of biochemical compounds. Their variations reflect comprehensively the various molecular regulatory processes, which are tightly controlled and under the influence of genetics, diet, gut microbiota and other environmental factors. They are providing key insights into complex metabolic phenomena as well as into differences and specificities at individual and population level. The aim of this review is to evaluate promising metabolic insights towards understanding metabolism of a long and healthy life from pre-clinical and clinical metabonomics studies. We will also discuss analytical approaches to enable data integration, with an emphasis on the longitudinal component. Herein, we will illustrate current examples, challenges and perspectives in the applications of metabonomics monitoring and modelling approaches in the context of healthy ageing research. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

The SOS Response Master Regulator LexA Regulates the Gene Transfer Agent of Rhodobacter capsulatus and Represses Transcription of the Signal Transduction Protein CckA.

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Kuchinski, Kevin S; Brimacombe, Cedric A; Westbye, Alexander B; Ding, Hao; Beatty, J Thomas

2016-02-01

The gene transfer agent of Rhodobacter capsulatus (RcGTA) is a genetic exchange element that combines central aspects of bacteriophage-mediated transduction and natural transformation. RcGTA particles resemble a small double-stranded DNA bacteriophage, package random ∼4-kb fragments of the producing cell genome, and are released from a subpopulation (SOS response in many bacteria, as a regulator of RcGTA activity. Deletion of the lexA gene resulted in the abolition of detectable RcGTA production and an ∼10-fold reduction in recipient capability. A search for SOS box sequences in the R. capsulatus genome sequence identified a number of putative binding sites located 5' of typical SOS response coding sequences and also 5' of the RcGTA regulatory gene cckA, which encodes a hybrid histidine kinase homolog. Expression of cckA was increased >5-fold in the lexA mutant, and a lexA cckA double mutant was found to have the same phenotype as a ΔcckA single mutant in terms of RcGTA production. The data indicate that LexA is required for RcGTA production and maximal recipient capability and that the RcGTA-deficient phenotype of the lexA mutant is largely due to the overexpression of cckA. This work describes an unusual phenotype of a lexA mutant of the alphaproteobacterium Rhodobacter capsulatus in respect to the phage transduction-like genetic exchange carried out by the R. capsulatus gene transfer agent (RcGTA). Instead of the expected SOS response characteristic of prophage induction, this lexA mutation not only abolishes the production of RcGTA particles but also impairs the ability of cells to receive RcGTA-borne genes. The data show that, despite an apparent evolutionary relationship to lambdoid phages, the regulation of RcGTA gene expression differs radically. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Understanding health through social practices: performance and materiality in everyday life.

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Maller, Cecily Jane

2015-01-01

The importance of recognising structure and agency in health research to move beyond methodological individualism is well documented. To progress incorporating social theory into health, researchers have used Giddens' and Bourdieu's conceptualisations of social practice to understand relationships between agency, structure and health. However, social practice theories have more to offer than has currently been capitalised upon. This article delves into contemporary theories of social practice as used in consumption and sustainability research to provide an alternative, and more contextualised means, of understanding and explaining human action in relation to health and wellbeing. Two key observations are made. Firstly, the latest formulations of social practice theory distinguish moments of practice performance from practices as persistent entities across time and space, allowing empirical application to explain practice histories and future trajectories. Secondly, they emphasise the materiality of everyday life, foregrounding things, technologies and other non-humans that cannot be ignored in a technologically dependent social world. In concluding, I argue the value of using contemporary social practice theories in health research is that they reframe the way in which health outcomes can be understood and could inform more effective interventions that move beyond attitudes, behaviour and choices. © 2015 The Authors. Sociology of Health & Illness © 2015 Foundation for the Sociology of Health & Illness/John Wiley & Sons Ltd.

Impact of Hearing Aid Technology on Outcomes in Daily Life II: Speech Understanding and Listening Effort.

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Johnson, Jani A; Xu, Jingjing; Cox, Robyn M

2016-01-01

Modern hearing aid (HA) devices include a collection of acoustic signal-processing features designed to improve listening outcomes in a variety of daily auditory environments. Manufacturers market these features at successive levels of technological sophistication. The features included in costlier premium hearing devices are designed to result in further improvements to daily listening outcomes compared with the features included in basic hearing devices. However, independent research has not substantiated such improvements. This research was designed to explore differences in speech-understanding and listening-effort outcomes for older adults using premium-feature and basic-feature HAs in their daily lives. For this participant-blinded, repeated, crossover trial 45 older adults (mean age 70.3 years) with mild-to-moderate sensorineural hearing loss wore each of four pairs of bilaterally fitted HAs for 1 month. HAs were premium- and basic-feature devices from two major brands. After each 1-month trial, participants' speech-understanding and listening-effort outcomes were evaluated in the laboratory and in daily life. Three types of speech-understanding and listening-effort data were collected: measures of laboratory performance, responses to standardized self-report questionnaires, and participant diary entries about daily communication. The only statistically significant superiority for the premium-feature HAs occurred for listening effort in the loud laboratory condition and was demonstrated for only one of the tested brands. The predominant complaint of older adults with mild-to-moderate hearing impairment is difficulty understanding speech in various settings. The combined results of all the outcome measures used in this research suggest that, when fitted using scientifically based practices, both premium- and basic-feature HAs are capable of providing considerable, but essentially equivalent, improvements to speech understanding and listening effort in daily

Comparative Studies on Microstructure, Mechanical and Pitting Corrosion of Post Weld Heat Treated IN718 Superalloy GTA and EB Welds

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Dilkush; Mohammed, Raffi; Madhusudhan Reddy, G.; Srinivasa Rao, K.

2018-03-01

In the present study, an attempt has been made to weld Inconel 718 nickel-base superalloy (IN718 alloy) using gas tungsten arc welding (GTAW) and electron beam welding (EBW) processes. Both the weldments were subjected to post-weld heat treatment condition as follows -980°C / 20 min followed by direct aging condition (DA) as 720°C/8 h/FC followed by 620°C/8 h/AC. The GTA and EB welds of IN718 alloy were compared in two conditions as-received and 980STA conditions. Welds were characterized to observe mechanical properties, pitting corrosion resistance by correlating with observed microstructures. The rate of higher cooling ranges, the fusion zone of EBW exhibited discrete and relative finer lave phases whereas the higher niobium existed laves with coarser structure were observed in GTAW. The significant dissolution of laves were observed at 980STA of EBW. Due to these effects, the EBW of IN718 alloy showed the higher mechanical properties than GTAW. The electrochemical potentiostatic etch test was carried out in 3.5wt% sodium chloride (NaCl) solution to study the pitting corrosion behaviour of the welds. Results of the present investigation established that mechanical properties and pitting corrosion behaviour are significantly better in post weld heat treated condition. The comparative studies showed that the better combination of mechanical properties and pitting corrosion resistance were obtained in 980STA condition of EBW than GTAW.

Quality of Life Philosophy III. Towards a New Biology: Understanding the Biological Connection between Quality of Life, Disease, and Healing

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Soren Ventegodt

2003-01-01

Full Text Available This paper addresses (in a philosophical way the complex and enigmatic interface between matter, life, and consciousness in modern medical science. The problem today in understanding living matter is not at the molecular level, but at the macro level where all molecular activities in the individual cell are coordinated, and especially at a higher level, where the activities of all the organism’s cells are coordinated. Although we understand very much of the body’s chemistry, we have only just started to get the gist of the tremendous organization of living matter. We are just beginning to acknowledge the enormous flow of information that is needed to make everything function in a healthy organism, including consciousness, where every cell does exactly what it has to do to make the organs function.A concept that seems to be able to bridge the scientifically very different domains of matter, life, and consciousness seems to be “biological information”. If a cell is seen as a liquid crystal in which the cell’s molecules constantly connect in firm mutual relationships only to dissolve again and become fluid and free, whenever the cell needs it, the backbone of the cell seems to be the information that organizes the cell. For example, in cell motion a cell is able to crawl with the help of a skeleton of fibers that can be created guided by biological information, whenever the cell needs the solidity provided by the fibers. The moment it has finished crawling or intends to crawl in another direction, these fibers will dissolve again. The fibers are made of millions of molecules that connect in an arranged pattern, and they dissolve when these molecules again let go of each other. How the cell precisely regulates such processes is today a complete mystery. How cells cocreate consciousness is also an enigma. All we can do is describe the cell and the organisms arising from its cells as filled with energy and information as well as an

Munazza's story: Understanding science teaching and conceptions of the nature of science in Pakistan through a life history study

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Halai, Nelofer

In this study I have described and tried to comprehend how a female science teacher understands her practice. Additionally, I have developed some understanding of her understanding of the nature of science. While teaching science, a teacher projects messages about the nature of science that can be captured by observations and interviews. Furthermore, the manner is which a teacher conceptualizes science for teaching, at least in part, depends on personal life experiences. Hence, I have used the life history method to understand Munazza's practice. Munazza is a young female science teacher working in a private, co-educational school for children from middle income families in Karachi, Pakistan. Her stories are central to the study, and I have represented them using a number of narrative devices. I have woven in my own stories too, to illustrate my perspective as a researcher. The data includes 13 life history interviews and many informal conversations with Munazza, observations of science teaching in classes seven and eight, and interviews with other science teachers and administrative staff of the school. Munazza's personal biography and experiences of school and undergraduate courses has influenced the way she teaches. It has also influenced the way she does not teach. She was not inspired by her science teachers, so she has tried not to teach the way she was taught science. Contextual factors, her conception of preparation for teaching as preparation for subject content and the tension that she faces in balancing care and control in her classroom are some factors that influence her teaching. Munazza believes that science is a stable, superior and value-free way of knowing. In trying to understand the natural world, observations come first, which give reliable information about the world leading inductively to a "theory". Hence, she relies a great deal on demonstrations in the class where students "see" for themselves and abstract the scientific concept from the

Long will they live, work and learn : A scheme for understanding and influencing employability during the life span

NARCIS (Netherlands)

Nauta, Aukje; de Lange, Annet H.; Gortz, Saskia

2010-01-01

Long will they live, work and learn. A scheme for understanding and influencing employability during the life span A. Nauta, A. H. de Lange en S. Gortz, Gedrag & Organisatie, volume 23, June 2010, nr. 2, pp. 136-157 To stimulate employees' employability until high age, knowledge is needed about what

Early Understanding of the Concept of Living Things: An Examination of Young Children's Drawings of Plant Life

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Villarroel, José Domingo; Infante, Guillermo

2014-01-01

This paper looks at the drawings of a sample of 118 children aged between 4 and 7 years old on the topic of plant life and relates the content to their knowledge of the concept of living things. The research project uses two types of tests: a task to analyse the level of understanding of the concept of living things and a free drawing activity.…

Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma.

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Tsen, Andrew R; Long, Patrick M; Driscoll, Heather E; Davies, Matthew T; Teasdale, Benjamin A; Penar, Paul L; Pendlebury, William W; Spees, Jeffrey L; Lawler, Sean E; Viapiano, Mariano S; Jaworski, Diane M

2014-03-15

Cancer is associated with epigenetic (i.e., histone hypoacetylation) and metabolic (i.e., aerobic glycolysis) alterations. Levels of N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acetate, are reduced in glioma; yet, few studies have investigated acetate as a potential therapeutic agent. This preclinical study sought to test the efficacy of the food additive Triacetin (glyceryl triacetate, GTA) as a novel therapy to increase acetate bioavailability in glioma cells. The growth-inhibitory effects of GTA, compared to the histone deacetylase inhibitor Vorinostat (SAHA), were assessed in established human glioma cell lines (HOG and Hs683 oligodendroglioma, U87 and U251 glioblastoma) and primary tumor-derived glioma stem-like cells (GSCs), relative to an oligodendrocyte progenitor line (Oli-Neu), normal astrocytes, and neural stem cells (NSCs) in vitro. GTA was also tested as a chemotherapeutic adjuvant with temozolomide (TMZ) in orthotopically grafted GSCs. GTA-induced cytostatic growth arrest in vitro comparable to Vorinostat, but, unlike Vorinostat, GTA did not alter astrocyte growth and promoted NSC expansion. GTA alone increased survival of mice engrafted with glioblastoma GSCs and potentiated TMZ to extend survival longer than TMZ alone. GTA was most effective on GSCs with a mesenchymal cell phenotype. Given that GTA has been chronically administered safely to infants with Canavan disease, a leukodystrophy due to ASPA mutation, GTA-mediated acetate supplementation may provide a novel, safe chemotherapeutic adjuvant to reduce the growth of glioma tumors, most notably the more rapidly proliferating, glycolytic and hypoacetylated mesenchymal glioma tumors. © 2013 UICC.

Understanding political development through an intersectionality framework: Life stories of disability activists

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Akemi Nishida

2016-05-01

Full Text Available This article explores how those who do not share their marginalized identities with their surrounding people (e.g., family members and thus community resources relating to these identities, initiate and experience political development. The concept of intersectionality is used as an analytical tool to examine how one's political development is mediated via one's intersecting identities, communities, and experience of social in/justices. Life story interviews were conducted with disabled activists to explore this question. The stories reveal how these activists, who had initially resisted identifying as disabled for various reasons, eventually used the politicizing experiences from nondisability identities and communities to reframe and reclaim their disability status. By tracing the political developments of disabled people, this article places importance on understanding the process in a holistic way and on developing activist communities and movements that acknowledge intersecting identities and in/justices.

Understanding retirement: the promise of life-span developmental frameworks.

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Löckenhoff, Corinna E

2012-09-01

The impending retirement of large population cohorts creates a pressing need for practical interventions to optimize outcomes at the individual and societal level. This necessitates comprehensive theoretical models that acknowledge the multi-layered nature of the retirement process and shed light on the dynamic mechanisms that drive longitudinal patterns of adjustment. The present commentary highlights ways in which contemporary life-span developmental frameworks can inform retirement research, drawing on the specific examples of Bronfenbrenner's Ecological Model, Baltes and Baltes Selective Optimization with Compensation Framework, Schulz and Heckhausen's Motivational Theory of Life-Span Development, and Carstensen's Socioemotional Selectivity Theory. Ultimately, a life-span developmental perspective on retirement offers not only new interpretations of known phenomena but may also help to identify novel directions for future research as well as promising pathways for interventions.

Understanding the life experience of people on hemodialysis: adherence to treatment and quality of life.

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Guerra-Guerrerro, Verónica; Plazas, Maria del Pilar Camargo; Cameron, Brenda L; Salas, Anna Valeria Santos; González, Carmen Gloria Cofre

2014-01-01

This hermeneutic-phenomenological study explores the lived experiences of patients on hemodialysis in regard to the adherence to treatment and quality of life. Fifteen patients were interviewed, including six women and nine men from three dialysis centers in Chile. Two main themes derived from the analysis: 1) embracing the disease and dialysis, and 2) preventing progression of the disease through treatment management. The findings suggest that patients recognize adherence to treatment and quality of life as conditions that derive from self-care and environmental conditions, which the healthcare provider must constantly assess for care planning to improve the adherence and quality of life in this population.

Understanding the life experiences of Brazilian women after bariatric surgery: a qualitative study.

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Magdaleno, Ronis; Chaim, Elinton Adami; Turato, Egberto Ribeiro

2010-08-01

The increase in bariatric surgeries has called into question the aspects that contribute to or impair the results. Psychosocial factors directly influence the results of the surgery, but a lot of controversy exists in relation to the degree of influence of these factors. We propose a qualitative investigation to understand the significance of the surgery for women and how these factors influence the outcomes. This study is a clinical-qualitative method, through the semi-directed interview with open-ended questions in an intentional sample, closed by saturation, with seven women operated in a period of 1.5-3 years, following the definition of emergent categories and qualitative content analysis. The experience of acceptance and social reinsertion is a motivating factor to keep up the challenge of weight loss; social discrimination is a risk factor leading to losing the stimulus to continue the process; the recuperation of self-esteem and personal identity is a factor that improves the quality of life and psychopathological symptoms; disillusionment is an important risk factor, linked principally to the experiences of failure. We observe the necessity of qualitative studies that serve the health team in the handling of these patients, aiming for a greater understanding of their psychological dynamics and of the meanings that weight loss has for them.

Lessons learned on the Ground Test Accelerator control system

International Nuclear Information System (INIS)

Kozubal, A.J.; Weiss, R.E.

1994-01-01

When we initiated the control system design for the Ground Test Accelerator (GTA), we envisioned a system that would be flexible enough to handle the changing requirements of an experimental project. This control system would use a developers' toolkit to reduce the cost and time to develop applications for GTA, and through the use of open standards, the system would accommodate unforeseen requirements as they arose. Furthermore, we would attempt to demonstrate on GTA a level of automation far beyond that achieved by existing accelerator control systems. How well did we achieve these goals? What were the stumbling blocks to deploying the control system, and what assumptions did we make about requirements that turned out to be incorrect? In this paper we look at the process of developing a control system that evolved into what is now the ''Experimental Physics and Industrial Control System'' (EPICS). Also, we assess the impact of this system on the GTA project, as well as the impact of GTA on EPICS. The lessons learned on GTA will be valuable for future projects

Mode of Communication, Perceived Level of Understanding, and Perceived Quality of Life in Youth Who Are Deaf or Hard of Hearing

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Kushalnagar, P.; Topolski, T. D.; Schick, B.; Edwards, T. C.; Skalicky, A. M.; Patrick, D. L.

2011-01-01

Given the important role of parent–youth communication in adolescent well-being and quality of life, we sought to examine the relationship between specific communication variables and youth perceived quality of life in general and as a deaf or hard-of-hearing (DHH) individual. A convenience sample of 230 youth (mean age = 14.1, standard deviation = 2.2; 24% used sign only, 40% speech only, and 36% sign + speech) was surveyed on communication-related issues, generic and DHH-specific quality of life, and depression symptoms. Higher youth perception of their ability to understand parents’ communication was significantly correlated with perceived quality of life as well as lower reported depressive symptoms and lower perceived stigma. Youth who use speech as their single mode of communication were more likely to report greater stigma associated with being DHH than youth who used both speech and sign. These findings demonstrate the importance of youths’ perceptions of communication with their parents on generic and DHH-specific youth quality of life. PMID:21536686

Understanding Latina/o Students' Meaning in Life, Spirituality, and Subjective Happiness

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Cavazos Vela, Javier; Castro, Veronica; Cavazos, Leticia; Cavazos, Michelle; Gonzalez, Stacey Lee

2015-01-01

One-hundred nineteen Latina/o college students provided perceptions of presence of meaning in life, search for meaning in life, daily spiritual experiences, and subjective happiness. Perceptions of meaning in life and daily spiritual experiences were significant predictors of subjective happiness. A discussion regarding the importance of these…

Human development II: We Need an Integrated Theory for Matter, Life and Consciousness to Understand Life and Healing

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Sören Ventegodt

2006-01-01

Full Text Available For almost a decade, we have experimented with supporting the philosophical development of severely ill patients to induce recovery and spontaneous healing. Recently, we have observed a new pattern of extremely rapid, spontaneous healing that apparently can facilitate even the spontaneous remission of cancer and the spontaneous recovery of mental diseases like schizophrenia and borderline schizophrenia. Our working hypothesis is that the accelerated healing is a function of the patient’s brain-mind and body-mind coming closer together due to the development of what we call “deep” cosmology. To understand and describe what happens at a biological level, we have suggested naming the process adult human metamorphosis, a possibility that is opened by the human genome showing full generic equipment for metamorphosis. To understand the mechanistic details in the complicated interaction between consciousness and biology, we need an adequate theory for biological information. In a series of papers, we propose what we call “holistic biology for holistic medicine”. We suggest that a relatively simple model based on interacting wholenesses instead of isolated parts can shed a new light on a number of difficult issues that we need to explain and understand in biology and medicine in order to understand and use metamorphosis in the holistic medical clinic. We aim to give a holistic theoretical interpretation of biological phenomena at large, morphogenesis, evolution, immune system regulation (self-nonself discrimination, brain function, consciousness, and health in particular. We start at the most fundamental problem: what is biological information at the subcellular, cellular, and supracellular levels if we presume that it is the same phenomenon on all levels (using Occam's razor, and how can this be described scientifically? The problems we address are all connected to the information flow in the functioning, living organism: function of the brain

Human development II: we need an integrated theory for matter, life and consciousness to understand life and healing.

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Ventegodt, Søren; Hermansen, Tyge Dahl; Nielsen, Maj Lyck; Clausen, Birgitte; Merrick, Joav

2006-07-06

For almost a decade, we have experimented with supporting the philosophical development of severely ill patients to induce recovery and spontaneous healing. Recently, we have observed a new pattern of extremely rapid, spontaneous healing that apparently can facilitate even the spontaneous remission of cancer and the spontaneous recovery of mental diseases like schizophrenia and borderline schizophrenia. Our working hypothesis is that the accelerated healing is a function of the patient's brain-mind and body-mind coming closer together due to the development of what we call "deep" cosmology. To understand and describe what happens at a biological level, we have suggested naming the process adult human metamorphosis, a possibility that is opened by the human genome showing full generic equipment for metamorphosis. To understand the mechanistic details in the complicated interaction between consciousness and biology, we need an adequate theory for biological information. In a series of papers, we propose what we call "holistic biology for holistic medicine". We suggest that a relatively simple model based on interacting wholenesses instead of isolated parts can shed a new light on a number of difficult issues that we need to explain and understand in biology and medicine in order to understand and use metamorphosis in the holistic medical clinic. We aim to give a holistic theoretical interpretation of biological phenomena at large, morphogenesis, evolution, immune system regulation (self-nonself discrimination), brain function, consciousness, and health in particular. We start at the most fundamental problem: what is biological information at the subcellular, cellular, and supracellular levels if we presume that it is the same phenomenon on all levels (using Occam's razor), and how can this be described scientifically? The problems we address are all connected to the information flow in the functioning, living organism: function of the brain and consciousness, the

Validity, reliability and understanding of the EORTC-C30 and EORTC-BR23, quality of life questionnaires specific for breast cancer

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Fernanda Alessandra Silva Michels

2013-06-01

Full Text Available Objective: To validate and assess reliability and understanding of the EORTC–C30 quality of life questionnaire and its breast cancer specific module, the EORTC-BR23. Methods: This study was conducted at the AC Camargo Cancer Hospital, São Paulo, Brazil. A total of 100 women diagnosed with breast cancer were interviewed. Internal consistency, confirmatory factorial analysis, convergent validity, construct validity and degree of understanding were examined. Reliability was assessed by comparison of means at times 1 and 2, inter-class coefficient and Bland-Altman graphics. Results: Cronbach’s alpha ranged from 0.72 to 0.86 for the EORTC-C30 and from 0.78 to 0.83 for the EORTC-BR23 questionnaire. Most questions were confirmed in the confirmatory factorial analysis. In the construct validity analysis, the questionnaires were capable of differentiating patients with or without lymphedema, apart from the symptom scales of both questionnaires. Both questionnaires presented a significant correlation in most domains of the SF-36, in the convergent validity analysis. Only a few criticisms were reported concerning questions, and the mean grade of understanding was high (C30 = 4.91 and BR23 = 4.89. The questionnaires presented good rates of reliability, with the exception of the functional scale of the C30 and the symptom scale of the BR23. Conclusions: The EORTC-C30 and EORTC-BR23 quality of life questionnaires were validated, presented good rates of reliability and are easily understood, allowing them to be used in Brazil to assess quality of life among women with breast cancer.

Understanding the contribution of suicide to life expectancy in South Korea

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Aggie Noah

2016-09-01

Full Text Available Background: South Korea has the highest rate and highest rate of increase in suicide among developed countries. The suicide epidemic in Korea is an anomaly, and suicide rates are high for both men and women, with no signs of decreasing. Yet we do not know the extent to which suicide has reduced life expectancy in Korea. Objective: We investigated whether and to what extent the rapid increase in suicide has contributed to changes in Korean life expectancy, a key indicator of population health. Methods: We used a recently developed decomposition method that separates the contribution of suicide's effect on change in life expectancy into two parts: that due to change in the overall suicide incidence rate and that due to change in the mean age of suicide victims. Results: From 1995 to 2010, life expectancy increased by 6.5 years in Korea, with change in most causes of death contributing to its growth. We nonetheless find, as expected, that the rise in suicides reduced the increase in life expectancy from 1995 to 2010, so life expectancy in Korea is about 0.21 years lower than it would have been without the increase in suicides. Moreover, had the age of suicide victims remained stable, we project that Korea's life expectancy would be fully 0.70 years lower than it is. Conclusions: Although the growth in suicide was the largest single factor slowing the rise in Korean life expectancy, the effect would have been even larger had the age of suicide victims not increased.

Health Care Professionals' Understandings of Cross-Cultural Interaction in End-of-Life Care: A Focus Group Study.

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Milberg, Anna; Torres, Sandra; Ågård, Pernilla

2016-01-01

The academic debate on cross-cultural interaction within the context of end-of-life care takes for granted that this interaction is challenging. However, few empirical studies have actually focused on what health care professionals think about this interaction. This study aimed to explore health care professionals' understandings of cross-cultural interaction during end-of-life care. Sixty end-of-life care professionals were recruited from eleven care units in Sweden to take part in focus group interviews. These interviews were analyzed using qualitative content analysis. The health care professionals interviewed talked about cross-cultural interaction in end-of-life care as interaction that brings about uncertainty, stress and frustration even though they had limited experience of this type of interaction. The focus group discussions brought attention to four specific challenges that they expected to meet when they care for patients with migrant backgrounds since they took for granted that they would have an ethno-cultural background that is different to their own. These challenges had to do with communication barriers, 'unusual' emotional and pain expressions, the expectation that these patients' families would be 'different' and the anticipation that these patients and their families lack knowledge. At the core of the challenges in question is the idea that cross-cultural interaction means meeting "the unknown". In addition, the end-of-life care professionals interviewed talked about patients whose backgrounds they did not share in homogenizing terms. It is against this backdrop that they worried about their ability to provide end-of-life care that is individualized enough to meet the needs of these patients. The study suggests that end-of-life care professionals who regard cross-cultural interaction in this manner could face actual challenges when caring for patients whose backgrounds they regard as "the unknown" since they anticipate a variety of challenges

Health Care Professionals’ Understandings of Cross-Cultural Interaction in End-of-Life Care: A Focus Group Study

Science.gov (United States)

Torres, Sandra; Ågård, Pernilla

2016-01-01

Objective The academic debate on cross-cultural interaction within the context of end-of-life care takes for granted that this interaction is challenging. However, few empirical studies have actually focused on what health care professionals think about this interaction. This study aimed to explore health care professionals’ understandings of cross-cultural interaction during end-of-life care. Methods Sixty end-of-life care professionals were recruited from eleven care units in Sweden to take part in focus group interviews. These interviews were analyzed using qualitative content analysis. Results The health care professionals interviewed talked about cross-cultural interaction in end-of-life care as interaction that brings about uncertainty, stress and frustration even though they had limited experience of this type of interaction. The focus group discussions brought attention to four specific challenges that they expected to meet when they care for patients with migrant backgrounds since they took for granted that they would have an ethno-cultural background that is different to their own. These challenges had to do with communication barriers, ‘unusual’ emotional and pain expressions, the expectation that these patients’ families would be ‘different’ and the anticipation that these patients and their families lack knowledge. At the core of the challenges in question is the idea that cross-cultural interaction means meeting “the unknown”. In addition, the end-of-life care professionals interviewed talked about patients whose backgrounds they did not share in homogenizing terms. It is against this backdrop that they worried about their ability to provide end-of-life care that is individualized enough to meet the needs of these patients. Conclusions The study suggests that end-of-life care professionals who regard cross-cultural interaction in this manner could face actual challenges when caring for patients whose backgrounds they regard as �

Health Care Professionals' Understandings of Cross-Cultural Interaction in End-of-Life Care: A Focus Group Study.

Directory of Open Access Journals (Sweden)

Anna Milberg

Full Text Available The academic debate on cross-cultural interaction within the context of end-of-life care takes for granted that this interaction is challenging. However, few empirical studies have actually focused on what health care professionals think about this interaction. This study aimed to explore health care professionals' understandings of cross-cultural interaction during end-of-life care.Sixty end-of-life care professionals were recruited from eleven care units in Sweden to take part in focus group interviews. These interviews were analyzed using qualitative content analysis.The health care professionals interviewed talked about cross-cultural interaction in end-of-life care as interaction that brings about uncertainty, stress and frustration even though they had limited experience of this type of interaction. The focus group discussions brought attention to four specific challenges that they expected to meet when they care for patients with migrant backgrounds since they took for granted that they would have an ethno-cultural background that is different to their own. These challenges had to do with communication barriers, 'unusual' emotional and pain expressions, the expectation that these patients' families would be 'different' and the anticipation that these patients and their families lack knowledge. At the core of the challenges in question is the idea that cross-cultural interaction means meeting "the unknown". In addition, the end-of-life care professionals interviewed talked about patients whose backgrounds they did not share in homogenizing terms. It is against this backdrop that they worried about their ability to provide end-of-life care that is individualized enough to meet the needs of these patients.The study suggests that end-of-life care professionals who regard cross-cultural interaction in this manner could face actual challenges when caring for patients whose backgrounds they regard as "the unknown" since they anticipate a variety

A gene transfer agent and a dynamic repertoire of secretion systems hold the keys to the explosive radiation of the emerging pathogen Bartonella.

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Lionel Guy

2013-03-01

Full Text Available Gene transfer agents (GTAs randomly transfer short fragments of a bacterial genome. A novel putative GTA was recently discovered in the mouse-infecting bacterium Bartonella grahamii. Although GTAs are widespread in phylogenetically diverse bacteria, their role in evolution is largely unknown. Here, we present a comparative analysis of 16 Bartonella genomes ranging from 1.4 to 2.6 Mb in size, including six novel genomes from Bartonella isolated from a cow, two moose, two dogs, and a kangaroo. A phylogenetic tree inferred from 428 orthologous core genes indicates that the deadly human pathogen B. bacilliformis is related to the ruminant-adapted clade, rather than being the earliest diverging species in the genus as previously thought. A gene flux analysis identified 12 genes for a GTA and a phage-derived origin of replication as the most conserved innovations. These are located in a region of a few hundred kb that also contains 8 insertions of gene clusters for type III, IV, and V secretion systems, and genes for putatively secreted molecules such as cholera-like toxins. The phylogenies indicate a recent transfer of seven genes in the virB gene cluster for a type IV secretion system from a cat-adapted B. henselae to a dog-adapted B. vinsonii strain. We show that the B. henselae GTA is functional and can transfer genes in vitro. We suggest that the maintenance of the GTA is driven by selection to increase the likelihood of horizontal gene transfer and argue that this process is beneficial at the population level, by facilitating adaptive evolution of the host-adaptation systems and thereby expansion of the host range size. The process counters gene loss and forces all cells to contribute to the production of the GTA and the secreted molecules. The results advance our understanding of the role that GTAs play for the evolution of bacterial genomes.

Engineering Good: How Engineering Metaphors Help us to Understand the Moral Life and Change Society

Science.gov (United States)

2009-01-01

Engineering can learn from ethics, but ethics can also learn from engineering. In this paper, I discuss what engineering metaphors can teach us about practical philosophy. Using metaphors such as calculation, performance, and open source, I articulate two opposing views of morality and politics: one that relies on images related to engineering as science and one that draws on images of engineering practice. I argue that the latter view and its metaphors provide a more adequate way to understand and guide the moral life. Responding to two problems of alienation and taking into account developments such as Fab Lab I then further explore the implications of this view for engineering and society. PMID:19722107

Can understanding squid life-history strategies and recruitment ...

African Journals Online (AJOL)

Current views of the links between life-history strategies and recruitment processes in fish are contrasted with the pattern emerging for squid. A general perspective is that the roles of space and time are reversed in the two groups, suggesting that management strategies also should differ. The space/time reversal appears to ...

Mycobacterium massiliense BRA100 strain recovered from postsurgical infections: resistance to high concentrations of glutaraldehyde and alternative solutions for high level disinfection Mycobacterium massiliense clone BRA100 associado a infecções pós-cirúrgicas: resistência a altas concentrações de glutaraldeído e produtos alternativos para desinfecção de alto nível

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Nádia Suely de Oliveira Lorena

2010-10-01

Full Text Available PURPOSE: To evaluate the minimum inhibitory concentration (MIC of GTA against these microorganisms and alternative disinfectants for high-level disinfection (HLD. METHODS: Reference mycobacteria and clinical M. massiliense strains were included in this study. Active cultures were submitted to susceptibility qualitative tests with GTA dilutions (ranging from 1.5% to 8%, and commercial orthophthaldehyde (OPA and peracetic acid (PA - based solutions, during the period of exposure as recommended by National Agency of Sanitary Surveillance for HLD. RESULTS: All reference and M. massiliense non-BRA100 strains, recovered from sputum, were susceptible to any GTA concentration, OPA and PA solutions. M. massiliense BRA100 strains presented MIC of 8% GTA and were susceptible to OPA and PA. CONCLUSION: M. massiliense BRA100 strain is resistant to high GTA concentrations (up to 7%, which proves that this product is non-effective against specific rapidly growing mycobacteria and should be substituted by OPA or PA - based solutions for HLD.OBJETIVO: Avaliar a concentração mínima inibitória (CMI de GTA frente a M. massiliense e a susceptibilidade a produtos alternativos para desinfecção de alto nível (DAN. MÉTODOS: Cepas de M. massiliense de origem clínica e de referência foram incluídas no estudo. As culturas ativadas foram submetidas a testes qualitativos com diluições de GTA (de 1,5% a 8% e com soluções comerciais de ortoftaldeído (OPA ou ácido peracético (PA, utilizando os tempos de exposição recomendados pela Agência Nacional de Vigilância Sanitária para DAN. RESULTADOS: Todas as cepas de referência e M. massiliense não-BRA100, obtida de escarro, foram susceptíveis às concentrações de GTA, e soluções de OPA e PA. As cepas de M. massiliense BRA100 apresentaram CMI de 8% para GTA e foram susceptíveis a OPA e PA. CONCLUSÃO: M. massiliense BRA100 é resistente a altas concentrações de GTA (até 7%, o que demonstra que esse

Understanding Resilience

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Gang eWu

2013-02-01

Full Text Available Resilience is the ability to adapt successfully in the face of stress and adversity. Stressful life events, trauma and chronic adversity can have a substantial impact on brain function and structure, and can result in the development of PTSD, depression and other psychiatric disorders. However, most individuals do not develop such illnesses after experiencing stressful life events, and are thus thought to be resilient. Resilience as successful adaptation relies on effective responses to environmental challenges and ultimate resistance to the deleterious effects of stress, therefore a greater understanding of the factors that promote such effects is of great relevance. This review focuses on recent findings regarding genetic, epigenetic, developmental, psychosocial and neurochemical factors that are considered essential contributors to the development of resilience. Neural circuits and pathways involved in mediating resilience are also discussed. The growing understanding of resilience factors will hopefully lead to the development of new pharmacological and psychological interventions for enhancing resilience and mitigating the untoward consequences.

Wheels and Tires: Understanding the Numbers on the Sides of Tires Might Lead to Longer Life Tires and Improved Driving Safety

Science.gov (United States)

Ritz, John M.

2005-01-01

Automotive wheels and tires require knowledge to understand their specifications and use. While the durability and useful life of tires have increased substantially over the last several decades, in all probability consumers will purchase a number of vehicle tires over their lifetime. Knowing how they are made and what the numbers mean will assist…

A New Understanding of Quality of Life in Children and Adolescents with Obesity: Contribution of the Self-determination Theory.

Science.gov (United States)

Buttitta, Marie; Rousseau, Amélie; Guerrien, Alain

2017-12-01

Preservation of Quality of Life (QOL) is now a major determinant of obesity management, but little is known about variables predicting QOL. Identifying these predicting variables of QOL would provide further understanding of the QOL concept and help draw clinical implications. The Self-determination Theory (SDT) is a promising understanding perspective of the QOL. The SDT postulates that well-being and motivation are determined by the satisfaction of three needs: autonomy, competence, and relatedness. Many researches have confirmed the relationships between these SDT's needs and well-being, but this theory has little been applied to the problem of QOL in obese children and adolescents. Literature results and theoretical implications of the SDT in understanding of QOL in youth obesity are discussed. New clinical applications could be drawn: in children with obesity, interventions promoting high satisfaction of the SDT's needs could improve their QOL and help them break the vicious circles of overweight.

Understanding life together: A brief history of collaboration in biology

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Vermeulen, Niki; Parker, John N.; Penders, Bart

2013-01-01

The history of science shows a shift from single-investigator ‘little science’ to increasingly large, expensive, multinational, interdisciplinary and interdependent ‘big science’. In physics and allied fields this shift has been well documented, but the rise of collaboration in the life sciences and its effect on scientific work and knowledge has received little attention. Research in biology exhibits different historical trajectories and organisation of collaboration in field and laboratory – differences still visible in contemporary collaborations such as the Census of Marine Life and the Human Genome Project. We employ these case studies as strategic exemplars, supplemented with existing research on collaboration in biology, to expose the different motives, organisational forms and social dynamics underpinning contemporary large-scale collaborations in biology and their relations to historical patterns of collaboration in the life sciences. We find the interaction between research subject, research approach as well as research organisation influencing collaboration patterns and the work of scientists. PMID:23578694

Elder Abuse by Adult Children: An Applied Ecological Framework for Understanding Contextual Risk Factors and the Intergenerational Character of Quality of Life.

Science.gov (United States)

Schiamberg, Lawrence B.; Gans, Daphna

2000-01-01

Using an applied ecological model, this study focuses on contextual risk factors of elder abuse. Five levels of environment were used to interpret existing research on risk factors. Configuration of risk factors provides a framework for understanding the intergenerational character of quality of life for older adults, developing recommendations…

Understanding the role that Quality of Work Life of food and ...

African Journals Online (AJOL)

that food and beverage managers should try to improve the working .... employee's work life. Therefore, the Quality of Work Life of employees contributes to the satisfaction they experience, both from the workplace and from the work itself ...... strategic direction and the performance of the establishment, and finally, allowing.

Landslides in everyday life: An interdisciplinary approach to understanding vulnerability in the Himalayas

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Sudmeier-Rieux, K.; Breguet, A.; Dubois, J.; Jaboyedoff, M.

2009-04-01

Several thousand landslides were triggered by the Kashmir earthquake, scarring the hillside with cracks. Monsoon rains continue to trigger landslides, which have increased the exposure of populations because of lost agricultural lands, blocked roads and annual fatalities due to landslides. The great majority of these landslides are shallow and relatively small but greatly impacting the population. In this region, landslides were a factor before the earthquake, mainly due to road construction and gravel excavation, but the several thousand landslides triggered by the earthquake have completely overwhelmed the local population and authorities. In Eastern Nepal, the last large earthquake to hit this region occurred in 1988, also triggering numerous landslides and cracks. Here, landslides can be considered a more common phenomenon, yet coping capacities amount to local observations of landslide movement, subsequent abandonment of houses and land as they become too dangerous. We present a comparative case study from Kashmir, Pakistan and Eastern Nepal, highlighting an interdisciplinary approach to understanding the complex interactions between land use, landslides and vulnerability. Our approach sets out to understand underlying causes of the massive landslides triggered by the 2005 earthquake in Kashmir, Pakistan, and also the increasing number of landslides in Nepal. By approaching the issue of landslides from multiple angles (risk perceptions, land use, local coping capacities, geological assessment, risk mapping) and multiple research techniques (remote sensing, GIS, geological assessment, participatory mapping, focus groups) we are better able to create a more complete picture of the "hazardscape". We find that by combining participatory social science research with hazard mapping, we obtain a more complete understanding of underlying causes, coping strategies and possible mitigation options, placing natural hazards in the context of everyday life. This method is

Interculturalism and Physical Cultural Diversity in the Greater Toronto Area

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Yuka Nakamura

2017-06-01

Full Text Available The Greater Toronto Area (GTA is one of the most multicultural communities in the world. Frequently, this description is based on ethnic, linguistic, and culinary diversity. Physical cultural diversity, such as different sports, martial arts, forms of dance, exercise systems, and other physical games and activities, remains ignored and understudied. Based on a living database of the GTA’s physical cultural diversity, this study identifies the trajectories of the lifecycle of activities that have been introduced into the GTA’s physical culture by immigrants. These pathways differ based on whether the activity is offered in a separate setting, where individuals may be participating with other immigrants of the same ethnocultural group, or mixed settings, where people are participating with people from outside of their ethnocultural group. We argue that the diversity and the lifecycle trajectories of physical cultural forms in the GTA serve as evidence of interculturalism and the contribution by immigrants to the social and cultural life of Canada.

Understanding Quality of Life in Adults with Spinal Cord Injury Via SCI-Related Needs and Secondary Complications.

Science.gov (United States)

Sweet, Shane N; Noreau, Luc; Leblond, Jean; Dumont, Frédéric S

2014-01-01

Understanding the factors that can predict greater quality of life (QoL) is important for adults with spinal cord injury (SCI), given that they report lower levels of QoL than the general population. To build a conceptual model linking SCI-related needs, secondary complications, and QoL in adults with SCI. Prior to testing the conceptual model, we aimed to develop and evaluate the factor structure for both SCI-related needs and secondary complications. Individuals with a traumatic SCI (N = 1,137) responded to an online survey measuring 13 SCI-related needs, 13 secondary complications, and the Life Satisfaction Questionnaire to assess QoL. The SCI-related needs and secondary complications were conceptualized into factors, tested with a confirmatory factor analysis, and subsequently evaluated in a structural equation model to predict QoL. The confirmatory factor analysis supported a 2-factor model for SCI related needs, χ(2)(61, N = 1,137) = 250.40, P SCI-related needs (β = -.22 and -.20, P SCI-related needs of individuals with SCI and preventing or managing secondary complications are essential to their QoL.

The Quality of Working Life.

Science.gov (United States)

Burke, Ronald J.

1979-01-01

Defines the concept "quality of working life," why interest in this has increased, and why guidance counselors and students should understand it. Quality of working life means more than job satisfaction or flexible working hours. It helps guidance teachers understand attitudes and expectations of students embarking on their first job.…

Mobilizing the Forgotten Army: Improving Undergraduate Math and Science Education through Professional Development of Graduate Teaching Assistants

Science.gov (United States)

Gerton, Jordan

Evidence-based best practices for improving undergraduate STEM education abound. Unfortunately, these practices have not been widely adopted, in part because typical dissemination efforts are mediated in a top-down fashion and fail to obtain critical buy-in from key local stakeholders. Here, we present a novel framework to increase nationwide uptake of STEM-education best practices through grassroots propagation of Professional Development programs for Graduate Teaching Assistants (GTA-PD). Our model pays special attention to overcoming resistance to change by soliciting, from the very start, critical buy-in from departmental chairs, faculty, and GTAs who have direct control over and responsibility for instruction. A key component of our approach involves an annual National GTA Workshop where faculty-GTA leadership teams from many different Physics and Chemistry departments come together to develop best-practices-based GTA-PD improvement plans for their own departments while guided by a core group of nationally recognized expert practitioners in GTA-PD and STEM education. As a pre-condition for participation, each department chair must pledge to facilitate implementation of their leadership team's plan; additional and ongoing support is provided by the core group of experts, together with other teams from the workshop cohort. Our initial pilot efforts point to success via enthusiastic buy-in within each STEM department due to the potential for immediate positive impacts on both undergraduate instruction and the long term research productivity of GTAs. In the future, longitudinal data on the progress of the GTA-PD programs will be gathered and analyzed to provide guidance for improving the success of future GTA-PD programs. Financial support provided by the Research Corporation for Science Advancement and the American Chemical Society.

Understanding Life : The Evolutionary Dynamics of Complexity and Semiosis

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Loeckenhoff, Helmut K.

2010-11-01

Post-Renaissance sciences created different cultures. To establish an epistemological base, Physics were separated from the Mental domain. Consciousness was excluded from science. Life Sciences were left in between e.g. LaMettrie's `man—machine' (1748) and 'vitalism' [e.g. Bergson 4]. Causative thinking versus intuitive arguing limited strictly comprehensive concepts. First ethology established a potential shared base for science, proclaiming the `biology paradigm' in the middle of the 20th century. Initially procured by Cybernetics and Systems sciences, `constructivist' models prepared a new view on human perception and thus also of scientific `objectivity when introducing the `observer'. In sequel Computer sciences triggered the ICT revolution. In turn ICT helped to develop Chaos and Complexity sciences, Non-linear Mathematics and its spin-offs in the formal sciences [Spencer-Brown 49] as e.g. (proto-)logics. Models of life systems, as e.g. Anticipatory Systems, integrated epistemology with mathematics and Anticipatory Computing [Dubois 11, 12, 13, 14] connecting them with Semiotics. Seminal ideas laid in the turn of the 19th to the 20th century [J. v. Uexküll 53] detected the co-action and co-evolvement of environments and life systems. Bio-Semiotics ascribed purpose, intent and meaning as essential qualities of life. The concepts of Systems Biology and Qualitative Research enriched and develop also anthropologies and humanities. Brain research added models of (higher) consciousness. An avant-garde is contemplating a science including consciousness as one additional base. New insights from the extended qualitative approach led to re-conciliation of basic assumptions of scientific inquiry, creating the `epistemological turn'. Paradigmatically, resting on macro- micro- and recently on nano-biology, evolution biology sired fresh scripts of evolution [W. Wieser 60,61]. Its results tie to hypotheses describing the emergence of language, of the human mind and of

Effect of beam oscillation on borated stainless steel electron beam welds

Energy Technology Data Exchange (ETDEWEB)

RajaKumar, Guttikonda [Tagore Engineering College, Chennai (India). Dept. of Mechanical Engineering; Ram, G.D. Janaki [Indian Institute of Technology (IIT), Chennai (India). Dept. of Metallurgical and Materials Engineering; Rao, S.R. Koteswara [SSN College of Engineering, Chennai (India). Mechanical Engineering

2015-07-01

Borated stainless steels are used in nuclear power plants to control neutron criticality in reactors as control rods, shielding material, spent fuel storage racks and transportation casks. In this study, bead on plate welds were made using gas tungsten arc welding (GTAW) and electron beam welding (EBW) processes. Electron beam welds made using beam oscillation technique exhibited higher tensile strength values compared to that of GTA welds. Electron beam welds were found to show fine dendritic microstructure while GTA welds exhibited larger dendrites. While both processes produced defect free welds, GTA welds are marked by partially melted zone (PMZ) where the hardness is low. EBW obviate the PMZ failure due to low heat input and in case of high heat input GTA welding process failure occurs in the PMZ.

Effect of beam oscillation on borated stainless steel electron beam welds

International Nuclear Information System (INIS)

RajaKumar, Guttikonda; Ram, G.D. Janaki; Rao, S.R. Koteswara

2015-01-01

Borated stainless steels are used in nuclear power plants to control neutron criticality in reactors as control rods, shielding material, spent fuel storage racks and transportation casks. In this study, bead on plate welds were made using gas tungsten arc welding (GTAW) and electron beam welding (EBW) processes. Electron beam welds made using beam oscillation technique exhibited higher tensile strength values compared to that of GTA welds. Electron beam welds were found to show fine dendritic microstructure while GTA welds exhibited larger dendrites. While both processes produced defect free welds, GTA welds are marked by partially melted zone (PMZ) where the hardness is low. EBW obviate the PMZ failure due to low heat input and in case of high heat input GTA welding process failure occurs in the PMZ.

Quality of Life Theory II. Quality of Life as the Realization of Life Potential: A Biological Theory of Human Being

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Soren Ventegodt

2003-01-01

Full Text Available This review presents one of the eight theories of the quality of life (QOL used for making the SEQOL (self-evaluation of quality of life questionnaire or the quality of life as realizing life potential. This theory is strongly inspired by Maslow and the review furthermore serves as an example on how to fulfill the demand for an overall theory of life (or philosophy of life, which we believe is necessary for global and generic quality-of-life research.Whereas traditional medical science has often been inspired by mechanical models in its attempts to understand human beings, this theory takes an explicitly biological starting point. The purpose is to take a close view of life as a unique entity, which mechanical models are unable to do. This means that things considered to be beyond the individual's purely biological nature, notably the quality of life, meaning in life, and aspirations in life, are included under this wider, biological treatise. Our interpretation of the nature of all living matter is intended as an alternative to medical mechanism, which dates back to the beginning of the 20th century. New ideas such as the notions of the human being as nestled in an evolutionary and ecological context, the spontaneous tendency of self-organizing systems for realization and concord, and the central role of consciousness in interpreting, planning, and expressing human reality are unavoidable today in attempts to scientifically understand all living matter, including human life.

Life and Death of a Neuron

Science.gov (United States)

... order to clear debris. Hope Through Research Scientists hope that by understanding more about the life and death of neurons they can develop new ... NIH is appreciated. Patient & Caregiver Education ... Your Brain Preventing Stroke Understanding Sleep The Life and Death of a Neuron Genes At Work ...

Assessment of primary school students’ level of understanding the concepts of 2nd grade life sciences course based on different variables

Directory of Open Access Journals (Sweden)

Altıntaş Gülşen

2016-01-01

Full Text Available The course of Life Sciences is one of the pivot courses taught in the first three years of primary school. Ensuring children get to know their environment and gain correct information related to their problems by making them investigate their natural and socio-cultural environment as well as providing them with necessary information, skills and behaviors for environmental adaptation are among the main purposes of Life Sciences course. The concepts to be instilled in students in line with these purposes are important. Since concepts are mostly intellectual and non-physical, they can only exist tangibly through examples. This study aims to assess Primary School Students’ Level of Understanding the Concepts of 2nd Grade Life Sciences Course Based on Different Variables. 17 concepts included in the 2nd Grade Life Sciences course within the subject of School Excitement were addressed within the study, and students were requested to define and exemplify these concepts. A total of 102 students from five different primary schools of upper-middle and lower socioeconomic classes located in Manisa and Istanbul were included in the study in line with the intentional maximum diversity sample selection. The answers given by students for each concept were categorized and analyzed in terms of liking or disliking home, school, technology and the course of Life Sciences.

Orion Ground Test Article Water Impact Tests: Photogrammetric Evaluation of Impact Conditions

Science.gov (United States)

Vassilakos, Gregory J.; Mark, Stephen D.

2018-01-01

The Ground Test Article (GTA) is an early production version of the Orion Crew Module (CM). The structural design of the Orion CM is being developed based on LS-DYNA water landing simulations. As part of the process of confirming the accuracy of LS-DYNA water landing simulations, the GTA water impact test series was conducted at NASA Langley Research Center (LaRC) to gather data for comparison with simulations. The simulation of the GTA water impact tests requires the accurate determination of the impact conditions. To accomplish this, the GTA was outfitted with an array of photogrammetry targets. The photogrammetry system utilizes images from two cameras with a specialized tracking software to determine time histories for the 3-D coordinates of each target. The impact conditions can then be determined from the target location data.

Inner work life: understanding the subtext of business performance.

Science.gov (United States)

Amabile, Teresa M; Kramer, Steven J

2007-05-01

Anyone in management knows that employees have their good days and their bad days--and that, for the most part, the reasons for their ups and downs are unknown. Most managers simply shrug their shoulders at this fact of work life. But does it matter, in terms of performance, if people have more good days than bad days? Teresa Amabile and Steven Kramer's new stream of research, based on more than 12,000 diary entries logged by knowledge workers over three years, reveals the dramatic impact of employees' inner work lives--their perceptions, emotions, and motivation levels--on several dimensions of performance. People perform better when their workday experiences include more positive emotions, stronger intrinsic motivation (passion for the work), and more favorable perceptions of their work, their team, their leaders, and their organization. What the authors also found was that managers' behavior dramatically affects the tenor of employees' inner work lives. So what makes a difference to inner work life? When the authors compared the study participants' best days to their worst days, they found that the single most important differentiator was their sense of being able to make progress in their work. The authors also observed interpersonal events working in tandem with progress events. Praise without real work progress, or at least solid efforts toward progress, had little positive impact on people's inner work lives and could even arouse cynicism. On the other hand, good work progress without any recognition--or, worse, with criticism about trivial issues--could engender anger and sadness. Far and away, the best boosts to inner work life were episodes in which people knew they had done good work and their managers appropriately recognized that work.

LifeWatch - a Large-scale eScience Infrastructure to Assist in Understanding and Managing our Planet's Biodiversity

Science.gov (United States)

Hernández Ernst, Vera; Poigné, Axel; Los, Walter

2010-05-01

Understanding and managing the complexity of the biodiversity system in relation to global changes concerning land use and climate change with their social and economic implications is crucial to mitigate species loss and biodiversity changes in general. The sustainable development and exploitation of existing biodiversity resources require flexible and powerful infrastructures offering, on the one hand, the access to large-scale databases of observations and measures, to advanced analytical and modelling software, and to high performance computing environments and, on the other hand, the interlinkage of European scientific communities among each others and with national policies. The European Strategy Forum on Research Infrastructures (ESFRI) selected the "LifeWatch e-science and technology infrastructure for biodiversity research" as a promising development to construct facilities to contribute to meet those challenges. LifeWatch collaborates with other selected initiatives (e.g. ICOS, ANAEE, NOHA, and LTER-Europa) to achieve the integration of the infrastructures at landscape and regional scales. This should result in a cooperating cluster of such infrastructures supporting an integrated approach for data capture and transmission, data management and harmonisation. Besides, facilities for exploration, forecasting, and presentation using heterogeneous and distributed data and tools should allow the interdisciplinary scientific research at any spatial and temporal scale. LifeWatch is an example of a new generation of interoperable research infrastructures based on standards and a service-oriented architecture that allow for linkage with external resources and associated infrastructures. External data sources will be established data aggregators as the Global Biodiversity Information Facility (GBIF) for species occurrences and other EU Networks of Excellence like the Long-Term Ecological Research Network (LTER), GMES, and GEOSS for terrestrial monitoring, the

Globalization and Life History Research: Fragments of a Life Foretold

Science.gov (United States)

Tierney, William G.

2010-01-01

The goal of this paper is to understand, by way of a life history of one low-income working-class youth, how globalization impacts the working class in a developing nation. The concept of globalization and the method of life history seem diametrically opposed. Globalization is an idea about large social forces that impact the economic and material…

Death in life or life in death? Dementia's ontological challenge.

Science.gov (United States)

Macdonald, Gaynor

2018-01-01

Is it possible to end one's life well with dementia? The perception of dementia as death brought into life flows from ideas about humanness embedded in medicine's Cartesian paradigm. Dementia as incurable brain disease exacerbates negativity. But the real impact of dementia is that it changes social relations: to live well with dementia requires a relational not Cartesian understanding of life. A relational ontology prioritizes social health: to live is to be held in connection. Negativity produces the disconnection that is death, with or without disease. When people with dementia are held in connection, they live a better life.

Micro-macro understanding of fatigue of fibre composites

DEFF Research Database (Denmark)

Sørensen, Bent F.

2014-01-01

Degradation of composite materials during cyclic loading is being better understood. Better understanding enables better material models and the development of more durable composite materials that have longer life for e.g. wind turbine rotor blades......Degradation of composite materials during cyclic loading is being better understood. Better understanding enables better material models and the development of more durable composite materials that have longer life for e.g. wind turbine rotor blades...

Sandia National Laboratories: Careers: Work-Life Balance

Science.gov (United States)

; Culture Work-Life Balance Special Programs Students and Postdocs Benefits and Perks Hiring Process Life at -Life Balance Careers Work-Life Balance People in park Your life is not just work We understand your healthy, multidimensional lifestyle and achieve a personal balance between home, work, and community life

Understanding Interest in the Second Year of Life

Science.gov (United States)

MacPherson, Amy C.; Moore, Chris

2010-01-01

Infants (n = 24, mean age 13 months and n = 24, mean age 19 months) were tested on an extension of the method introduced by Tomasello and Haberl (2003) to examine the understanding of another person's interest in a novel object. Four objects were presented serially. For two objects, infants played with an experimenter. The infant played with one…

Life after weight-loss surgery

Science.gov (United States)

... eliminate many health problems Improve your quality of life Live longer It is important to understand that there will be many other changes in your life. These include the way you eat, what you ...

Global Trade Alert | CRDI - Centre de recherches pour le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Global Trade Alert (GTA) will provide information in real time on national measures taken during the current global economic downturn that are likely to discriminate against foreign commerce. GTA will complement and go beyond World Trade Organization (WTO) and World Bank monitoring initiatives by identifying affected ...

Development of an End-plug Welding Technology for an Instrumented Fuel Irradiation Test

International Nuclear Information System (INIS)

Kim, Soo Sung; Lee, Chul Yong; Shin, Yoon Taek; Choo, Kee Nam

2010-01-01

The irradiation test of end-plug specimens was planned for the evaluation of nuclear fuels performance. To establish the fabrication process, and for satisfying the requirements of the irradiation test, an orbital-GTA weld machine for the specimens of the dual rods was developed, and the preliminary welding experiments for optimizing the process conditions of the specimens of the dual rods were performed. Dual rods with a 9.5mm diameter and a 0.6mm wall thickness of the cladding tubes and end-plugs have been used and the optimum conditions of the pin-hole welding have also been selected. This paper describes the experimental results of the GTA welds of the specimens of the dual rods and the metallography examinations of the GTA welded specimens for various welding conditions for the instrumented fuel irradiation test. These investigations satisfied the requirements of the instrumented irradiation test and the GTA welds for the specimens of the dual rods at the HANARO research reactor

Achieving mutual understanding in Argentine Sign Language (LSA)

NARCIS (Netherlands)

Manrique Cordeje, M.E.

2017-01-01

How does (mis)understanding works in conversation? Problems of understanding occur all the time in our everyday social life. How does miscommunication happen and how do we deal with it? This thesis reports on how sign language users manage to understand each other based on a large Conversational

Quality of Life (QoL) Survey in Hong Kong: Understanding the Importance of Housing Environment and Needs of Residents from Different Housing Sectors.

Science.gov (United States)

Gou, Zhonghua; Xie, Xiaohuan; Lu, Yi; Khoshbakht, Maryam

2018-01-27

This study presents a Quality of Life (QoL) survey to understand the influence of the housing environment and needs of residents from different housing sectors. The research focuses on Hong Kong where living conditions have become the main affect for people's QoL. Through a household survey using a standard instrument "Word Health Organisation (WHO) Quality of Life-BREF", the article found that among the four WHO QoL domains (Physical Health, Psychological Health, Social Relations And Environment), Environment, particularly its constitute aspect housing environment was the most influential factor for overall quality of life for the public rental housing sector where low-income people live. This research also found that different groups of people have differing needs of their housing environments: the low-income group needs better location and privacy while the medium and high-income groups need better architectural quality. Based on differentiating their needs and wants, this research argues for prioritizing the low-income group's needs for effectively improving their QoL.

Understanding Quality of Working Life of Workers with Intellectual Disabilities

Science.gov (United States)

Flores, Noelia; Jenaro, Cristina; Orgaz, M. Begona; Martin, M. Victoria

2011-01-01

Background: This paper examines the perceived quality of working life of workers with intellectual disabilities. Specifically, this paper looks at participants' perceptions in relation to perceived job demands and resources and their impact on experienced job satisfaction. Methods: In this cross-sectional survey, 507 workers with intellectual…

Physics of the Life Sciences

CERN Document Server

Newman, Jay

2008-01-01

Originally developed for the author's course at Union College, this text is designed for life science students who need to understand the connections of fundamental physics to modern biology and medicine. Almost all areas of modern life sciences integrally involve physics in both experimental techniques and in basic understanding of structure and function. Physics of the Life Sciences is not a watered-down, algebra-based engineering physics book with sections on relevant biomedical topics added as an afterthought. This authoritative and engaging text, which is designed to be covered in a two-semester course, was written with a thoroughgoing commitment to the needs and interests of life science students. Although covering most of the standard topics in introductory physics in a more or less traditional sequence, the author gives added weight and space to concepts and applications of greater relevance to the life sciences. Students benefit from occasional sidebars using calculus to derive fundamental relations,...

AcEST: BP920452 [AcEST

Lifescience Database Archive (English)

Full Text Available quence orphan OS=Schizosaccharomyces po... 34 3.7 tr|A6GTA2|A6GTA2_9BURK Leucyl aminopeptidase OS=Limnobac...ter sp. ... 34 4.9 tr|Q55CE3|Q55CE3_DICDI ZZ-type Zn finger-containing protein OS=D

Getting a life: the emergence of the life story in adolescence.

Science.gov (United States)

Habermas, T; Bluck, S

2000-09-01

In the life story, autobiographical remembering and self-understanding are combined to create a coherent account of one's past. A gap is demonstrated between developmental research on the story-organization of autobiographical remembering of events in childhood and of life narratives in adulthood. This gap is bridged by substantiating D.P. McAdams's (1985) claim that the life story develops in adolescence. Two manifestations of the life story, life narratives and autobiographical reasoning, are delineated in terms of 4 types of global coherence (temporal, biographical, causal, and thematic). A review of research shows that the cognitive tools necessary for constructing global coherence in a life story and the social-motivational demands to construct a life story develop during adolescence. The authors delineate the implications of the life story framework for other research areas such as coping, attachment, psychotherapeutic process, and the organization of autobiographical memory.

Glutaraldehyde cross-linking of amniotic membranes affects their nanofibrous structures and limbal epithelial cell culture characteristics.

Science.gov (United States)

Lai, Jui-Yang; Ma, David Hui-Kang

2013-01-01

Given that the cells can sense nanometer dimensions, the chemical cross-linking-mediated alteration in fibrillar structure of collagenous tissue scaffolds is critical to determining their cell culture performances. This article explores, for the first time, the effect of nanofibrous structure of glutaraldehyde (GTA) cross-linked amniotic membrane (AM) on limbal epithelial cell (LEC) cultivation. Results of ninhydrin assays demonstrated that the amount of new cross-links formed between the collagen chains is significantly increased with increasing the cross-linking time from 1 to 24 hours. By transmission electron microscopy, the AM treated with GTA for a longer duration exhibited a greater extent of molecular aggregation, thereby leading to a considerable increase in nanofiber diameter and resistance against collagenase degradation. In vitro biocompatibility studies showed that the samples cross-linked with GTA for 24 hours are not well-tolerated by the human corneal epithelial cell cultures. When the treatment duration is less than 6 hours, the biological tissues cross-linked with GTA for a longer time may cause slight reductions in 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt, and anti-inflammatory activities. Nevertheless, significant collagen molecular aggregation also enhances the stemness gene expression, indicating a high ability of these AM matrices to preserve the progenitors of LECs in vitro. It is concluded that GTA cross-linking of collagenous tissue materials may affect their nanofibrous structures and corneal epithelial stem cell culture characteristics. The AM treated with GTA for 6 hours holds promise for use as a niche for the expansion and transplantation of limbal epithelial progenitor cells.

Acetate supplementation induces growth arrest of NG2/PDGFRα-positive oligodendroglioma-derived tumor-initiating cells.

Directory of Open Access Journals (Sweden)

Patrick M Long

Full Text Available Cancer is associated with globally hypoacetylated chromatin and considerable attention has recently been focused on epigenetic therapies. N-acetyl-L-aspartate (NAA, the primary storage form of acetate in the brain, and aspartoacylase (ASPA, the enzyme responsible for NAA catalysis to generate acetate and ultimately acetyl-Coenzyme A for histone acetylation, are reduced in oligodendroglioma. The short chain triglyceride glyceryl triacetate (GTA, which increases histone acetylation and inhibits histone deacetylase expression, has been safely used for acetate supplementation in Canavan disease, a leukodystrophy due to ASPA mutation. We demonstrate that GTA induces cytostatic G0 growth arrest of oligodendroglioma-derived cells in vitro, without affecting normal cells. Sodium acetate, at doses comparable to that generated by complete GTA catalysis, but not glycerol also promoted growth arrest, whereas long chain triglycerides promoted cell growth. To begin to elucidate its mechanism of action, the effects of GTA on ASPA and acetyl-CoA synthetase protein levels and differentiation of established human oligodendroglioma cells (HOG and Hs683 and primary tumor-derived oligodendroglioma cells that exhibit some features of cancer stem cells (grade II OG33 and grade III OG35 relative to an oligodendrocyte progenitor line (Oli-Neu were examined. The nuclear localization of ASPA and acetyl-CoA synthetase-1 in untreated cells was regulated during the cell cycle. GTA-mediated growth arrest was not associated with apoptosis or differentiation, but increased expression of acetylated proteins. Thus, GTA-mediated acetate supplementation may provide a safe, novel epigenetic therapy to reduce the growth of oligodendroglioma cells without affecting normal neural stem or oligodendrocyte progenitor cell proliferation or differentiation.

Life as quale

Directory of Open Access Journals (Sweden)

Roland Cazalis

2013-07-01

Full Text Available The developments of relational biology during these last thirty years tend to classify autonomous system such as biological, cognitive or social groups among the living systems which they models as such. This present article tries to understand the nature of life by the transition phase which characterizes the passage from the inanimate world to the organic one. Our proposal is that life belongsto the category of qualia. Consequently, qualia are already obvious at least with the simplest forms of the living world. Furthermore, if life, consciousness and language are emergences of complex entities,life as quale is specifically the self of the cellular organism.

Explaining the Origin of Life is not Enough for a Definition of Life

NARCIS (Netherlands)

Jagers Op Akkerhuis, G.A.J.M.

2011-01-01

The comments focus on a presumed circular reasoning in the operator hierarchy and the necessity of understanding life’s origin for defining life. Below it is shown that its layered structure prevents the operator hierarchy from circular definitions. It is argued that the origin of life is an

Engagement: Looking beyond the mirror to understand action understanding.

Science.gov (United States)

Reddy, Vasudevi; Uithol, Sebo

2016-03-01

In this paper, we argue that the current focus on mirroring as the route to explaining the development of action understanding is misleading and problematic. It facilitates a fundamentally spectatorial stance, ignoring engagement and dialogue; it focuses on similarity between self and other and neglects difference; and it succumbs to the static terminology of mechanism rather than a dynamic language of process. Contrary to this view, dialogic exchanges are evident from the start of life, revealing infants' ability to engage with and respond appropriately to actions that are outside their own motor repertoire. We suggest that engagement rather than mirroring better accounts for many current findings in action understanding. The neurological evidence to date shows that action perception involves a process of continuous synchronization and change, suggesting that it might be more fruitful for research and theory to look beyond mirroring and instead adopt dynamic processual explanations of action understanding within interaction. © 2015 The British Psychological Society.

'Peacekeepers' and 'Machine Factories': Tracing Graduate Teaching Assistant Subjectivity in a Neoliberalised University

Science.gov (United States)

Raaper, Rille

2018-01-01

Guided by a Foucauldian theorisation, this article explores Graduate Teaching Assistant (GTA) experiences of their work and subjectivity in a neoliberalised higher education environment. By drawing on a research project with GTAs from one UK university, the article argues that GTA work is increasingly shaped by neoliberal reforms. The GTAs…

Doulble hermeneutics of the life world

DEFF Research Database (Denmark)

Nørreklit, Lennart

The idea of doduble hermeneutics is presented and its consequences for human and social life analyzed. According to double hermeneutics the understanding of the other is not to obtain knowledge about the pre-understanding of the other, but to understand why the other has the pre-understanding, he...

Staying in "the stream of life"

DEFF Research Database (Denmark)

Rasmussen, Birgitte; Delmar, Charlotte; Dolmer, Ilone

2009-01-01

Staying in the stream of life is about being the author of one's own meaningful life. It takes into account life phenomena embodied in the maintenance aspect of health care; dignity in relation to identity and integrity; and an understanding of the dialectical relation between frailty and strength....

Aging Prisoners’ Treatment Selection: Does Prospect Theory Enhance Understanding of End-of-Life Medical Decisions?

Science.gov (United States)

Phillips, Laura L.; Allen, Rebecca S.; Harris, Grant M.; Presnell, Andrew H.; DeCoster, Jamie; Cavanaugh, Ronald

2011-01-01

Purpose: With the rapid growth in the older inmate population and the economic impact of end-of-life treatments within the cash-strapped prison system, consideration should be given to inmate treatment preferences. We examined end-of-life treatment preferences and days of desired life for several health scenarios among male inmates incarcerated primarily for murder. Design and Methods: Inmates over the age of 45 who passed a cognitive screening completed face-to-face interviews (N = 94; mean age = 57.7; SD = 10.68). Results: We found a 3-way interaction indicating that the effect of parole expectation on desire for life-sustaining treatment varied by race/ethnicity and treatment. Minority inmates desired cardiopulmonary resuscitation or feeding tubes only if they believed that they would be paroled. The model predicting desire for palliative care was not significant. Future days of desired life were related to prospective health condition, fear of death, negative affect, and trust in prison health care. Caucasian inmates expressed a desire for more days of life out of prison, whereas minority inmates did not differ in days of desired life either in or out of prison. Minorities wanted more days of life than Caucasians but only if they believed that they would be paroled. Implications: End-of-life care for the burgeoning inmate population is costly, and active life-sustaining treatments may not be desired under certain conditions. Specifically, expectation of parole but not current functional ability interacts with future illness condition in explaining inmates’ desire for active treatment or days of desired life in the future. PMID:21593007

Six Understandings of the Word Spirituality in a Secular Country

DEFF Research Database (Denmark)

la Cour, Peter; Ausker, Nadja Hørdam; Hvidt, Niels Christian

2012-01-01

Spirituality is a growing research theme, especially in relation to health issues. The term is often poorly defined and one's understanding is often so broad that it becomes a mere frame word devoid of meaning. In this study, we asked 514 adult Danes about their understanding of the word...... `spirituality'. Factor analysis of the answers resulted in six different understandings of spirituality: (1) positive dimensions in human life and well-being; (2) New Age ideology; (3) an integrated part of established religious life; (4) a vague striving, opposed to religion; (5) selfishness; and (6) ordinary...

Quality of life and understanding of disease status among cancer patients of different ethnic origin.

Science.gov (United States)

Tchen, N; Bedard, P; Yi, Q-L; Klein, M; Cella, D; Eremenco, S; Tannock, I F

2003-08-18

Patients managed in European or North American cancer centres have a variety of ethnic backgrounds and primary languages. To gain insight into the impact of ethnic origin, we have investigated understanding of disease status and quality of life (QoL) for 202 patients. Patients completed questionnaires in their first language (52 English, 50 Chinese, 50 Italian, 50 Spanish or Portuguese), including the Functional Assessment of Cancer Therapy - General (FACT-G) QoL instrument, questions about disease status, expectations of cure and the language and/or type of interpretation used at initial consultation. Physicians also evaluated their status of disease and expectation of cure, and performance status was estimated by a trained health professional. The initial consultation was usually provided in English (except for 32% of Chinese-speaking patients); interpretation was provided by a family member for 34% of patients with limited English proficiency (LEP) and by a bilingual member of staff for 21%. Patients underestimated their extent of disease and overestimated their probability of cure (P=0.001 and cultural differences is important for optimal management of patients with cancer.

Understanding the meaning of fatigue at the end of life: an ethnoscience approach.

Science.gov (United States)

Kirshbaum, Marilynne N; Olson, Kärin; Pongthavornkamol, Kanaungnit; Graffigna, Guendalina

2013-04-01

Fatigue is a devastating state of body and mind associated with distress at the end of life. We report the results of the third in a series of papers outlining a novel approach we have developed for understanding the meaning of fatigue by exploring how this meaning is shaped by beliefs and values. The aims of the study were to examine the perception and experiences of fatigue held by patients attending a hospice in England; identify the behavioural patterns that distinguish fatigue from tiredness and exhaustion; provide conceptual definitions of tiredness, fatigue and exhaustion. An Ethnoscience design was selected. The sample comprised nine people who attended a hospice between May and December 2009. Inclusion criteria included: at least 18 years of age, experiencing fatigue, able to provide informed consent and resident in the selected city in northern England for 10 years. Data were collected from two consecutive semi-structured interviews for each participant. We found that tiredness, fatigue and exhaustion are markers of progressive functional decline. Fatigue had two dimensions: 1) Mental Challenge, which included: emotional effects, cognitive realisation of decline and mental tenacity and 2) Physical Challenge, which included: limitations in leisure activities, limitations in functional roles and re-patterning routines. This study provides evidence that symptom experience is socially constructed, which has potential implications for the development of effective interventions. Copyright © 2012 Elsevier Ltd. All rights reserved.

Phun Week: Understanding Physiology

Science.gov (United States)

Limson, Mel; Matyas, Marsha Lakes

2009-01-01

Topics such as sports, exercise, health, and nutrition can make the science of physiology relevant and engaging for students. In addition, many lessons on these topics, such as those on the cardiovascular, respiratory, and digestive systems, align with national and state life science education standards. Physiology Understanding Week (PhUn…

Leadership and Work-Life Balance.

Science.gov (United States)

Mattock, Sarah L

2015-01-01

Simply stated, work-life balance is something that is both difficult to define and difficult to achieve. Leaders, throughout the continuum of trauma care, need to have a sound understanding of what work-life balance means and set an example of a healthy work-life balance for those they lead. This article offers strategies for enhancing work-life balance and challenges individuals to use self-reflection as a means to furthering their personal and professional growth.

Autonomy: Life and Being

Science.gov (United States)

Williams, Mary-Anne

This paper uses robot experience to explore key concepts of autonomy, life and being. Unfortunately, there are no widely accepted definitions of autonomy, life or being. Using a new cognitive agent architecture we argue that autonomy is a key ingredient for both life and being, and set about exploring autonomy as a concept and a capability. Some schools of thought regard autonomy as the key characteristic that distinguishes a system from an agent; agents are systems with autonomy, but rarely is a definition of autonomy provided. Living entities are autonomous systems, and autonomy is vital to life. Intelligence presupposes autonomy too; what would it mean for a system to be intelligent but not exhibit any form of genuine autonomy. Our philosophical, scientific and legal understanding of autonomy and its implications is immature and as a result progress towards designing, building, managing, exploiting and regulating autonomous systems is retarded. In response we put forward a framework for exploring autonomy as a concept and capability based on a new cognitive architecture. Using this architecture tools and benchmarks can be developed to analyze and study autonomy in its own right as a means to further our understanding of autonomous systems, life and being. This endeavor would lead to important practical benefits for autonomous systems design and help determine the legal status of autonomous systems. It is only with a new enabling understanding of autonomy that the dream of Artificial Intelligence and Artificial Life can be realized. We argue that designing systems with genuine autonomy capabilities can be achieved by focusing on agent experiences of being rather than attempting to encode human experiences as symbolic knowledge and know-how in the artificial agents we build.

Understanding Values in a Large Health Care Organization through Work-Life Narratives of High-Performing Employees

Science.gov (United States)

Karnieli-Miller, Orit; Taylor, Amanda C.; Inui, Thomas S.; Ivy, Steven S.; Frankel, Richard M.

2011-01-01

Objective— To understand high-performing frontline employees’ values as reflected in their narratives of day-to-day interactions in a large health care organization. Methods— A total of 150 employees representing various roles within the organization were interviewed and asked to share work-life narratives (WLNs) about value-affirming situations (i.e. situations in which they believed their actions to be fully aligned with their values) and value-challenging situations (i.e. when their actions or the actions of others were not consistent with their values), using methods based on appreciative inquiry. Results— The analysis revealed 10 broad values. Most of the value-affirming WLNs were about the story-teller and team providing care for the patient/family. Half of the value-challenging WLNs were about the story-teller or a patient and barriers created by the organization, supervisor, or physician. Almost half of these focused on “treating others with disrespect/respect”. Only 15% of the value-challenging WLNs contained a resolution reached by the participants, often leaving them describing unresolved and frequently negative feelings. Conclusions— Appreciative inquiry and thematic analysis methods were found to be an effective tool for understanding the important and sometimes competing role personal and institutional values play in day-to-day work. There is remarkable potential in using WLNs as a way to surface and reinforce shared values and, perhaps more importantly, respectfully to identify and discuss conflicting personal and professional values. PMID:23908820

Understanding the role that Quality of Work Life of food and ...

African Journals Online (AJOL)

Work Life plays in the perceived service delivery and productivity of food and beverage ... that job, creativity and aesthetics, actualisation, organisational support and employee commitment attributes each exert an influence on the perceived ...

Understanding the biological underpinnings of ecohydrological processes

Science.gov (United States)

Huxman, T. E.; Scott, R. L.; Barron-Gafford, G. A.; Hamerlynck, E. P.; Jenerette, D.; Tissue, D. T.; Breshears, D. D.; Saleska, S. R.

2012-12-01

Climate change presents a challenge for predicting ecosystem response, as multiple factors drive both the physical and life processes happening on the land surface and their interactions result in a complex, evolving coupled system. For example, changes in surface temperature and precipitation influence near-surface hydrology through impacts on system energy balance, affecting a range of physical processes. These changes in the salient features of the environment affect biological processes and elicit responses along the hierarchy of life (biochemistry to community composition). Many of these structural or process changes can alter patterns of soil water-use and influence land surface characteristics that affect local climate. Of the many features that affect our ability to predict the future dynamics of ecosystems, it is this hierarchical response of life that creates substantial complexity. Advances in the ability to predict or understand aspects of demography help describe thresholds in coupled ecohydrological system. Disentangling the physical and biological features that underlie land surface dynamics following disturbance are allowing a better understanding of the partitioning of water in the time-course of recovery. Better predicting the timing of phenology and key seasonal events allow for a more accurate description of the full functional response of the land surface to climate. In addition, explicitly considering the hierarchical structural features of life are helping to describe complex time-dependent behavior in ecosystems. However, despite this progress, we have yet to build an ability to fully account for the generalization of the main features of living systems into models that can describe ecohydrological processes, especially acclimation, assembly and adaptation. This is unfortunate, given that many key ecosystem services are functions of these coupled co-evolutionary processes. To date, both the lack of controlled measurements and experimentation

Relationships Between Dimensions of Anxiety and Sensation Seeking

Science.gov (United States)

Burkhart, Barry R.; And Others

1978-01-01

Undergraduates (130 males, 112 females) completed the Sensation Seeking Scale (SSS) and the S-R Inventory of General Trait Anxiousness (S-R GTA). The intercorrelations among the five scales from the SSS and the four scales from the S-R GTA were computed and compared. Findings were consistent with rational and theoretical notions. (Author)

Modeling Sources of Teaching Self-Efficacy for Science, Technology, Engineering, and Mathematics Graduate Teaching Assistants

Science.gov (United States)

DeChenne, Sue Ellen; Koziol, Natalie; Needham, Mark; Enochs, Larry

2015-01-01

Graduate teaching assistants (GTAs) in science, technology, engineering, and mathematics (STEM) have a large impact on undergraduate instruction but are often poorly prepared to teach. Teaching self-efficacy, an instructor’s belief in his or her ability to teach specific student populations a specific subject, is an important predictor of teaching skill and student achievement. A model of sources of teaching self-efficacy is developed from the GTA literature. This model indicates that teaching experience, departmental teaching climate (including peer and supervisor relationships), and GTA professional development (PD) can act as sources of teaching self-efficacy. The model is pilot tested with 128 GTAs from nine different STEM departments at a midsized research university. Structural equation modeling reveals that K–12 teaching experience, hours and perceived quality of GTA PD, and perception of the departmental facilitating environment are significant factors that explain 32% of the variance in the teaching self-efficacy of STEM GTAs. This model highlights the important contributions of the departmental environment and GTA PD in the development of teaching self-efficacy for STEM GTAs. PMID:26250562

Implementing Life Cycle Assessment in Product development

DEFF Research Database (Denmark)

Bhander, Gurbakhash Singh

2003-01-01

The overall aim of the paper is to provide an understanding of the environmental issues involved in the early stages of product development and the capacity of life cycle assessment techniques to address these issues. The paper aims to outline the problems for the designer in evaluating the envir......The overall aim of the paper is to provide an understanding of the environmental issues involved in the early stages of product development and the capacity of life cycle assessment techniques to address these issues. The paper aims to outline the problems for the designer in evaluating......, and of the opportunities for introducing environmental criteria in the design process through meeting the information requirements of the designer on the different life cycle stages, producing an in-depth understanding of the attitudes of practitioners among product developers to the subject area, and an understanding...... of possible future directions for product development. An Environmentally Conscious Design method is introduced and trade-offs are presented between design degrees of freedom and environmental solutions. Life cycle design frameworks and strategies are addressed. The paper collects experiences and ideas around...

Commissioning of the Ground Test Accelerator Intertank Matching Section

International Nuclear Information System (INIS)

Johnson, K.F.; Sander, O.R.; Atkins, W.H.; Bolme, G.O.; Cole, R.; Connolly, R.; Gilpatrick, J.D.; Ingalls, W.B.; Kersteins, D.; Little, C.; Lohsen, R.A.; Lysenko, W.P.; Mottershead, C.T.; Power, J.; Rusthoi, D.P.; Sandoval, D.P.; Stevens, R.R.; Vaughn, G.; Wadlinger, E.A.; Weiss, R.; Yuan, V.

1992-01-01

The Ground Test Accelerator (GTA) has the objective of verifying much of the technology (physics and engineering) required for producing high-brightness, high-current H - beams. GTA commissioning is staged to verify the beam dynamics design of each major accelerator component as it is brought on-line. The commissioning stages are the 35 keV H - injector, the 2.5 MeV Radio Frequency Quadrupole (RFQ), the Intertank Matching Section (IMS), the 3.2 MeV first 2βγ Drift Tube Linac (DTL-1) module, the 8.7 MeV 2βγ DTL (modules 1--5), and the 24 MeV GTA; all 10 DTL modules. Commissioning results from the IMS beam experiments will be presented

The government of life

DEFF Research Database (Denmark)

Villadsen, Kaspar; Wahlberg, Ayo

2015-01-01

. Subsequent research on biopolitics and governmentality has tended to separate the concepts, differentiating into distinct research traditions each with different intellectual pathways. We propose to bring these conceptual innovations together to understand contemporary problems of the government of life...... of death power, the interplay of sovereignty, discipline and security, governmentalization through medical normalization, and ‘securitization’ of life as circulations and open series. The article also introduces this special feature on the government of life in which significant scholars explores issues...

Why do we need a semiotic understanding of life?

DEFF Research Database (Denmark)

Hoffmeyer, Jesper

2013-01-01

experience of agency as an inherent property of life. Biologist of today embraces natural selection theory because it opens the doors for biology to become an exact science. In the same time, however, biology seems unable to get rid of teleological language which implicitly contradicts the non-agency premise......, in other words, the capacity to interpret signs. These signs need not be emitted with a purpose of communication, in fact by far the most signs are not part of a sender-receiver interaction but are simply important cues (internal or external) that organisms use to guide their activities. The chapter...

Self-caring in later life

DEFF Research Database (Denmark)

Fristrup, Tine; Grut, Sara

2015-01-01

. The phenomenon of gerontopedagogicalisation is a process of becoming a juvenile and entrepreneurial self in later life, conceptualised as performAGE (Fristrup, 2012a). PerformAGE is an approach to understanding the different ways of performing age in later life which favours the performing of this juvenile...

Disrupted Refugee Family Life

DEFF Research Database (Denmark)

Shapiro, Ditte Krogh

2017-01-01

Fleeing civil war involves managing life threatening events and multiple disruptions of everyday life. The theoretical potentials of analysing the recreation of everyday family life among Syrian refugees in Denmark is explored based on conceptualizations that emphasize the collective agency...... of family members in social historical contexts. Studying the multiple perspectives of family members shows how social support conceptualized as care practises is conflictual in the changing everyday family practices that are transformed by policy. The purpose of studying how families manage to flee civil...... war and struggle to recreate an everyday life in exile is to contribute with contextualization and expansion of mainstream understandings of family life, suffering, and resilience in refugee family trajectories in multiple contexts....

Understanding Life Cycle Assessment: Applications for OSWER's Land and Materials Managment

Science.gov (United States)

The Office of Superfund Remediation and Technology Innovation (OSRTI) is hosting an informative webcast presentation by Jane Bare, expert on Life Cycle Impact Assessment (LCIA) in EPA's Office of Research and Development. Ms. Bare's presentation will provide an overview of LCIA, ...

Life History Approach

DEFF Research Database (Denmark)

Olesen, Henning Salling

2015-01-01

as in everyday life. Life histories represent lived lives past, present and anticipated future. As such they are interpretations of individuals’ experiences of the way in which societal dynamics take place in the individual body and mind, either by the individual him/herself or by another biographer. The Life...... History approach was developing from interpreting autobiographical and later certain other forms of language interactive material as moments of life history, i.e. it is basically a hermeneutic approach. Talking about a psycho-societal approach indicates the ambition of attacking the dichotomy...... of the social and the psychic, both in the interpretation procedure and in some main theoretical understandings of language, body and mind. My article will present the reflections on the use of life history based methodology in learning and education research as a kind of learning story of research work....

The Life of Digital Photographs

DEFF Research Database (Denmark)

Larsen, Jonas

)mobilities of things, practice approaches to photography and multi sited ethnography, this talk discusses and empirically track the life (the conception, birth, transformative years, ageing and death) travel, detours, makeovers and destinations of (analogue and digital) photographs in our present network societies. So...... we can understand the life of more-than representational photographs, and then I turn to my ethnographies to flesh out empirically the life of tourist photographs...

Understanding uncertainty

CERN Document Server

Lindley, Dennis V

2013-01-01

Praise for the First Edition ""...a reference for everyone who is interested in knowing and handling uncertainty.""-Journal of Applied Statistics The critically acclaimed First Edition of Understanding Uncertainty provided a study of uncertainty addressed to scholars in all fields, showing that uncertainty could be measured by probability, and that probability obeyed three basic rules that enabled uncertainty to be handled sensibly in everyday life. These ideas were extended to embrace the scientific method and to show how decisions, containing an uncertain element, could be rationally made.

BREATHE to Understand©

Science.gov (United States)

Swisa, Maxine

2015-01-01

BREATHE is an acronym for Breathe, Reflect, Empathize, Accept, Thank, Hearten, Engage. The addition of Understand allows for a holistic approach to living a healthy and balanced life both inside and outside the classroom. This paper took form as a result of my personal, spiritual journey, as well as my teaching practice. I noticed that the…

Oxidative stress and life histories: unresolved issues and current needs

OpenAIRE

Speakman, John R.; Blount, Jonathan D.; Bronikowski, Anne M.; Buffenstein, Rochelle; Isaksson, Caroline; Kirkwood, Tom B. L.; Monaghan, Pat; Ozanne, Susan E.; Beaulieu, Micha?l; Briga, Michael; Carr, Sarah K.; Christensen, Louise L.; Cochem?, Helena M.; Cram, Dominic L.; Dantzer, Ben

2015-01-01

Abstract Life?history theory concerns the trade?offs that mold the patterns of investment by animals between reproduction, growth, and survival. It is widely recognized that physiology plays a role in the mediation of life?history trade?offs, but the details remain obscure. As life?history theory concerns aspects of investment in the soma that influence survival, understanding the physiological basis of life histories is related, but not identical, to understanding the process of aging. One i...

Aging Prisoners' Treatment Selection: Does Prospect Theory Enhance Understanding of End-of-Life Medical Decisions?

Science.gov (United States)

Phillips, Laura L.; Allen, Rebecca S.; Harris, Grant M.; Presnell, Andrew H.; DeCoster, Jamie; Cavanaugh, Ronald

2011-01-01

Purpose: With the rapid growth in the older inmate population and the economic impact of end-of-life treatments within the cash-strapped prison system, consideration should be given to inmate treatment preferences. We examined end-of-life treatment preferences and days of desired life for several health scenarios among male inmates incarcerated…

Life History Patterns

DEFF Research Database (Denmark)

Jones, Owen

2016-01-01

of these patterns and highlights the need to consider senescence from a broad taxonomic scope to truly understand the evolution of aging. Keywords: Aging; Demography; Evolution; Fertility; Gompertz; Life span; Mortality; Ontogenescence; Reproduction; Reproductive senescence; Senescence; Survivorship...

Life Writing After Empire

DEFF Research Database (Denmark)

A watershed moment of the twentieth century, the end of empire saw upheavals to global power structures and national identities. However, decolonisation profoundly affected individual subjectivities too. Life Writing After Empire examines how people around the globe have made sense of the post...... in order to understand how individual life writing reflects broader societal changes. From far-flung corners of the former British Empire, people have turned to life writing to manage painful or nostalgic memories, as well as to think about the past and future of the nation anew through the personal...

The Interplay between Women's Life Course Work Patterns and Financial Planning for Later Life

Science.gov (United States)

Berger, Ellie D.; Denton, Margaret A.

2004-01-01

In order to gain a comprehensive understanding of the interplay between women's life course work patterns and their financial planning for later life, we examined data from semi-structured interviews with retired women (n = 28) aged 59 to 92. The majority of women disrupted their careers at some point in time, for an average of 14 years, primarily…

CCM - Understanding and working with Competencies

CERN Multimedia

HR Department

2011-01-01

Find out what competencies are, make them come to life by sharing your experience with colleagues, and understand what they represent in our work environment. All staff members are encouraged to attend. Register here for sessions in June.

Accelerator Technology Division progress report, FY 1993

International Nuclear Information System (INIS)

Schriber, S.O.; Hardekopf, R.A.; Heighway, E.A.

1993-01-01

This report discusses the following topics: A Next-Generation Spallation-Neutron Source; Accelerator Performance Demonstration Facility; APEX Free-Electron Laser Project; The Ground Test Accelerator (GTA) Program; Intense Neutron Source for Materials Testing; Linac Physics and Special Projects; Magnetic Optics and Beam Diagnostics; Radio-Frequency Technology; Accelerator Controls and Automation; Very High-Power Microwave Sources and Effects; and GTA Installation, Commissioning, and Operation

Is life supernatural?

Science.gov (United States)

Levin, Gilbert V.

2015-09-01

The big question of the origin of life is examined. The paradox created by Pasteur's resounding edict: Life only comes from life, pitted against the need for spontaneous generation is explored. This seemingly dead-end conundrum contrasts sharply with the great progress we have made in understanding the evolution of the species since Darwin's revolutionary insight. The conditions and sources of energy that might have promoted non-living molecules and compounds to cross the sharp line from inert to living are contemplated. Abiotic synthesis might help explain the origin, but still fails to explain the moment of vitalization. A different approach to discovering when the inert becomes alive is proposed. The need for, and a way to bring forth, a "Bio-Einstein" to solve this penultimate question of life's origin are presented.

Inquiry-based training improves teaching effectiveness of biology teaching assistants

Science.gov (United States)

Hughes, P. William; Ellefson, Michelle R.

2013-01-01

Graduate teaching assistants (GTAs) are used extensively as undergraduate science lab instructors at universities, yet they often have having minimal instructional training and little is known about effective training methods. This blind randomized control trial study assessed the impact of two training regimens on GTA teaching effectiveness. GTAs teaching undergraduate biology labs (n = 52) completed five hours of training in either inquiry-based learning pedagogy or general instructional “best practices”. GTA teaching effectiveness was evaluated using: (1) a nine-factor student evaluation of educational quality; (2) a six-factor questionnaire for student learning; and (3) course grades. Ratings from both GTAs and undergraduates indicated that indicated that the inquiry-based learning pedagogy training has a positive effect on GTA teaching effectiveness. PMID:24147138

Commissioning of the Ground Test Accelerator RFQ

International Nuclear Information System (INIS)

Johnson, K.F.; Sander, O.R.; Atkins, W.H.; Bolme, G.O.; Brown, S.; Connolly, R.; Garnett, R.; Gilpatrick, J.D.; Guy, F.W.; Ingalls, W.B.; Little, C.; Lohson, R.A.; Lloyd, S.; Neuschaefer, G.; Power, J.; Saadatmand, K.; Sandoval, D.P.; Stevens, R.R.; Vaughn, G.; Wadlinger, E.A.; Weiss, R.; Yuan, V.

1992-01-01

The Ground Test Accelerator (GTA) has the objective of verifying much of the technology (physics and engineering) required for producing high-brightness, high-current H - beams. GTA commissioning is staged to verify the beam dynamics design of each major accelerator component as it is brought on-line. The commissioning stages are the 35 key H - injector, the 2.5 MeV Radio Frequency Quadrupole (RFQ), the Intertank Matching Section (IMS), the 3.2 MeV first 2βγ Drift Tube Linac (DTL-1) module, the 8.7 MeV 2βγ DTL (modules 1--5), and the 24 MeV GTA; all 10 DTL modules. Commissioning results from the RFQ beam experiments will be presented along with comparisons to simulations

Commissioning of the ground test accelerator RFQ

International Nuclear Information System (INIS)

Johnson, K.F.; Sander, O.R.; Atkins, W.H.; Bolme, G.O.; Brown, S.; Garnott, R.; Gilpatrick, J.D.; Guy, F.W.; Ingalls, W.B.; Little, C.; Lohsen, R.A.; Lloyd, S.; Neuschaefer, G.; Power, J.; Sandoval, D.P.; Saadatmand, K.; Stevens, R.R.Jr.; Vaughn, G.; Wadlinger, E.A.; Yuan, V.; Connolly, R.; Weiss, R.

1992-01-01

The Ground Test Accelerator (GTA) has the objective of verifying much of the technology (physics and engineering) required for producing high-brightness, high-current H - beams. GTA commissioning is staged to verify the beam dynamics design of each major accelerator component as it is brought on line. The commissioning stages are the 35-keV H - injector, the 2.5-MeV radio-frequency quadrupole (RFQ), the intertank matching section (IMS), the 3.2-MeV first 2-βλ drift tube linac (DTL-1) module, the 8.7-MeV 2-βλDTL (modules 1-5), and the 24-MeV GTA (all 10 DTL modules). Commissioning results from the RFQ beam experiments are presented along with comparisons with simulations. (Author) 8 refs., 9 figs

Life cycle and nano-products: end-of-life assessment

International Nuclear Information System (INIS)

Asmatulu, Eylem; Twomey, Janet; Overcash, Michael

2012-01-01

Understanding environmental impacts of nanomaterials necessitates analyzing the life cycle profile. The initial emphasis of nanomaterial life cycle studies has been on the environmental and health effects of nanoproducts during the production and usage stages. Analyzing the end-of-life (eol) stage of nanomaterials is also critical because significant impacts or benefits for the environment may arise at that particular stage. In this article, the Woodrow Wilson Center’s Project on Emerging Nanotechnologies (PEN) Consumer Products Inventory (CPI) model was used, which contains a relatively large and complete nanoproduct list (1,014) as of 2010. The consumer products have wide range of applications, such as clothing, sports goods, personal care products, medicine, as well as contributing to faster cars and planes, more powerful computers and satellites, better micro and nanochips, and long-lasting batteries. In order to understand the eol cycle concept, we allocated 1,014 nanoproducts into the nine end-of-life categories (e.g., recyclability, ingestion, absorption by skin/public sewer, public sewer, burning/landfill, landfill, air release, air release/public sewer, and other) based on probable final destinations of the nanoproducts. This article highlights the results of this preliminary assessment of end-of-life stage of nanoproducts. The largest potential eol fate was found to be recyclability, however little literature appears to have evolved around nanoproduct recycling. At lower frequency is dermal and ingestion human uptake and then landfill. Release to water and air are much lower potential eol fates for current nanoproducts. In addition, an analysis of nano-product categories with the largest number of products listed indicated that clothes, followed by dermal-related products and then sports equipment were the most represented in the PEN CPI (http

Life cycle and nano-products: end-of-life assessment

Energy Technology Data Exchange (ETDEWEB)

Asmatulu, Eylem; Twomey, Janet; Overcash, Michael, E-mail: mrovercash@earthlink.net [Wichita State University, Department of Industrial and Manufacturing Engineering (United States)

2012-03-15

Understanding environmental impacts of nanomaterials necessitates analyzing the life cycle profile. The initial emphasis of nanomaterial life cycle studies has been on the environmental and health effects of nanoproducts during the production and usage stages. Analyzing the end-of-life (eol) stage of nanomaterials is also critical because significant impacts or benefits for the environment may arise at that particular stage. In this article, the Woodrow Wilson Center's Project on Emerging Nanotechnologies (PEN) Consumer Products Inventory (CPI) model was used, which contains a relatively large and complete nanoproduct list (1,014) as of 2010. The consumer products have wide range of applications, such as clothing, sports goods, personal care products, medicine, as well as contributing to faster cars and planes, more powerful computers and satellites, better micro and nanochips, and long-lasting batteries. In order to understand the eol cycle concept, we allocated 1,014 nanoproducts into the nine end-of-life categories (e.g., recyclability, ingestion, absorption by skin/public sewer, public sewer, burning/landfill, landfill, air release, air release/public sewer, and other) based on probable final destinations of the nanoproducts. This article highlights the results of this preliminary assessment of end-of-life stage of nanoproducts. The largest potential eol fate was found to be recyclability, however little literature appears to have evolved around nanoproduct recycling. At lower frequency is dermal and ingestion human uptake and then landfill. Release to water and air are much lower potential eol fates for current nanoproducts. In addition, an analysis of nano-product categories with the largest number of products listed indicated that clothes, followed by dermal-related products and then sports equipment were the most represented in the PEN CPI (http

Middle school students' understanding of the natural history of the Earth and life on Earth as a function of deep time

Science.gov (United States)

Pulling, Azalie Cecile

The purpose of this study was to use deep time, that is geologic time as a mechanism to explore middle school students' understanding of the natural history of the earth and the evolution of life on earth. Geologic time is a logical precursor to middle school students' understanding of biological evolution. This exploratory, mixed model study used qualitative and quantitative methods in each stage of the research to explore sixth grade students, understanding of geologic time, their worldviews (e.g., conceptual ecology), and conceptual change. The study included fifty-nine students in the large group study and four case studies. The primary data collection instrument was the Geologic Timeline Survey. Additional data collection instruments and methods (e.g., concept evaluation statement, journal entries, word associations, interviews, and formal tests) were used to triangulate the study findings. These data were used to create narrative modal profiles of the categories of student thinking that emerged from the large group analysis: Middle School (MS) Scientists (correct science), MS Protoscientists (approaching correct science), MS Prescientists (dinosaur understanding), and MS Pseudoscientists (fundamental religious understanding). Case studies were used to provide a thick description of each category. This study discovered a pattern of student thinking about geologic time that moved along a knowledge continuum from pseudoscience (fundamental creationist understanding) to prescience (everyday-science understanding) to science (correct or approaching correct science). The researcher described the deep-seated misconceptions produced by the prescience thinking level, e.g., dinosaur misconceptions, and cautioned the science education community about using dinosaurs as a glamour-science topic. The most limiting conceptual frameworks found in this study were prescience (a dinosaur focus) and pseudoscience (a fundamental religious focus). An understanding of geologic time

Understanding Technology?

Directory of Open Access Journals (Sweden)

Erik Bendtsen

2016-11-01

Full Text Available We are facing radical changes in our ways of living in the nearest future. Not necessarily of our own choice, but because tchnological development is moving so fast, that it will have still greater impact on many aspects of our lives. We have seen the beginnings of that change within the latest 35 years or so, but according to newest research that change will speed up immensely in the nearest years to come. The impact of that change or these changes will affect our working life immensely as a consequence of automation. How these changes are brought about and which are their consequences in a broad sense is being attempted to be understood and guessed by researchers. No one knows for sure, but specific patterns are visible. This paper will not try to guess, what will come, but will rather try to understand the deepest ”nature” of technology in order to understand the driving factors in this development: the genesis of technology in a broad sense in order to contibute to the understanding of the basis for the expected development.

Life between buildings

DEFF Research Database (Denmark)

Gehl, Jan

2001-01-01

A classic is republished. Life between Buildings was first published in 1971. This book - frequently revised over the years - is still the best source for understanding how people use public spaces in our cities. Published in many languages, it is a standard textbook in Architecture and Planning...... Schools around the world, and continues to be the undisputed basic introduction to the interplay between public space design and social life. This book is now available in its third English language version....

Generations and Gender Survey (GGS: Towards a Better Understanding of Relationships and Processes in the Life Course

Directory of Open Access Journals (Sweden)

Zsolt Spéder

2007-11-01

Full Text Available The Generations and Gender Survey (GGS is one of the two pillars of the Generations and Gender Programme designed to improve understanding of demographic and social development and of the factors that influence these developments. This article describes how the theoretical perspectives applied in the survey, the survey design and the questionnaire are related to this objective. The key features of the survey include panel design, multidisciplinarity, comparability, context-sensitivity, inter-generational and gender relationships. The survey applies the life course approach, focussing on the processes of childbearing, partnership dynamics, home leaving, and retiring. The selection of topics for data collection mainly follows the criterion of theoretically grounded relevance to explaining one or more of the mentioned processes. A large portion of the survey deals with economic aspects of life, such as economic activity, income, and economic well-being; a comparably large section is devoted to values and attitudes. Other domains covered by the survey include gender relationships, household composition and housing, residential mobility, social networks and private transfers, education, health, and public transfers. The third chapter of the article describes the motivations for their inclusion. The GGS questionnaire is designed for a face-to-face interview. It includes the core that each participating country needs to implement in full, and four optional sub-modules on nationality and ethnicity, on previous partners, on intentions of breaking up, and on housing, respectively. The participating countries are encouraged to include also the optional sub-modules to facilitate comparative research on these topics.

Extended Life Testing of Duplex Ball Bearings

Science.gov (United States)

Mobley, Jeffrey; Robertson, Michael; Hodges, Charles

2016-01-01

Sierra Nevada Corporation’s Space Systems performed bearing life testing for the Scan Mirror Motor/Encoder Assembly (SMMA), part of the Scan Mirror Assembly on-board the Aerosol Polarimetry Sensor (APS) on the NASA Glory Spacecraft. The baseline bearing life test duration extended beyond the launch date for the Glory Spacecraft; a risk that the program was willing to undertake with the understanding that if any anomalies or failures occurred before the required life was achieved, then the mission objectives or operating profile could be modified on orbit to take those results into account. Even though the Glory Spacecraft failed to reach orbit during its launch in March of 2011, the bearing life testing was continued through a mutual understanding of value between Sierra Nevada Corporation and our customer; with a revised goal of testing to failure rather than completing a required number of life cycles. Life testing thus far has not only exceeded the original mission required life, but has also exceeded the published test data for Cumulative Degradation Factor (CDF) from NASA/CR-2009-215681. Many lessons were learned along the way regarding long life testing. The bearing life test has been temporarily suspended due to test support equipment issues.

CCM - Understanding and working with Competencies

CERN Multimedia

HR Department

2011-01-01

Find out what competencies are, make them come to life by sharing your experience with colleagues, and understand what they represent in our work environment. All staff members are encouraged to attend. Register here for sessions in March and April.

Origin and evolution of life on terrestrial planets.

Science.gov (United States)

Brack, A; Horneck, G; Cockell, C S; Bérces, A; Belisheva, N K; Eiroa, Carlos; Henning, Thomas; Herbst, Tom; Kaltenegger, Lisa; Léger, Alain; Liseau, Réne; Lammer, Helmut; Selsis, Franck; Beichman, Charles; Danchi, William; Fridlund, Malcolm; Lunine, Jonathan; Paresce, Francesco; Penny, Alan; Quirrenbach, Andreas; Röttgering, Huub; Schneider, Jean; Stam, Daphne; Tinetti, Giovanna; White, Glenn J

2010-01-01

The ultimate goal of terrestrial planet-finding missions is not only to discover terrestrial exoplanets inside the habitable zone (HZ) of their host stars but also to address the major question as to whether life may have evolved on a habitable Earth-like exoplanet outside our Solar System. We note that the chemical evolution that finally led to the origin of life on Earth must be studied if we hope to understand the principles of how life might evolve on other terrestrial planets in the Universe. This is not just an anthropocentric point of view: the basic ingredients of terrestrial life, that is, reduced carbon-based molecules and liquid H(2)O, have very specific properties. We discuss the origin of life from the chemical evolution of its precursors to the earliest life-forms and the biological implications of the stellar radiation and energetic particle environments. Likewise, the study of the biological evolution that has generated the various life-forms on Earth provides clues toward the understanding of the interconnectedness of life with its environment.

One-Bath Pretreatment for Enhanced Color Yield of Ink-Jet Prints Using Reactive Inks

Directory of Open Access Journals (Sweden)

Wei Ma

2017-11-01

Full Text Available In order to facilely increase the color yield of ink-jet prints using reactive inks, one-bath pretreatment of cotton fabrics with pretreatment formulation containing sodium alginate, glycidyltrimethylammonium chloride (GTA, sodium hydroxide, and urea is designed for realizing sizing and cationization at the same time. The pretreatment conditions, including the concentrations of GTA and alkali, baking temperature, and time are optimized based on the result of thecolor yield on cationic cotton for magenta ink. The mechanism for color yield enhancement on GTA-modified fabrics is discussed and the stability of GTA in the print paste is investigated. Scanning electron microscopey, tear strength, and thermogravimetric analysis of the modified and unmodified cotton are studied and compared. Using the optimal pretreatment conditions, color yield on the cationic cotton for magenta, cyan, yellow, and black reactive inks are increased by 128.7%, 142.5%, 71.0%, and 38.1%, respectively, compared with the corresponding color yield on the uncationized cotton. Much less wastewater is produced using this one-bath pretreatment method. Colorfastness of the reactive dyes on the modified and unmodified cotton is compared and boundary clarity between different colors is evaluated by ink-jet printing of colorful patterns.

Evaluation of flow properties in the weldments of vanadium alloys using a novel indentation technique

Energy Technology Data Exchange (ETDEWEB)

Gubbi, A.N.; Rowcliffe, A.F.; Lee, E.H.; King, J.F.; Goodwin, G.M. [Oak Ridge National Lab., TN (United States)

1996-10-01

Automated Ball Indentation (ABI) testing, was successfully employed to determine the flow properties of the fusion zone, heat affected zone (HAZ), and base metal of the gas tungsten arc (GTA) and electron beam (EB) welds of the V-4Cr-4Ti (large heat no. 832665) and the V-5Cr-5Ti (heat 832394) alloys. ABI test results showed a clear distinction among the properties of the fusion zone, HAZ, and base metal in both GTA and EB welds of the two alloys. GTA and EB welds of both V-4Cr-4Ti and V-5Cr-5Ti alloys show strengthening of both the fusion zone and the HAZ (compared to base metal) with the fusion zone having higher strength than the HAZ. These data correlate well with the Brinell hardness. On the other hand, GTA welds of both alloys, after a post-weld heat treatment of 950{degrees}C for 2 h, show a recovery of the properties to base metal values with V-5Cr-5Ti showing a higher degree of recovery compared to V-4Cr-4Ti. These measurements correlate with the reported recovery of the Charpy impact properties.

Learn new mechanisms from life

International Nuclear Information System (INIS)

Ji Qing; Luo Mingyan; Tong Xiaolin; Zhang Bo; Zhang Hui

2005-01-01

On the basis of the important experimental results of molecular motors, it was pointed out that the moving process of molecular motors is a coupling biological process of chemical-electrical-mechanical processes. This clever mechanism of energy conversion on the molecular level with several processes coupled together had never been observed before. The understanding of this new mechanism is an important step towards the understanding of life and an important content of what we can learn from life. The authors introduced here the status of the investigations on the mechanism for the force generation of kinesin and the studies of the authors in this field. (authors)

Educational Focuses in Organisational Life Cycles.

Science.gov (United States)

Miller, Harry G.

1985-01-01

Presents four stages frequently associated with the stages of an organization's life cycle: experimentation, growth, maturity, and decline or stability. The author also demonstrates that the impact of employment and thus training related to organizational life cycles suggests a need for understanding the technical preparation required for…

The Life of Australian Banknotes

OpenAIRE

Alexandra Rush

2015-01-01

Understanding the life of banknotes is important to a currency issuer's forward planning. Without accurate predictions of banknote life, there is a risk of incurring the economic costs of overproducing and storing excess banknotes or conversely, in an extreme case, of not being able to meet the public's demand. The life of a banknote, however, is not directly observed and must be estimated – a process complicated by the manner in which banknotes are issued and circulated. Often currency issue...

Application of structural reliability and risk assessment to life prediction and life extension decision making

International Nuclear Information System (INIS)

Meyer, T.A.; Balkey, K.R.; Bishop, B.A.

1987-01-01

There can be numerous uncertainties involved in performing component life assessments. In addition, sufficient data may be unavailable to make a useful life prediction. Structural Reliability and Risk Assessment (SRRA) is primarily an analytical methodology or tool that quantifies the impact of uncertainties on the structural life of plant components and can address the lack of data in component life prediction. As a prelude to discussing the technical aspects of SRRA, a brief review of general component life prediction methods is first made so as to better develop an understanding of the role of SRRA in such evaluations. SRRA is then presented as it is applied in component life evaluations with example applications being discussed for both nuclear and non-nuclear components

Life Sciences Space Station planning document: A reference payload for the Life Sciences Research Facility

Science.gov (United States)

1986-01-01

The Space Station, projected for construction in the early 1990s, will be an orbiting, low-gravity, permanently manned facility providing unprecedented opportunities for scientific research. Facilities for Life Sciences research will include a pressurized research laboratory, attached payloads, and platforms which will allow investigators to perform experiments in the crucial areas of Space Medicine, Space Biology, Exobiology, Biospherics and Controlled Ecological Life Support System (CELSS). These studies are designed to determine the consequences of long-term exposure to space conditions, with particular emphasis on assuring the permanent presence of humans in space. The applied and basic research to be performed, using humans, animals, and plants, will increase our understanding of the effects of the space environment on basic life processes. Facilities being planned for remote observations from platforms and attached payloads of biologically important elements and compounds in space and on other planets (Exobiology) will permit exploration of the relationship between the evolution of life and the universe. Space-based, global scale observations of terrestrial biology (Biospherics) will provide data critical for understanding and ultimately managing changes in the Earth's ecosystem. The life sciences community is encouraged to participate in the research potential the Space Station facilities will make possible. This document provides the range and scope of typical life sciences experiments which could be performed within a pressurized laboratory module on Space Station.

The Understanding of libertarianism

Directory of Open Access Journals (Sweden)

Hubert Staśkiewicz

2015-03-01

Full Text Available This scientific article treats of libertarianism. This school of political thought is based on methodological individualism, methodological subjectivism, anti-empiricism, apriorism. Libertarian philosophers demand almost absolute freedom in every area of life and that is why they are at the opposite pole to all totalitarian ideologies. The greatest influence on the understanding of libertarianism had Carl Menger, Murray Rothbard and David Nolan.

[Jaspers and the problem of understanding: a plea for revision].

Science.gov (United States)

Brücher, K

2012-04-01

Understanding (Verstehen), as far as it is discussed explicitly in psychiatry, is based on Dilthey's dichotomy "nature we explain, the life of the soul we understand ( , 144). According to this doctrine, understanding is concerned with a person's inner life and consequently, its method consists in putting oneself in the other's position and reliving their experience. Jaspers' concept of understanding - which is regarded as definitive for psychiatry by advocates and opponents alike - is commonly interpreted according to this tradition as well. I shall argue here that this position does not stand up to scrutiny. It is a mistake to simplify Dilthey's concept of understanding to a form of mere psychologism. In fact, Jaspers practically tore this position down. In his own account, by contrast, he utilises Max Weber and Rickert to established a third realm in addition to a person's inner life on the one hand and their bodily nature on the other: the realm of the objective products of the human mind. It is this dimension that is essential for understanding. Such a transition from the dichotomy of explaining and understanding to a three-valued logic requires a radical rethinking of the traditional notion of understanding. Jaspers meets this demand but he does so only implicitly and not always consistently so that it might easily be missed. It is nonetheless crucial to see that Jaspers in fact rejects the hermeneutics of empathy which are commonly attributed to him and for which he is often criticised. In conclusion of this essay, I will suggest some implications of this - often overlooked - distinction for psychiatry and psychology. © Georg Thieme Verlag KG Stuttgart · New York.

Glutaraldehyde cross-linking of amniotic membranes affects their nanofibrous structures and limbal epithelial cell culture characteristics

Directory of Open Access Journals (Sweden)

Lai JY

2013-10-01

Full Text Available Jui-Yang Lai,1–3 David Hui-Kang Ma4,5 1Institute of Biochemical and Biomedical Engineering, 2Biomedical Engineering Research Center, 3Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan; 4Limbal Stem Cell Laboratory, Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 5Department of Chinese Medicine, Chang Gung University, Taoyuan, Taiwan Abstract: Given that the cells can sense nanometer dimensions, the chemical cross-linking-mediated alteration in fibrillar structure of collagenous tissue scaffolds is critical to determining their cell culture performances. This article explores, for the first time, the effect of nanofibrous structure of glutaraldehyde (GTA cross-linked amniotic membrane (AM on limbal epithelial cell (LEC cultivation. Results of ninhydrin assays demonstrated that the amount of new cross-links formed between the collagen chains is significantly increased with increasing the cross-linking time from 1 to 24 hours. By transmission electron microscopy, the AM treated with GTA for a longer duration exhibited a greater extent of molecular aggregation, thereby leading to a considerable increase in nanofiber diameter and resistance against collagenase degradation. In vitro biocompatibility studies showed that the samples cross-linked with GTA for 24 hours are not well-tolerated by the human corneal epithelial cell cultures. When the treatment duration is less than 6 hours, the biological tissues cross-linked with GTA for a longer time may cause slight reductions in 3-(4,5-dimethylthiazol-2-yl-5-(3-carboxymethoxyphenyl-2-(4-sulfophenyl-2H-tetrazolium, inner salt, and anti-inflammatory activities. Nevertheless, significant collagen molecular aggregation also enhances the stemness gene expression, indicating a high ability of these AM matrices to preserve the progenitors of LECs in vitro. It is concluded that GTA cross-linking of collagenous tissue materials may affect their nanofibrous

Life in the universe: Towards an understanding of its origin

International Nuclear Information System (INIS)

Chela-Flores, J.

1993-05-01

A general review is presented in which we select some aspects of the origin of the cosmos, chemical evolution and, finally, the origin and the evolution of life on Earth. We emphasize the topic of molecular relics with particular attention to the relevance of the chirality of amino acids and nucleic acids. We conclude with a discussion of the primordial RNA world and with some preliminary ideas on the question of whether it is possible to detect relics of the RNA world, other than chirality itself. (author). 27 refs, 4 figs, 2 tabs

Life Course Stage and Social Support Mobilization for End-of-Life Caregivers.

Science.gov (United States)

LaValley, Susan A; Gage-Bouchard, Elizabeth A

2018-04-01

Caregivers of terminally ill patients are at risk for anxiety, depression, and social isolation. Social support from friends, family members, neighbors, and health care professionals can potentially prevent or mitigate caregiver strain. While previous research documents the importance of social support in helping end-of-life caregivers cope with caregiving demands, little is known about differences in social support experiences among caregivers at different life course stages. Using life course theory, this study analyzes data from in-depth interviews with 50 caregivers of patients enrolled in hospice services to compare barriers to mobilizing social support among caregivers at two life course stages: midlife caregivers caring for parents and older adult caregivers caring for spouses/partners. Older adult caregivers reported different barriers to mobilizing social support compared with midlife caregivers. Findings enhance the understanding of how caregivers' life course stage affects their barriers to mobilization of social support resources.

Teaching assistant-student interactions in a modified SCALE-UP classroom

Science.gov (United States)

DeBeck, George; Demaree, Dedra

2012-02-01

In the spring term of 2010, Oregon State University (OSU) began using a SCALE-UP style classroom in the instruction of the introductory calculus-based physics series. Instruction in this classroom was conducted in weekly two-hour sessions facilitated by the primary professor and either two graduate teaching assistants (GTAs) or a graduate teaching assistant and an undergraduate learning assistant (LA). During the course of instruction, two of the eight tables in the room were audio and video recorded. We examine the practices of the GTAs in interacting with the students through both qualitative and quantitative analyses of these recordings. Quantitatively, significant differences are seen between the most experienced GTA and the rest. A major difference in confidence is also observed in the qualitative analysis of this GTA compared to a less experienced GTA.

Reconceptualizing Agency within the Life Course: The Power of Looking Ahead1

Science.gov (United States)

Hitlin, Steven; Johnson, Monica Kirkpatrick

2015-01-01

Empirical treatments of agency have not caught up with theoretical explication; empirical projects almost always focus on concurrent beliefs about one’s ability to act successfully without sufficiently attending to temporality. We suggest that understanding the modern life course necessitates a multidimensional understanding of subjective agency involving a) perceived capacities and b) perceived life-chances, or expectations about what life holds in store. We also suggest that a proper understanding of agency’s potential power within a life course necessitates moving beyond the domain-specific expectations more typical of past sociological work. Utilizing the Youth Development Study (YDS), we employ a scale of general life expectations in adolescence to explore the potential influence of a general sense of optimistic life-expectations in addition to the traditional agency-as-efficacy approach on a range of important outcomes. PMID:26166833

Functional Linkages for the Pace of Life, Life-history, and Environment in Birds

OpenAIRE

Williams, Joseph B.; Miller, Richard A.; Harper, James M.; Wiersma, Popko

2010-01-01

For vertebrates, body mass underlies much of the variation in metabolism, but among animals of the same body mass, metabolism varies six-fold. Understanding how natural selection can influence variation in metabolism remains a central focus of Physiological Ecologists. Life-history theory postulates that many physiological traits, such as metabolism, may be understood in terms of key maturational and reproductive characteristics over an organism’s life-span. Although it is widely acknowledged...

End-of-life decisions: Christian perspectives.

Science.gov (United States)

Stempsey, William E

1997-12-01

While legal rights to make medical treatment decisions at the end of one's life have been recognized by the courts, particular religious traditions put axiological and metaphysical meat on the bare bones of legal rights. Mere legal rights do not capture the full reality, meaning and importance of death. End-of-life decisions reflect not only the meaning we find in dying, but also the meaning we have found in living. The Christian religions bring particular understandings of the vision of life as a gift from God, human responsibility for stewardship of that life, the wholeness of the person, and the importance of the dying process in preparing spiritually for life beyond earthly life, to bear on end-of-life decisions.

The Christian Understanding of Happiness

Directory of Open Access Journals (Sweden)

Andrzej Zwoliński

2016-04-01

Full Text Available The relationship with God allows man to find the sense of life. Christianity is a humanism – it positions man in the very centre of the world according him the highest place – of the being created after God’s image. The revelation of God’s Love endows man with a new way of enriching himself and others. Thus the desire for happiness gains a new perspective of the divine longing for good. Happiness which Christ promises exceeds the limits of our imagination. It is incon­ ceivable and incomprehensible to those living on earth. Heaven is beyond every word, beyond our conception for it bears the meaning which man cannot fully understand. It is the most supreme happiness, absolutely perfect and complete which no one has ever known. A Christian has to achieve in his life something more than the worldly aims. Whoever limits their life to the earth, focuses only on enjoying and using this life to the full; squeezing from it the last drop heedless of the needs of others.

Product Life Design: Notes for course 41627

DEFF Research Database (Denmark)

McAloone, Timothy Charles; Andreasen, Mogens Myrup

2003-01-01

- and ecological specifications, life cycle-oriented quality, whole life costs. - Product life systems, "the meeting", relational properties, the role of the human operator. - Modelling of the product and the product life cycle, computer modelling. - The score model, Integrated Product Development, Life Cycle...... Engineering, Concurrent Engineering. - The importance of the product concept, explicit life phase concepts. - Modelling of meetings, "universal virtues", simulation. - Product modelling, Product Data Management, life cycle databases, design history, documentation. - The structure and the content of the DFX......The course in product life design is designed to give an understanding of the phenomena of life cycle and product life thinking, the role of product design in fitting to product life systems and thus achieving sound product life perspectives. The course aims at developing an ability in the student...

The Dynamics of Life Skills Coaching.

Science.gov (United States)

Saskatchewan NewStart, Inc., Prince Albert.

This book is used throughout the life skills coach training course. The content focuses on increasing the understanding the training material and to assist in coaching life skills students. The course, based on adult training and counseling methods, involves the development of problem-solving behaviors in the management of personal affairs. The…

Family perceptions of intellectual disability: Understanding and support in Dar es Salaam

Science.gov (United States)

2012-01-01

When attempting to understand the construct of intellectual disability in different contexts, speaking to family members in addition to the individual with the disability may provide new insight about understandings of and responses to intellectual disability in society and may help to identify the forms of support that are available or needed to ensure the quality of life of people with disabilities. This article outlines and discusses interviews that were conducted in Dar es Salaam, Tanzania, with family members of children and adults with intellectual disabilities. These interviews explore how families came to understand that their child had an intellectual disability; the availability of family support; and family hopes and dreams for the future, and were a part of a wider exploratory study that gathered insight from individuals with disabilities, families, and other providers of support to explore understandings and perceptions of disability in Dar es Salaam. Understanding family experiences will help researchers, policy makers, non-governmental organisations, and others to identify family strengths and family support needs which can ultimately improve family quality of life and the quality of life of the member with a disability. PMID:28729979

Understanding, preventing urban violence in Kinshasa | IDRC ...

International Development Research Centre (IDRC) Digital Library (Canada)

2015-11-05

Nov 5, 2015 ... ... are exploring the underlying dynamics of life in the capital city and analyzing how they ... poverty, and inequality that holds the key to understanding the links between ... Social cohesion: solution or driver of urban violence?

Media life of the young

DEFF Research Database (Denmark)

Westlund, Oscar; Bjur, Jakob

2014-01-01

This is a thorough investigation into contemporary young people and their media life. The article conceptualizes a typology of media life, drawing on a theoretical body involving the sociology of generations, life course research, media life and individualization. This empirically derived typology...... makes a strong instrument for an understanding of the media life of the young, furnishing insights into how they have constructed their use of media. The investigation is based on a robust national survey with Swedes born 1994–2001, conducted in 2010, and focusing on four media: television, gaming......, the Internet and mobile devices. Two of the findings are particularly surprising. Firstly, the results reveal that the young generally lead heterogeneous media lives, varying with age and sex. Secondly, although some young people literarily live their life in media, there are also de facto young who live...

The impact of hyperhidrosis on patients' daily life and quality of life: a qualitative investigation.

Science.gov (United States)

Kamudoni, P; Mueller, B; Halford, J; Schouveller, A; Stacey, B; Salek, M S

2017-06-08

An understanding of the daily life impacts of hyperhidrosis and how patients deal with them, based on qualitative research, is lacking. This study investigated the impact of hyperhidrosis on the daily life of patients using a mix of qualitative research methods. Participants were recruited through hyperhidrosis patient support groups such as the Hyperhidrosis Support Group UK. Data were collected using focus groups, interviews and online surveys. A grounded theory approach was used in the analysis of data transcripts. Data were collected from 71 participants, out of an initial 100 individuals recruited. Seventeen major themes capturing the impacts of hyperhidrosis were identified; these covered all areas of life including daily life, psychological well-being, social life, professional /school life, dealing with hyperhidrosis, unmet health care needs and physical impact. Psychosocial impacts are central to the overall impacts of hyperhidrosis, cutting across and underlying the limitations experienced in other areas of life.

Remodelling the Life Course: Making the Most of Life with Multiple Sclerosis

Directory of Open Access Journals (Sweden)

Milka Satinovic

2017-06-01

Full Text Available The aim of the study was to develop a substantive grounded theory on how to live a life as good as possible with multiple sclerosis (MS. The question of how to improve the quality of life is of key importance when speaking of a chronic illness like MS. We still have little knowledge of this important question from the patients’ perspective. Classic grounded theory was used to explore patients’ experiences of living with MS. The aim was to identify their main concern and how they process this concern at different phases in their life course. Twenty-one interviews were conducted with 17 participants diagnosed with multiple sclerosis. Participant observation at five courses for people with a multiple sclerosis diagnosis generated field notes. The participants’ main concern was how to live a life as good as possible in spite of their deteriorating health. The participants met this challenge through a process of remodelling the life course, in four phases: postponing (keeping up a normal life, adjusting (moving on to a changed life, restructuring (doing the best of it in a changed life, and transforming (preventing illness from controlling life. The remodelling process is influenced by the individual context, like the current health situation, biography, relations, and structural conditions. The process of remodelling helps us understand what facilitates and what hinders patients with MS from living a good life.

Environmental effects on growth, reproduction, and life-history traits of loggerhead turtles

NARCIS (Netherlands)

Marn, Nina; Jusup, Marko; Legović, Tarzan; Kooijman, S. A.L.M.; Klanjšček, Tin

2017-01-01

Understanding the relationship between the environmental conditions and life-history traits (such as growth, reproduction, and size at specific life stages) is important for understanding the population dynamics of a species and for constructing adaptable, relevant, and efficient conservation

Constructing an Interdisciplinary Context for Definition of Life

Science.gov (United States)

Tsokolov, S. A.

One of the main problems in understanding life is that that lifecannot be defined as a self-evident phenomenon. Instead, definitions of life inevitably depend on the context: social, ethical, theological, and scientific. Even in a purely scientific context, different scientific disciplines and approaches provide a variety of criteria related to life. My intention is to define life in an interdisciplinary context, where the class of living systems can be presented as a particular case in series of systems: physical, chemical, prebiotic, biotic, ecological, social, cognitive, etc. related by a universal principle. To this end, the first step in establishing general criteria for life is to define the essential features of life processes. The very functional principle of living beings is circular organization (feedback circularity) embedded on different levels of organization: molecular, genetic, cellular, neural, behavioural, mental, and social. Understanding that the degree of system's wholeness, i.e. degree of feedback net integration can serve as a primary parameter, we can in principle construct an interdisciplinary context in which different systems including living beings can be analyzed, defined and compared.

Influence of nitrogen in the shielding gas on corrosion resistance of duplex stainless steel welds

Science.gov (United States)

Bhatt, R. B.; Kamat, H. S.; Ghosal, S. K.; de, P. K.

1999-10-01

The influence of nitrogen in shielding gas on the corrosion resistance of welds of a duplex stainless steel (grade U-50), obtained by gas tungsten arc (GTA) with filler wire, autogenous GTA (bead-on-plate), electron beam welding (EBW), and microplasma techniques, has been evaluated in chloride solutions at 30 °C. Pitting attack has been observed in GTA, electron beam welding, and microplasma welds when welding has been carried out using pure argon as the shielding gas. Gas tungsten arc welding with 5 to 10% nitrogen and 90 to 95% argon, as the shielding gas, has been found to result in an improved pitting corrosion resistance of the weldments of this steel. However, the resistance to pitting of autogenous welds (bead-on-plate) obtained in pure argon as the shielding gas has been observed to remain unaffected. Microscopic examination, electron probe microanalysis (EPMA), and x-ray diffraction studies have revealed that the presence of nitrogen in the shielding gas in the GTA welds not only modifies the microstructure and the austenite to ferrite ratio but also results in a nearly uniform distribution of the various alloying elements, for example, chromium, nickel, and molybdenum among the constitutent phases, which are responsible for improved resistance to pitting corrosion.

Life-history interviews

DEFF Research Database (Denmark)

Adriansen, Hanne Kirstine

2010-01-01

in qualitative interviews. I first presented the paper on a conference on life history research at Karlstad University in November 2010. My main purpose was to establish whether a paper discussing the use of time line interviews should be placed in the context of a life history research. The valuable comments......My first encounter with life history research was during my Ph.D. research. This concerned a multi-method study of nomadic mobility in Senegal. One method stood out as yielding the most interesting and in-depth data: life story interviews using a time line. I made interviews with the head...... of the nomadic households and during these I came to understand the use of mobility in a complex context of continuity and change, identity and belonging in the Fulani community. Time line interviews became one of my favourite tool in the years to follow, a tool used both for my research in various settings...

The Academic Life: Small Worlds, Different Worlds

Science.gov (United States)

Locke, William

2010-01-01

"The Academic Life: Small Worlds, Different Worlds" represented an impressive investigation of the largest and most complex national academic community in the world, which seriously attempted a detailed representation of the variations in its form. Its ethnographic orientation to understanding the internal academic life through exploratory…

Life with osteoporosis

DEFF Research Database (Denmark)

Hansen, Carrinna

Background: Osteoporosis is considered a major worldwide public health problem. Men and women with osteoporosis are mostly unaware of the illness, until bone fractures occur. It is estimated that more than one in three European women and one in five men over 50 years will experience osteoporotic...... fractures followed by considerable morbidity and mortality. In line with many other chronic illnesses, one of the pronounced challenges related to osteoporosis is considered to be compliance and persistence to medical treatment. The causes of low compliance and persistence to treatment remain unclear....... Living with a chronic illness often affects the entire human life situation, specifically, emotionally and existentially. How this is experienced personally and how this affects the individual’s life is still unknown. Aim: To gain a deeper understanding of patients’ life with osteoporosis by determining...

Understanding the life of illness: learning through the art of Frida Kahlo.

Science.gov (United States)

Darbyshire, P

1994-09-01

That nursing is an art as well as a science is in danger of becoming a cliché unless attempts are made to reverse the marginalization and exclusion of arts and humanities within nursing. An educational approach to promoting more esthetic and less instrumental thinking and understanding is described. This approach enables nurses to gain a deeper understanding of the lived experiences of suffering, chronic pain, miscarriage, and disability through engaging with the art of Mexican painter Frida Kahlo.

Understanding critical factors for the quality and shelf-life of MAP fresh meat: a review.

Science.gov (United States)

Singh, Preeti; Wani, Ali Abas; Saengerlaub, Sven; Langowski, Horst-Christian

2011-02-01

Due to increased demands for greater stringency in relation to hygiene and safety issues associated with fresh food products, coupled with ever-increasing demands by retailers for cost-effective extensions to product shelf-lives and the requirement to meet consumer expectations in relation to convenience and quality, the food packaging industry has rapidly developed to meet and satisfy expectations. One of the areas of research that has shown promise, and had success, is modified atmosphere packaging (MAP). The success of MAP-fresh meat depends on many factors including good initial product quality, good hygiene from the source plants, correct packaging material selection, the appropriate gas mix for the product, reliable packaging equipment, and maintenance of controlled temperatures and humidity levels. Advances in plastic materials and equipment have propelled advances in MAP, but other technological and logistical considerations are needed for successful MAP systems for raw chilled meat. Although several parameters critical for the quality of MA packed meat have been studied and each found to be crucial, understanding of the interactions between the parameters is needed. This review was undertaken to present the most comprehensive and current overview of the widely available, scattered information about the various integrated critical factors responsible for the quality and shelf life of MA packed meat with an interest to stimulate further research to optimize different quality parameters.

Luxury Experiences over the Life Course

DEFF Research Database (Denmark)

von Wallpach, Sylvia; Bauer, Martina; Hemetsberger, Andrea

2014-01-01

This study adopts a life course perspective to broaden our current understanding of the complex nature of consumer luxury experiences. Narrative biographical interviews with members of Generation Y elicit how luxury experiences over the life course relate to significant individual life events...... and illuminate how the macro- and micro-environment bring about changes in Generation Y’s luxury experiences. Essentially, luxury experiences relate to changes in the technological, social, economic, cultural, and individual environment. Our findings have important implications for luxury brand managers...

Quality of life and philosophy of life determines physical and mental health: status over research findings from the Quality of Life Research Center, Copenhagen, 1991-2007.

Science.gov (United States)

Ventegodt, Søren; Kandel, Isack; Merrick, Joav

2007-10-22

Quality of life (QOL) has over the past decade become an important part of health science and also increased public awareness. It has become increasingly apparent that illness is closely related to the individual perception of a good life, and therefore the exploration of indicators related to quality of life appears to be of broad importance for the prevention and treatment of diseases. Identifying, which factors constitute a good life may reveal an understanding about what areas in life should be encouraged, in order to enhance the global quality of life, health, and ability. In this paper we present results from studies initiated in 1989 to examine quality of life in relation to disease. The purpose of this presentation was to assemble the results from the study carried out in the years between 1993 and 1997, examining a total of 11,500 Danes, to show the association between quality of life and a wide series of social indicators.

Creativity for people in vulnerable life situations: Emerging understandings

DEFF Research Database (Denmark)

Hansen, Bodil Winther; la Cour, Karen; Pedersen, Helle Andrea

From an occupational science perspective human life and existence takes place though the doing of activity such creative activity. According to Schmid creativity involves “the capacity to think and act in original ways, to be inventive, to be imagina¬tive and to find new and original solutions.......J Occup Sci 20. 2004;11(2):51-7. 21. Dickie VA, Frank G.Artisan occupations in the global economy: a conceptual framework.J Occup Sci 1996;3(2):45-55. 22. Sundt EL.Om husfliden i Norge.København: Gyldendal; 1975. 23. Dewey J.Experience and education.New York, NY: The Macmillan Company; 1938. 24. Wenger E...... transplant patient experiences participating in art making and music listening.Eur J Oncol Nurs 2016;22:71-7. 28. la Cour K, Josephsson S, Tishelman C et al.Experiences of engagement in cre¬ative activity at a palliative care 29. facility.Palliat Support Care 2007;5(3):241-50. 30. la Cour K, Johannessen H...

Fighting for Dear Life: Christians and Aggressive End-of-Life Care.

Science.gov (United States)

Shinall, Myrick C

2014-01-01

Patients or their family members sometimes give religious reasons for requesting life-sustaining technologies that have little hope of restoring health. This poses an ethical challenge for clinicians and a potential strain on limited health-care resources. Among Christians, one explanation for a preference for aggressive, life-prolonging care is the influence of the idea of martyrdom, which became the normative form of dying in early Christianity. The ancient discourse of martyrdom and the modern discourse of aggressive medical care both share a martial orientation and commend an ethos of combat. This paper examines ancient Christian martyrdom discourse to illuminate its affinity with the discourse of aggressive medical care. The ethos of martyrdom has shaped Christian attitudes toward death such that preference for aggressive medical care at the end of life is understandable.

The origami of life

Energy Technology Data Exchange (ETDEWEB)

Lezon, Timothy R [Department of Physics, 104 Davey Laboratory, Pennsylvania State University, University Park, PA 16802 (United States); Banavar, Jayanth R [Department of Physics, 104 Davey Laboratory, Pennsylvania State University, University Park, PA 16802 (United States); Maritan, Amos [Dipartimento di Fisica ' G Galilei' and INFN, Universita di Padova, Via Marzolo 8, 35131 Padova (Italy)

2006-01-25

All living organisms rely upon networks of molecular interactions to carry out their vital processes. In order for a molecular system to display the properties of life, its constituent molecules must themselves be endowed with several features: stability, specificity, self-organization, functionality, sensitivity, robustness, diversity and adaptability. We argue that these are the emergent properties of a unique phase of matter, and we demonstrate that proteins, the functional molecules of terrestrial life, are perfectly suited to this phase. We explore, through an understanding of this phase of matter, the physical principles that govern the operation of living matter. Our work has implications for the design of functionally useful nanoscale devices and the ultimate development of physically based artificial life.

The origami of life

International Nuclear Information System (INIS)

Lezon, Timothy R; Banavar, Jayanth R; Maritan, Amos

2006-01-01

All living organisms rely upon networks of molecular interactions to carry out their vital processes. In order for a molecular system to display the properties of life, its constituent molecules must themselves be endowed with several features: stability, specificity, self-organization, functionality, sensitivity, robustness, diversity and adaptability. We argue that these are the emergent properties of a unique phase of matter, and we demonstrate that proteins, the functional molecules of terrestrial life, are perfectly suited to this phase. We explore, through an understanding of this phase of matter, the physical principles that govern the operation of living matter. Our work has implications for the design of functionally useful nanoscale devices and the ultimate development of physically based artificial life

Meaning of life in adulthood and later life / Sentido de vida na fase adulta e velhice

Directory of Open Access Journals (Sweden)

Cinara Sommerhalder

2010-01-01

Full Text Available The unceasing search for meaning to life is part of the existential questioning. Viktor Frankl is a pioneer in this field. Later, researchers have used his lessons to expand the definition of the construct 'meaning of life'. Transcultural studies lead to a better understanding of this theme, but further research still needs to be done. The available instruments are being tested and improved; however, we already have relevant information on the theme, and it contributes largely to the study of the development of adulthood and later life. This article aims at showing the evolution of the concept 'meaning of life' and how researches have been dealing with the theme in the field of adulthood and later life development.

Towards understanding how surface life can affect interior geological processes: a non-equilibrium thermodynamics approach

Directory of Open Access Journals (Sweden)

J. G. Dyke

2011-06-01

Full Text Available Life has significantly altered the Earth's atmosphere, oceans and crust. To what extent has it also affected interior geological processes? To address this question, three models of geological processes are formulated: mantle convection, continental crust uplift and erosion and oceanic crust recycling. These processes are characterised as non-equilibrium thermodynamic systems. Their states of disequilibrium are maintained by the power generated from the dissipation of energy from the interior of the Earth. Altering the thickness of continental crust via weathering and erosion affects the upper mantle temperature which leads to changes in rates of oceanic crust recycling and consequently rates of outgassing of carbon dioxide into the atmosphere. Estimates for the power generated by various elements in the Earth system are shown. This includes, inter alia, surface life generation of 264 TW of power, much greater than those of geological processes such as mantle convection at 12 TW. This high power results from life's ability to harvest energy directly from the sun. Life need only utilise a small fraction of the generated free chemical energy for geochemical transformations at the surface, such as affecting rates of weathering and erosion of continental rocks, in order to affect interior, geological processes. Consequently when assessing the effects of life on Earth, and potentially any planet with a significant biosphere, dynamical models may be required that better capture the coupled nature of biologically-mediated surface and interior processes.

Quality of life in the contemporary politics of healthcare: … but what is a life?

Science.gov (United States)

Phillips, Catherine R

2018-03-01

'Quality of life' (QoL) is a ubiquitous phrase in medicine. There is considerable literature on the meaning of 'quality' in 'quality of life', but little on the meaning of 'life'. And yet, rooted in measurements of QoL, is a conceptualization of 'a life' used to judge 'quality'. In this article I focus on 'life' within institutional healthcare, arguing that for patients who are considered elderly, their life is defined against functionality. I use an autoethnographic method to enter this conversation, underlining the disjuncture between patients' understanding of 'a life', and that of healthcare professionals. I draw on the writings of the Italian philosopher Georgio Agamben to interrogate 'life', shifting the conversation of QoL from one of measurement and administration to one of political order. I discuss both the formal, evidence-based tools and the nature of their application. I conclude by arguing that QoL tools and their application, produce a particular kind of life, and that what is at stake in the invocation of 'quality of life' in health care is our very experience of aging and our embodiment. Copyright © 2017 Elsevier Inc. All rights reserved.

Game prototype for understanding safety issues of life boat launching process.

OpenAIRE

Jiang, Min; Chang, Jian; Dodwell, M.; Jekins, J.; Yang, H.J.; Zhang, Jian J.

2016-01-01

Novel advanced game techniques provide us with new possibilities to mimic a complicated training process, with the benefit of safety enhancement. In this paper, we design and implement a 3D game which imitates the lifeboat launching process. Lifeboat launching is such a complex but vital process which can on one side saving people's life on sea and on the other side associating many potential hazards. It involves both the tractor manoeuvres and boat operations. The primary objective of the ga...

Microbial genomes: Blueprints for life

Energy Technology Data Exchange (ETDEWEB)

Relman, David A.; Strauss, Evelyn

2000-12-31

Complete microbial genome sequences hold the promise of profound new insights into microbial pathogenesis, evolution, diagnostics, and therapeutics. From these insights will come a new foundation for understanding the evolution of single-celled life, as well as the evolution of more complex life forms. This report is an in-depth analysis of scientific issues that provides recommendations and will be widely disseminated to the scientific community, federal agencies, industry and the public.

Perceptions of Parental Awareness of Emotional Responses to Stressful Life Events.

Science.gov (United States)

Jobe-Shields, Lisa; Parra, Gilbert R; Buckholdt, Kelly E

2013-10-01

There is a need to better understand family processes related to recovery from past stressful life events. The present study aimed to investigate links between perceptions of parental awareness regarding stressful life events, continued event-related rumination, and current symptoms of depression. Students at a diverse, urban university completed a life events checklist and a semi-structured interview regarding family processing of stressful life events, as well as self-report measures of event-related rumination and depression. Results indicated that perceptions of mothers' and fathers' awareness of sadness regarding stressful life events as well as mothers' and fathers' verbal event processing predicted symptoms of event-related rumination and depression. Results support the inclusion of perceptions of parental awareness in the understanding of how emerging adults continue to cope with past stressful life events.

Quality of life philosophy II: what is a human being?

Science.gov (United States)

Ventegodt, Søren; Andersen, Niels Jørgen; Kromann, Maximilian; Merrick, Joav

2003-12-01

The human being is a complex matter and many believe that just trying to understand life and what it means to be human is a futile undertaking. We believe that we have to try to understand life and get a grip on the many faces of life, because it can be of great value to us to learn to recognize the fundamental principles of how life is lived to the fullest. Learning to recognize the good and evil forces of life helps us to make use of the good ones. To be human is to balance between hundreds of extremes. Sometimes we have to avoid these extremes, but at other times it seems we should pursue them, to better understand life. With our roots in medicine, we believe in the importance of love for better health. The secret of the heart is when reason and feelings meet and we become whole. Where reason is balanced perfectly by feelings and where mind and body come together in perfect unity, a whole new quality emerges, a quality that is neither feeling nor reason, but something deeper and more complete. In this paper, we outline only enough biology to clarify what the fundamental inner conflicts are about. The insight into these conflicts gives us the key to a great deal of the problems of life. To imagine pleasures greater than sensual pleasures seems impossible to most people. What could such a joy possibly be? But somewhere deep in life exists the finest sweetness, the greatest quality in life, the pure joy of being alive that emerges when we are fully present and life is in balance. This deep joy of life is what we call experiencing the meaning of life.

Quality of Life Philosophy II: What is a Human Being?

Directory of Open Access Journals (Sweden)

Søren Ventegodt

2003-01-01

Full Text Available The human being is a complex matter and many believe that just trying to understand life and what it means to be human is a futile undertaking. We believe that we have to try to understand life and get a grip on the many faces of life, because it can be of great value to us to learn to recognize the fundamental principles of how life is lived to the fullest. Learning to recognize the good and evil forces of life helps us to make use of the good ones.To be human is to balance between hundreds of extremes. Sometimes we have to avoid these extremes, but at other times it seems we should pursue them, to better understand life. With our roots in medicine, we believe in the importance of love for better health. The secret of the heart is when reason and feelings meet and we become whole. Where reason is balanced perfectly by feelings and where mind and body come together in perfect unity, a whole new quality emerges, a quality that is neither feeling nor reason, but something deeper and more complete.In this paper, we outline only enough biology to clarify what the fundamental inner conflicts are about. The insight into these conflicts gives us the key to a great deal of the problems of life. To imagine pleasures greater than sensual pleasures seems impossible to most people. What could such a joy possibly be? But somewhere deep in life exists the finest sweetness, the greatest quality in life, the pure joy of being alive that emerges when we are fully present and life is in balance. This deep joy of life is what we call experiencing the meaning of life.

Using life story work to enhance care.

Science.gov (United States)

Thompson, Rachel

2011-10-01

Life story work has been promoted as a tool to enhance the care provided to older people, particularly those with dementia. The benefits for individuals, families and/or friends and for staff include improving understanding of the individual, promoting relationships and assisting in the delivery of person-centred care. However, professionals often experience difficulties using life story work. This article considers a range of life story tools and advice on gathering information about a person. It highlights the importance of leadership and developing positive cultures to ensure that life story work can be effectively sustained.

Understanding the life cycle surface land requirements of natural gas-fired electricity

Science.gov (United States)

Jordaan, Sarah M.; Heath, Garvin A.; Macknick, Jordan; Bush, Brian W.; Mohammadi, Ehsan; Ben-Horin, Dan; Urrea, Victoria; Marceau, Danielle

2017-10-01

The surface land use of fossil fuel acquisition and utilization has not been well characterized, inhibiting consistent comparisons of different electricity generation technologies. Here we present a method for robust estimation of the life cycle land use of electricity generated from natural gas through a case study that includes inventories of infrastructure, satellite imagery and well-level production. Approximately 500 sites in the Barnett Shale of Texas were sampled across five life cycle stages (production, gathering, processing, transmission and power generation). Total land use (0.62 m2 MWh-1, 95% confidence intervals ±0.01 m2 MWh-1) was dominated by midstream infrastructure, particularly pipelines (74%). Our results were sensitive to power plant heat rate (85-190% of the base case), facility lifetime (89-169%), number of wells per site (16-100%), well lifetime (92-154%) and pipeline right of way (58-142%). When replicated for other gas-producing regions and different fuels, our approach offers a route to enable empirically grounded comparisons of the land footprint of energy choices.

Using Pipe Cleaners to Bring the Tree of Life to Life

Science.gov (United States)

Halverson, Kristy L.

2010-01-01

Phylogenetic trees, such as the "Tree of Life," are commonly found in biology textbooks and are often used in teaching. Because students often struggle to understand these diagrams, I developed a simple, inexpensive classroom model. Made of pipe cleaners, it is easily manipulated to rotate branches, compare topologies, map complete lineages,…

Life into Space: Space Life Sciences Experiments, Ames Research Center, Kennedy Space Center, 1991-1998, Including Profiles of 1996-1998 Experiments

Science.gov (United States)

Souza, Kenneth (Editor); Etheridge, Guy (Editor); Callahan, Paul X. (Editor)

2000-01-01

We have now conducted space life sciences research for more than four decades. The continuing interest in studying the way living systems function in space derives from two main benefits of that research. First, in order for humans to engage in long-term space travel, we must understand and develop measures to counteract the most detrimental effects of space flight on biological systems. Problems in returning to the conditions of Earth must be kept to a manageable level. Second, increasing our understanding of how organisms function in the absence of gravity gives us new understanding of fundamental biological processes. This information can be used to improve human health and the quality of life on Earth.

Life without Work: Understanding Social Class Changes and Unemployment through Theoretical Integration

Science.gov (United States)

Ali, Saba Rasheed; Fall, Kevin; Hoffman, Tina

2013-01-01

Unemployment is a stark reality in today's economic climate, and many Americans report a fear of loss or decrease in social status as a result of unexpected unemployment. Despite vocational psychology's emphasis on work as a domain of life, very little exploration on how social class shifts impact workers has been conducted. One way to rectify the…

The importance of understanding military culture.

Science.gov (United States)

Hall, Lynn K

2011-01-01

Social workers can make a significant contribution to military service members and their families, but first it is essential that the worldview, the mindset, and the historical perspective of life in the military are understood. Unless we understand how the unique characteristics of the military impact the service members and their families, we cannot work effectively with them. In addition, unless we understand their language, their structure, why they join, their commitment to the mission, and the role of honor and sacrifice in military service, we will not be able to adequately intervene and offer care to these families.

Psychologica and social adjustment to blindness: Understanding ...

African Journals Online (AJOL)

Psychologica and social adjustment to blindness: Understanding from two groups of blind people in Ilorin, Nigeria. ... Background: Blindness can cause psychosocial distress leading to maladjustment if not mitigated. Maladjustment is a secondary burden that further reduces quality of life of the blind. Adjustment is often ...

Synthetic Biology and the Search for Extraterrestrial Life

Science.gov (United States)

Rothschild, Lynn J.

2015-01-01

"Are we alone?" is one of the primary questions of astrobiology, and whose answer defines our significance in the universe. Unfortunately, this quest is hindered by the fact that we have only one confirmed example of life, that of earth. While this is enormously helpful in helping to define the minimum envelope for life, it strains credulity to imagine that life, if it arose multiple times, has not taken other routes. To help fill this gap, our lab has begun using synthetic biology - the design and construction of new biological parts and systems and the redesign of existing ones for useful purposes - as an enabling technology. One theme, the "Hell Cell" project, focuses on creating artificial extremophiles in order to push the limits for Earth life, and to understand how difficult it is for life to evolve into extreme niches. In another project, we are re-evolving biotic functions using only the most thermodynamically stable amino acids in order to understand potential capabilities of an early organism with a limited repertoire of amino acids.

Training Graduate Teaching Assistants in the Geosciences: Our Practices vs. Perceived Needs

Science.gov (United States)

Teasdale, R.; Ryker, K.; Bitting, K. S.

2016-12-01

Graduate Teaching Assistants (GTAs) in the geosciences are responsible for teaching a large proportion of undergraduate students in many universities. Often, GTAs are primary instructors in small laboratory sections of large enrollment courses, putting them in the position of having a more personalized relationship with students, in what is often the most interactive portion of an introductory course. Anecdotally, geoscientists recognize that GTAs also have a broad range of responsibilities, but there is wide variation in the content and timing of the training they receive. Until now, no comprehensive survey has been conducted to capture and analyze this distribution in a systematic way. Data from a nationwide survey of 120 geoscientists is used here to characterize the ways GTAs are trained as well as respondents' priorities for GTA training. Respondents include faculty from PhD- and MS- granting institutions (81.4%) and MS-only granting institutions (18.5%). According to the survey, most GTAs teach laboratory sections (95.6%), and many teach lecture sections (38.9%). In many cases, GTAs support instructors during or outside of the "lecture" section (e.g. grading, 77.1%). Of GTAs who teach lecture or lab sections, most receive required training from their department or the university, commonly on a single day just before the start of the semester. GTA training typically includes logistical information (where to find materials, professionalism), but less than 40% of GTAs are required to participate in pedagogical training. In contrast, pedagogy was most often rated very important or important (74.2%) by survey respondents. The disconnect between the geoscience community's current practices in GTA training and our current values suggests that GTA training programs are needed, and that the community can benefit from reports on the success of existing programs and the dissemination of adaptable models for GTA pedagogical training.

Inner and Outer Life at Work. The Roots and Horizon of Psychoanalytically Informed Work Life Research

DEFF Research Database (Denmark)

Lundgaard Andersen, Linda

2013-01-01

identities, conflicts, organisational and societal structuration. Against this background the accounts and conceptualisations of work life involving people to people interactions offered by psychodynamic theories and methods take up a pivotal position. Psychoanalytic organisational and work life research...... of personalised competences and work investments in welfare services, the transformation from subject-object relationships to subject-subject relationships and the emergence of the "learning organisations" and reflexive leadership. All of this has been the subject of critical analyses tracing modern work life...... position and German psychoanalytic social psychology in order to situate and identify how to understand the inner and outer life at work – in a generic display of concepts, methods and epistemology....

UNDERSTANDING RESIDENT’ ACTIVITY SYSTEM-IMPROVING QUALITY LIFE: A CASE STUDY OF DOME POST DISASTER SETTLEMENT IN NGELEPEN SLEMAN, YOGYAKARTA

Directory of Open Access Journals (Sweden)

SYAM Rachma Marcillia

2016-12-01

Full Text Available House is not only functioning as a place for shelter, but also for accommodating personal and social activities of its inhabitants. Unfortunately in post quake disaster dome houses Ngelepen, Yogyakarta, the majority of the early settlers must change their behavior and habits that they used to do in their previous environment to adjust the new settlement. These happened because dome housing did not facilitate some activities whether personal or social activities within the house, therefore the activities extended to the outside of the house or even the surrounding environment. This study aims to understand the system activities on the dome house settlement Yogyakarta. In order to get detailed description, quantitative as well as qualitative approach was done through observation of the activities type, when and where the activities conducted. Data collection was done by continuous place centered behavior mapping to know how the occupants use and accommodate their behavior in certain time and specific place. The results of this study showed that daily activities on weekdays and holidays conducted by different group; children, adult and elderly, at different areas and for different type of activities in certain times. The pathways and courtyard of the house mostly used for domestic household activities and leisure as an extension of the social interaction space. In understanding the system activities that occurred, it is expected that this study can contribute to improve the quality of life of people live in a relocation settlement.

Understanding Intellectual Disability through Rasopathies

OpenAIRE

Alvaro, San Martín; Rafael, Pagani Mario

2014-01-01

Intellectual disability, commonly known as mental retardation in the International Classification of Disease from World Health Organization, is the term that describes an intellectual and adaptive cognitive disability that begins in early life during the developmental period. Currently the term intellectual disability is the preferred one. Although our understanding of the physiological basis of learning and learning disability is poor, a general idea is that such condition is quite permanent...

On the Origin of Multidecadal to Centennial Greenland Temperature Anomalies Over the Past 800 yr

Science.gov (United States)

Kobashi, T.; Shindell, D. T.; Kodera, K.; Box, J. E.; Nakaegawa, T.; Kawamura, K.

2013-01-01

The surface temperature of the Greenland ice sheet is among the most important climate variables for assessing how climate change may impact human societies due to its association with sea level rise. However, the causes of multidecadal-to-centennial temperature changes in Greenland temperatures are not well understood, largely owing to short observational records. To examine these, we calculated the Greenland temperature anomalies (GTA[G-NH]) over the past 800 yr by subtracting the standardized northern hemispheric (NH) temperature from the standardized Greenland temperature. This decomposes the Greenland temperature variation into background climate (NH); polar amplification; and regional variability (GTA[G-NH]). The central Greenland polar amplification factor as expressed by the variance ratio Greenland/NH is 2.6 over the past 161 yr, and 3.3-4.2 over the past 800 yr. The GTA[G-NH] explains 31-35%of the variation of Greenland temperature in the multidecadal-to-centennial time scale over the past 800 yr. We found that the GTA[G-NH] has been influenced by solar-induced changes in atmospheric circulation patterns such as those produced by the North Atlantic Oscillation/Arctic Oscillation (NAO/AO). Climate modeling and proxy temperature records indicate that the anomaly is also likely linked to solar-paced changes in the Atlantic meridional overturning circulation (AMOC) and associated changes in northward oceanic heat transport.

Feasibility/treatability studies for removal of heavy metals from training range soils at the Grafenwoehr Training Area, Germany

Energy Technology Data Exchange (ETDEWEB)

Peters, R.W.

1995-05-01

A feasibility/treatability study was performed to investigate the leaching potential of heavy metals (particularly lead) from soils at the Grafenw6hr Training Area (GTA) in Germany. The study included an evaluation of the effectiveness of chelant extraction to remediate the heavy-metal-contarninated soils. Batch shaker tests indicated that ethylenediaminetetraacetic acid (EDTA) (0.01M) was more effective than citric acid (0.01M) at removing cadmium, copper, lead, and zinc. EDTA and citric acid were equally effective in mobilizing chromium and barium from the soil. The batch shaker technique with chelant extraction offers promise as a remediation technique for heavy-metal-contaninated soil at the GTA. Columnar flooding tests conducted as part of the study revealed that deionized water was the least effective leaching solution for mobilization of the heavy metals; the maximum solubilization obtained was 3.72% for cadmium. EDTA (0.05M) achieved the greatest removal of lead (average removal of 17.6%). The difficulty of extraction using deionized water indicates that all of the heavy metals are very tightly bound to the soil; therefore, they are very stable in the GTA soils and do not pose a serious threat to the groundwater system. Columnar flooding probably does not represent a viable remediation technique for in-situ cleanup of heavy-metal-contaminated soils at the GTA.

Vent System Analysis for the Cryogenic Propellant Storage Transfer Ground Test Article

Science.gov (United States)

Hedayat, A

2013-01-01

To test and validate key capabilities and technologies required for future exploration elements such as large cryogenic propulsion stages and propellant depots, NASA is leading the efforts to develop and design the Cryogenic Propellant Storage and Transfer (CPST) Cryogenic Fluid Management (CFM) payload. The primary objectives of CPST payload are to demonstrate: 1) in-space storage of cryogenic propellants for long duration applications; and 2) in-space transfer of cryogenic propellants. The Ground Test Article (GTA) is a technology development version of the CPST payload. The GTA consists of flight-sized and flight-like storage and transfer tanks, liquid acquisition devices, transfer, and pressurization systems with all of the CPST functionality. The GTA is designed to perform integrated passive and active thermal storage and transfer performance testing with liquid hydrogen (LH2) in a vacuum environment. The GTA storage tank is designed to store liquid hydrogen and the transfer tank is designed to be 5% of the storage tank volume. The LH2 transfer subsystem is designed to transfer propellant from one tank to the other utilizing pressure or a pump. The LH2 vent subsystem is designed to prevent over-pressurization of the storage and transfer tanks. An in-house general-purpose computer program was utilized to model and simulate the vent subsystem operation. The modeling, analysis, and the results will be presented in the final paper.

On the origin of multidecadal to centennial Greenland temperature anomalies over the past 800 yr

Directory of Open Access Journals (Sweden)

T. Kobashi

2013-03-01

Full Text Available The surface temperature of the Greenland ice sheet is among the most important climate variables for assessing how climate change may impact human societies due to its association with sea level rise. However, the causes of multidecadal-to-centennial temperature changes in Greenland temperatures are not well understood, largely owing to short observational records. To examine these, we calculated the Greenland temperature anomalies (GTA[G-NH] over the past 800 yr by subtracting the standardized northern hemispheric (NH temperature from the standardized Greenland temperature. This decomposes the Greenland temperature variation into background climate (NH; polar amplification; and regional variability (GTA[G-NH]. The central Greenland polar amplification factor as expressed by the variance ratio Greenland/NH is 2.6 over the past 161 yr, and 3.3–4.2 over the past 800 yr. The GTA[G-NH] explains 31–35% of the variation of Greenland temperature in the multidecadal-to-centennial time scale over the past 800 yr. We found that the GTA[G-NH] has been influenced by solar-induced changes in atmospheric circulation patterns such as those produced by the North Atlantic Oscillation/Arctic Oscillation (NAO/AO. Climate modeling and proxy temperature records indicate that the anomaly is also likely linked to solar-paced changes in the Atlantic meridional overturning circulation (AMOC and associated changes in northward oceanic heat transport.

Fracture toughness of austenitic stainless steel weld metal at 4 K

International Nuclear Information System (INIS)

Goodwin, G.M.

1984-08-01

Selection of the welding processess and weld filler metals for fabrication of a large toroidal superconducting magnet is described. Data available in the literature are collected and compared with data generated in this study for three welding processes, shielded metal arc (SMA), gas tungsten arc (GTA), and flux cored arc (FCA) welds had the highest fracture toughness as measured by K/sub Ic/ estimated from J/sub Ic/. The SMA and FCA welds had about the same toughness, below the GTA values but above the average from the literature. The fracture mode for all three processes was typified by ductile dimples. The fracture morphology of the FCA weld specimens was influenced by the solidification substructure, and small particles were found to be nucleation sites for void formation, especially for the GTA welds. All three welding processes were deemed adequate for the intended service and were used to fabricate the large magnet. A trunnion-type turning fixture eliminated the need for welding in the vertical and overhead positions. The GTA process was used for all root passes, and the horizontal welds were filled by the SMA process. Over 80% of the welds were done in the flat position with the FCA process, and its high deposition rate and ease of operation are credited with contributing greatly to the success of the effort

Review Essay: Understanding in Professional Interactions

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Rainer Schützeichel

2012-07-01

Full Text Available "Professions" are work collaborations in which representatives of certain vocations address the life problems of "laypersons." In such relationships, adequate communication between representatives of the profession and laypersons is crucial in addressing their individual problems. Accordingly, "understanding," as well as interactional documentation of this understanding, is of considerable importance. The authors of the present volume, "Understanding in Professional Spheres of Activity,"  address the documentation of this understanding in certain professional spheres. They examine the requirements for the documentation of such understanding and the forms of documentation used in the fields of doctor-patient communication, counseling communication, and organizational collaboration on a movie set. Conversation analytic as well as ethnographically complemented studies draw further attention to an examination of the interactional level in its socio-structural context, and to that end the study employs a combination of conversational linguistics and sociological research. This contribution is therefore important not only in terms of linguistics but also sociologically. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1203142

Humor and creative life styles.

Science.gov (United States)

Richman, J

2001-01-01

This paper is based upon the writings of William James in the late 19th century, and Alfred Adler and Sigmund Freud in the 20th, enriched by the contributions of later personality and role theorists. The self is defined as the unique organization of each person; a style is the self in action. Different life styles and their components are expressed in different situations. I posit that humor and positive thinking, combined with meaning and purpose, are vital components of all constructive life styles. The knowledge of life styles cuts through diagnostic labels to reveal our universal humanity. It can be fruitfully applied to patients and nonpatients alike and, I found, for the self-understanding of therapist. The clinical application of life styles is illustrated through numerous vignettes.

Stories about life narrated by people with Alzheimer's disease.

Science.gov (United States)

Karlsson, Eva; Sävenstedt, Stefan; Axelsson, Karin; Zingmark, Karin

2014-12-01

To explore how people with Alzheimer's disease present their life story. Life story work is a key concept in a person-centred care. An important aspect in understanding the subjective experience and supporting the identity of people with dementia is to listen to their life stories. A narrative design with interviews was used. Nine participants with Alzheimer's disease were encouraged to tell about their lives from childhood, adult life, to present life and about their thoughts on the future. The interviews were conducted between September 2010-March 2011 in the participants' homes, with their spouses present and were analysed with a method for analysis of narratives. Contentment, Connectedness, Self-reliance and Personal growth were identified as core dimensions in the participants' life stories and shown like threads throughout life, from childhood, adult life to present life. All participants expressed an overall contentment with life, and connectedness was related to their relation with significant persons and to be included in the local community. Self-reliance was expressed as a strong confidence in the own ability and an overall curiosity throughout life as a sustained quest for personal growth. It is important for healthcare professionals, who work with people with dementia, to understand that people with Alzheimer's disease can maintain an overall trusting and hopeful approach to life. It is also important to use life story work to enhance feelings of being connected to the world and thereby support their identity and sense of self. © 2014 John Wiley & Sons Ltd.

The Tsimane Health and Life History Project: Integrating anthropology and biomedicine.

Science.gov (United States)

Gurven, Michael; Stieglitz, Jonathan; Trumble, Benjamin; Blackwell, Aaron D; Beheim, Bret; Davis, Helen; Hooper, Paul; Kaplan, Hillard

2017-04-01

The Tsimane Health and Life History Project, an integrated bio-behavioral study of the human life course, is designed to test competing hypotheses of human life-history evolution. One aim is to understand the bidirectional connections between life history and social behavior in a high-fertility, kin-based context lacking amenities of modern urban life (e.g. sanitation, banks, electricity). Another aim is to understand how a high pathogen burden influences health and well-being during development and adulthood. A third aim addresses how modernization shapes human life histories and sociality. Here we outline the project's goals, history, and main findings since its inception in 2002. We reflect on the implications of current findings and highlight the need for more coordinated ethnographic and biomedical study of contemporary nonindustrial populations to address broad questions that can situate evolutionary anthropology in a key position within the social and life sciences. © 2017 The Authors Evolutionary Anthropology: Issues, News, and Reviews Published by Wiley Periodicals, Inc.

The right to life

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Dr.Sc. Stavri Sinjari

2013-06-01

Full Text Available The right to life constitutes one of the main human rights and freedoms, foreseen by article 21 of the Albanian Constitution and article 2 of European Human Rights Convention. No democratic or totalitarian society can function without guarantees and protection of the human right to life We intend to address these issues on our article: What is life. What we legally understand with life. When the life starts and finish. How this right has evolved. Which is the state interest on protecting the life. Should we consider that the life is the same for all. Should the state interfere at any cost to protect the life. Is there any criminal charge for responsible persons to the violation of this right. Is this issue treated by European Human Rights Court. What are the Albanian legal provisions on protection of this right. This research is performed mainly according to a comparative and analytical methodology. Comperative analysis will be present almost throughout the paper. Treatment of issues of this research will be achieved through a system comparable with international standards in particular and the most advanced legislation in this area. At the same time, this research is conducted by analytical and statistical data processing. We believe that our research will make a modest contribution, not only to the legal literature, but also to criminal policy makers, law makers, lawyers and attorneys.

(Updated) Nanotechnology: Understanding the Tiny Particles That May Save a Life | Poster

Science.gov (United States)

By Nathalie Walker, Guest Writer Could nanotechnology—the study of tiny matter ranging in size from 1 to 200 nanometers—be the future of cancer treatment? Although it is a relatively new field in cancer research, nanotechnology is not new to everyday life. Have you ever thought about the tennis ball you’ve thrown with your dog at the park and wondered what it is made of?

Qualitative Inquiry in Everyday Life

DEFF Research Database (Denmark)

Brinkmann, Svend

This book is a 'survival guide' for students and researchers who would like to conduct a qualitative study with limited resources. Brinkmann shows how everyday life materials such as books, television, the internet, the media and everyday conversations and interactions can help us to understand...... larger social issues. As living human beings in cultural worlds, we are constantly surrounded by 'data' that call for analysis, and as we cope with the different situations and episodes of our lives, we are engaged in understanding and interpreting the world as a form of qualitative inquiry. The book...... helps its reader develop a disciplined and analytic awareness informed by theory, and shows how less can be more in qualitative research. Each chapter introduces theoretical tools to think with, and demonstrates how they can be put to use in working concretely with everyday life materials....

One life

Directory of Open Access Journals (Sweden)

Demkova E.E.

2016-06-01

Full Text Available It is not easy to care for a special needs child. Especially, it is easy to understand parents’ worries about their grown up children. Living in one’s own family or supported living in the community are much more preferable than the options the state can offer. The author — a mother of a young woman with autism — contemplates about possibilities for independent living for a person with special needs after their parents are gone. She is confident that teaching a child skills for independent living is not less important than giving them school education. The author illustrates her thoughts with real examples of support for adults with disabilities in their independent life or life in a foster family in a city, as well in rural areas.

Oxidative stress and life histories: unresolved issues and current needs.

Science.gov (United States)

Speakman, John R; Blount, Jonathan D; Bronikowski, Anne M; Buffenstein, Rochelle; Isaksson, Caroline; Kirkwood, Tom B L; Monaghan, Pat; Ozanne, Susan E; Beaulieu, Michaël; Briga, Michael; Carr, Sarah K; Christensen, Louise L; Cochemé, Helena M; Cram, Dominic L; Dantzer, Ben; Harper, Jim M; Jurk, Diana; King, Annette; Noguera, Jose C; Salin, Karine; Sild, Elin; Simons, Mirre J P; Smith, Shona; Stier, Antoine; Tobler, Michael; Vitikainen, Emma; Peaker, Malcolm; Selman, Colin

2015-12-01

Life-history theory concerns the trade-offs that mold the patterns of investment by animals between reproduction, growth, and survival. It is widely recognized that physiology plays a role in the mediation of life-history trade-offs, but the details remain obscure. As life-history theory concerns aspects of investment in the soma that influence survival, understanding the physiological basis of life histories is related, but not identical, to understanding the process of aging. One idea from the field of aging that has gained considerable traction in the area of life histories is that life-history trade-offs may be mediated by free radical production and oxidative stress. We outline here developments in this field and summarize a number of important unresolved issues that may guide future research efforts. The issues are as follows. First, different tissues and macromolecular targets of oxidative stress respond differently during reproduction. The functional significance of these changes, however, remains uncertain. Consequently there is a need for studies that link oxidative stress measurements to functional outcomes, such as survival. Second, measurements of oxidative stress are often highly invasive or terminal. Terminal studies of oxidative stress in wild animals, where detailed life-history information is available, cannot generally be performed without compromising the aims of the studies that generated the life-history data. There is a need therefore for novel non-invasive measurements of multi-tissue oxidative stress. Third, laboratory studies provide unrivaled opportunities for experimental manipulation but may fail to expose the physiology underpinning life-history effects, because of the benign laboratory environment. Fourth, the idea that oxidative stress might underlie life-history trade-offs does not make specific enough predictions that are amenable to testing. Moreover, there is a paucity of good alternative theoretical models on which contrasting

Pediatrician Ambiguity in Understanding Palliative Sedation at the End of Life.

Science.gov (United States)

Henderson, Carrie M; FitzGerald, Michael; Hoehn, K Sarah; Weidner, Norbert

2017-02-01

Palliative sedation is a means of relieving intractable symptoms at the end of life, however, guidelines about its use lack consistency. In addition, ethical concerns persist around the practice. There are reports of palliative sedation in the pediatric literature, which highlight various institutional perspectives. This survey of 4786 pediatric providers sought to describe their knowledge of and current practices around pediatric palliative sedation. Our survey was administered to pediatricians who care for children at the end of life. The survey assessed agreement with a definition of palliative sedation, as well as thoughts about its alignment with aggressive symptom management. Bivariate analyses using χ 2 and analysis of variance were calculated to determine the relationship between responses to closed-ended questions. Open-ended responses were thematically coded by the investigators and reviewed for agreement. Nearly half (48.6%) of the respondents indicated that the stated definition of palliative sedation "completely" reflected their own views. Respondents were split when asked if they viewed any difference between palliative sedation and aggressive symptom management: Yes (46%) versus No (54%). Open-ended responses revealed specifics about the nature of variation in interpretation. Responses point to ambiguity surrounding the concept of palliative sedation. Pediatricians were concerned with a decreased level of consciousness as the goal of palliative sedation. Respondents were split on whether they view palliative sedation as a distinct entity or as one broad continuum of care, equivalent to aggressive symptom management. Institutional-based policies are essential to clarify acceptable practice, enable open communication, and promote further research.

Implementing Life Cycle Assessment in systems development

DEFF Research Database (Denmark)

Bhander, Gurbakhash Singh; Hauschild, Michael Zwicky; McAloone, Timothy Charles

2003-01-01

and the rapid changes in markets for many products. The overall aim of the paper is to provide an understanding of the environmental issues involved in the early stages of product development and the capacity of life cycle assessment techniques to address these issues. The paper aims to outline the problems...... for the designer in evaluating the environmental benignity of the product from the outset and to provide the designer with a framework for decision support based on the performance evaluation at different stages of the design process. The overall aim of this paper is to produce an in-depth understanding...... of possibilities which can be introduced in the design stage compared to the other life cycle stages of the product system. The paper collects experiences and ideas around the state-of-the-art in eco-design, from literature and personal experience and further provides eco-design life cycle assessment strategies...

Health-Related Quality of Life (HRQOL Measures: There are Still Many Unanswered Questions about Human Life

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Mayowa Ojo Owolabi

2008-01-01

Full Text Available Health-related quality of life (HRQOL measures are used to assess the multifaceted impact of disease, and determine the utility and associated disability. In addition, the impact of medical interventions must be assessed by psychometrically robust HRQOL measures based on a comprehensive and dynamic model. To develop such a model, the concepts of life, its quality, domains, essence, and purpose must be properly and clearly understood. The correct understanding of these entities is specifically important for patient-centered medicine and has universal implications for all fields of human endeavor. Therefore, in order to explore questions about life and quality of life adequately, every necessary field of knowledge should be employed. A multilinguistic and etymological appraisal reveals that life is related to medicine, freedom, being, soul, and spirit, all of which must therefore be considered in its conceptualization.

The importance of understanding during the teaching process

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Dubljanin Saša

2015-01-01

Full Text Available Learning in the teaching process often goes on without proper understanding which is one of important problems that modern didactics tries to solve. In order to direct the totality of teaching towards understanding it is necessary to answer the question what understanding is, which is why we analysed different philosophical views on the concept of understanding and stressed their semblance to pedagogic explanations. Different kinds of understanding were analyzed as well as their role and contribution in different teaching situations, especially in the context of problem solving. As an alternative to the teaching based on accumulation of knowledge the characteristics and some principles of teaching focused on understanding are described, and the need for stimulating and developing understanding as an important goal of education. The results of our research unequivocally show that learning with understanding enables students to memorize the teaching material better, as well as to understand the whole teaching subject and efficiently apply the acquired knowledge out of school, and leads to more flexible behaviour and better coping in everyday life.

Life-oriented approach for urban policy decision-making: Surveys and applications

OpenAIRE

Junyi Zhang; Yubing Xiong; Minh Tu Tran

2014-01-01

In this study, we propose an additional approach, called life-oriented approach, for supporting urban policy decisions. The life-oriented approach argues that people's decisions on various life choices are not independent of each other and that an understanding of life choices should not be constrained by the boundary of any single discipline. People's life choices are closely linked with the quality of life (QOL), which can be roughly captured from the perspective of life domains such as res...

Work-life balance

Energy Technology Data Exchange (ETDEWEB)

Roche, Pat

2011-03-15

Gay Renouf has opted for a work/life balance; with a chemistry degree she joined the Saskatchewan Research Council out of graduate school in 1986. She first worked on understanding surfactants in emulsions and then dealt more with petroleum engineering issues like pipeline specifications. She is looking at waterfloods in heavy and medium gravity pools and has discovered factors helping to produce heavy oil waterfloods. But all Renouf's life is not devoted to her work: she has been working part-time, spending her free time being a parent, training for marathons and being a running coach. Renouf believes that her passion for running is consistent with her work as a scientist.

Abortion: Defending Life

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Myriam Aldana

2008-05-01

Full Text Available This essay will analyze some of the debates around abortion in the National Congress due to the Constitutional Amendment Bill – PEC25/95, by Deputy Severino Cavalcanti (PPB/PE, where the main issue was precisely life defense. The discursive blocks that present the debate in relation to pregnancy interruption, the religious principles or biological determinism on which those debates are based, and the ways in which such discourses are maintained will be identified. Distinct understandings of life, as a result of the points used in such discourses, which are aligned with the position of the Catholic Church and the Feminist Movement - the social actors of this debate- are also discussed here.

Graphics and control of the guide tube assembly reinforcement manipulators at Sizewell 'A'

International Nuclear Information System (INIS)

Burden, C.

1996-01-01

A method was devised to reinforce the lower lug welds of the Guide Tube Assemblies (GTA's) at Sizewell 'A'. A six degree of freedom manipulator was designed to place a clamp around the lugs and tighten it. The manipulator was fitted with the three fixed cameras but required another surveillance manipulator positioned in an adjacent standpipe to provide additional views. The need to prepare two standpipes limited the rate at which reinforcements could be made. Therefore an articulated two arm camera manipulator, which could be used on the existing manipulator mast was designed and built. The two manipulators were driven from separate desks and were controlled by the same supervisory computer linked to online graphics. The camera arm joints were driven on preplanned routes using a single joystick because of the complex moves and tight spaces involved. A large number of GTA sites have now been reinforced including a dropped GTA which had to be raised to carry out clamping. (Author)

In vitro assembly of a prohead-like structure of the Rhodobacter capsulatus gene transfer agent

International Nuclear Information System (INIS)

Spano, Anthony J.; Chen, Frank S.; Goodman, Benjamin E.; Sabat, Agnes E.; Simon, Martha N.; Wall, Joseph S.; Correia, John J.; McIvor, Wilson; Newcomb, William W.; Brown, Jay C.; Schnur, Joel M.; Lebedev, Nikolai

2007-01-01

The gene transfer agent (GTA) is a phage-like particle capable of exchanging double-stranded DNA fragments between cells of the photosynthetic bacterium Rhodobacter capsulatus. Here we show that the major capsid protein of GTA, expressed in E. coli, can be assembled into prohead-like structures in the presence of calcium ions in vitro. Transmission electron microscopy (TEM) of uranyl acetate staining material and thin sections of glutaraldehyde-fixed material demonstrates that these associates have spherical structures with diameters in the range of 27-35 nm. The analysis of scanning TEM images revealed particles of mass ∼ 4.3 MDa, representing 101 ± 11 copies of the monomeric subunit. The establishment of this simple and rapid method to form prohead-like particles permits the GTA system to be used for genome manipulation within the photosynthetic bacterium, for specific targeted drug delivery, and for the construction of biologically based distributed autonomous sensors for environmental monitoring

UNDERSTANDING THE PUERTO RICAN AND HIS FAMILY.

Science.gov (United States)

THOMAS MARIE, SISTER

AN UNDERSTANDING OF TRADITIONAL PUERTO RICAN FAMILY CUSTOMS AND BASIC DIFFERENCES BETWEEN PUERTO RICAN AND OTHER LIFE STYLES SHOULD HELP PROFESSIONAL WORKERS SOLVE THE PROBLEMS CREATED BY MIGRATION TO THE UNITED STATES. THE CULTURE OF THE PUERTO RICAN CAN BE DESCRIBED IN RELATION TO THREE CONCEPTS--DIGNIDAD (SELF-ESTEEM OR SELF-WORTH), RESPETO…

A life course understanding of domestic and intimate partner violence in Ghana.

Science.gov (United States)

Tenkorang, Eric Y; Owusu, Adobea Y

2018-05-01

Previous studies demonstrate the long term effects of childhood violence on future victimization and perpetration of intimate partner violence (IPV). With a few exceptions from Asia, however, this literature is largely limited to North America and Europe. To date, contributions from sub-Saharan Africa remain scant. We began to fill this gap by applying the life course theory to retrospective data collected from 2289 women in Ghana. Specifically, we examined if women's childhood experiences of family violence were associated with their later victimization and/or their perpetration of IPV. We also explored the effect of the timing and continuity of family violence over the life course. Generally, we found that women with childhood experiences of violence were more likely to be victims and perpetrators of IPV than those with no such experiences. However, the effect and significance of the violence was more pronounced if it continued from early childhood (before age 15) to adulthood (after age 15). Violence experienced after age 15 was more significant than violence experienced before age 15, and women who perpetrated IPV were significantly more likely to be victimized themselves. To improve domestic violence interventions in Ghana, it is necessary to pay attention to victims' early childhood experiences. Copyright © 2018 Elsevier Ltd. All rights reserved.

Understanding future emissions from low-carbon power systems by integration of life-cycle assessment and integrated energy modelling

Science.gov (United States)

Pehl, Michaja; Arvesen, Anders; Humpenöder, Florian; Popp, Alexander; Hertwich, Edgar G.; Luderer, Gunnar

2017-12-01

Both fossil-fuel and non-fossil-fuel power technologies induce life-cycle greenhouse gas emissions, mainly due to their embodied energy requirements for construction and operation, and upstream CH4 emissions. Here, we integrate prospective life-cycle assessment with global integrated energy-economy-land-use-climate modelling to explore life-cycle emissions of future low-carbon power supply systems and implications for technology choice. Future per-unit life-cycle emissions differ substantially across technologies. For a climate protection scenario, we project life-cycle emissions from fossil fuel carbon capture and sequestration plants of 78-110 gCO2eq kWh-1, compared with 3.5-12 gCO2eq kWh-1 for nuclear, wind and solar power for 2050. Life-cycle emissions from hydropower and bioenergy are substantial (˜100 gCO2eq kWh-1), but highly uncertain. We find that cumulative emissions attributable to upscaling low-carbon power other than hydropower are small compared with direct sectoral fossil fuel emissions and the total carbon budget. Fully considering life-cycle greenhouse gas emissions has only modest effects on the scale and structure of power production in cost-optimal mitigation scenarios.

Astrobiology and the Possibility of Life on Earth and Elsewhere…

Science.gov (United States)

Cottin, Hervé; Kotler, Julia Michelle; Bartik, Kristin; Cleaves, H. James; Cockell, Charles S.; de Vera, Jean-Pierre P.; Ehrenfreund, Pascale; Leuko, Stefan; Ten Kate, Inge Loes; Martins, Zita; Pascal, Robert; Quinn, Richard; Rettberg, Petra; Westall, Frances

2017-07-01

Astrobiology is an interdisciplinary scientific field not only focused on the search of extraterrestrial life, but also on deciphering the key environmental parameters that have enabled the emergence of life on Earth. Understanding these physical and chemical parameters is fundamental knowledge necessary not only for discovering life or signs of life on other planets, but also for understanding our own terrestrial environment. Therefore, astrobiology pushes us to combine different perspectives such as the conditions on the primitive Earth, the physicochemical limits of life, exploration of habitable environments in the Solar System, and the search for signatures of life in exoplanets. Chemists, biologists, geologists, planetologists and astrophysicists are contributing extensively to this interdisciplinary research field. From 2011 to 2014, the European Space Agency (ESA) had the initiative to gather a Topical Team of interdisciplinary scientists focused on astrobiology to review the profound transformations in the field that have occurred since the beginning of the new century. The present paper is an interdisciplinary review of current research in astrobiology, covering the major advances and main outlooks in the field. The following subjects will be reviewed and most recent discoveries will be highlighted: the new understanding of planetary system formation including the specificity of the Earth among the diversity of planets, the origin of water on Earth and its unique combined properties among solvents for the emergence of life, the idea that the Earth could have been habitable during the Hadean Era, the inventory of endogenous and exogenous sources of organic matter and new concepts about how chemistry could evolve towards biological molecules and biological systems. In addition, many new findings show the remarkable potential life has for adaptation and survival in extreme environments. All those results from different fields of science are guiding our

Four Essays on Family Life Events

DEFF Research Database (Denmark)

Loft, Lisbeth Trille Gylling

. In addition, the present thesis underlines the need for an improved understanding of the role of health and caregiving as fundamental aspects of family life, and in doing so allocates increased attention to how children’s characteristics are central to family-level outcomes. Just as the lives of family......As demographic and social trends continue to change the institution of the family, a need to reconsider the study family life events as they unfold over the life course has emerged. To advance current knowledge of social dynamics associated with this new complexity, the point of departure...... of the present thesis is the way in which individual, social, and institutional contexts shape family life events. The main objective of the present thesis is twofold: to highlight the importance of how family life events are theoretically understood and methodologically approached, and to examine why social...

Interrogating Biosensing in Everyday Life

DEFF Research Database (Denmark)

Merrill, Nick; Wong, Richmond; Howell, Noura

2017-01-01

This workshop seeks to expand our understanding and imaginations regarding the possible roles biosensors (sensors measuring humans) can-and should-play in everyday life. By applying a critical lens to issues of interpretation, representation, and experience around biosensing and biosensors, we ai...

'Just give me the best quality of life questionnaire': the Karnofsky scale and the history of quality of life measurements in cancer trials.

Science.gov (United States)

Timmermann, Carsten

2013-09-01

To use the history of the Karnofsky Performance Scale as a case study illustrating the emergence of interest in the measurement and standardisation of quality of life; to understand the origins of current-day practices. Articles referring to the Karnofsky scale and quality of life measurements published from the 1940s to the 1990s were identified by searching databases and screening journals, and analysed using close-reading techniques. Secondary literature was consulted to understand the context in which articles were written. The Karnofsky scale was devised for a different purpose than measuring quality of life: as a standardisation device that helped quantify effects of chemotherapeutic agents less easily measurable than survival time. Interest in measuring quality of life only emerged around 1970. When quality of life measurements were increasingly widely discussed in the medical press from the late 1970s onwards, a consensus emerged that the Karnofsky scale was not a very good tool. More sophisticated approaches were developed, but Karnofsky continued to be used. I argue that the scale provided a quick and simple, approximate assessment of the 'soft' effects of treatment by physicians, overlapping but not identical with quality of life.

High profile students’ growth of mathematical understanding in solving linier programing problems

Science.gov (United States)

Utomo; Kusmayadi, TA; Pramudya, I.

2018-04-01

Linear program has an important role in human’s life. This linear program is learned in senior high school and college levels. This material is applied in economy, transportation, military and others. Therefore, mastering linear program is useful for provision of life. This research describes a growth of mathematical understanding in solving linear programming problems based on the growth of understanding by the Piere-Kieren model. Thus, this research used qualitative approach. The subjects were students of grade XI in Salatiga city. The subjects of this study were two students who had high profiles. The researcher generally chose the subjects based on the growth of understanding from a test result in the classroom; the mark from the prerequisite material was ≥ 75. Both of the subjects were interviewed by the researcher to know the students’ growth of mathematical understanding in solving linear programming problems. The finding of this research showed that the subjects often folding back to the primitive knowing level to go forward to the next level. It happened because the subjects’ primitive understanding was not comprehensive.

Extraterrestrial Life in the Microbial Age

Science.gov (United States)

Gronstal, Aaron L.

Humankind has long been fascinated with the potential for alien civilizations within the Solar System and beyond (e.g., Crowe and Dowd 2013; Sullivan 2013). Despite the early optimism for life beyond Earth, humankind has yet to make first contact with an alien race. Historical discourse on the topic of alien life can provide some useful input into questions about how the people of Earth today might respond to contact with alien life (e.g., Dick 2013). However, this discourse is primarily devoted to understanding humankind's response to intelligent life. We must recognize that the search for life's potential beyond Earth has dramatically changed since the dawn of the Space Age. We now know that advanced civilizations are not common on planets in our solar system. The search for life on nearby worlds is now limited to non-intelligent, microbial life. Any chance we have of contacting intelligent life lies in receiving transmissions from distant worlds, and contact with such cultures would be greatly limited by the vast expanse of space. This chapter discusses the need for more attention paid to the possible social, economic, and legal ramifications that the discovery of non-intelligent, alien microbial life might bring.

Contextualizing the self: the emergence of a biographical understanding in adolescence.

Science.gov (United States)

Habermas, Tilmann; Hatiboğlu, Neşe

2014-01-01

In adolescence, remembering the personal past and understanding what kind of person one is intertwine to form a story of one's life as the most extant, informative, and flexible form of self-representation. In adolescence, the striving for self-coherence translates into a quest for global coherence of the life story. We suggest that contextualizing is a fifth means for creating global coherence in life narratives besides the cultural concept of biography, temporal, causal-motivational, and thematic coherence. We present three kinds of contextualizing in life narratives, the temporal macrostructure, sociohistorical contextualizing of one's life, and hierarchical and linear segmenting of the text and life. These three forms of contextualizing in life narratives by their authors are complemented by three forms of contextual influences on life narratives analyzed by researchers, namely the historical, personal, and communicative situation in which they are recounted. Contextualizing is exemplified by the life narrative of a young migrant. © 2014 Wiley Periodicals, Inc.

Design Enriches Life，Life Breeds Fashion

Directory of Open Access Journals (Sweden)

Yun Gong

2016-11-01

Full Text Available As society advances and technology changes,fashion design has developed from the initial few exclusive to public demand, and fashion category also covers all walks of life, extends to every area from a single demand to industrialization. Fashion design development, has become an indispensable part of people's lives. Fashion satisfies public demand, reflecting the public interest towards, and designer correctly grasp of fashion and taste of popular motivated the design of continuous innovation to creating new business value, cultural values of the social value of fashion. A precise definition to fashion is hard, cause too broad as it relates to areas, such as products, clothing, entertainment, advertising, decoration, home, fashion is reach into every aspect of our lives. Fashion derived from life elements, convergence elements of era and innovation into your life all over again, this cycle forward and updated, fully embodies the understanding of art and life. Design enriches life, life gave birth to fashion.

Work and personal life boundary management: boundary strength, work/personal life balance, and the segmentation-integration continuum.

Science.gov (United States)

Bulger, Carrie A; Matthews, Russell A; Hoffman, Mark E

2007-10-01

While researchers are increasingly interested in understanding the boundaries surrounding the work and personal life domains, few have tested the propositions set forth by theory. Boundary theory proposes that individuals manage the boundaries between work and personal life through processes of segmenting and/or integrating the domains. The authors investigated boundary management profiles of 332 workers in an investigation of the segmentation-integration continuum. Cluster analysis indicated consistent clusters of boundary management practices related to varying segmentation and integration of the work and personal life domains. But, the authors suggest that the segmentation-integration continuum may be more complicated. Results also indicated relationships between boundary management practices and work-personal life interference and work-personal life enhancement. Less flexible and more permeable boundaries were related to more interference, while more flexible and more permeable boundaries were related to more enhancement.

Parents' traces in life: When and how parents are presented in spontaneous life narratives.

Science.gov (United States)

Köber, Christin; Habermas, Tilmann

2017-08-26

Although parents are acknowledged to be a part of their children's personality and narrative identity and to remain important across the life span, narrative personality research has not yet explored the spontaneous presentation of parents in life stories. Therefore, this study examined longitudinally the place given to parents when crafting one's life narrative and how this changes with age. Furthermore, in contrast to prior studies, we focused on spontaneous mentions of parents. We investigated how often parents are mentioned in life narratives of six age groups spanning from age 8 to 69, how the parental relationship is evaluated, whether narrators express understanding of their parents, and whether they respond to parental values. People of all ages dedicated a substantial part of their life narratives to their parents and evaluated their relationship with them in an increasingly differentiated manner. Parents were increasingly perceived as individuals beyond their parental nurturing role. Until late in life, individuals reflect on values and opinions that were transferred to them by their parents. Parents hold a consistent place in life narratives, emphasizing their importance for narrative identity. Results are discussed in terms of lifelong child-parent relationships. Directions for future research are outlined. © 2017 Wiley Periodicals, Inc.

Spiritual life in the understanding of the younger generation of the 21st century

Directory of Open Access Journals (Sweden)

Sapunkova Vera Igorevna

2014-07-01

Full Text Available The article considers the concept of "spiritual life" from a secular point of view, the analysis of the educational environment that should form the spiritually developed modern generation.

Life Work Balance in the Context of the Navy

OpenAIRE

Aten, Kathryn; DiRenzo, Marco; Eitelberg, Mark; Smith, Michael; Emanuelsen, Kirk; Lee, Jon

2015-01-01

The objective of this study is to compare male and female Sailors' understandings, definitions and desires regarding life-work balance and recommend policies and practices to support the balance of work and life roles in the context of Naval careers in order to improve the retention of female Sailors, in particular. In short, this study will explore, "How do Sailors define life-work balance in the context of their Naval careers?" and “What policies and practices are likely to support life- wo...

Turn to Practice Within Working Life Studies

DEFF Research Database (Denmark)

Buch, Anders; Andersen, Vibeke; Klemsdal, Lars

2015-01-01

practice theoretical approaches can help working life studies in better understanding work practices and the material, technological, economic, organizational, and societal conditions that shape and are shaped by these practices. In addition, this issue contains three reviews of recent practice theoretical......What does practice theory and practice-based studies have to offer working life studies? This is the seminal question this special issue poses. In seven articles, researchers with an affiliation to Nordic working life studies and with a background in practice theory illustrate and reflect on how...

LIFE: Life Investigation For Enceladus A Sample Return Mission Concept in Search for Evidence of Life.

Science.gov (United States)

Tsou, Peter; Brownlee, Donald E; McKay, Christopher P; Anbar, Ariel D; Yano, Hajime; Altwegg, Kathrin; Beegle, Luther W; Dissly, Richard; Strange, Nathan J; Kanik, Isik

2012-08-01

Life Investigation For Enceladus (LIFE) presents a low-cost sample return mission to Enceladus, a body with high astrobiological potential. There is ample evidence that liquid water exists under ice coverage in the form of active geysers in the "tiger stripes" area of the southern Enceladus hemisphere. This active plume consists of gas and ice particles and enables the sampling of fresh materials from the interior that may originate from a liquid water source. The particles consist mostly of water ice and are 1-10 μ in diameter. The plume composition shows H(2)O, CO(2), CH(4), NH(3), Ar, and evidence that more complex organic species might be present. Since life on Earth exists whenever liquid water, organics, and energy coexist, understanding the chemical components of the emanating ice particles could indicate whether life is potentially present on Enceladus. The icy worlds of the outer planets are testing grounds for some of the theories for the origin of life on Earth. The LIFE mission concept is envisioned in two parts: first, to orbit Saturn (in order to achieve lower sampling speeds, approaching 2 km/s, and thus enable a softer sample collection impact than Stardust, and to make possible multiple flybys of Enceladus); second, to sample Enceladus' plume, the E ring of Saturn, and the Titan upper atmosphere. With new findings from these samples, NASA could provide detailed chemical and isotopic and, potentially, biological compositional context of the plume. Since the duration of the Enceladus plume is unpredictable, it is imperative that these samples are captured at the earliest flight opportunity. If LIFE is launched before 2019, it could take advantage of a Jupiter gravity assist, which would thus reduce mission lifetimes and launch vehicle costs. The LIFE concept offers science returns comparable to those of a Flagship mission but at the measurably lower sample return costs of a Discovery-class mission.

Towards a Universal Biology: Is the Origin and Evolution of Life Predictable?

Science.gov (United States)

Rothschild, Lynn J.

2017-01-01

The origin and evolution of life seems an unpredictable oddity, based on the quirks of contingency. Celebrated by the late Stephen Jay Gould in several books, "evolution by contingency" has all the adventure of a thriller, but lacks the predictive power of the physical sciences. Not necessarily so, replied Simon Conway Morris, for convergence reassures us that certain evolutionary responses are replicable. The outcome of this debate is critical to Astrobiology. How can we understand where we came from on Earth without prophesy? Further, we cannot design a rational strategy for the search for life elsewhere - or to understand what the future will hold for life on Earth and beyond - without extrapolating from pre-biotic chemistry and evolution. There are several indirect approaches to understanding, and thus describing, what life must be. These include philosophical approaches to defining life (is there even a satisfactory definition of life?), using what we know of physics, chemistry and life to imagine alternate scenarios, using different approaches that life takes as pseudoreplicates (e.g., ribosomal vs non-ribosomal protein synthesis), and experimental approaches to understand the art of the possible. Given that: (1) Life is a process based on physical components rather than simply an object; (2). Life is likely based on organic carbon and needs a solvent for chemistry, most likely water, and (3) Looking for convergence in terrestrial evolution we can predict certain tendencies, if not quite "laws", that provide predictive power. Biological history must obey the laws of physics and chemistry, the principles of natural selection, the constraints of an evolutionary past, genetics, and developmental biology. This amalgam creates a surprising amount of predictive power in the broad outline. Critical is the apparent prevalence of organic chemistry, and uniformity in the universe of the laws of chemistry and physics. Instructive is the widespread occurrence of

SIMPLE LIFE AND RELIGION

Directory of Open Access Journals (Sweden)

Ahmet YILDIRIM

2014-07-01

Full Text Available Individuals in terms of the economy in which we live is one of the most important phenomenon of the century. This phenomenon present itself as the only determinant of people's lives by entering almost makes itself felt. The mo st obvious objective needs of the economy by triggering motive is to induce people to consume . Consumer culture pervades all aspects of the situation are people . Therefore, these people have the blessing of culture , beauty and value all in the name of w hatever is consumed. This is way out of the siege of moral and religious values we have is to go back again . Referred by local cultural and religious values, based on today increasingly come to the fore and the Muslim way of life appears to be close to th e plain / lean preferred by many people life has been a way of life. Even the simple life , a way of life in the Western world , a conception of life , a philosophy, a movement as it has become widely accepted. Here in determining the Muslim way of life Pr ophet. Prophet (sa lived the kind of life a very important model, sample, and determining which direction is known. Religious values, which is the carrier of the prophets, sent to the society they have always been examples and models. Because every aspect of human life, his life style and the surrounding area has a feature. We also value his life that he has unknowingly and without learning and skills and to understand it is not possible to live our religion . We also our presentation, we mainly of Islam o utlook on life and predicted life - style, including the Prophet of Islam 's (sa simple life to scrutinize and lifestyle issues related to reveal , in short Islam's how life has embraced and the Prophet. Prophet's will try to find answers to questions reg arding how to live.

Career management: understanding the process.

Science.gov (United States)

Mackowiak, J; Eckel, F M

1985-02-01

This article is the first of a three-part series on career management for hospital pharmacists. Work attitudes, life cycles, needs, and career trends are discussed. Three basic work attitudes exist. Some see work as punishment. Others believe work in itself is good, i.e., they have a strong work ethic. Some view work as a means to satisfy, at least partially, a range of needs. Attitudinal transition points are likely to occur at specific times in the adult life cycle. The stages of the life cycle can be labeled as leaving, reaching out, questioning, midlife crisis, settling down, and mellowing. A progression through each of these stages is required for normal adult psychological development. Every individual exhibits a blend of needs that changes throughout life. Jobs can fulfill existence, relatedness, and growth needs. Relatedness needs include the need for love, affiliation, social esteem, and power, and growth needs include the need for self-esteem, competence, achievement, and autonomy. Three important career trends are the changing opportunities for advancement, women in careers, and dual-career couples. The number of women pharmacists is increasing as is the number of two-career couples. Tips for managing two-career relationships are presented. Pharmacists can manage their careers more effectively by understanding their needs, identifying their basic attitude toward work, and being aware of the trends occurring in pharmacy.

Universe in creation a new understanding of the Big Bang and the emergence of life

CERN Document Server

Gould, Roy G

2018-01-01

We know the universe has a history, but does it also have a story of self-creation to tell? Yes, in Roy R. Gould's account. He offers a compelling narrative of how the universe with no instruction other than its own laws evolved into billions of galaxies and gave rise to life, including humans who have been trying for millennia to comprehend it. Far from being a random accident, the universe is hard at work, extracting order from chaos. Making use of the best current science, Gould turns what many assume to be true about the universe on its head. The cosmos expands inward, not outward. Gravity can drive things apart, not merely together. And the universe seems to defy entropy as it becomes more ordered, rather than the other way around. Strangest of all, the universe is exquisitely hospitable to life, despite its being constructed from undistinguished atoms and a few unexceptional rules of behavior. Universe in Creation explores whether the emergence of life, rather than being a mere cosmic afterthought, may...

Biomaterials innovation bundling technologies and life

CERN Document Server

Styhre, A

2014-01-01

Rapid advances in the life sciences means that there is now a far more detailed understanding of biological systems on the cellular, molecular and genetic levels. Sited at the intersection between the life sciences, the engineering sciences and the design sciences, innovations in the biomaterials industry are expected to garner increasing attention and play a key role in future development. This book examines the biomaterials innovations taking place in corporations and in academic research settings today.

Life Course, Green Space and Health: Incorporating Place into Life Course Epidemiology

Directory of Open Access Journals (Sweden)

Jamie Pearce

2016-03-01

Full Text Available Researchers interested in the relationships between place and health have been slow to incorporate a life course perspective, probably due to the lack of readily available historical environmental data. This hinders the identification of causal relationships. It also restricts our understanding as to whether there are accumulative effects over the life course and if there are critical periods in people’s lives when places are particularly pertinent. This study considers the feasibility of constructing longitudinal data on the availability of urban green space. The suitability of various historical and contemporary data sources is considered, including paper maps, aerial photographs and tabular land use data. Measures of urban green space are created for all neighbourhoods across the Edinburgh region of Scotland at various points during the past 100 years. We demonstrate that it is feasible to develop such measures, but there are complex issues involved in doing so. We also test the utility of the measures via an analysis of how accessibility to green space might alter over the life course of both people, and their residential neighbourhoods. The findings emphasise the potential for utilising historical data to significantly enhance understanding of the relationships between nature and health, and between health and place more generally. We encourage researchers to use data from other locations to consider including a longitudinal perspective to examine relationships between people’s health and their environment.

The Past, Present, and Future of Artificial Life

Directory of Open Access Journals (Sweden)

Wendy eAguilar

2014-10-01

Full Text Available For millennia people have wondered what makes the living different from the non-living. Beginning in the mid-1980s, artificial life has studied living systems using a synthetic approach: build life in order to understand it better, be it by means of software, hardware, or wetware. This review provides a summary of the advances that led to the development of artificial life, its current research topics, and open problems and opportunities. We classify artificial life research into fourteen themes: origins of life, autonomy, self-organization, adaptation (including evolution, development, and learning, ecology, artificial societies, behavior, computational biology, artificial chemistries, information, living technology, art, and philosophy. Being interdisciplinary, artificial life seems to be losing its boundaries and merging with other fields.

Evaluating the SCC resistance of underwater welds in sodium tetrathionate

International Nuclear Information System (INIS)

White, R.A.; Angeliu, T.M.

1997-01-01

The susceptibility of welds to stress corrosion cracking (SCC) is enhanced by the surface residual tensile stresses generated by the typical welding process. However, underwater plasma transferred arc (PTA) welding has been shown to produce compressive surface residual stresses, an encouraging result if repairs of cracked boiling water reactor (BWR) components are to be made without further endangering them to SCC. This program was designed to verify that underwater PTA welds are resistant to SCC and to determine if underwater PTA welding could mitigate SCC in potentially susceptible welds. This was achieved by exposing various welds on solution annealed (SA) and SA + thermally sensitized 304 stainless steel at 25 C in a solution of 1.5 gm/liter of sodium sulfide added to 0.05M sodium tetrathionate, titrated to a pH of 1.25 with H 2 SO 4 . The autogeneous welds were produced using gas tungsten arc (GTA) and plasma transferred arc (PTA) welding under atmospheric conditions, and PTA welding underwater. After 1 hour of sodium tetrathionate exposure, GTA and air PTA welds exhibited SCC while the underwater PTA weld heat affected zones were more resistant. Underwater PTA welds bisecting a GTA weld eliminated the cracking in the GTA weld heat affected zone under certain conditions. The lack of IG cracking in the region influenced by the underwater PTA weld is consistent with the measurement of compressive surface residual stresses inherent to the underwater welding process

College Students' Life Experiences in Korea and in the U.S.

Science.gov (United States)

Kang, Sunwoo; Youn, Gahyun; Stilwell, William E.

2014-01-01

Even though college students may be faced with developmental life tasks that might lead them to cognitive and emotional growth, little is known about how college students' life experiences are related to their cultural values. Understanding college students' life across culture requires both exploratory and confirmatory approaches to examine (1)…

Insights on Adolescence from a Life Course Perspective

Science.gov (United States)

Johnson, Monica Kirkpatrick; Crosnoe, Robert; Elder, Glen H., Jr.

2011-01-01

In this essay, we argue that viewing adolescence within the full life course will improve our understanding of both adolescence itself and the life course more generally. Such an approach makes explicit how adolescence is linked to developmental processes in the years both before and after adolescence in ways that are shaped by broader patterns of…

A Life Course Approach to Understanding Poverty Among Older American Adults*

Science.gov (United States)

Rank, Mark R.; Hadley, Herbert S.; Williams, James Herbert

2014-01-01

A relatively new strategy for studying the prevalence of poverty in America is to analyze it as a potential life course event. We use such an approach in order to examine the likelihood of both income and asset poverty for individuals between the ages of 60 and 90. Nearly half of all elderly Americans will encounter at least one year of poverty or near poverty across these ages. In addition, 58 percent of those between the ages of 60 and 84 will at some point fail to have enough liquid assets to allow them to weather an unanticipated expense or downturn in income. The policy and practice implications of these findings are discussed. PMID:25104897

Astrobiology and the Possibility of Life on Earth and Elsewhere…

NARCIS (Netherlands)

Cottin, Hervé; Kotler, Julia Michelle; Bartik, Kristin; Cleaves, H. James; Cockell, Charles S.; de Vera, Jean Pierre P; Ehrenfreund, Pascale; Leuko, Stefan; Ten Kate, Inge Loes|info:eu-repo/dai/nl/292012217; Martins, Zita; Pascal, Robert; Quinn, Richard; Rettberg, Petra; Westall, Frances

Astrobiology is an interdisciplinary scientific field not only focused on the search of extraterrestrial life, but also on deciphering the key environmental parameters that have enabled the emergence of life on Earth. Understanding these physical and chemical parameters is fundamental knowledge

A Demonstration Marine Biodiversity Observation Network (MBON): Understanding Marine Life and its Role in Maintaining Ecosystem Services

Science.gov (United States)

Muller-Karger, F. E.; Iken, K.; Miller, R. J.; Duffy, J. E.; Chavez, F.; Montes, E.

2016-02-01

The U.S. Federal government (NOAA, NASA, BOEM, and the Smithsonian Institution), academic researchers, and private partners are laying the foundation for a Marine Biodiversity Observation Network (MBON). The goals of the network are to: 1) Observe and understand life, from microbes to whales, in different coastal and continental shelf habitats; 2) Define an efficient set of observations required for implementing a useful MBON; 3) Develop technology for biodiversity assessments including emerging environmental DNA (eDNA), remote sensing, and image analysis methods to coordinate with classical sampling; 4) Integrate and synthesize information in coordination with the Integrated Ocean Observing System (IOOS), the international Group on Earth Observations Biodiversity Observation Network(GEO BON), and the Ocean Biogeographic Information System (OBIS) sponsored by UNESCO's Intergovernmental Oceanographic Commission (IOC); and 5) Understand the linkages between marine biodiversity, ecosystem processes, and the social-economic context of a region. Pilot projects have been implemented within three NOAA National Marine Sanctuaries (Florida Keys, Monterey Bay, and Channel Islands), the wider Santa Barbara Channel, in the Chukchi Sea, and through the Smithsonian's Tennenbaum Marine Observatories Network (TMON) at several sites in the U.S. and collaborating countries. Together, these MBON sites encompass a wide range of marine environments, including deep sea, continental shelves, and coastal habitats including estuaries, wetlands, and coral reefs. The present MBON partners are open to growth of the MBON through additional collaborations. Given these initiatives, GEO BON is proposing an MBON effort that spans from pole to pole, with a pathfinder effort among countries in the Americas. By specializing in coastal ecosystems—where marine biodiversity and people are concentrated and interact most—the MBON and TMON initiatives aim to provide policymakers with the science to

MERCURY IN MARINE LIFE DATABASE

Science.gov (United States)

The purpose of the Mercury in Marine Life Project is to organize information on estuarine and marine species so that EPA can better understand both the extent of monitoring for mercury and level of mercury contamination in the biota of coastal environments. This report follows a ...

A life course perspective on polycystic ovary syndrome

Directory of Open Access Journals (Sweden)

Sanchez N

2014-01-01

Full Text Available Ninive SanchezSchool of Social Work, University of Michigan, Ann Arbor, MI, USAAbstract: Polycystic ovary syndrome (PCOS is a major public health problem in the US. Worldwide, the public is largely unaware of the condition and health care providers do not seem to fully understand it. Research on PCOS has primarily focused on its etiology and clinical characteristics and less on the psychosocial aspects of human development associated with PCOS. This paper posits that a life course perspective provides a framework for further understanding the psychosocial experiences of women with PCOS and the contexts in which they live. The paper discusses how life course principles of human development, constraints on agency, interdependence of lives, time and place, and timing of events and experiences are relevant to the management of PCOS and prevention of its complications.Keywords: polycystic ovary syndrome, psychosocial, mental health, multidisciplinary, life course, adolescence

Prediction of thermal fatigue life of ceramics

International Nuclear Information System (INIS)

Kamiya, N.; Kamigaito, O.

1979-01-01

On the assumption that the thermal fatigue life of ceramics is determined mainly by the duration over which a crack reaches a small critical length, a prediction of the life was made by application of fracture mechanics to ceramics based on subcritical crack growth. Approximated formulae were derived. Experimental examination showed that the formulae proved to be valid for glass, sintered mullite under moderate shock severity, and zirconia. Data given by other authors also prove their validity. The deviation of the life from the formulae for sintered mullite under a thermal shock of extremely low severty, suggests that a certain mechanism, for example strengthening, is needed to understand the life of the sintered mullite. (author)

Darlington steam generator life assurance program

International Nuclear Information System (INIS)

Jelinski, E.; Dymarski, M.; Maruska, C.; Cartar, E.

1995-01-01

The Darlington Nuclear Generating Station belonging to Ontario Hydro is one of the most modern and advanced nuclear generating stations in the world. Four reactor units each generate 881 net MW, enough to provide power to a major city, and representing approximately 20% of the Ontario grid. The nuclear generating capacity in Ontario represents approximately 60% of the grid. In order to look after this major asset, many proactive preventative and predictive maintenance programs are being put in place. The steam generators are a major component in any power plant. World wide experience shows that nuclear steam generators require specialized attention to ensure reliable operation over the station life. This paper describes the Darlington steam generator life assurance program in terms of degradation identification, monitoring and management. The requirements for chemistry control, surveillance of process parameters, surveillance of inspection parameters, and the integration of preventative and predictive maintenance programs such as water lancing, chemical cleaning, RIHT monitoring, and other diagnostics to enhance our understanding of life management issues are identified and discussed. We conclude that we have advanced proactive activities to avoid and to minimize many of the problems affecting other steam generators. An effective steam generator maintenance program must expand the knowledge horizon to understand life limiting processes and to analyze and synthesize observations with theory. (author)

Work-Life Balance among academic staff of the University of Lagos ...

African Journals Online (AJOL)

Work-Life Balance among academic staff of the University of Lagos. ... Abstract. Work-life balance is associated with the maintenance of stability in both one's professional and personal life. It is key to the welfare and, subsequently, job satisfaction and productivity of employees. It is against this understanding that this study ...

E-Counselling Implementation: Students' Life Stories and Counselling Technologies in Perspective

Science.gov (United States)

Kolog, Emmanuel Awuni; Sutinen, Erkki; Vanhalakka-Ruoho, Marjatta

2014-01-01

Given the current global trend of mimicking real life situations into digital counselling games and its related digital counselling platforms, we decided to contextually understand from the Ghanaian senior high school students, their life challenges arising from their life stories. The study also explores the extent to which ICT is currently being…

Implementation of an Outer Can Welding System for Savannah River Site FB-Line

International Nuclear Information System (INIS)

Howard, S.R.

2003-01-01

This paper details three phases of testing to confirm use of a Gas Tungsten Arc (GTA) system for closure welding the 3013 outer container used for stabilization/storage of plutonium metals and oxides. The outer container/lid closure joint was originally designed for laser welding, but for this application, the gas tungsten arc (GTA) welding process has been adapted. The testing progressed in three phases: (1) system checkout to evaluate system components for operational readiness, (2) troubleshooting to evaluate high weld failure rates and develop corrective techniques, and (3) pre-installation acceptance testing

The entropy of the life table: A reappraisal.

Science.gov (United States)

Fernandez, Oscar E; Beltrán-Sánchez, Hiram

2015-09-01

The life table entropy provides useful information for understanding improvements in mortality and survival in a population. In this paper we take a closer look at the life table entropy and use advanced mathematical methods to provide additional insights for understanding how it relates to changes in mortality and survival. By studying the entropy (H) as a functional, we show that changes in the entropy depend on both the relative change in life expectancy lost due to death (e(†)) and in life expectancy at birth (e0). We also show that changes in the entropy can be further linked to improvements in premature and older deaths. We illustrate our methods with empirical data from Latin American countries, which suggests that at high mortality levels declines in H (which are associated with survival increases) linked with larger improvements in e0, whereas at low mortality levels e(†) made larger contributions to H. We additionally show that among countries with low mortality level, contributions of e(†) to changes in the life table entropy resulted from averting early deaths. These findings indicate that future increases in overall survival in low mortality countries will likely result from improvements in e(†). Copyright © 2015 Elsevier Inc. All rights reserved.

Understanding Gas-Phase Ammonia Chemistry in Protoplanetary Disks

Science.gov (United States)

Chambers, Lauren; Oberg, Karin I.; Cleeves, Lauren Ilsedore

2017-01-01

Protoplanetary disks are dynamic regions of gas and dust around young stars, the remnants of star formation, that evolve and coagulate over millions of years in order to ultimately form planets. The chemical composition of protoplanetary disks is affected by both the chemical and physical conditions in which they develop, including the initial molecular abundances in the birth cloud, the spectrum and intensity of radiation from the host star and nearby systems, and mixing and turbulence within the disk. A more complete understanding of the chemical evolution of disks enables a more complete understanding of the chemical composition of planets that may form within them, and of their capability to support life. One element known to be essential for life on Earth is nitrogen, which often is present in the form of ammonia (NH3). Recent observations by Salinas et al. (2016) reveal a theoretical discrepancy in the gas-phase and ice-phase ammonia abundances in protoplanetary disks; while observations of comets and protostars estimate the ice-phase NH3/H2O ratio in disks to be 5%, Salinas reports a gas-phase NH3/H2O ratio of ~7-84% in the disk surrounding TW Hydra, a young nearby star. Through computational chemical modeling of the TW Hydra disk using a reaction network of over 5000 chemical reactions, I am investigating the possible sources of excess gas-phase NH3 by determining the primary reaction pathways of NH3 production; the downstream chemical effects of ionization by ultraviolet photons, X-rays, and cosmic rays; and the effects of altering the initial abundances of key molecules such as N and N2. Beyond providing a theoretical explanation for the NH3 ice/gas discrepancy, this new model may lead to fuller understanding of the gas-phase formation processes of all nitrogen hydrides (NHx), and thus fuller understanding of the nitrogen-bearing molecules that are fundamental for life as we know it.

Understanding the Financial Knowledge Gap: A New Dimension of Inequality in Later Life.

Science.gov (United States)

Khan, Mohammad Nuruzzaman; Rothwell, David W; Cherney, Katrina; Sussman, Tamara

2017-01-01

To understand individuals' financial behaviors, it is important to understand the financial knowledge gap - the distance between one's objective and subjective financial knowledge. Overestimating one's financial knowledge can lead to risky financial behaviors. To date, limited empirical work has examined how financial knowledge gap varies across age groups. We analyze the size and nature of the financial knowledge gap and its variation across age groups. Using nationally representative data, we find robust evidence that older adults overestimate their financial knowledge. Social workers can assess the financial knowledge gap and educate their clients to protect from financial fraud, exploitation, and abuse.

Understanding Participatory Action Research: A Qualitative Research Methodology Option

Science.gov (United States)

MacDonald, Cathy

2012-01-01

Participatory Action Research (PAR) is a qualitative research methodology option that requires further understanding and consideration. PAR is considered democratic, equitable, liberating, and life-enhancing qualitative inquiry that remains distinct from other qualitative methodologies (Kach & Kralik, 2006). Using PAR, qualitative features of an…

The Intestinal Microbiome in Early Life: Health and Disease

Directory of Open Access Journals (Sweden)

Marie-Claire eArrieta

2014-09-01

Full Text Available Human microbial colonization begins at birth and continues to develop and modulate in species abundance for about three years, until the microbiota becomes adult-like. During the same time period, children experience significant developmental changes that influence their current health status as well as their immune system. An ever-expanding number of articles associate several diseases with early life imbalances of the gut microbiota, also referred to as gut microbial dysbiosis. Whether early life dysbiosis precedes and plays a role in disease pathogenesis, or simply originates from the disease process itself is a question that is beginning to be answered in a few diseases, including IBD, obesity and asthma. This review describes the gut microbiome structure and function during the formative first years of life, as well as the environmental factors that determine its composition. It also aims to discuss the recent advances in understanding the role of the early life gut microbiota in the development of immune-mediated, metabolic, and neurological diseases. A greater understanding of how the early life gut microbiota impacts our immune development could potentially lead to novel microbial-derived therapies that target disease prevention at an early age.

Life sciences on the moon

Science.gov (United States)

Horneck, G.

Despite of the fact that the lunar environment lacks essential prerequisites for supporting life, lunar missions offer new and promising opportunities to the life sciences community. Among the disciplines of interest are exobiology, radiation biology, ecology and human physiology. In exobiology, the Moon offers an ideal platform for studies related to the understanding of the principles, leading to the origin, evolution and distribution of life. These include the analysis of lunar samples and meteorites in relatively pristine conditions, radioastronomical search for other planetary systems or Search for Extra-Terrestrial Intelligence (SETI), and studies on the role of radiation in evolutionary processes and on the environmental limits for life. For radiation biology, the Moon provides an unique laboratory with built-in sources for optical as well as ionising radiation to investigate the biological importance of the various components of cosmic and solar radiation. Before establishing a lunar base, precursor missions will provide a characterisation of the radiation field, determination of depth dose distributions in different absorbers, the installation of a solar flare alert system, and a qualification of the biological efficiency of the mixed radiation environment. One of the most challenging projects falls into the domain of ecology with the establishment for the first time of an artificial ecosystem on a celestial body beyond the Earth. From this venture, a better understanding of the dynamics regulating our terrestrial biosphere is expected. It will also serve as a precursor of bioregenerative life support systems for a lunar base. The establishment of a lunar base with eventually long-term human presence will raise various problems in the fields of human physiology and health care, psychology and sociology. Protection guidelines for living in this hostile environment have to be established.

Quality of life in elderly age: areas of concern

Directory of Open Access Journals (Sweden)

Melehin A.I.

2016-03-01

Full Text Available The quality of life in elderly age has special features, depending primarily on the state of health, assessment of the spent life, internal standards, support and ability to operate effectively in changing circumstances. In later ages estimation of quality of life affects the mechanisms of pathogenesis of somatic and mental disorders. Up to date there is no agreement among researchers on criteria of identification and assessment of the quality of life in later ages. This article describes the modern understanding of quality of life and its components. It highlights the issues impeding the improvement of quality of life. The article lists the methods for the evaluation of quality of life in later ages. It also presents the analysis of the main factors affecting the quality of life in elderly patients.

Internet Communication versus Face-to-Face Interaction in Quality of Life

Science.gov (United States)

Lee, Paul S. N.; Leung, Louis; Lo, Venhwei; Xiong, Chengyu; Wu, Tingjun

2011-01-01

This study seeks to understand the role of the Internet in quality of life (QoL). Specifically, it examines the question of whether Internet communication serves, like face-to-face interactions, to enhance quality of life. It is hypothesized that the use of the Internet for interpersonal communication can improve quality of life among Internet…

RNA Relics and Origin of Life

Directory of Open Access Journals (Sweden)

Laurent Vial

2009-07-01

Full Text Available A number of small RNA sequences, located in different non-coding sequences and highly preserved across the tree of life, have been suggested to be molecular fossils, of ancient (and possibly primordial origin. On the other hand, recent years have revealed the existence of ubiquitous roles for small RNA sequences in modern organisms, in functions ranging from cell regulation to antiviral activity. We propose that a single thread can be followed from the beginning of life in RNA structures selected only for stability reasons through the RNA relics and up to the current coevolution of RNA sequences; such an understanding would shed light both on the history and on the present development of the RNA machinery and interactions. After presenting the evidence (by comparing their sequences that points toward a common thread, we discuss a scenario of genome coevolution (with emphasis on viral infectious processes and finally propose a plan for the reevaluation of the stereochemical theory of the genetic code; we claim that it may still be relevant, and not only for understanding the origin of life, but also for a comprehensive picture of regulation in present-day cells.

RNA Relics and Origin of Life

Science.gov (United States)

Demongeot, Jacques; Glade, Nicolas; Moreira, Andrés; Vial, Laurent

2009-01-01

A number of small RNA sequences, located in different non-coding sequences and highly preserved across the tree of life, have been suggested to be molecular fossils, of ancient (and possibly primordial) origin. On the other hand, recent years have revealed the existence of ubiquitous roles for small RNA sequences in modern organisms, in functions ranging from cell regulation to antiviral activity. We propose that a single thread can be followed from the beginning of life in RNA structures selected only for stability reasons through the RNA relics and up to the current coevolution of RNA sequences; such an understanding would shed light both on the history and on the present development of the RNA machinery and interactions. After presenting the evidence (by comparing their sequences) that points toward a common thread, we discuss a scenario of genome coevolution (with emphasis on viral infectious processes) and finally propose a plan for the reevaluation of the stereochemical theory of the genetic code; we claim that it may still be relevant, and not only for understanding the origin of life, but also for a comprehensive picture of regulation in present-day cells. PMID:20111682

Mildew-omics: How global analyses aid the understanding of life and evolution of powdery mildews

Directory of Open Access Journals (Sweden)

Laurence Veronique Bindschedler

2016-02-01

Full Text Available The common powdery mildew plant diseases are caused by ascomycete fungi of the order Erysiphales. Their characteristic life style as obligate biotrophs renders functional analyses in these species challenging, mainly because of experimental constraints to genetic manipulation. Global large-scale (-omics approaches are thus particularly valuable and insightful for the characterisation of the life and evolution of powdery mildews. Here we review the knowledge obtained so far from genomic, transcriptomic and proteomic studies in these fungi. We consider current limitations and challenges regarding these surveys and provide an outlook on desired future investigations on the basis of the various –omics technologies.

Functional linkages for the pace of life, life-history, and environment in birds.

Science.gov (United States)

Williams, Joseph B; Miller, Richard A; Harper, James M; Wiersma, Popko

2010-11-01

For vertebrates, body mass underlies much of the variation in metabolism, but among animals of the same body mass, metabolism varies six-fold. Understanding how natural selection can influence variation in metabolism remains a central focus of Physiological Ecologists. Life-history theory postulates that many physiological traits, such as metabolism, may be understood in terms of key maturational and reproductive characteristics over an organism's life-span. Although it is widely acknowledged that physiological processes serve as a foundation for life-history trade-offs, the physiological mechanisms that underlie the diversification of life-histories remain elusive. Data show that tropical birds have a reduced basal metabolism (BMR), field metabolic rate, and peak metabolic rate compared with temperate counterparts, results consistent with the idea that a low mortality, and therefore increased longevity, and low productivity is associated with low mass-specific metabolic rate. Mass-adjusted BMR of tropical and temperate birds was associated with survival rate, in accordance with the view that animals with a slow pace of life tend to have increased life spans. To understand the mechanisms responsible for a reduced rate of metabolism in tropical birds compared with temperate species, we summarized an unpublished study, based on data from the literature, on organ masses for both groups. Tropical birds had smaller hearts, kidneys, livers, and pectoral muscles than did temperate species of the same body size, but they had a relatively larger skeletal mass. Direct measurements of organ masses for tropical and temperate birds showed that the heart, kidneys, and lungs were significantly smaller in tropical birds, although sample sizes were small. Also from an ongoing study, we summarized results to date on connections between whole-organism metabolism in tropical and temperate birds and attributes of their dermal fibroblasts grown in cell culture. Cells derived from

Life in the lithosphere, kinetics and the prospects for life elsewhere.

Science.gov (United States)

Cockell, Charles S

2011-02-13

The global contiguity of life on the Earth today is a result of the high flux of carbon and oxygen from oxygenic photosynthesis over the planetary surface and its use in aerobic respiration. Life's ability to directly use redox couples from components of the planetary lithosphere in a pre-oxygenic photosynthetic world can be investigated by studying the distribution of organisms that use energy sources normally bound within rocks, such as iron. Microbiological data from Iceland and the deep oceans show the kinetic limitations of living directly off igneous rocks in the lithosphere. Using energy directly extracted from rocks the lithosphere will support about six orders of magnitude less productivity than the present-day Earth, and it would be highly localized. Paradoxically, the biologically extreme conditions of the interior of a planet and the inimical conditions of outer space, between which life is trapped, are the locations from which volcanism and impact events, respectively, originate. These processes facilitate the release of redox couples from the planetary lithosphere and might enable it to achieve planetary-scale productivity approximately one to two orders of magnitude lower than that produced by oxygenic photosynthesis. The significance of the detection of extra-terrestrial life is that it will allow us to test these observations elsewhere and establish an understanding of universal relationships between lithospheres and life. These data also show that the search for extra-terrestrial life must be accomplished by 'following the kinetics', which is different from following the water or energy.

Towards Life Cycle Sustainability Assessment

Directory of Open Access Journals (Sweden)

Marzia Traverso

2010-10-01

Full Text Available Sustainability is nowadays accepted by all stakeholders as a guiding principle for both public policy making and corporate strategies. However, the biggest challenge for most organizations remains in the real and substantial implementation of the sustainability concept. The core of the implementation challenge is the question, how sustainability performance can be measured, especially for products and processes. This paper explores the current status of Life Cycle Sustainability Assessment (LCSA for products and processes. For the environmental dimension well established tools like Life Cycle Assessment are available. For the economic and social dimension, there is still need for consistent and robust indicators and methods. In addition to measuring the individual sustainability dimensions, another challenge is a comprehensive, yet understandable presentation of the results. The “Life Cycle Sustainability Dashboard” and the “Life Cycle Sustainability Triangle” are presented as examples for communication tools for both experts and non expert stakeholders.

Student-Life Stress in Education and Health Service Majors

Science.gov (United States)

Zascavage, Victoria; Winterman, Kathleen G.; Buot, Max; Wies, Jennifer R.; Lyzinski, Natalie

2012-01-01

In order to better understand the effects of student-life stress on Education and Health Service majors (n = 195) at a private, religious, Midwestern university in the USA, we assessed student perception of overall stress level and physical stress level using the Student-life Stress Inventory. The targeted sample consisted of students with…

Understanding the Atheist College Student: A Qualitative Examination

Science.gov (United States)

Mueller, John A.

2012-01-01

The purpose of this study was to examine and understand atheist college students' views on faith and how they experience the college campus as a result. I conducted interviews with 16 undergraduate and graduate self-identified atheist college students. Students discussed losing faith and transitioning to atheism; making meaning of life, death, and…

Female ethnicity: Understanding Muslim immigrant businesswomen in the Netherlands

NARCIS (Netherlands)

Essers, C.; Benschop, Y.W.M.; Doorewaard, J.A.C.M.

2010-01-01

Building on theories of intersectionality, in this article we develop the concept of female ethnicity in order to understand the meanings of femininity for Muslim immigrant businesswomen in the context of entrepreneurship. Through the notion of female ethnicity we analyse four life stories and

The developing hypopharyngeal microbiota in early life

DEFF Research Database (Denmark)

Mortensen, Martin Steen; Brejnrod, Asker Daniel; Roggenbuck, Michael

2016-01-01

BACKGROUND: The airways of healthy humans harbor a distinct microbial community. Perturbations in the microbial community have been associated with disease, yet little is known about the formation and development of a healthy airway microbiota in early life. Our goal was to understand the establi......BACKGROUND: The airways of healthy humans harbor a distinct microbial community. Perturbations in the microbial community have been associated with disease, yet little is known about the formation and development of a healthy airway microbiota in early life. Our goal was to understand...... the establishment of the airway microbiota within the first 3 months of life. We investigated the hypopharyngeal microbiota in the unselected COPSAC2010 cohort of 700 infants, using 16S rRNA gene sequencing of hypopharyngeal aspirates from 1 week, 1 month, and 3 months of age. RESULTS: Our analysis shows...... that majority of the hypopharyngeal microbiota of healthy infants belong to each individual's core microbiota and we demonstrate five distinct community pneumotypes. Four of these pneumotypes are dominated by the genera Staphylococcus, Streptococcus, Moraxella, and Corynebacterium, respectively. Furthermore, we...

Legal guardians understand how children with the human immunodeficiency virus perceive quality of life and stigma.

Science.gov (United States)

Rydström, Lise-Lott; Wiklander, Maria; Ygge, Britt-Marie; Navér, Lars; Eriksson, Lars E

2015-09-01

This aim of this study was to describe how legal guardians assessed health-related quality of life and HIV-related stigma in children with the human immunodeficiency virus (HIV) compared to the children's own ratings. A cross-sectional nationwide study was performed to compare how 37 children aged from eight to 16 years of age with perinatal HIV, and their legal guardians, assessed the children's health-related quality of life and HIV-related stigma. Data were collected using the 37-item DISABKIDS Chronic Generic Module and a short eight-item version of the HIV stigma scale. Intraclass correlations indicated concordance between the legal guardians' ratings and the children's own ratings of the child's health-related quality of life and HIV-related stigma. There were no statistically significant differences between the ratings of the two groups and gender did not have any impact on the results. Both groups indicated that the children had concerns about being open about their HIV status. The results of this study indicated that legal guardians understood how their children perceived their health-related quality of life and HIV-related stigma. The results also indicated the need for interventions to support both the children and legal guardians when it came to disclosing the child's HIV status. ©2015 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.

Reflexive fatherhood in everyday life

DEFF Research Database (Denmark)

Westerling, Allan

2015-01-01

This article looks at fathering practices in Denmark, using the findings from a research project on everyday family life in Denmark. It takes a social psychological perspective and employs discursive psychology and theories about reflexive modernisation. It shows how fathers orient towards intimacy...... in their relationships with their children. Moreover, it discusses how fathers’ relatedness reflects individualisation and detraditionalisation. It is argued that reflexive modernisation entails subjective orientations that enable novel pathways to intimacy in contemporary father–child relationships. Through...... this analysis and discussion, the article offers a way to understand the complexities of fathering in everyday life from the perspective of fathers....

Managing work-life balance of working mothers

OpenAIRE

2014-01-01

M.Comm. (Business Management) Changes in the corporate landscape and an increase in female participation rates in corporate workforces necessitate a better understanding of female career paths and how organisations can accommodate them better. The purpose of this study is to identify the most appropriate work-life balance benefits organisations can offer to female employees to assist them in achieving greater work-life balance. The study further aims to identify learning and development op...

Work-life balance, time and money: identifying the work-life balance priorities of working class workers

OpenAIRE

Warren, Tracey

2017-01-01

This chapter provides an overview of the relative roles played by time and money in debates around work-life balance. It shows how time trumps money in dominant understandings of what ‘work-life’ means and in what parts of our lives are presumed to be in need of balance. Working ‘too many’ hours is seen to be the major challenge for achieving a work-life balance. This is an incomplete account. It is largely about the work-lives of the middle classes and it neglects the priorities of working c...

Virtual Worlds: Relationship Between Real Life and Experience in Second Life

Directory of Open Access Journals (Sweden)

Scott P. Anstadt

2013-09-01

Full Text Available Due to the unique applications of virtual reality in many modern contexts, Second Life (SL offers inimitable opportunities for research and exploration and experiential learning as part of a distance learning curriculum assignment. A review of current research regarding SL examined real world social influences in online interactions and what the effects on users may be. This aids students in understanding the social constructionist perceptions and worldview of those persons they may serve in social services. This suggests the importance of developing an understanding of the relationship between users’ real life (RL and their SL. Some research has begun to reveal the effectiveness of telecommunication and computer simulation with certain clients in the fields of mental health and social work, yet there is a lack of sufficient research done within the context of virtual worlds. The current study surveyed users of several educationally and health focused SIMS (simulations as to what motivates their SL and RL interactions. The data explores associations between users’ RL and their SL in several areas,potentially addressing the future role of educating social work students regarding research methodology in online virtual reality interactions. Implications for social work are discussed including engaging clients using incentives for social participation built into the SL milieu.

The creative pathways of everyday life

DEFF Research Database (Denmark)

Tanggaard, Lene

2015-01-01

interested in the simultaneous development of persons and social practices. Pathways are created in ordinary life; their formation may involve creativity and the improvisational co-creation of opportunities for action. Studying pathways may therefore direct creativity researchers toward the potentials...... in the mundane processes of everyday life is, however, seldom highlighted by researchers working explicitly on creativity. The premise of the present paper is that a focus on everyday life can help us understand creative processes in broader terms. I “creative pathways” may serve as a useful term for researchers...... of creativity in daily life and shed light of the processes of creativity. Creative pathways are present in existing ways of moving and doing things; they are also created in the here-and-now by persons acting in correspondence with the affordances in social practices. A focus on creative pathways is consistent...

Understanding institutional stakeholders’ perspectives on multidrug-resistant bacterial organism at the end of life: a qualitative study

Science.gov (United States)

Heckel, Maria; Herbst, Franziska A; Adelhardt, Thomas; Tiedtke, Johanna M; Sturm, Alexander; Stiel, Stephanie; Ostgathe, Christoph

2017-01-01

Background Information lacks about institutional stakeholders’ perspectives on management approaches of multidrug-resistant bacterial organism in end-of-life situations. The term “institutional stakeholder” includes persons in leading positions with responsibility in hospitals’ multidrug-resistant bacterial organism management. They have great influence on how strategies on multidrug-resistant bacterial organism management approaches in institutions of the public health system are designed. This study targeted institutional stakeholders’ individual perspectives on multidrug-resistant bacterial organism colonization or infection and isolation measures at the end of life. Methods Between March and December 2014, institutional stakeholders of two study centers, a German palliative care unit and a geriatric ward, were queried in semistructured interviews. Interviews were audiotaped, transcribed verbatim, and analyzed qualitatively with the aid of the software MAXQDA for qualitative data analysis using principles of Grounded Theory. In addition, two external stakeholders were interviewed to enrich data. Results Key issues addressed by institutional stakeholders (N=18) were the relevance of multidrug-resistant bacterial organism in palliative and geriatric care, contradictions between hygiene principles and patients’ and family caregivers’ needs and divergence from standards, frame conditions, and reflections on standardization of multidrug-resistant bacterial organism end-of-life care procedures. Results show that institutional stakeholders face a dilemma between their responsibility in protecting third persons and ensuring patients’ quality of life. Until further empirical evidence establishes a clear multidrug-resistant bacterial organism management approach in end-of-life care, stakeholders suggest a case-based approach. Conclusion The institutional stakeholders’ perspectives and their suggestion of a case-based approach advance the development

Understanding institutional stakeholders' perspectives on multidrug-resistant bacterial organism at the end of life: a qualitative study.

Science.gov (United States)

Heckel, Maria; Herbst, Franziska A; Adelhardt, Thomas; Tiedtke, Johanna M; Sturm, Alexander; Stiel, Stephanie; Ostgathe, Christoph

2017-01-01

Information lacks about institutional stakeholders' perspectives on management approaches of multidrug-resistant bacterial organism in end-of-life situations. The term "institutional stakeholder" includes persons in leading positions with responsibility in hospitals' multidrug-resistant bacterial organism management. They have great influence on how strategies on multidrug-resistant bacterial organism management approaches in institutions of the public health system are designed. This study targeted institutional stakeholders' individual perspectives on multidrug-resistant bacterial organism colonization or infection and isolation measures at the end of life. Between March and December 2014, institutional stakeholders of two study centers, a German palliative care unit and a geriatric ward, were queried in semistructured interviews. Interviews were audiotaped, transcribed verbatim, and analyzed qualitatively with the aid of the software MAXQDA for qualitative data analysis using principles of Grounded Theory. In addition, two external stakeholders were interviewed to enrich data. Key issues addressed by institutional stakeholders (N=18) were the relevance of multidrug-resistant bacterial organism in palliative and geriatric care, contradictions between hygiene principles and patients' and family caregivers' needs and divergence from standards, frame conditions, and reflections on standardization of multidrug-resistant bacterial organism end-of-life care procedures. Results show that institutional stakeholders face a dilemma between their responsibility in protecting third persons and ensuring patients' quality of life. Until further empirical evidence establishes a clear multidrug-resistant bacterial organism management approach in end-of-life care, stakeholders suggest a case-based approach. The institutional stakeholders' perspectives and their suggestion of a case-based approach advance the development process of a patient-, family-, staff-, and institutional

Economic modeling for life extension decision making

International Nuclear Information System (INIS)

Farber, M.A.; Harrison, D.L.; Carlson, D.D.

1986-01-01

This paper presents a methodology for the economic and financial analysis of nuclear plant life extension under uncertainty and demonstrates its use in a case analysis. While the economic and financial evaluation of life extension does not require new analytical tools, such studies should be based on the following three premises. First, the methodology should examine effects at the level of the company or utility system, because the most important economic implications of life extension relate to the altered generation system expansion plan. Second, it should focus on the implications of uncertainty in order to understand the factors that most affect life extension benefits and identify risk management efforts. Third, the methodology should address multiple objectives, at a minimum, both economic and financial objectives

Life-cycle assessment of textiles manufacture of polyester shirt (VB)

DEFF Research Database (Denmark)

Othman, Samer; Peter, Oduro Justice; Hassan, Osama

1998-01-01

According to the EDIP (Environmental Design of Industrial Products), It is made possible to perform resource and environmental profile analysis of the 100% polyester shirt. In order to understand the true life-cycle consequences, life-cycle analysis of a typical 100% polyester shirt was carried out...

Canada's looming infrastructure crisis and gas tax agreements : are strategic connections being made?

International Nuclear Information System (INIS)

Kennedy, E.; Roseland, M.; Connelly, S.; Markey, S.

2008-03-01

Canada's municipalities face multiple challenges in relation to the maintenance and development of services and infrastructure. This paper examined the growing infrastructure crisis in relation to sustainable community planning policies, gas tax agreements (GTA) and integrated community sustainability plans (ICSP). The study assessed the degree to which the GTA and ICSP may help to resolve the crisis and move towards the development of more sustainable infrastructure systems. The current need to upgrade or add to the infrastructure inventory represents an opportunity to adopt infrastructure technologies that are sustainable and more environmentally-friendly into municipal systems. The study demonstrated that the GTA and ICSP are financially insufficient. Jurisdictions with an existing capacity to plan and implement sustainability planning are the most successful at engaging with the ICSP process. However, there is no method of ensuring the transfer of innovative greener technologies. There is no overarching national strategy to eliminate or reduce the national infrastructure crisis. A serious national commitment is needed to address Canada's future infrastructure needs. 12 refs., 1 tab.

Brain network of semantic integration in sentence reading: insights from independent component analysis and graph theoretical analysis.

Science.gov (United States)

Ye, Zheng; Doñamayor, Nuria; Münte, Thomas F

2014-02-01

A set of cortical and sub-cortical brain structures has been linked with sentence-level semantic processes. However, it remains unclear how these brain regions are organized to support the semantic integration of a word into sentential context. To look into this issue, we conducted a functional magnetic resonance imaging (fMRI) study that required participants to silently read sentences with semantically congruent or incongruent endings and analyzed the network properties of the brain with two approaches, independent component analysis (ICA) and graph theoretical analysis (GTA). The GTA suggested that the whole-brain network is topologically stable across conditions. The ICA revealed a network comprising the supplementary motor area (SMA), left inferior frontal gyrus, left middle temporal gyrus, left caudate nucleus, and left angular gyrus, which was modulated by the incongruity of sentence ending. Furthermore, the GTA specified that the connections between the left SMA and left caudate nucleus as well as that between the left caudate nucleus and right thalamus were stronger in response to incongruent vs. congruent endings. Copyright © 2012 Wiley Periodicals, Inc.

‘Just give me the best quality of life questionnaire’: the Karnofsky scale and the history of quality of life measurements in cancer trials

Science.gov (United States)

Timmermann, Carsten

2013-01-01

Objectives: To use the history of the Karnofsky Performance Scale as a case study illustrating the emergence of interest in the measurement and standardisation of quality of life; to understand the origins of current-day practices. Methods: Articles referring to the Karnofsky scale and quality of life measurements published from the 1940s to the 1990s were identified by searching databases and screening journals, and analysed using close-reading techniques. Secondary literature was consulted to understand the context in which articles were written. Results: The Karnofsky scale was devised for a different purpose than measuring quality of life: as a standardisation device that helped quantify effects of chemotherapeutic agents less easily measurable than survival time. Interest in measuring quality of life only emerged around 1970. Discussion: When quality of life measurements were increasingly widely discussed in the medical press from the late 1970s onwards, a consensus emerged that the Karnofsky scale was not a very good tool. More sophisticated approaches were developed, but Karnofsky continued to be used. I argue that the scale provided a quick and simple, approximate assessment of the ‘soft’ effects of treatment by physicians, overlapping but not identical with quality of life. PMID:23239756

Perceptions of Parental Awareness of Emotional Responses to Stressful Life Events

OpenAIRE

Jobe-Shields, Lisa; Parra, Gilbert R.; Buckholdt, Kelly E.

2013-01-01

There is a need to better understand family processes related to recovery from past stressful life events. The present study aimed to investigate links between perceptions of parental awareness regarding stressful life events, continued event-related rumination, and current symptoms of depression. Students at a diverse, urban university completed a life events checklist and a semi-structured interview regarding family processing of stressful life events, as well as self-report measures of eve...

Genre, the organization of knowledge and everyday life

DEFF Research Database (Denmark)

Andersen, Jack

2017-01-01

as a communicative activity in everyday life. Method. This is a text-based argument which pulls together different sources for developing and discussing the contention. Analysis. I will start out with some brief reflections on digital media and communicative interaction. From there I will look into some steps...... already made toward understanding knowledge organization as an everyday activity, before providing some examples of how the organization of knowledge in digital media can be understood as genre-based communication in everyday life. Results. Due to the saturation of digital media in everyday life, genre...

Stress-life interrelationships associated with alkaline fuel cells

Science.gov (United States)

Thaller, Lawrence H.; Martin, Ronald E.; Stedman, James K.

1987-01-01

A review is presented concerning the interrelationships between applied stress and the expected service life of alkaline fuel cells. Only the physical, chemical, and electrochemical phenomena that take place within the fuel cell stack portion of an overall fuel cell system will be discussed. A brief review will be given covering the significant improvements in performance and life over the past two decades as well as summarizing the more recent advances in understanding which can be used to predict the performance and life characteristics of fuel cell systems that have yet to be built.

Understanding the influence of climate change on the embodied energy of water supply.

Science.gov (United States)

Mo, Weiwei; Wang, Haiying; Jacobs, Jennifer M

2016-05-15

The current study aims to advance understandings on how and to what degree climate change will affect the life cycle chemical and energy uses of drinking water supply. A dynamic life cycle assessment was performed to quantify historical monthly operational embodied energy of a selected water supply system located in northeast US. Comprehensive multivariate and regression analyses were then performed to understand the statistical correlation among monthly life cycle energy consumptions, three water quality indicators (UV254, pH, and water temperature), and five climate indicators (monthly mean temperature, monthly mean maximum/minimum temperatures, total precipitation, and total snow fall). Thirdly, a calculation was performed to understand how volumetric and total life cycle energy consumptions will change under two selected IPCC emission scenarios (A2 and B1). It was found that volumetric life cycle energy consumptions are highest in winter months mainly due to the higher uses of natural gas in the case study system, but total monthly life cycle energy consumptions peak in both July and January because of the increasing water demand in summer months. Most of the variations in chemical and energy uses can be interpreted by water quality and climate variations except for the use of soda ash. It was also found that climate change might lead to an average decrease of 3-6% in the volumetric energy use of the case study system by the end of the century. This result combined with conclusions reached by previous climate versus water supply studies indicates that effects of climate change on drinking water supply might be highly dependent on the geographical location and treatment process of individual water supply systems. Copyright © 2016 Elsevier Ltd. All rights reserved.

Understanding Of Wisdom In The Book Of Daniel

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Peniel C.D. Maiaweng

2016-03-01

Full Text Available Daniel, Hananiah, Misael, and Azariah were young Jewish people who had been taken to Babylon in captivity. They truly obeyed God in their daily life and did not defile themselves with the king’s food and wine. God honored their decision so He gave them wisdom, that is intellectual ability (knowledge and understanding of all kinds of literature and learning and understanding visions and dreams of all kinds. Their response to the wisdom from God was having a good life style, submitting to God, and carrying burdens. To continue the wisdom from God, they lived in unity, depended on God and had God’s spirit in them. In doing their job, they spoke with wisdom and tact and worked honestly. In working with the king, they made a courageous decision not to worship the image of god and not to follow the king’s command. In the king’s palace, Daniel did not think for himself only, but had a burden to pray for Jerusalem, represent his nation before God, and fast for the future. 

Understanding the private worlds of physicians, nurses, and parents: a study of life-sustaining treatment decisions in Italian paediatric critical care.

Science.gov (United States)

Carnevale, Franco A; Benedetti, Monica; Bonaldi, Amabile; Bravi, Elena; Trabucco, Gaetano; Biban, Paolo

2011-12-01

This study's aim was to describe: (a) How life-sustaining treatment (LST) decisions are made for critically ill children in Italy; and (b) How these decisional processes are experienced by physicians, nurses and parents. Focus groups with 16 physicians and 26 nurses, and individual interviews with 9 parents were conducted. Findings uncovered the 'private worlds' of paediatric intensive care unit (PICU) physicians, nurses and parents; they all suffer tremendously and privately. Physicians struggle with the weight of responsibility and solitude in making LST decisions. Nurses struggle with feelings of exclusion from decisions regarding patients and families that they care for. Physicians and nurses are distressed by legal barriers to LST withdrawal. Parents struggle with their dependence on physicians and nurses to provide care for their child and strive to understand what is happening to their child. Features of helpful and unhelpful communication with parents are highlighted, which should be considered in educational and practice changes.

Microbial Life in the Subseafloor at Mid-Ocean Ridges: A Key to Understanding Ancient Ecosystems on Earth and Elsewhere?

Science.gov (United States)

Baross, J. A.; Delaney, J. R.

2001-12-01

Some planets and moons in our solar system were similar to Earth in their geological properties during the first few hundred million years after accretion. This is the period when life arose and became established on Earth. It follows that understanding the geophysical and geochemical characteristics of early Earth could provide insight into life-supporting environments on other solar bodies that have not evolved "Garden of Eden" conditions. Hydrothermal systems are primordial and their emergence coincided with the accumulation of liquid water on Earth. The interactions of water and rock associated with hydrothermal systems result in predictable suites of dissolved elements and volatiles. While the concentrations of these chemicals vary at different vent locations and were certainly different during the early Archaean, the overall chemical composition of aqueous hydrothermal fluid is likely to be the same because of the basaltic nature of oceanic crust. In present-day hydrothermal systems, those environments not contaminated by electron acceptors produced from pelagic photosynthesis would most closely mimic the earliest conditions on Earth. These conditions include the subseafloor and high temperature, anaerobic environments associated with hydrothermal systems. The microorganisms associated with these environments derive energy from sulfur, iron, hydrogen and organic compounds. New seafloor eruptions and diffuse flow vents provide unprecedented access to deep subseafloor microbial communities. For example, 12 new eruptions have occurred in the past 15 years including five in the Northeast Pacific. Hyperthermophiles were isolated from 5-30oC diffuse vent fluids from new eruption sites at CoAxial within months of the June, 1993 eruption and from the 1998 eruption at Axial Volcano, and from plume fluids within days of the February, 1996 eruption at the N. Gorda Ridge. The presence of such organisms in fluids that are 20 to 50°C below their minimum growth temperature

Research on Language of Perception Still-Life as a Visual Aphorism

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Anatolij P. Suprun

2011-01-01

Full Text Available This article describes a categorical structure of perception of still-life painting. Analysis is done on the system of visual opposition elements in still-life. A still-life is considered a "perceptual statement about the world", and a "visual aphorism" The research is based on such methods as: semantic spaces constructing and their transformation at introduction of additional elements in still-lifes. It also gives full analysis of an interpretation of complex images and understanding of types of still-life as a visual hermeneutics.

DETERMINANTS OF ENTERPRISES LIFE CYCLE IN MODERN CONDITIONS OF DEVELOPMENT

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Alla Polianska

2016-03-01

Full Text Available In the article the theoretical basis of organization life cycle research as well as the particularly of the organization life cycle concept implementation for solving of modern targets of enterprises and organizations development are highlighted. The determinants of one life cycle stage transformation to the other at the enterprises, that allows to better understand the conditions of its functioning and to identify factors that affect the viability of the company and its duration, are considered. Management technologies at different stages of organizations life cycle are proposed. Keywords: enterprise, development, organizations life cycle, determinants, Oil and Gas company JEL: M 20

Conceptual Principles of Quality of Life: An Empirical Exploration

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Bramston, P.; Chipuer, H.; Pretty, G.

2005-01-01

Background: Quality of life is a popular measure of outcomes and its widespread use has led to recent calls for a better understanding of the construct, emphasizing the need to build a substantial body of knowledge around what determines perceptions of life quality. Three widely reported and used conceptual principles are examined in this study.…

Models of the Organizational Life Cycle: Applications to Higher Education.

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Cameron, Kim S.; Whetten, David A.

1983-01-01

A review of models of group and organization life cycle development is provided and the applicability of those models for institutions of higher education are discussed. An understanding of the problems and characteristics present in different life cycle stages can help institutions manage transitions more effectively. (Author/MLW)

To Fairly Tell: Social Mobility, Life Histories, and the Anthropologist

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Benei, Veronique

2010-01-01

This article focuses on social agents' own understandings of socio-economic mobility and social achievement, exploring the possibilities offered by the tool of "family" life history in the context of formerly Untouchable communities in western India, Maharashtra. While arguing in favour of family life histories as both resource and…

The specific Life Orientation needs of Grade 9 learners in the Vaal ...

African Journals Online (AJOL)

We report on a study aimed at understanding adolescence as a period of heightened vulnerability, and investigate Life Orientation as a possible means of addressing the risk associated with adolescence. However, if Life Orientation is to be an effective solution to the problem, it needs to respond to Life Orientation needs as ...

Exploratory Study of Depressed Adolescents’ Life Narratives

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Aurore Boulard

2015-06-01

Full Text Available Objective: The aim of this study was to explore the life stories of depressive adolescents and compare them with non-clinical adolescents’ life stories. Methods: For this purpose, we compared 20 life stories of hospitalized adolescents suffering from major depressive episode with 40 life stories of adolescents attending school divided into two groups: 20 non-depressed and 20 depressed adolescents. Results: Results showed that life stories differed as a function of psychopathology. Depressed hospitalized adolescents spoke about their disease and defined themselves by their depression. The depressed adolescents in school concentrated on schooling and school achievements, while the non-depressed group defined themselves by their family, friends and inclusion in a peer group. Conclusion: These analyses allowed us to highlight specific themes mentioned by each of the three groups of adolescents. Although life stories are personal and unique, analysis of such stories allows us to better understand the daily reality of depressive adolescents and the relationships between the life events they experience, daily stressors, depression and how they construct their personal history.

The greater tuberosity angle: a new predictor for rotator cuff tear.

Science.gov (United States)

Cunningham, Gregory; Nicodème-Paulin, Emilie; Smith, Margaret M; Holzer, Nicolas; Cass, Benjamin; Young, Allan A

2018-04-24

The implication of scapular morphology in rotator cuff tears has been extensively studied. However, the role of the greater tuberosity (GT) should be of equal importance. The aim of this study was to propose a new radiographic marker, the GT angle (GTA), which measures the position of the GT in relation to the center of rotation of the humeral head. The hypothesis was that a higher angle value would be associated with a higher likelihood in detecting a rotator cuff tear. During 1 year, patients were prospectively recruited from a single institution specialized shoulder clinic in 2 different groups. The patient group consisted of individuals with a degenerative rotator cuff tear involving at least the supraspinatus. The control group consisted of individuals with no rotator cuff pathology. Individuals in both groups with congenital, post-traumatic, or degenerative alterations of the proximal humerus were excluded. The GTA was measured on an anteroposterior shoulder x-ray image with the arm in neutral rotation by 3 observers at 2 different times. The study recruited 71 patients (33 patients, 38 controls). Mean GTA value was 72.5° (range, 67.6°-79.2°) in patients and 65.2° (range, 55.8°-70.5°) for controls (P rotator cuff tear (P rotator cuff tears. The GTA is a reliable radiographic marker, with more than 70° being highly predictive in detecting such lesions. Copyright © 2018 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved.

Comparison of glutaraldehyde and carbodiimides to crosslink tissue engineering scaffolds fabricated by decellularized porcine menisci

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Gao, Shuang; Yuan, Zhiguo; Guo, Weimin; Chen, Mingxue; Liu, Shuyun; Xi, Tingfei; Guo, Quanyi

2017-01-01

The objectives of this study were to fabricate porous scaffolds using decellularized meniscus, and to explore a preferable crosslinking condition to enhance mechanical properties of scaffolds. Moreover, the microstructure, porosity, biodegradation and cytotoxicity were also evaluated. EDAC or GTA in different concentration was used to crosslink scaffolds. FTIR demonstrated functional groups change in crosslinking process. SEM photography showed that crosslinked scaffolds had blurry edges, which resulted scaffolds crosslinked by 1.2 mol/l EDAC had smaller porosity than other groups. The structure change enhanced antidegradation property. After immersing in enzyme solution for 96 h, scaffolds crosslinked by GTA and EDAC could maintain their mass > 70% and 80%. Most importantly, mechanical properties of crosslinked scaffolds were also improved. Uncrosslinked Scaffolds had only 0.49 kPa in compression modulus and 12.81 kPa in tensile modulus. The compression and tensile modulus of scaffolds crosslinked by 1.0% GTA were 1.42 and 567.44 kPa respectively. The same value of scaffolds crosslinked by 1.2 mol/l EDAC were 1.49 and 532.50 kPa. Scaffolds crosslinked by 1.0% and 2.5% GTA were toxic to cells, while EDAC groups showed no cytotoxicity. Chondrocytes could proliferate and infiltrate within scaffolds after seeding. Overall, 1.2 mol/l EDAC was a preferable crosslinking condition. - Highlights: • Porous meniscus scaffolds were fabricated using decellularized meniscus tissue. • Mechanical properties of meniscus scaffolds were enhanced by chemical crosslinking. • The crosslinked scaffold showed enhanced anti-degradation properties. • Chondrocytes could infiltrate and proliferate within crosslinked scaffolds.

Comparison of glutaraldehyde and carbodiimides to crosslink tissue engineering scaffolds fabricated by decellularized porcine menisci

Energy Technology Data Exchange (ETDEWEB)

Gao, Shuang [Center for Biomedical Material and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871 (China); Yuan, Zhiguo; Guo, Weimin; Chen, Mingxue; Liu, Shuyun [Beijing Key Lab of Regenerative Medicine in Orthopaedics, Institute of Orthopaedics, Chinese PLA General Hospital, Beijing 100853 (China); Key Laboratory of Musculoskeletal Trauma & War Injuries, Institute of Orthopaedics, Chinese PLA General Hospital, Beijing 100853 (China); Xi, Tingfei, E-mail: tingfeixi@163.com [Center for Biomedical Material and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871 (China); Shenzhen Institute, Peking University, Shenzhen 518057 (China); Guo, Quanyi, E-mail: doctorguo_301@163.com [Beijing Key Lab of Regenerative Medicine in Orthopaedics, Institute of Orthopaedics, Chinese PLA General Hospital, Beijing 100853 (China); Key Laboratory of Musculoskeletal Trauma & War Injuries, Institute of Orthopaedics, Chinese PLA General Hospital, Beijing 100853 (China)

2017-02-01

The objectives of this study were to fabricate porous scaffolds using decellularized meniscus, and to explore a preferable crosslinking condition to enhance mechanical properties of scaffolds. Moreover, the microstructure, porosity, biodegradation and cytotoxicity were also evaluated. EDAC or GTA in different concentration was used to crosslink scaffolds. FTIR demonstrated functional groups change in crosslinking process. SEM photography showed that crosslinked scaffolds had blurry edges, which resulted scaffolds crosslinked by 1.2 mol/l EDAC had smaller porosity than other groups. The structure change enhanced antidegradation property. After immersing in enzyme solution for 96 h, scaffolds crosslinked by GTA and EDAC could maintain their mass > 70% and 80%. Most importantly, mechanical properties of crosslinked scaffolds were also improved. Uncrosslinked Scaffolds had only 0.49 kPa in compression modulus and 12.81 kPa in tensile modulus. The compression and tensile modulus of scaffolds crosslinked by 1.0% GTA were 1.42 and 567.44 kPa respectively. The same value of scaffolds crosslinked by 1.2 mol/l EDAC were 1.49 and 532.50 kPa. Scaffolds crosslinked by 1.0% and 2.5% GTA were toxic to cells, while EDAC groups showed no cytotoxicity. Chondrocytes could proliferate and infiltrate within scaffolds after seeding. Overall, 1.2 mol/l EDAC was a preferable crosslinking condition. - Highlights: • Porous meniscus scaffolds were fabricated using decellularized meniscus tissue. • Mechanical properties of meniscus scaffolds were enhanced by chemical crosslinking. • The crosslinked scaffold showed enhanced anti-degradation properties. • Chondrocytes could infiltrate and proliferate within crosslinked scaffolds.

Bryophyte in the Beginning of Terrestrial Life

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Özcan ŞİMŞEK

2016-12-01

Full Text Available The beginning of life has been wondered by human beings since ancient ages. The widely accepted opinion is that life began in water and after that landed. In this process, the landing of plants and adapting to terrestrial life of plants are important stages. The last 20 years it’s been done many researches to find out the relationship of bryophytes and tracheophytes. The results of these researches revealed that in evolutionary development process bryophytes and tracheophytes are sister groups. Thesis about earliest land plants are bryophytes is widely accepted recent years. To understand evolutionary process and plants of today’s better, researches about bryophytes must increase.

Quality of work life: experiences of Iranian nurses.

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Vagharseyyedin, Seyyed Abolfazl; Vanaki, Zohreh; Mohammadi, Eesa

2011-03-01

The purpose of this qualitative study was to describe the experiences of Iranian nurses concerning their quality of work life. A purposive sample of nurses (n = 14) was recruited from two university hospitals. The data were collected through unstructured interviews and were analyzed by using qualitative content analysis. The results indicated that the participants discerned their quality of work life by assessing how favorable were their working conditions, the level of fulfilment of their personal needs, and the impact of their working conditions on their private life and their social life. Three main themes were identified: quality of work life, as experienced from a personal perspective; quality of work life, as experienced from a sociocultural perspective; and quality of work life, as experienced from an organizational-professional perspective. The results of the present study will help Iranian nurse administrators to adopt effective strategies in order to improve nurses' quality of work life. Future research can broaden the scope of the current results and offer a more comprehensive understanding of nurses' quality of work life. © 2011 Blackwell Publishing Asia Pty Ltd.

Inner and Outer Life at Work

DEFF Research Database (Denmark)

Lundgaard Andersen, Linda

2012-01-01

involving people to people interactions offered by psychodynamic theories and methods take up a pivotal position. Psychoanalytic organisational and work life research explores how work, organisations and individuals are affected by psychic dynamics, the influence of the unconscious in the forms of human...... development and interaction situated in a societal context. Based on this substantial work I draw upon two influential psychoanalytical positions—the British Tavistock position and German psychoanalytic social psychology in order to situate and identify how to understand the inner and outer life at work...

Understanding peace a comprehensive introduction

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Fox, Michael Allen

2013-01-01

Understanding Peace: A Comprehensive Introduction fills the need for an original, contemporary examination of peace that is challenging, informative, and empowering. This well-researched, fully documented, and highly accessible textbook moves beyond fixation on war to highlight the human capacity for nonviolent cooperation in everyday life and in conflict situations. After deconstructing numerous ideas about war and explaining its heavy costs to humans, animals, and the environment, discussion turns to evidence for the existence of peaceful societies. Further topics include the role of nonviolence in history, the nature of violence and aggression, and the theory and practice of nonviolence. The book offers two new moral arguments against war, and concludes by defining peace carefully from different angles and then describing conditions for creating a culture of peace. Understanding Peace brings a fresh philosophical perspective to discussions of peace, and also addresses down-to-earth issues about effecting ...

How to achieve a work-life balance.

Science.gov (United States)

Westwood, Claire

2010-11-01

Understanding who you are in terms of your values, skills, passions and motivations will help you to make the most of your abilities and improve your work-life balance. This article sets out steps to achieve this.

Understanding intellectual disability through RASopathies.

Science.gov (United States)

San Martín, Alvaro; Pagani, Mario Rafael

2014-01-01

Intellectual disability, commonly known as mental retardation in the International Classification of Disease from World Health Organization, is the term that describes an intellectual and adaptive cognitive disability that begins in early life during the developmental period. Currently the term intellectual disability is the preferred one. Although our understanding of the physiological basis of learning and learning disability is poor, a general idea is that such condition is quite permanent. However, investigations in animal models suggest that learning disability can be functional in nature and as such reversible through pharmacology or appropriate learning paradigms. A fraction of the cases of intellectual disability is caused by point mutations or deletions in genes that encode for proteins of the RAS/MAP kinase signaling pathway known as RASopathies. Here we examined the current understanding of the molecular mechanisms involved in this group of genetic disorders focusing in studies which provide evidence that intellectual disability is potentially treatable and curable. The evidence presented supports the idea that with the appropriate understanding of the molecular mechanisms involved, intellectual disability could be treated pharmacologically and perhaps through specific mechanistic-based teaching strategies. Copyright © 2014 Elsevier Ltd. All rights reserved.

Population momentum across vertebrate life histories

Science.gov (United States)

Koons, D.N.; Grand, J.B.; Arnold, J.M.

2006-01-01

Population abundance is critically important in conservation, management, and demographic theory. Thus, to better understand how perturbations to the life history affect long-term population size, we examined population momentum for four vertebrate classes with different life history strategies. In a series of demographic experiments we show that population momentum generally has a larger effect on long-term population size for organisms with long generation times than for organisms with short generation times. However, patterns between population momentum and generation time varied across taxonomic groups and according to the life history parameter that was changed. Our findings indicate that momentum may be an especially important aspect of population dynamics for long-lived vertebrates, and deserves greater attention in life history studies. Further, we discuss the importance of population momentum in natural resource management, pest control, and conservation arenas. ?? 2006 Elsevier B.V. All rights reserved.

Understanding wellness center loyalty through lifestyle analysis.

Science.gov (United States)

Suresh, Satya; Ravichandran, Swathi; P, Ganesan

2011-01-01

Many changes taking place at a macro-level in Indian society along with the popularity of services that are native to India, such as Yoga and Ayurveda, have generated significant interest in wellness services. To assist wellness centers in gaining loyal clients, the goal of this study was to understand the influence of customer lifestyle factors on wellness center loyalty. The activities, interests, and opinions model was used to understand the lifestyles of wellness center clients. Data were collected from clients of five wellness centers. Regression results indicate that overworked individuals and those seeking a balance between work and family life would be the most loyal to wellness centers. Managerial implications of results are discussed.

Frendship, diversity and fear: young people’s life views and life values in a multicultural society

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Gunnar J. Gunnarsson

2015-08-01

Full Text Available This article introduces initial findings from a study on young people‘s (18 years and older life views and life values in Iceland. The research project is located within a broad theoretical framework and uses interdisciplinary approaches of religious education, multicultural studies and pedagogy. Methodological approaches are both quantitative and qualitative. The first part of the research is a survey which was conducted among altogether 904 students in seven upper secondary schools in the Reykjavík area and other areas of Iceland in 2011 and 2012. In addition to covering measures of background variables and religious affiliations, statements in the survey included themes such as views of life, self-understanding, relation to others, values and value judgments, religions, and diversity and social change. The article focuses especially on findings from the survey related to friendship, attitudes towards diversity, fear and insecurity in a multicultural society. The findings indicate that the participants generally have positive attitudes towards diversity. The majority of participants find it inspiring to have friends of different origins and find it important to respect different cultural and religious traditions. The majority of participants also have strong opinions against racism and bullying. Friends are important and most of the participants are of the opinion that friends are one of the things that provide security. At the same time only a minority is afraid of being unpopular, losing the confidence of their friends or being bullied. But when the fear is about disgracing oneself or about not being able to meet the requirements at school the proportion is higher. Although the economic crisis in Iceland seems to have an effect on the life of the young people answering the survey, most of them are of the opinion that the future holds a lot of opportunities. The results are useful for further discussions on young people´s life views, self-understanding

Life satisfaction, ethnicity and neighbourhoods: Is there an effect of neighbourhood ethnic composition on life satisfaction?

Science.gov (United States)

Knies, Gundi; Nandi, Alita; Platt, Lucinda

2016-11-01

Immigrants and ethnic minorities tend to have lower life satisfaction than majority populations. However, current understanding of the drivers of these gaps is limited. Using a rich, nationally representative data set with a large sample of ethnic minorities and matched neighbourhood characteristics, we test whether first and second generation minorities experience lower life satisfaction once accounting for compositional differences and whether, specifically, neighbourhood deprivation impacts their wellbeing. We further investigate whether a larger proportion of own ethnic group in the neighbourhood improves satisfaction. We find life satisfaction is lower among ethnic minorities, and especially for the second generation, even controlling for individual and area characteristics. Neighbourhood concentration of own ethnic group is, however, associated with higher life satisfaction for Black Africans and UK born Indians and Pakistanis. The effect for Black Africans may stem from selection into areas, but findings for Indians and Pakistanis are robust to sensitivity tests. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Thermocapillary and arc phenomena in stainless steel welds

Energy Technology Data Exchange (ETDEWEB)

Pierce, Stanley W. [Colorado School of Mines, Golden, CO (United States)

1993-01-01

Goal was to study effect of power level and distribution on thermocapiilary-induced weld shape and of arc factors on weld shape. Thermocapillarity was apparent in both conduction mode EB welds and GTA welds, particularly in the former. A non-Gaussian arc distribution is suggested for accounting for the differences between the twoss processes. At higher current levels (200--300 A), plasma shear force also contributes to weld shape development. Evidence suggests that thermocapillary flow reversal is not a factor in normal GTA welds; EDB flow reversal occurs only at high power density levels where the keyhole mode is present.

Life Sciences—Life Writing: PTSD as a Transdisciplinary Entity between Biomedical Explanation and Lived Experience

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Norbert W. Paul

2015-12-01

Full Text Available Since the second half of the 20th century, the life sciences have become one of the dominant explanatory models for almost every aspect of human life. Hand in hand with biomedical developments and technologies, the life sciences are constantly shaping and reshaping human lives and changing human biographies in manifold ways. The orientation towards life sciences and biomedicine from the very beginning to the end of human life is driven by the utopian notion that all forms of contingency could be technologically and medically controlled. This paper addresses the interrelatedness of life sciences and human biographies in a field where contingency and risk become essential and existential parts of lived experience: post-traumatic stress disorder (PTSD. On the one hand, this diagnostic entity is related to (neuro-biological underpinnings of (a lack of psychic resilience as well as to those of contemporary pharmacotherapy. On the other hand, PTSD is also understood as based on a traumatic life event, which can be accessed through and addressed by talk therapy, particularly narrative exposure therapy (NET. We argue that a novel focus on concepts of narrativity will generate pathways for an interdisciplinary understanding of PTSD by linking biological underpinnings from neurobiological findings, to brain metabolism and pharmacotherapy via the interface of psychotherapy and the specific role of narratives to the lived experience of patients and vice versa. The goal of our study is to demonstrate why therapies such as psychotherapy or pharmacotherapy are successful in controlling the disease burden of PTSD to some extent, but the restitutio ad integrum, the reestablishing of the bodily and psychic integrity remains out of reach for most PTSD patients. As a test case, we discuss the complementary methods of Traditional Chinese Medicine (TCM and the established procedures of talk therapy (NET to show how a methodological focus on narratives enhanced by

Dynamic heterogeneity and life history variability in the kittiwake

DEFF Research Database (Denmark)

Steiner, Uli; Tuljapurkar, Shripad; Orzack, Steven Hecht

2010-01-01

1. Understanding the evolution of life histories requires an assessment of the process that generates variation in life histories. Within-population heterogeneity of life histories can be dynamically generated by stochastic variation of reproduction and survival or be generated by individual...... differences that are fixed at birth. 2. We show for the kittiwake that dynamic heterogeneity is a sufficient explanation of observed variation of life histories. 3. The total heterogeneity in life histories has a small contribution from reproductive stage dynamics and a large contribution from survival...... differences. We quantify the diversity in life histories by metrics computed from the generating stochastic process. 4. We show how dynamic heterogeneity can be used as a null model and also how it can lead to positive associations between reproduction and survival across the life span. 5. We believe our...

[The Woman and the Care of Life. Historical Understanding and Future Perspectives].

Science.gov (United States)

Massé García, M Carmen

2017-01-01

Over the ages of humanity, women has established a special relationship life care's with the most vulnerable. Women dedicated to the professional care have always existed, also to the unpaid home care of the sick, elderly, with some disability, and children. This study has been carried out a historical and current verification of this question, marking its most characteristic and significant features. From that perspective, we tried to answer these key questions: causes that have motivated this fact, its social consequences and, finally, the most important future implications for all, men and women that, surely, we will be caregivers and strapped for care in our illness.

The Life Mission Theory II. The Structure of the Life Purpose and the Ego

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Soren Ventegodt

2003-01-01

course, but it is centered on the optimal verbal expression of the life mission. Such an ego is not in conflict with one�s true self, but supports the life and wholeness of the person, although in an invisible and seamless way. The more developed the person, the more talents are taken into use. So although the core of existence remains the same throughout life, the healthy person continues to grow. As the number of talents we can call on is unlimited, the journey ends only at death. Understanding the concept of the ego, it is very easy for the physician to motivate the patient to go through a lot of difficulties in order to grow and develop, and when the patient fully understands the concept of the ego and the true self (higher self, the patient gets a strong feeling of direction in personal development, and a motivation to fight the internal obstacles for quality of life, health, and the ability to function.

Population-specific life histories contribute to metapopulation viability

Science.gov (United States)

Halsey, Samniqueka J.; Bell, Timothy J.; McEachern, A. Kathryn; Pavlovic, Noel B.

2016-01-01

Restoration efforts can be improved by understanding how variations in life-history traits occur within populations of the same species living in different environments. This can be done by first understanding the demographic responses of natural occurring populations. Population viability analysis continues to be useful to species management and conservation with sensitivity analysis aiding in the understanding of population dynamics. In this study, using life-table response experiments and elasticity analyses, we investigated how population-specific life-history demographic responses contributed to the metapopulation viability of the Federally threatened Pitcher's thistle (Cirsium pitcheri). Specifically, we tested the following hypotheses: (1) Subpopulations occupying different environments within a metapopulation have independent demographic responses and (2) advancing succession results in a shift from a demographic response focused on growth and fecundity to one dominated by stasis. Our results showed that reintroductions had a positive contribution to the metapopulation growth rate as compared to native populations which had a negative contribution. We found no difference in succession on the contribution to metapopulation viability. In addition, we identified distinct population-specific contributions to metapopulation viability and were able to associate specific life-history demographic responses. For example, the positive impact of Miller High Dunes population on the metapopulation growth rate resulted from high growth contributions, whereas increased time of plant in stasis for the State Park Big Blowout population resulted in negative contributions. A greater understanding of how separate populations respond in their corresponding environment may ultimately lead to more effective management strategies aimed at reducing extinction risk. We propose the continued use of sensitivity analyses to evaluate population-specific demographic influences on

Facing Forward Series: Life After Cancer Treatment

Science.gov (United States)

... treatment Coping with your feelings Going back to work and relating with friends and coworkers Show this booklet to the people who are close to you so they understand what life is like after cancer treatment. Take it with ...

Determining the quality of life in persons with acquired brain injury

OpenAIRE

Balanč, Mateja

2017-01-01

Identifying and assessing the quality of life of persons with acquired brain injury is an important element of rehabilitation, and enables assistance and support to both the injured and their families. By identifying and assessing quality of life, we can better understand the impact of injuries on the individual and his/her life. Different levels of injuries can severely affect cognitive, physical, emotional-behavioral and social life not only of a injured person but also of members of his f...

Life Satisfaction in Women With Breast Cancer1

Directory of Open Access Journals (Sweden)

Solange Fonseca

2014-12-01

Full Text Available It is well known that breast cancer carries many psychosocial consequences. For a deeper understanding of this topic, this study aims to analyze the relationship between life satisfaction, meaning in life, optimism, body image and depression in 55 women with breast cancer, organized into two groups: mastectomized and submitted to conservative surgery. The variables were characterized based on the results from the Auto-Actualização-SentidoVida [Self-Actualization-Life Meaning] sub-scale, the Escala de Otimismo [Optimism scale], the Body Image Scale, the Hospital Anxiety and Depression Scale and the Escala de Satisfação com a Vida [Life satisfaction scale]. Meaning in life and optimism were positively correlated with life satisfaction. Higher depression and body image disturbance appeared associated with lower life satisfaction. Body image disturbance was higher in mastectomized women. It was concluded that women submitted to conservative surgery do not have more life satisfaction than mastectomized women, requiring equal attention in terms of preventing depression and promoting positive variables.

The influence of work-life balance, choice and a meaningful location on work transitions.

Science.gov (United States)

Lisson, Selene; Mee, Laura; Gilbert, Kristen

2013-01-01

To explore career transitions using an occupational perspective. One man shared his views on career transitions to elaborate concepts on work-life balance, choice and meaning. Narrative reflection and theoretical exploration of occupational concepts underscoring career transitions. Three concepts are important to understanding career transitions, work-life balance, making meaning choices, and place. Further development in work transitions can be elaborated using an occupational understanding.

Shape understanding system machine understanding and human understanding

CERN Document Server

Les, Zbigniew

2015-01-01

This is the third book presenting selected results of research on the further development of the shape understanding system (SUS) carried out by authors in the newly founded Queen Jadwiga Research Institute of Understanding. In this book the new term Machine Understanding is introduced referring to a new area of research aiming to investigate the possibility of building machines with the ability to understand. It is presented that SUS needs to some extent mimic human understanding and for this reason machines are evaluated according to the rules applied for the evaluation of human understanding. The book shows how to formulate problems and how it can be tested if the machine is able to solve these problems.    

Understanding thermodynamic relationships and geochemical mass balances from catchment to coast: A tribute to the life and career of Owen P. Bricker III

Science.gov (United States)

Bricker, Suzanne B.; Mackenzie, Fred T.; Baron, Jill S.; Price, Jason

2014-01-01

This special volume of aquatic geochemistry is dedicated to the memory of Owen Peterson Bricker III (1936–2011) and serves as a tribute to his life and career. Owen had a distinguished and productive research career in both academics at Johns Hopkins University (Fig. 1) and as a public servant with the Maryland Geological Survey, the US Environmental Protection Agency, and the US Geological Survey. He was a pioneer and leader in aqueous geochemistry, who applied a study approach that quantified mineral weathering reactions and equilibrium thermodynamic relations to better understand the chemical evolution of stream water in small watersheds. He will be especially remembered for his efforts to establish rigorous field studies in small catchments around the United States as a means of quantifying the sources of acid-neutralizing capacity that affect the chemical status and biological health of natural waters.

Laypeople's understanding of radioactivity and radiation

International Nuclear Information System (INIS)

Henriksen, E.K.

1996-01-01

It may be argued that the population should have sufficient understanding of radiation phenomena to secure individual safety as well as democratic decisions. To attain this, it is necessary for the communicators of radiation information to be familiar with the lay person's perceptions of these phenomena. A questionnaire survey was conducted to examine non-experts' conceptions of radiation phenomena. The survey revealed incomplete understanding of concepts such as radioactive decay, half-life and absorption of radiation and a lack of differentiation between radiation and radioactive material. Many respondents did not distinguish between sources of ionising radiation and other environmental hazards. Nuclear power plants and submarines were the most feared sources of radiation. There are indications that the lay understanding of radiation phenomena and risk is to a large extent formed by mass media and that 'school knowledge' of these phenomena is not applied in situations belonging to the 'real world'. To resolve this problem, new teaching and information procedures are needed. These should take into account the learners' preconceptions and should integrate 'school knowledge' with considerations belonging to the 'real world'. (author)

Personality traits and life satisfaction among online game players.

Science.gov (United States)

Chen, Lily Shui-Lien; Tu, Hill Hung-Jen; Wang, Edward Shih-Tse

2008-04-01

The DFC Intelligence predicts worldwide online game revenues will reach $9.8 billion by 2009, making online gaming a mainstream recreational activity. Understanding online game player personality traits is therefore important. This study researches the relationship between personality traits and life satisfaction in online game players. Taipei, Taiwan, is the study location, with questionnaire surveys conducted in cyber cafe shops. Multiple regression analysis studies the causal relationship between personality traits and life satisfaction in online game players. The result shows that neuroticism has significant negative influence on life satisfaction. Both openness and conscientiousness have significant positive influence on life satisfaction. Finally, implications for leisure practice and further research are discussed.

Enhancing Life Purpose amongst Thai Adolescents

Science.gov (United States)

Balthip, Karnsunaphat; McSherry, Wilfred; Petchruschatachart, Usanee; Piriyakoontorn, Siriwan; Liamputtong, Pranee

2017-01-01

This article describes experiences that enhanced life purpose in 21 Thai adolescents living in Southern Thailand. Thailand is undergoing rapid change from technology, a globalizing economy, and shifting social norms. A phenomenological analysis of in-depth interviews and stories to better understand how Thai youth themselves experience and…

Social Cognitive Predictors of Interest in Research Among Life Sciences Academics

Science.gov (United States)

Sawitri, Dian R.; Nurtjahjanti, Harlina; Prasetyo, Anggun R.

2018-02-01

Research interest is the degree to which an individual is interested in conducting research-related activities. Nowadays, Indonesian higher education academics are expected to be research productive, especially those in life sciences. However, what predicts interest in research among life sciences academics is rarely known. We surveyed 240 life sciences academics (64.6% female, mean age = 31.91 years) from several higher degree institutions in Indonesia, using interest in research, research self-efficacy, and research outcome expectations questionnaires. We used social cognitive career theory which proposes that individual’s interests are the results of the interaction between one’s self-efficacy beliefs and outcome expectations overtime. Structural equation modelling demonstrated that research self-efficacy was directly and indirectly associated with interest in research via research outcome expectations. Understanding the social cognitive predictors of interest in research contributes to an understanding of the associations between research self-efficacy, outcome expectations, and interest in research. Recommendations for life sciences academics, faculties, and higher education institutions are discussed.

Generation time, life history and the substitution rate of neutral mutations.

Science.gov (United States)

Lehtonen, Jussi; Lanfear, Robert

2014-11-01

Our understanding of molecular evolution is hampered by a lack of quantitative predictions about how life-history (LH) traits should correlate with substitution rates. Comparative studies have shown that neutral substitution rates vary substantially between species, and evidence shows that much of this diversity is associated with variation in LH traits. However, while these studies often agree, some unexplained and contradictory results have emerged. Explaining these results is difficult without a clear theoretical understanding of the problem. In this study, we derive predictions for the relationships between LH traits and substitution rates in iteroparous species by using demographic theory to relate commonly measured life-history traits to genetic generation time, and by implication to neutral substitution rates. This provides some surprisingly simple explanations for otherwise confusing patterns, such as the association between fecundity and substitution rates. The same framework can be applied to more complex life histories if full life-tables are available. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

Model systems for life processes on Mars

Science.gov (United States)

Mitz, M. A.

1974-01-01

In the evolution of life forms nonphotosynthetic mechanisms are developed. The question remains whether a total life system could evolve which is not dependent upon photosynthesis. In trying to visualize life on other planets, the photosynthetic process has problems. On Mars, the high intensity of light at the surface is a concern and alternative mechanisms need to be defined and analyzed. In the UV search for alternate mechanisms, several different areas may be identified. These involve activated inorganic compounds in the atmosphere, such as the products of photodissociation of carbon dioxide and the organic material which may be created by natural phenomena. In addition, a life system based on the pressure of the atmospheric constituents, such as carbon dioxide, is a possibility. These considerations may be important for the understanding of evolutionary processes of life on another planet. Model systems which depend on these alternative mechanisms are defined and related to presently planned and future planetary missions.

Career, Migration and the Life CV: A Relational Cultural Analysis

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Schultheiss, Donna E.; Watts, Jane; Sterland, Ljaja; O'Neill, Maggie

2011-01-01

In response to the precarious and disadvantaged position of forced migrants in the United States and the UK, marked by unemployment, under employment and loss of career capital, this paper draws upon a relational cultural paradigm and a life design career model in order to understand migrant work life, shape the career intervention process and…

COMPETENCYTHE FORMATION FOR LIFE

Directory of Open Access Journals (Sweden)

Milagros Mederos-Piñeiro

2016-07-01

Full Text Available The formation of life competences is the result of a quality education that prepares students to meet the challenges of a fast moving world where equality and equal opportunities should constitute premises of education; training them is a challenge teachers to assume new generations contribute actively to a better world. In Cuba are important research on the formation of communication competences and self-regulated learning in primary school. The paper shows the result of an investigation that provides a methodology for the formation of life competences in primary school education, used as an essential pathway research activity. The methodological approach of research has a quantitative approach and an explanatory scope to establish and make sense of understanding the causal relationship between the direction of research activity and training of life competences. Theoretical, empirical and mathematical-statistical, for characterizing the initial state, processing of results and analysis: research methods are used. The application of the methodology for the formation of life competences makes teachers lead the teaching-learning process with a research and transforming teaching concept, where the school is the protagonist of their learning and causes changes in their performances, which are evident in the formed competences related to effective and affective communication; the solution of problems related to life; the use of means in obtaining the knowledge and the expression of a behavior consistent with school and social demands. The effectiveness of the methodology confirms that there is a causal relationship between the direction of research activity by teachers and the formation of life competences in school.

Motor Cognition and Its Role in the Phylogeny and Ontogeny of Action Understanding

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Gallese, Vittorio; Rochat, Magali; Cossu, Giuseppe; Sinigaglia, Corrado

2009-01-01

Social life rests in large part on the capacity to understand the intentions behind the behavior of others. What are the origins of this capacity? How is one to construe its development in ontogenesis? By assuming that action understanding can be explained only in terms of the ability to read the minds of others--that is, to represent mental…

Paternal effects on early life history traits in Northwest Atlantic cod, Gadus morhua

DEFF Research Database (Denmark)

Kroll, M.-M.; Peck, M.A.; Butts, Ian A.E.

2013-01-01

It is important to understand parental effects on early life history of fish as manifested, for example, in individual fitness of offspring. Immediately after fertilization, parental contributions (both genetic and non-genetic) to embryos will affect larval ontogeny, physiology, morphology...... and survival. In marine fish, rates of natural mortality are highest during early life and are negatively correlated with rates of growth and body size. In these early life stages (eggs, larvae, young juveniles) subtle differences in mortality can cause large differences in recruitment and year-class success...... and can serve as important sources of variation during early life stages in fishes. Overall, these findings have implications for furthering the understanding of recruitment variability and can be used to optimize reproductive output for the aquaculture industry. In addition, the data suggests...

Using a Positive Psychology and Family Framework to Understand Mexican American Adolescents' College-Going Beliefs

Science.gov (United States)

Vela, Javier C.; Lenz, A. Stephen; Sparrow, Gregory Scott; Gonzalez, Stacey Lee

2017-01-01

Positive psychology is a useful framework to understand Mexican American adolescents' academic experiences. We used a quantitative, predictive design to explore how presence of meaning in life, search for meaning in life, subjective happiness, hope, and family importance influenced 131 Mexican American adolescents' college-going beliefs. We used…

On the correspondence between CAL and lagged cohort life expectancy

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Michel Guillot

2011-04-01

Full Text Available It has been established that under certain mortality assumptions, the current value of the Cross-sectional Average length of Life (CAL is equal to the life expectancy for the cohort currently reaching its life expectancy. This correspondence is important, because the life expectancy for the cohort currently reaching its life expectancy, or lagged cohort life expectancy (LCLE, has been discussed in the tempo literature as a summary mortality measure of substantive interest. In this paper, we build on previous work by evaluating the extent to which the correspondence holds in actual populations. We also discuss the implications of the CAL-LCLE correspondence (or lack thereof for using CAL as a measure of cohort life expectancy, and for understanding the connection between CAL, LCLE, and underlying period mortality conditions.

A relational understanding of sibling experiences of children with rare life-limiting conditions: findings from a qualitative study.

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Malcolm, Cari; Gibson, Faith; Adams, Sally; Anderson, Gillian; Forbat, Liz

2014-09-01

Mucopolysaccharidoses (MPS) and Batten disease are rare life-limiting conditions (LLCs) characterised by progressive and permanent physical and cognitive decline. The impact of such conditions on families, and notably on siblings, has not yet been described or documented. This paper presents data from a UK-wide study that sought to understand the family experience of supporting a child with the rare degenerative LLCs of MPS and Batten disease. The aim of this paper is to report sibling experiences related to these rare degenerative and progressive conditions, in order to inform the future development of supportive interventions. Eight siblings of children with MPS (n = 7) and Batten Disease (n = 1) participated in semi-structured qualitative interviews. A card sort technique was utilised to support and engage the children. Siblings are clearly impacted emotionally, pragmatically and relationally by the ill health of another child in the family. The data indicate four key themes which demonstrate impacts on siblings: perceptions of the condition and its symptoms, impact on daily life, emotional consequences and ways of coping. Siblings often had considerable knowledge of the condition and took on important roles in symptom management. However, these experiences were in the context of managing relationships within the family (often protecting parents from an awareness of how much they knew) and relationships at school (including distraction from learning and being bullied by peers). The data highlight how sibling experiences are generated through a combination of negative disability discourses and support through peers and family members. The data indicate how these features shift as a consequence of witnessing the advancement of their brother's or sister's condition and the emotional sequelae of disease progression. Exploration of siblings' experiences of living with such rare progressive and degenerative LLCs suggest the focus of interventions to support this

Understanding computer and information technology

International Nuclear Information System (INIS)

Choi, Yun Cheol; Han, Tack Don; Im, Sun Beom

2009-01-01

This book consists of four parts. The first part describes IT technology and information community understanding of computer system, constitution of software system and information system and application of software. The second part is about computer network, information and communication, application and internet service. The third part contains application and multi media, application of mobile computer, ubiquitous computing and ubiquitous environment and computer and digital life. The last part explains information security and ethics of information-oriented society, information industry and IT venture, digital contents technology and industry and the future and development of information-oriented society.

Competences and life management programmes

International Nuclear Information System (INIS)

Brunatti, S.; Bergara, A.; Ranalli, J.; Versaci, R.

2007-01-01

surveillance. In some cases, it may be impossible to rebuild information. As a consequence assumptions may have to be made that cannot be easily substantiated. It is therefore essential that the strategies for plant life management are developed with sufficient clarity to enable the associated human resource strategy or long term Human Resources plan to be developed. This strategy/plan should be reviewed and updated periodically to verify that it is consistent with and supports the nuclear power plant life cycle needs. In this work we analyze the competences of young peoples for working in the Life Management and Life Extension of Nuclear Power Plants Programmes. Competences and skills are understood as including knowing and understanding (theoretical knowledge of an academic field, the capacity to know and understand), knowing how to act (practical and operational application of knowledge to certain situations), knowing how to be (values as an integral element of the way of perceiving and living with others and in a social context). Competences represent a combination of attributes (with respect to knowledge and its application, attitudes, skills and responsibilities) that describe the level or degree to which a person is capable of performing them. In this context, a competence or a set of competences mean that a person puts into play a certain capacity or skill and performs a task, where he/she is able to demonstrate that he/she can do so in a way that allows evaluation of the level of achievement. Competences can be carried out and assessed. It also means that a normally person does not either possess or lack a competence in absolute terms, but commands it to a varying degree, so that competences can be placed on a continuum. The following was taken as a working classification: - Instrumental Competences: Those having an instrumental function. They include: Cognitive abilities, capacity to understand and manipulate ideas and thoughts; Methodological capacities to

Life events and hopelessness depression: The influence of affective experience.

Directory of Open Access Journals (Sweden)

Lihua Zhou

Full Text Available This study explored the association of the affective experience (AE of life events on hopelessness depression (HD. Undergraduates (N = 301 participating in a 12-week prospective study completed measures of HD, cognitive style, and psychological stress. The results indicate AE is an underlying mechanism influencing the longitudinal link between life events and HD. Negative life events with clear negative AE directly promoted the development of HD. Positive life events with clear positive AE directly impeded the development of HD. Neutral life events with mixed AE directly and interacting with negative cognitive style promoted the development of HD. The results should increase understanding of the hopelessness theory of depression, and suggest that neutral life events should be important elements in depression therapy.

Inner and Outer Life at Work. The Roots and Horizon of Psychoanalytically Informed Work Life Research

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Linda Lundgaard Andersen

2012-09-01

Full Text Available The modern labour market has increasingly put the inner working life on the agenda. This stems from a number of societal changes: the knowledge society and its need of personalised competences and work investments in welfare services, the transformation from subject-object relationships to subject-subject relationships and the emergence of the "learning organisations" and reflexive leadership. All of this has been the subject of critical analyses tracing modern work life identities, conflicts, organisational and societal structuration. Against this background the accounts and conceptualisations of work life involving people to people interactions offered by psychodynamic theories and methods take up a pivotal position. Psychoanalytic organisational and work life research explores how work, organisations and individuals are affected by psychic dynamics, the influence of the unconscious in the forms of human development and interaction situated in a societal context. Based on this substantial work I draw upon two influential psychoanalytical positions—the British Tavistock position and German psychoanalytic social psychology in order to situate and identify how to understand the inner and outer life at work—in a generic display of concepts, methods and epistemology. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1203232

Understanding Lay Assessments of Alcohol Use Disorder: Need for Treatment and Associated Stigma.

Science.gov (United States)

Weine, Erienne R; Kim, Nancy S; Lincoln, Alisa K

2016-01-01

Three-quarters of people with an alcohol use disorder in the USA never receive treatment. Our understandings of who receives care are informed by sociological perspectives, theories and models, each of which discuss the role of lay people's understanding of illness. However, comparatively little work has been done to unpack the cognitive processes underlying lay assessment. In the context of the Framework Integrating Normative Influences on Stigma (FINIS), we aim to understand key factors guiding lay people's stigmatizing attitudes, perceptions and assessments of alcohol use disorder behaviors. Lay people read a vignette depicting a male or female adult with a diagnosable alcohol use disorder, along with either a causal life-event explanation for the alcohol use disorder behaviors or no explanation. They then made judgments of the need for treatment, psychological abnormality and the stigma they felt toward the person depicted. Causal life-event explanations decreased lay judgments of the need for treatment, psychological abnormality and stigma. The results suggest that the availability of a causal life-event explanation may have a complex effect on lay judgments, decreasing the likelihood of recommending treatment for alcohol use disorders, yet simultaneously reducing stigmatizing perceptions (and presumably social distance). © The Author 2015. Medical Council on Alcohol and Oxford University Press. All rights reserved.

Toward an Integrative Science of Life-Span Development and Aging

Science.gov (United States)

Piccinin, Andrea M.

2010-01-01

The study of aging demands an integrative life-span developmental framework, involving interdisciplinary collaborations and multiple methodological approaches for understanding how and why individuals change, in both normative and idiosyncratic ways. We highlight and summarize some of the issues encountered when conducting integrative research for understanding aging-related change, including, the integration of results across different levels of analysis; the integration of theory, design, and analysis; and the synthesis of results across studies of aging. We emphasize the necessity of longitudinal designs for understanding development and aging and discuss methodological issues that should be considered for achieving reproducible research on within-person processes. It will be important that current and future studies permit opportunities for quantitative comparison across populations given the extent to which historical shifts and cultural differences influence life-span processes and aging-related outcomes. PMID:20237144

Health-Related Quality of Life in People with Severe Aphasia

Science.gov (United States)

Hilari, Katerina; Byng, Sally

2009-01-01

Background: Health-related quality of life (HRQL) measures are increasingly used to help us understand the impact of disease or disability on a person's life and to measure the effectiveness of interventions. A small number of studies have looked at perceived HRQL in people with mild or moderate aphasia. They report that reduced HRQL is associated…

A STUDY ON EMPLOYEE WORK LIFE BALANCE IN PRECISION INFOMATIC PVT LTD

OpenAIRE

B. Arul Jenifer; S. Vengatesh

2018-01-01

The main goal of this paper is to understand the relationship between work life balance & Employee Engagement. Further this paper highlights contextual factors affecting Employee Engagement and Work Life Balance. This paper is built on relevant literature and recent studies on Work Life Balance Also, the results of the study show inverse relationship between pleasure & work. There has been an increased focus on balancing multiple life roles and managing the boundary between work and family. T...

Food-related life styles in Australia: Testing of the MAPP food-related life style instrument in an Australian context

DEFF Research Database (Denmark)

Reid, Mike; Grunert, Klaus G.; Li, Elton

based assets, and creating a stronger consumer focus. This research employs the Food-Related Life Styles (FRL) instrument developed by Grunert, Brunsø & Bisp, (1993) to determine the validity of the instrument in an Australian context, to build an a better understanding of Australian food consumers......, and to compare Australian consumers with their international counterparts. The research represents the first stage in an on-going process of mapping movements in Australian consumer food-related life styles and linking these to global trends and changes....

'Y' feel me?' How do we understand the person with dementia?

Science.gov (United States)

Hughes, Julian C

2013-05-01

As dementia progresses problems of understanding emerge. Eventually spoken language can be lost. And yet, even into the severer stages of dementia, close carers can often understand the person in a variety of ways. Loss of language is not just a practical problem. It raises philosophical issues too. As Wittgenstein suggested, understanding entails grasping a form of life. Our understanding of agitated, pacing behaviour is similarly based on a unique history, on culture, on context. Hence, a philosophy gestures at the foundations of care. There is the potential to feel the person's meaning, even when it cannot be spoken. This is not simply by means of an alternative to language. The philosophy suggests that our engagement with the person is through and through. Understanding anyone is more like an aesthetic judgement than a cognitive act.

The Right to Life

Directory of Open Access Journals (Sweden)

Varvara Coman

2012-05-01

Full Text Available In the present study, we set ourselves to analyze a subject, which, due to its importance andextreme complexity, generated many discussions and controversies both at national and international level:the right to life. The great evolution of the contemporary society and the progress registered in various fieldsbrought into the attention of the states, international organizations, specialists in the field and public opinionthe pressing problem of interpreting the content and limits of the human fundamental rights and liberties. Weset ourselves to analyze the main international instruments regulating the right to life and to identify thesituations where determining the content of this fundamental right in necessary. Without the intent of acomplete work, we understand, throughout this study, to highline the great importance of the right to liferespecting for the entire humanity.

Constructive Approaches for Understanding the Origin of Self-Replication and Evolution

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Norikazu Ichihashi

2016-07-01

Full Text Available The mystery of the origin of life can be divided into two parts. The first part is the origin of biomolecules: under what physicochemical conditions did biomolecules such as amino acids, nucleotides, and their polymers arise? The second part of the mystery is the origin of life-specific functions such as the replication of genetic information, the reproduction of cellular structures, metabolism, and evolution. These functions require the coordination of many different kinds of biological molecules. A direct strategy to approach the second part of the mystery is the constructive approach, in which life-specific functions are recreated in a test tube from specific biological molecules. Using this approach, we are able to employ design principles to reproduce life-specific functions, and the knowledge gained through the reproduction process provides clues as to their origins. In this mini-review, we introduce recent insights gained using this approach, and propose important future directions for advancing our understanding of the origins of life.

Language Games and Musical Understanding

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Alessandro Arbo

2013-05-01

Full Text Available Wittgenstein has often explored language games that have to do with musical objects of different sizes (phrases, themes, formal sections or entire works. These games can refer to a technical language or to common parlance and correspond to different targets. One of these coincides with the intention to suggest a way of conceiving musical understanding. His model takes the form of the invitation to "hear (something as (something": typically, to hear a musical passage as an introduction or as a conclusion or in a certain tonality. However one may ask to what extent or in what terms (literal or metaphorical these procedures, and usually the intervention of language games, is requested by our common ways of understanding music. This article shows through the use of some examples that aspectual perception inherent to musical understanding does not require language games as a necessary condition (although in many cases the link between them seems very strong, in contradiction with the thesis of an essential linguistic character of music. At a basic level, it seems more appropriate to insist on the notion of a game: to understand music means to enter into the orbit of "music games" which show an autonomous functioning. Language games have, however, an important function when we develop this comprehension in the light of the criteria of judgment that substantiate the manner in which music is incorporated in and operates within specific forms of life.

Content Analysis of Life Exhibitions in Japanese Science Museums and Centres

Science.gov (United States)

Kazama, Tomoko; Ogawa, Masakata

2015-01-01

Life exhibitions in Japanese science museums (SMs) face difficulties in coping with rapid progress in the life sciences owing to certain constraints around the frequency of exhibit renovations, and the Japanese indigenous understanding of the natural world (Shizen) that Japanese visitors unconsciously bring with them. To what extent do current…

Constructs of the Work/Life Interface and Their Importance to HRD

Science.gov (United States)

McMillan, Heather S.; Morris, Michael Lane; Atchley, E. Kate

2008-01-01

The purpose of this paper is to identify construct definitions and measurement tools for the work/life interface concepts: balance, conflict and facilitation. An understanding of these concepts is critical to HRD (human resource development) professionals because interventions designed to counter work/life interface issues can not be created, and…

Sensing sense and mobility at the end of the life course

DEFF Research Database (Denmark)

Blaakilde, Anne Leonora

2015-01-01

is struggling with memory loss, which is impeding his life as a retired migrant. The method of embodied interaction is used in order to sense and understand his sensing of the process of mental decline. This is exemplified by three analytic perspectives: touch, embodied map, and materialised mind....... The methodology presented contributes with a focus on understanding based on sensouos theory which implies embodied interaction and an active co-construction of meaning by ethnographer as well as by reader. This chapter's discussion of a methodology that values the senses adds richness to research on the life...

Influence of heat treatment on the microstructure and mechanical properties of Alloy 718 base metal and weldments

International Nuclear Information System (INIS)

Mills, W.J.

1979-06-01

Effect of heat treatment on the metallurgical structure and tensile properties of three heats of Alloy 718 base metal and an Alloy 718 GTA weldment were characterized. Heat treatments employed were the conventional (ASTM A637) precipitation treatment and a modified precipitation treatment designed to improve the toughness of the weldments. The GTA weldments were characterized in the as-welded condition. Light microscopy, thin foil, and surface replica electron microscopy revealed that the microstructure of this superalloy was sensitive to heat treatment and heat-to-heat variations. The modified aging treatment resulted in a larger grain size and a more homogeneous microstructure than the conventional treatments. The morphology of the primary strengthening γ phase was found to be finer and more closely spaced in the conventionally treated condition. Room and elevated temperature tensile testing revealed that the strength of the conventionally treated alloy was generally superior to that of the modified material. The conventional aging treatment resulted in greater heat-to-heat variations in tensile properties. This behavior was correlated with variations in the microstructure resulting from the precipitation heat treatments. The precipitate morphology of the GTA weldments was sensitive to heat treatment. The Laves phase was present in the interdendritic regions of both heat-treated welds. The modified aging treatment reduced the amount of Laves phase present in the weld zone. Room and elevated temperature tensile properties of the precipitation hardened weldments were relatively insensitive to heat treatment, suggesting that reduction in Laves phase from the weld zone had essentially no effect on tensile properties. As-welded GTA weldments exhibited lower strength levels and higher ductility values than heat-treated welds

Life on the Number Line: Routes to Understanding Fraction Magnitude for Students With Difficulties Learning Mathematics.

Science.gov (United States)

Gersten, Russell; Schumacher, Robin F; Jordan, Nancy C

Magnitude understanding is critical for students to develop a deep understanding of fractions and more advanced mathematics curriculum. The research reports in this special issue underscore magnitude understanding for fractions and emphasize number lines as both an assessment and an instructional tool. In this commentary, we discuss how number lines broaden the concept of fractions for students who are tied to the more general part-whole representations of area models. We also discuss how number lines, compared to other representations, are a superior and more mathematically correct way to explain fraction concepts.

Understanding institutional stakeholders’ perspectives on multidrug-resistant bacterial organism at the end of life: a qualitative study

Directory of Open Access Journals (Sweden)

Heckel M

2017-10-01

Full Text Available Maria Heckel,1 Franziska A Herbst,2 Thomas Adelhardt,3 Johanna M Tiedtke,4 Alexander Sturm,5 Stephanie Stiel,2 Christoph Ostgathe1 1Department of Palliative Medicine, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU, Universitätsklinikum Erlangen, Bavaria, Germany; 2Institute for General Practice, Hannover Medical School, Hannover, Germany; 3Division of Health Management, School of Business and Economics, Institute of Management (IFM, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU, Bavaria, Germany; 4Institute of Psychogerontology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU, Bavaria, Germany; 5Department of General Internal and Geriatric Medicine, Institute for Biomedicine of Aging, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU, Hospital of the Order of St John of God Regensburg, Bavaria, Germany Background: Information lacks about institutional stakeholders’ perspectives on management approaches of multidrug-resistant bacterial organism in end-of-life situations. The term “institutional stakeholder” includes persons in leading positions with responsibility in hospitals’ multidrug-resistant bacterial organism management. They have great influence on how strategies on multidrug-resistant bacterial organism management approaches in institutions of the public health system are designed. This study targeted institutional stakeholders’ individual perspectives on multidrug-resistant bacterial organism colonization or infection and isolation measures at the end of life. Methods: Between March and December 2014, institutional stakeholders of two study centers, a German palliative care unit and a geriatric ward, were queried in semistructured interviews. Interviews were audiotaped, transcribed verbatim, and analyzed qualitatively with the aid of the software MAXQDA for qualitative data analysis using principles of Grounded Theory. In addition, two external

Materialism and life satisfaction: the role of religion.

Science.gov (United States)

Rakrachakarn, Varapa; Moschis, George P; Ong, Fon Sim; Shannon, Randall

2015-04-01

This study examines the role of religion and religiosity in the relationship between materialism and life satisfaction. The findings suggests that religion may be a key factor in understanding differences in findings of previous studies regarding the inverserelationship found in the vast majority of previous studies. Based on a large-scale study in Malaysia—a country comprised of several religious subcultures (mainly Muslims, Buddhists, and Hindus), the findings suggest that the influence of religiosity on materialism and life satisfaction is stronger among Malays than among Chinese and Indians, and life satisfaction partially mediates the relationship between religiosity and materialism. The paper discusses implications for theory development and further research.

Pathways to Well-Being in Later Life: Socioeconomic and Health Determinants Across the Life Course of Australian Baby Boomers.

Science.gov (United States)

Kendig, Hal; Loh, Vanessa; O'Loughlin, Kate; Byles, Julie; Nazroo, James Y

2016-01-01

In many countries like Australia and the United States, baby boomers are referred to as the 'lucky cohort', yet there has been little research on the origins and extent of inequalities within this cohort. This study uses path analysis to investigate direct and indirect effects of childhood and adult socioeconomic status and health on two subjective well-being measures: quality of life and life satisfaction. Retrospective life course data were obtained for 1,261 people aged 60 to 64 in the 2011-12 Life Histories and Health survey, a sub-study of the Australian 45 and Up Study. Supporting an accumulation model, the number of negative childhood and adult exposures were inversely related to both types of well-being. Consistent with a critical period model, childhood exposures had small but significant effects on subjective well-being and were relatively more important for quality of life than for life satisfaction. However, these childhood effects were largely indirect and significantly mediated by more proximal adult exposures, providing support for a pathway model. A key implication of this research is that the critical period for later life well-being is significant in adulthood rather than childhood, suggesting that there may be key opportunities for improving individuals' later life well-being far beyond the early, formative years. This research highlights the importance of understanding how earlier life exposures impact experiences in later life, and investing in health and socioeconomic opportunities to reduce inequalities across all stages of life.

Developing mathematical models to predict tensile properties of pulsed current gas tungsten arc welded Ti-6Al-4V alloy

International Nuclear Information System (INIS)

Balasubramanian, M.; Jayabalan, V.; Balasubramanian, V.

2008-01-01

Titanium (Ti-6Al-4V) alloy has gathered wide acceptance in the fabrication of light weight structures requiring a high strength-to-weight ratio, such as transportable bridge girders, military vehicles, road tankers and railway transport systems. The preferred welding process of titanium alloy is frequently gas tungsten arc (GTA) welding due to its comparatively easier applicability and better economy. In the case of single pass GTA welding of thinner section of this alloy, the pulsed current has been found beneficial due to its advantages over the conventional continuous current process. Many considerations come into the picture and one need to carefully balance various pulse current parameters to arrive at an optimum combination. Hence, in this investigation an attempt has been made to develop mathematical models to predict tensile properties of pulsed current GTA welded titanium alloy weldments. Four factors, five level, central composite, rotatable design matrix is used to optimise the required number of experiments. The mathematical models have been developed by response surface method (RSM). The adequacy of the models has been checked by ANOVA technique. By using the developed mathematical models, the tensile properties of the joints can be predicted with 99% confidence level

Developing mathematical models to predict tensile properties of pulsed current gas tungsten arc welded Ti-6Al-4V alloy

Energy Technology Data Exchange (ETDEWEB)

Balasubramanian, M. [Department of Production Engineering, Sathyabama University, Old Mamallapuram Road, Chennai 600 119 (India)], E-mail: manianmb@rediffmail.com; Jayabalan, V. [Department of Manufacturing Engineering, Anna University, Guindy, Chennai 600 025 (India)], E-mail: jbalan@annauniv.edu; Balasubramanian, V. [Department of Manufacturing Engineering, Annamalai University, Annamalai Nagar 608 002 (India)], E-mail: visvabalu@yahoo.com

2008-07-01

Titanium (Ti-6Al-4V) alloy has gathered wide acceptance in the fabrication of light weight structures requiring a high strength-to-weight ratio, such as transportable bridge girders, military vehicles, road tankers and railway transport systems. The preferred welding process of titanium alloy is frequently gas tungsten arc (GTA) welding due to its comparatively easier applicability and better economy. In the case of single pass GTA welding of thinner section of this alloy, the pulsed current has been found beneficial due to its advantages over the conventional continuous current process. Many considerations come into the picture and one need to carefully balance various pulse current parameters to arrive at an optimum combination. Hence, in this investigation an attempt has been made to develop mathematical models to predict tensile properties of pulsed current GTA welded titanium alloy weldments. Four factors, five level, central composite, rotatable design matrix is used to optimise the required number of experiments. The mathematical models have been developed by response surface method (RSM). The adequacy of the models has been checked by ANOVA technique. By using the developed mathematical models, the tensile properties of the joints can be predicted with 99% confidence level.

Understanding ageing: Biomedical and bioengineering approaches, the immunologic view

Directory of Open Access Journals (Sweden)

Vasto Sonya

2008-09-01

Full Text Available Abstract During the past century, humans have gained more years of average life expectancy than in the last 10,000 years; we are now living in a rapidly ageing world. The sharp rise in life expectancy, coupled to a steady decline in birth rates in all developed countries, has led to an unprecedented demographic revolution characterized by an explosive growth in the number and proportion of older people. Ageing is a complex process that negatively impacts the development of the immune system and its ability to function. Progressive changes in the T and B cell systems over the life span have a major impact on the capacity to respond to immune challenge. These cumulative age-associated changes in immune competence are termed Immunosenescence: some immunological parameters are commonly notably reduced in the elderly and, reciprocally good function is tightly correlated to health status. Hence, a better understanding of Immunosenescence and the development of new strategies to counteract it are essential for improving the quality of life of the elderly population.

Translating Missions in James Worral’s game “Grand Theft Auto’s Missions”

Directory of Open Access Journals (Sweden)

Zelika Rahmi

2018-02-01

Full Text Available The objectives of the study was to know the difficult words encountered by the gamers and to know their strategies in translating this unknown word. The researcher used interview as the instrument to collect the material needed for this particular study. It is found that unknown word combined with certain feeling such as dissappoinment creates retention. So, this particular study showed eventhough these students have low capacity in understanding words in English but in GTA game, they were still willing to play. From their willingness it could increase their motivation to translating the word in English. So, the game is a very effective way to building vocabullary skill.

Expanded Understanding of IS/IT Related Challenges in Mergers and Acquisitions

DEFF Research Database (Denmark)

Toppenberg, Gustav

2015-01-01

Organizational Mergers and Acquisitions (M&As) occur at an increasingly frequent pace in today’s business life. Paralleling this development, M&As has increasingly attracted attention from the Information Systems (IS) domain. This emerging line of research has started form an understanding...

Revised analysis of the Transition Joint Life Test

Energy Technology Data Exchange (ETDEWEB)

Sartory, W K

1984-07-01

The Transition Joint Life Test was performed by General Electric and the Energy Technology Engineering Center and was analyzed earlier by General Electric. Because of later developments in analysis techniques and in our understanding of the stress behavior near a dissimilar metal weldment, agreement was reached between General Electric and Oak Ridge National Laboratory`s High-Temperature Structural Design program that a more up-to-date analysis was needed. This report presents results of a new analysis incorporating modified mechanical properties, revised constitutive equations, and a more refined finite element grid. The structural life prediction of the present report is quite conservative (approximately 3 cycles of predicted life compared to 12 to 25 cycles of measured life), whereas the earlier General Electric analysis was underconservative by a similar factor.

"Life history space": a multivariate analysis of life history variation in extant and extinct Malagasy lemurs.

Science.gov (United States)

Catlett, Kierstin K; Schwartz, Gary T; Godfrey, Laurie R; Jungers, William L

2010-07-01

Studies of primate life history variation are constrained by the fact that all large-bodied extant primates are haplorhines. However, large-bodied strepsirrhines recently existed. If we can extract life history information from their skeletons, these species can contribute to our understanding of primate life history variation. This is particularly important in light of new critiques of the classic "fast-slow continuum" as a descriptor of variation in life history profiles across mammals in general. We use established dental histological methods to estimate gestation length and age at weaning for five extinct lemur species. On the basis of these estimates, we reconstruct minimum interbirth intervals and maximum reproductive rates. We utilize principal components analysis to create a multivariate "life history space" that captures the relationships among reproductive parameters and brain and body size in extinct and extant lemurs. Our data show that, whereas large-bodied extinct lemurs can be described as "slow" in some fashion, they also varied greatly in their life history profiles. Those with relatively large brains also weaned their offspring late and had long interbirth intervals. These were not the largest of extinct lemurs. Thus, we distinguish size-related life history variation from variation that linked more strongly to ecological factors. Because all lemur species larger than 10 kg, regardless of life history profile, succumbed to extinction after humans arrived in Madagascar, we argue that large body size increased the probability of extinction independently of reproductive rate. We also provide some evidence that, among lemurs, brain size predicts reproductive rate better than body size. (c) 2010 Wiley-Liss, Inc.

New technology in everyday life - social processes and environmental impact

DEFF Research Database (Denmark)

Røpke, Inge

2001-01-01

In the environmental debate it is increasingly acknowledged that our way of life has profound environmental consequences. Therefore, it becomes ever more important to focus on and to understand how everyday life is formed and how it changes over time. Changing technology constitutes an important...... of several of the dynamic forces behind consumption and thus contribute to the growing quantities of consumption, which counteract the environmental improvements. Secondly, because some of the technological changes are integrated with the processes which change everyday life more profoundly and thus...

Reproductive Life Planning: Raising the Questions.

Science.gov (United States)

Morse, Jessica E; Moos, Merry-K

2018-04-01

Introduction Unintended pregnancy has been a concerning public health problem for decades. As we begin to understand the complexities of pregnancy intention and how women experience these pregnancies, reproductive life planning offers a paradigm shift. Methods Reproductive life planning is a patient-centered approach that places a patient's reproductive preferences-whether concrete or ambivalent-at the forefront of her clinical care. Results This process grants women and men the opportunity to consider how reproduction fits within the context of their broader lives. Within a clinical encounter, reproductive life planning allows counseling and care to be tailored to patient preferences. Discussion Although there is great potential for positive public health impacts in unintended pregnancy, contraceptive use and improved preconception health, the true benefit lies within reinforcing reproductive empowerment. Despite recommendations for universal adoption, many questions remain regarding implementation, equity and outcomes.

Mediation effects of medication information processing and adherence on association between health literacy and quality of life.

Science.gov (United States)

Song, Sunmi; Lee, Seung-Mi; Jang, Sunmee; Lee, Yoon Jin; Kim, Na-Hyun; Sohn, Hye-Ryoung; Suh, Dong-Churl

2017-09-16

To examine whether medication related information processing defined as reading of over-the-counter drug labels, understanding prescription instructions, and information seeking-and medication adherence account for the association between health literacy and quality of life, and whether these associations may be moderated by age and gender. A sample of 305 adults in South Korea was recruited through a proportional quota sampling to take part in a cross-sectional survey on health literacy, medication-related information processing, medication adherence, and quality of life. Descriptive statistics and structural equation modeling (SEM) were performed. Two mediation pathways linking health literacy with quality of life were found. First, health literacy was positively associated with reading drug labels, which was subsequently linked to medication adherence and quality of life. Second, health literacy was positively associated with accurate understanding of prescription instructions, which was associated with quality of life. Age moderation was found, as the mediation by reading drug labels was significant only among young adults whereas the mediation by understanding of medication instruction was only among older adults. Reading drug labels and understanding prescription instructions explained the pathways by which health literacy affects medication adherence and quality of life. The results suggest that training skills for processing medication information can be effective to enhance the health of those with limited health literacy.

Teaching Teaching & Understanding Understanding

DEFF Research Database (Denmark)

2006-01-01

"Teaching Teaching & Understanding Understanding" is a 19-minute award-winning short-film about teaching at university and higher-level educational institutions. It is based on the "Constructive Alignment" theory developed by Prof. John Biggs. The film delivers a foundation for understanding what...

Understanding the Determinants of Health-Related Quality of Life in Rheumatoid Arthritis-Associated Interstitial Lung Disease

Science.gov (United States)

Natalini, Jake G.; Swigris, Jeff J.; Morisset, Julie; Elicker, Brett M.; Jones, Kirk D.; Fischer, Aryeh; Collard, Harold R.; Lee, Joyce S.

2017-01-01

Rationale Health-related quality of life (HRQL) is impaired among patients with interstitial lung disease (ILD). Little is understood about HRQL in specific subtypes of ILD. Objectives The aim of this study was to characterize and identify clinical determinants of HRQL among patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and compare them to patients with idiopathic pulmonary fibrosis (IPF). Methods We identified patients with a diagnosis of RA-ILD and IPF from an ongoing longitudinal cohort of ILD patients. HRQL was measured at their baseline visit using the Short Form Health Survey (SF-36), versions 1 and 2. Regression models were used to characterize and understand the relationship between selected baseline clinical covariates, the physical component score (PCS) and mental component score (MCS) of the SF-36. Measurements and Main Results RA-ILD patients (n=50) were more likely to be younger and female compared to IPF patients (n=50). After controlling for age and pulmonary function, RA-ILD patients had a lower HRQL compared to IPF patients, as measured by the PCS (P=0.03), with significant differences in two of four PCS domains – bodily pain (P<0.01) and general health (P=0.01). Clinical covariates most strongly associated with a lower PCS in RA-ILD patients compared to IPF patients were the presence of joint pain or stiffness and dyspnea severity (P<0.01). Mental and emotional health, as measured by the MCS, was similar between RA-ILD and IPF patients. Conclusion The physical components of HRQL appear worse in RA-ILD patients compared to IPF patients as measured by the PCS of the SF-36. Differences in the PCS of the SF-36 can be explained in part by dyspnea severity and joint symptoms among patients with RA-ILD. PMID:28502413

Supporting Parents with Two Essential Understandings: Attachment and Brain Development.

Science.gov (United States)

Berger, Eugenia Hepworth

1999-01-01

Readiness to learn is a constant state. Two critical aspects of early childhood provide parents sufficient understanding of their child's development: attachment and brain development. Children develop attachments to caregivers but need consistent parental care and love. Human brains continue to quickly grow during the first two years of life.…

Optimizing Introductory Physics for the Life Sciences: Placing Physics in Biological Context

Science.gov (United States)

Crouch, Catherine

2014-03-01

Physics is a critical foundation for today's life sciences and medicine. However, the physics content and ways of thinking identified by life scientists as most important for their fields are often not taught, or underemphasized, in traditional introductory physics courses. Furthermore, such courses rarely give students practice using physics to understand living systems in a substantial way. Consequently, students are unlikely to recognize the value of physics to their chosen fields, or to develop facility in applying physics to biological systems. At Swarthmore, as at several other institutions engaged in reforming this course, we have reorganized the introductory course for life science students around touchstone biological examples, in which fundamental physics contributes significantly to understanding biological phenomena or research techniques, in order to make explicit the value of physics to the life sciences. We have also focused on the physics topics and approaches most relevant to biology while seeking to develop rigorous qualitative reasoning and quantitative problem solving skills, using established pedagogical best practices. Each unit is motivated by and culminates with students analyzing one or more touchstone examples. For example, in the second semester we emphasize electric potential and potential difference more than electric field, and start from students' typically superficial understanding of the cell membrane potential and of electrical interactions in biochemistry to help them develop a more sophisticated understanding of electric forces, field, and potential, including in the salt water environment of life. Other second semester touchstones include optics of vision and microscopes, circuit models for neural signaling, and magnetotactic bacteria. When possible, we have adapted existing research-based curricular materials to support these examples. This talk will describe the design and development process for this course, give examples of

Kant on anatomy and the status of the life sciences.

Science.gov (United States)

Olson, Michael J

2016-08-01

This paper contributes to recent interest in Kant's engagement with the life sciences by focusing on one corner of those sciences that has received comparatively little attention: physical and comparative anatomy. By attending to remarks spread across Kant's writings, we gain some insight into Kant's understanding of the disciplinary limitations but also the methodological sophistication of the study of anatomy and physiology. Insofar as Kant highlights anatomy as a paradigmatic science guided by the principle of teleology in the Critique of the Power of Judgment, a more careful study of Kant's discussions of anatomy promises to illuminate some of the obscurities of that text and of his understanding of the life sciences more generally. In the end, it is argued, Kant's ambivalence with regard to anatomy gives way to a pessimistic conclusion about the possibility that anatomy, natural history, and, by extension, the life sciences more generally might one day become true natural sciences. Copyright © 2016 Elsevier Ltd. All rights reserved.

The Family Life Cycle and Critical Transitions: Utilizing Cinematherapy to Facilitate Understanding and Increase Communication

Science.gov (United States)

Ballard, Mary B.

2012-01-01

Transitioning successfully from one stage of development to the next in the family life cycle requires the accomplishment of certain developmental tasks. Couples and families who fail to accomplish these tasks often become "stuck" and unable to move forward. This impasse frequently leads to heightened stress reactions and crippled channels of…

Work/Life Balance Issues for Female Physicians and Implications for Medical Education

Science.gov (United States)

Corder, Paige Frances

2016-01-01

Work/life balance issues exist for all people who navigate both professional and personal responsibilities, regardless of profession, gender, marital status, or number of children. This research sought to better understand the specific work/life balance challenges faced by female physicians and how medical education can better prepare future…

Qualitative Exploration of Acculturation and Life-Span Issues of Elderly Asian Americans

Science.gov (United States)

Lee, Jee Hyang; Heo, Nanseol; Lu, Junfei; Portman, Tarrell Awe Agahe

2013-01-01

Awareness of aging issues across diverse populations begins the journey toward counselors becoming culturally competent across client life spans. Understanding the life-span experiences of cultural groups is important for helping professionals. The purpose of this research was to gain insight into the qualitative experiences of Asian American…

Moral landscapes and everyday life in families with Huntington´s Disease

DEFF Research Database (Denmark)

Huniche, Lotte

2011-01-01

This article is concerned with understanding moral aspects of everyday life in families with Huntington’s Disease (HD). It draws on findings from an empirical research project in Denmark in 1998e2002 involving multi-sited ethnography to argue that medical genetics provides a particular framework...... for conducting life in an HD family. A framework that implies that being informed and making use of genetic services expresses greater moral responsibility than conducting life without drawing on these resources. The moral imperative of engagement in medical genetics is challenged here by two pieces...... nor the imagined solutions of medical genetics are as unproblematic and straightforward as might be thought. To assist our understanding of the moral aspects of living with severe familial disease, the ethnographic analysis is aligned with bioethical reflections that place the concrete concerns...

Enhancing the Empathic Connection: Using Action Methods to Understand Conflicts in End-of-Life Care

Directory of Open Access Journals (Sweden)

Silvia Tanzi

2014-05-01

Full Text Available Empathy is a core feature of patient-centered care. It enables practitioners to better understand the patient and family concerns that are key to patient and family satisfaction, prevention of anxiety and depression, and provider empowerment. Current methods of teaching communication skills do not specifically focus on enhancing the ability to “stand in the patient's shoes” as a way of connecting with the patient and/or family experience and understanding feelings that may be a source of conflict with providers. In this paper, we present a model for deepening empathic understanding based upon action methods (role-reversal and doubling derived from psychodrama and sociodrama. We describe these techniques and illustrate how they can be used to identify hidden emotions and attitudes and reveal that which the patient and family member may be thinking or feeling but be afraid to say. Finally, we present data showing that these methods were valuable to participants in enhancing their professional experience and skills.

Enhancing the Empathic Connection: Using Action Methods to Understand Conflicts in End-of-Life Care

Science.gov (United States)

Tanzi, Silvia; Biasco, Guido; Baile, Walter F.

2014-01-01

Empathy is a core feature of patient-centered care. It enables practitioners to better understand the patient and family concerns that are key to patient and family satisfaction, prevention of anxiety and depression, and provider empowerment. Current methods of teaching communication skills do not specifically focus on enhancing the ability to “stand in the patient's shoes” as a way of connecting with the patient and/or family experience and understanding feelings that may be a source of conflict with providers. In this paper, we present a model for deepening empathic understanding based upon action methods (role-reversal and doubling) derived from psychodrama and sociodrama. We describe these techniques and illustrate how they can be used to identify hidden emotions and attitudes and reveal that which the patient and family member may be thinking or feeling but be afraid to say. Finally, we present data showing that these methods were valuable to participants in enhancing their professional experience and skills. PMID:28725796

Enhancing the Empathic Connection: Using Action Methods to Understand Conflicts in End-of-Life Care.

Science.gov (United States)

Tanzi, Silvia; Biasco, Guido; Baile, Walter F

2014-05-01

Empathy is a core feature of patient-centered care. It enables practitioners to better understand the patient and family concerns that are key to patient and family satisfaction, prevention of anxiety and depression, and provider empowerment. Current methods of teaching communication skills do not specifically focus on enhancing the ability to "stand in the patient's shoes" as a way of connecting with the patient and/or family experience and understanding feelings that may be a source of conflict with providers. In this paper, we present a model for deepening empathic understanding based upon action methods (role-reversal and doubling) derived from psychodrama and sociodrama. We describe these techniques and illustrate how they can be used to identify hidden emotions and attitudes and reveal that which the patient and family member may be thinking or feeling but be afraid to say. Finally, we present data showing that these methods were valuable to participants in enhancing their professional experience and skills.

Debkiss or the quest for the simplest generic model of animal life history.

NARCIS (Netherlands)

Jager, T.; Martin, B.T.; Zimmer, E.I.

2013-01-01

Understanding the life cycle of individual animals, and how it responds to stress, requires a model that causally links life-history traits (feeding, growth, development and reproduction). Dynamic Energy Budget (DEB) theory offers a powerful and formalised framework for building process-based models

Nurturing the Respectful Community through Practical Life

Science.gov (United States)

Bettmann, Joen

2015-01-01

Joen Bettmann's depiction of practical life exercises as character-building reveals how caring, careful, and independent work leads to higher self-esteem, more concern for others, better understanding for academic learning, and a self-nurturing, respectful classroom community. Particular aspects of movement and silence exercises bring out what…

Preservice Science Teachers’ Levels of Associating The Concept of Gas Pressure with Everyday Life

Directory of Open Access Journals (Sweden)

Aybüke Pabuçcu

2016-10-01

Full Text Available Through this research, it was aimed to investigate how pre-service science teachers’ use their knowledge about the concept of gas pressure in explaining some examples from everyday life. The research was carried out with 33 freshmen pre-service science teachers. The data in the research were collected through five formative assessment probes. The students were asked to work in small groups to complete the questions. Groups’ discussions were recorded. Groups’ written responses were classified in five different categories: sound understanding, partial understanding, specific misconception, no understanding, and no response. Data under these categories were given as percentages in a table. The sum of students’ responses in sound understanding and partial understanding are in the range of 37.5% and 62.5%. Results revealed that students had difficulty in understanding the gases concepts and associating these concepts with everyday life events. Moreover, many misconceptions and misuse of the ideal gas equation were determined in the students’ explanations.

Life history and bioeconomy of the house mouse.

Science.gov (United States)

Berry, R J; Bronson, F H

1992-11-01

1. More is known about the western European house mouse, Mus (musculus) domesticus than any other non-human mammal. If laboratory and field information is combined, an extremely valuable understanding of the species' bioeconomy could be obtained. 2. The seven stages of mouse life-history are surveyed (up to birth, nest life, sex life, social structure, population statics and stability, senescence, and death), and the interactions between the changing phenotype and the environment are described. 3. These interactions can be used to build up a model of the opportunities and compromises which result in the fitness of individual mice. It is not yet possible to quantify such a model, but this should in principle be achievable.

Shelf life stability of lactobacilli encapsulated in raspberry powder: insights into non-dairy probiotics.

Science.gov (United States)

Anekella, Kartheek; Orsat, Valérie

2014-06-01

Study the shelf-life quality changes in raspberry juice with encapsulated lactobacilli (Lactobacillus rhamnosus NRRL B-4495 and Lactobacillus acidophilus NRRL B-442) obtained by spray drying and understand the various factors involved. Raspberry powder was obtained from spray drying lactobacilli and raspberry juice with maltodextrin as an additive. Shelf life of the powder was analyzed over a period of 30 d. Acid and bile tolerance and antibiotic resistance was compared before and after spray drying. Water activity, survival, and scanning electron microscope images were also measured during the shelf life. A combination of processing conditions: inlet temperature (°C), maltodextrin to juice solids ratio and inlet feed rate (ml/min) during spray drying had a significant role on the survival of lactobacilli during shelf life. Refrigerated storage provided a higher shelf-life stability with regards to CFU/g (as high as 84% on day 0 and 98% retention by the end of 30 d) compared to room temperature storage. Probiotic properties during shelf life are affected by the processing conditions and encapsulated food matrix. Thus, understanding these aspects in vitro during shelf life gives us a brief insight into the future of non-dairy probiotics.

Primates and the Evolution of Long-Slow Life Histories

Science.gov (United States)

Jones, James Holland

2011-01-01

Summary Primates are characterized by relatively late ages at first reproduction, long lives and low fertility. Together, these traits define a life-history of reduced reproductive effort. Understanding the optimal allocation of reproductive effort, and specifically reduced reproductive effort, has been one of the key problems motivating the development of life history theory. Because of their unusual constellation of life-history traits, primates play an important role in the continued development of life history theory. In this review, I present the evidence for the reduced reproductive effort life histories of primates and discuss the ways that such life-history tactics are understood in contemporary theory. Such tactics are particularly consistent with the predictions of stochastic demographic models, suggesting a key role for environmental variability in the evolution of primate life histories. The tendency for primates to specialize in high-quality, high-variability food items may make them particularly susceptible to environmental variability and explain their low reproductive-effort tactics. I discuss recent applications of life history theory to human evolution and emphasize the continuity between models used to explain peculiarities of human reproduction and senescence with the long, slow life histories of primates more generally. PMID:21959161

Cosmic Biology How Life Could Evolve on Other Worlds

CERN Document Server

Irwin, Louis Neil

2011-01-01

It is very unlikely that little green humanoids are living on Mars. But what are the possible life forms that might exist in our Solar System and how might they have evolved? This uniquely authoritative and imaginative book on the possibilties for alien life addresses the intrinsic interest that we have about life on other worlds - reinforcing some of our assumptions and reshaping others. It introduces new possibilties that will enlarge our understanding of the issue overall, in particular the enormous range of environments and planetary conditions within which life might evolve. Cosmic Biology -discusses a broad range of possible environments where alien life might have evolved; -explains why carbon-based, water-borne life is more likely that its alternatives, but is not the only possiblity; -applies the principles of planetary science and modern biology to evolutionary scenarios on other worlds; -looks at the future fates of living systems, including those on Earth.

Learning in Life History - psycho-societal interpretation of biographies

DEFF Research Database (Denmark)

Olesen, Henning Salling

2008-01-01

Taking its point of departure from some critical remarks about some of the most important recent theorizing of learning, this article presents an alternative framework for theorizing learning as a subjective process in a social and societal context, based on life history research. The key concepts...... of subjectivity and experience, derived from European critical theory, are briefly introduced with respect to their intellectual background. Based on examples from the author’s research into the professional learning, the article outlines the implications of these concepts in relation to an understanding...... of emotional aspects of learning in everyday life and to an understanding of knowledge. The pivotal role of language use and language socialisation is explained in brief, and a psychodynamic complement to a language game concept of language use is developed....

Cultures of Work-Life Balance in Higher Education: A Case of Fragmentation

Science.gov (United States)

Lester, Jaime

2015-01-01

In response to demographic shifts, colleges and universities implemented new policies, adopted new practices, and created professional development opportunities to gain support for work-life balance. Research on work-life balance reveals gender disparities, lack of policy usage, and a lack of cultural change with little understanding of the ways…

Habitat Fragmentation Drives Plant Community Assembly Processes across Life Stages

Science.gov (United States)

Hu, Guang; Feeley, Kenneth J.; Yu, Mingjian

2016-01-01

Habitat fragmentation is one of the principal causes of biodiversity loss and hence understanding its impacts on community assembly and disassembly is an important topic in ecology. We studied the relationships between fragmentation and community assembly processes in the land-bridge island system of Thousand Island Lake in East China. We focused on the changes in species diversity and phylogenetic diversity that occurred between life stages of woody plants growing on these islands. The observed diversities were compared with the expected diversities from random null models to characterize assembly processes. Regression tree analysis was used to illustrate the relationships between island attributes and community assembly processes. We found that different assembly processes predominate in the seedlings-to-saplings life-stage transition (SS) vs. the saplings-to-trees transition (ST). Island area was the main attribute driving the assembly process in SS. In ST, island isolation was more important. Within a fragmented landscape, the factors driving community assembly processes were found to differ between life stage transitions. Environmental filtering had a strong effect on the seedlings-to-saplings life-stage transition. Habitat isolation and dispersal limitation influenced all plant life stages, but had a weaker effect on communities than area. These findings add to our understanding of the processes driving community assembly and species coexistence in the context of pervasive and widespread habitat loss and fragmentation. PMID:27427960

Solar activity and life. A review

International Nuclear Information System (INIS)

Messerotti, M.; Chela-Flores, J.

2007-09-01

Recent claims advocate a downward revision of the solar oxygen abundance. This is a reflection of what may be called a 'solar crisis' whereby we mean that previous consensus in our understanding of our nearest star was unfounded. The implications for solar physics, and chemistry, are obvious and much research in the near future will give us a much clearer understanding of the Sun. We wish to review and update recent work concerning the frontier between Space Weather (SpW) and Astrobiology. We argue that the present robust programs of various space agencies reinforce our hope for a better understanding of the bases of Astrobiology. Eventually with a more realistic model of the Sun, more reliable discussions of all the factors influencing the origin of life on Earth will be possible. (author)

Promoting Prospective Elementary Teachers' Learning to Use Formative Assessment for Life Science Instruction

Science.gov (United States)

Sabel, Jaime L.; Forbes, Cory T.; Zangori, Laura

2015-01-01

To support elementary students' learning of core, standards-based life science concepts highlighted in the "Next Generation Science Standards," prospective elementary teachers should develop an understanding of life science concepts and learn to apply their content knowledge in instructional practice to craft elementary science learning…

The life trajectories modality of oral history

Directory of Open Access Journals (Sweden)

Rita de Cássia Gonçalves

2007-05-01

Full Text Available This article seeks to explore the potential of qualitative research. It presents the life trajectory modality of the oral history method, to discuss the possibility of its utilization in scientific research in the Social Work profession. The epistemological foundations of oral history are discussed to establish its scientific character. The life trajectories modality is presented as a historic and social construction that utilizes different interview techniques to give voice to previously invisible subjects, indicating the principal phases of the methodological procedures used in this approach. The conclusions highlight the importance of the construction of this model and its projection as a research proposal that implies a process of understanding and analyzing the social universes that are contextualized and interconnected, considering the realities of the life trajectories of the subjects studied.

Forecasting the Effects of Obesity and Smoking on U.S. Life Expectancy

OpenAIRE

Stewart, Susan T.; Cutler, David M.; Rosen, Allison B.

2009-01-01

Background: While increases in obesity over the past 30 years have adversely affected population health, there have been concomitant improvements due to reductions in smoking. Better understanding of the joint effects of these trends on longevity and quality of life will help policymakers target resources more efficiently. Methods: For each year from 2005 to 2020, we forecast life expectancy and qualityadjusted life expectancy for a representative 18 year old, assuming a continuation of past...

The hydrogen village: building hydrogen and fuel cell opportunities

International Nuclear Information System (INIS)

Smith, R.

2006-01-01

The presentation addressed the progress the Hydrogen Village Program has made in its first 24 months of existence and will provide an understanding of the development of new markets for emerging Hydrogen and Fuel Cell technologies based on first hand, real world experience. The Hydrogen Village (H2V) is an End User driven, Market Development Program designed to accelerate the sustainable commercialization of hydrogen and fuel cell technologies through awareness, education and early deployments throughout the greater Toronto area (GTA). The program is a collaborative public-private partnership of some 35 companies from a broad cross section of industry administered through Hydrogen and Fuel Cells Canada and funded by the Governments of Canada and Ontario. The intent of the H2V is to develop markets for Hydrogen and Fuel Cell technologies that benefit the local and global community. The following aspects of market development are specifically targeted: 1) Deployments: of near market technologies in all aspects of community life (stationary and mobile). All applications must be placed within the community and contact peoples in their day-to-day activity. End user involvement is critical to ensure that the applications chosen have a commercial justification and contribute to the complementary growth of the market. 2) Development: of a coordinated hydrogen delivery and equipment service infrastructure. The infrastructure will develop following the principles of conservation and sustainability. 3) Human and societal factors: - Public and Corporate policy, public education, Codes/ Standards/ Regulations - Opportunity for real world implementation and feedback on developing codes and standards - Build awareness among regulatory groups, public, and the media. The GTA Hydrogen Village is already well under way with strategically located projects covering a wide range of hydrogen and fuel cell applications including: Residential heat and power generation using solid oxide

Phylogenomics reveal a robust fungal tree of life

NARCIS (Netherlands)

Kuramae, Eiko E.; Robert, Vincent; Snel, Berend; Weiß, Michael; Boekhout, Teun

2006-01-01

Our understanding of the tree of life (TOL) is still fragmentary. Until recently, molecular phylogeneticists have built trees based on ribosomal RNA sequences and selected protein sequences, which, however, usually suffered from lack of support for the deeper branches and inconsistencies probably

An Overview of New Progresses in Understanding Pipeline Corrosion

Energy Technology Data Exchange (ETDEWEB)

Tan, M. YJ; Varela, F.; Huo, Y.; Gupta, R.; Abreu, D.; Mahdavi, F.; Hinton, B.; Forsyth, M. [Deakin University, Victoria (Australia)

2016-12-15

An approach to achieving the ambitious goal of cost effectively extending the safe operation life of energy pipeline to 100 years is the application of health monitoring and life prediction tools that are able to provide both long-term remnant pipeline life prediction and in-situ pipeline condition monitoring. A critical step is the enhancement of technological capabilities that are required for understanding and quantifying the effects of key factors influencing buried steel pipeline corrosion and environmentally assisted materials degradation, and the development of condition monitoring technologies that are able to provide in-situ monitoring and site-specific warning of pipeline damage. This paper provides an overview of our current research aimed at developing new sensors and electrochemical cells for monitoring, categorising and quantifying the level and nature of external pipeline and coating damages under the combined effects of various inter-related variables and processes such as localised corrosion, coating cracking and disbondment, cathodic shielding, transit loss of cathodic protection.

The double-loop feedback for active learning with understanding

DEFF Research Database (Denmark)

Christensen, Hans Peter

2004-01-01

Learning is an active process, and in engineering education authentic projects is often used to activate the students and promote learning. However, it is not all activity that leads to deep learning; and in a rapid changing society deep understanding is necessary for life-long learning. Empirical...... findings at DTU question the direct link between high activity and a deep approach to learning. Active learning is important to obtain engineering competencies, but active learning requires more than activity. Feedback and reflection is crucial to the learning process, since new knowledge is built...... on the student’s existing understanding. A model for an active learning process with a double-loop feedback is suggested - the first loop gives the student experience through experimentation, the second conceptual understanding through reflection. Students often miss the second loop, so it is important...

Important Issues to Quality of Life Among Norwegian Older Adults: An Exploratory Study

OpenAIRE

Kalfoss, Mary; Halvorsrud, Liv

2009-01-01

The increasing numbers of older people and higher expectations of a ?good life? within societies, has lead to international interest in the enhancement of quality of life (QoL) among older adults. Understanding whether the same aspects of life are equally important to the life quality of subgroups of older people is important in helping health professionals plan social and health care policy and caring strategies. The purpose of this study was to describe the importance given to 38 areas of Q...

How Does Work-Life Balance Influence Expatriates’ Working Performance? : The Case of Malaysia

OpenAIRE

Ahmad Zahar, Nur Yuha Zulaikha

2011-01-01

This research examines the important factors that play significant parts in the life of expatriates as they attempt to gain work-life balance. If reaching work-life balance is important for an employee, it is even far more important for expatriates as they face a lot of challenges living thousands of miles away from their family members and friends whom they always seek support from. Understanding the true meaning of work-life balance is essential as it mirrors how the expatriate’s performanc...

Bugs, butterflies, and spiders: children's understandings about insects

Science.gov (United States)

Shepardson, Daniel P.

2002-06-01

This article explores elementary children's ideas about insects. The study involved 20 children from each grade level, kindergarten through fifth-grade, for a total of 120 children. The data collection procedure was designed to investigate what an insect means to children, through the use of three different tasks: draw and explain, interview about instances, and the formulation of a general rule. Considering children's responses to the three tasks, I found that their ideas about insects reflect understandings based on physical characteristics of size and shape, arthropod characteristics, insect characteristics, human-insect interactions, life habits of insects, feeding habits of insects, and means of locomotion. Children's understandings are juxtaposed to that of a scientific perspective, elucidating implications for curriculum development and instructional practice.

Facing Fanon: Examining Neocolonial Aspects in Grand Theft Auto V through the Prism of the Machinima Film Finding Fanon II

Directory of Open Access Journals (Sweden)

Steffen Krüger

2018-02-01

Full Text Available In this article, I examine the Machinima film 'Finding Fanon II', by London-based artists Larry Achiampong and David Blandy, for what it can tell us about the relationship between video gaming and the postcolonial. Evoking Frantz Fanon, one of the most piercing voices of the decolonisation movement of the 1950s and 1960s, in the context of 'Grand Theft Auto' (GTA, one of the most technologically advanced and, at the same time, scandalous video game series of the 21st century, 'Finding Fanon II' amounts to a scathing critique of both the game series’ depiction of race and academic scholarship that has been defending the series on the grounds of its use of humour and irony. Shot in the in-game video editor of 'GTA V', 'Finding Fanon II' lets this critique emerge from inside the game and as an effect of the artists’ engagement with it. By suspending the game’s mechanisms and programmed forms of interaction, the artwork brings their racialised logic to the fore, pointing towards the ways in which 'GTA V' commodifies black men for the consumption of white players. This commodification has the effect of normalising and naturalising the precarious position of black people in Western society. What the artwork adds to this argument through its facilitation of a Fanonian perspective is a reminder that it is not only the gaming experience of 'white' players that is framed in this way. Players with ethnic minority backgrounds might also accept the white gaze of the game as a given. Acts of self-commodification along the lines of a white Western rationality must thus be seen as a plausible new form of cultural imperialism promoted by the GTA series.

Weldability of molybdenum and its alloy sheet, 1

International Nuclear Information System (INIS)

Matsuda, Fukuhisa; Ushio, Masao; Nakata, Kazuhiro; Edo, Yoshiaki

1979-01-01

Basic weldability of electron-beam melted pure molybdenum has been examined in electron-beam welding in high vacuum and GTA welding in pure and air mixed argon atmospheres by paying attention to weld defects such as hot cracking and porosity in weld metal and also mechanical properties of welded joint in comparison with conventional TZM alloys. The main conclusions obtained were as follows; (1) The weld metals of electron-beam melted pure molybdenum with electron-beam and GTA weldings in pure and air mixed argon atmosphere up to about 1% were almost porosity free. However, large amount of oxygen content of 200 ppm in powder-metallurgy TZM alloy made very porous weld bead in electron-beam welding in high vacuum. Therefore, oxygen content in base metal should be lowered to the minimum, that is, less than 10 ppm, especially in electron-beam welding in high vacuum. (2) Hot cracking occurred in the weld metal of GTA welding when air content in argon atmosphere exceeded about 0.6% for electron-beam melted pure molybdenum and powder metallurgy TZM alloy. In less than 0.26% air, no hot cracking were observed in this experiment. Moreover, in electron-beam welding, no hot cracking was observed in weld metals for both materials. In order to prevent the formation of hot cracking, the purity of welding atmosphere should be kept as high as possible. (3) Joint efficiency of the welded joint of electron-beam melted pure molybdenum with electron-beam welding was 50 to 60% to base metal at room temperature and 500 0 C and almost 100% at 1000 0 C. Those of GTA welds in pure and 0.13% air mixed argon atmospheres were fairly lower than those in electron-beam welding for each testing temperature. (author)

Life in a dark biosphere: a review of circadian physiology in "arrhythmic" environments.

Science.gov (United States)

Beale, Andrew David; Whitmore, David; Moran, Damian

2016-12-01

Most of the life with which humans interact is exposed to highly rhythmic and extremely predictable changes in illumination that occur with the daily events of sunrise and sunset. However, while the influence of the sun feels omnipotent to surface dwellers such as ourselves, life on earth is dominated, in terms of biomass, by organisms isolated from the direct effects of the sun. A limited understanding of what life is like away from the sun can be inferred from our knowledge of physiology and ecology in the light biosphere, but a full understanding can only be gained by studying animals from the dark biosphere, both in the laboratory and in their natural habitats. One of the least understood aspects of life in the dark biosphere is the rhythmicity of physiology and what it means to live in an environment of low or no rhythmicity. Here we describe methods that may be used to understand rhythmic physiology in the dark and summarise some of the studies of rhythmic physiology in "arrhythmic" environments, such as the poles, deep sea and caves. We review what can be understood about the adaptive value of rhythmic physiology on the Earth's surface from studies of animals from arrhythmic environments and what role a circadian clock may play in the dark.

Thermal and Mechanical Design Aspects of the LIFE Engine

Energy Technology Data Exchange (ETDEWEB)

Abbott, R P; Gerhard, M A; Latkowski, J F; Kramer, K J; Morris, K R; Peterson, P F; Seifried, J E

2008-10-25

The Laser Inertial confinement fusion - Fission Energy (LIFE) engine encompasses the components of a LIFE power plant responsible for converting the thermal energy of fusion and fission reactions into electricity. The design and integration of these components must satisfy a challenging set of requirements driven by nuclear, thermal, geometric, structural, and materials considerations. This paper details a self-consistent configuration for the LIFE engine along with the methods and technologies selected to meet these stringent requirements. Included is discussion of plant layout, coolant flow dynamics, fuel temperatures, expected structural stresses, power cycle efficiencies, and first wall survival threats. Further research and to understand and resolve outstanding issues is also outlined.

Harmonization of gender roles as a basis for life quality

Directory of Open Access Journals (Sweden)

Nešić Ana

2017-01-01

Full Text Available Activities that determine the quality of life are related to environmental factors, economic factors, social and personal factors that largely determine the relationships among people and, especially, relations between genders. Particularly important for the quality of life is work, development and work results. Career is now perceived as a development of our own competencies, understanding of the meaning of work through the integration of psychological, sociological, educational, physical and economic factors, which together form the individual's career in life. Women's career developments are often different from men's, due to the phenomenon of the glass ceiling, which represents an invisible barrier to the advancement of women, and which often influences their behaviour. Harmonization of gender roles in business and private life of women is imperative to improve the quality of life all citizens.

Double Voicing and Personhood in Collaborative Life Writing about Autism: the Transformative Narrative of Carly's Voice.

Science.gov (United States)

Orlando, Monica

2018-06-01

Collaborative memoirs by co-writers with and without autism can enable the productive interaction of the voices of the writers in ways that can empower rather than exploit the disabled subject. Carly's Voice, co-written by Arthur Fleischmann and his autistic daughter Carly, demonstrates the capacity for such life narratives to facilitate the relational interaction between writers in the negotiation of understandings of disability. Though the text begins by focusing on the limitations of life with autism, it develops into a collaboration which helps both writers move toward new ways of understanding disability and their own and one another's life stories.

Allergy immunotherapy across the life cycle to promote active and healthy ageing: From research to policies

NARCIS (Netherlands)

M. Calderon (Moises); P. Demoly; T.B. Casale (Thomas); C.A. Akdis; C. Bachert (Claus); Bewick, M.; Bilò, B.M.; B. Bohle (B.); S. Bonini (Sergio); A. Bush (Andrew); Caimmi, D.P.; G. Canonica (Gwalter); D. Cardona (Doris); A.M. Chiriac (A.); L. Cox (Linda); A. Custovic; F. de Blay; Devillier, P.; Didier, A.; Di Lorenzo, G.; G. Du Toit (George); S.R. Durham (Stephen); C. Eng (Charis); A. Fiocchi (Alessandro); Fox, A.T.; R. Gerth van Wijk (Roy); Gomez, R.M.; Haathela, T.; S. Halken (Susanne); P.W. Hellings (Peter); L. Jacobsen; P.M. Just; Tanno, L.K.; J. Kleine-Tebbe (Jörg); L. Klimek (Ludger); E.F. Knol (Edward Frank); P. Kuna; D. Larenas-Linnemann (Désirée); A. Linneberg (Allan); Matricardi, M.; H.-J. Malling; Moesges, R.; Mullol, J.; Muraro, A.; N. Papadopoulos; G. Passalacqua (Giovanni); Pastorello, E.; O. Pfaar (Oliver); D. Price (David); P.R. Del Rio (P. Rodriguez); Ruëff, R.; Samolinski, B.; G.K. Scadding; Senti, G.; Shamji, M.H.; A. Sheikh (Aziz); J.C. Sisul (J.); D. Solé (D.); G.J. Sturm; Tabar, A.; R. Van Ree; Ventura, M.T.; C. Vidal (Carmen); E.M. Varga; M. Worm (M.); T. Zuberbier (Torsten); J. Bousquet (Jean)

2016-01-01

textabstractAllergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a

Life changes and depressive symptoms: the effects of valence and amount of change

NARCIS (Netherlands)

Bennik, Elise C.; Ormel, Johan; Oldehinkel, Albertine J.

2013-01-01

Background Only few studies have focused on the effects of positive life changes on depression, and the ones that did demonstrated inconsistent findings. The aim of the present study was to obtain a better understanding of the influence of positive life changes on depressive symptoms by decomposing

Understanding Teacher Practice using their own Narratives

DEFF Research Database (Denmark)

Daugbjerg, Peer Schrøder

2010-01-01

This paper discusses ways of understanding teacher practice in educational settings. An educational setting consists of cultural, social and historical elements that all influence the teacher’s practice and, how she experiences this practice. It is argued that teaching science and technology...... is a socially conditioned practice. The teachers’ practice are formed by their previous education and experience but also influenced by their private life. This way of looking at teacher knowledge and experience requires attention to teachers’ perception of these aspects. Teachers seldom talk about...

Towards a definition of life.

Science.gov (United States)

Macklem, Peter T; Seely, Andrew

2010-01-01

This article offers a new definition of life as a "self-contained, self-regulating, self-organizing, self-reproducing, interconnected, open thermodynamic network of component parts which performs work, existing in a complex regime which combines stability and adaptability in the phase transition between order and chaos, as a plant, animal, fungus, or microbe." Open thermodynamic networks, which create and maintain order and are used by all organisms to perform work, import energy from and export entropy into the environment. Intra- and extracellular interconnected networks also confer order. Although life obeys the laws of physics and chemistry, the design of living organisms is not determined by these laws, but by Darwinian selection of the fittest designs. Over a short range of normalized energy consumption, open thermodynamic systems change from deeply ordered to chaotic, and life is found in this phase transition, where a dynamic balance between stability and adaptability allows for homeokinesis. Organisms and cells move within the phase transition with changes in metabolic rate. Seeds, spores and cryo-preserved tissue are well within the ordered regime, while health probably cannot be maintained with displacements into the chaotic regime. Understanding life in these terms may provide new insights into what constitutes health and lead to new theories of disease.

Quality of life theory III. Maslow revisited.

Science.gov (United States)

Ventegodt, Søren; Merrick, Joav; Andersen, Niels Jørgen

2003-10-13

In 1962, Abraham Maslow published his book Towards a Psychology of Being, and established a theory of quality of life, which still is considered a consistent theory of quality of life. Maslow based his theory for development towards happiness and true being on the concept of human needs. He described his approach as an existentialistic psychology of self-actualization, based on personal growth. When we take more responsibility for our own life, we take more of the good qualities that we have into use, and we become more free, powerful, happy, and healthy. It seems that Maslow's concept of self-actualization can play an important role in modern medicine. As most chronic diseases often do not disappear in spite of the best biomedical treatments, it might be that the real change our patients have for betterment is understanding and living the noble path of personal development. The hidden potential for improving life really lies in helping the patient to acknowledge that his or her lust for life, his or her needs, and his or her wish to contribute, is really deep down in human existence one and the same. But you will only find this hidden meaning of life if you scrutinize your own life and existence closely enough, to come to know your innermost self.

Quality of Life Theory III. Maslow Revisited

Directory of Open Access Journals (Sweden)

Soren Ventegodt

2003-01-01

Full Text Available In 1962, Abraham Maslow published his book Towards a Psychology of Being, and established a theory of quality of life, which still is considered a consistent theory of quality of life. Maslow based his theory for development towards happiness and true being on the concept of human needs. He described his approach as an existentialistic psychology of self-actualization, based on personal growth.When we take more responsibility for our own life, we take more of the good qualities that we have into use, and we become more free, powerful, happy, and healthy. It seems that Maslow�s concept of self-actualization can play an important role in modern medicine. As most chronic diseases often do not disappear in spite of the best biomedical treatments, it might be that the real change our patients have for betterment is understanding and living the noble path of personal development. The hidden potential for improving life really lies in helping the patient to acknowledge that his or her lust for life, his or her needs, and his or her wish to contribute, is really deep down in human existence one and the same. But you will only find this hidden meaning of life if you scrutinize your own life and existence closely enough, to come to know your innermost self.

Disorder and Everyday Life in Barrancabermeja

Directory of Open Access Journals (Sweden)

Lesley Gill

2011-06-01

Full Text Available This article examines how years of political violence and neoliberal restructuring have disorganized social life in Barrancabermeja. How, it asks, can working people grasp the future without the stability to understand the present and the ways that it both emerges and is different from the past? It explores how an extreme form of neoliberalism fragmented various forms of social solidarity, infused social life with fear, and generated violent, clientelistic networks that flourished in the absence of rights. It argues that unrestrained power and violence deprived people of the coherence needed to take care of themselves and to grasp the connections between the past, present, and future that are necessary “to make history.”

Health profile and quality of life of elderly with hypertension

Directory of Open Access Journals (Sweden)

Gabriela Freire de Almeida Vitorino

2015-12-01

Full Text Available Objective: to evaluate the quality of life of hypertensive elderly women in the Family Health Strategy. Method: cross-sectional, descriptive and quantitative study that evaluated 60 hypertensive older women using the tool World Health Organization Quality of Life with 26 items divided into four domains: social relations, psychological, physical and environment. Results: regarding the quality of life in all domains, except the psychological domain, the quality of life was considered regular. The psychological domain demonstrated a quality of life that needs to improve. Some questions are presented as unsatisfactory, such as the items: pain and discomfort, dependence on antihypertensive medications, negative feelings, lack of health care and recreation. Conclusion: understanding the health profile and the quality of life of hypertensive elderly women allows better knowledge about them and their adaptation to the condition imposed by the disease, offering support for planning care strategies and health education interventions.

His or her work-life Balance? Experiences of self-employed immigrant parents

OpenAIRE

Munkejord, Mai Camilla

2016-01-01

The question of how to achieve ‘work–life balance’ has been a central debate for several decades. Hitherto, this subject has primarily been explored in organizational contexts; less is known in the context of self-employment. This article advances our understanding of work–life balance by analysing the everyday stories of self-employed immigrant parents in Norway. In this study, work– life balance is constructed in contrasting ways between mothers and fathers on the individual lev...

Nano-Launcher Technologies, Approaches, and Life Cycle Assessment. Phase II

Science.gov (United States)

Zapata, Edgar

2014-01-01

Assist in understanding NASA technology and investment approaches, and other driving factors, necessary for enabling dedicated nano-launchers by industry at a cost and flight rate that (1) could support and be supported by an emerging nano-satellite market and (2) would benefit NASAs needs. Develop life-cycle cost, performance and other NASA analysis tools or models required to understand issues, drivers and challenges.

An Exploratory Study of Advancing Mobilization in the Life Insurance Industry: The Case of Taiwan's Nan Shan Life Insurance Corporation.

Science.gov (United States)

Luarn, Pin; Lin, Tom M. Y.; Lo, Peter K. Y.

2003-01-01

Employs a case study method, using in-depth interviews of 29 corporate managers and experts, to understand the current state of mobilization in the life insurance industry. Suggests a conceptual framework and formulates possible research propositions incorporating several variables. Suggests 10 key success factors for implementing mobilization in…

Studies of Life on Earth are Important for Mars Exploration

Science.gov (United States)

DesMarais, D. J.

1998-01-01

The search for evidence of the early martian environment and a martian biosphere is benefitted by diverse studies of life on Earth. Most fundamentally, origin-of-life research highlights the challenge in formulating a rigorous definition of life. Because such definitions typically list several of life's most basic properties, they also help to define those observable features that distinguish life and thus might be sought through telescopes, spacecraft, and analyses of extraterrestrial samples. Studies of prebiotic chemistry also help by defining the range of environments and processes that sustain prebiotic organic synthesis. These studies might indicate if and where prebiotic processes occur today on Earth and elsewhere. Such studies should also help to identify which localities are good candidates for the origin of life. A better understanding of the most fundamental principles by which molecules are assembled into living systems will help us to appreciate possible alternatives to the path followed by life on Earth. These perspectives will sharpen our ability to recognize exotic life and/or those environments that can sustain it.

Corticosterone and pace of life in two life-history ecotypes of the garter snake Thamnophis elegans.

Science.gov (United States)

Palacios, Maria G; Sparkman, Amanda M; Bronikowski, Anne M

2012-02-01

Glucocorticoids are main candidates for mediating life-history trade-offs by regulating the balance between current reproduction and survival. It has been proposed that slow-living organisms should show higher stress-induced glucocorticoid levels that favor self-maintenance rather than current reproduction when compared to fast-living organisms. We tested this hypothesis in replicate populations of two ecotypes of the garter snake (Thamnophis elegans) that exhibit slow and fast pace of life strategies. We subjected free-ranging snakes to a capture-restraint protocol and compared the stress-induced corticosterone levels between slow- and fast-living snakes. We also used a five-year dataset to assess whether baseline corticosterone levels followed the same pattern as stress-induced levels in relation to pace of life. In accordance with the hypothesis, slow-living snakes showed higher stress-induced corticosterone levels than fast-living snakes. Baseline corticosterone levels showed a similar pattern with ecotype, although differences depended on the year of study. Overall, however, levels of glucocorticoids are higher in slow-living than fast-living snakes, which should favor self-maintenance and survival at the expense of current reproduction. The results of the present study are the first to relate glucocorticoid levels and pace of life in a reptilian system and contribute to our understanding of the physiological mechanisms involved in life-history evolution. Copyright © 2011 Elsevier Inc. All rights reserved.