WorldWideScience

Sample records for understanding den pathogenesis

  1. Current understanding in pathogenesis of atopic dermatitis

    Directory of Open Access Journals (Sweden)

    Tess McPherson

    2016-01-01

    Full Text Available There have been advances in our understanding of the complex pathogenesis of atopic eczema over the past few decades. This article examines the multiple factors which are implicated in this process.

  2. Recent advances in understanding ichthyosis pathogenesis

    Science.gov (United States)

    Marukian, Nareh V.; Choate, Keith A.

    2016-01-01

    The ichthyoses, also known as disorders of keratinization (DOK), encompass a heterogeneous group of skin diseases linked by the common finding of abnormal barrier function, which initiates a default compensatory pathway of hyperproliferation, resulting in the characteristic clinical manifestation of localized and/or generalized scaling. Additional cutaneous findings frequently seen in ichthyoses include generalized xerosis, erythroderma, palmoplantar keratoderma, hypohydrosis, and recurrent infections. In 2009, the Ichthyosis Consensus Conference established a classification consensus for DOK based on pathophysiology, clinical manifestations, and mode of inheritance. This nomenclature system divides DOK into two main groups: nonsyndromic forms, with clinical findings limited to the skin, and syndromic forms, with involvement of additional organ systems. Advances in next-generation sequencing technology have allowed for more rapid and cost-effective genetic analysis, leading to the identification of novel, rare mutations that cause DOK, many of which represent phenotypic expansion. This review focuses on new findings in syndromic and nonsyndromic ichthyoses, with emphasis on novel genetic discoveries that provide insight into disease pathogenesis. PMID:27408699

  3. Understanding rare disease pathogenesis: a grand challenge for model organisms.

    Science.gov (United States)

    Hieter, Philip; Boycott, Kym M

    2014-10-01

    In this commentary, Philip Hieter and Kym Boycott discuss the importance of model organisms for understanding pathogenesis of rare human genetic diseases, and highlight the work of Brooks et al., "Dysfunction of 60S ribosomal protein L10 (RPL10) disrupts neurodevelopment and causes X-linked microcephaly in humans," published in this issue of GENETICS. Copyright © 2014 by the Genetics Society of America.

  4. Progress towards understanding the pathogenesis of dengue hemorrhagic fever.

    Science.gov (United States)

    Pang, Xiaojing; Zhang, Rudian; Cheng, Gong

    2017-02-01

    Dengue virus (DENV) is a mosquito-borne virus belonging to the Flaviviridae family. There are 4 serotypes of DENV that cause human disease through transmission by mosquito vectors. DENV infection results in a broad spectrum of clinical symptoms, ranging from mild fever to dengue hemorrhagic fever (DHF), the latter of which can progress to dengue shock syndrome (DSS) and death. Researchers have made unremitting efforts over the last half-century to understand DHF pathogenesis. DHF is probably caused by multiple factors, such as virus-specific antibodies, viral antigens and host immune responses. This review summarizes the current progress of studies on DHF pathogenesis, which may provide important information for achieving effective control of dengue in the future.

  5. Understanding Anaplasmataceae pathogenesis using ‘Omics’ approaches

    Directory of Open Access Journals (Sweden)

    Ludovic ePruneau

    2014-07-01

    Full Text Available This paper examines how Omics approaches improve our understanding of Anaplasmataceae pathogenesis, through a global and integrative strategy to identify genes and proteins involved in biochemical pathways key for pathogen-host-vector interactions.The Anaplasmataceae family comprises obligate intracellular bacteria mainly transmitted by arthropods. These bacteria are responsible for major human and animal endemic and emerging infectious diseases with important economic and public health impacts. In order to improve disease control strategies, it is essential to better understand their pathogenesis. Our work focused on four Anaplasmataceae, which cause important animal, human and zoonotic diseases: Anaplasma marginale, A. phagocytophilum, Ehrlichia chaffeensis and E. ruminantium. Wolbachia spp. an endosymbiont of arthropods was also included in this review as a model of a non-pathogenic Anaplasmataceae.A gap analysis on Omics approaches on Anaplasmataceae was performed, which highlighted a lack of studies on the genes and proteins involved in the infection of hosts and vectors. Furthermore, most of the studies have been done on the pathogen itself, mainly on infectious free-living forms and rarely on intracellular forms. In order to perform a transcriptomic analysis of the intracellular stage of development, researchers developed methods to enrich bacterial transcripts from infected cells. These methods are described in this paper. Bacterial genes encoding outer membrane proteins, post-translational modifications, eukaryotic repeated motif proteins, proteins involved in osmotic and oxidative stress and hypothetical proteins have been identified to play a key role in Anaplasmataceae pathogenesis. Further investigations on the function of these outer membrane proteins and hypothetical proteins will be essential to confirm their role in the pathogenesis. Our work underlines the need for further studies in this domain and on host and vector responses

  6. Pathogenic Leptospira: Advances in understanding the molecular pathogenesis and virulence

    Directory of Open Access Journals (Sweden)

    Ciamak Ghazaei

    2018-01-01

    Full Text Available Leptospirosis is a common zoonotic disease has emerged as a major public health problem, with developing countries bearing disproportionate burdens. Although the diverse range of clinical manifestations of the leptospirosis in humans is widely documented, the mechanisms through which the pathogen causes disease remain undetermined. In addition, leptospirosis is a much-neglected life-threatening disease although it is one of the most important zoonoses occurring in a diverse range of epidemiological distribution. Recent advances in molecular profiling of pathogenic species of the genus Leptospira have improved our understanding of the evolutionary factors that determine virulence and mechanisms that the bacteria employ to survive. However, a major impediment to the formulation of intervention strategies has been the limited understanding of the disease determinants. Consequently, the association of the biological mechanisms to the pathogenesis of Leptospira, as well as the functions of numerous essential virulence factors still remain implicit. This review examines recent advances in genetic screening technologies, the underlying microbiological processes, the virulence factors and associated molecular mechanisms driving pathogenesis of Leptospira species.

  7. Pathogenic Leptospira: Advances in understanding the molecular pathogenesis and virulence

    Science.gov (United States)

    Ghazaei, Ciamak

    2018-01-01

    Leptospirosis is a common zoonotic disease has emerged as a major public health problem, with developing countries bearing disproportionate burdens. Although the diverse range of clinical manifestations of the leptospirosis in humans is widely documented, the mechanisms through which the pathogen causes disease remain undetermined. In addition, leptospirosis is a much-neglected life-threatening disease although it is one of the most important zoonoses occurring in a diverse range of epidemiological distribution. Recent advances in molecular profiling of pathogenic species of the genus Leptospira have improved our understanding of the evolutionary factors that determine virulence and mechanisms that the bacteria employ to survive. However, a major impediment to the formulation of intervention strategies has been the limited understanding of the disease determinants. Consequently, the association of the biological mechanisms to the pathogenesis of Leptospira, as well as the functions of numerous essential virulence factors still remain implicit. This review examines recent advances in genetic screening technologies, the underlying microbiological processes, the virulence factors and associated molecular mechanisms driving pathogenesis of Leptospira species. PMID:29445617

  8. Understanding the Pathogenesis of Angelman Syndrome through Animal Models

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    Nihar Ranjan Jana

    2012-01-01

    Full Text Available Angelman syndrome (AS is a neurodevelopmental disorder characterized by severe mental retardation, lack of speech, ataxia, susceptibility to seizures, and unique behavioral features such as easily provoked smiling and laughter and autistic features. The disease is primarily caused by deletion or loss-of-function mutations of the maternally inherited UBE3A gene located within chromosome 15q11-q13. The UBE3A gene encodes a 100 kDa protein that functions as ubiquitin ligase and transcriptional coactivator. Emerging evidence now indicates that UBE3A plays a very important role in synaptic function and in regulation of activity-dependent synaptic plasticity. A number of animal models for AS have been generated to understand the disease pathogenesis. The most widely used model is the UBE3A-maternal-deficient mouse that recapitulates most of the essential features of AS including cognitive and motor abnormalities. This paper mainly discusses various animal models of AS and how these models provide fundamental insight into understanding the disease biology for potential therapeutic intervention.

  9. Understanding the Pathogenesis of Angelman Syndrome through Animal Models

    Science.gov (United States)

    Jana, Nihar Ranjan

    2012-01-01

    Angelman syndrome (AS) is a neurodevelopmental disorder characterized by severe mental retardation, lack of speech, ataxia, susceptibility to seizures, and unique behavioral features such as easily provoked smiling and laughter and autistic features. The disease is primarily caused by deletion or loss-of-function mutations of the maternally inherited UBE3A gene located within chromosome 15q11-q13. The UBE3A gene encodes a 100 kDa protein that functions as ubiquitin ligase and transcriptional coactivator. Emerging evidence now indicates that UBE3A plays a very important role in synaptic function and in regulation of activity-dependent synaptic plasticity. A number of animal models for AS have been generated to understand the disease pathogenesis. The most widely used model is the UBE3A-maternal-deficient mouse that recapitulates most of the essential features of AS including cognitive and motor abnormalities. This paper mainly discusses various animal models of AS and how these models provide fundamental insight into understanding the disease biology for potential therapeutic intervention. PMID:22830052

  10. Insights from the Den: How Hibernating Bears May Help Us Understand and Treat Human Disease.

    Science.gov (United States)

    Berg von Linde, Maria; Arevström, Lilith; Fröbert, Ole

    2015-10-01

    Hibernating brown bears (Ursus arctos) and black bears (Ursus americanus) spend half of the year in a physically inactive state inside their winter dens without food intake and defecating and no or little urination. Under similar extreme conditions, humans would suffer from loss of lean body mass, heart failure, thrombosis, azotemia, osteoporosis, and more. However, bears exit the den in the spring strong without organ injuries. Translational animal models are used in human medicine but traditional experimental animals have several shortcomings; thus, we believe that it is time to systematically explore new models. In this review paper, we describe physiological adaptations of hibernating bears and how similar adaptations in humans could theoretically alleviate medical conditions. The bear has solved most of the health challenges faced by humans, including heart and kidney disease, atherosclerosis and thrombosis, and muscle wasting and osteoporosis. Understanding and applying this library of information could lead to a number of major discoveries that could have implications for the understanding and treatment of human disease. © 2015 Wiley Periodicals, Inc.

  11. Pathogenesis of biliary atresia: defining biology to understand clinical phenotypes

    Science.gov (United States)

    Asai, Akihiro; Miethke, Alexander; Bezerra, Jorge A.

    2016-01-01

    Biliary atresia is a severe cholangiopathy of early infancy that destroys extrahepatic bile ducts and disrupts bile flow. With a poorly defined disease pathogenesis, treatment consists of the surgical removal of duct remnants followed by hepatoportoenterostomy. Although this approach can improve the short-term outcome, the liver disease progresses to end-stage cirrhosis in most children. Further improvement in outcome will require a greater understanding of the mechanisms of biliary injury and fibrosis. Here, we review progress in the field, which has been fuelled by collaborative studies in larger patient cohorts and the development of cell culture and animal model systems to directly test hypotheses. Advances include the identification of phenotypic subgroups and stages of disease based on clinical, pathological and molecular features. Stronger evidence exists for viruses, toxins and gene sequence variations in the aetiology of biliary atresia, triggering a proinflammatory response that injures the duct epithelium and produces a rapidly progressive cholangiopathy. The immune response also activates the expression of type 2 cytokines that promote epithelial cell proliferation and extracellular matrix production by nonparenchymal cells. These advances provide insight into phenotype variability and might be relevant to the design of personalized trials to block progression of liver disease. PMID:26008129

  12. Advances in understanding the pathogenesis of pneumococcal otitis media.

    NARCIS (Netherlands)

    Tonnaer, E.L.G.M.; Graamans, K.; Sanders, E.A.M.; Curfs, J.H.A.J.

    2006-01-01

    In this review, a state of the art on otitis media research is provided with emphasis on the role of Streptococcus pneumoniae in the pathogenesis of this disease. Articles have been selected by MEDLINE search supplemented with a manual crosscheck of bibliographies. Pathogenic mechanisms in middle

  13. Recent Progress in Understanding Coxsackievirus Replication, Dissemination, and Pathogenesis

    Science.gov (United States)

    Sin, Jon; Mangale, Vrushali; Thienphrapa, Wdee; Gottlieb, Roberta A.; Feuer, Ralph

    2015-01-01

    Coxsackieviruses (CVs) are relatively common viruses associated with a number of serious human diseases, including myocarditis and meningo-encephalitis. These viruses are considered cytolytic yet can persist for extended periods of time within certain host tissues requiring evasion from the host immune response and a greatly reduced rate of replication. A member of Picornaviridae family, CVs have been historically considered non-enveloped viruses – although recent evidence suggest that CV and other picornaviruses hijack host membranes and acquire an envelope. Acquisition of an envelope might provide distinct benefits to CV virions, such as resistance to neutralizing antibodies and efficient nonlytic viral spread. CV exhibits a unique tropism for progenitor cells in the host which may help to explain the susceptibility of the young host to infection and the establishment of chronic disease in adults. CVs have also been shown to exploit autophagy to maximize viral replication and assist in unconventional release from target cells. In this article, we review recent progress in clarifying virus replication and dissemination within the host cell, identifying determinants of tropism, and defining strategies utilized by the virus to evade the host immune response. Also, we will highlight unanswered questions and provide future perspectives regarding the potential mechanisms of CV pathogenesis. PMID:26142496

  14. Neonatal respiratory distress: recent progress in understanding pathogenesis and treatment outcomes

    OpenAIRE

    So Young Kim

    2010-01-01

    Transient tachypnea of the newborn (TTN), respiratory distress syndrome (RDS), and persistent pulmonary hypertension (PPHN) are the three most common disorders that cause respiratory distress after birth. An understanding of the pathophysiology of these disorders and the development of effective therapeutic strategies is required to control these conditions. Here, we review recent papers on the pathogenesis and treatment of neonatal respiratory disease.

  15. MHC restriction to T-cell autoaggression: an emerging understanding of IDDM pathogenesis.

    Science.gov (United States)

    Choudhuri, K; Vergani, D

    1998-12-01

    The Nobel prize-winning discovery of MHC restriction by Zinkernagel and Doherty has led to some of the most exciting advances in immunology over the past two decades. The ongoing progress in our conceptual understanding of the processes governing the immunology to infection, tolerance to self and consequently the immune dysregulation in autoimmunity have all assimilated the laws of restriction as a central tenet. The focus of much of this research has been the T-cell and its interactions. Refinement of the paradigm of MHC restriction at the molecular level has allowed a view of the pathogenesis of insulin-dependent diabetes mellitus (IDDM), a prototypic autoimmune disease, unprecedented in its detail. This article discusses the impact of MHC restriction on the central themes of immunology, and focuses on its utility as a framework in understanding the role of the T-cell in the pathogenesis of IDDM.

  16. Neonatal respiratory distress: recent progress in understanding pathogenesis and treatment outcomes

    Directory of Open Access Journals (Sweden)

    So Young Kim

    2010-01-01

    Full Text Available Transient tachypnea of the newborn (TTN, respiratory distress syndrome (RDS, and persistent pulmonary hypertension (PPHN are the three most common disorders that cause respiratory distress after birth. An understanding of the pathophysiology of these disorders and the development of effective therapeutic strategies is required to control these conditions. Here, we review recent papers on the pathogenesis and treatment of neonatal respiratory disease.

  17. Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis

    Directory of Open Access Journals (Sweden)

    Ju-Ryoung Kim

    2018-02-01

    Full Text Available Osteoarthritis (OA is the most prevalent joint disease in older people and is characterized by the progressive destruction of articular cartilage, synovial inflammation, changes in subchondral bone and peri-articular muscle, and pain. Because our understanding of the aetiopathogenesis of OA remains incomplete, we haven’t discovered a cure for OA yet. This review appraises novel therapeutics based on recent progress in our understanding of the molecular pathogenesis of OA, including pro-inflammatory and pro-catabolic mediators and the relevant signalling mechanisms. The changes in subchondral bone and peri-articular muscle accompanying cartilage damage are also reviewed.

  18. Proteome Analysis—A Novel Approach to Understand the Pathogenesis of Type 1 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Allan E. Karlsen

    2001-01-01

    Full Text Available Type 1 (insulin-dependent diabetes mellitus (T1DM is associated with a specific destruction of the insulin-producing beta-cells in the islets of Langerhans. Several factors, e.g. genetic, environmental and immunologial, may be involved in the etiology and pathogenesis of T1DM. Autoreactive Tand B-lymphocytes, together with macrophages infiltrate the islets during the pathogenesis, releasing a mixture of cytokines, demonstrated to be specifically toxic to the beta-cells within the islets. Our goal is to understand the molecular mechanisms responsible for the beta-cell specific toxicity enabling us to design novel intervention strategies in T1DM. The proteome approach allows us to get a detailed picture of the beta-cell proteins, which change expression level or are post-translationally modified in different in vitro and in vivo models of T1DM-associated beta-cell destruction. Combining the information obtained from this extended proteome approach, with that of genetic-, transcriptome- and candidategene approaches, we believe that it is possible to reach this goal.

  19. Genetic and genomic perspective to understand the molecular pathogenesis of keratoconus

    Science.gov (United States)

    Jeyabalan, Nallathambi; Shetty, Rohit; Ghosh, Anuprita; Anandula, Venkata Ramana; Ghosh, Arka Subhra; Kumaramanickavel, Govindasamy

    2013-01-01

    Keratoconus (KC; Mendelian Inheritance in Man (OMIM) 14830) is a bilateral, progressive corneal defect affecting all ethnic groups around the world. It is the leading cause of corneal transplantation. The age of onset is at puberty, and the disorder is progressive until the 3rd–4th decade of life when it usually arrests. It is one of the major ocular problems with significant social and economic impacts as the disease affects young generation. Although genetic and environmental factors are associated with KC, but the precise etiology is still elusive. Results from complex segregation analysis suggests that genetic abnormalities may play an essential role in the susceptibility to KC. Due to genetic heterogeneity, a recent study revealed 17 different genomic loci identified in KC families by linkage mapping in various populations. The focus of this review is to provide a concise update on the current knowledge of the genetic basis of KC and genomic approaches to understand the disease pathogenesis. PMID:23925319

  20. Genetic and genomic perspective to understand the molecular pathogenesis of keratoconus

    Directory of Open Access Journals (Sweden)

    Nallathambi Jeyabalan

    2013-01-01

    Full Text Available Keratoconus (KC; Mendelian Inheritance in Man (OMIM 14830 is a bilateral, progressive corneal defect affecting all ethnic groups around the world. It is the leading cause of corneal transplantation. The age of onset is at puberty, and the disorder is progressive until the 3 rd -4 th decade of life when it usually arrests. It is one of the major ocular problems with significant social and economic impacts as the disease affects young generation. Although genetic and environmental factors are associated with KC, but the precise etiology is still elusive. Results from complex segregation analysis suggests that genetic abnormalities may play an essential role in the susceptibility to KC. Due to genetic heterogeneity, a recent study revealed 17 different genomic loci identified in KC families by linkage mapping in various populations. The focus of this review is to provide a concise update on the current knowledge of the genetic basis of KC and genomic approaches to understand the disease pathogenesis.

  1. [Understanding and treatment strategy of the pathogenesis of periodontal disease based on chronic inflammation].

    Science.gov (United States)

    Murakami, Tomohiko

    2016-05-01

    Prolonged inflammation continuously promotes the infiltration of macrophages in the organization and chronically induces the production of pro-inflammatory cytokines such as TNF and IL-1. In periodontal tissues, these inflammatory cytokines enhance the differentiation and activity of osteoclasts, which cause destruction of the alveolar bone. Therefore, inhibition of inflammatory cytokine production leads to the prevention or treatment of periodontal disease. IL-1 is a pro-inflammatory cytokine that strongly enhances the bone-resorbing activity of osteoclasts. Elucidation of mechanisms for the production of IL-1 is critical for understanding the pathogenesis of periodontal disease. This paper reviews recent findings of the molecular mechanisms regulating IL-1 production and focuses on inflammasome.

  2. Understanding the genetic and molecular pathogenesis of Friedreich’s ataxia through animal and cellular models

    Science.gov (United States)

    Martelli, Alain; Napierala, Marek; Puccio, Hélène

    2012-01-01

    In 1996, a link was identified between Friedreich’s ataxia (FRDA), the most common inherited ataxia in men, and alterations in the gene encoding frataxin (FXN). Initial studies revealed that the disease is caused by a unique, most frequently biallelic, expansion of the GAA sequence in intron 1 of FXN. Since the identification of this link, there has been tremendous progress in understanding frataxin function and the mechanism of FRDA pathology, as well as in developing diagnostics and therapeutic approaches for the disease. These advances were the subject of the 4th International Friedreich’s Ataxia Conference held on 5th–7th May in the Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France. More than 200 scientists gathered from all over the world to present the results of research spanning all areas of investigation into FRDA (including clinical aspects, FRDA pathogenesis, genetics and epigenetics of the disease, development of new models of FRDA, and drug discovery). This review provides an update on the understanding of frataxin function, developments of animal and cellular models of the disease, and recent advances in trying to uncover potential molecules for therapy. PMID:22382366

  3. Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis.

    Science.gov (United States)

    Mateen, Somaiya; Zafar, Atif; Moin, Shagufta; Khan, Abdul Qayyum; Zubair, Swaleha

    2016-04-01

    Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease of unknown etiology. It is characterized by the presence of rheumatoid factor and anti-citrullinated peptide antibodies. Initial phase of RA involves the activation of both T and B cells. Cytokines have a crucial role in the pathophysiology of RA as pro-inflammatory cytokines such as TNFα, IL-1, IL-17 stimulates inflammation and degradation of bone and cartilage. There occurs an imbalance between the pro- and anti-inflammatory cytokine activities which leads to multisystem immune complications. There occurs a decline in the number of Treg cells which may also play an important role in pathophysiology of the disease. In RA patients, serum or plasma level of cytokines may indicate the severity of disease. Cytokine gene polymorphism could be used as markers of susceptibility and severity of RA. Anti-cytokine agents seem to emerge as potent drug molecules to treat RA. Many clinical trials are ongoing and several positive results have been obtained. There is a need to develop potential anti-cytokine agents that target numerous pathways involved in the pathogenesis of RA. This review article describes the effector functions of pro- and anti-inflammatory cytokines and the role of cytokine gene polymorphism in the pathogenesis of RA. Anti-cytokine agents that are currently available and those that are still in clinical trials have also been summarized. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii: a review

    Directory of Open Access Journals (Sweden)

    William J Sullivan Jr

    2009-03-01

    Full Text Available Parasite differentiation from proliferating tachyzoites into latent bradyzoites is central to pathogenesis and transmission of the intracellular protozoan pathogen Toxoplasma gondii. The presence of bradyzoite-containing cysts in human hosts and their subsequent rupture can cause life-threatening recrudescence of acute infection in the immunocompromised and cyst formation in other animals contributes to zoonotic transmission and widespread dissemination of the parasite. In this review, we discuss the evidence showing how the clinically relevant process of bradyzoite differentiation is regulated at both transcriptional and post-transcriptional levels. Specific regulatory factors implicated in modulating bradyzoite differentiation include promoter-based cis-elements, epigenetic modifications and protein translation control through eukaryotic initiation factor -2 (eIF2. In addition to a summary of the current state of knowledge in these areas we discuss the pharmacological ramifications and pose some questions for future research.

  5. Latest developments in our understanding of the pathogenesis of mesothelioma and the design of targeted therapies.

    Science.gov (United States)

    Bononi, Angela; Napolitano, Andrea; Pass, Harvey I; Yang, Haining; Carbone, Michele

    2015-10-01

    Malignant mesothelioma is an aggressive cancer whose pathogenesis is causally linked to occupational exposure to asbestos. Familial clusters of mesotheliomas have been observed in settings of genetic predisposition. Mesothelioma incidence is anticipated to increase worldwide in the next two decades. Novel treatments are needed, as current treatment modalities may improve the quality of life, but have shown modest effects in improving overall survival. Increasing knowledge on the molecular characteristics of mesothelioma has led to the development of novel potential therapeutic strategies, including: molecular targeted approaches, that is the inhibition of vascular endothelial growth factor with bevacizumab; immunotherapy with chimeric monoclonal antibody, immunotoxin, antibody drug conjugate, vaccine and viruses; inhibition of asbestos-induced inflammation, that is aspirin inhibition of HMGB1 activity may decrease or delay mesothelioma onset and/or growth. We elaborate on the rationale behind new therapeutic strategies, and summarize available preclinical and clinical results, as well as efforts still ongoing.

  6. Den gode handling og den gode grund

    DEFF Research Database (Denmark)

    Dehs, Jørgen

    1993-01-01

    Den tyske filosof Immanuel Kant er aktuel i dagens etik-debat. "Grundlæggelse af moralens metafysik".......Den tyske filosof Immanuel Kant er aktuel i dagens etik-debat. "Grundlæggelse af moralens metafysik"....

  7. Understanding the impact of infection, inflammation and their persistence in the pathogenesis of bronchopulmonary dysplasia

    Directory of Open Access Journals (Sweden)

    Jherna eBalany

    2015-12-01

    Full Text Available The concerted interaction of genetic and environmental factors act on the preterm human immature lung with inflammation being the common denominator leading to the multifactorial origin of the most common chronic lung disease in infants – bronchopulmonary dysplasia or BPD. Adverse perinatal exposure to infection/inflammation with added insults like invasive mechanical ventilation, exposure to hyperoxia and sepsis causes persistent immune dysregulation. In this review article we have attempted to analyze and consolidate current knowledge about the role played by persistent prenatal and postnatal inflammation in the pathogenesis of BPD. While some parameters of the early inflammatory response (neutrophils, cytokines etc. may not be detectable after days to weeks of exposure to noxious stimuli, they have already initiated the signaling pathways of the inflammatory process / immune cascade and have affected permanent defects structurally and functionally in the BPD lungs. Hence translational research aimed at prevention / amelioration of BPD needs to focus on dampening the inflammatory response at an early stage to prevent the cascade of events leading to lung injury with impaired healing resulting in the pathologic pulmonary phenotype of alveolar simplification and dysregulated vascularization characteristic of BPD.

  8. Understanding the Impact of Infection, Inflammation, and Their Persistence in the Pathogenesis of Bronchopulmonary Dysplasia.

    Science.gov (United States)

    Balany, Jherna; Bhandari, Vineet

    2015-01-01

    The concerted interaction of genetic and environmental factors acts on the preterm human immature lung with inflammation being the common denominator leading to the multifactorial origin of the most common chronic lung disease in infants - -bronchopulmonary dysplasia (BPD). Adverse perinatal exposure to infection/inflammation with added insults like invasive mecha nical ventilation, exposure to hyperoxia, and sepsis causes persistent immune dysregulation. In this review article, we have attempted to analyze and consolidate current knowledge about the role played by persistent prenatal and postnatal inflammation in the pathogenesis of BPD. While some parameters of the early inflammatory response (neutrophils, cytokines, etc.) may not be detectable after days to weeks of exposure to noxious stimuli, they have already initiated the signaling pathways of the inflammatory process/immune cascade and have affected permanent defects structurally and functionally in the BPD lungs. Hence, translational research aimed at prevention/amelioration of BPD needs to focus on dampening the inflammatory response at an early stage to prevent the cascade of events leading to lung injury with impaired healing resulting in the pathologic pulmonary phenotype of alveolar simplification and dysregulated vascularization characteristic of BPD.

  9. Hvad er tannlegeskrekk, og hvordan kan den diagnostiseres? [Understanding dental fear, anxiety and phobia: Implications for the assessment and diagnostics

    DEFF Research Database (Denmark)

    Kvale, G.; Klingberg, G.; Moore, R.

    2003-01-01

    English summary Understanding dental fear, anxiety and phobia: Implications for assessment and diagnostics Assessment of dental fear, anxiety and phobia is essential for treatment planning and for evaluation of treatment effects. In order to employ adequate assessments, it is essential to have...... a basic understanding of psychological reactions such as anxiety and phobia. In the current paper, dental anxiety and phobia are understood as learned behavioral patterns originating from one’s adaptive fear responses. These patterns include cognitions and physiological reactions as well as behavioural...... responses such as avoidance of dental care. The most common model for understanding the development of dental anxiety and phobia is presented, as well as established diagnostic criteria for dental phobia. The paper also describes various tools for measuring the different phenomena and discusses how...

  10. Den unge Heidegger

    DEFF Research Database (Denmark)

    Den første antologi på dansk om den unge Heideggers skrifter og udviklingen før Væren og tid......Den første antologi på dansk om den unge Heideggers skrifter og udviklingen før Væren og tid...

  11. Advances in our understanding of the pathogenesis of hemolytic uremic syndromes.

    Science.gov (United States)

    Bowen, E E; Coward, R J

    2018-03-01

    Hemolytic uremic syndrome (HUS) is major global health care issue as it is the leading cause of acute kidney injury in children. It is a triad of acute kidney injury, microangiopathic hemolytic anemia, and thrombocytopenia. In recent years, major advances in our understanding of complement-driven inherited rare forms of HUS have been achieved. However, in children 90% of cases of HUS are associated with a Shiga toxin-producing enteric pathogen. The precise pathological mechanisms in this setting are yet to be elucidated. The purpose of this review is to discuss advances in our understanding of the pathophysiology underlying HUS and identify the key questions yet to be answered by the scientific community.

  12. Small animal models to understand pathogenesis of osteoarthritis and use of stem cell in cartilage regeneration.

    Science.gov (United States)

    Piombo, Virginia

    2017-01-01

    Osteoarthritis (OA) is one of the most common diseases, which affect the correct functionality of synovial joints and is characterized by articular cartilage degradation. Limitation in the treatment of OA is mostly due to the very limited regenerative characteristic of articular cartilage once is damaged. Small animal models are of particular importance for mechanistic analysis to understand the processes that affect cartilage degradation. Combination of joint injury techniques with the use of stem cells has been shown to be an important tool for understanding the processes of cartilage degradation and regeneration. Implementation of stem cells and small animal models are important tools to help researchers to find a solution that could ameliorate and prevent the symptoms of OA. Copyright © 2017 John Wiley & Sons, Ltd.

  13. Basal Cell Carcinoma: From the Molecular Understanding of the Pathogenesis to Targeted Therapy of Progressive Disease

    Directory of Open Access Journals (Sweden)

    Daniela Göppner

    2011-01-01

    Full Text Available Due to intensified research over the past decade, the Hedgehog (HH pathway has been identified as a pivotal defect implicated in roughly 25% of all cancers. As one of the most frequent cancer worldwide, the development of Basal cell carcinoma (BCC due to activation of the HH pathway has been convincingly demonstrated. Thus the discovery of this central tumor-promoting signalling pathway has not only revolutionized the understanding of BCC carcinogenesis but has also enabled the development of a completely novel therapeutic approach. Targeting just a few of several potential mutations, HH inhibitors such as GDC-0449 achieved already the first promising results in metastatic or locally advanced BCC. This paper summarizes the current understanding of BCC carcinogenesis and describes the current “mechanism-based” therapeutic strategies.

  14. Imaging lymphoid tissues in nonhuman primates to understand SIV pathogenesis and persistence.

    Science.gov (United States)

    Deleage, Claire; Turkbey, Baris; Estes, Jacob D

    2016-08-01

    CD4+ T cells are the primary HIV-1 target cell, with the vast majority of these cells residing within lymphoid tissue compartments throughout the body. Predictably, HIV-1 infection, replication, localization, reservoir establishment and persistence, as well as associated host immune and inflammatory responses and disease pathology principally take place within the tissues of the immune system. By virture of the fact that the virus-host struggle is played out within lymphoid and additional tissues compartments in HIV-1 infected individuals it is critical to understand HIV-1 infection and disease within these relevant tissue sites; however, there are obvious limitations to studying these dynamic processes in humans. Nonhuman primate (NHP) research has provided a vital bridge between basic and preclinical research and clinical studies, with experimental SIV infection of NHP models offering unique opportunities to understand key processes of HIV-1 infection and disease that are either not practically feasible or ethical in HIV-1 infected humans. In this review we will discuss current approaches to studying the tissue based immunopathogenesis of AIDS virus infection in NHPs, including both analyses of tissues obtained at biopsy or necropsy and complementary non-invasive imaging approaches that may have practical utility in monitoring HIV-1 disease in the clinical setting. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Towards Better Understanding of the Pathogenesis of Neuronal Respiratory Network in Sudden Perinatal Death

    Directory of Open Access Journals (Sweden)

    Riffat Mehboob

    2017-07-01

    Full Text Available Sudden perinatal death that includes the victims of sudden infant death syndrome, sudden intrauterine death syndrome, and stillbirth are heartbreaking events in the life of parents. Most of the studies about sudden perinatal death were reported from Italy, highlighting two main etiological factors: prone sleeping position and smoking. Other probable contributory factors are prematurity, male gender, lack of breastfeeding, respiratory tract infections, use of pacifiers, infant botulism, extensive use of pesticides and insecticides, etc. However, extensive studies across the world are required to establish the role of these factors in a different subset of populations. Previous studies confirmed the widely accepted hypothesis that neuropathology of the brainstem is one of the main cause of sudden perinatal death. This study is an effort to summarize the neuropathological evaluation of the brainstems and their association to sudden perinatal death. Brainstem nuclei in vulnerable infants undergo certain changes that may alter the sleep arousal cycle, cardiorespiratory control, and ultimately culminate in death. This review focuses on the roles of different brainstem nuclei, their pathologies, and the established facts in this regard in terms of it’s link to such deaths. This study will also help to understand the role of brainstem nuclei in controlling the cardiorespiratory cycles in sudden perinatal death and may provide a better understanding to resolve the mystery of these deaths in future. It is also found that a global initiative to deal with perinatal death is required to facilitate the diagnosis and prevention in developed and as well as developing countries.

  16. Progress in understanding the pathogenesis of BPD using the baboon and sheep models.

    Science.gov (United States)

    Albertine, Kurt H

    2013-04-01

    Bronchopulmonary dysplasia (BPD) is among the most common chronic lung diseases in infants in the US. Improved survival of preterm infants who developed BPD is becoming increasingly important because of the high risk for persistent pulmonary morbidities such as poor respiratory gas exchange, pulmonary hypertension, and excess airway expiratory resistance later in life. This review focuses on unique insights provided by the two large-animal, physiological models of neonatal chronic lung disease: preterm baboons and preterm lambs. The models' are valuable because they contribute to better understanding of the underlying molecular pathogenic mechanisms. An epigenetic hypothesis is proposed as a pathogenic mechanism for BPD and its persistent pulmonary morbidities. Copyright © 2013 Elsevier Inc. All rights reserved.

  17. Den Russiske Revolution

    DEFF Research Database (Denmark)

    Den Russiske Revolution er en af de mest afgørende politiske og sociale begivenheder i det 20. århundredes historie. Den skabte de ideologiske og geopolitiske parametre, der dominerede verden frem til 1991 - og på mange måder stadig gør det. Fortolkningen af Den Russiske Revolution har været et...

  18. Den umulige film

    DEFF Research Database (Denmark)

    Moestrup, Steffen Damkjær

    2014-01-01

    Den smertelige Sorg og Glæde fuldender en lang og glorværdig karriere for danske Nils Malmros. Den er en yderst vellykket film, fordi den forbliver usentimental om en skæbnesvanger dag i instruktørens liv....

  19. Den canadiske model

    DEFF Research Database (Denmark)

    Böss, Michael

    2009-01-01

    Det har altid været en amerikansk fordom, at Canada er et kedeligt land. Men i lyset af den finansielle krise, er den fordom sværere at holde fast i. Nabolandet mod nord, hvor hverken socialisme eller radikal liberalisme har nydt stor udbredelse, og hvor den finansielle sektor i lang tid har været...

  20. Den amerikanske udfordring

    DEFF Research Database (Denmark)

    Böss, Michael

    1994-01-01

    stalinistiske Bulgarien. Opgøret med den strukturalistiske skole, han selv var med til at danne, satte specielt ind efter hans genlæsning af Mikail Bakhtin i begyndelsen af 1970'erne. Nu vender han sig mod den relativisme, som både denne og den post-koloniale amerikanske kritik er udtryk for....

  1. Genomic analysis of a ginger pathogen Bacillus pumilus providing the understanding to the pathogenesis and the novel control strategy.

    Science.gov (United States)

    Yuan, Yihui; Gao, Meiying

    2015-05-19

    Bacillus pumilus has been widely identified as a pathogen of plant and human, while the genetic information is rarely available for pathogenic B. pumilus strains. B. pumilus GR8 is a pathogen that causes ginger rhizome rot disease by invading ginger rhizome parenchymatous tissues, growing in the extracellular space, and producing plant cell wall-degrading enzymes to destroy ginger cells. In this study, the genome of GR8 was sequenced and characterized. This genome was the third completely sequenced genome of the B. pumilus species, and it exhibited high similarity to the genome of the B. pumilus strain B6033. The genome of GR8 was 3.67 Mb in length and encoded 3,713 putative ORFs. Among these predicted proteins, numerous plant cell wall-degrading enzymes and several proteins associated with invading and adapting to the environment in the extracellular space of the ginger rhizome parenchymatous tissue were found. The GR8 genome contained only one restriction-modification system and no CRISPR/Cas system. The lack of phage-resistant system suggested that phages might be potential agents for the control of GR8. The genomic analysis of GR8 provided the understanding to the pathogenesis and the phage-control strategy of pathogenic B. pumilus strains.

  2. The TRIPS (Toll-like receptors in immuno-inflammatory pathogenesis) Hypothesis: a novel postulate to understand schizophrenia.

    Science.gov (United States)

    Venkatasubramanian, Ganesan; Debnath, Monojit

    2013-07-01

    Mounting evidence indicates that immune activation and/or immuno-inflammatory reactions during neurodevelopment apparently contribute to the pathogenesis and progression of schizophrenia. One of the important environmental factors that is known to trigger immune activation/inflammatory responses during early pregnancy is prenatal infection. Recent understanding from animal studies suggests that prenatal infection induced maternal immune activation (MIA)/inflammation in congruence with oxidative/nitrosative stress can lead to neurodevelopmental damage and behavioral abnormalities in the offspring. Although the underlying precise mechanistic processes of MIA/inflammation are yet to be completely elucidated, it is being increasingly recognized that Toll-like receptors (TLRs) that form the first line of defense against invading microorganisms could participate in the prenatal infection induced immune insults. Interestingly, some of the TLRs, especially TLR3 and TLR4 that modulate neurodevelopment, neuronal survival and neuronal plasticity by regulating the neuro-immune cross-talk in the developing and adult brain could also be affected by prenatal infection. Importantly, sustained activation of TLR3/TLR4 due to environmental factors including infection and stress has been found to generate excessive reactive oxygen species (ROS)/reactive nitrogen species (RNS) as well as pro-inflammatory mediators during embryogenesis, which result into neuronal damage by necrosis/apoptosis. In recent times, ROS/RNS and immuno-inflammatory mediators are being increasingly linked to progressive brain changes in schizophrenia. Although a significant role of TLR3/TLR4 in neurodegeneration is gaining certainty, their importance in establishing a causal link between prenatal infection and immuno-inflammatory, oxidative and nitrosative stress (IO&NS) responses and influence on adult presentation of schizophrenia is yet to be ascertained. We review here the current knowledge generated from

  3. Polar bear maternity denning in the Beaufort Sea

    Science.gov (United States)

    Amstrup, Steven C.; Gardner, Craig L.

    1994-01-01

    The distribution of polar bears (Ursus maritimus) is circumpolar in the NOrthern Hemisphere, but known locations of maternal dens are concentrated in relatively few, widely scattered locations. Denning is either uncommon or unknown within gaps. To understand effects of industrial development and propose increases in hunting, the temporal and spatial distribution of denning in the Beaufort Sea must be known. We caputred and radiocollared polar bears between 1981 and 1991 and determined tht denning in the Beaufort Sea region was sufficient to account for the estimated population there. Of 90 dend, 48 were on drifting pack ice, 38 on land, and 4 on land-fast ice. The portions of dens on land was higher (P= 0.029) in later compared with earlier years of the study. Bears denning on pack ice drifting as far as 997 km (x=385km) while in dens. there was no difference in cun production by bears denning on land and pack ice (P =0.66). Mean entry and exit dates were 11 November and 5 April for land dens and 22 November and 26 March for pack-ice dens. Female polar bears captured in the Beaufort Sea appeared to be isolated from those caught eat of Cape Bathurst in Canada. Of 35 polar bears that denned along the mainland coast of Alaska and Canada 80% denned between 137 00'W snf 146 59'W. Bears followed to >1 den did not reuse sites and consecutive dens were 20-1,304 km apart. However radio-collared bears are largely faithful to substrate (pack-ice, land, and land-fast ice) and the general geographic area of previous dens. Bears denning on land may be vunerable to human activities such as hunting and industrial development. However, predictable denning chronology and alck of site fidelity indicate that many potential impacts on denning polar bears could be mitigated.

  4. "Den onde kvinde"

    DEFF Research Database (Denmark)

    Holst, Søren

    2002-01-01

    Et af Dødehavsskrifterne, af den første udgiver kaldet "Den onde kvindes rænker" (4Q184), beskriver en svigefuld kvinde, der lokker fromme mænd i fordærv. Artiklen gennemgår tekstens fortolkningshistorie og påviser den rolle, det har spillet for læsningen, at teksten a priori er blevet opfattet s...

  5. Den inkluderende skole

    DEFF Research Database (Denmark)

    Hedegaard Hansen, Janne

    2009-01-01

    Artiklen tager afsæt i en forståelse af inklusion som den enkelte elevs ret til deltagelse i de eksisterende fællesskaber, forstået som de læringsrum, der bedst muligt tilgodeser den enkelte elevs særlige behov. I artiklen diskuteres hvilke nødvendige forandringer det fordrer i den pædagogiske pr...

  6. Den katolske kirke

    DEFF Research Database (Denmark)

    Olden-Jørgensen, Sebastian

    2009-01-01

    En kort gennemgang af den katolske kirkes kirkerum, ritualer, selvforståelse og syn på andre kristne efterfulgt af 16 forskellige kildetekster til belysning og uddybning af emnerne. Bogen omfatter tilsvarende afsnit om de ortodokse kirker og om folkekirken. Den er beregnet til gymnasium og HF....

  7. Den lille levnedsmiddeltabel

    DEFF Research Database (Denmark)

    Saxholt, Erling; Fagt, Sisse; Matthiessen, Jeppe

    Den lille levnedsmiddeltabel er en oversigt over indholdet af næringsstoffer i næsten 600 af de mest anvendte fødevarer i den danske kost. Herudover rummer bogen anvisninger til anvendelsen af fødevaredata....

  8. Den moderate revolution

    DEFF Research Database (Denmark)

    Larsen, Bøje

    "normale" industrivirksomheder, men den er absolut set begrænset. Årsagerne til denne kun "moderate revolution" af organisationsformerne diskuteres: Er det fordi klassisk organisation og social nærkontakt er nødvendig i den nye økonomi, eller er det manglende fantasi og tryghedsbehov? Begge muligheder...

  9. Epigenetics: The missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes

    OpenAIRE

    Gilbert, Elizabeth R.; Liu, Dongmin

    2012-01-01

    Type 2 diabetes (T2D) is a growing health problem worldwide. While peripheral insulin resistance is common during obesity and aging in both animals and people, progression to T2D is largely due to insulin secretory dysfunction and significant apoptosis of functional β-cells, leading to an inability to compensate for insulin resistance. It is recognized that environmental factors and nutrition play an important role in the pathogenesis of diabetes. However, our knowledge surrounding molecular ...

  10. DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions

    Science.gov (United States)

    Arjunan, Selvam; Sastri, Narayan P.; Chandra, Nagasuma

    2016-01-01

    Dengue virus (DENV) is a human pathogen and its etiology has been widely established. There are many interactions between DENV and human proteins that have been reported in literature. However, no publicly accessible resource for efficiently retrieving the information is yet available. In this study, we mined all publicly available dengue–human interactions that have been reported in the literature into a database called DenHunt. We retrieved 682 direct interactions of human proteins with dengue viral components, 382 indirect interactions and 4120 differentially expressed human genes in dengue infected cell lines and patients. We have illustrated the importance of DenHunt by mapping the dengue–human interactions on to the host interactome and observed that the virus targets multiple host functional complexes of important cellular processes such as metabolism, immune system and signaling pathways suggesting a potential role of these interactions in viral pathogenesis. We also observed that 7 percent of the dengue virus interacting human proteins are also associated with other infectious and non-infectious diseases. Finally, the understanding that comes from such analyses could be used to design better strategies to counteract the diseases caused by dengue virus. The whole dataset has been catalogued in a searchable database, called DenHunt (http://proline.biochem.iisc.ernet.in/DenHunt/). PMID:27618709

  11. Denver District Laboratory (DEN)

    Data.gov (United States)

    Federal Laboratory Consortium — Program CapabilitiesDEN-DO Laboratory is a multi-functional laboratory capable of analyzing most chemical analytes and pathogenic/non-pathogenic microorganisms found...

  12. Den signede dag

    DEFF Research Database (Denmark)

    Balslev-Clausen, Peter

    2010-01-01

    Artiklen gennemgår de tre middelalderlige versioner af den fællesnordiske dagvise fra 14. århundrede og gør rede for salmens tekst- og receptionshistorie i Dansk tradition.......Artiklen gennemgår de tre middelalderlige versioner af den fællesnordiske dagvise fra 14. århundrede og gør rede for salmens tekst- og receptionshistorie i Dansk tradition....

  13. Den antikke katapults udvikling

    DEFF Research Database (Denmark)

    Paasch, Kasper

    2011-01-01

    Hvordan bygger man en katapult? Dette spørgsmål belyses ved at se på den græske og romerske katapults udviklingshistorie samt på den forskningshistoriske tilgang til emnet, hovedsageligt set ud fra et ingeniørmæssig/matematisk synspunkt. Katapulten menes opfundet år 399 f.Kr. og blot ca. 120-150 ...

  14. Dens invaginatus: a case report.

    Science.gov (United States)

    Choudhari, Shantanu; Joshi, Saurabh; Patil, Namrata; Kalyan, Sai

    2013-03-01

    Dens invaginatus, also known as dens in dente, is a rare anomaly affecting human dentition. The condition results in invagination of an amelodental structure within the pulp. This case report discusses the current management protocol of dens invaginatus as demonstrated in an adolescent female and describes treatment options. As with most conditions, early diagnosis and preventive measures help minimize complications in dens invaginatus cases.

  15. Den Russiske Revolution

    DEFF Research Database (Denmark)

    Den Russiske Revolution er en af de mest afgørende politiske og sociale begivenheder i det 20. århundredes historie. Den skabte de ideologiske og geopolitiske parametre, der dominerede verden frem til 1991 - og på mange måder stadig gør det. Fortolkningen af Den Russiske Revolution har været et...... afgørende stridspunkt i det 20. århundredes politiske og filosofiske diskussioner. I denne bog gives der plads til en række af revolutionens egne stemmer. Bogen indeholder en lang række primærtekster fra Den Russiske Revolution - fra den første revolution i 1905 og frem til nedkæmpelsen af Kronstadt......-oprøret i 1921, med fokus på revolutionsåret 1917. Sammen med revolutionens artikler, bøger, dekreter, taler, digte og slagord indeholder bogen en introduktion og en tidslinje, der giver læseren overblik over de historiske begivenheder og idémæssige strømninger, der udgjorde Den Russiske Revolution....

  16. Development of in vitro models for a better understanding of the early pathogenesis of Batrachochytrium dendrobatidis infections in amphibians.

    Science.gov (United States)

    Van Rooij, Pascale; Martel, An; Brutyn, Melanie; Maes, Sofie; Chiers, Koen; Van Waeyenberghe, Lieven; Croubels, Siska; Haesebrouck, Freddy; Pasmans, Frank

    2010-12-01

    Batrachochytrium dendrobatidis, the causal agent of chytridiomycosis, is implicated in the global decline of amphibians. This chytrid fungus invades keratinised epithelial cells, and infection is mainly associated with epidermal hyperplasia and hyperkeratosis. Since little is known about the pathogenesis of chytridiomycosis, this study was designed to optimise the conditions under which primary keratinocytes and epidermal explants of amphibian skin could be maintained ex vivo for several days. The usefulness of the following set-ups for pathogenesis studies was investigated: a) cultures of primary keratinocytes; b) stripped epidermal (SE) explants; c) full-thickness epidermal (FTE) explants on Matrigel™; d) FTE explants in cell culture inserts; and e) FTE explants in Ussing chambers. SE explants proved most suitable for short-term studies, since adherence of fluorescently-labelled zoospores to the superficial epidermis could be observed within one hour of infection. FTE explants in an Ussing chamber set-up are most suitable for the study of the later developmental stages of B. dendrobatidis in amphibian skin up to five days post-infection. These models provide a good alternative for in vivo experiments, and reduce the number of experimental animals needed. 2010 FRAME.

  17. Den teoretiske side

    DEFF Research Database (Denmark)

    Bengtsson, Mette

    2013-01-01

    Hvis man bruger dem dygtigt og raffineret, kan rim og rytme have en overbevisende virkning på publikum. Men der er fare for at det bliver påtaget, påklistret og for meget, og så risikerer man den modsatte effekt......Hvis man bruger dem dygtigt og raffineret, kan rim og rytme have en overbevisende virkning på publikum. Men der er fare for at det bliver påtaget, påklistret og for meget, og så risikerer man den modsatte effekt...

  18. Den udenlandske udtales finurligheder

    DEFF Research Database (Denmark)

    Davidsen-Nielsen, Niels

    2017-01-01

    Eftertanken. Det er ikke altid nemt at tale om store, internationale kunstnere som Mozart eller Gabriel García Márquez. For hvordan skal den danske mund udtale z'et i Mozart og lægge trykket i García?......Eftertanken. Det er ikke altid nemt at tale om store, internationale kunstnere som Mozart eller Gabriel García Márquez. For hvordan skal den danske mund udtale z'et i Mozart og lægge trykket i García?...

  19. Understanding HIV infection for the design of a therapeutic vaccine. Part I: Epidemiology and pathogenesis of HIV infection.

    Science.gov (United States)

    de Goede, A L; Vulto, A G; Osterhaus, A D M E; Gruters, R A

    2015-03-01

    HIV infection leads to a gradual loss CD4+ T lymphocytes comprising immune competence and progression to AIDS. Effective treatment with combined antiretroviral drugs (cART) decreases viral load below detectable levels but is not able to eliminate the virus from the body. The success of cART is frustrated by the requirement of expensive life-long adherence, accumulating drug toxicities and chronic immune activation resulting in increased risk of several non-AIDS disorders, even when viral replication is suppressed. Therefore there is a strong need for therapeutic strategies as an alternative to cART. Immunotherapy, or therapeutic vaccination, aims to increase existing immune responses against HIV or induce de novo immune responses. These immune responses should provide a functional cure by controlling viral replication and preventing disease progression in the absence of cART. The key difficulty in the development of an HIV vaccine is our ignorance of the immune responses that control of viral replication, and thus how these responses can be elicited and how they can be monitored. Part one of this review provides an extensive overview of the (patho-) physiology of HIV infection. It describes the structure and replication cycle of HIV, the epidemiology and pathogenesis of HIV infection and the innate and adaptive immune responses against HIV. Part two of this review discusses therapeutic options for HIV. Prevention modalities and antiretroviral therapy are briefly touched upon, after which an extensive overview on vaccination strategies for HIV is provided, including the choice of immunogens and delivery strategies. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  20. Efterskrift til den reviderede udgave

    DEFF Research Database (Denmark)

    Nielsen, Carsten Fogh

    2017-01-01

    Opsummering af tendenser og udviklingstræk inden for den nyere forskning i Kants historiefilosofi.......Opsummering af tendenser og udviklingstræk inden for den nyere forskning i Kants historiefilosofi....

  1. Den unge Burkes Satire

    DEFF Research Database (Denmark)

    Ørndorf, Steen

    Edmund Burke (1730-1797) er i nyere tid blevet politisk ikon, kendt som konservatismens fader. Berømmelsen skyldes hovedværket fra 1790, Reflections on the Revolution in France, som er et angreb på den franske revolution. Ungdomsarbejdet A Vindication of Natural Society er fra 1756 og har status ...

  2. Den interkonfessionelle dialog

    DEFF Research Database (Denmark)

    Pedersen, Else Marie Wiberg

    2006-01-01

    På baggrund af en gennemgang af det 20. århundredes økumeniske hermeneutik, foreslås det i denne artikel, at den økumeniske dialog (et ord, som oversættes forskelligt af de forskellige konfessioner) erstattes af en økumenisk diskurs (jf. Michel de Certau og Lukas Vischer). Der plæderes således...

  3. Den danske regionskonstruktion

    DEFF Research Database (Denmark)

    Klausen, Kurt Klaudi; Christoffersen, Henrik

    Region Midtjylland er i centrum for analysen men den omfatter også regionsdannelsen i almindelighed. Der anlægges i analysen på samme tid et politologisk, organisationsteoretisk og økonomisk resonnement. Regionsdannelsen finder sted på baggrund af de setup Strukturreformen har sat, men udfoldes p...

  4. Den borgerlige orden

    DEFF Research Database (Denmark)

    Forskningsbaseret antologi om forholdet mellem den borgerlige orden og kultur. I bogen diskuterer 12 yngre konservative og liberale skribenter det kulturelle grundlag for en borgerlig orden baseret på frihed, tillid og velstand. Her er essays om religion, marked, sammenhængskraft, retssamfund...

  5. Den materielle drejning

    DEFF Research Database (Denmark)

    Skiveren, Tobias; Gregersen, Martin

    2015-01-01

    Ved at trække på en række forskellige tænkere som Jane Bennett, Arne Næss, Donna Haraway og Karan Barad relaterer artiklen den såkaldte materielle drejning til tre filosofisk-teoretiske nyorienteringer: økokritik, det posthumane og kropsmaterialisme. Tesen er, at interaktionenen mellem disse...

  6. Den offentlige driftsorganisation

    DEFF Research Database (Denmark)

    Voxted, Søren

    2010-01-01

    styringsmodel med dens klare rollefordelinger til en mere fl eksibel struktur. Det er artiklens formål at opstille en model for, hvordan denne driftsorganisation ser ud strukturelt. Her udgør det artiklens tese, at der er skabt en driftsorganisation uden klare og markante positioner. Mest tydeligt kommer dette...

  7. Den menneskelige eksistens

    DEFF Research Database (Denmark)

    tilværelse. Dermed tilbyder den et bedre grundlag for at forstå fremtrædende kultursociologiske og socialpsykologiske problemer som identitetsusikkerhed, angst og raseri såvel som frigørende muligheder for engagement og kreativitet. Foruden originale tekster af Merleau-Ponty, Ricœur og Waldenfels rummer...

  8. Den sundhedsvidenskabelige opgave

    DEFF Research Database (Denmark)

    Lindahl, Marianne Pia; Juhl, Carsten Bogh

    troværdigheden af sine resultater. Bogen er opdateret, så den refererer til Microsoft Office 2013, og giver instruktioner og tips til: • Hvordan man bruger Word til hjælp med indholdsfortegnelse, overskrifter og korrektur • Hvordan man bruger Word til hjælp med diagrammer og tabeller• Hvordan man bruger Excel...

  9. Den kinesiske krimi

    DEFF Research Database (Denmark)

    Hansen, Kim Toft

    2011-01-01

    retssag på dansk. Betegnelserne krimi eller det engelske crime fiction bruges sjældent på en tilsvarende måde på kinesisk, selvom udtrykket findes (zuian xiaoshuo). Traditionelt bruges i stedet gongan eller gongan wenxue, der hhv. betyder retssag og retssagslitteratur, hvor det tætteste den vestlige...

  10. Den postmoderne konstruktivismes inkongruenser

    DEFF Research Database (Denmark)

    Cristoffanini, Pablo Rolando

    2011-01-01

    europæiske intellektuelle og akademikere gjorde teorierne og ideerne om underudvikling og afhængighed, der stammede fra Latinamerika, til deres egne. Også i den sidste tid har latinamerikanske intellektuelle, som fx Nestor García Canclini, haft indflydelse i Europa og USA med sin teori om hybriditet og...

  11. Den moderne bevidstheds katedral

    DEFF Research Database (Denmark)

    Ostenfeld Pedersen, Simon

    2002-01-01

    Interview med idéhistorikeren Dorthe Jørgensen der under overskriften ”Den moderne bevidstheds katedral” blotlægger hendes mangeårige arbejde med Hegel, og hvor hun giver en række relevante bud på en aktualiserende Hegel-læsning centreret omkring felter som metafysik, historiefilosofi og æstetik....

  12. Den Danske Løsning

    DEFF Research Database (Denmark)

    Langsted, Lars Bo

    1999-01-01

    Artiklen rummer en (foreløbig) kommentar til den såkaldte Hafnia-dom, hvor Den Danske Bank og revisorerne blev fundet erstatningsansvarlige for et misvisende prospekt i forbindelse med en fondsbørsemission.......Artiklen rummer en (foreløbig) kommentar til den såkaldte Hafnia-dom, hvor Den Danske Bank og revisorerne blev fundet erstatningsansvarlige for et misvisende prospekt i forbindelse med en fondsbørsemission....

  13. Hvad karakteriserer den netbaserede vejledning?

    DEFF Research Database (Denmark)

    Kjeldsen, Lars Peter

    2008-01-01

    Hensigten med artiklen er at bidrage til forståelsen af sider ved den netbaserede vejledning. Fremgangsmåden vil være: •Først at beskrive og diskutere, hvorledes jeg forstår det virtuelle læringsmiljø, herunder en afklaring af, hvad der karakteriserer den netbaserede vejledning. •Dernæst gennem e...

  14. Kollegaerne er den nye chef

    DEFF Research Database (Denmark)

    Fugl, Marie

    2008-01-01

    Den tid, hvor chefen var den, der delte skideballer ud, er slut. Rollen som 'bad cop' er overtaget af kollegateamet, der med hård hånd sørger for, at den enkelte yder sin del. Udgivelsesdato: November...

  15. Den sociale stofmisbrugsbehandling. Del 4

    DEFF Research Database (Denmark)

    Sørensen, Maren

    Dette er den fjerde delrapport i en rapportserie om den sociale stofmisbrugsbehandling i Danmark. Rapportserien bygger på en omfattende undersøgelse, der blev fortaget i perioden december 2007 til maj 2009. Denne delrapport stiller skarpt på kvalitetsudvikling og kvalitetsstandarder i den sociale...

  16. Dannelsen af den ansvarlige elev

    DEFF Research Database (Denmark)

    Larsen, Jesper

    2010-01-01

    Denne artikel handler om den del af lærergerningen, der har at gøre med udarbejdelse af elevplaner. Der tages udgangspunkt i en foucaultsk forståelse, hvor beskrivelsen af den enkelte elev udtrykker et særligt normativt ideal om, hvilke former for elevhed der er de ønskværdige i den danske...

  17. Double dens invaginatus in an impacted molariform supernumerary tooth: An unique case

    Directory of Open Access Journals (Sweden)

    Anegundi R

    2008-05-01

    Full Text Available Dens invaginatus is a relatively rare developmental anomaly affecting usually the permanent maxillary lateral incisor. Various factors have been put forward regarding its pathogenesis. Involvement of crown/root has been reported as the coronal and radicular variety of dens invaginatus. One of the rarest variant is the Double dens invaginatus and only a few cases have been reported in the literature.This article focuses on a case of double dens invaginatus in an impacted maxillary anterior supernumerary tooth, the associated complications and its management

  18. Double dens invaginatus in an impacted molariform supernumerary tooth: a unique case.

    Science.gov (United States)

    Anegundi, R T; Kaveri, H; Patil, Shruthi B; Punnya, A

    2008-01-01

    Dens invaginatus is a relatively rare developmental anomaly affecting usually the permanent maxillary lateral incisor. Various factors have been put forward regarding its pathogenesis. Involvement of crown/root has been reported as the coronal and radicular variety of dens invaginatus. One of the rarest variant is the Double dens invaginatus and only a few cases have been reported in the literature.This article focuses on a case of double dens invaginatus in an impacted maxillary anterior supernumerary tooth, the associated complications and its management.

  19. Recent advances in understanding the role of adipocytokines during non-alcoholic fatty liver disease pathogenesis and their link with hepatokines.

    Science.gov (United States)

    Panera, Nadia; Della Corte, Claudia; Crudele, Annalisa; Stronati, Laura; Nobili, Valerio; Alisi, Anna

    2016-01-01

    Non-alcoholic fatty liver disease (NAFLD) is currently considered the main cause of chronic liver disease worldwide. Mechanisms leading to the development and progression of this disease are topics of great interest for researchers and clinicians. The current multi-hit hypothesis has thrown the crosstalk between liver and adipose tissue into sharp focus. It is well known that adipose tissue produces circulating factors, known as adipocytokines, which exert several effects on liver cells, promoting the onset of NAFLD and its progression to non-alcoholic steatohepatitis in obese subjects. In a similar way, hepatocytes may also respond to obesogenic stimuli by producing and releasing hepatokines into the circulation. Here, the authors provide an overview of recent advances in our understanding of the role of the most relevant adipocytokines and hepatokines in NAFLD pathogenesis, highlighting their possible molecular and functional interactions.

  20. dens festival

    DEFF Research Database (Denmark)

    Agerholm, Frank Juul

    2012-01-01

    Som den italienske antropolog og folklorist Alessandro Falassi gør opmærksom på i antologien Time out of Time: Essays on the Festival, så er det sparsomt, hvad der er gjort af teoretiske forsøg på definere, hvad en festival er. Det står altså skidt til med et begreb om festivalen, og dette endog...... til trods for, at der er forsket i festivalen som fænomen siden det 19. århundrede – tilmed inden for en række forskellige faglige discipliner såsom religionsvidenskab, sociologi, antropologi, folklore m.fl. Endnu mere sparsomt må det vel så også stå til med bud på, hvad fødens festival er for en...

  1. Den fatale kollision?

    DEFF Research Database (Denmark)

    Thyssen, Ole

    2013-01-01

    Alle grene af samfundet trækker i retning af øget vækst, som skaber arbejdspladser og bedre forbrugsmuligheder. Men det kolliderer med en økologisk nødvendighed, der siger, at der er grænser for vækst. Hvorfra skal omstillingen hente sin energi, så den er mere end en uforpligtende dagdrøm?...

  2. Den Magiske Kugle

    DEFF Research Database (Denmark)

    Nørgaard, Bent

    2007-01-01

    og ikke skader kroppens sunde celler. Metoden går ud på at indkapsle kræftmedicin i bittesmå fedtkugler, såkaldt "magiske kugler". I forestillingen følger vi de magiske kuglers fantastiske rejse: Lige fra deres spæde fødsel som en vision fremsat af den tyske nobelprisvinder dr. Paul Ehrlich i...

  3. Den gamle verdens magi

    DEFF Research Database (Denmark)

    Holck, Jakob Povl

    I denne bog præsenterer forskningsbibliotekar cand.mag., ph.d. Jakob Povl Holck sjældne bøger og andre biblioteksmaterialer fra Herlufsholm-samlingen på Syddansk Universitetsbibliotek i Odense. Bogens form udgør en mosaik af værker i tekst og især billeder med speciel vægt på ’den videnskabelige ...

  4. From genome-wide association studies to Mendelian randomization: Novel opportunities for understanding cardiovascular disease causality, pathogenesis, prevention, and treatment.

    Science.gov (United States)

    Benn, Marianne; Nordestgaard, Børge G

    2018-02-19

    The Mendelian randomization approach is an epidemiologic study design incorporating genetic information into traditional epidemiologic studies to infer causality of biomarkers, risk factors, or lifestyle factors on disease risk. Mendelian randomization studies often draw on novel information generated in genome-wide association studies on causal associations between genetic variants and a risk factor or lifestyle factor. Such information can then be used in a largely unconfounded study design free of reverse causation to understand if and how risk factors and lifestyle factors cause cardiovascular disease. If causation is demonstrated, an opportunity for prevention of disease is identified; importantly however, before prevention or treatment can be implemented, randomized intervention trials altering risk factor levels or improving deleterious lifestyle factors needs to document reductions in cardiovascular disease in a safe and side-effect sparse manner. Documentation of causality can also inform on potential drug targets, more likely to be successful than prior approaches often relying on animal or cell studies mainly.The present review summarizes the history and background of Mendelian randomization, the study design, assumptions for using the design, and the most common caveats, followed by a discussion on advantages and disadvantages of different types of Mendelian randomization studies using one or more samples and different levels of information on study participants. The review also provides an overview of results on many of the risk factors and lifestyle factors for cardiovascular disease examined to date using the Mendelian randomization study design.

  5. Den Gode Historie

    DEFF Research Database (Denmark)

    Mogensen, T.E.

    Historie er] begejstret oplysningsarbejde. [...] [D]et spændende nye er konkordansen mellem rum og menneskesyn, som her kan opleves i en illustreret ordbog. Sætter man en plade med Bachs cembalo-suiter med deres fuga- og kanonsystem på undervejs, får man måske en yderligere eller inderligere dimension...... sandhed får lov at stå uimodsagt. I romanernes tætte væv synes alt at være til stede og trænge sig på samtidig. Skal man skrive dækkende om et så stort, vildtvoksende og vidt forgrenet værk, tage højde for de mange krydsforbindelser og belyse dem, kræver det en ganske særlig form: den encyklopædiske. Den...... tilbydes en litterær lystvandring ud over det sædvanlige. Anmelderne skrev:  Man kunne sige, at Den Gode Historie er litteraturanalysens svar på internettet i det kjærstadske cyberspace. Men modsat internettets anarki er der her en benhård og kyndig styring af linkenes sammenhæng, og samtidig har bogen...

  6. Astrovirus Pathogenesis

    Directory of Open Access Journals (Sweden)

    Cydney Johnson

    2017-01-01

    Full Text Available Astroviruses are a major cause of diarrhea in the young, elderly, and the immunocompromised. Since the discovery of human astrovirus type 1 (HAstV-1 in 1975, the family Astroviridae has expanded to include two more human clades and numerous mammalian and avian-specific genotypes. Despite this, there is still little known about pathogenesis. The following review highlights the current knowledge of astrovirus pathogenesis, and outlines the critical steps needed to further astrovirus research, including the development of animal models of cell culture systems.

  7. Den Danske Netordbog

    DEFF Research Database (Denmark)

    Bergenholtz, Henning; Vrang, Vibeke; Almind, Richard

    Denne danske ordbog er primært tænkt som hjælpeværktøj i forbindelse med tvivl og usikkerhed, når man skriver en dansk tekst. Den Danske Netordbog er en yderst omfattende ordbog med mere end 110.000 forskellige opslagsord og en lang række oplysninger, herunder grammatik, betydning, synonym (ord med...... samme betydning), antonym (ord med modsat betydning), orddannelse (i hvilke andre ord det pågældende ord er en del af), kollokationer (ordforbindelser), idiomer (fast udtryk med en særlig betydning) og ordsprog og citater....

  8. Krisen i den Britiske Union

    DEFF Research Database (Denmark)

    2010-01-01

    at betale for skotsk, walisisk og nordirsk selvbestemmelse. De tre store britiske partier er først lige begyndt at forholde sig til den krise der er for den Britiske Union og hvad de har tænkt sig at gøre for at løse problemerne vil vi vende tilbage til her i Orientering i den kommende tid....

  9. Crowned dens syndrome

    Directory of Open Access Journals (Sweden)

    Norma Belfiore

    2012-10-01

    Full Text Available Introduction Microcrystalline deposition in peri-odontoid articular structures is mainly responsible for acute or chronic cervical pain and is known as “crowned dens syndrome”.Materials and methods We described two cases of acute cervical pain associated with onset of fever and peripheral acute monoarthritis. Cervical computed tomography (CT scan showed linear calcification of the retrodens ligament and calcium pyrophosphate dehydrate (CPPD crystals were found in synovial fluid of inflamed joints. Both patients were treated with anti-inflammatory drugs and colchicine.Discussion Calcium depositions around the odontoid process of the axis can be occasionally detected by radiological studies. They are frequently asymptomatic but sometimes can be associated with severe neurological abnormalities, fever and acute neck pain. CPPD crystals are usually deposited in joints and bursae but occasionally can disrupt these anatomical confines and deposit in periarticular tissues, sometimes forming large masses confused with tumours.Conclusions Acute onset of cervical neck pain associated with elevation of inflammatory indicators and/or signs of cervical myelopathy should suggest CT scans searching for microcrystal depositions in the peryodonthoid tissue. Differential diagnosis of fever of unknown origin (FUO should include crowned dens syndrome specially in the elderly after exclusion of several endocrine or metabolic disorders, infection diseases (meningitis, arthritis (psoriatic arthritis and ankylosing spondylitis and tumours (chordoma, meningioma, osteoblastoma.

  10. Sygehusene i den islamiske verden i den klassiske tid

    OpenAIRE

    Provencal, Philippe

    2014-01-01

    Et af de væsentlige punkter, hvor den arabiske medicin udmærker sig i forhold til tidligere tiders medicin var i oprettelsen og organiseringen af regelrette sygehuse. Artiklen beskriver sygehusenes oprindelse, plads og funktion i den klassiske arabiske kultur (750-1500)

  11. A rare presentation of bilateral maxillary dens invaginatus diagnosed using cone beam computed tomography.

    Science.gov (United States)

    Dinapadu, Sainath; Aravelli, Swathi; Pasari, Srikanth; Marukala, Narender Reddy

    2013-01-01

    Dens invaginatus is a developmental variation in the formation of a tooth that causes changes in the internal anatomy of the tooth. The presence of double dens invaginatus is extremely rare. Understanding the type, extension, and complex morphology of dens invaginatus is essential. Diagnosis of this condition using conventional radiographic techniques is not easy. Advanced imaging techniques, such as cone beam computed tomography (CBCT) are very helpful in diagnosis of these complex anatomic variations. In the present case report, we demonstrate the use of CBCT in the evaluation and treatment planning of bilateral maxillary dens invaginatus, of which one presented as a case of double dens.

  12. A Rare Presentation of Bilateral Maxillary Dens Invaginatus Diagnosed Using Cone Beam Computed Tomography

    Directory of Open Access Journals (Sweden)

    Sainath Dinapadu

    2013-01-01

    Full Text Available Dens invaginatus is a developmental variation in the formation of a tooth that causes changes in the internal anatomy of the tooth. The presence of double dens invaginatus is extremely rare. Understanding the type, extension, and complex morphology of dens invaginatus is essential. Diagnosis of this condition using conventional radiographic techniques is not easy. Advanced imaging techniques, such as cone beam computed tomography (CBCT are very helpful in diagnosis of these complex anatomic variations. In the present case report, we demonstrate the use of CBCT in the evaluation and treatment planning of bilateral maxillary dens invaginatus, of which one presented as a case of double dens.

  13. Den danske taxonliste for karplanter

    DEFF Research Database (Denmark)

    Wind, Peter

    2017-01-01

    Karplanternes navngivning og slægtskabsforhold har løbende ændret sig siden Linné (1707-1778) lagde grunden til den nomenklatur og systematik, som nutidens taksonomi bygger på. Han var samtidig fader til den toledede navngivning, dvs. at enhver levende organisme fik et ’latinsk’ slægts- og artsna...

  14. Velkommen til den posthumane tilstand

    DEFF Research Database (Denmark)

    Wamberg, Jacob

    2015-01-01

    Hvorfor er moderne kunst så insisterende mærkværdig? Fordi den udforsker en posthuman tilstand, som bliver stadig mere påtrængende.......Hvorfor er moderne kunst så insisterende mærkværdig? Fordi den udforsker en posthuman tilstand, som bliver stadig mere påtrængende....

  15. Hyldest til den destruktive feminist

    DEFF Research Database (Denmark)

    Hansen, Brian Benjamin

    2017-01-01

    Den destruktive feminist er kommet for at uddele røvfulde og slikkepinde – og hun er netop løbet tør for slikkepinde.......Den destruktive feminist er kommet for at uddele røvfulde og slikkepinde – og hun er netop løbet tør for slikkepinde....

  16. Litteratur i den argumentative ret

    DEFF Research Database (Denmark)

    Jørgensen, Stine

    2007-01-01

    Med udgangspunkt i den litterære rett, slik som denne er udviklet af den amerikanske retsfilosof Martha Nussbaum, argumentere de for, at litteraturen er velegnet som en metode til at opnå menneskelig forståelse. Som led i denne problemstillingen behandles følelsenes plads i retsvidenskaben. Endelig...

  17. Tidsrejse i den didaktiske Bermudatrekant

    DEFF Research Database (Denmark)

    Henriksen, Carsten

    2014-01-01

    Gudinden Athene var blandt de første, der praktiserede den: fagdidaktikken. Siden har den stolte disciplin overlevet mangen en elev og underviser. Tag med på en fagdidaktisk rejse, der kaster anker centrale steder i fagdidaktikkens historie fra Homer til folkeskolereform....

  18. Den naturlige tillid og tilknytning

    DEFF Research Database (Denmark)

    Bo, Inger Glavind

    2008-01-01

    Giddens og Johan Bowlbys forståelser af den fundamentale tillid eller sikker base kædes tilliden sammen med det spæde barns tilknytning til sine primære omsorgspersoner, da det er her fundamentet for senere tilknytningsadfærd og tillidsrelationer etableres som en integreret del af den naturlige...

  19. Stordriftsfordele i den danske banksektor?

    DEFF Research Database (Denmark)

    Kristensen, Troels

    2008-01-01

    Dette er en empirisk undersøgelse af skalaegenskaber (economies of scale) i den danske banksektor baseret på cross-section data. Banksektorens omkostningsfunktion er estimeret vha. en translogomkostningsfunktion og OLS-regression. Ud fra den estimerede omkostningsfunktion er skalaegenskaberne...

  20. Tillid i den finansielle sektor

    DEFF Research Database (Denmark)

    Rimmer, Nina Røhr; Nielsen, Sara Møller; Benediktsdottir, Elisabet

    2014-01-01

    lønsomhed. Konklusionerne er opsamlet i 2 analysedele, den første med fire overskrifter: Tillid, Medie & politisk indflydelse, Forholdet mellem kunden og rådgiveren samt Kommunikation – og den anden i en SWOT model. Nogle af hovedkonklusionerne er, at kunderne ikke har mistet tillid til hverken deres...

  1. Den medicinal-industrielle logik

    DEFF Research Database (Denmark)

    Børsen, Tom

    2008-01-01

    Et kig på medicinalindustrien og den logik der styrer udviklingen af nye lægemidler. Antagelsen er, at der også eksisterer et medicinalindustrielt kompleks, bestående af ledende industrifolk, læger, forskere og regeringsembedsmænd, der alle har kommercielle interesser i den herskende lægemiddeltæ...

  2. Dorte Nors "Den store tomat"

    DEFF Research Database (Denmark)

    Michelsen, Jimmi

    2017-01-01

    Tekstgennemgang og undervisningsforløb til Dorte Nors "Den store tomat". Undervisningsforløbet er henvendt til elever i folkeskolens udskoling......Tekstgennemgang og undervisningsforløb til Dorte Nors "Den store tomat". Undervisningsforløbet er henvendt til elever i folkeskolens udskoling...

  3. Dens invaginatus (Type III B).

    Science.gov (United States)

    Kallianpur, Shreenivas; Sudheendra, Us; Kasetty, Sowmya; Joshi, Prathamesh

    2012-05-01

    Dens invaginatus or 'dens in dente' is a developmental malformation of the tooth resulting from infolding of the dental papilla before calcification. This article presents a case of dens invaginatus occurring in maxillary right lateral incisor of a 45-year-old male patient. The patient presented with pain and clinically missing maxillary right canine. The tooth was found to be non-vital. Radiographic examination revealed the tooth-in-tooth appearance of lateral incisor with a dilated pulp chamber. The crown of impacted canine was found within the pulp chamber of lateral incisor. Owing to this unique clinical presentation, both the lateral incisor and the impacted canine were extracted. Histopathologic examination confirmed the diagnosis of Dens invaginatus Type III B. A brief review on etiopathogenesis, radiographic features and treatment of dens invaginatus has also been included.

  4. Den narrative tilgang

    DEFF Research Database (Denmark)

    Bo, Inger Glavind

    2016-01-01

    I kapitlet gennemgås en socialkonstruktivistisk forståelse af narrativer. I kapitlet vil jeg gennemgå centrale teoretiske pointer, der samlet set er grundlæggende for en social konstruktivistisk forståelse af narrativer for herved at udfolde forståelsen af den narrative tilgang og desuden...... tydeliggøre, hvordan tilgangen er forbundet med en særlig forståelse af identitetsskabelse. Der er tale om pointer der almindeligvis forbindes med ”små fortællinger” i form af længere identitetsfortællinger og narrative interviews. Kapitlet gennemgår således centrale inspirationskilder og teoretiske pointer...

  5. Den kolde videnskab og den varme omsorg

    DEFF Research Database (Denmark)

    Højlund, Susanne

    1996-01-01

    This essay focusses on the cultural understanding of the nursing profession as a practice of contrasts. The criticism of dualism put forward by Gregory Bateson is presented and discussed in relation to the thinking of Kari Martinsen. Bateson's ideas about 'third position' and 'interface' are used...

  6. Challenges and issues with streptozotocin-induced diabetes - A clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics.

    Science.gov (United States)

    Goyal, Sameer N; Reddy, Navya M; Patil, Kalpesh R; Nakhate, Kartik T; Ojha, Shreesh; Patil, Chandragouda R; Agrawal, Yogeeta O

    2016-01-25

    Streptozotocin (STZ) has been extensively used over the last three decades to induce diabetes in various animal species and to help screen for hypoglycemic drugs. STZ induces clinical features in animals that resemble those associated with diabetes in humans. For this reason STZ treated animals have been used to study diabetogenic mechanisms and for preclinical evaluation of novel antidiabetic therapies. However, the physiochemical characteristics and associated toxicities of STZ are still major obstacles for researchers using STZ treated animals to investigate diabetes. Another major challenges in STZ-induced diabetes are sustaining uniformity, suitability, reproducibility and induction of diabetes with minimal animal lethality. Lack of appropriate use of STZ was found to be associated with increased mortality and animal suffering. During STZ use in animals, attention should be paid to several factors such as method of preparation of STZ, stability, suitable dose, route of administration, diet regimen, animal species with respect to age, body weight, gender and the target blood glucose level used to represent hyperglycemia. Therefore, protocol for STZ-induced diabetes in experimental animals must be meticulously planned. This review highlights specific skills and strategies involved in the execution of STZ-induced diabetes model. The present review aims to provide insight into diabetogenic mechanisms of STZ, specific toxicity of STZ with its significance and factors responsible for variations in diabetogenic effects of STZ. Further this review also addresses ways to minimize STZ-induced mortality, suggests methods to improve STZ-based experimental models and best utilize them for experimental studies purported to understand diabetes pathogenesis and preclinical evaluation of drugs. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  7. Den iscenesatte folkelighed

    Directory of Open Access Journals (Sweden)

    Néstor Garcia Canclini

    1994-09-01

    Full Text Available Hvad er "det folkelige" og hvad er "folkekultur"? Néstor Garcia Canclini har i denne artikel sat sig for at dekonstruere begrebet "det folkelige" og beskrive den måde, forskellige grupper bruger og misbruger begrebet på. Han analyserer tre fremherskende idéer om folkelighed: folkloristernes romantiske idé om det oprindelige, der blev ødelagt af massekulturen, massemediernes popularitetsbegreb og endelig populisternes - både de højre- og venstreorienteredes - iscenesættelse af folkeligheden. Desuden ser han på to marxistiske skolers opfattelse af forholdet mellem de dominerende og undertrykte klasser og forskellige definitioner af folkelig- hed. Ligesom Anamaria Fadul argumenterer Canclini for nødvendigheden af en ny, tværdiciplinær forskning, som opfanger kompleksitet og flerty- digheder i forholdet mellem de undertrykte og dominerende og ser "det folkelige" som en tragisk komedie med modsætninger og flertydighed snarere end en evigt fremadskrivende episk fortælling. Artiklen er en forkortet udgave af kapitel 5 i Canclinis bog fra 1989: "Culturas Hibridas - Estrategias para entrat y salir de la modernidad. Mexico: Grijalbo.

  8. Den Blå Drage

    DEFF Research Database (Denmark)

    Ingerslev, Gitte Holten

    Denne publikation i serien Læselyst tjener tre formål. Den evaluerer læseprojektet Den blå drage i efteråret 2004 på Byskolen i Svendborg ? et projekt ledet af forfatteren Josefine Ottesen. Desuden gøres der rede for nogle af de teorier der støtter og begrunder arbejdsmåde og resultater i projektet...

  9. Events i den globale bykonkurrence

    DEFF Research Database (Denmark)

    Østergaard, Katrine

    2005-01-01

    Paper til ph.d. workshop, d. 9. december 2005. Dette paper beskriver, hvorfor og hvordan events kan bruges som strategi for byplanlægning og byudvikling i den globale bykonkurrence.......Paper til ph.d. workshop, d. 9. december 2005. Dette paper beskriver, hvorfor og hvordan events kan bruges som strategi for byplanlægning og byudvikling i den globale bykonkurrence....

  10. Den tidslogiske analyse af determinismeproblemet

    DEFF Research Database (Denmark)

    Øhrstrøm, Peter

    2010-01-01

    Artiklen diskuterer den filosofiske tidslogik med særligt henblik på A.N. Priors bidrag hertil. Det logiske determinismeproblem benyttes som gennemgående eksempel. Det vises endvidere, hvordan tidslogikken kan udnyttes til at analysere de logisk mulige positioner i en videnskabelig eller videnska...... videnskabsteoretisk debat. Her bruges den videnskabshistorisk betydende diskussion mellem Charles Darwin og Asa Gray som eksempel....

  11. Den litterære blog

    DEFF Research Database (Denmark)

    Serup, Martin Glaz; Kromann, Thomas Hvid

    2012-01-01

    Hvad er en litterær blog og hvordan arbejder den som en aktiv del af den litterære offentlighed.......Hvad er en litterær blog og hvordan arbejder den som en aktiv del af den litterære offentlighed....

  12. Understanding the Function of Genes Involved in Inherited Retinal Degeneration-Insights into the Pathogenesis and Function of C8ORF37

    Science.gov (United States)

    Sharif, Ali Sakawa

    Inherited retinal degenerative diseases (IRD) are a group of disorders that lead to progressive deterioration of mainly the photoreceptors. Retinitis pigmentosa (RP) and cone-rod dystrophy (CRD) are two forms of IRDs. RP is the most common form of IRD and is due to rod photoreceptor degeneration followed by cone photoreceptor loss. CRD, on the other hand, is characterized by the loss of cones or the concurrent degeneration of both cones and rods. Both RP and CRD are presently incurable. More than 200 genes have been identified to cause IRDs and the functions of many of these genes remain unclear. Mutations in a novel gene, C8ORF37, were identified to cause recessive, severe, and early-onset RP and CRD. I, therefore, pioneered in characterizing the role of C8ORF37 in the retina. This dissertation is comprised of four chapters that is organized as follows: (1) summary of an ocular disorder (2) a genetic model of a retinal disorder (3) biochemical/proteomic analysis of C8ORF37 (4) potential clinical applications. A summary of ocular disorders is discussed in Chapter 1, with an emphasis on CRD. Chapter 2 focuses on the generation and characterization of C8orf37 mutant mouse models that recapitulate the retinal pathologies observed in human patients. In C8orf37 knockout retinas, the outer segment (OS) was nonuniform, swollen, and wider in width when compared to the controls. Moreover, many OS membrane proteins were reduced in the retina of C8orf37 knockout, including CNGB1 and RDS, proteins essential for OS disc morphogenesis and alignment. Our findings shed new light on the pathogenesis underlying retinal dysfunction and degeneration in C8ORF37-deficient patients. To determine the function of a novel protein, a powerful approach is by identifying its binding partners. In Chapter 3, I discuss GST pull-down using bovine retinal lysates, yeast-two-hybrid, and immunoprecipitation with mouse retinal lysate in order to identify C8ORF37-interacting proteins. Our pull

  13. Double Dens Invaginatus: Report of Three Cases

    OpenAIRE

    Zengin, A. Zeynep; Sumer, A. Pinar; Celenk, Peruze

    2009-01-01

    Dens invaginatus results from an infolding of the outer surface of a tooth. The clinical importance of dens invaginatus results from the risk of pulpal disease. So, all clinicians should be aware of this anomaly. The presence of double dens invaginatus is extremely rare. This article presents three cases of double dens invaginatus in permanent maxillary lateral incisors, one with preventive restoration on its palatal surface. They were classified as double dens invaginatus because of two enam...

  14. The Pathogenesis of Autism

    Directory of Open Access Journals (Sweden)

    Timothy John Watts

    2008-01-01

    Full Text Available Autism is well known as a complex developmental disorder with a seemingly confusing and uncertain pathogenesis. The definitive mechanisms that promote autism are poorly understood and mostly unknown, yet available theories do appear to focus on the disruption of normal cerebral development and its subsequent implications on the functional brain unit. This mini-review aims solely to discuss and evaluate the most prominent current theories regarding the pathogenesis of autism. The main conclusion is that although there is not a clear pathway of mechanisms directed towards a simple pathogenesis and an established link to autism on the symptomatic level; there are however several important theories (neural connectivity, neural migration, excitatory-inhibitory neural activity, dendritic morphology, neuroimmune; calcium signalling and mirror neurone which appear to offer an explanation to how autism develops. It seems probable that autism's neurodevelopmental defect is ‘multi-domain’ in origin (rather than a single anomaly and is hence distributed across numerous levels of study (genetic, immunopathogenic, etc.. A more definitive understanding of the pathogenesis could facilitate the development of better treatments for this complex psychiatric disorder.

  15. Von den Veranschaulichungsmethoden in den Rundfunkpredigten von der Heiligkreuz- Kirche

    Directory of Open Access Journals (Sweden)

    Witold Ostafiński

    2004-12-01

    Full Text Available In der gegenwärtigen Verkündigung des Wortes Gottes spielt die Veranschaulichung der Überlieferung eine nicht zu überschätzende Rolle. Vor diesem Hintergrund wird es sehr wichtig, dass man den Predigern nicht nur auf die Funktion des Bildes in der Verkündigung, sondern auch auf die Art und Weise seines Entstehens auf der narrativen Ebene aufmerksam macht. Während die Kenner der Homiletik die Notwendigkeit des Auftretens der Bildeigenschaften in den Predigten betonen, erinnern sie gleichzeitig daran, dass der moderne, von der „Bild-Zivilisation“ gestaltete Mensch, „immer mehr sehen als hören“ möchte. Der vorliegende, die Rundfunkpredigten von der Heiligkreuz-Kirche analysierende Aufsatz, nimmt auf und bringt zugleich nahe die Problematik der Notwendigkeit des Bildes in der Wort-Gottes-Verkündigung. Der Artikel stellt die Erzählungsform als eine wichtige Möglichkeit der Glaubensüberlieferung dar, behandelt das Problem der Aktualisierung evangelischen Werte, bringt das von den Predigten gestaltete synästhetische Weltbild nahe und analysiert die Rolle des Zitats und Beispiels (exemplum bei der Gestaltung der Bildhaftigkeit einer Predigt. Darüber hinaus überprüft der Aufsatz in seinem letzten Teil die in den gegenwärtigen Rundfunkpredigten meist verwendeten Redefiguren

  16. Publikum svinger den retoriske taktstok

    DEFF Research Database (Denmark)

    Hansen, Jette Barnholdt

    2012-01-01

    Artiklen handler om revyvisen "Man binder os på mund og hånd" af Poul Henningensen med musik af Kai Normann Andersen, som oprindeligt var en del af den kulturradikale revykomedie Dyveke fra 1940, der bla. advokerede for seksuel frigørelse. Visen levede dog hurtigt sit eget liv uden for revyteatret...

  17. Multikultureller Wohnungsbau in den Niederlanden

    NARCIS (Netherlands)

    Meier, S.

    2012-01-01

    In den Niederlanden sind Immigranten längst eine Zielgruppe auf dem Wohnungsmarkt. Architekten und Wohnungsbaugesellschaften haben, so scheint es, zunehmend weniger Berührungsängste gegenüber nicht-westlichen Bautraditionen. Wohnanlagen wie „Le Medi" und „De Oriënt" könnten Modelle sein für die

  18. Multikultureller Wohnungsbau in den Niederlanden

    NARCIS (Netherlands)

    dr.ir. Sabine Meier

    2012-01-01

    In den Niederlanden sind Immigranten längst eine Zielgruppe auf dem Wohnungsmarkt. Architekten und Wohnungsbaugesellschaften haben, so scheint es, zunehmend weniger Berührungsängste gegenüber nicht-westlichen Bautraditionen. Wohnanlagen wie „Le Medi“ und „De Oriënt“ könnten Modelle sein für die

  19. Etikken i den maskerede by

    DEFF Research Database (Denmark)

    Liebst, Lasse Suonperä

    2009-01-01

    Artiklen problematiserer Zygmunt Baumans argument om, at æstetiseringen iden postmoderne by er uforenelig med en virksom etisk ansvarlighed for denfremmede i byen. Denne forståelse er kraftigt inspireret af Emmanuel Lévinas’fænomenologiske nærhedsetik, der forstår æstetik og etik som...... antagonistiskefænomener. Med afsæt i denne forståelse anser Bauman æstetiseringen af denAnden, som en maskering af det nøgne ansigt, der ifølge Lévinas er den etiskefordrings kilde. Hermed mødes den Anden ikke som et unikt menneske, mensnarere som et overfladisk objekt, der nydes uden etisk ansvar. Artiklen pegerpå......, at Knud E. Løgstrups fænomenologiske nærhedsetik – som Bauman fejlagtigtjævnfører med Levinas’ – tilbyder en interessant alternativ forståelse af forholdetimellem æstetik og etik: Ifølge Løgstrup har æstetikken nemlig forrang foretikken. Artiklens afgørende argument bliver i lyset heraf, at den etiske...

  20. Amerikansk sikkerhedspolitik efter den kolde krig

    DEFF Research Database (Denmark)

    Pall Skött, Jakob; Nielsen Kjær, Anna

    2005-01-01

    Via en Foucaldiansk analyseramme vil artiklen demonstrere et skift i den amerikanske sikkerhedsdiskurs. Derefter vil den fremhæve de nye kontrollerend emagtlogikkers paradoksale konsekvenser for den krig mod terror, der udkæmpes i frihedens og demokratiets navn. Udgivelsesdato: Marts...

  1. Den sociale stofmisbrugsbehandling. Del 1

    DEFF Research Database (Denmark)

    Heltberg, Therese

    Denne rapport er den første delrapport i en undersøgelse af den sociale stofmisbrugsbehandling i Danmark, som SFI har gennemført for Servicestyrelsen i perioden december 2007 til maj 2009. Undersøgelsen omhandler den sociale stofmisbrugsbehandling efter § 101 i Serviceloven, mens undersøgelsen i ...

  2. Double dens invaginatus: report of three cases.

    Science.gov (United States)

    Zengin, A Zeynep; Sumer, A Pinar; Celenk, Peruze

    2009-01-01

    Dens invaginatus results from an infolding of the outer surface of a tooth. The clinical importance of dens invaginatus results from the risk of pulpal disease. So, all clinicians should be aware of this anomaly. The presence of double dens invaginatus is extremely rare. This article presents three cases of double dens invaginatus in permanent maxillary lateral incisors, one with preventive restoration on its palatal surface. They were classified as double dens invaginatus because of two enamel lined invaginations presented in the crowns of these teeth.

  3. Den kulturelle dimension af virksomhedens internationalisering

    DEFF Research Database (Denmark)

    Langhoff, Tine

    1994-01-01

    Artiklen omhandler den kulturelle dimensions indvirkning på virksomhedens internationalisering og diskuterer mulige internationalisieringsstrategier for virksomheder, der konfronteres med kulturforskelle. Med udgangspunkt i en kritik af den hidtidige forskning på området, hvor det såkaldte psykiske...... distancebegreb har haft en central placering, foreslås det, at man som alternativ til dette begreb skal fokusere på virksomhedens markedsbaserede innovationsevne. Denne betegnes som dens interkultu kompetence og vedrører dens evne til at identificere og udnytte muligheder i fremmede kulturelle sammenhænge. Det...... er herved, at den kulturelle dimension påvirker virksomheden og dens fortsatte udvikling. En empirisk analyse i den danske fødevarebranche afdækker virksomheders interkulturelle kompetence ved hjælp af to spørgsmål: (1) Hvorledes formår virksomheder med begrænsede ressourcer til deres disposition...

  4. Kritik av den negativa uppbyggligheten

    DEFF Research Database (Denmark)

    Stjernfelt, Frederik; Thomsen, Søren Ulrik

    Under efterkrigstiden har ett märkligt fenomen fått fäste i kulturen. Ett konstverk, en handling, en utsaga bedöms inte längre efter om de är sköna, goda och sanna, utan efter om de bryter mot regler, gör uppror mot det konventionella eller angriper etablerade tänkesätt. Överskridandet av normer...... och provokationen mot inrotade uppfattningar framställs som viktigare än de positiva resultaten, avståndstagandet viktigare än ställningstagandet. Från att ha varit idéer hos ett fåtal filosofer, konstnärer och bohemer har denna negativism efterhand blivit en ideologi för den breda massan. Den...

  5. Campaign finance in den USA

    OpenAIRE

    Filzmaier, Peter; Plasser, Fritz

    2002-01-01

    'Die USA stellen einen exemplarischen Fall für exponentiell steigende Wahlkampfausgaben, fragwürdige Finanzierungspraktiken und ein de facto kollabiertes Regelungssystem dar. Anhand der aktuellen Diskussion um die Wahlkampffinanzierung werden drei Problemperspektiven angesprochen: Erstens geht es um die Erforschung der Ursachen des steigenden Kapitalbedarfs kompetitiver Wahlkämpfe in den USA als Musterbeispiel einer Teledemokratie. Aus demokratietheoretischer Sicht zu diskutieren sind zweiten...

  6. Pathogenesis of microbial keratitis.

    Science.gov (United States)

    Lakhundi, Sahreena; Siddiqui, Ruqaiyyah; Khan, Naveed Ahmed

    2017-03-01

    Microbial keratitis is a sight-threatening ocular infection caused by bacteria, fungi, and protist pathogens. Epithelial defects and injuries are key predisposing factors making the eye susceptible to corneal pathogens. Among bacterial pathogens, the most common agents responsible for keratitis include Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumonia and Serratia species. Fungal agents of corneal infections include both filamentous as well as yeast, including Fusarium, Aspergillus, Phaeohyphomycetes, Curvularia, Paecilomyces, Scedosporium and Candida species, while in protists, Acanthamoeba spp. are responsible for causing ocular disease. Clinical features include redness, pain, tearing, blur vision and inflammation but symptoms vary depending on the causative agent. The underlying molecular mechanisms associated with microbial pathogenesis include virulence factors as well as the host factors that aid in the progression of keratitis, resulting in damage to the ocular tissue. The treatment therefore should focus not only on the elimination of the culprit but also on the neutralization of virulence factors to minimize the damage, in addition to repairing the damaged tissue. A complete understanding of the pathogenesis of microbial keratitis will lead to the rational development of therapeutic interventions. This is a timely review of our current understanding of the advances made in this field in a comprehensible manner. Coupled with the recently available genome sequence information and high throughput genomics technology, and the availability of innovative approaches, this will stimulate interest in this field. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Konsulenten i den anden nat

    DEFF Research Database (Denmark)

    Kirkegaard, Line

    for i sit deres liv og den eksistensmåde, der hermed muliggøres. Med dette ønsker jeg at bidrage til de eksisterende work-life balance teorier. Min vej ind i teorierne er nemlig, at logikken i mit empiriske materiale forekommer så forskelligt fra de traditionelle work-life balance teorier, at disse ikke...... lader sig forene. Jeg foretage derfor en analyse af den eksisterende litteratur, og rejser i den forbindelse en grundlæggende kritik af work-life balance teorierne, for at operere med falske problemstillinger på en måde, så svaret allerede indgår i de spørgsmål, der stilles. Jeg argumenterer således for......, at det problematiske forhold ved work-life balance teorierne allerede skal søges i konstitueringen af deres problematik, hvor arbejde og fritid indgår som to distinkte og kontrasterende sfærer. Ubalance eller problemer søges således altid i relationen her imellem. I forlængelse heraf argumenterer jeg for...

  8. Identification of a dengue virus type 2 (DEN-2) serotype-specific B-cell epitope and detection of DEN-2-immunized animal serum samples using an epitope-based peptide antigen.

    Science.gov (United States)

    Wu, Han-Chung; Jung, Mei-Ying; Chiu, Chien-Yu; Chao, Ting-Ting; Lai, Szu-Chia; Jan, Jia-Tsrong; Shaio, Men-Fang

    2003-10-01

    In this study, a serotype-specific monoclonal antibody (mAb), D(2) 16-1 (Ab4), against dengue virus type 2 (DEN-2) was generated. The specificity of Ab4, which recognized DEN-2 non-structural protein 1, was determined by ELISA, immunofluorescence and immunoblotting analyses. The serotype-specific B-cell epitope of Ab4 was identified further from a random phage-displayed peptide library; selected phage clones reacted specifically with Ab4 and did not react with other mAbs. Immunopositive phage clones displayed a consensus motif, His-Arg/Lys-Leu/Ile, and a synthetic peptide corresponding to the phage-displayed peptide bound specifically to Ab4. The His and Arg residues in this epitope were found to be crucial for peptide binding to Ab4 and binding activity decreased dramatically when these residues were changed to Leu. The epitope-based synthetic peptide not only identified serum samples from DEN-2-immunized mice and rabbits by ELISA but also differentiated clearly between serum samples from DEN-2- and Japanese encephalitis virus-immunized mice. This mAb and its epitope-based peptide antigen will be useful for serologic diagnosis of DEN-2 infection. Furthermore, DEN-2 epitope identification makes it feasible to dissect antibody responses to DEN and to address the role of antibodies in the pathogenesis of primary and secondary DEN-2 infections.

  9. Den anden gæld

    DEFF Research Database (Denmark)

    Agustin, Lise Rolandsen

    2003-01-01

    I-landene har akkumuleret en økologisk gæld til u-landene som langt overstiger udlandsgælden. Den skal kompensere for udnyttelsen af naturressourcerne og den miljømæssige forurening, der er fulgt i kølvandet på udvindingen og eksporten af råvarer fra Syd til Nord. Den økologiske gæld fokuserer gl...

  10. den som foruroligende beroligelse

    DEFF Research Database (Denmark)

    Hansen, Ejvind

    2005-01-01

    Det giver mening at tale om, at dødenden ene side er noget af det vi er allermest sikre på – fordi vi ved at vi skal dø. Vi er faktisk så sikre på det, at vi kan bygge et samfund og en kultur op omkring denne vished. Man kan altså sige, at der er noget beroligende ved døden. Men kulturernes f...

  11. Huntington disease: pathogenesis and treatment.

    Science.gov (United States)

    Dayalu, Praveen; Albin, Roger L

    2015-02-01

    Huntington disease (HD) is an autosomal dominant inherited neurodegenerative disease characterized by progressive motor, behavioral, and cognitive decline, culminating in death. It is caused by an expanded CAG repeat in the huntingtin gene. Even years before symptoms become overt, mutation carriers show subtle but progressive striatal and cerebral white matter atrophy by volumetric MRI. Although there is currently no direct treatment of HD, management options are available for several symptoms. A better understanding of HD pathogenesis, and more sophisticated clinical trials using newer biomarkers, may lead to meaningful treatments. This article reviews the current knowledge of HD pathogenesis and treatment. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. Dens evaginatus and dens invaginatus in all maxillary incisors: report of a case.

    Science.gov (United States)

    Vardhan, Talla Harsha; Shanmugam, Subramanyam

    2010-02-01

    Dens evaginatus is a developmental malformation characterized by the presence of an extra cusp that takes the form of a tubercle arising from the occlusal or the lingual surface of the tooth. It is also referred to as talon cusp in the anterior teeth and Leong premolar in the premolars. Dens invaginatus is a deep surface invagination of the crown or the root lined by enamel, dentin, and pulp. Though many case reports of dens evaginatus and dens invaginatus have been found in the literature, an association of both is a rare anomaly. Only two cases of concomitance of dens invaginatus and dens evaginatus have been reported. This article is a case report of dens evaginatus and dens invaginatus involving all four maxillary incisors in a 25-year-old patient.

  13. Molecular Pathogenesis of NASH

    Directory of Open Access Journals (Sweden)

    Alessandra Caligiuri

    2016-09-01

    Full Text Available Nonalcoholic steatohepatitis (NASH is the main cause of chronic liver disease in the Western world and a major health problem, owing to its close association with obesity, diabetes, and the metabolic syndrome. NASH progression results from numerous events originating within the liver, as well as from signals derived from the adipose tissue and the gastrointestinal tract. In a fraction of NASH patients, disease may progress, eventually leading to advanced fibrosis, cirrhosis and hepatocellular carcinoma. Understanding the mechanisms leading to NASH and its evolution to cirrhosis is critical to identifying effective approaches for the treatment of this condition. In this review, we focus on some of the most recent data reported on the pathogenesis of NASH and its fibrogenic progression, highlighting potential targets for treatment or identification of biomarkers of disease progression.

  14. Pathogenesis of Takotsubo syndrome

    Directory of Open Access Journals (Sweden)

    Daniele Masarone

    2017-01-01

    Full Text Available Takotsubo syndrome (TTS is an enigmatic disease with a multifactorial and still unresolved pathogenesis. Postulated mechanisms include catecholamine excess, coronary artery spasm, and microvascular dysfunction, however catecholamines seem to play a central role in the pathophysiology of TTS. In facts catecholamines have relevant effects on the vasculature and myocardium. Toxic direct effects of catecholamine on myocardium are mediated by multiple pathway including functional hypoxia, metabolic changes and changes in membrane permeability leading to various electrolytic imbalances. Recently report of familial cases has suggested a genetic component. Further research is required to help clarify the proposed hypotheses and to increase our understanding of the cardiovascular responses to acute stress and the pathophysiology underpinning TTS.

  15. Forever Young - den norske tv-serie Skam

    DEFF Research Database (Denmark)

    Jerslev, Anne

    2016-01-01

    Hvorfor er det lige, at den norske netbaserede ungdomsserie "Skam" er på alles læber for tiden? Svaret er simpelt: Den er nyskabende og supergod, og den taler til en langt bredere målgruppe end den gruppe af teenagepiger, den er rettet mod....

  16. Die grossen Physiker und ihre Entdeckungen von den fallenden Körpern zu den Quarks

    CERN Document Server

    Segrè, Emilio

    1998-01-01

    Von Galileo Galilei bis zu Richard Feynman und Murray Gell-Mann - von den fallenden Körpern zu den Quarks: Der Physiknobelpreisträger Emilio Segre hat seine ganz persönliche Geschichte der Physik geschrieben. Er erzählt von den großen Gestalten und deren wichtigen Entdeckungen mit großer Anschaulichkeit und Lebendigkeit.

  17. A Biochemical Approach to Understand the Pathogenesis of Advanced Pulmonary Arterial Hypertension: Metabolomic Profiles of Arginine, Sphingosine-1-Phosphate, and Heme of Human Lung.

    Directory of Open Access Journals (Sweden)

    Yidan D Zhao

    Full Text Available Pulmonary arterial hypertension (PAH is a vascular disease characterized by persistent precapillary pulmonary hypertension (PH, leading to progressive right heart failure and premature death. The pathological mechanisms underlying this condition remain elusive. Analysis of global metabolomics from lung tissue of patients with PAH (n = 8 and control lung tissue (n = 8 leads to a better understanding of disease progression. Using a combination of high-throughput liquid-and-gas-chromatography-based mass spectrometry, we showed unbiased metabolomic profiles of disrupted arginine pathways with increased Nitric oxide (NO and decreased arginine. Our results also showed specific metabolic pathways and genetic profiles with increased Sphingosine-1-phosphate (S1P metabolites as well as increased Heme metabolites with altered oxidative pathways in the advanced stage of the human PAH lung. The results suggest that PAH has specific metabolic pathways contributing to the vascular remodeling in severe pulmonary hypertension. Profiling metabolomic alterations of the PAH lung has provided a new understanding of the pathogenic mechanisms of PAH, which benefits therapeutic targeting to specific metabolic pathways involved in the progression of PAH.

  18. Cornelis den Hartog: an outstanding aquatic ecologist

    NARCIS (Netherlands)

    Velde, van der G.; Brock, T.C.M.; Kempers, A.J.

    1996-01-01

    A survey is given of the work and life of Cornelis den Hartog up to the date in 1996 on which he retired from his position as a professor at the University of Nijmegen. Cornelis (Kees) den Hartog made important contributions to aquatic ecology in the widest sense, e.G. On brackish water typology,

  19. Den filosofiske præstation

    DEFF Research Database (Denmark)

    Skytte Gørtz, Kim Erik

    Bogen gør op med forestillingen om, at filosoffen er uanvendelig i erhvervslivet. Den udfolder en erhvervsfilosofi og inddrager filosoffer som Kant, Hegel, Kierkegaard, Nietzsche, Heidegger og Deleuze......Bogen gør op med forestillingen om, at filosoffen er uanvendelig i erhvervslivet. Den udfolder en erhvervsfilosofi og inddrager filosoffer som Kant, Hegel, Kierkegaard, Nietzsche, Heidegger og Deleuze...

  20. Den barokke lov i Kafkas "Processen"

    DEFF Research Database (Denmark)

    Simonsen, Karen-Margrethe

    2011-01-01

    Artiklen diskuterer barokke aspekter af loven hos Kafka, idet den inddrager erkendelser fra den historiske barok, blandt andet dobbeltheden af labyrintisk ornamentik og vertikal magt, og inddrager diskussioner af hhv. Gilles Deleuzes, Jacques Derridas og Tzvetan Todorovs læsninger af Kafka....

  1. Jagten på den kloge globaliseringsstrategi

    DEFF Research Database (Denmark)

    Mehlsen, Camilla

    2004-01-01

    Den kloge globaliseringsstrategi har fået et navn: Livslang læring. Men er strategien klog, når den fører til et polariseret arbejdsmarked? Og hvem skal betale for at dygtiggøre folk gennem hele livet? Asterisk har talt med professor Andy Green fra University of London. Udgivelsesdato: December...

  2. Luftstaub über den Meeren

    DEFF Research Database (Denmark)

    Kacunko, Slavko; Kacunko, Sabine; Gorbushina, Ana

    2013-01-01

    Staub umgibt uns überall und alles wird auch irgendwann zu Staub - ob wir wollen oder nicht. Staub nicht nur zu bekämpfen, sondern zu untersuchen, bildet den Ausgangspunkt zahlreicher Forschungen in den Natur-, Ingenieur- und Kulturwissenschaften. Der vorliegende Band verbindet solche Beiträge au...

  3. Nyliberalisme, universiteter og den akademiske frihed

    DEFF Research Database (Denmark)

    Madsen, Mogens Ove

    2012-01-01

    Akademisk frihed er uløseligt forbundet med det, der er selve universitetets væsen. New Public Management er dog sevet ind i den offentlige forvaltning og kapitlet giver et signalement af, hvilke konsekvenser dette har haft for universiteterne og den akademiske frihed...

  4. Den sociale vending = velfærdsskepsis?

    DEFF Research Database (Denmark)

    Skiveren, Tobias

    2017-01-01

    Anmeldelse af Tue Andersen Nexø: "Vidnesbyrd fra velfærdsstaten. Den sociale vending i ny dansk litteratur". København 2016: Arena......Anmeldelse af Tue Andersen Nexø: "Vidnesbyrd fra velfærdsstaten. Den sociale vending i ny dansk litteratur". København 2016: Arena...

  5. Diagnosis and management of a maxillary lateral incisor exhibiting dens invaginatus and dens evaginatus.

    Science.gov (United States)

    Akers, Harry Francis; Henderson, Carolyn Mary; Foley, Michael Anthony

    2014-04-01

    This case report, involving an indigenous Australian, presents the diagnosis and non-surgical endodontic management of a 22 with developmental abnormalities. They include a dens evaginatus and a dens invaginatus that extends to an apical burst in a second truncated root. Cone-beam computed tomography and endodontic microscopy were not available to the clinician. This case report focuses on ambiguities appearing in the literature relating to classification and terminology associated with the abovementioned developmental anomalies. It also demonstrates the need to methodically collect and cautiously interpret available information before initiating endodontic intervention. Axial inclination, distance perception, internal demarcation and spatial awareness, together with an understanding of dental anatomy, embryology and histology and associated physiology and pathology, allowed the clinician to accurately predict the point, the angle and the depth of coronal access. Sensibility of the dentino-pulpal complex was maintained. Critical thinking, experience, innovation, problem-solving and established principles can compensate for inaccessible technologies. © 2014 Australian Society of Endodontology.

  6. Pathogenesis and biology.

    Science.gov (United States)

    Winkler, Frank

    2018-01-01

    Metastasis to the brain is an increasing complication of solid cancers. Fortunately, our understanding of its pathogenesis has greatly increased in the last decade, with crucial insights into the molecular and cellular determinants of successful brain colonization; some aspects remain less well understood. The latter include the exact features of brain metastasis-initiating cancer cells, and a potential premetastatic niche. It is clear that a brain-arrested cancer cell has to master a sequence of steps to eventually grow to a clinically relevant brain metastasis. Various brain-specific cell types and molecular niches promote or hinder brain colonization in a dynamic and reciprocal manner. After mandatory extravasation and colonization of a brain-specific perivascular niche, the cancer cell can stay dormant, or further grow by dynamic interactions with cerebral blood vessels. In addition, the activation of certain molecular pathways on site of the cancer cell which are related to growth, motility, survival, and adaptation to the brain environment appears also important, given their characteristic modification in brain metastases of patients. A deeper understanding of the most vulnerable steps of the brain metastatic cascade may foster the development of novel preventive approaches, and that of core biologic mechanisms for macrometastatic growth and persistence will help to develop better therapeutics. Copyright © 2018 Elsevier B.V. All rights reserved.

  7. Dens invaginatus (dilated odontome) in mandibular canine.

    Science.gov (United States)

    Halawar, Sangamesh S; Satyakiran, Gvv; Krishnanand, Ps; Prashanth, R

    2014-09-01

    Dens invaginatus is a developmental malformation of teeth related to shape of the teeth. Affected teeth show a deep infolding of enamel and dentin starting from the tip of the cusps and may extend deep into the root. It results from the invagination of the enamel organ into the dental papilla before calcification has occurred. Teeth most affected are maxillary lateral incisors. The presence of dens invaginatus in mandibular canine is extremely rare. The tooth was symptomatic in that it was mobile and was oriented horizontally. This article presents a case of symptomatic dens invaginatus in mandibular canine.

  8. Pathogenesis of Mucormycosis

    Science.gov (United States)

    Spellberg, Brad; Walsh, Thomas J.; Kontoyiannis, Dimitrios P.

    2012-01-01

    Mucormycosis is a life-threatening infection that occurs in patients who are immunocompromised because of diabetic ketoacidosis, neutropenia, organ transplantation, and/or increased serum levels of available iron. Because of the increasing prevalence of diabetes mellitus, cancer, and organ transplantation, the number of patients at risk for this deadly infection is increasing. Despite aggressive therapy, which includes disfiguring surgical debridement and frequently adjunctive toxic antifungal therapy, the overall mortality rate is high. New strategies to prevent and treat mucormycosis are urgently needed. Understanding the pathogenesis of mucormycosis and the host response to invading hyphae ultimately will provide targets for novel therapeutic interventions. In this supplement, we review the current knowledge about the virulence traits used by the most common etiologic agent of mucormycosis, Rhizopus oryzae. Because patients with elevated serum levels of available iron are uniquely susceptible to mucormycosis and these infections are highly angioinvasive, emphasis is placed on the ability of the organism to acquire iron from the host and on its interactions with endothelial cells lining blood vessels. Several promising therapeutic strategies in preclinical stages are identified. PMID:22247441

  9. Kaposi sarcoma herpesvirus pathogenesis.

    Science.gov (United States)

    Mariggiò, Giuseppe; Koch, Sandra; Schulz, Thomas F

    2017-10-19

    Kaposi sarcoma herpesvirus (KSHV), taxonomical name human gammaherpesvirus 8, is a phylogenetically old human virus that co-evolved with human populations, but is now only common (seroprevalence greater than 10%) in sub-Saharan Africa, around the Mediterranean Sea, parts of South America and in a few ethnic communities. KSHV causes three human malignancies, Kaposi sarcoma, primary effusion lymphoma, and many cases of the plasmablastic form of multicentric Castleman's disease (MCD) as well as occasional cases of plasmablastic lymphoma arising from MCD; it has also been linked to rare cases of bone marrow failure and hepatitis. As it has colonized humans physiologically for many thousand years, cofactors are needed to allow it to unfold its pathogenic potential. In most cases, these include immune defects of genetic, iatrogenic or infectious origin, and inflammation appears to play an important role in disease development. Our much improved understanding of its life cycle and its role in pathogenesis should now allow us to develop new therapeutic strategies directed against key viral proteins or intracellular pathways that are crucial for virus replication or persistence. Likewise, its limited (for a herpesvirus) distribution and transmission should offer an opportunity for the development and use of a vaccine to prevent transmission.This article is part of the themed issue 'Human oncogenic viruses'. © 2017 The Authors.

  10. Den melankolske europæer

    DEFF Research Database (Denmark)

    Krejberg, Kasper Green

    2006-01-01

    Den europæiske identitet hører sammen med en selvbevidst melankoli. Det mener i hvert fald den tyske forfatter W.G. Sebald, hvis hovedværk Austerlitz advarer om, at vores fælles fortid løber os af hænde, hvis ikke vi insisterer på Europas enestående erindringsressourcer......Den europæiske identitet hører sammen med en selvbevidst melankoli. Det mener i hvert fald den tyske forfatter W.G. Sebald, hvis hovedværk Austerlitz advarer om, at vores fælles fortid løber os af hænde, hvis ikke vi insisterer på Europas enestående erindringsressourcer...

  11. Rare associations of dens invaginatus and mesiodens.

    Science.gov (United States)

    Sannomiya, Eduardo Kazuo; Asaumi, Jun-ichi; Kishi, Kanji; Dalben, Gisele da Silva

    2007-08-01

    Dens invaginatus is a developmental variation resulting from an alteration in the normal growth pattern of the dental papilla. Synonyms of this disturbance include dens in dente, invaginated odontome, tooth inclusion, and dentoid in dente. Radiographically, it is observed as infolding of a radiopaque ribbon-like structure, with equal density as enamel, extending from the cingulum into the root canal and sometimes reaching the root apex, assigning the appearance of a small tooth within the coronal pulp cavity. This article presents 2 case reports. The first describes an 8-year-old girl with dens invaginatus in a mesiodens; the second report describes a 16-year-old boy presenting with 2 mesiodens, both associated with dens invaginatus.

  12. van den Heuvel, Prof. Edward P J

    Indian Academy of Sciences (India)

    van den Heuvel, Prof. Edward P J . Date of birth: 2 November 1940. Address: Professor of Astrophysics, Astronomical Inst. Anton Pannekoek, Postbus 94249, 1090 GE Amsterdam, The Netherlands Contact: Office: (+31-20) 525 ...

  13. Motivation af den Kreative Sælger

    OpenAIRE

    Sørensen, Mikkel Vallentin; Floor, Jeppe Hjelmsted

    2012-01-01

    Projektet tager udgangspunkt i motivationen af danske sælgere. Med inspiration fra den positive psykologiske videnskab, udfordres eksisterende motivationsredskaber, med henblik på at motivere den enkelte medarbejder til at yde et bedre stykke arbejde for virksomheden. Daniel Pink, Bruno Frey og Frederick Herzberg danner det teoretiske grundlag for opgaven, og problemstillingen undersøges gennem en sammenholdelse af deres teorier med empirisk materiale i en fænomenologisk tilgang. Rapporten af...

  14. Læring og den kulturhistoriske skole

    DEFF Research Database (Denmark)

    Broström, Stig

    2007-01-01

    -forskere uddrager den grundlæggende forståelse af forholdet mellem læring og udvikling. Nemlig at læring og udvikling indgår i en dialektisk enhed og virker gensidigt ind på hinanden - dog således at læring kommer ført, den trækker udviklingen med sig og så at sige leder udviklingen. Vygotskys tese vedrørende...

  15. Den ma(d)skuline smag

    DEFF Research Database (Denmark)

    Leer, Jonatan

    2014-01-01

    madtv-scenen, var der primært to forskellige mandlige figurer på dette felt. Enten var man(d) en frankofil levemand, som var godt oppe i årene, eller også var man en professionel kok i uniform. Den første gruppe har den danske historiker Caroline Nyvang betegnet for ’gourmænd’. De betoner det...

  16. Pathogenesis of Parkinson's disease

    OpenAIRE

    Riederer, Peter; Lange, Klaus W.

    1992-01-01

    The importance of genetic aspects, ageing, environmental factors, head trauma, defective mitochondrial respiration, altered iron metabolism, oxidative stress and glutamatergic overactivity of the basal ganglia in the pathogenesis of Parkinson's disease (PD) are considered in this review.

  17. Viral pathogenesis in diagrams

    National Research Council Canada - National Science Library

    Tremblay, Michel; Berthiaume, Laurent; Ackermann, Hans-Wolfgang

    2001-01-01

    .... The 268 diagrams in Viral Pathogenesis in Diagrams were selected from over 800 diagrams of English and French virological literature, including one derived from a famous drawing by Leonardo da Vinci...

  18. Remote identification of maternal polar bear (Ursus maritimus) denning habitat on the Colville River Delta, Alaska

    Science.gov (United States)

    Blank, Justin J.

    High resolution digital aerial photographs (1 foot pixel size) of the Colville River Delta, Alaska were examined in 3D, with the use of a digital photogrammetric workstation. Topographic features meeting the criteria required for adequate snow accumulation, and subsequent construction of terrestrial polar bear maternal dens, were identified and digitized into an ArcGIS line shapefile. Effectiveness, efficiency, and accuracy were improved when compared to previous polar bear denning habitat efforts which utilized contact photo prints and a pocket stereoscope in other geographic areas of northern Alaska. Accuracy of photograph interpretation was systematically evaluated visually from the air with the use of a helicopter and physically on the ground. Results show that the mapping efforts were successful in identifying den habitat 91.3% of the time. Knowledge denning habitat can improve and inform decision making by managers and regulators when considering travel and development in the study area. An understanding of polar bear denning habitat extent and location will be a crucial tool for planning activities within the study area in a way that minimizes conflicts with maternal dens.

  19. Pathogenesis of bovine neosporosis.

    Science.gov (United States)

    Dubey, J P; Buxton, D; Wouda, W

    2006-05-01

    The protozoan parasite Neospora caninum is a major pathogen of cattle and dogs, being a significant cause of abortion in cattle in many countries. It is one of the most efficiently transmitted parasites, with up to 90% of cattle infected in some herds. The pathogenesis of abortion due to Neospora is complex and only partially understood. Losses occur after a primary infection during pregnancy but more commonly as the result of recrudescence of a persistent infection during pregnancy. Parasitaemia is followed by invasion of the placenta and fetus. It is suggested that abortion occurs when primary parasite-induced placental damage jeopardises fetal survival directly or causes release of maternal prostaglandins that in turn cause luteolysis and abortion. Fetal damage may also occur due to primary tissue damage caused by the multiplication of N. caninum in the fetus or due to insufficient oxygen/nutrition, secondary to placental damage. In addition, maternal immune expulsion of the fetus may occur associated with maternal placental inflammation and the release of maternal pro-inflammatory cytokines in the placenta. Thus N. caninum is a primary pathogen capable of causing abortion either through maternal placental inflammation, maternal and fetal placental necrosis, fetal damage, or a combination of all three. The question of how N. caninum kills the fetus exposes the complex and finely balanced biological processes that have evolved to permit bovine and other mammalian pregnancies to occur. Defining these immunological mechanisms will shed light on potential methods of control of bovine neosporosis and enrich our understanding of the continuity of mammalian and protozoal survival.

  20. Epigenetics and Colorectal Cancer Pathogenesis

    International Nuclear Information System (INIS)

    Bardhan, Kankana; Liu, Kebin

    2013-01-01

    Colorectal cancer (CRC) develops through a multistage process that results from the progressive accumulation of genetic mutations, and frequently as a result of mutations in the Wnt signaling pathway. However, it has become evident over the past two decades that epigenetic alterations of the chromatin, particularly the chromatin components in the promoter regions of tumor suppressors and oncogenes, play key roles in CRC pathogenesis. Epigenetic regulation is organized at multiple levels, involving primarily DNA methylation and selective histone modifications in cancer cells. Assessment of the CRC epigenome has revealed that virtually all CRCs have aberrantly methylated genes and that the average CRC methylome has thousands of abnormally methylated genes. Although relatively less is known about the patterns of specific histone modifications in CRC, selective histone modifications and resultant chromatin conformation have been shown to act, in concert with DNA methylation, to regulate gene expression to mediate CRC pathogenesis. Moreover, it is now clear that not only DNA methylation but also histone modifications are reversible processes. The increased understanding of epigenetic regulation of gene expression in the context of CRC pathogenesis has led to development of epigenetic biomarkers for CRC diagnosis and epigenetic drugs for CRC therapy

  1. Epigenetics and Colorectal Cancer Pathogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Bardhan, Kankana; Liu, Kebin, E-mail: Kliu@gru.edu [Department of Biochemistry and Molecular Biology, Medical College of Georgia, and Cancer Center, Georgia Regents University, Augusta, GA 30912 (United States)

    2013-06-05

    Colorectal cancer (CRC) develops through a multistage process that results from the progressive accumulation of genetic mutations, and frequently as a result of mutations in the Wnt signaling pathway. However, it has become evident over the past two decades that epigenetic alterations of the chromatin, particularly the chromatin components in the promoter regions of tumor suppressors and oncogenes, play key roles in CRC pathogenesis. Epigenetic regulation is organized at multiple levels, involving primarily DNA methylation and selective histone modifications in cancer cells. Assessment of the CRC epigenome has revealed that virtually all CRCs have aberrantly methylated genes and that the average CRC methylome has thousands of abnormally methylated genes. Although relatively less is known about the patterns of specific histone modifications in CRC, selective histone modifications and resultant chromatin conformation have been shown to act, in concert with DNA methylation, to regulate gene expression to mediate CRC pathogenesis. Moreover, it is now clear that not only DNA methylation but also histone modifications are reversible processes. The increased understanding of epigenetic regulation of gene expression in the context of CRC pathogenesis has led to development of epigenetic biomarkers for CRC diagnosis and epigenetic drugs for CRC therapy.

  2. Studie af den amerikanske doktrin for Counterinsurgency

    DEFF Research Database (Denmark)

    Møller, Nicolai Stahlfest

    2006-01-01

    Specialet omhandler den amerikanske doktrin for Counter-insurgency under den givne overordnede problemstilling asymmetri. Erfaringerne fra Irak og Afghanistan har forårsaget den nyskrivning af doktrinen, som behandles efterfølgende. Doktrinen er potentielt interessant for Danmark, grundet valget af...... strategisk partner, og den mulige indsættelse i missioner, hvor kontakt med, og måske bekæmpelse af, fjendtlige oprørsbevægelser vil forekomme. Maos teori og den nyere radikale islams teori ses som værende repræsentative for oprørsbevægelser ift. både amerikanske erfaringer og det forventede danske...... synes også at være udtalt i imødegåelsen af radikal islam, hvilket er en stor udfordring for både militære og civile myndigheder og organisationer. For at fungere som COIN enhed kræver det veluddannede enheder, da de udover de basale soldateropgaver også skal kunne støtte ifm. CIMIC opgaver, løsning af...

  3. Leadership pipeline i den offentlige sektor

    DEFF Research Database (Denmark)

    Dahl, Kristian Aagaard; Molly-Søholm, Thorkil

    en rejse ind i hjertet af offentlig ledelse med fokus på lederniveauerne: topchef, funktionel chef, leder af ledere og leder af medarbejdere. Med afsæt i righoldige eksempler og fortællinger fra virkeligheden introduceres læseren for ledelsesteorien den Offentlige Leadership Pipeline, som giver...... enkelte lederniveauer og udvikle ledertalenter. Teorien byder på et detaljeret ledelsesgrundlag, hvorudfra den offentlige organisation kan bygge en professionel værdikæde for ledelse ved at forme lederprofiler, -rekruttering, -uddannelse, -evaluering m.m. Leadership Pipeline i den offentlige sektor er...... baseret på et treårigt dansk praksisorienteret forskningsprojekt med deltagelse af 15 offentlige organisationer, som repræsenterer kommunerne, regionerne og staten. Projektet har videreudviklet en af de sidste 10 års mest indflydelsesrige ledelseteorier i de største private organisationer, Leadership...

  4. Dens invaginatus: diagnosis and management strategies.

    Science.gov (United States)

    Gallacher, A; Ali, R; Bhakta, S

    2016-10-07

    Dens invaginatus is a developmental malformation, in which there is an infolding of enamel into dentine. These infolds represent stagnation sites for bacteria and can predispose to dental caries. The carious infection can spread via enamel and dentine to contaminate the pulp and cause soft tissue necrosis. The altered and sometimes complex anatomy of affected teeth can make endodontic management challenging. Early diagnosis is therefore essential as prophylactic treatment of the dens can prevent degeneration and pulpal necrosis. The aim of this article is to review the aetiology, classification, diagnosis and management of teeth affected with dens invaginatus. Emphasis will be placed on describing the clinical features of this anomaly. Treatment options, management strategies and the challenges faced in managing this condition will be discussed.

  5. Dens invaginatus”: A Series of case reports

    Directory of Open Access Journals (Sweden)

    S R Ashwinirani

    2018-01-01

    Full Text Available Dens invaginatus is a developmental anomaly resulting from an invagination in the surface of a tooth crown before its calcification. It involves more commonly maxillary anterior teeth. Dens invaginatus with supernumerary teeth and double dens invagintus were also reported. The management of dens invaginatus includes simple prophylactic restoration to conventional endodontic treatment or extraction, depending on the type of invagination, function, esthetics, and morphology of the root canal. Extraction is indicated as a last choice of treatment in cases of failure of root canal treatment and in supernumerary teeth associated with dens invaginatus. In this paper, we have reported a series of cases of dens invagintus.

  6. Den danske kulturmodel og det nye Europa

    DEFF Research Database (Denmark)

    Duelund, Peter

    1993-01-01

    Hvad er det specielt danske? Er der udsigt til, at dette specialt danske gradvist vil blive afsløst i en europæisk enhedskultur? Eller giver den økonomiske integration mulighed for større lokale og regionale kulturelle forskelle?......Hvad er det specielt danske? Er der udsigt til, at dette specialt danske gradvist vil blive afsløst i en europæisk enhedskultur? Eller giver den økonomiske integration mulighed for større lokale og regionale kulturelle forskelle?...

  7. Portræt: Den koreanske dansker

    DEFF Research Database (Denmark)

    Henriksen, Carsten

    2009-01-01

    Lene Myong Petersen har som den første i Danmark skrevet ph.d.-afhandling om adoption. Og ifølge Lene Myong Petersen er det belastede begreb om race ikke til at slippe uden om, hvis man vil forstå vilkårene for adopterede i Danmark.......Lene Myong Petersen har som den første i Danmark skrevet ph.d.-afhandling om adoption. Og ifølge Lene Myong Petersen er det belastede begreb om race ikke til at slippe uden om, hvis man vil forstå vilkårene for adopterede i Danmark....

  8. Tagungsbericht: Den Alltag unter die Lupe genommen

    OpenAIRE

    Allolio-Näcke, Lars

    2003-01-01

    Die Tagung "Alltag im Aufbruch. Ein psychologisches Profil der Gegenwartskultur" beschäftigte sich mit dem Phänomen des gelebten Alltags in unserer und in anderen Kulturen. Im Unterschied zur Mainstream-Psychologie lag der Fokus der Tagung auf den kulturellen Konstruktionen von Sinn und Bedeutung als intentionalen Prozessen und wandte sich entschieden gegen jede Form der "Naturalisierung des Mentalen". Dem Alltäglichen näherten sich Beiträge aus den Themenbereichen Zeitkultur, Gefährdete Kult...

  9. Dragons' Den: promoting healthcare research and innovation.

    Science.gov (United States)

    Mazhindu, Deborah; Gregory, Siobhan

    2015-07-01

    The changing health and social care landscape, and, in particular, the financial challenges affecting the NHS, can present difficulties for staff looking for funding to support innovation and new ways of working. One method of competitive tendering that is becoming more accepted as a way of allocating funds, encouraging staff engagement and developing innovation for research is a format based the BBC television series, Dragons' Den. This article describes how Hounslow and Richmond Community Healthcare NHS Trust, London, has developed a 'Dragons' Den initiative' of annual competitive research funding allocation to ensure that some of the most dynamic practice in the trust is captured.

  10. Den empiriske uddannelsesvidenskab og kvalitet i studieaktivitet

    DEFF Research Database (Denmark)

    Keiding, Tina Bering; Qvortrup, Ane

    2015-01-01

    Bidraget kobler studieaktivitetesmodellen med kvalitetsindikatorer for god undervisning, og viler blandt andet, hvorledes modellen kan støtte samtænkning af forskellige undervisnings- og læringsformater med henblik på øge den aktive læretid......Bidraget kobler studieaktivitetesmodellen med kvalitetsindikatorer for god undervisning, og viler blandt andet, hvorledes modellen kan støtte samtænkning af forskellige undervisnings- og læringsformater med henblik på øge den aktive læretid...

  11. Pathogenesis of Hepatic Encephalopathy

    Directory of Open Access Journals (Sweden)

    Irena Ciećko-Michalska

    2012-01-01

    Full Text Available Hepatic encephalopathy can be a serious complication of acute liver failure and chronic liver diseases, predominantly liver cirrhosis. Hyperammonemia plays the most important role in the pathogenesis of hepatic encephalopathy. The brain-blood barrier disturbances, changes in neurotransmission, neuroinflammation, oxidative stress, GABA-ergic or benzodiazepine pathway abnormalities, manganese neurotoxicity, brain energetic disturbances, and brain blood flow abnormalities are considered to be involved in the development of hepatic encephalopathy. The influence of small intestine bacterial overgrowth (SIBO on the induction of minimal hepatic encephalopathy is recently emphasized. The aim of this paper is to present the current views on the pathogenesis of hepatic encephalopathy.

  12. Pathogenesis of Acanthamoeba Keratitis

    Science.gov (United States)

    Panjwani, Noorjahan

    2010-01-01

    Acanthamoeba keratitis (AK) is a serious infection of the cornea. At present, diagnosis of the disease is not straightforward and treatment is very demanding. While contact lens wear is the leading risk factor for AK, Acanthamoeba parasites are increasingly recognized as an important cause of keratitis in non-contact lens wearers. The first critical step in the pathogenesis of infection is the adhesion of the microbe to the surface of the host tissues. Acanthamoebae express a major virulence protein, the mannose-binding protein (MBP), which mediates the adhesion of amoebae to the surface of the cornea. The MBP is a transmembrane protein with characteristics of a typical cell surface receptor. Subsequent to the MBP-mediated adhesion to host cells, the amoebae produce a contact-dependent metalloproteinase and several contact-independent serine proteinases. These proteinases work in concert to produce a potent cytopathic effect (CPE) involving killing of the host cells, degradation of epithelial basement membrane and underlying stromal matrix, and penetration into the deeper layers of the cornea. In the hamster animal model, oral immunization with the recombinant MBP protects against AK, and this protection is associated with an increased level of anti-MBP IgA in tears of protected animals. Normal human tear fluid contains IgA antibodies against Acanthamoeba MBP that is likely to provide protection by inhibiting the adhesion of parasites to host cells. Indeed, in in vitro CPE assays, even a low concentration of tears (10 [MU]μL of undiluted tears per milliliter of media) almost completely inhibits Acanthamoeba-induced CPE. In addition to adherence-inhibiting, IgA-mediated protection, human tears also contain IgA-independent factors that provide protection against Acanthamoeba-induced CPE by inhibiting the activity of cytotoxic proteinases. Characterization of the CPE-inhibitory factors of human tears should lead to a better understanding of the mechanism by which the

  13. Molecular Pathogenesis of Spondyloarthritis

    DEFF Research Database (Denmark)

    Carlsen, Thomas Gelsing

    This dissertation includes a presentation of knowledge on the molecular pathogenesis of spondyloarthritis achieved through a PhD programme at Aalborg University from 1.12.2011 - 1.12.2014. Work was carried out in the Laboratory of Medical Mass Spectrometry, headed by: Professor Svend Birkelund...

  14. A rare presentation of multiple dens invaginatus in maxillary dentition

    OpenAIRE

    Purani, Jigar M; Purani, Hiral J

    2014-01-01

    Dens invaginatus is a developmental disturbance of the tooth and usually occurs in the maxillary lateral incisor of permanent dentition. In this article, a rare case of dens invaginatus affecting multiple permanent maxillary teeth is described.

  15. Ledelse og motivation i den offentlige sektor

    DEFF Research Database (Denmark)

    Thuesen, Frederik

    Rapporten er et litteraturstudium, der belyser rammer for ledelse og arbejdstilrettelæggelse i den offentlige sektor. Rapporten afdækker, hvad der motiverer ledere og medarbejdere, og ledernes muligheder for gennem dialog med medarbejderne at udvikle en arbejdsplads, der er kendetegnet ved arbejd...

  16. Den udødelige gangster

    DEFF Research Database (Denmark)

    Bjerre, Thomas Ærvold

    2009-01-01

    Hollywood har igennem et århundrede hyldet de voldspsykopater, som de fleste gangstere nu engang er. Michael Manns Public Enemies er seneste skud på stammen i den lange række af amerikanske gangsterfilm, der tog sin begyndelse i starten af 1930'erne, og som meget hurtig blev til en mytisk...

  17. Tre teorier om den moralske udvikling

    DEFF Research Database (Denmark)

    Bo, Inger Glavind; Andreasen, Brian Kjær

    I artiklen gennemgås tre forskellige men teorihistorisk relaterede perspektiver på forståelsen af moralsk udvikling: Piaget, Kohlberg og Gilligan. I den efterfølgende diskussion af disse teoretikeres respektive positioner påpeges såvel forskelle som ligheder i deres betoning af moralens karakter...

  18. Joop van den Bremen, Streektaalmuziek in Nederland

    NARCIS (Netherlands)

    A.J.C. van der Hoeven (Arno)

    2015-01-01

    textabstractIn 1996, folk music fan Joop van den Bremen started his website Streektaalmuziek in Nederland (“Regional language music in the Netherlands”).1 On this website he collects information on Dutch musicians singing in dialect.2 As of September 2014, his still expanding database contains 6,164

  19. Inputorienteret oparbejdelse af den grammatikalske kompetence

    DEFF Research Database (Denmark)

    Ambjørn, Lone

    2001-01-01

    De forskellige teoretiske opfattelser, der ligger til grund for hhv. den output- og inputorienterede metode, beskrives. Der opstilles et eksempel på en grammatisk øvelsestypologi baseret på principperne i en input-orienteret læringsmodel....

  20. Hvordan beskriver man den fragmenterede by

    DEFF Research Database (Denmark)

    Lund, Nils-Ole

    1996-01-01

    En af otte kommentarer under titlen: "Kommentarer til 'Den oversete by' - det sansende" til udstilling i Charlottenborg, som indledte Kulturbyåret. Såvel udstillingsforfatterne som fotos fra udstillingen søger at modgå en række stærkt kritiske indlæg mod denne form for arkitekturformidling....

  1. Demokratiseringen af den politiske diskurs i Polen

    DEFF Research Database (Denmark)

    Arnfast, Juni Søderberg

    1999-01-01

    Gennem en analyse af brugen af personlige pronominer i politiske tekster fra udvalgte, polske medier diskuteres forandringerne i den polske, politiske diskurs gennem 1980'erne. Det påvises at det kommunistiske styres anvendelse af pronominet 'vi' skifter konnotationer i retning af en mindre ideol...

  2. Den skrøbelige sandhed

    DEFF Research Database (Denmark)

    Pedersen, Peter Ole

    2010-01-01

    dokumentationer. Denne udvikling kan også spores til den aktivistiske dokumentar, hvor filmene på samme tid fungerer som politiske argumenter og kritiske collager af mediernes overvældende informationsstrøm. Hensigten er, at fremvise hvordan denne type produktioner indgår i en subjektivistisk orienteret diskurs...

  3. Den drikfældige engel?

    DEFF Research Database (Denmark)

    Eriksen, Sidsel

    1991-01-01

    Artiklen opfatter kvinders særlige drikkemønstre som et udslag af kultur og ikke (blot) som en konsekvens af kvindens særlige biologi. Udgangspunktet er, at drikkeri ikke passer sammen med den traditionelle kvinderolle. Endnu værre er det dog, hvis kvinder drak i offentligheden. Det er formentlig...

  4. Nyliberalisme, universiteter og den akademiske frihed

    DEFF Research Database (Denmark)

    Madsen, Mogens Ove

    2011-01-01

    Den akademiske frihed er forbundet med absolut frihed til at frembringe og videreformidle viden. Denne ide med universitetet er blevet udfordret ganske kraftigt i de senere år, ikke kun i Danmark. Stærke rådgivningsinstitutioner som OECD og EU har i en del år anbefalet, at universiteternes opgave...

  5. van den Heuvel, Prof. Edward P J

    Indian Academy of Sciences (India)

    Email: e.p.j.vandenheuvel@uva.nl, ed.van.den.heuvel@gmail.com. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on the teaching of the theory of evolution more... ACADEMY PUBLIC LECTURE:

  6. Digital kommunikation med den offentlige sektor

    DEFF Research Database (Denmark)

    Berger, Jesper Bull; Andersen, Kim Normann

    , som enten via spørgeskema, e-mail eller telefon har givet os et enestående indblik i deres håndtering af den digitale kommunikation. Publikationen er et såkaldt workingpaper, hvor vi mere end gerne modtager forslag og kommentarer til forbedringer. Der er i publikationen en række aktive links til...

  7. Hjernerum - Den følelsesfulde hjerne

    DEFF Research Database (Denmark)

    Kringelbach, Morten L.

    Learning Lab Denmark/Peoples Press, Copenhagen. 2004 Kort beskrivelse: 'Hjernerum' er en fortælling fra hjerneforskningens frontlinie om de nyeste indsigter i den følelsesfulde hjerne. Med udgangspunkt i egen forskning og historisk indsigt i alt fra videnskabs- til litteratur- og kunsthistorie, t...

  8. Flaskevand - den rene vare i brandingens tidsalder

    DEFF Research Database (Denmark)

    Hermansen, Judy

    2008-01-01

    At tappe vand på flasker er blevet den mest udbredte globale virksomhed overhovedet, og forbruget af flaskevand stiger fortsat hurtigt - især i lande hvor man kan få rent drikkevand direkte fra hanen gratis eller til en meget billig penge. Hvorfor er vi havnet i sådan et tilsyneladende paradoksal...

  9. Combined Surgical and Nonsurgical Endodontic Therapy in the Treatment of Dens Invaginatus Type 3: A Case Report

    Science.gov (United States)

    Marwah, Nikhil; Goenka, Puneet; Nigam, Anant Gopal; GS, Prathima

    2009-01-01

    An accurate understanding of the morphology of the root canal system is a prerequisite for successful root canal treatment. Invaginated teeth have a complex root canal configuration that cannot be instrumented effectively. Correct diagnosis and treatment planning are fundamental to treatment of dens invaginatus. Periapical surgery is indicated in cases where a nonsurgical approach fails. A case of dens invaginatus type 3 in a maxillary lateral incisor with a periapical lesion and its successful treatment by these combined methods is reported. PMID:25206122

  10. Dens evaginatus and dens invaginatus in a double tooth: A rare case report.

    Science.gov (United States)

    Sharma, Gaurav; Mutneja, Anudeep R; Nagpal, Archna; Mutneja, Puneet

    2015-01-01

    The presence of dens invaginatus (DI) and dens evaginatus (DE) on same tooth is a rare phenomenon. However, when these dental anomalies occur on a double tooth, it becomes an extremely rare phenomenon. The authors report a rare case of DI and DE on fused permanent maxillary central incisor with supernumerary tooth in a 40-year-old male. The present article also focuses on the differentiating fusion from gemination and also reviews preventive and management strategies for tooth with complex dental anatomy.

  11. Human disturbances of denning polar bears in Alaska

    Energy Technology Data Exchange (ETDEWEB)

    Amstrup, S.C. (Alaska Fish and Wildlife Research Center, Anchorage, AK (United States))

    1993-09-01

    Polar bears (Ursus maritimus) give birth in dens of snow and ice. The altricial neonates cannot leave the den for >2 months post-partum and are potentially vulnerable to disturbances near dens. The coastal plain (1002) area of Alaska's Arctic National Wildlife Refuge (ANWR) lies in a region of known polar bear denning and also may contain >9 billion barrels of recoverable oil. Polar bears in dens could be affected in many ways by hydrocarbon development. The distribution of dens on ANWR was documented between 1981 and 1992 and responses of bears in dens to various anthropogenic disturbances were observed. Of 44 dens located by radiotelemetry on the mainland coast of Alaska and Canada, 20 (45%) were on ANWR and 15 (34%) were within the 1002 area. Thus, development of ANWR will increase the potential that denning polar bears are disturbed by human activities. However, perturbations resulting from capture, marking, and radiotracking maternal bears did not affect litter sizes or stature of cubs produced. Likewise, 10 of 12 denned polar bears tolerated exposure to exceptional levels of activity. This tolerance and the fact that investment in the denning effort increases through the winter indicated that spatial and temporal restrictions on developments could prevent the potential for many disruptions of denned bears from being realized. 16 refs., 1 fig., 2 tabs.

  12. Human disturbances of denning polar bears in Alaska

    International Nuclear Information System (INIS)

    Amstrup, S.C.

    1993-01-01

    Polar bears (Ursus maritimus) give birth in dens of snow and ice. The altricial neonates cannot leave the den for >2 months post-partum and are potentially vulnerable to disturbances near dens. The coastal plain (1002) area of Alaska's Arctic National Wildlife Refuge (ANWR) lies in a region of known polar bear denning and also may contain >9 billion barrels of recoverable oil. Polar bears in dens could be affected in many ways by hydrocarbon development. The distribution of dens on ANWR was documented between 1981 and 1992 and responses of bears in dens to various anthropogenic disturbances were observed. Of 44 dens located by radiotelemetry on the mainland coast of Alaska and Canada, 20 (45%) were on ANWR and 15 (34%) were within the 1002 area. Thus, development of ANWR will increase the potential that denning polar bears are disturbed by human activities. However, perturbations resulting from capture, marking, and radiotracking maternal bears did not affect litter sizes or stature of cubs produced. Likewise, 10 of 12 denned polar bears tolerated exposure to exceptional levels of activity. This tolerance and the fact that investment in the denning effort increases through the winter indicated that spatial and temporal restrictions on developments could prevent the potential for many disruptions of denned bears from being realized. 16 refs., 1 fig., 2 tabs

  13. Premolarized double dens in dente in albinism - A case report

    Directory of Open Access Journals (Sweden)

    Suprabha B

    2005-09-01

    Full Text Available Dens in dente are known to be associated with many dental abnormalities such as taurodontism microdontia, gemination, and dens evaginatus. This paper describes a rare case of double dens in dente in a lateral incisor with crown morphology similar to a premolar present in a patient with features of albinism. Problems associated with this condition and their management is discussed.

  14. Pathogenesis of oral FIV infection

    Science.gov (United States)

    Miller, Craig; Boegler, Karen; Carver, Scott; MacMillan, Martha; Bielefeldt-Ohmann, Helle

    2017-01-01

    Feline immunodeficiency virus (FIV) is the feline analogue of human immunodeficiency virus (HIV) and features many hallmarks of HIV infection and pathogenesis, including the development of concurrent oral lesions. While HIV is typically transmitted via parenteral transmucosal contact, recent studies prove that oral transmission can occur, and that saliva from infected individuals contains significant amounts of HIV RNA and DNA. While it is accepted that FIV is primarily transmitted by biting, few studies have evaluated FIV oral infection kinetics and transmission mechanisms over the last 20 years. Modern quantitative analyses applied to natural FIV oral infection could significantly further our understanding of lentiviral oral disease and transmission. We therefore characterized FIV salivary viral kinetics and antibody secretions to more fully document oral viral pathogenesis. Our results demonstrate that: (i) saliva of FIV-infected cats contains infectious virus particles, FIV viral RNA at levels equivalent to circulation, and lower but significant amounts of FIV proviral DNA; (ii) the ratio of FIV RNA to DNA is significantly higher in saliva than in circulation; (iii) FIV viral load in oral lymphoid tissues (tonsil, lymph nodes) is significantly higher than mucosal tissues (buccal mucosa, salivary gland, tongue); (iv) salivary IgG antibodies increase significantly over time in FIV-infected cats, while salivary IgA levels remain static; and, (v) saliva from naïve Specific Pathogen Free cats inhibits FIV growth in vitro. Collectively, these results suggest that oral lymphoid tissues serve as a site for enhanced FIV replication, resulting in accumulation of FIV particles and FIV-infected cells in saliva. Failure to induce a virus-specific oral mucosal antibody response, and/or viral capability to overcome inhibitory components in saliva may perpetuate chronic oral cavity infection. Based upon these findings, we propose a model of oral FIV pathogenesis and suggest

  15. Pathogenesis of oral FIV infection.

    Directory of Open Access Journals (Sweden)

    Craig Miller

    Full Text Available Feline immunodeficiency virus (FIV is the feline analogue of human immunodeficiency virus (HIV and features many hallmarks of HIV infection and pathogenesis, including the development of concurrent oral lesions. While HIV is typically transmitted via parenteral transmucosal contact, recent studies prove that oral transmission can occur, and that saliva from infected individuals contains significant amounts of HIV RNA and DNA. While it is accepted that FIV is primarily transmitted by biting, few studies have evaluated FIV oral infection kinetics and transmission mechanisms over the last 20 years. Modern quantitative analyses applied to natural FIV oral infection could significantly further our understanding of lentiviral oral disease and transmission. We therefore characterized FIV salivary viral kinetics and antibody secretions to more fully document oral viral pathogenesis. Our results demonstrate that: (i saliva of FIV-infected cats contains infectious virus particles, FIV viral RNA at levels equivalent to circulation, and lower but significant amounts of FIV proviral DNA; (ii the ratio of FIV RNA to DNA is significantly higher in saliva than in circulation; (iii FIV viral load in oral lymphoid tissues (tonsil, lymph nodes is significantly higher than mucosal tissues (buccal mucosa, salivary gland, tongue; (iv salivary IgG antibodies increase significantly over time in FIV-infected cats, while salivary IgA levels remain static; and, (v saliva from naïve Specific Pathogen Free cats inhibits FIV growth in vitro. Collectively, these results suggest that oral lymphoid tissues serve as a site for enhanced FIV replication, resulting in accumulation of FIV particles and FIV-infected cells in saliva. Failure to induce a virus-specific oral mucosal antibody response, and/or viral capability to overcome inhibitory components in saliva may perpetuate chronic oral cavity infection. Based upon these findings, we propose a model of oral FIV pathogenesis

  16. Molecular Pathogenesis of Neuromyelitis Optica

    Directory of Open Access Journals (Sweden)

    Simon A Broadley

    2012-10-01

    Full Text Available Neuromyelitis optica (NMO is a rare autoimmune disorder, distinct from multiple sclerosis, causing inflammatory lesions in the optic nerves and spinal cord. An autoantibody (NMO IgG against aquaporin-4 (AQP4, a water channel expressed on astrocytes is thought to be causative. Peripheral production of the antibody is triggered by an unknown process in genetically susceptible individuals. Anti-AQP4 antibody enters the central nervous system (CNS when the blood brain barrier is made permeable and has high affinity for orthogonal array particles of AQP4. Like other autoimmune diseases, Th17 cells and their effector cytokines (such as interleukin 6 have been implicated in pathogenesis. AQP4 expressing peripheral organs are not affected by NMO IgG, but the antibody causes extensive astrocytic loss in specific regions of the CNS through complement mediated cytotoxicity. Demyelination occurs during the inflammatory process and is probably secondary to oligodendrocyte apoptosis subsequent to loss of trophic support from astrocytes. Ultimately, extensive axonal injury leads to severe disability. Despite rapid advances in the understanding of NMO pathogenesis, unanswered questions remain, particularly with regards to disease mechanisms in NMO IgG seronegative cases. Increasing knowledge of the molecular pathology is leading to improved treatment strategies.

  17. Erhvervsliv og politik i Den Europæiske Union

    DEFF Research Database (Denmark)

    Nedergaard, Peter

    socialkonstruktivismen tager sig af de ændrede politiske præferencer og rational choice-teorien sig af de langt mere konstante politiske institutioner. Den foreslåede teori anvendes til forklaring af de politiske resultater af tre vigtige reformer af EU's landbrugspolitik i 1984, 1992 og 2003. Den viser sig i stand til......Artiklen diskuterer anvendelige teorier for analysen af den økonomisk-politiske integration i EU's politiske system, som i dag er langt den vigtigste reguleringsramme om virksomhederne i EU. I den forbindelse foreslår artiklen en såkaldt socialkonstruktivistisk rational choice-teori, hvor...

  18. Jamie Oliver i den gode smags tjeneste

    DEFF Research Database (Denmark)

    Leer, Jonatan

    2014-01-01

    det gode liv er i stigende grad blevet en central del af genren i dag, hvor særligt kogebogsforfatternes privatliv og livsstil – altså et selvbiografisk element – er blevet et bærende narrativ i mange kogebøger. Med sådanne iscenesættelser og dramatiseringer af forestillinger om det gode liv bevæger...... den gode sags tjeneste først og fremmest tjener til at skabe et positivt billede af tv-kokken/kogebogsforfatteren som etisk individ (og brand) på bekostning af de gastronomisk nødstedte. Det skal nævnes, at jeg i min læsning af Jamies kogebogs-kampskrift har ladet mig inspirere af den russisk...

  19. Dens Evaginatus: A Problem-Based Approach

    Directory of Open Access Journals (Sweden)

    A. Ayer

    2015-01-01

    Full Text Available Dens evaginatus is an uncommon developmental anomaly of human dentition characterized by the presence of tubercle on the occlusal surface of mandibular premolars and lingual surface of anterior teeth. Due to occlusal trauma this tubercle tends to fracture thus exposing the pathway to the pulp chamber of teeth. This case report is about the presentation of dens evaginatus in mandibular premolars bilaterally; among them tooth 44 was associated with chronic apical periodontitis. Fractured tubercle of three premolars was sealed with composite resin. Root canal treatment was performed with tooth 44. Routine endodontic treatment did not result in remission of infection. Therefore, culture and sensitivity tests were performed to identify the cause and modify treatment plan accordingly. Triple antibiotic paste was used as an intracanal medicament to disinfect the root canal that resulted in remission of infection.

  20. Dens invaginatus: A review and case series

    Directory of Open Access Journals (Sweden)

    Nesrine Tebbeb

    2018-01-01

    Full Text Available Dens invaginatus (DI (dens in dente is a developmental anomaly resulting from an invagination in part of variable depth of the enamel organ into the dental papilla in the surface of the crown before calcification of the dental tissues. This anomaly usually involves the upper lateral incisors. These teeth are frequently expressed by an unusual form of crown and accentuation in the cingulum or a cusp. They are a target for caries leading to pulp necrosis and apical pathosis, so the diagnosis and early prevention measures are important. When treatment is necessary, conservative, endodontic, and periodontal possibilities are very effective. Surgical interventions are only rarely indicated. The present paper deals with the treatment of series cases with DI.

  1. Stephen Schwartz og den folkelige lyd

    DEFF Research Database (Denmark)

    Kreutzfeldt, Jacob

    2013-01-01

    Stephen Schwartz døde i foråret 2013. I denne artikel forsøger Jacob Kreutzfeldt, der gennemførte en række interviews med Schwartz gennem hans sidste år, at indkredse den æstetiske grundholdning, der prægede hans arbejde med radiomontagen i DR.......Stephen Schwartz døde i foråret 2013. I denne artikel forsøger Jacob Kreutzfeldt, der gennemførte en række interviews med Schwartz gennem hans sidste år, at indkredse den æstetiske grundholdning, der prægede hans arbejde med radiomontagen i DR....

  2. Den Digital Kirkegårdskultur

    DEFF Research Database (Denmark)

    Sabra, Jakob Borrits

    2016-01-01

    (primært vestlige) forskningslitteratur på området, vil jeg i denne artikel argumentere for, at kirkegården også har en voksende digital dimension, der kræver opmærk- somhed, holdningsudveksling og stillingtagen på samme vis som stedets religiøse, sekulære, æstetiske, sociale, kulturelle, historiske......, politiske og funktionelle dimensioner. Det for- udsætter et overblik over digitale fænomener og tendenser indenfor medieringer af døden i den danske kirkegårds- og mindekultur. Jeg vil således først give eksempler på, hvor- dan digitale teknologier og sociale medier kommer til udtryk i denne sammenhæng, og...

  3. Necrotizing enterocolitis. New thoughts about pathogenesis and potential treatments.

    Science.gov (United States)

    MacKendrick, W; Caplan, M

    1993-10-01

    Necrotizing enterocolitis (NEC) remains a major cause of morbidity and mortality in premature infants. An incomplete understanding of its pathogenesis has hampered efforts to devise an effective preventative strategy. New insights into the pathogenesis of NEC, particularly at the cellular and biochemical level, however, offer a rational basis for the development of new approaches to this disease.

  4. Open Access og Den Bibliometriske Forskningsindikator

    DEFF Research Database (Denmark)

    Dorch, Bertil

    2011-01-01

    I sine "Anbefalinger til implementering af Open Access i Danmark" foreslår det nationale Open Access Udvalget blandet andet, at Den Bibliometriske Forskningsindikator (BFI) bør koordineres med en national Open Access-politik. I dette paper, der er baseret på et blogindlæg, fremfører forfatteren...... fire grunde til, hvorfor han synes det er en dårlig idé at koble Open Access til BFI....

  5. Trichomonas vaginalis Pathogenesis: a Narrative Review

    Directory of Open Access Journals (Sweden)

    Zahra Arab-Mazar

    2015-07-01

    Full Text Available In the latest articles which were published during 2013-2014, Trichomonas vaginalis (T. vaginalis was mentioned as a neglected sexual transmission disease (STD, while the exact mechanism of its pathogenesis has not been cleared yet. Although trichomonasiasis is easy curable, there is concern that resistance to drug are increasing. This common infection as concerning the important public health implications needs more research to be done for understanding the diagnosis, treatment, immunology and pathogenesis. In this review we searched all valuable and relevant information considering the pathogenesis of T. vaginalis. We referred to the information databases of Medline, PubMed, Scopus and Google scholar. The used keywords were the combinations of T. vaginalis and words associated with pathogenicity. This review discusses the host-parasite interaction and pathogenicity of this parasite.

  6. The pathogenesis of cardiac fibrosis.

    Science.gov (United States)

    Kong, Ping; Christia, Panagiota; Frangogiannis, Nikolaos G

    2014-02-01

    Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions. This review discusses the cellular effectors and molecular pathways implicated in the pathogenesis of cardiac fibrosis. Although activated myofibroblasts are the main effector cells in the fibrotic heart, monocytes/macrophages, lymphocytes, mast cells, vascular cells and cardiomyocytes may also contribute to the fibrotic response by secreting key fibrogenic mediators. Inflammatory cytokines and chemokines, reactive oxygen species, mast cell-derived proteases, endothelin-1, the renin/angiotensin/aldosterone system, matricellular proteins, and growth factors (such as TGF-β and PDGF) are some of the best-studied mediators implicated in cardiac fibrosis. Both experimental and clinical evidence suggests that cardiac fibrotic alterations may be reversible. Understanding the mechanisms responsible for initiation, progression, and resolution of cardiac fibrosis is crucial to design anti-fibrotic treatment strategies for patients with heart disease.

  7. Pathogenesis of Idiopathic Pulmonary Fibrosis

    Science.gov (United States)

    Wolters, Paul J.; Collard, Harold R.; Jones, Kirk D.

    2014-01-01

    Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial lung disease associated with aging that is characterized by the histopathological pattern of usual interstitial pneumonia. Although an understanding of the pathogenesis of IPF is incomplete, recent advances delineating specific clinical and pathologic features of IPF have led to better definition of the molecular pathways that are pathologically activated in the disease. In this review we highlight several of these advances, with a focus on genetic predisposition to IPF and how genetic changes, which occur primarily in epithelial cells, lead to activation of profibrotic pathways in epithelial cells. We then discuss the pathologic changes within IPF fibroblasts and the extracellular matrix, and we conclude with a summary of how these profibrotic pathways may be interrelated. PMID:24050627

  8. Construindo um Densímetro

    Directory of Open Access Journals (Sweden)

    Ricetti Rodrigo

    2002-01-01

    Full Text Available Para fins didáticos, é apresentada uma maneira de construir um densímetro, aparelho utilizadopara medir a densidade de fluidos. um aparato fácil de ser construído e muito simples de serutilizado. Sua principal vantagem sobre os densímetros que comercialmente encontramos, é a suacapacidade de medir a densidade de quaisquer líquidos, operando em qualquer faixa de densidade. Outra vantagem que apresenta, é a possibilidade de fazer uma medição relativa entre quaisquerlíquidos, não fazendo apenas a medição relativa à densidade da água. Desta maneira, pode-semedir, por exemplo, a densidade do mercúrio em relação ao éter, com este instrumento. Nota-seque, desta maneira, com apenas um instrumento determina-se a densidade de qualquer líquido, nãosendo necessário dispor-se de densímetros que operem em diversas faixas de densidade, como é ocaso dos instrumentos encontrados comercialmente.

  9. Simultaneous Occurrence of Dens Invaginatus and Fusion

    Directory of Open Access Journals (Sweden)

    Amit Mhapuskar

    2013-01-01

    Full Text Available Although Dens invaginatus and fusion are well-known and well established dental anomalies, they are rarely seen in supernumerary teeth. In this article, simultaneous occurrence of Dens invaginatus and fusion between maxillary lateral incisor and a supernumerary tooth is described. Dens invaginatus is clinically significant due to the possibility of the pulpal involvement; pulpitis, necrotic pulps and chronic periapical lesions are often associated with this anomaly without clinical symptoms. Fusion has a negative impact on the aesthetics, especially when it occurs in maxillary anterior teeth. It is difficult to clinically make differential diagnosis between fused teeth and geminated teeth, especially when these anomalies take place together with hypodontia or supernumerary tooth. It has been found that sequel of such teeth may result in delayed eruption, ectopic eruption or even impaction of permanent teeth; hence proper diagnosis by clinical and radiographic methods and intervention at appropriate time is of paramount importance. The accurate knowledge of variations in morphology of tooth and pulp cavity greatly assists the dentist in planning successful treatment options.

  10. Complement and Viral Pathogenesis

    Science.gov (United States)

    Stoermer, Kristina A.; Morrison, Thomas E.

    2011-01-01

    The complement system functions as an immune surveillance system that rapidly responds to infection. Activation of the complement system by specific recognition pathways triggers a protease cascade, generating cleavage products that function to eliminate pathogens, regulate inflammatory responses, and shape adaptive immune responses. However, when dysregulated, these powerful functions can become destructive and the complement system has been implicated as a pathogenic effector in numerous diseases, including infectious diseases. This review highlights recent discoveries that have identified critical roles for the complement system in the pathogenesis of viral infection. PMID:21292294

  11. Diagnosis and clinical significance of dens invaginatus to practicing dentist.

    Science.gov (United States)

    Mupparapu, Muralidhar; Singer, Steven R; Pisano, Dominic

    2006-01-01

    Dens invaginatus, commonly known as dens in dente, is a developmental malformation of teeth that most commonly affects permanent maxillary lateral incisors. Deciduous teeth are infrequently affected. Presence of dens invaginatus in mandibular permanent teeth is extremely uncommon. A rare presentation of coronal double dens invaginatus incidentally detected in a mandibular canine tooth on radiographic examination is being reported, along with a discussion of this anomaly. The patient had presented for routine dental treatment unrelated to this finding. In addition, the various radiographic appearances of dens invaginatus, as they present within the maxillary and mandibular teeth, are described. Essential clinical considerations and treatment options are presented. A review of the pertinent literature is undertaken, and tables summarizing previously published reports of mandibular dens invaginatus and double dens invaginatus are presented. A review of the literature indicates that dens invaginatus in mandibular teeth is extremely rare, with only 11 other cases, involving 14 teeth, reported previously. Cases of double dens invaginatus are even more atypical, with only eight previously reported cases. Dens invaginatus is an anomaly that should be familiar to all practicing dentists because of the clinical implications and potential sequelae.

  12. Dens evaginatus and dens invaginatus in a double tooth: A rare case report

    Directory of Open Access Journals (Sweden)

    Gaurav Sharma

    2015-01-01

    Full Text Available The presence of dens invaginatus (DI and dens evaginatus (DE on same tooth is a rare phenomenon. However, when these dental anomalies occur on a double tooth, it becomes an extremely rare phenomenon. The authors report a rare case of DI and DE on fused permanent maxillary central incisor with supernumerary tooth in a 40-year-old male. The present article also focuses on the differentiating fusion from gemination and also reviews preventive and management strategies for tooth with complex dental anatomy.

  13. Immunological pathogenesis of inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    Seung Hoon Lee

    2018-01-01

    Full Text Available Inflammatory bowel disease (IBD is a chronic inflammatory state of the gastrointestinal tract and can be classified into 2 main clinical phenomena: Crohn's disease (CD and ulcerative colitis (UC. The pathogenesis of IBD, including CD and UC, involves the presence of pathogenic factors such as abnormal gut microbiota, immune response dysregulation, environmental changes, and gene variants. Although many investigations have tried to identify novel pathogenic factors associated with IBD that are related to environmental, genetic, microbial, and immune response factors, a full understanding of IBD pathogenesis is unclear. Thus, IBD treatment is far from optimal, and patient outcomes can be unsatisfactory. As result of massive studying on IBD, T helper 17 (Th17 cells and innate lymphoid cells (ILCs are investigated on their effects on IBD. A recent study of the plasticity of Th17 cells focused primarily on colitis. ILCs also emerging as novel cell family, which play a role in the pathogenesis of IBD. IBD immunopathogenesis is key to understanding the causes of IBD and can lead to the development of IBD therapies. The aim of this review is to explain the pathogenesis of IBD, with a focus on immunological factors and therapies.

  14. Catalogue of polar bear (Ursus maritimus) maternal den locations in the Beaufort Sea and neighboring regions, Alaska, 1910-2010

    Science.gov (United States)

    Durner, George M.; Fischbach, Anthony S.; Amstrup, Steven C.; Douglas, David C.

    2010-01-01

    This report presents data on the approximate locations and methods of discovery of 392 polar bear (Ursus maritimus) maternal dens found in the Beaufort Sea and neighboring regions between 1910 and 2010 that are archived by the U.S. Geological Survey, Alaska Science Center, Anchorage, Alaska. A description of data collection methods, biases associated with collection method, primary time periods, and spatial resolution are provided. Polar bears in the Beaufort Sea and nearby regions den on both the sea ice and on land. Standardized VHF surveys and satellite radio telemetry data provide a general understanding of where polar bears have denned in this region over the past 3 decades. Den observations made during other research activities and anecdotal reports from other government agencies, coastal residents, and industry personnel also are reported. Data on past polar bear maternal den locations are provided to inform the public and to provide information for natural resource agencies in planning activities to avoid or minimize interference with polar bear maternity dens.

  15. An update on the diagnosis and treatment of dens invaginatus.

    Science.gov (United States)

    Zhu, J; Wang, X; Fang, Y; Von den Hoff, J W; Meng, L

    2017-09-01

    Dens invaginatus is a malformation with varying anatomical features, posing challenges to treatment. Early and accurate diagnosis plays a significant role in selecting the appropriate treatment. The diagnosis of teeth with a complex root canal system including dens invaginatus has made progress with the application of three-dimensional imaging techniques in endodontics. Advanced treatment options provide hope for teeth that could not be saved before. This review discusses diagnostic methods and treatment options for teeth with dens invaginatus, and provides guidelines for the management of dens invaginatus cases in clinic. Current as well as traditional diagnostic techniques are summarized. Treatment options including state-of-the-art alternatives are presented for coronal dens invaginatus and radicular dens invaginatus. © 2017 Australian Dental Association.

  16. Pathogenesis of Candida infections.

    Science.gov (United States)

    Odds, F C

    1994-09-01

    Candida infections of the skin and superficial mucosal sites are the result of an interplay between fungal virulence and host defenses. Epidermal proliferation and T-lymphocyte immune responses are expressed by the host to combat fungal invasion, but inflammatory responses and nonspecific inhibitors also probably play a role. Candida albicans can express at least three types of surface adhesion molecules to colonize epithelial surfaces, plus an aspartyl proteinase enzyme able to facilitate initial penetration of keratinized cells. Deeper penetration of keratinized epithelia is assisted by hypha formation, and C. albicans hyphae may use contact sensing (thigmotropism) as a guiding mechanism. Pathogenesis requires differential expression of virulence factors at each new stage of the process: a propensity for rapid alteration of the expressed phenotype in C. albicans may therefore be a significant factor in establishing the comparatively high pathogenic potential of this species.

  17. Droht den "kleinen Sprachen" das Aussterben?

    Directory of Open Access Journals (Sweden)

    Anita Lemić

    2014-12-01

    Full Text Available Die Prozesse der Globalisierung sind die Ursache für viele Änderungen in der Weltgemeinschaft, vor allem die Entfernung von Unterscheidungsmerkmalen (in Bezug darauf, dass „zwischen vielen ethnischen Zeichen, das was dauernd ist, ist die Dichotomisierung/Differenzierung eines „Wir-und-die-Anderen“ (Grbić, 2003, 93-64. Diese Zeichen wirken als Zeichen der Resozialisierung, die die bestehenden Identitäten löschen und sich an der Schaffung neuer Strukturen beteiligen. Die Zeit der Romantik in Europa ermöglichte die Schaffung von Nationalstaaten und ihr Hauptmerkmal war die Nationalsprache. Diese Art der sozialen Differenzierung hatte das Ziel, die Illusion einer vollständig homogenisierten Gesellschaft zu schaffen und damit den Prozess der Zerstörung der „kleinen“ Sprachen zu beginnen. Sprache und Kultur erwiesen sich als Grundlage der Gemeinschaftserhaltung. Die Homogenisierung ermöglicht Aktivitäten mit dem Ziel, einem Individuum zu helfen, sich als Individuum und als Mitglied der Gemeinschaft zu behaupten. Keine dieser beiden Identitäten kann ohne die Wechselwirkung mit der Umgebung erreicht werden. Die sprachliche Interaktion mit anderen Mitgliedern ist das Schlüsselsegment, das Menschen von anderen Lebensformen unterscheidet. Durch den Austausch von Erfahrungen mit anderen kommt der Mensch auf allen Ebenen voran und mit der Erfindung der Schrift öffnete er die Tür zur Entwicklung der Zivilisation. In dieser Arbeit beschäftigen wir uns mit der Frage der „Prestige“-Sprachen, die auf der Grundlage der Macht der Gemeinschaft der Muttersprachler ihren Bereich weit über die Grenzen des eigenen Landes hinaus erweitern und so eine politische und wirtschaftliche Vormachtstellung schaffen, aber auch mit den Auswirkungen jener Sprachen auf die Dekonstruktion oder möglicherweise vollständige Ausrottung der Sprachen, die auf diese Weise an Einfluss verlieren, unmodern werden und sich die Frage der Notwendigkeit ihrer

  18. Den teoretiske udvikling af Supply Chain Strategimodeller

    DEFF Research Database (Denmark)

    Arvad Johansen, Jens

    2011-01-01

    segmentering via postponement-princippet, har givet mærkbare forbedringer. Det beskrives endvidere, hvordan produkternes livscyklus påvirker valget af supply chain design. Begrebet Demand Chain Management( DCM), hvormed strategimodeller bruger klassiske marketingelementer sammen med Supply Chain Management......Denne artikel beskriver med udgangspunkt i artikler og virksomhedseksempler udviklingen inde for supply chain strategimodeller. Ved hjælp af tidligere udviklede koncepter besvares spørgsmålet: “Hvad er den rette supply chain for mine produkter?”. Virksomhedseksempler beskriver, hvordan supply chain...

  19. Zoologien i den klassiske islamiske kultur

    OpenAIRE

    Provencal, Philippe; Aarab, Ahmed

    2014-01-01

    Denne artikel bringer en oversigt over forskning i den zoologiske videnskab, således som denne er kommet til udtryk i tekster skrevet på klassisk arabisk fra anden halvdel af 700-tallet til 1400-tallet. I lyset af nyere forskning og med eksempler hentet fra de arabiske tekster selv, bliver en ny bedømmelse af disse teksters faglige indhold foreslået. This article brings a survey of research on the science of zoology in the Classical Arabic/Islamic Culture as revealed in texts on this subje...

  20. Zu den on Emona und Ljubljana

    Directory of Open Access Journals (Sweden)

    Jaroslav Šašel

    1984-12-01

    Full Text Available Die Bildungssilbe -ona wurde in übernommenen ON von den Slawen regelmässig auf -in umgebildet (Salona-Solin. Dieser Gruppe wird vom Autor auch die Form Atamine beigezählt (für Emona, Anon. Ravenn. 4.20, die infolge einer Diskontinuität in Vergessenheit geriet. Im Bereich derselben Siedlungsstelle taucht später der ON Ljubljana auf, dessen Bildungssilbe -ana (wie in ON Fažana, Sežana auf lokales Bestehen eines sprachlich vorslawischen Elements hindeutet. Lit. und Beispiele s. im Text oben.

  1. [Dens in dente. Histological characteristics of an unusual case of dens in dente].

    Science.gov (United States)

    Macorra, J C; Pérez, J; Puertas, A J

    1989-03-01

    We describe a rare case of "dens in dente" in an accessory germ in central location of an anencephalic phoetus. Its characteristics of having enamel surrounding normal dentin and normal pulpar cavity, all of them surrounded by the unaffected accessory germ leads us to describe the term "dente in dente". Such alteration is not previously described.

  2. Den skjulte Oldtid – den nye udstilling på Nationalmuseet

    DEFF Research Database (Denmark)

    Ingemann, Bruno

    2009-01-01

    Enhver udstilling konstruerer sin besøgende! Man skal som besøgende have bestemte forudsætninger, en vis viden, kende bestemte kategorier, have en bestemt form for nysgerrighed – og det er udstillingen som skaber dette særsprog med dets muligheder for at udelukke eller inkludere den besøgende. De...

  3. The incidence of the dens invaginatus in the maxillary incisors

    International Nuclear Information System (INIS)

    Jin, Hae Yun; Lee, Sang Rae

    1980-01-01

    The purpose of this survey was to reveal a incidence of dens invaginatus in the maxillary incisor region. The material was 1671 sets of full mouth intraoral standard films, which was taken from the patients visiting for the routine check at the Infirmary of College of Dentistry, Kyung Hee University. The following results were obtained; 1. The incidence of dens invaginatus was 14.90 and that of slightly dilated dens invaginatus was 9.46%. 2. The incidence of dens invaginatus showed no difference between male and female. 3. Most of the dens invaginatus occurred in the maxillary lateral incisors (93.53%) and a few in the maxillary central incisors (6.46%) showed slight invagination. 4. Among the cases with dens invaginatus, over a half (53.41%) showed bilateral occurrence. 5. Comparatively rate cases, i. e. bilateral dens invaginatus of the maxillary central incisors, unilateral double dens invaginatus of the maxillary lateral incisor, and bilateral dens invaginatus of the maxillary lateral incisors, one side double and one side single, were reported.

  4. The incidence of the dens invaginatus in the maxillary incisors

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Hae Yun; Lee, Sang Rae [Dept. of Dental Radiology, Division of Dentistry, Graduate School, Kyung Hee University, Seoul (Korea, Republic of)

    1980-11-15

    The purpose of this survey was to reveal a incidence of dens invaginatus in the maxillary incisor region. The material was 1671 sets of full mouth intraoral standard films, which was taken from the patients visiting for the routine check at the Infirmary of College of Dentistry, Kyung Hee University. The following results were obtained; 1. The incidence of dens invaginatus was 14.90 and that of slightly dilated dens invaginatus was 9.46%. 2. The incidence of dens invaginatus showed no difference between male and female. 3. Most of the dens invaginatus occurred in the maxillary lateral incisors (93.53%) and a few in the maxillary central incisors (6.46%) showed slight invagination. 4. Among the cases with dens invaginatus, over a half (53.41%) showed bilateral occurrence. 5. Comparatively rate cases, i. e. bilateral dens invaginatus of the maxillary central incisors, unilateral double dens invaginatus of the maxillary lateral incisor, and bilateral dens invaginatus of the maxillary lateral incisors, one side double and one side single, were reported.

  5. Mozart, Karl Barth, og den kristne troslæren

    DEFF Research Database (Denmark)

    Petersen, Nils Holger

    2010-01-01

    En diskussion af Karl Barths teologiske brug af W.A.Mozart i den kirchliche Dogmatik med kontekstuel inddragelse af en til en vis grad tilsvarende overordnet diskussion af Mozart, skrevet af en samtidig musiker, den fremtrædende Mozart-dirigent Ferenc Fricsay. ......En diskussion af Karl Barths teologiske brug af W.A.Mozart i den kirchliche Dogmatik med kontekstuel inddragelse af en til en vis grad tilsvarende overordnet diskussion af Mozart, skrevet af en samtidig musiker, den fremtrædende Mozart-dirigent Ferenc Fricsay. ...

  6. The Dens: Normal Development, Developmental Variants and Anomalies, and Traumatic Injuries

    Directory of Open Access Journals (Sweden)

    William T O′Brien

    2015-01-01

    Full Text Available Accurate interpretation of cervical spine imagining can be challenging, especially in children and the elderly. The biomechanics of the developing pediatric spine and age-related degenerative changes predispose these patient populations to injuries centered at the craniocervical junction. In addition, congenital anomalies are common in this region, especially those associated with the axis/dens, due to its complexity in terms of development compared to other vertebral levels. The most common congenital variations of the dens include the os odontoideum and a persistent ossiculum terminale. At times, it is necessary to distinguish normal development, developmental variants, and developmental anomalies from traumatic injuries in the setting of acute traumatic injury. Key imaging features are useful to differentiate between traumatic fractures and normal or variant anatomy acutely; however, the radiologist must first have a basic understanding of the spectrum of normal developmental anatomy and its anatomic variations in order to make an accurate assessment. This review article attempts to provide the basic framework required for accurate interpretation of cervical spine imaging with a focus on the dens, specifically covering the normal development and ossification of the dens, common congenital variants and their various imaging appearances, fracture classifications, imaging appearances, and treatment options.

  7. Digital kommunikation med den offentlige sektor

    DEFF Research Database (Denmark)

    Berger, Jesper; Andersen, Kim Normann

    2013-01-01

    til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs. uden at uvedkommende kan få adgang til...... følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Undersøgelsen medtager myndighedernes besvarelse af digital post og e-mail, dels for at kunne...... sammenligne de to digitale kanaler og for at kunne sammenligne med en tidligere undersøgelse af digital kommunikation med det offentlige. Herudover er der tidligere gennemført en undersøgelse af e-mail svar og svartider i New Zealand og Australien. De danske resultater fra e-mail undersøgelsen, men ikke...

  8. Digital kommunikation med den offentlige sektor

    DEFF Research Database (Denmark)

    Berger, Jesper Bull; Andersen, Kim Normann

    digital postkasse, som borgerne kunne skrive til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs....... uden at uvedkommende kan få adgang til følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Vi har også undersøgt besvarelse af e-mail, dels...... for at kunne sammenligne de to digitale kanaler og for at kunne sammenligne med en tidligere undersøgelse af digital kommunikation med det offentlige. Herudover er der tidligere gennemført en undersøgelse af e-mail svar og svartider i New Zealand og Australien. De danske resultater fra e-mail undersøgelsen...

  9. Digital kommunikation med den offentlige sektor

    DEFF Research Database (Denmark)

    Berger, Jesper Bull; Andersen, Kim Normann

    til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs. uden at uvedkommende kan få adgang til...... følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Undersøgelsen medtager myndighedernes besvarelse af digital post og e-mail, dels for at kunne...... sammenligne de to digitale kanaler og for at kunne sammenligne med en tidligere undersøgelse af digital kommunikation med det offentlige. Herudover er der tidligere gennemført en undersøgelse af e-mail svar og svartider i New Zealand og Australien. De danske resultater fra e-mail undersøgelsen, men ikke...

  10. Philipp van den Bossche – Sac. Caes. Mai. Phrygiarius

    Czech Academy of Sciences Publication Activity Database

    Bukovinská, Beket

    -, č. 0130 (2015), s. 1-18 ISSN 2190-3328 Institutional support: RVO:68378033 Keywords : Philipp van den Bossche * Prague court * Rudolph II * Kunstkammer Subject RIV: AL - Art, Architecture, Cultural Heritage http://www.riha-journal.org/articles/2015/2015-oct-dec/bukovinska-philipp-van-den-bossche

  11. ICC2007 i Moskva, den 23. internationale kartografikongres

    DEFF Research Database (Denmark)

    Brodersen, Lars

    2007-01-01

    1200 deltagere fra hele verden var samlet i dagene 4. til 9. august 2007 i Moskva for at afholde den 23. internationale kartografikongres. Udgivelsesdato: september......1200 deltagere fra hele verden var samlet i dagene 4. til 9. august 2007 i Moskva for at afholde den 23. internationale kartografikongres. Udgivelsesdato: september...

  12. Empirisme, rationalisme og den moralske følelse

    DEFF Research Database (Denmark)

    Nielsen, Carsten Fogh

    2003-01-01

    Sammenlignende diskussion af David Humes og Immanuel Kants syn på følelsernes rolle for den moralske dom......Sammenlignende diskussion af David Humes og Immanuel Kants syn på følelsernes rolle for den moralske dom...

  13. Laika – den første hund i rummet

    DEFF Research Database (Denmark)

    Alstrup, Aage Kristian Olsen

    2013-01-01

    DETTE ER DEN FØRSTE ARTIKEL I EN SERIE OM FORSØGSDYRENES ROLLE I RUMFORSKNINGEN. DYRENE SPILLEDE EN CENTRAL ROLLE I RUSSERNES OG AMERIKANERNES RUMKAPLØB UNDER DEN KOLDE KRIG. I DAG BRUGES DYRENE TIL MEDICINSKE FORSØG UDFØRT I VÆGTLØS TILSTAND. FØRSTE ARTIKEL HANDLER OM GADEKRYDSET LAIKA, SOM BLEV...

  14. Trump, NATO og den europæiske sikkerhedsarkitektur

    DEFF Research Database (Denmark)

    Ringsmose, Jens; Henriksen, Anders

    Manglende klarhed i den amerikanske linje over for det NATO, landet indtil nu har taget føringen i, vil få konsekvenser for Europa og for Danmarks muligheder og valg. Denne rapport ser på konsekvenserne for den europæiske sikkerhedsarkitektur....

  15. "Den lille havfrue" som digital pop op-bog

    DEFF Research Database (Denmark)

    Mygind, Sarah

    2017-01-01

    Anmeldelse af: DIGITAL POP OP-BOG H. C. ANDERSEN OG BOOKS & MAGIC DEN LILLE HAVFRUE Bog og App til iOS & Android 5......Anmeldelse af: DIGITAL POP OP-BOG H. C. ANDERSEN OG BOOKS & MAGIC DEN LILLE HAVFRUE Bog og App til iOS & Android 5...

  16. A rare presentation of multiple dens invaginatus in maxillary dentition.

    Science.gov (United States)

    Purani, Jigar M; Purani, Hiral J

    2014-08-01

    Dens invaginatus is a developmental disturbance of the tooth and usually occurs in the maxillary lateral incisor of permanent dentition. In this article, a rare case of dens invaginatus affecting multiple permanent maxillary teeth is described. 2014 BMJ Publishing Group Ltd.

  17. Facial cellulitis secondary to dens invaginatus: a case report.

    Science.gov (United States)

    Arsenault, Murielle; Anderson, Ross D; Dyment, Heather; MacLellan, Jennifer; Doyle, Tracy

    2011-04-01

    We describe a case of dens invaginatus in an unerupted permanent maxillary lateral incisor, which led to facial cellulitis in a 10-year-old girl. We review the importance of recognizing dens invaginatus and present strategies for preventing loss of vitality in the affected tooth.

  18. An update on the diagnosis and treatment of dens invaginatus

    NARCIS (Netherlands)

    Zhu, J.; Wang, X.; Fang, Y.; Hoff, J.W. Von den; Meng, L.

    2017-01-01

    Dens invaginatus is a malformation with varying anatomical features, posing challenges to treatment. Early and accurate diagnosis plays a significant role in selecting the appropriate treatment. The diagnosis of teeth with a complex root canal system including dens invaginatus has made progress with

  19. Den Ontologiske Vending i Antropologi og Science and Technology Studies

    DEFF Research Database (Denmark)

    Winthereik, Brit Ross

    2015-01-01

    Formålet med artiklen er at afsøge, hvad videnskabs- og teknologi- studier eller Science and Technology Studies (STS) tilbyder humaniora og samfundsvidenskaberne med det nybrud, der er blevet kaldt den ontologiske vending. Med udgangspunkt i en beskrivelse af den onto- logiske vending i antropologi...

  20. Pathogenesis of rhinitis.

    Science.gov (United States)

    Eifan, A O; Durham, S R

    2016-09-01

    Rhinitis is a heterogeneous condition that has been associated with inflammatory responses as in allergic rhinitis but can also occur in the absence of inflammation such as in so-called idiopathic (previously 'vasomotor') rhinitis. Allergic rhinitis affects approximately one in four of the population of westernized countries and is characterized by typical symptoms of nasal itching, sneezing, watery discharge and congestion. The intention of this review is to illustrate key concepts of the pathogenesis of rhinitis. Imbalance in innate and adaptive immunity together with environmental factors is likely to play major roles. In allergic rhinitis, initial allergen exposure and sensitization involves antigen-presenting cells, T and B lymphocytes and results in the generation of allergen-specific T cells and allergen-specific IgE antibodies. On re-exposure to relevant allergens, cross-linking of IgE on mast cells results in the release of mediators of hypersensitivity such as histamine and immediate nasal symptoms. Within hours, there is an infiltration by inflammatory cells, particularly Th2 T lymphocytes, eosinophils and basophils into nasal mucosal tissue that results in the late-phase allergic response. Evidence for nasal priming and whether or not remodelling may be a feature of allergic rhinitis will be reviewed. The occurrence of so-called local allergic rhinitis in the absence of systemic IgE will be discussed. Non-allergic (non-IgE-mediated) rhinitis will be considered in the context of inflammatory and non-inflammatory disorders. © 2016 John Wiley & Sons Ltd.

  1. Konservatismen og den højreradikale terror

    DEFF Research Database (Denmark)

    Skov, Christian Houlberg

    2011-01-01

    Den norske højreekstremist Anders Behring Breiviks terror mod det norske samfund har herhjemme ledt til en voldsom debat om blandt andet forbindelsen mellem tonen i debatten og terrorangrebet og forholdet mellem den siden 2001 meget omtalte kulturkonservatisme og Anders Breiviks terrorhandling....... Essayet Konservatismen og den højreradikale terror forsøger dels at skabe klarhed over fronterne i debatten, dels at rette en kritik mod såvel tendensen til at afskrive handlingen som uforståelig som af tendensen til at slå den bredere højrefløjs kritik af multikulturalismen i hartkorn med Breiviks...... højreradikalisme. Artiklen forsøger at vise skellet mellem et konservativ og et højreradikalt ideologisk udgangspunkt, samtidig med, at den fastholder, at konservative ikke per definition er immune over for radikalisering....

  2. Guide til evaluering af Den motiverende samtale

    DEFF Research Database (Denmark)

    Lunde, Anita; Douw, Karla

    UC Lillebælt har på baggrund af kommunale henvendelser udarbejdet et kursusforløb om Den motiverende samtale (DMS). I en efterfølgende evaluering af forløbet har en nedsat projektgruppe udarbejdet en guide til selvevaluering med fokus på kompetenceudvikling af kursusdeltagerne. For at sikre...... dog også andre kommunikationsmodeller, og DMS indgår i fragmenter. Det er særligt delen om ambivalens og forandringshjulet der fremhæves fra DMS. Evalueringen af SEG peger på følgende: Selvevaluering er mest meningsfyldt, når DMS jævnligt anvendes, hvorfor målgruppen for SEG med fordel kan beskrives...

  3. dens dualitet – ‘den gode død’ og ‘den dårlige død’

    DEFF Research Database (Denmark)

    Jacobsen, Michael Hviid; Dalgaard, Karen Marie; Wanseele, Janet Ferrari

    2013-01-01

    Abstract dansk: Igennem de seneste årtier har forestillinger om ‘den gode død’ været en vigtig drivkraft i og inspirationskilde for palliative praksis. I denne artikel argumenterer forfatterne for, at man kan begynde at se konturerne af en skifte væk fra en ensidig fokusering på ’den gode død’ og...

  4. Den portugisiske koloniserings mange stemmer. António Lobo Antunes

    DEFF Research Database (Denmark)

    Larsen, Ingemai

    2007-01-01

    Artiklen analyserer to af den portugisiske forfatter Antonio Lobo Antunes bedst kendte værker og viser hvorledes den portugisiske kolonisering med dens mange ambivalenser og 'stemmer' her italesættes.......Artiklen analyserer to af den portugisiske forfatter Antonio Lobo Antunes bedst kendte værker og viser hvorledes den portugisiske kolonisering med dens mange ambivalenser og 'stemmer' her italesættes....

  5. Kosmetisk kirurgi og den transformérbare krop -en analyse af den amerikanske tv-serie Nip/Tuck

    DEFF Research Database (Denmark)

    Jerslev, Anne

    2009-01-01

    En analyse af krops- og kønsiscenesættelser i den amerikanske tv-serie om kosmetisk kirurgi Nip/Tuck......En analyse af krops- og kønsiscenesættelser i den amerikanske tv-serie om kosmetisk kirurgi Nip/Tuck...

  6. Early morphogenesis of the sinuatrial region of the chick heart: a contribution to the understanding of the pathogenesis of direct pulmonary venous connections to the right atrium and atrial septal defects in hearts with right isomerism of the atrial appendages.

    Science.gov (United States)

    Männer, Jörg; Merkel, Nico

    2007-02-01

    The morphogenesis of the sinuatrial region of embryonic hearts is still not well understood. Current matters of dispute are the topogenesis of the future pulmonary vein orifice and the topogenesis of the primary atrial septum. We analyzed the development of the sinuatrial region in chick embryos ranging from Hamburger and Hamilton (HH) stage 14 to 25. Our study disclosed three features of sinuatrial development. First, the primitive atrium of the HH stage 16 chick embryo heart has a separate inflow component. This inflow component takes up the mouth of the confluence of the systemic veins (sinus venosus) as well as the future mouth of the common pulmonary vein (pulmonary pit). The left portion of the atrial inflow component becomes incorporated into the left atrium and its right portion becomes incorporated into the right atrium. Rightward growth of the sinuatrial fold separates the sinus venosus from the left atrium. Second, the pulmonary pit originally forms as a bilaterally paired structure. Its left and right portions are connected to the left and right portions of the atrial inflow component, respectively. Normally, only the left portion of the pulmonary pit deepens to form the common pulmonary vein orifice, whereas the right portion disappears. Third, the primary atrial septum of the chick heart is not formed at the original midline of the embryonic heart, but is formed to the left of the original midline. This finding is in accord with molecular data suggesting that the primary atrial septum derives from the left heart-forming field. Our findings shed new light on the pathogenesis of direct pulmonary venous connections to the right atrium and atrial septal defects in hearts with right isomerism of the atrial appendages.

  7. The epigenetic paradigm in periodontitis pathogenesis

    Directory of Open Access Journals (Sweden)

    Vamsi Lavu

    2015-01-01

    Full Text Available Epigenome refers to "epi" meaning outside the "genome." Epigenetics is the field of study of the epigenome. Epigenetic modifications include changes in the promoter CpG Islands, modifications of histone protein structure, posttranslational repression by micro-RNA which contributes to the alteration of gene expression. Epigenetics provides an understanding of the role of gene-environment interactions on disease phenotype especially in complex multifactorial diseases. Periodontitis is a chronic inflammatory disorder that affects the supporting structures of the tooth. The role of the genome (in terms of genetic polymorphisms in periodontitis pathogenesis has been examined in numerous studies, and chronic periodontitis has been established as a polygenic disorder. The potential role of epigenetic modifications in the various facets of pathogenesis of periodontitis is discussed in this paper based on the available literature.

  8. Religionsvetenskapen i övergången från den första till den andra moderniteten

    DEFF Research Database (Denmark)

    Ahlin, Lars

    2009-01-01

    Den tyske sociolog Ulrich Beck er optaget af overgangen fra den første til den anden modernitet. Han argumenterer for at denne overgang fører til at sociologiske kategorier som klasse og familie bliver zombie-kategorier. Det er kategorier skabt under den første modernitet men som stadigvæk er i...... brug i dag under den anden modernitet, til trods for at de er levende døde kategorier. I denne artikel argumenters for at kategorier, begreber, brugt inden for religionsvidenskaben, primært religionssociologien, også kan betragtes som zombie-kategorier. De begreber der diskuteres er religiøse...

  9. Molecular mechanisms of rosacea pathogenesis

    Directory of Open Access Journals (Sweden)

    Davydova A.M.

    2013-09-01

    Full Text Available The article presents possible molecular mechanisms for rosacea pathogenesis from current domestic and foreign clinical observations and laboratory research: regulation and expression defects of antimicrobial peptides, vascular endothelial growth factor, the effect of serine proteases, oxidative stress, reactive oxygen species and ferritin on the occurrence and course of rosacea. New developments in molecular biology and genetics are advanced for researching the interaction of multiple factors involved in rosacea pathogenesis, as well as providing the bases for potentially new therapies.

  10. Concepts in viral pathogenesis II

    Energy Technology Data Exchange (ETDEWEB)

    Notkins, A.L.; Oldstone, M.B.A.

    1986-01-01

    This paper contains papers divided among 10 sections. The section titles are: Viral Structure and Function; Viral Constructs; Oncogenes, Transfection, and Differentiation; Viral Tropism and Entry into Cells; Immune Recognition of Viruses; Evolving Concepts in Viral Pathogenesis Illustrated by Selected Plant and Animal Models; Evolving Concepts in Viral Pathogenesis Illustrated by Selected Diseases in Humans; New Trends in Diagnosis and Epidemiology; and Vaccines and Antiviral Therapy.

  11. Endodontic management of a maxillary lateral incisor with dens invaginatus and external root irregularity using cone-beam computed tomography

    Directory of Open Access Journals (Sweden)

    Young-Jun Lim

    2012-02-01

    Full Text Available Cone-beam computed tomography (CBCT is a useful diagnostic tool for identification of both internal and external root configurations. This case report describes the endodontic management of a lateral incisor with both dens invaginatus and external root irregularity by using CBCT. Nonsurgical endodontic retreatment was performed on the lateral incisor with dens invaginatus. A perforation through the dens invaginatus and external concavity was repaired using mineral trioxide aggregate. After 18 mon of follow-up, there were no clinical symptoms. Recall radiographs appeared normal and showed healing of the periapical pathosis. The understanding of both internal root canal configuration and external root irregularity using CBCT can ensure predictable and successful results.

  12. Review: pathogenesis of gallstones.

    Science.gov (United States)

    Dowling, R H

    2000-05-01

    The aim of this article is to review selected aspects of the pathogenesis of cholesterol-rich, gall-bladder stones (GBS)--with emphasis on recent developments in biliary cholesterol saturation, cholesterol microcrystal nucleation, statis within the gall-bladder and, particularly, on the roles of intestinal transit and altered deoxycholic acid (DCA) metabolism, in GBS development. In biliary cholesterol secretion, transport and saturation, recent developments include evidence in humans and animals, that bile lipid secretion is under genetic control. Thus in mice the md-2 gene, and in humans the MDR-3 gene, encodes for a canalicular protein that acts as a 'flippase' transporting phospholipids from the inner to the outer hemi-leaflet of the canalicular membrane. In the absence of this gene, there is virtually no phospholipid or cholesterol secretion into bile. Furthermore, when inbred strains of mice that have 'lith genes' are fed a lithogenic diet, they become susceptible to high rates of GBS formation. The precipitation/nucleation of cholesterol microcrystals from supersaturated bile remains a critical step in gallstone formation. methods of studying this phenomenon have now been refined from the original 'nucleation time' to measurement of cholesterol appearance/detection times, and crystal growth assays. Furthermore, the results of recent studies indicate that, in addition to classical Rhomboid-shape monohydrate crystals, cholesterol can also crystallize, transiently, as needle-, spiral- and tubule-shaped crystals of anhydrous cholesterol. A lengthy list of promoters, and a shorter list of inhibitors, has now been defined. There are many situations where GB stasis in humans is associated with an increased risk of gallstone formation--including iatrogenic stone formation in acromegalic patients treated chronically with octreotide (OT). As well as GB stasis, however, OT-treated patients all have 'bad' bile which is supersaturated with cholesterol, has excess

  13. Man nature technology. Answers for the classroom; Mensch Natur Technik. Antworten fuer den Unterricht

    Energy Technology Data Exchange (ETDEWEB)

    Heymann, H.W.; Kattmann, U.; Otto, G.; Staeudel, L.; Weiberg, G. [eds.

    1999-06-01

    Also school and instruction are subject to global changes and at the same time a mirror image of this changing processes and even self factors influencing this changes. This brochure will demonstrate this changes in the domain of environment, energy utilization and influencing nature on criterions like: Living with nature and engineering; understanding nature and engineering; interviewing engineering and handle carfully. The single units of lessons can be excellently applied for instruction. [Deutsch] Auch Schule und Unterricht sind globalen Veraenderungen unterworfen und sind zugleich Spiegelbild dieser Veraenderungsprozesse und gleichzeitig Faktoren selbst, die die Veraenderungen beeinflussen. Aufzeigen will dies die vorliegende Broschuere im Bereich der Umwelt, Energieanwendung, Naturbeeinflussung nach den Kriterien: Mit Natur und Technik leben; Natur und Technik verstehen; Technik befragen und sorgsam handeln. Die einzelnen Beitraege lassen sich hervorragend fuer den Unterricht verwenden.(GL)

  14. Endodontic, surgical and periodontal treatment of dens invaginatus. Case report.

    Science.gov (United States)

    Castellarin, M; Demitri, V; Politi, M

    2001-01-01

    The aim of this paper is to propose a single stage global treatment of endodontic, periapical and periodontal lesions in a lateral maxillary incisor with dens invaginatus. A 24 year-old woman presenting a lateral maxillary incisor with dens invaginatus in association with periapica1 and periodontal lesions underwent simultaneous surgical, endodontic and periodontal regenerative procedures. At 2, 6, 12, 18 months follow-up the radiographic healing appeared to be improved and the periapical lesion healed completely 1 year after surgical intervention. Surgery in association with endodontic and periodontal procedures represents the treatment of choice to maximize long term prognosis in cases of dens invaginatus with chronic periapical and periodontal lesions.

  15. Radiomontagen og dens radiofoniske rødder. Om hørebilledet, den litterære tekstmontage, featuren og den moderne radiomontage

    Directory of Open Access Journals (Sweden)

    Ib Poulsen

    2001-09-01

    Full Text Available Radiomontagen og dens genrevarianter, hørebilledet og featuren har tidligere har tidligere været genstand for interesse fra især den æste- tiske og tekstanalytisk orienterede radioforskning. I denne artikel sæt- tes genren ind i en bredere kontekst, sociokulturelt og medie- og insti- tutionshistorisk. Ledetrådene i den diakrone fremstilling er dels spørgs- målet om genrens historiske og genremæssige rødder, dels en kombi- neret tekstanalytisk og receptionsæstetisk tilgang, der søger at ind- kredse de positioneringer af lytteren, radiomontagen og dens varianter tilbyder. Artiklen er baseret på grundige arkivstudier i DR og på inter- views med nogle af de ’montører’, som har bidraget til udviklingen af montagen, der i kraft af sin radiofoniske spændvidde mest vedholdende og varieret har forsøgt at udforske menneskets livssituation i den moder- ne verden, samtidig med at lytteren er blevet tilbudt en lytteposition, der prioriterer refleksion og eftertanke.

  16. An Odyssey to Viral Pathogenesis.

    Science.gov (United States)

    Oldstone, Michael B A

    2016-05-23

    This odyssey is mine from early junior high school, where my dreams for adventure were shaped by Arthur Conan Doyle's Sherlock Holmes, Percival Christopher Wren's Beau Geste, and best of all the remarkable explorers in Paul de Kruif's Microbe Hunters. My birth site was in Manhattan (my mother was a Vogue model and my father worked in retail), and I traveled to college at the University of Alabama, Tuscaloosa, where my love of history and English literature was shaped along with a sufficient exposure to biology, chemistry, and genetics to meet requirements for entering medical school. By the second year at the University of Maryland School of Medicine, through expert teachers such as Theodore (Ted) Woodward and Sheldon (Shelly) Greisman in medicine and Charles Weissmann in virology and microbiology, I found that understanding why and how people became ill was more my cup of tea than identifying and treating their illnesses. Although I was becoming competent in diagnosis and treatment, I left medical school at the end of my sophomore year to seek a more basic understanding of biology and chemistry. I achieved this by working toward a PhD in biochemistry at Johns Hopkins McCollum-Pratt Institute combined with study of rickettsial toxin at Maryland. This was a very important time in my life, because it convinced me that addressing biologic and medical questions in a disciplined scientific manner was what my life voyage should be. That voyage led me initially, through Woodward's contact, to work a summer in Joe Smadel's unit at Walter Reed (Smadel being one of the deans of American virology) and to meet several times with Carleton Gajdusek and then John Enders at Harvard, who pointed me to Frank Dixon at Scripps in La Jolla, California, for postdoctoral training. Dixon was among the founders of modern immunology and a pathfinder for immunopathology. Training by and association with Dixon and his other postdoctoral fellows, my independent position at Scripps, early

  17. Auf den Schultern von Riesen und Zwergen Einsteins unvollendete Revolution

    CERN Document Server

    Renn, Jürgen

    2006-01-01

    Dies ist die Geschichte von Einsteins unvollendeter Revolution, einer tiefgreifenden Veränderung unserer Begriffe von Raum, Zeit, Materie und Strahlung. Diese Revolution begann in Einsteins Wunderjahr 1905, wurde durch seine allgemeine Relativitätstheorie aus dem Jahre 1915 fortgesetzt und wirkt in den heutigen Versuchen der Wissenschaft, die Entstehung und das Schicksal des Universums zu verstehen, weiter. Vor dem Hintergrund einer historischen Theorie des wissenschaftlichen Fortschritts wird Einsteins bis heute nicht abgeschlossene Revolution als das Ergebnis einer langfristigen Entwicklung des Wissens verständlich. Anhand der spannenden Geschichte von Einsteins Entdeckungen wird nachvollziehbar, warum große Denker wie Einstein weiter gesehen haben als ihre Vorgänger. Sie standen nicht nur auf den Schultern von Riesen, also den wissenschaftlichen Leistungen einzelner großer Vorgänger wie Newton, sondern auch auf den Schultern von "Zwergen", dem wissenschaftlichen Wissen, dem technischen Wissen, und d...

  18. Vidensledelse og den sociale dimension i deling af viden

    DEFF Research Database (Denmark)

    Lauring, Jakob

    2004-01-01

    imidlertid et alternativt syn på viden som i højere grad inddrager den sociale dimension ved vidensdeling - den socialkonstruktivistiske opfattelse. I denne artikel vil jeg beskæftige mig med den socialkonstruktivistiske opfattelse af viden og beskrive, hvorledes denne synsvinkel kan rette fokus mod nogle...... meget væsentlige problemstillinger ved organisatorisk adfærd, som man ofte kommer til at ignorere, hvis man i for høj grad baserer ledelsen på en funktionalistisk opfattelse af viden. Delingen af viden er en aktuel udfordring for anvendelse af viden i forretningssammenhæng. Det er hovedsageligt det, som...... gør vidensbegrebet interessant i forhold til ledelse af virksomheder. - Fokus på de sociale barrierer for deling af viden Jeg vil i det kommende illustrere, hvilke betydninger den sociale dimension i deling af viden kan have for videnledelse. Det vil jeg gøre gennem beskrivelser af to forskellige...

  19. Molecular pathogenesis and mechanisms of thyroid cancer

    Science.gov (United States)

    Xing, Mingzhao

    2013-01-01

    Thyroid cancer is a common endocrine malignancy. There has been exciting progress in understanding its molecular pathogenesis in recent years, as best exemplified by the elucidation of the fundamental role of several major signalling pathways and related molecular derangements. Central to these mechanisms are the genetic and epigenetic alterations in these pathways, such as mutation, gene copy-number gain and aberrant gene methylation. Many of these molecular alterations represent novel diagnostic and prognostic molecular markers and therapeutic targets for thyroid cancer, which provide unprecedented opportunities for further research and clinical development of novel treatment strategies for this cancer. PMID:23429735

  20. Uddrag af Ph.d.-afhandlingen Den groteske modernisme

    DEFF Research Database (Denmark)

    Lübker, Henrik

    2011-01-01

    Om forholdet mellem "det groteske" og "den groteske modernisme" eksemplificeret i en læsning af E.A. Poes "The Fall of the House of Usher" og flere af Francis Bacons malerier.......Om forholdet mellem "det groteske" og "den groteske modernisme" eksemplificeret i en læsning af E.A. Poes "The Fall of the House of Usher" og flere af Francis Bacons malerier....

  1. Den danske stat og det naturlige fædreland

    DEFF Research Database (Denmark)

    Glenthøj, Rasmus

    2007-01-01

    forsøgte på engang at være loyale over for både det statsborgerlige fædreland, der inkluderede hele den danske stat, og deres naturlige fædreland Norge, som de følte sig forbundet til gennem deres nationalitet og opvækst. Danskerne opererede med den samme dualistiske fædrelandsopfattelse, hvor de både...

  2. Nonsurgical management of two unusual cases of dens in dente

    Directory of Open Access Journals (Sweden)

    Gupta R

    2005-01-01

    Full Text Available The management of two unusual cases of dens invaginatus in a maxillary and a mandibular lateral incisor with a periradicular lesion are reported. The patient presented with pain and localized swelling. Despite the complex anatomy and diagnosis of dens invaginatus, nonsurgical root canal treatment was performed successfully. Furthermore essential clinical considerations and treatment options are suggested. Early diagnosis and management are important to avoid complications.

  3. Dens invaginatus: review, relevance, and report of 3 cases.

    Science.gov (United States)

    Khan, Suleman Abbas; Khan, Saima Yunus; Bains, Vivek K; Bains, Rhythm; Loomba, Kapil

    2012-01-01

    Dens invaginatus is a rare developmental morphoanatomical variation resulting from the infolding of the dental papilla before biological mineralization that allows the invagination of inner dental epithelium. Permanent maxillary lateral incisors are most commonly affected, and the condition is frequently bilateral, but it may also prevail in permanent maxillary central incisors. The purpose of this paper was to provide an overview of the etiopathogenesis, frequency of occurrence, and clinical and radiographic features and to discuss 3 dens invaginatus cases.

  4. CIOs mangler fundamentale egenskaber for at lede den digitale transformation

    DEFF Research Database (Denmark)

    Bjørn-Andersen, Niels

    2016-01-01

    CIOs er dårligt rustet til at gå i spidsen for digital disruption og innovation, advarer den internationale topforsker Joe Peppard med afsæt i analyse af mere end 200 CIO-s personligheder......CIOs er dårligt rustet til at gå i spidsen for digital disruption og innovation, advarer den internationale topforsker Joe Peppard med afsæt i analyse af mere end 200 CIO-s personligheder...

  5. Triple dens invaginatus in a single tooth: Rarest of rare case report.

    Science.gov (United States)

    Chhina, Amandeep; Chhina, Kamalpreet; Kaushal, Nitin; Walia, Ira

    2017-01-01

    Dens invaginatus is a rare malformation affecting the teeth. The teeth that are most commonly affected are the permanent maxillary lateral incisors. The mandibular posterior teeth are rarely affected by dens invaginatus. In most of the cases, a single dens invaginatus is seen affecting the tooth. Cases of double dens invaginatus affecting a single tooth are rare, and those of triple dens invaginatus in a single tooth are even rarer. Here, we present a case of a 14-year-old where three dens invaginatus were seen in the mandibular second premolar. This is the fourth case of three dens invaginatus in a single tooth as only three have been reported previously.

  6. Genes contributing to prion pathogenesis

    DEFF Research Database (Denmark)

    Tamgüney, Gültekin; Giles, Kurt; Glidden, David V

    2008-01-01

    incubation times, indicating that the conversion reaction may be influenced by other gene products. To identify genes that contribute to prion pathogenesis, we analysed incubation times of prions in mice in which the gene product was inactivated, knocked out or overexpressed. We tested 20 candidate genes...... show that many genes previously implicated in prion replication have no discernible effect on the pathogenesis of prion disease. While most genes tested did not significantly affect survival times, ablation of the amyloid beta (A4) precursor protein (App) or interleukin-1 receptor, type I (Il1r1...

  7. Femmes et représentation au Pakistan : voix d'en bas et voix d'en ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Femmes et représentation au Pakistan : voix d'en bas et voix d'en haut. L'initiative Gouvernance démocratique, droits des femmes et égalité entre les sexes du CRDI appuie un ensemble de recherches comparatives visant à déterminer si les institutions de démocratie et de gouvernance tiennent compte des droits des ...

  8. Pathogenesis of giant colonic diverticula

    International Nuclear Information System (INIS)

    Muhletaler, C.A.; Berger, J.L.; Robinette, C.L. Jr.

    1981-01-01

    The clinical, radiographic, and pathologic findings of 3 patients with giant colonic diverticula are presented. Although several theories have been proposed for the formation of these diverticula, they have not been fully documented. One of our cases illustrates the evolution of this disorder following typical colonic diverticulitis. The pathogenesis and differential diagnosis of this unusual entity are discussed. (orig.)

  9. Molecular pathogenesis of intrahepatic cholangiocarcinoma

    DEFF Research Database (Denmark)

    Andersen, Jesper Bøje

    2014-01-01

    Cholangiocarcinoma (CCA) is an orphan cancer of the hepatobiliary tract, the incidence of which has increased in the past decade. The molecular pathogenesis of this treatment-refractory disease is poorly understood. Desmoplasia is a key causal feature of CCA; however, a majority of tumors develop...

  10. Ubiquitination in melanoma pathogenesis and treatment.

    Science.gov (United States)

    Ma, Jinyuan; Guo, Weinan; Li, Chunying

    2017-06-01

    Melanoma is one of the most aggressive skin cancers with fiercely increasing incidence and mortality. Since the progressive understanding of the mutational landscape and immunologic pathogenic factors in melanoma, the targeted therapy and immunotherapy have been recently established and gained unprecedented improvements for melanoma treatment. However, the prognosis of melanoma patients remains unoptimistic mainly due to the resistance and nonresponse to current available drugs. Ubiquitination is a posttranslational modification which plays crucial roles in diverse cellular biological activities and participates in the pathogenesis of various cancers, including melanoma. Through the regulation of multiple tumor promoters and suppressors, ubiquitination is emerging as the key contributor and therefore a potential therapeutic target for melanoma. Herein, we summarize the current understanding of ubiquitination in melanoma, from mechanistic insights to clinical progress, and discuss the prospect of ubiquitination modification in melanoma treatment. © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

  11. Management of dens invaginatus type III with large periradicular lesion.

    Science.gov (United States)

    Falcao, Luciana de Souza; de Freitas, Priscila Sousa; Marreiro, Raquel de Oliveira; Garrido, Angela Delfina Bittencourt

    2012-01-01

    This study describes a clinical case of type III dens invaginatus with an extensive periradicular lesion treated successfully. Dens invaginatus is a maldevelopment of the dental germ which occurs as a result of the invagination of the enamel organ. These cases may present difficulties with respect to its diagnosis and treatment because of canal morphology. The success of endodontic therapy requires a knowledge of dental anatomy and its anomalies. A 17-year-old female patient is reported presenting right maxillary lateral incisor (tooth no. 7) classified as type III dens invaginatus with necrotic pulp and presence of an extensive radiolucid lesion. Endodontic treatment was recommended for tooth. However, intracanal exudate was present, suggesting a resistant infection. Enucleation of the lesion was performed as a complementary approach. The root canal obturation was carried out by the gutta-percha thermoplastification technique with root canal sealer, followed by restoration of the tooth. Healing of the lesion with hard tissue formation was confirmed at follow-up. A combination of endodontic and surgical treatments were fundamental to the maintenance of the tooth. The treatment was considered successful. Root canal therapy of dens invaginatus should be based on a thorough clinical and radiographic evaluation. The knowledge of classification and anatomical variations of teeth with dens invaginatus are of great importance for correct treatment.

  12. American black bear denning behavior: Observations and applications using remote photography

    Science.gov (United States)

    Bridges, A.S.; Fox, J.A.; Olfenbuttel, C.; Vaughan, M.B.

    2004-01-01

    Researchers examining American black bear (Ursus americanus) denning behavior have relied primarily on den-site visitation and radiotelemetry to gather data. Repeated den-site visits are time-intensive and may disturb denning bears, possibly causing den abandonment, whereas radiotelemetry is sufficient only to provide gross data on den emergence. We used remote cameras to examine black bear denning behavior in the Allegheny Mountains of western Virginia during March-May 2003. We deployed cameras at 10 den sites and used 137 pictures of black bears. Adult female black bears exhibited greater extra-den activity than we expected prior to final den emergence, which occurred between April 12 and May 6, 2003. Our technique provided more accurate den-emergence estimation than previously published methodologies. Additionally, we observed seldom-documented behaviors associated with den exits and estimated cub age at den emergence. Remote cameras can provide unique insights into denning ecology, and we describe their potential application to reproductive, survival, and behavioral research.

  13. Fra 1800-tals familie til den moderne familie

    DEFF Research Database (Denmark)

    Christoffersen, Mogens

    2004-01-01

    Sociologer som Talcot Parsons og William J. Goode mente, at konsekvensen af industrialiseringen også ville blive en indskrænkning af intimiteten og kontakten mellem kernefamilien og den øvrige slægt. En lang række af de funktioner, der blev varetaget af familie og slægt, blev overtaget af det...... omgivende samfund (fx børnenes uddannelse og alderdomsforsørgelsen). Nutidens samfund med en høj geografisk og social mobilitet skulle ydermere bidrage til en isolation af kernefamilien i forhold til den øvrige slægt. Andre sociologer fremhæver den individuelle frihed, som denne udvikling medfører for de...

  14. INTEGRAL entdeckt den Gamma-Himmel: Gamma-Astronomie

    Science.gov (United States)

    Schönfelder, Volker

    2004-11-01

    Das Gamma-Weltraumteleskop INTEGRAL der Europäischen Weltraumbehörde, ESA, hat in den ersten 15 Monaten seiner Mission eine Fülle interessanter, neuer Ergebnisse geliefert. Hauptinstrumente an Bord sind das hoch auflösende Spektrometer SPI und das Spektrometer IBIS. Hinzu kommt je ein Monitor für den Röntgen- und optischen Bereich. Die wichtigsten neuen Erkenntnisse stammen vor allem aus dem Bereich harter kompakter Röntgenquellen und aus dem Bereich der Gammalinien-Spektroskopie. Mit INTEGRAL wurde es erstmals möglich, den diffusen galaktischen Hintergrund zum Teil mit Einzelquellen identifizieren zu können. Ferner ließ sich in der Umgebung des galaktischen Zentrums die 511-keV-Linie von annihilierenden Positronen und Elektronen nachweisen. Schließlich trägt INTEGRAL auch entscheidend zum Studium der geheimnisvollen Gamma Ray Bursts bei.

  15. A rare case of dens invaginatus in a mandibular canine.

    Science.gov (United States)

    George, Roy; Moule, Alexander J; Walsh, Laurence J

    2010-08-01

    Dens invaginatus (dens in dente) is a common dental anomaly with a reported prevalence of between 0.04% and 10%. It typically affects permanent maxillary lateral incisors, central incisors and premolars. These developmental lesions are less common in mandibular teeth and are extremely rare in canines and molars. This report describes a rare case of dens invaginatus (Oehlers type II) in a permanent mandibular canine. The tooth was mature with a closed apex and showed apical pathosis. The tooth was treated endodontically using a non-surgical technique with hand endodontic files, and then followed up after a period of 8 months. A follow-up radiograph showed some healing of the lesion.

  16. Etiology and pathogenesis of the Marfan syndrome: current understanding.

    Science.gov (United States)

    Pyeritz, Reed E

    2017-11-01

    Much has changed regarding Marfan syndrome (MFS) over the past few decades. Once described solely as a heritable disorder of connective tissue, MFS is now one of a number of conditions recognized to be a disorder of abnormal signalling in the TGF-β pathway. The cardinal features of MFS, once encompassed by the ocular, skeletal and cardiovascular systems, are now known to encompass many more organ systems, especially as people with MFS grow older. They are growing older by several decades compared to the 1970's because of profound improvements in diagnosis and management of the cardiovascular features, especially dilatation of the aortic root. This dilatation can be detected first in infancy and followed up by echocardiography. Progressive enlargement increases the risk of type A dissection and aortic regurgitation, the major causes of early mortality, in untreated patients today. Medical therapy with β-adrenergic blockade, first shown to be effective in the 1980's, can retard this dilatation. In the past decade, angiotensin receptor blockade, which reduces aberrant signalling through one of the TGF-β pathways, also can be effective. However, when dilatation of the root becomes such that the risk of dissection increases to an unacceptable degree, surgical therapy becomes necessary. In the mid-1970's, the composite graft, introduced by Hugh Bentall, markedly reduced mortality. In the past decade, a valve-spring aortic root replacement, advanced by Tirone David, has become widely adopted. Mid-term results are quite encouraging. Other cardiovascular involvement, such as mitral valve prolapse, type B dissection, and dilatation and dissection of aortic branches, also require close monitoring. Currently, life-expectancy in people with MFS who are diagnosed early and treated prophylactically is approaching that of the general population.

  17. Understanding Splenomegaly in Myelofibrosis: Association with Molecular Pathogenesis

    Directory of Open Access Journals (Sweden)

    Moo-Kon Song

    2018-03-01

    Full Text Available Myelofibrosis (MF is a clinical manifestation of chronic BCR-ABL1-negative chronic myeloproliferative neoplasms. Splenomegaly is one of the major clinical manifestations of MF and is directly linked to splenic extramedullary hematopoiesis (EMH. EMH is associated with abnormal trafficking patterns of clonal hematopoietic cells due to the dysregulated bone marrow (BM microenvironment leading to progressive splenomegaly. Several recent data have emphasized the role of several cytokines for splenic EMH. Alteration of CXCL12/CXCR4 pathway could also lead to splenic EMH by migrated clonal hematopoietic cells from BM to the spleen. Moreover, low Gata1 expression was found to be significantly associated with the EMH. Several gene mutations were found to be associated with significant splenomegaly in MF. In recent data, JAK2 V617F homozygous mutation was associated with a larger spleen size. In other data, CALR mutations in MF were signigicantly associated with longer larger splenomegaly-free survivals than others. In addition, MF patients with ≥1 mutations in AZXL1, EZH1 or IDH1/2 had significantly low spleen reduction response in ruxolitinib treatment. Developments of JAK inhibitors, such as ruxolitinib, pacritinib, momelotinib, and febratinib enabled the effective management in MF patients. Especially, significant spleen reduction responses of the drugs were demonstrated in several randomized clinical studies, although those could not eradicate allele burdens of MF.

  18. Understanding Schizophrenia

    DEFF Research Database (Denmark)

    Henriksen, Mads Gram

    2012-01-01

    Indenfor den biologiske psykiatri opfattes skizofrene symptomer såsom bizarre vrangforestillinger og verbale hallucinationer som kausale udfald af genetisk nedarvede biologiske abnormiteter. Denne fremherskende monokausale opfattelse af skizofreni afspejler en udbredt ambition om at forankre psyk...

  19. Arkitektur og plan i den danske velfærdsby 1950-1990

    DEFF Research Database (Denmark)

    Pedersen, Poul Bæk

    2005-01-01

    Den danske arkitektur- og planhistorie fra 1950 til 1990 'genskrives' i denne bog ud fra et sammenhængende arkitektur- og byperspektiv. Afsættet er en typologisk forståelse af den danske by, der rummer både den historiske by og de nyere bydele.......Den danske arkitektur- og planhistorie fra 1950 til 1990 'genskrives' i denne bog ud fra et sammenhængende arkitektur- og byperspektiv. Afsættet er en typologisk forståelse af den danske by, der rummer både den historiske by og de nyere bydele....

  20. Dauerquadrat-Untersuchungen in den Allgäuer Alpen

    OpenAIRE

    Runge, Fritz

    1988-01-01

    ln den Jahren 1977-1983 wurden in den Alpen südlich von Oberstdorf/Allgäu 5 Dauerquadrate eingerichtet. Sie lagen in einer Schwemmlingsflur, in einem Alpenrosen-Gebüsch, in einer Alpendost-Hochstaudenflur bzw. einem Geißbart-Schluchtwald, in einem Grünerlen-Busch und einem Silberblatt-Scluchtwald. Die Änderungen der Vegetation dieser in 840 bis 1755 m Höhe gelegenen Dauerboebachtungsflächen sind in 5 Tabellen dokumentiert. Between 1977 and 1983 five permanent plots were established at 840 ...

  1. Die Umweltschäden und Entsorgungsprobleme des russischen Nuklearkomplexes

    OpenAIRE

    Kronfeld-Goharani, Ulrike

    2002-01-01

    "Als Nachfolgestaat der ehemaligen Sowjetunion mit ihrer gigantischen Nuklearindustrie zählt Russland heute zu den Ländern, in denen sich große Mengen Nuklearmüll angereichert haben und einzelne Regionen des Landes von radioaktiven Kontaminationen besonders stark betroffen sind. Ungeachtet dessen änderte im Juni 2001 das russische Parlament das Umweltgesetz, um verbrauchten Nuklearbrennstoff aus dem Ausland in großen Mengen zu importieren. Während Befürworter der Gesetzesänderungen den Import...

  2. Kurz zum Klima: Zu viel Salz verdirbt den Boden

    OpenAIRE

    Zimmer, Markus; Lippelt, Jana; Frank, Jonas

    2012-01-01

    Der zunehmende Einsatz von Anlagen zur Bewässerung sowie mangelnde Erfahrungswerte und Unkenntnis über den richtigen Einsatz der künstlichen Bewässerung haben in den letzten Jahrzehnten zu einer massiven Zunahme der Versalzung des Bodens geführt. Durch diese Bodenversalzung werden weite Flächen für die Landwirtschaft unbrauchbar. Sie sind nur durch hohen Aufwand und Kosten wieder renaturierbar. Der Beitrag in der Reihe »Kurz zum Klima« gibt einen Überblick über die Versalzung in Anbaugebiet...

  3. Facial Cellulitis Arising from Dens Evaginatus: A Case Report

    Directory of Open Access Journals (Sweden)

    Chun-Ming Chen

    2005-07-01

    Full Text Available Dens evaginatus is a developmental anomaly that produces a tubercle on the occlusal surface of a tooth. It is found most frequently in the mandibular premolars. The occlusal tubercle easily causes occlusal interferences. Attrition or fracture of the tubercle can lead to pulpitis, pulp necrosis, periapical pathosis, and periapical infection. This case report illustrates the treatment of facial cellulitis arising from dens evaginatus with open apex. Calcium hydroxide was used for the apexification procedure. One year after canal obturation, radiography revealed no apical pathosis and the apical seal was evident.

  4. Financial Inclusion: Reformen in den Bereichen Verbraucherschutz und finanzielle Allgemeinbildung

    OpenAIRE

    Christa Hainz

    2011-01-01

    Nicht zuletzt der Mangel an wirksamer Offenlegung von Informationen und irreführende Werbung auf Seiten der Anbieter sowie mangelndes Verständnis bezüglich Finanzprodukten auf Seiten der Konsumenten trugen dazu bei, dass der Markt für Subprime-Hypotheken in den USA zusammenbrach. Eine Verbesserung dieses institutionellen Umfelds sollte deshalb dazu dienen, derart negative Entwicklungen in der Zukunft zu verhindern. Der Beitrag gibt einen Überblick, welche Industrieländer Reformen in den Berei...

  5. APEXIFICATION OF A TOOTH WITH DENS INVAGINATUS (A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Epita Sarah Pane

    2015-08-01

    Full Text Available Dens invaginatus is a developmental malformation of teeth. A successful treatment of a maxillary lateral with dens invaginatus extending to mid root area, incomplete apical closure and large apical radiolucency will be presented. Sixteen months apexification with calcium hydroxide dressing was effective in resolving the problem after ultrasonic debridement, sodium hypochlorite irrigation. A 6-month recall radiograph is presented showing successful healing of the periapical lesion. Conventional endodontic treatment with calcium hydroxide apexification showed a favourable healing and will enhance the prognosis of the tooth.

  6. GULag-konference i Landstingssalen, Christiansborg, den 25. september 2012

    DEFF Research Database (Denmark)

    Frederichsen, Kim; Fledelius, Karsten; Foverskov, Carl Erik

    2012-01-01

    Artikel med referater af indlæg på og samlet vurdering af konference afholdt på Christiansborg om GULag, de sovjetiske KZ-lejre i Stalin-tiden arrangeret af Den Danske Helsinki-Komité for menneskerettigheder, Dansk-Russisk Forening og gulag.dk......Artikel med referater af indlæg på og samlet vurdering af konference afholdt på Christiansborg om GULag, de sovjetiske KZ-lejre i Stalin-tiden arrangeret af Den Danske Helsinki-Komité for menneskerettigheder, Dansk-Russisk Forening og gulag.dk...

  7. Radicular Dens Invaginatus: Report of a Rare Case

    Science.gov (United States)

    Beena, V. T.; Sivakumar, R.; Heera, R.; Rajeev, R.; Choudhary, Kanaram; Panda, Swagatika

    2012-01-01

    Dens invaginatus is a developmental anomaly resulting from invagination of a portion of crown forming within the enamel organ during odontogenesis. The invagination ranges from a slight pitting (coronal type) to an anomaly occupying most of the crown and root (radicular type). Although a clinical examination may reveal a deep fissure or pit on the surface of an anterior tooth, radiographic examination is the most realistic way to diagnose the invagination. The objective of this case presentation is to report a rare case of radicular dens in dente, which is a rare dental anomaly. PMID:22900211

  8. Nonsurgical endodontic treatment of type II dens invaginatus

    Science.gov (United States)

    MA, Rajini; Kaiwar, Anjali; N, Meena; Kumari R, Anitha; Shetty, Ashish; DN, Naveen; N, Shubhashini

    2009-01-01

    The endodontic treatment of teeth with dens invaginatus, characterized by an infolding of enamel and dentin, extending deep into the pulp cavity near the root apex, may be complicated and challenging. The complexity of the internal anatomy may create challenges for the complete removal of diseased pulpal tissue and the subsequent sealing of the canal system. Because of the bizarre root canal anatomy and widely open apex, a combination of nonsurgical and surgical endodontic treatment or extraction is the most common choice of therapy. This article describes case reports of nonsurgical endodontic treatment of Type II dens invaginatus associated with periradicular lesion. PMID:20617071

  9. Radicular Dens Invaginatus: Report of a Rare Case

    Directory of Open Access Journals (Sweden)

    V. T. Beena

    2012-01-01

    Full Text Available Dens invaginatus is a developmental anomaly resulting from invagination of a portion of crown forming within the enamel organ during odontogenesis. The invagination ranges from a slight pitting (coronal type to an anomaly occupying most of the crown and root (radicular type. Although a clinical examination may reveal a deep fissure or pit on the surface of an anterior tooth, radiographic examination is the most realistic way to diagnose the invagination. The objective of this case presentation is to report a rare case of radicular dens in dente, which is a rare dental anomaly.

  10. The role of EPCR in the pathogenesis of severe malaria

    DEFF Research Database (Denmark)

    Mosnier, Laurent O; Lavstsen, Thomas

    2016-01-01

    malaria syndromes and that these PfEMP1 variants contain EPCR binding domains provides new opportunities to improve our understanding of the molecular mechanisms responsible for the pathogenesis of severe malaria. EPCR is known for its essential role in the protein C (PC) system and for its ability...... the new paradigm that EPCR plays a central role in the pathogenesis of severe malaria. Thus, targeting of the PfEMP1-EPCR interaction and restoring the functionality of the PC system may provide new strategies for the development of novel adjuvant therapies for severe malaria....

  11. Recent advances in dengue pathogenesis and clinical management.

    Science.gov (United States)

    Simmons, Cameron P; McPherson, Kirsty; Van Vinh Chau, Nguyen; Hoai Tam, D T; Young, Paul; Mackenzie, Jason; Wills, Bridget

    2015-12-10

    This review describes and commentates on recent advances in the understanding of dengue pathogenesis and immunity, plus clinical research on vaccines and therapeutics. We expand specifically on the role of the dermis in dengue virus infection, the contribution of cellular and humoral immune responses to pathogenesis and immunity, NS1 and mechanisms of virus immune evasion. Additionally we review a series of therapeutic intervention trials for dengue, as well as recent clinical research aimed at improving clinical diagnosis, risk prediction and disease classification. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  12. Animal models of papillomavirus pathogenesis.

    Science.gov (United States)

    Campo, M Saveria

    2002-11-01

    Tumorigenesis due to papillomavirus (PV) infection was first demonstrated in rabbits and cattle early last century. Despite the evidence obtained in animals, the role of viruses in human cancer was dismissed as irrelevant. It took a paradigm shift in the late 1970s for some viruses to be recognised as 'tumour viruses' in humans, and in 1995, more than 60 years after Rous's first demonstration of CRPV oncogenicity, WHO officially declared that 'HPV-16 and HPV-18 are carcinogenic to humans'. Experimental studies with animal PVs have been a determining factor in this decision. Animal PVs have been studied both as agents of disease in animals and as models of human PV infection. In addition to the study of PV infection in whole animals, in vitro studies with animal PV proteins have contributed greatly to the understanding of the mechanisms of cell transformation. Animal PVs cause distressing diseases in both farm and companion animals, such as teat papillomatosis in cattle, equine sarcoids and canine oral papillomatosis and there is an urgent need to understand the pathogenesis of these problematic infections. Persistent and florid teat papillomatosis in cows can lead to mastitis, prevent the suckling of calves and make milking impossible; heavily affected animals are culled and so occasionally are whole herds. Equine sarcoids are often recurrent and untreatable and lead to loss of valuable animals. Canine oral papillomatosis can be very extensive and persistent and lead to great distress. Thus the continuing research in the biology of animal PVs is amply justified. BPVs and CRPV have been for many years the model systems with which to study the biology of HPV. Induction of papillomas and their neoplastic progression has been experimentally demonstrated and reproduced in cattle and rabbits, and virus-cofactor interactions have been elucidated in these systems. With the advancements in molecular and cell culture techniques, the direct study of HPV has become less

  13. Management of a Type III dens invaginatus using a combination surgical and non-surgical endodontic therapy: a case report.

    Science.gov (United States)

    Hegde, Mithra N; Shetty, Aditya; Sagar, Rekha

    2009-09-01

    The aim of this report is to present a case of Type III dens invaginatus in a maxillary lateral incisor with a periapical lesion and its successful treatment using a combination of surgical and non-surgical therapy. The morphology of the root canal system is unique for individual teeth. A precise understanding of the morphology is very important for a successful root canal treatment. Dens invaginatus is a rare dental anomaly that can give rise to many complex anatomical forms. The complete removal of the diseased pulp tissue can be a challenge for clinicians due to the complexity of internal canal anatomy and may require either non-surgical endodontic therapy alone or that therapy may have to be combined with surgical endodontics to achieve an adequate sealing of the root canal system. A 22-year-old male presented for evaluation of a recurrent painless sinus tract in the attached gingiva adjacent to the maxillary right lateral incisor. The tooth responded negatively to vitality tests while the right central incisor responded normally. Clinically an anatomical malformation in the crown was detected in the form of an abnormal bulbous contour of the tooth in the palatal region above the cingulum. Radiograph evaluation confirmed the presence of dens invaginatus and a periapical radiolucent lesion. The patient received combined non-surgical and surgical endodontic therapy to achieve a favorable outcome. Complications presented by Type III dens invaginatus and acute periapical abscess necessitated the use of combined non-surgical and surgical endodontic therapy to attain a favorable seal of the root canal. The prognosis at a six-month post-treatment evaluation appeared to be good. Dens invaginatus requires an early diagnosis and treatment. It may result in radicular and periapical pathosis requiring a combined non-surgical and surgical endodontic approach to treatment.

  14. Cellular and molecular mechanisms of chikungunya pathogenesis.

    Science.gov (United States)

    Lum, Fok-Moon; Ng, Lisa F P

    2015-08-01

    Chikungunya virus (CHIKV) is an arthropod-borne virus that causes chikungunya fever, a disease characterized by the onset of fever and rashes, with arthralgia as its hallmark symptom. CHIKV has re-emerged over the past decade, causing numerous outbreaks around the world. Since late 2013, CHIKV has reached the shores of the Americas, causing more than a million cases of infection. Despite concentrated efforts to understand the pathogenesis of the disease, further outbreaks remain a threat. This review highlights important findings regarding CHIKV-associated immunopathogenesis and offers important insights into future directions. This article forms part of a symposium in Antiviral Research on "Chikungunya discovers the New World." Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Skønhed og rædsel i den nye Pharma Science Building

    DEFF Research Database (Denmark)

    Reeh, Henrik

    2016-01-01

    Reportage fra et fælles besøg i den nyligt indviede PharmaScience Building, Københavns Universitet, juni 2016. Teksten om mødet mellem journalist og forsker på den ene side og bygningen og dens brugere på den anden side. Journalist Christoffer Zieler henviser til Henrik Reehs separat offentliggjo......Reportage fra et fælles besøg i den nyligt indviede PharmaScience Building, Københavns Universitet, juni 2016. Teksten om mødet mellem journalist og forsker på den ene side og bygningen og dens brugere på den anden side. Journalist Christoffer Zieler henviser til Henrik Reehs separat...

  16. Hemmelig ransagning og brevstandsning i den digitale virkelighed

    DEFF Research Database (Denmark)

    Lentz, Lene Wacher

    2016-01-01

    Artiklen tager udgangspunkt i sager om databedrageri, hvor betalingskort misbruges til køb på internettet. Politiets adgang til private chatfora på nettet analyseres i forhold til de straffeprocessuelle tvangsindgreb hemmelig ransagning, aflytning og dataaflæsning. Desuden behandler artiklen den ...

  17. Tegnets tid. Fortid, historie og historicitet efter den sproglige vending

    DEFF Research Database (Denmark)

    Simonsen, Dorthe Gert

    I Tegnets tid undersøges nyeste videnskabsteoretiske strømninger og deres betydning for historisk forskning. Forfatteren anvender den franske filosof Jacques Derridas teorier til at nyformulere og genåbne hævdvundne problemstillinger i historien: fortidsbegrebet, fagets kildekritiske tradition og...

  18. Rum, rammer og biblioteker i den virtuelle verden

    DEFF Research Database (Denmark)

    Heilesen, Simon

    2009-01-01

    Med udgangspunkt i en kort introduktion til hvordan rum og rammer gestaltes i den virtuelle 3‐D verden Second Life, undersøger denne artikel, på hvilke måder rum og rammesætning anvendes og opleves i en faglig sammenhæng. Som eksempel anvendes det danske biblioteksprojekt i Second Life, Info Island...

  19. Cloud computing og den strafferetlige beskyttelse af data

    DEFF Research Database (Denmark)

    Mathiasen, Peter Dueholm

    2013-01-01

    Cloud computing er blevet en populær metode for bl.a. at opbevare data. Muligheden for eksempelvis at placere forretningskritiske data på teknisk udstyr, som ejes af den udbyder, der driver cloud computing tjenesten, gør det aktuelt at forholde sig til, om straffeloven i sådanne tilfælde yder et...

  20. An Interview with DOROTHY E. DENNING, Oral History 424

    OpenAIRE

    Yost, Jeffrey R.

    2013-01-01

    Computer Security History Project Computer security pioneer Dorothy Denning discusses her career including her Lattice Model for Computer Security, research on database security, intrusion detection, and other areas, such as her influential textbooks. The interview also addresses computer security research infrastructure and collaborators at various institutions where she worked including Purdue University, SRI International, Digital Equipment Corporation, Georgetown University, and Naval ...

  1. Activity rhythms and distribution of natal dens for red foxes

    Science.gov (United States)

    Wenyang, Zhou; Wanhong, Wei; Biggins, Dean E.

    1995-01-01

    The red fox, Vulpes vulpes, was investigated with snow tracking, radiotracking and directive observation at the Haibei Research Station of Alpine Meadow Ecosystem, Academia Sinica, from March to September 1994. The objectives of this study were to determine the distribution and use of natal dens, activity rhythms, and home range sizes for the foxes.

  2. Når religionen indtager den politiske debat

    DEFF Research Database (Denmark)

    Andersen, Rune

    2009-01-01

    Tidligere var politiske spørgsmål forankret i en sekulær argumentation, men med hændelser som "9/11"og "Muhammedtegningerne" har religionen entreret den offentlige debat. Dette gælder ikke mindst argumentationen om Tyrkiets optagelse i EU, der har sit mest markante udtryk blandt Dansk Folkepartis...

  3. Den za Dnjom võib omanikku vahetada / Dannar Leitmaa

    Index Scriptorium Estoniae

    Leitmaa, Dannar, 1982-

    2008-01-01

    Eesti populaarsemat venekeelset nädalalehte Den za Dnjom välja andva OÜ Merger Meedia juhi Andres Tiisleri sõnul käivad läbirääkimised ajalehe müügiks. Krediidiinfo andmetel on ettevõtte maksuvõlg 1,225 miljonit krooni

  4. God smag og bordskik er den bedste slankekur

    DEFF Research Database (Denmark)

    Andersen, Boris

    2011-01-01

    Rockwool Fondens Forskningsenhed har for nylig offentliggjort rapporten ’Helbred, trivsel og overvægt blandt danskerne’, der viser, at antallet af svært overvægtige i USA og Storbritannien er over dobbelt så stort som i Danmark. Den franske madsociolog Claude Fischler beskæftiger sig med sammenhæ...

  5. Hyekyung Cho: Chinas langer Marsch in den Kapitalismus

    DEFF Research Database (Denmark)

    Czeskleba-Dupont, Rolf

    2006-01-01

    Chos afhandling fra Berlin refereres i hovedtræk. Tre modsætninger tages op i den: 1) mellem 'transitionen' ind i kapitalismen og herredømmet af et kommunistisk parti, hvor det bl.a.viser sig at particentralen fremmer liberaliseringen i kampen mod statsvirksomhederne; 2) mellem integrationen i ve...

  6. Kapitalismens ånd og den kreative etik

    DEFF Research Database (Denmark)

    Stephensen, Jan Løhmann

    hyldes nu det kreative arbejde, de kreative erhverv og den kreative økonomi som eksemplariske scener for udfoldelsen af denne eftertragtede evne, som hævdes at udgøre rygraden i nutidens og ikke mindst fremtidens kulturelle og økonomiske logik. Med afsæt i bl.a. Max Weber samt Luc Boltanski & Eve...

  7. Den naturlige samtale i fremmedsproglig læring

    DEFF Research Database (Denmark)

    Ambjørn, Lone; Troensegaard, Agnete

    2005-01-01

    Formålet med denne artikel er at plædere, ikke alene for bevarelsen af den nye arbejds- og eksamensform, som oparbejdelse af fremmedsproglig samtalefærdighed indebærer, men også for styrkelse af tiltag, der på lignende vis kunne fremme sprogelevernes læringsproces og medansvaret herfor....

  8. Om den sociale og symbolske funktion af uddannelsesevalueringer

    DEFF Research Database (Denmark)

    Nørholm, Morten

    Afhandlingens teoretiske udgangspunkt er hos Émile Durkheim, Pierre Bourdieu, Ulf P. Lund­gren, Staf Callewaert, det konkrete er en række evalueringer af uddannelser til (semi)professioner inden for sundhedssektoren.                I afhandlingen konstrueres den sociale og symbolske funktion af u...

  9. Aktivistisk med forbehold? Danmark, EU og den amerikanske verdensorden

    DEFF Research Database (Denmark)

    Wivel, Anders

    2017-01-01

    reflekterer de globale og europæiske incitamenter. Dansk europapolitik formuleres af danske beslutningstagere som en nødvendighedens politik, men dette udelukker ikke en aktivisme, der ofte fremstår som dristig i sin udfordring af den dominerende tysk-fransk forståelse af EU’s betydning og fremtid....

  10. Historien om den kostbare læringstid

    DEFF Research Database (Denmark)

    Henriksen, Carsten

    2015-01-01

    Danmarkshistorien har aldrig rigtig haft plads til de mindste børn. Men nu fortæller forskere fra DPU for første gang historien om, hvordan nutidens daginstitutioner og den moderne pædagogprofession er blevet til. Overraskende viser det sig, at politikere og pædagogiske tænkere gennem de sidste 2...

  11. Einfluss verschiedener Beladeeinrichtungen auf den Ertrag eines Kombisystems

    DEFF Research Database (Denmark)

    Jordan, Ulrike; Vejen, Klaus

    2002-01-01

    thermosyphonischer Volumenstrom lassen sich daher durch die Konstruktion der Beladeeinheit beeinflussen. Kombispeicher mit verschiedenen Beladeeinrichtungen (intern, extern, thermosyphonisch durchströmt) wurden u.a. bereits von den Solar-Forschungs- und Testinstituten ITW Stutt-gart (z.B. Drück98) und SERC Borlänge...

  12. Den centraleuropæiske fortælling

    DEFF Research Database (Denmark)

    Østergaard, Uffe

    2014-01-01

    Om EU's udvidelse mod øst- og centraleuropa. Om hvordan Hitler og Stalins masseudrydelser har betydet mere for den europæiske identitete og sammenhængskraft end kristendommen, og hvordan antisemitisme er blevet en form for kode og fælles sprog for mennesker, der drømmer om en nationalt eller...

  13. Pulp revascularization of immature dens invaginatus with periapical periodontitis.

    Science.gov (United States)

    Yang, Jie; Zhao, Yuming; Qin, Man; Ge, Lihong

    2013-02-01

    Dens invaginatus is a rare developmental malformation of a tooth caused by the invagination of the tooth crown before biological mineralization occurs. The complex anatomy of these teeth makes nonsurgical endodontic treatment difficult and more so when there is presence of periapical periodontitis with open apex. The endodontic treatment of dens invaginatus is a challenge, especially in the case of periapical periodontitis with open apex. Pulp revascularization is a conservative endodontic treatment that has been introduced in recent years. Presented here is a variant approach for the treatment of immature dens invaginatus type II with periapical periodontitis, which combines filling of the invagination and pulp revascularization. After accessing the pulp chamber, the main canal and the invagination were explored. The root was thoroughly disinfected by irrigating and medication, invagination was filled, and the main canal was revascularized. Then the coronal sealing was made by glass ionomer cement and composite resin. Radiograph taken regularly and computed tomography scan were used to investigate the healing of the periapical lesion and development of the root. In the subsequent follow-up, the periapical lesion was completely eliminated, the open apex was closed, and the wall of the root was thickened. For type II immature dens invaginatus with large periapical lesion, conservative endodontic treatment should be considered before periapical surgery. With sufficient infection control, pulp revascularization can be an effective alternative method. Copyright © 2013 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  14. Endodontic management of dens invaginatus Type IIIb: Case series.

    Science.gov (United States)

    Martins, Jorge N R; da Costa, Rui Pereira; Anderson, Craig; Quaresma, Sérgio André; Corte-Real, Luís S M; Monroe, Adam D

    2016-01-01

    Dens invaginatus may be seen as a developmental malformation. It is characterized by an invagination of the enamel and dentin, creating a lumen inside the affected tooth, which may extend as deep as the apical foramen. Oehlers Type IIIb is considered the most challenging clinical conditions. The purpose of this study is to discuss the nonsurgical endodontic management of vital and necrotic dens invaginatus Type IIIb cases. Due to the complex anatomical consideration of dens invaginatus Type IIIb, endodontic treatment is extremely technique sensitive. A conservative approach was used in a vital case to treat the invaginated lumen only, to preserve the vitality of the pulp, and a more invasive approach was used in a necrotic case to debride the lumen and necrotic pulp for proper disinfection of the root canal system. Although different, all the approaches were successful. The clinical signs and symptoms were resolved. The vital case remains vital after 19 months, and the recall radiographs were able to show satisfactory periapical healing both in vital and necrotic cases. Due to the highly complex anatomy of dens invaginatus Type IIIb, the decision of preserving the pulp vitality may not be related only to pulpal diagnosis but also to the technical requirements of the treatment. Although very technically sensitive, it may be possible to treat the invaginated lumen exclusively, while preserving the vitality of the pulp. Necrotic cases may require a more aggressive approach to achieve a favorable prognosis.

  15. Den Europeiska unionen i en globaliserande värld

    DEFF Research Database (Denmark)

    Manners, Ian James

    2013-01-01

    faktor för att förstå regionala ansträngningar att samordna olika ekonomiska, sociala, miljömässiga och politiska förändringar. Regionalt integrationsarbete och globaliseringen av livsstilar har tillsammans blivit del av den centrala dynamiken i förbindelserna mellan EU och världen. Som Julia Kristeva...

  16. Fractures of the dens complicating ankylosing spondylitis with atlantooccipital fusion.

    Science.gov (United States)

    Miller, F H; Rogers, L F

    1991-05-01

    Patients with ankylosing spondylitis are prone to fractures. Fractures tend to occur in the lower cervical spine disc space. We describe 2 patients with odontoid fractures. Both patients had atlantooccipital fusion which may have increased their susceptibility for dens fractures. One patient had Crohn's disease.

  17. Corporate Social Responsibility i forsyningskæden

    DEFF Research Database (Denmark)

    Liempd, Dennis van

    2007-01-01

    Styring og kontrol af etiske risici i forsyningskæden som en del af virksomhedens samfundsansvar (corporate social re­sponsibility; CSR) er blevet mere og mere vigtig nu til dags. Der er stor national og international fokus på CSR-området, ikke mindst fordi globaliseringen har gjort, at flere...

  18. Biology and pathogenesis of Acanthamoeba

    Directory of Open Access Journals (Sweden)

    Siddiqui Ruqaiyyah

    2012-01-01

    Full Text Available Abstract Acanthamoeba is a free-living protist pathogen, capable of causing a blinding keratitis and fatal granulomatous encephalitis. The factors that contribute to Acanthamoeba infections include parasite biology, genetic diversity, environmental spread and host susceptibility, and are highlighted together with potential therapeutic and preventative measures. The use of Acanthamoeba in the study of cellular differentiation mechanisms, motility and phagocytosis, bacterial pathogenesis and evolutionary processes makes it an attractive model organism. There is a significant emphasis on Acanthamoeba as a Trojan horse of other microbes including viral, bacterial, protists and yeast pathogens.

  19. Biology and pathogenesis of Acanthamoeba

    Science.gov (United States)

    2012-01-01

    Acanthamoeba is a free-living protist pathogen, capable of causing a blinding keratitis and fatal granulomatous encephalitis. The factors that contribute to Acanthamoeba infections include parasite biology, genetic diversity, environmental spread and host susceptibility, and are highlighted together with potential therapeutic and preventative measures. The use of Acanthamoeba in the study of cellular differentiation mechanisms, motility and phagocytosis, bacterial pathogenesis and evolutionary processes makes it an attractive model organism. There is a significant emphasis on Acanthamoeba as a Trojan horse of other microbes including viral, bacterial, protists and yeast pathogens. PMID:22229971

  20. Polen vor der Middle-Income-Trap? Entwicklungsplan bis 2030 soll den Aufholprozess beschleunigen

    OpenAIRE

    Holtemöller, Oliver; Kämpfe, Martina

    2017-01-01

    Polen hat seinen Abstand gegenüber den entwickelten Marktwirtschaften Westeuropas seit dem Beginn der 1990er Jahre bis heute gemessen am Pro-Kopf-Einkommen stark verringert. Galt das Land in den ersten zwei Jahrzehnten unter den mittelosteuropäischen Ländern als Vorreiter beim Wirtschaftswachstum, so hat sich das Aufholtempo in den letzten Jahren verlangsamt. Die polnische Regierung reagierte darauf mit einem strategischen Entwicklungsplan ('Morawiecki'-Plan), der Maßnahmen und Ziele bis 2030...

  1. KGB : de russiske sikkerhedstjenester fra Ivan den Grusomme til Vladimir Putin

    DEFF Research Database (Denmark)

    Kulavig, Erik

    Om den russiske sikkerhedstjeneste eller det hemmelige politis historie fra starten under Ivan den Grusomme i 1600-tallet, gennem tsarernes Rusland og bolsjevikkernes Sovjetunionenen til Putins periode. Med afstikkere til aktiviteterne uden for Ruslands grænser, herunder i Danmark......Om den russiske sikkerhedstjeneste eller det hemmelige politis historie fra starten under Ivan den Grusomme i 1600-tallet, gennem tsarernes Rusland og bolsjevikkernes Sovjetunionenen til Putins periode. Med afstikkere til aktiviteterne uden for Ruslands grænser, herunder i Danmark...

  2. Asymptomatic ''crowned dens'' calcification in CT images for the craniovertebral junction

    International Nuclear Information System (INIS)

    Kubota, Gen; Mori, Masataka; Fukushima, Tatsuro

    2007-01-01

    Calcification around the odontoid process suggests 'crowned dens' syndrome, when accompanied with acute occipital headache or neck pain and with inflammatory signs. We retrospectively searched for calcification around the odontoid process in routine CT images of 282 patients emcompassing the craniovertebral junction, and found 13 (4.6%) had 'crowned dens' calcifications with neither characteristic symptoms nor signs suggestive for crowned dens' syndrome. Females of older ages frequently showed asymptomatic crowned dens' calcifications. (author)

  3. Multiple dens invaginatus, mulberry molar and conical teeth : case report and genetic considerations

    OpenAIRE

    Sedano, Heddie O.; Ocampo Acosta, Fabian; Naranjo Corona, Rosa I.; Torres Arellano, María Eleuteria

    2009-01-01

    Dens in dente, also known as dens invaginatus and dilated compound odontoma, is a malformation that can occur on primary, permanent, or supernumerary teeth that is characterized by a deep invagination of the surface of a crown or root covered with enamel. This abnormality in tooth morphology generally affect the maxillary lateral incisors but several cases of multiple dens invaginatus have been reported in the literature. A 15 year-old female patient is reported here presenting five dens ...

  4. Management of dens invaginatus type II with periapical lesion: case report.

    Science.gov (United States)

    Uzun, Ismail; Keskin, Cangul; Guler, Bugra; Ozdemir, Ozgur

    2015-01-01

    Dens invaginatus is a developmental anomaly resulting from epithelial invagination of the tooth crown before calcification. Endodontic treatment of teeth affected by dens invaginatusmay be difficult and complex due to aberrant anatomy. Combined orthograde and surgical approaches for successful treatment of dens invaginatus are effective. This report describes the successful treatmentand results atthe 12-month follow-up of a maxillary lateral incisor showing dens invaginatus type II, a large periapical lesion and an open apex by using combined surgical and endodontic treatment.

  5. Non-Surgical Root Canal Treatment of Dens Invaginatus 3 in a Maxillary Lateral Incisor

    OpenAIRE

    Moradi, Saeed; Donyavi, Zakyeh; Esmaealzade, Mohammad

    2008-01-01

    The aim of this case report was to describe the clinical management of an unusual dens invaginatus type 3. A case of dens invaginatus in a maxillary lateral incisor with a periapical lesion is reported. The patient presented with pain and localized swelling. Despite the complex anatomy and diagnosis of dens invaginatus, non-surgical root canal treatment was performed successfully. Key Learning Points: - Dens invaginatus may be presented in different forms, and the etiology of this phenomenon ...

  6. Den sociale praksis omkring arbejdsmiljø

    DEFF Research Database (Denmark)

    Kamp, Annette

    model, and to understand the ambiguous outcomes of the application of new principles at enterprise level.The thesis take departure in theoretical contributions, which regard political processes as important for the understanding of organizations. The aim is to develop and consolidate this approach....... Emphasis is laid on the analysis of the social processes, that lead to a specific shaping of the managment system, in a few longitudinal case studies. The management systems, which have strong rationalistic and bureaucratic bearings, are conceived as political change programmes, where specific conceptions...... of organization, man, problems and solutions are embedded. The study illustrates how these change programmes are transformed through processes of negotiation, and how the existing local conceptions of work environment play an important part, so that in reality the 'new' contains elements of old thinking and old...

  7. Filosofisk terapi som træning til døden

    DEFF Research Database (Denmark)

    Dræby, Anders

    Den eksistentielfænomenologiske terapi deler den opfattelse med stoicismen, at filosofiens hovedopgave er at hjælpe mennesket med at finde vej i en problematisk verden. Oplægget udforsker desuden et overlap, som består i den indsigt, at terapeutisk udfrielse fra menneskelig lidelse til livsduelig...

  8. Dwellers in dens on sandy bottoms: Ecological and behavioural traits of Octopus vulgaris

    Directory of Open Access Journals (Sweden)

    Ángel Guerra

    2014-09-01

    Full Text Available Four visual censuses targeting Octopus vulgaris living in dens on sandy bottoms were carried out from June to October 2013 in the National Park of the Atlantic Galician Islands (NW Spain. Censuses were undertaken by scuba diving between 5 and 21 m depth in daytime. The total area swept was 13.75 ha. There were no significant differences between octopus presence in dens during open and closed fishing seasons. Depth had a significant negative relationship with occupancy. The average number of dens per 1000 m2 was 3.84±0.84 in June and 3.89 in October. The area per den was 260 m2. Den number estimations varied between 1586 and 2057. The largest number of dens (76.5% was found between 5 and 10 m depth. Den distribution was clumped. No significant differences were found between octopus size classes (small, medium and large and den diameter. Associate dens were observed. There were no significant differences in den diameter and shell types found around the middens. Many dens could be “permanent”. Drilling bivalve shell behaviour is discussed. The surveyed area had around 1100 individuals, mainly small specimens. No significant differences were found between octopus size and depth. Substrate, den type and food abundance and availability (especially razors Ensis arcuatus seem to be the main factors influencing dens and octopus density and distribution. Den availability does not appear to be a limiting factor in this case. Temperature, den availability, predators and fishing pressure influencing density and distribution are discussed. Rodas inlet may be a preferential habitat for O. vulgaris individuals ranging from 200 to 2000 g, but especially small specimens ( ≤ 1000 g.

  9. Strategisk ledelse i den offentlige sektor

    DEFF Research Database (Denmark)

    Hansen, Morten Balle

    2009-01-01

    of tightly coupled relations between top management decisions and organizational behaviour, (c) a neo-rational trust in decision-makers' ability to calculate the consequences of their decisions, (d) a perception of organizations as rigid systems whose change can only be accomplished by heroic top managers......, and (e) an understanding of organizations as unitary actors and conflict as primarily taking place in the environment. Based on research in organizational behaviour and Public administration these notions are criticized and an alternative perspective envisioning a more humble role for strategic top...... management is suggested. Often (a) managers are better portrayed as puppets, (b) managerial decisions better understood as rational rituals, (c) unintended consequences of decisions the rule rather than the exception, (d) organizational change better understood as relatively independent of leaders and (e...

  10. Non-surgical root canal treatment of dens invaginatus 3 in a maxillary lateral incisor.

    Science.gov (United States)

    Moradi, Saeed; Donyavi, Zakyeh; Esmaealzade, Mohammad

    2008-01-01

    The aim of this case report was to describe the clinical management of an unusual dens invaginatus type 3. A case of dens invaginatus in a maxillary lateral incisor with a periapical lesion is reported. The patient presented with pain and localized swelling. Despite the complex anatomy and diagnosis of dens invaginatus, non-surgical root canal treatment was performed successfully. - Dens invaginatus may be presented in different forms, and the etiology of this phenomenon is not fully understood. - Due to abnormal anatomical configuration, dens invaginatus presents technical difficulties in its clinical management. - Non-surgical root canal treatment can be performed successfully.

  11. Ion channelopathies and migraine pathogenesis.

    Science.gov (United States)

    Albury, Cassie L; Stuart, Shani; Haupt, Larisa M; Griffiths, Lyn R

    2017-08-01

    Migraine is a common neurological disorder that affects approximately 12-20% of the general adult population. Migraine pathogenesis is complex and not wholly understood. Molecular genetic investigations, imaging and biochemical studies, have unveiled a number of interconnected neurological pathways which seem to have a cause and effect component integral to its cause. Much weight of migraine attack initiation can be placed on the initial trigger and the pathways involved in its neuronal counter reaction. Ion channels play a large role in the generation, portrayal and mitigation of the brains response to external triggers. Several genetic studies have identified and implicated a number of ion channelopathy genes which may contribute to this generalised process. This review will focus on the genetics of migraine with particular emphasis placed on the potentially important role genes HEPH (responsible for iron transport and homeostasis) and KCNK18 (important for the transport and homeostasis of potassium) play in migraine cause.

  12. Rosacea: Epidemiology, pathogenesis, and treatment

    Science.gov (United States)

    Rainer, Barbara M.; Kang, Sewon; Chien, Anna L.

    2017-01-01

    ABSTRACT Rosacea is a chronic relapsing inflammatory skin disease with a high prevalence among adults of Northern European heritage with fair skin. Symptoms present in various combinations and severity, often fluctuating between periods of exacerbation and remission. Based on morphological characteristics, rosacea is generally classified into four major subtypes: erythematotelangiectatic, papulopustular, phymatous, and ocular. Diverse environmental and endogenous factors have been shown to stimulate an augmented innate immune response and neurovascular dysregulation; however, rosacea's exact pathogenesis is still unclear. An evidence-based approach is essential in delineating differences between the many available treatments. Because of the diverse presentations of rosacea, approaches to treatment must be individualized based on the disease severity, quality-of-life implications, comorbidities, trigger factors, and the patient's commitment to therapy. PMID:29484096

  13. The Pathogenesis of Nontraumatic Osteonecrosis

    Directory of Open Access Journals (Sweden)

    Jesse Seamon

    2012-01-01

    Full Text Available Nontraumatic osteonecrosis continues to be a challenging problem causing debilitating major joint diseases. The etiology is multifactorial, but steroid- and alcohol-induced osteonecrosis contribute to more than two thirds of all cases with genetic risk factors playing an important role in many other cases, especially when they contribute to hypercoagulable states. While the exact mechanisms remain elusive, many new insights have emerged from research in the last decade that have given us a clearer picture of the pathogenesis of nontraumatic osteonecrosis of the femoral head. Progression to end stage osteonecrosis of the femoral head appears to be related to four main factors: interactions involving the differentiation pathway of osteoprogenitor cells that promote adipogenesis, decreased angiogenesis, direct suppression of osteogenic gene expression and proliferation of bone marrow stem cells, and genetic anomalies or other diseases that promote hypercoagulable states.

  14. Etiology and Pathogenesis of Psoriasis.

    Science.gov (United States)

    Boehncke, Wolf-Henning

    2015-11-01

    Psoriasis is a common, chronic inflammatory skin disease most often appearing in the form of well-demarcated, scaly plaques. These lesions highlight the fundamental processes underlying its pathogenesis, namely, inflammation and epidermal hyperproliferation. Both phenomena are considered consequences of an intimate interplay between the innate and the adaptive immune system. This concept is supported by results of genetic studies, pointing toward the signaling pathways of nuclear factor-κB, interferon-γ, and interleukin (IL)-23 as well as antigen presentation as central axes of the psoriatic inflammation. Efficacy of biologics targeting tumor necrosis factor-α, IL-23, or IL-17 provides further evidence in favor of this model. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Selection of den sites by black bears in the southern Appalachians

    Science.gov (United States)

    Reynolds-Hogland, M. J.; Mitchell, M.S.; Powell, R.A.; Brown, D.C.

    2007-01-01

    We evaluated selection of den sites by American black bears (Ursus americanus) in the Pisgah Bear Sanctuary, western North Carolina, by comparing characteristics of dens at 53 den sites with availability of habitat characteristics in annual home ranges of bears and in the study area. We also tested whether den-site selection differed by sex, age, and reproductive status of bears. In addition, we evaluated whether the den component of an existing habitat model for black bears predicted where bears would select den sites. We found bears selected den sites far from gravel roads, on steep slopes, and at high elevations relative to what was available in both annual home ranges and in the study area. Den-site selection did not differ by sex or age, but it differed by reproductive status. Adult females with cubs preferred to den in areas that were relatively far from gravel roads, but adult females without cubs did not. The habitat model overestimated the value of areas near gravel roads, underestimated the value of moderately steep areas, and did not include elevation as a predictor variable. Our results highlight the importance of evaluating den selection in terms of both use and availability of den characteristics. ?? 2007 American Society of Mammalogists.

  16. Raccoon (Procyon lotor) diurnal den use within an intensively managed forest in central West Virginia

    Science.gov (United States)

    Owen, Sheldon F.; Berl, Jacob L.; Edwards, John W.; Ford, W. Mark; Wood, Petra Bohall

    2015-01-01

    Intensive forest management may influence the availability of suitable den sites for large den-seeking species, such as Procyon lotor (Raccoon). As part of a Raccoon ecology study on an industrial forest in the Allegheny Mountains of central West Virginia, we radio-tracked 32 Raccoons to 175 diurnal den sites to determine relative use of dens that included cavity trees, rock dens, log piles, slash piles, and exposed limbs. Patterns of den use significantly differed between sexes and among seasons. Overall, we recorded 58 cavity dens in 12 tree species with 7 maternal dens found in 5 tree species. Raccoons selected larger-diameter den trees than available cavity trees and non-cavity trees. Because the abundance of suitable tree cavities is known to influence Raccoon densities and recruitment at fine spatial scales and female Raccoons in this study used tree cavities as maternal den sites, the continued harvest of large-diameter trees (i.e., those capable of developing den cavities) without replacement may impact Raccoon recruitment within intensively managed forests throughout the central Appalachians.

  17. New Insights into the Pathogenesis of Pancreatitis

    Science.gov (United States)

    Sah, Raghuwansh P.; Dawra, Rajinder K.; Saluja, Ashok K.

    2014-01-01

    Purpose of review In this article, we review important advances in our understanding of the mechanisms of pancreatitis. Recent Findings The relative contribution of intra-pancreatic trypsinogen activation and NFκB activation, the two major early independent cellular events in the etiology of pancreatitis, have been investigated using novel genetic models. Trypsinogen activation has traditionally held the spotlight for many decades as it is believed to be the central pathogenic event of pancreatitis However, recent experimental evidence points to the role of trypsin activation in early acinar cell damage but not in the inflammatory response of acute pancreatitis through NFκB activation. Further, chronic pancreatitis in the caerulein model develops independently of typsinogen activation. Sustained activation of the NFκB pathway, but not persistent intra-acinar expression of active trypsin, was shown to result in chronic pancreatitis. Calcineurin-NFAT signaling was shown to mediate downstream effects of pathologic rise in intracellular calcium. IL-6 was identified as a key cytokine mediating pancreatitis-associated lung injury. Summary Recent advances challenge the long-believed trypsin-centered understanding of pancreatitis. It is becoming increasingly clear that activation of intense inflammatory signaling mechanisms in acinar cells is crucial to the pathogenesis of pancreatitis, which may explain the strong systemic inflammatory response in pancreatitis. PMID:23892538

  18. Zika virus genome biology and molecular pathogenesis.

    Science.gov (United States)

    Wang, Anyou; Thurmond, Stephanie; Islas, Leonel; Hui, Kingyung; Hai, Rong

    2017-03-22

    Zika virus (ZIKV) is an emerging RNA virus in the widespread Flavivirus genus. Recently, ZIKV has rapidly spread around the world and has been implicated in human disease, including neurological disorders, triggering public and scientific attention. Understanding how ZIKV causes disease is the highest priority, yet little is known about this virus. Here we examine the currently published data from ZIKV studies to provide the latest understanding of ZIKV genome biology and molecular pathogenesis. The ZIKV genome evolved rapidly from the Flavivirus genus and diverged from the members of this genus, even within the dengue virus cluster to which ZIKV belongs. Genome variations and divergences also exist among ZIKV strains/isolates. These genome divergences might account for the uniqueness of Zika disease. ZIKV infection activates not only the antiviral immune response but also the pro-inflammatory responses associated with disease symptoms. Strikingly, ZIKV activates protein complexes that are functionally associated with disease process, such as glial cell activation and proliferation (for example, Toll-like receptors), apoptosis and cell death, and inflammation. The activation of these complexes may critically contribute to Zika disease. The novel insights into ZIKV genome divergence and disease mechanisms summarized in this review will help accelerate the development of anti-ZIKV strategies.

  19. Triple dens invaginatus in a single tooth: Rarest of rare case report

    Directory of Open Access Journals (Sweden)

    Amandeep Chhina

    2017-01-01

    Full Text Available Dens invaginatus is a rare malformation affecting the teeth. The teeth that are most commonly affected are the permanent maxillary lateral incisors. The mandibular posterior teeth are rarely affected by dens invaginatus. In most of the cases, a single dens invaginatus is seen affecting the tooth. Cases of double dens invaginatus affecting a single tooth are rare, and those of triple dens invaginatus in a single tooth are even rarer. Here, we present a case of a 14-year-old where three dens invaginatus were seen in the mandibular second premolar. This is the fourth case of three dens invaginatus in a single tooth as only three have been reported previously.

  20. Den sociala frågans återkomst

    DEFF Research Database (Denmark)

    Petersson, Kenneth; Olsson, Ulf; Krejsler, John B.

    2014-01-01

    Inom samtidens berättelse om Europeisk utbildningspolitik betraktas livslangt lärande och den sociala dimensionen som centrala begrepp för att göra det möjligt att förverkliga den vision, EUROPE 2020 om ett framtida Europa med "smart, hållbar och inkluderande tillväxt", som antogs i 2010 (COM, 2010......, s.1). I denna berättelse betraktas det livslånga lärande som en förutsättning för såväl samhällets som individens lyckosamma utveckling samt för att skapa ett gott samhälle, demokratisk förståelse och ett aktiv medborgerligt deltagande (London Kommuniké 2007)....

  1. Können Statine den Knochenstoffwechsel positiv beeinflussen?

    Directory of Open Access Journals (Sweden)

    Vock L

    2005-01-01

    Full Text Available Statine, potente Inhibitoren der HMG-CoA-Reduktase, werden erfolgreich zur Senkung der Cholesterinblutspiegel eingesetzt. In den letzten Jahren sind jedoch zahlreiche andere Wirkungen der Statine aufgedeckt worden, die möglicherweise für den Knochenstoffwechsel von Bedeutung sind: In vitro konnten faszinierende knochenanabole Wirkungen der Statine bewiesen werden. Welche molekularen Mechanismen für diese Beobachtungen genau verantwortlich sind, ist nach wie vor unklar. Auch konnten in anderen In-vitro-Studien, Tiermodellen und klinischen Studien diese eindrucksvollen Resultate nicht immer bestätigt werden. Das vorliegende Bild der Statine im Knochenstoffwechsel ist uneinheitlich. Viele Fragen bleiben offen. Es fehlen neben genaueren Erkenntnissen über die Eigenschaften der einzelnen Statine auch Resultate besser auf diese Fragestellung zugeschnittener Studien.

  2. Begær, krop og den anden

    DEFF Research Database (Denmark)

    Thøgersen, Ulla

    Med fænomenologisk udgangspunkt fremmes forståelse af begær som lidenskab. Indledes med redegørelse og diskussion af analyser af begær hos Merleau-Ponty, Sartre og Lévinas. Og fortsætter med at skrive om begærets dynamik med fokus på kroppen og den anden......Med fænomenologisk udgangspunkt fremmes forståelse af begær som lidenskab. Indledes med redegørelse og diskussion af analyser af begær hos Merleau-Ponty, Sartre og Lévinas. Og fortsætter med at skrive om begærets dynamik med fokus på kroppen og den anden...

  3. Corporate Social Responsibility i forsyningskæden

    DEFF Research Database (Denmark)

    Liempd, Dennis van

    2007-01-01

    Styring og kontrol af etiske risici i forsyningskæden som en del af virksomhedens samfundsansvar (corporate social re­sponsibility; CSR) er blevet mere og mere vigtig nu til dags. Der er stor national og international fokus på CSR-området, ikke mindst fordi globaliseringen har gjort, at flere...... for hvilke virksomheder, det kan være interessant. Der præsenteres nogle teoretiske tilgange og modeller, som findes i den akademiske litteratur. Endvi­dere diskuteres nogle drivkræfter og forskellige motivatio­ner, som gør, at virksomheder beskæftiger sig med CSR i praksis. Artiklen viser også hvordan man...

  4. Leadership Pipeline på rejse i den offentlige sektor

    DEFF Research Database (Denmark)

    Nielsen, Jeppe; Dahl, Kristian Aagaard

    2015-01-01

    udbredelse af Leadership Pipeline modellen. Forskningslitteraturen om Leadership Pipeline er imidlertid beskeden. Med teoretisk ammunition fra ”idé på rejse” perspektivet og et multi-level case studie i den danske offentlige sektor belyser artiklen udbredelse og implementering af Leadership Pipeline. Ved...... at anvende skiftende teoretiske begreber og henholdsvis zoome-ind (organisationsniveau) og zoome-ud (feltniveau) viser artiklen, hvordan en række gensidigt forbundne teoretiserings- og translationsaktiviteter sikrede Leadership Pipeline legitimitet og fremskyndede dens udbredelse samtidig med, at forskellige...... praksisvarianter af Leadership Pipeline udkrystalliserede sig i offentlige organisationer med hver deres kendetegn og problemdefinitioner. Med afsæt i denne empiri argumenterer vi for, at implementering af Leadership Pipeline udspillede sig i overlappende teoretiserings- og translationsaktiviteter, der forstærkede...

  5. Den monofone lyrik: puisque som eksempel

    DEFF Research Database (Denmark)

    Ægidius, Adam

     Findes der indikationer på, at lyrikken er monofon, sådan som Bakhtine hævdede? Konnektoren puisque bruges i romaner ofte til at skabe dækket direkte tale, mens den – som jeg her viser det –  i lyrik kun iscenesætter digterens egen stemme....... Findes der indikationer på, at lyrikken er monofon, sådan som Bakhtine hævdede? Konnektoren puisque bruges i romaner ofte til at skabe dækket direkte tale, mens den – som jeg her viser det –  i lyrik kun iscenesætter digterens egen stemme....

  6. Erlebten Frauen den Holocaust anders als Männer?

    Directory of Open Access Journals (Sweden)

    Angela Schwarz

    2000-11-01

    Full Text Available Der vorliegende Sammelband basiert auf Vorträgen einer Konferenz aus dem Jahr 1995, auf der nach dem spezifischen Erleben des Holocaust durch Frauen gefragt wurde. In der Regel waren es Zeugnisse von Überlebenden, die die Grundlage für die Analyse von Verhalten und Reaktionen von Frauen bildeten. Diskutiert wurde aber nicht nur über die einzelnen Erfahrungsbereiche jüdischer Frauen in West- und Osteuropa in Zwischenkriegs- und Kriegszeit, sondern ebenso über die Anwendbarkeit der „Gender-Frage“ auf den Holocaust generell. Entstanden ist so ein interessanter Überblick über den aktuellen Stand der Diskussion, der die Grenzen und mehr noch die Chancen eines solchen Zugangs hervortreten läßt.

  7. Influenza A Virus-Host Protein Interactions Control Viral Pathogenesis.

    Science.gov (United States)

    Zhao, Mengmeng; Wang, Lingyan; Li, Shitao

    2017-08-01

    The influenza A virus (IAV), a member of the Orthomyxoviridae family, is a highly transmissible respiratory pathogen and represents a continued threat to global health with considerable economic and social impact. IAV is a zoonotic virus that comprises a plethora of strains with different pathogenic profiles. The different outcomes of viral pathogenesis are dependent on the engagement between the virus and the host cellular protein interaction network. The interactions may facilitate virus hijacking of host molecular machinery to fulfill the viral life cycle or trigger host immune defense to eliminate the virus. In recent years, much effort has been made to discover the virus-host protein interactions and understand the underlying mechanisms. In this paper, we review the recent advances in our understanding of IAV-host interactions and how these interactions contribute to host defense and viral pathogenesis.

  8. Comparative Pathogenesis and Systems Biology for Biodefense Virus Vaccine Development

    Directory of Open Access Journals (Sweden)

    Gavin C. Bowick

    2010-01-01

    Full Text Available Developing vaccines to biothreat agents presents a number of challenges for discovery, preclinical development, and licensure. The need for high containment to work with live agents limits the amount and types of research that can be done using complete pathogens, and small markets reduce potential returns for industry. However, a number of tools, from comparative pathogenesis of viral strains at the molecular level to novel computational approaches, are being used to understand the basis of viral attenuation and characterize protective immune responses. As the amount of basic molecular knowledge grows, we will be able to take advantage of these tools not only to rationally attenuate virus strains for candidate vaccines, but also to assess immunogenicity and safety in silico. This review discusses how a basic understanding of pathogenesis, allied with systems biology and machine learning methods, can impact biodefense vaccinology.

  9. New discoveries in the pathogenesis and classification of vitiligo.

    Science.gov (United States)

    Rodrigues, Michelle; Ezzedine, Khaled; Hamzavi, Iltefat; Pandya, Amit G; Harris, John E

    2017-07-01

    Vitiligo is a common autoimmune disease that progressively destroys melanocytes in the skin, resulting in the appearance of patchy depigmentation. This disfiguring condition frequently affects the face and other visible areas of the body, which can be psychologically devastating. The onset of vitiligo often occurs in younger individuals and progresses for life, resulting in a heavy burden of disease and decreased quality of life. Presentation patterns of vitiligo vary, and recognition of these patterns provides both diagnostic and prognostic clues. Recent insights into disease pathogenesis offer a better understanding of the natural history of the disease, its associations, and potential for future treatments. The first article in this continuing medical education series outlines typical and atypical presentations of vitiligo, how they reflect disease activity, prognosis, and response to treatment. Finally, we discuss disease associations, risk factors, and our current understanding of disease pathogenesis. Copyright © 2016 American Academy of Dermatology, Inc. All rights reserved.

  10. Entscheidungsmodell für den wirtschaftlichen RFID-Einsatz

    OpenAIRE

    Griemert, Silke

    2010-01-01

    Bedingt durch den ständig zunehmenden Kostendruck wird es für Unternehmen immer wichtiger, Kostensenkungspotenziale systematisch zu identifizieren. Eine von vielen Unternehmen genutzte strategische Option ist die internationale Arbeitsteilung. Kostenvorteile entstehen hier vor allem durch weltweit differierende Arbeitsentgelte und unterschiedliche rechtliche Rahmenbedingungen. Gleichzeitig erhöht sich aber die logistische Komplexität und droht, die Vorteile dieser Strategie zu konterkarieren....

  11. Den fjerde vej: Trumps sejr skaber ny samfundsorden

    DEFF Research Database (Denmark)

    Rasmussen, Martin Møller Boje; Andersen, Torben K.; Kragh, Claus

    2016-01-01

    Bag Donald Trumps uempatiske retorik gemmer sig omridset af et politisk projekt, man kan kalde den fjerde vej. USA’s kommende præsident blander højre- og venstreorienterede mærkesager til et nyt nationalsocialt politisk koncept. Spørgsmålet er, om Trumps fjerde vej er et seriøst bud på en ny...

  12. Den Pædagogiske Refleksionsmodel som sammenhængskraft

    DEFF Research Database (Denmark)

    Voergaard Poulsen, Bettina; Lucht, Camill; Vibholm Persson, Stine

    Den Pædagogiske Refleksions Model (PRM) illustrerer de vidensdimensioner, der indgår i en kvalificeret klinisk beslutning. I projektet 'Sammenhæng på TVÆRS i fremtidens sygeplejeuddannelse (PÅ TVÆRS)" indgår PRM som pædagogisk greb. Der undersøges om PRM skaber sammenhæng for studerendes læring i...

  13. Nonsurgical endodontic treatment of type II dens invaginatus

    OpenAIRE

    MA, Rajini; Kaiwar, Anjali; N, Meena; Kumari R, Anitha; Shetty, Ashish; DN, Naveen; N, Shubhashini

    2009-01-01

    The endodontic treatment of teeth with dens invaginatus, characterized by an infolding of enamel and dentin, extending deep into the pulp cavity near the root apex, may be complicated and challenging. The complexity of the internal anatomy may create challenges for the complete removal of diseased pulpal tissue and the subsequent sealing of the canal system. Because of the bizarre root canal anatomy and widely open apex, a combination of nonsurgical and surgical endodontic treatment or extrac...

  14. Nonconventional Therapeutic Protocol for Type III Dens Invaginatus.

    Science.gov (United States)

    Kunert, Gustavo G; Kunert, Itaborai R; de Figueiredo, José Ap; Barletta, Fernando B; Estrela, Carlos

    2017-03-01

    This study discusses a nonconventional therapeutic protocol for type III dens invaginatus. This condition is a disorder of dental development, caused by the invagination of enamel into coronal and/or radicular dentin structure. This promotes several structural alterations within the dental organ, which offers challenges and difficulties to perform the endodontic treatment when needed. This article reports a clinical case where a conservative approach was adopted to preserve the invagi-nated tooth, and endodontic treatment was performed in the main necrotic canal. Following 21 years of observation, a complete root formation could be seen, with dental pulp preservation of the pulpotomized tooth. Considering the reported difficulties for the treatment of dens invaginatus, conservative measures, such as pulpotomy to preserve the remaining dental pulp may be an excellent alternative to allow less invasive procedures, thus avoiding endodontic surgery. This study discusses a nonconventional therapeutic protocol for type III dens invaginatus. A conservative approach adopted preserved the invaginated tooth, and root canal treatment was performed in the main necrotic canal. Following 21 years of observation, there was complete root formation, with dental pulp preservation of the pulpotomized tooth.

  15. The pathogenesis of tendinopathy: balancing the response to loading

    DEFF Research Database (Denmark)

    Magnusson, S Peter; Jørgensen, Henning Langberg; Kjaer, Michael

    2010-01-01

    , such as tendinopathy, which is characterized by pain during activity, localized tenderness upon palpation, swelling and impaired performance. Tendon histological changes include reduced numbers and rounding of fibroblasts, increased content of proteoglycans, glycosaminoglycans and water, hypervascularization......, thus implying that one or more 'weak links' are present in the structure. Understanding how tendon tissue adapts to mechanical loading will help to unravel the pathogenesis of tendinopathy....

  16. Therapeutic implications from the pathogenesis of Raynaud's phenomenon

    OpenAIRE

    Herrick, Ariane L

    2017-01-01

    INTRODUCTION: Raynaud's phenomenon (RP) can be either primary (idiopathic) or secondary to a number of different diseases/conditions, when vasopasm can be superimposed upon structural vascular abnormality or a hyperviscosity state and may then lead to severe ischaemia with tissue damage. Treatment must be tailored to the individual. Areas covered: This review discusses how increased understanding of the pathogenesis of RP has driven and is driving new approaches to therapy, and how we are now...

  17. Deciphering the pathogenesis of tendinopathy: a three-stages process

    Directory of Open Access Journals (Sweden)

    Fu Sai-Chuen

    2010-12-01

    Full Text Available Abstract Our understanding of the pathogenesis of "tendinopathy" is based on fragmented evidences like pieces of a jigsaw puzzle. We propose a "failed healing theory" to knit these fragments together, which can explain previous observations. We also propose that albeit "overuse injury" and other insidious "micro trauma" may well be primary triggers of the process, "tendinopathy" is not an "overuse injury" per se. The typical clinical, histological and biochemical presentation relates to a localized chronic pain condition which may lead to tendon rupture, the latter attributed to mechanical weakness. Characterization of pathological "tendinotic" tissues revealed coexistence of collagenolytic injuries and an active healing process, focal hypervascularity and tissue metaplasia. These observations suggest a failed healing process as response to a triggering injury. The pathogenesis of tendinopathy can be described as a three stage process: injury, failed healing and clinical presentation. It is likely that some of these "initial injuries" heal well and we speculate that predisposing intrinsic or extrinsic factors may be involved. The injury stage involves a progressive collagenolytic tendon injury. The failed healing stage mainly refers to prolonged activation and failed resolution of the normal healing process. Finally, the matrix disturbances, increased focal vascularity and abnormal cytokine profiles contribute to the clinical presentations of chronic tendon pain or rupture. With this integrative pathogenesis theory, we can relate the known manifestations of tendinopathy and point to the "missing links". This model may guide future research on tendinopathy, until we could ultimately decipher the complete pathogenesis process and provide better treatments.

  18. Molecular Pathogenesis of MALT Lymphoma

    Directory of Open Access Journals (Sweden)

    Katharina Troppan

    2015-01-01

    Full Text Available Approximately 8% of all non-Hodgkin lymphomas are extranodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT, also known as MALT lymphoma, which was first described in 1983 by Isaacson and Wright. MALT lymphomas arise at a wide range of different extranodal sites, with the highest frequency in the stomach, followed by lung, ocular adnexa, and thyroid, and with a low percentage in the small intestine. Interestingly, at least 3 different, apparently site-specific, chromosomal translocations and missense and frameshift mutations, all pathway-related genes affecting the NF-κB signal, have been implicated in the development and progression of MALT lymphoma. However, these genetic abnormalities alone are not sufficient for malignant transformation. There is now increasing evidence suggesting that the oncogenic product of translocation cooperates with immunological stimulation in oncogenesis, that is, the association with chronic bacterial infection or autoaggressive process. This review mainly discusses MALT lymphomas in terms of their genetic aberration and association with chronic infections and summarizes recent advances in their molecular pathogenesis.

  19. Achondroplasia: Development, pathogenesis, and therapy.

    Science.gov (United States)

    Ornitz, David M; Legeai-Mallet, Laurence

    2017-04-01

    Autosomal dominant mutations in fibroblast growth factor receptor 3 (FGFR3) cause achondroplasia (Ach), the most common form of dwarfism in humans, and related chondrodysplasia syndromes that include hypochondroplasia (Hch), severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN), and thanatophoric dysplasia (TD). FGFR3 is expressed in chondrocytes and mature osteoblasts where it functions to regulate bone growth. Analysis of the mutations in FGFR3 revealed increased signaling through a combination of mechanisms that include stabilization of the receptor, enhanced dimerization, and enhanced tyrosine kinase activity. Paradoxically, increased FGFR3 signaling profoundly suppresses proliferation and maturation of growth plate chondrocytes resulting in decreased growth plate size, reduced trabecular bone volume, and resulting decreased bone elongation. In this review, we discuss the molecular mechanisms that regulate growth plate chondrocytes, the pathogenesis of Ach, and therapeutic approaches that are being evaluated to improve endochondral bone growth in people with Ach and related conditions. Developmental Dynamics 246:291-309, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  20. Molecular Pathogenesis of MALT Lymphoma

    Science.gov (United States)

    Troppan, Katharina; Wenzl, Kerstin; Neumeister, Peter; Deutsch, Alexander

    2015-01-01

    Approximately 8% of all non-Hodgkin lymphomas are extranodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT), also known as MALT lymphoma, which was first described in 1983 by Isaacson and Wright. MALT lymphomas arise at a wide range of different extranodal sites, with the highest frequency in the stomach, followed by lung, ocular adnexa, and thyroid, and with a low percentage in the small intestine. Interestingly, at least 3 different, apparently site-specific, chromosomal translocations and missense and frameshift mutations, all pathway-related genes affecting the NF-κB signal, have been implicated in the development and progression of MALT lymphoma. However, these genetic abnormalities alone are not sufficient for malignant transformation. There is now increasing evidence suggesting that the oncogenic product of translocation cooperates with immunological stimulation in oncogenesis, that is, the association with chronic bacterial infection or autoaggressive process. This review mainly discusses MALT lymphomas in terms of their genetic aberration and association with chronic infections and summarizes recent advances in their molecular pathogenesis. PMID:25922601

  1. The Pathogenesis of Lupus Nephritis

    Science.gov (United States)

    Lech, Maciej

    2013-01-01

    Lupus nephritis is an immune complex GN that develops as a frequent complication of SLE. The pathogenesis of lupus nephritis involves a variety of pathogenic mechanisms. The extrarenal etiology of systemic lupus is based on multiple combinations of genetic variants that compromise those mechanisms normally assuring immune tolerance to nuclear autoantigens. This loss of tolerance becomes clinically detectable by the presence of antinuclear antibodies. In addition, nucleic acids released from netting or apoptotic neutrophils activate innate and adaptive immunity via viral nucleic acid-specific Toll-like receptors. Therefore, many clinical manifestations of systemic lupus resemble those of viral infection. In lupus, endogenous nuclear particles trigger IFN-α signaling just like viral particles during viral infection. As such, dendritic cells, T helper cells, B cells, and plasma cells all contribute to the aberrant polyclonal autoimmunity. The intrarenal etiology of lupus nephritis involves antibody binding to multiple intrarenal autoantigens rather than the deposition of circulating immune complexes. Tertiary lymphoid tissue formation and local antibody production add to intrarenal complement activation as renal immunopathology progresses. Here we provide an update on the pathogenic mechanisms that lead to lupus nephritis and provide the rationale for the latest and novel treatment strategies. PMID:23929771

  2. Pathogenesis of ovarian cancer: current perspectives | Chesang ...

    African Journals Online (AJOL)

    Objective: To present a review of current knowledge of the pathogenesis of ovarian cancer and its clinical implications. Data Source: Extensive literature search was conducted to identify relevant studies. Study Selection: Studies in the English language about or related to pathogenesis of ovarian cancer were selected.

  3. Preeclampsia: Updates in Pathogenesis, Definitions, and Guidelines.

    Science.gov (United States)

    Phipps, Elizabeth; Prasanna, Devika; Brima, Wunnie; Jim, Belinda

    2016-06-06

    Preeclampsia is becoming an increasingly common diagnosis in the developed world and remains a high cause of maternal and fetal morbidity and mortality in the developing world. Delay in childbearing in the developed world feeds into the risk factors associated with preeclampsia, which include older maternal age, obesity, and/or vascular diseases. Inadequate prenatal care partially explains the persistent high prevalence in the developing world. In this review, we begin by presenting the most recent concepts in the pathogenesis of preeclampsia. Upstream triggers of the well described angiogenic pathways, such as the heme oxygenase and hydrogen sulfide pathways, as well as the roles of autoantibodies, misfolded proteins, nitric oxide, and oxidative stress will be described. We also detail updated definitions, classification schema, and treatment targets of hypertensive disorders of pregnancy put forth by obstetric and hypertensive societies throughout the world. The shift has been made to view preeclampsia as a systemic disease with widespread endothelial damage and the potential to affect future cardiovascular diseases rather than a self-limited occurrence. At the very least, we now know that preeclampsia does not end with delivery of the placenta. We conclude by summarizing the latest strategies for prevention and treatment of preeclampsia. A better understanding of this entity will help in the care of at-risk women before delivery and for decades after. Copyright © 2016 by the American Society of Nephrology.

  4. Growth Factor Mediated Signaling in Pancreatic Pathogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Nandy, Debashis; Mukhopadhyay, Debabrata, E-mail: mukhopadhyay.debabrata@mayo.edu [Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, 200 First Street SW, Guggenheim 1321C, Rochester, MN 55905 (United States)

    2011-02-24

    Functionally, the pancreas consists of two types of tissues: exocrine and endocrine. Exocrine pancreatic disorders mainly involve acute and chronic pancreatitis. Acute pancreatitis typically is benign, while chronic pancreatitis is considered a risk factor for developing pancreatic cancer. Pancreatic carcinoma is the fourth leading cause of cancer related deaths worldwide. Most pancreatic cancers develop in the exocrine tissues. Endocrine pancreatic tumors are more uncommon, and typically are less aggressive than exocrine tumors. However, the endocrine pancreatic disorder, diabetes, is a dominant cause of morbidity and mortality. Importantly, different growth factors and their receptors play critical roles in pancreatic pathogenesis. Hence, an improved understanding of how various growth factors affect pancreatitis and pancreatic carcinoma is necessary to determine appropriate treatment. This chapter describes the role of different growth factors such as vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), platelet derived growth factor (PDGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), and transforming growth factor (TGF) in various pancreatic pathophysiologies. Finally, the crosstalk between different growth factor axes and their respective signaling mechanisms, which are involved in pancreatitis and pancreatic carcinoma, are also discussed.

  5. Pain and the pathogenesis of biceps tendinopathy

    Science.gov (United States)

    Raney, Elise B; Thankam, Finosh G; Dilisio, Matthew F; Agrawal, Devendra K

    2017-01-01

    Biceps tendinopathy is a relatively common ailment that typically presents as pain, tenderness, and weakness in the tendon of the long head of the biceps brachii. Though it is often associated with degenerative processes of the rotator cuff and the joint, this is not always the case, thus, the etiology remains considerably unknown. There has been recent interest in elucidating the pathogenesis of tendinopathy, since it can be an agent of chronic pain, and is difficult to manage. The purpose of this article is to critically evaluate relevant published research that reflects the current understanding of pain and how it relates to biceps tendinopathy. A review of the literature was conducted to create an organized picture of how pain arises and manifests itself, and how the mechanism behind biceps tendinopathy possibly results in pain. Chronic pain is thought to arise from neurogenic inflammation, central pain sensitization, excitatory nerve augmentation, inhibitory nerve loss, and/or dysregulation of supraspinal structures; thus, the connections of these theories to the ones regarding the generation of biceps tendinopathy, particularly the neural theory, are discussed. Pain mediators such as tachykinins, CGRP, and alarmins, in addition to nervous system ion channels, are highlighted as possible avenues for research in tendinopathy pain. Recognition of the nociceptive mechanisms and molecular of biceps tendinopathy might aid in the development of novel treatment strategies for managing anterior shoulder pain due to a symptomatic biceps tendon. PMID:28670360

  6. Achondroplasia: pathogenesis and implications for future treatment.

    Science.gov (United States)

    Laederich, Melanie B; Horton, William A

    2010-08-01

    Although the genetic defect underlying achondroplasia has been known for over a decade, no effective therapies to stimulate bone growth have emerged. Here we review the recent literature and summarize the molecular mechanisms underlying disease pathology and examine their potential as therapeutic targets. Currently used preclinical models are discussed in the context of recent advances with a special focus on C-type natriuretic peptide. Research on the mutation in Fibroblast Growth Factor Receptor 3 (FGFR3) that causes achondroplasia suggests that disease results from increased signal transduction from the mutant receptor. Thus, current therapeutic strategies have focused on reducing signals emanating from FGFR3. First-generation therapies directly targeting FGFR3, such as kinase inhibitors and neutralizing antibodies, designed for targeting FGFR3 in cancer, are still in the preclinical phase and have yet to translate into the management of achondroplasia. Counteracting signal transduction pathways downstream of FGFR3 holds promise with the discovery that administration of C-type natriuretic peptide to achondroplastic mice ameliorates their clinical phenotype. However, more research into long-term effectiveness and safety of this strategy is needed. Direct targeting of therapeutic agents to growth plate cartilage may enhance efficacy and minimize side effects of these and future therapies. Current research into the pathogenesis of achondroplasia has expanded our understanding of the mechanisms of FGFR3-induced disease and has increased the number of approaches that we may use to potentially correct it. Further research is needed to validate these approaches in preclinical models of achondroplasia.

  7. Apoptosis in cancer: from pathogenesis to treatment

    Directory of Open Access Journals (Sweden)

    Wong Rebecca SY

    2011-09-01

    Full Text Available Abstract Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. It is also one of the most studied topics among cell biologists. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. In some, the problem is due to too much apoptosis, such as in the case of degenerative diseases while in others, too little apoptosis is the culprit. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. The mechanism of apoptosis is complex and involves many pathways. Defects can occur at any point along these pathways, leading to malignant transformation of the affected cells, tumour metastasis and resistance to anticancer drugs. Despite being the cause of problem, apoptosis plays an important role in the treatment of cancer as it is a popular target of many treatment strategies. The abundance of literature suggests that targeting apoptosis in cancer is feasible. However, many troubling questions arise with the use of new drugs or treatment strategies that are designed to enhance apoptosis and critical tests must be passed before they can be used safely in human subjects.

  8. Preeclampsia: Updates in Pathogenesis, Definitions, and Guidelines

    Science.gov (United States)

    Phipps, Elizabeth; Prasanna, Devika; Brima, Wunnie

    2016-01-01

    Preeclampsia is becoming an increasingly common diagnosis in the developed world and remains a high cause of maternal and fetal morbidity and mortality in the developing world. Delay in childbearing in the developed world feeds into the risk factors associated with preeclampsia, which include older maternal age, obesity, and/or vascular diseases. Inadequate prenatal care partially explains the persistent high prevalence in the developing world. In this review, we begin by presenting the most recent concepts in the pathogenesis of preeclampsia. Upstream triggers of the well described angiogenic pathways, such as the heme oxygenase and hydrogen sulfide pathways, as well as the roles of autoantibodies, misfolded proteins, nitric oxide, and oxidative stress will be described. We also detail updated definitions, classification schema, and treatment targets of hypertensive disorders of pregnancy put forth by obstetric and hypertensive societies throughout the world. The shift has been made to view preeclampsia as a systemic disease with widespread endothelial damage and the potential to affect future cardiovascular diseases rather than a self-limited occurrence. At the very least, we now know that preeclampsia does not end with delivery of the placenta. We conclude by summarizing the latest strategies for prevention and treatment of preeclampsia. A better understanding of this entity will help in the care of at-risk women before delivery and for decades after. PMID:27094609

  9. Infantile hemangiomas: from pathogenesis to clinical features

    Directory of Open Access Journals (Sweden)

    Rosenblatt A

    2012-06-01

    Full Text Available Adena Rosenblatt,1 Erin F Mathes,2 Kristina W Rosbe31Department of Pediatrics, University of California, San Francisco, 2Division of Pediatric Dermatology, Departments of Dermatology and Pediatrics, University of California, San Francisco, 3Division of Pediatric Otolaryngology, Department of Otolaryngology – Head and Neck Surgery, University of California, San Francisco, CA, USAAbstract: Infantile hemangiomas (IH are benign vascular tumors consisting of a collection of immature cells, including progenitor stem cells and disorganized blood vessels. They are the most common benign tumors in childhood. Recently, there have been significant, exciting advancements in the understanding of the pathogenesis and treatment of infantile hemangiomas, which are discussed in this review. The decision to initiate treatment for IH is based on many factors, including size and location, functional compromise, psychosocial implications, and risks and benefits of the proposed therapy. For most families of children with hemangiomas, education about the natural history of IH and reassurance are often the only "treatment" required. A minority of patients with large, complex lesions or lesions that cause functional compromise require early intervention. These patients and families benefit from a multidisciplinary approach to care in vascular birthmark centers. Ongoing multi-institutional clinical trials will provide further important data on the efficacy and safety of hemangioma treatments.Keywords: progenitor stem cell, glucose transporter 1, PHACES, LUMBAR, infantile hemangioma

  10. The Pathogenesis of Ebola Virus Disease.

    Science.gov (United States)

    Baseler, Laura; Chertow, Daniel S; Johnson, Karl M; Feldmann, Heinz; Morens, David M

    2017-01-24

    For almost 50 years, ebolaviruses and related filoviruses have been repeatedly reemerging across the vast equatorial belt of the African continent to cause epidemics of highly fatal hemorrhagic fever. The 2013-2015 West African epidemic, by far the most geographically extensive, most fatal, and longest lasting epidemic in Ebola's history, presented an enormous international public health challenge, but it also provided insights into Ebola's pathogenesis and natural history, clinical expression, treatment, prevention, and control. Growing understanding of ebolavirus pathogenetic mechanisms and important new clinical observations of the disease course provide fresh clues about prevention and treatment approaches. Although viral cytopathology and immune-mediated cell damage in ebolavirus disease often result in severe compromise of multiple organs, tissue repair and organ function recovery can be expected if patients receive supportive care with fluids and electrolytes; maintenance of oxygenation and tissue perfusion; and respiratory, renal, and cardiovascular support. Major challenges for managing future Ebola epidemics include establishment of early and aggressive epidemic control and earlier and better patient care and treatment in remote, resource-poor areas where Ebola typically reemerges. In addition, it will be important to further develop Ebola vaccines and to adopt policies for their use in epidemic and pre-epidemic situations.

  11. Growth Factor Mediated Signaling in Pancreatic Pathogenesis

    International Nuclear Information System (INIS)

    Nandy, Debashis; Mukhopadhyay, Debabrata

    2011-01-01

    Functionally, the pancreas consists of two types of tissues: exocrine and endocrine. Exocrine pancreatic disorders mainly involve acute and chronic pancreatitis. Acute pancreatitis typically is benign, while chronic pancreatitis is considered a risk factor for developing pancreatic cancer. Pancreatic carcinoma is the fourth leading cause of cancer related deaths worldwide. Most pancreatic cancers develop in the exocrine tissues. Endocrine pancreatic tumors are more uncommon, and typically are less aggressive than exocrine tumors. However, the endocrine pancreatic disorder, diabetes, is a dominant cause of morbidity and mortality. Importantly, different growth factors and their receptors play critical roles in pancreatic pathogenesis. Hence, an improved understanding of how various growth factors affect pancreatitis and pancreatic carcinoma is necessary to determine appropriate treatment. This chapter describes the role of different growth factors such as vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), platelet derived growth factor (PDGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), and transforming growth factor (TGF) in various pancreatic pathophysiologies. Finally, the crosstalk between different growth factor axes and their respective signaling mechanisms, which are involved in pancreatitis and pancreatic carcinoma, are also discussed

  12. Pathogenesis of odontogenic cysts: an update.

    Science.gov (United States)

    Chindia, M L

    1991-04-01

    This article briefly reviews the origin, classification and pathogenesis of the various odontogenic cysts. Keratocysts and follicular cysts are said to be developmental lesions arising from the remnants of the dental lamina and the cell rests of the dental follicle respectively. The radicular cysts are the most commonly occurring lesions associated with the apices of non-vital teeth. They are said to arise from proliferation of the cell rests of Malassez in chronically inflamed granulomata. It is noted that bone resorption is the major requirement for any bony lesion to expand; hence the interest in the role of diverse cellular and chemical mediators of bone resorption in disease. The current concepts of the role, in cyst initiation and growth, of enzymes including cellular metabolites and cytokines are presented. Evidence on the activities of collagenase, arachidonic acid metabolites, leukotrienes, hydroxyeicosatetraenoic acids, interleukin--1 and prostaglandins is cited. It is observed that the understanding of these cellular and molecular biological behaviour patterns may yield more appropriate information necessary for the development of more effective management modalities for such tissue degrading lesions as odontogenic cysts.

  13. Advances in hepatitis E - I: virology, pathogenesis and diagnosis.

    Science.gov (United States)

    Aggarwal, Rakesh; Goel, Amit

    2016-09-01

    Infection with hepatitis E virus (HEV) is the commonest cause of acute hepatitis worldwide. HEV was discovered in 1980s and is known to have small non-enveloped virions with single-stranded RNA genome of positive polarity. In recent years. In recent years, availability of new information has changed our understanding of this virus and the pathogenesis of the related disease. This article reviews the current knowledge about structure, genomic organization, taxonomy, genetic epidemiology, host specificity and replication of the human HEV and of various closely-related viruses that infect other animals. In addition, the models available for the study of HEV infection, the available information on the pathogenesis of this infection and the techniques available for its diagnosis are also reviewed. Expert commentary: A circulating, enveloped form of the human HEV has been recently recognized. Originally believed to naturally infect only humans and possibly primates, HEV-like viruses are now known to infect several vertebrate animals. Based on this, phylogenetic classification of these viruses has recently been revised. In vitro replicons and infection systems have been developed, which have improved our understanding about the virus and the pathogenesis of infection with it. Recent development of mouse models with chimeric livers that contain human hepatocytes provides another avenue for further advancement of this knowledge.

  14. Diverticular Disease: An Update on Pathogenesis and Management.

    Science.gov (United States)

    Rezapour, Mona; Ali, Saima; Stollman, Neil

    2018-03-15

    Diverticular disease is one of the most common conditions in the Western world and one of the most common findings identified at colonoscopy. Recently, there has been a significant paradigm shift in our understanding of diverticular disease and its management. The pathogenesis of diverticular disease is thought to be multifactorial and include both environmental and genetic factors in addition to the historically accepted etiology of dietary fiber deficiency. Symptomatic uncomplicated diverticular disease (SUDD) is currently considered a type of chronic diverticulosis that is perhaps akin to irritable bowel syndrome. Mesalamine, rifaximin and probiotics may achieve symptomatic relief in some patients with SUDD, although their role(s) in preventing complications remain unclear. Antibiotic use for acute diverticulitis and elective prophylactic resection surgery are considered more individualized treatment modalities that take into account the clinical status, comorbidities and lifestyle of the patient. Our understanding of the pathogenesis of diverticular disease continues to evolve and is likely to be diverse and multifactorial. Paradigm shifts in several areas of the pathogenesis and management of diverticular disease are explored in this review.

  15. Implementering og anvendelse af nyere ledelsesteknologier i den kommunale sektor

    DEFF Research Database (Denmark)

    Nielsen, Steen; Nielsen, Christian

    2009-01-01

    New Public Management vedrører transformeringen af ledelse i den offentlige sektor, bl.a. ved introduktion af nye krav til de offentlige ledere, herunder at skulle stå til regnskab for ressourceforbrug, kvaliteten af de leverede ydelser, samt en fornuftig anvendelse af skatteborgernes penge. En...... central del af New Public Management bevægelsen er derfor introduktionen af nye økonomistyringsteknikker og ledelsesmodeller. Denne artikel fokuserer på kendskab, udbredelse, prioritering og nytten af sådanne tiltag i kommunalt regi, og sætter fokus på, hvorvidt økonomistyringsteknikker og...

  16. Auswirkungen oraler Carnitingaben auf den Plasmacarnitingehalt beim Warmblutpferd

    OpenAIRE

    Schnitger, Andrea

    2004-01-01

    L-Carnitin, ein körpereigenes Aminosäurederivat, ist für den zellulären Energiestoffwechsel aufgrund seiner Carrierfunktion für die freien Fettsäuren von essenzieller Bedeutung. Über eine positive Beeinflussung des Energiestoffwechsels durch die Zulage von Carnitin bestehen bislang widersprüchliche Ergebnisse. Der gesunde Organismus kann seinen Bedarf durch Eigensynthese und über die Aufnahme aus der Nahrung decken. Während der Carnitingehalt im Blut durch die Zulage von Carnitin stark erhöht...

  17. Type II canal configuration and Type I Dens invaginatus.

    Science.gov (United States)

    Liji, Mele Puthukudy; Chandrababu, Krishnankutty; Kumar, Maroli Ramesh; Jayashree, Santhadevi

    2014-07-01

    The prevalent notion about maxillary central incisor with normal external morphology is a tooth with single root and root canal. A case in which all four maxillary incisors were having Type II canal configurations (Vertucci's classification) is reported, in addition, the lateral incisors revealed dens invaginatus with a Type I pattern as suggested by Ohler's classification and a large periapical lesion was seen in relation to the right lateral incisor. The diagnosis was confirmed with the aid of spiral computed tomography (CT) and canals obturated. Nonsurgical healing of the lesion was assessed by reviewing the case at prefixed intervals of time.

  18. Bilateral dens invaginatus in the mandibular premolars - Diagnosis and treatment.

    Science.gov (United States)

    Kharangate, Nupur; Figueiredo, Nigel R; Fernandes, Marina; Lambor, Rajan

    2015-01-01

    Dens invaginatus (DI) is a developmental anomaly that results from an infolding of the dental papilla during tooth development and simulates the appearance of a tooth within another tooth. It shows a wide spectrum of variations in morphology and usually affects the maxillary lateral incisors. This study presents an unusual case of an Oehlers' Type I DI involving the bilateral mandibular first and second premolars, which presented as an incidental radiographic finding in the first premolars and was associated with a periapical lesion in the second premolars which was successfully treated using nonsurgical endodontics.

  19. Bilateral dens invaginatus in the mandibular premolars - Diagnosis and treatment

    Directory of Open Access Journals (Sweden)

    Nupur kharangate

    2015-01-01

    Full Text Available Dens invaginatus (DI is a developmental anomaly that results from an infolding of the dental papilla during tooth development and simulates the appearance of a tooth within another tooth. It shows a wide spectrum of variations in morphology and usually affects the maxillary lateral incisors. This study presents an unusual case of an Oehlers′ Type I DI involving the bilateral mandibular first and second premolars, which presented as an incidental radiographic finding in the first premolars and was associated with a periapical lesion in the second premolars which was successfully treated using nonsurgical endodontics.

  20. Millennials- Den nya och krävande generationen

    OpenAIRE

    Svensson, Josefin; Öljefors, Christine

    2014-01-01

    Psykologisk forskning visar på att unga medarbetare, den så kallade Millennialgenerationen, efterfrågar en annan typ av ledarskap än deras äldre föregångare. Syftet med studien var att undersöka unga medarbetares föreställningar om transformativt ledarskap samt i vilken utsträckning dessa föreställningar motiverar dem i arbetet. Hypotes: Transformativt ledarskap är gynnsamt för unga vuxnas motivation på arbetsplatsen jämfört med andra ledarstilar så som laissez-faire och transaktionellt ledar...

  1. Verzwickte Flussgemeinschaft - Warum es so schwierig ist, den Flüssen Raum zu geben

    NARCIS (Netherlands)

    Hartmann, T.

    2011-01-01

    Extreme Hochwasser verursachen enorme Schäden in Flusslandschaften. Flussgemeinschaften müssen künftig den Flüssen mehr Raum geben, um Hochwasser in der Fläche zurückzuhalten, statt in der Höhe (der Deiche) zu bekämpfen. Die Idee „den Flüssen mehr Raum geben“ beschreibt eigentlich etwas

  2. Der Beitrag von Erfahrungen an den Entwicklungsprozessen zur Selbständigkeit

    OpenAIRE

    Panick, Veronika

    1999-01-01

    Mit der Arbeit wird der Versuch unternommen, den Zusammenhängen von Biographie- und individuellen Lernprozessen nachzugehen. Dies erfolgt am Beispiel von acht ostdeutschen ExistenzgründerInnen, die sich nach der Wende in den neuen Bundesländern im Lebensmitteleinzelhandel selbständig gemacht haben. Hierbei interessiert die Frage, inwieweit Erfahrungen den Lernprozeß behindert oder gefördert haben. Die Ergebnisse der Arbeit bestätigen die hohe Relevanz von Erfahrungen, Handlungsmustern und V...

  3. Endodontic treatment of immature maxillary lateral incisor with two canals: type 3 dens invaginatus.

    Science.gov (United States)

    Altuntaş, Alev; Cınar, Cağdaş; Akal, Neşe

    2010-10-01

    Dens invaginatus is a developmental anomaly. The nonsurgical endodontic treatment of a type 3 dens invaginatus with a large periradicular lesion in a maxillary left lateral incisor of a 10-year-old girl is presented. In spite of difficult diagnosis and treatment of type 3 dens invaginatus, nonsurgical treatment was performed successfully. Resolution of the periradicular lesion and apical closure was observed after 1-year follow-up. Copyright © 2010 Mosby, Inc. All rights reserved.

  4. Assessment of the prevalence and characteristics of dens invaginatus in a sample of Turkish Anatolian population

    OpenAIRE

    Cakici, Fatih; Celikoglu, Mevlut; Arslan, Hakan; Topcuoglu, H. Sinan; Erdogan, Aziz Sahin

    2010-01-01

    Objective: The objective of this study was to assess the prevalence and characteristics of dens invaginatus in anterior teeth and to classify the type of dens invaginatus in a sample of Turkish Anatolian population. Study design: A retrospective study was performed using full-mouth periapical and panoramic radiographs of 1012 patients. Maxillary and mandibular anterior teeth were evaluated for the presence and characteristics of dens invaginatus. Statistical evaluation of the presence of ...

  5. Küsten und Klimawandel in den Augen von Touristen : eine Wahrnehmungsanalyse an der deutschen Ostsee

    OpenAIRE

    Hallermeier, Larissa Diane

    2011-01-01

    Aufgrund seiner wirtschaftlichen Bedeutung spielt der Tourismus in Mecklenburg-Vorpommern eine große Rolle. Insbesondere die Küstengebiete sind beliebte Reiseziele. In den letzten Jahren konnte ein kontinuierlicher Anstieg der Ankünfte und Übernachtungen verzeichnet werden. Neben anderen Faktoren werden die regionalen Auswirkungen des Klimawandels jedoch in Zukunft eine Herausforderung für den Tourismussektor darstellen. Die globale Erwärmung wird für den Strand- und Badetourismus sowohl nega...

  6. Den økonomiske teoris rødder - fra Aristoteles til Lucas

    DEFF Research Database (Denmark)

    Olesen, Finn; Pedersen, Kurt

    I denne bog, "Den økonomiske teoris rødder - fra Aristoteles til Lucas", belyses den økonomiske teoris udvikling fra de første spæde græske forsøg godt 400 år f. Kr. helt op til vores egen samtid med en præsentation af moderne makroteori. Samtidig forsøger fremstillingen at sætte den økonomiske...

  7. Multiple pathways contribute to the pathogenesis of Huntington disease

    Directory of Open Access Journals (Sweden)

    Li Xiao-Jiang

    2006-12-01

    Full Text Available Abstract Huntington disease (HD is caused by expansion of a polyglutamine (polyQ domain in the protein known as huntingtin (htt, and the disease is characterized by selective neurodegeneration. Expansion of the polyQ domain is not exclusive to HD, but occurs in eight other inherited neurodegenerative disorders that show distinct neuropathology. Yet in spite of the clear genetic defects and associated neurodegeneration seen with all the polyQ diseases, their pathogenesis remains elusive. The present review focuses on HD, outlining the effects of mutant htt in the nucleus and neuronal processes as well as the role of cell-cell interactions in HD pathology. The widespread expression and localization of mutant htt and its interactions with a variety of proteins suggest that mutant htt engages multiple pathogenic pathways. Understanding these pathways will help us to elucidate the pathogenesis of HD and to target therapies effectively.

  8. Persistent perineal sinus. Incidence, pathogenesis, risk factors, and management

    International Nuclear Information System (INIS)

    Lohsiriwat, V.

    2009-01-01

    This review discusses the incidence, pathogenesis, risk factors, diagnosis, and therapeutic options for persistent perineal sinus (PPS), defined as a perineal wound that remains unhealed more than 6 months after surgery. The incidence of PPS after surgery for inflammatory bowel disease (IBD) ranges from 3% to 70% and after abdominoperineal resection (APR) for Low rectal cancer, it can be up to 30%. These unhealed wounds are frequently related to perioperative pelvic or perineal sepsis. Crohn's disease (CD) and neoadjuvant radiation therapy are also important risk factors. The management of PPS is based on an understanding of pathogenesis and clinical grounds. The advantages and disadvantages of the current therapeutic approaches, including the topical administration of various drugs, vacuum-assisted closure, and perineal reconstruction with a muscle flap or a myocutaneous flap are also discussed. (author)

  9. Animal Models of Zika Virus Infection, Pathogenesis, and Immunity.

    Science.gov (United States)

    Morrison, Thomas E; Diamond, Michael S

    2017-04-15

    Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that now causes epidemics affecting millions of people on multiple continents. The virus has received global attention because of some of its unusual epidemiological and clinical features, including persistent infection in the male reproductive tract and sexual transmission, an ability to cross the placenta during pregnancy and infect the developing fetus to cause congenital malformations, and its association with Guillain-Barré syndrome in adults. This past year has witnessed an intensive effort by the global scientific community to understand the biology of ZIKV and to develop pathogenesis models for the rapid testing of possible countermeasures. Here, we review the recent advances in and utility and limitations of newly developed mouse and nonhuman primate models of ZIKV infection and pathogenesis. Copyright © 2017 American Society for Microbiology.

  10. MicroRNAs in the Cholangiopathies: Pathogenesis, Diagnosis, and Treatment

    Directory of Open Access Journals (Sweden)

    Maria Jose Lorenzo Pisarello

    2015-08-01

    Full Text Available The cholangiopathies are a group of liver diseases resulting from different etiologies but with the cholangiocyte as the primary target. As a group, the cholangiopathies result in significant morbidity and mortality and represent one of the main indications for liver transplant in both children and adults. Contributing to this situation is the absence of a thorough understanding of their pathogenesis and a lack of adequate diagnostic and prognostic biomarkers. MicroRNAs are small non-coding RNAs that modify gene expression post-transcriptionally. They have been implicated in the pathogenesis of many diseases, including the cholangiopathies. Thus, in this review we provide an overview of the literature on miRNAs in the cholangiopathies and discuss future research directions.

  11. Genes, autoimmunity and pathogenesis of rheumatic heart disease

    International Nuclear Information System (INIS)

    Guilherme, L; Köhler, K F; Postol, E; Kalil, J

    2011-01-01

    Pathogenesis of rheumatic heart disease (RHD) remains incompletely understood. Several genes associated with RHD have been described; most of these are involved with immune responses. Single nucleotide polymorphisms in a number of genes affect patients with RHD compared to controls. Molecular mimicry between streptococcal antigens and human proteins, including cardiac myosin epitopes, vimentin and other intracellular proteins is central to the pathogenesis of RHD. Autoreactive T cells migrate from the peripheral blood to the heart and proliferate in the valves in response to stimulation with specific cytokines. The types of cells involved in the inflammation as well as different cytokine profiles in these patients are being investigated. High TNF alpha, interferon gamma, and low IL4 are found in the rheumatic valve suggesting an imbalance between Th1 and Th2 cytokines and probably contributing to the progressive and permanent valve damage. Animal model of ARF in the Lewis rat may further contribute towards understanding the ARF

  12. Den ecology of Octopus vulgaris Cuvier, 1797, on soft sediment: availability and types of shelter

    Directory of Open Access Journals (Sweden)

    Stelios Katsanevakis

    2004-03-01

    Full Text Available To avoid predation, octopuses select and actively modify shelters (also called dens in the substratum, where they remain most of the time, especially during daylight hours. The main questions that this study deals with are: Is den availability a significant constraint for the distribution of Octopus vulgaris on soft sediment? What kind of dens does O. vulgaris use on soft sediment and what factors affect the selection of one type instead of another? With population density measurements by SCUBA diving and enrichment experiments with artificial dens, we concluded that the availability of solid materials necessary for den construction is a limiting factor for the distribution of O. vulgaris on soft sediment. O. vulgaris used four different types of den on soft sediment: well (a vertical hole in the sediment, rock/stone (the octopus uses a rock or a large stone to dig a cavity under it, shell (an empty shell is used, human origin (a solid material of human origin is used. The relative proportion of the four types of den in the areas studied was: 38.7% human origin, 29.7% well, 21.5% rock/stone, 2.9% shell. Also, 7.3% of the octopuses were found outside their den. The main types of den were found in different relative proportions in relation to the depth, the distance from shore, the octopus size and the granulometry of the sediment.

  13. Forskere giver opskriften på den perfekte lærer

    DEFF Research Database (Denmark)

    Fugl, Marie

    2008-01-01

    Et tæt forhold til den enkelte elev. Evnen til at lede en klasse. Og et vist mål faglig dygtighed. Det er ingredienserne i den gode lærer, der får gode resultater hos eleverne. Interview med professor Sven Erik Nordenbo. Udgivelsesdato: Juni......Et tæt forhold til den enkelte elev. Evnen til at lede en klasse. Og et vist mål faglig dygtighed. Det er ingredienserne i den gode lærer, der får gode resultater hos eleverne. Interview med professor Sven Erik Nordenbo. Udgivelsesdato: Juni...

  14. MANAGEMENT OF DENS INVAGINATUS TYPE II WITH PERIAPICAL LESION: CASE REPORT*

    Directory of Open Access Journals (Sweden)

    İsmail Uzun

    2015-10-01

    Full Text Available Dens invaginatus is a developmental anomaly resulting from epithelial invagination of the tooth crown before calcification. Endodontic treatment of teeth affected by dens invaginatusmay be difficult and complex due to aberrant anatomy. Combined orthograde and surgical approaches for successful treatment of dens invaginatus are effective. This report describes the successful treatmentand results atthe 12-month follow-up of a maxillary lateral incisor showing dens invaginatus type II, a large periapical lesion and an open apex by using combined surgical and endodontic treatment.

  15. The prevalence of anterior teeth with dens invaginatus in the western Mediterranean region of Turkey.

    Science.gov (United States)

    Kirzioğlu, Z; Ceyhan, D

    2009-08-01

    To assess the prevalence and type of dens invaginatus in anterior teeth of a selected population and to report associated dental complications. The records of patients examined in the Department of Paedodontics, Faculty of Dentistry, Süleyman Demirel University, Isparta, Turkey between 1999 and 2006 were screened and a total of 2477 patients who had complete records with satisfactory radiographs were selected. The type of dens invaginatus and the presence of apical pathosis was determined from radiographs. Other dental abnormalities, syndromes and systemic diseases were noted. Variations in crown shape were also recorded. Dens invaginatus was detected in 300 out of 2477 patients, with a prevalence of 12%; 82% of affected patients had dens invaginatus bilaterally. Maxillary lateral incisors were the most affected teeth. The majority of the teeth had normal crown morphology (95%). The most commonly seen type of dens invaginatus was type I (94%). Overall 33% of the patients with type III dens invaginatus and 4% of the patients with type II dens invaginatus had apical pathosis. No associations with other systemic diseases and syndromes and some limited association with hypodontia and dens evaginatus were detected. A careful oral examination, radiographs, a suitable treatment plan and follow-up programme are crucial for early diagnosis and treatment for teeth with dens invaginatus.

  16. Teaching Teaching & Understanding Understanding

    DEFF Research Database (Denmark)

    2006-01-01

    "Teaching Teaching & Understanding Understanding" is a 19-minute award-winning short-film about teaching at university and higher-level educational institutions. It is based on the "Constructive Alignment" theory developed by Prof. John Biggs. The film delivers a foundation for understanding what...

  17. Effekte oraler Vitamin-B12-Substitution auf den Stoffwechsel und den Gesundheitsstatus bei Milchkühen

    OpenAIRE

    Obitz, Kristin

    2015-01-01

    Einleitung: Vitamin B12 hat wichtige Funktionen im Energiestoffwechsel sowie bei der Erythropoese. Beide Funktionskreise werden bei Hochleistungskühen besonders beansprucht und können bei Belastungen und ungenügender Vitamin-B12-Versorgung Ausgangspunkt für klinische Störungen werden. Ziele der Untersuchungen: In den vorliegenden Studien wurde der Fragestellung nachgegangen, wie sich die Vitamin-B12-Konzentration im Blutserum von Milchkühen in der Frühlaktation verhält und welche Zusammen...

  18. Digital kommunikation med den offentlige sektor: Styrelser og statslige institutioner

    DEFF Research Database (Denmark)

    Berger, Jesper Bull; Andersen, Kim Normann

    digital postkasse, som borgerne kunne skrive til. I denne undersøgelse sættes der fokus på myndighedernes besvarelse af den digitale post. Digital post blev bl.a. etableret som et alternativ til almindelig e-mail for at det offentlige kan kommunikere med borgere og virksomheder på en sikker måde, dvs....... uden at uvedkommende kan få adgang til følsomme oplysninger. Fokus for undersøgelsen er hvordan håndterer myndighederne besvarelserne i den digitale postkasse: svarer de på digital post og e-mail, hvor hurtigt svarer de og er svarene brugbare? Vi har også undersøgt besvarelse af e-mail, dels...... for at kunne sammenligne de to digitale kanaler og for at kunne sammenligne med en tidligere undersøgelse af digital kommunikation med det offentlige. Herudover er der tidligere gennemført en undersøgelse af e-mail svar og svartider i New Zealand og Australien. De danske resultater fra e-mail undersøgelsen...

  19. AC-arbejdskraft i den vestlige del af Region Midtjylland

    DEFF Research Database (Denmark)

    Filges, Trine; Holt, Helle

    Denne rapport belyser muligheder og barrierer for AC-arbejdskraft i den vestlige del af Region Midtjylland. Undersøgelsen viser, at ca. 8 pct. af virksomhederne, der indgår i undersøgelsen, på interviewtidspunktet ønsker at rekruttere AC-arbejdskraft inden for 6 måneder. Undersøgelsen viser desuden......, at mange af virksomhederne forventer, at AC’eren møder på arbejdspladsen hver dag – og gerne, at de flytter til lokalområdet. Virksomhederne vurderer, at det er en barriere, at AC’erne har svært ved at se en videre karriere i lokalområdet, og at de foretrækker at pendle til arbejdspladsen. Dårlig...... infrastruktur nævnes i den forbindelse også som en barriere. Undersøgelsen bygger på en spørgeskemaundersøgelse blandt virksomheder i kommunerne: Lemvig, Holstebro, Herning, Ringkøbing-Skjern og Struer. Undersøgelsen er bestilt af Beskæftigelsesregion Midtjylland og er finansieret af Region Midtjylland og...

  20. Videnskabsteorien og den reflekterende dømmekraft

    DEFF Research Database (Denmark)

    Jørgensen, Klaus Frovin

    2007-01-01

    I denne artikel diskuterer jeg Immanuel Kants videnskabssyn, som det tager sig ud i Kritik af dømmekraften. Udgangspunktet er erkendelsesteorien og i særdeleshed den såkaldte skemateori. For Kant findes der rene videnskaber og empiriske videnskaber. De rene videnskabers begreber er karakteriseret...... instrumentalisme, der hersker. Der er visse subjektive principper og maximer, som er mere ’naturlige’ og ’rigtige’ end andre. Kants typiske eksempler herpå er ideen om fuldstændig enhed af den videnskabelige erkendelse og ideen om teleologi i naturen – at intet i naturen er tilfældigt, og at alt har et formål....... Artiklen afsluttes ved at perspektivere og sammenstille Kants videnskabsfilosofi med Thomas Kuhns nutidige videnskabsteori. Jeg argumenterer for, at Kants og Kuhns teorier har fundamentale elementer og strukturer til fælles, og at de vigtigste fornuftsmæssige ideer og principper hos Kant går igen i Kuhns...

  1. Bilateral dens invaginatus in the mandibular premolar region

    Directory of Open Access Journals (Sweden)

    Canger Emin

    2009-01-01

    Full Text Available Dens invaginatus (dens in dente, DI is a rare developmental anomaly resulting from invagination of a portion of the crown rare. It is an important dental anomaly due to the possible pulpal involvement. DI can be detected clinically in a tooth presenting unusual crown morphology or having deep foramen coaceum. Also, clinically, non-suspected affected teeth are commonly diagnosed as an incidental radiographic finding. Presence of DI in the mandibular premolar teeth is unusual. Aims is to introduce a case of bilateral occurrence of DI in mandibular first premolar teeth. A 33- year-old man was referred to our clinic with a chief complaint of severe pain in his lower third molar tooth. Radiographic examination revealed bilateral DI (single at the left, double at the right in mandibular first premolar teeth. The teeth were restored with fissure sealant. Although bilateral appearance of DI is a frequent situation, mandibular occurrence is very rare. Our review of the literature reveals just nine cases of DI, and only one of them is in a premolar tooth.

  2. Der chthonische Dionysos - Zur Wirkmacht des Mythos in den Mysterien

    Directory of Open Access Journals (Sweden)

    Niklas Engel

    2016-12-01

    Full Text Available Dieser Beitrag soll aufzeigen, dass eine chthonische und eschatologische Dimension der dionysischen Göttlichkeit in verschiedenen Riten und Kulten des Gottes nachgewiesen werden kann und dabei keinesfalls mysterienexklusiv ist. Dazu soll der archäologische Befund, der Dionysos mit dem Jenseits und eschatologischen Ho nungen in Verbindung bringt, vorgestellt und untersucht werden. Darauf aufbauend soll belegt werden, dass diese jenseitige Dimension sich sowohl in Riten mit privatem Kern, hier am Beispiel der Oreibasia, als auch in Kultfeiern des ö entlichen Festkanons, wie den Anthesterien, zeigt. Abschließend soll dann Dionysos‘ Funktion in den eleusinischen Mysterien untersucht werden. This paper aims to show that a chthonic and eschatological dimension of dionysiac divinity can be found in various rites and cults of the god and that this is not exclusive for the mysteries. Recent archaeological evidence connecting Dionysos with the afterlife and eschatological expectations will be introduced and analyzed. is dimension manifests itself in rites with a private intent (e.g. the Oreibasia as well as public celebrations of the festival calendar (e.g. the Anthesteria. An analysis of Dionysos’ function in the eleusinian mysteries concludes the overview.

  3. Autophagy in lung disease pathogenesis and therapeutics

    Directory of Open Access Journals (Sweden)

    Stefan W. Ryter

    2015-04-01

    Full Text Available Autophagy, a cellular pathway for the degradation of damaged organelles and proteins, has gained increasing importance in human pulmonary diseases, both as a modulator of pathogenesis and as a potential therapeutic target. In this pathway, cytosolic cargos are sequestered into autophagosomes, which are delivered to the lysosomes where they are enzymatically degraded and then recycled as metabolic precursors. Autophagy exerts an important effector function in the regulation of inflammation, and immune system functions. Selective pathways for autophagic degradation of cargoes may have variable significance in disease pathogenesis. Among these, the autophagic clearance of bacteria (xenophagy may represent a crucial host defense mechanism in the pathogenesis of sepsis and inflammatory diseases. Our recent studies indicate that the autophagic clearance of mitochondria, a potentially protective program, may aggravate the pathogenesis of chronic obstructive pulmonary disease by activating cell death programs. We report similar findings with respect to the autophagic clearance of cilia components, which can contribute to airways dysfunction in chronic lung disease. In certain diseases such as pulmonary hypertension, autophagy may confer protection by modulating proliferation and cell death. In other disorders, such as idiopathic pulmonary fibrosis and cystic fibrosis, impaired autophagy may contribute to pathogenesis. In lung cancer, autophagy has multiple consequences by limiting carcinogenesis, modulating therapeutic effectiveness, and promoting tumor cell survival. In this review we highlight the multiple functions of autophagy and its selective autophagy subtypes that may be of significance to the pathogenesis of human disease, with an emphasis on lung disease and therapeutics.

  4. Post-den emergence behavior of polar bears (Ursus maritimus) in Northern Alaska

    Science.gov (United States)

    Smith, T.S.; Partridge, Steven T.; Amstrup, Steven C.; Schliebe, S.

    2007-01-01

    We observed polar bear (Ursus maritimus) maternity den sites on Alaska’s North Slope in March 2002 and 2003 in an effort to describe bears’ post-den emergence behavior. During 40 sessions spanning 459 h, we observed 8 adults and 14 dependent cubs outside dens for 37.5 h (8.2% of total observation time). There was no significant difference between den emergence dates in 2002 (mean = 15 Mar ± 4.1 d) and 2003 (mean = 21 Mar ± 2.1 d). Following initial den breakout, polar bears remained at their den sites for 1.5 to 14 days (mean = 8.1 ± 5.1 d). The average length of stay in dens between emergent periods was significantly shorter in 2002 (1.79 h) than in 2003 (4.82 h). While outside, adult bears were inactive 49.5% of the time, whereas cubs were inactive 13.4% of the time. We found no significant relationships between den emergence activity and weather. Adult polar bears at den sites subjected to industrial activity exhibited significantly fewer bouts of vigilance than denned bears in undisturbed areas (t = -5.5164, df = 4, p= 0.00). However, the duration of vigilance behaviors at sites near industrial activity was not significantly shorter than at the other sites studied (t = -1.8902, df = 4, p = 0.07). Results for these bears were within the range of findings in other studies of denned polar bears.

  5. Den nyeste indsigt i praeeklampsiens aetiologi og patogenese

    DEFF Research Database (Denmark)

    Hviid, U R; Hviid, T V

    2000-01-01

    Pre-eclampsia is a major cause of maternal and foetal morbidity and mortality but the etiology and pathogenesis are basically unknown. Pre-eclampsia is clearly associated to the placenta (trophoblast) alone. Epidemiological observations have raised one of the most popular hypotheses of the genesi...

  6. Pathogenesis of Noroviruses, Emerging RNA Viruses

    Directory of Open Access Journals (Sweden)

    Stephanie M. Karst

    2010-03-01

    Full Text Available Human noroviruses in the family Caliciviridae are a major cause of epidemic gastroenteritis. They are responsible for at least 95% of viral outbreaks and over 50% of all outbreaks worldwide. Transmission of these highly infectious plus-stranded RNA viruses occurs primarily through contaminated food or water, but also through person-to-person contact and exposure to fomites. Norovirus infections are typically acute and self-limited. However, disease can be much more severe and prolonged in infants, elderly, and immunocompromised individuals. Norovirus outbreaks frequently occur in semi-closed communities such as nursing homes, military settings, schools, hospitals, cruise ships, and disaster relief situations. Noroviruses are classified as Category B biodefense agents because they are highly contagious, extremely stable in the environment, resistant to common disinfectants, and associated with debilitating illness. The number of reported norovirus outbreaks has risen sharply since 2002 suggesting the emergence of more infectious strains. There has also been increased recognition that noroviruses are important causes of childhood hospitalization. Moreover, noroviruses have recently been associated with multiple clinical outcomes other than gastroenteritis. It is unclear whether these new observations are due to improved norovirus diagnostics or to the emergence of more virulent norovirus strains. Regardless, it is clear that human noroviruses cause considerable morbidity worldwide, have significant economic impact, and are clinically important emerging pathogens. Despite the impact of human norovirus-induced disease and the potential for emergence of highly virulent strains, the pathogenic features of infection are not well understood due to the lack of a cell culture system and previous lack of animal models. This review summarizes the current understanding of norovirus pathogenesis from the histological to the molecular level, including

  7. Obesity Pathogenesis: An Endocrine Society Scientific Statement.

    Science.gov (United States)

    Schwartz, Michael W; Seeley, Randy J; Zeltser, Lori M; Drewnowski, Adam; Ravussin, Eric; Redman, Leanne M; Leibel, Rudolph L

    2017-08-01

    Obesity is among the most common and costly chronic disorders worldwide. Estimates suggest that in the United States obesity affects one-third of adults, accounts for up to one-third of total mortality, is concentrated among lower income groups, and increasingly affects children as well as adults. A lack of effective options for long-term weight reduction magnifies the enormity of this problem; individuals who successfully complete behavioral and dietary weight-loss programs eventually regain most of the lost weight. We included evidence from basic science, clinical, and epidemiological literature to assess current knowledge regarding mechanisms underlying excess body-fat accumulation, the biological defense of excess fat mass, and the tendency for lost weight to be regained. A major area of emphasis is the science of energy homeostasis, the biological process that maintains weight stability by actively matching energy intake to energy expenditure over time. Growing evidence suggests that obesity is a disorder of the energy homeostasis system, rather than simply arising from the passive accumulation of excess weight. We need to elucidate the mechanisms underlying this "upward setting" or "resetting" of the defended level of body-fat mass, whether inherited or acquired. The ongoing study of how genetic, developmental, and environmental forces affect the energy homeostasis system will help us better understand these mechanisms and are therefore a major focus of this statement. The scientific goal is to elucidate obesity pathogenesis so as to better inform treatment, public policy, advocacy, and awareness of obesity in ways that ultimately diminish its public health and economic consequences. Copyright © 2017 Endocrine Society.

  8. Den koreanske bølgen - En kulturvitenskapelig studie av sørkoreansk populærkultur, og hvordan den har nådd Vesten

    OpenAIRE

    Kvinge, Kristin Øyvindsdatter

    2016-01-01

    Hensikten med denne oppgaven er å se på den koreanske bølgen, som ofte refereres til som Hallyu. Den tar for seg både Hallyu som innhold og Hallyu som fenomen. Den koreanske bølgen har spredd seg hurtig i løpet av de siste 20 årene, noe som har bidratt til å gjøre Korea til en av de hurtigst økende økonomiene i den moderne tid. Denne oppgaven forsøker å se nærmere på hvordan Hallyu har nådd Vesten, med fokus på Europa og Norge. Før analysen vil oppgaven se nærmere på hv...

  9. [Raynaud's phenomenon: pathogenesis and prevalence].

    Science.gov (United States)

    Mikulska, Danuta

    2010-01-01

    Raynaud's phenomenon is defined as occasional ischemia of the distal parts of the extremities. Ischemia may be idiopathic as in primary Raynaud's disease or instigated by a comorbidity as in Raynaud's syndrome. Opinions on the etiopathogenesis of Raynaud's phenomenon have changed during recent years. Research has shown that enhanced vascular reactivity is attributable more to local factors and less to abnormalities in the central nervous system. Local factors are classified as vascular, nervous, and intravascular. Changes in our understanding of the etiopathogenesis of Raynaud's phenomenon have resulted in modified therapeutic guidelines. The present work reviews current opinions on the etiopathogenesis of Raynaud's phenomenon.

  10. Iron to fight the climate collapse. Can algae stem the greenhouse effect?; Eisen gegen den Klimakollaps. Algen gegen den Treibhauseffekt?

    Energy Technology Data Exchange (ETDEWEB)

    Kobbe, B.

    1996-10-01

    This article in popular language describes investigations regarding a possible relationship between phytoplankton growth and the iron content of oceans. Upon aimed ``fertilization`` of an area of 100 square kilometres in the region of the Galapagos islands with 500 kilogrammes of dissolved iron sulfate, an increase in chlorophyll occurring in phytoplankton by a factor of 30 was found in that area. The question is discussed of whether the resulting lowering of the carbon dioxide concentration on a global scale could be a solution to the greenhouse problem. (FK) [Deutsch] Dieser allgemeinverstaendliche Artikel stellt aktuelle Untersuchungen ueber einen moeglichen Zusammenhang zwischen dem Wachstum des Phytoplanktons und dem Eisengehalt der Ozeane dar. Nach gezielter `Duengung` eines 100 km{sup 2} grossen Areals im Gebiet der Galopagos-Inseln mit 500 kg geloestem Eisensulfat wurde dort eine Zunahme des im Phytoplankton vorkommenden Chlorophylls um den Faktor 30 festgestellt. Es wird diskutiert, ob die daraus folgende Absenkung der CO{sub 2}-Konzentration in globalem Massstab eine Loesung fuer den Treibhaus-Effekt sein kann. (FK)

  11. The pathogenesis, diagnosis and treatment of Raynaud phenomenon.

    Science.gov (United States)

    Herrick, Ariane L

    2012-08-01

    The past 10 years have seen the publication of results from several multicentre clinical trials in primary and systemic sclerosis (SSc)-related Raynaud phenomenon. The publication of these studies has occurred as a result of new insights into the pathogenesis of Raynaud phenomenon, which are directing new treatment approaches, and increased international collaboration between clinicians and scientists. Although the pathogenesis of Raynaud phenomenon is complex, abnormalities of the blood vessel wall, of neural control mechanisms and of intravascular (circulating) factors are known to interact and contribute. Key players relevant in drug development include nitric oxide, endothelin-1, alpha adrenergic receptor activation, abnormal signal transduction in vascular smooth muscle, oxidative stress and platelet activation. The main advances in diagnosis have been a clearer understanding of autoantibodies and of abnormal nailfold capillary patterns as independent predictors of SSc, and widespread use and increased availability of capillaroscopy. The ultimate aim is to translate the advances made in the pathophysiology and early diagnosis into development of treatments to prevent and reverse digital vascular dysfunction and injury. This Review provides an update of the pathogenesis, diagnosis and treatment of Raynaud phenomenon. Current and future treatment approaches are discussed, and some key unanswered questions are highlighted.

  12. Update of enterovirus 71 infection: epidemiology, pathogenesis and vaccine.

    Science.gov (United States)

    Wang, Shih-Min; Liu, Ching-Chuan

    2014-04-01

    Enterovirus 71 (EV71) is a neurotropic human pathogen that is the causative agent of hand foot and mouth disease (HFMD), herpangina and brain stem encephalitis. Recurrent EV71 epidemics of various scales have occurred in the Asia-Pacific region. Several specific cell surface molecules serve as the receptors for EV71. Identification of the receptors is an important step to understand EV71 disease. Cytokines, lymphocytes and monocytes contribute significantly to EV71 pathogenesis. The interaction of EV71 and receptors may be associated with the cytokines immunopathogenesis. Some animal models have been established and aim to explore the pathogenesis of EV71 infections. EV71 antibodies can neutralize or enhance infection at subneutralizing levels. These results are important for EV71 vaccine and therapeutics design. Several clinical trials of human inactivated EV71 vaccine have recently been completed. The purpose of this review is to summarize recent discoveries about the epidemiology and pathogenesis of EV71 and provide insights into human vaccine development.

  13. Den Europæiske union er på vej mod at udvikle og implementere europæiske regnskabsstandarder indenfor den offentlige sektor (EPSAS)

    DEFF Research Database (Denmark)

    Pontoppidan, Caroline Aggestam

    2013-01-01

    I maj 2013 var Europa-Kommissionen og Eurostat vært for en konference med formålet at forhandle om den fremtidige udvikling af harmoniserede offentlige regnskabsstandarder (European Public Sector Stardards' EPSAS), som skal anvendes af alle medlemslande i den Europæiske Union. Konfererencen, som ...... blev holdt i Bryssel, samlede internationale organisatoner såsom International Federation of Accountants (FAC), Verdensbanken og International Monetary Fund (IMF) samt interessenter og beslutningstagere fra EU's medlemslande....

  14. 1/49 der einfluss und die stellung des völkerrechts in den ...

    African Journals Online (AJOL)

    Dr Tanya du Plessis

    25. Sept. 2008 ... den früher sozialistischen Staaten Mittel- und Osteuropas eine Art Tabu. Die. Angst vor dem Geist und der Wirkung völkerrechtlicher Instrumente, der ideologische Kampf und vor allem die Sorge um den Schutz der staatlichen. Souveränität verhinderten über Jahrzehnte hinweg das wirkliche Eindringen.

  15. Den site activity patterns of adult male and female swift foxes, Vulpes velox, in Northwestern Texas

    Science.gov (United States)

    Lemons, P.R.; Ballard, W.B.; Sullivan, R.M.; Sovada, M.A.

    2003-01-01

    Activity of Swift Foxes (Vulpes velox) at den sites was studied in northwestern Texas during pup rearing seasons in 2000 and 2001 to determine role of males in parental care. Twenty-four percent of radio-collared females with a potential to breed successfully raised pups to eight weeks of age. We intensively monitored presence and absence of male and female Swift Foxes at two den sites each year. Females were present >2.6 times more at den sites than males during the pup rearing season. Female and male Swift Foxes largely stayed at dens during diurnal hours and were active away from dens during nocturnal and crepuscular hours. Females and males spent 12.4% and 3.0% more time at dens before pups emerged, than after pups emerged, respectively. Following depredation of one male parent, the female spent 29% less time at the den site. Decrease in time spent at the den by the female following loss of her mate suggested that loss of one parent might severely impact recruitment of Swift Foxes. Our observations indicated that intense Coyote (Canis latrans) depredation may severely impact pup-rearing success as well as the parental care within Swift Fox family groups.

  16. Zur Frage der Zähmung des Onager bei den alten Sumerern

    NARCIS (Netherlands)

    Antonius, Otto

    1939-01-01

    Die Veröffentlichung von zwei neuen Funden aus dem Zweistromlande (1, 2, 3) ist geeignet, mehr Licht auf die viel umstrittene Frage zu werfen, welcher Art die von den alten Sumerern im dritten vorchristlichen Jahrtausend als Zugtiere vor den Kriegswagen verwendeten Einhufer angehört haben.

  17. Chlorerede opløsningsmidler i den mættede zone

    DEFF Research Database (Denmark)

    Broholm, K.

    1996-01-01

    Anmeldelse af Jensen,B.K. & Nilsson,B.: Chlorerede opløsningsmidler i den mættede zone. Miljøstyrelsen 1996, (Miljøprojekt 330)......Anmeldelse af Jensen,B.K. & Nilsson,B.: Chlorerede opløsningsmidler i den mættede zone. Miljøstyrelsen 1996, (Miljøprojekt 330)...

  18. Wind interviewet til Berlingske om den stigningen opbakning til EU blandt danskerne

    DEFF Research Database (Denmark)

    Wind, Marlene

    2017-01-01

    Professor og centerleder, Marlene Wind, var tirsdag den 11. juli interviewet til Berlingske om den stigende opbakning til EU blandt danskerne. Wind forklarer blandt andet stigningen med de igangværende Brexit forhandlinger, men også at truslen fra Rusland er med til at forstærke opbakningen til EU...

  19. Polar bear maternal den habitat in the Arctic National Wildlife Refuge, Alaska

    Science.gov (United States)

    Durner, George M.; Amstrup, Steven C.; Ambrosius, Ken J.

    2006-01-01

    Polar bears (Ursus maritimus) give birth during mid-winter in dens of ice and snow. Denning polar bears subjected to human disturbances may abandon dens before their altricial young can survive the rigors of the Arctic winter. Because the Arctic coastal plain of Alaska is an area of high petroleum potential and contains existing and planned oil field developments, the distribution of polar bear dens on the plain is of interest to land managers. Therefore, as part of a study of denning habitats along the entire Arctic coast of Alaska, we examined high-resolution aerial photographs (n = 1655) of the 7994 km2 coastal plain included in the Arctic National Wildlife Refuge (ANWR) and mapped 3621 km of bank habitat suitable for denning by polar bears. Such habitats were distributed uniformly and comprised 0.29% (23.2 km2) of the coastal plain between the Canning River and the Canadian border. Ground-truth sampling suggested that we had correctly identified 91.5% of bank denning habitats on the ANWR coastal plain. Knowledge of the distribution of these habitats will help facilitate informed management of human activities and minimize disruption of polar bears in maternal dens.

  20. Habitat characteristics at den sites of the Point Arena mountain beaver (Aplodontia rufa nigra)

    Science.gov (United States)

    William J. Zielinski; John E. Hunter; Robin Hamlin; Keith M. Slauson; M. J. Mazurek

    2010-01-01

    The Point Arena mountain beaver (Aplodontia rufa nigra) is a federally listed endangered species, but has been the subject of few studies. Mountain beavers use burrows that include a single subterranean den. Foremost among the information needs for this subspecies is a description of the above-ground habitat features associated with dens. Using...

  1. Den Dansk-Engelske Regnskabsordbog/Danish-English Dictionary of Accounting

    DEFF Research Database (Denmark)

    Nielsen, Sandro; Mourier, Lise; Bergenholtz, Henning

    Den Dansk-Engelske Regnskabsordbog. Hver af ordbøgerne har 4.100 opslagsord og ca. 15.000 ordforbindelser. Ordbøgerne bygger primært på den gældende danske årsregnskabslov, danske regnskabsvejledninger og internationale regnskabsstandarder (IAS/IFRS)....

  2. Læringsfremmende evaluering i den lægelige videreuddannelse

    DEFF Research Database (Denmark)

    Madsen, Bjørn; Klitmøller, Anders

    2011-01-01

    Denne statusartikel omhandler evaluering af læger, og hvorledes evaluering kan anvendes som en læringsfremmende foranstaltning. Fokus i artiklen er på den formelle evaluering, som den kommer til udtryk i de kliniske vejledersamtaler. Da de fleste læger i deres karriere fungerer som vejleder, er d...

  3. Dens invaginatus in primary maxillary molar: a rare case report and review of literature.

    Science.gov (United States)

    Bansal, Arpana V; Bansal, Abhinav; Kulkarni, Vinaya Kumar; Dhar, Reema Sharma

    2012-05-01

    Dens invaginatus is a rare developmental anomaly. It is unusual to find this anomaly in primary dentition. Diagnosis of this dens invaginatus is important due to possible pulpal involvement. Not only that, simultaneous presence of other dental anomaly may require long-term treatment planning. Dens invaginatus can be detected clinically in the tooth presenting unusual crown morphology or radiographically as radiopacity within tooth. This article describes one of the first case reports of dens invaginatus in primary maxillary second molar in a 5-year-old female patient. How to cite this article: Bansal AV, Bansal A, Kulkarni VK, Dhar RS. Dens Invaginatus in Primary Maxillary Molar: A Rare Case Report and Review of Literature. Int J Clin Pediatr Dent 2012;5(2):139-141.

  4. Types and forms of sleeping dens of pacas (Cuniculus paca in the upper Itaya river basin

    Directory of Open Access Journals (Sweden)

    Rolando Aquino

    2012-10-01

    Full Text Available This report deals with paca sleeping dens (Cuniculus paca Linnaeus, 1766. The study was conducted between August 2006 and April 2007 and is based on detailed observations. Results indicate that this rodent uses holes in the ground or in fallen trees as sleeping dens. Each of these sleeping dens had two or more orifices and an internal cavity for the "diurnal sleep”. Typically, one orifice was for common use and the rest for the circumstantial escape. According to their form, their localization in the ground, and the number and location of orifices, sleeping dens were classified into four types, of which type A was the most common. The results also indicate a greater concentration of sleeping dens in temporary flooded gallery forest.

  5. Review of Critical Issues in the Pathogenesis of Atopic Dermatitis.

    Science.gov (United States)

    Irvine, Alan D; Eichenfield, Lawrence F; Friedlander, Sheila F; Simpson, Eric L

    2016-06-01

    About a decade age, loss-of-function mutations in the filaggrin molecule were first implicated in the pathogenesis of ichthyosis vulgaris and, subsequently, of atopic dermatitis and other atopic diseases. Since then, intensive study of the role of filaggrin null mutations have led to other milestones in understanding the pathologic pathways in these diseases, including the initiation, maintenance, and promotion of the disease processes. The result has been new and emerging clinical and pharmacologic strategies for early identification of and intervention in atopic diseases. Semin Cutan Med Surg 35(supp5):S89-S91. 2016 published by Frontline Medical Communications.

  6. [The pathogenesis of periodontal disease: a paradigm shift].

    Science.gov (United States)

    Ekstein, J; Shapira, L; Van Dyke, T E

    2010-07-01

    Periodontitis is a family of related diseases that differ in etiology, natural history, disease progression and response to therapy, but have a common underlying chain of events, thatareinfluenced by disease modifiers. The clinical manifestations observed are a result of the complex interplay of these factors. The pathogenesis of human periodontitis was placed on a rational footing for the first time by Page & Schroeder in 1976 and the general principles and the overall conclusions reached in that article are still largely acceptable today. Still, an enormous amount has been learned about all aspects of human periodontitis, including its pathogenesis, since 1976. A critical evaluation of the literature regarding the complex relationship between the microbial factor, the host factor and the occurrence of a disease, might be leading us over a surge of a paradigm shift in our understanding the pathogenesis of the disease. It is well acknowledged that while the etiology of periodontitis is bacterial, the pathogenesis is inflammatory. The understanding of regulation of inflammation in periodontitis is far from complete; however, as the understanding of periodontal inflammation increases, the current understanding of the microbiology of periodontitis becomes less clear. While we think we know that bacteria initiate the disease, the role of specific bacteria is still unknown. The current knowledge of the microbiology of periodontitis is based on large cross-sectional and association studies. Periodontitis is seen as the direct consequence of bacterial invasion and is regarded as an infectious disease. It is however, not possible to draw cause and- effect inferences from these studies. One might state that the inflammation precedes the overgrowth of the bacteria. In this scenario, the initiator of the disease might be early, gram-positive colonizers that elicit a profound inflammatory response in the susceptible host. The implication of that paradigm shift outlined above

  7. Molecular Pathogenesis and Current Therapy in Intrahepatic Cholangiocarcinoma

    DEFF Research Database (Denmark)

    Høgdall, Dan Taksony Solyom; O'Rourke, Colm J; Taranta, Andrzej

    2016-01-01

    Intrahepatic cholangiocarcinoma (iCCA) comprises one of the most rapidly evolving cancer types. An underlying chronic inflammatory liver disease that precedes liver cancer development for several decades and creates a pro-oncogenic microenvironment frequently impairs progress in therapeutic...... approaches. Depending on the cellular target of malignant transformation, a large spectrum of molecular and morphological patterns is observed. As such, it is crucial to advance our existing understanding of the molecular pathogenesis of iCCA, particularly its genomic heterogeneity, to improve current...

  8. Morbillivirus Experimental Animal Models: Measles Virus Pathogenesis Insights from Canine Distemper Virus.

    Science.gov (United States)

    da Fontoura Budaszewski, Renata; von Messling, Veronika

    2016-10-11

    Morbilliviruses share considerable structural and functional similarities. Even though disease severity varies among the respective host species, the underlying pathogenesis and the clinical signs are comparable. Thus, insights gained with one morbillivirus often apply to the other members of the genus. Since the Canine distemper virus (CDV) causes severe and often lethal disease in dogs and ferrets, it is an attractive model to characterize morbillivirus pathogenesis mechanisms and to evaluate the efficacy of new prophylactic and therapeutic approaches. This review compares the cellular tropism, pathogenesis, mechanisms of persistence and immunosuppression of the Measles virus (MeV) and CDV. It then summarizes the contributions made by studies on the CDV in dogs and ferrets to our understanding of MeV pathogenesis and to vaccine and drugs development.

  9. Morbillivirus Experimental Animal Models: Measles Virus Pathogenesis Insights from Canine Distemper Virus

    Directory of Open Access Journals (Sweden)

    Renata da Fontoura Budaszewski

    2016-10-01

    Full Text Available Morbilliviruses share considerable structural and functional similarities. Even though disease severity varies among the respective host species, the underlying pathogenesis and the clinical signs are comparable. Thus, insights gained with one morbillivirus often apply to the other members of the genus. Since the Canine distemper virus (CDV causes severe and often lethal disease in dogs and ferrets, it is an attractive model to characterize morbillivirus pathogenesis mechanisms and to evaluate the efficacy of new prophylactic and therapeutic approaches. This review compares the cellular tropism, pathogenesis, mechanisms of persistence and immunosuppression of the Measles virus (MeV and CDV. It then summarizes the contributions made by studies on the CDV in dogs and ferrets to our understanding of MeV pathogenesis and to vaccine and drugs development.

  10. The origin of art according to Karl von den Steinen

    Directory of Open Access Journals (Sweden)

    Pierre Déléage

    2015-06-01

    Full Text Available Based on a study of the custom, adopted by ethnologists in the early 20th century, of asking Amerindians of Lowland South America to do drawings in pencil in their notebooks, I explore three forgotten fragments of the history of thinking: the intense debates on the origin of ornaments, opposing an evolutionist and a materialist approach at the end of the 19th century; the theories on the origin of figuration, which I show date back to the important work of Karl von den Steinen regarding the populations of central Brazil; and the publications of ethnologists’ portraits drawn by Indians of the lowlands of South America, a little-known tradition of reverse anthropology serving as a counterpoint to the study of the reception of Amerindian art in Western ethnological literature.

  11. Dens invaginatus in an impacted mesiodens: a morphological study.

    Science.gov (United States)

    Cantín, M; Fonseca, G M

    2013-01-01

    Dens invaginatus (DI) is a dental anomaly originated from invagination of the enamel organ into the dental papilla, during odontogenesis. DI may be associated with other abnormalities such as dysmorphic mesiodens, and this unusual condition may be detected by chance on the conventional radiography. However, the three-dimensional nature and the exact morphological patterns of DI are impossible to appreciate from this method. We present a morphological study of impacted mesiodens in a 9-year-old girl, which the three coronal invaginations were detected only by Cone-Beam Computed Tomography (CBCT) in the pre-surgical examination. CBCT, radiographic and microscopic reproductions allow transfer of images to facilitate cooperation of working groups, examination as well as for teaching purposes.

  12. Dens invaginatus in a geminated maxillary lateral incisor

    Science.gov (United States)

    Pallivathukal, Renjith George; Misra, Alok; Nagraj, Sumanth Kumbargere; Donald, Preethy Mary

    2015-01-01

    Dens invaginatus (DI) and gemination are two developmental abnormalities that are well reported in the dental literature, but their coexistence in a single tooth is rare. Such situations worsen the risk factors associated with these anomalies, and the treatment plan should be customised as they possess altered morphology and anatomy. A 19-year-old girl came for evaluation of a cracked tooth in the front region of the upper jaw. The tooth showed clinical features of gemination and radiographic features of DI, and was diagnosed as DI in geminated maxillary lateral incisor. The differential diagnoses based on clinical appearance without radiographic investigation may warrant the treatment approach if these two abnormalities coexist in a single tooth. The report also highlights the importance of three-dimensional imaging in diagnosis and treatment planning of teeth with altered pulp canal anatomy. There are few reported cases in the literature detailing the treatment options for these two anomalies occurring in the same tooth. PMID:26002668

  13. Die polnischen Bücher (Bücherbestände in den Bibliotheken Roms. Eine Auswahl

    Directory of Open Access Journals (Sweden)

    Ligia ALeksandra Henczel-Wróblewska

    2017-11-01

    Full Text Available Die italienisch-polnischen Beziehungen haben eine lange Geschichte hinter sich. Seit dem Mittelalter, in dem die polnischen Scholaren ihre Ausbildung an den italienischen Universitäten genießen konnten, dominierte darin der wissenschaftliche und bildende Charakter. In den folgenden Jahrhunderten wurde der gegenseitige Kontakt um die künstlerische Ebene erweitert, zumal die polnischen Künstler nach Italien reisten, um bei den besten Meistern ihre Fertigkeiten zu vervollkommnen. Seit dem Ende des 18. bis zur Mitte des 19. Jahrhunderts kam zu den bereits bestehenden, tradierten italienischpolnischen Beziehungen im Bereich der Wissenschaft und Kultur der militärische und der sozialpolitische Aspekt hinzu, und mit der Zeit auch der wirtschaftliche. Auf dem italienischen Boden beteiligten sich die Polen zunächst an den Unabhängigkeitskämpfen, die mit der Vereinigung Italiens (die Risorgimento-Zeit endeten, und nachher an den Waffeninterventionen während der zwei Weltkriege. Seit der Mitte des 20. Jahrhunderts kehrte man zum früheren beiderseitigen Kontakt auf verschiedenen Ebenen zurück.In jeder dieser Zeitspannen wurde die polnische Anwesenheit in Italien in den schriftlichen, ikonografischen, künstlerischen Quellen belegt. Die meisten davon bewährten sich in den Archiven und Bibliotheken Roms, dem Zentrum der europäischen Wissenschaft, Kultur und Christenheit. Erst im 20. Jahrhundert, seit der Entstehung der ersten wissenschaftlichen polnischen Institutionen in Rom und dank der breiten Zusammenarbeit war es möglich, die Polonica, die sich in den römischen Bibliotheken, Archiven, Kulturinstitutionen und Privatbeständen befinden, offiziell zu registrieren, bearbeiten und ordnen. Die schriftlichen Denkmäler aus den vergangenen Jahrhunderten weisen auf eine breite gegenseitige Beziehung sowohl im Bereich des sacrum als auch des profanum hin. Dieses gemeinsame historische Gedächtniserbe zeugt von einer langen Zugehörigkeit Polens zur

  14. An Unusual Type II Dens Invaginatus with Calcified Canals in a Maxillary Lateral Incisor - A Case Report.

    Science.gov (United States)

    Subbiya, Arunajatesan; Geethapriya, Nagarajan; Pradeepkumar, Angambakam Rajasekaran; Vivekanandhan, Paramasivam

    2013-09-01

    Dens invaginatus is a developmental malformation resulting from the invagination of enamel organ into the dental papilla. Management of dens invaginatus is an endodontic challenge. Presence of calcified canals in dens invaginatus makes it even more complicated. Modification of the treatment plan is required to treat such cases. This case report deals with the management of a Type II Dens Invaginatus in a lateral incisor with calcified canals.

  15. An Unusual Type II Dens Invaginatus with Calcified Canals in a Maxillary Lateral Incisor – A Case Report

    OpenAIRE

    Subbiya, Arunajatesan; Geethapriya, Nagarajan; Pradeepkumar, Angambakam Rajasekaran; Vivekanandhan, Paramasivam

    2013-01-01

    Dens invaginatus is a developmental malformation resulting from the invagination of enamel organ into the dental papilla. Management of dens invaginatus is an endodontic challenge. Presence of calcified canals in dens invaginatus makes it even more complicated. Modification of the treatment plan is required to treat such cases. This case report deals with the management of a Type II Dens Invaginatus in a lateral incisor with calcified canals.

  16. Den enes död, den andres bröd : En fallstudie i Fonus kriskommunikation

    OpenAIRE

    Orest Flavet, Sebastian

    2014-01-01

    Denna studie undersöker hur begravningsbyrån Fonus valde att bemöta en kritisk artikel, publicerad i Aftonbladet, med ett pressmeddelande som lades upp på den egna hemsidan. Uppsatsen undersöker först vilka retoriska verktyg som har använts i skapandet av detta meddelande, och sett från Benoits teori om Image Repair, vilka strategier som använts och hur användningen av dessa har sett ut. Därefter söker studien att praktiskt undersöka detta budskap genom att låta en utvald grupp respondenter t...

  17. Rumänische Komponisten zwischen den "gemäßigten", den "radikalen" Moderne und der Postmoderne

    Directory of Open Access Journals (Sweden)

    Sandu-Dediu Valentina

    2006-01-01

    Full Text Available (nemački Debatten um die Begriffe Tradition, Moderne, Avantgarde und Postmoderne, wie sie in der europäischen Exegese erscheinen, sind im rumänischen Raum nicht minder gegenwärtig. Die gemäßigte und die radikale Moderne sowie die Postmoderne werden in diesem Aufsatz auf ihre Verbindung zur Ideologie der rumänischen Musik untersucht. Zum einen werden zwei Richtungen derselben Generation beleuchtet: die "Moderierten" (P. Bentoiu W.G. Berger und die "Radikalen" (Şt. Niculescu, A. Stroe, A. Vieru, T. Olah M. Marbe, D. Constantinescu. Zum anderen wird nachvollzogen, wie sich einige "Radikale" auf den "postmodernen" Weg begeben. Diese Kategorien sind selbstverständlich vom ideologischen Kontext des kommunistischen Rumänien geprägt.

  18. Bordetella pertussis pathogenesis: current and future challenges

    Science.gov (United States)

    Melvin, Jeffrey A.; Scheller, Erich V.; Miller, Jeff F.; Cotter, Peggy A.

    2014-01-01

    Pertussis, or whooping cough, has recently reemerged as a major public health threat despite high levels of vaccination against the etiological agent, Bordetella pertussis. In this Review, we describe the pathogenesis of this disease, with a focus on recent mechanistic insights into virulence factor function. We also discuss the changing epidemiology of pertussis and the challenges of vaccine development. Despite decades of research, many aspects of B. pertussis physiology and pathogenesis remain poorly understood. We highlight knowledge gaps that must be addressed to develop improved vaccines and therapeutic strategies. PMID:24608338

  19. Stromwen.de - how to save electricity in the deregulated market. With competition 'Get the energy robbers'; Stromwen.de - jetzt kraeftig sparen. Mit Gewinnspiel 'Den Energieraeubern auf der Spur'

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    Not so difficult to understand power generation by this brochure from the following energy sources: hydropower, wind power, solar energy, geothermal heat and biomass.(GL) [German] In leicht verstaendlicher Weise werden die Stromerzeugung aus den folgenden Energiequellen beschrieben: Wasserkraft, Windkraft, Sonnenenergie, Erdwaerme und Biomasse.(GL)

  20. Modifier genes: Moving from pathogenesis to therapy.

    Science.gov (United States)

    McCabe, Edward R B

    2017-09-01

    This commentary will focus on how we can use our knowledge about the complexity of human disease and its pathogenesis to identify novel approaches to therapy. We know that even for single gene Mendelian disorders, patients with identical mutations often have different presentations and outcomes. This lack of genotype-phenotype correlation led us and others to examine the roles of modifier genes in the context of biological networks. These investigations have utilized vertebrate and invertebrate model organisms. Since one of the goals of research on modifier genes and networks is to identify novel therapeutic targets, the challenges to patient access and compliance because of the high costs of medications for rare genetic diseases must be recognized. A recent article explored protective modifiers, including plastin 3 (PLS3) and coronin 1C (CORO1C), in spinal muscular atrophy (SMA). SMA is an autosomal recessive deficit of survival motor neuron protein (SMN) caused by mutations in SMN1. However, the severity of SMA is determined primarily by the number of SMN2 copies, and this results in significant phenotypic variability. PLS3 was upregulated in siblings who were asymptomatic compared with those who had SMA2 or SMA3, but identical homozygous SMN1 deletions and equal numbers of SMN2 copies. CORO1C was identified by interrogation of the PLS3 interactome. Overexpression of these proteins rescued endocytosis in SMA models. In addition, antisense RNA for upregulation of SMN2 protein expression is being developed as another way of modifying the SMA phenotype. These investigations suggest the practical application of protective modifiers to rescue SMA phenotypes. Other examples of the potential therapeutic value of novel protective modifiers will be discussed, including in Duchenne muscular dystrophy and glycerol kinase deficiency. This work shows that while we live in an exciting era of genomic sequencing, a functional understanding of biology, the impact of its

  1. Hibernacula and summer den sites of pine snakes (Pituophis melanoleucus) in the New Jersey pine barrens

    Science.gov (United States)

    Burger, J.; Zappalorti, R.T.; Gochfeld, M.; Boarman, W.I.; Caffrey, M.; Doig, V.; Garber, S.D.; Lauro, B.; Mikovsky, M.; Safina, C.; Saliva, Jorge

    1988-01-01

    We examined eight summer dens (used only in summer) and seven hibernacula (occupied both in winter and summer) of the snake Pituophis melanoleucus in the New Jersey Pine Barrens, comparing above ground characteristics of hibernacula and summer dens with characteristics at nearby random points. Temperatures at the soil surface and at 10 cm depth were significantly warmer, and there was less leaf cover around the random points compared to the entrances of the hibernacula and summer dens. Hibernacula had significantly more vegetation cover within 5 m, more leaf cover over the burrow entrance, and were closer to trees than were summer dens. Most hibernacula and summer dens were beside old fallen logs (73%), the entrance tunnels following decaying roots into the soil. Excavation of the hibernacula and summer dens indicated that most hibernacula appeared to be dug by the snakes and had an average of eight side chambers and 642 cm of tunnels, compared to less than one side chamber and 122 cm of tunnels for summer dens. Except for hatchlings, most snakes in hibernacula were located in individual chambers off the main tunnel; all snakes were at depths of 50-111 cm (X̄ = 79 cm). Pine snakes may select optimum hibernation sites which reduce winter mortality.

  2. Grizzly bear denning and potential conflict areas in the Greater Yellowstone Ecosystem

    Science.gov (United States)

    Podruzny, Shannon; Cherry, Steve; Schwartz, Charles C.; Landenburger, Lisa

    2002-01-01

    Increasing winter use of steep, high-elevation terrain by backcountry recreationists has elevated concern about disturbance of denning grizzly bears (Ursus arctos) in the Greater Yellowstone Ecosystem (GYE). To help identify areas where such conflicts might occur, we developed a spatially explicit model to predict potential denning areas in the GYE. Using a scan area of 630 m around each location, we assigned site attributes to 344 den locations of radio-trackedg rizzly bears from 1975-99. Attributesi dentified as predictorsf or the analysis included elevation, slope, an index of solar radiation, and forest cover. We used the Mahalanobis distance statistic to model the similarity between sites used by denning bears and each cell in the data layers. We used the final Mahalanobis distance model to produce maps of the study area. Potential denning habitat, based upon the model, is abundantw ithin the GYE. Ourr esultsc an be used by land managementa gencies to identifyp otentialc onflict sites and minimize effects of regulated activities on denning grizzly bears. We illustrate how the Gallatin National Forest (GNF) used the model to examine the overlap between potential snowmobile use areas and potential denning habitat as part of a Biological Assessment submitted to the U.S. Fish and Wildlife Service.

  3. Radiographic Study of the Prevalence of Dens Invaginatus in a Sample Set of Turkish Dental Patients

    Directory of Open Access Journals (Sweden)

    Hakan Çolak

    2012-01-01

    Full Text Available Aim: The aim of this study was to determine the prevalence of dens invaginatus in a sample of Turkish dental patients. Materials and Methods: The sample included 6, 912 panoramic radiographs from different Turkish dental patients. The ages of the patients ranged from 18 to 50 years. A tooth was considered having dens invaginatus if an infolding of a radiopaque ribbon-like structure equal in density to enamel was seen extending from the cingulum into the root canal. Maxillary and mandibular teeth were evaluated on panoramic radiographs to determine the type of dens invaginatus using Oehlers′ classification. Results: The overall incidence of patients with dens invaginatus was 0.17%. Dens invaginatus were detected in 15 teeth of a total of 192 150 teeth to give a tooth prevalence of 0.008%. Maxillary lateral incisors were most commonly affected teeth in the mouth (80% of cases, followed by maxillary canine teeth (20% of cases. The bilateral incidence of a symmetrical distribution was 25%. Conclusion: The occurrence of dens invaginatus among this Turkish population was rare. Attention should be paid to the presence of dens invaginatus and the treatment problems associated with it.

  4. Radiographic study of the prevalence of dens invaginatus in a sample set of Turkish dental patients.

    Science.gov (United States)

    Colak, Hakan; Tan, Enes; Aylıkçı, Bahadır Uğur; Uzgur, Recep; Turkal, Mustafa; Hamidi, Mehmet Mustafa

    2012-01-01

    The aim of this study was to determine the prevalence of dens invaginatus in a sample of Turkish dental patients. The sample included 6, 912 panoramic radiographs from different Turkish dental patients. The ages of the patients ranged from 18 to 50 years. A tooth was considered having dens invaginatus if an infolding of a radiopaque ribbon-like structure equal in density to enamel was seen extending from the cingulum into the root canal. Maxillary and mandibular teeth were evaluated on panoramic radiographs to determine the type of dens invaginatus using Oehlers' classification. The overall incidence of patients with dens invaginatus was 0.17%. Dens invaginatus were detected in 15 teeth of a total of 192 150 teeth to give a tooth prevalence of 0.008%. Maxillary lateral incisors were most commonly affected teeth in the mouth (80% of cases), followed by maxillary canine teeth (20% of cases). The bilateral incidence of a symmetrical distribution was 25%. The occurrence of dens invaginatus among this Turkish population was rare. Attention should be paid to the presence of dens invaginatus and the treatment problems associated with it.

  5. Assessment of the prevalence and characteristics of dens invaginatus in a sample of Turkish Anatolian population.

    Science.gov (United States)

    Cakici, Fatih; Celikoglu, Mevlut; Arslan, Hakan; Topcuoglu, Huseyin-Sinan; Erdogan, Aziz-Sahin

    2010-11-01

    The objective of this study was to assess the prevalence and characteristics of dens invaginatus in anterior teeth and to classify the type of dens invaginatus in a sample of Turkish Anatolian population. A retrospective study was performed using full-mouth periapical and panoramic radiographs of 1012 patients. Maxillary and mandibular anterior teeth were evaluated for the presence and characteristics of dens invaginatus. Statistical evaluation of the presence of dens invaginatus related to gender was performed by the Pearson chi-squared test. Dens invaginatus was observed in 13 out of 1012 subjects and in only maxillary lateral incisors. There were no periapical lesions in teeth with types I and II, whereas both of the subjects with type III had apical periodontitis at the time of referral. Males and females were equally affected by dens invaginatus (P=0.98). The anomaly was detected in only maxillary lateral incisors with no gender difference and the most commonly observed type of dens invaginatus was type I (81.25%).

  6. Molecular pathogenesis of long QT syndrome type 1

    Directory of Open Access Journals (Sweden)

    Jie Wu, PhD

    2016-10-01

    Full Text Available Long QT syndrome type 1 (LQT1 is a subtype of a congenital cardiac syndrome caused by mutation in the KCNQ1 gene, which encodes the α-subunit of the slow component of delayed rectifier K+ current (IKs channel. Arrhythmias in LQT1 are characterized by prolongation of the QT interval on ECG, as well as the occurrence of life-threatening cardiac events, frequently triggered by adrenergic stimuli (e.g., physical or emotional stress. During the past two decades, much advancement has been made in understanding the molecular pathogenesis underlying LQT1. Uncovering the genotype-phenotype correlations in LQT1 is of clinical importance to better understand the gene-specific differences that may influence the propensity for developing life-threatening arrhythmias under specific conditions. Elucidation of these mechanisms will also help to improve the diagnosis and management of this cardiac disorder based on gene-specific considerations. This review describes the current medical consensus and recent developments regarding the molecular pathogenesis of LQT1 and provides a novel insight into the adrenergic regulation of this disease.

  7. Neutralizing Antibodies and Pathogenesis of Hepatitis C Virus Infection

    Directory of Open Access Journals (Sweden)

    Françoise Stoll-Keller

    2012-10-01

    Full Text Available Hepatitis C virus (HCV infection is a major cause of chronic liver disease worldwide. The interplay between the virus and host innate and adaptive immune responses determines the outcome of infection. There is increasing evidence that host neutralizing responses play a relevant role in the resulting pathogenesis. Furthermore, viral evasion from host neutralizing antibodies has been revealed to be an important contributor in leading both to viral persistence in acute liver graft infection following liver transplantation, and to chronic viral infection. The development of novel model systems to study HCV entry and neutralization has allowed a detailed understanding of the molecular mechanisms of virus-host interactions during antibody-mediated neutralization. The understanding of these mechanisms will ultimately contribute to the development of novel antiviral preventive strategies for liver graft infection and an urgently needed vaccine. This review summarizes recent concepts of the role of neutralizing antibodies in viral clearance and protection, and highlights consequences of viral escape from neutralizing antibodies in the pathogenesis of HCV infection.

  8. Pathogenesis of helicobacter pylori infection involves interaction ...

    African Journals Online (AJOL)

    It is now clear that both bacterial virulence factors and host susceptibility play key roles in disease pathogenesis. The nature and levels of these interactions between these major factors has been found to determine the spectrum of clinical outcomes of the infection with this important bacterium. Virulence factors include the ...

  9. Pathogenesis of nosocomial infections with Enterococcus faecalis

    NARCIS (Netherlands)

    Waar, Karola

    2004-01-01

    In this thesis, we analyzed the role of the different virulence factors of E. faecalis known in literature in the pathogenesis of infections. We investigated the prevalence of virulence factors in E. faecalis isolates from different hosts as well as their role in biomaterial related infections. The

  10. Frontoethmoidal encephaloceles, a study of their pathogenesis

    NARCIS (Netherlands)

    Hoving, Eelco; Vermeij-Keers, C

    1997-01-01

    A prospective clinical study of 30 patients with frontoethmoidal encephaloceles was performed in order to find support for a proposed theory concerning its pathogenesis, based on a previously performed embryological study and relevant findings in the literature. According to this proposed theory the

  11. Fungal Plant Pathogenesis Mediated by Effectors

    NARCIS (Netherlands)

    Wit, de P.J.G.M.; Testa, A.; Oliver, R.

    2016-01-01

    The interactions between fungi and plants encompass a spectrum of ecologies ranging from saprotrophy (growth on dead plant material) through pathogenesis (growth of the fungus accompanied by disease on the plant) to symbiosis (growth of the fungus with growth enhancement of the plant). We consider

  12. Pathogenesis of bovine spongiform encephalopathy in sheep

    NARCIS (Netherlands)

    Keulen, van L.J.M.; Vromans, M.E.W.; Dolstra, C.H.; Bossers, A.; Zijderveld, van F.G.

    2008-01-01

    The pathogenesis of bovine spongiform encephalopathy (BSE) in sheep was studied by immunohistochemical detection of scrapie-associated prion protein (PrPSc) in the gastrointestinal, lymphoid and neural tissues following oral inoculation with BSE brain homogenate. First accumulation of PrPSc was

  13. [Purulent corneal ulcers: etiology, pathogenesis, classification].

    Science.gov (United States)

    Kasparova, Evg A; Kasparova, Evg A

    2015-01-01

    Advanced purulent corneal ulcer, as well as abscess, is a serious vision-threatening condition notable for its fulminant course and possible loss of the eye due to endophthalmitis. Its leading causes, pathogenesis, and classifications are described and analyzed in this paper.

  14. Inducing G2/M Cell Cycle Arrest and Apoptosis through Generation Reactive Oxygen Species (ROS)-Mediated Mitochondria Pathway in HT-29 Cells by Dentatin (DEN) and Dentatin Incorporated in Hydroxypropyl-β-Cyclodextrin (DEN-HPβCD).

    Science.gov (United States)

    Ashwaq, Al-Abboodi Shakir; Al-Qubaisi, Mothanna Sadiq; Rasedee, Abdullah; Abdul, Ahmad Bustamam; Taufiq-Yap, Yun Hin; Yeap, Swee Keong

    2016-10-18

    Dentatin (DEN), purified from the roots of Clausena excavata Burm f., has poor aqueous solubility that reduces its therapeutic application. The aim of this study was to assess the effects of DEN-HPβCD (hydroxypropyl-β-cyclodextrin) complex as an anticancer agent in HT29 cancer cell line and compare with a crystal DEN in dimethyl sulfoxide (DMSO). The exposure of the cancer cells to DEN or DEN-HPβCD complex leads to cell growth inhibition as determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. To analyze the mechanism, in which DEN or DEN-HPβCD complex causes the death in human colon HT29 cancer cells, was evaluated by the enzyme-linked immunosorbent assay (ELIZA)-based assays for caspase-3, 8, 9, and reactive oxygen species (ROS). The findings showed that an anti-proliferative effect of DEN or DEN-HPβCD complex were via cell cycle arrest at the G2/M phase and eventually induced apoptosis through both mitochondrial and extrinsic pathways. The down-regulation of poly(ADP-ribose) polymerase (PARP) which leaded to apoptosis upon treatment, was investigated by Western-blotting. Hence, complexation between DEN and HPβCD did not diminish or eliminate the effective properties of DEN as anticancer agent. Therefore, it would be possible to resolve the conventional and current issues associated with the development and commercialization of antineoplastic agents in the future.

  15. Conservative Management of Type III Dens in Dente Using Cone Beam Computed Tomography

    Directory of Open Access Journals (Sweden)

    K Pradeep

    2012-01-01

    Full Text Available Dens in dente, also known as dens invaginatus, dilated composite odontoma, or deep foramen caecum, is a developmental malformation that usually affects maxillary incisor teeth, particularly lateral incisors. It may occur in teeth anywhere within the jaws, other locations are comparatively rare. It can occur within both the crown and the root, although crown invaginations are more common. The use of cone beam computed tomography (CBCT is very helpful in endodontic diagnosis of complex anatomic variations. In this case we demonstrate the use of CBCT in the evaluation and endodontic management of a Type III dens in dente (Oehler′s Type III.

  16. Den försvunna vaginan : Fetischer och gestaltning i transsexuell amatörinternetpornografi

    OpenAIRE

    Nino Cortés, Daniel M.; Oscarsson, Carolina

    2015-01-01

    Denna uppsats undersöker hur transsexuella individer gestaltas på den amatörinternetpornaografiska webbsidan XVIDEOS - den största internetpornografiska webbsidan. Vi har tittat på hur XVIDEOS som webbsida är med i denna gestaltning och process och hur XVIDEOS och dess innehåll återger en bild av vad den transsexuella kroppen - och sexualiteten förväntas vara. Det effektivaste sättet att föra denna undersökning på, är i vårt fall att analysera mainstream amatörinternetpornografi med transsexu...

  17. Dens invagination: A review of literature and report of two cases

    Science.gov (United States)

    Thakur, Seema; Thakur, Narbir S.; Bramta, Manmohan; Gupta, Mohit

    2014-01-01

    Dens invaginatus occurs as a result of the invagination of the enamel organ. These cases may present difficulties with respect to its diagnosis and treatment because of canal morphology. It frequently leads to caries, pulpal, and periodontal involvement with necrosis and loss of attachment. The knowledge of classification and anatomical variations of teeth with dens invaginatus are of great importance for correct treatment. This article presents two case reports of two different types of dens invaginatus along with profound review of the literature regarding etiology, epidemiology, and histology. It discusses clinical appearance and diagnosis, and it provides guidelines for decision-making and treatment of invaginated teeth. PMID:24678234

  18. Type III Dens Invaginatus with an Associated Cyst: A Case Report and Literature Review.

    Science.gov (United States)

    Meghana, S M; Thejokrishna, P

    2011-01-01

    Dens invaginatus (dens in dente) is a rare malformation with a widely varied morphology. An unusual presentation of a type III dens invaginatus affecting a conical shaped permanent lateral incisor in an 8-year-old female patient is reported. The presence of a pulp stone and a periapical radiolucency further added onto the complexity of the case. The etiology, pathophysiology, association with other dental anomalies as well as the challenges in management of this anomaly are discussed. An extensive literature review is also presented.

  19. Conventional Treatment of Maxillary Incisor Type III Dens Invaginatus with Periapical Lesion: A Case Report.

    Science.gov (United States)

    Borges, Alvaro Henrique; Semenoff Segundo, Alex; Nadalin, Michele Regina; Pedro, Fábio Luís Miranda; da Cruz Filho, Antônio Miranda; Sousa-Neto, Manoel Damião

    2011-01-01

    Dens invaginatus is a developmental dental anomaly clinically characterized by a palatine furrow that can be limited to the coronal pulp or may extend to the radicular apex. The purpose of this paper was to present a clinical case of type III dens invaginatus, identified on the maxillary right central incisor in anterior periapical radiographs, in which the tooth was submitted to conventional endodontic treatment. The results obtained after five years of clinical and radiographic followup demonstrated that conventional endodontic treatment is a clinically viable alternative in cases of type III dens invaginatus.

  20. Schulze and Brand type a-IV dens invaginatus with radicular cyst: A rare case report

    Directory of Open Access Journals (Sweden)

    Rachita Chengappa

    2015-01-01

    Full Text Available Though a clinical examination may reveal a deep fissure or pit on the surface of an anterior tooth, radiographic examination is a more accurate approach to diagnose an invagination. Dens invaginatus is one of the common dental deformities, but the defect involving the root and its association with radicular cyst is still very uncommon. The objective of this case presentation is to report a case of radicular dens in dente, which is a rare dental anomaly. This case report shows that dens invaginatus with an open apex and a radicular cyst can be treated successfully using currently available materials.

  1. Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis

    DEFF Research Database (Denmark)

    Thorsteinsdottir, Sigrun; Gudjonsson, Thorkell; Nielsen, Ole Haagen

    2011-01-01

    One of the most serious complications of ulcerative colitis is the development of colorectal cancer. Screening patients with ulcerative colitis by standard histological examination of random intestinal biopsy samples might be inefficient as a method of cancer surveillance. This Review focuses...... on the current understanding of the pathogenesis of ulcerative colitis-associated colorectal cancer and how this knowledge can be transferred into patient management to assist clinicians and pathologists in identifying patients with ulcerative colitis who have an increased risk of colorectal cancer. Inflammation....... Although progress has been made in the understanding of inflammation-driven carcinogenesis, markers based on these findings possess insufficient sensitivity or specificity to be usable as reliable biomarkers for risk of colorectal cancer development in patients with ulcerative colitis. However, screening...

  2. Mellem storpolitik og værkstedsgulv. Den danske arbejder - før, under og efter Den kolde krig

    DEFF Research Database (Denmark)

    Nielsen, Niels Jul

    2004-01-01

    for den løn­arbejdende del af befolkningen og dens politiske repræsentanter? Og hvilken rolle er den jævne arbejder blevet tildelt i denne historie? Gennem et nærbillede af Danmarks mest karakteristiske - og politisk iscenesat­te - virksomhed, Burmeister & Wain, undersøges sammenhængen mellem skiften......, 1950ernes og -60ernes koldkrigs­klima med benhårde fronter mellem kommuni­ster og social­demokrater, radikali­seringen omkring 1970, til østblokkens sam­menbrud og de sidste årtiers udvikling, der har betydet, at man i dag ikke længere taler om 'arbejdere'....

  3. Om den uformelle (misbrug af medier i det formelle uddannelsessystem

    Directory of Open Access Journals (Sweden)

    Michael Paulsen

    2008-09-01

    Full Text Available En kombination af uddannelsesforskning og medieforskning anvendes til at forstå gymnasieelevers brug af nye digitale medier. På baggrund af elev- og lærerinterview fremlægger forfatterne en tolkning af mediebrugens betydning for de formelle læreprocesser. Artiklen kommer frem til, at medierne afleder elevernes opmærksomhed og fører til afhængighedsproblemer. Forfatterne fremlægger en tolkning af, hvordan eleverne afledes, og hvad de afledes til. Igennem denne tolkning kommer artiklen frem til, at medier som Messenger ikke blot afleder opmærksomhed, men også dekonstruerer forskellen mellem formelle og uformelle læreprocesser. I modsætning til, hvad eleverne og lærerne selv fortæller, indikerer tolkningen, at der finder en læring sted via elevernes dekonstruerende brug af de nye medier, men at lærerne ekskluderes fra de processer, hvorigennem læringen initieres. Artiklen konkluderer, at der bør udvikles en mediedidaktik, der dels afhjælper elevers afhængighedsproblemer, dels giver lærerne styrke til at spille en aktiv rolle ift. den sociale interaktion og læring, som de nye medier muliggør.

  4. Om den uformelle (misbrug af medier i det formelle uddannelsessystem

    Directory of Open Access Journals (Sweden)

    Michael Paulsen

    2009-06-01

    Full Text Available En kombination af uddannelsesforskning og medieforskning anvendes til at forstå gymnasieelevers brug af nye digitale medier. På baggrund af elev- og lærerinterview fremlægger forfatterne en tolkning af mediebrugens betydning for de formelle læreprocesser. Artiklen kommer frem til, at medierne afleder elevernes opmærksomhed og fører til afhængighedsproblemer. Forfatterne fremlægger en tolkning af, hvordan eleverne afledes, og hvad de afledes til. Igennem denne tolkning kommer artiklen frem til, at medier som Messenger ikke blot afleder opmærksomhed, men også dekonstruerer forskellen mellem formelle og uformelle læreprocesser. I modsætning til, hvad eleverne og lærerne selv fortæller, indikerer tolkningen, at der finder en læring sted via elevernes dekonstruerende brug af de nye medier, men at lærerne ekskluderes fra de processer, hvorigennem læringen initieres. Artiklen konkluderer, at der bør udvikles en mediedidaktik, der dels afhjælper elevers afhængighedsproblemer, dels giver lærerne styrke til at spille en aktiv rolle ift. den sociale interaktion og læring, som de nye medier muliggør.

  5. A realidade da pesquisa no DEN/UFS

    Directory of Open Access Journals (Sweden)

    Delvair de Brito Alves

    1998-12-01

    Full Text Available Esta pesquisa trata do processo de pesquisar no Departamento de Enfermagem e Nutrição da Universidade Federal de Sergipe - DEN/UFS. Ela foi desenvolvida a partir de entrevistas semi estruturadas realizadas com as docentes. Dos materiais obtidos, apresentamos concepções das docentes sobre grupos, linhas e projetos de pesquisa; a produção científica docente e discente; dificuldades e possibilidades relativas à atividade de pesquisar; estratégias que esse Departamento vem utilizando para o desenvolvimento da pesquisa, para a capacitação docente e formação de pesquisadores, além da inserção de estudantes (de graduação e de pós graduação no "mundo científico". Ela conclui pela necessidade de aprofundamento dessa atividade e pela divulgação e aplicação dos seus resultados na prática de enfermagem.

  6. Dens invaginatus in a geminated maxillary lateral incisor.

    Science.gov (United States)

    Pallivathukal, Renjith George; Misra, Alok; Nagraj, Sumanth Kumbargere; Donald, Preethy Mary

    2015-05-22

    Dens invaginatus (DI) and gemination are two developmental abnormalities that are well reported in the dental literature, but their coexistence in a single tooth is rare. Such situations worsen the risk factors associated with these anomalies, and the treatment plan should be customised as they possess altered morphology and anatomy. A 19-year-old girl came for evaluation of a cracked tooth in the front region of the upper jaw. The tooth showed clinical features of gemination and radiographic features of DI, and was diagnosed as DI in geminated maxillary lateral incisor. The differential diagnoses based on clinical appearance without radiographic investigation may warrant the treatment approach if these two abnormalities coexist in a single tooth. The report also highlights the importance of three-dimensional imaging in diagnosis and treatment planning of teeth with altered pulp canal anatomy. There are few reported cases in the literature detailing the treatment options for these two anomalies occurring in the same tooth. 2015 BMJ Publishing Group Ltd.

  7. Understanding delusions

    Directory of Open Access Journals (Sweden)

    Chandra Kiran

    2009-01-01

    Full Text Available Delusion has always been a central topic for psychiatric research with regard to etiology, pathogenesis, diagnosis, treatment, and forensic relevance. The various theories and explanations for delusion formation are reviewed. The etiology, classification and management of delusions are briefly discussed. Recent advances in the field are reviewed.

  8. A study of various histopathological features and their relevance in pathogenesis of psoriasis

    Directory of Open Access Journals (Sweden)

    Nikhil Moorchung

    2013-01-01

    Full Text Available Background: The pathogenesis of psoriasis is still to be fully unraveled. The immunological theory with T cells at the centre of attraction and peripherally acting cytokines are the present favourites among aetiopathological factors. Histopathology of the skin lesions offers a good study model to understand the pathogenesis of this complex disease. Aims: To study the various histopathological parameters of psoriatic lesions, and to establish their correlation with the pathogenesis of the disorder. Materials and Methods: Eighty eight consecutive histopathologically proven cases of psoriasis were included in the study. Eight common histopathological parameters of psoriasis present in these biopsies were assessed and graded. We then statistically analyzed the relationship of the factors with one another and attempted to establish a better understanding of the pathogenesis of disease. Results: Significant correlations were found between degree of epidermal hyperplasia and inflammatory infiltrate, grade of inflammation and pustules of Kogoj, inflammatory infiltrate and grade of capillary proliferation as also between epidermal hyperplasia and the presence of parakeratosis. Conclusion: The study suggests that the immunopathogenesis of psoriasis is predominantly based on the inflammatory response. This is in consonance with other studies which have suggested that psoriasis is primarily a T lymphocyte based disease. Several treatment modalities are now based on this concept and it is hoped that the future treatment modalities will focus on the central role of inflammatory cells in the pathogenesis of this enigmatic disease.

  9. Grote plaatstrouw van kokmeeuwen Larus ridibundus aan een winterkwartier in Den Haag

    NARCIS (Netherlands)

    Spaans, A.L.

    2000-01-01

    Resultaten van onderzoek met kleurringen bij kokmeeuwen rond de Hofvijver in Den Haag in de winterperiodes van begin jaren zestig: aantalsverloop, leeftijdsverhouding, herkomst, terugvangsten, en waarnemingen op de ringplaats en elders. Uit dit onderzoek, en ander onderzoek in Nederlandse en

  10. [Memel als Brücke zu den baltischen Ländern] / Ralph Tuchtenhagen

    Index Scriptorium Estoniae

    Tuchtenhagen, Ralph, 1961-

    2014-01-01

    Arvustus: Memel als Brücke zu den baltischen Ländern. Kulturgeschichte Klaipedas vom Mittelalter bis ins 20. Jahrhundert. (Tagungsberichte der Historischen Kommission für ost- und westpreussische Landesforschung. Bd. 26)

  11. Leo den Store: Prædiken på st. Laurentius' dag

    DEFF Research Database (Denmark)

    Willert, Niels

    1992-01-01

    Oversættelse af prædiken holdt af den kendte pave Leo den store i 400-tallet. Prædikenen forholder sig til Sankt Laurentius og hans martyrdød.Oversættelsen er et bidrag i en samling af prædikener fra oldkirken. Bogen har en indledning ved professor dr.theol. Christian Thodberg.......Oversættelse af prædiken holdt af den kendte pave Leo den store i 400-tallet. Prædikenen forholder sig til Sankt Laurentius og hans martyrdød.Oversættelsen er et bidrag i en samling af prædikener fra oldkirken. Bogen har en indledning ved professor dr.theol. Christian Thodberg....

  12. Kvinden, diakonissen og sygeplejersken i Den danske Diakonissestiftelses etableringsfase 1863-1873

    DEFF Research Database (Denmark)

    Lauritzen, Jette

    2005-01-01

    danske Diakonissestiftelse’ during the establishing phase from 1863 to 1873. The inner factors are deducted from numerous readings and interpretations of publicly available sources which ‘Den danske Diakonissestiftelse’, and its adherents, published. Thereby the intentions, goals, and motives the authors......Summary – The Woman, the Deaconess and the Nurse in the establishing phase of ‘Den danske Diakonissestiftelse’ 1863-1873 The thesis examines how the female role as deaconess and nurse manifested itself in the establishing phase of ‘Den danske Diakonissestiftelse’( The danish Deaconess House) from...... and nurse in the establishing phase of `Den danske Diakonissestiftelse`, from 1863 to 1873, was partially culturally unacceptable and not culturally recognisable for the bourgeoisie. This meant that the deaconesses had to fight on all fronts to gain recognition and the possibility to further the cause...

  13. Kvinden, diakonissen og sygeplejersken i Den danske Diakonissestiftelses etableringsfase 1863-1873

    DEFF Research Database (Denmark)

    Lauritzen, Jette

    danske Diakonissestiftelse’ during the establishing phase from 1863 to 1873. The inner factors are deducted from numerous readings and interpretations of publicly available sources which ‘Den danske Diakonissestiftelse’, and its adherents, published. Thereby the intentions, goals, and motives the authors......Summary – The Woman, the Deaconess and the Nurse in the establishing phase of ‘Den danske Diakonissestiftelse’ 1863-1873 The thesis examines how the female role as deaconess and nurse manifested itself in the establishing phase of ‘Den danske Diakonissestiftelse’( The danish Deaconess House) from...... and nurse in the establishing phase of `Den danske Diakonissestiftelse`, from 1863 to 1873, was partially culturally unacceptable and not culturally recognisable for the bourgeoisie. This meant that the deaconesses had to fight on all fronts to gain recognition and the possibility to further the cause...

  14. GMO-afgrøder ikke den eneste løsning

    DEFF Research Database (Denmark)

    Jacobsen, Niels; Jacobsen, Sven-Erik; Sørensen, Marten

    2010-01-01

    Er GMO-afgrøder den optimale løsning på klodens fremtidige plantebaserede fødevareproduktion? Findes der alternativer? Det er der to meget klare svar på:GMOafgrøderer ikke den eneste løsning, og ja, der findes mange og langt mere attraktive, bæredygtige løsninger......Er GMO-afgrøder den optimale løsning på klodens fremtidige plantebaserede fødevareproduktion? Findes der alternativer? Det er der to meget klare svar på:GMOafgrøderer ikke den eneste løsning, og ja, der findes mange og langt mere attraktive, bæredygtige løsninger...

  15. Rare association of dens invaginatus with impacted mesiodens – A case report

    Science.gov (United States)

    Patil, Prashant B.; Chaudhari, Smitha G.; Goel, Ankit; Agarwal, Pooja

    2012-01-01

    Mesiodens is a supernumerary tooth occupying the position in the maxillary anterior region. This additional tooth structure may cause disturbance in eruption or position of the adjacent teeth. About 8–25% of supernumerary teeth in the anterior region erupt spontaneously. Un-erupted supernumerary teeth are incidentally identified on a routine radiographic examination. Dens invaginatus is a rare tooth malformation showing an in-folding of enamel and dentine of affected tooth sometimes extending deep into the pulp cavity and the root portion. We report a case of un-erupted mesiodens causing midline diastema of permanent teeth subsequently corrected following extraction of mesiodens. Dens invaginatus was identified affecting the un-erupted mesiodens. It is rare to find dens invaginatus associated with a supernumerary tooth and only 10 such instances of dens invaginatus affecting supernumerary teeth have been reported in the English literature. PMID:25737852

  16. Rare association of dens invaginatus with impacted mesiodens - A case report.

    Science.gov (United States)

    Patil, Prashant B; Chaudhari, Smitha G; Goel, Ankit; Agarwal, Pooja

    2012-01-01

    Mesiodens is a supernumerary tooth occupying the position in the maxillary anterior region. This additional tooth structure may cause disturbance in eruption or position of the adjacent teeth. About 8-25% of supernumerary teeth in the anterior region erupt spontaneously. Un-erupted supernumerary teeth are incidentally identified on a routine radiographic examination. Dens invaginatus is a rare tooth malformation showing an in-folding of enamel and dentine of affected tooth sometimes extending deep into the pulp cavity and the root portion. We report a case of un-erupted mesiodens causing midline diastema of permanent teeth subsequently corrected following extraction of mesiodens. Dens invaginatus was identified affecting the un-erupted mesiodens. It is rare to find dens invaginatus associated with a supernumerary tooth and only 10 such instances of dens invaginatus affecting supernumerary teeth have been reported in the English literature.

  17. Anmerkungen zum Stand und zu den Entwicklungstendenzen der Prozeßkostenrechnung

    OpenAIRE

    Fischer, Thomas

    1994-01-01

    Anmerkungen zum Stand und zu den Entwicklungstendenzen der Prozeßkostenrechnung / A. G. Coenenberg ; Th. M. Fischer. - In: Prozeßkostenrechnung / Wolfgang Männel (Hrsg.). - Wiesbaden : Gabler, 1994. - S. 23-25. - (Kostenrechnungspraxis : Sonderheft ; 1994/1)

  18. [Ulrike Plath. Esten und Deutsche in den baltischen Provinzen Russlands] / Olaf Mertelsmann

    Index Scriptorium Estoniae

    Mertelsmann, Olaf, 1969-

    2013-01-01

    Arvustus: Plath, Ulrike. Esten und Deutsche in den baltischen Provinzen Russlands: Freundheitskonstruktionen, lebenswelten, Kolonialphantasien 1750-1810 (Veröffenlichungen des Nordost-Instituts, Bd. 11.)Harrasowitz. Wiesbaden 2011

  19. Good-Practice-Ansätze für den Dienstleistungseinkauf

    OpenAIRE

    Hänsel, Martin; Hofmann, Erik

    2017-01-01

    Die Performance Excellence Studie des Lehrstuhls für Logistikmanagement der Hochschule St. Gallen (HSG) zeigt auf, was moderne Unternehmen tun müssen, wenn sie den Einkauf von Dienstleistungen zeitgemäss handhaben wollen.

  20. How can macroscopically normal peritoneum contribute to the pathogenesis of endometriosis?

    Science.gov (United States)

    Fassbender, Amelie; Overbergh, Lut; Verdrengh, Eefje; Kyama, Cleophas M; Vodolazakaia, Alexandra; Bokor, Attila; Meuleman, Christel; Peeraer, Karen; Tomassetti, Carla; Waelkens, Etienne; Mathieu, Chantal; D'Hooghe, Thomas

    2011-09-01

    This study indicates that the immunobiology of macroscopically normal peritoneum is relevant to understand the pathogenesis of endometriosis. Peritoneal interleukin 6, interleukin 12, and ferritin were differentially expressed in women with and without endometriosis. Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  1. Q fever in pregnant Goats: PAthogenesis and excretion of Coxiella burnetii

    NARCIS (Netherlands)

    Roest, H.I.J.; Gelderen, van E.; Dinkla, A.; Frangoulidis, D.; Zijderveld, van F.G.; Rebel, J.M.J.; Keulen, van L.J.M.

    2012-01-01

    Coxiella burnetii is an intracellular bacterial pathogen that causes Q fever. Infected pregnant goats are a major source of human infection. However, the tissue dissemination and excretion pathway of the pathogen in goats are still poorly understood. To better understand Q fever pathogenesis, we

  2. Den danske magtelite bør dæmpe sin begejstring over Macron

    DEFF Research Database (Denmark)

    Ellersgaard, Christoph

    2017-01-01

    Eliten. Den franske præsident, der caster sig selv som en politisk fornyer, er præget af elitære institutioner og netværk gennem hele sin karriere.......Eliten. Den franske præsident, der caster sig selv som en politisk fornyer, er præget af elitære institutioner og netværk gennem hele sin karriere....

  3. Expression of the bacteriophage T4 denV structural gene in Escherichia coli

    International Nuclear Information System (INIS)

    Recinos, A. III; Augustine, M.L.; Higgins, K.M.; Lloyd, R.S.

    1986-01-01

    The expression of the T4 denV gene, which previously had been cloned in plasmid constructs downstream of the bacteriophage lambda hybrid promoter-operator oLpR, was analyzed under a variety of growth parameters. Expression of the denV gene product, endonuclease V, was confirmed in DNA repair-deficient Escherichia coli (uvrA recA) by Western blot analyses and by enhancements of resistance to UV irradiation

  4. Den første Karl Gustav-krig 1657-58

    DEFF Research Database (Denmark)

    Olden-Jørgensen, Sebastian

    2008-01-01

    Artiklen diskuterer den første Karl Gustav-krig i forskellige persketiver og konkluderer, at krigen ikke bør opfattes som et dårligt forberedt og uigennemtænkt forsøg på dansk revanche inden for rammerne af en nordisk rivalisering, men snarere som  en velovervejet satsning og et led i den dansk-s...

  5. Loyalitet i praksis:En etnologisk kulturanalyse af fænomenet den loyale forbruger

    OpenAIRE

    Breddam, Mads Dupont

    2015-01-01

    Loyalitet i praksis – en etnologisk kulturanalyse af fænomenet den loyale forbruger , er en kvalitativ kulturanalyse af, hvordan loyalitet skabes i forbindelse med den danske detailhandels - og andelsorganisation Coop og Coops loyalitetsprogram CoopPlus. Undersøgelserne bygger på et empirisk materiale , som hovedsageligt består af kvalitative interviews med en række medlemmer og medejere af Coop samt med medarbejdere i Coops hovedkvarter i Albertslund . Afhandlingen er en praksiografisk under...

  6. Über den Nachrichtenwert von Friedensjournalismus - Ergebnisse einer experimentellen Studie

    OpenAIRE

    Monika Spohrs

    2006-01-01

    Laut Nachrichtenwertforschung hängt die Publikations- und Lesenswürdigkeit von Nachrichtentexten von den Nachrichtenfaktoren der zu publizierenden Ereignisse ab. Als anerkannte Nachrichtenfaktoren gelten beispielsweise Negativität, Vereinfachung und Personifizierung. Friedensjournalistische Arbeiten weichen von diesen Kriterien oft ab, indem sie versuchen, die berichteten Ereignisse in ihrer Komplexität darzustellen, den Fokus nicht auf negative Ereignisse zu legen und auch strukturellen Them...

  7. Den årlige klining af moskéen i Jenné

    DEFF Research Database (Denmark)

    Andreasen, Jørgen

    2007-01-01

    Danske studerende hjælper med kliningen af den store moské i Jenné under 'Mohammed-krisen'. Jenné er et af UNESCO's 'heritage sites' - en by helt bygget i ler. Vedligeholdelse og årlig klining er nødvendig. Moskeen er den største bygning, lukket for ikke-muslimer. Det danske hold fik adgang til m...

  8. Nonsurgical endodontic management of dens invaginatus with open apex: A case report.

    Science.gov (United States)

    Rani, Nidhi; Sroa, Renu B

    2015-01-01

    Dens invaginatus is a rare malformation with a widely varied morphology. It typically affects permanent maxillary lateral incisors, central incisors, and premolars. This article demonstrates rapid management of type II dens invagination with open apex and large periradicular lesion using calcium hydroxide as intracanal medicament for 1-week followed by apical plug formation with mineral trioxide aggregate Plus and lateral condensation of Gutta-percha. At 24-month follow-up, the patient was asymptomatic and lesion was entirely resolved.

  9. Den europæiske drøm - om EU

    DEFF Research Database (Denmark)

    Østergaard, Uffe

    2007-01-01

    Anmeldelse af: Jeremy Rifkin: Den europæiske drøm (Informations Forlag, 2006). Oversat fra engelsk efter: "The European Dream: How Europe's Vision of the Future Is Quietly Eclipsing the American Dream" (2004)......Anmeldelse af: Jeremy Rifkin: Den europæiske drøm (Informations Forlag, 2006). Oversat fra engelsk efter: "The European Dream: How Europe's Vision of the Future Is Quietly Eclipsing the American Dream" (2004)...

  10. Konfliktrettens anvendelighed i den offentlige sektor set i lyset af OK13

    DEFF Research Database (Denmark)

    Høgedahl, Laust; Ibsen, Flemming

    2015-01-01

    eller mægling. Men der er stor forskel på de præmisser og vilkår som konfliktretten bygger på, når den offentlige - og private sektor sammenlignes. I denne artikel præsenteres en kritisk analyse af brugen af konfliktretten i den offentlige sektor set i lyset af OK13 og lærerlockouten. Artiklen viser...

  11. Køn og kærlighed i Den Hebraiske Bibel og tidlig rabbinsk litteratur

    DEFF Research Database (Denmark)

    Schleicher, Marianne

    2014-01-01

    De religiøse grundlæggertekster synes optaget af at sikre kulturens videreførelse gennem entydiggørelse af køn og kærlighed, men den hebræiske bibel og den tidlige rabbinske litteratur skildrer lige så ofte i de mest dramatiske og poetiske passager køn og kærlighed som komplekse, sammensatte, for...

  12. [The etiology and pathogenesis of Sprengel's disease].

    Science.gov (United States)

    Skopichenko, D N

    1999-01-01

    Basing on the analysis of clinico-radiological and functional signs, electromyographic and histological changes in the shoulder girdle (SG) upper extremities muscles, macro- and microscopic investigations of omovertebral formations in the patients with Sprengel disease, and the literature data there was formulated the scheme of etiology and pathogenesis of the inborn high position of shoulder blade. The leading role in the Sprengel disease etiology plays teratogenic exo- or endogenous harmful agent, affecting mesenchymal tissue in the moment of the vertebral column and SG inlay on the 4-5th week of embryogenesis. Underdevelopment and degeneration of the SG muscles, creation of fibrous, fibrous-cartilaginous and osteal tissues due to the embryogenesis disorder occurrence, are playing essential role in pathogenesis of anatomic-functional disorders, causing occurrence of the inborn high position of shoulder blade.

  13. Theories on the Pathogenesis of Endometriosis

    Directory of Open Access Journals (Sweden)

    Samer Sourial

    2014-01-01

    Full Text Available Endometriosis is a common, chronic inflammatory disease defined by the presence of extrauterine endometrial tissue. The aetiology of endometriosis is complex and multifactorial, where several not fully confirmed theories describe its pathogenesis. This review examines existing theories on the initiation and propagation of different types of endometriotic lesions, as well as critically appraises the myriad of biologically relevant evidence that support or oppose each of the proposed theories. The current literature suggests that stem cells, dysfunctional immune response, genetic predisposition, and aberrant peritoneal environment may all be involved in the establishment and propagation of endometriotic lesions. An orchestrated scientific and clinical effort is needed to consider all factors involved in the pathogenesis of this multifaceted disease and to propose novel therapeutic targets to reach effective treatments for this distressing condition.

  14. [The pathogenesis of small-plaque parapsoriasis].

    Science.gov (United States)

    Olisova, O Iu; Kop'eva, T N

    1994-01-01

    The paper deals with the origin of parapsoriasis nodularis, which in its micronodular variant belongs to chronic dermatosis and has a clear-cut clinical and histological appearance. The disease arises most frequently after stress and occurs for the most part in middle-aged males. The leading role in pathogenesis of parapsoriasis nodularis is played by cellular immunity as indicated by reduced count of T-lymphocytes, active T-lymphocytes as well as the emergence of delayed hypersensitivity.

  15. Osmotin, a Pathogenesis-Related Protein

    Czech Academy of Sciences Publication Activity Database

    Viktorová, J.; Krásný, Lukáš; Kamlar, M.; Nováková, M.; Macková, M.; Macek, T.

    2012-01-01

    Roč. 13, č. 7 (2012), s. 672-681 ISSN 1389-2037 Grant - others:GA ČR(CZ) GAP501/11/1654; GA ČR(CZ) GA522/09/1693 Program:GA; GA Institutional support: RVO:61388971 Keywords : osmotin * pathogenesis-related proteins * antifungal activity Subject RIV: CE - Biochemistry Impact factor: 2.326, year: 2012

  16. Acute pancreatitis: Etiology and common pathogenesis

    OpenAIRE

    Wang, Guo-Jun; Gao, Chun-Fang; Wei, Dong; Wang, Cun; Ding, Si-Qin

    2009-01-01

    Acute pancreatitis is an inflammatory disease of the pancreas. The etiology and pathogenesis of acute pancreatitis have been intensively investigated for centuries worldwide. Many causes of acute pancreatitis have been discovered, but the pathogenetic theories are controversial. The most common cause of acute pancreatitis is gallstone impacting the distal common bile-pancreatic duct. The majority of investigators accept that the main factors for acute billiary pancreatitis are pancreatic hype...

  17. Complex endodontic treatment of an immature type III dens invaginatus. A case report.

    Science.gov (United States)

    Fregnani, E R; Spinola, L F B; Sônego, J R O; Bueno, C E S; De Martin, A S

    2008-10-01

    To report the endodontic treatment of an immature maxillary central incisor with dens invaginatus. Dens invaginatus is a rare malformation of teeth, probably resulting from an infolding of the dental papilla during tooth development. The present case describes the complex endodontic treatment of a type III dens invaginatus in an immature maxillary central incisor with a necrotic pulp and abscess formation. The initial treatment goal was to achieve apexification of the pseudocanal root and conservative root canal treatment in the main canal. Following 1-year of treatment with calcium hydroxide dressings, radiography revealed a healing response, but no sign of a hard tissue barrier at the apex. Periapical surgery with the placement of a zinc oxide cement (IRM) root-end filling was considered successful at the 4-year follow-up. The complexity of the canal system and open apex in dens invaginatus present a challenge to endodontic treatment. Correct diagnosis and treatment planning are fundamental to treatment of dens invaginatus. Periapical surgery is indicated in cases of unsuccessful apexification in immature teeth with dens invaginatus and nonvital pulp.

  18. Double Dens Invaginatus with Multiple Canals in a Maxillary Central Incisor: Retreatment and Managing Complications.

    Science.gov (United States)

    Zoya, Asma; Ali, Sajid; Alam, Sharique; Tewari, Rajendra K; Mishra, Surendra K; Kumar, Ashok; Andrabi, Syed Mukhtar-Un-Nisar

    2015-11-01

    Dens invaginatus is a developmental anomaly that often presents a perplexing challenge to the endodontist. It involves the maxillary central incisor less commonly than the maxillary lateral incisor. Double dens invaginatus is even rarer. Herein a unique case of dens invaginatus in a maxillary central incisor is presented. The tooth had an inadequate previous root canal treatment. On retreatment, multiple canals and double dens invaginatus were found. The invaginations were Oehlers type 3b and type 2. The complex morphology was diagnosed and confirmed with cone-beam computed tomography imaging and managed with a combined surgical and orthograde approach. Four canals and a blind sac along with an open apex were found. There were many intercommunications between the canals. During the treatment, a complication of a separated instrument occurred, which was managed successfully. The 1-year follow-up shows successful outcome of the treatment. Dens invaginatus may be more complicated than it seems. It needs meticulous treatment by a specialist. Failure or a delay in referring the case to a specialty setting may further increase the complications. With the advancements in equipment and materials, it is possible to save even severe cases of dens invaginatus. Copyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  19. [Anatomy and pathogenesis of diverticular disease].

    Science.gov (United States)

    Wedel, T; Böttner, M

    2014-04-01

    Although diverticular disease is one of the most frequent gastrointestinal disorders the pathogenesis is not yet sufficiently clarified. The aim is to define the anatomy and pathogenesis of diverticular disease considering the risk factors and description of structural and functional alterations of the bowel wall. This article gives an appraisal of the literature, presentation and evaluation of classical etiological factors, analysis and discussion of novel pathogenetic concepts. Colonic diverticulosis is defined as an acquired out-pouching of multiple and initially asymptomatic pseudodiverticula through muscular gaps in the colon wall. Diverticular disease is characterized by diverticular bleeding and/or inflammatory processes (diverticulitis) with corresponding complications (e.g. abscess formation, fistula, covered and open perforation, peritonitis and stenosis). Risk factors for diverticular disease include increasing age, genetic predisposition, congenital connective tissue diseases, low fiber diet, high meat consumption and pronounced overweight. Alterations of connective tissue cause a weakening of preformed exit sites of diverticula and rigidity of the bowel wall with reduced flexibility. It is assumed that intestinal innervation disorders and structural alterations of the musculature induce abnormal contractile patterns with increased intraluminal pressure, thereby promoting the development of diverticula. Moreover, an increased release of pain-mediating neurotransmitters is considered to be responsible for persistent pain in chronic diverticular disease. According to the present data the pathogenesis of diverticular disease cannot be attributed to a single factor but should be considered as a multifactorial event.

  20. Immunogenetics and genetic susceptibility in the pathogenesis of autoimmune hepatitis

    Directory of Open Access Journals (Sweden)

    Das Anup K

    2014-11-01

    Full Text Available vAutoimmune hepatitis is a progressive liver disease. Its pathogenesis is unclear, but needs a ‘trigger’ to initiate the disease in a genetically susceptible person. The susceptibility is partly related to MHCII class genes, and more so with human leukocyte antigen (HLA. Several mechanisms have been proposed which, however, cannot fully explain the immunologic findings in autoimmune hepatitis. The susceptibility to any autoimmune disease is determined by several factors where genetic and immunological alterations, along with, environmental factor are active. MHCII antigens as a marker for AIH, or a predictor of treatment response and prognosis has been investigated. Since MHCII antigens show significant ethnic heterogeneity, mutations in MHCII may merely act as only precursors of the surface markers of immune cells, which can be of significance, because the changes in HLA and MHC are missing in certain populations. One such marker is the CTLA-4 (CD152 gene mutation, reported in the phenotypes representing susceptibility to AIH. Other candidate genes of cytokines, TNF, TGF-beta1 etc, have also been investigated but with unvalidated results. Paediatric AIH show differences in genetic susceptibility. Genetic susceptibility or resistance to AIH may be associated with polypeptides in DRB1 with certain amino-acid sequences. Understanding which genes are implicated in genesis and/or disease progression will obviously help to identify key pathways in AIH and provide better insights into its pathogenesis. But studies to identify responsible genes are complex because of the complex trait of AIH.