Understanding the Pathogenesis of Angelman Syndrome through Animal Models

Directory of Open Access Journals (Sweden)

Nihar Ranjan Jana

2012-01-01

Full Text Available Angelman syndrome (AS is a neurodevelopmental disorder characterized by severe mental retardation, lack of speech, ataxia, susceptibility to seizures, and unique behavioral features such as easily provoked smiling and laughter and autistic features. The disease is primarily caused by deletion or loss-of-function mutations of the maternally inherited UBE3A gene located within chromosome 15q11-q13. The UBE3A gene encodes a 100 kDa protein that functions as ubiquitin ligase and transcriptional coactivator. Emerging evidence now indicates that UBE3A plays a very important role in synaptic function and in regulation of activity-dependent synaptic plasticity. A number of animal models for AS have been generated to understand the disease pathogenesis. The most widely used model is the UBE3A-maternal-deficient mouse that recapitulates most of the essential features of AS including cognitive and motor abnormalities. This paper mainly discusses various animal models of AS and how these models provide fundamental insight into understanding the disease biology for potential therapeutic intervention.

Den Gode Historie

DEFF Research Database (Denmark)

Mogensen, T.E.

den nysgerrige læser af trilogien. Den kan beses og bestilles på: www.universitypress.dk/DK/detail.php?token=73278292116&R=8778387078&N=nej ELLER KØB DEN DIREKTE HOS MIG: SLAGTILBUD 100 kr. (inkl. porto og forsendelse)!                            Henvendelse pr. e-mail til tine.engel@gmail.com...

Den økonomiske verdensorden

DEFF Research Database (Denmark)

Ougaard, Morten

2016-01-01

. Men det er ikke en statisk orden, den har udviklet og forandret sig gennem de sidste 70 år, og det er ikke første gang, den står over for betydelige udfordringer. Derfor er det instruktivt at kaste et blik bagud. De nuværende vanskeligheder skal ses på baggrund af den historie, der har skabt dem, og...

Den iscenesatte virkelighed

DEFF Research Database (Denmark)

Bondebjerg, Ib

2007-01-01

Artiklen diskuterer den dramatiserede dokumentarismes forskellige genrer inden for film og tv. Det diskuteres hvor grænserne mellem fiktion og fakta går i journalistik og dokumentarisme. Hovedkonklusionen er, at den dramatiserede og iscenesatte dokumentarisme er en genre, der har en vigtig funktion...

Den katolske kirke

DEFF Research Database (Denmark)

Olden-Jørgensen, Sebastian

2009-01-01

En kort gennemgang af den katolske kirkes kirkerum, ritualer, selvforståelse og syn på andre kristne efterfulgt af 16 forskellige kildetekster til belysning og uddybning af emnerne. Bogen omfatter tilsvarende afsnit om de ortodokse kirker og om folkekirken. Den er beregnet til gymnasium og HF....

Den moderate revolution

DEFF Research Database (Denmark)

Larsen, Bøje

"normale" industrivirksomheder, men den er absolut set begrænset. Årsagerne til denne kun "moderate revolution" af organisationsformerne diskuteres: Er det fordi klassisk organisation og social nærkontakt er nødvendig i den nye økonomi, eller er det manglende fantasi og tryghedsbehov? Begge muligheder...

Hvad karakteriserer den netbaserede vejledning?

DEFF Research Database (Denmark)

Kjeldsen, Lars Peter

2008-01-01

Hensigten med artiklen er at bidrage til forståelsen af sider ved den netbaserede vejledning. Fremgangsmåden vil være: •Først at beskrive og diskutere, hvorledes jeg forstår det virtuelle læringsmiljø, herunder en afklaring af, hvad der karakteriserer den netbaserede vejledning. •Dernæst gennem e...... teoretisk afsæt opstille en model for, hvorledes netbaseret vejledning kan bidrage til de studerendes læreproces. • Sidst at give eksempler på hvorledes modellen for netbaseret vejledning kan anvendes i praksis.......Hensigten med artiklen er at bidrage til forståelsen af sider ved den netbaserede vejledning. Fremgangsmåden vil være: •Først at beskrive og diskutere, hvorledes jeg forstår det virtuelle læringsmiljø, herunder en afklaring af, hvad der karakteriserer den netbaserede vejledning. •Dernæst gennem et...

Den sociale stofmisbrugsbehandling. Del 4

DEFF Research Database (Denmark)

Sørensen, Maren

Dette er den fjerde delrapport i en rapportserie om den sociale stofmisbrugsbehandling i Danmark. Rapportserien bygger på en omfattende undersøgelse, der blev fortaget i perioden december 2007 til maj 2009. Denne delrapport stiller skarpt på kvalitetsudvikling og kvalitetsstandarder i den sociale...

Radiomontagen og dens radiofoniske rødder. Om hørebilledet, den litterære tekstmontage, featuren og den moderne radiomontage

Directory of Open Access Journals (Sweden)

Ib Poulsen

2001-09-01

Full Text Available Radiomontagen og dens genrevarianter, hørebilledet og featuren har tidligere har tidligere været genstand for interesse fra især den æste- tiske og tekstanalytisk orienterede radioforskning. I denne artikel sæt- tes genren ind i en bredere kontekst, sociokulturelt og medie- og insti- tutionshistorisk. Ledetrådene i den diakrone fremstilling er dels spørgs- målet om genrens historiske og genremæssige rødder, dels en kombi- neret tekstanalytisk og receptionsæstetisk tilgang, der søger at ind- kredse de positioneringer af lytteren, radiomontagen og dens varianter tilbyder. Artiklen er baseret på grundige arkivstudier i DR og på inter- views med nogle af de ’montører’, som har bidraget til udviklingen af montagen, der i kraft af sin radiofoniske spændvidde mest vedholdende og varieret har forsøgt at udforske menneskets livssituation i den moder- ne verden, samtidig med at lytteren er blevet tilbudt en lytteposition, der prioriterer refleksion og eftertanke.

Den sociale stofmisbrugsbehandling. Del 6

DEFF Research Database (Denmark)

Sørensen, Maren; Buchholt Pedersen, Katrine

Dette er den sjette delrapport i en rapportserie om den sociale stofmisbrugsbehandling i Danmark. Rapportserien bygger på en omfattende undersøgelse, der blev fortaget i perioden december 2007 til maj 2009. Denne delrapport stiller skarpt på resultaterne af den sociale stofmisbrugsbehandling i Da...

Døden på glas

DEFF Research Database (Denmark)

Meyer, Ion

2008-01-01

Artiklen beskriver den eneste danske samling af præparerede fostre og børn, og hvorfor den blev fremstillet. Den var en del af Museum Saxtorphianum og artiklen diskuterer hvordan disse fostre blev til præparater. Musealiseringen, overgangen fra medicinske studieobjekter til museumsgenstande med s...

Die grossen Physiker und ihre Entdeckungen von den fallenden Körpern zu den Quarks

CERN Document Server

Segrè, Emilio

1998-01-01

Von Galileo Galilei bis zu Richard Feynman und Murray Gell-Mann - von den fallenden Körpern zu den Quarks: Der Physiknobelpreisträger Emilio Segre hat seine ganz persönliche Geschichte der Physik geschrieben. Er erzählt von den großen Gestalten und deren wichtigen Entdeckungen mit großer Anschaulichkeit und Lebendigkeit.

Medarbejderdreven innovation i den offentlige sektor

DEFF Research Database (Denmark)

Klitmøller, Anders; Lauring, Jakob; Christensen, Poul Rind

2007-01-01

Denne artikel har til formål at kaste lys over den rolle, medarbejderne spiller for den innovative aktivitet i den offentlige sektor, hvad vi har valgt at kalde medarbejderdreven innovation. Artiklen er baseret på et etnografisk feltstudie i Århus Kommune, nærmere bestemt den nye afdeling...

Den menneskelige plet

DEFF Research Database (Denmark)

Kjerkegaard, Stefan

endog en selvstigmatisering, hvor selvfortællingen ikke hænger sammen. Der er tale om en menneskelig henvendelse inkorporeret i det, som litteraturen gør, snarere end i det, den siger. I den nye danske litteratur af eksempelvis Yahya Hassan, Asta Olivia Nordenhof eller Bjørn Rasmussen oplever man...

Den kulturelle dimension af virksomhedens internationalisering

DEFF Research Database (Denmark)

Langhoff, Tine

1994-01-01

Artiklen omhandler den kulturelle dimensions indvirkning på virksomhedens internationalisering og diskuterer mulige internationalisieringsstrategier for virksomheder, der konfronteres med kulturforskelle. Med udgangspunkt i en kritik af den hidtidige forskning på området, hvor det såkaldte psykiske...... distancebegreb har haft en central placering, foreslås det, at man som alternativ til dette begreb skal fokusere på virksomhedens markedsbaserede innovationsevne. Denne betegnes som dens interkultu kompetence og vedrører dens evne til at identificere og udnytte muligheder i fremmede kulturelle sammenhænge. Det...... er herved, at den kulturelle dimension påvirker virksomheden og dens fortsatte udvikling. En empirisk analyse i den danske fødevarebranche afdækker virksomheders interkulturelle kompetence ved hjælp af to spørgsmål: (1) Hvorledes formår virksomheder med begrænsede ressourcer til deres disposition...

Forever Young - den norske tv-serie Skam

DEFF Research Database (Denmark)

Jerslev, Anne

2016-01-01

Hvorfor er det lige, at den norske netbaserede ungdomsserie "Skam" er på alles læber for tiden? Svaret er simpelt: Den er nyskabende og supergod, og den taler til en langt bredere målgruppe end den gruppe af teenagepiger, den er rettet mod....

Den levende sangfugl

DEFF Research Database (Denmark)

Bjerre, Thomas Ærvold

2009-01-01

Kronik om Harper Lee's roman "Dræb ikke en sangfugl" (1960) og den store indflydelse bog og film har haft på amerikansk kultur. Udgivelsesdato: 30. juli......Kronik om Harper Lee's roman "Dræb ikke en sangfugl" (1960) og den store indflydelse bog og film har haft på amerikansk kultur. Udgivelsesdato: 30. juli...

Food Allergy: Our Evolving Understanding of Its Pathogenesis, Prevention, and Treatment.

Science.gov (United States)

Iweala, Onyinye I; Burks, A Wesley

2016-05-01

Food allergy is defined as an IgE-mediated hypersensitivity response to ingested food with allergic symptoms ranging from urticaria to life-threatening anaphylaxis. Food allergy is thought to develop because of (1) failed induction of tolerance upon initial exposure to food antigen or (2) breakdown of established tolerance to food antigen. We review current understanding of the pathogenesis, epidemiology, and natural history of food allergy, including the unconventional IgE-mediated food allergy to mammalian meat known as alpha-gal food allergy. We highlight emerging data on food allergy treatment and prevention, emphasizing the growing appeal of manipulating the gut microenvironment using probiotics and helminth products to blunt systemic allergic responses to food.

Dannelsen af den ansvarlige elev

DEFF Research Database (Denmark)

Larsen, Jesper

2010-01-01

Denne artikel handler om den del af lærergerningen, der har at gøre med udarbejdelse af elevplaner. Der tages udgangspunkt i en foucaultsk forståelse, hvor beskrivelsen af den enkelte elev udtrykker et særligt normativt ideal om, hvilke former for elevhed der er de ønskværdige i den danske...

Den professionelle samtale

DEFF Research Database (Denmark)

Herskind, Mia

2012-01-01

, som et sådant perspektiv indebærer. Kapitlet tager afsæt i forskellige typer af professionelle samtaler (interview, supervision og terapi), hvor den professionelle stiller spørgsmål og er til stede på måder, så også den prærefleksive og kropslige-sanselige fortælling bliver en del af samtalen. Det...

Den signede dag

DEFF Research Database (Denmark)

Balslev-Clausen, Peter

2010-01-01

Artiklen gennemgår de tre middelalderlige versioner af den fællesnordiske dagvise fra 14. århundrede og gør rede for salmens tekst- og receptionshistorie i Dansk tradition.......Artiklen gennemgår de tre middelalderlige versioner af den fællesnordiske dagvise fra 14. århundrede og gør rede for salmens tekst- og receptionshistorie i Dansk tradition....

Conservative management of dens evaginatus and attached supernumerary tooth/odontome in mandibular premolar with dual radiolucencies

Directory of Open Access Journals (Sweden)

Naseem Shah

2015-01-01

Full Text Available Recently, an innovative, nonsurgical regenerative endodontic treatment protocol “SealBio” was introduced to manage mature nonvital permanent teeth with periapical lesions. This paper explains the management of an unusual case of dens evaginatus and an attached supernumerary tooth/an odontome associated with two distinct radiolucencies in a mandibular premolar with “SealBio” technique and discusses the various hypotheses on the pathogenesis of unusual malformation and associated pericervical cyst-like radiolucency in the involved tooth.

Den moderne tyske roman 1909-35

DEFF Research Database (Denmark)

Ved siden af klassikken og romantikken er den tidlige modernisme vel nok den betydeligste periode i tysksproget litteratur. Det skyldes ikke mindst den perlerække af romaner, der udkom i første tredjedel af det 20. århundrede, og hvoraf mange i dag fremstår som indiskutable højdepunkter i såvel...... tysk som europæisk roman- og litteraturhistorie. I Den moderne tyske roman 1909-35 behandles en række af disse romaner for første gang samlet på dansk. Bogen består af otte romanfortolkninger samt en indledende artikel om den moderne romans historie og særpræg. Alle artikler er skrevet med et solidt...... interesserede læser. I overensstemmelse med dens formidlende sigte er der kun medtaget fortolkninger af romaner, der foreligger på dansk i en tidssvarende oversættelse. Af hensyn til den litteraturhistoriske bredde er der desuden kun medtaget én roman af samme forfatter.Bogen indeholder analyser af: Robert...

Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis.

Science.gov (United States)

Martin, Roland; Sospedra, Mireia; Rosito, Maria; Engelhardt, Britta

2016-09-01

Multiple sclerosis (MS) is the most common inflammatory disorder of the central nervous system (CNS) in young adults. When MS is not treated, it leads to irreversible and severe disability. The etiology of MS and its pathogenesis are not fully understood. The recent discovery that MS-associated genetic variants code for molecules related to the function of specific immune cell subsets is consistent with the concept of MS as a prototypic, T-cell-mediated autoimmune disease targeting the CNS. While the therapeutic efficacy of the currently available immunomodulatory therapies further strengthen this concept, differences observed in responses to MS treatment as well as additional clinical and imaging observations have also shown that the autoimmune pathogenesis underlying MS is much more complex than previously thought. There is therefore an unmet need for continued detailed phenotypic and functional analysis of disease-relevant adaptive immune cells and tissues directly derived from MS patients to unravel the immune etiology of MS in its entire complexity. In this review, we will discuss the currently available MS treatment options and approved drugs, including how they have contributed to the understanding of the immune pathology of this autoimmune disease. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Efterskrift til den reviderede udgave

DEFF Research Database (Denmark)

Nielsen, Carsten Fogh

2017-01-01

Opsummering af tendenser og udviklingstræk inden for den nyere forskning i Kants historiefilosofi.......Opsummering af tendenser og udviklingstræk inden for den nyere forskning i Kants historiefilosofi....

Human disturbances of denning polar bears in Alaska

International Nuclear Information System (INIS)

Amstrup, S.C.

1993-01-01

Polar bears (Ursus maritimus) give birth in dens of snow and ice. The altricial neonates cannot leave the den for >2 months post-partum and are potentially vulnerable to disturbances near dens. The coastal plain (1002) area of Alaska's Arctic National Wildlife Refuge (ANWR) lies in a region of known polar bear denning and also may contain >9 billion barrels of recoverable oil. Polar bears in dens could be affected in many ways by hydrocarbon development. The distribution of dens on ANWR was documented between 1981 and 1992 and responses of bears in dens to various anthropogenic disturbances were observed. Of 44 dens located by radiotelemetry on the mainland coast of Alaska and Canada, 20 (45%) were on ANWR and 15 (34%) were within the 1002 area. Thus, development of ANWR will increase the potential that denning polar bears are disturbed by human activities. However, perturbations resulting from capture, marking, and radiotracking maternal bears did not affect litter sizes or stature of cubs produced. Likewise, 10 of 12 denned polar bears tolerated exposure to exceptional levels of activity. This tolerance and the fact that investment in the denning effort increases through the winter indicated that spatial and temporal restrictions on developments could prevent the potential for many disruptions of denned bears from being realized. 16 refs., 1 fig., 2 tabs

Den medicinal-industrielle logik

DEFF Research Database (Denmark)

Børsen, Tom

2008-01-01

Et kig på medicinalindustrien og den logik der styrer udviklingen af nye lægemidler. Antagelsen er, at der også eksisterer et medicinalindustrielt kompleks, bestående af ledende industrifolk, læger, forskere og regeringsembedsmænd, der alle har kommercielle interesser i den herskende lægemiddeltæ...

Den sociale stofmisbrugsbehandling. Del 1

DEFF Research Database (Denmark)

Heltberg, Therese

Denne rapport er den første delrapport i en undersøgelse af den sociale stofmisbrugsbehandling i Danmark, som SFI har gennemført for Servicestyrelsen i perioden december 2007 til maj 2009. Undersøgelsen omhandler den sociale stofmisbrugsbehandling efter § 101 i Serviceloven, mens undersøgelsen i ...

Den positive psykologis metoder

DEFF Research Database (Denmark)

Andersen, Frans Ørsted; Mørck, Line Lerche; Nissen, Poul Erik

En antologi der giver en introduktion til en række af de metoder der anvendes til forskning, assessment, test, udviklingsarbejde og intervention indenfor den positive psykologi.......En antologi der giver en introduktion til en række af de metoder der anvendes til forskning, assessment, test, udviklingsarbejde og intervention indenfor den positive psykologi....

Den svage tænkning

DEFF Research Database (Denmark)

Dehs, Jørgen

1994-01-01

Interview med Gianni Vattimos. Italiensk politisk kultur, forholdet mellem politikeren og den intelektuelle og Gianni Vattimos program.......Interview med Gianni Vattimos. Italiensk politisk kultur, forholdet mellem politikeren og den intelektuelle og Gianni Vattimos program....

[Von den Restgütern zu den Sowchosen in Estland 1939-1953. Dokumentensammlung] / Olev Liivik

Index Scriptorium Estoniae

Liivik, Olev, 1975-

2011-01-01

Arvustus: Von den Restgütern zu den Sowchosen in Estland 1939-1953 : Dokumentensammlung / Hrsg. von David Feest, Karsten Brüggemann. Berlin : Lit Verlag, 2010. (Schriften der Baltischen historischen Kommission ; Bd. 15)

Da den moderne jazz kom til Danmark

DEFF Research Database (Denmark)

Høyer, Ole Izard; Nielsen, Anders H.U.

som tog over, deriblandt Erik Moseholm, Bent Axen og Jørn Elniff. Denne bog forklarer, hvordan den moderne jazz kom til Danmark, og hvordan den udviklede det danske jazzmiljø. Den inddrager faktorer som udenlandske musikeres besøg, koncerter og efterfølgende jazzsessions. Hvilken betydning havde disse...... for den danske jazzudvikling? Hvor blev musikken spillet, og hvordan blev den behandlet af medierne og af samfundet? Sammen med beskrivelser af de vigtigste moderne jazzmusikere fra perioden, analyseres og beskrives en række indspilninger af moderne dansk jazz for at undersøge hvornår, og hvilke af de nye...

Den guddommelige æstetik

DEFF Research Database (Denmark)

Moutamid, Mina El

2007-01-01

I denne artikel anlægges to perspektiver på det æstetiske i et forsøg på at identificere et forhold mellem det æstetiske og det religiøse. Med udgangspunkt i en fænomenologisk karakteristik af den religiøse oplevelse påvises en række lighedspunkter med den æstetiske oplevelse. Desuden defineres d...

Den Blå Drage

DEFF Research Database (Denmark)

Ingerslev, Gitte Holten

Denne publikation i serien Læselyst tjener tre formål. Den evaluerer læseprojektet Den blå drage i efteråret 2004 på Byskolen i Svendborg ? et projekt ledet af forfatteren Josefine Ottesen. Desuden gøres der rede for nogle af de teorier der støtter og begrunder arbejdsmåde og resultater i projektet...

Dorte Nors "Den store tomat"

DEFF Research Database (Denmark)

Michelsen, Jimmi

2017-01-01

Tekstgennemgang og undervisningsforløb til Dorte Nors "Den store tomat". Undervisningsforløbet er henvendt til elever i folkeskolens udskoling......Tekstgennemgang og undervisningsforløb til Dorte Nors "Den store tomat". Undervisningsforløbet er henvendt til elever i folkeskolens udskoling...

Remote identification of maternal polar bear (Ursus maritimus) denning habitat on the Colville River Delta, Alaska

Science.gov (United States)

Blank, Justin J.

High resolution digital aerial photographs (1 foot pixel size) of the Colville River Delta, Alaska were examined in 3D, with the use of a digital photogrammetric workstation. Topographic features meeting the criteria required for adequate snow accumulation, and subsequent construction of terrestrial polar bear maternal dens, were identified and digitized into an ArcGIS line shapefile. Effectiveness, efficiency, and accuracy were improved when compared to previous polar bear denning habitat efforts which utilized contact photo prints and a pocket stereoscope in other geographic areas of northern Alaska. Accuracy of photograph interpretation was systematically evaluated visually from the air with the use of a helicopter and physically on the ground. Results show that the mapping efforts were successful in identifying den habitat 91.3% of the time. Knowledge denning habitat can improve and inform decision making by managers and regulators when considering travel and development in the study area. An understanding of polar bear denning habitat extent and location will be a crucial tool for planning activities within the study area in a way that minimizes conflicts with maternal dens.

Luftstaub über den Meeren

DEFF Research Database (Denmark)

Kacunko, Slavko; Kacunko, Sabine; Gorbushina, Ana

2013-01-01

Staub umgibt uns überall und alles wird auch irgendwann zu Staub - ob wir wollen oder nicht. Staub nicht nur zu bekämpfen, sondern zu untersuchen, bildet den Ausgangspunkt zahlreicher Forschungen in den Natur-, Ingenieur- und Kulturwissenschaften. Der vorliegende Band verbindet solche Beiträge au...

Denning of grizzly bears in the Yellowstone National Park area

Science.gov (United States)

Judd, Steven L.; Knight, Richard R.; Blanchard, Bonnie M.

1986-01-01

Radiotelemetry was used to locate 101 grizzly bear (Ursus arctos) dens from 1975 to 1980; 35 dens were examined on the ground. Pregnant females denned in late October, and most other bears denned by mid-November. Duration of denning average 113, 132, and 170 days for males, females, and females with new cubs, respectively. Males emerged from mid-February to late March, followed by single females and females with yearlings and 2-year-olds. Females with new cubs emerged from early mid-April. Den sites were associated with moderate tree cover (26%-75% canopy cover) on 30°-60° slopes. Dens occurred on all aspects, although northerly exposures were most common. Grizzly bears usually dug new dens but occasionally used natural cavities or a den from a previous year. Males usually dug larger dens than females with young. Eight excavated and 2 natural dens of the 35 examined dens were used for more than 1 year.

The Dens: Normal Development, Developmental Variants and Anomalies, and Traumatic Injuries

Directory of Open Access Journals (Sweden)

William T O′Brien

2015-01-01

Full Text Available Accurate interpretation of cervical spine imagining can be challenging, especially in children and the elderly. The biomechanics of the developing pediatric spine and age-related degenerative changes predispose these patient populations to injuries centered at the craniocervical junction. In addition, congenital anomalies are common in this region, especially those associated with the axis/dens, due to its complexity in terms of development compared to other vertebral levels. The most common congenital variations of the dens include the os odontoideum and a persistent ossiculum terminale. At times, it is necessary to distinguish normal development, developmental variants, and developmental anomalies from traumatic injuries in the setting of acute traumatic injury. Key imaging features are useful to differentiate between traumatic fractures and normal or variant anatomy acutely; however, the radiologist must first have a basic understanding of the spectrum of normal developmental anatomy and its anatomic variations in order to make an accurate assessment. This review article attempts to provide the basic framework required for accurate interpretation of cervical spine imaging with a focus on the dens, specifically covering the normal development and ossification of the dens, common congenital variants and their various imaging appearances, fracture classifications, imaging appearances, and treatment options.

Hyldest til den destruktive feminist

DEFF Research Database (Denmark)

Hansen, Brian Benjamin

2017-01-01

Den destruktive feminist er kommet for at uddele røvfulde og slikkepinde – og hun er netop løbet tør for slikkepinde.......Den destruktive feminist er kommet for at uddele røvfulde og slikkepinde – og hun er netop løbet tør for slikkepinde....

American black bear denning behavior: Observations and applications using remote photography

Science.gov (United States)

Bridges, A.S.; Fox, J.A.; Olfenbuttel, C.; Vaughan, M.B.

2004-01-01

Researchers examining American black bear (Ursus americanus) denning behavior have relied primarily on den-site visitation and radiotelemetry to gather data. Repeated den-site visits are time-intensive and may disturb denning bears, possibly causing den abandonment, whereas radiotelemetry is sufficient only to provide gross data on den emergence. We used remote cameras to examine black bear denning behavior in the Allegheny Mountains of western Virginia during March-May 2003. We deployed cameras at 10 den sites and used 137 pictures of black bears. Adult female black bears exhibited greater extra-den activity than we expected prior to final den emergence, which occurred between April 12 and May 6, 2003. Our technique provided more accurate den-emergence estimation than previously published methodologies. Additionally, we observed seldom-documented behaviors associated with den exits and estimated cub age at den emergence. Remote cameras can provide unique insights into denning ecology, and we describe their potential application to reproductive, survival, and behavioral research.

Konservatismen og den højreradikale terror

DEFF Research Database (Denmark)

Skov, Christian Houlberg

2011-01-01

Den norske højreekstremist Anders Behring Breiviks terror mod det norske samfund har herhjemme ledt til en voldsom debat om blandt andet forbindelsen mellem tonen i debatten og terrorangrebet og forholdet mellem den siden 2001 meget omtalte kulturkonservatisme og Anders Breiviks terrorhandling....... Essayet Konservatismen og den højreradikale terror forsøger dels at skabe klarhed over fronterne i debatten, dels at rette en kritik mod såvel tendensen til at afskrive handlingen som uforståelig som af tendensen til at slå den bredere højrefløjs kritik af multikulturalismen i hartkorn med Breiviks...

'Den danske model' som tema

DEFF Research Database (Denmark)

Caraker, Emmett; Juul, Ida; Klindt, Mads Peter

2012-01-01

Tidsskrift for Arbejdsliv vol. 14, nr. 2, 5-8. Tema: 'Den danske model'. Redigeret af Emmett Caraker, Ida Juul, Mads peter Klindt & Jens Lind. 2011. København. 128 s.......Tidsskrift for Arbejdsliv vol. 14, nr. 2, 5-8. Tema: 'Den danske model'. Redigeret af Emmett Caraker, Ida Juul, Mads peter Klindt & Jens Lind. 2011. København. 128 s....

Den tabte fortælling

DEFF Research Database (Denmark)

Jørgensen, Kenneth Mølbjerg

2008-01-01

Ledelse er et af nøgleordene i fornyelsen af den offentlige sektor. Vi har imidlertid glemt et væsentligt aspekt af ledelse. Dette skyldes ikke mindst, at omgangsformen i dag er reguleret af information, mens den tidligere var reguleret af fortælleevnen. Evnen til dialog, indlevelse og nærvær er...

Den udenlandske udtales finurligheder

DEFF Research Database (Denmark)

Davidsen-Nielsen, Niels

2017-01-01

Eftertanken. Det er ikke altid nemt at tale om store, internationale kunstnere som Mozart eller Gabriel García Márquez. For hvordan skal den danske mund udtale z'et i Mozart og lægge trykket i García?......Eftertanken. Det er ikke altid nemt at tale om store, internationale kunstnere som Mozart eller Gabriel García Márquez. For hvordan skal den danske mund udtale z'et i Mozart og lægge trykket i García?...

Catalogue of polar bear (Ursus maritimus) maternal den locations in the Beaufort Sea and neighboring regions, Alaska, 1910-2010

Science.gov (United States)

Durner, George M.; Fischbach, Anthony S.; Amstrup, Steven C.; Douglas, David C.

2010-01-01

This report presents data on the approximate locations and methods of discovery of 392 polar bear (Ursus maritimus) maternal dens found in the Beaufort Sea and neighboring regions between 1910 and 2010 that are archived by the U.S. Geological Survey, Alaska Science Center, Anchorage, Alaska. A description of data collection methods, biases associated with collection method, primary time periods, and spatial resolution are provided. Polar bears in the Beaufort Sea and nearby regions den on both the sea ice and on land. Standardized VHF surveys and satellite radio telemetry data provide a general understanding of where polar bears have denned in this region over the past 3 decades. Den observations made during other research activities and anecdotal reports from other government agencies, coastal residents, and industry personnel also are reported. Data on past polar bear maternal den locations are provided to inform the public and to provide information for natural resource agencies in planning activities to avoid or minimize interference with polar bear maternity dens.

Den tidslogiske analyse af determinismeproblemet

DEFF Research Database (Denmark)

Øhrstrøm, Peter

2010-01-01

Artiklen diskuterer den filosofiske tidslogik med særligt henblik på A.N. Priors bidrag hertil. Det logiske determinismeproblem benyttes som gennemgående eksempel. Det vises endvidere, hvordan tidslogikken kan udnyttes til at analysere de logisk mulige positioner i en videnskabelig eller videnska...... videnskabsteoretisk debat. Her bruges den videnskabshistorisk betydende diskussion mellem Charles Darwin og Asa Gray som eksempel....

Ensretning i den internationale skatteret

DEFF Research Database (Denmark)

Schmidt, Peter Koerver; Bundgaard, Jakob

2015-01-01

I lyset af den seneste tids begivenheder (herunder særligt Luxleaks-sagerne) og tiltag på den internationale skattescene ses der i artiklen nærmere på en række af de forhold, som trækker i retning af øget ensretning af selskabsskattereglerne i store dele af verden. Det gøres gældende, at staternes...

Events i den globale bykonkurrence

DEFF Research Database (Denmark)

Østergaard, Katrine

2005-01-01

Paper til ph.d. workshop, d. 9. december 2005. Dette paper beskriver, hvorfor og hvordan events kan bruges som strategi for byplanlægning og byudvikling i den globale bykonkurrence.......Paper til ph.d. workshop, d. 9. december 2005. Dette paper beskriver, hvorfor og hvordan events kan bruges som strategi for byplanlægning og byudvikling i den globale bykonkurrence....

Kosmetisk kirurgi og den transformérbare krop -en analyse af den amerikanske tv-serie Nip/Tuck

DEFF Research Database (Denmark)

Jerslev, Anne

2009-01-01

En analyse af krops- og kønsiscenesættelser i den amerikanske tv-serie om kosmetisk kirurgi Nip/Tuck......En analyse af krops- og kønsiscenesættelser i den amerikanske tv-serie om kosmetisk kirurgi Nip/Tuck...

Grizzly bear denning chronology and movements in the Greater Yellowstone Ecosystem

Science.gov (United States)

Haroldson, Mark A.; Ternent, Mark A.; Gunther, Kerry A.; Schwartz, Charles C.

2002-01-01

Den entrance and emergence dates of grizzly bears (Ursus arctos) in the Greater Yellowstone Ecosystem are important to management agencies that wish to minimize impacts of human activities on bears. Current estimates for grizzly bear denning events use data that were collected from 1975–80. We update these estimates by including data obtained from 1981–99. We used aerial telemetry data to estimate week of den entry and emergence by determining the midpoint between the last known active date and the first known date denned, as well as the last known date denned and the first known active date. We also investigated post emergence movement patterns relative to den locations. Mean earliest and latest week of den entry and emergence were also determined. Den entry for females began during the fourth week in September, with 90% denned by the fourth week of November. Earliest den entry for males occurred during the second week of October, with 90% denned by the second week of December. Mean week of den entry for known pregnant females was earlier than males. Earliest week of den entry for known pregnant females was earlier than other females and males. Earliest den emergence for males occurred during the first week of February, with 90% of males out of dens by the fourth week of April. Earliest den emergence for females occurred during the third week of March; by the first week of May, 90% of females had emerged. Male bears emerged from dens earlier than females. Denning period differed among classes and averaged 171 days for females that emerged from dens with cubs, 151 days for other females, and 131 days for males. Known pregnant females tended to den at higher elevations and, following emergence, remained at higher elevation until late May. Females with cubs remained relatively close (grizzly bear populations in the southern Rocky Mountains. 

Nyliberalisme, universiteter og den akademiske frihed

DEFF Research Database (Denmark)

Madsen, Mogens Ove

2012-01-01

Akademisk frihed er uløseligt forbundet med det, der er selve universitetets væsen. New Public Management er dog sevet ind i den offentlige forvaltning og kapitlet giver et signalement af, hvilke konsekvenser dette har haft for universiteterne og den akademiske frihed...

Dens evaginatus and dens invaginatus in a double tooth: A rare case report

Directory of Open Access Journals (Sweden)

Gaurav Sharma

2015-01-01

Full Text Available The presence of dens invaginatus (DI and dens evaginatus (DE on same tooth is a rare phenomenon. However, when these dental anomalies occur on a double tooth, it becomes an extremely rare phenomenon. The authors report a rare case of DI and DE on fused permanent maxillary central incisor with supernumerary tooth in a 40-year-old male. The present article also focuses on the differentiating fusion from gemination and also reviews preventive and management strategies for tooth with complex dental anatomy.

koncernbegrebet og tilbudspligtens indtræden

DEFF Research Database (Denmark)

Clausen, Nis Jul; sørensen, karsten engsig

2010-01-01

  Med den nye selskabslov og de hertil knyttede ændringer i værdipapirhandelslovens regler om tilbudspligt har man fastholdt ønsket om parallelitet mellem det selskabsretlige koncernbegreb og kriterierne for tilbudspligtens indtræden. Det drøftes, om koncernbegrebet reelt er overført til tilbudsp...

Ueber die arten und den Skelettbau von Culcita

NARCIS (Netherlands)

Hartlaub, Clemens

1892-01-01

Das Genus Culcita Agass. zählt durch die merkwürdige Form und die ansehnliche Grösse seiner Arten zu den interessantesten Asteriden, und gut conservirte Exemplare davon gehören zu den Zierden unsrer Museen. Um so bedauerlicher erschien es mir, als ich vor einiger Zeit den Versuch machte die von

Fødens festival

DEFF Research Database (Denmark)

Agerholm, Frank Juul

2012-01-01

Som den italienske antropolog og folklorist Alessandro Falassi gør opmærksom på i antologien Time out of Time: Essays on the Festival, så er det sparsomt, hvad der er gjort af teoretiske forsøg på definere, hvad en festival er. Det står altså skidt til med et begreb om festivalen, og dette endog...... til trods for, at der er forsket i festivalen som fænomen siden det 19. århundrede – tilmed inden for en række forskellige faglige discipliner såsom religionsvidenskab, sociologi, antropologi, folklore m.fl. Endnu mere sparsomt må det vel så også stå til med bud på, hvad fødens festival er for en...

Filosofisk terapi som træning til døden

DEFF Research Database (Denmark)

Dræby, Anders

Den eksistentielfænomenologiske terapi deler den opfattelse med stoicismen, at filosofiens hovedopgave er at hjælpe mennesket med at finde vej i en problematisk verden. Oplægget udforsker desuden et overlap, som består i den indsigt, at terapeutisk udfrielse fra menneskelig lidelse til livsduelig......Den eksistentielfænomenologiske terapi deler den opfattelse med stoicismen, at filosofiens hovedopgave er at hjælpe mennesket med at finde vej i en problematisk verden. Oplægget udforsker desuden et overlap, som består i den indsigt, at terapeutisk udfrielse fra menneskelig lidelse til...

Den kontraktstyrede og kontraktstyrende offentlige sektor

DEFF Research Database (Denmark)

Schulze, Christiane; Greve, Carsten

Kontraktbaseret styring har været på den politiske agenda i OECD landene siden de tidlige 1980’erne og i dag er kontrakter et helt centralt element i den moderne regering ((Ejersbo & Greve 2005: 62, Greve 2008a: 4). Internationalt var det især med Reagon-regeringen i USA og Thatcher-regeringen i...... den private sektor og [som] brug af markedsmekanismer”(Greve 2003). Ved siden af privatisering og deregulering iagttages kontrakter som et determinerende element i NPM (Fortin 2000:1). Kontrakter kan helt grundlæggende defineres som en aftale mellem bestiller og leverandør, der angiver vilkårene...

Immunological pathogenesis of inflammatory bowel disease

Directory of Open Access Journals (Sweden)

Seung Hoon Lee

2018-01-01

Full Text Available Inflammatory bowel disease (IBD is a chronic inflammatory state of the gastrointestinal tract and can be classified into 2 main clinical phenomena: Crohn's disease (CD and ulcerative colitis (UC. The pathogenesis of IBD, including CD and UC, involves the presence of pathogenic factors such as abnormal gut microbiota, immune response dysregulation, environmental changes, and gene variants. Although many investigations have tried to identify novel pathogenic factors associated with IBD that are related to environmental, genetic, microbial, and immune response factors, a full understanding of IBD pathogenesis is unclear. Thus, IBD treatment is far from optimal, and patient outcomes can be unsatisfactory. As result of massive studying on IBD, T helper 17 (Th17 cells and innate lymphoid cells (ILCs are investigated on their effects on IBD. A recent study of the plasticity of Th17 cells focused primarily on colitis. ILCs also emerging as novel cell family, which play a role in the pathogenesis of IBD. IBD immunopathogenesis is key to understanding the causes of IBD and can lead to the development of IBD therapies. The aim of this review is to explain the pathogenesis of IBD, with a focus on immunological factors and therapies.

Christian Birch - den korrupte konferensråd

DEFF Research Database (Denmark)

Jensen, Mette Frisk

2005-01-01

  http://www.sidensaxo.dk/fileadmin/saxo-abstract-uploads/christian_birch_den_korrupte_konferensraad_2005_3.pdf......  http://www.sidensaxo.dk/fileadmin/saxo-abstract-uploads/christian_birch_den_korrupte_konferensraad_2005_3.pdf...

Denning behaviour of non-gravid wolves, Canis lupus

Science.gov (United States)

Mech, L.D.; Phillips, M.K.; Smith, D.W.; Kreeger, T.J.

1996-01-01

Wild wolves (Canis lupus) that had produced pups in earlier years but were not currently pregnant, and ovariectomized captive wolves, dug dens during and after the whelping season even though they produced no pups. These observations suggest that den digging is not a function of pregnancy or of ovarian estrogen or progesterone. We hypothesize that increasing prolactin in spring elicits or mediates den-digging behavior.

Selection of den sites by black bears in the southern Appalachians

Science.gov (United States)

Reynolds-Hogland, M. J.; Mitchell, M.S.; Powell, R.A.; Brown, D.C.

2007-01-01

We evaluated selection of den sites by American black bears (Ursus americanus) in the Pisgah Bear Sanctuary, western North Carolina, by comparing characteristics of dens at 53 den sites with availability of habitat characteristics in annual home ranges of bears and in the study area. We also tested whether den-site selection differed by sex, age, and reproductive status of bears. In addition, we evaluated whether the den component of an existing habitat model for black bears predicted where bears would select den sites. We found bears selected den sites far from gravel roads, on steep slopes, and at high elevations relative to what was available in both annual home ranges and in the study area. Den-site selection did not differ by sex or age, but it differed by reproductive status. Adult females with cubs preferred to den in areas that were relatively far from gravel roads, but adult females without cubs did not. The habitat model overestimated the value of areas near gravel roads, underestimated the value of moderately steep areas, and did not include elevation as a predictor variable. Our results highlight the importance of evaluating den selection in terms of both use and availability of den characteristics. ?? 2007 American Society of Mammalogists.

Mozart, Karl Barth, og den kristne troslæren

DEFF Research Database (Denmark)

Petersen, Nils Holger

2010-01-01

En diskussion af Karl Barths teologiske brug af W.A.Mozart i den kirchliche Dogmatik med kontekstuel inddragelse af en til en vis grad tilsvarende overordnet diskussion af Mozart, skrevet af en samtidig musiker, den fremtrædende Mozart-dirigent Ferenc Fricsay. ......En diskussion af Karl Barths teologiske brug af W.A.Mozart i den kirchliche Dogmatik med kontekstuel inddragelse af en til en vis grad tilsvarende overordnet diskussion af Mozart, skrevet af en samtidig musiker, den fremtrædende Mozart-dirigent Ferenc Fricsay. ...

Transnational organisatorisk innovation i den offentlige sektor

DEFF Research Database (Denmark)

Hansen, Morten Balle

2013-01-01

Artiklen undersøger tre problemstillinger: 1) Hvor udbredt er forskellige former for transnational organisatorisk innovation i den danske offentlige sektor? 2) Hvordan er disse organisatoriske innovationer relateret til hinanden? 3) Er forskelle i deres udbredelse relateret til forskelle mellem den...... forskelle og ligheder mellem statslige og kommunale organisationer. 11 former for organisatorisk innovation, hvoraf mange ofte forbindes med New Public Management (NPM), er inkluderet i de empiriske analyser: privatisering/udlicitering, Bestiller-Udfører-model, kontraktstyring, mål- og rammestyring...... innovationer. Forskellige fortolkninger af den større udbredelse i kommuner end i stat drøftes....

Denver District Laboratory (DEN)

Data.gov (United States)

Federal Laboratory Consortium — Program CapabilitiesDEN-DO Laboratory is a multi-functional laboratory capable of analyzing most chemical analytes and pathogenic/non-pathogenic microorganisms found...

Samarbejdets betydning i den ’klassiske udlicitering’

DEFF Research Database (Denmark)

Lindholst, Andrej Christian

2015-01-01

Hvilken betydning har ’samarbejde’ i kontraktstyringen mellem offentlige myndigheder og private entreprenører inden for de ’klassiske’ udbudsområder? I både den administrative praksis og den politologiske litteratur betragtes en effektiv anvendelse af udlicitering på de klassiske udbudsområder of...

Den professionelle rolle

DEFF Research Database (Denmark)

Præstegaard, Jeanette; Sørensen, Kirsten

2009-01-01

Psykiatri er den disciplin indenfor lægevidenskaben, der beskæftiger sig med at forebygge, diagnosticere og helbrede psykiske sygdomme. I “Lærebog i psykiatri” giver Lene Nyboe sig bud på ergoterapeutisk og fysioterapeutisk kernefaglighed indenfor det psykiatriske område. Behandlingstraditionerne...

Advances in understanding gray matter pathology in multiple sclerosis: Are we ready to redefine disease pathogenesis?

Directory of Open Access Journals (Sweden)

Zivadinov Robert

2012-03-01

Full Text Available Abstract The purpose of this special issue in BMC Neurology is to summarize advances in our understanding of the pathological, immunological, imaging and clinical concepts of gray matter (GM pathology in patients with multiple sclerosis (MS. Review articles by Lucchinetti and Popescu, Walker and colleagues, Hulst and colleagues and Horakova and colleagues summarize important recent advances in understanding GM damage and its implications to MS pathogenesis. They also raise a number of important new questions and outline comprehensive approaches to addressing those questions in years to come. In the last decade, the use of immunohistochemistry staining methods and more advanced imaging techniques to detect GM lesions, like double inversion recovery, contributed to a surge of studies related to cortical and subcortical GM pathology in MS. It is becoming more apparent from recent biopsy studies that subpial cortical lesions in early MS are highly inflammatory. The mechanisms responsible for triggering meningeal inflammation in MS patients are not yet elucidated, and they should be further investigated in relation to their role in initiating and perpetuating the disease process. Determining the role of antigens, environmental and genetic factors in the pathogenesis of GM involvement in MS is critical. The early involvement of cortical and subcortical GM damage in MS is very intriguing and needs to be further studied. As established in numerous cross-sectional and longitudinal studies, GM damage is a better predictor of physical disability and cognitive impairment than WM damage. Monitoring the evolution of GM damage is becoming an important marker in predicting future disease course and response to therapy in MS patients.

Konsulenten i den anden nat

DEFF Research Database (Denmark)

Kirkegaard, Line

for i sit deres liv og den eksistensmåde, der hermed muliggøres. Med dette ønsker jeg at bidrage til de eksisterende work-life balance teorier. Min vej ind i teorierne er nemlig, at logikken i mit empiriske materiale forekommer så forskelligt fra de traditionelle work-life balance teorier, at disse ikke...... lader sig forene. Jeg foretage derfor en analyse af den eksisterende litteratur, og rejser i den forbindelse en grundlæggende kritik af work-life balance teorierne, for at operere med falske problemstillinger på en måde, så svaret allerede indgår i de spørgsmål, der stilles. Jeg argumenterer således for......, at det problematiske forhold ved work-life balance teorierne allerede skal søges i konstitueringen af deres problematik, hvor arbejde og fritid indgår som to distinkte og kontrasterende sfærer. Ubalance eller problemer søges således altid i relationen her imellem. I forlængelse heraf argumenterer jeg for...

Leadership pipeline i den offentlige sektor

DEFF Research Database (Denmark)

Dahl, Kristian Aagaard; Molly-Søholm, Thorkil

en rejse ind i hjertet af offentlig ledelse med fokus på lederniveauerne: topchef, funktionel chef, leder af ledere og leder af medarbejdere. Med afsæt i righoldige eksempler og fortællinger fra virkeligheden introduceres læseren for ledelsesteorien den Offentlige Leadership Pipeline, som giver...... enkelte lederniveauer og udvikle ledertalenter. Teorien byder på et detaljeret ledelsesgrundlag, hvorudfra den offentlige organisation kan bygge en professionel værdikæde for ledelse ved at forme lederprofiler, -rekruttering, -uddannelse, -evaluering m.m. Leadership Pipeline i den offentlige sektor er...... baseret på et treårigt dansk praksisorienteret forskningsprojekt med deltagelse af 15 offentlige organisationer, som repræsenterer kommunerne, regionerne og staten. Projektet har videreudviklet en af de sidste 10 års mest indflydelsesrige ledelseteorier i de største private organisationer, Leadership...

Cornelis den Hartog: an outstanding aquatic ecologist

NARCIS (Netherlands)

Velde, van der G.; Brock, T.C.M.; Kempers, A.J.

1996-01-01

A survey is given of the work and life of Cornelis den Hartog up to the date in 1996 on which he retired from his position as a professor at the University of Nijmegen. Cornelis (Kees) den Hartog made important contributions to aquatic ecology in the widest sense, e.G. On brackish water typology,

Den danske regionskonstruktion

DEFF Research Database (Denmark)

Klausen, Kurt Klaudi; Christoffersen, Henrik

Region Midtjylland er i centrum for analysen men den omfatter også regionsdannelsen i almindelighed. Der anlægges i analysen på samme tid et politologisk, organisationsteoretisk og økonomisk resonnement. Regionsdannelsen finder sted på baggrund af de setup Strukturreformen har sat, men udfoldes p...

Empirisme, rationalisme og den moralske følelse

DEFF Research Database (Denmark)

Nielsen, Carsten Fogh

2003-01-01

Sammenlignende diskussion af David Humes og Immanuel Kants syn på følelsernes rolle for den moralske dom......Sammenlignende diskussion af David Humes og Immanuel Kants syn på følelsernes rolle for den moralske dom...

Den farefulde gyngeleg

DEFF Research Database (Denmark)

Karoff, Helle Skovbjerg

2014-01-01

I lyset af samtidens diskussioner af sikkerhed og det farefulde (Sandseter, 2009) i børns fysiske leg skal artiklen udforske forholdet mellem den interaktive gynge SON-X, legeaktiviteterne og det farefulde. Formålet er at undersøge, hvordan børn håndterer det farefulde og sikkerhed i deres gyngeleg......, og det formål skal udforskes gennem stemningsperspektivet (Karoff, 2010, 2013). Stemningsperspektivet er et livsfilosofisk perspektiv på legeaktiviteterne (Schiller, 1996, Nietzsche, 1996, Huizinga, 1956, Gadamer, 1966), der anskuer legeaktiviteterne som praksis, der har til formål at sætte de...... deltagende i en særlig stemning. En stemning er en måde at være til på i verden, der præges af åbenhed over for øjeblikket, over for andre mennesker og over for nye muligheder for at skabe mening (Heidegger, 2005). Afslutningsvist skal artiklen reflektere over teknologiens rolle – eksemplificeret med den...

Skønhed og rædsel i den nye Pharma Science Building

DEFF Research Database (Denmark)

Reeh, Henrik

2016-01-01

Reportage fra et fælles besøg i den nyligt indviede PharmaScience Building, Københavns Universitet, juni 2016. Teksten om mødet mellem journalist og forsker på den ene side og bygningen og dens brugere på den anden side. Journalist Christoffer Zieler henviser til Henrik Reehs separat offentliggjo......Reportage fra et fælles besøg i den nyligt indviede PharmaScience Building, Københavns Universitet, juni 2016. Teksten om mødet mellem journalist og forsker på den ene side og bygningen og dens brugere på den anden side. Journalist Christoffer Zieler henviser til Henrik Reehs separat...

Den skjulte Oldtid – den nye udstilling på Nationalmuseet

DEFF Research Database (Denmark)

Ingemann, Bruno

2009-01-01

Enhver udstilling konstruerer sin besøgende! Man skal som besøgende have bestemte forudsætninger, en vis viden, kende bestemte kategorier, have en bestemt form for nysgerrighed – og det er udstillingen som skaber dette særsprog med dets muligheder for at udelukke eller inkludere den besøgende. De...

Den kaotiske organisation

DEFF Research Database (Denmark)

Helms, Niels Henrik

2006-01-01

Præsentation af den britiske organisationsteoretiker Ralph Stacey: Stacey mener samlet, at organisationer ikke skal ses som systemer, der opstår, når individer interagerer med hinanden. Det er selve interaktionen, der er organisationen. Staceys kernebegreb er temporære processer. Når vi interager...

Diana og Kirke. Den klassiske mytes metamorfose i italienske Renæssance

DEFF Research Database (Denmark)

Cecchini, Leonardo

Den klassiske myte har en særlig stilling i det, Aleida Assmann har kaldt kulturelle Gedächtnis. Takket være dens store udbredelse i den vestlige kultur (både i litteratur, kunst og i andre områder), har den en tendens til at virke, snarere end som konkret ”tekst”, som et udbredt kulturel registe...... renæssancekulturen omarbejder den klassiske myte. Som case-stories vil jeg anvende Kirke-myten og ”den mytiske jagt” (Diana og Aktæon) og vise, hvordan de bliver genanvendt, tilpasset og fortolket i tekster af Petrarca, Boccaccio, Machiavelli og Gelli....

Dwellers in dens on sandy bottoms: Ecological and behavioural traits of Octopus vulgaris

Directory of Open Access Journals (Sweden)

Ángel Guerra

2014-09-01

Full Text Available Four visual censuses targeting Octopus vulgaris living in dens on sandy bottoms were carried out from June to October 2013 in the National Park of the Atlantic Galician Islands (NW Spain. Censuses were undertaken by scuba diving between 5 and 21 m depth in daytime. The total area swept was 13.75 ha. There were no significant differences between octopus presence in dens during open and closed fishing seasons. Depth had a significant negative relationship with occupancy. The average number of dens per 1000 m2 was 3.84±0.84 in June and 3.89 in October. The area per den was 260 m2. Den number estimations varied between 1586 and 2057. The largest number of dens (76.5% was found between 5 and 10 m depth. Den distribution was clumped. No significant differences were found between octopus size classes (small, medium and large and den diameter. Associate dens were observed. There were no significant differences in den diameter and shell types found around the middens. Many dens could be “permanent”. Drilling bivalve shell behaviour is discussed. The surveyed area had around 1100 individuals, mainly small specimens. No significant differences were found between octopus size and depth. Substrate, den type and food abundance and availability (especially razors Ensis arcuatus seem to be the main factors influencing dens and octopus density and distribution. Den availability does not appear to be a limiting factor in this case. Temperature, den availability, predators and fishing pressure influencing density and distribution are discussed. Rodas inlet may be a preferential habitat for O. vulgaris individuals ranging from 200 to 2000 g, but especially small specimens ( ≤ 1000 g.

Trump, NATO og den europæiske sikkerhedsarkitektur

DEFF Research Database (Denmark)

Ringsmose, Jens; Henriksen, Anders

Manglende klarhed i den amerikanske linje over for det NATO, landet indtil nu har taget føringen i, vil få konsekvenser for Europa og for Danmarks muligheder og valg. Denne rapport ser på konsekvenserne for den europæiske sikkerhedsarkitektur....

Mod en ny forståelse af den digitaliseringsstrategiske proces

DEFF Research Database (Denmark)

Ivang, Reimer

2007-01-01

Den digitale teknologi er vigtig, og vigtigheden kan ikke kun afspejles i den konstant stigende mængde af litteratur, der relaterer sig til fænomenet. Men vigtigheden er også identificeret på Danfoss, der er afhandlingens empiriske kontekst. Der synes at være enighed om, at den digitale teknologi...

Den koreanske bølgen - En kulturvitenskapelig studie av sørkoreansk populærkultur, og hvordan den har nådd Vesten

OpenAIRE

Kvinge, Kristin Øyvindsdatter

2016-01-01

Hensikten med denne oppgaven er å se på den koreanske bølgen, som ofte refereres til som Hallyu. Den tar for seg både Hallyu som innhold og Hallyu som fenomen. Den koreanske bølgen har spredd seg hurtig i løpet av de siste 20 årene, noe som har bidratt til å gjøre Korea til en av de hurtigst økende økonomiene i den moderne tid. Denne oppgaven forsøker å se nærmere på hvordan Hallyu har nådd Vesten, med fokus på Europa og Norge. Før analysen vil oppgaven se nærmere på hv...

[Identification of Dens Draconis and Os Draconis by XRD method].

Science.gov (United States)

Chen, Guang-Yun; Wu, Qi-Nan; Shen, Bei; Chen, Rong

2012-04-01

To establish an XRD method for evaluating the quality of Os Draconis and Dens Draconis and applying in judgement of the counterfeit. Dens Draconis, Os Draconis and the counterfeit of Os Draconis were analyzed by XRD. Their diffraction patterns were clustered analysis and evaluated their similarity degree. Established the analytical method of Dens Draconis and Os Draconis basing the features fingerprint information of the 10 common peaks by XRD pattern. Obtained the XRD pattern of the counterfeit of Os Draconis. The similarity degree of separate sources of Dens Draconis was high,while the similarity degree of separate sources of Os Draconis was significant different from each other. This method can be used for identification and evaluation of Os Draconis and Dens Draconis. It also can be used for identification the counterfeit of Os Draconis effectively.

I den sidste time

DEFF Research Database (Denmark)

Norup, Lis

: Dekadencens teori. Arthur William Symons: Dekadencens litteratur. Oscar Wilde: Kritikeren som kunstner) Noter I tekster skrevet i 1800-tallet udfoldes dekadencekunsten som den forfinede sensibilitets, de forstyrrede sansers og det oprevne sinds digtning. Med litteraturhenvisninger....

Digital kommunikation med den offentlige sektor

DEFF Research Database (Denmark)

Berger, Jesper; Andersen, Kim Normann

2013-01-01

Denne rapport sammenfatter hovedresultaterne af en undersøgelse gennemført i juni måned 2013 om besvarelse af e-mail og digital post i den statslige, regionale og kommunale sektor. Allerede med eDag3 1. nov. 2010 skulle alle myndigheder have oprettet en digital postkasse, som borgerne kunne skrive...... til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs. uden at uvedkommende kan få adgang til...... følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Undersøgelsen medtager myndighedernes besvarelse af digital post og e-mail, dels for at kunne...

Digital kommunikation med den offentlige sektor

DEFF Research Database (Denmark)

Berger, Jesper Bull; Andersen, Kim Normann

Denne rapport sammenfatter hovedresultaterne for styrelser og statslige organisationer af en undersøgelse gennemført i sommeren 2013 om besvarelse af e-mail og digital post i den statslige, regionale og kommunale sektor. Allerede med eDag3 1. nov. 2010 skulle alle myndigheder have oprettet en...... digital postkasse, som borgerne kunne skrive til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs....... uden at uvedkommende kan få adgang til følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Vi har også undersøgt besvarelse af e-mail, dels...

Asymptomatic ''crowned dens'' calcification in CT images for the craniovertebral junction

International Nuclear Information System (INIS)

Kubota, Gen; Mori, Masataka; Fukushima, Tatsuro

2007-01-01

Calcification around the odontoid process suggests 'crowned dens' syndrome, when accompanied with acute occipital headache or neck pain and with inflammatory signs. We retrospectively searched for calcification around the odontoid process in routine CT images of 282 patients emcompassing the craniovertebral junction, and found 13 (4.6%) had 'crowned dens' calcifications with neither characteristic symptoms nor signs suggestive for crowned dens' syndrome. Females of older ages frequently showed asymptomatic crowned dens' calcifications. (author)

"Den lille havfrue" som digital pop op-bog

DEFF Research Database (Denmark)

Mygind, Sarah

2017-01-01

Anmeldelse af: DIGITAL POP OP-BOG H. C. ANDERSEN OG BOOKS & MAGIC DEN LILLE HAVFRUE Bog og App til iOS & Android 5......Anmeldelse af: DIGITAL POP OP-BOG H. C. ANDERSEN OG BOOKS & MAGIC DEN LILLE HAVFRUE Bog og App til iOS & Android 5...

Trichomonas vaginalis Pathogenesis: a Narrative Review

Directory of Open Access Journals (Sweden)

Zahra Arab-Mazar

2015-07-01

Full Text Available In the latest articles which were published during 2013-2014, Trichomonas vaginalis (T. vaginalis was mentioned as a neglected sexual transmission disease (STD, while the exact mechanism of its pathogenesis has not been cleared yet. Although trichomonasiasis is easy curable, there is concern that resistance to drug are increasing. This common infection as concerning the important public health implications needs more research to be done for understanding the diagnosis, treatment, immunology and pathogenesis. In this review we searched all valuable and relevant information considering the pathogenesis of T. vaginalis. We referred to the information databases of Medline, PubMed, Scopus and Google scholar. The used keywords were the combinations of T. vaginalis and words associated with pathogenicity. This review discusses the host-parasite interaction and pathogenicity of this parasite.

Premolarized double dens in dente in albinism - A case report

Directory of Open Access Journals (Sweden)

Suprabha B

2005-09-01

Full Text Available Dens in dente are known to be associated with many dental abnormalities such as taurodontism microdontia, gemination, and dens evaginatus. This paper describes a rare case of double dens in dente in a lateral incisor with crown morphology similar to a premolar present in a patient with features of albinism. Problems associated with this condition and their management is discussed.

Despotism and risk of infanticide influence grizzly bear den-site selection.

Science.gov (United States)

Libal, Nathan S; Belant, Jerrold L; Leopold, Bruce D; Wang, Guiming; Owen, Patricia A

2011-01-01

Given documented social dominance and intraspecific predation in bear populations, the ideal despotic distribution model and sex hypothesis of sexual segregation predict adult female grizzly bears (Ursus arctos) will avoid areas occupied by adult males to reduce risk of infanticide. Under ideal despotic distribution, juveniles should similarly avoid adult males to reduce predation risk. Den-site selection and use is an important component of grizzly bear ecology and may be influenced by multiple factors, including risk from conspecifics. To test the role of predation risk and the sex hypothesis of sexual segregation, we compared adult female (n = 142), adult male (n = 36), and juvenile (n = 35) den locations in Denali National Park and Preserve, Alaska, USA. We measured elevation, aspect, slope, and dominant land cover for each den site, and used maximum entropy modeling to determine which variables best predicted den sites. We identified the global model as the best-fitting model for adult female (area under curve (AUC) = 0.926) and elevation as the best predictive variable for adult male (AUC = 0.880) den sites. The model containing land cover and elevation best-predicted juvenile (AUC = 0.841) den sites. Adult females spatially segregated from adult males, with dens characterized by higher elevations (mean= 1,412 m, SE = 52) and steeper slopes (mean = 21.9°, SE = 1.1) than adult male (elevation: mean = 1,209 m, SE = 76; slope: mean = 15.6°, SE = 1.9) den sites. Juveniles used a broad range of landscape attributes but did not avoid adult male denning areas. Observed spatial segregation by adult females supports the sex hypothesis of sexual segregation and we suggest is a mechanism to reduce risk of infanticide. Den site selection of adult males is likely related to distribution of food resources during spring.

Den sundhedsvidenskabelige opgave

DEFF Research Database (Denmark)

Lindahl, Marianne Pia; Juhl, Carsten Bogh

troværdigheden af sine resultater. Bogen er opdateret, så den refererer til Microsoft Office 2013, og giver instruktioner og tips til: • Hvordan man bruger Word til hjælp med indholdsfortegnelse, overskrifter og korrektur • Hvordan man bruger Word til hjælp med diagrammer og tabeller• Hvordan man bruger Excel...

Den positive psykologis metoder

DEFF Research Database (Denmark)

Bogen introducerer til de mange metoder, som anvendes i positiv psykologi. dette sker ud fra en reflekteret tilgang, der ligeledes rummer bidrag fra kritisk psykologi med det formål at nuancere den positive psykologis forståelser...

Hepatitis E: Molecular Virology and Pathogenesis

Science.gov (United States)

Panda, Subrat K.; Varma, Satya P.K.

2013-01-01

Hepatitis E virus is a single, positive-sense, capped and poly A tailed RNA virus classified under the family Hepeviridae. Enteric transmission, acute self-limiting hepatitis, frequent epidemic and sporadic occurrence, high mortality in affected pregnants are hallmarks of hepatitis E infection. Lack of an efficient culture system and resulting reductionist approaches for the study of replication and pathogenesis of HEV made it to be a less understood agent. Early studies on animal models, sub-genomic expression of open reading frames (ORF) and infectious cDNA clones have helped in elucidating the genome organization, important stages in HEV replication and pathogenesis. The genome contains three ORF's and three untranslated regions (UTR). The 5′ distal ORF, ORF1 is translated by host ribosomes in a cap dependent manner to form the non-structural polyprotein including the viral replicase. HEV replicates via a negative-sense RNA intermediate which helps in the formation of the positive-sense genomic RNA and a single bi-cistronic sub-genomic RNA. The 3′ distal ORF's including the major structural protein pORF2 and the multifunctional host interacting protein pORF3 are translated from the sub-genomic RNA. Pathogenesis in HEV infections is not well articulated, and remains a concern due to the many aspects like host dependent and genotype specific variations. Animal HEV, zoonosis, chronicity in immunosuppressed patients, and rapid decompensation in affected chronic liver diseased patients warrants detailed investigation of the underlying pathogenesis. Recent advances about structure, entry, egress and functional characterization of ORF1 domains has furthered our understanding about HEV. This article is an effort to review our present understanding about molecular biology and pathogenesis of HEV. PMID:25755485

GMO-afgrøder ikke den eneste løsning

DEFF Research Database (Denmark)

Jacobsen, Niels; Jacobsen, Sven-Erik; Sørensen, Marten

2010-01-01

Er GMO-afgrøder den optimale løsning på klodens fremtidige plantebaserede fødevareproduktion? Findes der alternativer? Det er der to meget klare svar på:GMOafgrøderer ikke den eneste løsning, og ja, der findes mange og langt mere attraktive, bæredygtige løsninger......Er GMO-afgrøder den optimale løsning på klodens fremtidige plantebaserede fødevareproduktion? Findes der alternativer? Det er der to meget klare svar på:GMOafgrøderer ikke den eneste løsning, og ja, der findes mange og langt mere attraktive, bæredygtige løsninger...

Den skjulte religion

DEFF Research Database (Denmark)

Rubow, Cecilie

2001-01-01

Kulturbegrebet har længe været genstand for kritik i human- og samfundsvidenskaberne. Studier i Vesteuropa, blandt andet i det danske folkekirkelige felt, viser, at der er flere paralleller at drage til religionsbegrebet. Der er behov for at bevæge sig væk fra den rutineprægede beskrivelse og gøre...

Vrouekarakters in enkele prosawerke van C.M. van den Heever

Directory of Open Access Journals (Sweden)

E. Botha

2003-08-01

Full Text Available The role of women in some prose works of C.M. van den Heever Re-reading the C.M. van den Heever “classics” Somer (1935 and Laat vrugte (1939 within the framework of Van den Heever criticism through the years, one becomes aware that central themes in his oeuvre are acted out by women. The beautiful young girl Linda in Somer embodies the sadness of the transcience of beauty and happiness. Through Ouma Willa, Betta and Johanna – three women from three generations in Laat vrugte – the theme of the endurance of the memory of love and passion beyond decay and death is expressed. A cursory examination of other and earlier works by Van den Heever – Op die plaas (1927, Langs die grootpad (1928, Kromburg (1937 and the short story “Leuens” (Lies from Vuurvlieg en sterre (1934 – bears out the observation that women express core meanings in C.M. van den Heever’s prose works.

Understanding the genetic and molecular pathogenesis of Friedreich’s ataxia through animal and cellular models

Science.gov (United States)

Martelli, Alain; Napierala, Marek; Puccio, Hélène

2012-01-01

In 1996, a link was identified between Friedreich’s ataxia (FRDA), the most common inherited ataxia in men, and alterations in the gene encoding frataxin (FXN). Initial studies revealed that the disease is caused by a unique, most frequently biallelic, expansion of the GAA sequence in intron 1 of FXN. Since the identification of this link, there has been tremendous progress in understanding frataxin function and the mechanism of FRDA pathology, as well as in developing diagnostics and therapeutic approaches for the disease. These advances were the subject of the 4th International Friedreich’s Ataxia Conference held on 5th–7th May in the Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France. More than 200 scientists gathered from all over the world to present the results of research spanning all areas of investigation into FRDA (including clinical aspects, FRDA pathogenesis, genetics and epigenetics of the disease, development of new models of FRDA, and drug discovery). This review provides an update on the understanding of frataxin function, developments of animal and cellular models of the disease, and recent advances in trying to uncover potential molecules for therapy. PMID:22382366

Vildsvin uønsket i den danske natur

DEFF Research Database (Denmark)

Andersen, Camilla Brasch; Bald, Caroline; Uttenthal, Åse

2011-01-01

Vildsvin ønskes fortsat ikke etableret i den danske natur, da de udgør en smitterisiko for husdyr og mennesker. det er helt essentielt for bekæmpelsen, at lodsejere og jægere deltager aktivt. de skal lokalisere de vildsvin, der allerede findes i den danske natur, og nedlægge dem....

Skaber den nye økonomi højere produktivitet?

DEFF Research Database (Denmark)

Dilling-Hansen, Mogens; Madsen, Erik Strøjer; Smith, Valdemar

2001-01-01

Den kraftige og vedvarende vækst i USA og det tilhørende boom i IT-sektoren er grundlaget for begrebet 'Den nye Økonomi', der er dukket op i sidste halvdel af 90'erne. Den grundlæggende sammenhæng mellem de to fænomener er, at IT-industrien i sig selv og produktivitetsstigninger i de øvrige branc......-sektoren i servicesektoren, der har haft store produktivitetsstigninger. Det gælder også for telekommunikationssektoren, medens der blandt IT-konsulentvirksomheder lidt overraskende ikke kan påvises tilsvarende produktivitetsstigninger....

Den europæiske sukkersektor - efter reformerne

DEFF Research Database (Denmark)

Hansen, Henning Otte

2017-01-01

Med reformerne af EU’s sukkerpolitik ændredes vilkårene for hele den europæiske sukkersektor. Resultatet ses nu i form af stærkere struktur- og produktivitetsudvikling og dermed en stigende international konkurrenceevne.......Med reformerne af EU’s sukkerpolitik ændredes vilkårene for hele den europæiske sukkersektor. Resultatet ses nu i form af stærkere struktur- og produktivitetsudvikling og dermed en stigende international konkurrenceevne....

Dansk udlevering efter den europæiske arrestordre

DEFF Research Database (Denmark)

Elholm, Thomas; Bang Fuglsang Madsen Sørensen, Henning

2016-01-01

Den europæiske arrestordre, der blev vedtaget af EU i 2002, har haft stor betydning for retsudviklingen vedrørende udlevering af personer til strafforfølgning eller strafafsoning i EU. Danmark er - trods retsforbeholdet - fuldt ud med i ordningen om arrestordren, og mange danske domstole har...... efterhånden haft sådanne sager. Det har givet anledning til en række vanskelige juridiske spørgsmål. I den sidste tid har det især drejet sig om, hvorvidt udlevering kan afslås med henvisning til urimelige fængselsforhold i andre lande. EU-domstolen har den 5. april 2016 afsagt en vigtig dom om spørgsmålet...

Den Dansk-Engelske Regnskabsordbog/Danish-English Dictionary of Accounting

DEFF Research Database (Denmark)

Nielsen, Sandro; Mourier, Lise; Bergenholtz, Henning

Den Dansk-Engelske Regnskabsordbog. Hver af ordbøgerne har 4.100 opslagsord og ca. 15.000 ordforbindelser. Ordbøgerne bygger primært på den gældende danske årsregnskabslov, danske regnskabsvejledninger og internationale regnskabsstandarder (IAS/IFRS)....

Despotism and risk of infanticide influence grizzly bear den-site selection.

Directory of Open Access Journals (Sweden)

Nathan S Libal

Full Text Available Given documented social dominance and intraspecific predation in bear populations, the ideal despotic distribution model and sex hypothesis of sexual segregation predict adult female grizzly bears (Ursus arctos will avoid areas occupied by adult males to reduce risk of infanticide. Under ideal despotic distribution, juveniles should similarly avoid adult males to reduce predation risk. Den-site selection and use is an important component of grizzly bear ecology and may be influenced by multiple factors, including risk from conspecifics. To test the role of predation risk and the sex hypothesis of sexual segregation, we compared adult female (n = 142, adult male (n = 36, and juvenile (n = 35 den locations in Denali National Park and Preserve, Alaska, USA. We measured elevation, aspect, slope, and dominant land cover for each den site, and used maximum entropy modeling to determine which variables best predicted den sites. We identified the global model as the best-fitting model for adult female (area under curve (AUC = 0.926 and elevation as the best predictive variable for adult male (AUC = 0.880 den sites. The model containing land cover and elevation best-predicted juvenile (AUC = 0.841 den sites. Adult females spatially segregated from adult males, with dens characterized by higher elevations (mean= 1,412 m, SE = 52 and steeper slopes (mean = 21.9°, SE = 1.1 than adult male (elevation: mean = 1,209 m, SE = 76; slope: mean = 15.6°, SE = 1.9 den sites. Juveniles used a broad range of landscape attributes but did not avoid adult male denning areas. Observed spatial segregation by adult females supports the sex hypothesis of sexual segregation and we suggest is a mechanism to reduce risk of infanticide. Den site selection of adult males is likely related to distribution of food resources during spring.

Stephen Schwartz og den folkelige lyd

DEFF Research Database (Denmark)

Kreutzfeldt, Jacob

2013-01-01

Stephen Schwartz døde i foråret 2013. I denne artikel forsøger Jacob Kreutzfeldt, der gennemførte en række interviews med Schwartz gennem hans sidste år, at indkredse den æstetiske grundholdning, der prægede hans arbejde med radiomontagen i DR.......Stephen Schwartz døde i foråret 2013. I denne artikel forsøger Jacob Kreutzfeldt, der gennemførte en række interviews med Schwartz gennem hans sidste år, at indkredse den æstetiske grundholdning, der prægede hans arbejde med radiomontagen i DR....

Den empiriske uddannelsesvidenskab og kvalitet i studieaktivitet

DEFF Research Database (Denmark)

Keiding, Tina Bering; Qvortrup, Ane

2015-01-01

Bidraget kobler studieaktivitetesmodellen med kvalitetsindikatorer for god undervisning, og viler blandt andet, hvorledes modellen kan støtte samtænkning af forskellige undervisnings- og læringsformater med henblik på øge den aktive læretid......Bidraget kobler studieaktivitetesmodellen med kvalitetsindikatorer for god undervisning, og viler blandt andet, hvorledes modellen kan støtte samtænkning af forskellige undervisnings- og læringsformater med henblik på øge den aktive læretid...

Philipp van den Bossche – Sac. Caes. Mai. Phrygiarius

Czech Academy of Sciences Publication Activity Database

Bukovinská, Beket

-, č. 0130 (2015), s. 1-18 ISSN 2190-3328 Institutional support: RVO:68378033 Keywords : Philipp van den Bossche * Prague court * Rudolph II * Kunstkammer Subject RIV: AL - Art, Architecture, Cultural Heritage http://www.riha-journal.org/articles/2015/2015-oct-dec/bukovinska-philipp-van-den-bossche

Malaysia. Kan den politiske fred fortsætte?

DEFF Research Database (Denmark)

Fleming, Daniel; Søborg, Henrik

2008-01-01

Der er valg i det muslimske Malaysia den 8. marts 2008. Et land med klar etnisk opdeling, men også med stor politisk stabilitet. Hvordan hænger det sammen?......Der er valg i det muslimske Malaysia den 8. marts 2008. Et land med klar etnisk opdeling, men også med stor politisk stabilitet. Hvordan hænger det sammen?...

Klimagasudledning i kæden fra foder- til mælkeproduktion

DEFF Research Database (Denmark)

Mogensen, Lisbeth; Lund, Peter; Kristensen, Troels

2012-01-01

Når man skal vurdere effekten af forskellige tiltag til reduktion af klimagasudledningen, f.eks. via ændret fodersammensætning, er det vigtigt at se på den samlede effekt i hele kæden. Ellers kan man mindske udledning et sted i kæden og øge udledningen et andet sted, og samlet set ikke opnå en...

Vidensledelse og den sociale dimension i deling af viden

DEFF Research Database (Denmark)

Lauring, Jakob

2004-01-01

imidlertid et alternativt syn på viden som i højere grad inddrager den sociale dimension ved vidensdeling - den socialkonstruktivistiske opfattelse. I denne artikel vil jeg beskæftige mig med den socialkonstruktivistiske opfattelse af viden og beskrive, hvorledes denne synsvinkel kan rette fokus mod nogle...... meget væsentlige problemstillinger ved organisatorisk adfærd, som man ofte kommer til at ignorere, hvis man i for høj grad baserer ledelsen på en funktionalistisk opfattelse af viden. Delingen af viden er en aktuel udfordring for anvendelse af viden i forretningssammenhæng. Det er hovedsageligt det, som...... gør vidensbegrebet interessant i forhold til ledelse af virksomheder. - Fokus på de sociale barrierer for deling af viden Jeg vil i det kommende illustrere, hvilke betydninger den sociale dimension i deling af viden kan have for videnledelse. Det vil jeg gøre gennem beskrivelser af to forskellige...

Datenschutz in den sozialen Medien aus privatrechtlicher Perspektive

Directory of Open Access Journals (Sweden)

Hager, Johannes

2017-12-01

Full Text Available Der Datenschutz in den sozialen Medien wirft eine Reihe von Problemen auf. Zum einen geht es um das Verhältnis des Datenschutzgesetzes zum Persönlichkeitsrecht; hier wird sich eine Kombinationslehre wie bei sonstigen besonderen Persönlichkeitsrechten – etwa dem Bildnisschutz – als überlegen erweisen. Die §§ 7 ff dTMG privilegieren die Provider in mehrfacher Hinsicht. Freilich bleibt deren Haftung oft unberührt. So kann der Content-Provider zur Verantwortung gezogen werden auch wenn er sich fremde Nachrichten nur zu eigen macht. Der Host-Provider haftet ab Kenntnis des rechtswidrigen Inhalts; auch treffen ihn eine Reihe von Prüfungspflichten. Entgegen der Auffassung des BGH ist er auch verpflichtet, den Namen des Content-Providers zu nennen. Schließlich kommt eine Haftung des Access-Providers in Betracht, wenn er die rechtswidrigen Inhalte wissentlich weiterleitet. Entgegen der Auffassung des EuGH besteht ein Gerichtsstand überall dort, wo sich die unerlaubte Handlung – die Verletzung des Persönlichkeitsrechts – verwirklicht; sie ist nicht auf den Tatort und den Ort beschränkt, an dem sich das Opfer befindet.

Uddrag af Ph.d.-afhandlingen Den groteske modernisme

DEFF Research Database (Denmark)

Lübker, Henrik

2011-01-01

Om forholdet mellem "det groteske" og "den groteske modernisme" eksemplificeret i en læsning af E.A. Poes "The Fall of the House of Usher" og flere af Francis Bacons malerier.......Om forholdet mellem "det groteske" og "den groteske modernisme" eksemplificeret i en læsning af E.A. Poes "The Fall of the House of Usher" og flere af Francis Bacons malerier....

'Welzijnsvloer verdient zich op den duur terug'; van den Berg beproeft de groene vlag roostervloer

NARCIS (Netherlands)

Anoniem,

2010-01-01

Het onderzoek van Wageningen UR naar de welzijnsvloeren is nog in volle gang. Maar vleeskalverhouder Wijnand van den Berg uit Kootwijkerbroek heeft op eigen initiatief al een welzijnsrooster in zijn stal op proef

Læringsfremmende evaluering i den lægelige videreuddannelse

DEFF Research Database (Denmark)

Madsen, Bjørn; Klitmøller, Anders

2011-01-01

Denne statusartikel omhandler evaluering af læger, og hvorledes evaluering kan anvendes som en læringsfremmende foranstaltning. Fokus i artiklen er på den formelle evaluering, som den kommer til udtryk i de kliniske vejledersamtaler. Da de fleste læger i deres karriere fungerer som vejleder, er d...

Den postmoderne konstruktivismes inkongruenser

DEFF Research Database (Denmark)

Cristoffanini, Pablo Rolando

2011-01-01

europæiske intellektuelle og akademikere gjorde teorierne og ideerne om underudvikling og afhængighed, der stammede fra Latinamerika, til deres egne. Også i den sidste tid har latinamerikanske intellektuelle, som fx Nestor García Canclini, haft indflydelse i Europa og USA med sin teori om hybriditet og...

Helicobacter pylori virulence and cancer pathogenesis.

Science.gov (United States)

Yamaoka, Yoshio; Graham, David Y

2014-06-01

Helicobacter pylori is human gastric pathogen that causes chronic and progressive gastric mucosal inflammation and is responsible for the gastric inflammation-associated diseases, gastric cancer and peptic ulcer disease. Specific outcomes reflect the interplay between host-, environmental- and bacterial-specific factors. Progress in understanding putative virulence factors in disease pathogenesis has been limited and many false leads have consumed scarce resources. Few in vitro-in vivo correlations or translational applications have proved clinically relevant. Reported virulence factor-related outcomes reflect differences in relative risk of disease rather than specificity for any specific outcome. Studies of individual virulence factor associations have provided conflicting results. Since virulence factors are linked, studies of groups of putative virulence factors are needed to provide clinically useful information. Here, the authors discuss the progress made in understanding the role of H. pylori virulence factors CagA, vacuolating cytotoxin, OipA and DupA in disease pathogenesis and provide suggestions for future studies.

Den moderne bevidstheds katedral

DEFF Research Database (Denmark)

Ostenfeld Pedersen, Simon

2002-01-01

Interview med idéhistorikeren Dorthe Jørgensen der under overskriften ”Den moderne bevidstheds katedral” blotlægger hendes mangeårige arbejde med Hegel, og hvor hun giver en række relevante bud på en aktualiserende Hegel-læsning centreret omkring felter som metafysik, historiefilosofi og æstetik....

Das Bild behinderter Menschen in den Medien

OpenAIRE

Radtke, Peter

2006-01-01

„Das Bild von Behinderung und behinderten Menschen in den Medien“ - dieses Thema führt sehr leicht zur Schwarz-Weiß-Malerei. Bekanntlich fällt es schwer, es allen recht zu machen. So nimmt es nicht Wunder, dass sich Betroffene und ihre Angehörigen in den Medien sowohl quantitativ als auch qualitativ oftmals nicht angemessen repräsentiert fühlen. [...] In dieser Situation bilden die Medien die wichtigste und oft einzige Informationsquelle über das Leben und die Möglichkeiten von Menschen mit e...

Laika – den første hund i rummet

DEFF Research Database (Denmark)

Alstrup, Aage Kristian Olsen

2013-01-01

DETTE ER DEN FØRSTE ARTIKEL I EN SERIE OM FORSØGSDYRENES ROLLE I RUMFORSKNINGEN. DYRENE SPILLEDE EN CENTRAL ROLLE I RUSSERNES OG AMERIKANERNES RUMKAPLØB UNDER DEN KOLDE KRIG. I DAG BRUGES DYRENE TIL MEDICINSKE FORSØG UDFØRT I VÆGTLØS TILSTAND. FØRSTE ARTIKEL HANDLER OM GADEKRYDSET LAIKA, SOM BLEV...

Forårets konflikter godt for den danske model

DEFF Research Database (Denmark)

Scheuer, Steen

2008-01-01

Den store vinder ved forårets konflikter var den danske model for aftaler på arbejdsmarkedet. De offentlige fagforeninger fik sig en lærestreg, da regeringen og Folketinget til de flestes overraskelse lod de lovlige konflikter løbe i ugevis. For hermed tvang man parterne, og især forbundene, til...

Ueber den begriff "Kinoplasma" in der spermiogenese von Australorbis Glabratus Olivaceus (Mollusca, Pulmonata, Planorbidae

Directory of Open Access Journals (Sweden)

Rudolf Barth

1960-11-01

Full Text Available Zur Klaerung der Frage, ob der Begriff "Kinoplasma" fuer gewisse, von MERTON (1924,1926, 1930 beobachtete Bildungen an den reifenden Spermiden von pulmonaten Mollusken oder fuer Bestandteile des Cytoplasmas im Sinne von STRASBURGER und SCARTH zu verwenden ist, werden in der vorliegenden Mitteilung die Vorgaenge bei der Spermiohistogenese von Australorbis glabratus olivaceus untersucht. Es ergibt sich: 1. Das von MERTON bezeichnete "Kinoplasma" existiert nicht als solches, es handelt sich bei den von ihm dargestellten Protoplasmabildungen um kugelige, von den Spermiden abgeschnuerte Restkoerper nicht verwendeten Baumaterials, bestehend aus Protoplasma und einigen Mitochondrien. Sie werden von den Naehr- oder Bazalzellen phagozytiert. Der Ausdruck "Kinoplasma" kann nur fuer die submikroskopischen, geformten, faedigen Elemente des Cytoplasmas reserviert bleiben, die den geradlinigen Fall der uebrigen nicht geformten Komponenten bremst oder ablenkt; damit muss das Kinoplasma aber aus dem Begriff des Cytoplasmas herausgenommen werden, da es, wenn auch vermutlich reversibel, eine Differenzierung darstellt. 2. Der Spermienfaden wird von den Centriolen (Axialfilament und den Mitochondrien (zwei peripher gelegene Spiralfilamente, sowie einem Plasmamantel gebildet. 3. Nach Beendigung des Auswachsens der Spermiengeissel, die zu diesem Zeitpunkt nur aus dem Achsenfaden und dem Protoplasmazylinder besteht, setzt sich eine Protoplasmamasse vom Kopf in Richtung zum Geisselende in Bewegung. Sie fuehrt den Golgi-Koerper und sehr viele Mitochondrien mit sich. Aus diesen entwickeln sich Fibrillen, die sich zu den beiden Spiralfilamenten zusammenfuegen. Diese Masse entspricht der von MERTON in seiner Theorie als Kinoplasma bezeichneten Komponente. 4. Die Bewegung dieses Protoplasmateils wird auf den Schub zurueckgefuehrt, den die sich bildenden Fibrillen auf die Mitochondrien ausueben. 5. Die Rueckwaertsbewegung dieses Protoplasmakoerpers beruht wahrscheinlich auf

Den amoralske liberalisme

DEFF Research Database (Denmark)

Skov, Christian Houlberg

2011-01-01

Fra både højre og venstre skydes der i disse år med skarpt mod liberalismen; i denne artikel anmelder Christian H. Skov Against Liberalism af John Kekes, der søger at påvise liberalismens mangler fra et logisk-filosofisk udgangspunkt, med den grundlæggende påstand, at liberalismens to mål, at fre......, at fremelske autonomi og begrænse ondskab, er uforenelige....

Døden og morderen

DEFF Research Database (Denmark)

Hansen, Kim Toft

2014-01-01

forskellige versioner af Forbrydelsen: DR's oprindelige udgave, AMC's udgave The Killing og David Hewsons roman Forbrydelsen, der er baseret på manuskriptet til DR-serien. Grundfortællingen under disse tre versioner relaterer jeg til H.C. Andersens "Historien om en Moder" og tilskrivningen af mening til døden....

Synteserapport & 1. Indenrigspolitiske forhold i Den Islamiske Republik Iran

DEFF Research Database (Denmark)

Pedersen, Claus Valling

Rapport til Udenrigsministeriet om de indenrigspolitiske forhold i Iran samt et syntese af hele rapporten: Iran som regional og international medspiller i den globale verdensorden samt Irans indenrigspolitik......Rapport til Udenrigsministeriet om de indenrigspolitiske forhold i Iran samt et syntese af hele rapporten: Iran som regional og international medspiller i den globale verdensorden samt Irans indenrigspolitik...

Den første Karl Gustav-krig 1657-58

DEFF Research Database (Denmark)

Olden-Jørgensen, Sebastian

2008-01-01

Artiklen diskuterer den første Karl Gustav-krig i forskellige persketiver og konkluderer, at krigen ikke bør opfattes som et dårligt forberedt og uigennemtænkt forsøg på dansk revanche inden for rammerne af en nordisk rivalisering, men snarere som  en velovervejet satsning og et led i den dansk-s...

Nye militære trends i den syriske borgerkrig

DEFF Research Database (Denmark)

Engen, Torben Toftgaard; Kjellund, Jon

2018-01-01

I den flerårige syriske borgerkrig har der fundet tre nye militære trends sted, der peger imod, at fremtidens landmilitære kampplads vil være væsensforskellig fra indsatserne i Irak og Afghanistan. Denne rapport analyserer de tre trends inden for digitaliseringen af den hybride krigsførelse og ka...

Simultaneous Occurrence of Dens Invaginatus and Fusion

Directory of Open Access Journals (Sweden)

Amit Mhapuskar

2013-01-01

Full Text Available Although Dens invaginatus and fusion are well-known and well established dental anomalies, they are rarely seen in supernumerary teeth. In this article, simultaneous occurrence of Dens invaginatus and fusion between maxillary lateral incisor and a supernumerary tooth is described. Dens invaginatus is clinically significant due to the possibility of the pulpal involvement; pulpitis, necrotic pulps and chronic periapical lesions are often associated with this anomaly without clinical symptoms. Fusion has a negative impact on the aesthetics, especially when it occurs in maxillary anterior teeth. It is difficult to clinically make differential diagnosis between fused teeth and geminated teeth, especially when these anomalies take place together with hypodontia or supernumerary tooth. It has been found that sequel of such teeth may result in delayed eruption, ectopic eruption or even impaction of permanent teeth; hence proper diagnosis by clinical and radiographic methods and intervention at appropriate time is of paramount importance. The accurate knowledge of variations in morphology of tooth and pulp cavity greatly assists the dentist in planning successful treatment options.

Epigenetics and colorectal cancer pathogenesis.

Science.gov (United States)

Bardhan, Kankana; Liu, Kebin

2013-06-05

Colorectal cancer (CRC) develops through a multistage process that results from the progressive accumulation of genetic mutations, and frequently as a result of mutations in the Wnt signaling pathway. However, it has become evident over the past two decades that epigenetic alterations of the chromatin, particularly the chromatin components in the promoter regions of tumor suppressors and oncogenes, play key roles in CRC pathogenesis. Epigenetic regulation is organized at multiple levels, involving primarily DNA methylation and selective histone modifications in cancer cells. Assessment of the CRC epigenome has revealed that virtually all CRCs have aberrantly methylated genes and that the average CRC methylome has thousands of abnormally methylated genes. Although relatively less is known about the patterns of specific histone modifications in CRC, selective histone modifications and resultant chromatin conformation have been shown to act, in concert with DNA methylation, to regulate gene expression to mediate CRC pathogenesis. Moreover, it is now clear that not only DNA methylation but also histone modifications are reversible processes. The increased understanding of epigenetic regulation of gene expression in the context of CRC pathogenesis has led to development of epigenetic biomarkers for CRC diagnosis and epigenetic drugs for CRC therapy.

Epigenetics and Colorectal Cancer Pathogenesis

International Nuclear Information System (INIS)

Bardhan, Kankana; Liu, Kebin

2013-01-01

Colorectal cancer (CRC) develops through a multistage process that results from the progressive accumulation of genetic mutations, and frequently as a result of mutations in the Wnt signaling pathway. However, it has become evident over the past two decades that epigenetic alterations of the chromatin, particularly the chromatin components in the promoter regions of tumor suppressors and oncogenes, play key roles in CRC pathogenesis. Epigenetic regulation is organized at multiple levels, involving primarily DNA methylation and selective histone modifications in cancer cells. Assessment of the CRC epigenome has revealed that virtually all CRCs have aberrantly methylated genes and that the average CRC methylome has thousands of abnormally methylated genes. Although relatively less is known about the patterns of specific histone modifications in CRC, selective histone modifications and resultant chromatin conformation have been shown to act, in concert with DNA methylation, to regulate gene expression to mediate CRC pathogenesis. Moreover, it is now clear that not only DNA methylation but also histone modifications are reversible processes. The increased understanding of epigenetic regulation of gene expression in the context of CRC pathogenesis has led to development of epigenetic biomarkers for CRC diagnosis and epigenetic drugs for CRC therapy

Epigenetics and Colorectal Cancer Pathogenesis

Directory of Open Access Journals (Sweden)

Kebin Liu

2013-06-01

Full Text Available Colorectal cancer (CRC develops through a multistage process that results from the progressive accumulation of genetic mutations, and frequently as a result of mutations in the Wnt signaling pathway. However, it has become evident over the past two decades that epigenetic alterations of the chromatin, particularly the chromatin components in the promoter regions of tumor suppressors and oncogenes, play key roles in CRC pathogenesis. Epigenetic regulation is organized at multiple levels, involving primarily DNA methylation and selective histone modifications in cancer cells. Assessment of the CRC epigenome has revealed that virtually all CRCs have aberrantly methylated genes and that the average CRC methylome has thousands of abnormally methylated genes. Although relatively less is known about the patterns of specific histone modifications in CRC, selective histone modifications and resultant chromatin conformation have been shown to act, in concert with DNA methylation, to regulate gene expression to mediate CRC pathogenesis. Moreover, it is now clear that not only DNA methylation but also histone modifications are reversible processes. The increased understanding of epigenetic regulation of gene expression in the context of CRC pathogenesis has led to development of epigenetic biomarkers for CRC diagnosis and epigenetic drugs for CRC therapy.

Epigenetics and Colorectal Cancer Pathogenesis

Energy Technology Data Exchange (ETDEWEB)

Bardhan, Kankana; Liu, Kebin, E-mail: Kliu@gru.edu [Department of Biochemistry and Molecular Biology, Medical College of Georgia, and Cancer Center, Georgia Regents University, Augusta, GA 30912 (United States)

2013-06-05

Colorectal cancer (CRC) develops through a multistage process that results from the progressive accumulation of genetic mutations, and frequently as a result of mutations in the Wnt signaling pathway. However, it has become evident over the past two decades that epigenetic alterations of the chromatin, particularly the chromatin components in the promoter regions of tumor suppressors and oncogenes, play key roles in CRC pathogenesis. Epigenetic regulation is organized at multiple levels, involving primarily DNA methylation and selective histone modifications in cancer cells. Assessment of the CRC epigenome has revealed that virtually all CRCs have aberrantly methylated genes and that the average CRC methylome has thousands of abnormally methylated genes. Although relatively less is known about the patterns of specific histone modifications in CRC, selective histone modifications and resultant chromatin conformation have been shown to act, in concert with DNA methylation, to regulate gene expression to mediate CRC pathogenesis. Moreover, it is now clear that not only DNA methylation but also histone modifications are reversible processes. The increased understanding of epigenetic regulation of gene expression in the context of CRC pathogenesis has led to development of epigenetic biomarkers for CRC diagnosis and epigenetic drugs for CRC therapy.

Den danske stat og det naturlige fædreland

DEFF Research Database (Denmark)

Glenthøj, Rasmus

2007-01-01

forsøgte på engang at være loyale over for både det statsborgerlige fædreland, der inkluderede hele den danske stat, og deres naturlige fædreland Norge, som de følte sig forbundet til gennem deres nationalitet og opvækst. Danskerne opererede med den samme dualistiske fædrelandsopfattelse, hvor de både...

Update on mucormycosis pathogenesis.

Science.gov (United States)

Ibrahim, Ashraf S; Kontoyiannis, Dimitrios P

2013-12-01

Mucormycosis is an increasingly common fungal infection with unacceptably high mortality. The recent sequencing genome projects of Mucorales and the development of gene manipulation have enabled significant advances in understanding the pathogenesis of mucormycosis. Therefore, we review the pathogenesis of mucormycosis and highlight potential development of novel diagnostic and therapeutic modalities against this lethal disease. Much of the work has been focused on the role of iron uptake in the virulence of Mucorales. Additionally, host receptors and fungal ligands involved in the process of tissue invasion as well as sporangiospore size and sex loci and their contribution to virulence of Mucorales are discussed. Finally, the role of innate and adaptive immunity in protection against Mucorales and new evidence about drug-induced apoptosis in these fungi are discussed. Recent discoveries introduce several potentially novel diagnostic and therapeutic modalities, which are likely to improve management and outcome for mucormycosis. Future preclinical and clinical research is warranted to develop these diagnostic and therapeutic strategies.

Brand management og den refleksive forbruger - med semiotik som hjælpedisciplin

DEFF Research Database (Denmark)

Hermansen, Judy

2009-01-01

  Kritisk eftertanke er et væsentligt træk ved den refleksive forbruger - ofte parret med en vis negativitet overfor et brand, en reklame eller forbrugerisme i al almindelighed. Den refleksive forbrugertype kommer til udtryk hos for eksempel en anti-branding guru som Naomi Klein og hendes...... bestseller bog "No Logo" eller i græsrodsbevægelsen Adbusters ( https://www.adbusters.org/ ), der efterhånden i mange år har udsendt et månedsmagasin med kritik af forbrugersamfundet og al dets reklame og branding. Disse anti-forbrugs og anti-branding bevægelser udspringer af, og er identifikationspunkter...... - den refleksive forbruger skal have noget, der kan "brande" ham som anderledes end alle mainstreamforbrugerne. Den refleksive forbruger er med andre ord en Feinschmecker og i lighed med - eller måske rettere i endnu højere grad end - alle andre forbrugere signalerer den refleksive forbruger sin...

Børnebøger : Døden er en del af livet

DEFF Research Database (Denmark)

Petersen, Anne

2010-01-01

Der findes mange kvalitetsbøger, som giver børn en litterær hjælpende hånd til at håndtere de store eksistentielle spørgmål om døden, og som kan lette sorgen. Bøgerne er ofte lune og usentimentale, men kan være højtidelige. På den fine måde.......Der findes mange kvalitetsbøger, som giver børn en litterær hjælpende hånd til at håndtere de store eksistentielle spørgmål om døden, og som kan lette sorgen. Bøgerne er ofte lune og usentimentale, men kan være højtidelige. På den fine måde....

Vector competence of Aedes albopictus and Aedes aegypti (Diptera: Culicidae) for the DEN2-FJ10 and DEN2-FJ11 strains of the dengue 2 virus in Fujian, China.

Science.gov (United States)

Guo, Xiao-Xia; Li, Chun-Xiao; Zhang, Ying-Mei; Xing, Dan; Dong, Yan-De; Zhang, Heng-Duan; Qin, Cheng-Feng; Zhao, Tong-Yan

2016-09-01

Dengue is an acute, emerging, infectious disease transmitted by Aedes mosquitoes that has become a serious global public health problem. The DEN2-FJ10 and DEN2-FJ11 strains of the dengue 2 virus were originally isolated from the serum of a patient with dengue fever in Fujian Province, China, in 1999. Our data provide the first assessment of the vector competence of Aedes mosquitoes with respect to the DEN2-FJ10 and DEN2-FJ11 strains of the dengue virus. There were significant differences in the replication rates of these two viral strains in Aedes albopictus and Aedes aegypti (P0.05). In summary, our results indicate that Ae. albopictus and Ae. aegypti mosquitoes are moderately competent vectors of the DEN2-FJ10 and DEN2-FJ11 strains of the dengue virus and provide the first evidence of the effect of these two viral strains on the vector competence of mosquitoes in China. Copyright © 2016 Elsevier B.V. All rights reserved.

Den gamle verdens magi

DEFF Research Database (Denmark)

Holck, Jakob Povl

I denne bog præsenterer forskningsbibliotekar cand.mag., ph.d. Jakob Povl Holck sjældne bøger og andre biblioteksmaterialer fra Herlufsholm-samlingen på Syddansk Universitetsbibliotek i Odense. Bogens form udgør en mosaik af værker i tekst og især billeder med speciel vægt på ’den videnskabelige ...

Fox Den Disease: An Interesting Case Following Delayed Diagnosis.

Science.gov (United States)

Stehr, Ryan C; Kim, Nicholas; LoGiudice, John A; Ludwig, Kirk

2015-06-01

Pyoderma fistulans sinifica, also known as fox den disease, is a rare and poorly understood inflammatory disorder of the skin and subcutaneous tissues. This disorder is often mistaken for other inflammatory skin disorders and treated inappropriately. The authors describe the case of a 53-year-old male who presented to the colorectal surgery service with a longstanding diagnosis of perirectal Crohn's disease. Despite aggressive immunosuppression and numerous surgical procedures, the patient continued to have unrelenting purulent drainage from the skin of his buttocks. Following wide excision of the affected skin and subcutaneous tissues by the colorectal surgeon, the plastic surgery team reconstructed the 30 cm x 55 cm wound using a combination of local flaps and skin grafts. The initial pathology report of the excised specimen confirmed the presence of nonspecific abscesses and inflammation. Upon special request by the plastic surgery team, the sample was resectioned with the specific intent of establishing a diagnosis of fox den disease. The additional slides met the criteria for an unequivocal diagnosis of fox den disease. Immunosuppression was discontinued and the patient healed his wounds without complication. Fox den disease is often overlooked because of the obscurity of the disease and the special histological sectioning needed to establish a diagnosis. In this case, the patient was unnecessarily treated with immunosuppressive drugs for more than 3 decades because of a misdiagnosis. With increased awareness of fox den disease, perhaps its pathophysiology can be better elucidated as more patients are appropriately diagnosed and treated.

Endodontic, surgical and periodontal treatment of dens invaginatus. Case report.

Science.gov (United States)

Castellarin, M; Demitri, V; Politi, M

2001-01-01

The aim of this paper is to propose a single stage global treatment of endodontic, periapical and periodontal lesions in a lateral maxillary incisor with dens invaginatus. A 24 year-old woman presenting a lateral maxillary incisor with dens invaginatus in association with periapica1 and periodontal lesions underwent simultaneous surgical, endodontic and periodontal regenerative procedures. At 2, 6, 12, 18 months follow-up the radiographic healing appeared to be improved and the periapical lesion healed completely 1 year after surgical intervention. Surgery in association with endodontic and periodontal procedures represents the treatment of choice to maximize long term prognosis in cases of dens invaginatus with chronic periapical and periodontal lesions.

Chlorerede opløsningsmidler i den mættede zone

DEFF Research Database (Denmark)

Broholm, K.

1996-01-01

Anmeldelse af Jensen,B.K. & Nilsson,B.: Chlorerede opløsningsmidler i den mættede zone. Miljøstyrelsen 1996, (Miljøprojekt 330)......Anmeldelse af Jensen,B.K. & Nilsson,B.: Chlorerede opløsningsmidler i den mættede zone. Miljøstyrelsen 1996, (Miljøprojekt 330)...

Den skrøbelige sandhed

DEFF Research Database (Denmark)

Pedersen, Peter Ole

2010-01-01

Artiklen retter fokus mod de seneste års udvikling af den aktivistiske dokumentarfilm. Med analytiske punktnedslag hos instruktørerne Michael Moore, Morgan Spurlock, Dylan Avery, Robert Greenwald og Mauro Andrizzi undersøges de forbindelser der eksisterer mellem udtrykket i de populære spillefilm...

Den græske by i Afghanistan

DEFF Research Database (Denmark)

Hannestad, Lise

2016-01-01

Byen Ai Khanoum som blev udgravet i i 1960'erne i det nordøstlige Afghanistan blev grundlagt som følge af Alexander den Stores erobring af hele Nærorienten og frem til det nordlige Indien. Fundene viser en spændende blanding af græsk og nræorientalsk kultur......Byen Ai Khanoum som blev udgravet i i 1960'erne i det nordøstlige Afghanistan blev grundlagt som følge af Alexander den Stores erobring af hele Nærorienten og frem til det nordlige Indien. Fundene viser en spændende blanding af græsk og nræorientalsk kultur...

Dragons' Den: promoting healthcare research and innovation.

Science.gov (United States)

Mazhindu, Deborah; Gregory, Siobhan

2015-07-01

The changing health and social care landscape, and, in particular, the financial challenges affecting the NHS, can present difficulties for staff looking for funding to support innovation and new ways of working. One method of competitive tendering that is becoming more accepted as a way of allocating funds, encouraging staff engagement and developing innovation for research is a format based the BBC television series, Dragons' Den. This article describes how Hounslow and Richmond Community Healthcare NHS Trust, London, has developed a 'Dragons' Den initiative' of annual competitive research funding allocation to ensure that some of the most dynamic practice in the trust is captured.

[Current concepts in pathogenesis of age-related macular degeneration].

Science.gov (United States)

Kubicka-Trząska, Agnieszka; Karska-Basta, Izabella; Romanowska-Dixon, Bożena

2014-01-01

Age-related macular degeneration is the leading cause of central blindness in elderly population of the western world. The pathogenesis of this disease, likely multifactorial, is not well known, although a number of theories have been put forward, including oxidative stress, genetic interactions, hemodynamic imbalance, immune and inflammatory processes. The understanding of age-related macular degeneration pathogenesis will give rise to new approaches in prevention and treatment of the early and late stages of both atrophic and neovascular age-related macular degeneration.

Den europæiske drøm - om EU

DEFF Research Database (Denmark)

Østergaard, Uffe

2007-01-01

Anmeldelse af: Jeremy Rifkin: Den europæiske drøm (Informations Forlag, 2006). Oversat fra engelsk efter: "The European Dream: How Europe's Vision of the Future Is Quietly Eclipsing the American Dream" (2004)......Anmeldelse af: Jeremy Rifkin: Den europæiske drøm (Informations Forlag, 2006). Oversat fra engelsk efter: "The European Dream: How Europe's Vision of the Future Is Quietly Eclipsing the American Dream" (2004)...

Die polnischen Bücher (Bücherbestände in den Bibliotheken Roms. Eine Auswahl

Directory of Open Access Journals (Sweden)

Ligia ALeksandra Henczel-Wróblewska

2017-11-01

Full Text Available Die italienisch-polnischen Beziehungen haben eine lange Geschichte hinter sich. Seit dem Mittelalter, in dem die polnischen Scholaren ihre Ausbildung an den italienischen Universitäten genießen konnten, dominierte darin der wissenschaftliche und bildende Charakter. In den folgenden Jahrhunderten wurde der gegenseitige Kontakt um die künstlerische Ebene erweitert, zumal die polnischen Künstler nach Italien reisten, um bei den besten Meistern ihre Fertigkeiten zu vervollkommnen. Seit dem Ende des 18. bis zur Mitte des 19. Jahrhunderts kam zu den bereits bestehenden, tradierten italienischpolnischen Beziehungen im Bereich der Wissenschaft und Kultur der militärische und der sozialpolitische Aspekt hinzu, und mit der Zeit auch der wirtschaftliche. Auf dem italienischen Boden beteiligten sich die Polen zunächst an den Unabhängigkeitskämpfen, die mit der Vereinigung Italiens (die Risorgimento-Zeit endeten, und nachher an den Waffeninterventionen während der zwei Weltkriege. Seit der Mitte des 20. Jahrhunderts kehrte man zum früheren beiderseitigen Kontakt auf verschiedenen Ebenen zurück.In jeder dieser Zeitspannen wurde die polnische Anwesenheit in Italien in den schriftlichen, ikonografischen, künstlerischen Quellen belegt. Die meisten davon bewährten sich in den Archiven und Bibliotheken Roms, dem Zentrum der europäischen Wissenschaft, Kultur und Christenheit. Erst im 20. Jahrhundert, seit der Entstehung der ersten wissenschaftlichen polnischen Institutionen in Rom und dank der breiten Zusammenarbeit war es möglich, die Polonica, die sich in den römischen Bibliotheken, Archiven, Kulturinstitutionen und Privatbeständen befinden, offiziell zu registrieren, bearbeiten und ordnen. Die schriftlichen Denkmäler aus den vergangenen Jahrhunderten weisen auf eine breite gegenseitige Beziehung sowohl im Bereich des sacrum als auch des profanum hin. Dieses gemeinsame historische Gedächtniserbe zeugt von einer langen Zugehörigkeit Polens zur

Pathogenesis and immunotherapy in cutaneous psoriasis: what can rheumatologists learn?

Science.gov (United States)

Alexander, Helen; Nestle, Frank O

2017-01-01

This review presents our current understanding of the pathogenesis and treatment of psoriasis with a particular focus on recent areas of research and emerging concepts. Psoriasis arises in genetically predisposed individuals who have an abnormal innate and adaptive immune response to environmental factors. Recent studies have identified novel genetic, epigenetic and immunological factors that play a role in the disease pathogenesis. There is emerging evidence for the role of the skin microbiome in psoriasis. Studies have shown reduced diversity and altered composition of the skin microbiota in psoriasis. Recent advances in our understanding of the complex immunopathogenesis of psoriasis have led to the identification of crucial cytokines and cell signalling pathways that are targeted by a range of immunotherapies.

Den bureaukratiske elite

DEFF Research Database (Denmark)

Krarup, Troels

2012-01-01

Artiklen kortlægger ved korrespondanceanalyse karriereveje for 122 topembedsmænd i centraladministrationen. Artiklen har tre anliggender: 1) at opdatere og nuancere billedet af den bureaukratiske elite i Danmark, som det kendes fra tidligere politologiske studier; 2) at positionere analysen i et...... europæisk perspektiv og i forhold til en anden dansk elite, topdirektører; og 3) at eksemplificere visse teoretiske og metodiske fordele ved felt- og korrespondanceanalyser uden så nær anknytning til Bourdieus sociologi, som det almindeligvist ses i magtstudier, bl.a. ved at introducere brug af idealtyper...

Den humane teknologi

DEFF Research Database (Denmark)

Fausing, Bent

2008-01-01

Artiklen undersøger hverdagsæstetikkens forestillinger om teknologi i tv-reklamer, nærmere bestemt to mobiltelefoner fra Nokia. Nokias slogan er som bekendt: "Nokia -connecting people". Hvilken funktion tilskrives denne succes-teknologi via billeder, narrativer, lyde, interaktioner og affekter...... personifikation eller antropomorfisering er vigtig for branding af den ny teknologi. Teknologien bliver betragtet som skaber af en teknotranscendens mod en mere kvalificeret humanitet, som er i kontakt med fundamentale humane værdier som intuition, fantasi og sansning. Det drejer sig i alle tilfælde om kvaliteter...

Jamie Oliver i den gode smags tjeneste

DEFF Research Database (Denmark)

Leer, Jonatan

2014-01-01

det gode liv er i stigende grad blevet en central del af genren i dag, hvor særligt kogebogsforfatternes privatliv og livsstil – altså et selvbiografisk element – er blevet et bærende narrativ i mange kogebøger. Med sådanne iscenesættelser og dramatiseringer af forestillinger om det gode liv bevæger...... den gode sags tjeneste først og fremmest tjener til at skabe et positivt billede af tv-kokken/kogebogsforfatteren som etisk individ (og brand) på bekostning af de gastronomisk nødstedte. Det skal nævnes, at jeg i min læsning af Jamies kogebogs-kampskrift har ladet mig inspirere af den russisk...

Abort inom den islamiska rättstraditionen

OpenAIRE

Sayed, Mosa

2013-01-01

Den svenska patientpopulationens stora heterogenitet, exempelvis med hänsyn till etnicitet, kultur, religion och nationell härkomst, kan på olika sätt påverka hur patienter uppfattar vad som utgör god vård. Islam och muslimer utgör idag en del av det svenska samhället och representerar en beaktansvärd del av dem som vänder sig till hälso- och sjukvården. Forskning om islam och frågor rörande hälso- och sjukvård i den svenska kontexten är dock begränsad. Inte minst gäller det synen på abort in...

Den udødelige gangster

DEFF Research Database (Denmark)

Bjerre, Thomas Ærvold

2009-01-01

Hollywood har igennem et århundrede hyldet de voldspsykopater, som de fleste gangstere nu engang er. Michael Manns Public Enemies er seneste skud på stammen i den lange række af amerikanske gangsterfilm, der tog sin begyndelse i starten af 1930'erne, og som meget hurtig blev til en mytisk...

Berlusconi og den moderne fyrste

DEFF Research Database (Denmark)

Sørensen, Gert

voksende forbrugermentalitets gennembrud. Tredje del sætter ind over for Berlusconis frontale angreb på de demokratiske principper og samler op omkring Italiens dybe krise. Den gennemgående analytiske figur er hentet fra Machiavellis Fyrsten om magtens mål og med. Dele af bogen er blevet til i samarbejde...

Publikum svinger den retoriske taktstok

DEFF Research Database (Denmark)

Hansen, Jette Barnholdt

2012-01-01

Artiklen handler om revyvisen "Man binder os på mund og hånd" af Poul Henningensen med musik af Kai Normann Andersen, som oprindeligt var en del af den kulturradikale revykomedie Dyveke fra 1940, der bla. advokerede for seksuel frigørelse. Visen levede dog hurtigt sit eget liv uden for revyteatret...

Dens Evaginatus: A Problem-Based Approach

Directory of Open Access Journals (Sweden)

A. Ayer

2015-01-01

Full Text Available Dens evaginatus is an uncommon developmental anomaly of human dentition characterized by the presence of tubercle on the occlusal surface of mandibular premolars and lingual surface of anterior teeth. Due to occlusal trauma this tubercle tends to fracture thus exposing the pathway to the pulp chamber of teeth. This case report is about the presentation of dens evaginatus in mandibular premolars bilaterally; among them tooth 44 was associated with chronic apical periodontitis. Fractured tubercle of three premolars was sealed with composite resin. Root canal treatment was performed with tooth 44. Routine endodontic treatment did not result in remission of infection. Therefore, culture and sensitivity tests were performed to identify the cause and modify treatment plan accordingly. Triple antibiotic paste was used as an intracanal medicament to disinfect the root canal that resulted in remission of infection.

Den 'dygtige' lærer er en del af problemet

DEFF Research Database (Denmark)

Hedegaard-Sørensen, Lotte

2016-01-01

Lærerne lever faktisk op til politikernes forestilling om ’den gode undervisning’, men dermed bliver de en del af problemet og ikke løsningen på folkeskolens inklusionsudfordring......Lærerne lever faktisk op til politikernes forestilling om ’den gode undervisning’, men dermed bliver de en del af problemet og ikke løsningen på folkeskolens inklusionsudfordring...

Rapportering om going concern i den nye revisionspåtegning

DEFF Research Database (Denmark)

Seehausen, Jesper

2017-01-01

Artiklen omhandler revisors rapportering om going concern i den nye revisionspåtegning. Det er artiklens centrale budskab, at der i den nye revisionspåtegning alene er ændringer til, hvordan revisor skal rapportere om going concern i revisionspåtegningen. Der er derimod ikke ændringer til, hvornår...... revisor skal rapportere om going concern i revisionspåtegningen....

Type II dens evaginatus of maxillary central incisor: An alternative approach

Directory of Open Access Journals (Sweden)

Mansour Alrejaie

2015-01-01

Full Text Available Dens evaginatus is the developmental anomaly of tooth that exhibits protrusion of a tubercle from occlusal surfaces of premolar, and lingual surfaces of maxillary central incisor and lateral incisors. Dens evaginatus is common in Caucasian population. Saudi Arabia is also well evidenced of such cases. These tubercles have an enamel layer covering dentin core containing a thin extension of pulp. These cusp-like protrusions are susceptible to pulp exposure from wear or fracture because of malocclusion. Type II dens evaginatus involves normal pulp with immature root apex. Materials to enhance the pulpal recession or pulpotomy procedures indicated in such cases require long time and efforts to ensure pulpal recession or root maturity, respectively. Also prolonged treatment has risk of fracture of the cusp and reinfection and requires patient commitment for the follow-up procedures. Present case describes the use of mineral trioxide aggregate (MTA in type II dens evaginatus of maxillary central incisor.

Die Umweltschäden und Entsorgungsprobleme des russischen Nuklearkomplexes

OpenAIRE

Kronfeld-Goharani, Ulrike

2002-01-01

"Als Nachfolgestaat der ehemaligen Sowjetunion mit ihrer gigantischen Nuklearindustrie zählt Russland heute zu den Ländern, in denen sich große Mengen Nuklearmüll angereichert haben und einzelne Regionen des Landes von radioaktiven Kontaminationen besonders stark betroffen sind. Ungeachtet dessen änderte im Juni 2001 das russische Parlament das Umweltgesetz, um verbrauchten Nuklearbrennstoff aus dem Ausland in großen Mengen zu importieren. Während Befürworter der Gesetzesänderungen den Import...

Den ecology of Octopus vulgaris Cuvier, 1797, on soft sediment: availability and types of shelter

Directory of Open Access Journals (Sweden)

Stelios Katsanevakis

2004-03-01

Full Text Available To avoid predation, octopuses select and actively modify shelters (also called dens in the substratum, where they remain most of the time, especially during daylight hours. The main questions that this study deals with are: Is den availability a significant constraint for the distribution of Octopus vulgaris on soft sediment? What kind of dens does O. vulgaris use on soft sediment and what factors affect the selection of one type instead of another? With population density measurements by SCUBA diving and enrichment experiments with artificial dens, we concluded that the availability of solid materials necessary for den construction is a limiting factor for the distribution of O. vulgaris on soft sediment. O. vulgaris used four different types of den on soft sediment: well (a vertical hole in the sediment, rock/stone (the octopus uses a rock or a large stone to dig a cavity under it, shell (an empty shell is used, human origin (a solid material of human origin is used. The relative proportion of the four types of den in the areas studied was: 38.7% human origin, 29.7% well, 21.5% rock/stone, 2.9% shell. Also, 7.3% of the octopuses were found outside their den. The main types of den were found in different relative proportions in relation to the depth, the distance from shore, the octopus size and the granulometry of the sediment.

Frede P. Jensen og den danske indkredsning af Vasatidens Sverige 40 år efter

DEFF Research Database (Denmark)

Andersen, Dan H.

2016-01-01

Artiklen er en analyse af receptionen af Frede P. Jensens kritik af den svenske historiker Arthur Stilles indflydelsesrige teori fra 1918 om årsagerne den svenske stormagts opståen. Stilles teori så den svenske politik som et grundlæggende defensivt og eksistentielt svar på en dansk indkredsning af...

Tillid i den finansielle sektor

DEFF Research Database (Denmark)

Rimmer, Nina Røhr; Nielsen, Sara Møller; Benediktsdottir, Elisabet

2014-01-01

, der er i kommunikation med kunden, eksempelvis at videreudvikle på definerede Touch-Points i CEM og opbyggelsen/vedligeholdelsen af kundeoplysninger i CRM systemer således, at den samlede kvalitet af ydelsen bliver så personlig som mulig, hvilket falder godt i tråd med Spar Nords værdigrundlag om dels...

Verzwickte Flussgemeinschaft - Warum es so schwierig ist, den Flüssen Raum zu geben

NARCIS (Netherlands)

Hartmann, T.

2011-01-01

Extreme Hochwasser verursachen enorme Schäden in Flusslandschaften. Flussgemeinschaften müssen künftig den Flüssen mehr Raum geben, um Hochwasser in der Fläche zurückzuhalten, statt in der Höhe (der Deiche) zu bekämpfen. Die Idee „den Flüssen mehr Raum geben“ beschreibt eigentlich etwas

Können Statine den Knochenstoffwechsel positiv beeinflussen?

Directory of Open Access Journals (Sweden)

Vock L

2005-01-01

Full Text Available Statine, potente Inhibitoren der HMG-CoA-Reduktase, werden erfolgreich zur Senkung der Cholesterinblutspiegel eingesetzt. In den letzten Jahren sind jedoch zahlreiche andere Wirkungen der Statine aufgedeckt worden, die möglicherweise für den Knochenstoffwechsel von Bedeutung sind: In vitro konnten faszinierende knochenanabole Wirkungen der Statine bewiesen werden. Welche molekularen Mechanismen für diese Beobachtungen genau verantwortlich sind, ist nach wie vor unklar. Auch konnten in anderen In-vitro-Studien, Tiermodellen und klinischen Studien diese eindrucksvollen Resultate nicht immer bestätigt werden. Das vorliegende Bild der Statine im Knochenstoffwechsel ist uneinheitlich. Viele Fragen bleiben offen. Es fehlen neben genaueren Erkenntnissen über die Eigenschaften der einzelnen Statine auch Resultate besser auf diese Fragestellung zugeschnittener Studien.

Cone-beam computed tomography for assessment of dens invaginatus in the Polish population.

Science.gov (United States)

Różyło, T Katarzyna; Różyło-Kalinowska, Ingrid; Piskórz, Magdalena

2018-01-01

There are many developmental variations in the permanent dentition. Dens invaginatus can be recognized on many dental X-rays of affected patients, but not every image allows for assessment of the type of malformation. The aim of the present study was to assess the presence of dens invaginatus with radiological features using cone-beam computed tomography (CBCT). CBCT images of 33 patients were evaluated. Age, sex, side, lateralization, occurrence in a particular group of teeth, type of invagination, differentiation, and the consequences of these factors were analyzed. Forty-one teeth with dens invaginatus met the inclusion criteria for this evaluation. Females were affected more frequently than males (57.6 vs. 42.4%, respectively). The patients' age ranged from 7 to 40 years, and the occurrence of dens invaginatus peaked from age 9 to 13 years. In total, 92.7% of affected teeth were present in the maxilla, more often unilaterally (75.8%) than bilaterally (24.2%). The most frequent tooth with dens invaginatus was the maxillary lateral incisor (53.7% of affected teeth). Almost two-thirds (63.4%) of affected teeth were found on the left side and 36.6% were found on the right. The tooth anatomy was distorted within the crown and root. Dens invaginatus sometimes affected other surrounding teeth and reduced their esthetics. The obtained data indicate that CBCT examination is an essential tool in assessing dens invaginatus and can guide dental practitioners in treating patients who exhibit characteristic features of this disorder. CBCT allows the clinician to distinguish the type of anomaly.

Morbillivirus Experimental Animal Models: Measles Virus Pathogenesis Insights from Canine Distemper Virus.

Science.gov (United States)

da Fontoura Budaszewski, Renata; von Messling, Veronika

2016-10-11

Morbilliviruses share considerable structural and functional similarities. Even though disease severity varies among the respective host species, the underlying pathogenesis and the clinical signs are comparable. Thus, insights gained with one morbillivirus often apply to the other members of the genus. Since the Canine distemper virus (CDV) causes severe and often lethal disease in dogs and ferrets, it is an attractive model to characterize morbillivirus pathogenesis mechanisms and to evaluate the efficacy of new prophylactic and therapeutic approaches. This review compares the cellular tropism, pathogenesis, mechanisms of persistence and immunosuppression of the Measles virus (MeV) and CDV. It then summarizes the contributions made by studies on the CDV in dogs and ferrets to our understanding of MeV pathogenesis and to vaccine and drugs development.

Den site activity patterns of adult male and female swift foxes, Vulpes velox, in Northwestern Texas

Science.gov (United States)

Lemons, P.R.; Ballard, W.B.; Sullivan, R.M.; Sovada, M.A.

2003-01-01

Activity of Swift Foxes (Vulpes velox) at den sites was studied in northwestern Texas during pup rearing seasons in 2000 and 2001 to determine role of males in parental care. Twenty-four percent of radio-collared females with a potential to breed successfully raised pups to eight weeks of age. We intensively monitored presence and absence of male and female Swift Foxes at two den sites each year. Females were present >2.6 times more at den sites than males during the pup rearing season. Female and male Swift Foxes largely stayed at dens during diurnal hours and were active away from dens during nocturnal and crepuscular hours. Females and males spent 12.4% and 3.0% more time at dens before pups emerged, than after pups emerged, respectively. Following depredation of one male parent, the female spent 29% less time at the den site. Decrease in time spent at the den by the female following loss of her mate suggested that loss of one parent might severely impact recruitment of Swift Foxes. Our observations indicated that intense Coyote (Canis latrans) depredation may severely impact pup-rearing success as well as the parental care within Swift Fox family groups.

Influenza A Virus-Host Protein Interactions Control Viral Pathogenesis.

Science.gov (United States)

Zhao, Mengmeng; Wang, Lingyan; Li, Shitao

2017-08-01

The influenza A virus (IAV), a member of the Orthomyxoviridae family, is a highly transmissible respiratory pathogen and represents a continued threat to global health with considerable economic and social impact. IAV is a zoonotic virus that comprises a plethora of strains with different pathogenic profiles. The different outcomes of viral pathogenesis are dependent on the engagement between the virus and the host cellular protein interaction network. The interactions may facilitate virus hijacking of host molecular machinery to fulfill the viral life cycle or trigger host immune defense to eliminate the virus. In recent years, much effort has been made to discover the virus-host protein interactions and understand the underlying mechanisms. In this paper, we review the recent advances in our understanding of IAV-host interactions and how these interactions contribute to host defense and viral pathogenesis.

Den Danske Netordbog

DEFF Research Database (Denmark)

Bergenholtz, Henning; Vrang, Vibeke; Almind, Richard

Denne danske ordbog er primært tænkt som hjælpeværktøj i forbindelse med tvivl og usikkerhed, når man skriver en dansk tekst. Den Danske Netordbog er en yderst omfattende ordbog med mere end 110.000 forskellige opslagsord og en lang række oplysninger, herunder grammatik, betydning, synonym (ord m...... samme betydning), antonym (ord med modsat betydning), orddannelse (i hvilke andre ord det pågældende ord er en del af), kollokationer (ordforbindelser), idiomer (fast udtryk med en særlig betydning) og ordsprog og citater....

Zahraniční publicistika časopisu Týden

OpenAIRE

Dvořáková, Zdenka

2010-01-01

The bachelor thesis "Foreign publicism of the Týden Magazine" cleals with publicistic texts with foreign topics published in the Týden Magazine. It tries to narned the genre (gloss, comment, editorial and column), which the first part of the thesis acts. This part clescribc s, how these genres should be written according to technicalliteraturc. The second part dwells on the main intent of the thesis, namely the measure of keeping these c1efinitions by authors. It also looks how they these gen...

Pathogenesis of Graves` disease and therapeutic implications; Pathogenese des Morbus Basedow und therapeutische Implikationen

Energy Technology Data Exchange (ETDEWEB)

Seif, F.J. [Tuebingen Univ. (Germany). Medizinische Klinik und Poliklinik

1997-12-01

Graves` disease presents itself clinically mainly as hyperthyroidism and infiltrative ophthalmopathy and to a minimal extent also as dermopathy and acropachy. Autoimmune processes are the basic pathogenesis. Stimulating antibodies against the TSH receptor cause hyperthyroidism. Autoantibodies and autoreactive T lymphocytes against primarily thyroidal antigens cross-react with similar antigens of the eye muscles and orbital connective tissue, thus spreading the disease from the thyroid to the eyes. The therapeutic goal comprises not only the treatment of hyperthyroidism, but also the induction of a steady immuntolerance in order to minimize the irreversible damage to the eye. The therapeutic armamentarium is formed by antithyroid drugs, glucocorticoids, retrobulbar radition and thyroid ablation, either by nearly total thyroidectomy or by radioiodine. The different indications for both ablative procedures are discussed. (orig.) [Deutsch] Der Morbus Basedow manifestiert sich klinisch hauptsaechlich als Hyperthyreose und infiltrative Orbitopathie, waehrend Demopathie und Akropathie selten sind. Der Krankheit liegt ein Autoimmunprozess zugrunde, wobei stimuliernde Autoantikoerper gegen den TSH-Rezeptor die Hyperthyreose hervorrufen. Autoantikoerper und T-Lymphozyten gegen primaer thyreoidale Antigene verursachen durch Kreuzreaktion mit aehnlichen Antigenen an den Augenmuskeln und orbitalem Bindegewebe die Orbitopathie. Das therapeutsiche Ziel besteht nicht nur in der Behandlung der Hyperthyreose, sondern vor allem in der Induktion einer immuntoleranten Remission, um die irreversiblen Schaeden am Auge zu minimieren. Die Therapie umfasst Thyreostatika, Glukokortikoide und Orbitaspitzenbestrahlung sowie eine Schilddruesenablation entweder durch fast totale Schilddruesenresektion oder durch Radiojodtherapie. Die Differentialindikationen fuer die beiden ablativen Massnahmen werden eroertert. (orig.)

Den der ser, er den, der ses

DEFF Research Database (Denmark)

Bjerrum, Troels

2010-01-01

Udgangspunktet for afhandlingen er at undersøge, hvordan unge udsatte mennesker kan opnå personlig forandring ved hjælp af åndedrætstræning og meditation. Afhandlingen indleder med at beskrive de unges liv i en globalisering. Mange unge mennesker uden en social ansvarlig baggrund har ikke lært...... at foretage sig nødvendige samfundsmæssige valg. På grund af nederlag i hjem, skole, uddannelse og erhverv søger unge fællesskaber i ligestillede miljøer svarende til egen negative forventningspraksis. Den unge praktiserer en vanedannende negativ livsførelse, som eskalerer til yderligere socialt forfald. Unge......, der har levet i kriminalitet, misbrug og medmisbrug i lang tid, vil ikke være i stand til at realisere sig positivt pga. en personlig indgroet diskvalificerende forestilling. Afhandlingen forklarer, hvorledes negative oplevelser forbliver spændinger i menneskers krop. Teorier af Maurice Merleau...

Den årlige klining af moskéen i Jenné

DEFF Research Database (Denmark)

Andreasen, Jørgen

2007-01-01

Danske studerende hjælper med kliningen af den store moské i Jenné under 'Mohammed-krisen'. Jenné er et af UNESCO's 'heritage sites' - en by helt bygget i ler. Vedligeholdelse og årlig klining er nødvendig. Moskeen er den største bygning, lukket for ikke-muslimer. Det danske hold fik adgang til m...

Den onde eller det onde?

DEFF Research Database (Denmark)

Nielsen, Kirsten

2008-01-01

Artiklen handler om brugen af billeder for den onde (djævelen) og det onde i moderne salmer. Der er en klar tendens til at foretrække et naturbillede som mørket frem for personbilleder. Mørket kan som billede bruges forholdsvis nuanceret og vil i mange tilfælde ikke forudsætte et dybere kendskab ...

van den Heuvel, Prof. Edward P J

Indian Academy of Sciences (India)

van den Heuvel, Prof. Edward P J . Date of birth: 2 November 1940. Address: Professor of Astrophysics, Astronomical Inst. Anton Pannekoek, Postbus 94249, 1090 GE Amsterdam, The Netherlands Contact: Office: (+31-20) 525 ...

Digital kommunikation med den offentlige sektor

DEFF Research Database (Denmark)

Berger, Jesper Bull; Andersen, Kim Normann

til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs. uden at uvedkommende kan få adgang til...... følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Undersøgelsen medtager myndighedernes besvarelse af digital post og e-mail, dels for at kunne...... sammenligne de to digitale kanaler og for at kunne sammenligne med en tidligere undersøgelse af digital kommunikation med det offentlige. Herudover er der tidligere gennemført en undersøgelse af e-mail svar og svartider i New Zealand og Australien. De danske resultater fra e-mail undersøgelsen, men ikke...

Kurz zum Klima: Zu viel Salz verdirbt den Boden

OpenAIRE

Zimmer, Markus; Lippelt, Jana; Frank, Jonas

2012-01-01

Der zunehmende Einsatz von Anlagen zur Bewässerung sowie mangelnde Erfahrungswerte und Unkenntnis über den richtigen Einsatz der künstlichen Bewässerung haben in den letzten Jahrzehnten zu einer massiven Zunahme der Versalzung des Bodens geführt. Durch diese Bodenversalzung werden weite Flächen für die Landwirtschaft unbrauchbar. Sie sind nur durch hohen Aufwand und Kosten wieder renaturierbar. Der Beitrag in der Reihe »Kurz zum Klima« gibt einen Überblick über die Versalzung in Anbaugebiet...

Facial Cellulitis Arising from Dens Evaginatus: A Case Report

Directory of Open Access Journals (Sweden)

Chun-Ming Chen

2005-07-01

Full Text Available Dens evaginatus is a developmental anomaly that produces a tubercle on the occlusal surface of a tooth. It is found most frequently in the mandibular premolars. The occlusal tubercle easily causes occlusal interferences. Attrition or fracture of the tubercle can lead to pulpitis, pulp necrosis, periapical pathosis, and periapical infection. This case report illustrates the treatment of facial cellulitis arising from dens evaginatus with open apex. Calcium hydroxide was used for the apexification procedure. One year after canal obturation, radiography revealed no apical pathosis and the apical seal was evident.

CIOs mangler fundamentale egenskaber for at lede den digitale transformation

DEFF Research Database (Denmark)

Bjørn-Andersen, Niels

2016-01-01

CIOs er dårligt rustet til at gå i spidsen for digital disruption og innovation, advarer den internationale topforsker Joe Peppard med afsæt i analyse af mere end 200 CIO-s personligheder......CIOs er dårligt rustet til at gå i spidsen for digital disruption og innovation, advarer den internationale topforsker Joe Peppard med afsæt i analyse af mere end 200 CIO-s personligheder...

[Establishing Individualized Medicine for Intractable Cancer Based on Clinical Molecular Pathogenesis].

Science.gov (United States)

Jono, Hirofumi

2018-01-01

　Although cancer treatment has dramatically improved with the development of molecular-targeted agents over the past decade, identifying eligible patients and predicting the therapeutic effects remain a major challenge. Because intratumoral heterogeneity represents genetic and molecular differences affecting patients' responses to these therapeutic agents, establishing individualized medicine based on precise molecular pathological analysis of tumors is urgently required. This review focuses on the pathogenesis of oral squamous cell carcinoma (OSCC), a common head and neck neoplasm, and introduces our approaches toward developing novel anticancer therapies particularly based on clinical molecular pathogenesis. Deeper understanding of more precise molecular pathogenesis in clinical settings may open up novel strategies for establishing individualized medicine for OSCC.

Advances in understanding the pathogenesis of primary familial and congenital polycythemia

Science.gov (United States)

Huang, Lily Jun-shen; Shen, Yu-Min; Bulut, Gamze B.

2010-01-01

Summary Primary familial and congenital polycythemia (PFCP) is an autosomal-dominant proliferative disorder characterized by erythrocytosis and hypersensitivity of erythroid progenitors to erythropoietin (Epo). Several lines of evidence suggest a causal role of truncated erythropoietin receptor (EpoR) in this disease. In this review, we discuss PFCP in the context of erythrocytosis and EpoR signaling. We focus on recent studies describing mechanisms underlying Epo-dependent EpoR down-regulation. One mechanism depends on internalization mediated through the p85 regulatory subunit of the Phosphoinositide 3-Kinase, and the other utilizes ubiquitin-based proteasomal degradation. Truncated PFCP EpoRs are not properly down-regulated upon stimulation, underscoring the importance of these mechanisms in the pathogenesis of PFCP. PMID:20096014

Tre teorier om den moralske udvikling

DEFF Research Database (Denmark)

Bo, Inger Glavind; Andreasen, Brian Kjær

I artiklen gennemgås tre forskellige men teorihistorisk relaterede perspektiver på forståelsen af moralsk udvikling: Piaget, Kohlberg og Gilligan. I den efterfølgende diskussion af disse teoretikeres respektive positioner påpeges såvel forskelle som ligheder i deres betoning af moralens karakter...

How a sugary bug gets through the day: Recent developments in understanding fundamental processes impacting Campylobacter jejuni pathogenesis

OpenAIRE

Szymanski, Christine M.; Gaynor, Erin

2012-01-01

Campylobacter jejuni is a highly prevalent yet fastidious bacterial pathogen that poses a significant health burden worldwide. Lacking many hallmark virulence factors, it is becoming increasingly clear that C. jejuni pathogenesis involves different strategies compared with other well-characterized enteric organisms. This includes the involvement of basic biological processes and cell envelope glycans in a number of aspects related to pathogenesis. The past few years have seen significant prog...

Emma Bentz: I stadens skugga. Den medeltida landsbygden som arkeologiskt forskningsfält

DEFF Research Database (Denmark)

Kristiansen, Mette Svart

2009-01-01

Anmeldelse af doktordisputats, Lunds Universitet. Afhandlingen omhandler etableringen af den middelalderlige landbebyggelse som arkæologisk forskningsfelt fra 1930érne til i dag samt etableringen og vedligeholdelsen af et forskningsfelt indenfor den humanistiske videnskab....

Den danske fødevaresektor

DEFF Research Database (Denmark)

Bosselmann, Aske Skovmand; Gylling, Morten

2012-01-01

Den danske fødevaresektor har et højt niveau for så vidt angår miljø og bæredygtighed. Der kan være et potentiale for vækst og beskæftigelse i at bruge dette relativt høje niveau til at give danske virksomheder adgang til attraktive eksportmarkeder, hvor fødevarer, der er dokumenteret bæredygtige...

Financial Inclusion: Reformen in den Bereichen Verbraucherschutz und finanzielle Allgemeinbildung

OpenAIRE

Christa Hainz

2011-01-01

Nicht zuletzt der Mangel an wirksamer Offenlegung von Informationen und irreführende Werbung auf Seiten der Anbieter sowie mangelndes Verständnis bezüglich Finanzprodukten auf Seiten der Konsumenten trugen dazu bei, dass der Markt für Subprime-Hypotheken in den USA zusammenbrach. Eine Verbesserung dieses institutionellen Umfelds sollte deshalb dazu dienen, derart negative Entwicklungen in der Zukunft zu verhindern. Der Beitrag gibt einen Überblick, welche Industrieländer Reformen in den Berei...

Shareholder Kapitalismus und das Casino Spiel an den Börsen

OpenAIRE

Young, Brigitte; Hegelich, Simon

2003-01-01

'Das Konzept des Shareholder Value ist durch die jüngsten Entwicklungen im Unternehmenssektor, vor allem durch die Bilanz- und Betrugsskandale von TNC's und die damit verbundene Vernichtung von Arbeitsplätzen in die Kritik geraten. In den politischen Debatten über Shareholder Value wird ein Systemunterschied zwischen dem 'Stakeholder-Ansatz' (wie im rheinischen Kapitalismus) und dem mit der Liberalisierung der Finanzmärkte Ende der 70er Jahre in den USA entwickelten Begriff Shareholder Value ...

Den narrative tilgang

DEFF Research Database (Denmark)

Bo, Inger Glavind

2016-01-01

I kapitlet gennemgås en socialkonstruktivistisk forståelse af narrativer. I kapitlet vil jeg gennemgå centrale teoretiske pointer, der samlet set er grundlæggende for en social konstruktivistisk forståelse af narrativer for herved at udfolde forståelsen af den narrative tilgang og desuden...... tydeliggøre, hvordan tilgangen er forbundet med en særlig forståelse af identitetsskabelse. Der er tale om pointer der almindeligvis forbindes med ”små fortællinger” i form af længere identitetsfortællinger og narrative interviews. Kapitlet gennemgår således centrale inspirationskilder og teoretiske pointer...

Nyliberalisme, universiteter og den akademiske frihed

DEFF Research Database (Denmark)

Madsen, Mogens Ove

2011-01-01

Den akademiske frihed er forbundet med absolut frihed til at frembringe og videreformidle viden. Denne ide med universitetet er blevet udfordret ganske kraftigt i de senere år, ikke kun i Danmark. Stærke rådgivningsinstitutioner som OECD og EU har i en del år anbefalet, at universiteternes opgave...

Types and forms of sleeping dens of pacas (Cuniculus paca in the upper Itaya river basin

Directory of Open Access Journals (Sweden)

Rolando Aquino

2012-10-01

Full Text Available This report deals with paca sleeping dens (Cuniculus paca Linnaeus, 1766. The study was conducted between August 2006 and April 2007 and is based on detailed observations. Results indicate that this rodent uses holes in the ground or in fallen trees as sleeping dens. Each of these sleeping dens had two or more orifices and an internal cavity for the "diurnal sleep”. Typically, one orifice was for common use and the rest for the circumstantial escape. According to their form, their localization in the ground, and the number and location of orifices, sleeping dens were classified into four types, of which type A was the most common. The results also indicate a greater concentration of sleeping dens in temporary flooded gallery forest.

Comparative Pathogenesis and Systems Biology for Biodefense Virus Vaccine Development

Directory of Open Access Journals (Sweden)

Gavin C. Bowick

2010-01-01

Full Text Available Developing vaccines to biothreat agents presents a number of challenges for discovery, preclinical development, and licensure. The need for high containment to work with live agents limits the amount and types of research that can be done using complete pathogens, and small markets reduce potential returns for industry. However, a number of tools, from comparative pathogenesis of viral strains at the molecular level to novel computational approaches, are being used to understand the basis of viral attenuation and characterize protective immune responses. As the amount of basic molecular knowledge grows, we will be able to take advantage of these tools not only to rationally attenuate virus strains for candidate vaccines, but also to assess immunogenicity and safety in silico. This review discusses how a basic understanding of pathogenesis, allied with systems biology and machine learning methods, can impact biodefense vaccinology.

Digital kommunikation med den offentlige sektor: Styrelser og statslige institutioner

DEFF Research Database (Denmark)

Berger, Jesper Bull; Andersen, Kim Normann

Denne rapport sammenfatter hovedresultaterne for styrelser og statslige organisationer af en undersøgelse gennemført i sommeren 2013 om besvarelse af e-mail og digital post i den statslige, regionale og kommunale sektor. Allerede med eDag3 1. nov. 2010 skulle alle myndigheder have oprettet en...... digital postkasse, som borgerne kunne skrive til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs....... uden at uvedkommende kan få adgang til følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Vi har også undersøgt besvarelse af e-mail, dels...

New discoveries in the pathogenesis and classification of vitiligo.

Science.gov (United States)

Rodrigues, Michelle; Ezzedine, Khaled; Hamzavi, Iltefat; Pandya, Amit G; Harris, John E

2017-07-01

Vitiligo is a common autoimmune disease that progressively destroys melanocytes in the skin, resulting in the appearance of patchy depigmentation. This disfiguring condition frequently affects the face and other visible areas of the body, which can be psychologically devastating. The onset of vitiligo often occurs in younger individuals and progresses for life, resulting in a heavy burden of disease and decreased quality of life. Presentation patterns of vitiligo vary, and recognition of these patterns provides both diagnostic and prognostic clues. Recent insights into disease pathogenesis offer a better understanding of the natural history of the disease, its associations, and potential for future treatments. The first article in this continuing medical education series outlines typical and atypical presentations of vitiligo, how they reflect disease activity, prognosis, and response to treatment. Finally, we discuss disease associations, risk factors, and our current understanding of disease pathogenesis. Copyright © 2016 American Academy of Dermatology, Inc. All rights reserved.

Droht den "kleinen Sprachen" das Aussterben?

Directory of Open Access Journals (Sweden)

Anita Lemić

2014-12-01

Full Text Available Die Prozesse der Globalisierung sind die Ursache für viele Änderungen in der Weltgemeinschaft, vor allem die Entfernung von Unterscheidungsmerkmalen (in Bezug darauf, dass „zwischen vielen ethnischen Zeichen, das was dauernd ist, ist die Dichotomisierung/Differenzierung eines „Wir-und-die-Anderen“ (Grbić, 2003, 93-64. Diese Zeichen wirken als Zeichen der Resozialisierung, die die bestehenden Identitäten löschen und sich an der Schaffung neuer Strukturen beteiligen. Die Zeit der Romantik in Europa ermöglichte die Schaffung von Nationalstaaten und ihr Hauptmerkmal war die Nationalsprache. Diese Art der sozialen Differenzierung hatte das Ziel, die Illusion einer vollständig homogenisierten Gesellschaft zu schaffen und damit den Prozess der Zerstörung der „kleinen“ Sprachen zu beginnen. Sprache und Kultur erwiesen sich als Grundlage der Gemeinschaftserhaltung. Die Homogenisierung ermöglicht Aktivitäten mit dem Ziel, einem Individuum zu helfen, sich als Individuum und als Mitglied der Gemeinschaft zu behaupten. Keine dieser beiden Identitäten kann ohne die Wechselwirkung mit der Umgebung erreicht werden. Die sprachliche Interaktion mit anderen Mitgliedern ist das Schlüsselsegment, das Menschen von anderen Lebensformen unterscheidet. Durch den Austausch von Erfahrungen mit anderen kommt der Mensch auf allen Ebenen voran und mit der Erfindung der Schrift öffnete er die Tür zur Entwicklung der Zivilisation. In dieser Arbeit beschäftigen wir uns mit der Frage der „Prestige“-Sprachen, die auf der Grundlage der Macht der Gemeinschaft der Muttersprachler ihren Bereich weit über die Grenzen des eigenen Landes hinaus erweitern und so eine politische und wirtschaftliche Vormachtstellung schaffen, aber auch mit den Auswirkungen jener Sprachen auf die Dekonstruktion oder möglicherweise vollständige Ausrottung der Sprachen, die auf diese Weise an Einfluss verlieren, unmodern werden und sich die Frage der Notwendigkeit ihrer

Hibernacula and summer den sites of pine snakes (Pituophis melanoleucus) in the New Jersey pine barrens

Science.gov (United States)

Burger, J.; Zappalorti, R.T.; Gochfeld, M.; Boarman, W.I.; Caffrey, M.; Doig, V.; Garber, S.D.; Lauro, B.; Mikovsky, M.; Safina, C.; Saliva, Jorge

1988-01-01

We examined eight summer dens (used only in summer) and seven hibernacula (occupied both in winter and summer) of the snake Pituophis melanoleucus in the New Jersey Pine Barrens, comparing above ground characteristics of hibernacula and summer dens with characteristics at nearby random points. Temperatures at the soil surface and at 10 cm depth were significantly warmer, and there was less leaf cover around the random points compared to the entrances of the hibernacula and summer dens. Hibernacula had significantly more vegetation cover within 5 m, more leaf cover over the burrow entrance, and were closer to trees than were summer dens. Most hibernacula and summer dens were beside old fallen logs (73%), the entrance tunnels following decaying roots into the soil. Excavation of the hibernacula and summer dens indicated that most hibernacula appeared to be dug by the snakes and had an average of eight side chambers and 642 cm of tunnels, compared to less than one side chamber and 122 cm of tunnels for summer dens. Except for hatchlings, most snakes in hibernacula were located in individual chambers off the main tunnel; all snakes were at depths of 50-111 cm (X̄ = 79 cm). Pine snakes may select optimum hibernation sites which reduce winter mortality.

Understanding the first Neolithic occupation of Cova d'En Pardo (Planes, Alicante: Preliminary results of the multidisciplinary analysis of levels VIII and VIIIB

Directory of Open Access Journals (Sweden)

Jorge Agatángelo Soler Díaz

2014-01-01

Full Text Available We present the results of excavations carried out in the Cova d'En Pardo (Planes, Alicante, specifically the levels VIII and VIIIb. The development of a multidisciplinary project has allowed to us characterize the occupation of a small cavity by the first farming communities associated with the Neolithization process of the east of Iberian Peninsula.

Einfluss repetitiver postprandialer Hyperglykämien auf den kardialen Ischämie- und Reperfusionsschaden

OpenAIRE

Elbing, Inka Lena

2008-01-01

Die vorliegende Arbeit befasste sich daher mit dem Effekt von Acarbose auf die durch Ischämie und Reperfusion verursachten myokardialen Schäden nach Saccharosebelastung bei gesunden Mäusen in vivo. Aus den Ergebnissen dieser Arbeit lässt sich ableiten, dass eine wiederholte postprandiale Hyperglykämie bei nicht - diabetischen Tieren ausreicht, um die durch Ischämie und Reperfusion verursachten Myokardschäden signifikant zu erhöhen. Dies kann durch eine Behandlung mit dem a - Glucosidase - Hem...

Digital kommunikation med den offentlige sektor

DEFF Research Database (Denmark)

Berger, Jesper Bull; Andersen, Kim Normann

, som enten via spørgeskema, e-mail eller telefon har givet os et enestående indblik i deres håndtering af den digitale kommunikation. Publikationen er et såkaldt workingpaper, hvor vi mere end gerne modtager forslag og kommentarer til forbedringer. Der er i publikationen en række aktive links til...

Co-occurrence of gemination and dens invaginatus: a case report

Directory of Open Access Journals (Sweden)

Sonika Achalli

2016-03-01

Full Text Available Gemination is a developmental anomaly where a single tooth bud attempts to split into two. It is also sometimes called as double tooth or twinning. Dens invaginatus is another developmental anomaly caused due to invagination of a portion of crown. These anomalies occur as separate entities. Co-occurrence of these two anomalies have been only reported four times in the literature. Here we present an extremely rare case of simultaneous occurrence of gemination and dens invaginatus in the same tooth. [Cukurova Med J 2016; 41(1.000: 175-177

Heading for the hills: risk avoidance drives den site selection in African wild dogs.

Science.gov (United States)

Jackson, Craig R; Power, R John; Groom, Rosemary J; Masenga, Emmanuel H; Mjingo, Ernest E; Fyumagwa, Robert D; Røskaft, Eivin; Davies-Mostert, Harriet

2014-01-01

Compared to their main competitors, African wild dogs (Lycaon pictus) have inferior competitive abilities and interspecific competition is a serious fitness-limiting factor. Lions (Panthera leo) are the dominant large carnivore in African savannah ecosystems and wild dogs avoid them both spatially and temporally. Wild dog young are particularly vulnerable and suffer high rates of mortality from lions. Since lions do not utilize all parts of the landscape with an equal intensity, spatial variation in lion densities can be exploited by wild dogs both during their general ranging behaviour, but more specifically when they are confined to a den with vulnerable young. Since patches of rugged terrain are associated with lower lion densities, we hypothesized that these comparatively safe habitats should be selected by wild dogs for denning. We investigated the relationship between the distribution of 100 wild dog den sites and the occurrence of rugged terrain in four wild dog populations located in Tanzania, Zimbabwe and South Africa. A terrain ruggedness index was derived from a 90 m digital elevation model and used to map terrain ruggedness at each site. We compared characteristics of actual and potential (random) den sites to determine how wild dogs select den sites. The distributions of wild dog dens were strongly associated with rugged terrain and wild dogs actively selected terrain that was more rugged than that available on average. The likelihood of encountering lions is reduced in these habitats, minimizing the risk to both adults and pups. Our findings have important implications for the conservation management of the species, especially when assessing habitat suitability for potential reintroductions. The simple technique used to assess terrain ruggedness may be useful to investigate habitat suitability, and even predict highly suitable denning areas, across large landscapes.

Heading for the hills: risk avoidance drives den site selection in African wild dogs.

Directory of Open Access Journals (Sweden)

Craig R Jackson

Full Text Available Compared to their main competitors, African wild dogs (Lycaon pictus have inferior competitive abilities and interspecific competition is a serious fitness-limiting factor. Lions (Panthera leo are the dominant large carnivore in African savannah ecosystems and wild dogs avoid them both spatially and temporally. Wild dog young are particularly vulnerable and suffer high rates of mortality from lions. Since lions do not utilize all parts of the landscape with an equal intensity, spatial variation in lion densities can be exploited by wild dogs both during their general ranging behaviour, but more specifically when they are confined to a den with vulnerable young. Since patches of rugged terrain are associated with lower lion densities, we hypothesized that these comparatively safe habitats should be selected by wild dogs for denning. We investigated the relationship between the distribution of 100 wild dog den sites and the occurrence of rugged terrain in four wild dog populations located in Tanzania, Zimbabwe and South Africa. A terrain ruggedness index was derived from a 90 m digital elevation model and used to map terrain ruggedness at each site. We compared characteristics of actual and potential (random den sites to determine how wild dogs select den sites. The distributions of wild dog dens were strongly associated with rugged terrain and wild dogs actively selected terrain that was more rugged than that available on average. The likelihood of encountering lions is reduced in these habitats, minimizing the risk to both adults and pups. Our findings have important implications for the conservation management of the species, especially when assessing habitat suitability for potential reintroductions. The simple technique used to assess terrain ruggedness may be useful to investigate habitat suitability, and even predict highly suitable denning areas, across large landscapes.

Mapping polar bear maternal denning habitat in the National Petroleum Reserve -- Alaska with an IfSAR digital terrain model

Science.gov (United States)

Durner, George M.; Simac, Kristin S.; Amstrup, Steven C.

2013-01-01

The National Petroleum Reserve–Alaska (NPR-A) in northeastern Alaska provides winter maternal denning habitat for polar bears (Ursus maritimus) and also has high potential for recoverable hydrocarbons. Denning polar bears exposed to human activities may abandon their dens before their young are able to survive the severity of Arctic winter weather. To ensure that wintertime petroleum activities do not threaten polar bears, managers need to know the distribution of landscape features in which maternal dens are likely to occur. Here, we present a map of potential denning habitat within the NPR-A. We used a fine-grain digital elevation model derived from Interferometric Synthetic Aperture Radar (IfSAR) to generate a map of putative denning habitat. We then tested the map’s ability to identify polar bear denning habitat on the landscape. Our final map correctly identified 82% of denning habitat estimated to be within the NPR-A. Mapped denning habitat comprised 19.7 km2 (0.1% of the study area) and was widely dispersed. Though mapping denning habitat with IfSAR data was as effective as mapping with the photogrammetric methods used for other regions of the Alaskan Arctic coastal plain, the use of GIS to analyze IfSAR data allowed greater objectivity and flexibility with less manual labor. Analytical advantages and performance equivalent to that of manual cartographic methods suggest that the use of IfSAR data to identify polar bear maternal denning habitat is a better management tool in the NPR-A and wherever such data may be available.

Conservative Management of Type III Dens in Dente Using Cone Beam Computed Tomography

Directory of Open Access Journals (Sweden)

K Pradeep

2012-01-01

Full Text Available Dens in dente, also known as dens invaginatus, dilated composite odontoma, or deep foramen caecum, is a developmental malformation that usually affects maxillary incisor teeth, particularly lateral incisors. It may occur in teeth anywhere within the jaws, other locations are comparatively rare. It can occur within both the crown and the root, although crown invaginations are more common. The use of cone beam computed tomography (CBCT is very helpful in endodontic diagnosis of complex anatomic variations. In this case we demonstrate the use of CBCT in the evaluation and endodontic management of a Type III dens in dente (Oehler′s Type III.

A non mouse-adapted dengue virus strain as a new model of severe dengue infection in AG129 mice.

Directory of Open Access Journals (Sweden)

Grace K Tan

Full Text Available The spread of dengue (DEN worldwide combined with an increased severity of the DEN-associated clinical outcomes have made this mosquito-borne virus of great global public health importance. Progress in understanding DEN pathogenesis and in developing effective treatments has been hampered by the lack of a suitable small animal model. Most of the DEN clinical isolates and cell culture-passaged DEN virus strains reported so far require either host adaptation, inoculation with a high dose and/or intravenous administration to elicit a virulent phenotype in mice which results, at best, in a productive infection with no, few, or irrelevant disease manifestations, and with mice dying within few days at the peak of viremia. Here we describe a non-mouse-adapted DEN2 virus strain (D2Y98P that is highly infectious in AG129 mice (lacking interferon-alpha/beta and -gamma receptors upon intraperitoneal administration. Infection with a high dose of D2Y98P induced cytokine storm, massive organ damage, and severe vascular leakage, leading to haemorrhage and rapid death of the animals at the peak of viremia. In contrast, very interestingly and uniquely, infection with a low dose of D2Y98P led to asymptomatic viral dissemination and replication in relevant organs, followed by non-paralytic death of the animals few days after virus clearance, similar to the disease kinetic in humans. Spleen damage, liver dysfunction and increased vascular permeability, but no haemorrhage, were observed in moribund animals, suggesting intact vascular integrity, a cardinal feature in DEN shock syndrome. Infection with D2Y98P thus offers the opportunity to further decipher some of the aspects of dengue pathogenesis and provides a new platform for drug and vaccine testing.

Videnskabsteorien og den reflekterende dømmekraft

DEFF Research Database (Denmark)

Jørgensen, Klaus Frovin

2007-01-01

I denne artikel diskuterer jeg Immanuel Kants videnskabssyn, som det tager sig ud i Kritik af dømmekraften. Udgangspunktet er erkendelsesteorien og i særdeleshed den såkaldte skemateori. For Kant findes der rene videnskaber og empiriske videnskaber. De rene videnskabers begreber er karakteriseret...... instrumentalisme, der hersker. Der er visse subjektive principper og maximer, som er mere ’naturlige’ og ’rigtige’ end andre. Kants typiske eksempler herpå er ideen om fuldstændig enhed af den videnskabelige erkendelse og ideen om teleologi i naturen – at intet i naturen er tilfældigt, og at alt har et formål....... Artiklen afsluttes ved at perspektivere og sammenstille Kants videnskabsfilosofi med Thomas Kuhns nutidige videnskabsteori. Jeg argumenterer for, at Kants og Kuhns teorier har fundamentale elementer og strukturer til fælles, og at de vigtigste fornuftsmæssige ideer og principper hos Kant går igen i Kuhns...

Astrovirus Pathogenesis

Directory of Open Access Journals (Sweden)

Cydney Johnson

2017-01-01

Full Text Available Astroviruses are a major cause of diarrhea in the young, elderly, and the immunocompromised. Since the discovery of human astrovirus type 1 (HAstV-1 in 1975, the family Astroviridae has expanded to include two more human clades and numerous mammalian and avian-specific genotypes. Despite this, there is still little known about pathogenesis. The following review highlights the current knowledge of astrovirus pathogenesis, and outlines the critical steps needed to further astrovirus research, including the development of animal models of cell culture systems.

Joop van den Bremen, Streektaalmuziek in Nederland

NARCIS (Netherlands)

A.J.C. van der Hoeven (Arno)

2015-01-01

textabstractIn 1996, folk music fan Joop van den Bremen started his website Streektaalmuziek in Nederland (“Regional language music in the Netherlands”).1 On this website he collects information on Dutch musicians singing in dialect.2 As of September 2014, his still expanding database contains 6,164

Die Entwicklung der Keramik von 3000 BP bis zur Gegenwart in den Tonebenen südlich des Tschadsees

OpenAIRE

Wiesmüller, Birgitt

2003-01-01

Den Kern der hier vorliegenden Arbeit bildet die Gliederung der Keramikfunde von drei Siedlungshügeln aus den Tonebenen (auch firki genannt) des südwestlichen Tschadbeckens Nordost- Nigerias. Obwohl das Gebiet in den 60er Jahren bereits archäologisch erschlossen wurde, waren die keramikchronologischen Aspekte nur oberflächlich abgehandelt worden. Ziel der Arbeit war somit die Erstellung einer grundlegenden Keramikchronologie anhand der sehr umfangreichen Fundmengen aus den Siedlungshügeln Kur...

Käden pakotettu käyttö : vaikuttava aivohalvauspotilaan kuntoutusmenetelmä

OpenAIRE

Hänninen, Kati; Näsi, Minna

2007-01-01

Opinnäytetyön tarkoituksena oli käsitellä käden pakotettua käyttöä aivohalvauspotilaan kuntoutusmenetelmänä ja tuoda esille sen vaikuttavuutta halvaantuneen yläraajan toimintakyvyn edistämisen kannalta. Tavoitteena oli kirjallisuuskatsauksen ja tapausesimerkin avulla luoda kattava kokonaisuus käden pakotetun käytön kuntoutuksesta. Lähdeaineistona käytettiin uusimpia aiheeseen liittyviä tutkimuksia, monipuolista kirjallisuutta sekä tapausesimerkin henkilökohtaisia tiedonantoja. Opinnäytetyössä...

The TRIPS (Toll-like receptors in immuno-inflammatory pathogenesis) Hypothesis: a novel postulate to understand schizophrenia.

Science.gov (United States)

Venkatasubramanian, Ganesan; Debnath, Monojit

2013-07-01

Mounting evidence indicates that immune activation and/or immuno-inflammatory reactions during neurodevelopment apparently contribute to the pathogenesis and progression of schizophrenia. One of the important environmental factors that is known to trigger immune activation/inflammatory responses during early pregnancy is prenatal infection. Recent understanding from animal studies suggests that prenatal infection induced maternal immune activation (MIA)/inflammation in congruence with oxidative/nitrosative stress can lead to neurodevelopmental damage and behavioral abnormalities in the offspring. Although the underlying precise mechanistic processes of MIA/inflammation are yet to be completely elucidated, it is being increasingly recognized that Toll-like receptors (TLRs) that form the first line of defense against invading microorganisms could participate in the prenatal infection induced immune insults. Interestingly, some of the TLRs, especially TLR3 and TLR4 that modulate neurodevelopment, neuronal survival and neuronal plasticity by regulating the neuro-immune cross-talk in the developing and adult brain could also be affected by prenatal infection. Importantly, sustained activation of TLR3/TLR4 due to environmental factors including infection and stress has been found to generate excessive reactive oxygen species (ROS)/reactive nitrogen species (RNS) as well as pro-inflammatory mediators during embryogenesis, which result into neuronal damage by necrosis/apoptosis. In recent times, ROS/RNS and immuno-inflammatory mediators are being increasingly linked to progressive brain changes in schizophrenia. Although a significant role of TLR3/TLR4 in neurodegeneration is gaining certainty, their importance in establishing a causal link between prenatal infection and immuno-inflammatory, oxidative and nitrosative stress (IO&NS) responses and influence on adult presentation of schizophrenia is yet to be ascertained. We review here the current knowledge generated from

Pladebranchen - om den ændrede mediesituation i Danmark

Directory of Open Access Journals (Sweden)

Poul Martin Bonde

1992-08-01

Full Text Available Lanceringen af nye plader i radio og TV er afgørende elementer i mar- kedsføringen. Den danske pladebranche var sen til at udnytte de nye muligheder som åbnede sig med lokalradioerne i 1983 - men i dag giver en kombination af henved 50 store lokalradioer og tre TV-kanaler (DR, TV2 og TV3 samt i mindre omfang satellitkanalerne, helt nye muligheder for at få nye musiknavne frem i publikums øre- og øjenhøjde. Det har givet uoverskuelighed med indtil videre også en ny alsidighed og vitalitet i pladeproduktionen i Danmark. Både med hensyn til de unges rock og den bredere folkelighed med Jodle Birge osv.. Poul Martin Bonde er free-lance musikkonsulent og -skribent og rapporterer her fra er sted midt mellem publikum og dansk medie- og musikindustri.

Neutralizing Antibodies and Pathogenesis of Hepatitis C Virus Infection

Directory of Open Access Journals (Sweden)

Françoise Stoll-Keller

2012-10-01

Full Text Available Hepatitis C virus (HCV infection is a major cause of chronic liver disease worldwide. The interplay between the virus and host innate and adaptive immune responses determines the outcome of infection. There is increasing evidence that host neutralizing responses play a relevant role in the resulting pathogenesis. Furthermore, viral evasion from host neutralizing antibodies has been revealed to be an important contributor in leading both to viral persistence in acute liver graft infection following liver transplantation, and to chronic viral infection. The development of novel model systems to study HCV entry and neutralization has allowed a detailed understanding of the molecular mechanisms of virus-host interactions during antibody-mediated neutralization. The understanding of these mechanisms will ultimately contribute to the development of novel antiviral preventive strategies for liver graft infection and an urgently needed vaccine. This review summarizes recent concepts of the role of neutralizing antibodies in viral clearance and protection, and highlights consequences of viral escape from neutralizing antibodies in the pathogenesis of HCV infection.

Evolving Concepts in the Pathogenesis of NASH: Beyond Steatosis and Inflammation

Directory of Open Access Journals (Sweden)

William Peverill

2014-05-01

Full Text Available Non-alcoholic steatohepatitis (NASH is characterised by hepatic steatosis and inflammation and, in some patients, progressive fibrosis leading to cirrhosis. An understanding of the pathogenesis of NASH is still evolving but current evidence suggests multiple metabolic factors critically disrupt homeostasis and induce an inflammatory cascade and ensuing fibrosis. The mechanisms underlying these changes and the complex inter-cellular interactions that mediate fibrogenesis are yet to be fully elucidated. Lipotoxicity, in the setting of excess free fatty acids, obesity, and insulin resistance, appears to be the central driver of cellular injury via oxidative stress. Hepatocyte apoptosis and/or senescence contribute to activation of the inflammasome via a variety of intra- and inter-cellular signalling mechanisms leading to fibrosis. Current evidence suggests that periportal components, including the ductular reaction and expansion of the hepatic progenitor cell compartment, may be involved and that the Th17 response may mediate disease progression. This review aims to provide an overview of the pathogenesis of NASH and summarises the evidence pertaining to key mechanisms implicated in the transition from steatosis and inflammation to fibrosis. Currently there are limited treatments for NASH although an increasing understanding of its pathogenesis will likely improve the development and use of interventions in the future.

Noise and vibration levels in artificial polar bear dens as related to selected petroleum exploration and developmental activities

International Nuclear Information System (INIS)

Blix, A.S.; Lentfer, J.W.

1992-01-01

Petroleum exploration and development are occurring in various locations in the Arctic, where there are important denning sites for polar bears. Petroleum activities usually coincide with winter denning activities by bears, who may abandon dens if subject to prolonged annoyance. A study was carried out to measure noise and vibration levels in artificial polar bear dens at Prudhoe's Bar, Alaska, resulting from seismic testing, drilling and transport. A microphone and an accelerometer were frozen to the floor of the dens, with leads passed through a consolidated snow filled entrance to a truck, tent or helicopter. Tests were carried out on land, sea ice, and next to a drilling tower on an artificial island, which was also used to measure noise levels resulting from a helicopter taking off. It was concluded that the dry and wind-beaten arctic snow muffles both sound and vibration extremely well, and it is unlikely that polar bears in their dens will be disturbed by the type of petroleum-related activities measured, provided they do not take place within 100 m of the dens. 8 refs., 7 figs., 1 tab

Corporate Social Responsibility i forsyningskæden

DEFF Research Database (Denmark)

Liempd, Dennis van

2007-01-01

Styring og kontrol af etiske risici i forsyningskæden som en del af virksomhedens samfundsansvar (corporate social re­sponsibility; CSR) er blevet mere og mere vigtig nu til dags. Der er stor national og international fokus på CSR-området, ikke mindst fordi globaliseringen har gjort, at flere...

Kapitalismens ånd og den kreative etik

DEFF Research Database (Denmark)

Stephensen, Jan Løhmann

Chiapellos tese om kapitalismens permanente behov for ny legitimering analyserer Jan Løhmann Stephensen nutidens koblinger mellem arbejde, kreativitet og økonomi som et svar på de kritikker af kapitalismen og lønarbejdet, som blev fremsat i anden halvdel af det 20. århundrede, typisk med den unge Karl Marx...

Hoffen auf den guten Willen – von der unverbindlichen Institutionalisierung feministischer Forderungen

Directory of Open Access Journals (Sweden)

Maike Bußmann

2008-11-01

Full Text Available Nachdem die Protagonistinnen der ersten Frauenbewegung prinzipiell den Zugang in die Institutionen erstritten hatten, wurde seit den 1968ern der Marsch durch die Institutionen angetreten. Diesen untersucht Stefanie Ehmsen für die Vereinigten Staaten und die Bundesrepublik, wobei sie die Unterschiede als Resultat der jeweiligen politischen Traditionen interpretiert. Zwar wartet sie mit gut recherchierten und lesenswerten Fallbeispielen auf, doch das Potential der Analyse wird leider nicht ausgeschöpft.

Open Access og Den Bibliometriske Forskningsindikator

DEFF Research Database (Denmark)

Dorch, Bertil

2011-01-01

I sine "Anbefalinger til implementering af Open Access i Danmark" foreslår det nationale Open Access Udvalget blandet andet, at Den Bibliometriske Forskningsindikator (BFI) bør koordineres med en national Open Access-politik. I dette paper, der er baseret på et blogindlæg, fremfører forfatteren...... fire grunde til, hvorfor han synes det er en dårlig idé at koble Open Access til BFI....

HyDEn: A Hybrid Steganocryptographic Approach for Data Encryption Using Randomized Error-Correcting DNA Codes

Directory of Open Access Journals (Sweden)

Dan Tulpan

2013-01-01

Full Text Available This paper presents a novel hybrid DNA encryption (HyDEn approach that uses randomized assignments of unique error-correcting DNA Hamming code words for single characters in the extended ASCII set. HyDEn relies on custom-built quaternary codes and a private key used in the randomized assignment of code words and the cyclic permutations applied on the encoded message. Along with its ability to detect and correct errors, HyDEn equals or outperforms existing cryptographic methods and represents a promising in silico DNA steganographic approach.

Den historiske roman for børn

DEFF Research Database (Denmark)

Skyggebjerg, Anna Karlskov

Bogen indeholder en redegørelse for den historiske roman som børnelitterær genre. Genren diskuteres i et teoretisk, historisk og analytisk perspektiv. Bogen afsluttes med en række principielle didaktiske overvejelser. Bogen er henvendt til alle, der beskæftiger sig professionelt med børnelitteratur...

Hemmelig ransagning og brevstandsning i den digitale virkelighed

DEFF Research Database (Denmark)

Lentz, Lene Wacher

2016-01-01

Artiklen tager udgangspunkt i sager om databedrageri, hvor betalingskort misbruges til køb på internettet. Politiets adgang til private chatfora på nettet analyseres i forhold til de straffeprocessuelle tvangsindgreb hemmelig ransagning, aflytning og dataaflæsning. Desuden behandler artiklen den ...

Perge'den iki Procurator Yazıtı

OpenAIRE

Onur, Fatih

2008-01-01

Perge'den iki Procurator Yazıtı Kısa bir süre önce Aşkım Özdizbay Perge'den iki adet Latince yazıtın kopyasını ve çevirisini, Prof. Dr. Haluk Abbasoğlu için hazırladıkları armağan kitabında yayımlamıştır. Verdiği bilgilere göre, bu yazıtlar 2004 – 2005 yılları Perge kazılarında, bir silmeli kaide üzerine sonradan yerleştirilmiş olarak ele geçmiştir. T. Claudius Plocamus'un onurlandırmalarını içeren metinler üzerine yapılan kısa bir araştırma ve sonuçlarının I.v.Perge (IK 54)�...

Enhancement of ultraviolet-DNA repair in denV gene transfectants and T4 endonuclease V-liposome recipients

International Nuclear Information System (INIS)

Kibitel, J.T.; Yee, V.; Yarosh, D.B.

1991-01-01

The phage T4 denV gene, coding for the pyrimidine-dimer specific T4 endonuclease V, was transfected into human repair-proficient fibroblasts, repair-deficient xeroderma pigmentosum fibroblasts, and wild type CHO hamster cells. Transfectants maintained denV DNA and expressed denV mRNA. Purified T4 endonuclease V encapsulated in liposomes was also used to treat repair-proficient and -deficient human cells. The denV transfected clones and liposome-treated cells showed increased unscheduled DNA synthesis and enhanced removal of pyrimidine dimers compared to controls. Both denV gene transfection and endonuclease V liposome treatment enhanced post-UV survival in xeroderma pigmentosum cells but had no effect on survival in repair-proficient human or hamster cells. The results demonstrate that an exogenous DNA repair enzyme can correct the DNA repair defect in xeroderma pigmentosum cells and enhance DNA repair in normal cells. (author)

Dressing the Black Body. Mode, Hairstyle und Schwarzsein in den USA – von den 1970er-Jahren bis zu Barack Obama

Directory of Open Access Journals (Sweden)

Philipp Dorestal

2017-08-01

Full Text Available Conventional forms of African American activism and organization in the second half of the twentieth century have been the subject of academic research for quite some time, but less attention has been devoted to symbolic and body political forms of intervention. Looking at the Afro hairstyle and hip hop culture, this article explores how African American identity has been reflected through Style Politics. It outlines the history of African American hairstyles from the 1970s until the 2000s and identifies elements of popular culture such as Blaxploitation movies and rap music as constitutive of African American fashion. The question of ›respectability‹ that surfaced in the context of racist discourses about black women will be examined through the example of First Lady Michelle Obama, who rose to fame as a fashion icon. In conclusion, the article discusses the case of Trayvon Martin, an African American teenager who was killed in 2012 while wearing a hoodie, making the garment once again an object of contention and a symbol of protest. * * * Klassische Formen des Aktivismus und der Organisierung von African Americans in der zweiten Hälfte des 20. Jahrhunderts sind schon seit geraumer Zeit Gegenstand wissenschaftlicher Studien. In der bisherigen Forschung weniger gewürdigt wurden jedoch symbolische und körperpolitische Interventionsformen. Dieser Aufsatz geht anhand der Afro-Frisur und der durch die Hip-Hop-Kultur inspirierten Mode der Frage nach, wie afroamerikanische Identität über Style Politics verhandelt wurde. Skizziert wird die Geschichte afroamerikanischer Hairstyles von den 1970er- bis zu den 2000er-Jahren. Weiterhin werden Elemente der Populärkultur wie das Blaxploitation-Kino oder die seit den 1980er-Jahren verbreitete Rap-Musik als stilbildend für afroamerikanische Modephänomene identifiziert. Die Frage der »Respektabilität«, die im Kontext rassistischer Diskurse über schwarze Frauen auftauchte, wird anhand von Michelle

Q fever in pregnant Goats: PAthogenesis and excretion of Coxiella burnetii

NARCIS (Netherlands)

Roest, H.I.J.; Gelderen, van E.; Dinkla, A.; Frangoulidis, D.; Zijderveld, van F.G.; Rebel, J.M.J.; Keulen, van L.J.M.

2012-01-01

Coxiella burnetii is an intracellular bacterial pathogen that causes Q fever. Infected pregnant goats are a major source of human infection. However, the tissue dissemination and excretion pathway of the pathogen in goats are still poorly understood. To better understand Q fever pathogenesis, we

Farvel til den privatpraktiserende lærer?

DEFF Research Database (Denmark)

Heilesen, Simon; Nielsen, Jørgen Lerche

2005-01-01

Artiklens forfattere fremlægger nogle bud på, hvorledes undervisere vil kunne engagere sig i gensidigt understøttende samarbejde, når de benytter samarbejds- og e-læringssystemer. Det forudsætter, at vi er parate til at revidere den traditionelle position, hvor vi som lærere alene og isoleret stå...

Habitat characteristics at den sites of the Point Arena mountain beaver (Aplodontia rufa nigra)

Science.gov (United States)

William J. Zielinski; John E. Hunter; Robin Hamlin; Keith M. Slauson; M. J. Mazurek

2010-01-01

The Point Arena mountain beaver (Aplodontia rufa nigra) is a federally listed endangered species, but has been the subject of few studies. Mountain beavers use burrows that include a single subterranean den. Foremost among the information needs for this subspecies is a description of the above-ground habitat features associated with dens. Using...

Teopæd-opgaven og den fagdidaktiske udfordring

DEFF Research Database (Denmark)

Hobel, Peter

2014-01-01

Artiklen diskuterer nødvendigheden af at styrke det fagdidaktiske perspektiv i 'teopæd-opgaven' - den opgave, som gymnasielærere i uddannelsesstilling skriver ved slutningen af året i uddannelsesstillingen. Artiklen diskuterer, hvad fag er, hvad forholdet er mellem almendidaktik og fagdidaktik, o...

Successful Ultra-Conservative Management of a Mandibular Premolar with Dens Invaginatus.

Science.gov (United States)

Abazarpour, Ramin; Parirokh, Masoud; Farhadi, Aida; Jalali, Zahra; Kheirabadi, Nasir

2017-01-01

Dens invaginatus is one of the most common anomalies of tooth structure. It is caused by the invagination of the crown surface during odontogenesis that enters the pulp chamber of the affected tooth. Depending on the complexity of invagination, the tooth might present with pulp necrosis, open apex and a complicated root canal system. This case report presents an Oehlers' type 2 dens-invaginatus in a mandibular premolar with chronic apical abscess. In most cases, dens invaginatus is removed during treatment. However, in this case report, based on cone-beam computed tomography (CBCT) evaluation, non-surgical treatment and maintenance of the invaginated segment was chosen in order to prevent compromising the tooth structure and its susceptibility to future root fracture. This is a new treatment approach and has not been performed in previous reports. Calcium-enriched mixture (CEM) cement was used as an apical plug followed by gutta-percha in warm vertical compaction for root canal obturation. The case was followed up for 36 months after treatment. This report highlights the importance of selecting the appropriate treatment approach based on CBCT evaluation.

Molecular Pathogenesis of Neuromyelitis Optica

Science.gov (United States)

Bukhari, Wajih; Barnett, Michael H; Prain, Kerri; Broadley, Simon A

2012-01-01

Neuromyelitis optica (NMO) is a rare autoimmune disorder, distinct from multiple sclerosis, causing inflammatory lesions in the optic nerves and spinal cord. An autoantibody (NMO IgG) against aquaporin-4 (AQP4), a water channel expressed on astrocytes is thought to be causative. Peripheral production of the antibody is triggered by an unknown process in genetically susceptible individuals. Anti-AQP4 antibody enters the central nervous system (CNS) when the blood brain barrier is made permeable and has high affinity for orthogonal array particles of AQP4. Like other autoimmune diseases, Th17 cells and their effector cytokines (such as interleukin 6) have been implicated in pathogenesis. AQP4 expressing peripheral organs are not affected by NMO IgG, but the antibody causes extensive astrocytic loss in specific regions of the CNS through complement mediated cytotoxicity. Demyelination occurs during the inflammatory process and is probably secondary to oligodendrocyte apoptosis subsequent to loss of trophic support from astrocytes. Ultimately, extensive axonal injury leads to severe disability. Despite rapid advances in the understanding of NMO pathogenesis, unanswered questions remain, particularly with regards to disease mechanisms in NMO IgG seronegative cases. Increasing knowledge of the molecular pathology is leading to improved treatment strategies. PMID:23202933

Pathogenesis of Focal Segmental Glomerulosclerosis

Directory of Open Access Journals (Sweden)

Beom Jin Lim

2016-11-01

Full Text Available Focal segmental glomerulosclerosis (FSGS is characterized by focal and segmental obliteration of glomerular capillary tufts with increased matrix. FSGS is classified as collapsing, tip, cellular, perihilar and not otherwise specified variants according to the location and character of the sclerotic lesion. Primary or idiopathic FSGS is considered to be related to podocyte injury, and the pathogenesis of podocyte injury has been actively investigated. Several circulating factors affecting podocyte permeability barrier have been proposed, but not proven to cause FSGS. FSGS may also be caused by genetic alterations. These genes are mainly those regulating slit diaphragm structure, actin cytoskeleton of podocytes, and foot process structure. The mode of inheritance and age of onset are different according to the gene involved. Recently, the role of parietal epithelial cells (PECs has been highlighted. Podocytes and PECs have common mesenchymal progenitors, therefore, PECs could be a source of podocyte repopulation after podocyte injury. Activated PECs migrate along adhesion to the glomerular tuft and may also contribute to the progression of sclerosis. Markers of activated PECs, including CD44, could be used to distinguish FSGS from minimal change disease. The pathogenesis of FSGS is very complex; however, understanding basic mechanisms of podocyte injury is important not only for basic research, but also for daily diagnostic pathology practice.

Pathogenesis of oral FIV infection.

Directory of Open Access Journals (Sweden)

Craig Miller

Full Text Available Feline immunodeficiency virus (FIV is the feline analogue of human immunodeficiency virus (HIV and features many hallmarks of HIV infection and pathogenesis, including the development of concurrent oral lesions. While HIV is typically transmitted via parenteral transmucosal contact, recent studies prove that oral transmission can occur, and that saliva from infected individuals contains significant amounts of HIV RNA and DNA. While it is accepted that FIV is primarily transmitted by biting, few studies have evaluated FIV oral infection kinetics and transmission mechanisms over the last 20 years. Modern quantitative analyses applied to natural FIV oral infection could significantly further our understanding of lentiviral oral disease and transmission. We therefore characterized FIV salivary viral kinetics and antibody secretions to more fully document oral viral pathogenesis. Our results demonstrate that: (i saliva of FIV-infected cats contains infectious virus particles, FIV viral RNA at levels equivalent to circulation, and lower but significant amounts of FIV proviral DNA; (ii the ratio of FIV RNA to DNA is significantly higher in saliva than in circulation; (iii FIV viral load in oral lymphoid tissues (tonsil, lymph nodes is significantly higher than mucosal tissues (buccal mucosa, salivary gland, tongue; (iv salivary IgG antibodies increase significantly over time in FIV-infected cats, while salivary IgA levels remain static; and, (v saliva from naïve Specific Pathogen Free cats inhibits FIV growth in vitro. Collectively, these results suggest that oral lymphoid tissues serve as a site for enhanced FIV replication, resulting in accumulation of FIV particles and FIV-infected cells in saliva. Failure to induce a virus-specific oral mucosal antibody response, and/or viral capability to overcome inhibitory components in saliva may perpetuate chronic oral cavity infection. Based upon these findings, we propose a model of oral FIV pathogenesis

Persistent perineal sinus. Incidence, pathogenesis, risk factors, and management

International Nuclear Information System (INIS)

Lohsiriwat, V.

2009-01-01

This review discusses the incidence, pathogenesis, risk factors, diagnosis, and therapeutic options for persistent perineal sinus (PPS), defined as a perineal wound that remains unhealed more than 6 months after surgery. The incidence of PPS after surgery for inflammatory bowel disease (IBD) ranges from 3% to 70% and after abdominoperineal resection (APR) for Low rectal cancer, it can be up to 30%. These unhealed wounds are frequently related to perioperative pelvic or perineal sepsis. Crohn's disease (CD) and neoadjuvant radiation therapy are also important risk factors. The management of PPS is based on an understanding of pathogenesis and clinical grounds. The advantages and disadvantages of the current therapeutic approaches, including the topical administration of various drugs, vacuum-assisted closure, and perineal reconstruction with a muscle flap or a myocutaneous flap are also discussed. (author)

Schulze and Brand type a-IV dens invaginatus with radicular cyst: A rare case report

Directory of Open Access Journals (Sweden)

Rachita Chengappa

2015-01-01

Full Text Available Though a clinical examination may reveal a deep fissure or pit on the surface of an anterior tooth, radiographic examination is a more accurate approach to diagnose an invagination. Dens invaginatus is one of the common dental deformities, but the defect involving the root and its association with radicular cyst is still very uncommon. The objective of this case presentation is to report a case of radicular dens in dente, which is a rare dental anomaly. This case report shows that dens invaginatus with an open apex and a radicular cyst can be treated successfully using currently available materials.

Inflammatory bowel diseases (IBD) - critical discussion of etiology, pathogenesis, diagnostics, and therapy; Chronisch entzuendliche Darmerkrankungen - Kritische Diskussion von Aetiologie, Pathogenese, Diagnostik und Therapie

Energy Technology Data Exchange (ETDEWEB)

Ochsenkuehn, T.; Sackmann, M.; Goeke, B. [Medizinische Klinik II, Klinikum der Universitaet Muenchen-Grosshadern (Germany)

2003-01-01

Aims Crohn's disease and ulcerative colitis are the most frequent inflammatory bowel diseases (IBD) with a prevalence of approximately one out of 500.Cytokine research opened new and potent treatment options and thus stimulated clinical and basic research.However, the IBD still remain a challenge for patients and physicians,demanding close cooperation between gastroenterologists,radiologists and surgeons.The basic understanding of IBD,which is necessary for efficient diagnostic and therapeutic concepts is reviewed. Based upon recent publications and our clinical experience we discuss aspects of etiology,pathogenesis,diagnostics,and therapy of Crohn's disease and ulcerative colitis. A genetically influenced, exaggerated and sustained immune response against the own gut flora seems to be one of the most important factors in the pathogenesis of IBD.Not less important are environmental influences.For instance, cigarette smoking had been judged to have some negative influence on the natural course of Crohn's disease.Now,however, recent studies show that smoking is even a significant independent risk factor in the pathogenesis of IBD. Since IBD and especially Crohn's disease can effect the whole body, detailed analysis of inflammatory organ involvement is necessary before therapy.For instance, the MRIenteroclysis technique adds a necessary diagnostic tool for the exploration of those parts of the small bowel that cannot been reached by routine endoscopy like the upper ileum and the lower jejunum. In terms of therapy, a change of paradigms can be observed: patients will no longer be treated only when symptoms arise, but will early be integrated into a therapeutic concept, which is determined by site and extent of the disease and adapted to the abilities and needs of the patient.Furthermore,immunosuppressive agents like azathioprine and 6-mercaptopurine will establish as central concept in the medical treatment of IBD.Discussion IBD-therapy should

Den enkeltes livsmuligheder i fællesskaber

DEFF Research Database (Denmark)

Schwartz, Ida

2012-01-01

for selvbestemmelse og individuelle valg, har i nogen grad skygget for en opmærksomhed på, at mennesker alment betragtet er afhængige af at være en del af sociale fællesskaber (Engen, 2009). Artiklen bygger på den grundantagelse, at vi alle realiserer det gode liv for os selv gennem vores deltagelse i sociale...

Remote identification of potential polar bear maternal denning habitat in northern Alaska using airborne LiDAR

Science.gov (United States)

Jones, B. M.; Durner, G. M.; Stoker, J.; Shideler, R.; Perham, C.; Liston, G. E.

2013-12-01

Polar bear (Ursus maritimus) populations throughout the Arctic are being threatened by reductions in critical sea ice habitat. Throughout much of their range, polar bears give birth to their young in winter dens that are excavated in snowdrifts. New-born cubs, which are unable to survive exposure to Arctic winter weather, require 2-3 months of the relatively warm, stable, and undisturbed environment of the den for their growth. In the southern Beaufort Sea (BS), polar bears may den on the Alaskan Arctic Coastal Plain (ACP).The proportion of dens occurring on land has increased because of reductions in stable multi-year ice, increases in unconsolidated ice, and lengthening of the fall open-water period. Large portions of the ACP are currently being used for oil and gas activities and proposed projects will likely expand this footprint in the near future. Since petroleum exploration and development activities increase during winter there is the potential for human activities to disturb polar bears in maternal dens. Thus, maps showing the potential distribution of terrestrial denning habitat can help to mitigate negative interactions. Prior remote sensing efforts have consisted of manual interpretation of vertical aerial photography and automated classification of Interferometric Synthetic Aperture (IfSAR) derived digital terrain models (DTM) (5-m spatial resolution) focused on the identification of snowdrift forming landscape features. In this study, we assess the feasibility of airborne Light Detection and Ranging (LiDAR) data (2-m spatial resolution) for the automated classification of potential polar bear maternal denning habitat in a 1,400 km2 area on the central portion of the ACP. The study region spans the BS coast from the Prudhoe Bay oilfield in the west to near Point Thompson in the east and extends inland from 10 to 30 km. Approximately 800 km2 of the study area contains 19 known den locations, 51 field survey sites with information on bank height and

How can macroscopically normal peritoneum contribute to the pathogenesis of endometriosis?

Science.gov (United States)

Fassbender, Amelie; Overbergh, Lut; Verdrengh, Eefje; Kyama, Cleophas M; Vodolazakaia, Alexandra; Bokor, Attila; Meuleman, Christel; Peeraer, Karen; Tomassetti, Carla; Waelkens, Etienne; Mathieu, Chantal; D'Hooghe, Thomas

2011-09-01

This study indicates that the immunobiology of macroscopically normal peritoneum is relevant to understand the pathogenesis of endometriosis. Peritoneal interleukin 6, interleukin 12, and ferritin were differentially expressed in women with and without endometriosis. Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Den danske ROSE-undersøgelse

DEFF Research Database (Denmark)

Andersen, Annemarie Møller; Allerup, Peter; Arnvig, Birgitte

ROSE (Relevance of Science Education) er en international komparativ undersøgelse af 15-åriges holdninger til og interesse for naturfagsundervisning, naturvidenskab og teknologi med deltagelse af ca. 40. lande. Dataindsamlingen til den danske del af ROSE-undersøgelsen blev gennemført i 2003....... Antologien giver et overblik over  og forskellige perspektiver på de danske 15-åriges besvarelser af de ca. 280 spørgsmål i det danske ROSE-skema....

Genome-wide association studies on HIV susceptibility, pathogenesis and pharmacogenomics

Directory of Open Access Journals (Sweden)

van Manen Daniëlle

2012-08-01

Full Text Available Abstract Susceptibility to HIV-1 and the clinical course after infection show a substantial heterogeneity between individuals. Part of this variability can be attributed to host genetic variation. Initial candidate gene studies have revealed interesting host factors that influence HIV infection, replication and pathogenesis. Recently, genome-wide association studies (GWAS were utilized for unbiased searches at a genome-wide level to discover novel genetic factors and pathways involved in HIV-1 infection. This review gives an overview of findings from the GWAS performed on HIV infection, within different cohorts, with variable patient and phenotype selection. Furthermore, novel techniques and strategies in research that might contribute to the complete understanding of virus-host interactions and its role on the pathogenesis of HIV infection are discussed.

Køn og kærlighed i Den Hebraiske Bibel og tidlig rabbinsk litteratur

DEFF Research Database (Denmark)

Schleicher, Marianne

2014-01-01

De religiøse grundlæggertekster synes optaget af at sikre kulturens videreførelse gennem entydiggørelse af køn og kærlighed, men den hebræiske bibel og den tidlige rabbinske litteratur skildrer lige så ofte i de mest dramatiske og poetiske passager køn og kærlighed som komplekse, sammensatte, for...

Molecular Pathogenesis of NASH

Directory of Open Access Journals (Sweden)

Alessandra Caligiuri

2016-09-01

Full Text Available Nonalcoholic steatohepatitis (NASH is the main cause of chronic liver disease in the Western world and a major health problem, owing to its close association with obesity, diabetes, and the metabolic syndrome. NASH progression results from numerous events originating within the liver, as well as from signals derived from the adipose tissue and the gastrointestinal tract. In a fraction of NASH patients, disease may progress, eventually leading to advanced fibrosis, cirrhosis and hepatocellular carcinoma. Understanding the mechanisms leading to NASH and its evolution to cirrhosis is critical to identifying effective approaches for the treatment of this condition. In this review, we focus on some of the most recent data reported on the pathogenesis of NASH and its fibrogenic progression, highlighting potential targets for treatment or identification of biomarkers of disease progression.

En referenceramme til analyse af en detailkæde og strukturen i dens branche

DEFF Research Database (Denmark)

Skytte, Hans

2001-01-01

identitet, dens opfattelser og fortolkning af mar-kedet og konkurrencesituationen, samt relationer over til dens strukturer, sortiment og salgsadfærd. Analysen vil kunne gennemføres på et bestemt tidspunkt og således give et øjebliksbillede af en detailkæde, eller den kan gennemføres flere på hinanden...... følgende gange, hvorved man kan opnå en analyse af sammenhænge i udviklingen i de faktorer, der indgår i analysen. Ved udviklingen af analyserammen er der tænkt på en europæisk fødevaredetailkæde, men rammen kan lige så godt anvendes på en detailkæde, der distribuerer modetøj eller møbler. Analyserammen...

Optimal matching of energy supply and demand; Optimale Anpassung der Energiebereitstellung an den Bedarf

Energy Technology Data Exchange (ETDEWEB)

Baumgarth, S. [Competence Center for Building Networks in Wolfenbuettel (Germany); Boggasch, E.; Heiser, M.; Schernus, G.P. [Fachhochschule Braunschweig/Wolfenbuettel (Germany)

2004-06-01

New strategies are presented for matching heat supply and demand on the basis of a bus technology. Investment costs are at a minimum as the automation stations are activated by introducing new programs. (orig.) [German] Seit einiger Zeit wird ueber verschiedene Regelungsstrategien versucht, die Energiebereitstellung so an den Bedarf (Verbraucher) anzupassen, dass die Waermeverluste beim Transport auf den Zuleitungen sowie in der Energiezentrale minimiert werden. Fuer mehrere Anwendungen aus dem Bereich der Heizungs-, Lueftungs- und Klimatechnik sollen hier neue Strategien vorgestellt werden, die erst mit dem Einsatz der Bus-Technologien in der Gebaeudeautomation moeglich sind. Fuer die Betrachtungen ist es auch von Wichtigkeit, dass zu deren Umsetzung moeglichst keine zusaetzlichen Investitionskosten erforderlich sind, sondern dass die in den Automationsstationen durch Einfuegen neuer Programme zu aktivieren sind. (orig.)

Multifaktormodeller på den svenska marknaden - En studie av OMX Stockholm mellan 1996 och 2014

OpenAIRE

Hammarfrid, Peter; Henningsson, Tom

2015-01-01

Bakgrund:CAPM räcker i flera tillfällen inte till för att estimera framtida avkastning. Vissa av prisavvikelsernafrån CAPM är väldokumenterade och har bestått över tid, vilket har lett till uppkomsten avkorrigerande faktorer. En modell som använder sig av två sådana korrigerande faktorer är Fama ochFrenchs tre-faktormodell. Den har testats flertalet gånger på den svenska marknaden där den visat gehögre förklaringsgrader än CAPM. År 2012 samt år 2014 presenterades två nya multifaktormodeller,s...

The Possible HEPATOPROTECTIVE Effect Of Taurine In Diethyl Nitrosamine (DEN) Treated Rats

International Nuclear Information System (INIS)

SHAROUD, M.N.M.; ABD EL-MONEIM, A.E.

2009-01-01

Egypt occupies a progressed rank among the developing countries in prevalence of hepatic diseases and liver disorders. Hepatopathies are major public health problems in Egypt where hepatitis C virus (HCV) and schistosomia record a high prevalence which may account for the most serious clinical disorders e.g. liver cirrhosis and liver cancer.Vascular endothelial growth factor (VEGF) is the most specific and potent mitogen of endothelial cells. Hepatocellular carcinoma (HCC) is characterized by increased pathologic angio genesis and increased level of the vascular endothelial growth factor. Taurine is clinically used as a protecting agent of the liver and recently, its chemo preventive effect on rat large bowel carcinogenesis was reported.In this study, forty male albino rats were used and diethyl nitrosamine (DEN) was used for inducing pathological changes in different organs while taurine was given to investigate the possible protective effects on liver tissue after DEN treatment.The results showed elevation in serum AST, ALT, ALP, urea, creatinine, cholesterol and triglycerides in DEN group. On the other hand, estimation of sex hormones exhibited marked decrease in testosterone and significant increase in estradiol levels in DEN group as compared to control and taurine groups.Pathological examination of rat liver showed that DEN induced peri portal inflammatory cellular infiltrate, piece meal necrosis and necro inflammatory activity as well as the appearance of areas of haemorrhage and ballooning in hepatocytes. Moreover, moderate to high expression of V EGF in the cytoplasm of hepatocytes and sinusoidal cells were clearly observed while in control and taurine groups, normal architecture of hepatic tissue of rats was found and normal distribution of V EGF as diffuse or focal granular cytoplasmic stain in rats liver were observed. The prophylactic group showed minimal and mild changes in the liver tissue with absence of necro inflammation and the V EGF expression

Barnehagen, læring og den nasjonale konkurranseevnen

DEFF Research Database (Denmark)

Krejsler, John B.

2013-01-01

, og som har røtter i reformpedagogikken, havner dermed under press. Dette gir konkurransestatens forestillinger om danning en fordel, som er mer inspirert av teorien om rasjonelle valg (rational choice theory), og som fokuserer på «den opportunistiske person» som gjennom livslang læring utvikler sin...

Hyekyung Cho: Chinas langer Marsch in den Kapitalismus

DEFF Research Database (Denmark)

Czeskleba-Dupont, Rolf

2006-01-01

Chos afhandling fra Berlin refereres i hovedtræk. Tre modsætninger tages op i den: 1) mellem 'transitionen' ind i kapitalismen og herredømmet af et kommunistisk parti, hvor det bl.a.viser sig at particentralen fremmer liberaliseringen i kampen mod statsvirksomhederne; 2) mellem integrationen i ve...

Den lille krig i fredstid. Danske militære erfaringer i Musa Qala i 2006

DEFF Research Database (Denmark)

Brink Rasmussen, Jakob

2018-01-01

Den 1. Lette Opklaringseskadron fra Bornholms forsvar af distriktscentret Musa Qala i den afghanske Helmand-provins i eftersommeren 2006 gennemanalyseres. Det sker med det formål at klarlægge, hvordan man udnyttede læring under forberedelsen til indsættelsen samt under og efter denne. Herunder da...

Animal Models of Zika Virus Infection, Pathogenesis, and Immunity.

Science.gov (United States)

Morrison, Thomas E; Diamond, Michael S

2017-04-15

Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that now causes epidemics affecting millions of people on multiple continents. The virus has received global attention because of some of its unusual epidemiological and clinical features, including persistent infection in the male reproductive tract and sexual transmission, an ability to cross the placenta during pregnancy and infect the developing fetus to cause congenital malformations, and its association with Guillain-Barré syndrome in adults. This past year has witnessed an intensive effort by the global scientific community to understand the biology of ZIKV and to develop pathogenesis models for the rapid testing of possible countermeasures. Here, we review the recent advances in and utility and limitations of newly developed mouse and nonhuman primate models of ZIKV infection and pathogenesis. Copyright © 2017 American Society for Microbiology.

Hvordan håndteres den nødvendige distribution af digital bevaring?

DEFF Research Database (Denmark)

Zierau, Eld

2014-01-01

Distribueret digital bevaring er nødvendig, men også tit vanskelig, især når flere organisationer er involveret. En referenceramme kan bistå til forståelse, opbygning og tjek af distribueret digital bevaring, så tilliden til den digitale bevaring opretholdes......Distribueret digital bevaring er nødvendig, men også tit vanskelig, især når flere organisationer er involveret. En referenceramme kan bistå til forståelse, opbygning og tjek af distribueret digital bevaring, så tilliden til den digitale bevaring opretholdes...

Genes, autoimmunity and pathogenesis of rheumatic heart disease

International Nuclear Information System (INIS)

Guilherme, L; Köhler, K F; Postol, E; Kalil, J

2011-01-01

Pathogenesis of rheumatic heart disease (RHD) remains incompletely understood. Several genes associated with RHD have been described; most of these are involved with immune responses. Single nucleotide polymorphisms in a number of genes affect patients with RHD compared to controls. Molecular mimicry between streptococcal antigens and human proteins, including cardiac myosin epitopes, vimentin and other intracellular proteins is central to the pathogenesis of RHD. Autoreactive T cells migrate from the peripheral blood to the heart and proliferate in the valves in response to stimulation with specific cytokines. The types of cells involved in the inflammation as well as different cytokine profiles in these patients are being investigated. High TNF alpha, interferon gamma, and low IL4 are found in the rheumatic valve suggesting an imbalance between Th1 and Th2 cytokines and probably contributing to the progressive and permanent valve damage. Animal model of ARF in the Lewis rat may further contribute towards understanding the ARF

Tendenser inden for den nyere fagsprogsforskning i Danmark

DEFF Research Database (Denmark)

Bergenholtz, Henning; Engberg, Jan

1995-01-01

I artiklen præsenteres hovedtendenserne i den fagsproglige forskning, der er foregået specielt med rod i handelshøjskolerne i Danmark i de seneste 25 år. Efter en indledning om fagsprogsbegreber og rammerne for fagsproglig forskning i Danmark præsenteres fagsproglige arbejder inden for områderne ...

Loyalitet i praksis:En etnologisk kulturanalyse af fænomenet den loyale forbruger

OpenAIRE

Breddam, Mads Dupont

2015-01-01

Loyalitet i praksis – en etnologisk kulturanalyse af fænomenet den loyale forbruger , er en kvalitativ kulturanalyse af, hvordan loyalitet skabes i forbindelse med den danske detailhandels - og andelsorganisation Coop og Coops loyalitetsprogram CoopPlus. Undersøgelserne bygger på et empirisk materiale , som hovedsageligt består af kvalitative interviews med en række medlemmer og medejere af Coop samt med medarbejdere i Coops hovedkvarter i Albertslund . Afhandlingen er en praksiografisk under...

Vom Fachwissen zur Handlungskompetenz - die Berufsschule vor den Herausforderungen des sozioökonomischen Strukturwandels

OpenAIRE

Kouli, Ekaterina

2006-01-01

Der sozioökonomische Wandel und die damit einhergehenden Veränderungen der Wirtschafts- und Beschäftigungsstrukturen stellen das Bildungssystem in Deutschland vor neuartige Herausforderungen. Wesentliche Momente dieses Wandels sind die technologische Entwicklung, die Globalisierung der Wirtschaft, der Übergang von der Industrie- zur Wissensgesellschaft sowie Veränderungen in den gesellschaftlichen Wertvorstellungen. Diese Entwicklungen verändern die Arbeitsprozesse in den Unternehmen und dami...

Den enes död, den andres bröd : En fallstudie i Fonus kriskommunikation

OpenAIRE

Orest Flavet, Sebastian

2014-01-01

Denna studie undersöker hur begravningsbyrån Fonus valde att bemöta en kritisk artikel, publicerad i Aftonbladet, med ett pressmeddelande som lades upp på den egna hemsidan. Uppsatsen undersöker först vilka retoriska verktyg som har använts i skapandet av detta meddelande, och sett från Benoits teori om Image Repair, vilka strategier som använts och hur användningen av dessa har sett ut. Därefter söker studien att praktiskt undersöka detta budskap genom att låta en utvald grupp respondenter t...

Begrundelser for ytringsfriheden og dens grænser

DEFF Research Database (Denmark)

Lægaard, Sune

2007-01-01

såkaldte skadesprincip, der ofte antages at udelukke den type begrænsninger af ytringsfriheden, som fx findes i racismeparagraffen. Skadesprincippet udelukker dog ikke sådanne begrænsninger, men en fuld retfærdiggørelse af dem kræver en bredere begrundelse, og anerkendelse af minoriteters ligeværd...

Osteoblast role in osteoarthritis pathogenesis.

Science.gov (United States)

Maruotti, Nicola; Corrado, Addolorata; Cantatore, Francesco P

2017-11-01

Even if osteoarthritis pathogenesis is still poorly understood, numerous evidences suggest that osteoblasts dysregulation plays a key role in osteoarthritis pathogenesis. An abnormal expression of OPG and RANKL has been described in osteoarthritis osteoblasts, which is responsible for abnormal bone remodeling and decreased mineralization. Alterations in genes expression are involved in dysregulation of osteoblast function, bone remodeling, and mineralization, leading to osteoarthritis development. Moreover, osteoblasts produce numerous transcription factors, growth factors, and other proteic molecules which are involved in osteoarthritis pathogenesis. © 2017 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc.

Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advances

Science.gov (United States)

Dhanasekaran, Renumathy; Bandoh, Salome; Roberts, Lewis R.

2016-01-01

Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality and has an increasing incidence worldwide. HCC can be induced by multiple etiologies, is influenced by many risk factors, and has a complex pathogenesis. Furthermore, HCCs exhibit substantial heterogeneity, which compounds the difficulties in developing effective therapies against this highly lethal cancer. With advances in cancer biology and molecular and genetic profiling, a number of different mechanisms involved in the development and progression of HCC have been identified. Despite the advances in this area, the molecular pathogenesis of hepatocellular carcinoma is still not completely understood. This review aims to elaborate our current understanding of the most relevant genetic alterations and molecular pathways involved in the development and progression of HCC, and anticipate the potential impact of future advances on therapeutic drug development. PMID:27239288

Über den Nachrichtenwert von Friedensjournalismus - Ergebnisse einer experimentellen Studie

Directory of Open Access Journals (Sweden)

Monika Spohrs

2006-04-01

Full Text Available Laut Nachrichtenwertforschung hängt die Publikations- und Lesenswürdigkeit von Nachrichtentexten von den Nachrichtenfaktoren der zu publizierenden Ereignisse ab. Als anerkannte Nachrichtenfaktoren gelten beispielsweise Negativität, Vereinfachung und Personifizierung. Friedensjournalistische Arbeiten weichen von diesen Kriterien oft ab, indem sie versuchen, die berichteten Ereignisse in ihrer Komplexität darzustellen, den Fokus nicht auf negative Ereignisse zu legen und auch strukturellen Themen Raum zu geben. Aber sind sie deshalb weniger publikationswürdig? Der folgende Artikel zeigt anhand einer experimentellen Studie, welche Akzeptanz Friedensjournalismus beim Leser finden kann, auch wenn dies teilweise den Theorien der Nachrichtenwertforschung widerspricht. Des weiteren wird gezeigt, wie sich konstruktive Berichterstattung auf die mentalen Modelle der Rezipienten auswirkt und in welchem Zusammenhang diese beiden Ergebnisse miteinander stehen. In der vorliegenden Studie wurden einer für die Leserschaft der deutschen Qualitätspresse hinsichtlich Alter und Bildungsgrad repräsentativen Stichprobe von n = 128 Versuchspersonen Zeitungsartikel zu drei verschiedenen Ereignissen im Konfliktfeld des ehemaligen Jugoslawien dargeboten. Zu jedem Ereignis wurden vier verschiedene Textvarianten verwendet: eine gemäßigt eskalationsorientierte Originalfassung aus einer deutschen Qualitätszeitung (Die Welt, Frankfurter Allgemeine Zeitung, Süddeutsche Zeitung und drei modifizierte Versionen dieser Artikel, (a mit gemäßigt deeskalations-orientiertem Framing, (b mit stark deeskalationsorientiertem Framing und (c mit einer Verschärfung der Eskalationsorientierung der dargestellten Konflikte. Die Aufgabe der Vpn bestand darin, zu jedem der drei Ereignisse eine Textvariante zu lesen und danach in eigenen Worten schriftlich wiederzugeben und anschließend einen Fragebogen zu Akzeptanz, Glaubwürdigkeit, Ausgewogenheit, Neuigkeitsgehalt, Bewertung und

The pathogenesis of Ebola hemorrhagic fever.

Science.gov (United States)

Takada, A; Kawaoka, Y

2001-10-01

Ebola virus causes lethal hemorrhagic disease in humans, yet there are still no satisfactory biological explanations to account for its extreme virulence. This review focuses on recent findings relevant to understanding the pathogenesis of Ebola virus infection and developing vaccines and effective therapy. The available data suggest that the envelope glycoprotein and the interaction of some viral proteins with the immune system are likely to play important roles in the extraordinary pathogenicity of this virus. There are also indications that genetically engineered vaccines, including plasmid DNA and viral vectors expressing Ebola virus proteins, and passive transfer of neutralizing antibodies could be feasible options for the control of Ebola virus-associated disease.

Cloud computing og den strafferetlige beskyttelse af data

DEFF Research Database (Denmark)

Mathiasen, Peter Dueholm

2013-01-01

Cloud computing er blevet en populær metode for bl.a. at opbevare data. Muligheden for eksempelvis at placere forretningskritiske data på teknisk udstyr, som ejes af den udbyder, der driver cloud computing tjenesten, gør det aktuelt at forholde sig til, om straffeloven i sådanne tilfælde yder et...

Den Pædagogiske Refleksionsmodel som sammenhængskraft

DEFF Research Database (Denmark)

Voergaard Poulsen, Bettina; Lucht, Camill; Vibholm Persson, Stine

Den Pædagogiske Refleksions Model (PRM) illustrerer de vidensdimensioner, der indgår i en kvalificeret klinisk beslutning. I projektet 'Sammenhæng på TVÆRS i fremtidens sygeplejeuddannelse (PÅ TVÆRS)" indgår PRM som pædagogisk greb. Der undersøges om PRM skaber sammenhæng for studerendes læring i...

Rum, rammer og biblioteker i den virtuelle verden

DEFF Research Database (Denmark)

Heilesen, Simon

2009-01-01

Med udgangspunkt i en kort introduktion til hvordan rum og rammer gestaltes i den virtuelle 3‐D verden Second Life, undersøger denne artikel, på hvilke måder rum og rammesætning anvendes og opleves i en faglig sammenhæng. Som eksempel anvendes det danske biblioteksprojekt i Second Life, Info Island...

Den fjerde vej: Trumps sejr skaber ny samfundsorden

DEFF Research Database (Denmark)

Rasmussen, Martin Møller Boje; Andersen, Torben K.; Kragh, Claus

2016-01-01

Bag Donald Trumps uempatiske retorik gemmer sig omridset af et politisk projekt, man kan kalde den fjerde vej. USA’s kommende præsident blander højre- og venstreorienterede mærkesager til et nyt nationalsocialt politisk koncept. Spørgsmålet er, om Trumps fjerde vej er et seriøst bud på en ny...

Om den sociale og symbolske funktion af uddannelsesevalueringer

DEFF Research Database (Denmark)

Nørholm, Morten

Afhandlingens teoretiske udgangspunkt er hos Émile Durkheim, Pierre Bourdieu, Ulf P. Lund­gren, Staf Callewaert, det konkrete er en række evalueringer af uddannelser til (semi)professioner inden for sundhedssektoren.                I afhandlingen konstrueres den sociale og symbolske funktion af...

Kommunen er død - længe leve den digitale disruption

DEFF Research Database (Denmark)

Andersen, Kim Normann

2017-01-01

"New Public Management is Dead. Long Live the Digital Era." Sådan proklamerede Patrick Donleavy digitaliseringens muligheder i en banebrydende artikel fra 2005. Med en omskrivning af dette citat til "Kommunen er død, længe leve den digitale disruption", er ballet åbnet for denne artikel......."New Public Management is Dead. Long Live the Digital Era." Sådan proklamerede Patrick Donleavy digitaliseringens muligheder i en banebrydende artikel fra 2005. Med en omskrivning af dette citat til "Kommunen er død, længe leve den digitale disruption", er ballet åbnet for denne artikel....

Genfortryllelse i den digitale tidsalder

DEFF Research Database (Denmark)

Madsen, Theis Vallø

, hvilket bl.a. kommer til udtryk i en ny vinylplade- og polaroidbillede-interesse. Denne undersøgelse går tilbage til begyndelsen af oplysningstiden, op igennem det 20. århundrede og frem til vores digitale kultur for at beskrive baggrunden og forestillingerne bag denne form for “analog æstetik”.......I den digitale tidsalder bliver uhyre mængder af information, billeder og musik noget nær frit tilgængelige, uendeligt reproducérbare og frigjort fra sit ”her” og ”nu”. I samme stund er der opstået en fornyet interesse for artefakter, der er stoflige, håndgribelige og u- eller anti-digitale...

Good-Practice-Ansätze für den Dienstleistungseinkauf

OpenAIRE

Hänsel, Martin; Hofmann, Erik

2017-01-01

Die Performance Excellence Studie des Lehrstuhls für Logistikmanagement der Hochschule St. Gallen (HSG) zeigt auf, was moderne Unternehmen tun müssen, wenn sie den Einkauf von Dienstleistungen zeitgemäss handhaben wollen.

Pathogenesis of Idiopathic Pulmonary Fibrosis

Science.gov (United States)

Wolters, Paul J.; Collard, Harold R.; Jones, Kirk D.

2014-01-01

Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial lung disease associated with aging that is characterized by the histopathological pattern of usual interstitial pneumonia. Although an understanding of the pathogenesis of IPF is incomplete, recent advances delineating specific clinical and pathologic features of IPF have led to better definition of the molecular pathways that are pathologically activated in the disease. In this review we highlight several of these advances, with a focus on genetic predisposition to IPF and how genetic changes, which occur primarily in epithelial cells, lead to activation of profibrotic pathways in epithelial cells. We then discuss the pathologic changes within IPF fibroblasts and the extracellular matrix, and we conclude with a summary of how these profibrotic pathways may be interrelated. PMID:24050627

Modeling TH 2 responses and airway inflammation to understand fundamental mechanisms regulating the pathogenesis of asthma.

Science.gov (United States)

Foster, Paul S; Maltby, Steven; Rosenberg, Helene F; Tay, Hock L; Hogan, Simon P; Collison, Adam M; Yang, Ming; Kaiko, Gerard E; Hansbro, Philip M; Kumar, Rakesh K; Mattes, Joerg

2017-07-01

In this review, we highlight experiments conducted in our laboratories that have elucidated functional roles for CD4 + T-helper type-2 lymphocytes (T H 2 cells), their associated cytokines, and eosinophils in the regulation of hallmark features of allergic asthma. Notably, we consider the complexity of type-2 responses and studies that have explored integrated signaling among classical T H 2 cytokines (IL-4, IL-5, and IL-13), which together with CCL11 (eotaxin-1) regulate critical aspects of eosinophil recruitment, allergic inflammation, and airway hyper-responsiveness (AHR). Among our most important findings, we have provided evidence that the initiation of T H 2 responses is regulated by airway epithelial cell-derived factors, including TRAIL and MID1, which promote T H 2 cell development via STAT6-dependent pathways. Further, we highlight studies demonstrating that microRNAs are key regulators of allergic inflammation and potential targets for anti-inflammatory therapy. On the background of T H 2 inflammation, we have demonstrated that innate immune cells (notably, airway macrophages) play essential roles in the generation of steroid-resistant inflammation and AHR secondary to allergen- and pathogen-induced exacerbations. Our work clearly indicates that understanding the diversity and spatiotemporal role of the inflammatory response and its interactions with resident airway cells is critical to advancing knowledge on asthma pathogenesis and the development of new therapeutic approaches. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Leadership Pipeline på rejse i den offentlige sektor

DEFF Research Database (Denmark)

Nielsen, Jeppe; Dahl, Kristian Aagaard

2015-01-01

Forestillingen om, at ledelsesopgaven varierer alt efter hvilket lederniveau, der fokuseres på, trækker spor tilbage til en række tidlige ledelsesteoretikere. I de senere år har tilgangen på ny tiltrukket sig opmærksomhed såvel i praksisfeltet som blandt forskere, nok tydeligst illustreret via ud...... hinanden, og at der i praksis ikke var én, men flere idéer om Leadership Pipeline, der rejste på tværs af felter og organisationer....... udbredelse af Leadership Pipeline modellen. Forskningslitteraturen om Leadership Pipeline er imidlertid beskeden. Med teoretisk ammunition fra ”idé på rejse” perspektivet og et multi-level case studie i den danske offentlige sektor belyser artiklen udbredelse og implementering af Leadership Pipeline. Ved...... at anvende skiftende teoretiske begreber og henholdsvis zoome-ind (organisationsniveau) og zoome-ud (feltniveau) viser artiklen, hvordan en række gensidigt forbundne teoretiserings- og translationsaktiviteter sikrede Leadership Pipeline legitimitet og fremskyndede dens udbredelse samtidig med, at forskellige...

Injury Biomechanics of C2 Dens Fractures

OpenAIRE

Yoganandan, Narayan; Pintar, Frank; Baisden, Jamie; Gennarelli, Thomas; Maiman, Dennis

2004-01-01

The objective of this study is to analyze the biomechanics of dens fractures of the second cervical vertebra in the adult population due to motor vehicle crashes. Case-by-case records from the Crash Injury Research and Engineering Network (CIREN) and National Automotive Sampling System (NASS) databases were used. Variables such as change in velocity, impact direction and body habitus were extracted. Results indicated that similarities exist in the two databases despite differences in sampling...

Zoologien i den klassiske islamiske kultur

OpenAIRE

Provencal, Philippe; Aarab, Ahmed

2014-01-01

Denne artikel bringer en oversigt over forskning i den zoologiske videnskab, således som denne er kommet til udtryk i tekster skrevet på klassisk arabisk fra anden halvdel af 700-tallet til 1400-tallet. I lyset af nyere forskning og med eksempler hentet fra de arabiske tekster selv, bliver en ny bedømmelse af disse teksters faglige indhold foreslået. This article brings a survey of research on the science of zoology in the Classical Arabic/Islamic Culture as revealed in texts on this subje...

Kampen om den røde ko - dominerende temaer i dansk kvægavl i 1800-tallets slutning

DEFF Research Database (Denmark)

Gjerløff, Anne Katrine

2009-01-01

En analyse af kvægavlslitteratur fra 1800-tallets anden halvdel viser spændingerne mellem avlernes ønske om profit og hensynene til racerenhed og national og regional identitet. Ideen om den perfekte ko var omdiskuteret og modsætningerne mellem koens udseende og dens ydelse er tydelige i periodens...... bedømmelser af "den gode ko". Artiklen komkluserer at et fokus på opfattelser og brug af dyr kan give nye vinkler på traditionelle historiske emnefelter. Udgivelsesdato: april...

Characterization of RyDEN (C19orf66 as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication.

Directory of Open Access Journals (Sweden)

Youichi Suzuki

2016-01-01

Full Text Available Dengue virus (DENV is one of the most important arthropod-borne pathogens that cause life-threatening diseases in humans. However, no vaccine or specific antiviral is available for dengue. As seen in other RNA viruses, the innate immune system plays a key role in controlling DENV infection and disease outcome. Although the interferon (IFN response, which is central to host protective immunity, has been reported to limit DENV replication, the molecular details of how DENV infection is modulated by IFN treatment are elusive. In this study, by employing a gain-of-function screen using a type I IFN-treated cell-derived cDNA library, we identified a previously uncharacterized gene, C19orf66, as an IFN-stimulated gene (ISG that inhibits DENV replication, which we named Repressor of yield of DENV (RyDEN. Overexpression and gene knockdown experiments revealed that expression of RyDEN confers resistance to all serotypes of DENV in human cells. RyDEN expression also limited the replication of hepatitis C virus, Kunjin virus, Chikungunya virus, herpes simplex virus type 1, and human adenovirus. Importantly, RyDEN was considered to be a crucial effector molecule in the IFN-mediated anti-DENV response. When affinity purification-mass spectrometry analysis was performed, RyDEN was revealed to form a complex with cellular mRNA-binding proteins, poly(A-binding protein cytoplasmic 1 (PABPC1, and La motif-related protein 1 (LARP1. Interestingly, PABPC1 and LARP1 were found to be positive modulators of DENV replication. Since RyDEN influenced intracellular events on DENV replication and, suppression of protein synthesis from DENV-based reporter construct RNA was also observed in RyDEN-expressing cells, our data suggest that RyDEN is likely to interfere with the translation of DENV via interaction with viral RNA and cellular mRNA-binding proteins, resulting in the inhibition of virus replication in infected cells.

Metoder til den børnefaglige undersøgelse

DEFF Research Database (Denmark)

Sørensen, Kresta Munkholt

Denne afhandling omhandler rammerne for sagsbehandlingen i forhold til udsatte børn, unge og deres familier. Afhandlingen er centreret omkring, hvordan socialarbejderne oplever metoderne til den børnefaglige undersøgelse, og er udarbejdet i et komparativt perspektiv med fokus på følgende tre...

HIV-surveys bij hoog-risicogroepen in Den Haag 2005

NARCIS (Netherlands)

Veen MG van; Wagemans MAJ; Burg I van den; Tonino-van der Marel E; Leeuwen AP van; Laar MJW van de; CIE

2006-01-01

Verspreiding van HIV en SOA kan mogelijk optreden doordat hoog-risicogroepen een brug vormen naar de rest van de bevolking in Nederland. Dit blijkt uit de HIV-survey die is uitgevoerd in Den Haag onder prostituees werkzaam in de raamprostitutie, clubs en op de tippelzone en onder migranten

Den danske FN-aktivismes storhed og fald 1945-2016

DEFF Research Database (Denmark)

Jakobsen, Peter Viggo; Kjærsgaard, Kristine

2017-01-01

Traktat Organisation (NATO) og amerikansk-ledede koalitioner. De store skift i den danske FN aktivisme i perioden 1945-2016 analyseres i tre domæner: diplomati, økonomi og militær ved hjælp af fire indikatorer: frivillighed, initiativrigdom, risikovillighed og ressourceforbrug. FN’s aktivismens storhed og...

Polypoidal Choroidal Vasculopathy: Definition, Pathogenesis, Diagnosis, and Management.

Science.gov (United States)

Cheung, Chui Ming Gemmy; Lai, Timothy Y Y; Ruamviboonsuk, Paisan; Chen, Shih-Jen; Chen, Youxin; Freund, K Bailey; Gomi, Fomi; Koh, Adrian H; Lee, Won-Ki; Wong, Tien Yin

2018-05-01

Polypoidal choroidal vasculopathy (PCV) is an age-related macular degeneration (AMD) subtype and is seen particularly in Asians. Previous studies have suggested disparity in response to intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents between PCV and typical AMD, and thus, the preferred treatment for PCV has remained unclear. Recent research has provided novel insights into the pathogenesis of PCV, and imaging studies based on OCT suggest that PCV belongs to a spectrum of conditions characterized by pachychoroid, in which disturbance in the choroidal circulation seems to be central to its pathogenesis. Advances in imaging, including enhanced depth imaging, swept-source OCT, en face OCT, and OCT angiography, have facilitated the diagnosis of PCV. Importantly, 2 large, multicenter randomized clinical trials evaluating the safety and efficacy of anti-VEGF monotherapy and combination with photodynamic therapy (PDT) recently reported initial first-year outcomes, providing level I evidence to guide clinicians in choosing the most appropriate therapy for PCV. In this review, we summarize the latest updates in the epidemiologic features, pathogenesis, and advances in imaging and treatment trials, with a focus on the most recent key clinical trials. Finally, we propose current management guidelines and recommendations to help clinicians manage patients with PCV. Remaining gaps in current understanding of PCV, such as significance of polyp closure, high recurrence rate, and heterogeneity within PCV, are highlighted where further research is needed. Copyright © 2018 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

Polycystic Kidney Disease: Pathogenesis and Potential Therapies

Science.gov (United States)

Takiar, Vinita; Caplan, Michael J.

2011-01-01

Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent, inherited condition for which there is currently no effective specific clinical therapy. The disease is characterized by the progressive development of fluid-filled cysts derived from renal tubular epithelial cells which gradually compress the parenchyma and compromise renal function. Current interests in the field focus on understanding and exploiting signaling mechanisms underlying disease pathogenesis as well as delineating the role of the primary cilium in cystogenesis. This review highlights the pathogenetic pathways underlying renal cyst formation as well as novel therapeutic targets for the treatment of PKD. PMID:21146605

Molecular pathogenesis and mechanisms of thyroid cancer

Science.gov (United States)

Xing, Mingzhao

2013-01-01

Thyroid cancer is a common endocrine malignancy. There has been exciting progress in understanding its molecular pathogenesis in recent years, as best exemplified by the elucidation of the fundamental role of several major signalling pathways and related molecular derangements. Central to these mechanisms are the genetic and epigenetic alterations in these pathways, such as mutation, gene copy-number gain and aberrant gene methylation. Many of these molecular alterations represent novel diagnostic and prognostic molecular markers and therapeutic targets for thyroid cancer, which provide unprecedented opportunities for further research and clinical development of novel treatment strategies for this cancer. PMID:23429735

Der Effekt von Hohlraumströmung auf den Druckausgleich

NARCIS (Netherlands)

Bentum, van C.A.; Suma, A.B.; Kalkman, I.M.; Koster, T.; Geurts, C.P.W.; Ruscheweyh, xx

2011-01-01

KURZFASSUNG. Hinterlüftete Fassaden sind ein häufig verwendetes System der Verkleidung. Auf der Vorderseite eines Hohlraums wird eine durchlässige äußere Schichtangebracht. Über den Raum selbst wird ein Druckausgleich zwischen der Außenseite und der Innenseite des Hohlraums erzielt. Dieser Effekt

Zum Vorkommen von Kalkglimmern (Margarit, Cintonit) in den Schweizer Alpen

NARCIS (Netherlands)

Niggli, E.

1955-01-01

In einem ersten Abschnitt stellt der Verfasser die ihm bekannten Literaturstellen zusammen. Im zweiten Abschnitt werden eigene Untersuchungen beschrieben, die als vorläufiges Resultat ergaben, dass Clintonit in den Schweizer Alpen bislang nicht einwandfrei nachgewiesen ist, dass aber Margarit ein

The pathogenesis of HIV infection: stupid may not be so dumb after all

Directory of Open Access Journals (Sweden)

Smith Stephen M

2006-09-01

Full Text Available Abstract In the mid-1990's, researchers hypothesized, based on new viral load data, that HIV-1 causes CD4+ T-cell depletion by direct cytopathic effect. New data from non-human primate studies has raised doubts about this model of HIV-1 pathogenesis. Despite having high levels of viremia, most SIV infections are well tolerated by their natural hosts. Two recent studies of these models provide information, which may be useful in determining how HIV-1 causes CD4+ T-cell loss. A full understanding of pathogenesis may lead to novel therapies, which preserve the immune system without blocking virus replication.

UTIs in small animal patients: part 1: etiology and pathogenesis.

Science.gov (United States)

Smee, Nicole; Loyd, Kimberly; Grauer, Greg

2013-01-01

Understanding how urinary tract infections (UTIs) can occur and how to classify them can help the practitioner to make a plan for treatment. This review summarizes the etiology, pathogenesis, and host defense mechanisms associated with bacterial UTIs in dogs and cats. UTIs in Small Animal Patients: Part 2: Diagnosis, Treatment, and Complications will appear in the March/April 2013 issue of the Journal of the American Animal Hospital Association.

Thiamine potentiates chemoprotective effects of ibuprofen in DEN induced hepatic cancer via alteration of oxidative stress and inflammatory mechanism.

Science.gov (United States)

Afzal, Muhammad; Kazmi, Imran; Khan, Ruqaiyah; Rana, Poonam; Kumar, Vikas; Al-Abbasi, Fahad A; Zamzami, Mazin A; Anwar, Firoz

2017-06-01

Present study, was an effort to scrutinize the molecular and biochemical role of ibuprofen and thiamine combination in diethylnitrosamine (DEN)-induced HCC in Wistar rats. Single intraperitoneal injection of DEN (200 mg/kg) was used for induction of HCC in rats. The rats were divided into eight various groups. DEN induced rats were treated with pure ibuprofen (40 mg/kg) and thiamine in combination for the period of 12th weeks. The protocol was terminated after the 16th week. Exposure of DEN up-regulated the levels of different serum biochemical parameters, antioxidant enzyme level, Alfa-fetoprotein (AFP) and reduced the level of High density lipoprotein (HDL) in Wistar rats along with the alteration in pro-inflammatory cytokines viz., interlukin-6 (IL-6), Tumor necrosis factor (TNF-α) and Interleukin-1β (IL-1β) with decrease in body weight. Macroscopic evaluation, revealed DEN group rats confirmed the expansion of hepatic nodules, which were reduced by the individual treatment of ibuprofen and thiamine, but the synergistic treatment of ibuprofen and thiamine confirm the significant reduction of hepatic nodules. Further, this combination possesses the significant chemoprotective effect in DEN-induced HCC by restoring the hepatic enzymes and other biomarkers along with an alteration in pro-inflammatory cytokines. The above result concludes that ibuprofen and thiamine combination possess potent anti-cancerous activity. Copyright © 2017 Elsevier Inc. All rights reserved.

Epstein-Barr Virus-Encoded RNAs: Key Molecules in Viral Pathogenesis

Energy Technology Data Exchange (ETDEWEB)

Iwakiri, Dai [Institute for Genetic Medicine, Hokkaido University, N15 W7 Kita-Ku, Sapporo 060-0815 (Japan)

2014-08-06

The Epstein-Barr virus (EBV) is known as an oncogenic herpesvirus that has been implicated in the pathogenesis of various malignancies. EBV-encoded RNAs (EBERs) are non-coding RNAs expressed abundantly in latently EBV-infected cells. Herein, I summarize the current understanding of the functions of EBERs, including the interactions with cellular factors through which EBERs contribute to EBV-mediated pathogenesis. Previous studies have demonstrated that EBERs are responsible for malignant phenotypes in lymphoid cells, and can induce several cytokines that can promote the growth of various EBV-infected cancer cells. EBERs were also found to bind retinoic acid-inducible gene I (RIG-I) and thus activate its downstream signaling. Furthermore, EBERs induce interleukin-10, an autocrine growth factor for Burkitt’s lymphoma cells, by activating RIG-I/interferon regulatory factor 3 pathway, suggesting that EBER-mediated innate immune signaling modulation contributes to EBV-mediated oncogenesis. Recently, EBV-infected cells were reported to secret EBERs, which were then recognized by toll-like receptor 3 (TLR3), leading to the induction of type I interferon and inflammatory cytokines, and subsequent immune activation. Furthermore, EBER1 was detected in the sera of patients with active EBV-infectious diseases, suggesting that EBER1-meidated TLR3 signaling activation could account for the pathogenesis of active EBV-infectious diseases.

Epstein-Barr Virus-Encoded RNAs: Key Molecules in Viral Pathogenesis

International Nuclear Information System (INIS)

Iwakiri, Dai

2014-01-01

The Epstein-Barr virus (EBV) is known as an oncogenic herpesvirus that has been implicated in the pathogenesis of various malignancies. EBV-encoded RNAs (EBERs) are non-coding RNAs expressed abundantly in latently EBV-infected cells. Herein, I summarize the current understanding of the functions of EBERs, including the interactions with cellular factors through which EBERs contribute to EBV-mediated pathogenesis. Previous studies have demonstrated that EBERs are responsible for malignant phenotypes in lymphoid cells, and can induce several cytokines that can promote the growth of various EBV-infected cancer cells. EBERs were also found to bind retinoic acid-inducible gene I (RIG-I) and thus activate its downstream signaling. Furthermore, EBERs induce interleukin-10, an autocrine growth factor for Burkitt’s lymphoma cells, by activating RIG-I/interferon regulatory factor 3 pathway, suggesting that EBER-mediated innate immune signaling modulation contributes to EBV-mediated oncogenesis. Recently, EBV-infected cells were reported to secret EBERs, which were then recognized by toll-like receptor 3 (TLR3), leading to the induction of type I interferon and inflammatory cytokines, and subsequent immune activation. Furthermore, EBER1 was detected in the sera of patients with active EBV-infectious diseases, suggesting that EBER1-meidated TLR3 signaling activation could account for the pathogenesis of active EBV-infectious diseases

Epigenetics: The missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes

OpenAIRE

Gilbert, Elizabeth R.; Liu, Dongmin

2012-01-01

Type 2 diabetes (T2D) is a growing health problem worldwide. While peripheral insulin resistance is common during obesity and aging in both animals and people, progression to T2D is largely due to insulin secretory dysfunction and significant apoptosis of functional β-cells, leading to an inability to compensate for insulin resistance. It is recognized that environmental factors and nutrition play an important role in the pathogenesis of diabetes. However, our knowledge surrounding molecular ...

Physician deficit in USA - where is the bottleneck? [Ärztemangel in den USA - wo wird es eng?

Directory of Open Access Journals (Sweden)

Walid, M. Sami

2009-05-01

Full Text Available [english] The population of physician professionals in the US has been carefully controlled over the last century to ensure profitable work for people in the profession and provide physician workforce for the nation. However, the emergence of managed care in the US has spurred speculations that the US will experience a substantial excess of physicians by the beginning of the 21st century. In light of these forecasts, the number of residency positions funded by Medicare has been restricted. Additionally, enrollment at allopathic medical schools has been decreasing over the last two decades of the Twentieth Century. It is now evident that those predictions were erroneous and that the current supply of physicians does not exceed the demand for their services. That is why the Association of American Medical Colleges now aims to increase the number of US medical school graduates by 3,000 yearly by the year 2015. However, even if this difficult mission can be accomplished, the US can still have a deficit of 200,000 physicians by the year 2020. The reason is the bottleneck that controls the flow of medical graduates aiming to enter residency programs and get clinical training in order to obtain the license required to practice medicine. With the restriction on the number of Medicare-funded residency positions in the US an increase in US medical school graduates will only displace an equal number of international medical graduates applying for residency positions and consequently reduce the number of international medical graduates who join the physician workforce. This will probably not increase the number of practicing physicians. Shortage of physicians will remain an issue and undeniably make access to medical care problematic for all citizens. [german] Im 20. Jahrhundert wurde die Zahl der Ärzte in den Vereinigten Staaten sorgfältig reguliert, um lohnende Arbeitsbedingungen im ärztlichen Beruf und die Versorgung mit Ärzten für die Bev

Transnational organisatorisk innovation i den offentlige sektor

DEFF Research Database (Denmark)

Hansen, Morten Balle

Artiklen undersøger tre problemstillinger: 1) Hvor udbredt er forskellige former for transnational organisatorisk innovation i den danske offentlige sektor? 2) Hvordan er disse organisatoriske innovationer relateret til hinanden? 3) Er forskelle i deres udbredelse signifikant relateret til...... innovation og dels på forskelle og ligheder mellem statslige og kommunale organisationer. Elleve former for organisatorisk innovation, hvoraf mange ofte forbindes med New Public Management (NPM), er inkluderet i de empiriske analyser: Privatisering/udlicitering, Bestiller-Udfører model, Kontraktstyring, Mål...

Mikrokredittens globale fortælling og dens etiske problemstillinger

DEFF Research Database (Denmark)

Jensen, Thessa

2011-01-01

, men har netop fået en ny drejning med anklager om korruption mod en af mikrokredittens fædre, Mohammad Yunus1. Denne artikel prøver at fokusere på de etiske problemstillinger, som er mikrokreditten iboende. Etiske problemer, som ikke umid- delbart synes særlig belyst i den foreliggende litteratur om...

Når logopæden hører stemmer

DEFF Research Database (Denmark)

Iwarsson, Jenny

2011-01-01

Da jeg for leden henvendte mig til et bilværksted på Amager og gav en kort beskrivelse af den foruroligende lyd jeg registreret i min bil, svarede bilmekanikeren hurtigt, at det med stor sandsynlighed var tale om et kuglelager i venstre forhjul der skulle skiftes. Efter en kort prøvetur hvor meka...

The Gut Microbiome and HIV-1 Pathogenesis: A Two Way Street

Science.gov (United States)

Dillon, Stephanie M.; Frank, Daniel N.; Wilson, Cara C.

2016-01-01

HIV-1 infection is associated with substantial damage to the gastrointestinal (GI) tract resulting in structural impairment of the epithelial barrier and a disruption of intestinal homeostasis. The accompanying translocation of microbial products and potentially microbes themselves from the lumen into systemic circulation has been linked to immune activation, inflammation, and HIV-1 disease progression. The importance of microbial translocation in the setting of HIV-1 infection has led to a recent focus on understanding how the communities of microbes that make up the intestinal microbiome are altered during HIV-1 infection and how they interact with mucosal immune cells to contribute to inflammation. This review details the dysbiotic intestinal communities associated with HIV-1 infection and their potential link to HIV-1 pathogenesis. We detail studies that begin to address the mechanisms driving microbiota-associated immune activation and inflammation and the various treatment strategies aimed at correcting dysbiosis and improving the overall health of HIV-1 infected individuals. Finally, we discuss how this relatively new field of research can advance to provide a more comprehensive understanding of the contribution of the gut microbiome to HIV-1 pathogenesis. PMID:27755100

Bioinformatics Analysis Reveals Genes Involved in the Pathogenesis of Ameloblastoma and Keratocystic Odontogenic Tumor.

Science.gov (United States)

Santos, Eliane Macedo Sobrinho; Santos, Hércules Otacílio; Dos Santos Dias, Ivoneth; Santos, Sérgio Henrique; Batista de Paula, Alfredo Maurício; Feltenberger, John David; Sena Guimarães, André Luiz; Farias, Lucyana Conceição

2016-01-01

Pathogenesis of odontogenic tumors is not well known. It is important to identify genetic deregulations and molecular alterations. This study aimed to investigate, through bioinformatic analysis, the possible genes involved in the pathogenesis of ameloblastoma (AM) and keratocystic odontogenic tumor (KCOT). Genes involved in the pathogenesis of AM and KCOT were identified in GeneCards. Gene list was expanded, and the gene interactions network was mapped using the STRING software. "Weighted number of links" (WNL) was calculated to identify "leader genes" (highest WNL). Genes were ranked by K-means method and Kruskal-Wallis test was used (Preview data was used to corroborate the bioinformatics data. CDK1 was identified as leader gene for AM. In KCOT group, results show PCNA and TP53 . Both tumors exhibit a power law behavior. Our topological analysis suggested leader genes possibly important in the pathogenesis of AM and KCOT, by clustering coefficient calculated for both odontogenic tumors (0.028 for AM, zero for KCOT). The results obtained in the scatter diagram suggest an important relationship of these genes with the molecular processes involved in AM and KCOT. Ontological analysis for both AM and KCOT demonstrated different mechanisms. Bioinformatics analyzes were confirmed through literature review. These results may suggest the involvement of promising genes for a better understanding of the pathogenesis of AM and KCOT.

Surgical Orthodontic Treatment of an Impacted Canine in the Presence of Dens Invaginatus and Follicular Cyst

Science.gov (United States)

Canevello, Carola; Laffi, Nicola

2014-01-01

Introduction. “Dens invaginatus” is a dental anomaly which originates from the invagination of the ameloblastic epithelium into the lingual surface of the dental crown during the odontogenesis. It can cause early pulpal necrosis, abscesses, retention or dislocation of contiguous elements, cysts, and internal resorptions. It normally affects the upper lateral incisors. In the following study the authors will discuss the etiology, the physiopathology, and the surgical-orthodontic management of a rare case of impacted canine associated with dens invaginatus and follicular cyst, with the aim of highlighting the importance of taking any therapeutic decision based on the data available in the literature. Case Report. The present study describes a combined surgical-orthodontic treatment of an impacted canine associated with a lateral incisor (2.2) suffering from type III dens invaginatus with radicular cyst, in a 15-year-old patient. Discussion. When treating a dens invaginatus there are different therapeutic solutions: they depend on the gravity of the anomaly and on the association with the retention of a permanent tooth. The aesthetic and functional restoration becomes extremely important when performing a surgical-orthodontic repositioning. PMID:24963421

[Ulrike Plath. Esten und Deutsche in den baltischen Provinzen Russlands] / Olaf Mertelsmann

Index Scriptorium Estoniae

Mertelsmann, Olaf, 1969-

2013-01-01

Arvustus: Plath, Ulrike. Esten und Deutsche in den baltischen Provinzen Russlands: Freundheitskonstruktionen, lebenswelten, Kolonialphantasien 1750-1810 (Veröffenlichungen des Nordost-Instituts, Bd. 11.)Harrasowitz. Wiesbaden 2011

Oncology. Pt. 1. General part, epidemiology - pathogenesis - basic principles of therapy. 2. upd. ed.; Die Onkologie. T. 1. Allgemeiner Teil, Epidemiologie - Pathogenese - Grundprinzipien der Therapie

Energy Technology Data Exchange (ETDEWEB)

Hiddemann, Wolfgang [Muenchen Univ. Klinikum Grosshadern (Germany). Medizinische Klinik und Poliklinik III; Bartram Claus R. (eds.) [Heidelberg Univ. (Germany). Inst. fuer Humangenetik

2010-07-01

The book Oncology is aimed to communicate the compiled knowledge on tumor development and cancer: fundamental knowledge base, practice related know-how for diagnostics and therapy. Part 1 includes the following chapters: epidemiology and pathogenesis, basic principles of diagnostics, basic principles of therapy, complication of malign growth, tumors in the gastrointestinal tract, female genital carcinomas, kidney and urinary tract carcinomas, respiratory tract and lung carcinomas, carcinomas in the head - neck area, bone and soft tissue carcinomas, pediatric tumors, hematological neoplasm, other carcinomas. The book can be used as reference for clinical work. [German] Die gesamte Onkologie - verlaessliches Wissen fuer Ihre Kompetenz. ''Die Onkologie'' stellt sich der Herausforderung, das staendig wachsende Wissen ueber Tumorerkrankungen in seiner Gesamtheit zu vermitteln. Sowohl inhaltlich als auch didaktisch auf hoechsten Niveau: Fundiertes Grundlagenwissen zum umfassenden Nachschlagen Praxisrelevantes Know-how fuer Diagnostik und Therapie Systematischer Aufbau fuer das Verstaendnis der komplexen Zusammenhaenge Die Onkologie - eine Enzyklopaedie der modernen klinischen Tumorlehre. Angesehene Experten aus Klinik, Forschung und Praxis liefern Ihnen in Teil1 klinisches Grundlagenwissen zu den Grundprinzipien der Therapie, Epidemiologie, Aetiologie und Pathogenese, sowie zu Komplikationen des malignen Wachstums. Zum Nachschlagen und Anwenden: finden Sie alle Optionen - auch fuer Ihren schwierigsten Fall. Der uebersichtliche Aufbau und die exzellenten Abbildungen erleichtern Ihnen das schnelle Auffinden und Verstaendnis der gesuchten Informationen. Fuer den Alltag onkologisch taetiger Aerzte ist Die Onkologie ein unentbehrlicher Meilenstein. (orig.)

Physiology and pathogenesis of gastroesophageal reflux disease.

Science.gov (United States)

Mikami, Dean J; Murayama, Kenric M

2015-06-01

Gastroesophageal reflux disease (GERD) is one of the most common problems treated by primary care physicians. Almost 20% of the population in the United States experiences occasional regurgitation, heartburn, or retrosternal pain because of GERD. Reflux disease is complex, and the physiology and pathogenesis are still incompletely understood. However, abnormalities of any one or a combination of the three physiologic processes, namely, esophageal motility, lower esophageal sphincter function, and gastric motility or emptying, can lead to GERD. There are many diagnostic and therapeutic approaches to GERD today, but more studies are needed to better understand this complex disease process. Copyright © 2015 Elsevier Inc. All rights reserved.

Dijk- en oeverval aan den cal. Willem Annapolder (Gem. Kapelle)

NARCIS (Netherlands)

Verhagen, H.J.

1936-01-01

Foto's van de aanleg van de dijk- en oeverval aan den cal. Willem Annapolder (Gem. Kapelle) 3. Linkerhelft dijkval Willem Annapolder. 30 Dec. 1936 4. Rechtehelft dijkval Willem Annapolder. 30 Dec. 1936 5. Overzicht dijkval Willem Annaolder. 30 Dec. 1936 6. Kleikisting binnendijks aangebacht. 14/15

EU er på vej mod at udvikle og implementere europæiske regnskabsstandarder indenfor den offentlige sektor

DEFF Research Database (Denmark)

Pontoppidan, Caroline Aggestam

2015-01-01

I maj 2013 var Europa-Kommisionen og Eurostat vært for en konference med formålet at forhandle om den fremtidige udvikling af harmoniserede offentlige regnskabsstandarder ('European Public Sector Accounting Standards' EPSAS) som skal anvendes af alle medlemslande i den Europæiske Union...

Molecular approaches to the analysis of deformed wing virus replication and pathogenesis in the honey bee, Apis mellifera

Directory of Open Access Journals (Sweden)

Pettis Jeffery S

2009-12-01

Full Text Available Abstract Background For years, the understanding of the pathogenetic mechanisms that underlie honey bee viral diseases has been severely hindered because of the lack of a cell culture system for virus propagation. As a result, it is very imperative to develop new methods that would permit the in vitro pathogenesis study of honey bee viruses. The identification of virus replication is an important step towards the understanding of the pathogenesis process of viruses in their respective hosts. In the present study, we developed a strand-specific RT-PCR-based method for analysis of Deformed Wing Virus (DWV replication in honey bees and in honey bee parasitic mites, Varroa Destructor. Results The results shows that the method developed in our study allows reliable identification of the virus replication and solves the problem of falsely-primed cDNA amplifications that commonly exists in the current system. Using TaqMan real-time quantitative RT-PCR incorporated with biotinylated primers and magnetic beads purification step, we characterized the replication and tissue tropism of DWV infection in honey bees. We provide evidence for DWV replication in the tissues of wings, head, thorax, legs, hemolymph, and gut of honey bees and also in Varroa mites. Conclusion The strategy reported in the present study forms a model system for studying bee virus replication, pathogenesis and immunity. This study should be a significant contribution to the goal of achieving a better understanding of virus pathogenesis in honey bees and to the design of appropriate control measures for bee populations at risk to virus infections.

Demokratisk forum eller fallit: Valgkamp i den lokale avis set gennem en lingvistisk lup

OpenAIRE

Frederiksen, Line

2007-01-01

Denne specialeafhandling undersøger indholdet af DAGBLADET Roskildes artikler om den kom-munale valgkamp i 1997, 2001 og 2005 i de tre dage før, under og efter valget. Formålet med un-dersøgelsen er at dokumentere, hvilke overordnede temaer, der ligger i teksterne og efterfølgende ridse de demokratiske konsekvenser af tematiseringen op i forhold til læserne af DAGBLADET. I dansk kontekst udgør undersøgelsesperioden, hvad Pippa Norris definerer som ’den postmo-derne fase’ i politisk kommunikat...

Den öffentlichen Raum „hacken“ und die Menschen beeinflussen

Directory of Open Access Journals (Sweden)

Irwan Ahmett

2014-05-01

Full Text Available 65 Jahre nach der Unabhängigkeitserklärung Indonesiens kletterte ein Mann mittleren Alters in Jakarta verbotenerweise auf das Dach des indonesischen Parlamentsgebäudes. Seine Botschaft waren drei Wörter, die sehr gut die Stimmung im Land zum Ausdruck brachten. Seine „Waffe“ war eine Farbspraydose für zwei US-Dollar. Pong Harjatmos Aktion stieß auf öffentliche Resonanz, weil klar war, dass es nicht mehr ausreicht, sich von der Politik abzuwenden und diesem ruhmreichen Gebäude lediglich den Mittelfinger zu zeigen. Die zahllosen Korruptionsaffären sind nur die Spitze eines Eisbergs. Harjatmo, ein einfacher Mann, überbrachte den Volks vertreter_innen eine Botschaft, die aus der Tiefe seines Gewissens kam: „Honest, Fair, Firm“. (... Waffen und Kämpfe sind untrennbar. Ich war immer überzeugt davon, dass die Effizienz einer Waffe vor allem davon abhängt, wie sie eingesetzt wird und nicht von der Kraft der sie nutzenden Person.

Store daginstitutioner og deres betydning for den pædagogiske dagligdag

DEFF Research Database (Denmark)

Gammelby, Marie Louise; Brandi-Hansen, Sissel

2014-01-01

Forfatterne søger at afdække, hvilken betydning nye store daginstitutioner har for de mulighedsbetingelser, der opstilles for dels den pædagogiske praksis og, som en konsekvens heraf, dels for børns udfoldelsesmuligheder....

Biological roles of cysteine proteinases in the pathogenesis of Trichomonas vaginalis

Science.gov (United States)

Hernández, Hilda M.; Marcet, Ricardo; Sarracent, Jorge

2014-01-01

Human trichomonosis, infection with Trichomonas vaginalis, is the most common non-viral sexually transmitted disease in the world. The host-parasite interaction and pathophysiological processes of trichomonosis remain incompletely understood. This review focuses on the advancements reached in the area of the pathogenesis of T. vaginalis, especially in the role of the cysteine proteinases. It highlights various approaches made in this field and lists a group of trichomonad cysteine proteinases involved in diverse processes such as invasion of the mucous layer, cytoadherence, cytotoxicity, cytoskeleton disruption of red blood cells, hemolysis, and evasion of the host immune response. A better understanding of the biological roles of cysteine proteinases in the pathogenesis of this parasite could be used in the identification of new chemotherapeutic targets. An additional advantage could be the development of a vaccine in order to reduce transmission of T. vaginalis. PMID:25348828

Crossing Boundaries in Qualitative Research – Entwurf einer empirischen Reflexivität der qualitativen Sozialforschung in Deutschland und den USA

Directory of Open Access Journals (Sweden)

Stephanie Bethmann

2015-04-01

Full Text Available Der vorliegende Beitrag widmet sich der Analyse von Prozessen der Wissenskonstruktion in der qualitativen Sozialforschung im transatlantischen Vergleich. Basierend auf explorativen Forschungsergebnissen stellen wir mit den Idealtypen engaging und observing zwei Forschungsstile vor, die sich in den Praktiken der Konstruktion von Nähe und Distanz zum Gegenstand deutlich unterscheiden. Beides, Nähe und Distanz, wird dabei nicht als innere Haltung von Forschenden oder als rigoros nationaler Stil verstanden, sondern als Produkte konkreter Arbeitspraktiken, die in Zusammenhang mit nationalen Forschungskonventionen, Rahmenbedingungen und Epistemologien stehen. Gemeinsam ist beiden Interaktionsmustern die zentrale Fundierung im amerikanischen Pragmatismus, wobei die These einer auffallend unterschiedlichen Bezugnahme auf den amerikanischen Pragmatismus in den beiden Länderkontexten diskutiert wird: Stehen in Deutschland vorwiegend dessen erkenntnistheoretische Prämissen im Mittelpunkt, sieht sich die gegenwärtige US-amerikanische Methodenlandschaft eher dessen gesellschaftspolitischen Traditionen verpflichtet. Ausgehend von diesen Beobachtungen wird abschließend die Forderung formuliert, Reflexivität in der qualitativen Sozialforschung stärker auf den Boden empirischer Analysen zu stellen. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1502191

Den danske samfundsudvikling 1848-2012 og marxistisk, neoklassisk, keynesiansk, monetaristisk og nykeynesiansk teori

DEFF Research Database (Denmark)

Madsen, Poul Thøis

Efter i adskillige år at have undervist ud fra andres bøger og efter mange tilløb besluttede forfatteren sig for at skrive sin egen forskningsbaserede bog til Det Samfundsvidenskabelige Fællessemester, som dækker fem lektioner om den politiske økonomis historie og den danske økonomiske udvikling........ Ambitionen har været at udarbejde en kort appetitvækker, der gør, at studerende får et overblik og forstår nogle basale sammenhænge og får lyst til at vide mere om økonomisk teori, dansk og international økonomi og ikke mindst debatterne herom....

Von den Liven von Oesel / August Ludwig Schlözer

Index Scriptorium Estoniae

Schlözer, August Ludwig

2008-01-01

Avaldatud Eberhard Winkleri initsiatiivil A. L. Schlözeri teose põhjal: Gesammelte Nachrichten von den Ueberresten der Liven, in Livland und Kurland. (1770), mis moodustab osa teosest: Schlözer, August Ludwig. M. Johann Joseph Haigold's Beylagen zum Neuveränderten Russland. Zweiter Theil. Riga und Leipzig, 1770

An Interview with DOROTHY E. DENNING, Oral History 424

OpenAIRE

Yost, Jeffrey R.

2013-01-01

Computer Security History Project Computer security pioneer Dorothy Denning discusses her career including her Lattice Model for Computer Security, research on database security, intrusion detection, and other areas, such as her influential textbooks. The interview also addresses computer security research infrastructure and collaborators at various institutions where she worked including Purdue University, SRI International, Digital Equipment Corporation, Georgetown University, and Naval ...

Restoration of u.v.-induced excision repair in Xeroderma D cells transfected with the denV gene of bacteriophage T4

International Nuclear Information System (INIS)

Arrand, J.E.; Squires, S.; Bone, N.M.; Johnson, R.T.

1987-01-01

The heritable DNA repair defect in human Xeroderma D cells, resulting in failure to incise at u.v. light-induced pyrimidine dimers, has been partially but stably corrected by transfection of immortalised cells with the denV pyrimidine dimer glycosylase gene of bacteriophage T4. Transfectants selected either for a dominant marker on the mammalian vector carrying the prokaryotic gene or for dominant marker plus resistance to killing by u.v. light, were shown to express the denV gene to varying degrees. denV expression results in significant phenotypic change in the initially repair-deficient, u.v.-hypersensitive cells. Increased resistance to u.v. light and more rapid recovery of replicative DNA synthesis following u.v. irradiation were correlated with improved repair DNA synthesis and with a novel dimer incision capability present in denV transfected Xeroderma cells but not as evident in transfected normal cells. Most transfectants contain a single integrated copy of the denV gene; increase in denV copy number does not result in either increased gene expression or enhanced survival to u.v. light. Results show that expression of a heterologous prokaryotic repair gene can partially compensate for the genetic defect in a human Xeroderma D cell. (author)

Den iscenesatte folkelighed

Directory of Open Access Journals (Sweden)

Néstor Garcia Canclini

1994-09-01

Full Text Available Hvad er "det folkelige" og hvad er "folkekultur"? Néstor Garcia Canclini har i denne artikel sat sig for at dekonstruere begrebet "det folkelige" og beskrive den måde, forskellige grupper bruger og misbruger begrebet på. Han analyserer tre fremherskende idéer om folkelighed: folkloristernes romantiske idé om det oprindelige, der blev ødelagt af massekulturen, massemediernes popularitetsbegreb og endelig populisternes - både de højre- og venstreorienteredes - iscenesættelse af folkeligheden. Desuden ser han på to marxistiske skolers opfattelse af forholdet mellem de dominerende og undertrykte klasser og forskellige definitioner af folkelig- hed. Ligesom Anamaria Fadul argumenterer Canclini for nødvendigheden af en ny, tværdiciplinær forskning, som opfanger kompleksitet og flerty- digheder i forholdet mellem de undertrykte og dominerende og ser "det folkelige" som en tragisk komedie med modsætninger og flertydighed snarere end en evigt fremadskrivende episk fortælling. Artiklen er en forkortet udgave af kapitel 5 i Canclinis bog fra 1989: "Culturas Hibridas - Estrategias para entrat y salir de la modernidad. Mexico: Grijalbo.

Nuclear chemistry and Radiochemistry in the USA; Kern- und Radiochemie in den USA

Energy Technology Data Exchange (ETDEWEB)

Kronenberg, A. [Los Alamos National Lab., NM (United States). Isotope and Nuclear Chemistry Div.; Stoyer, M. [Lawrence Livermore National Lab., CA (United States)

2004-04-01

Nuclear chemistry and radiochemistry are very young sciences which developed at an extremely brisk pace within a very short period of time after the discovery of nuclear fission in 1938, and caused profound societal changes. In the United States, nuclear chemistry developed very differently from Germany, where nuclear research initially had been banned after the Second World War. The prime mover in the development in the United States was the Manhattan Project, the construction of the atomic bomb. The counteract the impending shortage of qualified personnel, important institutions have begun to establish training and support programs in the field. The National Laboratories in the United States introduced a National Security Internship Program, while the U.S. Department of Energy (DOE) tries to promote cooperation, and thus the training of personnel, by launching programs of its own. Yet, a greater shortage of qualified personnel is becoming apparent. The situation of nuclear chemistry and radiochemistry in the United States can be summarized in the finding that research at the National Laboratories is very wide ranging. It receives sufficient funds from the DOE. However, the National Laboratories show a very high proportion of elderly personnel, a problem which will have to be corrected in the years to come. This may be helped by the Summer Schools financed by the DOE, though a summer school of six weeks cannot replace a sound training in nuclear chemistry of the kind still to be found in Germany. (orig.) [German] Kern- und Radiochemie sind sehr junge Wissenschaften, die sich nach der Entdeckung der Kernspaltung 1938 innerhalb kuerzester Zeit extrem rasant entwickelt und tiefe gesellschaftliche Veraenderungen bewirkt haben. In den USA hat sich die Kernchemie sehr unterschiedlich im Vergleich zu Deutschland entwickelt, wo die Kernforschung nach dem 2. Weltkrieg vorerst verboten war. Massgeblich in den USA war dabei das Manhatten-Projekt zum Bau von Nuklearwaffen

[Memel als Brücke zu den baltischen Ländern] / Ralph Tuchtenhagen

Index Scriptorium Estoniae

Tuchtenhagen, Ralph, 1961-

2014-01-01

Arvustus: Memel als Brücke zu den baltischen Ländern. Kulturgeschichte Klaipedas vom Mittelalter bis ins 20. Jahrhundert. (Tagungsberichte der Historischen Kommission für ost- und westpreussische Landesforschung. Bd. 26)

Pathogenesis of motor neuron disease

Institute of Scientific and Technical Information of China (English)

Xuefei Wang

2006-01-01

OBJECTIVE: To summarize and analyze the factors and theories related to the attack of motor neuron disease, and comprehensively investigate the pathogenesis of motor neuron disease.DATA SOURCES: A search of Pubmed database was undertaken to identify articles about motor neuron disease published in English from January 1994 to June 2006 by using the keywords of "neurodegenerative diseases". Other literatures were collected by retrieving specific journals and articles.STUDY SELECTION: The data were checked primarily, articles related to the pathogenesis of motor neuron disease were involved, and those obviously irrelated to the articles were excluded.DATA EXTRACTION: Totally 54 articles were collected, 30 of them were involved, and the other 24 were excluded.DATA SYNTHESIS: The pathogenesis of motor neuron disease has multiple factors, and the present related theories included free radical oxidation, excitotoxicity, genetic and immune factors, lack of neurotrophic factor,injury of neurofilament, etc. The studies mainly come from transgenic animal models, cell culture in vitro and patients with familial motor neuron disease, but there are still many restrictions and disadvantages.CONCLUSION: It is necessary to try to find whether there is internal association among different mechanisms,comprehensively investigate the pathogenesis of motor neuron diseases, in order to provide reliable evidence for the clinical treatment.

Helicobacter pylori infection: An overview of bacterial virulence factors and pathogenesis

Directory of Open Access Journals (Sweden)

Cheng-Yen Kao

2016-02-01

Full Text Available Helicobacter pylori pathogenesis and disease outcomes are mediated by a complex interplay between bacterial virulence factors, host, and environmental factors. After H. pylori enters the host stomach, four steps are critical for bacteria to establish successful colonization, persistent infection, and disease pathogenesis: (1 Survival in the acidic stomach; (2 movement toward epithelium cells by flagella-mediated motility; (3 attachment to host cells by adhesins/receptors interaction; (4 causing tissue damage by toxin release. Over the past 20 years, the understanding of H. pylori pathogenesis has been improved by studies focusing on the host and bacterial factors through epidemiology researches and molecular mechanism investigations. These include studies identifying the roles of novel virulence factors and their association with different disease outcomes, especially the bacterial adhesins, cag pathogenicity island, and vacuolating cytotoxin. Recently, the development of large-scale screening methods, including proteomic, and transcriptomic tools, has been used to determine the complex gene regulatory networks in H. pylori. In addition, a more available complete genomic database of H. pylori strains isolated from patients with different gastrointestinal diseases worldwide is helpful to characterize this bacterium. This review highlights the key findings of H. pylori virulence factors reported over the past 20 years.

Franchising i den svenska fastighetsmäklarbranschen : Franchising in the Swedish real estate industry

OpenAIRE

Narkander, Christoffer; Ilchishina, Elena

2010-01-01

Sammanfattning Bakgrund Idag blir det allt mer vanligt att mindre enskilda mäklarbyråer ansluter sig till de stora franchisekedjorna. Anslutningen innebär att den tidigare enskilde aktören lämnar sitt varumärke och sin tidigare affärsidé för att istället ta del av ett välkänt varumärke och ett framgångsrikt affärskoncept. Syfte & metod Syftet med uppsatsen är att studera vilka positiva och negativa effekter franchising bidrar med i den svenska fastighetsmäklarbranschen samt vilka ekonom...

Lärares yrkesetiska dilemman och den ökande juridifieringen i Sverige

Directory of Open Access Journals (Sweden)

Gunnel Colnerud

2014-11-01

Full Text Available Följande artikel under temat “Etikbølgen i yrkesutdanning og praksis” beskriver och diskuterar etik och juridik i läraryrket med utgångspunkt i det dilemma som lärare själva anser vara ett av de svåraste enligt två svenska empiriska studier – att ingripa mot en kollega som handlar etiskt klandervärt mot elever. Artikeln diskuterar vidare den dygdetiska kritik mot regeletik som förekom vid tillkomsten av de etiska principerna. Vidare pekar den på de problem som följer av att lärarna är föremål för en tilltagande juridifiering. En våg, en bølge, kan beröra endast ytan som en krusning eller vara en djupgående och energirik rörelse. För att använda den aktuella metaforen på mitt studieobjekt skulle jag vilja påstå att diskussionen av lärares yrkesetik och medvetenheten om svenska lärares etiska riktlinjer utvecklades till en våg av endast blygsam storlek. I dagsläget (2014 har den ersatts av en juridisk våg med stor kraft.Nyckelord: etik i läraryrket, etiska dilemman, juridifiering av lärarpraktikenEnglish summary: Teachers’ ethical dilemmas and the juridification of the Swedish schoolIn this article, ethics and law in the teaching profession are described and discussed, starting with the ethical dilemma that teachers point to as the most difficult, according to referred empirical studies – intervention when a colleague acts in an ethically incorrect way towards students. Furthermore the author discusses the critique coming from virtue ethics in relation to ethical principles and shows that even Aristotle suggests ethical principles under certain circumstances. Swedish teachers’ ethical principles had very little time to be achieved before an increasing juridification of teaching took place. This phenomenon is discussed in terms of professional autonomy and professional judgement.http://dx.doi.org/10.5324/eip.v8i2.1856

Advances in understanding the pathogenesis of HLH.

Science.gov (United States)

Usmani, G Naheed; Woda, Bruce A; Newburger, Peter E

2013-06-01

Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory disorder resulting from immune dysfunction reflecting either primary immune deficiency or acquired failure of normal immune homeostasis. Familial HLH includes autosomal recessive and X-linked disorders characterized by uncontrolled activation of T cells and macrophages and overproduction of inflammatory cytokines, secondary to defects in genes encoding proteins involved in granule-dependent cytolytic pathways. In older children and adults, HLH is associated more often with infections, malignancies, autoimmune diseases, and acquired immune deficiencies. HLH, macrophage activation syndrome, sepsis, and systemic inflammatory response syndrome are different clinical entities that probably represent a common immunopathological state, termed cytokine storm. These conditions may be clinically indistinguishable; all include massive inflammatory response, elevated serum cytokine levels, multi-organ involvement, haemophagocytic macrophages, and often death. Tissues of haematopoietic and lymphoid function are directly involved; other organs are secondarily damaged by circulating cytokines and chemokines. Haemophagocytic disorders are now increasingly diagnosed in the context of severe inflammatory reactions to viruses, malignancies and systemic connective tissue diseases. Many of these cases may reflect underlying genetic predispositions to HLH. The detection of gene defects has contributed considerably to our understanding of HLH, but the mechanisms leading to acquired HLH have yet to be fully determined. © 2013 John Wiley & Sons Ltd.

Den universelle velfærdsstat er under pres

DEFF Research Database (Denmark)

Villadsen, Kaspar

2016-01-01

Hvordan kan man hjælpe uden at ødelægge selv-ansvaret? Hvilke krav skal der være for at få hjælp? Og hvad er skadevirkningerne af en generøs og let opnåelig hjælp? Mange af de spørgsmål, der præger dagens debat, gjorde sig også gældende, da den universelle velfærdsstat dukkede op i starten af 1900...

Endline report – Liberia, DEN-L MFS II country evaluations

NARCIS (Netherlands)

Gotomo, S.; Peters, B.; Kusters, C.S.L.; Peabody, S.; Washington Gopeya, M.

2015-01-01

This report presents the findings of the endline of the evaluation of the organisational capacity component of the MFS II country evaluations. The focus of this report is Liberia, DEN-L. The format is based on the requirements by the synthesis team and NWO/WOTRO. The endline was carried out in 2014.

The Advantages of Hybrid 4DEnVar in the Context of the Forecast Sensitivity to Initial Conditions

Science.gov (United States)

Song, Hyo-Jong; Shin, Seoleun; Ha, Ji-Hyun; Lim, Sujeong

2017-11-01

Hybrid four-dimensional ensemble variational data assimilation (hybrid 4DEnVar) is a prospective successor to three-dimensional variational data assimilation (3DVar) in operational weather prediction centers currently developing a new weather prediction model and those that do not operate adjoint models. In experiments using real observations, hybrid 4DEnVar improved Northern Hemisphere (NH; 20°N-90°N) 500 hPa geopotential height forecasts up to 5 days in a NH summer month compared to 3DVar, with statistical significance. This result is verified against ERA-Interim through a Monte Carlo test. By a regression analysis, the sensitivity of 5 day forecast is associated with the quality of the initial condition. The increased analysis skill for midtropospheric midlatitude temperature and subtropical moisture has the most apparent effect on forecast skill in the NH including a typhoon prediction case. Through attributing the analysis improvements by hybrid 4DEnVar separately to the ensemble background error covariance (BEC), its four-dimensional (4-D) extension, and climatological BEC, it is revealed that the ensemble BEC contributes to the subtropical moisture analysis, whereas the 4-D extension does to the midtropospheric midlatitude temperature. This result implies that hourly wind-mass correlation in 6 h analysis window is required to extract the potential of hybrid 4DEnVar for the midlatitude temperature analysis to the maximum. However, the temporal ensemble correlation, in hourly time scale, between moisture and another variable is invalid so that it could not work for improving the hybrid 4DEnVar analysis.

New Insights into the Pathogenesis of MDS and the rational therapeutic opportunities.

Science.gov (United States)

Abou Zahr, Abdallah; Bernabe Ramirez, Carolina; Wozney, Jocelyn; Prebet, Thomas; Zeidan, Amer M

2016-01-01

Myelodysplastic syndromes (MDS) include a heterogeneous group of acquired hematopoietic malignancies characterized by ineffective hematopoiesis, peripheral cytopenias, and a varying propensity for progression to acute myeloid leukemia. The clinical heterogeneity in MDS is a reflection of its molecular heterogeneity. Better understanding of aberrant epigenetics, dysregulation of immune responses, and del(5q) MDS has provided the rationale for well-established treatments in MDS. Further understanding of abnormal signal transduction and aberrant apoptosis pathways has led to development of new rational therapies that are in advanced phases of clinical translation. This review seeks to describe recent developments in our understanding of the pathogenesis of MDS and the potential therapeutic implications of these observations.

Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii: a review

Directory of Open Access Journals (Sweden)

William J Sullivan Jr

2009-03-01

Full Text Available Parasite differentiation from proliferating tachyzoites into latent bradyzoites is central to pathogenesis and transmission of the intracellular protozoan pathogen Toxoplasma gondii. The presence of bradyzoite-containing cysts in human hosts and their subsequent rupture can cause life-threatening recrudescence of acute infection in the immunocompromised and cyst formation in other animals contributes to zoonotic transmission and widespread dissemination of the parasite. In this review, we discuss the evidence showing how the clinically relevant process of bradyzoite differentiation is regulated at both transcriptional and post-transcriptional levels. Specific regulatory factors implicated in modulating bradyzoite differentiation include promoter-based cis-elements, epigenetic modifications and protein translation control through eukaryotic initiation factor -2 (eIF2. In addition to a summary of the current state of knowledge in these areas we discuss the pharmacological ramifications and pose some questions for future research.

Activity rhythms and distribution of natal dens for red foxes

Science.gov (United States)

Wenyang, Zhou; Wanhong, Wei; Biggins, Dean E.

1995-01-01

The red fox, Vulpes vulpes, was investigated with snow tracking, radiotracking and directive observation at the Haibei Research Station of Alpine Meadow Ecosystem, Academia Sinica, from March to September 1994. The objectives of this study were to determine the distribution and use of natal dens, activity rhythms, and home range sizes for the foxes.

Calibration of radioprotection equipment gamma radiation at the Laboratory of Ionizing Radiation Metrology - DEN/UFPE

International Nuclear Information System (INIS)

Nazario, Macilene; Khoury, Helen; Hazin, Clovis

2003-01-01

This work presents aspects of the radioprotection equipment calibration service of the Laboratory for Metrology of Ionizing Radiations (LMRI) of the DEN/UFPE related to the calibration procedures, characteristics of the radiation beam and the evaluation of equipment calibrated in the period of 2001-2002. The LMRI-DEN/UFPE is one of the four laboratories in Brazil licensed by the Brazilian Nuclear Energy Commission for the execution of calibration services on area, surface contamination and personal monitors used by industries, hospitals, universities and research institutes using radioactive sources

Pathogenesis of Hepatic Encephalopathy

Directory of Open Access Journals (Sweden)

Irena Ciećko-Michalska

2012-01-01

Full Text Available Hepatic encephalopathy can be a serious complication of acute liver failure and chronic liver diseases, predominantly liver cirrhosis. Hyperammonemia plays the most important role in the pathogenesis of hepatic encephalopathy. The brain-blood barrier disturbances, changes in neurotransmission, neuroinflammation, oxidative stress, GABA-ergic or benzodiazepine pathway abnormalities, manganese neurotoxicity, brain energetic disturbances, and brain blood flow abnormalities are considered to be involved in the development of hepatic encephalopathy. The influence of small intestine bacterial overgrowth (SIBO on the induction of minimal hepatic encephalopathy is recently emphasized. The aim of this paper is to present the current views on the pathogenesis of hepatic encephalopathy.

Pathogenesis of Hepatic Encephalopathy

Science.gov (United States)

Ciećko-Michalska, Irena; Szczepanek, Małgorzata; Słowik, Agnieszka; Mach, Tomasz

2012-01-01

Hepatic encephalopathy can be a serious complication of acute liver failure and chronic liver diseases, predominantly liver cirrhosis. Hyperammonemia plays the most important role in the pathogenesis of hepatic encephalopathy. The brain-blood barrier disturbances, changes in neurotransmission, neuroinflammation, oxidative stress, GABA-ergic or benzodiazepine pathway abnormalities, manganese neurotoxicity, brain energetic disturbances, and brain blood flow abnormalities are considered to be involved in the development of hepatic encephalopathy. The influence of small intestine bacterial overgrowth (SIBO) on the induction of minimal hepatic encephalopathy is recently emphasized. The aim of this paper is to present the current views on the pathogenesis of hepatic encephalopathy. PMID:23316223

Rommet som den tredje pedagog - En studie av pedagogers forståelse av rommets betydning - med fokus på estetisk virksomhet

OpenAIRE

Krokstad, Inger Elisabeth

2014-01-01

Masteroppgaven «Rommet som den tredje pedagog i tre Reggio Emilia-inspirerte barnehager. En studie av pedagogers forståelse av rommets betydning –med fokus på estetisk virksomhet» har til hensikt å bidra til økt kunnskap om estetisk virksomhet som er forbundet med Reggio Emilias tanke om rommet som den tredje pedagog. Avhandlingens problemstilling er: Hvilke mønster kan identifiseres i barnehagepedagogens forståelse av rommet som den tredje pedagog-med fokus på estetisk virksomhet? ...

Fusion og koncentration i den danske svineslagterisektor

DEFF Research Database (Denmark)

Hansen, Henning Otte

2015-01-01

Strukturudviklingen i den danske slagterisektor er gået hurtig i de seneste ti-år. Koncentrationen steg kraftigt efter midten af 1980‘erne, men i de sidste 10-15 år er udviklingen i et vist omfang stagneret eller endog vendt, og koncentrationen har været faldende. En evt. fusion mellem Danish Crown...... og Tican vil sandsynligvis ikke opveje dette fald i koncentration. De historiske erfaringer fra sektoren viser endvidere, at virksomheder efter en fusion ofte taber markedsandele. Markedet for svinekød er blevet langt mere internationaliseret i de senere år, og dette alene vil øge konkurrencen....

Kvantitative metoder og den globale fattigdomsmålsætning

DEFF Research Database (Denmark)

Casse, Thorkil

2007-01-01

Artiklen problematiserer den model (kun økonomisk vækst), som internationale organisationer anvender, når det skal forklares, hvordan fattigdomme halveres. Måske ved relativ få, trods ofte anvendelse, hvad begrebet fattigdomsorienteret vækst indbefatter. Artiklen fokuserer primært på PRSP (Povert...... Reduction Strategy Papers) i Burkina Faso og Madagascar....

Dansk international landevejstransport - en branche og dens forening i konstant udvikling

DEFF Research Database (Denmark)

Klatt, Martin

Festskrift til interesseorganisationen International Transport Danmarks 60-års jubilæum. Bogen fortæller, hvordan foreningen FDE/ITD og dens medlemmer siden 1980'erne har tilpasset sig de ændrede vilkår på transportmarkederne. Bogen redegør for liberaliseringen af EU's transportmarked...

Kvinden, diakonissen og sygeplejersken i Den danske Diakonissestiftelses etableringsfase 1863-1873

DEFF Research Database (Denmark)

Lauritzen, Jette

and nurse in the establishing phase of `Den danske Diakonissestiftelse`, from 1863 to 1873, was partially culturally unacceptable and not culturally recognisable for the bourgeoisie. This meant that the deaconesses had to fight on all fronts to gain recognition and the possibility to further the cause...

Kvinden, diakonissen og sygeplejersken i Den danske Diakonissestiftelses etableringsfase 1863-1873

DEFF Research Database (Denmark)

Lauritzen, Jette

2005-01-01

and nurse in the establishing phase of `Den danske Diakonissestiftelse`, from 1863 to 1873, was partially culturally unacceptable and not culturally recognisable for the bourgeoisie. This meant that the deaconesses had to fight on all fronts to gain recognition and the possibility to further the cause...

Ligene i kælderen og den kollektive amnesi. W.G. Sebald og debatten om bombardementerne af de tyske byer under Anden Verdenskrig

DEFF Research Database (Denmark)

Hoffmann, Birthe

2008-01-01

den såkaldte 'moral bombing' af Tyskland og sætter den debat, der fulgte på Sebalds tese om den (litterære) fortrængning af disse erfaringer ind i en større kontekst. Gennem en række litterære eksempler diskuteres Sebalds æstetiske kriterier for en adekvat repræsentation af erfaringer, der i en vis...

Untersuchung perturbativer und nichtperturbativer Struktur der Momente hadronischer Ereignisformvariablen mit den Experimenten JADE und OPAL

CERN Document Server

Pahl, Christoph Johannes

2007-01-01

In Hadronproduktionsdaten der e+e− - Vernichtungsexperimente JADE und OPAL messen wir die ersten f¨unf Momente von zw¨olf hadronischen Ereignisformvariablen bei Schwerpunktsenergien von 14 bis 207GeV. Aus dem Vergleich der QCD NLO-Vorhersage mit den mittels MC-Modellen um Hadronisierung korrigierten Daten erhalten wir den Referenzwert der starken Kopplung αs(MZ0) = 0.1254 ± 0.0007(stat.) ± 0.0010(exp.)+0.0009 −0.0023(had.)+0.0069 −0.0053(theo.) . F¨ur einige, insbesondere h¨ohere, Momente sind systematische Unzul¨anglichkeiten in der QCD NLO-Vorhersage erkenntlich. Simultane Fits an zwei Momente unter Annahme identischer Renormierungsskalen ergeben Skalenwerte von xμ=0.057 bis xμ=0.196 . Wir pr¨ufen Vorhersagen verschiedener nichtperturbativer Modelle. Aus der Single Dressed Gluon - N¨aherung ergibt sich eine perturbative Vorhersage in O(α5 s ) mit zu vernachl¨assigender Energiepotenzkorrektur, die den Mittelwert von Thrust auf Hadronniveau gut beschreibt mit αs(MZ0) = 0.1186 ± 0.0007(st...

Psychometric properties of DAPonDEN: definitions, attitudes and practices in relation to diarrhea during enteral nutrition questionnaire.

Science.gov (United States)

Majid, Hazreen A; Bin Sidek, Muhamad Adam; Chinna, Karuthan

2013-01-01

To investigate the psychometric properties of the developed 21 item questionnaire to measure definitions, attitudes and management practices in relation to diarrhea during enteral nutrition (DAPonDEN). Data were analyzed using exploratory factor analysis from a cross sectional study of 102 nurses aged 18 and over, conducted from December 2011 to February 2012 in Malaysia. Face and content validity of DAPonDEN were first evaluated by few expert panels and patients. For this study, adult nurses were recruited from the adult wards. In the final model, three items in DAPonDEN were dropped. In the exploratory factor analysis, five factors were extracted that explained a total of 55% of the variation in the remaining 18 items. The Kaiser-Meyer-Olkin (KMO) value was 0.723. For definition, there were two underlying factors: 'Key items in defining diarrhea' and 'non-key items in defining diarrhea'. For attitude there was a single factor. For practice, there were two underlying factors: 'enteral nutrition (EN) related' and 'awareness related'. The items in each of the underlying dimensions seem to measure the respective concepts for definition, attitude and practices adequately. The 18-items DAPonDEN instrument can be a suitable education tool to be used in relation to diarrhea during EN. Copyright © 2013 Elsevier Inc. All rights reserved.

Rückwärtsintegration - Zu den Verhältnissen Gymnasium, Hochschule und Arbeitswelt

Science.gov (United States)

Schmid, Gerhard; Heppner, Winfried; Focht, Eva

In seiner 2007 erschienen Sammlung von Vorträgen und Essays beschäftigt sich Wolfgang Frühwald, mit der Frage "Wieviel Wissen brauchen wir?“ [1] Die Kernproblematik moderner Wissenschaft und Forschung sieht der Autor, emeritierter Ordinarius für Neuere Deutsche Literaturwissenschaft und von 1992 bis 1997 Präsident der Deutschen Forschungsgemeinschaft, einerseits in der zunehmenden Spezialisierung der Wissenschaftsbereiche, andererseits in der Gefahr der Abkoppelung der Naturwissenschaften von den Geisteswissenschaften. Wiederholt plädiert er dafür, über der rasanten Entwicklung beispielsweise in der Biologie und Physik, die historische, gesellschaftliche und besonders die ethische Dimension der Forschung nicht zu übersehen und fordert eine übergeordnete Theorie der Wissenschaft, die nur im Dialog zwischen den einzelnen Fachgebieten zu entwickeln sei.

The challenge of reforming the WTO dispute settlement understanding

OpenAIRE

Hauser, Heinz; Zimmermann, Thomas A.

2003-01-01

Die im Mai 2003 abgelaufene Frist für den Abschluss der Verhandlungen über Verbesserungen und Klarstellungen zum WTO-Übereinkommen über dei Streitschlichtung (Dispute Settlement Understanding; DSU) unter dem Doha-Mandat wurde verfehlt. Die WTO-Mitglieder einigten sich jedoch im Juli 2003 auf eine Verlängerung des Verhandlungsmandates bis Ende Mai 2004. Der vorliegende Beitrag fasst die Verhandlungen zur Überprüfung des Streitschlichtungsverfahrens ("DSU review") kurz zusammen. Die Hauptstreit...

CheckDen, a program to compute quantum molecular properties on spatial grids.

Science.gov (United States)

Pacios, Luis F; Fernandez, Alberto

2009-09-01

CheckDen, a program to compute quantum molecular properties on a variety of spatial grids is presented. The program reads as unique input wavefunction files written by standard quantum packages and calculates the electron density rho(r), promolecule and density difference function, gradient of rho(r), Laplacian of rho(r), information entropy, electrostatic potential, kinetic energy densities G(r) and K(r), electron localization function (ELF), and localized orbital locator (LOL) function. These properties can be calculated on a wide range of one-, two-, and three-dimensional grids that can be processed by widely used graphics programs to render high-resolution images. CheckDen offers also other options as extracting separate atom contributions to the property computed, converting grid output data into CUBE and OpenDX volumetric data formats, and perform arithmetic combinations with grid files in all the recognized formats.

Endodontic retreatment of dens invaginatus presenting with gutta-percha overfilling at the attached gingiva and chronic apical periodontitis: unusual clinical report.

Science.gov (United States)

Robazza, Carlos Roberto Colombo; Alves e Motta, Julio Cesar; de Carli, Marina Lara; de Oliveira Pedreira, Fernanda Rafaelly; Hanemann, Joao Adolfo Costa

2013-05-01

This work describes the retreatment of an unusual case of dens invaginatus with gutta-percha overfilling at the gingival mucosa and chronic apical periodontitis in a 34-year-old woman. Initial periapical radiograph showed the presence of type II dens invaginatus with poor quality obturation, root perforation and chronic apical periodontitis of tooth 22. Dens invaginatus is a tooth malformation caused by infolding of the dental papilla during tooth development. This anomaly has been associated with increased prevalence of pulpal and periapical diseases. Conventional endodontic retreatment was performed using rotary files and calcium hydroxide paste as intracanal dressing. After 7 days, root canal was filled with guttapercha points and Sealapex® sealer. Obturation was radiographically followed and, after 3 years, absence of fistula and periapical radiolucency was observed, thus conventional endodontic therapy proved to be successful. Conventional endodontic retreatment of type II dens invaginatus has been successful for a 3-year period, showing a better treatment alternative. Conservative endodontic retreatment of dens invaginatus should be considered to promote periapical healing with complete reconstitution of bone and periodontal ligament regeneration without signs of recurrence over a period of 3 years. Moreover, it preserves the entire tooth.

”Hvis du redder et menneske, så har du reddet hele verden”. Den gode moralen og den dialogiske samtalen i et norsk klasserom

Directory of Open Access Journals (Sweden)

Sylvi Penne

2009-03-01

Full Text Available Artikkelen tar utgangspunkt i observasjoner fra et klasserom på ungdomstrinnet der elevene arbeider tverrfaglig i norsk, KRL og samfunnsfag. Temaet er blant annet jødenes situasjon før og under krigen. Læreren er faglig dyktig, erfaren og sterkt engasjert i å formidle overgrepene som ble begått mot jødene, og elevene er velvillige. Likevel er elevenes konklusjon at de i en krigssituasjon med en etisk fordring, ikke ville ha våget å gjøre noe for å hjelpe jødene.      Med utgangspunkt i diskursteori, sosiokulturell teori og nyere kognitiv teori diskuteres disse svarene som ”naturlige” svar i den konteksten som skapes i klasserommet, og gjennom det språket som elevene utfordres i, deres ”mediational means”. Et konkret didaktisk problem er at den historiske fortellingen er borte og erstattet av empatisk innlevelse. Artikkelen avslutter med å hevde at uten en narrativ ramme forsvinner muligheten for etisk erkjennelse gjennom konteksten som skapes, og gjennom materialet som foreligger. Her ligger imidlertid nye didaktiske muligheter for engasjerte lærere, ikke minst gjennom litteraturundervisning.

Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-Cell Lymphoma and Its Therapeutic Implications

Directory of Open Access Journals (Sweden)

Georg Lenz

2015-05-01

Full Text Available Within the last couple of years, the understanding of the molecular mechanisms that drive the pathogenesis of diffuse large B-cell lymphoma (DLBCL has significantly improved. Large-scale gene expression profiling studies have led to the discovery of several molecularly defined subtypes that are characterized by specific oncogene addictions and significant differences in their outcome. Next generation sequencing efforts combined with RNA interference screens frequently identify crucial oncogenes that lead to constitutive activation of various signaling pathways that drive lymphomagenesis. This review summarizes our current understanding of the molecular pathogenesis of the activated B-cell-like (ABC DLBCL subtype that is characterized by poor prognosis. A special emphasis is put on findings that might impact therapeutic strategies of affected patients.

Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-Cell Lymphoma and Its Therapeutic Implications

Energy Technology Data Exchange (ETDEWEB)

Lenz, Georg [Translational Oncology, Department of Medicine A, Albert-Schweitzer Campus 1, University Hospital Münster, 48149 Münster (Germany); Cluster of Excellence EXC 1003, Cells in Motion, 48149 Münster (Germany)

2015-05-22

Within the last couple of years, the understanding of the molecular mechanisms that drive the pathogenesis of diffuse large B-cell lymphoma (DLBCL) has significantly improved. Large-scale gene expression profiling studies have led to the discovery of several molecularly defined subtypes that are characterized by specific oncogene addictions and significant differences in their outcome. Next generation sequencing efforts combined with RNA interference screens frequently identify crucial oncogenes that lead to constitutive activation of various signaling pathways that drive lymphomagenesis. This review summarizes our current understanding of the molecular pathogenesis of the activated B-cell-like (ABC) DLBCL subtype that is characterized by poor prognosis. A special emphasis is put on findings that might impact therapeutic strategies of affected patients.

Raccoon Use of Den Trees and Plant Associations in Western Mesophytic Forests: Tree Attributes and Availability or Landscape Heterogeneity?

Science.gov (United States)

Winston P. Smith; Keith M. Endres

2012-01-01

We monitored 15 radio-collared raccoons (Procyon lotor) on Davies Island in March 1987 - May 1988 to determine the extent to which individual tree attributes or spatial configuration of plant associations (habitat types) across the land-scape influenced den use. Of 1091 verified den sites, 428 were in tree cavities. Raccoon occurrence among 4 cover...

EU's tiltræden til EMRK - et sisyfosarbejde?

DEFF Research Database (Denmark)

Bang Fuglsang Madsen Sørensen, Henning

2015-01-01

EU-Domstolen afviste med opinion 2/13 den 18. december 2014 at lade EU tiltræde EMRK på grundlag af et udkast til en tiltrædelsesaftale. I artiklen behandles baggrunden for og det konkrete indhold i EU-Domstolens afvisning, hvorefter det undersøges, i hvilket omfang EMD fremover kan forventes...... at respektere EU-rettens forrang og dermed undlade at holde medlemsstaterne ansvarlige for påståede krænkelser som følge af medlemsstaternes forpligtelser efter EU-retten....

En obekväm sanning eller en stor bluff? : En analys av den visuella gestaltningen av fenomenet "global uppvärmning" i filmmediet

OpenAIRE

Eriksson, Anton; Oretoft, Mikael

2010-01-01

En uppsats som kritiskt granskar och analyserar den visuella gestaltningen i två dokumentärfilmer. Huvudtemat i filmerna är global uppvärmning och konsekvenserna av detta. Uppsatsens syfte är att undersöka den visuella gestaltningen av den miljödebatt som filmerna är en del i och genom detta belysa frågor som berör visuell kultur och popularisering av vetenskap.

MicroRNAs in the pathogenesis of cystic kidney disease.

Science.gov (United States)

Phua, Yu Leng; Ho, Jacqueline

2015-04-01

Cystic kidney diseases are common renal disorders characterized by the formation of fluid-filled epithelial cysts in the kidneys. The progressive growth and expansion of the renal cysts replace existing renal tissue within the renal parenchyma, leading to reduced renal function. While several genes have been identified in association with inherited causes of cystic kidney disease, the molecular mechanisms that regulate these genes in the context of post-transcriptional regulation are still poorly understood. There is increasing evidence that microRNA (miRNA) dysregulation is associated with the pathogenesis of cystic kidney disease. In this review, recent studies that implicate dysregulation of miRNA expression in cystogenesis will be discussed. The relationship of specific miRNAs, such as the miR-17∼92 cluster and cystic kidney disease, miR-92a and von Hippel-Lindau syndrome, and alterations in LIN28-LET7 expression in Wilms tumor will be explored. At present, there are no specific treatments available for patients with cystic kidney disease. Understanding and identifying specific miRNAs involved in the pathogenesis of these disorders may have the potential to lead to the development of novel therapies and biomarkers.

Review article: Pathogenesis and management of gastric carcinoid tumours.

Science.gov (United States)

Burkitt, M D; Pritchard, D M

2006-11-01

Gastric carcinoid tumours are rare, but are increasing in incidence. To discuss tumour pathogenesis and outline current approaches to patient management. Review of published articles following a Pubmed search. Although interest in gastric carcinoids has increased since it was recognized that they are associated with achlorhydria, to date there is no definite evidence that humans taking long-term acid suppressing medication are at increased risk. Type I tumours are associated with autoimmune atrophic gastritis and hypergastrinaemia, type II are associated with Zollinger-Ellison syndrome, multiple endocrine neoplasia-1 and hypergastrinaemia and sporadic type III carcinoids are gastrin-independent and carry the worst prognosis. Careful investigation of these patients is required, particularly to identify the tumour type, the source of hypergastrinaemia and the presence of metastases. Treatment can be directed at the source of hypergastrinaemia if type I or II tumours are still gastrin responsive and not growing autonomously. Type III tumours should be treated surgically. Advances in our understanding of the pathogenesis of gastric carcinoids have led to recent improvements in investigation and management. Challenges remain in identifying the genetic and environmental factors, in addition to hypergastrinaemia, that are responsible for tumour development in susceptible patients.

Scleroderma: nomenclature, etiology, pathogenesis, prognosis, and treatments: facts and controversies.

Science.gov (United States)

Fett, Nicole

2013-01-01

Scleroderma refers to a heterogeneous group of autoimmune fibrosing disorders. The nomenclature of scleroderma has changed dramatically in recent years, with morphea (localized scleroderma), limited cutaneous systemic sclerosis, diffuse cutaneous systemic sclerosis, and systemic sclerosis sine scleroderma encompassing the currently accepted disease subtypes. Major advances have been made in the molecular studies of morphea and systemic sclerosis; however, their etiologies and pathogenesis remain incompletely understood. Although morphea and systemic sclerosis demonstrate activation of similar inflammatory and fibrotic pathways, important differences in signaling pathways and gene signatures indicate they are likely biologically distinct processes. Morphea can cause significant morbidity but does not affect mortality, whereas systemic sclerosis has the highest disease-specific mortality of all autoimmune connective tissue diseases. Treatment recommendations for morphea and systemic sclerosis are based on limited data and largely expert opinions. Current collaborative efforts in morphea and systemic sclerosis research will hopefully lead to better understanding of the etiology and pathogenesis of these rare and varied diseases and improved treatment options. Published by Elsevier Inc.

Epigenetics in Medullary Thyroid Cancer: From Pathogenesis to Targeted Therapy.

Science.gov (United States)

Vitale, Giovanni; Dicitore, Alessandra; Messina, Erika; Sciammarella, Concetta; Faggiano, Antongiulio; Colao, Annamaria

2016-01-01

Medullary thyroid carcinoma (MTC) originates from the parafollicular C cells of the thyroid gland. Mutations of the RET proto-oncogene are implicated in the pathogenesis of MTC. Germline activating mutations of this gene have been reported in about 88-98% of familial MTCs, while somatic mutations of RET gene have been detected in about 23-70% of sporadic forms. Although these genetic events are well characterized, much less is known about the role of epigenetic abnormalities in MTC. The present review reports a detailed description of epigenetic abnormalities (DNA methylation, histone modifications and miRNA profile), probably involved in the pathogenesis and progression of MTC. A systematic review was performed using Pubmed and Google patents databases. We report the current understanding of epigenetic patterns in MTC and discuss the potential use of current knowledge in designing novel therapeutic strategies through epigenetic drugs, focusing on recent patents in this field. Taking into account the reversibility of epigenetic alterations and the recent development in this field, epigenetic therapy may emerge for clinical use in the near future for patients with advanced MTC.

Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses.

Science.gov (United States)

Martines, Roosecelis Brasil; Ng, Dianna L; Greer, Patricia W; Rollin, Pierre E; Zaki, Sherif R

2015-01-01

Ebola viruses and Marburg viruses include some of the most virulent and fatal pathogens known to humans. These viruses cause severe haemorrhagic fevers, with case fatality rates in the range 25-90%. The diagnosis of filovirus using formalin-fixed tissues from fatal cases poses a significant challenge. The most characteristic histopathological findings are seen in the liver; however, the findings overlap with many other viral and non-viral haemorrhagic diseases. The need to distinguish filovirus infections from other haemorrhagic fevers, particularly in areas with multiple endemic viral haemorrhagic agents, is of paramount importance. In this review we discuss the current state of knowledge of filovirus infections and their pathogenesis, including histopathological findings, epidemiology, modes of transmission and filovirus entry and spread within host organisms. The pathogenesis of filovirus infections is complex and involves activation of the mononuclear phagocytic system, with release of pro-inflammatory cytokines, chemokines and growth factors, endothelial dysfunction, alterations of the innate and adaptive immune systems, direct organ and endothelial damage from unrestricted viral replication late in infection, and coagulopathy. Although our understanding of the pathogenesis of filovirus infections has rapidly increased in the past few years, many questions remain unanswered. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

MicroRNA and Pathogenesis of Enterovirus Infection.

Science.gov (United States)

Ho, Bing-Ching; Yang, Pan-Chyr; Yu, Sung-Liang

2016-01-06

There are no currently available specific antiviral therapies for non-polio Enterovirus infections. Although several vaccines have entered clinical trials, the efficacy requires further evaluation, particularly for cross-strain protective activity. Curing patients with viral infections is a public health problem due to antigen alterations and drug resistance caused by the high genomic mutation rate. To conquer these limits in the development of anti-Enterovirus treatments, a comprehensive understanding of the interactions between Enterovirus and host cells is urgently needed. MicroRNA (miRNA) constitutes the biggest family of gene regulators in mammalian cells and regulates almost a half of all human genes. The roles of miRNAs in Enterovirus pathogenesis have recently begun to be noted. In this review, we shed light on recent advances in the understanding of Enterovirus infection-modulated miRNAs. The impacts of altered host miRNAs on cellular processes, including immune escape, apoptosis, signal transduction, shutdown of host protein synthesis and viral replication, are discussed. Finally, miRNA-based medication provides a promising strategy for the development of antiviral therapy.

Genes contributing to prion pathogenesis

DEFF Research Database (Denmark)

Tamgüney, Gültekin; Giles, Kurt; Glidden, David V

2008-01-01

incubation times, indicating that the conversion reaction may be influenced by other gene products. To identify genes that contribute to prion pathogenesis, we analysed incubation times of prions in mice in which the gene product was inactivated, knocked out or overexpressed. We tested 20 candidate genes...... show that many genes previously implicated in prion replication have no discernible effect on the pathogenesis of prion disease. While most genes tested did not significantly affect survival times, ablation of the amyloid beta (A4) precursor protein (App) or interleukin-1 receptor, type I (Il1r1...

HIV Pathogenesis: Abstracts from the March 2017 Cleveland Immunopathogenesis Consortium Meeting

Directory of Open Access Journals (Sweden)

Michael M. Lederman

2017-06-01

Full Text Available The Cleveland Immunopathogenesis Consortium (CLIC was launched in March 2004 by a small group of investigators (Ron Bosch, Jason Brenchley,  Steven Deeks, Danny Douek, Zvi Grossman, Robert Kalayjian, Clifford Harding, Michael Lederman, Leonid Margolis, Miguel Quinones, Benigno Rodriguez, Rafick Sekaly, Scott Sieg, and Guido Silvestri who were increasingly persuaded that immune activation was an important driver of HIV pathogenesis. We met around a chalk board and scribbled our models of pathogenesis, designed some experiments then went back home to do them. We met again soon to review our new and unpublished findings that refined and shaped these models. The data presentations were short, informal and heavy on discussion. The model worked well, the consortium was productive and the meetings catalyzed numerous collaborations and scores of high impact papers. The CLIC (less formally, the Bad Boys of Cleveland [1] has been meeting regularly since then. Consortium membership has expanded to include other investigators (some are listed in the presentations below. Whether the goal is to prevent the morbid complications of HIV infection, to understand the determinants of HIV persistence or the factors that protect from acquisition of infection, a more clear understanding of HIV immunopathogenesis is central. Here in this issue of Pathogens and Immunity is a brief summary of the most recent CLIC//BBC meeting held in Cleveland in March 2017.

Krig på kniven eller på kvaliteten - den danske TV-dokumentarisme i konkurrencealderen

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Helle Fritze

1992-08-01

Full Text Available I 90´ernes faktaformidling er TV-dokumentarismen et væsentligt omdrej- ningspunkt - da genren på både TV2 og DR med flagskibe som Fak2'eren, Reportageholdet, Søndagsdokumentaren, DR-Feature og DR-Dokumentar er genstand for en udpræget satsning, og desuden, direkte eller indirekte udtrykt, opfattes som eksempel til efterfølgelse for en faktaformidling på den halvkommercielle mediestrukturs betingelser. Således udgør genren med sin særlige institutionelle rolle et væsentligt spor til konkurrencealderens omdefinerede public service-begreb, og den kan derfor også være med til at pejle faktaformidlingens fremtidige udvikling.

Pathogenesis of ovarian cancer: current perspectives | Chesang ...

African Journals Online (AJOL)

Objective: To present a review of current knowledge of the pathogenesis of ovarian cancer and its clinical implications. Data Source: Extensive literature search was conducted to identify relevant studies. Study Selection: Studies in the English language about or related to pathogenesis of ovarian cancer were selected.

The role of EPCR in the pathogenesis of severe malaria

DEFF Research Database (Denmark)

Mosnier, Laurent O; Lavstsen, Thomas

2016-01-01

and therapeutic options, for which understanding of the mechanisms that cause death and disability in malaria is essential. The recent discoveries that certain variants of P. falciparum erythrocyte membrane protein 1 (PfEMP1) expressed on infected erythrocytes are intimately linked to the precipitation of severe...... the new paradigm that EPCR plays a central role in the pathogenesis of severe malaria. Thus, targeting of the PfEMP1-EPCR interaction and restoring the functionality of the PC system may provide new strategies for the development of novel adjuvant therapies for severe malaria....

Pathogenesis of the dry eye syndrome observed by optical coherence tomography in vitro

Science.gov (United States)

Kray, Oya; Lenz, Markus; Spöler, Felix; Kray, Stefan; Kurz, Heinrich

2011-06-01

Three dimensional optical coherence tomography (OCT) is introduced as a valuable tool to analyze the pathogenesis of corneal diseases. Here, OCT in combination with a novel in vitro model for the dry eye syndrome enables an improved understanding of the underlying damaging process of the ocular surface. En-face OCT projections indicate a deep structural damage of the epithelium and anterior stroma by osmotic forces.

Der chthonische Dionysos - Zur Wirkmacht des Mythos in den Mysterien

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Niklas Engel

2016-12-01

Full Text Available Dieser Beitrag soll aufzeigen, dass eine chthonische und eschatologische Dimension der dionysischen Göttlichkeit in verschiedenen Riten und Kulten des Gottes nachgewiesen werden kann und dabei keinesfalls mysterienexklusiv ist. Dazu soll der archäologische Befund, der Dionysos mit dem Jenseits und eschatologischen Ho nungen in Verbindung bringt, vorgestellt und untersucht werden. Darauf aufbauend soll belegt werden, dass diese jenseitige Dimension sich sowohl in Riten mit privatem Kern, hier am Beispiel der Oreibasia, als auch in Kultfeiern des ö entlichen Festkanons, wie den Anthesterien, zeigt. Abschließend soll dann Dionysos‘ Funktion in den eleusinischen Mysterien untersucht werden. This paper aims to show that a chthonic and eschatological dimension of dionysiac divinity can be found in various rites and cults of the god and that this is not exclusive for the mysteries. Recent archaeological evidence connecting Dionysos with the afterlife and eschatological expectations will be introduced and analyzed. is dimension manifests itself in rites with a private intent (e.g. the Oreibasia as well as public celebrations of the festival calendar (e.g. the Anthesteria. An analysis of Dionysos’ function in the eleusinian mysteries concludes the overview.

Aetio-pathogenesis of breast cancer | Abdulkareem | Nigerian ...

African Journals Online (AJOL)

This is a literature review on the aetiology and pathogenesis of breast cancer, which is the most common cancer worldwide, and the second leading cause of cancer death, especially in Western countries. Several aetiological factors have been implicated in its pathogenesis, and include age, genetics, family history, diet, ...

Viral pathogenesis in diagrams

National Research Council Canada - National Science Library

Tremblay, Michel; Berthiaume, Laurent; Ackermann, Hans-Wolfgang

2001-01-01

.... The 268 diagrams in Viral Pathogenesis in Diagrams were selected from over 800 diagrams of English and French virological literature, including one derived from a famous drawing by Leonardo da Vinci...

Over den invloed van insuline op de permeabiliteit der weefsels voor glucose

NARCIS (Netherlands)

Hamburger, Rudolf Jacobus

1930-01-01

In het voorafgaande overzicht van de literatuur, hebben wij gezien, dat vooral vele proeven in vivo, erop wijzen, dat bij diabetes, zoowel van den mensch als bij door pancreasextirpatie diabetisch gemaakte proefdieren minder glucose in de weefsels voorkomt en eveneens minder glucose daarin wordt

Mitochondrial Contribution to Parkinson's Disease Pathogenesis

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Anthony H. V. Schapira

2011-01-01

Full Text Available The identification of the etiologies and pathogenesis of Parkinson's disease (PD should play an important role in enabling the development of novel treatment strategies to prevent or slow the progression of the disease. The last few years have seen enormous progress in this respect. Abnormalities of mitochondrial function and increased free radical mediated damage were described in post mortem PD brain before the first gene mutations causing familial PD were published. Several genetic causes are now known to induce loss of dopaminergic cells and parkinsonism, and study of the mechanisms by which these mutations produce this effect has provided important insights into the pathogenesis of PD and confirmed mitochondrial dysfunction and oxidative stress pathways as central to PD pathogenesis. Abnormalities of protein metabolism including protein mis-folding and aggregation are also crucial to the pathology of PD. Genetic causes of PD have specifically highlighted the importance of mitochondrial dysfunction to PD: PINK1, parkin, DJ-1 and most recently alpha-synuclein proteins have been shown to localise to mitochondria and influence function. The turnover of mitochondria by autophagy (mitophagy has also become a focus of attention. This review summarises recent discoveries in the contribution of mitochondrial abnormalities to PD etiology and pathogenesis.

Et slag for den stolte håndværker

DEFF Research Database (Denmark)

Henriksen, Carsten

2013-01-01

Snart vil samfundet skrige af mangel på dygtige håndværkere, lyder det fra politikere og erhvervsfolk. Asterisk har sat den ansete amerikanske sociolog Richard Sennett i stævne for at få svar på, hvad vi kan lære af godt håndværk, og hvorfor det har trange kår i et konkurrencestyret vidensamfund....

Johannes van den Berg, Constrained by Jesus' Love. An Inquiry into ...

African Journals Online (AJOL)

Johannes van den Berg, Constrained by Jesus' Love. An Inquiry into the Motives of the missionary Awakening in Qreat Britain in the Period between 1698 and 1815, J. H. Kok, N.V., Kampen, 1956. P.S Dreyer. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT ...

Scintigraphic examinations after stent implantation in central airways; Szintigraphische Untersuchungen bei Stents in den zentralen Atemwegen

Energy Technology Data Exchange (ETDEWEB)

Richter, W.S.; Kettner, B.I.; Munz, D.L. [Klinik und Poliklinik fuer Nuklearmedizin, Universitaetsklinikum Charite, Medizinische Fakulteat der Humboldt-Univ. zu Berlin (Germany)

1998-03-01

Endotracheal and endobronchial stent implantation has been developed as an effective treatment of benign and malignant airway stenosis and of tracheo- or bronchoesophageal fistulas. The selection of the stent type depends on the kind and site of disease. Chest X-ray and bronchoscopy are the procedures of choice for monitoring of stent position, structure, and function. However, with scintigraphic methods the effects of stent implantation on pulmonary ventilation and perfusion can be assessed non-invasively. The validation of the effect of a stent implantation on mucociliary and tussive clearance remains to be elucidated. (orig.) [Deutsch] Die endotracheale und -bronchiale Stentimplantation wurde in den letzten Jahren als effektive Massnahme bei benignen und malignen Stenosen der Atemwege, drohendem Atemwegsverschluss und bei tracheo- bzw. bronchooesophagealen Fisteln eingefuehrt. Der gewaehlte Stenttyp richtet sich nach dem Implantationsort und den krankheitsbedingten Veraenderungen. Zum Monitoring von Lage, Struktur und Funktion eines Stents dienen Thoraxroentgenaufnahmen und die Bronchoskopie. Nuklearmedizinische Verfahren koennen nicht-invasiv den Effekt der Stenteinlage auf Lungenventilation und -perfusion belegen. Die Validierung des Effekts einer Stentimplantation auf die mukoziliaere und tussive Clearance steht noch aus. (orig.)

Pathogenesis of chronic pancreatitis: an evidence-based review of past theories and recent developments.

Science.gov (United States)

Stevens, Tyler; Conwell, Darwin L; Zuccaro, Gregory

2004-11-01

In the past several decades, four prominent theories of chronic pancreatitis pathogenesis have emerged: the toxic-metabolic theory, the oxidative stress hypothesis, the stone and duct obstruction theory, and the necrosis-fibrosis hypothesis. Although these traditional theories are formulated based on compelling scientific observations, substantial contradictory data also exist for each. Furthermore, the basic premises of some of these theories are directly contradictory. Because of the recent scientific progress in the underlying genetic, cellular, and molecular pathophysiology, there have been substantial advances in the understanding of chronic pancreatitis pathogenesis. This paper will provide an evidence-based review and critique of the traditional pathogenic theories, followed by a discussion of the new advances in pancreatic fibrogenesis. Moreover, we will discuss plausible pathogenic sequences applied to each of the known etiologies.

Pathogenesis Concept Of Extracranial Dissections In Iran

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Kavian Ghandehari

2017-02-01

Full Text Available Background: Dissection of Extracranial Internal Carotid Artery (EICA and Extracranial Vertebral Artery (EVA is an amportant cause of brain infarction with miscellaneous etiologies around the world. Methods: A prospective observational clinical study was conducted in Ghaem Hospital, Mashhad, Iran between 2008-2016. Diagnosis of brain infarction and TIA was made by stroke neurologist. Detection of EICA and EVA dissections were made by performing CT angiography  and MR angiography  or DSA in the suspected patients. Demographic features, clinical manifestations, territorial involvement, pathophysiology and pathogenesis of dissections were assessed in all of the patients. Pathogenesis of dissections was classified as Idiopathic, Trumatic, Postural and Genetic categories. Results: Twenty eight patients (21 males, 7 females were admitted with extracranial arterial dissection. Mean age of males and females with dissection was 39.81± 4.2 and 35.71±6.1 years respectively. Influence of gender on age of the patients was not significant, p>0.05. Among patients with extracranial dissection only 3.6% had atherosclerosis risk factors and 96.4% had no other cause for brain infarction. 100% of extracranial dissections in males occured in carotid territory, while 28.6% of females had dissection in the EVA. The influence of gender in territory of dissection was significant, p<0.05. Idiopathic dissections and genetic susceptibility was found in 10.7% and 3.6% of extracranial dissections respectively. 53.5% of the patienrs had trumatic pathogenesis for extracranial dissections and 32.1% developed dissection due to special neck  postures. Important details in pathophysiology and pathogenesis of extracranial dissections will be presented in the lecture. Conclusion: Stroke patients with extracranial dissections have characteristic demographic and  territorial involvement. Trumatic pathogenesis is the most frequent cause of dissection in Iran followed by neck

Distribución y abundancia anual de Ceratium dens (Peridinales: Ceratiaceae en el golfo de California, México

Directory of Open Access Journals (Sweden)

Roberto Cortés Altamirano

2000-06-01

Full Text Available La distribución de Ceratium dens en el Golfo de California se baso en tres campañas oceanográficas, su abundancia mensual (1995-96 en la Bahía de Mazatlán, y en tres fenómenos de mareas rojas presentadas en esta misma área. Se analizaron 52 muestras de fitoplancton recolectadas con red bongo con luz de malla de 64 µm y 120 muestras de agua con botella van Dorn en dos estaciones de recolecta y de tres eventos de marea roja en la Bahía de Mazatlán. Todas las muestras fueron contadas por el método del microscopio invertido. Los resultados indican que C. dens está presente en la región alta del Golfo de California y alrededor de Cabo San Lucas. En el ciclo 1995-96 la variación en la Bahía mostró dos períodos de máxima abundancia en primavera y otoño. Las abundancias presentaron una gran variación, en mar abierto fueron de 1-14 céls. l-1, en zonas costeras de 20-360 céls. l-1, y durante periodos de marea roja en 1985, 1989 y 1997 sus abundancias extremas fueron 144 000-256 000 céls. l-1, 100 000-400 000 céls. l-1 y 189 000-592 000 céls. l-1, respectivamente. Durante la marea roja, C. dens varía grandemente, a veces sustituida por Skeletonema costatum o Pseudonitzchia spp y Ceratium furca.. C. dens, aparenta tener una afinidad por los ambientes de alta productividad.Ceratium dens distribution in the Gulf of California was based on three oceanographic campaigns, monthly abundance (1995-96 and during three red tide events in Mazatlán Bay. 52 phytoplankton samples with a Bongo net and 64 µm mesh light, during the year 120 water samples with a van Dorn bottle were collected in two sampling stations and from three red tide events. All samples were counted by the inverted-microscope method. The results showed that C. dens was present in the upper Gulf of California and surroundings of Cabo San Lucas. Two peaks were observed during spring and autumn in Mazatlán Bay during 1995-1996. The highest densities (20-360 cells. . l-1 were

Når almenpædagogikken bliver den bedste forbyggelse af angst

DEFF Research Database (Denmark)

Hviid, Pernille; Esbjørn, Barbara Hoff; Villadsen, Jakob Waag

2018-01-01

Formålet med artiklen er at invitere til dialog mellem børneklinisk, almen udviklingspsykologisk og almen pædagogisk praksis med henblik på forebyggelse af angst hos børn. Artiklen forsøger at begrebsliggøre og videreudvikle kvaliteter ved den almene pædagogiske praksis i relation til børneklinis...

Bliv en bedre investor med overblik over den globale økonomi

DEFF Research Database (Denmark)

Risager, Ole

2012-01-01

Fremgangen i den globale økonomi og de nye tiltag i euroområdet har fået optimismen til at spire på aktiemarkederne. Ole Risager, professor på CBS, giver dig her overblikket over, hvordan økonomien på verdensmarkedet ser ud lige nu, og hvordan du - med denne indsigt - placerer dine sparepenge bed...

Urine metabolic profiling for the pathogenesis research of erosive oral lichen planus.

Science.gov (United States)

Li, Xu-Zhao; Yang, Xu-Yan; Wang, Yu; Zhang, Shuai-Nan; Zou, Wei; Wang, Yan; Li, Xiao-Nan; Wang, Ling-Shu; Zhang, Zhi-Gang; Xie, Liang-Zhen

2017-01-01

Oral lichen planus (OLP) is a relatively common chronic immune-pathological and inflammatory disease and potentially oral precancerous lesion. Erosive OLP patients show the higher rate of malignant transformation than patients with non-erosive OLP. Identifying the potential biomarkers related to erosive OLP may help to understand the pathogenesis of the diseases. Metabolic profiles were compared in control and patient subjects with erosive OLP by using ultra-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF-MS) coupled with pattern recognition methods An integrative analysis was used to identify the perturbed metabolic pathways and pathological processes that may be associated with the disease. In total, 12 modulated metabolites were identified and considered as the potential biomarkers of erosive OLP. Multiple metabolic pathways and pathological processes were involved in erosive OLP. The dysregulations of these metabolites could be used to explain the pathogenesis of the disease, which could also be the potential therapeutic targets for the disease. Copyright © 2016 Elsevier Ltd. All rights reserved.

Immune Dysfunction and the Pathogenesis of AIDS-associated non-Hodgkin's Lymphoma

Directory of Open Access Journals (Sweden)

Martínez-Maza Otoniel

1998-01-01

Full Text Available Much has been learned about how HIV-induced immune dysfunction contributes to B cell hyperactivation, and potentially, to the pathogenesis of AIDS-lymphoma. However, further studies are needed to fully understand how HIV infection and immune dysfunction promote B cell hyperactivation and the development/growth of AIDS-lymphoma. In particular, studies are needed to define the role of HHV8 vIL6, IL6 receptor-expression, and lymphocyte surface stimulatory molecules, in promoting B cell hyperactivation or lymphoma cell growth.

Den visuelle oplevelses økonomi – klassisk, neoklassisk, relationel

DEFF Research Database (Denmark)

Michelsen, Anders Ib

2009-01-01

Det foreliggende kapitel søger kortfattet at skitsere en relation mellem visuel kultur og økonomi, som i videre forstand er et konkret input til en mulig teori om vi- suel kulturøkonomi. Med udgangspunkt i en sammenstilling af Johann P. Arnasons teori om en ”kulturel artikulation af verden” med P...... kulturøkonomi, der går ud over den traditionelle diskrepans mel- lem kulturbegreber, fx af antropologisk art, og økonomibegreber, fx af neoklassisk art....

A comparison of photograph-interpreted and IfSAR-derived maps of polar bear denning habitat for the 1002 Area of the Arctic National Wildlife Refuge, Alaska

Science.gov (United States)

Durner, George M.; Atwood, Todd C.

2018-05-11

Polar bears (Ursus maritimus) in Alaska use the Arctic National Wildlife Refuge (ANWR) for maternal denning. Pregnant bears den in snow banks for more than 3 months in winter during which they give birth to and nurture young. Denning is one of the most vulnerable times in polar bear life history as the family group cannot simply walk away from a disturbance without jeopardizing survival of newly born cubs. The ANWR includes the “1002 Area”, a region recently opened for oil and gas exploration by the U.S. Department of the Interior (DOI). As a part of its mission, the DOI “… protects and manages the Nation's natural resources …” and is therefore responsible for conserving polar bears and encouraging development of energy potential. Because future industrial activities could overlap habitats used by denning polar bears, identifying these habitats can inform the decisions of resource managers tasked to develop resources and protect polar bears. To help inform these efforts, we qualitatively compared the distribution of denning habitat identified by two different methods: previously published habitat from manual interpretation of aerial photographs, and habitat derived by computer interrogation of interferometric synthetic aperture radar (IfSAR) digital terrain models (DTM). Because photograph-interpreted methods depicted denning habitat as a line and IfSAR-derived methods depicted habitat as a polygon, we assessed agreement between the two methods with distance measurements. We found that 77.5 percent of IfSAR-derived denning habitat (79.6 km2 ; 1.2 percent of the 6,837.0 km2 1002 Area) was within 600 m of photograph-interpreted habitat (3,026.9 km), including 53.9 percent within 200 m. This distribution differed from that of randomly distributed points, as only 49.4 percent of these occurred within 600 m of photograph-interpreted habitat, including 18.3 percent within 200 m. Both methods appear to identify the major physiographic features that polar bears

MDS: Recent progress in molecular pathogenesis and clinical aspects.

Science.gov (United States)

Harada, Hironori

2017-01-01

Myelodysplastic syndromes (MDS) are defined as hematopoietic stem cell disorders caused by various gene abnormalities. Recent analysis using next generation sequencing has provided great progress in identifying relationships between gene mutations and clinical phenotypes of MDS. It is estimated that one or more gene mutations occur in greater than 90% of MDS patients. More than 50 gene mutations affecting RNA splicing machinery, DNA methylation, histone modifications, transcription factors, signal transduction proteins, and components of the cohesion complex participate in the pathogenesis of MDS. The sequential accumulation of additional cooperating mutations drives disease evolution from clonal hematopoiesis of indeterminate potential (CHIP) to symptomatic MDS and from MDS to acute myelogenous leukemia (AML). Mutations in RNA splicing and DNA methylation occur early and are considered founding mutations, whereas others that occur later are regarded as subclonal mutations. RUNX1 mutations are more likely to be subclonal; however, they apparently play a pivotal role in familial MDS. In addition, large alterations of chromosomes are involved in the pathogenesis of MDS. 5q- syndrome, which leads to haploinsufficiency of the located genes, has consistent clinical features. Understanding gene abnormalities of MDS patients can provide clinical information, including diagnosis, prognostic score, and prediction of response to therapy.

Pathogenesis of Nonsteroidal Anti-Inflammatory Drug Gastropathy: Clues to Preventative Therapy

Directory of Open Access Journals (Sweden)

Salim MA Bastaki

1999-01-01

Full Text Available Gastric ulceration and bleeding are major impediments to the chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs. The development of effective therapies for prevention of these adverse effects requires better understanding of their pathogenesis. Several features of NSAIDs contribute to the development of damage in the stomach, including the topical irritant effects of these drugs on the epithelium, impairment of the barrier properties of the mucosa, suppression of gastric prostaglandin synthesis, reduction of gastric mucosal blood flow and interference with the repair of superficial injury. The presence of acid in the lumen of the stomach also contributes to the pathogenesis of NSAID-induced ulcers and bleeding in a number of ways. Acid impairs the restitution process, interferes with hemostasis and can inactivate several growth factors that are important in mucosal integrity and repair. Profound suppression of gastric acid secretion has been shown to be effective in preventing NSAID-induced ulceration. There is a strong possibility that new NSAIDs entering the market will have greatly reduced toxicity in the gastrointestinal tract.

Arousal from sleep: implications for obstructive sleep apnea pathogenesis and treatment.

Science.gov (United States)

Eckert, Danny J; Younes, Magdy K

2014-02-01

Historically, brief awakenings from sleep (cortical arousals) have been assumed to be vitally important in restoring airflow and blood-gas disturbances at the end of obstructive sleep apnea (OSA) breathing events. Indeed, in patients with blunted chemical drive (e.g., obesity hypoventilation syndrome) and in instances when other defensive mechanisms fail, cortical arousal likely serves an important protective role. However, recent insight into the pathogenesis of OSA indicates that a substantial proportion of respiratory events do not terminate with a cortical arousal from sleep. In many cases, cortical arousals may actually perpetuate blood-gas disturbances, breathing instability, and subsequent upper airway closure during sleep. This brief review summarizes the current understanding of the mechanisms mediating respiratory-induced cortical arousal, the physiological factors that influence the propensity for cortical arousal, and the potential dual roles that cortical arousal may play in OSA pathogenesis. Finally, the extent to which existing sedative agents decrease the propensity for cortical arousal and their potential to be therapeutically beneficial for certain OSA patients are highlighted.

Pathogenesis of Parkinson's disease

OpenAIRE

Riederer, Peter; Lange, Klaus W.

1992-01-01

The importance of genetic aspects, ageing, environmental factors, head trauma, defective mitochondrial respiration, altered iron metabolism, oxidative stress and glutamatergic overactivity of the basal ganglia in the pathogenesis of Parkinson's disease (PD) are considered in this review.

Jacobsens ukendte samling af stensager fra den græske oldtid. Obsidian, økser, matricer, ansigtssten og andre sjældne oldsager

DEFF Research Database (Denmark)

Sørensen, Lasse

2012-01-01

Jacobsens ukendte samling af stensager fra den græske oldtid. Obsidian, økser, matricer, ansigtssten og andre sjældne oldsager......Jacobsens ukendte samling af stensager fra den græske oldtid. Obsidian, økser, matricer, ansigtssten og andre sjældne oldsager...

Understanding healthful eating from a salutogenic perspective

NARCIS (Netherlands)

Swan, E.C.

2016-01-01

The biomedical model of health orients towards pathogenesis, the study of disease origins and causes. The starting point is to understand determinants of ill-health, and health is defined in this model as the absence of disease. When applied to nutrition research, the underlying assumption is

The utopian challenge to global capitalism by Walter van den Broeck in Terug naar Walden

Directory of Open Access Journals (Sweden)

Andries Visagie

2012-12-01

Full Text Available The socialist sympathies that inform the writing of Flemish author Walter van den Broeck align him with a well-established tradition of socially engaged writing in Flanders. In his novel Terug naar Walden (Back to Walden, published in 2009, he revisits the Walden project of the Dutch reformer and writer Frederik van Eeden (1860−1932. Van den Broeck suggests that a reconsideration of the socialist ideals that inspired Van Eeden to establish settlements in the Netherlands and the United States is warranted in the light of the economic crisis triggered by unchecked capitalist practices in 2008. In Terug naar Walden Ruler Marsh, the richest man in the world, unleashes a global financial crisis as a form of retaliation against the capitalist system that ruined his parents. Marsh returns to the Kempen in Flanders where his family originated. In a Heideggerean affirmation of the local as exemplified by the country road, Van den Broeck articulates his vision of the common, that theorists Michael Hardt and Antonio Negri in their Empire trilogy have attempted to salvage from communist thinking, with a utopian notion that a stronger connection with the land and the people within one’s immediate environment may provide a useful premise for the development of viable alternatives to capitalism.

Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis

DEFF Research Database (Denmark)

Thorsteinsdottir, Sigrun; Gudjonsson, Thorkell; Nielsen, Ole Haagen

2011-01-01

on the current understanding of the pathogenesis of ulcerative colitis-associated colorectal cancer and how this knowledge can be transferred into patient management to assist clinicians and pathologists in identifying patients with ulcerative colitis who have an increased risk of colorectal cancer. Inflammation......One of the most serious complications of ulcerative colitis is the development of colorectal cancer. Screening patients with ulcerative colitis by standard histological examination of random intestinal biopsy samples might be inefficient as a method of cancer surveillance. This Review focuses......-driven mechanisms of DNA damage, including the generation and effects of reactive oxygen species, microsatellite instability, telomere shortening and chromosomal instability, are reviewed, as are the molecular responses to genomic stress. We also discuss how these mechanisms can be translated into usable biomarkers...

Bezūdens kalcija hidrogēnfosfāta izmantošana zopiklona tablešu ražošanā

OpenAIRE

Kūms, Uģis

2015-01-01

Bezūdens kalcija hidrogēnfosfāts ir plaši izmantota palīgviela, ko izmanto farmācijā, medicīnā un pārtikas ražošanā. Bezūdens kalcija hidrogēnfosfāts nodrošina zopiklona tablešu presēšanās spēju, bet tā fizikāli-tehnoloģiskās īpašības var ietekmēt tabletes mehānisko izturību un pašu tabletes ražošanas procesu. Šajā darbā tika pētīta bezūdens kalcija hidrogēnfosfāta ietekme uz izplatītu nebenzodiazepīna klases miega līdzekli zopiklonu tablešu kvalitatīvajiem rādītājiem. Bezūdens kalcija hid...

Pathogenesis and treatment of HIV-1 infection: recent developments (Y2K update).

Science.gov (United States)

Dewhurst, S L; da Cruz, R L; Whetter, L

2000-01-01

Human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of acquired immunodeficiency syndrome (AIDS). The pathogenesis of HIV-1-induced disease is complex and characterized by the interplay of both viral and host factors, which together determine the outcome of infection. An improved understanding of the pathogenic mechanisms of AIDS, combined with recent insights into the dynamics of viral infection may provide powerful new opportunities for therapeutic intervention against this virus.

Etiology and pathogenesis of antisperm antibody

Directory of Open Access Journals (Sweden)

farhad Shahsavar

2011-06-01

Full Text Available Antisperm antibodies (ASA occur in men and women and may significantly impair fertility. In this case, the testis is an immunologically privileged site where germ cell antigens are protected from autoimmune attack. However, due to disruption of the blood-testis barrier occurring from testicular injury, or as a consequence of trauma to the epididymis or vas deferens many testicular proteins get autoantigenic during immunological challenges resulting in the formation of ASA in the blood serum, seminal plasma or located on the sperm membrane. ASA have also been reported to be associated with inflammation, cryptorchidism, varicocele and surgical intervention in the genital organs. ASA may interfere with different sperm functions, which are essential for the fertilization process.This review article will help to increase our understanding of the specific mechanisms that elicit the autoimmune response to sperm and of the pathogenesis of ASA that leads to an antibody-mediated infertility.

UV mutagenesis in E. coli with excision repair initiated by uvrABC or denV gene products

Energy Technology Data Exchange (ETDEWEB)

Bockrath, R; Hodes, M Z; Mosbaugh, P; Valerie, K; de Riel, J K

1988-03-01

Mutation frequency responses produced by ultraviolet light are compared in 4 closely related strains of E.coli B/r having the same tyr(Oc) allele and different excision-repair capabilities. The production of Tyr/sup +/ prototrophic mutants is classified into back-mutations and de novo or converted glutamine tRNA suppressor mutations to indicate different mutation events. Cells transformed with the plasmid pdenV-7 require larger exposures than the parent strains to produce comparable mutation frequency responses, indicating that DenV activity can repair mutatagenic photoproducts. When damage reduction by UvrABC or DenV is compared for each of the specific categories of mutation, the results are consistent with the idea that pyrimidine dimers infrequently or never target back-mutations of this allele, frequently target the de novo suppressor mutations, and extensively or exclusively target the converted suppressor mutations. This analysis is based on the distinction that UvrABC-initiated excision repair recognizes dimer and non-dimer photoproducts but that DenV-initiated repair recognizes only pyrimidine dimers. 44 refs.; 3 figs.; 2 tabs.

Where to deliver baits for deworming urban red foxes for Echinococcus multilocularis control: new protocol for micro-habitat modeling of fox denning requirements.

Science.gov (United States)

Ikeda, Takako; Yoshimura, Masashi; Onoyama, Keiichi; Oku, Yuzaburo; Nonaka, Nariaki; Katakura, Ken

2014-08-06

Deworming wild foxes by baiting with the anthelmintic praziquantel is being established as a preventive technique against environmental contamination with Echinococcus multilocularis eggs. Improvement of the cost-benefit performance of baiting treatment is required urgently to raise and maintain the efficacy of deworming. We established a spatial model of den site selection by urban red foxes, the definitive host, to specify the optimal micro-habitats for delivering baits in a new modeling approach modified for urban fox populations. The model was established for two cities (Obihiro and Sapporo) in Hokkaido, Japan, in which a sylvatic cycle of E. multilocularis is maintained. The two cities have different degrees of urbanization. The modeling process was designed to detect the best combination of key environmental factors and spatial scale that foxes pay attention to most (here named 'heeding range') when they select den sites. All possible models were generated using logistic regression analysis, with "presence" or "absence" of fox den as the objective variable, and nine landscape categories customized for urban environments as predictor variables to detect the best subset of predictors. This procedure was conducted for each of ten sizes of concentric circles from dens and control points to detect the best circle size. Out of all models generated, the most parsimonious model was selected using Akaike's Information Criterion (AIC) inspection. Our models suggest that fox dens in Obihiro are located at the center of a circle with 500 m radius including low percentages of wide roads, narrow roads, and occupied buildings, but high percentages of green covered areas; the dens in Sapporo within 300 m radius with low percentages of wide roads, occupied buildings, but high percentages of riverbeds and green covered areas. The variation of the models suggests the necessity of accumulating models for various types of cities in order to reveal the patterns of the model. Our

A Rare Bilateral Presentation of Multiple Dens Invaginatus, Shovel-Shaped Incisor and Talon Cusp With Mesiodens.

Science.gov (United States)

Hegde, S; Jain, M; Shubha, A B

2014-01-01

The aim of this paper is to describe a unique and unusual case of concomitant appearance of morphological dental anomalies in the maxillary anterior region, along with its management in a patient with no systemic abnormality. This case report describes the clinical and radiographic features of talon cusp, dens invaginatus, shovel-shaped incisors and a supernumerary tooth occurring in a single patient, which is a rare presentation. All 4 permanent maxillary incisors had dens invaginatus, the permanent maxillary canines showed the presence of talon cusps, the permanent maxillary central incisors were shovel-shaped and an erupted mesiodens was also observed. Treatment included restorative, surgical and orthodontic approaches.

Tryptophan-induced pathogenesis of breast cancer | Cao | African ...

African Journals Online (AJOL)

Background: The pathogenesis of breast cancer remains unclear. Aims: To investigate the pathogenesis of breast cancer through targeted metabolomics of amino acids components in serum of patients with breast cancer. Methods: Patients with breast cancers were enrolled in our hospital between year January 1st, 2013 ...

Cellular Aspects of Shigella Pathogenesis: Focus on the Manipulation of Host Cell Processes.

Science.gov (United States)

Killackey, Samuel A; Sorbara, Matthew T; Girardin, Stephen E

2016-01-01

Shigella is a Gram-negative bacterium that is responsible for shigellosis. Over the years, the study of Shigella has provided a greater understanding of how the host responds to bacterial infection, and how bacteria have evolved to effectively counter the host defenses. In this review, we provide an update on some of the most recent advances in our understanding of pivotal processes associated with Shigella infection, including the invasion into host cells, the metabolic changes that occur within the bacterium and the infected cell, cell-to-cell spread mechanisms, autophagy and membrane trafficking, inflammatory signaling and cell death. This recent progress sheds a new light into the mechanisms underlying Shigella pathogenesis, and also more generally provides deeper understanding of the complex interplay between host cells and bacterial pathogens in general.

A potential role of Chlamydia pneumoniae in the pathogenesis of periodontal disease in adolescents and adults.

Science.gov (United States)

Ajonuma, Louis Chukwuemeka

2010-01-01

Periodontal diseases are among the most common human infections that not only impact oral health but also are associated with adverse systemic diseases such as cardiovascular diseases, stroke, diabetes, and respiratory diseases. Periodontal diseases is a chronic severe inflammatory process of the gingiva leading to the destruction of tooth-supporting structures, alveolar bone, and subsequently tooth loss due to bacteria infection. While it has been reported that several oral biofilm-forming bacteria might be involved, the role of C. pneumoniae infection in the pathogenesis of periodontal disease remains unknown. The present hypothesis proposes that C. pneumoniae is involved in the pathogenesis of periodontal diseases. This will lead to a better understanding of the etiopathogenesis of periodontal disease, better treatment strategy and savings on total health care costs.

Pathogenesis of Nervous and Mental Diseases in Children.

Science.gov (United States)

Harms, Ernest, Ed.

Major pathogenic sources of mental diseases in children and a classification of these diseases are considered. Contributions include the following: pathogenesis of mental diseases in childhood by Ernest Harms, organ inferiority and psychiatric disorders by Bernard Shulman and Howard Klapman, pathogenesis of neurological disorders by George Gold,…

Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis.

Science.gov (United States)

Lupia, Enrico; Pigozzi, Luca; Goffi, Alberto; Hirsch, Emilio; Montrucchio, Giuseppe

2014-11-07

A large body of experimental and clinical data supports the notion that inflammation in acute pancreatitis has a crucial role in the pathogenesis of local and systemic damage and is a major determinant of clinical severity. Thus, research has recently focused on molecules that can regulate the inflammatory processes, such as phosphoinositide 3-kinases (PI3Ks), a family of lipid and protein kinases involved in intracellular signal transduction. Studies using genetic ablation or pharmacologic inhibitors of different PI3K isoforms, in particular the class I PI3Kδ and PI3Kγ, have contributed to a greater understanding of the roles of these kinases in the modulation of inflammatory and immune responses. Recent data suggest that PI3Ks are also involved in the pathogenesis of acute pancreatitis. Activation of the PI3K signaling pathway, and in particular of the class IB PI3Kγ isoform, has a significant role in those events which are necessary for the initiation of acute pancreatic injury, namely calcium signaling alteration, trypsinogen activation, and nuclear factor-κB transcription. Moreover, PI3Kγ is instrumental in modulating acinar cell apoptosis, and regulating local neutrophil infiltration and systemic inflammatory responses during the course of experimental acute pancreatitis. The availability of PI3K inhibitors selective for specific isoforms may provide new valuable therapeutic strategies to improve the clinical course of this disease. This article presents a brief summary of PI3K structure and function, and highlights recent advances that implicate PI3Ks in the pathogenesis of acute pancreatitis.

Udbredelse af den baktielle zoonose i danske kvægbesætninger

DEFF Research Database (Denmark)

Bødker, Rene; Christoffersen, Anna-Bodil

2008-01-01

Tankmælksprøver fra 742 mælkeleverende kvægejendomme blev analyseret for antistoffer mod Coxiella burnetii i en ELISA. 57% af ejendommene havde positive prøver i den serologiske test. Prøverne var diagnostiske indsendelser til DTU Veterinærinstituttet og udgjorde derfor ikke en repræsentativ...

Disque denúncia como fonte de informações para análises criminais na Região Metropolitana de Salvador 2006-2011

OpenAIRE

Portella, Daniel Deivson Alves

2013-01-01

Introdução: O tráfico de drogas pode ser considerado como um dos fatores determinantes para o aumento de homicídios nas metrópoles e nas regiões metropolitanas. A grande frequência de crimes contribuiu para que a população passasse a fazer denúncias anônimas sobre os fatos criminosos através do programa Disque Denúncia,implantado na Bahia desde 2005. Objetivos: Analisar o Disque Denúncia como fonte de informações para análises criminais na Região Metropolitana de Salvador (RMS) de 2006-2011 e...

Da du trengte en neste, var den der? : kirke og abortproblematikk i Norge mellom 1970 og 2013

OpenAIRE

Meland, Ragnhild Elisabeth Risanger

2013-01-01

Debatten om abort i Norge har vært nært knyttet til gjeldende abortlover. Kirkens engasjement har i stor grad kretset rundt motstand mot abortloven, både før og etter den ble vedtatt. Loven om selvbestemt abort i Norge har tross motstand stått stødig siden den ble vedtatt i 1978. Loven er blitt en selvfølgelighet, selv om det stilles spørsmål til abortpraksisen fra tid til annen. Det er en viss enighet i befolkningen og i de politiske partier om at høye aborttall ikke er ø...

Meet the Predators: the Branding Practices behind Dragons’ Den, Shark Tank, and Höhle der Löwen

Directory of Open Access Journals (Sweden)

Sabine Baumann

2016-08-01

Full Text Available The TV industry has traditionally relied on advertising and subscription fees for revenue. Recently, brand extensions and co-branding strategies have been rediscovered as income sources. A prominent example of such a strategy is the TV format Dragons’ Den, which has been locally produced in many different countries. We use this intriguing case to explore the extensive and intricate co-branding relationships and brand extensions in the business-to-consumer and the business-to-business settings of TV companies. Our paper analyses global adaptations and cultural branding of Dragons’Den; in particular, brand extensions and co-branding strategies.

Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment.

LENUS (Irish Health Repository)

Stevens, Niall T

2012-12-01

The insertion of medical devices, such as intraventricular shunts, is often complicated by infection leading to ventriculitis. Frequently, such infections result from colonisation and subsequent biofilm formation on the surfaces of the shunts by Staphylococcus epidermidis. The pathogenesis of neurosurgical shunt-related infection is complex with interactions between the pathogen, the device and the unique local immunological environment of the central nervous system (CNS). An ability to form biofilm, the main virulence determinant of Staphylococcus epidermidis, facilitates protection of the organism from the host defences while still initiating an immunological response. The presence of the blood brain barrier (BBB) and the biofilm itself also complicates treatment, which presents many challenges when managing shunt infections. A greater understanding of the interplay between S. epidermidis and the CNS could potentially improve the diagnosis, treatment and management of such infections. This review describes the pathogenesis, treatment and implications of S. epidermidis ventriculoperitoneal shunt-related infections, concentrating on recent research and the implications for treatment.

Molecular Pathogenesis of Spondyloarthritis

DEFF Research Database (Denmark)

Carlsen, Thomas Gelsing

This dissertation includes a presentation of knowledge on the molecular pathogenesis of spondyloarthritis achieved through a PhD programme at Aalborg University from 1.12.2011 - 1.12.2014. Work was carried out in the Laboratory of Medical Mass Spectrometry, headed by: Professor Svend Birkelund...

Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention.

Science.gov (United States)

Brojer, Ewa; Husebekk, Anne; Dębska, Marzena; Uhrynowska, Małgorzata; Guz, Katarzyna; Orzińska, Agnieszka; Dębski, Romuald; Maślanka, Krystyna

2016-08-01

Fetal/neonatal alloimmune thrombocytopenia (FNAIT) is a relatively rare condition (1/1000-1/2000) that was granted orphan status by the European Medicines Agency in 2011. Clinical consequences of FNAIT, however, may be severe. A thrombocytopenic fetus or new-born is at risk of intracranial hemorrhage that may result in lifelong disability or death. Preventing such bleeding is thus vital and requires a solution. Anti-HPA1a antibodies are the most frequent cause of FNAIT in Caucasians. Its pathogenesis is similar to hemolytic disease of the newborn (HDN) due to anti-RhD antibodies, but is characterized by platelet destruction and is more often observed in the first pregnancy. In 75 % of these women, alloimmunization by HPA-1a antigens, however, occurs at delivery, which enables development of antibody-mediated immune suppression to prevent maternal immunization. As for HDN, the recurrence rate of FNAIT is high. For advancing diagnostic efforts and treatment, it is thereby crucial to understand the pathogenesis of FNAIT, including cellular immunity involvement. This review presents the current knowledge on FNAIT. Also described is a program for HPA-1a screening in identifying HPA-1a negative pregnant women at risk of immunization. This program is now performed at the Institute of Hematology and Transfusion Medicine in cooperation with the Department of Obstetrics and Gynecology of the Medical Centre of Postgraduate Education in Warsaw as well as the UiT The Arctic University of Norway.

Modern concepts of pathogenesis of ichthyosis

Directory of Open Access Journals (Sweden)

Світлана Володимирівна Дмитренко

2015-06-01

Full Text Available The modern concepts of ichthyosis are rather ambiguous and need more precise definition. The modern conception of pathogenesis of ichthysosis is offered and considered in this article.Aim. An aim is to analyze received data of our researches about molecular disturbances of keratin on the background of ichthyosis and the current data on the pathogenesis of disease.Materials and methods. An analysis of the results of research in 70 patients with ichthyosis by the methods of the flow cytometry, immunohistochemistry and by immunologic methods is presented in an article.Results. Authors revealed molecular, immunologic and immunohistochemical changes that realizes the disturbance of keratinization on the background of this disease. The model of pathogenesis of the various manifestations of gene mutations that causes ichthyosis is proposed and it can be taken into account when elaborating the new directions of therapy.Conclusions. Gene mutations that cause ichthyosis realizes on the background of disturbance of the cell cycle causing cornification and disturb the local and general immune reactions that summarily lead to the clinical presentations of disease. 

Den vitalistiske strømning i dansk litteratur omkring år 1900

DEFF Research Database (Denmark)

Dam, Anders Ehlers

nylæsninger deres værker i spil med århundredskiftets billedkunst og musik, repræsenteret af J.F. Willumsen og Carl Nielsen. Den livsdyrkende kunst i Danmark sættes desuden ind i sin internationale idéhistoriske sammenhæng. Her er de tyske filosoffer Arthur Schopenhauer og Friedrich Nietzsche i fokus....

Synet på døden i Grundtvigs gendigtninger af gammeltestamentlige tekster

DEFF Research Database (Denmark)

Nielsen, Kirsten

2013-01-01

i den gammelnordiske betydning: dødsriget. Resultatet bliver, at Grundtvig, der ellers ikke er tilbageholdende med at tale om Djævelen og Helvede, kun meget sjældent gør det, når han gendigter en gammeltestamentlig tekst. Grundtvig er således loyal over for sit gammeltestamentlige forlæg, hvilket...

The role of the apelinergic and vasopressinergic systems in the regulation of the cardiovascular system and the pathogenesis of cardiovascular disease.

Science.gov (United States)

Czarzasta, Katarzyna; Cudnoch-Jedrzejewska, Agnieszka

2014-01-01

Research studies indicate a role of the apelinergic and vasopressinergic systems both in the regulation of the cardiovascular system and the pathogenesis of CVD, including in such settings as obesity and stress. Based on these data, it may be suggested that interactions between these systems underlie numerous physiological and pathophysiological processes, some of them related to the cardiovascular system. Better understanding of the role of these systems and their interactions, both physiological and related to the pathogenesis of CVD, will allow further advances in prevention and drug therapy.

Cardiac Hemodynamics in the Pathogenesis of Congenital Heart Disease and Aortic Valve Calcification

Science.gov (United States)

Nigam, Vishal

2011-11-01

An improved understanding of the roles of hemodynamic forces play in cardiac development and the pathogenesis of cardiac disease will have significant scientific and clinical impact. I will focus on the role of fluid dynamics in congenital heart disease and aortic valve calcification. Congenital heart defects are the most common form of birth defect. Aortic valve calcification/stenosis is the third leading cause of adult heart disease and the most common form of acquired valvular disease in developed countries. Given the high incidence of these diseases and their associated morbidity and mortality, the potential translational impact of an improved understanding of cardiac hemodynamic forces is very large. Division of Pediatric Cardiology, Rady Children's Hospital, San Diego

Understanding Schizophrenia

DEFF Research Database (Denmark)

Henriksen, Mads Gram

2012-01-01

Indenfor den biologiske psykiatri opfattes skizofrene symptomer såsom bizarre vrangforestillinger og verbale hallucinationer som kausale udfald af genetisk nedarvede biologiske abnormiteter. Denne fremherskende monokausale opfattelse af skizofreni afspejler en udbredt ambition om at forankre psyk...

SensInDenT-Noncontact Sensors Integrated Into Dental Treatment Units.

Science.gov (United States)

Teichmann, Daniel; Teichmann, Maren; Weitz, Philippe; Wolfart, Stefan; Leonhardt, Steffen; Walter, Marian

2017-02-01

This paper presents the first system design (SensInDenT) for noncontact cardiorespiratory monitoring during dental treatment. The system is integrated into a dental treatment unit, and combines sensors based on electromagnetic, optical, and mechanical coupling at different sensor locations. The measurement principles and circuits are described and a system overview is presented. Furthermore, a first proof of concept is provided by taking measurements in healthy volunteers under laboratory conditions.

At Forberede sig til den mundtlige prøve ( kap12)

DEFF Research Database (Denmark)

Nørgaard, Britta Kusk

2015-01-01

Et opslagsværk for studerende til støtte for bacheloropgaveskrivning. Klæd dine studerende på til at skrive den store afsluttende opgave. De studerende får med denne bog et gedigent opslagsværk, som giver svar på alle de spørgsmål, det typisk trænger sig på, når bacheloropgaven skal påbegyndes. B...

Refrigeration compressor for the mobile application; Kaeltemittelverdichter fuer den mobilen Einsatz

Energy Technology Data Exchange (ETDEWEB)

Hagenlocher, T. [Bock GmbH und Co. Kaeltemaschinenfabrik, Frickenhausen (Germany)

2000-06-01

The mobile use of cooling air conditioning systems is increasingly important. Main component of this system is the refrigeration compressor. The special requirement for the compressor as well for the resulting boundary conditions are discussed. (orig.) [German] Der mobile Einsatz von Kaelte- und Klimaanlagen gewinnt zunehmend an Bedeutung. Wichtigste Komponente dieser Anlage ist der Kaeltemittelverdichter. Die speziellen Anforderungen an den Verdichter sowie an die daraus resultierenden Randbedingungen werden dargestellt. (orig.)

Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver Parenchymal and Nonparenchymal Cells

Directory of Open Access Journals (Sweden)

Nancy Magee

2016-01-01

Full Text Available Nonalcoholic fatty liver disease (NAFLD is the most common type of chronic liver disease in the Western countries, affecting up to 25% of the general population and becoming a major health concern in both adults and children. NAFLD encompasses the entire spectrum of fatty liver disease in individuals without significant alcohol consumption, ranging from nonalcoholic fatty liver (NAFL to nonalcoholic steatohepatitis (NASH and cirrhosis. NASH is a manifestation of the metabolic syndrome and hepatic disorders with the presence of steatosis, hepatocyte injury (ballooning, inflammation, and, in some patients, progressive fibrosis leading to cirrhosis. The pathogenesis of NASH is a complex process and implicates cell interactions between liver parenchymal and nonparenchymal cells as well as crosstalk between various immune cell populations in liver. Lipotoxicity appears to be the central driver of hepatic cellular injury via oxidative stress and endoplasmic reticulum (ER stress. This review focuses on the contributions of hepatocytes and nonparenchymal cells to NASH, assessing their potential applications to the development of novel therapeutic agents. Currently, there are limited pharmacological treatments for NASH; therefore, an increased understanding of NASH pathogenesis is pertinent to improve disease interventions in the future.

Exosomes in Human Immunodeficiency Virus Type I Pathogenesis: Threat or Opportunity?

Directory of Open Access Journals (Sweden)

Sin-Yeang Teow

2016-01-01

Full Text Available Nanometre-sized vesicles, also known as exosomes, are derived from endosomes of diverse cell types and present in multiple biological fluids. Depending on their cellular origins, the membrane-bound exosomes packed a variety of functional proteins and RNA species. These microvesicles are secreted into the extracellular space to facilitate intercellular communication. Collective findings demonstrated that exosomes from HIV-infected subjects share many commonalities with Human Immunodeficiency Virus Type I (HIV-1 particles in terms of proteomics and lipid profiles. These observations postulated that HIV-resembled exosomes may contribute to HIV pathogenesis. Interestingly, recent reports illustrated that exosomes from body fluids could inhibit HIV infection, which then bring up a new paradigm for HIV/AIDS therapy. Accumulative findings suggested that the cellular origin of exosomes may define their effects towards HIV-1. This review summarizes the two distinctive roles of exosomes in regulating HIV pathogenesis. We also highlighted several additional factors that govern the exosomal functions. Deeper understanding on how exosomes promote or abate HIV infection can significantly contribute to the development of new and potent antiviral therapeutic strategy and vaccine designs.

Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases.

Science.gov (United States)

Dolan, Kyle T; Chang, Eugene B

2017-01-01

The rising incidence of inflammatory bowel diseases in recent decades has notably paralleled changing lifestyle habits in Western nations, which are now making their way into more traditional societies. Diet plays a key role in IBD pathogenesis, and there is a growing appreciation that the interaction between diet and microbes in a susceptible person contributes significantly to the onset of disease. In this review, we examine what is known about dietary and microbial factors that promote IBD. We summarize recent findings regarding the effects of diet in IBD epidemiology from prospective population cohort studies, as well as new insights into IBD-associated dysbiosis. Microbial metabolism of dietary components can influence the epithelial barrier and the mucosal immune system, and understanding how these interactions generate or suppress inflammation will be a significant focus of IBD research. Our knowledge of dietary and microbial risk factors for IBD provides important considerations for developing therapeutic approaches through dietary modification or re-shaping the microbiota. We conclude by calling for increased sophistication in designing studies on the role of diet and microbes in IBD pathogenesis and disease resolution in order to accelerate progress in response to the growing challenge posed by these complex disorders. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Pathogenesis of Dengue Vaccine Viruses in Mosquitoes.

Science.gov (United States)

1980-01-01

1973). Sabin (1948) showed that attenuated dpngiie, passed through mosquitoes, did not revert to pathogenicity frnr man. -7- Thus even if the vaccine ...AD-A138 518 PATHOGENESIS OF DENGUE VACCINE YIRUSES IN MOSQUITOES 1/ (U) YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE B J BEATY ET AL. 9i JAN 80 DRND7...34 ’ UNCLASSIFIED 0{) AD 0Pathogenesis of dengue vaccine viruses in mosquitoes -First Annual Report Barry I. Beaty, Ph.D. Thomas H. G

Case note: EuGH (Az. C-137/09 (Marc Michel Josemans/Burgemeester van Maastricht): Verbot des Zutritts zu Coffeeshops für nicht in den Niederlanden ansässige Personen)

NARCIS (Netherlands)

Purnhagen, K.

2011-01-01

Die Coffeeshops in den Niederlanden sind Einrichtungen, deren Haupttätigkeit im Verkauf von Marihuana und Haschisch besteht. Der Besitz dieser Cannabis-Produkte zum persönlichen Gebrauch ist straffrei und ihr Verkauf wird von den Behörden geduldet. Nach den staatsanwaltlichen Richtlinien dürfen in

New Insights into the Pathogenesis of Pancreatitis

Science.gov (United States)

Sah, Raghuwansh P.; Dawra, Rajinder K.; Saluja, Ashok K.

2014-01-01

Purpose of review In this article, we review important advances in our understanding of the mechanisms of pancreatitis. Recent Findings The relative contribution of intra-pancreatic trypsinogen activation and NFκB activation, the two major early independent cellular events in the etiology of pancreatitis, have been investigated using novel genetic models. Trypsinogen activation has traditionally held the spotlight for many decades as it is believed to be the central pathogenic event of pancreatitis However, recent experimental evidence points to the role of trypsin activation in early acinar cell damage but not in the inflammatory response of acute pancreatitis through NFκB activation. Further, chronic pancreatitis in the caerulein model develops independently of typsinogen activation. Sustained activation of the NFκB pathway, but not persistent intra-acinar expression of active trypsin, was shown to result in chronic pancreatitis. Calcineurin-NFAT signaling was shown to mediate downstream effects of pathologic rise in intracellular calcium. IL-6 was identified as a key cytokine mediating pancreatitis-associated lung injury. Summary Recent advances challenge the long-believed trypsin-centered understanding of pancreatitis. It is becoming increasingly clear that activation of intense inflammatory signaling mechanisms in acinar cells is crucial to the pathogenesis of pancreatitis, which may explain the strong systemic inflammatory response in pancreatitis. PMID:23892538

A regional climate model for the Arctic and the North Atlantic; Ein regionales Klimamodell fuer die Arktis und den Nordatlantik

Energy Technology Data Exchange (ETDEWEB)

Berndt, H

2001-07-01

corresponding a low influence of the lateral boundary conditions. Overall, REMO has proved to be a useful tool for a better understanding of the processes in the Arctic and the North Atlantic. Further adjustment of the parameterizations seems to be necessary. Other components of the climate system have to be considered to successfully describe the complex feedbacks and processes of the climate subsystems. (orig.) [German] Die Arktis und der subpolare Nordatlantik bilden mit ihren komplexen Mechanismen und Rueckkopplungen eine wichtige Komponente unseres Klimasystems. Aufgrund der geringen Beobachtungsdichte und der niedrigen Aufloesung globaler Klimamodelle, bietet sich der Einsatz hoeher aufloesender regionaler Klimamodelle an. Das hier verwendete regionale Klimamodell (REMO) basiert auf dem frueheren Wettervorhersagemodell EM des Deutschen Wetterdienstes (DWD) und wurde am Max-Planck-Institut fuer Meteorologie (MPIfM) in Hamburg weiterentwickelt. Fuer die Simulation subskaliger Prozesse stehen zwei Saetze physikalischer Parametrisierungen zur Verfuegung - die urspruenglich verwendete DWD-Physik und die ECHAM4-Physik des MPIfM. Der dynamische Teil ist in beiden Faellen identisch. REMO wird zunaechst an das neue Untersuchungsgebiet angepasst. Die neue Konfiguration beruecksichtigt bei einer horizontalen Aufloesung von 0.5 x 0.5 und 145 x 121 Glitterpunkten die gesamte Arktis und den Nordatlantik bis etwa 40 N. Mit DWD- und ECHAM4-Physik im Vorhersage- und Klima-Mode werden unterschiedliche Zeitraeume simuliert. Als Antriebsdaten werden die NCEP/NCAR-Reanalysen mit einer zeitlichen Aufloesung von 6 Stunden verwendet. Da REMO bisher nur in gemaessigtem Klima eingesetzt wurde, steht der Test des Modells unter den extremen Bedingungen der hohen Breiten im Vordergrund. Beim Vergleich mit Schiffsbeobachtungen aus der Labrador-See liegt REMO deutlich dichter an den Messungen als die Antriebsdaten. Unrealistisch hohe Feuchten in den Reanalysen sind vermutlich die Ursache erhoehter

[Epidemiology, risk factors and molecular pathogenesis of primary liver cancer].

Science.gov (United States)

Hagymási, Krisztina; Tulassay, Zsolt

2008-03-23

Primary liver cancer is the fifth most common cancer worldwide. Hepatocellular carcinoma accounts for 85-90% of primary liver cancers. Distribution of hepatocellular carcinoma shows variations among geographic regions and ethnic groups. Males have higher liver cancer rates than females. Hepatocellular carcinoma occurs within an established background of chronic liver disease and cirrhosis (70-90%). Major causes (80%) of hepatocellular carcinoma are hepatitis B, C virus infection, and aflatoxin exposition. Its development is a multistep process. We have a growing understanding on the molecular pathogenesis. Genetic and epigenetic changes activate oncogenes, inhibit tumorsuppressor genes, which result in autonomous cell proliferation. The chromosomal instability caused by telomere dysfunction, the growth-retrained environment and the alterations of the micro- and macroenvironment help the expansion of the malignant cells. Understanding the molecular mechanisms could improve the screening of patients with chronic liver disease, or cirrhosis, and the prevention as well as treatment of hepatocellular carcinoma.

Undersøgelse af udviklingen i maksimale vandstande i den østligste del af Limfjorden Aalborg – Hals

DEFF Research Database (Denmark)

Burcharth, Hans Falk; Røge, Mads Sønderstrup

Udviklingen i maksimalvandstande i den veslige del af Limfjorden har påkaldt sig stor interesse i forbindelse med diskussionen om stigende oversvømmelsesfrekvens relateret til en eventuel klimaændring. Formålet med nærværende undersøgelse er at belyse udviklingen i maksimalvandstande i den østlig...... østligste del af Limfjorden på strækningen fra Aalborg til Hals, en strækning hvor der er lavtliggende områder på begge sider af fjorden. Målinger af højvandstande i Aalborg er foretaget siden 1944 og i Hals siden april 2002....

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

International Nuclear Information System (INIS)

Yao Hongwei; Rahman, Irfan

2011-01-01

Chronic obstructive pulmonary disease (COPD) is a global health problem. The current therapies for COPD are poorly effective and the mainstays of pharmacotherapy are bronchodilators. A better understanding of the pathobiology of COPD is critical for the development of novel therapies. In the present review, we have discussed the roles of oxidative/aldehyde stress, inflammation/immunity, and chromatin remodeling in the pathogenesis of COPD. An imbalance of oxidants/antioxidants caused by cigarette smoke and other pollutants/biomass fuels plays an important role in the pathogenesis of COPD by regulating redox-sensitive transcription factors (e.g., NF-κB), autophagy and unfolded protein response leading to chronic lung inflammatory response. Cigarette smoke also activates canonical/alternative NF-κB pathways and their upstream kinases leading to sustained inflammatory response in lungs. Recently, epigenetic regulation has been shown to be critical for the development of COPD because the expression/activity of enzymes that regulate these epigenetic modifications have been reported to be abnormal in airways of COPD patients. Hence, the significant advances made in understanding the pathophysiology of COPD as described herein will identify novel therapeutic targets for intervention in COPD.

Die Entstehung des „Judenbildes“ in den Alltagsmedien des 19. Jahrhunderts

Directory of Open Access Journals (Sweden)

Ute Wrocklage

2001-07-01

Full Text Available In der zweiten Hälfte des 19. Jahrhunderts beginnen, Illustratoren und Zeichner von Bildwitzen und Karikaturen das stereotype und in der Folge antisemitische Bild vom Juden herauszubilden. Es findet schnell Eingang in die illustrierten Zeitschriften und Bilderbögen der Zeit. In diesen drei untersuchten Bildmedien kennzeichnen neben der Physiognomie diskriminierende Attribute den Juden als Typus. Dieser Entwicklung und der Herausbildung der Stereotype zum antisemitischen Judenbild geht die Arbeit nach.

Demonstrating concepts of pathogenesis using effectors of Phytophthora infestans

Science.gov (United States)

Pathogenesis, or how pathogens cause disease, is an important concept in plant pathology. The study of pathogenesis in plant pathology has rapidly expanded and is now a significant portion of plant pathology research (especially research at the molecular level of host-pathogen interaction). With the...

Reinkarnation er blot én af mange fantasier om et liv efter døden

DEFF Research Database (Denmark)

Aktor, Mikael

2015-01-01

Den tidlige kristendom udviklede sig i et miljø, hvor reinkarnationstanker ikke var ualmindelige. Kun gennem en intern teologisk forhandling i de kristne miljøer udskiltes disse tanker efterhånden som “kætterier”....

β-Cell Autophagy in Diabetes Pathogenesis.

Science.gov (United States)

Marasco, Michelle R; Linnemann, Amelia K

2018-05-01

Nearly 100 years have passed since Frederick Banting and Charles Best first discovered and purified insulin. Their discovery and subsequent improvements revolutionized the treatment of diabetes, and the field continues to move at an ever-faster pace with respect to unique treatments for both type 1 and type 2 diabetes. Despite these advances, we still do not fully understand how apoptosis of the insulin-producing β-cells is triggered, presenting a challenge in the development of preventative measures. In recent years, the process of autophagy has generated substantial interest in this realm due to discoveries highlighting its clear role in the maintenance of cellular homeostasis. As a result, the number of studies focused on islet and β-cell autophagy has increased substantially in recent years. In this review, we will discuss what is currently known regarding the role of β-cell autophagy in type 1 and type 2 diabetes pathogenesis, with an emphasis on new and exciting developments over the past 5 years. Further, we will discuss how these discoveries might be translated into unique treatments in the coming years.

A cost-effective traffic data collection system based on the iDEN mobile telecommunication network.

Science.gov (United States)

2008-10-01

This report describes a cost-effective data collection system for Caltrans 170 traffic signal : controller. The data collection system is based on TCP/IP communication over existing : low-cost mobile communication networks and Motorola iDEN1 mobile...

[Morphology and pathogenesis of visceral manifestations of chronic alcoholism].

Science.gov (United States)

Lebedev, S P

1982-01-01

Chronic alcoholism is accompanied by systemic involvement of the internal organs. Clinico-morphological forms of chronic alcoholism are distinguished on the basis of the prevailing organ pathology, Morphological data are presented, and pathogenesis of the lesions of the liver, heart, pancreas, and kidneys in patients with chronic alcoholism is analysed. The hepatic form may present alcoholic dystrophy, hepatitis or cirrhosis which are stages of progressing hepatopathy. The toxic and metabolic effect of ethanol is important in the pathogenesis of liver lesion. The cardiac form is characterized by the development of alcoholic myocardiodystrophy. In addition to the toxic influence of ethanol, hormonal and electrolyte changes and microcirculatory disorders play a role in its pathogenesis. Chronic calcifying pancreatitis in chronic alcoholism is associated with the effect of ethanol on the mediatory system. The renal form any present necronephrosis, hepatorenal syndrome, glomerulonephritis or pyelonephritis. Their pathogenesis is determined by toxicity of ethanol, circulation of immune complexes in the blood, or immunosuppression.

Kaposi sarcoma herpesvirus pathogenesis

Science.gov (United States)

Koch, Sandra; Schulz, Thomas F.

2017-01-01

Kaposi sarcoma herpesvirus (KSHV), taxonomical name human gammaherpesvirus 8, is a phylogenetically old human virus that co-evolved with human populations, but is now only common (seroprevalence greater than 10%) in sub-Saharan Africa, around the Mediterranean Sea, parts of South America and in a few ethnic communities. KSHV causes three human malignancies, Kaposi sarcoma, primary effusion lymphoma, and many cases of the plasmablastic form of multicentric Castleman's disease (MCD) as well as occasional cases of plasmablastic lymphoma arising from MCD; it has also been linked to rare cases of bone marrow failure and hepatitis. As it has colonized humans physiologically for many thousand years, cofactors are needed to allow it to unfold its pathogenic potential. In most cases, these include immune defects of genetic, iatrogenic or infectious origin, and inflammation appears to play an important role in disease development. Our much improved understanding of its life cycle and its role in pathogenesis should now allow us to develop new therapeutic strategies directed against key viral proteins or intracellular pathways that are crucial for virus replication or persistence. Likewise, its limited (for a herpesvirus) distribution and transmission should offer an opportunity for the development and use of a vaccine to prevent transmission. This article is part of the themed issue ‘Human oncogenic viruses’. PMID:28893942

[Ulrike Plath. Esten und Deutsche in den baltischen Provinzen Russlands. Fremdheitskonstruktionen, Lebenswelten, Kolonialphantasien 1750-1850] / Lea Leppik

Index Scriptorium Estoniae

Leppik, Lea, 1962-

2014-01-01

Arvustus: Plath, Ulrike. Esten und Deutsche in den baltischen Provinzen Russlands. Fremdheitskonstruktionen, Lebenswelten, Kolonialphantasien 1750-1850 (Veröffentlichungen des Nordost-Institut, 11). Harrasowitz. Wiesbaden 2011.

Huangqin-Tang and Ingredients in Modulating the Pathogenesis of Ulcerative Colitis.

Science.gov (United States)

Wang, Chunyan; Tang, Xudong; Zhang, Li

2017-01-01

Ulcerative colitis (UC) is the most common inflammatory bowel disease worldwide. Current therapies in UC cause limitations, and herb medicine provides an important choice for UC treatment. Huangqin-Tang (HQT) is a well-known classical traditional Chinese herbal formula and has been used in China for thousands of years. A large number of pharmacological studies demonstrated HQT and its ingredients to be effective in treating UC. Though the therapeutic effect has been evaluated, comprehensive up-to-date reviews in this field are not yet available. Here we aim to review our current understanding of HQT and its ingredients in treating UC and how the agents modulate the main pathogenesis of the disease, including the intestinal environment, immune imbalance, inflammatory pathways, and oxidative stress. The summary on this issue may provide better understanding of HQT and its ingredients in treating UC and possibly help in promoting its clinical application.

Den hvide side af det (etnisk) blandet Danmark: En udforskning af køns- og racerelaterede aspekter i blandede parforhold

DEFF Research Database (Denmark)

Singla, Rashmi

2017-01-01

af sådanne blandede par gennem stigninger i pardannelse på tværs af socialt konstruererede nationale og etniske/ race grænser. På trods af den hvide ægtefælles privilegeret position i samfundet (Twine, 2010) er deres motivation, hverdagsdynamikker, bevidsthed relateret til køns-udfordringer og...... mixed couple). Fokus er især på hvordan blandedhed (mixedness) kontekstualiseres i Danmark samt hvilke strategier der anvendes til at forhandle de køns- og racemæssige processer i det sociale rum. Derudover besværes spørgsmål som hvilke kategorier deres børn inkluderes i eller ekskluderes fra og hvilke...... race/ farve - én partner tilhører den hvide danske kategori, mens den anden stammer fra Sydasien (Indien eller Pakistan). Primært baseret på kvalitative interviews foretaget i Danmark (Singla, 2012, 2015) er begge køns erfaringer analyseret. Artiklen diskuterer også væsentlige metodiske...

Research advances in the pathogenesis of nonalcoholic fatty liver disease

Directory of Open Access Journals (Sweden)

WANG Hu

2017-04-01

Full Text Available Nonalcoholic fatty liver disease (NAFLD has been developing rapidly in recent years and has become one of the most common liver diseases. However, its pathogenesis remains unclear, and there are no widely accepted therapeutic regimens. NAFLD has a complex pathogenesis with multiple factors involved, including insulin resistance, oxidative stress, bile acid metabolic disorders, and autophagy. This article reviews the pathogenesis of NAFLD in order to provide a reference for further research and clinical treatment in the future.

Frieden durch Ineffizienz? Die Reform der US Cyberwar Strategie nach den Snowden-Leaks

OpenAIRE

Schmetz, Martin

2013-01-01

Es tut sich etwas in Folge der Snowden-Leaks: In den USA werden Untersuchungsausschüsse eingesetzt, Vorstöße, die Macht der NSA einzuschränken bzw.transparenter zu gestalten werden stärker – vor allem aber wird es wohl institutionelle Änderungen geben. Und diese hängen an einer Person: Keith Alexander.

Forskningsbibliotekerne får travlt, hvis den nationale Open Access strategi skal lykkes

DEFF Research Database (Denmark)

Ibanez, Karen Sofie Hytteballe; Sandfær, Anne

2014-01-01

Med nedsættelsen af en national styregruppe for Open Access (OA) ser der endelig ud til at ske noget på den front i Danmark. Uddannelses og Forskningsministeriet har, efter at have anbefalinger liggende i skuffen i flere år, nu endelig meldt en national strategi ud. Målet er 80% grøn OA i 2017 og...

Udbredelse af den invasive polychaete Marenzelleria spp. i danske farvande samt effekten på sedimentmiljøet

DEFF Research Database (Denmark)

Christoffersen, Kenn L; Banta, Gary Thomas

De europæiske arter af børsteormen Marenzelleria består af tre siblingearter (M. viridis, M. neglecta og M. arctia). De stammer oprindeligt fra den Nord Amerikanske østkyst og Arktis og har været i den sydlige Østersø siden de tidlige 1980’ere. De har stor tolerance over for svingende salinitet...... genetisk analyse efter metoden beskrevet i Blank et al. 2007 [1]. De genetiske metoder er baseret på PCR/RFLP og bruges i dette projekt til at bestemme udbredelsen af de tre sibling arter i danske farvande. Den quantitative fauna opgørelse, samt de forskellige sediment parametre, såsom organisk indhold og...... Sjælland mangler stadig, men forventes foretaget før mødet. På mødet præsenteres foreløbig data om Marenzellerias udbredelse og sedimentkarakteristika.. [1] Blank M., Laine A.O., Jürss K. and Bastrop R. 2007. Molecular identification key based on PCR/RFLP for three polychaete sibling species of the genus...

Bordetella pertussis pathogenesis: current and future challenges

Science.gov (United States)

Melvin, Jeffrey A.; Scheller, Erich V.; Miller, Jeff F.; Cotter, Peggy A.

2014-01-01

Pertussis, or whooping cough, has recently reemerged as a major public health threat despite high levels of vaccination against the etiological agent, Bordetella pertussis. In this Review, we describe the pathogenesis of this disease, with a focus on recent mechanistic insights into virulence factor function. We also discuss the changing epidemiology of pertussis and the challenges of vaccine development. Despite decades of research, many aspects of B. pertussis physiology and pathogenesis remain poorly understood. We highlight knowledge gaps that must be addressed to develop improved vaccines and therapeutic strategies. PMID:24608338

Groei van ongelijkjarige mengingen van grove den en berk op arme zandgronden; resultaten van metingen in 22 opstanden op de Veluwe en de Sallandse Heuvelrug

NARCIS (Netherlands)

Wijdeven, S.M.J.; Oosterbaan, A.; Berg, v.d. C.; Jole, van M.

2000-01-01

Het voorkomen en de groei van berk in ongelijkjarige mengingen van grove den en berk is bepaald op basis van opstandgemiddelden. Er is geen duidelijk verband tussen het voorkomen en de groei van berk en de schermdichtheid van grove den. Actuele groeigegevens zijn noodzakelijk voor een nadere

Signaling Pathways in Pathogenesis of Diamond Blackfan Anemia

Science.gov (United States)

2015-12-01

AWARD NUMBER: W81XWH-12-1-0590 TITLE: SIGNALING PATHWAYS IN PATHOGENESIS OF DIAMOND BLACKFAN ANEMIA PRINCIPAL INVESTIGATOR: KATHLEEN M...SUBTITLE 5a. CONTRACT NUMBER W81XWH-12-1-0590 SIGNALING PATHWAYS IN PATHOGENESIS OF DIAMOND BLACKFAN ANEMIA 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER...Unlimited 13. SUPPLEMENTARY NOTES None 14. ABSTRACT: Diamond Blackfan Anemia (DBA) is a disorder that results in pure red cell aplasia, congenital

Nyttan av franchising i den svenska fastighetsmäklarbranschen

OpenAIRE

Herke, Marie; Olivers, Marielle

2012-01-01

Franchising är det mest vanliga kedjekonceptet i fastighetsmäklarbranschen och flera av de största fastighetsmäklarkedjorna är franchisekedjor. De fristående mäklarbyråerna får allt svårare att klara sig i den ökade konkurrensen. Det är främst fristående mäklarbyråer på mindre orter med ett etablerat varumärke samt nischade mäklarbyråer som klarar sig i konkurrensen med de stora kedjorna. På senare år har antalet kedjeanslutna fastighetsmäklare ökat betydligt och flertalet av mäklarkedjorna ä...

Transposon mutagenesis reveals differential pathogenesis of Ralstonia solanacearum on tomato and Arabidopsis.

Science.gov (United States)

Lin, Yu-Mei; Chou, I-Chun; Wang, Jaw-Fen; Ho, Fang-I; Chu, Yu-Ju; Huang, Pei-Cheng; Lu, Der-Kang; Shen, Hwei-Ling; Elbaz, Mounira; Huang, Shu-Mei; Cheng, Chiu-Ping

2008-09-01

Ralstonia solanacearum causes a deadly wilting disease on a wide range of crops. To elucidate pathogenesis of this bacterium in different host plants, we set out to identify R. solanacearum genes involved in pathogenesis by screening random transposon insertion mutants of a highly virulent strain, Pss190, on tomato and Arabidopsis thaliana. Mutants exhibiting various decreased virulence levels on these two hosts were identified. Sequence analysis showed that most, but not all, of the identified pathogenesis genes are conserved among distinct R. solanacearum strains. A few of the disrupted loci were not reported previously as being involved in R. solanacearum pathogenesis. Notably, a group of mutants exhibited differential pathogenesis on tomato and Arabidopsis. These results were confirmed by characterizing allelic mutants in one other R. solanacearum strain of the same phylotype. The significantly decreased mutants' colonization in Arabidopsis was found to be correlated with differential pathogenesis on these two plants. Differential requirement of virulence genes suggests adaptation of this bacterium in different host environments. Together, this study reveals commonalities and differences of R. solanacearum pathogenesis on single solanaceous and nonsolanaceous hosts, and provides important new insights into interactions between R. solanacearum and different host plants.

Advances in the microbial etiology and pathogenesis of early childhood caries

Science.gov (United States)

Hajishengallis, Evlambia; Parsaei, Yassmin; Klein, Marlise I.; Koo, Hyun

2016-01-01

Early childhood caries (ECC) is one of the most prevalent infectious diseases affecting children worldwide. ECC is an aggressive form of dental caries, which left untreated, can result in rapid and extensive cavitation in teeth (rampant caries) that is painful and costly to treat. Furthermore, it affects mostly children from impoverished background, and thus constitutes a major challenge in public health. The disease is a prime example of the consequences arising from complex, dynamic interactions between microorganisms, host and diet, leading to the establishment of highly pathogenic (cariogenic) biofilms. To date, there are no effective methods to identify those at risk of developing ECC or control the disease in affected children. Recent advances in deep-sequencing technologies, novel imaging methods and (meta)proteomics-metabolomics approaches provide an unparalleled potential to reveal new insights to illuminate our current understanding about the etiology and pathogenesis of the disease. In this concise review, we provide a broader perspective about the etiology and pathogenesis of ECC based on previous and current knowledge on biofilm matrix, microbial diversity and host-microbe interactions which could have direct implications for developing new approaches for improved risk assessment and prevention of this devastating and costly childhood health condition. PMID:26714612

Pathogenesis of Lafora Disease: Transition of Soluble Glycogen to Insoluble Polyglucosan.

Science.gov (United States)

Sullivan, Mitchell A; Nitschke, Silvia; Steup, Martin; Minassian, Berge A; Nitschke, Felix

2017-08-11

Lafora disease (LD, OMIM #254780) is a rare, recessively inherited neurodegenerative disease with adolescent onset, resulting in progressive myoclonus epilepsy which is fatal usually within ten years of symptom onset. The disease is caused by loss-of-function mutations in either of the two genes EPM2A (laforin) or EPM2B (malin). It characteristically involves the accumulation of insoluble glycogen-derived particles, named Lafora bodies (LBs), which are considered neurotoxic and causative of the disease. The pathogenesis of LD is therefore centred on the question of how insoluble LBs emerge from soluble glycogen. Recent data clearly show that an abnormal glycogen chain length distribution, but neither hyperphosphorylation nor impairment of general autophagy, strictly correlates with glycogen accumulation and the presence of LBs. This review summarizes results obtained with patients, mouse models, and cell lines and consolidates apparent paradoxes in the LD literature. Based on the growing body of evidence, it proposes that LD is predominantly caused by an impairment in chain-length regulation affecting only a small proportion of the cellular glycogen. A better grasp of LD pathogenesis will further develop our understanding of glycogen metabolism and structure. It will also facilitate the development of clinical interventions that appropriately target the underlying cause of LD.

Diabetic Cataract—Pathogenesis, Epidemiology and Treatment

Directory of Open Access Journals (Sweden)

Andreas Pollreisz

2010-01-01

This paper provides an overview of the pathogenesis of diabetic cataract, clinical studies investigating the association between diabetes and cataract development, and current treatment of cataract in diabetics.

Nutritional rickets: pathogenesis and prevention.

Science.gov (United States)

Pettifor, John M

2013-06-01

Nutritional rickets remains a public health concern in many areas of the world despite cheap and effective means of preventing the disease. The roles of vitamin D deficiency, low dietary calcium intakes and the interrelationships between the two in the pathogenesis of the disease are discussed. It is now recognized that vitamin D deficiency in the pregnant and lactating mother predisposes to the development of rickets in the breastfed infant, and that cultural and social factors are important in the pathogenesis of the disease during the adolescent growth spurt. Prevention of rickets is dependent on the awareness of the medical profession and the general public of the need to ensure adequate intakes of vitamin D in at-risk populations, and of the importance of increasing dietary intakes of calcium using locally available and inexpensive foods in communities in which dietary calcium deficiency rickets is prevalent.

Understanding the impact of infection, inflammation and their persistence in the pathogenesis of bronchopulmonary dysplasia

Directory of Open Access Journals (Sweden)

Jherna eBalany

2015-12-01

Full Text Available The concerted interaction of genetic and environmental factors act on the preterm human immature lung with inflammation being the common denominator leading to the multifactorial origin of the most common chronic lung disease in infants – bronchopulmonary dysplasia or BPD. Adverse perinatal exposure to infection/inflammation with added insults like invasive mechanical ventilation, exposure to hyperoxia and sepsis causes persistent immune dysregulation. In this review article we have attempted to analyze and consolidate current knowledge about the role played by persistent prenatal and postnatal inflammation in the pathogenesis of BPD. While some parameters of the early inflammatory response (neutrophils, cytokines etc. may not be detectable after days to weeks of exposure to noxious stimuli, they have already initiated the signaling pathways of the inflammatory process / immune cascade and have affected permanent defects structurally and functionally in the BPD lungs. Hence translational research aimed at prevention / amelioration of BPD needs to focus on dampening the inflammatory response at an early stage to prevent the cascade of events leading to lung injury with impaired healing resulting in the pathologic pulmonary phenotype of alveolar simplification and dysregulated vascularization characteristic of BPD.

Fælles og gensidige testamenter efter den ny arvelov - med fokus på længstlevende testators testations- og rådighedsbeføjelser

DEFF Research Database (Denmark)

Feldthusen, Rasmus Kristian

2008-01-01

Ved arveloven indførtes bl.a. nye regler for fælles testamenter, hvilke i væsentlig omfang afviger fra reglerne i den nu ophævede arvelov. I artiklen analyseres føromtalte regler, der er placeret i arvelovens kap. 13, idet den nye definition »fælles testamente«, kritiseres for ikke at indeholde...

On the pathogenesis of IDDM

DEFF Research Database (Denmark)

Nerup, J; Mandrup-Poulsen, Thomas; Helqvist, S

1994-01-01

A model of the pathogenesis of insulin-dependent diabetes mellitus, i.e. the initial phase of beta-cell destruction, is proposed: in a cascade-like fashion efficient antigen presentation, unbalanced cytokine, secretion and poor beta-cell defence result in beta-cell destruction by toxic free...

DIE ERFORSCHUNG DER VEGETATIONSDYNAMIK IN DEN NORDWESTEN DES BANATS (KREIS TEMESCH, RUMÄNIEN

Directory of Open Access Journals (Sweden)

M. Fizitea

2004-01-01

Full Text Available Die Evolution und Aufeinanderfolge der Vegetationsvereine erfolgte in enger Verbindung mit den pädoklimatischen und zooantropischen Faktoren. Die Periode der antropogenen Vegetation wird charakterisiert durch die Vorherrschaft der gezüchteten Arten, welche zur Verbreitung der Agrophytozönosen sowie der ruderolen und segetalen Vegetation führte und somit die vorherigen Phytozönosen ersetzt.

Advances in bovine tuberculosis diagnosis and pathogenesis: what policy makers need to know.

Science.gov (United States)

Palmer, Mitchell V; Waters, W Ray

2006-02-25

The mainstay of tuberculosis diagnosis in cattle and deer has been the tuberculin skin test. Recent advances have allowed the incorporation of blood based assays to the diagnostic arsenal for both cattle and deer. Use of defined and specific antigens has allowed for improved specificity of cell mediated assays in both cattle and deer and advances in antibody tests for tuberculosis have potential for use in free-ranging and captive cervid populations. Combined use of blood-based assays with skin testing will require further understanding of the effect of skin testing on the accuracy of blood based assays. Models of experimental infection of cattle have allowed for increased understanding of natural disease pathogenesis. Differences likely exist; however, between cattle and deer in both disease distribution and primary route of inoculation in naturally infected animals.

Elucidating the Pathogenesis of Pre-eclampsia Using In Vitro Models of Spiral Uterine Artery Remodelling.

Science.gov (United States)

McNally, Ross; Alqudah, Abdelrahim; Obradovic, Danilo; McClements, Lana

2017-10-23

The aim of the study is to perform a critical assessment of in vitro models of pre-eclampsia using complementary human and cell line-based studies. Molecular mechanisms involved in spiral uterine artery (SUA) remodelling and trophoblast functionality will also be discussed. A number of proteins and microRNAs have been implicated as key in SUA remodelling, which could be explored as early biomarkers or therapeutic targets for prevention of pre-eclampsia. Various 2D and 3D in vitro models involving trophoblast cells, endothelial cells, immune cells and placental tissue were discussed to elucidate the pathogenesis of pre-eclampsia. Nevertheless, pre-eclampsia is a multifactorial disease, and the mechanisms involved in its pathogenesis are complex and still largely unknown. Further studies are required to provide better understanding of the key processes leading to inappropriate placental development which is the root cause of pre-eclampsia. This new knowledge could identify novel biomarkers and treatment strategies.

The complement system: a gateway to gene-environment interactions in schizophrenia pathogenesis.

Science.gov (United States)

Nimgaonkar, V L; Prasad, K M; Chowdari, K V; Severance, E G; Yolken, R H

2017-11-01

The pathogenesis of schizophrenia is considered to be multi-factorial, with likely gene-environment interactions (GEI). Genetic and environmental risk factors are being identified with increasing frequency, yet their very number vastly increases the scope of possible GEI, making it difficult to identify them with certainty. Accumulating evidence suggests a dysregulated complement pathway among the pathogenic processes of schizophrenia. The complement pathway mediates innate and acquired immunity, and its activation drives the removal of damaged cells, autoantigens and environmentally derived antigens. Abnormalities in complement functions occur in many infectious and autoimmune disorders that have been linked to schizophrenia. Many older reports indicate altered serum complement activity in schizophrenia, though the data are inconclusive. Compellingly, recent genome-wide association studies suggest repeat polymorphisms incorporating the complement 4A (C4A) and 4B (C4B) genes as risk factors for schizophrenia. The C4A/C4B genetic associations have re-ignited interest not only in inflammation-related models for schizophrenia pathogenesis, but also in neurodevelopmental theories, because rodent models indicate a role for complement proteins in synaptic pruning and neurodevelopment. Thus, the complement system could be used as one of the 'staging posts' for a variety of focused studies of schizophrenia pathogenesis. They include GEI studies of the C4A/C4B repeat polymorphisms in relation to inflammation-related or infectious processes, animal model studies and tests of hypotheses linked to autoimmune diseases that can co-segregate with schizophrenia. If they can be replicated, such studies would vastly improve our understanding of pathogenic processes in schizophrenia through GEI analyses and open new avenues for therapy.

DensToolKit: A comprehensive open-source package for analyzing the electron density and its derivative scalar and vector fields

Science.gov (United States)

Solano-Altamirano, J. M.; Hernández-Pérez, Julio M.

2015-11-01

DensToolKit is a suite of cross-platform, optionally parallelized, programs for analyzing the molecular electron density (ρ) and several fields derived from it. Scalar and vector fields, such as the gradient of the electron density (∇ρ), electron localization function (ELF) and its gradient, localized orbital locator (LOL), region of slow electrons (RoSE), reduced density gradient, localized electrons detector (LED), information entropy, molecular electrostatic potential, kinetic energy densities K and G, among others, can be evaluated on zero, one, two, and three dimensional grids. The suite includes a program for searching critical points and bond paths of the electron density, under the framework of Quantum Theory of Atoms in Molecules. DensToolKit also evaluates the momentum space electron density on spatial grids, and the reduced density matrix of order one along lines joining two arbitrary atoms of a molecule. The source code is distributed under the GNU-GPLv3 license, and we release the code with the intent of establishing an open-source collaborative project. The style of DensToolKit's code follows some of the guidelines of an object-oriented program. This allows us to supply the user with a simple manner for easily implement new scalar or vector fields, provided they are derived from any of the fields already implemented in the code. In this paper, we present some of the most salient features of the programs contained in the suite, some examples of how to run them, and the mathematical definitions of the implemented fields along with hints of how we optimized their evaluation. We benchmarked our suite against both a freely-available program and a commercial package. Speed-ups of ˜2×, and up to 12× were obtained using a non-parallel compilation of DensToolKit for the evaluation of fields. DensToolKit takes similar times for finding critical points, compared to a commercial package. Finally, we present some perspectives for the future development and

Den filosofiske krimi. Med særligt fokus på Henning Mortensens Sondrup-trilogi

DEFF Research Database (Denmark)

Hansen, Kim Toft

2008-01-01

Når man starter en roman med et citat af filosoffen Ludwig Wittgenstein, er tonen allerede slået an. Lader man dernæst en mand finde dolket, bliver det hurtigt tydeligt, hvor vi befinder os: kriminalromanens sprossede skygge. Men hos den danske forfatter Henning Mortensen falder skyggerne på en...

”Den lange rejse …” – metaforiske betydningslag i filmmediet En analyse af Aarhus Universitets vejlednings-, branding- og rekrutteringskampagne 2012

Directory of Open Access Journals (Sweden)

Christine Petersen

2014-11-01

Full Text Available Artiklen tager udgangspunkt i kampagnefilmen ”Tænk. Hvis det er dig”, som var en del af den branding-, vejlednings- og rekrutteringskampagne, som Aarhus Universitet lancerede i 2012, og på baggrund af en analyse af filmens komposition samt billed- og lydside undersøger artiklen, hvordan kampagnefilmen opbygger en handlingsmæssig struktur, som realiserer en grundlæggende metaforisk forståelse af ’uddannelse som en rejse’. Ved hjælp af George Lakoff og Mark Johnsons metaforteori undersøges den anvendte metafors beskaffenhed, struktur og betydning(er, og i artiklen argumenterer vi for en tolkning af den anvendte metafor som ’uddannelse som en moderne dannelsesrejse’. Lakoff og Johnsons metaforteori, som tager udgangspunkt i sproglige tegn, vil i denne artikel blive anvendt på analysen af visuelle tegn, og dermed ønsker vi at demonstrere, at et oprindeligt sproglig-tekstuelt baseret metaforbegreb også kan bidrage til en bedre forst.else af visuel-fi lmiske narrative teknikker.

Modes of thermal protection in polar bear cubs--at birth and on emergence from the den.

Science.gov (United States)

Blix, A S; Lentfer, J W

1979-01-01

At birth in late December the polar bear is small (700 g), uninsulated, and helpless. It probably has a modest capacity for metabolic heat production and depends on the female and a snow den in which it is born for thermal protection. The microclimate of an artificial polar bear den was investigated at Point Barrow, AK, and the temperature therein found to stay around 0 degrees C provided a heat source (200 W) equivalent to an adult polar bear was introduced. When the bears desert the den in early April the cub has grown to about 10 kg and has a well-developed fur insulation, but almost no subcutaneous fat. The cub has a high resting metabolic rate (4.6 W.kg-1), which is supported by the fat polar bear milk. Its lower critical temperature is about -30 degrees C, and an ambient temperature of -45 degrees C results in only a 33% increase in metabolism. The cub can tolerate a wind chill of 2.3 kW.m2 without apparent stress of drop in rectal temperature. If the cub is immersed in ice water rectal temperature drops 11 degrees C in 30 min. It is concluded that the cub can tolerate extremely low temperatures in air due to fur insulation and high metabolic heat production, but is unable to cope with the chill of ice water for any prolonged period of time.

Role of the Lung Microbiome in the Pathogenesis of Chronic Obstructive Pulmonary Disease.

Science.gov (United States)

Wang, Lei; Hao, Ke; Yang, Ting; Wang, Chen

2017-09-05

The development of culture-independent techniques for microbiological analysis shows that bronchial tree is not sterile in either healthy or chronic obstructive pulmonary disease (COPD) individuals. With the advance of sequencing technologies, lung microbiome has become a new frontier for pulmonary disease research, and such advance has led to better understanding of the lung microbiome in COPD. This review aimed to summarize the recent advances in lung microbiome, its relationships with COPD, and the possible mechanisms that microbiome contributed to COPD pathogenesis. Literature search was conducted using PubMed to collect all available studies concerning lung microbiome in COPD. The search terms were "microbiome" and "chronic obstructive pulmonary disease", or "microbiome" and "lung/pulmonary". The papers in English about lung microbiome or lung microbiome in COPD were selected, and the type of articles was not limited. The lung is a complex microbial ecosystem; the microbiome in lung is a collection of viable and nonviable microbiota (bacteria, viruses, and fungi) residing in the bronchial tree and parenchymal tissues, which is important for health. The following types of respiratory samples are often used to detect the lung microbiome: sputum, bronchial aspirate, bronchoalveolar lavage, and bronchial mucosa. Disordered bacterial microbiome is participated in pathogenesis of COPD; there are also dynamic changes in microbiota during COPD exacerbations. Lung microbiome may contribute to the pathogenesis of COPD by manipulating inflammatory and/or immune process. Normal lung microbiome could be useful for prophylactic or therapeutic management in COPD, and the changes of lung microbiome could also serve as biomarkers for the evaluation of COPD.

DenInv3D: a geophysical software for three-dimensional density inversion of gravity field data

Science.gov (United States)

Tian, Yu; Ke, Xiaoping; Wang, Yong

2018-04-01

This paper presents a three-dimensional density inversion software called DenInv3D that operates on gravity and gravity gradient data. The software performs inversion modelling, kernel function calculation, and inversion calculations using the improved preconditioned conjugate gradient (PCG) algorithm. In the PCG algorithm, due to the uncertainty of empirical parameters, such as the Lagrange multiplier, we use the inflection point of the L-curve as the regularisation parameter. The software can construct unequally spaced grids and perform inversions using such grids, which enables changing the resolution of the inversion results at different depths. Through inversion of airborne gradiometry data on the Australian Kauring test site, we discovered that anomalous blocks of different sizes are present within the study area in addition to the central anomalies. The software of DenInv3D can be downloaded from http://159.226.162.30.

Management of Oehler’s Type III Dens Invaginatus Using Cone Beam Computed Tomography

Directory of Open Access Journals (Sweden)

Jaya Ranganathan

2016-01-01

Full Text Available Dens Invaginatus is a dental malformation that poses diagnostic difficulties in the clinical context. This anomaly may increase the risk of pulp disease and can potentially complicate endodontic procedure due to the aberrant root canal anatomy. Compared to conventional radiographs, three-dimensional images obtained with Cone Beam Computed Tomography (CBCT are invaluable in the diagnosis of the extent of this anomaly and in the appropriate treatment planning. Oehler’s classification (1957 for Dens Invaginatus (DI into three types depending on the depth of the invagination has been used for treatment planning. Of the three types Type III DI is characterized by infolding of the enamel into the tooth up to the root apex and is considered as the most severe variant of DI and hence the most challenging to treat endodontically, due to the morphological complexities. This report describes a case of Oehler’s Type III DI in a necrotic permanent maxillary lateral incisor in which CBCT images played a key role in diagnosis and treatment planning. The case was managed successfully by a combination of nonsurgical and surgical endodontic therapy with orthograde and retrograde thermoplastic gutta percha obturation.

Steppe lion remains imported by Ice Age spotted hyenas into the Late Pleistocene Perick Caves hyena den in northern Germany

Science.gov (United States)

Diedrich, Cajus G.

2009-05-01

Upper Pleistocene remains of the Ice Age steppe lion Panthera leo spelaea (Goldfuss, 1810) have been found in the Perick Caves, Sauerland Karst, NW Germany. Bones from many hyenas and their imported prey dating from the Lower to Middle Weichselian have also been recovered from the Perick Cave hyena den. These are commonly cracked or exhibit deep chew marks. The absence of lion cub bones, in contrast to hyena and cave bear cub remains in the Perick Caves, and other caves of northern Germany, excludes the possibility that P. leo spelaea used the cave for raising cubs. Only in the Wilhelms Cave was a single skeleton of a cub found in a hyena den. Evidence of the chewing, nibbling and cracking of lion bones and crania must have resulted from the importation and destruction of lion carcasses (4% of the prey fauna). Similar evidence was preserved at other hyena den caves and open air sites in Germany. The bone material from the Perick and other Central European caves points to antagonistic hyena and lion conflicts, similar to clashes of their modern African relatives.

Tussen de mazen van het net : drie Poolse mannen in Den Haag aan het woord

NARCIS (Netherlands)

Karijn Nijhoff

In deze publicatie staan de verhalen van drie Poolse mannen in Den Haag centraal. De onderzoeker, Karijn Nijhoff, heeft zeer intensief deze mannen gevolgd en hun verhalen opgetekend. We lezen over aankomst, vertrek en terugkomst. We zien een grillig proces van werken en niet werken, klussen en

Umweltbildung - Bildung für nachhaltige Entwicklung. Was macht den Unterschied?

OpenAIRE

Rost, Jürgen

2002-01-01

Der vorliegende Beitrag will zeigen, dass Bildung für eine nachhaltige Entwicklung gegenüber herkömmlicher Umweltbildung tatsächlich eine neue Qualität hat. ... Das Konzept der Bildung für eine nachhaltige Entwicklung hat eine weitere Facette neben der Umweltbildung, nämlich das Konzept des globalen Lernens. Zunächst werden die zentralen Probleme dargestellt, die die Umwelterziehung in den vergangenen drei Jahrzehnten nicht lösen konnte und woran sie vielleicht gescheitert ist. Abschnitt 2 be...

Opetuskäyttöön tarkoitetun robottikäden mallintaminen

OpenAIRE

Helminen, Vesa

2015-01-01

Insinöörityön tavoitteena oli tuottaa raportti opetuskäyttöön tarkoitetun robottikäden mallin-tamisprosessista. Työssä suunniteltiin, mallinnettiin ja valmistettiin ihmiskättä muistuttava kiertyvänivelinen robotti 3D-tulostamalla. Työn toimeksiantajana oli Metropolia Ammattikorkeakoulun sovelletun elektroniikan tutkimus- ja kehitysyksikkö Electria. Suunnittelussa määriteltiin robottikädelle tarvittavia ominaisuuksia, kuten koko, edullisuus ja nivelten lukumäärä. Päätavoitteena oli pitää r...

Role of Fat-Soluble Vitamins A and D in the Pathogenesis of Influenza: A New Perspective

OpenAIRE

Mawson, Anthony R.

2013-01-01

Reduced exposure to solar radiation, leading to a deficiency of vitamin D and hence impaired innate immunity, has been suggested as a trigger for influenza viral replication and as an explanation of seasonal influenza. Although this hypothesis accounts for many unexplained facts about the epidemiology of influenza, gaps remain in understanding the pathogenesis and manifestations of the disease. Several observations suggest a role for vitamin A compounds (retinoids) in the disease. This paper ...

Dansk udenrigs- og sikkerhedspolitisk aktivisme i en stadig mere multipolær verdensorden. Danmarks håndtering af den nye stormagt Kina

DEFF Research Database (Denmark)

Sørensen, Camilla T. N.

2016-01-01

Dansk udenrigs- og sikkerhedspolitik med dets fokus på at fremme dansk sikkerhed, danske interesser og danske værdier står over for nye betingelser. Det centrale spørgsmål er, hvordan dansk udenrigs- og sikkerhedspolitisk aktivisme skal operere i en stadig mere multipolær verdensorden. I artiklen...... anvendes en neoklassisk realistisk analyseramme, som muliggør analyse af, hvordan igangværende udviklinger i systemiske og indenrigspolitiske betingelser påvirker dansk udenrigs- og sikkerhedspolitik. Analysen viser, hvordan handlerummet for den danske værdipolitiske udenrigs- og sikkerhedspolitiske...... afhænger af stærke og stabile relationer til nye økonomiske og politiske magtcentre, som ikke deler værdier med Danmark. Den ændrede linje i dansk udenrigs- og sikkerhedspolitisk aktivisme viser sig tydeligst i forhold til Danmarks håndtering af den nye stormagt Kina, hvor 1990ernes danske megafondiplomati...

Comparative pathogenesis of rabies in bats and carnivores, and implications for spillover to humans.

Science.gov (United States)

Begeman, Lineke; GeurtsvanKessel, Corine; Finke, Stefan; Freuling, Conrad M; Koopmans, Marion; Müller, Thomas; Ruigrok, Tom J H; Kuiken, Thijs

2018-04-01

Bat-acquired rabies is becoming increasingly common, and its diagnosis could be missed partly because its clinical presentation differs from that of dog-acquired rabies. We reviewed the scientific literature to compare the pathogenesis of rabies in bats and carnivores-including dogs-and related this pathogenesis to differences in the clinical presentation of bat-acquired and dog-acquired rabies in human beings. For bat-acquired rabies, we found that the histological site of exposure is usually limited to the skin, the anatomical site of exposure is more commonly the face, and the virus might be more adapted for entry via the skin than for dog-acquired rabies. These factors could help to explain several differences in clinical presentation between individuals with bat-acquired and those with dog-acquired rabies. A better understanding of these differences should improve the recording of a patient's history, enable drawing up of a more sophisticated list of clinical characteristics, and therefore obtain an earlier diagnosis of rabies after contact with a bat or carnivore that has rabies. Copyright © 2018 Elsevier Ltd. All rights reserved.

Genomics, transcriptomics and proteomics to elucidate the pathogenesis of rheumatoid arthritis.

Science.gov (United States)

Song, Xinqiang; Lin, Qingsong

2017-08-01

Rheumatoid arthritis is an autoimmune disease that affects several organs and tissues, predominantly the synovial joints. The pathogenesis of this disease is not completely understood, which maybe involved in the genomic variations, gene expression, protein translation and post-translational modifications. These system variations in genomics, transcriptomics and proteomics are dynamic in nature and their crosstalk is overwhelmingly complex, thus analyzing them separately may not be very informative. However, various '-omics' techniques developed in recent years have opened up new possibilities for clarifying disease pathways and thereby facilitating early diagnosis and specific therapies. This review examines how recent advances in the fields of genomics, transcriptomics and proteomics have contributed to our understanding of rheumatoid arthritis.

Wie "zukunftsreich" ist das neue Lehramtsstudium? Bestandsaufnahme zu Medienbildung und digitalen Kompetenzen in den Curriculaentwürfen der Sekundarstufe der PädagogInnenbildung_NEU

Directory of Open Access Journals (Sweden)

Klaus Himpsl-Gutermann

2015-12-01

Full Text Available Durch die PädagogInnenbildung_NEU eröffnet sich derzeit die Chance, österreichweit in vier Verbundregionen in Kooperation zwischen Universitäten und Pädagogischen Hochschulen die Lehramtsausbildung für alle Schulstufen und Schultypen zukunftsweisend zu reformieren. Zu den Ansprüchen an das neue Studium gehört auch, dass es künftige LehrerInnen an die Schulen entsendet, die neben ihrer fachlichen Expertise mit aktuellen gesellschaftlichen Herausforderungen und Entwicklungen adäquat umgehen können. Die rasant voranschreitende Technologisierung und Digitalisierung unserer Gesellschaft gehört zweifelsohne zu diesen Herausforderungen. Die E-Learning-Strategiegruppe der österreichischen Pädagogischen Hochschulen (PHELS hat deshalb die aktuell vorliegenden Curricula und Curriculaentwürfe der Sekundarstufe Allgemeinbildung in den vier Verbundregionen einer kritischen Analyse hinsichtlich Medienbildung und digitaler Kompetenzen unterzogen − mit einem ernüchternden bis verheerenden Ergebnis: Es scheint nicht nur die historische Chance vertan, Medienbildung systematisch in der LehrerInnenausbildung und damit in den Schulen zu verankern, sondern durch die fehlende informatische Grundbildung laufen künftige Generationen auch Gefahr, auf zunehmend digitalisierten Arbeitsmärkten den internationalen Anschluss zu verlieren.

Theories on the Pathogenesis of Endometriosis

Directory of Open Access Journals (Sweden)

Samer Sourial

2014-01-01

Full Text Available Endometriosis is a common, chronic inflammatory disease defined by the presence of extrauterine endometrial tissue. The aetiology of endometriosis is complex and multifactorial, where several not fully confirmed theories describe its pathogenesis. This review examines existing theories on the initiation and propagation of different types of endometriotic lesions, as well as critically appraises the myriad of biologically relevant evidence that support or oppose each of the proposed theories. The current literature suggests that stem cells, dysfunctional immune response, genetic predisposition, and aberrant peritoneal environment may all be involved in the establishment and propagation of endometriotic lesions. An orchestrated scientific and clinical effort is needed to consider all factors involved in the pathogenesis of this multifaceted disease and to propose novel therapeutic targets to reach effective treatments for this distressing condition.

Soziologische Wissenskulturen zwischen individualisierter Inspiration und prozeduraler Legitimation. Zur Entwicklung qualitativer und interpretativer Sozialforschung in der deutschen und französischen Soziologie seit den 1960er Jahren

Directory of Open Access Journals (Sweden)

Reiner Keller

2016-01-01

Full Text Available Wie wissen Soziologinnen und Soziologen, was sie wissen? Trotz der Internationalisierung der Soziologie bestehen nach wie vor starke sprachräumliche Unterschiede in der soziologischen Wissensproduktion, in eingesetzten Theorien, Methoden und Fragestellungen. Der nachfolgende Beitrag erläutert die Entwicklung und Ausprägung der Unterschiedlichkeit soziologischer Wissenskulturen im Hinblick auf den Einsatz qualitativer bzw. interpretativer Ansätze seit den 1960er Jahren in Deutschland und Frankreich. Er stützt sich auf ein von uns 2012-2014 geleitetes Forschungsprojekt und dessen empirische Grundlagen: Dokumentenanalysen und Interviews. Wissenskulturen werden als die Arten und Weisen der Produktion und Legitimation von (hier: soziologischem Wissen verstanden. Diesbezüglich lässt sich von der Erkenntnisproduktion als dem zentralen Handlungsproblem soziologischen Forschens sprechen. Während für die französischsprachige Soziologie diagnostisch von einer Lösung dieses Erkenntnisproblems durch die den Forschenden zugeschriebenen Kompetenzen und Inspirationen ausgegangen werden kann, schiebt sich im deutschsprachigen Raume eine prozedurale Legitimation durch Verfahren in den Vordergrund. Der Beitrag rekonstruiert exemplarisch die Ausgangssituation dieser Entwicklungen um die Wende zu den 1960er Jahren und bettet sie in die weitere Entfaltung der jeweiligen Soziologien ein. Er will damit zur gegenwärtigen Entwicklung einer reflexiven Soziologie beitragen. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1601145

A realidade da pesquisa no DEN/UFS

Directory of Open Access Journals (Sweden)

Delvair de Brito Alves

1998-12-01

Full Text Available Esta pesquisa trata do processo de pesquisar no Departamento de Enfermagem e Nutrição da Universidade Federal de Sergipe - DEN/UFS. Ela foi desenvolvida a partir de entrevistas semi estruturadas realizadas com as docentes. Dos materiais obtidos, apresentamos concepções das docentes sobre grupos, linhas e projetos de pesquisa; a produção científica docente e discente; dificuldades e possibilidades relativas à atividade de pesquisar; estratégias que esse Departamento vem utilizando para o desenvolvimento da pesquisa, para a capacitação docente e formação de pesquisadores, além da inserção de estudantes (de graduação e de pós graduação no "mundo científico". Ela conclui pela necessidade de aprofundamento dessa atividade e pela divulgação e aplicação dos seus resultados na prática de enfermagem.

Når mobilen tager magten - nærvær i den digitale tidsalter

DEFF Research Database (Denmark)

Fenger, Morten Munthe

at se ind i en skærm? "Når mobilen tager magten" beskriver, hvordan den digitale teknologi og sociale medier såsom Facebook, Instagram og Snapchat går direkte ind og udnytter menneskets instikter, og tilfredsstiller vores behov hurtigere end vores forstand og vilje kan følge med og sige fra. "Når...

Headache in a patient with crowned dens: report of a new case.

Science.gov (United States)

Viana, Michele; Sainaghi, Pier P; Stecco, Alessandro; Mortara, Franco; Sprenger, Till; Goadsby, Peter J

2014-01-01

Crowned dens syndrome (CDS) is a clinical-radiological entity characterized by acute attacks of neck pain with fever, rigidity, general signs of inflammation, and calcification of the periodontoid articular structures. Case report with 42 months follow-up. An 81-year-old man, who had never suffered from headache before July 2010, developed strictly left-sided headaches. The pain was restricted to the left side of the scalp and felt more intense in the frontal area. The intensity was moderate to high with a throbbing quality. The pain had an orthostatic component and was worsened by neck hyperextension and Valsalva maneuvers. Neurological and general examinations were normal, except for a reduced range of motion of the neck. He was prescribed indomethacin orally 25 mg t.i.d. and had a partial response. After a week, he was given a dosage of 50 mg t.i.d. with complete remission of the pain. Brain magnetic resonance imaging was normal, while an magnetic resonance imaging of the cervical spine showed a non-homogeneous mass behind the odontoid process of C2, narrowing the subarachnoid space in C1, stretching the posterior longitudinal ligament, and touching the left vertebral artery. A computed tomography scan showed calcification of the soft tissue around the odontoid process and a thickening of the left C2 root. After 4 months, the indomethacin dosage was reduced step-by-step. Indomethacin was discontinued in March 2012. Since then, the headache has not recurred. We here present the case of a patient with headache and radiological findings of crowned dens. However, the clinical presentation differed from previous CDS cases in the literature in that the pain was unilateral with frontal localization and throbbing quality, as well as an orthostatic component and lack of either fever or inflammatory signs. The differential diagnosis also includes a remitting form of hemicrania continua, presenting with an atypical presentation, with neuroimaging incidental finding of

Trennung der Eltern: Wie wird sie den Kindern vermittelt und welchen Einfluss haben Art und Inhalt der Mitteilung auf das Trennungserleben der Kinder?

OpenAIRE

Weber, Annhild; Karle, Michael; Klosinski, Gunther

2004-01-01

Anhand von 45 Sorgerechtsgutachten über 89 Kinder aus den Jahren 1996-1999 und 62 schriftlich beantworteten Katamnesebögen der entsprechenden Eltern wurde untersucht, wie die Eltern den Kindern von ihrer bevorstehenden Trennung berichteten und ob Art und Inhalt dieser Mitteilung Auswirkungen auf die Trennungsbewältigung der betroffenen Kinder hatten. Hierzu wurde ein Fragebogen zur Gutachtenauswertung und zur Katamnesenerhebung erstellt. Es zeigte sich, dass nur in 48,9 % der Famil...

Immunogenetics and genetic susceptibility in the pathogenesis of autoimmune hepatitis

Directory of Open Access Journals (Sweden)

Das Anup K

2014-11-01

Full Text Available vAutoimmune hepatitis is a progressive liver disease. Its pathogenesis is unclear, but needs a ‘trigger’ to initiate the disease in a genetically susceptible person. The susceptibility is partly related to MHCII class genes, and more so with human leukocyte antigen (HLA. Several mechanisms have been proposed which, however, cannot fully explain the immunologic findings in autoimmune hepatitis. The susceptibility to any autoimmune disease is determined by several factors where genetic and immunological alterations, along with, environmental factor are active. MHCII antigens as a marker for AIH, or a predictor of treatment response and prognosis has been investigated. Since MHCII antigens show significant ethnic heterogeneity, mutations in MHCII may merely act as only precursors of the surface markers of immune cells, which can be of significance, because the changes in HLA and MHC are missing in certain populations. One such marker is the CTLA-4 (CD152 gene mutation, reported in the phenotypes representing susceptibility to AIH. Other candidate genes of cytokines, TNF, TGF-beta1 etc, have also been investigated but with unvalidated results. Paediatric AIH show differences in genetic susceptibility. Genetic susceptibility or resistance to AIH may be associated with polypeptides in DRB1 with certain amino-acid sequences. Understanding which genes are implicated in genesis and/or disease progression will obviously help to identify key pathways in AIH and provide better insights into its pathogenesis. But studies to identify responsible genes are complex because of the complex trait of AIH.

Briefe aus dem Morgenland - Otto Friedrich von Richters Forschungsreise in den Jahren 1814-1816 / Vladimir Sazonov

Index Scriptorium Estoniae

Sazonov, Vladimir, 1979-

2013-01-01

Arvustus: Briefe aus dem Morgenland - Otto Friedrich von Richters Forschungsreise in den Jahren 1814-1816, hrsg. von Indrek Jürjo, Sergei Stadnikov, Hamburger Beiträge zur Geschichte des östlichen Europa, Bd. 20. Hamburg: Verlag Dr. Kovač 2013, 313 lk.

Role of Ureaplasma Respiratory Tract Colonization in BPD Pathogenesis: Current Concepts and Update

Science.gov (United States)

Viscardi, Rose Marie; Kallapur, Suhas G.

2015-01-01

SYNOPSIS Respiratory tract colonization with the genital mycoplasma species Ureaplasma parvum and U. urealyticum in preterm infants is a significant risk factor for BPD. Recent studies of the ureaplasmal genome, animal infection models, and human infants have provided a better understanding of specific virulence factors, pathogen-host interactions, and variability in genetic susceptibility that contribute to chronic infection, inflammation, and altered lung development. This review will provide an update on the current evidence supporting a causal role of Ureaplasma infection in BPD pathogenesis. The current status of antibiotic trials to prevent BPD in Ureaplasma-infected preterm infants is also reviewed. PMID:26593075

Helium cryosystem for the X-ray laser LCLS-II; Heliumkryosystem fuer den Roentgenlaser LCLS-II

Energy Technology Data Exchange (ETDEWEB)

Pflueckhahn, Dirk; Fauve, Eric; Heloin, Vincent; Ravindranath, Viswanath; Ross, Marc [SLAC National Accelerator Laboratory, Menlo Park, CA (United States)

2017-07-01

The Linac Coherent Light Source-II project represents the expansion of the LCLS free-electron laser, which has been successfully operated at the SLAC National Accelerator Laboratory since 2009. In collaboration with several national institutes, 37 cryomodules with superconducting accelerator cavities will be installed in a 700 m long section of the existing tunnel. The use of superconducting accelerator technology will enable particle energy of up to 4 GeV in CW (continuous wave) operation. Two identical cryogenic systems with an equivalent output of 18 kW each at 4.5 K are described below. The plants supply the linear accelerator with helium at several temperature levels. Superfluid helium II provides the cooling necessary to maintain superconductivity in the cavities. The operating temperature of the 1.3 GHz cavities has been set at 2 K. Two further helium circuits are used for shield cooling at approx. 35 K and cooling of heat loads at 5 K level. The purely dynamic compression of the cold helium vapour is a technical feature of the systems described here. In a five-stage chain of cold compressors of 32 mbar at the cavities, it is absolutely compressed to the suction pressure of the circulation compressors at approx. 1 bar. [German] Das Linac Coherent Light Source-II Projekt stellt die Erweiterung des seit 2009 erfolgreich betriebenen Freie- Elektronen-Lasers LCLS am SLAC National Accelerator Laboratory dar. In Kollaboration mit mehreren nationalen Instituten werden in einem 700 m langen Teilstueck des bereits bestehenden Tunnels 37 Kryomodule mit supraleitenden Beschleunigerkavitaeten installiert. Der Einsatz von supraleitender Beschleunigertechnologie wird eine Teilchenenergie von bis zu 4 GeV im CW (continous wave) Betrieb ermoeglichen. Zwei identische Kryoanlagen mit einer aequivalenten Leistung von je 18 kW bei 4,5 K werden im Folgenden beschrieben. Die Anlagen versorgen den Linearbeschleuniger mit Helium auf mehreren Temperaturniveaus. Superfluides Helium

The American Heart Association Scientific Statement on salt sensitivity of blood pressure: Prompting consideration of alternative conceptual frameworks for the pathogenesis of salt sensitivity?

Science.gov (United States)

Kurtz, Theodore W; DiCarlo, Stephen E; Pravenec, Michal; Morris, R Curtis

2017-11-01

: Recently, the American Heart Association (AHA) published a scientific statement on salt sensitivity of blood pressure which emphasized a decades old conceptual framework for the pathogenesis of this common disorder. Here we examine the extent to which the conceptual framework for salt sensitivity emphasized in the AHA Statement accommodates contemporary findings and views of the broader scientific community on the pathogenesis of salt sensitivity. In addition, we highlight alternative conceptual frameworks and important contemporary theories of salt sensitivity that are little discussed in the AHA Statement. We suggest that greater consideration of conceptual frameworks and theories for salt sensitivity beyond those emphasized in the AHA Statement may help to advance understanding of the pathogenesis of salt-induced increases in blood pressure and, in consequence, may lead to improved approaches to preventing and treating this common disorder.

Den inre och yttre självkänslans betydelse för tendensen att bruka self-handicapping

OpenAIRE

Ottosson, Olivia

2008-01-01

Självkänsla är något vi ständigt bär med oss och den inverkar på vårt agerande samt våra val i livet. Johnson (2003) delar in självkänslan i två delar den inre och yttre, vilka kan kombineras till fyra personligheter. Forskning har visat att självkänslan samvarierar med tendensen till att bruka self-handicapping. Self-handicapping innebär att människan skapar hinder för sig själv påhittade eller verkliga. Etthundrasju studenter fyllde i en enkät bestående av 58 påståenden, vilken mätte inre, ...