WorldWideScience

Sample records for understanding complex plasma

  1. Introduction to Complex Plasmas

    CERN Document Server

    Bonitz, Michael; Ludwig, Patrick

    2010-01-01

    Complex plasmas differ from traditional plasmas in many ways: these are low-temperature high pressure systems containing nanometer to micrometer size particles which may be highly charged and strongly interacting. The particles may be chemically reacting or be in contact with solid surfaces, and the electrons may show quantum behaviour. These interesting properties have led to many applications of complex plasmas in technology, medicine and science. Yet complex plasmas are extremely complicated, both experimentally and theoretically, and require a variety of new approaches which go beyond standard plasma physics courses. This book fills this gap presenting an introduction to theory, experiment and computer simulation in this field. Based on tutorial lectures at a very successful recent Summer Institute, the presentation is ideally suited for graduate students, plasma physicists and experienced undergraduates.

  2. Kinetics of complex plasmas

    CERN Document Server

    Sodha, Mahendra Singh

    2014-01-01

    The presentation in the book is based on charge balance on the dust particles, number and energy balance of the constituents and atom-ion-electron interaction in the gaseous plasma. Size distribution of dust particles, statistical mechanics, Quantum effects in electron emission from and accretion on dust particles and nonlinear interaction of complex plasmas with electric and electromagnetic fields have been discussed in the book. The book introduces the reader to basic concepts and typical applications. The book should be of use to researchers, engineers and graduate students.

  3. Complex plasmas scientific challenges and technological opportunities

    CERN Document Server

    Lopez, Jose; Becker, Kurt; Thomsen, Hauke

    2014-01-01

    This book provides the reader with an introduction to the physics of complex plasmas, a discussion of the specific scientific and technical challenges they present, and an overview of their potential technological applications. Complex plasmas differ from conventional high-temperature plasmas in several ways: they may contain additional species, including nanometer- to micrometer-sized particles, negative ions, molecules and radicals, and they may exhibit strong correlations or quantum effects. This book introduces the classical and quantum mechanical approaches used to describe and simulate complex plasmas. It also covers some key experimental techniques used in the analysis of these plasmas, including calorimetric probe methods, IR absorption techniques and X-ray absorption spectroscopy. The final part of the book reviews the emerging applications of microcavity and microchannel plasmas, the synthesis and assembly of nanomaterials through plasma electrochemistry, the large-scale generation of ozone using mi...

  4. Plasma Dispersion Functions for Complex Frequencies

    Energy Technology Data Exchange (ETDEWEB)

    Pavlov, S. S.; Castejon, F.

    2005-07-01

    Plasma dispersion functions for complex wave propagation frequency in the weak relativistic regime for arbitrary longitudinal refractive index are estimated and presented in this work. These functions, that are know as Shkarofsky functions in the case of real frequency, are estimated using a new method that avoids the singularities that appear in previous calculations shown in the preceding literature. These results can be used to obtain the properties of plasma instabilities in the weakly relativistic regime. (Author) 14 refs.

  5. Plasma Dispersion Functions for Complex Frequencies

    International Nuclear Information System (INIS)

    Pavlov, S. S.; Castejon, F.

    2005-01-01

    Plasma dispersion functions for complex wave propagation frequency in the weak relativistic regime for arbitrary longitudinal refractive index are estimated and presented in this work. These functions, that are know as Shkarofsky functions in the case of real frequency, are estimated using a new method that avoids the singularities that appear in previous calculations shown in the preceding literature. These results can be used to obtain the properties of plasma instabilities in the weakly relativistic regime. (Author) 14 refs

  6. Dissipative dark soliton in a complex plasma.

    Science.gov (United States)

    Heidemann, R; Zhdanov, S; Sütterlin, R; Thomas, H M; Morfill, G E

    2009-04-03

    The observation of a dark soliton in a three-dimensional complex plasma containing monodisperse microparticles is presented. We perform our experiments using neon gas in the bulk plasma of an rf discharge. A gas temperature gradient of 500K/m is applied to balance gravity and to levitate the particles in the bulk plasma. The wave is excited by a short voltage pulse on the electrodes of the radio frequency discharge chamber. It is found that the wave propagates with constant speed. The propagation time of the dark soliton is approximately 20 times longer than the damping time.

  7. Understanding SOL plasma turbulence by interchange motions

    Czech Academy of Sciences Publication Activity Database

    Horáček, Jan; Pitts, R. A.; Nielsen, A.H.; Garcia, O.E.

    2007-01-01

    Roč. 52, č. 16 (2007), s. 192-193 ISSN 0003-0503. [Annual meeting of the division of plasma physics/49th./. Orlando , 12.11.2007-16.11.2007] Grant - others:-(XE) European Training fellowships and Grants (Euratom), EDGETURB Institutional research plan: CEZ:AV0Z20430508 Keywords : tokamak * plasma * scrape-off layer * turbulence * interchange instability Subject RIV: BL - Plasma and Gas Discharge Physics http://meetings.aps.org/Meeting/DPP07/Event/70125

  8. Vortex formation in a complex plasma

    Science.gov (United States)

    Ishihara, Osamu

    Complex plasma experiments in ground-based laboratories as well as in microgravity conditions have shown the formation of vortex structures in various conditions (e.g., 1,2,3,4). The vortex structures formed in a complex plasma are visible by naked eyes with the help of irradiating laser and the individual dust particles in the structure give us the opportunity to study detailed physics of the commonly observed natural phenomena known such as tornadoes, typhoons, hurricanes and dust devils. Based on the Navier-Stokes equation with proper complex plasma conditions we analyze as much as possible in a universal way the vortex structure and clarifies the role of the controlling parameters like flow velocity and external magnetic field. 1. G. E. Morfill,H. M. Thomas, U. Konopka,H. Rothermel, M. Zuzic, A. Ivlev, and J. Goree, Phys,. Rev. Lett. 83, 1598 (1999). 2. E. Nebbat and R. Annou, Phys. Plasmas 17, 093702 (2010). 3. Y. Saitou and O. Ishihara, Phys. Rev. Lett. 111, 185003 (2013). 4. V. N. Tsytovich and N. G. Gusein-zade, Plasma Phys. Rep. 39, 515 (2013).

  9. Complex Plasma Research Under Extreme Conditions

    International Nuclear Information System (INIS)

    Ishihara, Osamu

    2008-01-01

    Complex plasma research under extreme conditions is described. The extreme conditions include low-dimensionality for self-organized structures of dust particles, dust magnetization in high magnetic field, criticality in phase transition, and cryogenic environment for Coulomb crystals and dust dynamics.

  10. Understanding Supply Networks from Complex Adaptive Systems

    Directory of Open Access Journals (Sweden)

    Jamur Johnas Marchi

    2014-10-01

    Full Text Available This theoretical paper is based on complex adaptive systems (CAS that integrate dynamic and holistic elements, aiming to discuss supply networks as complex systems and their dynamic and co-evolutionary processes. The CAS approach can give clues to understand the dynamic nature and co-evolution of supply networks because it consists of an approach that incorporates systems and complexity. This paper’s overall contribution is to reinforce the theoretical discussion of studies that have addressed supply chain issues, such as CAS.

  11. Understanding Complex Construction Systems Through Modularity

    DEFF Research Database (Denmark)

    Jensen, Tor Clarke; Bekdik, Baris; Thuesen, Christian

    2014-01-01

    finds that the main driver of complexity is the fragmentation of the design and production, which causes the production modules to construct and install new product types and variants for each project as the designers are swapped for every project. The many interfaces are characteristics of an integral......This paper develops a framework for understanding complexity in construction projects by combining theories of complexity management and modularization. The framework incorporates three dimensions of product, process, and organizational modularity with the case of gypsum wall elements. The analysis...... system, rather than a modular, although the industry forces modular organizational structures. This creates a high complexity degree caused by the non-alignment of building parts and organizations and the frequent swapping of modules....

  12. Particle detection algorithms for complex plasmas

    Science.gov (United States)

    Mohr, D. P.; Knapek, C. A.; Huber, P.; Zaehringer, E.

    2018-01-01

    The micrometer-sized particles in a complex plasma can be directly visualized and recorded by digital video cameras. To analyze the dynamics of single particles, reliable algorithms are required to accurately determine their positions to sub-pixel accuracy from the recorded images. Here, we combine the algorithms with common techniques for image processing, and we study several algorithms, pre- and post-processing methods, and the impact of the choice of threshold parameters.

  13. 'Complexity' and anomalous transport in space plasmas

    International Nuclear Information System (INIS)

    Chang, Tom; Wu Chengchin

    2002-01-01

    'Complexity' has become a hot topic in nearly every field of modern physics. Space plasma is of no exception. In this paper, it is demonstrated that the sporadic and localized interactions of magnetic coherent structures are the origin of 'complexity' in space plasmas. The intermittent localized interactions, which generate the anomalous diffusion, transport, and evolution of the macroscopic state variables of the overall dynamical system, may be modeled by a triggered (fast) localized chaotic growth equation of a set of relevant order parameters. Such processes would generally pave the way for the global system to evolve into a 'complex' state of long-ranged interactions of fluctuations, displaying the phenomenon of forced and/or self-organized criticality. An example of such type of anomalous transport and evolution in a sheared magnetic field is provided via two-dimensional magnetohydrodynamic simulations. The coarse-grained dissipation due to the intermittent triggered interactions among the magnetic coherent structures induces a 'fluctuation-induced nonlinear instability' that reconfigures the sheared magnetic field into an X-point magnetic geometry (in the mean field sense), leading to the anomalous acceleration of the magnetic coherent structures. A phenomenon akin to such type of anomalous transport and acceleration, the so-called bursty bulk flows, has been commonly observed in the plasma sheet of the Earth's magnetotail

  14. Agglomeration of microparticles in complex plasmas

    International Nuclear Information System (INIS)

    Du, Cheng-Ran; Thomas, Hubertus M.; Ivlev, Alexei V.; Konopka, Uwe; Morfill, Gregor E.

    2010-01-01

    Agglomeration of highly charged microparticles was observed and studied in complex plasma experiments carried out in a capacitively coupled rf discharge. The agglomeration was caused by strong waves triggered in a particle cloud by decreasing neutral gas pressure. Using a high-speed camera during this unstable regime, it was possible to resolve the motion of individual microparticles and to show that the relative velocities of some particles were sufficiently high to overcome the mutual Coulomb repulsion and hence to result in agglomeration. After stabilizing the cloud again through the increase of the pressure, we were able to observe the aggregates directly with a long-distance microscope. We show that the agglomeration rate deduced from our experiments is in good agreement with theoretical estimates. In addition, we briefly discuss the mechanisms that can provide binding of highly charged microparticles in a plasma.

  15. Dependency visualization for complex system understanding

    Energy Technology Data Exchange (ETDEWEB)

    Smart, J. Allison Cory [Univ. of California, Davis, CA (United States)

    1994-09-01

    With the volume of software in production use dramatically increasing, the importance of software maintenance has become strikingly apparent. Techniques now sought and developed for reverse engineering and design extraction and recovery. At present, numerous commercial products and research tools exist which are capable of visualizing a variety of programming languages and software constructs. The list of new tools and services continues to grow rapidly. Although the scope of the existing commercial and academic product set is quite broad, these tools still share a common underlying problem. The ability of each tool to visually organize object representations is increasingly impaired as the number of components and component dependencies within systems increases. Regardless of how objects are defined, complex ``spaghetti`` networks result in nearly all large system cases. While this problem is immediately apparent in modem systems analysis involving large software implementations, it is not new. As will be discussed in Chapter 2, related problems involving the theory of graphs were identified long ago. This important theoretical foundation provides a useful vehicle for representing and analyzing complex system structures. While the utility of directed graph based concepts in software tool design has been demonstrated in literature, these tools still lack the capabilities necessary for large system comprehension. This foundation must therefore be expanded with new organizational and visualization constructs necessary to meet this challenge. This dissertation addresses this need by constructing a conceptual model and a set of methods for interactively exploring, organizing, and understanding the structure of complex software systems.

  16. Nuclear Fusion Research Understanding Plasma-Surface Interactions

    CERN Document Server

    Clark, Robert E.H

    2005-01-01

    It became clear in the early days of fusion research that the effects of the containment vessel (erosion of "impurities") degrade the overall fusion plasma performance. Progress in controlled nuclear fusion research over the last decade has led to magnetically confined plasmas that, in turn, are sufficiently powerful to damage the vessel structures over its lifetime. This book reviews current understanding and concepts to deal with this remaining critical design issue for fusion reactors. It reviews both progress and open questions, largely in terms of available and sought-after plasma-surface interaction data and atomic/molecular data related to these "plasma edge" issues.

  17. Structure Formation in Complex Plasma - Quantum Effects in Cryogenic Complex Plasmas

    Science.gov (United States)

    2014-09-26

    particle moves upward against gravity. Dust particles form a fat torus structure in a complex plasma with a magnetic field. The toroidal axis is...perpendicular to the magnetic field. The dust particles rotate both in the toroidal and the poloidal directions. Under a certain value of the magnetic

  18. Listening, understanding and interpreting: reflections on complexity.

    Science.gov (United States)

    Lichtenberg, J D

    1999-08-01

    Beginning with the premise that a contemporary approach to analytic exchanges has become far more complex and multi-faceted than in earlier times, the author addresses listening, understanding and interpreting. The opening section presents the basis and utility of a proposed theory of five motivational systems and identifies the need for a shift from conceptualising 'structures' to systems. The nature of communication during analysis is considered from several standpoints including listening for needs and intentions, the place of theory as a background to listening, an optimal state for analysand and analyst, and the significance of the distinction between inner monologue and spoken discourse. Differing views of free association and narrative, especially questions arising from findings of the 'adult attachment interview', are discussed. The patient's sensitivity to the presence and influence of the analyst and the analyst's recognition of non-verbal as well as verbal communications completes this section. In the final section a brief clinical example is presented to introduce a differentiated depiction of the variety of interventions that analysts employ. Throughout the paper, the author presents his view of listening, understanding and interpreting in dialectic contrast with the many other perspectives held by analysts in this period of theoretical pluralism.

  19. Complex and Dusty Plasmas From Laboratory to Space

    CERN Document Server

    Fortov, Vladimir E

    2009-01-01

    Dusty or complex plasmas are plasmas containing solid or liquid charged particles referred to as dust. Naturally occurring in space, on earth dust plays a key role in plasma applications associated with etching technologies in microelectronics. International in scope, this volume covers theoretical and application research.

  20. Complexities of Parental Understanding of Phenylketonuria

    Science.gov (United States)

    Sibinga, Maarten S.; Friedman, C. Jack

    1971-01-01

    Parental understanding of PKU, investigated through a questionnaire, was evaluated as to completeness and with respect to distortion. Education of parents was found to be unrelated to their understanding or tendency to distort. Effectiveness of the pediatrician's communication with parents is discussed. (Author/KW)

  1. Understanding the Etiology of Tuberous Sclerosis Complex

    Science.gov (United States)

    2012-07-01

    of life as infantile spasms that are unresponsive to conventional anti-epileptic drug therapies (Curatolo et al., 2001; Holmes and Stafstrom, 2007... Infantile spasms in tuberous sclerosis complex. Brain Dev 23:502-507. DiMario FJ, Jr. (2004) Brain abnormalities in tuberous sclerosis complex. J...on chromosome 16. Cell, 75, 1305–1315. 3. Curatolo, P., Seri, S., Verdecchia, M. and Bombardieri, R. (2001) Infantile spasms in tuberous sclerosis

  2. Towards intelligent video understanding applied to plasma facing component monitoring

    International Nuclear Information System (INIS)

    Martin, V.; Travere, J.M.; Moncada, V.; Bremond, F.

    2011-01-01

    In this paper, we promote intelligent plasma facing component video monitoring for both real-time purposes (machine protection issues) and post event analysis purposes (plasma-wall interaction understanding). We propose a vision-based system able to automatically detect and classify into different pre-defined categories thermal phenomena such as localized hot spots or transient thermal events (e.g. electrical arcing) from infrared imaging data of PFCs. This original computer vision system is made intelligent by endowing it with high level reasoning (i.e. integration of a priori knowledge of thermal event spatio-temporal properties to guide the recognition), self-adaptability to varying conditions (e.g. different thermal scenes and plasma scenarios), and learning capabilities (e.g. statistical modelling of event behaviour based on training samples). (authors)

  3. School Phobia: Understanding a Complex Behavioural Response

    Science.gov (United States)

    Chitiyo, Morgan; Wheeler, John J.

    2006-01-01

    School phobia affects about 5% of the school-age population. If left untreated, school phobia can have devastating long-term consequences in children challenged by this condition. Various treatment approaches have been used to explore this complex behavioural response, major among them being the psychoanalytic, psychodynamic, pharmacological and…

  4. Understanding the Complexity of a Rising China

    Science.gov (United States)

    2016-05-26

    at the macro-level are determined by security interests derived from anarchy.48 From this mindset , Waltz attempted to draw on elements of complexity...artificialities. The restrictions prevented the expansion of the PRC multinational corporations, as it was more difficult for Chinese entrepreneurs to receive...unknowable.” This does not mean there is no point in planning. It simply establishes a mindset that there are no universal truths or solution sets. All

  5. Computer simulation of complexity in plasmas

    International Nuclear Information System (INIS)

    Hayashi, Takaya; Sato, Tetsuya

    1998-01-01

    By making a comprehensive comparative study of many self-organizing phenomena occurring in magnetohydrodynamics and kinetic plasmas, we came up with a hypothetical grand view of self-organization. This assertion is confirmed by a recent computer simulation for a broader science field, specifically, the structure formation of short polymer chains, where the nature of the interaction is completely different from that of plasmas. It is found that the formation of the global orientation order proceeds stepwise. (author)

  6. Understanding the Complexity of Teacher Reflection in Action Research

    Science.gov (United States)

    Luttenberg, Johan; Meijer, Paulien; Oolbekkink-Marchand, Helma

    2017-01-01

    Reflection in action research is a complex matter, as is action research itself. In recent years, complexity science has regularly been called upon in order to more thoroughly understand the complexity of action research. The present article investigates the benefits that complexity science may yield for reflection in action research. This article…

  7. Understanding complex interactions using social network analysis.

    Science.gov (United States)

    Pow, Janette; Gayen, Kaberi; Elliott, Lawrie; Raeside, Robert

    2012-10-01

    The aim of this paper is to raise the awareness of social network analysis as a method to facilitate research in nursing research. The application of social network analysis in assessing network properties has allowed greater insight to be gained in many areas including sociology, politics, business organisation and health care. However, the use of social networks in nursing has not received sufficient attention. Review of literature and illustration of the application of the method of social network analysis using research examples. First, the value of social networks will be discussed. Then by using illustrative examples, the value of social network analysis to nursing will be demonstrated. The method of social network analysis is found to give greater insights into social situations involving interactions between individuals and has particular application to the study of interactions between nurses and between nurses and patients and other actors. Social networks are systems in which people interact. Two quantitative techniques help our understanding of these networks. The first is visualisation of the network. The second is centrality. Individuals with high centrality are key communicators in a network. Applying social network analysis to nursing provides a simple method that helps gain an understanding of human interaction and how this might influence various health outcomes. It allows influential individuals (actors) to be identified. Their influence on the formation of social norms and communication can determine the extent to which new interventions or ways of thinking are accepted by a group. Thus, working with key individuals in a network could be critical to the success and sustainability of an intervention. Social network analysis can also help to assess the effectiveness of such interventions for the recipient and the service provider. © 2012 Blackwell Publishing Ltd.

  8. On bias of kinetic temperature measurements in complex plasmas

    DEFF Research Database (Denmark)

    Kantor, M.; Moseev, D.; Salewski, Mirko

    2014-01-01

    The kinetic temperature in complex plasmas is often measured using particle tracking velocimetry. Here, we introduce a criterion which minimizes the probability of faulty tracking of particles with normally distributed random displacements in consecutive frames. Faulty particle tracking results i...

  9. Study of Complex Plasmas with Magnetic Dipoles

    Science.gov (United States)

    2017-10-10

    with thermal energy much larger than Coulomb energy , showing the nature of a weak coupling. Such a weak coupling among particles is the basis for the...by contract FA2386-12-1-4077 (Principal investigator: O. Ishihara). Introduction: In a plasma, charged particles move freely with thermal energy ...14-1-4021 5c.  PROGRAM ELEMENT NUMBER 61102F 6. AUTHOR(S) Osamu Ishihara 5d.   PROJECT NUMBER 5e.  TASK NUMBER 5f.  WORK UNIT NUMBER 7. PERFORMING

  10. Ideal gas behavior of a strongly coupled complex (dusty) plasma.

    Science.gov (United States)

    Oxtoby, Neil P; Griffith, Elias J; Durniak, Céline; Ralph, Jason F; Samsonov, Dmitry

    2013-07-05

    In a laboratory, a two-dimensional complex (dusty) plasma consists of a low-density ionized gas containing a confined suspension of Yukawa-coupled plastic microspheres. For an initial crystal-like form, we report ideal gas behavior in this strongly coupled system during shock-wave experiments. This evidence supports the use of the ideal gas law as the equation of state for soft crystals such as those formed by dusty plasmas.

  11. Simple, complex and hyper-complex understanding - enhanced sensitivity in observation of information

    DEFF Research Database (Denmark)

    Bering Keiding, Tina

    enhanced transparency in selection of understanding as well as enhanced sensitivity and definition in dept. The contribution suggest that we distinguish between three types of understanding; simple, complex and hyper-complex understanding. Simple understanding is the simultaneous selection of understanding......-order observation. Hyper-complex, or third-order observation, observes conditions for indication; that is conditions for actualization of the specific form of the difference constructed through second-order observation. The three types are partly deduced from Luhmanns concept of understanding, partly generated...

  12. Giant plasma membrane vesicles: models for understanding membrane organization.

    Science.gov (United States)

    Levental, Kandice R; Levental, Ilya

    2015-01-01

    The organization of eukaryotic membranes into functional domains continues to fascinate and puzzle cell biologists and biophysicists. The lipid raft hypothesis proposes that collective lipid interactions compartmentalize the membrane into coexisting liquid domains that are central to membrane physiology. This hypothesis has proven controversial because such structures cannot be directly visualized in live cells by light microscopy. The recent observations of liquid-liquid phase separation in biological membranes are an important validation of the raft hypothesis and enable application of the experimental toolbox of membrane physics to a biologically complex phase-separated membrane. This review addresses the role of giant plasma membrane vesicles (GPMVs) in refining the raft hypothesis and expands on the application of GPMVs as an experimental model to answer some of key outstanding problems in membrane biology. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. Towards intelligent video understanding applied to plasma facing component monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Martin, V.; Bremond, F. [INRIA, Pulsa team-project, Sophia Antipolis (France); Travere, J.M. [CEA IRFM, Saint Paul-lez-Durance (France); Moncada, V.; Dunand, G. [Sophia Conseil Company, Sophia Antipolis (France)

    2011-07-01

    Infrared thermography has become a routine diagnostic in many magnetic fusion devices to monitor the heat loads on the plasma facing components (PFCs) for both physics studies and machine protection. The good results of the developed systems obtained so far motivate the use of imaging diagnostics for control, especially during long pulse tokamak operation (e.g. lasting several minutes). In this paper, we promote intelligent monitoring for both real-time purposes (machine protection issues) and post event analysis purposes (PWI understanding). We propose a vision-based system able to automatically detect and classify into different pre-defined categories phenomena as localized hot spots, transient thermal events (e.g. electrical arcing), and unidentified flying objects (UFOs) as dusts from infrared imaging data of PFCs. This original vision system is made intelligent by endowing it with high-level reasoning (i.e. integration of a priori knowledge of thermal event spatial and temporal properties to guide the recognition), self-adaptability to varying conditions (e.g. different plasma scenarios), and learning capabilities (e.g. statistical modelling of thermal event behaviour based on training samples). This approach has been already successfully applied to the recognition of one critical thermal event at Tore Supra. We present here latest results of its extension for the recognition of others thermal events (e.g., B{sub 4}C flakes, impact of fast particles, UFOs) and show how extracted information can be used during plasma operation at Tore Supra to improve the real time control system, and for further analysis of PFC aging. This document is composed of an abstract followed by the slides of the presentation. (authors)

  14. Understanding Learner Agency as a Complex Dynamic System

    Science.gov (United States)

    Mercer, Sarah

    2011-01-01

    This paper attempts to contribute to a fuller understanding of the nature of language learner agency by considering it as a complex dynamic system. The purpose of the study was to explore detailed situated data to examine to what extent it is feasible to view learner agency through the lens of complexity theory. Data were generated through a…

  15. Ecosystemic Complexity Theory of Conflict: Understanding the Fog of Conflict

    Science.gov (United States)

    Brack, Greg; Lassiter, Pamela S.; Hill, Michele B.; Moore, Sarah A.

    2011-01-01

    Counselors often engage in conflict mediation in professional practice. A model for understanding the complex and subtle nature of conflict resolution is presented. The ecosystemic complexity theory of conflict is offered to assist practitioners in navigating the fog of conflict. Theoretical assumptions are discussed with implications for clinical…

  16. Kinetic theory of nonlinear transport phenomena in complex plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Mishra, S. K. [Institute for Plasma Research (IPR), Gandhinagar 382428 (India); Sodha, M. S. [Centre for Energy Studies (CES), Indian Institute of Technology Delhi (IITD), New Delhi 110016 (India)

    2013-03-15

    In contrast to the prevalent use of the phenomenological theory of transport phenomena, a number of transport properties of complex plasmas have been evaluated by using appropriate expressions, available from the kinetic theory, which are based on Boltzmann's transfer equation; in particular, the energy dependence of the electron collision frequency has been taken into account. Following the recent trend, the number and energy balance of all the constituents of the complex plasma and the charge balance on the particles is accounted for; the Ohmic loss has also been included in the energy balance of the electrons. The charging kinetics for the complex plasma comprising of uniformly dispersed dust particles, characterized by (i) uniform size and (ii) the Mathis, Rumpl, and Nordsieck power law of size distribution has been developed. Using appropriate expressions for the transport parameters based on the kinetic theory, the system of equations has been solved to investigate the parametric dependence of the complex plasma transport properties on the applied electric field and other plasma parameters; the results are graphically illustrated.

  17. Investigation of Plasmas Having Complex, Dynamic Evolving Morphology

    Energy Technology Data Exchange (ETDEWEB)

    Bellan, Paul M. [California Inst. of Technology (CalTech), Pasadena, CA (United States)

    2017-01-03

    Three different types of plasmas have been investigated using both experimental and theoretical methods. The first type of plasma is dense, highly ionized, governed by magnetohydrodynamics, and highly dynamic. This plasma is relevant to solar coronal loops, astrophysical jets, and other situations where strong magnetic forces act on the plasma. A well-diagnosed laboratory experiment creates a magnetohydrodynamically driven highly collimated plasma jet. This jet undergoes a kink instability such that it rapidly develops a corkscrew shape. The kink causes lateral acceleration of the jet, and this lateral acceleration drives a Rayleigh-Taylor instability that in turn chokes the current flowing in the jet and causes a magnetic reconnection. The magnetic reconnection causes electron and ion heating as well as emission of whistler waves. This entire sequence of events has been observed, measured in detail, and related to theoretical models. The second type of plasma is a transient rf-produced plasma used as a seed plasma for the magnetohydrodynamic experiments described above. Detailed atomic physics ionization processes have been investigated and modeled. The third type of plasma that has been studied is a dusty plasma where the dust particles are spontaneously growing ice grains. The rapid growth of the ice grains to large size and their highly ordered alignment has been investigated as well as collective motion of the ice grains, including well-defined flows on the surface of nested toroids. In addition to the experimental work described above, several related theoretical models have been developed, most notably a model showing how a complex interaction between gravity and magnetic fields on extremely weakly ionized plasma in an accretion disk provides an electric power source that can drive astrophysical jets associated with the accretion disk. Eighteen papers reporting this work have been published in a wide variety of journals.

  18. Investigation of Plasmas Having Complex, Dynamic Evolving Morphology

    International Nuclear Information System (INIS)

    Bellan, Paul M.

    2017-01-01

    Three different types of plasmas have been investigated using both experimental and theoretical methods. The first type of plasma is dense, highly ionized, governed by magnetohydrodynamics, and highly dynamic. This plasma is relevant to solar coronal loops, astrophysical jets, and other situations where strong magnetic forces act on the plasma. A well-diagnosed laboratory experiment creates a magnetohydrodynamically driven highly collimated plasma jet. This jet undergoes a kink instability such that it rapidly develops a corkscrew shape. The kink causes lateral acceleration of the jet, and this lateral acceleration drives a Rayleigh-Taylor instability that in turn chokes the current flowing in the jet and causes a magnetic reconnection. The magnetic reconnection causes electron and ion heating as well as emission of whistler waves. This entire sequence of events has been observed, measured in detail, and related to theoretical models. The second type of plasma is a transient rf-produced plasma used as a seed plasma for the magnetohydrodynamic experiments described above. Detailed atomic physics ionization processes have been investigated and modeled. The third type of plasma that has been studied is a dusty plasma where the dust particles are spontaneously growing ice grains. The rapid growth of the ice grains to large size and their highly ordered alignment has been investigated as well as collective motion of the ice grains, including well-defined flows on the surface of nested toroids. In addition to the experimental work described above, several related theoretical models have been developed, most notably a model showing how a complex interaction between gravity and magnetic fields on extremely weakly ionized plasma in an accretion disk provides an electric power source that can drive astrophysical jets associated with the accretion disk. Eighteen papers reporting this work have been published in a wide variety of journals.

  19. Understanding complex urban systems multidisciplinary approaches to modeling

    CERN Document Server

    Gurr, Jens; Schmidt, J

    2014-01-01

    Understanding Complex Urban Systems takes as its point of departure the insight that the challenges of global urbanization and the complexity of urban systems cannot be understood – let alone ‘managed’ – by sectoral and disciplinary approaches alone. But while there has recently been significant progress in broadening and refining the methodologies for the quantitative modeling of complex urban systems, in deepening the theoretical understanding of cities as complex systems, or in illuminating the implications for urban planning, there is still a lack of well-founded conceptual thinking on the methodological foundations and the strategies of modeling urban complexity across the disciplines. Bringing together experts from the fields of urban and spatial planning, ecology, urban geography, real estate analysis, organizational cybernetics, stochastic optimization, and literary studies, as well as specialists in various systems approaches and in transdisciplinary methodologies of urban analysis, the volum...

  20. DEVELOPMENT OF COMPLEX EQUIPMENT FOR PLASMA SPRAY CERAMIC COATINGS

    Directory of Open Access Journals (Sweden)

    V. V. Okovity

    2017-01-01

    Full Text Available Develop a set equipment for plasma forming ceramic coatings. The article presents characteristics and parameters of the developed complex equipment for formation of plasma ceramic coatings as well as results of its testing. Methods of research is based on studies of structural elements composite plasma coatings system ZrO2 – Y2O3  obtained  using  developed complex equipment. One of the most effective ways to protect the components from high temperature corrosion and oxidation is formation on the surface of plasma thermal barrier coatings. For thermal barrier coating has very strict requirements: сharacterized by a smooth change of physico-mechanical properties (porosity, microhardness, elastic modulus in the cross section of the metal substrate to the outer ceramic layer; to withstand multiple cycles of thermal cycling from room temperature to the operating temperature; to maintain gastightness under operating conditions and thus ensure a sufficiently high level of adhesive strength. For realization of new technological schemes applying thermal barrier coatings with high operational characteristics was developed, patented and manufactured a range of new equipment. The experiments show that authors developed PBG-1 plasmatron and powder feeder PPBG-04 have at least 2–3 times the service life during the deposition of ceramic materials compared to the standard equipment of the company "Plasma-Technik", by changing the structure of the cathode-anode plasma torch assembly and construction of the delivery unit of the feeder to facilitate the uniform supply of the powder into the plasma jet and the best of his penetration. The result is better plasma coatings with improved operational characteristics: adhesion strength is increased to 1.3–2 times, material utilization in 1.5–1.6 times microhardness 1.2–1.4 times the porosity is reduced by 2–2.5 times.

  1. Numerical experiments on 2D strongly coupled complex plasmas

    International Nuclear Information System (INIS)

    Hou Lujing; Ivlev, A V; Thomas, H M; Morfill, G E

    2010-01-01

    The Brownian Dynamics simulation method is briefly reviewed at first and then applied to study some non-equilibrium phenomena in strongly coupled complex plasmas, such as heat transfer processes, shock wave excitation/propagation and particle trapping, by directly mimicking the real experiments.

  2. Spectral investigation of a complex space charge structure in plasma

    International Nuclear Information System (INIS)

    Gurlui, S.; Dimitriu, D. G.; Ionita, C.; Schrittwieser, R. W.

    2009-01-01

    Complex space charge structures bordered by electrical double layers were spectrally investigated in argon plasma in the domain 400-1000 nm, identifying the lines corresponding to the transitions from different excited states of argon. The electron excitation temperature in the argon atoms was estimated from the spectral lines intensity ratio. (authors)

  3. Understanding Solar Coronal Heating through Atomic and Plasma Physics Experiments

    Science.gov (United States)

    Savin, Daniel Wolf; Arthanayaka, Thusitha; Bose, Sayak; Hahn, Michael; Beiersdorfer, Peter; Brown, Gregory V.; Gekelman, Walter; Vincena, Steve

    2017-08-01

    Recent solar observations suggest that the Sun's corona is heated by Alfven waves that dissipate at unexpectedly low heights in the corona. These observations raise a number of questions. Among them are the problems of accurately quantifying the energy flux of the waves and that of describing the physical mechanism that leads to the wave damping. We are performing laboratory experiments to address both of these issues.The energy flux depends on the electron density, which can be measured spectroscopically. However, spectroscopic density diagnostics have large uncertainties, because they depend sensitively on atomic collisional excitation, de-excitation, and radiative transition rates for multiple atomic levels. Essentially all of these data come from theory and have not been experimentally validated. We are conducting laboratory experiments using the electron beam ion trap (EBIT) at Lawrence Livermore National Laboratory that will provide accurate empirical calibrations for spectroscopic density diagnostics and which will also help to guide theoretical calculations.The observed rapid wave dissipation is likely due to inhomogeneities in the plasma that drive flows and currents at small length scales where energy can be more efficiently dissipated. This may take place through gradients in the Alfvén speed along the magnetic field, which causes wave reflection and generates turbulence. Alternatively, gradients in the Alfvén speed across the field can lead to dissipation through phase-mixing. Using the Large Plasma Device (LAPD) at the University of California Los Angeles, we are studying both of these dissipation mechanisms in the laboratory in order to understand their potential roles in coronal heating.

  4. Exploring the limits of cooperative phenomena using complex plasmas

    International Nuclear Information System (INIS)

    Schwabe, M.; Zhdanov, S.; Ivlev, A. V.; Thomas, H. M.; Morfill, G. E.

    2011-01-01

    With the advancing miniaturization of technological applications, processes on the mesoscale become increasingly important. This is the scale where the individual movement of particles transforms into cooperative behavior-behavior that cannot be explained by investigating the motion of individual particles alone.Complex plasmas are ideally suited to study the limits of cooperative behavior. The time scales of the dynamics of the microparticles embedded in the plasma are such that their movement can be fully resolved, and an investigation on the atomistic (kinetic) level is possible. In addition, complex plasmas can be considered a model system for ordinary fluids: The internal microparticle dynamics is basically undamped and is characterized by the similarity parameters matching those of other fluids. This similarity does not break down even at small scales: For instance, in [2], microparticle droplets comprised of only a few 1000-10000 particles were examined. In these experiments, the Weber number (the ratio of inertia to surface tension forces) matches that of falling water drops. As another example, the onset of a Rayleigh-Taylor instability in a complex plasma can be described by the ordinary dispersion relation, even at scales of only few particle layers. This allows investigating the 'nanoscale' of fluid flows, and, hence, the limits of cooperative behavior.

  5. Understanding complex systems: lessons from Auzoux's and von ...

    Indian Academy of Sciences (India)

    2009-12-09

    Dec 9, 2009 ... Animal and human anatomy is among the most complex systems known, and suitable teaching methods have been of great importance in the progress of knowledge. Examining the human body is part of the process by which medical students come to understand living forms. However, the need to ...

  6. Understanding the Complexity of Social Issues through Process Drama.

    Science.gov (United States)

    O'Mara, Joanne

    2002-01-01

    Attempts to capture the process of understanding and questioning deforestation through process drama (in which students and teacher work both in and out of role to explore a problem, situation, or theme). Notes that moving topics such as the destruction of a rainforest into process drama introduces complexity into social issues. Considers how…

  7. Understanding complex urban systems integrating multidisciplinary data in urban models

    CERN Document Server

    Gebetsroither-Geringer, Ernst; Atun, Funda; Werner, Liss

    2016-01-01

    This book is devoted to the modeling and understanding of complex urban systems. This second volume of Understanding Complex Urban Systems focuses on the challenges of the modeling tools, concerning, e.g., the quality and quantity of data and the selection of an appropriate modeling approach. It is meant to support urban decision-makers—including municipal politicians, spatial planners, and citizen groups—in choosing an appropriate modeling approach for their particular modeling requirements. The contributors to this volume are from different disciplines, but all share the same goal: optimizing the representation of complex urban systems. They present and discuss a variety of approaches for dealing with data-availability problems and finding appropriate modeling approaches—and not only in terms of computer modeling. The selection of articles featured in this volume reflect a broad variety of new and established modeling approaches such as: - An argument for using Big Data methods in conjunction with Age...

  8. On the wake structure in streaming complex plasmas

    International Nuclear Information System (INIS)

    Ludwig, Patrick; Kählert, Hanno; Bonitz, Michael; Miloch, Wojciech J

    2012-01-01

    The theoretical description of complex (dusty) plasmas requires multiscale concepts that adequately incorporate the correlated interplay of streaming electrons and ions, neutrals and dust grains. Knowing the effective dust-dust interaction, the multiscale problem can be effectively reduced to a one-component plasma model of the dust subsystem. The goal of this paper is a systematic evaluation of the electrostatic potential distribution around a dust grain in the presence of a streaming plasma environment by means of two complementary approaches: (i) a high-precision computation of the dynamically screened Coulomb potential from the dynamic dielectric function and (ii) full 3D particle-in-cell simulations, which self-consistently include dynamical grain charging and nonlinear effects. The range of applicability of these two approaches is addressed. (paper)

  9. Increasing process understanding by analyzing complex interactions in experimental data

    DEFF Research Database (Denmark)

    Naelapaa, Kaisa; Allesø, Morten; Kristensen, Henning Gjelstrup

    2009-01-01

    There is a recognized need for new approaches to understand unit operations with pharmaceutical relevance. A method for analyzing complex interactions in experimental data is introduced. Higher-order interactions do exist between process parameters, which complicate the interpretation...... understanding of a coating process. It was possible to model the response, that is, the amount of drug released, using both mentioned techniques. However, the ANOVAmodel was difficult to interpret as several interactions between process parameters existed. In contrast to ANOVA, GEMANOVA is especially suited...... for modeling complex interactions and making easily understandable models of these. GEMANOVA modeling allowed a simple visualization of the entire experimental space. Furthermore, information was obtained on how relative changes in the settings of process parameters influence the film quality and thereby drug...

  10. Pseudopotentials of the particles interactions in complex plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Ramazanov, T. S.; Moldabekov, Zh. A.; Dzhumagulova, K. N.; Muratov, M. M. [Al Farabi Kazakh National University, IETP, Tole bi 96a, Almaty 050012 (Kazakhstan)

    2011-10-15

    This article discusses the effective interaction potentials in a complex dusty plasma. The interaction of electrons with atoms and the interaction between dusty particles are studied by the method of the dielectric response function. In the effective interaction, potential between electron and atom the quantum effects of diffraction were taken into account. On the curve of the interaction potential between dust particles under certain conditions the oscillations can be observed.

  11. Relationship between the complex susceptibility and the plasma dispersion function

    International Nuclear Information System (INIS)

    Jimenez D, H.; Cabral P, A.

    1991-04-01

    It is shown that when magnetization processes in a spin system and resonant excitation of spin n states occur in the presence of internal and or external random line-broadening mechanisms, the complex magnetic susceptibility of the plasma dispersion function. letter could be useful spin in system is proportional to the relationship found in this spectroscopies such as EPR and NMR, for example, as its fitting to experimental absorption and dispersion profiles produces their Lorentzian and Gaussian contents. (Author)

  12. Relationship between the complex susceptibility and the plasma dispersion function

    Energy Technology Data Exchange (ETDEWEB)

    Jimenez D, H.; Cabral P, A

    1991-04-15

    It is shown that when magnetization processes in a spin system and resonant excitation of spin n states occur in the presence of internal and or external random line-broadening mechanisms, the complex magnetic susceptibility of the plasma dispersion function. letter could be useful spin in system is proportional to the relationship found in this spectroscopies such as EPR and NMR, for example, as its fitting to experimental absorption and dispersion profiles produces their Lorentzian and Gaussian contents. (Author)

  13. Understanding Decision Making through Complexity in Professional Networks

    Directory of Open Access Journals (Sweden)

    Kon Shing Kenneth Chung

    2014-01-01

    Full Text Available The attitudes of general practitioners (GP play an influential role in their decision making about patient treatment and care. Considering the GP-patient encounter as a complex system, the interactions between the GP and their personal network of peers give rise to “aggregate complexity,” which in turn influences the GP’s decisions about patient treatment. This study models aggregate complexity and its influence in decision making in primary care through the use of social network metrics. Professional network and attitudinal data on decision making responsibility from 107 rural GPs were analysed. Social network measures of “density” and “inclusiveness” were used for computing the “interrelatedness” of components within such a “complex system.” The “number of components” and “degree of interrelatedness” were used to determine the complexity profiles, which was then used to associate with responsibility in decision making for each GP. GPs in simple profiles (i.e., with low components and interactions in contrast to those in nonsimple profiles, indicate a higher responsibility for the decisions they make in medical care. This study suggests that social networks-based complexity profiles are useful for understanding decision making in primary care as it accounts for the role of influence through the professional networks of GPs.

  14. Understanding the complex interplay between tourism, disability and environmental contexts.

    Science.gov (United States)

    Packer, Tanya L; McKercher, Bob; Yau, Matthew K

    2007-02-28

    To explore and describe the complex issues and factors related to participation in tourism as perceived by people with disabilities in Hong Kong. Naturalistic inquiry using key informant interviews and focus groups with 86 people with disabilities. Interviews were transcribed, translated and coded to develop themes and relationships. Triangulation of three investigators from different backgrounds occurred. The Process of Becoming Travel Active emerged as a six-stage process, intricately related to the personal/disability context and the environmental/travel context. Personal and environmental factors contribute to the six-stage model explaining the complex interplay between tourism, disability and environmental context. Understanding the complexity provides insight into ways to increase active participation in tourism. Health, tourism and disability sectors have a role to play in the development of accessible tourism.

  15. On the rogue waves propagation in non-Maxwellian complex space plasmas

    Energy Technology Data Exchange (ETDEWEB)

    El-Tantawy, S. A., E-mail: samireltantawy@yahoo.com; El-Awady, E. I., E-mail: eielawady@hotmail.com [Department of Physics, Faculty of Science, Port Said University, Port Said 42521 (Egypt); Tribeche, M., E-mail: mouloudtribeche@yahoo.fr, E-mail: mtribeche@usthb.dz [Plasma Physics Group, Theoretical Physics Laboratory, Faculty of Physics, University of Bab-Ezzouar, USTHB, BP 32, El Alia, Algiers 16111 (Algeria)

    2015-11-15

    The implications of the non-Maxwellian electron distributions (nonthermal/or suprathermal/or nonextensive distributions) are examined on the dust-ion acoustic (DIA) rogue/freak waves in a dusty warm plasma. Using a reductive perturbation technique, the basic set of fluid equations is reduced to a nonlinear Schrödinger equation. The latter is used to study the nonlinear evolution of modulationally unstable DIA wavepackets and to describe the rogue waves (RWs) propagation. Rogue waves are large-amplitude short-lived wave groups, routinely observed in space plasmas. The possible region for the rogue waves to exist is defined precisely for typical parameters of space plasmas. It is shown that the RWs strengthen for decreasing plasma nonthermality and increasing superthermality. For nonextensive electrons, the RWs amplitude exhibits a bit more complex behavior, depending on the entropic index q. Moreover, our numerical results reveal that the RWs exist with all values of the ion-to-electron temperature ratio σ for nonthermal and superthermal distributions and there is no limitation for the freak waves to propagate in both two distributions in the present plasma system. But, for nonextensive electron distribution, the bright- and dark-type waves can propagate in this case, which means that there is a limitation for the existence of freak waves. Our systematic investigation should be useful in understanding the properties of DIA solitary waves that may occur in non-Maxwellian space plasmas.

  16. Computing the complex : Dusty plasmas in the presence of magnetic fields and UV radiation

    Science.gov (United States)

    Land, V.

    2007-12-01

    About 90% of the visible universe is plasma. Interstellar clouds, stellar cores and atmospheres, the Solar wind, the Earth's ionosphere, polar lights, and lightning are all plasma; ionized gases, consisting of electrons, ions, and neutrals. Not only many industries, like the microchip and solar cell industry, but also future fusion power stations, rely heavily on the use of plasma. More and more, home appliances include plasma technologies, like compact fluorescent light sources, and plasma screens. Dust particles, which can disrupt plasma processes, enter these plasmas, through chemical reactions in the plasma, or through interactions between plasma and walls. For instance, during microchip fabrication, dust particles can destroy the tiny, nanometre-sized structures on the surface of these chips. On the other hand, dust particles orbiting Young Stellar Objects coagulate and form the seeds of planets. In order to understand fundamental processes, such as planet formation, or to optimize industrial plasma processes, a thorough description of dusty plasma is necessary. Dust particles immersed in plasma collect ions and electrons from the plasma and charge up electrically. Therefore, the presence of dust changes plasma, while at the same time many forces start acting on the dust. Therefore, the dust and plasma become coupled, making dusty plasma a very complex medium to describe, in which many length and time scales play a role, from the Debye length to the length of the electrodes, and from the inverse plasma frequencies to the dust transport times. Using a self-consistent fluid model, we simulate these multi-scale dusty plasmas in radio frequency discharges under micro-gravity. We show that moderate non-linear scattering of ions by the dust particles is the most important aspect in the calculation of the ion drag force. This force is also responsible for the formation of a dust-free 'void' in dusty plasma under micro-gravity, caused by ions moving from the centre of

  17. Disaster forensics understanding root cause and complex causality

    CERN Document Server

    2016-01-01

    This book aims to uncover the root causes of natural and man-made disasters by going beyond the typical reports and case studies conducted post-disaster. It opens the black box of disasters by presenting ‘forensic analysis approaches’ to disasters, thereby revealing the complex causality that characterizes them and explaining how and why hazards do, or do not, become disasters. This yields ‘systemic’ strategies for managing disasters. Recently the global threat landscape has seen the emergence of high impact, low probability events. Events like Hurricane Katrina, the Great Japan Earthquake and tsunami, Hurricane Sandy, Super Typhoon Haiyan, global terrorist activities have become the new norm. Extreme events challenge our understanding regarding the interdependencies and complexity of the disaster aetiology and are often referred to as Black Swans. Between 2002 and 2011, there were 4130 disasters recorded that resulted from natural hazards around the world. In these, 1,117,527 people perished and a mi...

  18. Complexity and simplification in understanding recruitment in benthic populations

    KAUST Repository

    Pineda, Jesús

    2008-11-13

    Research of complex systems and problems, entities with many dependencies, is often reductionist. The reductionist approach splits systems or problems into different components, and then addresses these components one by one. This approach has been used in the study of recruitment and population dynamics of marine benthic (bottom-dwelling) species. Another approach examines benthic population dynamics by looking at a small set of processes. This approach is statistical or model-oriented. Simplified approaches identify "macroecological" patterns or attempt to identify and model the essential, "first-order" elements of the system. The complexity of the recruitment and population dynamics problems stems from the number of processes that can potentially influence benthic populations, including (1) larval pool dynamics, (2) larval transport, (3) settlement, and (4) post-settlement biotic and abiotic processes, and larval production. Moreover, these processes are non-linear, some interact, and they may operate on disparate scales. This contribution discusses reductionist and simplified approaches to study benthic recruitment and population dynamics of bottom-dwelling marine invertebrates. We first address complexity in two processes known to influence recruitment, larval transport, and post-settlement survival to reproduction, and discuss the difficulty in understanding recruitment by looking at relevant processes individually and in isolation. We then address the simplified approach, which reduces the number of processes and makes the problem manageable. We discuss how simplifications and "broad-brush first-order approaches" may muddle our understanding of recruitment. Lack of empirical determination of the fundamental processes often results in mistaken inferences, and processes and parameters used in some models can bias our view of processes influencing recruitment. We conclude with a discussion on how to reconcile complex and simplified approaches. Although it

  19. "Understanding Adam" multiple reciprocal translocations: complex case presentation.

    Science.gov (United States)

    Linder, Carie E; Lu, Xianglan; Kim, Young Mi; Li, Shibo; Pineda, Jose

    2009-01-01

    This article presents a case review of a newborn diagnosed with a complex chromosomal rearrangement, as demonstrated through a painted chromosomal analysis. This infant presented with multiple dysmorphology including cutis aplasia, multiple ocular malformations, bilateral cleft lip and palate, and postnatal hydrocephaly. A chromosomal analysis revealed multiple-ways, balanced translocation involving chromosomes 3, 4, 6, 8, and 9. This case study provides a unique opportunity to, in retrospect, trace each malformation exploring the pathophysiology, etiology, and correlating origin with chromosomal variation. Careful review of this case, enhanced by the visually augmented representation of each translocation, will increase understanding of chromosomal anomalies and their implications in embryological development and clinical presentation.

  20. Understanding Parkinson Disease: A Complex and Multifaceted Illness.

    Science.gov (United States)

    Gopalakrishna, Apoorva; Alexander, Sheila A

    2015-12-01

    Parkinson disease is an incredibly complex and multifaceted illness affecting millions of people in the United States. Parkinson disease is characterized by progressive dopaminergic neuronal dysfunction and loss, leading to debilitating motor, cognitive, and behavioral symptoms. Parkinson disease is an enigmatic illness that is still extensively researched today to search for a better understanding of the disease, develop therapeutic interventions to halt or slow progression of the disease, and optimize patient outcomes. This article aims to examine in detail the normal function of the basal ganglia and dopaminergic neurons in the central nervous system, the etiology and pathophysiology of Parkinson disease, related signs and symptoms, current treatment, and finally, the profound impact of understanding the disease on nursing care.

  1. Recent developments in understanding the physics of laser produced plasmas

    International Nuclear Information System (INIS)

    Bezzerides, B.; DuBois, D.F.; Forslund, D.W.; Kindel, J.M.; Lee, K.; Lindman, E.L.

    1976-01-01

    The absorption of intense laser light by a plasma is known to produce a high energy component of electrons. Even though the hot electron pressure may be larger than the cold background pressure, the background temperature can control the self-consistent profile modification. Since temperatures in high intensity experiments seem to be similar for CO 2 and Nd glass lasers, the profile modification may be so severe for CO 2 and Nd glass lasers, the profile modification may be so severe for CO 2 that orders of magnitude change in density can occur over microns, leading to a softened electron spectrum. However, the resulting equilibrium of laser pressure balancing plasma pressure is unstable even when flow is properly taken into account. We also briefly discuss recent results for self-generated magnetic fields including important kinetic effects

  2. Using the tools of the trade to understand plasma interactions at Jupiter and Saturn

    Science.gov (United States)

    Kivelson, Margaret G.

    2017-10-01

    For more than half a century, we have been learning how magnetospheres work. Fluid motions and electromagnetic interactions combine to produce the plasma and field environment of a planet. Kinetic responses often control the dynamics. Initial descriptions of the terrestrial magnetosphere were often theoretical (e.g., Chapman and Ferraro, Dungey) before an explosion of spacecraft data provided an atlas of the system and its temporal variations. The basic structure and dynamics of the terrestrial magnetosphere are now largely understood. A different situation exists for the magnetospheres of Jupiter, Saturn, and their moons. Data acquired from spacecraft flybys or from orbit have characterized many aspects of these systems, but measurements are far more limited than at Earth both in space and in time. Even after Cassini’s mission to Saturn and Juno’s prime mission at Jupiter have ended, large regions in the plasma environments of these planets will remain unexplored. No monitors are available to characterize the upstream solar wind. Theory is challenged by the complexity introduced by dynamical effects of the planets’ rapid rotation and the unfamiliar parameter regimes governing interactions with their large moons. Simulation has come to the rescue, providing computational models designed to incorporate the effects of rotation or to describe moon-magnetosphere interactions. Yet simulations must be viewed with appropriate skepticism as they invariably require some compromise with reality. This talk will describe a symbiotic approach to understanding the dynamics of giant planet magnetospheres and the plasma interactions between magnetospheric plasma and large moons. Data acquired along a spacecraft trajectory are compared with values extracted from a virtual spacecraft moving through the same path in the simulation. If results are similar, we use the simulation to identify the processes responsible for puzzling aspects of the signatures. If results differ

  3. Land, power and conflict in Afghanistan: seeking to understand complexity

    Directory of Open Access Journals (Sweden)

    Adam Pain

    2013-06-01

    Full Text Available This paper explores the diverse links between land and power under conditions of conflict in Afghanistan, taking into account the complexities of Afghan society. These complexities are structured around interconnecting informal institutions and personalised relationships, culturally specific, diverse and shifting patterns of social relations, and spatially specific patterns of land ownership inequalities. The paper draws on a decade of empirical fieldwork in Afghanistan and recent work on livelihood trajectories and the opium economy. An understanding of the evolution of land ownership and access issues needs to be associated with an appreciation of diverse and potentially contradictory long-term drivers of change in the rural economy. The first of these long-term drivers of change relates to the effects of conflict, not only on land but also of water access under conditions of an increasingly scarce water supply. The second driver relates both to the roles played by village elites and to the structural contrasts between villages located in the mountains and in the plains, with the latter displaying major inequalities in land ownership. The third driver relates to the declining economic role of land in rural livelihoods, given long-term agrarian change and falling farm sizes. An understanding of history is fundamental to explaining these phenomena. How such conflicts play out, and which social groups or individuals they involve, also depend to a large degree on spatial positioning.

  4. Complex plasma experimental device–A test bed for studying dust ...

    Indian Academy of Sciences (India)

    A typical device for carrying out sophisticated and complex dusty plasma experiments is designed, fabricated and made operational at the Institute for Plasma Research, India. The device is named as complex plasma experimental device (CPED). The main aim of this multipurpose machine is to study the formation and ...

  5. Understanding CMEs using plasma diagnostics of the related dimmings

    Science.gov (United States)

    Vanninathan, Kamalam; Veronig, Astrid; Gomory, Peter; Dissauer, Karin; Temmer, Manuela; Hannah, Iain; Kontar, Eduard

    2017-04-01

    Coronal Mass Ejections (CMEs) are often associated with dimmings that are well observed in Extreme Ultra-violet (EUV) wavelengths. Such dimmings are suggested to represent the evacuation of mass that is carried out by CMEs and are a unique and indirect means to study CME properties. While Earth-directed CMEs (on-disk CMEs) are difficult to observe due to the bright background solar disk and projection effects, their corresponding dimmings are clearly discernible and ideally suited for analysis. Using data from the 6 EUV channels of Solar Dynamics Observatory/Atmospheric Imaging Assembly for Differential Emission Measure (DEM) diagnostics, we determine the plasma characteristics of the dimming region. These data are well suited for this kind of study due to the good temperature ranges covered by the multiple passbands of the instrument. We analyse 7 on-disk and 5 off-limb events and derive the weighted density and temperature as a function of time, from the DEMs. From such an analysis we differentiate 2 types of dimming regions: core and secondary dimmings. Core dimmings often occur in pairs lying on either sides of the active region and in opposite polarity regions while the secondary dimming is more extended. In both the regions the derived plasma parameters reach a minimum within 30-60 min after the flare. For each event the core dimming region shows a higher decrease in density and temperature than the corresponding secondary dimming regions. The values of these parameters remains low within the core dimming region for the entire duration of this study ( 10 hrs after the flare) while the secondary dimming region starts to show a gradual increase after 1-2 hrs. We also use spectroscopic data from Hinode/Extreme-Ultraviolet Imaging Spectrometer to differentiate core and secondary dimming regions. We find that the Fe XIII 202 Å line shows double component profiles within the core dimming region with strong blueshifts of 100 km/s while the secondary dimming region

  6. Evolution in students’ understanding of thermal physics with increasing complexity

    Directory of Open Access Journals (Sweden)

    Elon Langbeheim

    2013-11-01

    Full Text Available We analyze the development in students’ understanding of fundamental principles in the context of learning a current interdisciplinary research topic—soft matter—that was adapted to the level of high school students. The topic was introduced in a program for interested 11th grade high school students majoring in chemistry and/or physics, in an off-school setting. Soft matter was presented in a gradual increase in the degree of complexity of the phenomena as well as in the level of the quantitative analysis. We describe the evolution in students’ use of fundamental thermodynamics principles to reason about phase separation—a phenomenon that is ubiquitous in soft matter. In particular, we examine the impact of the use of free energy analysis, a common approach in soft matter, on the understanding of the fundamental principles of thermodynamics. The study used diagnostic questions and classroom observations to gauge the student’s learning. In order to gain insight on the aspects that shape the understanding of the basic principles, we focus on the responses and explanations of two case-study students who represent two trends of evolution in conceptual understanding in the group. We analyze changes in the two case studies’ management of conceptual resources used in their analysis of phase separation, and suggest how their prior knowledge and epistemological framing (a combination of their personal tendencies and their prior exposure to different learning styles affect their conceptual evolution. Finally, we propose strategies to improve the instruction of these concepts.

  7. Neuroanthropological Understanding of Complex Cognition – Numerosity and Arithmetics

    Directory of Open Access Journals (Sweden)

    Zarja Mursic

    2013-10-01

    Full Text Available Humankind has a long evolutionary history. When we are trying to understand human complex cognition, it is as well important to look back to entire evolution. I will present the thesis that our biological predispositions and culture, together with natural and social environment, are tightly connected. During ontogenetically development we are shaped by various factors, and they enabled humans to develop some aspects of complex cognition, such as mathematics.In the beginning of the article I present the importance of natural and cultural evolution in other animals. In the following part, I briefly examine the field of mathematics – numerosity and arithmetic. Presentation of comparative animal studies, mainly made on primates, provides some interesting examples in animals’ abilities to separate between different quantities. From abilities for numerosity in animals I continue to neuroscientific studies of humans and our ability to solve simple arithmetic tasks. I also mention cross-cultural studies of arithmetic skills. In the final part of the text I present the field neuroanthropology as a possible new pillar of cognitive science. Finally, it is important to connect human evolution and development with animal cognition studies, but as well with cross-cultural studies in shaping of human ability for numerosity and arithmetic.

  8. Understanding and measuring quality of care: dealing with complexity.

    Science.gov (United States)

    Hanefeld, Johanna; Powell-Jackson, Timothy; Balabanova, Dina

    2017-05-01

    Existing definitions and measurement approaches of quality of health care often fail to address the complexities involved in understanding quality of care. It is perceptions of quality, rather than clinical indicators of quality, that drive service utilization and are essential to increasing demand. Here we reflect on the nature of quality, how perceptions of quality influence health systems and what such perceptions indicate about measurement of quality within health systems. We discuss six specific challenges related to the conceptualization and measurement of the quality of care: perceived quality as a driver of service utilization; quality as a concept shaped over time through experience; responsiveness as a key attribute of quality; the role of management and other so-called upstream factors; quality as a social construct co-produced by families, individuals, networks and providers; and the implications of our observations for measurement. Within the communities and societies where care is provided, quality of care cannot be understood outside social norms, relationships, trust and values. We need to improve not only technical quality but also acceptability, responsiveness and levels of patient-provider trust. Measurement approaches need to be reconsidered. An improved understanding of all the attributes of quality in health systems and their interrelationships could support the expansion of access to essential health interventions.

  9. Understanding complexity in neurodegenerative diseases: in silico reconstruction of emergence

    Directory of Open Access Journals (Sweden)

    Alexey eKolodkin

    2012-07-01

    Full Text Available Healthy functioning is an emergent property of the network of interacting biomolecules that comprise an organism. It follows that disease (a network shift that causes malfunction is also an emergent property, emerging from a perturbation of the network. On one hand, the biomolecular network of every individual is unique and this is evident when similar disease-producing agents cause different individual pathologies. Consequently, a personalized model and approach for every patient may be required for therapies to become effective across mankind. On the other hand, diverse combinations of internal and external perturbation factors may cause a similar shift in network functioning. We offer this as an explanation for the multi-factorial nature of most diseases: they are ‘systems biology diseases’, or ‘network diseases’. Here we focus on neurodegenerative diseases, like Parkinson’s disease, as an example. Because of the inherent complexity of these networks, it is difficult to understand multi-factorial diseases using simply our ‘naked brain’. When describing interactions between biomolecules through mathematical equations and integrating those equations into a mathematical model, we try to reconstruct the emergent properties of the system in silico. The reconstruction of emergence from interactions between huge numbers of macromolecules is one of the aims of systems biology. Systems biology approaches enable us to break through the limitation of the human brain to perceive the extraordinarily large number of interactions, but this also means that we delegate the understanding of reality to the computer. We no longer recognize all those essences in the system’s design crucial for important physiological behavior (the so-called ‘design principles’ of the system. In this paper we review evidence that by using more abstract approaches and by experimenting in silico, one may still be able to discover and understand the design

  10. Advancing the understanding of plasma transport in mid-size stellarators

    Science.gov (United States)

    Hidalgo, Carlos; Talmadge, Joseph; Ramisch, Mirko; TJ-II, the; HXS; TJ-K Teams

    2017-01-01

    The tokamak and the stellarator are the two main candidate concepts for magnetically confining fusion plasmas. The flexibility of the mid-size stellarator devices together with their unique diagnostic capabilities make them ideally suited to study the relation between magnetic topology, electric fields and transport. This paper addresses advances in the understanding of plasma transport in mid-size stellarators with an emphasis on the physics of flows, transport control, impurity and particle transport and fast particles. The results described here emphasize an improved physics understanding of phenomena in stellarators that complements the empirical approach. Experiments in mid-size stellarators support the development of advanced plasma scenarios in Wendelstein 7-X (W7-X) and, in concert with better physics understanding in tokamaks, may ultimately lead to an advance in the prediction of burning plasma behaviour.

  11. Cold atmospheric-pressure plasma and bacteria: understanding the mode of action using vibrational microspectroscopy

    International Nuclear Information System (INIS)

    Kartaschew, Konstantin; Mischo, Meike; Bründermann, Erik; Havenith, Martina; Baldus, Sabrina; Awakowicz, Peter

    2016-01-01

    Cold atmospheric-pressure plasma show promising antimicrobial effects, however the detailed biochemical mechanism of the bacterial inactivation is still unknown. We investigated, for the first time, plasma-treated Gram-positive Bacillus subtilis and Gram-negative Escherichia coli bacteria with Raman and infrared microspectroscopy. A dielectric barrier discharge was used as a plasma source. We were able to detect several plasma-induced chemical modifications, which suggest a pronounced oxidative effect on the cell envelope, cellular proteins and nucleotides as well as a generation of organic nitrates in the treated bacteria. Vibrational microspectroscopy is used as a comprehensive and a powerful tool for the analysis of plasma interactions with whole organisms such as bacteria. Analysis of reaction kinetics of chemical modifications allow a time-dependent insight into the plasma-mediated impact. Investigating possible synergistic effects between the plasma-produced components, our observations strongly indicate that the detected plasma-mediated chemical alterations can be mainly explained by the particle effect of the generated reactive species. By changing the polarity of the applied voltage pulse, and hence the propagation mechanisms of streamers, no significant effect on the spectral results could be detected. This method allows the analysis of the individual impact of each plasma constituent for particular chemical modifications. Our approach shows great potential to contribute to a better understanding of plasma-cell interactions. (paper)

  12. Understanding and controlling complex states arising from magnetic frustration

    Energy Technology Data Exchange (ETDEWEB)

    Zapf, Vivien [Los Alamos National Laboratory

    2012-06-01

    Much of our national security relies on capabilities made possible by magnetism, in particular the ability to compute and store huge bodies of information as well as to move things and sense the world. Most of these technologies exploit ferromagnetism, i.e. the global parallel alignment of magnetic spins as seen in a bar magnet. Recent advances in computing technologies, such as spintronics and MRAM, take advantage of antiferromagnetism where the magnetic spins alternate from one to the next. In certain crystal structures, however, the spins take on even more complex arrangements. These are often created by frustration, where the interactions between spins cannot be satisfied locally or globally within the material resulting in complex and often non-coplanar spin textures. Frustration also leads to the close proximity of many different magnetic states, which can be selected by small perturbations in parameters like magnetic fields, temperature and pressure. It is this tunability that makes frustrated systems fundamentally interesting and highly desirable for applications. We move beyond frustration in insulators to itinerant systems where the interaction between mobile electrons and the non-coplanar magnetic states lead to quantum magneto-electric amplification. Here a small external field is amplified by many orders of magnitude by non-coplanar frustrated states. This greatly enhances their sensitivity and opens broader fields for applications. Our objective is to pioneer a new direction for condensed matter science at the Laboratory as well as for international community by discovering, understanding and controlling states that emerge from the coupling of itinerant charges to frustrated spin textures.

  13. Isolation of Synaptosomes, Synaptic Plasma Membranes, and Synaptic Junctional Complexes.

    Science.gov (United States)

    Michaelis, Mary L; Jiang, Lei; Michaelis, Elias K

    2017-01-01

    Isolation of synaptic nerve terminals or synaptosomes provides an opportunity to study the process of neurotransmission at many levels and with a variety of approaches. For example, structural features of the synaptic terminals and the organelles within them, such as synaptic vesicles and mitochondria, have been elucidated with electron microscopy. The postsynaptic membranes are joined to the presynaptic "active zone" of transmitter release through cell adhesion molecules and remain attached throughout the isolation of synaptosomes. These "post synaptic densities" or "PSDs" contain the receptors for the transmitters released from the nerve terminals and can easily be seen with electron microscopy. Biochemical and cell biological studies with synaptosomes have revealed which proteins and lipids are most actively involved in synaptic release of neurotransmitters. The functional properties of the nerve terminals, such as responses to depolarization and the uptake or release of signaling molecules, have also been characterized through the use of fluorescent dyes, tagged transmitters, and transporter substrates. In addition, isolated synaptosomes can serve as the starting material for the isolation of relatively pure synaptic plasma membranes (SPMs) that are devoid of organelles from the internal environment of the nerve terminal, such as mitochondria and synaptic vesicles. The isolated SPMs can reseal and form vesicular structures in which transport of ions such as sodium and calcium, as well as solutes such as neurotransmitters can be studied. The PSDs also remain associated with the presynaptic membranes during isolation of SPM fractions, making it possible to isolate the synaptic junctional complexes (SJCs) devoid of the rest of the plasma membranes of the nerve terminals and postsynaptic membrane components. Isolated SJCs can be used to identify the proteins that constitute this highly specialized region of neurons. In this chapter, we describe the steps involved

  14. Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

    OpenAIRE

    Yuetiva Deming; Jian Xia; Yefei Cai; Jenny Lord; Jorge L. Del-Aguila; Maria Victoria Fernandez; David Carrell; Kathleen Black; John Budde; ShengMei Ma; Benjamin Saef; Bill Howells; Sarah Bertelsen; Matthew Bailey; Perry G. Ridge

    2016-01-01

    Genome-wide association studies of 146 plasma protein levels in 818 individuals revealed 56 genome-wide significant associations (28 novel) with 47 analytes. Loci associated with plasma levels of 39 proteins tested have been previously associated with various complex traits such as heart disease, inflammatory bowel disease, Type 2 diabetes, and multiple sclerosis. These data suggest that these plasma protein levels may constitute informative endophenotypes for these complex traits. We found t...

  15. Statistical mechanics of the distribution of charge on particles in complex plasmas

    International Nuclear Information System (INIS)

    Sodha, M S; Mishra, S K; Misra, Shikha

    2011-01-01

    This paper presents an analytical study of the distribution of charge on the particles in a complex plasma; the study is based on statistical mechanics and ensures that the charge on the particles is an integral multiple of the electronic charge. The formulation incorporates both the number and energy balance of electrons/ions. Three specific cases of charging of particles have been considered, namely (i) in a plasma in the absence of electron emission from the particles, (ii) in a complex plasma in thermal equilibrium and (iii) in a complex plasma irradiated by monochromatic radiation, causing photoelectric emission of electrons from the particles. The effect of various parameters on the charge distribution has also been investigated. This paper is in reasonably good agreement with the fluctuation theory for large values of Z (Ze is the charge on a particle). It is seen that under certain conditions, a significant number of oppositely charged particles occur in the complex plasma.

  16. An attempt to understand kidney's protein handling function by comparing plasma and urine proteomes.

    Directory of Open Access Journals (Sweden)

    Lulu Jia

    Full Text Available BACKGROUND: With the help of proteomics technology, the human plasma and urine proteomes, which closely represent the protein compositions of the input and output of the kidney, respectively, have been profiled in much greater detail by different research teams. Many datasets have been accumulated to form "reference profiles" of the plasma and urine proteomes. Comparing these two proteomes may help us understand the protein handling aspect of kidney function in a way, however, which has been unavailable until the recent advances in proteomics technology. METHODOLOGY/PRINCIPAL FINDINGS: After removing secreted proteins downstream of the kidney, 2611 proteins in plasma and 1522 in urine were identified with high confidence and compared based on available proteomic data to generate three subproteomes, the plasma-only subproteome, the plasma-and-urine subproteome, and the urine-only subproteome, and they correspond to three groups of proteins that are handled in three different ways by the kidney. The available experimental molecular weights of the proteins in the three subproteomes were collected and analyzed. Since the functions of the overrepresented proteins in the plasma-and-urine subproteome are probably the major functions that can be routinely regulated by excretion from the kidney in physiological conditions, Gene Ontology term enrichment in the plasma-and-urine subproteome versus the whole plasma proteome was analyzed. Protease activity, calcium and growth factor binding proteins, and coagulation and immune response-related proteins were found to be enriched. CONCLUSION/SIGNIFICANCE: The comparison method described in this paper provides an illustration of a new approach for studying organ functions with a proteomics methodology. Because of its distinctive input (plasma and output (urine, it is reasonable to predict that the kidney will be the first organ whose functions are further elucidated by proteomic methods in the near future. It

  17. Understanding the anomalous dispersion of doubly-ionized carbon plasmas near 47 nm

    Energy Technology Data Exchange (ETDEWEB)

    Nilsen, J; Castor, J I; Iglesias, C A; Cheng, K T; Dunn, J; Johnson, W R; Filevich, J; Purvis, M A; Grava, J; Rocca, J J

    2008-04-15

    Over the last several years we have predicted and observed plasmas with an index of refraction greater than one in the soft X-ray regime. These plasmas are usually a few times ionized and have ranged from low-Z carbon plasmas to mid-Z tin plasmas. Our main calculational tool has been the average atom code. We have recently observed C{sup 2+} plasmas with an index of refraction greater than one at a wavelength of 46.9 nm (26.44 eV). In this paper we compare the average atom method, AVATOMKG, against two more detailed methods, OPAL and CAK, for calculating the index of refraction for the carbon plasmas and discuss the different approximations used. We present experimental measurements of carbon plasmas that display this anomalous dispersion phenomenon. It is shown that the average atom calculation is a good approximation when the strongest lines dominate the dispersion. However, when weaker lines make a significant contribution, the more detailed calculations such as OPAL and CAK are essential. During the next decade X-ray free electron lasers and other X-ray sources will be available to probe a wider variety of plasmas at higher densities and shorter wavelengths so understanding the index of refraction in plasmas will be even more essential. With the advent of tunable X-ray lasers the frequency dependent interferometer measurements of the index of refraction may enable us to determine the absorption coefficients and line-shapes and make detailed comparisons against our atomic physics codes.

  18. Understanding global health governance as a complex adaptive system.

    Science.gov (United States)

    Hill, Peter S

    2011-01-01

    The transition from international to global health reflects the rapid growth in the numbers and nature of stakeholders in health, as well as the constant change embodied in the process of globalisation itself. This paper argues that global health governance shares the characteristics of complex adaptive systems, with its multiple and diverse players, and their polyvalent and constantly evolving relationships, and rich and dynamic interactions. The sheer quantum of initiatives, the multiple networks through which stakeholders (re)configure their influence, the range of contexts in which development for health is played out - all compound the complexity of this system. This paper maps out the characteristics of complex adaptive systems as they apply to global health governance, linking them to developments in the past two decades, and the multiple responses to these changes. Examining global health governance through the frame of complexity theory offers insight into the current dynamics of governance, and while providing a framework for making meaning of the whole, opens up ways of accessing this complexity through local points of engagement.

  19. Understanding sustainability from an exergetic frame in complex adaptive systems

    International Nuclear Information System (INIS)

    Aguilar Hernandez, Glem Alonso

    2017-01-01

    The concept of sustainability was developed from thermodynamic properties applied to complex adaptive systems. The origins of the perception about sustainable development and limitation in its application to analyze the interaction between a system and its surroundings were described. The properties of a complex adaptive system were taken as basis to determine how a system can to be affected by the resources restriction and irreversibility of the processes. The complex adaptive system was understood using the first and second law of thermodynamics, generating a conceptual framework to define the sustainability of a system. The contributions developed by exergy were shown to analyze the sustainability of systems in an economic, social and environmental context [es

  20. Understanding dyadic promoter-stakeholder relations in complex projects

    Directory of Open Access Journals (Sweden)

    Janita Vos

    2016-01-01

    Full Text Available In this study, we propose a Bilateral Double Motive framework of stakeholder cooperation in complex projects. The framework analyses and explains dyadic promoter-stakeholder relationships at a micro level by acknowledging both transactional and relational motives. We demonstrate the framework’s usefulness by illustrating its explanatory power in two instances of cooperation and two of non-cooperation within two health information technology projects. The study contributes to project management theory through its combined focus on transactional and relational motives. Further, the study contributes to practice by providing a tool for planning and evaluating cooperation in health Information Technology projects and similar complex multi-stakeholder environments.

  1. Breathing-mode resonance of a complex plasma disk

    International Nuclear Information System (INIS)

    Sheridan, T.E.; Buckey, C.R.; Cox, D.J.; Merrill, R.J.; Theisen, W.L.

    2004-01-01

    We have experimentally characterized the breathing mode oscillation of a strongly-coupled, dusty plasma disk. Steady-state oscillations are excited by sinusoidally modulating the plasma density, creating a single-frequency, in-plane driving force. Resonance curves agree well with damped harmonic oscillator theory. A response at the second harmonic is observed and found to increase with the square of the driving force, indicating a quadratic nonlinearity

  2. Uncertainty and error in complex plasma chemistry models

    Science.gov (United States)

    Turner, Miles M.

    2015-06-01

    Chemistry models that include dozens of species and hundreds to thousands of reactions are common in low-temperature plasma physics. The rate constants used in such models are uncertain, because they are obtained from some combination of experiments and approximate theories. Since the predictions of these models are a function of the rate constants, these predictions must also be uncertain. However, systematic investigations of the influence of uncertain rate constants on model predictions are rare to non-existent. In this work we examine a particular chemistry model, for helium-oxygen plasmas. This chemistry is of topical interest because of its relevance to biomedical applications of atmospheric pressure plasmas. We trace the primary sources for every rate constant in the model, and hence associate an error bar (or equivalently, an uncertainty) with each. We then use a Monte Carlo procedure to quantify the uncertainty in predicted plasma species densities caused by the uncertainty in the rate constants. Under the conditions investigated, the range of uncertainty in most species densities is a factor of two to five. However, the uncertainty can vary strongly for different species, over time, and with other plasma conditions. There are extreme (pathological) cases where the uncertainty is more than a factor of ten. One should therefore be cautious in drawing any conclusion from plasma chemistry modelling, without first ensuring that the conclusion in question survives an examination of the related uncertainty.

  3. Matrix Models – An Approach to Understand Complex Systems

    Indian Academy of Sciences (India)

    Matrices with random matrix elements appear to have applications in physics, mathematics, bi- ology, telecommunications, etc. In fact, experi- mental data of many complex systems, such as the spacing distribution of energy level spectra of heavy nuclei, and the distribution of the non- real zeros of the Riemann zeta function ...

  4. Understanding dyadic promoter-stakeholder relations in complex projects

    NARCIS (Netherlands)

    Vos, Janita F.J.; Boonstra, Albert; Achterkamp, Marjolein C.

    2016-01-01

    In this study, we propose a Bilateral Double Motive framework of stakeholder cooperation in complex projects. The framework analyses and explains dyadic promoter-stakeholder relationships at a micro level by acknowledging both transactional and relational motives. We demonstrate the framework’s

  5. Post-cardiac arrest level of free-plasma DNA and DNA-histone complexes

    DEFF Research Database (Denmark)

    Jeppesen, A N; Hvas, A-M; Grejs, A M

    2017-01-01

    Background Plasma DNA-histone complexes and total free-plasma DNA have the potential to quantify the ischaemia-reperfusion damages occurring after cardiac arrest. Furthermore, DNA-histone complexes may have the potential of being a target for future treatment. The aim was to examine if plasma DNA-histone...... after 22, 46 and 70 h. Samples for DNA-histone complexes were quantified by Cell Death Detection ELISAplus. The total free-plasma DNA analyses were quantified with qPCR by analysing the Beta-2 microglobulin gene. The control group comprised 40 healthy individuals. Results We found no difference...... in the level of DNA-histone complexes between the 22-h sample and healthy individuals (P = 0.10). In the 46-h sample, there was an increased level of DNA-histone complexes in non-survivors compared with survivors 30 days after the cardiac arrest (P

  6. Changes in plasma cytokines and their soluble receptors in complex regional pain syndrome.

    Science.gov (United States)

    Alexander, Guillermo M; Peterlin, B Lee; Perreault, Marielle J; Grothusen, John R; Schwartzman, Robert J

    2012-01-01

    Complex Regional Pain Syndrome (CRPS) is a chronic and often disabling pain disorder. There is evidence demonstrating that neurogenic inflammation and activation of the immune system play a significant role in the pathophysiology of CRPS. This study evaluated the plasma levels of cytokines, chemokines, and their soluble receptors in 148 subjects afflicted with CRPS and in 60 gender- and age-matched healthy controls. Significant changes in plasma cytokines, chemokines, and their soluble receptors were found in subjects with CRPS as compared with healthy controls. For most analytes, these changes resulted from a distinct subset of the CRPS subjects. When the plasma data from the CRPS subjects was subjected to cluster analysis, it revealed 2 clusters within the CRPS population. The category identified as most important for cluster separation by the clustering algorithm was TNFα. Cluster 1 consisted of 64% of CRPS subjects and demonstrated analyte values similar to the healthy control individuals. Cluster 2 consisted of 36% of the CRPS subjects and demonstrated significantly elevated levels of most analytes and in addition, it showed that the increased plasma analyte levels in this cluster were correlated with disease duration and severity. The identification of biomarkers that define disease subgroups can be of great value in the design of specific therapies and of great benefit to the design of clinical trials. It may also aid in advancing our understanding of the mechanisms involved in the pathophysiology of CRPS, which may lead to novel treatments for this very severe condition. Copyright © 2012 American Pain Society. Published by Elsevier Inc. All rights reserved.

  7. How Information Visualization Systems Change Users' Understandings of Complex Data

    Science.gov (United States)

    Allendoerfer, Kenneth Robert

    2009-01-01

    User-centered evaluations of information systems often focus on the usability of the system rather its usefulness. This study examined how a using an interactive knowledge-domain visualization (KDV) system affected users' understanding of a domain. Interactive KDVs allow users to create graphical representations of domains that depict important…

  8. Fusion in computer vision understanding complex visual content

    CERN Document Server

    Ionescu, Bogdan; Piatrik, Tomas

    2014-01-01

    This book presents a thorough overview of fusion in computer vision, from an interdisciplinary and multi-application viewpoint, describing successful approaches, evaluated in the context of international benchmarks that model realistic use cases. Features: examines late fusion approaches for concept recognition in images and videos; describes the interpretation of visual content by incorporating models of the human visual system with content understanding methods; investigates the fusion of multi-modal features of different semantic levels, as well as results of semantic concept detections, fo

  9. Using chemistry and microfluidics to understand the spatial dynamics of complex biological networks.

    Science.gov (United States)

    Kastrup, Christian J; Runyon, Matthew K; Lucchetta, Elena M; Price, Jessica M; Ismagilov, Rustem F

    2008-04-01

    predict the dynamics of initiation and propagation of blood clotting and tested these predictions with human blood plasma by using microfluidics. We discovered that both initiation and propagation of clotting are regulated by a threshold response to the concentration of activators of clotting, and that clotting is sensitive to the spatial localization of stimuli. To understand the dynamics of patterning of the Drosophila embryo, we used microfluidics to perturb the environment around a developing embryo and observe the effects of this perturbation on the expression of Hunchback, a protein whose localization is essential to proper development. We found that the mechanism that is responsible for Hunchback positioning is asymmetric, time-dependent, and more complex than previously proposed by studies of individual reactions. Overall, these approaches provide strategies for simplifying, modeling, and probing complex networks without sacrificing the functionality of the network. Such network-level strategies may be most useful for understanding systems with nonlinear interactions where spatial dynamics is essential for function. In addition, microfluidics provides an opportunity to investigate the mechanisms responsible for robust functioning of complex networks. By creating nonideal, stressful, and perturbed environments, microfluidic experiments could reveal the function of pathways thought to be nonessential under ideal conditions.

  10. Application of tomographic particle image velocimetry to complex (dusty) plasmas

    International Nuclear Information System (INIS)

    Williams, Jeremiah

    2011-01-01

    Over the past decade, particle image velocimetry (PIV) techniques have been used to obtain detailed measurements of the thermal and transport properties of weakly-coupled dusty plasmas. This paper reports on the application of an extension of these techniques, tomographic PIV (tom-PIV), which provides an instantaneous volumetric measurement of the particle transport.

  11. Understanding the Complex Patterns Observed during Hepatitis B Virus Therapy.

    Science.gov (United States)

    Carracedo Rodriguez, Andrea; Chung, Matthias; Ciupe, Stanca M

    2017-05-19

    Data from human clinical trials have shown that the hepatitis B virus (HBV) follows complex profiles, such as bi-phasic, tri-phasic, stepwise decay and rebound. We utilized a deterministic model of HBV kinetics following antiviral therapy to uncover the mechanistic interactions behind HBV dynamics. Analytical investigation of the model was used to separate the parameter space describing virus decay and rebound. Monte Carlo sampling of the parameter space was used to determine the virological, pharmacological and immunological factors that separate the bi-phasic and tri-phasic virus profiles. We found that the level of liver infection at the start of therapy best separates the decay patterns. Moreover, drug efficacy, ratio between division of uninfected and infected cells, and the strength of cytotoxic immune response are important in assessing the amount of liver damage experienced over time and in quantifying the duration of therapy leading to virus resolution in each of the observed profiles.

  12. Quantifying 'causality' in complex systems: understanding transfer entropy.

    Directory of Open Access Journals (Sweden)

    Fatimah Abdul Razak

    Full Text Available 'Causal' direction is of great importance when dealing with complex systems. Often big volumes of data in the form of time series are available and it is important to develop methods that can inform about possible causal connections between the different observables. Here we investigate the ability of the Transfer Entropy measure to identify causal relations embedded in emergent coherent correlations. We do this by firstly applying Transfer Entropy to an amended Ising model. In addition we use a simple Random Transition model to test the reliability of Transfer Entropy as a measure of 'causal' direction in the presence of stochastic fluctuations. In particular we systematically study the effect of the finite size of data sets.

  13. Quantifying ‘Causality’ in Complex Systems: Understanding Transfer Entropy

    Science.gov (United States)

    Abdul Razak, Fatimah; Jensen, Henrik Jeldtoft

    2014-01-01

    ‘Causal’ direction is of great importance when dealing with complex systems. Often big volumes of data in the form of time series are available and it is important to develop methods that can inform about possible causal connections between the different observables. Here we investigate the ability of the Transfer Entropy measure to identify causal relations embedded in emergent coherent correlations. We do this by firstly applying Transfer Entropy to an amended Ising model. In addition we use a simple Random Transition model to test the reliability of Transfer Entropy as a measure of ‘causal’ direction in the presence of stochastic fluctuations. In particular we systematically study the effect of the finite size of data sets. PMID:24955766

  14. Understanding Complex Human Ecosystems: The Case of Ecotourism on Bonaire

    Directory of Open Access Journals (Sweden)

    Thomas Abel

    2003-12-01

    Full Text Available It is suggested that ecotourism development on the island of Bonaire can be productively understood as a perturbation of a complex human ecosystem. Inputs associated with ecotourism have fueled transformations of the island ecology and sociocultural system. The results of this study indicate that Bonaire's social and economic hierarchy is approaching a new, stable systems state following a 50-yr transition begun by government and industry that stabilized with the appearance of ecotourism development and population growth. Ecotourism can be understood to have "filled in" the middle of the production hierarchy of Bonaire. Interpreted from this perspective, population growth has completed the transformation by expanding into production niches at smaller scales in the production hierarchy. Both a consequence and a cause, ecotourism has transformed the island's social structure and demography. The theory and methods applied in this case study of interdisciplinary research in the field of human ecosystems are also presented.

  15. From structure of the complex to understanding of the biology

    Energy Technology Data Exchange (ETDEWEB)

    Rossmann, Michael G., E-mail: mr@purdue.edu [Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054 (United States); Arisaka, Fumio [Graduate School and School of Bioscience and Biotechnology, Tokyo Institute of Technology, 5249 Nagatsuta-cho, Yokohama 226-8501-B39 (Japan); Battisti, Anthony J.; Bowman, Valorie D.; Chipman, Paul R.; Fokine, Andrei; Hafenstein, Susan [Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054 (United States); Kanamaru, Shuji [Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054 (United States); Graduate School and School of Bioscience and Biotechnology, Tokyo Institute of Technology, 5249 Nagatsuta-cho, Yokohama 226-8501-B39 (Japan); Kostyuchenko, Victor A. [Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054 (United States); Mesyanzhinov, Vadim V.; Shneider, Mikhail M. [Laboratory of Molecular Bioengineering, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya Street, Moscow, 117997 (Russian Federation); Morais, Marc C.; Leiman, Petr G. [Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054 (United States); Palermo, Laura M.; Parrish, Colin R. [James A. Baker Institute, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (United States); Xiao, Chuan [Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054 (United States)

    2007-01-01

    The most extensive structural information on viruses relates to apparently icosahedral virions and is based on X-ray crystallography and on cryo-electron microscopy single-particle reconstructions. This paper concerns itself with the study of the macromolecular complexes that constitute viruses, using structural hybrid techniques. The most extensive structural information on viruses relates to apparently icosahedral virions and is based on X-ray crystallography and on cryo-electron microscopy (cryo-EM) single-particle reconstructions. Both techniques lean heavily on imposing icosahedral symmetry, thereby obscuring any deviation from the assumed symmetry. However, tailed bacteriophages have icosahedral or prolate icosahedral heads that have one obvious unique vertex where the genome can enter for DNA packaging and exit when infecting a host cell. The presence of the tail allows cryo-EM reconstructions in which the special vertex is used to orient the head in a unique manner. Some very large dsDNA icosahedral viruses also develop special vertices thought to be required for infecting host cells. Similarly, preliminary cryo-EM data for the small ssDNA canine parvovirus complexed with receptor suggests that these viruses, previously considered to be accurately icosahedral, might have some asymmetric properties that generate one preferred receptor-binding site on the viral surface. Comparisons are made between rhinoviruses that bind receptor molecules uniformly to all 60 equivalent binding sites, canine parvovirus, which appears to have a preferred receptor-binding site, and bacteriophage T4, which gains major biological advantages on account of its unique vertex and tail organelle.

  16. Understanding complex host-microbe interactions in Hydra

    Science.gov (United States)

    Bosch, Thomas C.G.

    2012-01-01

    Any multicellular organism may be considered a metaorganism or holobiont—comprised of the macroscopic host and synergistic interdependence with bacteria, archaea, fungi, viruses, and numerous other microbial and eukaryotic species including algal symbionts. Defining the individual microbe-host conversations in these consortia is a challenging but necessary step on the path to understanding the function of the associations as a whole. Dissecting the fundamental principles that underlie all host-microbe interactions requires simple animal models with only a few specific bacterial species. Here I present Hydra as such a model with one of the simplest epithelia in the animal kingdom, with the availability of a fully sequenced genome and numerous genomic tools, and with few associated bacterial species. PMID:22688725

  17. Plasma Metamaterials for Arbitrary Complex-Amplitude Wave Filters

    Science.gov (United States)

    2013-09-10

    ADDRESS(ES) Department of Electronic Science and Engineering,Kyoto University ,Kyoto-daigaku Katsura, ,Nishikyo-ku, Kyoto 615-8510, Japan ,NA,NA 8...Engineering, Kyoto University Mailing Address : Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto 615-8510, Japan Phone : +81-75-383-2289 Fax : +81...165003 (2005). 6 G. G. Borg , J. H. Harris, N. M. Martin, D. Thorncraft, R. Milliken, D. G. Miljak, B. Kwan, T. Ng, and J. Kircher, Phys. Plasmas 7

  18. Understanding Life : The Evolutionary Dynamics of Complexity and Semiosis

    Science.gov (United States)

    Loeckenhoff, Helmut K.

    2010-11-01

    Post-Renaissance sciences created different cultures. To establish an epistemological base, Physics were separated from the Mental domain. Consciousness was excluded from science. Life Sciences were left in between e.g. LaMettrie's `man—machine' (1748) and 'vitalism' [e.g. Bergson 4]. Causative thinking versus intuitive arguing limited strictly comprehensive concepts. First ethology established a potential shared base for science, proclaiming the `biology paradigm' in the middle of the 20th century. Initially procured by Cybernetics and Systems sciences, `constructivist' models prepared a new view on human perception and thus also of scientific `objectivity when introducing the `observer'. In sequel Computer sciences triggered the ICT revolution. In turn ICT helped to develop Chaos and Complexity sciences, Non-linear Mathematics and its spin-offs in the formal sciences [Spencer-Brown 49] as e.g. (proto-)logics. Models of life systems, as e.g. Anticipatory Systems, integrated epistemology with mathematics and Anticipatory Computing [Dubois 11, 12, 13, 14] connecting them with Semiotics. Seminal ideas laid in the turn of the 19th to the 20th century [J. v. Uexküll 53] detected the co-action and co-evolvement of environments and life systems. Bio-Semiotics ascribed purpose, intent and meaning as essential qualities of life. The concepts of Systems Biology and Qualitative Research enriched and develop also anthropologies and humanities. Brain research added models of (higher) consciousness. An avant-garde is contemplating a science including consciousness as one additional base. New insights from the extended qualitative approach led to re-conciliation of basic assumptions of scientific inquiry, creating the `epistemological turn'. Paradigmatically, resting on macro- micro- and recently on nano-biology, evolution biology sired fresh scripts of evolution [W. Wieser 60,61]. Its results tie to hypotheses describing the emergence of language, of the human mind and of

  19. Evaluating the Gifted Students' Understanding Related to Plasma State Using Plasma Experimental System and Two-Tier Diagnostic Test

    Science.gov (United States)

    Korkmaz, Saadet Deniz; Ayas, Bahadir; Aybek, Eren Can; Pat, Suat

    2018-01-01

    The purpose of this study was to investigate the effectiveness of the experimental system design related to plasma state on the gifted students' understanding on the subject of the plasma state. To test the research hypothesis, one group pretest-posttest research model was carried out with 18 eighth-grade (4 girls and 14 boys) gifted students in…

  20. Understanding the SOL flow in L-mode plasma on divertor tokamaks, and its influence on the plasma transport

    International Nuclear Information System (INIS)

    Asakura, Nobuyuki

    2007-01-01

    Significant progress has been made in understanding the driving mechanisms in SOL mass transport along the magnetic field lines (SOL flow). SOL flow measurements by Mach probes and impurity plume have been performed in L-mode plasma at various poloidal locations in divertor tokamaks. All results showed common SOL flow patterns: subsonic flow with parallel Mach number (M parallel ) of 0.2-1 was generated from the Low-Field-Side (LFS) SOL to the High-Field-Side (HFS) divertor for the ion ∇B drift towards the divertor. The SOL flow pattern was formed mainly by LFS-enhanced asymmetry in diffusion and by classical drifts. In addition, divertor detachment and/or intense puffing-and-pump enhanced the HFS SOL flow. Most codes have incorporated drift effects, and asymmetric diffusion was modelled to simulate the fast SOL flow. Influences of the fast SOL flow on the impurity flow in the SOL, shielding from core plasma, and deposition profile, were directly observed in experiments

  1. Measurements of student understanding on complex scientific reasoning problems

    Science.gov (United States)

    Izumi, Alisa Sau-Lin

    While there has been much discussion of cognitive processes underlying effective scientific teaching, less is known about the response nature of assessments targeting processes of scientific reasoning specific to biology content. This study used multiple-choice (m-c) and short-answer essay student responses to evaluate progress in high-order reasoning skills. In a pilot investigation of student responses on a non-content-based test of scientific thinking, it was found that some students showed a pre-post gain on the m-c test version while showing no gain on a short-answer essay version of the same questions. This result led to a subsequent research project focused on differences between alternate versions of tests of scientific reasoning. Using m-c and written responses from biology tests targeted toward the skills of (1) reasoning with a model and (2) designing controlled experiments, test score frequencies, factor analysis, and regression models were analyzed to explore test format differences. Understanding the format differences in tests is important for the development of practical ways to identify student gains in scientific reasoning. The overall results suggested test format differences. Factor analysis revealed three interpretable factors---m-c format, genetics content, and model-based reasoning. Frequency distributions on the m-c and open explanation portions of the hybrid items revealed that many students answered the m-c portion of an item correctly but gave inadequate explanations. In other instances students answered the m-c portion incorrectly yet demonstrated sufficient explanation or answered the m-c correctly and also provided poor explanations. When trying to fit test score predictors for non-associated student measures---VSAT, MSAT, high school grade point average, or final course grade---the test scores accounted for close to zero percent of the variance. Overall, these results point to the importance of using multiple methods of testing and of

  2. Entropy: A Unifying Path for Understanding Complexity in Natural, Artificial and Social Systems

    Science.gov (United States)

    2011-07-01

    us now address complex systems which include a substantial social component. We may start with economics and theory of finance. Given the long memory ...Entropy: A Unifying Path for Understanding Complexity in Natural, Artificial and Social Systems * Constantino Tsallis Centro Brasileiro de...Path for Understanding Complexity in Natural, Artificial and Social Systems 5a. CONTRACT NUMBER FA23861114006 5b. GRANT NUMBER 5c. PROGRAM ELEMENT

  3. Free Thermal Convection in Complex Plasma with Background-Gas Friction

    International Nuclear Information System (INIS)

    Ivlev, A. V.; Zhdanov, S. K.; Morfill, G. E.

    2007-01-01

    The onset of free thermal convection in complex fluids with background friction is theoretically investigated. It is shown that in the limit when friction prevails--opposite to the classic Rayleigh-Benard case--the onset is determined by a renormalized Rayleigh number and also depends on the Prandtl number. Such convection should be observable in experiments with complex plasmas

  4. Ideal gas behavior of a strongly-coupled complex (dusty) plasma

    OpenAIRE

    Oxtoby, Neil P.; Griffith, Elias J.; Durniak, Céline; Ralph, Jason F.; Samsonov, Dmitry

    2012-01-01

    In a laboratory, a two-dimensional complex (dusty) plasma consists of a low-density ionized gas containing a confined suspension of Yukawa-coupled plastic microspheres. For an initial crystal-like form, we report ideal gas behavior in this strongly coupled system during shock-wave experiments. This evidence supports the use of the ideal gas law as the equation of state for soft crystals such as those formed by dusty plasmas.

  5. Dust acoustic waves in complex plasmas at elevated pressure

    International Nuclear Information System (INIS)

    Filippov, A.V.; Starostin, A.N.; Tkachenko, I.M.; Fortov, V.E.

    2011-01-01

    The bi-Yukawa effective interaction potential with different screening constants is employed to calculate dust static correlation functions in the hyper-netted chain approximation and to generalize the theory of dust acoustic waves within the non-perturbative moment approach complemented by hydrodynamic considerations. For the bi-Yukawa interaction potential the sound speed becomes significantly wavenumber-dependent, an additional soft diffusion-like mode is predicted, and the static dielectric function is shown to take negative values. The results can be applied to non-equilibrium dusty plasmas at elevated pressure. -- Highlights: ► Bi-Yukawa interaction potential of dust particles with different screening lengths. ► Dust static correlation functions in the hyper-netted chain approximation. ► The moment and hydrodynamic approaches are in a good agreement at weak non-ideality. ► The dust acoustic wave phase and group velocities depend on the wavenumber. ► The moment approach hints the appearance of the diffusion-like soft mode.

  6. CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma

    DEFF Research Database (Denmark)

    Graversen, Jonas Heilskov; Madsen, Mette; Moestrup, Søren K

    2002-01-01

    CD163 is a highly expressed macrophage membrane protein belonging to the scavenger receptor cysteine rich (SRCR) domain family. The CD163 expression is induced by interleukin-6, interleukin-10 and glucocorticoids. Its function has remained unknown until recently when CD163 was identified...... as the endocytic receptor binding hemoglobin (Hb) in complex with the plasma protein haptoglobin (Hp). This specific receptor-ligand interaction leading to removal from plasma of the Hp-Hb complex-but not free Hp or Hb-now explains the depletion of circulating Hp in individuals with increased intravascular...... hemolysis. Besides having a detoxificating effect by removing Hb from plasma, the CD163-mediated endocytosis of the Hp-Hb complex may represent a major pathway for uptake of iron in the tissue macrophages. The novel functional linkage of CD163 and Hp, which both are induced during inflammation, also reveal...

  7. Advances in Understanding and Control of Plasma Rotation on DIII-D

    Science.gov (United States)

    Grierson, B. A.; Logan, N.; Haskey, S.; Ashourvan, A.; Ernst, D.; Chrystal, C.; Degrassie, J.; Boedo, J.; Tala, T.; Salmi, A.

    2017-10-01

    Momentum transport experiments on DIII-D have advanced our understanding of the origin of core and edge rotation by showing that (1) core rotation in low-torque electron-heated ITER-like plasmas displays hollowing driven by turbulence in the absence of MHD, (2) intrinsic rotation in torque-free electron-heated plasmas follows the favorable rho* and nu* scalings as previously found in intrinsic torque experiments using NBI, (3) the edge plasma rotation can be controlled through shaping of triangularity and X-point radius, and (4) rotation and density profiles have separate dependencies on the applied 3D field spectra. These advances inform strategies to avoid low torque disruptions by tailoring turbulent modes that minimize rotation hollowing, and provide confidence in dimensionless scaling of intrinsic torque and rotation to ITER. The triangularity and X-point position provide important new actuators on the rotation beyond neutral beam injection that are available for any diverted tokamak including ITER. The separate spectral dependencies of the momentum and density explain how quiescent braking as well as edge isolated ELM control are possible even in machines with limited toroidal harmonic EFC coils. Work supported by US DOE under DE-AC02-09CH11466,DE-FC02-04ER54698.

  8. New Developments In Particle Image Velocimetry (PIV) For The Study Of Complex Plasmas

    International Nuclear Information System (INIS)

    Thomas, Edward Jr.; Fisher, Ross; Shaw, Joseph; Jefferson, Robert; Cianciosa, Mark; Williams, Jeremiah

    2011-01-01

    Particle Image Velocimetry (PIV) is a fluid measurement technique in which the average displacement of small groups of particles is made by comparing a pair of images that are separated in time by an interval Δt. For over a decade, a several variations of the PIV technique, e.g., two-dimensional, stereoscopic, and tomographic PIV, have been used to characterize particle transport, instabilities, and the thermal properties of complex plasmas. This paper describes the basic principles involved in the PIV analysis technique and discusses potential future applications of PIV to the study of complex plasmas.

  9. Complexity methods applied to turbulence in plasma astrophysics

    Science.gov (United States)

    Vlahos, L.; Isliker, H.

    2016-09-01

    In this review many of the well known tools for the analysis of Complex systems are used in order to study the global coupling of the turbulent convection zone with the solar atmosphere where the magnetic energy is dissipated explosively. Several well documented observations are not easy to interpret with the use of Magnetohydrodynamic (MHD) and/or Kinetic numerical codes. Such observations are: (1) The size distribution of the Active Regions (AR) on the solar surface, (2) The fractal and multi fractal characteristics of the observed magnetograms, (3) The Self-Organised characteristics of the explosive magnetic energy release and (4) the very efficient acceleration of particles during the flaring periods in the solar corona. We review briefly the work published the last twenty five years on the above issues and propose solutions by using methods borrowed from the analysis of complex systems. The scenario which emerged is as follows: (a) The fully developed turbulence in the convection zone generates and transports magnetic flux tubes to the solar surface. Using probabilistic percolation models we were able to reproduce the size distribution and the fractal properties of the emerged and randomly moving magnetic flux tubes. (b) Using a Non Linear Force Free (NLFF) magnetic extrapolation numerical code we can explore how the emerged magnetic flux tubes interact nonlinearly and form thin and Unstable Current Sheets (UCS) inside the coronal part of the AR. (c) The fragmentation of the UCS and the redistribution of the magnetic field locally, when the local current exceeds a Critical threshold, is a key process which drives avalanches and forms coherent structures. This local reorganization of the magnetic field enhances the energy dissipation and influences the global evolution of the complex magnetic topology. Using a Cellular Automaton and following the simple rules of Self Organized Criticality (SOC), we were able to reproduce the statistical characteristics of the

  10. Using Simulations in Linked Courses to Foster Student Understanding of Complex Political Institutions

    Science.gov (United States)

    Williams, Michelle Hale

    2015-01-01

    Political institutions provide basic building blocks for understanding and comparing political systems. Yet, students often struggle to understand the implications of institutional choice, such as electoral system rules, especially when the formulas and calculations used to determine seat allocation can be multilevel and complex. This study brings…

  11. What Influences Children's and Adolescents' Understanding of the Complexity of the Internet?

    Science.gov (United States)

    Yan, Zheng

    2006-01-01

    This study aimed at analyzing complex relationships among Internet use, Internet users, and conceptual understanding of the Internet. It used path models to examine factors related to Internet use (duration of Internet use, frequency of Internet use, and informal Internet classes) and Internet users (age and gender) in affecting understanding of…

  12. Complex Plasmas under free fall conditions aboard the International Space Station

    Science.gov (United States)

    Konopka, Uwe; Thomas, Edward, Jr.; Funk, Dylan; Doyle, Brandon; Williams, Jeremiah; Knapek, Christina; Thomas, Hubertus

    2017-10-01

    Complex Plasmas are dynamically dominated by massive, highly negatively charged, micron-sized particles. They are usually strongly coupled and as a result can show fluid-like behavior or undergo phase transitions to form crystalline structures. The dynamical time scale of these systems is easily accessible in experiments because of the relatively high mass/inertia of the particles. However, the high mass also leads to sedimentation effects and as a result prevents the conduction of large scale, fully three dimensional experiments that are necessary to utilize complex plasmas as model systems in the transition to continuous media. To reduce sedimentation influences it becomes necessary to perform experiments in a free-fall (``microgravity'') environment, such as the ISS based experiment facility ``Plasma-Kristall-4'' (``PK-4''). In our paper we will present our recently started research activities to investigate the basic properties of complex plasmas by utilizing the PK-4 experiment facility aboard the ISS. We further give an overview of developments towards the next generation experiment facility ``Ekoplasma'' (formerly named ``PlasmaLab'') and discuss potential additional small-scale space-based experiment scenarios. This work was supported by the JPL/NASA (JPL-RSA 1571699), the US Dept. of Energy (DE-SC0016330) and the NSF (PHY-1613087).

  13. Superdiffusion and viscoelastic vortex flows in a two-dimensional complex plasma

    DEFF Research Database (Denmark)

    Ratynskaia, S.; Rypdal, K.; Knapek, C.

    2006-01-01

    Viscoelastic vortical fluid motion in a strongly coupled particle system has been observed experimentally. Optical tracking of particle motion in a complex plasma monolayer reveals high grain mobility and large scale vortex flows coexistent with partial preservation of the global hexagonal lattice...

  14. Comparison of MHD simulation codes for understanding nonlinear ELMs dynamics in KSTAR H-mode plasma

    Science.gov (United States)

    Kim, M.; Lee, J.; Park, H. K.; Yun, G. S.; Xu, X.; Jardin, S. C.; Becoulet, M.

    2017-10-01

    KSTAR electron cyclotron emission imaging (ECEI) systems have contributed to understanding the fundamental physics of ELMs by high-quality 2D and quasi-3D images of ELMs. However, in the highly nonlinear phase of ELM dynamics, the interpretation of ECE signals becomes complicated intrinsically. Theoretical and numerical approaches are necessary to enhance the understanding of ELM physics. Well-established MHD codes (BOUT + + , JOREK, and M3D-C1) are introduced for comparative study with the observations. The nonlinear solutions are obtained using the same equilibrium of the KSTAR H-mode plasma. Each code shows the partial difference in mode evolution, probably, due to the difference in optimized operation window of initial conditions. The nonlinear simulation results show that low- n (n qualitatively matches with the recent ECEI observation just before ELM-crash, or excitation of non-modal solitary perturbation (typically, n = 1) which is highly localized in poloidal and toroidal. Regardless of differences in details, qualitative similarity can provide inspiration to understand the triggering of ELM-crash. This work is supported by NRF of Korea under Contract No. NRF-2014M1A7A1A03029865.

  15. A primer on complex systems with applications to astrophysical and laboratory plasmas

    CERN Document Server

    Sánchez, Raúl

    2018-01-01

    The purpose of this book is to illustrate the fundamental concepts of complexity and complex behavior and the best methods to characterize this behavior by means of their applications to some current research topics from within the fields of fusion, earth and solar plasmas. In this sense, it is a departure from the many books already available that discuss general features of complexity. The book is divided in two parts. In the first part the most important properties and features of complex systems are introduced, discussed and illustrated. The second part discusses several instances of possible complex phenomena in magnetized plasmas and some of the analysis tools that were introduced in the first part are used to characterize the dynamics in these systems. A list of problems is proposed at the end of each chapter. This book is intended for graduate and post-graduate students with a solid college background in mathematics and classical physics, who intend to work in the field of plasma physics and, in parti...

  16. Understanding a Complex World: Why an Emphasis on Empathy Could Better Enable Army Leaders to Win

    Science.gov (United States)

    2016-06-10

    the problem of how to win in a complex world. 1 Brig. Gen. Oscar W. Koch and Robert G. Hayes, G-2: Intelligence for Patton (Atglen, PA: Schiffer...UNDERSTANDING A COMPLEX WORLD: WHY AN EMPHASIS ON EMPATHY COULD BETTER ENABLE ARMY LEADERS TO WIN A thesis presented to the...Leaders to Win 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Matthew J. Fontaine, MAJ 5d. PROJECT NUMBER

  17. Binding of canonical Wnt ligands to their receptor complexes occurs in ordered plasma membrane environments.

    Science.gov (United States)

    Sezgin, Erdinc; Azbazdar, Yagmur; Ng, Xue W; Teh, Cathleen; Simons, Kai; Weidinger, Gilbert; Wohland, Thorsten; Eggeling, Christian; Ozhan, Gunes

    2017-08-01

    While the cytosolic events of Wnt/β-catenin signaling (canonical Wnt signaling) pathway have been widely studied, only little is known about the molecular mechanisms involved in Wnt binding to its receptors at the plasma membrane. Here, we reveal the influence of the immediate plasma membrane environment on the canonical Wnt-receptor interaction. While the receptors are distributed both in ordered and disordered environments, Wnt binding to its receptors selectively occurs in more ordered membrane environments which appear to cointernalize with the Wnt-receptor complex. Moreover, Wnt/β-catenin signaling is significantly reduced when the membrane order is disturbed by specific inhibitors of certain lipids that prefer to localize at the ordered environments. Similarly, a reduction in Wnt signaling activity is observed in Niemann-Pick Type C disease cells where trafficking of ordered membrane lipid components to the plasma membrane is genetically impaired. We thus conclude that ordered plasma membrane environments are essential for binding of canonical Wnts to their receptor complexes and downstream signaling activity. © 2017 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

  18. Complex plasmas and colloidal dispersions particle-resolved studies of classical liquids and solids

    CERN Document Server

    Ivlev, Alexei; Morfill, Gregor; Royall, C. Patrick

    2012-01-01

    Complex plasmas and colloidal dispersions represent different states of soft matter. They are complementary in many ways, with the most important being that complex plasmas are virtually undamped at the particle timescales, whereas colloidal dispersions are overdamped and therefore can be brought into equilibrium in a very controlled manner. Otherwise, both fields have similar advantages: fully resolved 3D particle trajectories can easily be visualized, the pair interactions are tunable, and particles can be manipulated individually or collectively. These unique properties allow us to investigate generic processes occurring in liquids or solids at the most fundamental individual particle level. The principal research topics to be addressed in the book include: particle dynamics in liquids, with the emphasis on mesoscopic processes in the supercooled (glassy) state, e.g. dynamical heterogeneity, phase transitions in solids, with particular attention to the evolutionary paths of crystal structure development an...

  19. Speech Understanding in Complex Listening Environments by Listeners Fit with Cochlear Implants

    Science.gov (United States)

    Dorman, Michael F.; Gifford, Rene H.

    2017-01-01

    Purpose: The aim of this article is to summarize recent published and unpublished research from our 2 laboratories on improving speech understanding in complex listening environments by listeners fit with cochlear implants (CIs). Method: CI listeners were tested in 2 listening environments. One was a simulation of a restaurant with multiple,…

  20. Supersonic particle in a low damped complex plasma under microgravity conditions

    Science.gov (United States)

    Zaehringer, E.; Zhdanov, S.; Schwabe, M.; Mohr, D. P.; Knapek, C. A.; Huber, P.; Semenov, I.; Thomas, H. M.

    2018-01-01

    We discuss the diagnostics of a complex plasma cloud recorded in experiments performed in the framework of the Ekoplasma project. A supersonic extra particle is used as a probe of the cloud dynamics. A fine-structured Mach cone behind the supersonic particle is observed. We investigate the spatial and temporal development of the Mach cone with a computer based measurement to determine the speed of sound of the particle cloud. Also time and position dependent characteristics of the velocity field are recorded.

  1. Spectral Approach to Anderson Localization in a Disordered 2D Complex Plasma Crystal

    Science.gov (United States)

    Kostadinova, Eva; Liaw, Constanze; Matthews, Lorin; Busse, Kyle; Hyde, Truell

    2016-10-01

    In condensed matter, a crystal without impurities acts like a perfect conductor for a travelling wave-particle. As the level of impurities reaches a critical value, the resistance in the crystal increases and the travelling wave-particle experiences a transition from an extended to a localized state, which is called Anderson localization. Due to its wide applicability, the subject of Anderson localization has grown into a rich field in both physics and mathematics. Here, we introduce the mathematics behind the spectral approach to localization in infinite disordered systems and provide physical interpretation in context of both quantum mechanics and classical physics. We argue that the spectral analysis is an important contribution to localization theory since it avoids issues related to the use of boundary conditions, scaling, and perturbation. To test accuracy and applicability we apply the spectral approach to the case of a 2D hexagonal complex plasma crystal used as a macroscopic analog for a graphene-like medium. Complex plasma crystals exhibit characteristic distance and time scales, which are easily observable by video microscopy. As such, these strongly coupled many-particle systems are ideal for the study of localization phenomena. The goal of this research is to both expand the spectral method into the classical regime and show the potential of complex plasma as a macroscopic tool for localization experiments. NSF / DOE funding is gratefully acknowledged - PHY1414523 & PHY1262031.

  2. Circulating growth hormone (GH)-binding protein complex: a major constituent of plasma GH in man

    International Nuclear Information System (INIS)

    Baumann, G.; Amburn, K.; Shaw, M.A.

    1988-01-01

    The recent discovery of a specific binding protein for human GH (hGH) in human plasma suggests that hGH circulates in part as a complex in association with the binding protein(s). However, the magnitude of the complexed fraction prevailing under physiological conditions is unknown because of 1) dissociation of the complex during analysis and 2) potential differences in the binding characteristics of radiolabeled and native hGH. We conducted experiments designed to minimize dissociation during analysis (gel filtration in prelabeled columns, frontal analysis, and batch molecular sieving) with both native and radioiodinated hGH. All three methods yielded similar estimates for the complexed fraction. In normal plasma the bound fraction for 22 K hGH averaged 50.1% (range, 39-59%), that for 20 K hGH averaged 28.5% (range, 26-31%). Above a hGH level of about 20 ng/ml the bound fraction declines in concentration-dependent manner due to saturation of the binding protein. We conclude that a substantial part of circulating hGH is complexed with carrier proteins. This concept has important implications for the metabolism, distribution, and biological activity of hGH

  3. Understanding the implementation of complex interventions in health care: the normalization process model

    Directory of Open Access Journals (Sweden)

    Rogers Anne

    2007-09-01

    Full Text Available Abstract Background The Normalization Process Model is a theoretical model that assists in explaining the processes by which complex interventions become routinely embedded in health care practice. It offers a framework for process evaluation and also for comparative studies of complex interventions. It focuses on the factors that promote or inhibit the routine embedding of complex interventions in health care practice. Methods A formal theory structure is used to define the model, and its internal causal relations and mechanisms. The model is broken down to show that it is consistent and adequate in generating accurate description, systematic explanation, and the production of rational knowledge claims about the workability and integration of complex interventions. Results The model explains the normalization of complex interventions by reference to four factors demonstrated to promote or inhibit the operationalization and embedding of complex interventions (interactional workability, relational integration, skill-set workability, and contextual integration. Conclusion The model is consistent and adequate. Repeated calls for theoretically sound process evaluations in randomized controlled trials of complex interventions, and policy-makers who call for a proper understanding of implementation processes, emphasize the value of conceptual tools like the Normalization Process Model.

  4. Biologically Complex Planar Cell Plasma Membranes Supported on Polyelectrolyte Cushions Enhance Transmembrane Protein Mobility and Retain Native Orientation.

    Science.gov (United States)

    Liu, Han-Yuan; Chen, Wei-Liang; Ober, Christopher K; Daniel, Susan

    2018-01-23

    Reconstituted supported lipid bilayers (SLB) are widely used as in vitro cell-surface models because they are compatible with a variety of surface-based analytical techniques. However, one of the challenges of using SLBs as a model of the cell surface is the limited complexity in membrane composition, including the incorporation of transmembrane proteins and lipid diversity that may impact the activity of those proteins. Additionally, it is challenging to preserve the transmembrane protein native orientation, function, and mobility in SLBs. Here, we leverage the interaction between cell plasma membrane vesicles and polyelectrolyte brushes to create planar bilayers from cell plasma membrane vesicles that have budded from the cell surface. This approach promotes the direct incorporation of membrane proteins and other species into the planar bilayer without using detergent or reconstitution and preserves membrane constituents. Furthermore, the structure of the polyelectrolyte brush serves as a cushion between the planar bilayer and rigid supporting surface, limiting the interaction of the cytosolic domains of membrane proteins with this surface. Single particle tracking was used to analyze the motion of GPI-linked yellow fluorescent proteins (GPI-YFP) and neon-green fused transmembrane P2X2 receptors (P2X2-neon) and shows that this platform retains over 75% mobility of multipass transmembrane proteins in its native membrane environment. An enzyme accessibility assay confirmed that the protein orientation is preserved and results in the extracellular domain facing toward the bulk phase and the cytosolic side facing the support. Because the platform presented here retains the complexity of the cell plasma membrane and preserves protein orientation and mobility, it is a better representative mimic of native cell surfaces, which may find many applications in biological assays aimed at understanding cell membrane phenomena.

  5. Biomechanism of chlorogenic acid complex mediated plasma free fatty acid metabolism in rat liver.

    Science.gov (United States)

    H V, Sudeep; K, Venkatakrishna; Patel, Dipak; K, Shyamprasad

    2016-08-05

    Plasma free fatty acids (FFA) are involved in blood lipid metabolism as well as many health complications. The present study was conducted to evaluate the potential role of chlorogenic acid complex from green coffee bean (CGA7) on FFA metabolism in high fat diet fed rats. Hyperlipidemia was induced in Wistar rats using high-fat diet. The animals were given CGA7/orlistat concurrently for 42 days. The parameters analysed during the study include plasma and liver total cholesterol (TC), Triglycerides (TG) and FFA. AMPK activation in the liver was analysed through ELISA. The multiple factors involved in AMPK mediated FFA metabolism were analysed using western blotting. CGA7 (50, 100, 150 mg/kg BW) decreased triglycerides (TG) and FFA levels in plasma and liver. CGA7 administration led to the activation of AMP-activated protein kinase (AMPK) and a subsequent increase in the levels of carnitine palmitoyltransferase 1 (CPT-1). There was a decrease in acetyl-CoA carboxylase (ACC) activity as evident by the increase in its phosphorylation level. Chlorogenic acids improved the blood lipid metabolism in rats by alleviating the levels of FFA and TG, modulating the multiple factors in liver through AMPK pathway. The study concludes that CGA7 complex can be promoted as an active ingredient in nutrition for obesity management.

  6. Understanding the dimensions of intensive care: transpersonal caring and complexity theories.

    Science.gov (United States)

    do Nascimento, Keyla Cristiane; Erdmann, Alacoque Lorenzini

    2009-01-01

    This is a descriptive, interpretive and qualitative study carried out at the ICU of a Brazilian teaching hospital. It aimed to understand the dimensions of human caring experienced by health care professionals, clients and their family members at an ICU, based on human caring complexity. The Transpersonal Caring and Complexity theories support theory and data analysis. The following dimensions of care emerged from the themes analyzed according to Ricoeur: self-care, care as an individual value, professional vs. informal care, care as supportive relationship, affective care, humanized care, care as act/attitude, care practice; educative care, dialogical relationship, care coupled to technology, loving care, interactive care, non-care, care ambience, the essence of life and profession, and meaning/purpose of care. We believe in care that encompasses several dimensions presented here, based on the relationship with the other, on the empathetic, sensitive, affectionate, creative, dynamic and understanding being in the totality of the human being.

  7. Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer

    DEFF Research Database (Denmark)

    Thorsen, Stine Buch; Christensen, Sarah Louise T; Würtz, Sidse Ørnbjerg

    2013-01-01

    Worldwide more than one million women are annually diagnosed with breast cancer. A considerable fraction of these women receive systemic adjuvant therapy; however, some are cured by primary surgery and radiotherapy alone. Prognostic biomarkers guide stratification of patients into different risk...... groups and hence improve management of breast cancer patients. Plasma levels of Matrix Metalloproteinase-9 (MMP-9) and its natural inhibitor Tissue inhibitor of metalloproteinase-1 (TIMP-1) have previously been associated with poor patient outcome and resistance to certain forms of chemotherapy....... To pursue additional prognostic information from MMP-9 and TIMP-1, the level of the MMP-9 and TIMP-1 complex (MMP-9:TIMP-1) was investigated in plasma from breast cancer patients....

  8. Toward understanding the thermodynamics of TALSPEAK process. Medium effects on actinide complexation

    Energy Technology Data Exchange (ETDEWEB)

    Peter R Zalupski; Leigh R Martin; Ken Nash; Yoshinobu Nakamura; Masahiko Yamamoto

    2009-07-01

    The ingenious combination of lactate and diethylenetriamine-N,N,N’,N”,N”-pentaacetic acid (DTPA) as an aqueous actinide-complexing medium forms the basis of the successful separation of americium and curium from lanthanides known as the TALSPEAK process. While numerous reports in the prior literature have focused on the optimization of this solvent extraction system, considerably less attention has been devoted to the understanding of the basic thermodynamic features of the complex fluids responsible for the separation. The available thermochemical information of both lactate and DTPA protonation and metal complexation reactions are representative of the behavior of these ions under idealized conditions. Our previous studies of medium effects on lactate protonation suggest that significant departures from the speciation predicted based on reported thermodynamic values should be expected in the TALSPEAK aqueous environment. Thermodynamic parameters describing the separation chemistry of this process thus require further examination at conditions significantly removed from conventional ideal systems commonly employed in fundamental solution chemistry. Such thermodynamic characterization is the key to predictive modelling of TALSPEAK. Improved understanding will, in principle, allow process technologists to more efficiently respond to off-normal conditions during large scale process operation. In this report, the results of calorimetric and potentiometric investigations of the effects of aqueous electrolytes on the thermodynamic parameters for lactate protonation and lactate complexation of americium and neodymium will be presented. Studies on the lactate protonation equilibrium will clearly illustrate distinct thermodynamic variations between strong electrolyte aqueous systems and buffered lactate environment.

  9. Progress in Understanding Error-field Physics in NSTX Spherical Torus Plasmas

    Energy Technology Data Exchange (ETDEWEB)

    E. Menard, R.E. Bell, D.A. Gates, S.P. Gerhardt, J.-K. Park, S.A. Sabbagh, J.W. Berkery, A. Egan, J. Kallman, S.M. Kaye, B. LeBlanc, Y.Q. Liu, A. Sontag, D. Swanson, H. Yuh, W. Zhu and the NSTX Research Team

    2010-05-19

    The low aspect ratio, low magnetic field, and wide range of plasma beta of NSTX plasmas provide new insight into the origins and effects of magnetic field errors. An extensive array of magnetic sensors has been used to analyze error fields, to measure error field amplification, and to detect resistive wall modes in real time. The measured normalized error-field threshold for the onset of locked modes shows a linear scaling with plasma density, a weak to inverse dependence on toroidal field, and a positive scaling with magnetic shear. These results extrapolate to a favorable error field threshold for ITER. For these low-beta locked-mode plasmas, perturbed equilibrium calculations find that the plasma response must be included to explain the empirically determined optimal correction of NSTX error fields. In high-beta NSTX plasmas exceeding the n=1 no-wall stability limit where the RWM is stabilized by plasma rotation, active suppression of n=1 amplified error fields and the correction of recently discovered intrinsic n=3 error fields have led to sustained high rotation and record durations free of low-frequency core MHD activity. For sustained rotational stabilization of the n=1 RWM, both the rotation threshold and magnitude of the amplification are important. At fixed normalized dissipation, kinetic damping models predict rotation thresholds for RWM stabilization to scale nearly linearly with particle orbit frequency. Studies for NSTX find that orbit frequencies computed in general geometry can deviate significantly from those computed in the high aspect ratio and circular plasma cross-section limit, and these differences can strongly influence the predicted RWM stability. The measured and predicted RWM stability is found to be very sensitive to the E × B rotation profile near the plasma edge, and the measured critical rotation for the RWM is approximately a factor of two higher than predicted by the MARS-F code using the semi-kinetic damping model.

  10. Collaborative Research: Understanding Ion Losses to Plasma Boundaries Sheaths and Presheaths

    Energy Technology Data Exchange (ETDEWEB)

    Hershkowitz, Noah [Univ. of Wisconsin, Madison, WI (United States)

    2015-10-01

    Sheaths are common to all bounded steady-state plasmas. This includes laboratory, industrial, fusion, and in some cases even space plasmas. They form in general to balance particle loss and maintain quasi-neutrality in plasmas. Electrons are lighter than the ions by 2000 times or more (depending on the gas), and in most plasmas ion temperatures are rarely higher than the electron temperature and generally much lower. Thus in most cases, negative potential sheaths occur to confine electrons and allow ions to be freely lost. We have investigated how a plasma locally response to a positive bias on a small electrode, and have established area criteria which plasma reacts differently to the positive bias – first a pure electron sheath, and a global non-ambipolar regime where all electrons are lost to the electrode, and a double layer structure identified as a virtual cathode forms to limiting electron loss and maintain quasi-neutrality, and finally a anode spot regime where a secondary discharge occurs in front of the electrode, turning it into the major loss area of the entire plasma. Electrode area and plasma parameters criteria for these regimes were established, and the effect of the virtual cathode on the electrode’s I-V characteristics was investigated. We have also developed a global non-ambipolar electron source to replace hollow cathodes in a number of plasma applications. This eliminates the lifetime limitation and maintenance cost of hollow cathodes as they easily wear out easily and cannot be replaced in space applications.

  11. Understanding the GPCR biased signaling through G protein and arrestin complex structures.

    Science.gov (United States)

    Zhou, X Edward; Melcher, Karsten; Xu, H Eric

    2017-08-01

    G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors and are important drug targets for many human diseases. The determination of the 3-D structure of GPCRs and their signaling complexes has promoted our understanding of GPCR biology and provided templates for structure-based drug discovery. In this review, we focus on the recent structure work on GPCR signaling complexes, the β2-adrenoreceptor-Gs and the rhodopsin-arrestin complexes in particular, and highlight the structural features of GPCR complexes involved in G protein- and arrestin-mediated signal transduction. The crystal structures reveal distinct structural mechanisms by which GPCRs recruit a G protein and an arrestin. A comparison of the two complex structures provides insight into the molecular mechanism of functionally selective GPCR signaling, and a structural basis for the discovery of G protein- and arrestin-biased treatments of human diseases related to GPCR signal transduction. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Proteomic screen for multiprotein complexes in synaptic plasma membrane from rat hippocampus by blue native gel electrophoresis and tandem mass spectrometry.

    Science.gov (United States)

    Li, Xuanwen; Xie, Chunliang; Jin, Qihui; Liu, Mingjun; He, Quanyuan; Cao, Rui; Lin, Yong; Li, Jianglin; Li, Yan; Chen, Ping; Liang, Songping

    2009-07-01

    Neuronal synapses are specialized sites for information exchange between neurons. Many diseases, such as addiction and mood disorders, likely result from altered expression of synaptic proteins, or altered formation of synaptic complexes involved in neurotransmission or neuroplasticity. A detailed description of native multiprotein complexes in synaptic plasma membranes (PM) is therefore essential for understanding biological mechanisms and disease processes. For the first time in this study, two-dimensional Blue Native/SDS-PAGE electrophoresis, combined with tandem mass spectrometry, was used to screen multiprotein complexes in synaptic plasma membranes from rat hippocampus. As a result, 514 unique proteins were identified, of which 36% were integral membrane proteins. In addition, 19 potentially novel and known heterooligomeric multiprotein complexes were found, such as the SNARE and ATPase complexes. A potentially novel protein complex, involving syntaxin, synapsin I and Na+/K+ ATPase alpha-1, was further confirmed by co-immunoprecipitation and immunofluorescence staining. As demonstrated here, Blue Native-PAGE is a powerful tool for the separation of hydrophobic membrane proteins. The combination of Blue Native-PAGE and mass spectrometry could systematically identify multiprotein complexes.

  13. Latest Results on Complex Plasmas with the PK-3 Plus Laboratory on Board the International Space Station

    Science.gov (United States)

    Schwabe, M.; Du, C.-R.; Huber, P.; Lipaev, A. M.; Molotkov, V. I.; Naumkin, V. N.; Zhdanov, S. K.; Zhukhovitskii, D. I.; Fortov, V. E.; Thomas, H. M.

    2018-03-01

    Complex plasmas are low temperature plasmas that contain microparticles in addition to ions, electrons, and neutral particles. The microparticles acquire high charges, interact with each other and can be considered as model particles for effects in classical condensed matter systems, such as crystallization and fluid dynamics. In contrast to atoms in ordinary systems, their movement can be traced on the most basic level, that of individual particles. In order to avoid disturbances caused by gravity, experiments on complex plasmas are often performed under microgravity conditions. The PK-3 Plus Laboratory was operated on board the International Space Station from 2006 - 2013. Its heart consisted of a capacitively coupled radio-frequency plasma chamber. Microparticles were inserted into the low-temperature plasma, forming large, homogeneous complex plasma clouds. Here, we review the results obtained with recent analyzes of PK-3 Plus data: We study the formation of crystallization fronts, as well as the microparticle motion in, and structure of crystalline complex plasmas. We investigate fluid effects such as wave transmission across an interface, and the development of the energy spectra during the onset of turbulent microparticle movement. We explore how abnormal particles move through, and how macroscopic spheres interact with the microparticle cloud. These examples demonstrate the versatility of the PK-3 Plus Laboratory.

  14. Collaborative Research: Atmospheric Pressure Plasma-Biomaterial Surface Interactions - Bridging Understanding of APP Sources to Rational Modification of Biomolecules

    Energy Technology Data Exchange (ETDEWEB)

    Graves, David Barry [Univ. of California, Berkeley, CA (United States)

    2017-11-24

    The overriding objective of this work is to bridge the gap between understanding of atmospheric pressure plasma (APP) sources and predictive chemical modifications of biomolecules. A key aspect of this problem is to understand what oxidizing species are created in water adjacent to APP jets that would ultimately affect aqueous biomolecules. We report the production of highly oxidative species in solutions exposed to a self-pulsed corona discharge in air. We examine how the properties of the target solution (pH, conductivity) and the discharge power affect the discharge stability and the production of H2O2. Indigo carmine, a common organic dye, is used as an indicator of oxidative strength and in particular, hydroxyl radical (OH•) production. The observed rate of indigo oxidation in contact with the discharge far exceeds that predicted from reactions based on concentrations of species measured in the bulk solution. The generation of H2O2 and the oxidation of indigo carmine indicate a high concentration of highly oxidizing species such as OH• at the plasma-liquid interface. These results indicate that reactions at the air plasma-liquid interface play a dominant role in species oxidation during direct non-equilibrium atmospheric pressure plasma (NE-APP) treatment.

  15. On the origin of dust vortices in complex plasmas under microgravity conditions

    Energy Technology Data Exchange (ETDEWEB)

    Bockwoldt, Tim, E-mail: bockwoldt@physik.uni-kiel.de; Arp, Oliver; Piel, Alexander [IEAP, Christian-Albrechts-Universität zu Kiel, D–24098 Kiel (Germany); Menzel, Kristoffer Ole [ABB Switzerland Ltd., Corporate Research Center, 5405 Dättwil (Switzerland)

    2014-10-15

    Under microgravity conditions, microparticles in a radio-frequency plasma form an extended dust cloud. In such clouds, self-excited large-scale vortices are observed. New experimental observations are reported, which exhibit a simple double vortex structure or a more complex quadrupole-like topology. Modeling the fields of the main acting forces, namely, the electric field force and the ion drag force, and calculating the curl of these forces reveal their non-conservative character and the possible driving mechanism of the vortices. It is shown that the curl of the ion drag force and of the electric field force has opposite sign and the combination could thus lead to the complex structures, also found in the observations.

  16. Perspectives of experimental and theoretical studies of self-organized dust structures in complex plasmas under microgravity conditions

    International Nuclear Information System (INIS)

    Tsytovich, V N

    2015-01-01

    We review research aimed at understanding the phenomena occurring in a complex plasma under microgravity conditions. Some aspects of the work already performed are considered that have not previously been given sufficient attention but which are potentially crucial for future work. These aspects, in particular, include the observation of compact dust structures that are estimated to be capable of confining all components of a dust plasma in a bounded spatial volume; experimental evidence of the nonlinear screening of dust particles; and experimental evidence of the excitation of collective electric fields. In theoretical terms, novel collective attraction processes between likely charged dust particles are discussed and all schemes of the shadowy attraction between dust particles used earlier, including in attempts to interpret observations, are reviewed and evaluated. Dust structures are considered from the standpoint of the current self-organization theory. It is emphasized that phase transitions between states of self-organized systems differ significantly from those in homogeneous states and that the phase diagrams should be constructed in terms of the parameters of a self-organized structure and cannot be constructed in terms of the temperature and density or similar parameters of homogeneous structures. Using the existing theoretical approaches to modeling self-organized structures in dust plasmas, the parameter distribution of a structure is recalculated for a simpler model that includes the quasineutrality condition and neglects diffusion. These calculations indicate that under microgravity conditions, any self-organized structure can contain a limited number of dust particles and is finite in size. The maximum possible number of particles in a structure determines the characteristic inter-grain distance in dust crystals that can be created under microgravity conditions. Crystallization criteria for the structures are examined and the quasispherical

  17. Mediation, moderation, and context: Understanding complex relations among cognition, affect, and health behaviour.

    Science.gov (United States)

    Kiviniemi, Marc T; Ellis, Erin M; Hall, Marissa G; Moss, Jennifer L; Lillie, Sarah E; Brewer, Noel T; Klein, William M P

    2018-01-01

    Researchers have historically treated cognition and affect as separate constructs in motivating health behaviour. We present a framework and empirical evidence for complex relations between cognition and affect in predicting health behaviour. Main Outcome, Design and Results: First, affect and cognition can mediate each other's relation to health behaviour. Second, affect and cognition can moderate the other's impact. Third, context can change the interplay of affect and cognition. Fourth, affect and cognition may be indelibly fused in some psychological constructs (e.g. worry, anticipated regret and reactance). These four propositions in our framework are not mutually exclusive. Examination of the types of complex relations described here can benefit theory development, empirical testing of theories and intervention design. Doing so will advance the understanding of mechanisms involved in regulation of health behaviours and the effectiveness of interventions to change health behaviours.

  18. Surface-wave sustained plasmas: Toward a better understanding of RF and microwave discharges

    Energy Technology Data Exchange (ETDEWEB)

    Moisan, M. [Groupe de physique des plasmas, Universite de Montreal, Montreal H3C 3J7, Quebec (Canada); Ferreira, C.M. [Centro de Electrodinamica da Universidade Tecnica de Lisboa, Instituto Superior Tecnico, Lisboa 1000 (Portugal); Hubert, J.; Margot, J. [Groupe de physique des plasmas, Universite de Montreal, Montreal H3C 3J7, Quebec (Canada); Zakrzewski, Z. [Polish Academy of Sciences, IMP-PAN, 80-952 Gdansk (Poland)

    1996-03-01

    An approach is presented that unifies the description of the various existing RF and microwave discharges. It is based on two essential facts: (i) it is not the spatial distribution of the high frequency (HF) electric field intensity but its spatial average that plays in the power transfer to the plasma; (ii) the power {theta} required to maintain an electron in the discharge is governed by charged particle losses, which are independent of the HF E-field. This enables one to model separately the maintenance processes of HF discharges and the electrodynamic properties of HF circuits sustaining the plasma, although the discharge and the HF field are actually coupled self-consistently. The influence of the field frequency on the properties of these plasmas is also summarized. {copyright} {ital 1996 American Institute of Physics.}

  19. Understanding valve program complexity in a refurbishment environment - learning from the past

    International Nuclear Information System (INIS)

    Roth, H.E.

    2012-01-01

    The complexity of Valve Program development, planning, execution and management in a refurbishment environment is an enormous undertaking requiring the proper coordination and integration of many moving parts. As such, lack of attention and understanding of this complexity has led to significant cost and schedule overruns in past refurbishment projects in the province. OPEX indicates the challenges in completing valve scope during refurbishments are related but not limited to; lack of detailed condition assessments, improper scope development, insignificant strategic approach to work task planning, scheduling and procurement, absence of contingency planning for common ‘as found’ conditions during execution, lack of proper training requirements, etc. In addition, past contracting strategies to employ numerous companies in collaboration to complete such a complex and specialized program, has resulted in further complications surrounding the management and integration of multiple quality programs and internal company processes. Finally, the aftermath of such fragmented projects results in an absolute closeout nightmare, often times taking years to locate, sift through and re-integrate pertinent information back into customer systems. Valve Program complexity cannot be understood by just anyone, only those that have lived through a refurbishment project and experienced the challenges mentioned above have the knowledge, skill, and ability to appreciate how to tactically apply past learning to realize future improvements. Furthermore, effective contractor-customer collaboration is crucial; true and in-depth knowledge and understanding of the customer quality programs, engineering and work management processes, configuration management requirements, and most importantly the imperative significance of nuclear safety, are all essential components to ensure overall alignment and program success. (author)

  20. Understanding, creating, and managing complex techno-socio-economic systems: Challenges and perspectives

    Science.gov (United States)

    Helbing, D.; Balietti, S.; Bishop, S.; Lukowicz, P.

    2011-05-01

    This contribution reflects on the comments of Peter Allen [1], Bikas K. Chakrabarti [2], Péter Érdi [3], Juval Portugali [4], Sorin Solomon [5], and Stefan Thurner [6] on three White Papers (WP) of the EU Support Action Visioneer (www.visioneer.ethz.ch). These White Papers are entitled "From Social Data Mining to Forecasting Socio-Economic Crises" (WP 1) [7], "From Social Simulation to Integrative System Design" (WP 2) [8], and "How to Create an Innovation Accelerator" (WP 3) [9]. In our reflections, the need and feasibility of a "Knowledge Accelerator" is further substantiated by fundamental considerations and recent events around the globe. newpara The Visioneer White Papers propose research to be carried out that will improve our understanding of complex techno-socio-economic systems and their interaction with the environment. Thereby, they aim to stimulate multi-disciplinary collaborations between ICT, the social sciences, and complexity science. Moreover, they suggest combining the potential of massive real-time data, theoretical models, large-scale computer simulations and participatory online platforms. By doing so, it would become possible to explore various futures and to expand the limits of human imagination when it comes to the assessment of the often counter-intuitive behavior of these complex techno-socio-economic-environmental systems. In this contribution, we also highlight the importance of a pluralistic modeling approach and, in particular, the need for a fruitful interaction between quantitative and qualitative research approaches. newpara In an appendix we briefly summarize the concept of the FuturICT flagship project, which will build on and go beyond the proposals made by the Visioneer White Papers. EU flagships are ambitious multi-disciplinary high-risk projects with a duration of at least 10 years amounting to an envisaged overall budget of 1 billion EUR [10]. The goal of the FuturICT flagship initiative is to understand and manage complex

  1. Toward understanding the thermodynamics of TALSPEAK process. Medium effects on actinide complexation

    International Nuclear Information System (INIS)

    Zalupski, Peter R.; Martin, Leigh R.; Nash, Ken; Nakamura, Yoshinobu; Yamamoto, Masahiko

    2009-01-01

    The ingenious combination of lactate and diethylenetriamine-N,N,N',N(double p rime),N(double p rime)-pentaacetic acid (DTPA) as an aqueous actinide-complexing medium forms the basis of the successful separation of americium and curium from lanthanides known as the TALSPEAK process. While numerous reports in the prior literature have focused on the optimization of this solvent extraction system, considerably less attention has been devoted to the understanding of the basic thermodynamic features of the complex fluids responsible for the separation. The available thermochemical information of both lactate and DTPA protonation and metal complexation reactions are representative of the behavior of these ions under idealized conditions. Our previous studies of medium effects on lactate protonation suggest that significant departures from the speciation predicted based on reported thermodynamic values should be expected in the TALSPEAK aqueous environment. Thermodynamic parameters describing the separation chemistry of this process thus require further examination at conditions significantly removed from conventional ideal systems commonly employed in fundamental solution chemistry. Such thermodynamic characterization is the key to predictive modelling of TALSPEAK. Improved understanding will, in principle, allow process technologists to more efficiently respond to off-normal conditions during large scale process operation. In this report, the results of calorimetric and potentiometric investigations of the effects of aqueous electrolytes on the thermodynamic parameters for lactate protonation and lactate complexation of americium and neodymium will be presented. Studies on the lactate protonation equilibrium will clearly illustrate distinct thermodynamic variations between strong electrolyte aqueous systems and buffered lactate environment.

  2. Plasma physics and fusion plasma electrodynamics

    CERN Document Server

    Bers, Abraham

    2016-01-01

    Plasma is a ubiquitous state of matter at high temperatures. The electrodynamics of plasmas encompasses a large number of applications, from understanding plasmas in space and the stars, to their use in processing semiconductors, and their role in controlled energy generation by nuclear fusion. This book covers collective and single particle dynamics of plasmas for fully ionized as well as partially ionized plasmas. Many aspects of plasma physics in current fusion energy generation research are addressed both in magnetic and inertial confinement plasmas. Linear and nonlinear dynamics in hydrodynamic and kinetic descriptions are offered, making both simple and complex aspects of the subject available in nearly every chapter. The approach of dividing the basic aspects of plasma physics as "linear, hydrodynamic descriptions" to be covered first because they are "easier", and postponing the "nonlinear and kinetic descriptions" for later because they are "difficult" is abandoned in this book. For teaching purpose...

  3. Understanding narrow SOL power flux component in COMPASS limiter plasmas by use of Langmuir probes

    Czech Academy of Sciences Publication Activity Database

    Dejarnac, Renaud; Stangeby, P.C.; Goldston, R.J.; Gauthier, E.; Horáček, Jan; Hron, Martin; Kocan, M.; Komm, Michael; Pánek, Radomír; Pitts, R.A.; Vondráček, Petr

    2015-01-01

    Roč. 463, August (2015), s. 381-384 ISSN 0022-3115. [PLASMA-SURFACE INTERACTIONS 21: International Conference on Plasma-Surface Interactions in Controlled Fusion Devices. Kanazawa, 26.05.2014-30.05.2014] R&D Projects: GA ČR GAP205/11/2341; GA ČR(CZ) GAP205/12/2327; GA MŠk(CZ) LM2011021 Institutional support: RVO:61389021 Keywords : COMPASS * tokamak * Heat loads * limiter * narrow channel * probes Subject RIV: JF - Nuclear Energetics OBOR OECD: Nuclear related engineering Impact factor: 2.199, year: 2015 http://www.sciencedirect.com/science/article/pii/S0022311514010538#

  4. Understanding and suppressing the near Scrape-Off Layer in inboard-limited plasmas in TCV.

    Czech Academy of Sciences Publication Activity Database

    Nespoli, F.; Labit, B.; Furno, I.; Horáček, Jan; Tsui, C.K.; Boedo, J. A.; Maurizio, R.; Reimerdes, H.; Theiler, C.; Ricci, P.; Halpern, F.D.; Sheikh, U.; Verhaegh, K.; Pitts, R.A.; Militello, F.

    2017-01-01

    Roč. 57, č. 12 (2017), č. článku 126029. ISSN 0029-5515 R&D Projects: GA ČR(CZ) GA15-10723S EU Projects: European Commission(XE) 633053 - EUROfusion Institutional support: RVO:61389021 Keywords : tokamak * TCV * scrape-off layer * heat flux * limiter * infrared thermography * Langmuir probes Subject RIV: BL - Plasma and Gas Discharge Physics OBOR OECD: Fluids and plasma physics (including surface physics) Impact factor: 3.307, year: 2016 http://iopscience.iop.org/article/10.1088/1741-4326/aa84e0

  5. Tech-X Corporation releases simulation code for solving complex problems in plasma physics : VORPAL code provides a robust environment for simulating plasma processes in high-energy physics, IC fabrications and material processing applications

    CERN Multimedia

    2005-01-01

    Tech-X Corporation releases simulation code for solving complex problems in plasma physics : VORPAL code provides a robust environment for simulating plasma processes in high-energy physics, IC fabrications and material processing applications

  6. The applications of Complexity Theory and Tsallis Non-extensive Statistics at Solar Plasma Dynamics

    Science.gov (United States)

    Pavlos, George

    2015-04-01

    As the solar plasma lives far from equilibrium it is an excellent laboratory for testing complexity theory and non-equilibrium statistical mechanics. In this study, we present the highlights of complexity theory and Tsallis non extensive statistical mechanics as concerns their applications at solar plasma dynamics, especially at sunspot, solar flare and solar wind phenomena. Generally, when a physical system is driven far from equilibrium states some novel characteristics can be observed related to the nonlinear character of dynamics. Generally, the nonlinearity in space plasma dynamics can generate intermittent turbulence with the typical characteristics of the anomalous diffusion process and strange topologies of stochastic space plasma fields (velocity and magnetic fields) caused by the strange dynamics and strange kinetics (Zaslavsky, 2002). In addition, according to Zelenyi and Milovanov (2004) the complex character of the space plasma system includes the existence of non-equilibrium (quasi)-stationary states (NESS) having the topology of a percolating fractal set. The stabilization of a system near the NESS is perceived as a transition into a turbulent state determined by self-organization processes. The long-range correlation effects manifest themselves as a strange non-Gaussian behavior of kinetic processes near the NESS plasma state. The complex character of space plasma can also be described by the non-extensive statistical thermodynamics pioneered by Tsallis, which offers a consistent and effective theoretical framework, based on a generalization of Boltzmann - Gibbs (BG) entropy, to describe far from equilibrium nonlinear complex dynamics (Tsallis, 2009). In a series of recent papers, the hypothesis of Tsallis non-extensive statistics in magnetosphere, sunspot dynamics, solar flares, solar wind and space plasma in general, was tested and verified (Karakatsanis et al., 2013; Pavlos et al., 2014; 2015). Our study includes the analysis of solar plasma time

  7. Clinical implications and biochemical understanding of high plasma vitamin B12 levels

    DEFF Research Database (Denmark)

    Arendt, Johan Frederik Håkonsen

    2016-01-01

    Måling af plasma cobalamin (Cbl, vitamin B12) anvendes i klinisk praksis til at diagnosticere eller udelukke Cbl-mangel. Denne mangeltilstand kan give blodmangel og symptomer fra mave- tarmkanalen og nervesystemet. Veganere, ældre og patienter med sygdomme eller tidligere operationer på mave...

  8. Understanding the topological characteristics and flow complexity of urban traffic congestion

    Science.gov (United States)

    Wen, Tzai-Hung; Chin, Wei-Chien-Benny; Lai, Pei-Chun

    2017-05-01

    For a growing number of developing cities, the capacities of streets cannot meet the rapidly growing demand of cars, causing traffic congestion. Understanding the spatial-temporal process of traffic flow and detecting traffic congestion are important issues associated with developing sustainable urban policies to resolve congestion. Therefore, the objective of this study is to propose a flow-based ranking algorithm for investigating traffic demands in terms of the attractiveness of street segments and flow complexity of the street network based on turning probability. Our results show that, by analyzing the topological characteristics of streets and volume data for a small fraction of street segments in Taipei City, the most congested segments of the city were identified successfully. The identified congested segments are significantly close to the potential congestion zones, including the officially announced most congested streets, the segments with slow moving speeds at rush hours, and the areas near significant landmarks. The identified congested segments also captured congestion-prone areas concentrated in the business districts and industrial areas of the city. Identifying the topological characteristics and flow complexity of traffic congestion provides network topological insights for sustainable urban planning, and these characteristics can be used to further understand congestion propagation.

  9. Simulation-based education: understanding the socio-cultural complexity of a surgical training 'boot camp'.

    Science.gov (United States)

    Cleland, Jennifer; Walker, Kenneth G; Gale, Michael; Nicol, Laura G

    2016-08-01

    The focus of simulation-based education (SBE) research has been limited to outcome and effectiveness studies. The effect of social and cultural influences on SBE is unclear and empirical work is lacking. Our objective in this study was to explore and understand the complexity of context and social factors at a surgical boot camp (BC). A rapid ethnographic study, employing the theoretical lenses of complexity and activity theory and Bourdieu's concept of 'capital', to better understand the socio-cultural influences acting upon, and during, two surgical BCs, and their implications for SBE. Over two 4-day BCs held in Scotland, UK, an observer and two preceptors conducted 81 hours of observations, 14 field interviews and 11 formal interviews with faculty members (n = 10, including the lead faculty member, session leaders and junior faculty members) and participants (n = 19 core surgical trainees and early-stage residents). Data collection and inductive analysis for emergent themes proceeded iteratively. This paper focuses on three analytical themes. First, the complexity of the surgical training system and wider health care education context, and how this influenced the development of the BC. Second, participants' views of the BC as a vehicle not just for learning skills but for gaining 'insider information' on how best to progress in surgical training. Finally, the explicit aim of faculty members to use the Scottish Surgical Bootcamp to welcome trainees and residents into the world of surgery, and how this occurred. To the best of our knowledge, this is the first empirical study of a surgical BC that takes a socio-cultural approach to exploring and understanding context, complexities, uncertainties and learning associated with one example of SBE. Our findings suggest that a BC is as much about social and cultural processes as it is about individual, cognitive and acquisitive learning. Acknowledging this explicitly will help those planning similar enterprises and

  10. A reduced complexity discrete particle model for understanding the sediment dynamics of steep upland river confluences

    Science.gov (United States)

    Tancock, M. J.; Lane, S. N.; Hardy, R. J.

    2012-12-01

    There has been a significant amount of research conducted in order to understand the flow fields at natural river confluences. Much of this has been made possible due to advances in the use of Computational Fluid Dynamics (CFD). However, much of this research has been conducted on river confluences with negligible water surface slopes and any understanding of the sediment dynamics is largely implied from the flow fields. Therefore, a key challenge is to understand the flow and sediment dynamics of steep river confluences with dynamic boundaries. Two numerical modelling developments are presented which together are capable of increasing our understanding of the sediment dynamics of steep river confluences. The first is the application of a Height-of-Liquid (HOL) model within a CFD framework to explicitly solve the water surface elevation. This is a time-dependent, multiphase treatment of the fluid dynamics which solves for the change in volume of water and air in each vertical column of the mesh. The second is the development of a reduced complexity discrete particle transport model which uses the change in momentum on a spherical particle to predict the transport paths through the flow field determined from CFD simulations. The performance of the two models is tested using field data from a series of highly dynamic, steep gravel-bed confluences on a braidplain of the Borgne d'Arolla, Switzerland. The HOL model is validated against the water surface elevation and flow velocity data and is demonstrated to provide a reliable representation of the flow field in fast-flowing, supercritical flows. In order to validate the discrete particle model, individual particles were tracked using electronic tacheometry. The model is demonstrated to accurately represent the particle tracks obtained in the field and provides a new methodology to understand the dynamic morphology of braid plains.

  11. Understanding and quantifying cognitive complexity level in mathematical problem solving items

    Directory of Open Access Journals (Sweden)

    SUSAN E. EMBRETSON

    2008-09-01

    Full Text Available The linear logistic test model (LLTM; Fischer, 1973 has been applied to a wide variety of new tests. When the LLTM application involves item complexity variables that are both theoretically interesting and empirically supported, several advantages can result. These advantages include elaborating construct validity at the item level, defining variables for test design, predicting parameters of new items, item banking by sources of complexity and providing a basis for item design and item generation. However, despite the many advantages of applying LLTM to test items, it has been applied less often to understand the sources of complexity for large-scale operational test items. Instead, previously calibrated item parameters are modeled using regression techniques because raw item response data often cannot be made available. In the current study, both LLTM and regression modeling are applied to mathematical problem solving items from a widely used test. The findings from the two methods are compared and contrasted for their implications for continued development of ability and achievement tests based on mathematical problem solving items.

  12. Applying a complex adaptive system's understanding of health to primary care [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Johannes Bircher

    2016-09-01

    Full Text Available This paper explores the diagnostic and therapeutic potential of a new concept of health. Investigations into the nature of health have led to a new definition that explains health as a complex adaptive system (CAS and is based on five components (a-e. Humans like all biological creatures must satisfactorily respond to (a the demands of life. For this purpose they need (b a biologically given potential (BGP and (c a personally acquired potential (PAP. These properties of individuals are embedded within (d social and (e environmental determinants of health. Between these five components of health there are 10 complex interactions that justify viewing health as a CAS. In each patient, the current state of health as a CAS evolved from the past, will move forward to a new future, and has to be analyzed and treated as an autonomous whole. A diagnostic procedure is suggested as follows: together with the patient, the five components and 10 complex interactions are assessed. This may help patients to better understand their situations and to recognize possible next steps that may be useful in order to evolve toward better health by themselves. In this process mutual trust in the patient-physician interaction is critical. The described approach offers new possibilities for helping patients improve their health prospects.

  13. Using a complex adaptive system lens to understand family caregiving experiences navigating the stroke rehabilitation system.

    Science.gov (United States)

    Ghazzawi, Andrea; Kuziemsky, Craig; O'Sullivan, Tracey

    2016-10-01

    Family caregivers provide the stroke survivor with social support and continuity during the transition home from a rehabilitation facility. In this exploratory study we examined family caregivers' perceptions and experiences navigating the stroke rehabilitation system. The theories of continuity of care and complex adaptive systems were integrated to examine the transition from a stroke rehabilitation facility to the patient's home. This study provides an understanding of the interacting complexities at the macro and micro levels. A convenient sample of family caregivers (n = 14) who provide care for a stroke survivor were recruited 4-12 weeks following the patient's discharge from a stroke rehabilitation facility in Ontario, Canada. Interviews were conducted with family caregivers to examine their perceptions and experiences navigating the stroke rehabilitation system. Directed and inductive content analysis and the theory of Complex Adaptive Systems were used to interpret the perceptions of family caregivers. Health system policies and procedures at the macro-level determined the types and timing of information being provided to caregivers, and impacted continuity of care and access to supports and services at the micro-level. Supports and services in the community, such as outpatient physiotherapy services, were limited or did not meet the specific needs of the stroke survivors or family caregivers. Relationships with health providers, informational support, and continuity in case management all influence the family caregiving experience and ultimately the quality of care for the stroke survivor, during the transition home from a rehabilitation facility.

  14. Grid-Free 2D Plasma Simulations of the Complex Interaction Between the Solar Wind and Small, Near-Earth Asteroids

    Science.gov (United States)

    Zimmerman, M. I.; Farrell, W. M.; Poppe, A. R.

    2014-01-01

    We present results from a new grid-free 2D plasma simulation code applied to a small, unmagnetized body immersed in the streaming solar wind plasma. The body was purposely modeled as an irregular shape in order to examine photoemission and solar wind plasma flow in high detail on the dayside, night-side, terminator and surface-depressed 'pocket' regions. Our objective is to examine the overall morphology of the various plasma interaction regions that form around a small body like a small near-Earth asteroid (NEA). We find that the object obstructs the solar wind flow and creates a trailing wake region downstream, which involves the interplay between surface charging and ambipolar plasma expansion. Photoemission is modeled as a steady outflow of electrons from illuminated portions of the surface, and under direct illumination the surface forms a non-monotonic or ''double-sheath'' electric potential upstream of the body, which is important for understanding trajectories and equilibria of lofted dust grains in the presence of a complex asteroid geometry. The largest electric fields are found at the terminators, where ambipolar plasma expansion in the body-sized night-side wake merges seamlessly with the thin photoelectric sheath on the dayside. The pocket regions are found to be especially complex, with nearby sunlit regions of positive potential electrically connected to unlit negative potentials and forming adjacent natural electric dipoles. For objects near the surface, we find electrical dissipation times (through collection of local environmental solar wind currents) that vary over at least 5 orders of magnitude: from 39 Micro(s) inside the near-surface photoelectron cloud under direct sunlight to less than 1 s inside the particle-depleted night-side wake and shadowed pocket regions

  15. The Crucible simulation: Behavioral simulation improves clinical leadership skills and understanding of complex health policy change.

    Science.gov (United States)

    Cohen, Daniel; Vlaev, Ivo; McMahon, Laurie; Harvey, Sarah; Mitchell, Andy; Borovoi, Leah; Darzi, Ara

    2017-05-11

    The Health and Social Care Act 2012 represents the most complex National Health Service reforms in history. High-quality clinical leadership is important for successful implementation of health service reform. However, little is known about the effectiveness of current leadership training. This study describes the use of a behavioral simulation to improve the knowledge and leadership of a cohort of medical doctors expected to take leadership roles in the National Health Service. A day-long behavioral simulation (The Crucible) was developed and run based on a fictitious but realistic health economy. Participants completed pre- and postsimulation questionnaires generating qualitative and quantitative data. Leadership skills, knowledge, and behavior change processes described by the "theory of planned behavior" were self-assessed pre- and postsimulation. Sixty-nine medical doctors attended. Participants deemed the simulation immersive and relevant. Significant improvements were shown in perceived knowledge, capability, attitudes, subjective norms, intentions, and leadership competency following the program. Nearly one third of participants reported that they had implemented knowledge and skills from the simulation into practice within 4 weeks. This study systematically demonstrates the effectiveness of behavioral simulation for clinical management training and understanding of health policy reform. Potential future uses and strategies for analysis are discussed. High-quality care requires understanding of health systems and strong leadership. Policymakers should consider the use of behavioral simulation to improve understanding of health service reform and development of leadership skills in clinicians, who readily adopt skills from simulation into everyday practice.

  16. Lattice wave transport in a 2D complex plasma graphene analogue

    Science.gov (United States)

    Kostadinova, Eva; Liaw, Constanze; Matthews, Lorin; Busse, Kyle; Hyde, Truell

    2017-10-01

    We present a numerical study of Anderson localization in a2D complex plasma crystal. In the classical regime, Anderson localization is the absence of diffusion of certain wave frequencies due to scattering from lattice defects. The appropriate condition for localization is (known as the modified Ioffe-Regel criterion), where is the wavevector and is the mean free path. As, the wave cannot perform even a single oscillation between successive interactions with defects, which eliminates the propagation. Here we examine transport of in-plane lattice waves through a 2D dusty plasma crystal, which is used as a graphene analogue. The lattice disorder is controlled in two ways: i) through variation of particle size (and thus particle density and interparticle separation) and ii) through variation of the radial confinement force. This allows us to compare the transport properties of the crystal in the weak and strong interaction regimes, which provides valuable information on the effects of strong interactions in the crystal. NSF & NASA funding is gratefully acknowledged.

  17. Gibberellin DELLA signaling targets the retromer complex to redirect protein trafficking to the plasma membrane.

    Science.gov (United States)

    Salanenka, Yuliya; Verstraeten, Inge; Löfke, Christian; Tabata, Kaori; Naramoto, Satoshi; Glanc, Matouš; Friml, Jiří

    2018-02-20

    The plant hormone gibberellic acid (GA) is a crucial regulator of growth and development. The main paradigm of GA signaling puts forward transcriptional regulation via the degradation of DELLA transcriptional repressors. GA has also been shown to regulate tropic responses by modulation of the plasma membrane incidence of PIN auxin transporters by an unclear mechanism. Here we uncovered the cellular and molecular mechanisms by which GA redirects protein trafficking and thus regulates cell surface functionality. Photoconvertible reporters revealed that GA balances the protein traffic between the vacuole degradation route and recycling back to the cell surface. Low GA levels promote vacuolar delivery and degradation of multiple cargos, including PIN proteins, whereas high GA levels promote their recycling to the plasma membrane. This GA effect requires components of the retromer complex, such as Sorting Nexin 1 (SNX1) and its interacting, microtubule (MT)-associated protein, the Cytoplasmic Linker-Associated Protein (CLASP1). Accordingly, GA regulates the subcellular distribution of SNX1 and CLASP1, and the intact MT cytoskeleton is essential for the GA effect on trafficking. This GA cellular action occurs through DELLA proteins that regulate the MT and retromer presumably via their interaction partners Prefoldins (PFDs). Our study identified a branching of the GA signaling pathway at the level of DELLA proteins, which, in parallel to regulating transcription, also target by a nontranscriptional mechanism the retromer complex acting at the intersection of the degradation and recycling trafficking routes. By this mechanism, GA can redirect receptors and transporters to the cell surface, thus coregulating multiple processes, including PIN-dependent auxin fluxes during tropic responses. Copyright © 2018 the Author(s). Published by PNAS.

  18. Measurement of the speed of sound by observation of the Mach cones in a complex plasma under microgravity conditions

    Energy Technology Data Exchange (ETDEWEB)

    Zhukhovitskii, D. I., E-mail: dmr@ihed.ras.ru; Fortov, V. E.; Molotkov, V. I.; Lipaev, A. M.; Naumkin, V. N. [Joint Institute of High Temperatures, Russian Academy of Sciences, Izhorskaya 13, Bd. 2, 125412 Moscow (Russian Federation); Thomas, H. M. [Research Group Complex Plasma, DLR, Oberpfaffenhofen, 82234 Wessling (Germany); Ivlev, A. V.; Morfill, G. E. [Max-Planck-Institut für extraterrestrische Physik, Giessenbachstrasse, 85748 Garching (Germany); Schwabe, M. [Department of Chemical and Biomolecular Engineering, Graves Lab, D75 Tan Hall, University of California, Berkeley, CA 94720 (United States)

    2015-02-15

    We report the first observation of the Mach cones excited by a larger microparticle (projectile) moving through a cloud of smaller microparticles (dust) in a complex plasma with neon as a buffer gas under microgravity conditions. A collective motion of the dust particles occurs as propagation of the contact discontinuity. The corresponding speed of sound was measured by a special method of the Mach cone visualization. The measurement results are incompatible with the theory of ion acoustic waves. The estimate for the pressure in a strongly coupled Coulomb system and a scaling law for the complex plasma make it possible to derive an evaluation for the speed of sound, which is in a reasonable agreement with the experiments in complex plasmas.

  19. The major histocompatibility complex: a model for understanding graft-versus-host disease.

    Science.gov (United States)

    Petersdorf, Effie W

    2013-09-12

    Acute graft-versus-host disease (GVHD) afflicts as much as 80% of all patients who receive an unrelated donor hematopoietic cell transplant (HCT) for the treatment of blood disorders, even with optimal donor HLA matching and use of prophylactic immunosuppressive agents. Of patients who develop acute GVHD, many are at risk for chronic GVHD and bear the burden of considerable morbidity and lowered quality of life years after transplantation. The immunogenetic basis of GVHD has been the subject of intensive investigation, with the classic HLA genetic loci being the best-characterized determinants. Recent information on the major histocompatibility complex (MHC) region of chromosome 6 as an important source of untyped genetic variation has shed light on novel GVHD determinants. These data open new paradigms for understanding the genetic basis of GVHD.

  20. Dielectric barrier discharges: progress on plasma sources and on the understanding of regimes and single filaments

    Science.gov (United States)

    Brandenburg, Ronny

    2017-05-01

    Dielectric barrier discharges (DBDs) are plasmas generated in configurations with an insulating (dielectric) material between the electrodes which is responsible for a self-pulsing operation. DBDs are a typical example of nonthermal atmospheric or normal pressure gas discharges. Initially used for the generation of ozone, they have opened up many other fields of application. Therefore DBDs are a relevant tool in current plasma technology as well as an object for fundamental studies. Another motivation for further research is the fact that so-called partial discharges in insulated high voltage systems are special types of DBDs. The breakdown processes, the formation of structures, and the role of surface processes are currently under investigation. This review is intended to give an update to the already existing literature on DBDs considering the research and development within the last two decades. The main principles and different modes of discharge generation are summarized. A collection of known as well as special electrode configurations and reactor designs will be presented. This shall demonstrate the different and broad possibilities, but also the similarities and common aspects of devices for different fields of applications explored within the last years. The main part is devoted to the progress on the investigation of different aspects of breakdown and plasma formation with the focus on single filaments or microdischarges. This includes a summary of the current knowledge on the electrical characterization of filamentary DBDs. In particular, the recent new insights on the elementary volume and surface memory mechanisms in these discharges will be discussed. An outlook for the forthcoming challenges on research and development will be given.

  1. Computational Cellular Dynamics Based on the Chemical Master Equation: A Challenge for Understanding Complexity

    Science.gov (United States)

    Liang, Jie; Qian, Hong

    2010-01-01

    Modern molecular biology has always been a great source of inspiration for computational science. Half a century ago, the challenge from understanding macromolecular dynamics has led the way for computations to be part of the tool set to study molecular biology. Twenty-five years ago, the demand from genome science has inspired an entire generation of computer scientists with an interest in discrete mathematics to join the field that is now called bioinformatics. In this paper, we shall lay out a new mathematical theory for dynamics of biochemical reaction systems in a small volume (i.e., mesoscopic) in terms of a stochastic, discrete-state continuous-time formulation, called the chemical master equation (CME). Similar to the wavefunction in quantum mechanics, the dynamically changing probability landscape associated with the state space provides a fundamental characterization of the biochemical reaction system. The stochastic trajectories of the dynamics are best known through the simulations using the Gillespie algorithm. In contrast to the Metropolis algorithm, this Monte Carlo sampling technique does not follow a process with detailed balance. We shall show several examples how CMEs are used to model cellular biochemical systems. We shall also illustrate the computational challenges involved: multiscale phenomena, the interplay between stochasticity and nonlinearity, and how macroscopic determinism arises from mesoscopic dynamics. We point out recent advances in computing solutions to the CME, including exact solution of the steady state landscape and stochastic differential equations that offer alternatives to the Gilespie algorithm. We argue that the CME is an ideal system from which one can learn to understandcomplex behavior” and complexity theory, and from which important biological insight can be gained. PMID:24999297

  2. Advanced Fluorescence Microscopy Approaches to Understand the Dynamic Organization of the Plasma Membrane in Eukaryotes

    DEFF Research Database (Denmark)

    Ziomkiewicz, Iwona

    signaling in plants. Furthermore, it was established that ENODL9 clustering affects the organization of the PM and distribution of other PM proteins. Analysis of the phenotype of mutant lines revealed that ENODL9 has an important role for plant development and the adaptation to osmotic stress. This resulted......The plasma membrane (PM) is a physical barrier that defines the boundaries of a cell. It not only isolates the cell interior from the environment, but also enables cell communication and a selective exchange of solutes. To serve those contrasting functions, the PM has a dynamic structure consisting...

  3. Venom Resistance as a Model for Understanding the Molecular Basis of Complex Coevolutionary Adaptations.

    Science.gov (United States)

    Holding, Matthew L; Drabeck, Danielle H; Jansa, Sharon A; Gibbs, H Lisle

    2016-11-01

    SynopsisVenom and venom resistance are molecular phenotypes widely considered to have diversified through coevolution between predators and prey. However, while evolutionary and functional studies on venom have been extensive, little is known about the molecular basis, variation, and complexity of venom resistance. We review known mechanisms of venom resistance and relate these mechanisms to their predicted impact on coevolutionary dynamics with venomous enemies. We then describe two conceptual approaches which can be used to examine venom/resistance systems. At the intraspecific level, tests of local adaptation in venom and resistance phenotypes can identify the functional mechanisms governing the outcomes of coevolution. At deeper evolutionary timescales, the combination of phylogenetically informed analyses of protein evolution coupled with studies of protein function promise to elucidate the mode and tempo of evolutionary change on potentially coevolving genes. We highlight case studies that use each approach to extend our knowledge of these systems as well as address larger questions about coevolutionary dynamics. We argue that resistance and venom are phenotypic traits which hold exceptional promise for investigating the mechanisms, dynamics, and outcomes of coevolution at the molecular level. Furthermore, extending the understanding of single gene-for-gene interactions to the whole resistance and venom phenotypes may provide a model system for examining the molecular and evolutionary dynamics of complex multi-gene interactions. © The Author 2016. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

  4. The Nevada Rural Ozone Initiative (NVROI): Insights to understanding air pollution in complex terrain.

    Science.gov (United States)

    Gustin, Mae Sexauer; Fine, Rebekka; Miller, Matthieu; Jaffe, Dan; Burley, Joel

    2015-10-15

    The Nevada Rural Ozone Initiative (NVROI) was established to better understand O3 concentrations in the Western United States (US). The major working hypothesis for development of the sampling network was that the sources of O3 to Nevada are regional and global. Within the framework of this overarching hypothesis, we specifically address two conceptual meteorological hypotheses: (1) The high elevation, complex terrain, and deep convective mixing that characterize Nevada, make this state ideally located to intercept polluted parcels of air transported into the US from the free troposphere; and (2) site specific terrain features will influence O3 concentrations observed at surface sites. Here, the impact of complex terrain and site location on observations are discussed. Data collected in Nevada at 6 sites (1385 to 2082 m above sea level (asl)) are compared with that collected at high elevation sites in Yosemite National Park and the White Mountains, California. Average daily maximum 1-hour concentrations of O3 during the first year of the NVROI ranged from 58 to 69 ppbv (spring), 53 to 62 ppbv (summer), 44 to 49 ppbv (fall), and 37 to 45 ppbv (winter). These were similar to those measured at 3 sites in Yosemite National Park (2022 to 3031 m asl), and at 4 sites in the White Mountains (1237 to 4342 m asl) (58 to 67 ppbv (summer) and 47 to 58 ppbv (fall)). Results show, that in complex terrain, collection of data should occur at high and low elevation sites to capture surface impacts, and site location with respect to topography should be considered. Additionally, concentrations measured are above the threshold reported for causing a reduction in growth and visible injury for plants (40 ppbv), and sustained exposure at high elevation locations in the Western USA may be detrimental for ecosystems. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Understanding Student Cognition about Complex Earth System Processes Related to Climate Change

    Science.gov (United States)

    McNeal, K. S.; Libarkin, J.; Ledley, T. S.; Dutta, S.; Templeton, M. C.; Geroux, J.; Blakeney, G. A.

    2011-12-01

    The Earth's climate system includes complex behavior and interconnections with other Earth spheres that present challenges to student learning. To better understand these unique challenges, we have conducted experiments with high-school and introductory level college students to determine how information pertaining to the connections between the Earth's atmospheric system and the other Earth spheres (e.g., hydrosphere and cryosphere) are processed. Specifically, we include psychomotor tests (e.g., eye-tracking) and open-ended questionnaires in this research study, where participants were provided scientific images of the Earth (e.g., global precipitation and ocean and atmospheric currents), eye-tracked, and asked to provide causal or relational explanations about the viewed images. In addition, the students engaged in on-line modules (http://serc.carleton.edu/eslabs/climate/index.html) focused on Earth system science as training activities to address potential cognitive barriers. The developed modules included interactive media, hands-on lessons, links to outside resources, and formative assessment questions to promote a supportive and data-rich learning environment. Student eye movements were tracked during engagement with the materials to determine the role of perception and attention on understanding. Students also completed a conceptual questionnaire pre-post to determine if these on-line curriculum materials assisted in their development of connections between Earth's atmospheric system and the other Earth systems. The pre-post results of students' thinking about climate change concepts, as well as eye-tracking results, will be presented.

  6. Understanding the energetics of magnetic reconnection with the presence of waves in laboratory plasmas

    Science.gov (United States)

    Yamada, M.; Yoo, J.; Ji, H.; Jara-Almonte, J.; Fox, W.; Kulsrud, R. M.

    2017-12-01

    In spite of the huge difference (106-107) in physical scales, we find remarkable commonality between the properties and the dynamics of the collisionless reconnection layer in laboratory and space plasmas. The recent significant progress in diagnostics in the both fields made us possible to directly compare the observed physics processes. At first experimental results on the energy conversion and partitioning are discussed and compared with quantitative estimates based on two-fluid analysis as well as space observations. We observed notable similarity in the energy partitioning in the reconnection layer of the MRX results and space observations [1,2]. Furthermore, we have observed whistler waves and lower-hybrid frequency fluctuations at the lower density side of asymmetric reconnection layer on MRX [2]. The experimental results are remarkably consistent with the recent space observations from MMS [3]. We plan to systematically vary the guide field strength to critically test the validity and universality of plasma waves and their consequences on the energy dissipation to electrons. We directly compare the data from the MRX and the recent MMS observations which show very similar power spectra. Ref.: [1] M. Yamada, et al, PoP 23, 055402 (2016), [2] J. Yoo et al, in press J. G.R. (2017), [3] L. J. Chen et al, tom be published.

  7. Understanding the Complexities of Communicating Management Decisions on the Subsistence Use of Yukon River Salmon

    Science.gov (United States)

    Brooks, J. F.; Trainor, S.

    2017-12-01

    Over 20,000 residents in Alaska and Yukon Territory rely upon the Yukon River to provide them harvests of Pacific salmon each year. Salmon are a highly valued food resource and the practice of salmon fishing along the Yukon is deep rooted in local cultures and traditions. Potential future impacts of climate change on the health of Yukon River salmon stocks could be significant. Collaborative managerial processes which incorporate the viewpoints of subsistence stakeholders will be crucial in enabling communities and managerial institutions to adapt and manage these impacts. However, the massive extent of the Yukon River makes it difficult for communities rich with highly localized knowledge to situate themselves within a drainage-wide context of resource availability, and to fully understand the implications that management decisions may have for their harvest. Differences in salmon availability and abundance between the upper and lower Yukon, commercial vs. subsistence fishery interests, and enforcement of the international Pacific Salmon Treaty further complicate understanding and makes the topic of salmon as a subsistence resource a highly contentious issue. A map which synthesizes the presence and absence of Pacific salmon throughout the entire Yukon River drainage was requested by both subsistence fishers and natural resource managers in Alaska in order to help facilitate productive conversations about salmon management decisions. Interviews with Alaskan stakeholders with managerial, biological, and subsistence harvest backgrounds were carried out and a literature review was conducted in order to understand what such a map should and could accomplish. During the research process, numerous data gaps concerning the distribution of salmon along the Yukon River were discovered, and insights about the complexities involved in translating science when it is situated within a charged political, economic, and cultural context were revealed. Preliminary maps depicting

  8. Measuring spatial patterns in floodplains: A step towards understanding the complexity of floodplain ecosystems: Chapter 6

    Science.gov (United States)

    Scown, Murray W.; Thoms, Martin C.; DeJager, Nathan R.; Gilvear, David J.; Greenwood, Malcolm T.; Thoms, Martin C.; Wood, Paul J.

    2016-01-01

    Floodplains can be viewed as complex adaptive systems (Levin, 1998) because they are comprised of many different biophysical components, such as morphological features, soil groups and vegetation communities as well as being sites of key biogeochemical processing (Stanford et al., 2005). Interactions and feedbacks among the biophysical components often result in additional phenomena occuring over a range of scales, often in the absence of any controlling factors (sensu Hallet, 1990). This emergence of new biophysical features and rates of processing can lead to alternative stable states which feed back into floodplain adaptive cycles (cf. Hughes, 1997; Stanford et al., 2005). Interactions between different biophysical components, feedbacks, self emergence and scale are all key properties of complex adaptive systems (Levin, 1998; Phillips, 2003; Murray et al., 2014) and therefore will influence the manner in which we study and view spatial patterns. Measuring the spatial patterns of floodplain biophysical components is a prerequisite to examining and understanding these ecosystems as complex adaptive systems. Elucidating relationships between pattern and process, which are intrinsically linked within floodplains (Ward et al., 2002), is dependent upon an understanding of spatial pattern. This knowledge can help river scientists determine the major drivers, controllers and responses of floodplain structure and function, as well as the consequences of altering those drivers and controllers (Hughes and Cass, 1997; Whited et al., 2007). Interactions and feedbacks between physical, chemical and biological components of floodplain ecosystems create and maintain a structurally diverse and dynamic template (Stanford et al., 2005). This template influences subsequent interactions between components that consequently affect system trajectories within floodplains (sensu Bak et al., 1988). Constructing and evaluating models used to predict floodplain ecosystem responses to

  9. Bringing content understanding into usability testing in complex application domains—a case study in eHealth

    DEFF Research Database (Denmark)

    Andersen, Simon Bruntse; Rasmussen, Claire Kirchert; Frøkjær, Erik

    2017-01-01

    A usability evaluation technique, Cooperative Usability Testing with Questions of Understanding (CUT with QU) intended to illuminate users’ ability to understand the content information of an application is proposed. In complex application domains as for instance the eHealth domain, this issue...... of users’ content understanding is sometimes crucial, and thus should be carefully evaluated. Unfortunately, conventional usability evaluation techniques do not address challenges of content understanding. In a case study within eHealth, specifically the setting of a rehabilitation clinic involving...... the participation of four physiotherapists and four clients in a period of 3.5 months, it was demonstrated how CUT with QU can complement conventional usability testing and provide insight into users’ challenges with understanding of a new complex eHealth application. More experiments in other complex application...

  10. Understanding Transient Forcing with Plasma Instability Model, Ionospheric Propagation Model and GNSS Observations

    Science.gov (United States)

    Deshpande, K.; Zettergren, M. D.; Datta-Barua, S.

    2017-12-01

    Fluctuations in the Global Navigation Satellite Systems (GNSS) signals observed as amplitude and phase scintillations are produced by plasma density structures in the ionosphere. Phase scintillation events in particular occur due to structures at Fresnel scales, typically about 250 meters at ionospheric heights and GNSS frequency. Likely processes contributing to small-scale density structuring in auroral and polar regions include ionospheric gradient-drift instability (GDI) and Kelvin-Helmholtz instability (KHI), which result, generally, from magnetosphere-ionosphere interactions (e.g. reconnection) associated with cusp and auroral zone regions. Scintillation signals, ostensibly from either GDI or KHI, are frequently observed in the high latitude ionosphere and are potentially useful diagnostics of how energy from the transient forcing in the cusp or polar cap region cascades, via instabilities, to small scales. However, extracting quantitative details of instabilities leading to scintillation using GNSS data drastically benefits from both a model of the irregularities and a model of GNSS signal propagation through irregular media. This work uses a physics-based model of the generation of plasma density irregularities (GEMINI - Geospace Environment Model of Ion-Neutral Interactions) coupled to an ionospheric radio wave propagation model (SIGMA - Satellite-beacon Ionospheric-scintillation Global Model of the upper Atmosphere) to explore the cascade of density structures from medium to small (sub-kilometer) scales. Specifically, GEMINI-SIGMA is used to simulate expected scintillation from different instabilities during various stages of evolution to determine features of the scintillation that may be useful to studying ionospheric density structures. Furthermore we relate the instabilities producing GNSS scintillations to the transient space and time-dependent magnetospheric phenomena and further predict characteristics of scintillation in different geophysical

  11. High School Students' Understanding of Change over Time and System Complexity: A Focus on the Cryosphere

    Science.gov (United States)

    McNeal, K. S.; Libarkin, J.; Ledley, T. S.; Guthrie, C.

    2010-12-01

    Most students have difficulty articulating processes that are key for Earth’s changes and may have limited ability to understand Earth system science and think across spatial and temporal dimensions. The cryosphere, a complex and dynamic Earth system that exhibits change over time (e.g., seasonal, yearly, decadal, and millennial), can be difficult for students to reason about. The presented research assesses the effectiveness of the project developed on-line modules on high school students’ cryosphere content knowledge and skill development, including their: (1) conceptual understanding of ice, thermodynamics, climate, changes in ice cover over time, Earth system interactions, and complexity, and (2) use and interpretation of data and graphs about the cryosphere. Pre- and post- student assessments, classroom observations, and teacher interviews were collected from four high school classrooms in Texas to determine the effectiveness of the Earthlabs cryosphere modules in reaching the specified learning goals. Preliminary analysis of pre-and post-test data revealed a number of interesting changes where students displayed an increase in their awareness of the cryosphere, increase in confidence about cryosphere knowledge, and an increase in their ability to read and interpret graphs. Furthermore, classroom observations made for 25 minutes during a class period illustrated that for over 84% of the class period the students were engaged with the Earthlabs materials and spent the majority (>50%) of their time either discussing (31%) or working on the on-line Earthlabs cryosphere materials (29%). Finally, forty-five minute individual telephone interviews conducted with the four implementing cryosphere teachers revealed that teachers overwhelmingly reflected that the materials supported students’ ability to learn about the (i) nature and importance of the cryosphere, (ii) manipulation, analysis, interpretation of data, (iii) physical changes over multiple time scales

  12. Plasma levels of nucleosomes and nucleosome-autoantibody complexes in murine lupus: effects of disease progression and lipopolyssacharide administration.

    NARCIS (Netherlands)

    Licht, R.; Bruggen, M.C.J. van; Oppers-Walgreen, B.; Rijke, T.P.M.; Berden, J.H.M.

    2001-01-01

    OBJECTIVE: To evaluate the effect of disease progression and lipopolysaccharide (LPS) administration on the presence of nucleosomes, antinucleosome reactivity, and nucleosome-Ig complexes in the circulation of MRL and control mice. METHODS: Plasma samples from lupus-prone (MRL/lpr and MRL/+) and

  13. Plasma-treated poly(ethylene oxide) nanofibers containing tea tree oil/beta-cyclodextrin inclusion complex for antibacterial packaging.

    Science.gov (United States)

    Cui, Haiying; Bai, Mei; Lin, Lin

    2018-01-01

    This work describes the effect of cold nitrogen plasma to enhance the antibacterial activity of poly(ethylene oxide) (PEO) nanofibers containing antibacterial agent. Beta-cyclodextrin (β-CD) and tea tree oil (TTO) were used as a host-guest to form water-soluble inclusion complex. The encapsulation efficiency of TTO in inclusion complex could reach 73.23% at 60°C. As antibacterial agent, the inclusion complex was encapsulated into PEO matrix by electrospun. After plasma treatment, the release efficiency of antibacterial agent from PEO nanofibers was improved. As a result, the antibacterial activity of PEO nanofibers was enhanced accordingly. The plasma-treated nanofiber membranes achieved the highest antibacterial activity against Escherichia coli O157:H7, which was tested on the beef for 7d, with inhibition efficiently of 99.99% whether at 4°C or 12°C. The plasma-treated PEO nanofiber membranes containing TTO/β-CD inclusion complex (TTO/β-CD-IC) can prolong the shelf-life of beef, suggesting it has potential application in active food packaging. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. A lignan complex isolated from flaxseed does not affect plasma lipid concentrations or antioxidant capacity in healthy postmenopausal women

    DEFF Research Database (Denmark)

    Hallund, Jesper; Ravn-Haren, Gitte; Bügel, S.

    2006-01-01

    A lignan complex rich in the plant lignan secoisolariciresinol diglucoside (SDG) was isolated from flaxseed. SDG is metabolized by the colonic microflora to the mammalian lignans enterodiol (END) and enterolactone (ENL), and was hypothesized to reduce plasma lipid concentrations and improve...

  15. Millimeter-wave imaging of magnetic fusion plasmas: technology innovations advancing physics understanding

    Science.gov (United States)

    Wang, Y.; Tobias, B.; Chang, Y.-T.; Yu, J.-H.; Li, M.; Hu, F.; Chen, M.; Mamidanna, M.; Phan, T.; Pham, A.-V.; Gu, J.; Liu, X.; Zhu, Y.; Domier, C. W.; Shi, L.; Valeo, E.; Kramer, G. J.; Kuwahara, D.; Nagayama, Y.; Mase, A.; Luhmann, N. C., Jr.

    2017-07-01

    Electron cyclotron emission (ECE) imaging is a passive radiometric technique that measures electron temperature fluctuations; and microwave imaging reflectometry (MIR) is an active radar imaging technique that measures electron density fluctuations. Microwave imaging diagnostic instruments employing these techniques have made important contributions to fusion science and have been adopted at major fusion facilities worldwide including DIII-D, EAST, ASDEX Upgrade, HL-2A, KSTAR, LHD, and J-TEXT. In this paper, we describe the development status of three major technological advancements: custom mm-wave integrated circuits (ICs), digital beamforming (DBF), and synthetic diagnostic modeling (SDM). These have the potential to greatly advance microwave fusion plasma imaging, enabling compact and low-noise transceiver systems with real-time, fast tracking ability to address critical fusion physics issues, including ELM suppression and disruptions in the ITER baseline scenario, naturally ELM-free states such as QH-mode, and energetic particle confinement (i.e. Alfvén eigenmode stability) in high-performance regimes that include steady-state and advanced tokamak scenarios. Furthermore, these systems are fully compatible with today’s most challenging non-inductive heating and current drive systems and capable of operating in harsh environments, making them the ideal approach for diagnosing long-pulse and steady-state tokamaks.

  16. Toward a better understanding of the complex geochemical processes governing subsurface contaminant transport

    International Nuclear Information System (INIS)

    Puls, R.W.

    1990-01-01

    Identification and understanding of the geochemical processes, including ion exchange, precipitation, organic partitioning, chemisorption, aqueous complexation, and colloidal stability and transport, controlling subsurface contamination is essential for making accurate predictions of the fate and transport of these constituents. Current approaches to quantify the effect of these processes primarily involve laboratory techniques, including the use of closed static systems (batch experiments) where small amounts of aquifer solids or minerals are contacted with an aqueous phase containing the components of interest for relatively short durations; and dynamic systems (column experiments) where a larger segment of the aquifer is investigated by analyzing the breakthrough profiles of reactive and non-reactive species. Both approaches are constrained by differences in scale, alteration of media during sample collection and use, and spatial variability. More field reactivity studies are needed to complement established laboratory approaches for the determination of retardation factors and scaling factors, corroboration of batch and column results, and validation of sampling techniques. These studies also serve to accentuate areas of geochemical process research where data deficiencies exist, such as the kinetics of adsorption-desorption, metal-organic-mineral interactions, and colloidal mobility. The advantages and disadvantages of the above approaches are discussed in the context of achieving a more completely integrated approach to geochemical transport experiments, with supportive data presented from selected studies. (Author) (16 refs., 4 figs., 2 tabs.)

  17. Understanding Epistatic Interactions between Genes Targeted by Non-coding Regulatory Elements in Complex Diseases

    Directory of Open Access Journals (Sweden)

    Min Kyung Sung

    2014-12-01

    Full Text Available Genome-wide association studies have proven the highly polygenic architecture of complex diseases or traits; therefore, single-locus-based methods are usually unable to detect all involved loci, especially when individual loci exert small effects. Moreover, the majority of associated single-nucleotide polymorphisms resides in non-coding regions, making it difficult to understand their phenotypic contribution. In this work, we studied epistatic interactions associated with three common diseases using Korea Association Resource (KARE data: type 2 diabetes mellitus (DM, hypertension (HT, and coronary artery disease (CAD. We showed that epistatic single-nucleotide polymorphisms (SNPs were enriched in enhancers, as well as in DNase I footprints (the Encyclopedia of DNA Elements [ENCODE] Project Consortium 2012, which suggested that the disruption of the regulatory regions where transcription factors bind may be involved in the disease mechanism. Accordingly, to identify the genes affected by the SNPs, we employed whole-genome multiple-cell-type enhancer data which discovered using DNase I profiles and Cap Analysis Gene Expression (CAGE. Assigned genes were significantly enriched in known disease associated gene sets, which were explored based on the literature, suggesting that this approach is useful for detecting relevant affected genes. In our knowledge-based epistatic network, the three diseases share many associated genes and are also closely related with each other through many epistatic interactions. These findings elucidate the genetic basis of the close relationship between DM, HT, and CAD.

  18. Complexities in Understanding Attentional Functioning among Children with Fetal Alcohol Spectrum Disorder

    Directory of Open Access Journals (Sweden)

    Kimberly eLane

    2014-03-01

    Full Text Available Parental reports of attention problems and clinical symptomatology of ADHD among children with fetal alcohol syndrome disorder (FASD were assessed in relation to performance on standardized subtests of attantional control/shifting and selective attention from the Test of Everyday Attention for Children (TEA-Ch; Manly et al., 1998. The participants included 14 children with FASD with a mean CA of 11.7 years and a mean MA of 9.7 years, and 14 typically developing (TD children with no reported history of prenatal exposure to alcohol or attention problems with a mean CA of 8.4 years and a mean MA of 9.6 years. The children with FASD were rated by their caregivers as having clinically significant attention difficulties for their developmental age. The reported symptomatology for the majority of the children with FASD were consistent with a diagnosis of ADHD, combined type, and only one child had a score within the average range. These reports are consistent with the finding here that the children with FASD demonstrated difficulties on the Creature Counting subtest of attentional control/shifting, but inconsistent with the finding that they outperformed the TD children on the Map Mission subtest of selective attention. These findings are considered within the context of the complexity in understanding attentional functioning among children with FASD and discrepancies across sources of information and components of attention.

  19. Understanding Immune Resistance to Infectious Bronchitis Using Major Histocompatibility Complex Chicken Lines.

    Science.gov (United States)

    da Silva, A P; Hauck, R; Zhou, H; Gallardo, R A

    2017-09-01

    Genetic resistance or susceptibility to infectious diseases has been largely associated with the avian major histocompatibility complex (MHC) genes. Our goal was to determine resistance and susceptibility of MHC B haplotype in congenic and inbred chicken lines in order to establish a resistant-susceptible model. Eight congenic lines (253/B18, 254/B15, 330/B21, 312/B24, 331/B2, 335/B19, 336/B21, and 342/BO), two inbred lines (003/B17 and 077/B19), and three commercial lines (white leghorn, brown layers, and broilers) were used in two experiments. We analyzed and compared immunologic responses and the effect of challenge by measuring viral load, IgG and IgA humoral responses, histopathology and histomorphometry, clinical signs, and immune cell populations in the different MHC B haplotype lines. We found that respiratory signs, tracheal deciliation and inflammation, airsacculitis, viral shedding in tears, and local humoral responses were good parameters to determine resistance or susceptibility. Based on these results, we identified 331/B2 as the most resistant and 335/B19 as the most susceptible congenic chicken lines. These two lines will be used as an animal model in subsequent experiments to understand the mechanisms by which the immune system in chickens generates resistance to infectious bronchitis virus.

  20. Initial observations of fine plasma structures at the flank magnetopause with the complex plasma analyzer SCA-1 onboard the Interball Tail Probe

    Directory of Open Access Journals (Sweden)

    O. L. Vaisberg

    Full Text Available The fast plasma analyzer EU-1 of the SCA-1 complex plasma spectrometer is installed onboard the Interball Tail Probe (Interball-1. It provides fast three-dimensional measurements of the ion distribution function on the low-spin-rate Prognoz satellite (about 2min. The EU-1 ion spectrometer with virtual aperture consists of two detectors with 16 E/Q narrow-angle analyzers and electrostatic scanners. This configuration allows one to measure the ion distribution function in three dimensions (over 15 energy steps in 50 eV/Q–5.0 keV/Q energy range in 64 directions in 7.5 s, which makes it independent of the slow rotation speed of the satellite. A description of the instrument and its capabilities is given. We present here the preliminary results of measurements of ions for two cases of the dawn low- and mid-latitude magnetopause crossings. The properties of observed ion structures and their tentative explanation are presented. The 12 September 1995 pass at low latitude at about 90° solar-zenith angle on the dawn side of the magnetosphere is considered in more detail. Dispersive ions are seen at the edge of the magnetopause and at the edges of subsequently observed plasma structures. Changes in ion velocity distribution in plasma structures observed after the first magnetopause crossing suggest that what resembles multiple magnetopause crossings may be plasma blobs penetrating the magnetosphere. Observed variations of plasma parameters near magnetopause structures suggest nonstationary reconnection as the most probable mechanism for observed structures.

  1. Initial observations of fine plasma structures at the flank magnetopause with the complex plasma analyzer SCA-1 onboard the Interball Tail Probe

    Directory of Open Access Journals (Sweden)

    O. L. Vaisberg

    1997-05-01

    Full Text Available The fast plasma analyzer EU-1 of the SCA-1 complex plasma spectrometer is installed onboard the Interball Tail Probe (Interball-1. It provides fast three-dimensional measurements of the ion distribution function on the low-spin-rate Prognoz satellite (about 2min. The EU-1 ion spectrometer with virtual aperture consists of two detectors with 16 E/Q narrow-angle analyzers and electrostatic scanners. This configuration allows one to measure the ion distribution function in three dimensions (over 15 energy steps in 50 eV/Q–5.0 keV/Q energy range in 64 directions in 7.5 s, which makes it independent of the slow rotation speed of the satellite. A description of the instrument and its capabilities is given. We present here the preliminary results of measurements of ions for two cases of the dawn low- and mid-latitude magnetopause crossings. The properties of observed ion structures and their tentative explanation are presented. The 12 September 1995 pass at low latitude at about 90° solar-zenith angle on the dawn side of the magnetosphere is considered in more detail. Dispersive ions are seen at the edge of the magnetopause and at the edges of subsequently observed plasma structures. Changes in ion velocity distribution in plasma structures observed after the first magnetopause crossing suggest that what resembles multiple magnetopause crossings may be plasma blobs penetrating the magnetosphere. Observed variations of plasma parameters near magnetopause structures suggest nonstationary reconnection as the most probable mechanism for observed structures.

  2. Collaborative Research. Damage and Burst Dynamics in Failure of Complex Geomaterials. A Statistical Physics Approach to Understanding the Complex Emergent Dynamics in Near Mean-Field Geological Materials

    Energy Technology Data Exchange (ETDEWEB)

    Rundle, John B. [Univ. of California, Davis, CA (United States); Klein, William [Boston Univ., MA (United States)

    2015-09-29

    We have carried out research to determine the dynamics of failure in complex geomaterials, specifically focusing on the role of defects, damage and asperities in the catastrophic failure processes (now popularly termed “Black Swan events”). We have examined fracture branching and flow processes using models for invasion percolation, focusing particularly on the dynamics of bursts in the branching process. We have achieved a fundamental understanding of the dynamics of nucleation in complex geomaterials, specifically in the presence of inhomogeneous structures.

  3. The dichotomy between disease phenotype databases and the implications for understanding complex diseases involving the major histocompatibility complex.

    Science.gov (United States)

    Clark, P M; Kunkel, M; Monos, D S

    2015-12-01

    Many genes related to innate and adaptive immunity reside within the major histocompatibility complex (MHC) and have been associated with a multitude of complex, immune-related disorders. Despite years of genetic study, this region has seen few causative determinants discovered for immune-mediated diseases. Reported associations have been curated in various databases including the Genetic Association Database, NCBI database of clinically relevant variants (ClinVar) and the Human Gene Mutation Database and together capture genetic associations and annotated pathogenic loci within the MHC and across the genome for a variety of complex, immune-mediated diseases. A review of these three distinct databases reveals disparate annotations between associated genes and pathogenic loci, alluding to the polygenic, multifactorial nature of immune-mediated diseases and the pleiotropic character of genes within the MHC. The technical limitations and inherent biases imposed by current approaches and technologies in studying the MHC create a strong case for the need to perform targeted deep sequencing of the MHC and other immunologically relevant loci in order to fully elucidate and study the causative elements of complex immune-mediated diseases. © 2015 The Authors. International Journal of Immunogenetics Published by John Wiley & Sons Ltd.

  4. A Phospholipid-Protein Complex from Krill with Antioxidative and Immunomodulating Properties Reduced Plasma Triacylglycerol and Hepatic Lipogenesis in Rats

    Directory of Open Access Journals (Sweden)

    Marie S. Ramsvik

    2015-07-01

    Full Text Available Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have health benefits. We investigated a phospholipid-protein complex (PPC from krill that is hypothesized to influence lipid metabolism, inflammation, and redox status. Male Wistar rats were fed a control diet (2% soy oil, 8% lard, 20% casein, or diets where corresponding amounts of casein and lard were replaced with PPC at 3%, 6%, or 11% (wt %, for four weeks. Dietary supplementation with PPC resulted in significantly lower levels of plasma triacylglycerols in the 11% PPC-fed group, probably due to reduced hepatic lipogenesis. Plasma cholesterol levels were also reduced at the highest dose of PPC. In addition, the plasma and liver content of n-3 PUFAs increased while n-6 PUFAs decreased. This was associated with increased total antioxidant capacity in plasma and increased liver gene expression of mitochondrial superoxide dismutase (Sod2. Finally, a reduced plasma level of the inflammatory mediator interleukin-2 (IL-2 was detected in the PPC-fed animals. The present data show that PPC has lipid-lowering effects in rats, and may modulate risk factors related to cardiovascular disease progression.

  5. Complex carbohydrate diets are not capable of maintaining normal plasma calcium and phosphorus levels in vitamin D-deficient rats.

    OpenAIRE

    Underwood, J L; Phelps, M E; DeLuca, H F

    1984-01-01

    Substitution of Cerelose (glucose monohydrate) for complex carbohydrate (whole wheat flour) does not alter plasma calcium levels in vitamin D-deficient rats, contrary to a previous report. It is suspected that whole wheat flour may contain traces of vitamin D that result in a slower rate of depletion than found with Cerelose diets. Vitamin D-deficient rats showing low plasma 1,25-dihydroxyvitamin D3 levels and no detectable 25-hydroxyvitamin D3 levels in their blood show a hypocalcemia (5.6 m...

  6. A multi-diagnostic approach to understanding high-latitude plasma transport during the Halloween 2003 storm

    Directory of Open Access Journals (Sweden)

    P. Yin

    2008-09-01

    Full Text Available During the Halloween 2003 storm event, significant electron density enhancements at elevated F-layer altitudes were recorded by the EISCAT and ESR radars in northern Europe between 20:00 and 24:00 UT on 30 October. At the same time, a sequence of optical images from Qaanaaq in northern Greenland captured a series of eastward-propagating polar cap patches. In this paper, an advanced 4-D tomographic method based on the assimilation of global GPS data, coupled to a predictive Kalman filtering technique, has been used to reveal the linkage between these ionospheric structures. The combination of the various data sources has clearly established the time history of this extreme event, in which high-density plasma was uplifted in the dayside ionosphere and convected anti-sunward across the polar cap to European high latitudes at an elevated F-layer. Using this multi instrument approach, we can differentiate between those density structures observed at the ESR which occurred as a result of cross-polar transport and those more likely to have been produced by in-situ soft particle precipitation, a distinction which is supported by the ESR and EISCAT data. The multi-diagnostic approach reported here has the potential significantly to extend our current understanding of high latitude plasma transport and the origin of electron density enhancements.

  7. The Value of a Comparative Approach to Understand the Complex Interplay between Microbiota and Host Immunity.

    Science.gov (United States)

    Morella, Norma M; Koskella, Britt

    2017-01-01

    The eukaryote immune system evolved and continues to evolve within a microbial world, and as such is critically shaped by-and in some cases even reliant upon-the presence of host-associated microbial species. There are clear examples of adaptations that allow the host to simultaneously tolerate and/or promote growth of symbiotic microbiota while protecting itself against pathogens, but the relationship between immunity and the microbiome reaches far beyond simple recognition and includes complex cross talk between host and microbe as well as direct microbiome-mediated protection against pathogens. Here, we present a broad but brief overview of how the microbiome is controlled by and interacts with diverse immune systems, with the goal of identifying questions that can be better addressed by taking a comparative approach across plants and animals and different types of immunity. As two key examples of such an approach, we focus on data examining the importance of early exposure on microbiome tolerance and immune system development and function, and the importance of transmission among hosts in shaping the potential coevolution between, and long-term stability of, host-microbiome associations. Then, by comparing existing evidence across short-lived plants, mouse model systems and humans, and insects, we highlight areas of microbiome research that are strong in some systems and absent in others with the hope of guiding future research that will allow for broad-scale comparisons moving forward. We argue that such an approach will not only help with identification of generalities in host-microbiome-immune interactions but also improve our understanding of the role of the microbiome in host health.

  8. Raman analysis of DLC coated engine components with complex shape: Understanding wear mechanisms

    International Nuclear Information System (INIS)

    Jaoul, C.; Jarry, O.; Tristant, P.; Merle-Mejean, T.; Colas, M.; Dublanche-Tixier, C.; Jacquet, J.-M.

    2009-01-01

    Hydrogenated amorphous carbon (a-C:H) films were deposited on flat samples and engine components using an industrial scale reactor. Characterization of the coating allowed validating its application on engine parts due to high hardness (32 GPa) and high level of adhesion achieved using sublayers. The original approach of this work concerned the use of Raman analysis not only on flat samples after tribometer tests but also directly on coated engine parts with complex shape (like cam/follower system), in order to understand wear mechanisms occurring in motorsport engines. As wear could lead to a coating thickness decrease, a particular attention was paid on the Raman signal of the sublayers. Among the different values extracted from Raman spectrum to characterize structural organization, the value of G peak intensity appeared as a criterion of validity of analyses because it is directly linked to the remaining thickness of the a-C:H layer. For flat samples tested on ball-on-disc tribometer, structure of a-C:H film observed by Raman spectroscopy in the wear track remained stable in depth. Then, a-C:H coated engine components were studied before and after working in real conditions. Two different wear mechanisms were identified. The first one did not show any structural modification of the bulk a-C:H layer. In the second one, the high initial roughness of samples (R t = 1.15 μm) lead to coating delaminations after sliding. Massive graphitization which decreases drastically mechanical properties of the coatings was observed by Raman analyses on the contact area. The increase of the temperature on rough edges of the scratches could explain this graphitization.

  9. The Value of a Comparative Approach to Understand the Complex Interplay between Microbiota and Host Immunity

    Directory of Open Access Journals (Sweden)

    Norma M. Morella

    2017-09-01

    Full Text Available The eukaryote immune system evolved and continues to evolve within a microbial world, and as such is critically shaped by—and in some cases even reliant upon—the presence of host-associated microbial species. There are clear examples of adaptations that allow the host to simultaneously tolerate and/or promote growth of symbiotic microbiota while protecting itself against pathogens, but the relationship between immunity and the microbiome reaches far beyond simple recognition and includes complex cross talk between host and microbe as well as direct microbiome-mediated protection against pathogens. Here, we present a broad but brief overview of how the microbiome is controlled by and interacts with diverse immune systems, with the goal of identifying questions that can be better addressed by taking a comparative approach across plants and animals and different types of immunity. As two key examples of such an approach, we focus on data examining the importance of early exposure on microbiome tolerance and immune system development and function, and the importance of transmission among hosts in shaping the potential coevolution between, and long-term stability of, host–microbiome associations. Then, by comparing existing evidence across short-lived plants, mouse model systems and humans, and insects, we highlight areas of microbiome research that are strong in some systems and absent in others with the hope of guiding future research that will allow for broad-scale comparisons moving forward. We argue that such an approach will not only help with identification of generalities in host–microbiome–immune interactions but also improve our understanding of the role of the microbiome in host health.

  10. Applying Within-Family Differences Approaches to Enhance Understanding of the Complexity of Intergenerational Relations.

    Science.gov (United States)

    Suitor, J Jill; Gilligan, Megan; Pillemer, Karl; Fingerman, Karen L; Kim, Kyungmin; Silverstein, Merril; Bengtson, Vern L

    2017-12-15

    The role of family relationships in the lives of older adults has received substantial attention in recent decades. Scholars have increasingly looked beyond simple models of family relations to approaches that recognize the complex and sometimes contradictory nature of these ties. One of the most exciting conceptual and methodological developments is the application of within-family differences approaches. In this paper, we focus on the ways in which such within-family approaches can extend the understanding of patterns and consequences of intergenerational ties in adulthood. Following a review of the conceptual underpinnings of within-family differences approaches, we provide empirical illustrations of these approaches from three projects conducted in the United States: the Family Exchanges Study (FES), the Longitudinal Study of Generations (LSOG), and the Within-Family Differences Study (WFDS). Analyses from the FES, LSOG, and WFDS reveal differences in the consequences of patterns of intergenerational relations found when using within-family compared to between-family approaches. In particular, these analyses demonstrate considerable variation within families that shapes patterns and consequences of parent-adult child ties that is masked when such variations are not taken into account. Within-family differences approaches have been shown to shed new light on intergenerational relations. Despite the value of within-family designs, their use may be limited by the higher investment of finances and time required to implement such studies. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  11. Bringing content understanding into usability testing in complex application domains—a case study in eHealth

    DEFF Research Database (Denmark)

    Andersen, Simon Bruntse; Rasmussen, Claire Kirchert; Frøkjær, Erik

    2017-01-01

    A usability evaluation technique, Cooperative Usability Testing with Questions of Understanding (CUT with QU) intended to illuminate users’ ability to understand the content information of an application is proposed. In complex application domains as for instance the eHealth domain, this issue...... the participation of four physiotherapists and four clients in a period of 3.5 months, it was demonstrated how CUT with QU can complement conventional usability testing and provide insight into users’ challenges with understanding of a new complex eHealth application. More experiments in other complex application...... domains involving different kinds of users and evaluators are needed before we can tell whether CUT with QU is an effective usability testing technique of wider applicability. Performing CUT with QU is very demanding by drawing heavily on the evaluators’ ability to respond effectively to openings...

  12. Significant elevation and correlation of plasma neutrophil gelatinase associated lipocalin and its complex with matrix metalloproteinase-9 in patients with pelvic inflammatory disease.

    Science.gov (United States)

    Tsai, Hsiu-Ting; Su, Pen-Hua; Lee, Tsung-Hsien; Tee, Yi-Torng; Lin, Long-Yau; Yang, Shun-Fa; Wang, Po-Hui

    2011-06-11

    To detect the expression of plasma neutrophil gelatinase associated lipocalin (NGAL) and its complex with matrix metalloproteinase-9 (MMP-9) in patients with pelvic inflammatory disease (PID). Enzyme-linked immunosorbent assay was used to measure the levels of plasma NGAL and NGAL/MMP-9 complex. The levels of plasma NGAL or NGAL/MMP-9 complex were increased in patients with PID compared with those in normal controls and decreased significantly after treatment. Pre-treatment plasma level of NGAL was significantly correlated with WBC and neutrophil counts. In patients with PID, plasma level of NGAL/MMP-9 complex was correlated with plasma level of NGAL or MMP-9 significantly. In predicting PID, the sensitivities of NGAL and NGAL/MMP-9 complex were 76.6% and 78.1%; the negative predictive values, 72.7% and 74.5%. Plasma NGAL and NGAL/MMP-9 complex may act as diagnostic adjuvant biomarkers for PID. In patients with PID, about 80% have plasma levels of NGAL or NGAL/MMP-9 complex level >10.04 ng/ml or 2.33 ng/ml, respectively. Copyright © 2011. Published by Elsevier B.V.

  13. A lignan complex isolated from flaxseed does not affect plasma lipid concentrations or antioxidant capacity in healthy postmenopausal women

    DEFF Research Database (Denmark)

    Hallund, Jesper; Ravn-Haren, Gitte; Bügel, S.

    2006-01-01

    antioxidant capacity, The aim of this study was to investigate the effects of a lignan complex, providing 500 mg/d of SDG, on serum concentration and urinary excretion of ENL, plasma lipids, serum lipoprotein oxidation resistance, and markers of antioxidant capacity. Healthy postmenopausal women (n=22...... (LDL-C), HDL cholesterol (HDL-C), triacylglycerol (TAG), serum lipoprotein oxidation lag time, plasma Trolox-equivalent antioxidant capacity (TEAC), and ferric reducing ability of plasma (FRAP) were measured at the beginning and end of each intervention period. ENL concentrations in serum (P ....001) and ENL urinary excretion (P lipoprotein oxidation lag time, TEAC and FRAP were not affected. Daily consumption for 6 wk of a low-fat muffin enriched...

  14. Computing the complex : Dusty plasmas in the presence of magnetic fields and UV radiation

    NARCIS (Netherlands)

    Land, V.

    2007-01-01

    About 90% of the visible universe is plasma. Interstellar clouds, stellar cores and atmospheres, the Solar wind, the Earth's ionosphere, polar lights, and lightning are all plasma; ionized gases, consisting of electrons, ions, and neutrals. Not only many industries, like the microchip and solar cell

  15. Fluorogenic MMP activity assay for plasma including MMPs complexed to α2-macroglobulin

    NARCIS (Netherlands)

    Beekman, B.; Drijfhout, J.W.; Ronday, H.K.; TeKoppele, J.M.

    1999-01-01

    Elevated MMP activities are implicated in tissue degradation in, e.g., arthritis and cancer. The present study was designed to measure MMP enzyme activity in plasma. Free active MMP is unlikely to be present in plasma: upon entering the circulation, active MMP is expected to be captured by the

  16. Application of stereoscopic particle image velocimetry to studies of transport in a dusty (complex) plasma

    International Nuclear Information System (INIS)

    Thomas, Edward Jr.; Williams, Jeremiah D.; Silver, Jennifer

    2004-01-01

    Over the past 5 years, two-dimensional particle image velocimetry (PIV) techniques [E. Thomas, Jr., Phys. Plasmas 6, 2672 (1999)] have been used to obtain detailed measurements of microparticle transport in dusty plasmas. This Letter reports on an extension of these techniques to a three-dimensional velocity vector measurement approach using stereoscopic PIV. Initial measurements using the stereoscopic PIV diagnostic are presented

  17. On Influence of Neutrals on Dust Particle Charging in Complex Plasmas in the Presence of Electromagnetic Radiation

    Science.gov (United States)

    Kopnin, S. I.; Morzhakova, A. A.; Popel, S. I.; Shukla, P. K.

    2011-11-01

    Effects associated with neutral component of complex (dusty) ionospheric plasmas which affect dust particle charging are studied. Microscopic ion currents on dust particles with taking into account ion-neutral interaction are presented. Calculations are performed both for the case of negative charges of dust particles, when the influence of Solar radiation on dust particle charging processes is negligible, and for the case of positive charges which is realized in the presence of sufficiently intensive UV or X-ray radiation. We also carry out investigation of the electron heating due to the photoelectric effect. We show that the efficiency of electron heating depends on the density of neutral component of the plasma. As result, we determine altitudes where the influence of the neutral plasma component on dust particle charging processes as well as the electron heating effect are significant and should be taken into account under consideration of the ionospheric complex plasmas. In particular, we show that the effects considered could be important for the description of noctilucent clouds, polar mesosphere summer echoes, and some other physical phenomena associated with dust particles in the ionosphere.

  18. Klotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depression.

    Science.gov (United States)

    Pavlatou, M G; Remaley, A T; Gold, P W

    2016-08-30

    Klotho is a hormone secreted into human cerebrospinal fluid (CSF), plasma and urine that promotes longevity and influences the onset of several premature senescent phenotypes in mice and humans, including atherosclerosis, cardiovascular disease, stroke and osteoporosis. Preliminary studies also suggest that Klotho possesses tumor suppressor properties. Klotho's roles in these phenomena were first suggested by studies demonstrating that a defect in the Klotho gene in mice results in a significant decrease in lifespan. The Klotho-deficient mouse dies prematurely at 8-9 weeks of age. At 4-5 weeks of age, a syndrome resembling human ageing emerges consisting of atherosclerosis, osteoporosis, cognitive disturbances and alterations of hippocampal architecture. Several deficits in Klotho-deficient mice are likely to contribute to these phenomena. These include an inability to defend against oxidative stress in the central nervous system and periphery, decreased capacity to generate nitric oxide to sustain normal endothelial reactivity, defective Klotho-related mediation of glycosylation and ion channel regulation, increased insulin/insulin-like growth factor signaling and a disturbed calcium and phosphate homeostasis accompanied by altered vitamin D levels and ectopic calcification. Identifying the mechanisms by which Klotho influences multiple important pathways is an emerging field in human biology that will contribute significantly to understanding basic physiologic processes and targets for the treatment of complex diseases. Because many of the phenomena seen in Klotho-deficient mice occur in depressive illness, major depression and bipolar disorder represent illnesses potentially associated with Klotho dysregulation. Klotho's presence in CSF, blood and urine should facilitate its study in clinical populations.

  19. Understanding Adult Learning in the Midst of Complex Social "Liquid Modernity"

    Science.gov (United States)

    Nicolaides, Aliki; Marsick, Victoria J.

    2016-01-01

    This chapter describes the changing nature of adult education theory and practice in the face of complex, disruptive change and explores theories that are suited to tectonic shifts in a period of what we describe as "liquid modernity" in the midst of complex sociocultural-economic-political change in a global environment.

  20. Understanding IS Complexity and the Heterogeneity of Frames: The Illusion of Agreement

    NARCIS (Netherlands)

    Jochemsen, E.J.; Rezazade Mehrizi, M.H.; van den Hooff, B.J.; Plomp, M.G.A.

    2016-01-01

    Organizations are confronted with increasing levels of IS complexity. The socio-technical nature of IS implies that IS complexity stems from not only the structure of technology (e.g., how many elements and relations), but also from the subjective perceptions organizational actors have regarding

  1. Understanding complex governance relationships in food safety regulation : The RIT model as a theoretical lens

    NARCIS (Netherlands)

    Havinga, Tetty; Verbruggen, Paul

    In this contribution we discuss the added value of the RIT model for the analysis of complex governance relationships in the regulation of food safety. By exploring regimes of food safety involving the European Union and the Global Food Safety Initiative, we highlight the diverse and complex

  2. Understanding the Complexity of Temperature Dynamics in Xinjiang, China, from Multitemporal Scale and Spatial Perspectives

    Directory of Open Access Journals (Sweden)

    Jianhua Xu

    2013-01-01

    Full Text Available Based on the observed data from 51 meteorological stations during the period from 1958 to 2012 in Xinjiang, China, we investigated the complexity of temperature dynamics from the temporal and spatial perspectives by using a comprehensive approach including the correlation dimension (CD, classical statistics, and geostatistics. The main conclusions are as follows (1 The integer CD values indicate that the temperature dynamics are a complex and chaotic system, which is sensitive to the initial conditions. (2 The complexity of temperature dynamics decreases along with the increase of temporal scale. To describe the temperature dynamics, at least 3 independent variables are needed at daily scale, whereas at least 2 independent variables are needed at monthly, seasonal, and annual scales. (3 The spatial patterns of CD values at different temporal scales indicate that the complex temperature dynamics are derived from the complex landform.

  3. Understanding complex clinical reasoning in infectious diseases for improving clinical decision support design.

    Science.gov (United States)

    Islam, Roosan; Weir, Charlene R; Jones, Makoto; Del Fiol, Guilherme; Samore, Matthew H

    2015-11-30

    Clinical experts' cognitive mechanisms for managing complexity have implications for the design of future innovative healthcare systems. The purpose of the study is to examine the constituents of decision complexity and explore the cognitive strategies clinicians use to control and adapt to their information environment. We used Cognitive Task Analysis (CTA) methods to interview 10 Infectious Disease (ID) experts at the University of Utah and Salt Lake City Veterans Administration Medical Center. Participants were asked to recall a complex, critical and vivid antibiotic-prescribing incident using the Critical Decision Method (CDM), a type of Cognitive Task Analysis (CTA). Using the four iterations of the Critical Decision Method, questions were posed to fully explore the incident, focusing in depth on the clinical components underlying the complexity. Probes were included to assess cognitive and decision strategies used by participants. The following three themes emerged as the constituents of decision complexity experienced by the Infectious Diseases experts: 1) the overall clinical picture does not match the pattern, 2) a lack of comprehension of the situation and 3) dealing with social and emotional pressures such as fear and anxiety. All these factors contribute to decision complexity. These factors almost always occurred together, creating unexpected events and uncertainty in clinical reasoning. Five themes emerged in the analyses of how experts deal with the complexity. Expert clinicians frequently used 1) watchful waiting instead of over- prescribing antibiotics, engaged in 2) theory of mind to project and simulate other practitioners' perspectives, reduced very complex cases into simple 3) heuristics, employed 4) anticipatory thinking to plan and re-plan events and consulted with peers to share knowledge, solicit opinions and 5) seek help on patient cases. The cognitive strategies to deal with decision complexity found in this study have important

  4. The Understanding of "Concept Study" in Teachers' Professional Learning: A Lived Experience of Complexity Inquiry

    Science.gov (United States)

    Wang, Xiong

    2015-01-01

    This paper used narrative to present the author's understanding process of "concept study" in teachers' professional learning. The understanding process was advanced by several questions emerging from the preparation of doing "concept study". Thus, the several questions and their solutions became the threads of the narrative.…

  5. Complex contexts and dynamic drivers: Understanding four decades of forest loss and recovery in an East African protected area

    NARCIS (Netherlands)

    Sassen, M.; Sheil, D.; Giller, K.E.; Braak, ter C.J.F.

    2013-01-01

    Protected forests are sometimes encroached by surrounding communities. But patterns of cover change can vary even within one given setting – understanding these complexities can offer insights into the effective maintenance of forest cover. Using satellite image analyses together with historical

  6. On understanding creative language : The late positive complex and novel metaphor comprehension

    NARCIS (Netherlands)

    Rataj, Karolina; Przekoracka-Krawczyk, Anna; van der Lubbe, Rob H.J.

    2018-01-01

    Novel metaphoric sentences have repeatedly evoked larger N400 amplitudes than literal sentences, while investigations of the late positive complex (LPC) have brought inconsistent results, with reports of both increased and reduced amplitudes. In two experiments, we examined novel metaphor

  7. Understanding the Fatigue Behavior of FML Structures and Materials under Complex Variable Amplitude Loading

    NARCIS (Netherlands)

    Alderdiesten, R.; Benedictus, R.; Khan, S.

    2009-01-01

    This paper presents various failure mechanisms in FMLs, highlights the presence or absence of interaction effects, and describes how the failure mechanisms can be described for predicting damage growth under arbitrary complex load spectra.

  8. Understanding and Mitigating the Charging Behavior of Next Generation Complex and Active Spacecraft

    Data.gov (United States)

    National Aeronautics and Space Administration — Spacecraft that are fundamentally more complex and higher powered are necessary to expand our scientific missions and take commercial space endeavors to the next...

  9. Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease.

    Science.gov (United States)

    Borroto-Escuela, Dasiel O; Carlsson, Jens; Ambrogini, Patricia; Narváez, Manuel; Wydra, Karolina; Tarakanov, Alexander O; Li, Xiang; Millón, Carmelo; Ferraro, Luca; Cuppini, Riccardo; Tanganelli, Sergio; Liu, Fang; Filip, Malgorzata; Diaz-Cabiale, Zaida; Fuxe, Kjell

    2017-01-01

    The introduction of allosteric receptor-receptor interactions in G protein-coupled receptor (GPCR) heteroreceptor complexes of the central nervous system (CNS) gave a new dimension to brain integration and neuropsychopharmacology. The molecular basis of learning and memory was proposed to be based on the reorganization of the homo- and heteroreceptor complexes in the postjunctional membrane of synapses. Long-term memory may be created by the transformation of parts of the heteroreceptor complexes into unique transcription factors which can lead to the formation of specific adapter proteins. The observation of the GPCR heterodimer network (GPCR-HetNet) indicated that the allosteric receptor-receptor interactions dramatically increase GPCR diversity and biased recognition and signaling leading to enhanced specificity in signaling. Dysfunction of the GPCR heteroreceptor complexes can lead to brain disease. The findings of serotonin (5-HT) hetero and isoreceptor complexes in the brain over the last decade give new targets for drug development in major depression. Neuromodulation of neuronal networks in depression via 5-HT, galanin peptides and zinc involve a number of GPCR heteroreceptor complexes in the raphe-hippocampal system: GalR1-5-HT1A, GalR1-5-HT1A-GPR39, GalR1-GalR2, and putative GalR1-GalR2-5-HT1A heteroreceptor complexes. The 5-HT1A receptor protomer remains a receptor enhancing antidepressant actions through its participation in hetero- and homoreceptor complexes listed above in balance with each other. In depression, neuromodulation of neuronal networks in the raphe-hippocampal system and the cortical regions via 5-HT and fibroblast growth factor 2 involves either FGFR1-5-HT1A heteroreceptor complexes or the 5-HT isoreceptor complexes such as 5-HT1A-5-HT7 and 5-HT1A-5-HT2A. Neuromodulation of neuronal networks in cocaine use disorder via dopamine (DA) and adenosine signals involve A2AR-D2R and A2AR-D2R-Sigma1R heteroreceptor complexes in the dorsal and

  10. Understanding M-ligand bonding and mer-/fac-isomerism in tris(8-hydroxyquinolinate) metallic complexes.

    Science.gov (United States)

    Lima, Carlos F R A C; Taveira, Ricardo J S; Costa, José C S; Fernandes, Ana M; Melo, André; Silva, Artur M S; Santos, Luís M N B F

    2016-06-28

    Tris(8-hydroxyquinolinate) metallic complexes, Mq3, are one of the most important classes of organic semiconductor materials. Herein, the nature of the chemical bond in Mq3 complexes and its implications on their molecular properties were investigated by a combined experimental and computational approach. Various Mq3 complexes, resulting from the alteration of the metal and substitution of the 8-hydroxyquinoline ligand in different positions, were prepared. The mer-/fac-isomerism in Mq3 was explored by FTIR and NMR spectroscopy, evidencing that, irrespective of the substituent, mer- and fac-are the most stable molecular configurations of Al(iii) and In(iii) complexes, respectively. The relative M-ligand bond dissociation energies were evaluated experimentally by electrospray ionization tandem mass spectrometry (ESI-MS-MS), showing a non-monotonous variation along the group (Al > In > Ga). The results reveal a strong covalent character in M-ligand bonding, which allows for through-ligand electron delocalization, and explain the preferred molecular structures of Mq3 complexes as resulting from the interplay between bonding and steric factors. The mer-isomer reduces intraligand repulsions, being preferred for smaller metals, while the fac-isomer is favoured for larger metals where stronger covalent M-ligand bonds can be formed due to more extensive through-ligand conjugation mediated by metal "d" orbitals.

  11. Improving the understanding and treatment of complex grief: an important issue for psychotraumatology

    Directory of Open Access Journals (Sweden)

    Paul A. Boelen

    2016-09-01

    Full Text Available In the Netherlands, every year 500,000 people are confronted with the death of a close relative. Many of these people experience little emotional distress. In some, bereavement precipitates severe grief, distress, and dysphoria. A small yet significant minority of bereaved individuals develops persistent and debilitating symptoms of persistent complex bereavement disorder (PCBD (also termed prolonged grief disorder, posttraumatic stress disorder, and depression. Knowledge about early identification of, and preventive care for complex grief has increased. Moreover, in recent years there has been an increase in treatment options for people for whom loss leads to persistent psychological problems. That said, preventive and curative treatments are effective for some, but not all bereaved individuals experiencing distress and dysfunction following loss. This necessitates further research on the development, course, and treatment of various stages of complex grief, including PCBD. Highlights of the article:

  12. Quasilongitudinal soliton in a two-dimensional strongly coupled complex dusty plasma in the presence of an external magnetic field.

    Science.gov (United States)

    Ghosh, Samiran

    2014-09-01

    The propagation of a nonlinear low-frequency mode in two-dimensional (2D) monolayer hexagonal dusty plasma crystal in presence of external magnetic field and dust-neutral collision is investigated. The standard perturbative approach leads to a 2D Korteweg-de Vries (KdV) soliton for the well-known dust-lattice mode. However, the Coriolis force due to crystal rotation and Lorentz force due to magnetic field on dust particles introduce a linear forcing term, whereas dust-neutral drag introduce the usual damping term in the 2D KdV equation. This new nonlinear equation is solved both analytically and numerically to show the competition between the linear forcing and damping in the formation of quasilongitudinal soliton in a 2D strongly coupled complex (dusty) plasma. Numerical simulation on the basis of the typical experimental plasma parameters and the analytical solution reveal that the neutral drag force is responsible for the usual exponential decay of the soliton, whereas Coriolis and/or Lorentz force is responsible for the algebraic decay as well as the oscillating tail formation of the soliton. The results are discussed in the context of the plasma crystal experiment.

  13. Enhancing Understanding of Magnetized High Energy Density Plasmas from Solid Liner Implosions Using Fluid Modeling with Kinetic Closures

    Science.gov (United States)

    Masti, Robert; Srinivasan, Bhuvana; King, Jacob; Stoltz, Peter; Hansen, David; Held, Eric

    2017-10-01

    Recent results from experiments and simulations of magnetically driven pulsed power liners have explored the role of early-time electrothermal instability in the evolution of the MRT (magneto-Rayleigh-Taylor) instability. Understanding the development of these instabilities can lead to potential stabilization mechanisms; thereby providing a significant role in the success of fusion concepts such as MagLIF (Magnetized Liner Inertial Fusion). For MagLIF the MRT instability is the most detrimental instability toward achieving fusion energy production. Experiments of high-energy density plasmas from wire-array implosions have shown the requirement for more advanced physics modeling than that of ideal magnetohydrodynamics. The overall focus of this project is on using a multi-fluid extended-MHD model with kinetic closures for thermal conductivity, resistivity, and viscosity. The extended-MHD model has been updated to include the SESAME equation-of-state tables and numerical benchmarks with this implementation will be presented. Simulations of MRT growth and evolution for MagLIF-relevant parameters will be presented using this extended-MHD model with the SESAME equation-of-state tables. This work is supported by the Department of Energy Office of Science under Grant Number DE-SC0016515.

  14. CELLULOSE SYNTHASE INTERACTIVE1 Is Required for Fast Recycling of Cellulose Synthase Complexes to the Plasma Membrane in Arabidopsis

    Energy Technology Data Exchange (ETDEWEB)

    Lei, Lei; Singh, Abhishek; Bashline, Logan; Li, Shundai; Yingling, Yaroslava G.; Gu, Ying

    2015-10-06

    Plants are constantly subjected to various biotic and abiotic stresses and have evolved complex strategies to cope with these stresses. For example, plant cells endocytose plasma membrane material under stress and subsequently recycle it back when the stress conditions are relieved. Cellulose biosynthesis is a tightly regulated process that is performed by plasma membrane-localized cellulose synthase (CESA) complexes (CSCs). However, the regulatory mechanism of cellulose biosynthesis under abiotic stress has not been well explored. In this study, we show that small CESA compartments (SmaCCs) or microtubule-associated cellulose synthase compartments (MASCs) are critical for fast recovery of CSCs to the plasma membrane after stress is relieved in Arabidopsis thaliana. This SmaCC/MASC-mediated fast recovery of CSCs is dependent on CELLULOSE SYNTHASE INTERACTIVE1 (CSI1), a protein previously known to represent the link between CSCs and cortical microtubules. Independently, AP2M, a core component in clathrin-mediated endocytosis, plays a role in the formation of SmaCCs/MASCs. Together, our study establishes a model in which CSI1-dependent SmaCCs/MASCs are formed through a process that involves endocytosis, which represents an important mechanism for plants to quickly regulate cellulose synthesis under abiotic stress.

  15. Further Understanding of Complex Information Processing in Verbal Adolescents and Adults with Autism Spectrum Disorders

    Science.gov (United States)

    Williams, Diane L.; Minshew, Nancy J.; Goldstein, Gerald

    2015-01-01

    More than 20?years ago, Minshew and colleagues proposed the Complex Information Processing model of autism in which the impairment is characterized as a generalized deficit involving multiple modalities and cognitive domains that depend on distributed cortical systems responsible for higher order abilities. Subsequent behavioral work revealed a…

  16. Contemporary Leadership Theories. Enhancing the Understanding of the Complexity, Subjectivity and Dynamic of Leadership

    DEFF Research Database (Denmark)

    Winkler, Ingo

    . Leadership is understood as product of complex social relationships embedded in the logic and dynamic of the social system. The book discusses theoretical approaches from top leadership journals, but also addresses various alternatives that are suitable to challenge mainstream leadership research...

  17. Sedimentary Melanges and Fossil Mass-Transport Complexes: A Key for Better Understanding Submarine Mass Movements?

    NARCIS (Netherlands)

    Pini, Gian Andrea; Ogata, Kei; Camerlenghi, Angelo; Festa, Andrea; Lucente, Claudio Corrado; Codegone, Giulia

    2012-01-01

    Mélanges originated from sedimentary processes (sedimentary mélanges) and olistostromes are frequently present in mountain chains worldwide. They are excellent fossil examples of mass- Transport complexes (MTC), often cropping out in well-preserved and laterally continuous exposures. In this article

  18. Understanding the Complex Dimensions of the Digital Divide: Lessons Learned in the Alaskan Arctic

    Science.gov (United States)

    Subramony, Deepak Prem

    2007-01-01

    An ethnographic case study of Inupiat Eskimo in the Alaskan Arctic has provided insights into the complex nature of the sociological issues surrounding equitable access to technology tools and skills, which are referred to as the digital divide. These people can overcome the digital divide if they get the basic ready access to hardware and…

  19. Understanding the Complex Processes in Developing Student Teachers' Knowledge about Grammar

    Science.gov (United States)

    Svalberg, Agneta M.-L.

    2015-01-01

    This article takes the view that grammar is driven by user choices and is therefore complex and dynamic. This has implications for the teaching of grammar in language teacher education and how teachers' cognitions about grammar, and hence their own grammar teaching, might change. In this small, interpretative study, the participants--students on…

  20. Language complexity during read-alouds and kindergartners' vocabulary and symbolic understanding

    NARCIS (Netherlands)

    Mascareño Lara, Mayra; Snow, Catherine E.; Deunk, Marjolein I.; Bosker, Roel J.

    2016-01-01

    We explored links between complexity of teacher-child verbal interaction and child language and literacy outcomes in fifteen whole-class read-aloud sessions in Chilean kindergarten classrooms serving children from low socioeconomic backgrounds. We coded teacher and child turns for function

  1. Supporting Individuals with Autism Spectrum Disorder in Understanding and Coping with Complex Social Emotional Issues

    Science.gov (United States)

    Ahlers, Kaitlyn P.; Gabrielsen, Terisa P.; Lewis, Danielle; Brady, Anna M.; Litchford, April

    2017-01-01

    Core deficits in autism spectrum disorder (ASD) center around social communication and behavior. For those with ASD, these deficits complicate the task of learning how to cope with and manage complex social emotional issues. Although individuals with ASD may receive sufficient academic and basic behavioral support in school settings, supports for…

  2. Using multi-criteria analysis of simulation models to understand complex biological systems

    Science.gov (United States)

    Maureen C. Kennedy; E. David. Ford

    2011-01-01

    Scientists frequently use computer-simulation models to help solve complex biological problems. Typically, such models are highly integrated, they produce multiple outputs, and standard methods of model analysis are ill suited for evaluating them. We show how multi-criteria optimization with Pareto optimality allows for model outputs to be compared to multiple system...

  3. Techniques to better understand complex epikarst hydrogeology and contaminant transport in telogenetic karst settings

    Science.gov (United States)

    The movement of autogenic recharge through the shallow epikarstic zone in soil-mantled karst aquifers is important in understanding recharge areas and rates, groundwater storage, and contaminant transport processes. The groundwater flow in agricultural karst areas, such as Kentucky’s Pennyroyal Plat...

  4. Complex Problem Solving in Radiologic Technology: Understanding the Roles of Experience, Reflective Judgment, and Workplace Culture

    Science.gov (United States)

    Yates, Jennifer L.

    2011-01-01

    The purpose of this research study was to explore the process of learning and development of problem solving skills in radiologic technologists. The researcher sought to understand the nature of difficult problems encountered in clinical practice, to identify specific learning practices leading to the development of professional expertise, and to…

  5. Preschoolers' Implicit and Explicit False-Belief Understanding: Relations with Complex Syntactical Mastery

    Science.gov (United States)

    Low, Jason

    2010-01-01

    Three studies were carried out to investigate sentential complements being the critical device that allows for false-belief understanding in 3- and 4-year-olds (N = 102). Participants across studies accurately gazed in anticipation of a character's mistaken belief in a predictive looking task despite erring on verbal responses for direct…

  6. Landscape community genomics: understanding eco-evolutionary processes in complex environments

    Science.gov (United States)

    Hand, Brian K.; Lowe, Winsor H.; Kovach, Ryan P.; Muhlfeld, Clint C.; Luikart, Gordon

    2015-01-01

    Extrinsic factors influencing evolutionary processes are often categorically lumped into interactions that are environmentally (e.g., climate, landscape) or community-driven, with little consideration of the overlap or influence of one on the other. However, genomic variation is strongly influenced by complex and dynamic interactions between environmental and community effects. Failure to consider both effects on evolutionary dynamics simultaneously can lead to incomplete, spurious, or erroneous conclusions about the mechanisms driving genomic variation. We highlight the need for a landscape community genomics (LCG) framework to help to motivate and challenge scientists in diverse fields to consider a more holistic, interdisciplinary perspective on the genomic evolution of multi-species communities in complex environments.

  7. Eating disorder emergencies: understanding the medical complexities of the hospitalized eating disordered patient.

    Science.gov (United States)

    Cartwright, Martina M

    2004-12-01

    Eating disorders are maladaptive eating behaviors that typically develop in adolescence and early adulthood. Psychiatric maladies and comorbid conditions, especially insulin-dependent diabetes mellitus, frequently co-exist with eating disorders. Serious medical complications affecting all organs and tissues can develop and result in numerous emergent hospitalizations. This article reviews the pathophysiologies of anorexia nervosa, bulimia nervosa, and orthorexia nervosa and discusses the complexities associated with the treatment of medical complications seen in these patients.

  8. Using mLearning and MOOCs to Understand Chaos, Emergence, and Complexity in Education

    Science.gov (United States)

    deWaard, Inge; Abajian, Sean; Gallagher, Michael Sean; Hogue, Rebecca; Keskin, Nilgun; Koutropoulos, Apostolos; Rodriguez, Osvaldo C.

    2011-01-01

    In this paper, we look at how the massive open online course (MOOC) format developed by connectivist researchers and enthusiasts can help analyze the complexity, emergence, and chaos at work in the field of education today. We do this through the prism of a MobiMOOC, a six-week course focusing on mLearning that ran from April to May 2011. MobiMOOC…

  9. Systems-synthetic biology in understanding the complexities and simple devices in immunology.

    Science.gov (United States)

    Soni, Bhavnita; Nimsarkar, Prajakta; Mol, Milsee; Saha, Bhaskar; Singh, Shailza

    2018-03-23

    Systems and synthetic biology in the coming era has the ability to manipulate, stimulate and engineer cells to counteract the pathogenic immune response. The inherent biological complexities associated with the creation of a device allow capitalizing the biotechnological resources either by simply administering a recombinant cytokine or just reprogramming the immune cells. The strategy outlined, adopted and discussed may mark the beginning with promising therapeutics based on the principles of synthetic immunology. Copyright © 2018 Elsevier Ltd. All rights reserved.

  10. Complex Systems Biology Approach To Understanding Coordination of JAK-STAT Signaling

    OpenAIRE

    Soebiyanto, Radina P.; Sreenath, Sree N.; Qu, Cheng-Kui; Loparo, Kenneth A.; Bunting, Kevin D.

    2007-01-01

    In this work, we search for coordination as an organizing principle in a complex signaling system using a multilevel hierarchical paradigm. The objective is to explain the underlying mechanism of Interferon (IFNγ) induced JAK-STAT (specifically JAK1/JAK2-STAT1) pathway behavior. Starting with a mathematical model of the pathway from the literature, we modularize the system using biological knowledge via principles of biochemical cohesion, biological significance, and functionality. The modula...

  11. Douglas Hanahan: The daunting complexity of cancer: understanding the battlefield is a step towards winning the war

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    The Inaugural Grace-CERN Lecture The daunting complexity of cancer: understanding the battlefield is a step towards winning the war  Douglas Hanahan, Ph.D. Director, Swiss Institute for Experimental Cancer Research (ISREC)  Professor of Molecular Oncology, School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL) Vice Director, Swiss Cancer Center Lausanne Synopsis (version francaise ci-dessous) Cancer is a disease with hundreds of variations, both in affected organs and in responses to different therapies.  Modern human cancer research is producing an avalanche of data about the distinctive genetic aberrations of its specific types, further accentuating the diversity and vast complexity of the disease. There is hope that elucidating its mechanisms will lead to more informed and more effective therapeutic strategies.  Understanding the enemy is paramount, and yet tumors arising in different organs can be so different as to de...

  12. Complex plasma experimental device – A test bed for studying dust ...

    Indian Academy of Sciences (India)

    2016-11-03

    Nov 3, 2016 ... under microgravity experiments. This set-up is equip- ped with a specially designed Langmuir probe sys- tem, capable of working in a dusty plasma environment at high pressures, and a sophisticated high-resolution camera with high frame grabbing capability, in order to perform direct measurements of the ...

  13. Understanding ageing effects using complexity analysis of foot-ground clearance during walking.

    Science.gov (United States)

    Karmakar, Chandan; Khandoker, Ahsan; Begg, Rezaul; Palaniswami, Marimuthu

    2013-01-01

    Ageing influences gait patterns which in turn can affect the balance control of human locomotion. Entropy-based regularity and complexity measures have been highly effective in analysing a broad range of physiological signals. Minimum toe clearance (MTC) is an event during the swing phase of the gait cycle and is highly sensitive to the spatial balance control properties of the locomotor system. The aim of this research was to investigate the regularity and complexity of the MTC time series due to healthy ageing and locomotors' disorders. MTC data from 30 healthy young (HY), 27 healthy elderly (HE) and 10 falls risk (FR) elderly subjects with balance problems were analysed. Continuous MTC data were collected and using the first 500 data points, MTC mean, standard deviation (SD) and entropy-based complexity analysis were performed using sample entropy (SampEn) for different window lengths (m) and filtering levels (r). The MTC SampEn values were lower in the FR group compared to the HY and HE groups for all m and r. The HY group had a greater mean SampEn value than both HE and FR reflecting higher complexity in their MTC series. The mean SampEn values of HY and FR groups were found significantly different for m = 2, 4, 5 and r = (0.1-0.9) × SD, (0.3-0.9) × SD and (0.3-0.9) × SD, respectively. They were also significant difference between HE and FR groups for m = 4-5 and r = (0.3-0.7) × SD, but no significant differences were seen between HY and HE groups for any m and r. A significant correlation of SampEn with SD of MTC was revealed for the HY and HE groups only, suggesting that locomotor disorders could significantly change the regularity or the complexity of the MTC series while healthy ageing does not. These results can be usefully applied to the early diagnosis of common gait pathologies.

  14. Using a Design Science Perspective to Understand a Complex Design-Based Research Process

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    2012-01-01

    The purpose of the paper is to demonstrate how a design science perspective can be used to describe and understand a set of related design-based research processes. We describe and analyze a case study in a manner that is inspired by design science. The case study involves the design of modeling......-based research processes. And we argue that a design science perspective may be useful for both researchers and practitioners....... tools and the redesign of an information service in a library. We use a set of guidelines from a design science perspective to organize the description and analysis of the case study. By doing this we demonstrate the usefulness of design science as an analytical tool for understanding related design...

  15. A Diagrammatic Approach to Understanding Complex Eco-Social Interactions in Kathmandu, Nepal

    Directory of Open Access Journals (Sweden)

    R. Cynthia. Neudoerffer

    2005-12-01

    Full Text Available As part of developing an international network of community-based ecosystem approaches to health, a project was undertaken in a densely populated and socio-economically diverse area of Kathmandu, Nepal. Drawing on hundreds of pages of narrative reports based on surveys, interviews, secondary data, and focus groups by trained Nepalese facilitators, the authors created systemic depictions of relationships between multiple stakeholder groups, ecosystem health, and human health. These were then combined to examine interactions among stakeholders, activities, concerns, perceived needs, and resource states (ecosystem health indicators. These qualitative models have provided useful heuristics for both community members and research scholars to understand the eco-social systems in which they live; many of the strategies developed by the communities and researchers to improve health intuitively drew on this systemic understanding. The diagrams enabled researchers and community participants to explicitly examine relationships and conflicts related to health and environmental issues in their community.

  16. Enacting understanding of inclusion in complex contexts: Classroom practices of South African teachers

    Directory of Open Access Journals (Sweden)

    Petra Engelbrecht

    2015-08-01

    Full Text Available While the practice of inclusive education has recently been widely embraced as an ideal model for education, the acceptance of inclusive education practices has not translated into reality in most mainstream classrooms. Despite the fact that education policies in South Africa stipulate that all learners should be provided with the opportunities to participate as far as possible in all classroom activities, the implementation of inclusive education is still hampered by a combination of a lack of resources and the attitudes and actions of the teachers in the classroom. The main purpose of this paper was to develop a deeper understanding of a group of South African teachers' personal understanding about barriers to learning and how their understanding relates to their consequent actions to implement inclusive education in their classrooms. A qualitative research approach placed within a cultural-historical and bio-ecological theoretical framework was used. The findings, in this paper, indicate that the way in which teachers understand a diversity of learning needs is based on the training that they initially received as teachers, which focused on a deficit, individualised approach to barriers to learning and development, as well as contextual challenges, and that both have direct and substantial effects on teachers' classroom practices. As a result, they engage in practices in their classrooms that are less inclusive, by creating dual learning opportunities that are not sufficiently made available for everyone, with the result that every learner is not able to participate fully as an accepted member of their peer group in all classroom activities.

  17. Emergent nested systems a theory of understanding and influencing complex systems as well as case studies in urban systems

    CERN Document Server

    Walloth, Christian

    2016-01-01

    This book presents a theory as well as methods to understand and to purposively influence complex systems. It suggests a theory of complex systems as nested systems, i. e. systems that enclose other systems and that are simultaneously enclosed by even other systems. According to the theory presented, each enclosing system emerges through time from the generative activities of the systems they enclose. Systems are nested and often emerge unplanned, and every system of high dynamics is enclosed by a system of slower dynamics. An understanding of systems with faster dynamics, which are always guided by systems of slower dynamics, opens up not only new ways to understanding systems, but also to effectively influence them. The aim and subject of this book is to lay out these thoughts and explain their relevance to the purposive development of complex systems, which are exemplified in case studies from an urban system. The interested reader, who is not required to be familiar with system-theoretical concepts or wit...

  18. Understanding the Narratives Explaining the Ukrainian Crisis: Identity Divisions and Complex Diversity in Ukraine

    Directory of Open Access Journals (Sweden)

    Smoor Lodewijk

    2017-09-01

    Full Text Available The central argument of this paper is that radical and opposing interpretations of the Ukrainian conflict in politics and media should be studied as offspring of broader narratives. These narratives can be better understood by examining the national identity of Ukraine. Since Ukrainian national identity shows a high degree of diversity, it offers a rich source of arguments for any party wanting to give an interpretation of the present Ukrainian crisis. Narratives explaining the crisis often ignore this complex diversity or deliberately use elements from it to construct the ‘desired’ narrative.

  19. Take a stand on understanding: electrophysiological evidence for stem access in German complex verbs.

    Science.gov (United States)

    Smolka, Eva; Gondan, Matthias; Rösler, Frank

    2015-01-01

    The lexical representation of complex words in Indo-European languages is generally assumed to depend on semantic compositionality. This study investigated whether semantically compositional and noncompositional derivations are accessed via their constituent units or as whole words. In an overt visual priming experiment (300 ms stimulus onset asynchrony, SOA), event-related potentials (ERPs) were recorded for verbs (e.g., ziehen, "pull") that were preceded by purely semantically related verbs (e.g., zerren, "drag"), by morphologically related and semantically compositional verbs (e.g., zuziehen, "pull together"), by morphologically related and semantically noncompositional verbs (e.g., erziehen, "educate"), by orthographically similar verbs (e.g., zielen, "aim"), or by unrelated verbs (e.g., tarnen, "mask"). Compared to the unrelated condition, which evoked an N400 effect with the largest amplitude at centro-parietal recording sites, the N400 was reduced in all other conditions. The rank order of N400 amplitudes turned out as follows: morphologically related and semantically compositional ≈ morphologically related and semantically noncompositional morphologically related primes produced similar N400 modulations-irrespective of their semantic compositionality. The control conditions with orthographic similarity confirmed that these morphological effects were not the result of a simple form overlap between primes and targets. Our findings suggest that the lexical representation of German complex verbs refers to their base form, regardless of meaning compositionality. Theories of the lexical representation of German words need to incorporate this aspect of language processing in German.

  20. Understanding characteristics in multivariate traffic flow time series from complex network structure

    Science.gov (United States)

    Yan, Ying; Zhang, Shen; Tang, Jinjun; Wang, Xiaofei

    2017-07-01

    Discovering dynamic characteristics in traffic flow is the significant step to design effective traffic managing and controlling strategy for relieving traffic congestion in urban cities. A new method based on complex network theory is proposed to study multivariate traffic flow time series. The data were collected from loop detectors on freeway during a year. In order to construct complex network from original traffic flow, a weighted Froenius norm is adopt to estimate similarity between multivariate time series, and Principal Component Analysis is implemented to determine the weights. We discuss how to select optimal critical threshold for networks at different hour in term of cumulative probability distribution of degree. Furthermore, two statistical properties of networks: normalized network structure entropy and cumulative probability of degree, are utilized to explore hourly variation in traffic flow. The results demonstrate these two statistical quantities express similar pattern to traffic flow parameters with morning and evening peak hours. Accordingly, we detect three traffic states: trough, peak and transitional hours, according to the correlation between two aforementioned properties. The classifying results of states can actually represent hourly fluctuation in traffic flow by analyzing annual average hourly values of traffic volume, occupancy and speed in corresponding hours.

  1. #consumingitall: Understanding The Complex Relationship Between Media Consumption And Eating Behaviors

    OpenAIRE

    Albert, Stephanie L.

    2017-01-01

    Adolescents spend almost nine hours a day engaging with media. As a result, they are confronted with large amounts of obesogenic content that shapes their understanding of what are normal and acceptable eating behaviors. Utilizing primary data collected from a sample of 4,838 low-income, racially and ethnically diverse middle school students in Los Angeles County, I studied the effects of different types of media use (i.e., social media, TV/movies/videos, gaming, music, Internet) on dietary p...

  2. Application for 3d Scene Understanding in Detecting Discharge of Domesticwaste Along Complex Urban Rivers

    Science.gov (United States)

    Ninsalam, Y.; Qin, R.; Rekittke, J.

    2016-06-01

    In our study we use 3D scene understanding to detect the discharge of domestic solid waste along an urban river. Solid waste found along the Ciliwung River in the neighbourhoods of Bukit Duri and Kampung Melayu may be attributed to households. This is in part due to inadequate municipal waste infrastructure and services which has caused those living along the river to rely upon it for waste disposal. However, there has been little research to understand the prevalence of household waste along the river. Our aim is to develop a methodology that deploys a low cost sensor to identify point source discharge of solid waste using image classification methods. To demonstrate this we describe the following five-step method: 1) a strip of GoPro images are captured photogrammetrically and processed for dense point cloud generation; 2) depth for each image is generated through a backward projection of the point clouds; 3) a supervised image classification method based on Random Forest classifier is applied on the view dependent red, green, blue and depth (RGB-D) data; 4) point discharge locations of solid waste can then be mapped by projecting the classified images to the 3D point clouds; 5) then the landscape elements are classified into five types, such as vegetation, human settlement, soil, water and solid waste. While this work is still ongoing, the initial results have demonstrated that it is possible to perform quantitative studies that may help reveal and estimate the amount of waste present along the river bank.

  3. Understanding the Complexities of Subnational Incentives in Supporting a National Market for Distributed Photovoltaics

    Energy Technology Data Exchange (ETDEWEB)

    Bush, B.; Doris, E.; Getman, D.

    2014-09-01

    Subnational policies pertaining to photovoltaic (PV) systems have increased in volume in recent years and federal incentives are set to be phased out over the next few. Understanding how subnational policies function within and across jurisdictions, thereby impacting PV market development, informs policy decision making. This report was developed for subnational policy-makers and researchers in order to aid the analysis on the function of PV system incentives within the emerging PV deployment market. The analysis presented is based on a 'logic engine,' a database tool using existing state, utility, and local incentives allowing users to see the interrelationships between PV system incentives and parameters, such as geographic location, technology specifications, and financial factors. Depending on how it is queried, the database can yield insights into which combinations of incentives are available and most advantageous to the PV system owner or developer under particular circumstances. This is useful both for individual system developers to identify the most advantageous incentive packages that they qualify for as well as for researchers and policymakers to better understand the patch work of incentives nationwide as well as how they drive the market.

  4. Food, health, and complexity: towards a conceptual understanding to guide collaborative public health action

    Directory of Open Access Journals (Sweden)

    Shannon E. Majowicz

    2016-06-01

    Full Text Available Abstract Background What we eat simultaneously impacts our exposure to pathogens, allergens, and contaminants, our nutritional status and body composition, our risks for and the progression of chronic diseases, and other outcomes. Furthermore, what we eat is influenced by a complex web of drivers, including culture, politics, economics, and our built and natural environments. To date, public health initiatives aimed at improving food-related population health outcomes have primarily been developed within ‘practice silos’, and the potential for complex interactions among such initiatives is not well understood. Therefore, our objective was to develop a conceptual model depicting how infectious foodborne illness, food insecurity, dietary contaminants, obesity, and food allergy can be linked via shared drivers, to illustrate potential complex interactions and support future collaboration across public health practice silos. Methods We developed the conceptual model by first conducting a systematic literature search to identify review articles containing schematics that depicted relationships between drivers and the issues of interest. Next, we synthesized drivers into a common model using a modified thematic synthesis approach that combined an inductive thematic analysis and mapping to synthesize findings. Results The literature search yielded 83 relevant references containing 101 schematics. The conceptual model contained 49 shared drivers and 227 interconnections. Each of the five issues was connected to all others. Obesity and food insecurity shared the most drivers (n = 28. Obesity shared several drivers with food allergy (n = 11, infectious foodborne illness (n = 7, and dietary contamination (n = 6. Food insecurity shared several drivers with infectious foodborne illness (n = 9 and dietary contamination (n = 9. Infectious foodborne illness shared drivers with dietary contamination (n = 8. Fewer drivers were

  5. Effect of dust particle polarization on scattering processes in complex plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Kodanova, S. K.; Ramazanov, T. S.; Bastykova, N. Kh.; Moldabekov, Zh. A. [Institute for Experimental and Theoretical Physics, Al-Farabi Kazakh National University, 71 Al-Farabi Str., 050040 Almaty (Kazakhstan)

    2015-06-15

    Screened interaction potentials in dusty plasmas taking into account the polarization of dust particles have been obtained. On the basis of screened potentials scattering processes for ion-dust particle and dust particle-dust particle pairs have been studied. In particular, the scattering cross section is considered. The scattering processes for which the dust grain polarization is unimportant have been found. The effect of zero angle dust particle-dust particle scattering is predicted.

  6. Application of tomographic particle image velocimetry to studies of transport in complex (dusty) plasma

    International Nuclear Information System (INIS)

    Williams, Jeremiah D.

    2011-01-01

    Over the past twelve years, two-dimensional and stereoscopic particle image velocimetry (PIV) techniques have been used to obtain detailed measurements of the thermal and transport properties of the microparticle component of dusty plasma systems. This letter reports on an extension of these techniques to obtain a volumetric, three-dimensional velocity vector measurement using tomographic PIV. Initial measurements using the tomographic PIV diagnostic are presented.

  7. The facile synthesis of a chitosan Cu(II) complex by solution plasma process and evaluation of their antioxidant activities.

    Science.gov (United States)

    Ma, Fengming; Li, Pu; Zhang, Baiqing; Wang, Zhenyu

    2017-10-01

    Synthesis of chitosan-Cu(II) complex by solution plasma process (SPP) irradiation was investigated. The effects of the distance between the electrodes, initial Cu(II) concentration, and initial pH on the Cu(II) adsorption capacity were evaluated. The results showed that narrower distance between the electrodes, higher initial Cu(II) concentration and higher initial pH (at pHchitosan-Cu(II) complex by ultraviolet-visible (UV-vis), fourier transform infrared (FT-IR) and electron spin resonance (ESR) spectroscopy revealed that the main structure of chitosan was not changed after irradiation. Thermogravimetry (TG) analysis indicated that Cu(II) ions were well incorporated into the chitosan. The antioxidant activity of the chitosan-Cu(II) complex was evaluated by DPPH, ABTS, and reducing power assays. The chitosan-Cu(II) complex exhibited greater antioxidant activity than the original chitosan. Thus, SPP could be used for preparation of chitosan-Cu(II) complexes. Copyright © 2017. Published by Elsevier B.V.

  8. Physical Chemistry of Nanomedicine: Understanding the Complex Behaviors of Nanoparticles in Vivo

    Science.gov (United States)

    Lane, Lucas A.; Qian, Ximei; Smith, Andrew M.; Nie, Shuming

    2015-04-01

    Nanomedicine is an interdisciplinary field of research at the interface of science, engineering, and medicine, with broad clinical applications ranging from molecular imaging to medical diagnostics, targeted therapy, and image-guided surgery. Despite major advances during the past 20 years, there are still major fundamental and technical barriers that need to be understood and overcome. In particular, the complex behaviors of nanoparticles under physiological conditions are poorly understood, and detailed kinetic and thermodynamic principles are still not available to guide the rational design and development of nanoparticle agents. Here we discuss the interactions of nanoparticles with proteins, cells, tissues, and organs from a quantitative physical chemistry point of view. We also discuss insights and strategies on how to minimize nonspecific protein binding, how to design multistage and activatable nanostructures for improved drug delivery, and how to use the enhanced permeability and retention effect to deliver imaging agents for image-guided cancer surgery.

  9. Understanding the genetic and epigenetic architecture in complex network of rice flowering pathways.

    Science.gov (United States)

    Sun, Changhui; Chen, Dan; Fang, Jun; Wang, Pingrong; Deng, Xiaojian; Chu, Chengcai

    2014-12-01

    Although the molecular basis of flowering time control is well dissected in the long day (LD) plant Arabidopsis, it is still largely unknown in the short day (SD) plant rice. Rice flowering time (heading date) is an important agronomic trait for season adaption and grain yield, which is affected by both genetic and environmental factors. During the last decade, as the nature of florigen was identified, notable progress has been made on exploration how florigen gene expression is genetically controlled. In Arabidopsis expression of certain key flowering integrators such as FLOWERING LOCUS C (FLC) and FLOWERING LOCUS T (FT) are also epigenetically regulated by various chromatin modifications, however, very little is known in rice on this aspect until very recently. This review summarized the advances of both genetic networks and chromatin modifications in rice flowering time control, attempting to give a complete view of the genetic and epigenetic architecture in complex network of rice flowering pathways.

  10. Understanding the Effect of Gas Dynamics in Plasma Gun Performance for Simulating Fusion Wall Response to Disruption Events

    Science.gov (United States)

    Riedel, Will; Underwood, Thomas; Righetti, Fabio; Cappelli, Mark

    2017-10-01

    In this work, the suitability of a pulsed coaxial plasma accelerator to simulate the interaction of edge-localized modes with plasma first wall materials is investigated. Experimental measurements derived from a suite of diagnostics are presented that focus on both the properties of the plasma flow and the manner in which such jets couple with material interfaces. Specific emphasis is placed on quantifying the variation in these properties using tungsten tokens exposed to the plasma plume as the gun volume is progressively filled with more neutral gas. These results are mapped to the operational dynamics of the gun via a time-resolved Schlieren cinematic visualization of the density gradient within the flow. Resulting videos indicate the existence of two distinct modes with vastly different characteristic timescales, spatial evolution, and plasma properties. Time resolved quantification of the associated plasma heat flux for both modes, including a range spanning 150 MW m-2 - 10 GW m-2, is presented using both a fast thermocouple gauge and an IR camera. Both diagnostics in conjunction with a heat transfer model provide an accurate description of the energy transfer dynamics and operational characteristics of plasma guns. This work is supported by the U.S. Department of Energy Stewardship Science Academic Program.

  11. Using design principles to foster understanding of complex health concepts in consumer informatics tools.

    Science.gov (United States)

    Misra, Rupananda; Mark, Jessica H; Khan, Sharib; Kukafka, Rita

    2010-11-13

    Consumer health informatics tools can only be effective if patients comprehend their content. Optimal design may foster better patient comprehension and health literacy, which can improve health outcomes. We developed a patient-centric decision aid, Tailored Lifestyle Conversations (TLC), to help patients comprehend behavioral risks and set behavior change priorities for reducing risk of cardiovascular disease. The TLC decision aid was developed using a design framework based on Gestalt Principles of Perception. Further iteration was informed by qualitative user feedback. Preliminary analysis showed that the TLC decision aid helped patients understand their risk and supported their decisions on health behavior change. We identified design elements that supported patient comprehension, and other elements that were not effective, to inform iterative revision. This paper describes an effective methodology for the development of consumer health informatics tools that includes grounding in design principles complemented by iterative revision based on user testing and feedback.

  12. APPLICATION FOR 3D SCENE UNDERSTANDING IN DETECTING DISCHARGE OF DOMESTICWASTE ALONG COMPLEX URBAN RIVERS

    Directory of Open Access Journals (Sweden)

    Y. Ninsalam

    2016-06-01

    Full Text Available In our study we use 3D scene understanding to detect the discharge of domestic solid waste along an urban river. Solid waste found along the Ciliwung River in the neighbourhoods of Bukit Duri and Kampung Melayu may be attributed to households. This is in part due to inadequate municipal waste infrastructure and services which has caused those living along the river to rely upon it for waste disposal. However, there has been little research to understand the prevalence of household waste along the river. Our aim is to develop a methodology that deploys a low cost sensor to identify point source discharge of solid waste using image classification methods. To demonstrate this we describe the following five-step method: 1 a strip of GoPro images are captured photogrammetrically and processed for dense point cloud generation; 2 depth for each image is generated through a backward projection of the point clouds; 3 a supervised image classification method based on Random Forest classifier is applied on the view dependent red, green, blue and depth (RGB-D data; 4 point discharge locations of solid waste can then be mapped by projecting the classified images to the 3D point clouds; 5 then the landscape elements are classified into five types, such as vegetation, human settlement, soil, water and solid waste. While this work is still ongoing, the initial results have demonstrated that it is possible to perform quantitative studies that may help reveal and estimate the amount of waste present along the river bank.

  13. FuturICT: Participatory computing to understand and manage our complex world in a more sustainable and resilient way

    Science.gov (United States)

    Helbing, D.; Bishop, S.; Conte, R.; Lukowicz, P.; McCarthy, J. B.

    2012-11-01

    We have built particle accelerators to understand the forces that make up our physical world. Yet, we do not understand the principles underlying our strongly connected, techno-socio-economic systems. We have enabled ubiquitous Internet connectivity and instant, global information access. Yet we do not understand how it impacts our behavior and the evolution of society. To fill the knowledge gaps and keep up with the fast pace at which our world is changing, a Knowledge Accelerator must urgently be created. The financial crisis, international wars, global terror, the spreading of diseases and cyber-crime as well as demographic, technological and environmental change demonstrate that humanity is facing serious challenges. These problems cannot be solved within the traditional paradigms. Moving our attention from a component-oriented view of the world to an interaction-oriented view will allow us to understand the complex systems we have created and the emergent collective phenomena characterising them. This paradigm shift will enable new solutions to long-standing problems, very much as the shift from a geocentric to a heliocentric worldview has facilitated modern physics and the ability to launch satellites. The FuturICT flagship project will develop new science and technology to manage our future in a complex, strongly connected world. For this, it will combine the power of information and communication technology (ICT) with knowledge from the social and complexity sciences. ICT will provide the data to boost the social sciences into a new era. Complexity science will shed new light on the emergent phenomena in socially interactive systems, and the social sciences will provide a better understanding of the opportunities and risks of strongly networked systems, in particular future ICT systems. Hence, the envisaged FuturICT flagship will create new methods and instruments to tackle the challenges of the 21st century. FuturICT could indeed become one of the most

  14. Understanding complexities in coupled dynamics of human-water and food security

    Science.gov (United States)

    Usmani, M.; Kondal, A.; Lin, L.; Colwell, R. R.; Jutla, A.

    2017-12-01

    Traditional premise of food security is associated with satisfying human hunger by providing sufficient calories to population. Water is the key variable associated with the growth of crops, which is then used as a metric of success for abundance of food across globe. The current framework often negates complex coupled interaction between availability of food nutrients and human well-being (such as productivity, work efficiency, low birth weight, physical and mental growth). Our analysis suggests that 1 in 3 humans suffer from malnutrition across the globe. In last five decades, most of the countries have a decreasing availability trend in at least one of the twenty-three essential food nutrients required for human well-being. We argue that food security can only be achieved if information on use of water for crops and consumption of food must include availability of nutrients for humans. Here, we propose a new concept of "consumptive nutrients" that include constant feedback mechanism between water-human and societal processes- essential for growth, distribution and consumption of food nutrients. Using Ethiopia as a signature rain-fed agricultural region, we will show how decreasing precipitation has led to an increase in crop productivity, but decreased availability of nutrients for humans. This in turn has destabilizing impact on overall regional economy. We will demonstrate why inclusion of nutrients must be a part of discussion for ensuring food security to human population.

  15. Childhood disability in Turkana, Kenya: Understanding how carers cope in a complex humanitarian setting.

    Science.gov (United States)

    Zuurmond, Maria; Nyapera, Velma; Mwenda, Victoria; Kisia, James; Rono, Hilary; Palmer, Jennifer

    2016-01-01

    Although the consequences of disability are magnified in humanitarian contexts, research into the difficulties of caring for children with a disability in such settings has received limited attention. Based on in-depth interviews with 31 families, key informants and focus group discussions in Turkana, Kenya, this article explores the lives of families caring for children with a range of impairments (hearing, vision, physical and intellectual) in a complex humanitarian context characterised by drought, flooding, armed conflict, poverty and historical marginalisation. The challenging environmental and social conditions of Turkana magnified not only the impact of impairment on children, but also the burden of caregiving. The remoteness of Turkana, along with the paucity and fragmentation of health, rehabilitation and social services, posed major challenges and created opportunity costs for families. Disability-related stigma isolated mothers of children with disabilities, especially, increasing their burden of care and further limiting their access to services and humanitarian programmes. In a context where social systems are already stressed, the combination of these factors compounded the vulnerabilities faced by children with disabilities and their families. The needs of children with disabilities and their carers in Turkana are not being met by either community social support systems or humanitarian aid programmes. There is an urgent need to mainstream disability into Turkana services and programmes.

  16. Carbon-water Cycling in the Critical Zone: Understanding Ecosystem Process Variability Across Complex Terrain

    Energy Technology Data Exchange (ETDEWEB)

    Barnard, Holly [Univ. of Colorado, Boulder, CO (United States); Brooks, Paul [Univ. of Utah, Salt Lake City, UT (United States); Univ. of Arizona, Tucson, AZ (United States)

    2016-06-16

    One of the largest knowledge gaps in environmental science is the ability to understand and predict how ecosystems will respond to future climate variability. The links between vegetation, hydrology, and climate that control carbon sequestration in plant biomass and soils remain poorly understood. Soil respiration is the second largest carbon flux of terrestrial ecosystems, yet there is no consensus on how respiration will change as water availability and temperature co-vary. To address this knowledge gap, we use the variation in soil development and topography across an elevation and climate gradient on the Front Range of Colorado to conduct a natural experiment that enables us to examine the co-evolution of soil carbon, vegetation, hydrology, and climate in an accessible field laboratory. The goal of this project is to further our ability to combine plant water availability, carbon flux and storage, and topographically driven hydrometrics into a watershed scale predictive model of carbon balance. We hypothesize: (i) landscape structure and hydrology are important controls on soil respiration as a result of spatial variability in both physical and biological drivers: (ii) variation in rates of soil respiration during the growing season is due to corresponding shifts in belowground carbon inputs from vegetation; and (iii) aboveground carbon storage (biomass) and species composition are directly correlated with soil moisture and therefore, can be directly related to subsurface drainage patterns.

  17. Studying the complexity of change: toward an analytical framework for understanding deliberate social-ecological transformations

    Directory of Open Access Journals (Sweden)

    Michele-Lee Moore

    2014-12-01

    Full Text Available Faced with numerous seemingly intractable social and environmental challenges, many scholars and practitioners are increasingly interested in understanding how to actively engage and transform the existing systems holding such problems in place. Although a variety of analytical models have emerged in recent years, most emphasize either the social or ecological elements of such transformations rather than their coupled nature. To address this, first we have presented a definition of the core elements of a social-ecological system (SES that could potentially be altered in a transformation. Second, we drew on insights about transformation from three branches of literature focused on radical change, i.e., social movements, socio-technical transitions, and social innovation, and gave consideration to the similarities and differences with the current studies by resilience scholars. Drawing on these findings, we have proposed a framework that outlines the process and phases of transformative change in an SES. Future research will be able to utilize the framework as a tool for analyzing the alteration of social-ecological feedbacks, identifying critical barriers and leverage points and assessing the outcome of social-ecological transformations.

  18. Understanding the Complexities of Food Safety Using a "One Health" Approach.

    Science.gov (United States)

    Kniel, Kalmia E; Kumar, Deepak; Thakur, Siddhartha

    2018-02-01

    The philosophy of One Health is growing in concept and clarity. The interdependence of human, animal, and environmental health is the basis for the concept of One Health. One Health is a comprehensive approach to ensure the health of people, animals, and the environment through collaborative efforts. Preharvest food safety issues align with the grand concept of One Health. Imagine any food production system, and immediately, parallel images from One Health emerge: for example, transmission of zoonotic diseases, antibiotic residues, or resistance genes in the environment; environmental and animal host reservoirs of disease; challenges with rearing animals and growing fresh produce on the same farm; application and transport of manure or diseased animals. During a recent celebration of #OneHealthDay, information was shared around the globe concerning scientists dedicated to One Health research systems. An ever-growing trade and global commerce system mixed with our incessant desire for food products during the whole year makes it all the more important to take a global view through the One Health lens to solve these growing challenges. The recent explosion of Zika virus around the globe renewed the need for assessing transmissible diseases through the eyes of One Health. It is not good enough to know how a disease affects the human population without a thorough understanding of the environment and vector reservoirs. If 60 to 75% of infectious diseases affecting humans are of animal origin, the need for better One Health research strategies and overdue solutions is imperative.

  19. Understanding the complexities of functional ability in Alzheimer's disease: more than just basic and instrumental factors.

    Science.gov (United States)

    Kahle-Wrobleski, Kristin; Coley, Nicola; Lepage, Benoit; Cantet, Christelle; Vellas, Bruno; Andrieu, Sandrine

    2014-05-01

    Dementia of the Alzheimer's type (AD) is defined by both cognitive and functional decline; new criteria allow for identification of milder, non-functionally impaired patients. Understanding loss of autonomy in AD is essential, as later stages represent a significant burden and cost to patients, their families, and society. The purpose of the present analyses was to determine the factor structure of the Alzheimer's Disease Cooperative Study-Activities of Daily Living Scale (ADCS-ADL) in a cohort of AD patients. Baseline ADCS-ADL assessments of 734 AD patients from the PLASA study were included in an exploratory factor analysis (EFA). Because the ADCS-ADL was designed to assess change over time, change from baseline scores over 2 years were also analyzed using an EFA. Factorial solutions were evaluated based on cross-loading, non-loadings, and number of items per factor. Mean age at baseline was 79.3, mean MMSE was 19.8 and 73.3% of participants were female. Baseline data suggested a 4-factor solution that included factors for basic ADLs (BADLs), domestic/household activities, communication/engagement with the environment, and outside activities. The change scores EFA suggested a 2-factor solution of BADLs and instrumental ADLs (IADLs). Distinct factors of IADLs should be considered for further validation as areas of attention to catch early functional decline.

  20. Flow characteristics of bounded self-organized dust vortex in a complex plasma

    Science.gov (United States)

    Laishram, Modhuchandra; Sharma, D.; Chattopdhyay, P. K.; Kaw, P. K.

    2018-01-01

    Dust clouds are often formed in many dusty plasma experiments, when micron size dust particles introduced in the plasma are confined by spatial non-uniformities of the potential. These formations show self-organized patterns like vortex or circulation flows. Steady-state equilibrium dynamics of such dust clouds is analyzed by 2D hydrodynamics for varying Reynolds number, Re, when the cloud is confined in an azimuthally symmetric cylindrical setup by an effective potential and is in a dynamic equilibrium with an unbounded sheared plasma flow. The nonconservative forcing due to ion flow shear generates finite vorticity in the confined dust clouds. In the linear limit (Re ≪ 1), the collective flow is characterized by a single symmetric and elongated vortex with scales correlating with the driving field and those generated by friction with the boundaries. However in the high Re limit, (Re ≥ 1), the nonlinear inertial transport (u . ∇u) is effective and the vortex structure is characterized by an asymmetric equilibrium and emergence of a circular core region with uniform vorticity, over which the viscous stress is negligible. The core domain is surrounded by a virtual boundary of highly convective flow followed by thin shear layers filled with low-velocity co- and counter-rotating vortices, enabling the smooth matching with external boundary conditions. In linear regime, the effective boundary layer thickness is recovered to scale with the dust kinematic viscosity as Δr ≈ μ1/3 and is modified as Δr ≈ (μL∥/u)1/2 in the nonlinear regime through a critical kinematic viscosity μ∗ that signifies a structural bifurcation of the flow field solutions. The flow characteristics recovered are relevant to many microscopic biological processes at lower Re, as well as gigantic vortex flows such as Jovian great red spot and white ovals at higher Re.

  1. Childhood disability in Turkana, Kenya: Understanding how carers cope in a complex humanitarian setting

    Directory of Open Access Journals (Sweden)

    Maria Zuurmond

    2016-02-01

    Full Text Available Background: Although the consequences of disability are magnified in humanitarian contexts, research into the difficulties of caring for children with a disability in such settings has received limited attention.Methods: Based on in-depth interviews with 31 families, key informants and focus group discussions in Turkana, Kenya, this article explores the lives of families caring for children with a range of impairments (hearing, vision, physical and intellectual in a complex humanitarian context characterised by drought, flooding, armed conflict, poverty and historical marginalisation.Results: The challenging environmental and social conditions of Turkana magnified not only the impact of impairment on children, but also the burden of caregiving. The remoteness of Turkana, along with the paucity and fragmentation of health, rehabilitation and social services, posed major challenges and created opportunity costs for families. Disability-related stigma isolated mothers of children with disabilities, especially, increasing their burden of care and further limiting their access to services and humanitarian programmes. In a context where social systems are already stressed, the combination of these factors compounded the vulnerabilities faced by children with disabilities and their families.Conclusion: The needs of children with disabilities and their carers in Turkana are not being met by either community social support systems or humanitarian aid programmes. There is an urgent need to mainstream disability into Turkana services and programmes.

  2. Understanding complex coacervation in serum albumin and pectin mixtures using a combination of the Boltzmann equation and Monte Carlo simulation.

    Science.gov (United States)

    Li, Yunqi; Zhao, Qin; Huang, Qingrong

    2014-01-30

    A combination of turbidimetric titration, a sigmoidal Boltzmann equation approach and Monte Carlo simulation has been used to study the complex coacervation in serum albumin and pectin mixtures. The effects of the mass ratio of protein to polysaccharide on the critical pH values, the probability of complex coacervation and the electrostatic interaction from charge patches in serum albumin were investigated. Turbidimetric titration results showed an optimum pH for complex coacervation (pHm), which corresponded to the maximum turbidity in the protein/polysaccharide mixture. The pHm monotonically decreased as the ratio decreased, and could be fitted using the sigmoidal Boltzmann equation. It suggests that pHm could be a good ordering parameter to characterize the phase behavior associated with protein/polysaccharide complex coacervation. Qualitative understanding of pHm by taking into account the minimization of electrostatic interaction, as well as quantitative matching of pHm according to the concept of charge neutralization were both achieved. Our results suggest that the serum albumin/pectin complexes were ultimately neutralized by the partial charges originated from the titratable residues in protein and polysaccharide chains at pHm. The Monte Carlo simulation provided consistent phase boundaries for complex coacervation in the same system, and the intermolecular association strength was determined to be several kBT below the given ionic strength. The strongest binding site in the protein is convergent to the largest positive charge patch if pure electrostatic interaction was considered. Further inclusion of contribution from excluded volume resulted in the binding site distribution over five different positive charge patches at different protein/polysaccharide ratios and pH values. Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. Understanding the molecular-level chemistry of water plasmas and the effects of surface modification and deposition on a selection of oxide substrates

    Science.gov (United States)

    Trevino, Kristina J.

    2011-12-01

    , surface charge, and isoelectric point (IEP). The results demonstrate that 100% Ar, H2O, and NH3 plasma treatments cause changes in surface charge, wettability, and IEP values for all treated surfaces. Observed variations in these values depend primarily on the specific mechanism for surface functionalization with each plasma treatment. These results highlight the utility of IEP measurements for characterizing plasma treated surfaces and suggest the possibility that plasmas may provide a valuable means of controlling surface charge and wettability of metal oxides. The incorporation of functional groups on the surface of Zeolite X was also examined as an additional form of plasma surface modification. The intention of these studies was to (1) alter the surface functionality by simple plasmas treatments, as characterized by XPS data; (2) change the hydrophilic nature of the zeolite to be more hydrophobic with fluorocarbon plasmas; (3) gain total surface area functionality with our new rotating drum reactor; and (4) ensure that damage was not occurring to the zeolite structure, as evidenced by SEM images. Results showed the incorporation of different surface functionality was accomplished with all plasma systems studied (CF4, C2 F6, C3F8), the zeolite structure was not damaged by the plasma, and the potential for altering the entire surface area of these porous materials exists. The final portion of this dissertation addresses aspects of work designed to understand the adhesion behavior of amorphous carbon nitride (a-CN x) films deposited from a CH3CN and BrCN plasmas. In particular, films obtained from CH3CH plasmas stayed intact whereas BrCN plasmas produced films that delaminated upon their exposure to atmosphere. These results have been attributed to humidity, film stress, hydrocarbon species, and the Br content in the film. The major contributions to this work made here center on the chemical composition and binding environments of the deposited films as measured by XPS

  4. Plasma turbulence calculations on supercomputers

    International Nuclear Information System (INIS)

    Carreras, B.A.; Charlton, L.A.; Dominguez, N.; Drake, J.B.; Garcia, L.; Leboeuf, J.N.; Lee, D.K.; Lynch, V.E.; Sidikman, K.

    1991-01-01

    Although the single-particle picture of magnetic confinement is helpful in understanding some basic physics of plasma confinement, it does not give a full description. Collective effects dominate plasma behavior. Any analysis of plasma confinement requires a self-consistent treatment of the particles and fields. The general picture is further complicated because the plasma, in general, is turbulent. The study of fluid turbulence is a rather complex field by itself. In addition to the difficulties of classical fluid turbulence, plasma turbulence studies face the problems caused by the induced magnetic turbulence, which couples field by itself. In addition to the difficulties of classical fluid turbulence, plasma turbulence studies face the problems caused by the induced magnetic turbulence, which couples back to the fluid. Since the fluid is not a perfect conductor, this turbulence can lead to changes in the topology of the magnetic field structure, causing the magnetic field lines to wander radially. Because the plasma fluid flows along field lines, they carry the particles with them, and this enhances the losses caused by collisions. The changes in topology are critical for the plasma confinement. The study of plasma turbulence and the concomitant transport is a challenging problem. Because of the importance of solving the plasma turbulence problem for controlled thermonuclear research, the high complexity of the problem, and the necessity of attacking the problem with supercomputers, the study of plasma turbulence in magnetic confinement devices is a Grand Challenge problem

  5. Management of complex data flows in the ASDEX Upgrade plasma control system

    Energy Technology Data Exchange (ETDEWEB)

    Treutterer, Wolfgang, E-mail: Wolfgang.Treutterer@ipp.mpg.de [Max-Planck Institut fuer Plasmaphysik, EURATOM Association, Garching (Germany); Neu, Gregor; Raupp, Gerhard; Zasche, Dieter; Zehetbauer, Thomas [Max-Planck Institut fuer Plasmaphysik, EURATOM Association, Garching (Germany); Cole, Richard; Lueddecke, Klaus [Unlimited Computer Systems, Iffeldorf (Germany)

    2012-12-15

    Highlights: Black-Right-Pointing-Pointer Control system architectures with data-driven workflows are efficient, flexible and maintainable. Black-Right-Pointing-Pointer Signal groups provide coherence of interrelated signals and increase the efficiency of process synchronisation. Black-Right-Pointing-Pointer Sample tags indicating sample quality form the fundament of a local event handling strategy. Black-Right-Pointing-Pointer A self-organising workflow benefits from sample tags consisting of time stamp and stream activity. - Abstract: Establishing adequate technical and physical boundary conditions for a sustained nuclear fusion reaction is a challenging task. Phased feedback control and monitoring for heating, fuelling and magnetic shaping is mandatory, especially for fusion devices aiming at high performance plasmas. Technical and physical interrelations require close collaboration of many components in sequential as well as in parallel processing flows. Moreover, handling of asynchronous, off-normal events has become a key element of modern plasma performance optimisation and machine protection recipes. The manifoldness of plasma states and events, the variety of plant system operation states and the diversity in diagnostic data sampling rates can hardly be mastered with a rigid control scheme. Rather, an adaptive system topology in combination with sophisticated synchronisation and process scheduling mechanisms is suited for such an environment. Moreover, the system is subject to real-time control constraints: response times must be deterministic and adequately short. Therefore, the experimental tokamak device ASDEX Upgrade employs a discharge control system DCS, whose core has been designed to meet these requirements. In the paper we will compare the scheduling schemes for the parallelised realisation of a control workflow and show the advantage of a data-driven workflow over a managed workflow. The data-driven workflow as used in DCS is based on signals

  6. Management of complex data flows in the ASDEX Upgrade plasma control system

    International Nuclear Information System (INIS)

    Treutterer, Wolfgang; Neu, Gregor; Raupp, Gerhard; Zasche, Dieter; Zehetbauer, Thomas; Cole, Richard; Lüddecke, Klaus

    2012-01-01

    Highlights: ► Control system architectures with data-driven workflows are efficient, flexible and maintainable. ► Signal groups provide coherence of interrelated signals and increase the efficiency of process synchronisation. ► Sample tags indicating sample quality form the fundament of a local event handling strategy. ► A self-organising workflow benefits from sample tags consisting of time stamp and stream activity. - Abstract: Establishing adequate technical and physical boundary conditions for a sustained nuclear fusion reaction is a challenging task. Phased feedback control and monitoring for heating, fuelling and magnetic shaping is mandatory, especially for fusion devices aiming at high performance plasmas. Technical and physical interrelations require close collaboration of many components in sequential as well as in parallel processing flows. Moreover, handling of asynchronous, off-normal events has become a key element of modern plasma performance optimisation and machine protection recipes. The manifoldness of plasma states and events, the variety of plant system operation states and the diversity in diagnostic data sampling rates can hardly be mastered with a rigid control scheme. Rather, an adaptive system topology in combination with sophisticated synchronisation and process scheduling mechanisms is suited for such an environment. Moreover, the system is subject to real-time control constraints: response times must be deterministic and adequately short. Therefore, the experimental tokamak device ASDEX Upgrade employs a discharge control system DCS, whose core has been designed to meet these requirements. In the paper we will compare the scheduling schemes for the parallelised realisation of a control workflow and show the advantage of a data-driven workflow over a managed workflow. The data-driven workflow as used in DCS is based on signals connecting process outputs and inputs. These are implemented as real-time streams of data samples

  7. Complex Systems Are More than the Sum of Their Parts: Using Integration to Understand Performance, Biomechanics, and Diversity.

    Science.gov (United States)

    Kane, Emily A; Higham, Timothy E

    2015-07-01

    Organisms are comprised of many interacting parts, and an increased number or specialization of those parts leads to greater complexity and the necessity for increased integration (the ability of those parts to perform together and maintain a functioning organism). Although this idea is widely recognized among biologists, organisms are more tangibly studied when those parts are considered independently. This reductionist approach has successfully advanced our understanding of organisms' performance. However, performance of one system might (or might not) be dependent on performance of another system to achieve a relevant outcome, and the mechanism of this dependence is poorly understood. We synthesize the concepts of complexity and integration and discuss their application in a biomechanical context. Capture of prey by predatory fishes is used as an example to highlight the application of these ideas. We provide a theoretical framework for future hypotheses of integration and predict an "integration space" for fishes that is then populated with data extracted from the literature. Additionally, using the kinematics of prey-capture in two species of sculpin (Scorpaeniformes: Cottidae), we show that species exhibit multivariate integration in distinct ways, and that these differences add additional insight into ecological divergence that would not be apparent by considering systems independently. Finally, we discuss new insights into organismal performance gained through the study of integration as an emergent property of kinematic systems working together during a common task. Integration is rarely the trait of interest, but we show that future work should adopt a more holistic approach to understand why and how animals perform complex behaviors. © The Author 2015. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

  8. ELISA for evaluating the incorporation of plasma derived complement split-products C3b/iC3b into solid-phase immune complexes

    DEFF Research Database (Denmark)

    Zimmermann-Nielsen, E; Svehag, S E; Thorlacius-Ussing, O

    2001-01-01

    An ELISA that measures plasma derived complement (C) split-products C3b/iC3b deposited on solid-phase immune complexes during C activation is described. Plates are coated with BSA, anti-BSA and plasma is added. Deposited C3b/iC3b is then detected by biotinylated anti-C3c-antibodies, avidin...

  9. Plasmas for mankind and the understanding of the universe, from ITER to energy production, from laboratory to industry

    International Nuclear Information System (INIS)

    2006-01-01

    During this conference 16 guest papers have been presented dealing with various domains in which plasma physics plays a part: thermonuclear fusion, fuel cells, magnetic activities of stars, power laser interaction, Hall effect propulsion or particle acceleration. This document gathers most of the papers and about 60 posters

  10. Understanding Spatially Complex Segmental and Branch Anatomy Using 3D Printing: Liver, Lung, Prostate, Coronary Arteries, and Circle of Willis.

    Science.gov (United States)

    Javan, Ramin; Herrin, Douglas; Tangestanipoor, Ardalan

    2016-09-01

    Three-dimensional (3D) manufacturing is shaping personalized medicine, in which radiologists can play a significant role, be it as consultants to surgeons for surgical planning or by creating powerful visual aids for communicating with patients, physicians, and trainees. This report illustrates the steps in development of custom 3D models that enhance the understanding of complex anatomy. We graphically designed 3D meshes or modified imported data from cross-sectional imaging to develop physical models targeted specifically for teaching complex segmental and branch anatomy. The 3D printing itself is easily accessible through online commercial services, and the models are made of polyamide or gypsum. Anatomic models of the liver, lungs, prostate, coronary arteries, and the Circle of Willis were created. These models have advantages that include customizable detail, relative low cost, full control of design focusing on subsegments, color-coding potential, and the utilization of cross-sectional imaging combined with graphic design. Radiologists have an opportunity to serve as leaders in medical education and clinical care with 3D printed models that provide beneficial interaction with patients, clinicians, and trainees across all specialties by proactively taking on the educator's role. Complex models can be developed to show normal anatomy or common pathology for medical educational purposes. There is a need for randomized trials, which radiologists can design, to demonstrate the utility and effectiveness of 3D printed models for teaching simple and complex anatomy, simulating interventions, measuring patient satisfaction, and improving clinical care. Copyright © 2016 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

  11. Hot plasma and energetic particles in the earth's outer magnetosphere: new understandings during the IMS

    Energy Technology Data Exchange (ETDEWEB)

    Baker, D.N.; Fritz, T.A.

    1984-01-01

    In this paper we review the major accomplishments made during the IMS period in clarifying magnetospheric particle variations in the region from roughly geostationary orbit altitudes into the deep magnetotail. We divide our review into three topic areas: (1) acceleration processes; (2) transport processes; and (3) loss processes. Many of the changes in hot plasmas and energetic particle populations are often found to be related intimately to geomagnetic storm and magnetospheric substorm effects and, therefore, substantial emphasis is given to these aspects of particle variations in this review. The IMS data, taken as a body, allow a reasonably unified view as one traces magnetospheric particles from their acceleration source through the plasma sheet and outer trapping regions and, finally, to their loss via ionospheric precipitation and ring current formation processes. It is this underlying, unifying theme which is pursued here. 52 references, 19 figures.

  12. Understanding titanium-catalysed radical-radical reactions: a DFT study unravels the complex kinetics of ketone-nitrile couplings.

    Science.gov (United States)

    Streuff, Jan; Himmel, Daniel; Younas, Sara L

    2018-04-03

    The computational investigation of a titanium-catalysed reductive radical-radical coupling is reported. The results match the conclusions from an earlier experimental study and enable a further interpretation of the previously observed complex reaction kinetics. Furthermore, the interplay between neutral and cationic reaction pathways in titanium(iii)-catalysed reactions is investigated for the first time. The results show that hydrochloride additives and reaction byproducts play an important role in the respective equilibria. A full reaction profile is assembled and the computed activation barrier is found to be in reasonable agreement with the experiment. The conclusions are of fundamental importance to the field of low-valent titanium catalysis and the understanding of related catalytic radical-radical coupling reactions.

  13. Serum and plasma fibronectin binds to complement reacted immune complexes primarily via Clq

    DEFF Research Database (Denmark)

    Baatrup, G; Svehag, S E

    1986-01-01

    The binding of fibronectin to human Clq, C3b, and complement-reacted immune complexes (IC) was investigated by enzyme-linked immunosorbent assays. Microplates were coated with BSA followed by incubation with rabbit-anti-BSA IgG or F(ab')2 fragments of rabbit anti-BSA. Incubation of the solid phase...... with serum at 37 degrees C caused attachment of Clq and C3b. Addition of EDTA to the serum inhibited the binding of C3b, but not Clq, whereas substitution of the anti-BSA IgG on the solid phase with the F(ab')2 fragments abrogated the Clq, but not the C3b binding. Fibronectin binding was observed after...

  14. An Approach to Understanding Complex Socio-Economic Impacts and Responses to Climate Disruption in the Chesapeake Bay Region

    Science.gov (United States)

    Schaefer, R. K.; Nix, M.; Ihde, A. G.; Paxton, L. J.; Weiss, M.; Simpkins, S.; Fountain, G. H.; APl GAIA Team

    2011-12-01

    In this paper we describe the application of a proven methodology for modeling the complex social and economic interactions of a system under stress to the regional issues that are tied to global climate disruption. Under the auspices of the GAIA project (http://gaia.jhuapl.edu), we have investigated simulating the complex interplay between climate, politics, society, industry, and the environment in the Chesapeake Bay Watershed and associated geographic areas of Maryland, Virginia, and Pennsylvania. This Chesapeake Bay simulation draws on interrelated geophysical and climate models to support decision-making analysis about the Bay. In addition to physical models, however, human activity is also incorporated via input and output calculations. For example, policy implications are modeled in relation to business activities surrounding fishing, farming, industry and manufacturing, land development, and tourism. This approach fosters collaboration among subject matter experts to advance a more complete understanding of the regional impacts of climate change. Simulated interactive competition, in which teams of experts are assigned conflicting objectives in a controlled environment, allow for subject exploration which avoids trivial solutions that neglect the possible responses of affected parties. Results include improved planning, the anticipation of areas of conflict or high risk, and the increased likelihood of developing mutually acceptable solutions.

  15. Topological Characteristics of the Hong Kong Stock Market: A Test-based P-threshold Approach to Understanding Network Complexity

    Science.gov (United States)

    Xu, Ronghua; Wong, Wing-Keung; Chen, Guanrong; Huang, Shuo

    2017-02-01

    In this paper, we analyze the relationship among stock networks by focusing on the statistically reliable connectivity between financial time series, which accurately reflects the underlying pure stock structure. To do so, we firstly filter out the effect of market index on the correlations between paired stocks, and then take a t-test based P-threshold approach to lessening the complexity of the stock network based on the P values. We demonstrate the superiority of its performance in understanding network complexity by examining the Hong Kong stock market. By comparing with other filtering methods, we find that the P-threshold approach extracts purely and significantly correlated stock pairs, which reflect the well-defined hierarchical structure of the market. In analyzing the dynamic stock networks with fixed-size moving windows, our results show that three global financial crises, covered by the long-range time series, can be distinguishingly indicated from the network topological and evolutionary perspectives. In addition, we find that the assortativity coefficient can manifest the financial crises and therefore can serve as a good indicator of the financial market development.

  16. Understanding the dynamics of the Seguro Popular de Salud policy implementation in Mexico from a complex adaptive systems perspective.

    Science.gov (United States)

    Nigenda, Gustavo; González-Robledo, Luz María; Juárez-Ramírez, Clara; Adam, Taghreed

    2016-05-13

    In 2003, Mexico's Seguro Popular de Salud (SPS), was launched as an innovative financial mechanism implemented to channel new funds to provide health insurance to 50 million Mexicans and to reduce systemic financial inequities. The objective of this article is to understand the complexity and dynamics that contributed to the adaptation of the policy in the implementation stage, how these changes occurred, and why, from a complex and adaptive systems perspective. A complex adaptive systems (CAS) framework was used to carry out a secondary analysis of data obtained from four SPS's implementation evaluations. We first identified key actors, their roles, incentives and power, and their responses to the policy and guidelines. We then developed a causal loop diagram to disentangle the feedback dynamics associated with the modifications of the policy implementation which we then analyzed using a CAS perspective. Implementation variations were identified in seven core design features during the first 10 years of implementation period, and in each case, the SPS's central coordination introduced modifications in response to the reactions of the different actors. We identified several CAS phenomena associated with these changes including phase transitions, network emergence, resistance to change, history dependence, and feedback loops. Our findings generate valuable lessons to policy implementation processes, especially those involving a monetary component, where the emergence of coping mechanisms and other CAS phenomena inevitably lead to modifications of policies and their interpretation by those who implement them. These include the difficulty of implementing strategies that aim to pool funds through solidarity among beneficiaries where the rich support the poor when there are no incentives for the rich to do so. Also, how resistance to change and history dependence can pose significant challenges to implementing changes, where the local actors use their significant power

  17. Ecosystem function in complex mountain terrain: Combining models and long-term observations to advance process-based understanding

    Science.gov (United States)

    Wieder, William R.; Knowles, John F.; Blanken, Peter D.; Swenson, Sean C.; Suding, Katharine N.

    2017-04-01

    Abiotic factors structure plant community composition and ecosystem function across many different spatial scales. Often, such variation is considered at regional or global scales, but here we ask whether ecosystem-scale simulations can be used to better understand landscape-level variation that might be particularly important in complex terrain, such as high-elevation mountains. We performed ecosystem-scale simulations by using the Community Land Model (CLM) version 4.5 to better understand how the increased length of growing seasons may impact carbon, water, and energy fluxes in an alpine tundra landscape. The model was forced with meteorological data and validated with observations from the Niwot Ridge Long Term Ecological Research Program site. Our results demonstrate that CLM is capable of reproducing the observed carbon, water, and energy fluxes for discrete vegetation patches across this heterogeneous ecosystem. We subsequently accelerated snowmelt and increased spring and summer air temperatures in order to simulate potential effects of climate change in this region. We found that vegetation communities that were characterized by different snow accumulation dynamics showed divergent biogeochemical responses to a longer growing season. Contrary to expectations, wet meadow ecosystems showed the strongest decreases in plant productivity under extended summer scenarios because of disruptions in hydrologic connectivity. These findings illustrate how Earth system models such as CLM can be used to generate testable hypotheses about the shifting nature of energy, water, and nutrient limitations across space and through time in heterogeneous landscapes; these hypotheses may ultimately guide further experimental work and model development.

  18. Science Outside the Lab: Helping Graduate Students in Science and Engineering Understand the Complexities of Science Policy.

    Science.gov (United States)

    Bernstein, Michael J; Reifschneider, Kiera; Bennett, Ira; Wetmore, Jameson M

    2017-06-01

    Helping scientists and engineers challenge received assumptions about how science, engineering, and society relate is a critical cornerstone for macroethics education. Scientific and engineering research are frequently framed as first steps of a value-free linear model that inexorably leads to societal benefit. Social studies of science and assessments of scientific and engineering research speak to the need for a more critical approach to the noble intentions underlying these assumptions. "Science Outside the Lab" is a program designed to help early-career scientists and engineers understand the complexities of science and engineering policy. Assessment of the program entailed a pre-, post-, and 1 year follow up survey to gauge student perspectives on relationships between science and society, as well as a pre-post concept map exercise to elicit student conceptualizations of science policy. Students leave Science Outside the Lab with greater humility about the role of scientific expertise in science and engineering policy; greater skepticism toward linear notions of scientific advances benefiting society; a deeper, more nuanced understanding of the actors involved in shaping science policy; and a continued appreciation of the contributions of science and engineering to society. The study presents an efficacious program that helps scientists and engineers make inroads into macroethical debates, reframe the ways in which they think about values of science and engineering in society, and more thoughtfully engage with critical mediators of science and society relationships: policy makers and policy processes.

  19. Understanding the determinants of the complex interplay between cost-effectiveness and equitable impact in maternal and child mortality reduction.

    Science.gov (United States)

    Chopra, Mickey; Campbell, Harry; Rudan, Igor

    2012-06-01

    One of the most unexpected outcomes arising from the efforts towards maternal and child mortality reduction is that all too often the objective success has been coupled with increased inequity in the population. The aim of this study is to analyze the determinants of the complex interplay between cost-effectiveness and equity and suggest strategies that will promote an impact on mortality that reduce population child health inequities. We developed a conceptual framework that exposes the nature of the links between the five key determinants that need to be taken into account when planning equitable impact. These determinants are: (i) efficiency of intervention scale-up (requires knowledge of differential increase in cost of intervention scale-up by equity strata in the population); (ii) effectiveness of intervention (requires understanding of differential effectiveness of interventions by equity strata in the population); (iii) the impact on mortality (requires knowledge of differential mortality levels by equity strata, and understanding the differences in cause composition of overall mortality in different equity strata); (iv) cost-effectiveness (compares the initial cost and the resulting impact on mortality); (v) equity structure of the population. The framework is presented visually as a four-quadrant graph. We use the proposed framework to demonstrate why the relationship between cost-effectiveness and equitable impact of an intervention cannot be intuitively predicted or easily planned. The relationships between the five determinants are complex, often nonlinear, context-specific and intervention-specific. We demonstrate that there will be instances when an equity-promoting approach, ie, trying to reach for the poorest and excluded in the population with health interventions, will also be the most cost-effective approach. However, there will be cases in which this will be entirely unfeasible, and where equity-neutral or even inequity-promoting approaches may

  20. Understanding Magmatic Timescales and Magma Dynamics in Proterozoic Anorthosites: a Geochronological Investigation of the Kunene Complex (Angola)

    Science.gov (United States)

    Brower, A. M.; Corfu, F.; Bybee, G. M.; Lehmann, J.; Owen-Smith, T.

    2016-12-01

    The Kunene Anorthosite Complex, located in south west Angola, is one of the largest massif-type anorthosite intrusions on Earth, with an areal extent of at least 18 000 km2. Previous studies considered the Complex to consist of a series of coalesced plutons. However, the ages and relative emplacement sequence of these plutons are unknown. Understanding the relative timing of the pluton emplacement is crucial for understanding how these enigmatic magmas form and how they rise through the crust. Here we present new high precision U-Pb ID-TIMS ages (n=10) on zircons and baddeleyites for many of the coalesced plutons across the 300-km-long anorthositic complex. These new geochronological results reveal subtle variations in crystallization age between the coalesced plutons. There is no gradual age progression between plutons, but distinct groupings of ages (Fig.1). Age clusters of 1379.8 ± 2 Ma (n=5) occur north of the Red Granite NE-SW-striking intrusions, whereas in the south there is an older age grouping of 1390.4 ± 2.3 (n=3). Two additional ages of 1400.5 ± 1.3 in the centre and 1438.4 ± 1.1 Ma in the south east have been obtained. These results indicate that the Kunene anorthosites were emplaced over 60 Ma and may suggest long-lived magmatic systems and/or slowly ascending plutons. We also find a link between pluton composition and age. In general, leuconoritic domains are older than the leucotroctolitic domains. This may imply that the first pulses of magma received a greater degree of contamination, forcing the broadly basaltic magma to produce orthopyroxene as the main mafic phase. The later pulses receive less contamination as they ascend through the already partially melted crust, producing olivine as the mafic phase and deforming the older domains. This study reiterates the multiphase petrogenesis of Proterozoic anorthosites and sheds light on the assembly of crystal-rich magmas as they ascend through the crust.

  1. Computational plasma physics

    International Nuclear Information System (INIS)

    Killeen, J.

    1975-08-01

    The behavior of a plasma confined by a magnetic field is simulated by a variety of numerical models. Some models used on a short time scale give detailed knowledge of the plasma on a microscopic scale, while other models used on much longer time scales compute macroscopic properties of the plasma dynamics. In the last two years there has been a substantial increase in the numerical modelling of fusion devices. The status of MHD, transport, equilibrium, stability, Vlasov, Fokker-Planck, and Hybrid codes is reviewed. These codes have already been essential in the design and understanding of low and high beta toroidal experiments and mirror systems. The design of the next generation of fusion experiments and fusion test reactors will require continual development of these numerical models in order to include the best available plasma physics description and also to increase the geometric complexity of the model. (auth)

  2. Understanding of hysteresis behaviors at the L-H-L transitions in tokamak plasma based on bifurcation concept

    Energy Technology Data Exchange (ETDEWEB)

    Chatthong, B. [Department of Physics, Faculty of Science, Prince of Songkla University, Hat Yai, Songkla (Thailand); Onjun, T. [School of Manufacturing Systems and Mechanical Engineering, Sirindhorn International Institute of Technology, Thammasat University, Pathum Thani (Thailand)

    2016-08-15

    The hysteresis behaviour at the L-H-L transitions in tokamak plasma is investigated based on bifurcation concept. The formation of an edge transport barrier (ETB) is modeled via thermal and particle transport equations with the flow shear suppression effect on anomalous transport included. The anomalous transport is modeled based on critical gradients threshold and the flow shear is calculated from the force balance equation, couples the two transport equations leading to a non-linear behaviour. Analytical investigation reveals that the fluxes versus gradients space exhibits bifurcation behaviour with s -curve soft bifurcation type. Apparently, the backward H-L transition occurs at lower values than that of the forward L-H transition, illustrating hysteresis behaviour. The hysteresis properties, i.e. locations of threshold fluxes, gradients and their ratios are analyzed as a function of neoclassical and anomalous transport values and critical gradients. It is found that the minimum heat flux for maintaining H -mode depends on several plasma parameters including the strength of anomalous transport and neoclassical transport. In particular, the hysteresis depth becomes larger when neoclassical transport decreases or anomalous transport increases. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  3. Dusty plasmas

    International Nuclear Information System (INIS)

    Jones, M.E.; Winske, D.; Keinigs, R.; Lemons, D.

    1996-01-01

    This is the final report of a three-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The objective of this project has been to develop a fundamental understanding of dusty plasmas at the Laboratory. While dusty plasmas are found in space in galactic clouds, planetary rings, and cometary tails, and as contaminants in plasma enhanced fabrication of microelectronics, many of their properties are only partially understood. Our work has involved both theoretical analysis and self-consistent plasma simulations to understand basic properties of dusty plasmas related to equilibrium, stability, and transport. Such an understanding can improve the control and elimination of plasma dust in industrial applications and may be important in the study of planetary rings and comet dust tails. We have applied our techniques to the study of charging, dynamics, and coagulation of contaminants in plasma processing reactors for industrial etching and deposition processes and to instabilities in planetary rings and other space plasma environments. The work performed in this project has application to plasma kinetics, transport, and other classical elementary processes in plasmas as well as to plasma waves, oscillations, and instabilities

  4. The renewable energy industry in Massachussetts as a complex system: Developing a shared understanding for policy making

    Science.gov (United States)

    Jones, Charles A.

    A model-based field study was conducted to understand the mental models of participants in the photovoltaic industry in Massachusetts, with the purpose of understanding of how that industry works as a complex system. Mental models of industry participants are important, both as the holders of the best system information and as the critical actors in any policy solution. Experts from manufacturing, installation, development, policy, and advocacy sectors were interviewed. The knowledge they conveyed was expressed as a set system dynamics models; these models were characterized, compared, and combined in order to answer the following research questions: What are the mental models of participants? How widely are mental models shared among participants? What is the combined model of the system? How accurate are these models? Given these models, what policies would lead to success? The system described by informants is revealed as one of distributed and embedded agency---actors have the ability to take meaningful action, but that action and its effects are limited by the complexity of the system and by the actions of other actors. Both the growth of the industry and constraints on the growth occur through dynamic processes, many however outside local control. Mental models are shared in clusters of informants, with some differences between these groupings. Informants vary on the level of aggregation needed to express their descriptions and on the most important dynamic force. However, many processes are commonly perceived across informants, they perceive the same system trajectories, and the behavior of the simulation models constructed from their mental models was similar. A combined model was constructed which included a full range of potential feedback loops within an abstracted version of the described system. Testing for policy using the combined model reveals that the structures necessary for growth are present, as expected. Under several reasonable conditions

  5. Characterization and biotransformation in the plasma and red blood cells of V(IV)O(2+) complexes formed by ceftriaxone.

    Science.gov (United States)

    Sanna, Daniele; Fabbri, Davide; Serra, Maria; Buglyó, Péter; Bíró, Linda; Ugone, Valeria; Micera, Giovanni; Garribba, Eugenio

    2015-06-01

    The coordination mode and geometry in aqueous solution of oxidovanadium(IV) complexes formed by a third-generation cephalosporin, ceftriaxone (H3cef), were studied by spectroscopic (EPR, electron paramagnetic resonance), pH-potentiometric and computational (DFT, density functional theory) methods. The behavior of the model systems containing 6-hydroxy-2-methyl-3-thioxo-3,4-dihydro-1,2,4-triazine-5(2H)-one (H2hmtdt) and 3-benzylthio-6-hydroxy-2-methyl-1,2,4-triazine-5(2H)-one (Hbhmt) was examined for comparison. The stability of the tautomers of ceftriaxone and 6-hydroxy-2-methyl-3-thioxo-3,4-dihydro-1,2,4-triazine-5(2H)-one in the neutral, mono- and bi-anionic form was calculated by DFT methods, both in the gas phase and in aqueous solution, and the electron density on the oxygen atoms of the hydroxytriazinone ring was related to the pKa of the ligands. The data demonstrate that ceftriaxone coordinates V(IV)O(2+) forming mono- and bis-chelated complexes with (Oket, O(-)) donor set and formation of five-membered chelate rings. The geometry of the bis-chelated complex, cis-[VO(Hcef)2(H2O)](2-), is cis-octahedral and this species can deprotonate, around physiological pH, to form the corresponding mono-hydroxido cis-[VO(Hcef)2(OH)](3-). The interaction of cis-[VO(Hcef)2(H2O)](2-) with apo-transferrin (apo-hTf) was studied and the results suggest that V(IV)O(2+) distributes between (VO)apo-hTf/(VO)2apo-hTf and cis-[VO(Hcef)2(H2O)](2-), whereas mixed complexes are not formed for charge and steric effects. The interaction of cis-[VO(Hcef)2(H2O)](2-) with red blood cells shows that ceftriaxone helps V(IV)O(2+) ion to cross the erythrocyte membrane. Inside the cell cis-[VO(Hcef)2(H2O)](2-) decomposes and the same species formed by inorganic V(IV)O(2+) are observed. The relationship between the biotransformation in the plasma and red blood cells and the potential pharmacological activity of V(IV)O(2+) species of ceftriaxone is finally discussed. Copyright © 2015 Elsevier

  6. Complex regional pain syndrome and dysautonomia in a 14-year-old girl responsive to therapeutic plasma exchange.

    Science.gov (United States)

    Hendrickson, Jeanne E; Hendrickson, Emma T; Gehrie, Eric A; Sidhu, Davinder; Wallukat, Gerd; Schimke, Ingolf; Tormey, Christopher A

    2016-08-01

    Reflex sympathetic dystrophy, also known as complex regional pain syndrome (CRPS), has recently been shown to be associated with autoantibodies against β2-adrenergic and muscarinic M2 receptors. In addition to pain and sudomotor/vasomotor symptoms, dysautonomia is also observed in a subset of CRPS patients. Despite its severity, there are few effective therapies for CRPS described to date. We report a case of a 14-year-old girl with CRPS of her right leg and dysautonomia (gastroparesis, postural tachycardia) refractory to multiple therapies, successfully treated with therapeutic plasma exchange (TPE) with albumin replacement. The patient, who has serum anti β2-adrenergic and muscarinic M2 receptor autoantibodies in addition to nicotinic acetylcholine receptor ganglionic autoantibodies, underwent an initial course of five TPEs over a 2-week period. She demonstrated a clinical response to TPE as manifested by a rapid improvement in her fatigue and gastroparesis, with a gradual yet significant improvement in her leg pain and sudomotor/vasomotor flares. Following the loading procedures, the patient was treated with rituximab. She continues to require periodic TPE to maintain a remission, with additional immunosuppression being considered long term. Although further studies are needed, TPE (in combination with immunosuppression) may be an appropriate therapy for CRPS patients with detectable autoantibodies, as it is for better characterized diseases with autoantibodies against neuronal surface receptors such as myasthenia gravis or Lambert Eaton myasthenic syndrome. J. Clin. Apheresis 31:368-374, 2016. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

  7. Atomic scale simulation of H2O2 permeation through aquaporin: toward the understanding of plasma cancer treatment

    Science.gov (United States)

    Yusupov, Maksudbek; Yan, Dayun; Cordeiro, Rodrigo M.; Bogaerts, Annemie

    2018-03-01

    Experiments have demonstrated the potential selective anticancer capacity of cold atmospheric plasmas (CAPs), but the underlying mechanisms remain unclear. Using computer simulations, we try to shed light on the mechanism of selectivity, based on aquaporins (AQPs), i.e. transmembrane protein channels transferring external H2O2 and other reactive oxygen species, created e.g. by CAPs, to the cell interior. Specifically, we perform molecular dynamics simulations for the permeation of H2O2 through AQP1 (one of the members of the AQP family) and the palmitoyl-oleoyl-phosphatidylcholine (POPC) phospholipid bilayer (PLB). The free energy barrier of H2O2 across AQP1 is lower than for the POPC PLB, while the permeability coefficient, calculated using the free energy and diffusion rate profiles, is two orders of magnitude higher. This indicates that the delivery of H2O2 into the cell interior should be through AQP. Our study gives a better insight into the role of AQPs in the selectivity of CAPs for treating cancer cells.

  8. N-terminal arginines modulate plasma-membrane localization of Kv7.1/KCNE1 channel complexes.

    Directory of Open Access Journals (Sweden)

    Zenawit Girmatsion

    Full Text Available BACKGROUND AND OBJECTIVE: The slow delayed rectifier current (I(Ks is important for cardiac action potential termination. The underlying channel is composed of Kv7.1 α-subunits and KCNE1 β-subunits. While most evidence suggests a role of KCNE1 transmembrane domain and C-terminus for the interaction, the N-terminal KCNE1 polymorphism 38G is associated with reduced I(Ks and atrial fibrillation (a human arrhythmia. Structure-function relationship of the KCNE1 N-terminus for I(Ks modulation is poorly understood and was subject of this study. METHODS: We studied N-terminal KCNE1 constructs disrupting structurally important positively charged amino-acids (arginines at positions 32, 33, 36 as well as KCNE1 constructs that modify position 38 including an N-terminal truncation mutation. Experimental procedures included molecular cloning, patch-clamp recording, protein biochemistry, real-time-PCR and confocal microscopy. RESULTS: All KCNE1 constructs physically interacted with Kv7.1. I(Ks resulting from co-expression of Kv7.1 with non-atrial fibrillation '38S' was greater than with any other construct. Ionic currents resulting from co-transfection of a KCNE1 mutant with arginine substitutions ('38G-3xA' were comparable to currents evoked from cells transfected with an N-terminally truncated KCNE1-construct ('Δ1-38'. Western-blots from plasma-membrane preparations and confocal images consistently showed a greater amount of Kv7.1 protein at the plasma-membrane in cells co-transfected with the non-atrial fibrillation KCNE1-38S than with any other construct. CONCLUSIONS: The results of our study indicate that N-terminal arginines in positions 32, 33, 36 of KCNE1 are important for reconstitution of I(Ks. Furthermore, our results hint towards a role of these N-terminal amino-acids in membrane representation of the delayed rectifier channel complex.

  9. Effects of Rutin and Hesperidin and Their Al(III and Cu(II Complexes on in Vitro Plasma Coagulation Assays

    Directory of Open Access Journals (Sweden)

    Vesna Kuntić

    2011-02-01

    Full Text Available Two flavonoids, rutin and hesperidin, were investigated in vitro for anticoagulant activity through coagulation tests: activated partial thromboplastin time (aPTT, prothrombin time (PT and thrombin time (TT. Only an ethanolic solution of rutin at the concentration of 830 µM prolonged aPTT, while TT and PT were unaffected. In order to evaluate whether the prolongation of aPTT was due to the decrease of coagulation factors, the experiment with deficient plasma was performed, showing the effects on factors VIII and IX. Since pharmacological activity of flavonoids is believed to increase when they are coordinated with metal ions, complexes of these flavonoids with Al(III and Cu(II ions were also tested. The results showed that complexes significantly prolonged aPTT and had no effects on PT and TT. Assay with deficient plasma (plasma having the investigated factor at less then 1% revealed that complexes could bind to the coagulation factors, what may lead to a non-specific inhibition and aPTT prolongation. An effort was made to correlate stability of complexes with their anticoagulant properties.

  10. ELISA for evaluating the incorporation of plasma derived complement split-products C3b/iC3b into solid-phase immune complexes

    DEFF Research Database (Denmark)

    Zimmermann-Nielsen, E; Svehag, S E; Thorlacius-Ussing, O

    2001-01-01

    An ELISA that measures plasma derived complement (C) split-products C3b/iC3b deposited on solid-phase immune complexes during C activation is described. Plates are coated with BSA, anti-BSA and plasma is added. Deposited C3b/iC3b is then detected by biotinylated anti-C3c-antibodies, avidin......) or classical pathway (CP) with regard to age or gender was demonstrated. The total coefficient of variation was ELISA procedure was compared to a standard hemolytic complement CH(50) assay using plasma from 23 out-patients with systemic lupus erythematosus (SLE). There was a weak correlation between...... the two assays for both C pathways, but neither the ELISA nor the CH(50) assay showed any correlation with the diagnostic ACR-criteria for SLE. However, the capacity of the CP was significantly reduced in SLE out-patients compared to healthy blood donors (P

  11. Whimsicality of multi-mode Hasegawa space-charge waves in a complex plasma containing collision-dominated electrons and streaming ions

    Science.gov (United States)

    Lee, Myoung-Jae; Jung, Young-Dae

    2017-09-01

    The influence of collision-dominated electrons on multi-mode Hasegawa space-charge waves are investigated in a complex plasma containing streaming ions. The dispersion relation for the multi-mode Hasegawa space-charge wave propagating in a cylindrical waveguide filled with dusty plasma containing collision-dominated electrons and streaming ions is derived by using the fluid equations and Poisson’s equation which lead to a Bessel equation. By the boundary condition, the roots of the Bessel function would characterize the property of space-charge wave propagation. It is found that two solutions exist for wave frequency, which are affected by the radius of waveguide and the roots of the Bessel function. The damping and growing modes are found to be enhanced by an increase of the radius. However, an increase of electron collision frequency would suppress the damping and the growing modes of the propagating space-charge wave in a cylindrical waveguide plasma.

  12. Measurement of the ion drag force on falling dust particles and its relation to the void formation in complex (dusty) plasmas

    International Nuclear Information System (INIS)

    Zafiu, C.; Melzer, A.; Piel, A.

    2003-01-01

    Experiments on the quantitative determination of the weaker forces (ion drag, thermophoresis, and electric field force) on free-falling dust particles in a rf discharge tube are presented. The strongest force, gravity, is balanced by gas friction and the weaker forces are investigated in the radial (horizontal) plane. Under most discharge conditions, the particles are found to be expelled from the central plasma region. A transition to a situation where the falling particles are focused into the plasma center is observed at low gas pressures using small particles. These investigations allow a quantitative understanding of the mechanism of unwanted dust-free areas (so-called voids) in dusty plasmas under microgravity. Good quantitative agreement with standard models of the ion drag is found

  13. Plasma physics

    CERN Document Server

    Drummond, James E

    1961-01-01

    A historic snapshot of the field of plasma physics, this fifty-year-old volume offers an edited collection of papers by pioneering experts in the field. In addition to assisting students in their understanding of the foundations of classical plasma physics, it provides a source of historic context for modern physicists. Highly successful upon its initial publication, this book was the standard text on plasma physics throughout the 1960s and 70s.Hailed by Science magazine as a ""well executed venture,"" the three-part treatment ranges from basic plasma theory to magnetohydrodynamics and microwa

  14. Stochastic heating of dust particles in complex plasmas as an energetic instability of a harmonic oscillator with random frequency

    Energy Technology Data Exchange (ETDEWEB)

    Marmolino, Ciro [Dipartimento di Scienze e Tecnologie dell' Ambiente e del Territorio-DiSTAT, Universita del Molise, Contrada Fonte Lappone, I-86090 Pesche (Italy)

    2011-10-15

    The paper describes the occurrence of stochastic heating of dust particles in dusty plasmas as an energy instability due to the correlations between dust grain charge and electric field fluctuations. The possibility that the mean energy (''temperature'') of dust particles can grow in time has been found both from the self-consistent kinetic description of dusty plasmas taking into account charge fluctuations [U. de Angelis, A. V. Ivlev, V. N. Tsytovich, and G. E. Morfill, Phys. Plasmas 12(5), 052301 (2005)] and from a Fokker-Planck approach to systems with variable charge [A. V. Ivlev, S. K. Zhdanov, B. A. Klumov, and G. E. Morfill, Phys. Plasmas 12(9), 092104 (2005)]. Here, a different derivation is given by using the mathematical techniques of the so called multiplicative stochastic differential equations. Both cases of ''fast'' and ''slow'' fluctuations are discussed.

  15. Soluble 1:1 complexes and insoluble 3:2 complexes - Understanding the phase-solubility diagram of hydrocortisone and γ-cyclodextrin

    DEFF Research Database (Denmark)

    Schönbeck, Christian; Madsen, Tobias Løvgren; Peters, Günther H.

    2017-01-01

    -cyclodextrin in solution and the solid phase. The drug-solubilizer interaction was also studied by isothermal titration calorimetry from which a precise value of the 1:1 binding constant (K 11 =4.01mM-1 at 20°C) was obtained. The formation of water-soluble 1:1 complexes is responsible for the initial increase...

  16. The Comparison of the Skill of Understanding Complex Syntax at Children Attending to a Preschool Education Institution (TRNC-TR Sample)

    Science.gov (United States)

    Yazici, Elçin

    2016-01-01

    The current study was carried out to compare the skills of understanding complex syntax at children attending to preschool education institutions. In the current study, relational screening model, a model providing to determine the current study, was used. The working group of the study was made up of 224 children at the age of 4-5 attending to a…

  17. The CDC50A extracellular domain is required for forming a functional complex with and chaperoning phospholipid flippases to the plasma membrane.

    Science.gov (United States)

    Segawa, Katsumori; Kurata, Sachiko; Nagata, Shigekazu

    2018-02-09

    Flippases are enzymes that translocate phosphatidylserine (PtdSer) and phosphatidylethanolamine (PtdEtn) from the outer to the inner leaflet in the lipid bilayer of the plasma membrane, leading to the asymmetric distribution of aminophospholipids in the membrane. One mammalian phospholipid flippase at the plasma membrane is ATP11C, a type IV P-type ATPase (P4-ATPase) that forms a heterocomplex with the transmembrane protein CDC50A. However, the structural features in CDC50A that support the function of ATP11C and other P4-ATPases have not been characterized. Here, using error-prone PCR-mediated mutagenesis of human CDC50A cDNA followed by functional screening and deep sequencing, we identified 14 amino acid residues that affect ATP11C's flippase activity. These residues were all located in CDC50A's extracellular domain and were evolutionarily well-conserved. Most of the mutations decreased CDC50A's ability to chaperone ATP11C and other P4-ATPases to their destinations. The CDC50A mutants failed to form a stable complex with ATP11C and could not induce ATP11C's PtdSer-dependent ATPase activity. Notably, one mutant variant could form a stable complex with ATP11C and transfer ATP11C to the plasma membrane, yet the ATP11C complexed with this CDC50A variant had very weak or little PtdSer- or PtdEtn-dependent ATPase activity. These results indicated that the extracellular domain of CDC50A has important roles both in CDC50A's ability to chaperone ATP11C to the plasma membrane and in inducing ATP11C's ATP hydrolysis-coupled flippase activity. © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.

  18. Nuclear inelastic scattering and density-functional-theory calculations on the understanding of the vibronic properties of polynuclear iron complexes

    International Nuclear Information System (INIS)

    Faus, Isabelle

    2015-01-01

    Transition metal complexes of 3d elements with an electronic configuration of d 4 to d 8 can show a temperature dependent spin transition. This process is called spin crossover (SCO) effect and describes the transition between two states, the low spin (LS) state and the high spin (HS) state. In the LS state the spin is as low as possible, caused by none or a minimal number of unpaired electrons. In the HS state the spin is as high as possible with a maximal number of unpaired electrons. Because of this bistability, SCO materials are promising candidates for innovative molecular storage devices. Directly related to the SCO effect is the cooperativity, which specifies the interaction of metal centers between molecules (intermolecular cooperativity) or in a molecule (intramolecular cooperativity). Cooperativity is of vital importance for the switching behavior of SCO complexes with broad hysteresis. Therefore, three dinuclear SCO complexes which show a varying degree of cooperativity due to different geometries of their bridging ligands were investigated. By means of nuclear inelastic scattering (NIS), it could be clarified whether it is possible to find intramolecular cooperative effects in the vibrational patterns of these complexes. With corresponding density functional theory (DFT) calculations, it was possible for all of the dinuclear complexes to correlate the experimental NIS bands to the corresponding molecular vibrational modes. In the LS-LS or HS-HS state of the three complexes two modes exist lying energetically close together, which show a similar movement of the whole complex, with only a difference in the movement of the iron atoms. Thereby, the irons are moving either in the same or in the opposite direction. For complexes with a high degree of cooperativity there are nearly exclusively small energy shifts between this kind of nearly twofold energetically degenerated modes (ΔE <7 cm -1 ), for the complex with a low degree of cooperativity there are

  19. Chaos and Structures in Nonlinear Plasmas

    Science.gov (United States)

    Chen, James

    In recent decades, the concepts and applications of chaos, complexity, and nonlinear dynamics have profoundly influenced scientific as well as literary thinking. Some aspects of these concepts are used in almost all of the geophysical disciplines. Chaos and Structures in Nonlinear Plasmas, written by two respected plasma physicists, focuses on nonlinear phenomena in laboratory and space plasmas, which are rich in nonlinear and complex collective effects. Chaos is treated only insofar as it relates to some aspects of nonlinear plasma physics.At the outset, the authors note that plasma physics research has made fundamental contributions to modern nonlinear sciences. For example, the Poincare surface of section technique was extensively used in studies of stochastic field lines in magnetically confined plasmas and turbulence. More generally, nonlinearity in plasma waves and wave-wave and wave-particle interactions critically determines the propagation of energy through a plasma medium. The book also makes it clear that the importance of understanding nonlinear waves goes beyond plasma physics, extending to such diverse fields as solid state physics, fluid dynamics, atmospheric physics, and optics. In space physics, non-linear plasma physics is essential for interpreting in situ as well as remote-sensing data.

  20. Expression, purification, crystallization and preliminary X-ray analysis of calmodulin in complex with the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8

    International Nuclear Information System (INIS)

    Tidow, Henning; Hein, Kim L.; Baekgaard, Lone; Palmgren, Michael G.; Nissen, Poul

    2010-01-01

    Plant plasma-membrane Ca 2+ -ATPase is regulated via binding of calmodulin to its autoinhibitory N-terminal domain. In this study, the expression, purification, crystallization and preliminary X-ray diffraction analysis of this protein complex from A. thaliana are reported. Plasma-membrane Ca 2+ -ATPases (PMCAs) are calcium pumps that expel Ca 2+ from eukaryotic cells to maintain overall Ca 2+ homoeostasis and to provide local control of intracellular Ca 2+ signalling. They are of major physiological importance, with different isoforms being essential, for example, for presynaptic and postsynaptic Ca 2+ regulation in neurons, feedback signalling in the heart and sperm motility. In the resting state, PMCAs are autoinhibited by binding of their C-terminal (in mammals) or N-terminal (in plants) tail to two major intracellular loops. Activation requires the binding of calcium-bound calmodulin (Ca 2+ -CaM) to this tail and a conformational change that displaces the autoinhibitory tail from the catalytic domain. The complex between calmodulin and the regulatory domain of the plasma-membrane Ca 2+ -ATPase ACA8 from Arabidopsis thaliana has been crystallized. The crystals belonged to space group C2, with unit-cell parameters a = 176.8, b = 70.0, c = 69.8 Å, β = 113.2°. A complete data set was collected to 3.0 Å resolution and structure determination is in progress in order to elucidate the mechanism of PMCA activation by calmodulin

  1. Stability constants important to the understanding of plutonium in environmental waters, hydroxy and carbonate complexation of PuO2+

    International Nuclear Information System (INIS)

    Bennett, D.A.; Lawrence Berkeley Lab., CA

    1990-01-01

    The formation constants for the reactions PuO 2 + + H 2 O = PuO 2 (OH) + H + and PuO 2 + + CO 3 2 = PuO 2 (CO 3 ) - were determined in aqueous sodium perchlorate solutions by laser-induced photoacoustic spectroscopy. The molar absorptivity of the PuO 2 + band at 569 nm decreased with increasing hydroxide concentration. Similarly, spectral changes occurred between 540 and 580 nm as the carbonate concentration was increased. The absorption data were analyzed by the non-linear least-squares program SQUAD to yield complexation constants. Using the specific ion interaction theory, both complexation constants were extrapolated to zero ionic strength. These thermodynamic complexation constants were combined with the oxidation-reduction potentials of Pu to obtain Eh versus pH diagrams. 120 refs., 35 figs., 12 tabs

  2. Advances and Challenges in Computational Plasma Science

    International Nuclear Information System (INIS)

    Tang, W.M.; Chan, V.S.

    2005-01-01

    Scientific simulation, which provides a natural bridge between theory and experiment, is an essential tool for understanding complex plasma behavior. Recent advances in simulations of magnetically-confined plasmas are reviewed in this paper with illustrative examples chosen from associated research areas such as microturbulence, magnetohydrodynamics, and other topics. Progress has been stimulated in particular by the exponential growth of computer speed along with significant improvements in computer technology

  3. Advances and Challenges in Computational Plasma Science

    Energy Technology Data Exchange (ETDEWEB)

    W.M. Tang; V.S. Chan

    2005-01-03

    Scientific simulation, which provides a natural bridge between theory and experiment, is an essential tool for understanding complex plasma behavior. Recent advances in simulations of magnetically-confined plasmas are reviewed in this paper with illustrative examples chosen from associated research areas such as microturbulence, magnetohydrodynamics, and other topics. Progress has been stimulated in particular by the exponential growth of computer speed along with significant improvements in computer technology.

  4. Using a Complexity-Based Perspective to Better Understand the Relationships among Mentoring, School Conflicts, and Novice Retention

    Science.gov (United States)

    Waterman, Sheryn Elaine Spencer

    2011-01-01

    In this study I used complexity-thinking, ecologically-based sustainable capacity-building, narrative methodology, and pragmatism to explore the relationships among mentoring, conflict, and novice retention. In order to explore these relationships, I constructed stories from my interviews with six mentor-novice dyads in a southeastern 9-12 high…

  5. The development of second-order social cognition and its relation with complex language understanding and working memory

    NARCIS (Netherlands)

    Arslan, Burcu; Hohenberger, Annette; Verbrugge, Rineke

    2012-01-01

    In this study, the development of second-order social cognition and its possible relationship with language and memory were investigated. For this reason two second-order false belief tasks (FBT_2), a short term memory task (WST), a complex working memory task (LST), a linguistic perspective-taking

  6. Use of biological priors enhances understanding of genetic architecture and genomic prediction of complex traits within and between dairy cattle breeds

    DEFF Research Database (Denmark)

    Fang, Lingzhao; Sahana, Goutam; Ma, Peipei

    2017-01-01

    sequence variants in Holstein (HOL) and Jersey (JER) cattle were analysed. We first carried out a post-GWAS analysis in a HOL training population to assess the degree of enrichment of the association signals in the gene regions defined by each GO term. We then extended the genomic best linear unbiased......BACKGROUND: A better understanding of the genetic architecture underlying complex traits (e.g., the distribution of causal variants and their effects) may aid in the genomic prediction. Here, we hypothesized that the genomic variants of complex traits might be enriched in a subset of genomic...

  7. Understanding the Complexity of the Lived Experiences of Foundation Degree Sport Lecturers within the Context of Further Education

    Science.gov (United States)

    Aldous, David

    2014-01-01

    This paper provides an ethnographic account of the lived experiences of Further Education (FE) lecturers (N = 4) who are engaged in the transmission of pedagogic knowledge within a Foundation Degree. To further understand the experiences of the lecturers the paper draws upon Stones' quadripartite cycle of structuration. This conceptual and…

  8. Analytical developments for the determination of monomethylmercury complexes with low molecular mass thiols by reverse phase liquid chromatography hyphenated to inductively coupled plasma mass spectrometry.

    Science.gov (United States)

    Bouchet, Sylvain; Björn, Erik

    2014-04-25

    The behavior of monomethylmercury (MMHg) is markedly influenced by its distribution among complexes with low molecular mass (LMM) thiols but analytical methodologies dedicated to measure such complexes are very scarce up to date. In this work, we selected 15 LMM thiols often encountered in living organisms and/or in the environment and evaluated the separation of the 15 corresponding MMHg-thiol complexes by various high performance liquid chromatography (HPLC) columns. Two C18 (Phenomenex Synergi Hydro-RP and LunaC18(2)), two phenyl (Inertsil Ph 3 and 5μm) and one mixed-mode (Restek Ultra IBD) stationary phases were tested for their retention and resolution capacities of the various complexes. The objective was to find simple separation conditions with low organic contents in the mobile phase to provide optimal conditions for detection by inductively coupled plasma mass spectrometry (ICPMS). The 15 complexes were synthesized in solution and characterized by electrospray ionization-mass spectrometry (ESI-MS). The C18 columns tested were either not resolutive enough or too retentive. The 3μm phenyl stationary phase was able to resolve 10 out of the 15 complexes in less than 25min, under isocratic conditions. The mixed-mode column was especially effective at separating the most hydrophilic complexes (6 complexes out of the 15), corresponding to the main LMM thiols found in living organisms. The detection limits (DLs) for these two columns were in the low nanomolar range and overall slightly better for the phenyl column. The possibilities offered by such methodology were exemplified by monitoring the time-course concentrations of four MMHg-thiol complexes within a phytoplankton incubation containing MMHg in the presence of an excess of four added thiols. Copyright © 2014 Elsevier B.V. All rights reserved.

  9. Plasma-surface interactions

    International Nuclear Information System (INIS)

    Goeckner, M J; Nelson, C T; Sant, S P; Jindal, A K; Joseph, E A; Zhou, B S; Padron-Wells, G; Jarvis, B; Pierce, R; Overzet, L J

    2008-01-01

    Materials processing is at a crossroads. Currently a large fraction of industrially viable materials processing is via plasmas. Until recently it has been economical to just examine the influence the plasma properties on the desired surface processes and through this ultimately optimize manufacturing. For example, it is well known that the surface processes (etch or deposition), occur in the top few mono-layers of the surface. Thus, in film growth one requires that molecules from the gas-phase land and bond on the surface. However as processing has reached the nano-scale, development of viable processes has become more and more difficult. In part, this is because of all of the free parameters that exist in plasmas. To overcome this economic issue, tool vendors and semiconductor companies have turned to complex computational models of processing plasmas. For those models to work, one requires a through understanding of all of the gas-phase and surface-phase processes that are exhibited in plasmas. Unfortunately, these processes, particularly those at the surface, are not well understood. In this article we describe a viable model of the surface-phase based on cross sections for processes that occur. While originally developed of fluorocarbon systems, the model also appears to be applicable to hydrocarbon systems.

  10. Using a Virtual Tablet Machine to Improve Student Understanding of the Complex Processes Involved in Tablet Manufacturing.

    Science.gov (United States)

    Mattsson, Sofia; Sjöström, Hans-Erik; Englund, Claire

    2016-06-25

    Objective. To develop and implement a virtual tablet machine simulation to aid distance students' understanding of the processes involved in tablet production. Design. A tablet simulation was created enabling students to study the effects different parameters have on the properties of the tablet. Once results were generated, students interpreted and explained them on the basis of current theory. Assessment. The simulation was evaluated using written questionnaires and focus group interviews. Students appreciated the exercise and considered it to be motivational. Students commented that they found the simulation, together with the online seminar and the writing of the report, was beneficial for their learning process. Conclusion. According to students' perceptions, the use of the tablet simulation contributed to their understanding of the compaction process.

  11. Soluble 1:1 complexes and insoluble 3:2 complexes - Understanding the phase-solubility diagram of hydrocortisone and γ-cyclodextrin.

    Science.gov (United States)

    Schönbeck, Christian; Madsen, Tobias L; Peters, Günther H; Holm, René; Loftsson, Thorsteinn

    2017-10-15

    The molecular mechanisms underlying the drug-solubilizing properties of γ-cyclodextrin were explored using hydrocortisone as a model drug. The B S -type phase-solubility diagram of hydrocortisone with γ-cyclodextrin was thoroughly characterized by measuring the concentrations of hydrocortisone and γ-cyclodextrin in solution and the solid phase. The drug-solubilizer interaction was also studied by isothermal titration calorimetry from which a precise value of the 1:1 binding constant (K 11 =4.01mM -1 at 20°C) was obtained. The formation of water-soluble 1:1 complexes is responsible for the initial increase in hydrocortisone solubility while the precipitation of entities with a 3:2 ratio of γ-cyclodextrin:hydrocortisone is responsible for the plateau and the ensuing strong decrease in solubility once all solid hydrocortisone is used up. The complete phase-solubility diagram is well accounted for by a model employing the 1:1 binding constant and the solubility product of the precipitating 3:2 entity (K 32 S =5.51 mM 5 ). For such systems, a small surplus of γ-cyclodextrin above the optimum concentration may result in a significant decrease in drug solubility, and the implications for drug formulations are briefly discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Enhanced Systemic Understanding of the Information Environment in Complex Crisis Management - Analytical Concept, Version 1.0

    Science.gov (United States)

    2010-10-22

    comprises the dimensions of ‗ media literacy ‘ and ‗intercultural communicative competence‘63. Figure 25: Communicative Competence...competence‘ comprises the dimensions of ‗ media literacy ‘ and ‗intercultural communicative competence‘89. Figure: Communicative Competence ‗ Media literacy ‘ aims...at successfully using media and media-related technology: "We have defined media literacy as: ‗the ability to access, understand and create

  13. EDITORIAL: Plasma jets and plasma bullets Plasma jets and plasma bullets

    Science.gov (United States)

    Kong, M. G.; Ganguly, B. N.; Hicks, R. F.

    2012-06-01

    Plasma plumes, or plasma jets, belong to a large family of gas discharges whereby the discharge plasma is extended beyond the plasma generation region into the surrounding ambience, either by a field (e.g. electromagnetic, convective gas flow, or shock wave) or a gradient of a directionless physical quantity (e.g. particle density, pressure, or temperature). This physical extension of a plasma plume gives rise to a strong interaction with its surrounding environment, and the interaction alters the properties of both the plasma and the environment, often in a nonlinear and dynamic fashion. The plasma is therefore not confined by defined physical walls, thus extending opportunities for material treatment applications as well as bringing in new challenges in science and technology associated with complex open-boundary problems. Some of the most common examples may be found in dense plasmas with very high dissipation of externally supplied energy (e.g. in electrical, optical or thermal forms) and often in or close to thermal equilibrium. For these dense plasmas, their characteristics are determined predominantly by strong physical forces of different fields, such as electrical, magnetic, thermal, shock wave, and their nonlinear interactions [1]. Common to these dense plasma plumes are significant macroscopic plasma movement and considerable decomposition of solid materials (e.g. vaporization). Their applications are numerous and include detection of elemental traces, synthesis of high-temperature materials and welding, laser--plasma interactions, and relativistic jets in particle accelerators and in space [2]-[4]. Scientific challenges in the understanding of plasma jets are exciting and multidisciplinary, involving interweaving transitions of all four states of matter, and their technological applications are wide-ranging and growing rapidly. Using the Web of Science database, a search for journal papers on non-fusion plasma jets reveals that a long initial phase up

  14. Understanding Free Radicals: Isolating Active Thylakoid Membranes and Purifying the Cytochrome b6f Complex for Superoxide Generation Studies

    Directory of Open Access Journals (Sweden)

    Jason Stofleth

    2012-01-01

    Full Text Available All life persists in an environment that is rich in molecular oxygen. The production of oxygen free radicals, or superoxide, is a necessary consequence of the biogenesis of energy in cells. Both mitochondrial and photosynthetic electron transport chains have been found to produce superoxide associated with cell differentiation, proliferation, and cell death, thereby contributing to the effects of aging. Aerobic respiration in mitochondria consumes oxygen, whereas photosynthesis in chloroplasts or cyanobacteria produces oxygen. The increased concentration of molecular oxygen may serve to allow greater availability for the production of superoxide by cytochrome bc complexes in photosynthetic membranes compared to those of mitochondrial membranes. The isolation of well-coupled chloroplasts, containing the cytochrome b6f complex of oxygenic photosynthesis, is a vital initial step in the process of comparing the rate of production of superoxide to those of the homologous cytochrome bc1 complex of aerobic respiration. It is necessary to determine if the isolated chloroplasts have retained their oxygengenerating capability after isolation by an oxygen evolution assay with a Clark-type electrode. A necessary second step, which is the isolation of cytochrome b6f from spinach, has yet to be successfully performed. Oxygen measurements taken from chloroplasts in the presence of the uncoupler, NH4Cl, exhibited a rate of oxygen evolution over three times greater at 344 +/- 18 μmol O2/mg Chlorophyll a/hr than the rate of oxygen evolution without uncoupler at 109 +/- 29 μmol O2/mg Chlorophyll a/hr. These data demonstrate that the technique used to isolate spinach chloroplasts preserves their light-driven electron-transport activity, making them reliable for future superoxide assays.

  15. Regional molecular and cellular differences in the female rabbit Achilles tendon complex: potential implications for understanding responses to loading.

    Science.gov (United States)

    Huisman, Elise S; Andersson, Gustav; Scott, Alexander; Reno, Carol R; Hart, David A; Thornton, Gail M

    2014-05-01

    The aim of this study was: (i) to analyze the morphology and expression of extracellular matrix genes in six different regions of the Achilles tendon complex of intact normal rabbits; and (ii) to assess the effect of ovariohysterectomy (OVH) on the regional expression of these genes. Female New Zealand White rabbits were separated into two groups: (i) intact normal rabbits (n = 4); and (ii) OVH rabbits (n = 8). For each rabbit, the Achilles tendon complex was dissected into six regions: distal gastrocnemius (DG); distal flexor digitorum superficialis; proximal lateral gastrocnemius (PLG); proximal medial gastrocnemius; proximal flexor digitorum superficialis; and paratenon. For each of the regions, hematoxylin and eosin staining was performed for histological evaluation of intact normal rabbit tissues and mRNA levels for proteoglycans, collagens and genes associated with collagen regulation were assessed by real-time reverse transcription-quantitative polymerase chain reaction for both the intact normal and OVH rabbit tissues. The distal regions displayed a more fibrocartilaginous phenotype. For intact normal rabbits, aggrecan mRNA expression was higher in the distal regions of the Achilles tendon complex compared with the proximal regions. Collagen Type I and matrix metalloproteinase-2 expression levels were increased in the PLG compared to the DG in the intact normal rabbit tissues. The tendons from OVH rabbits had lower gene expressions for the proteoglycans aggrecan, biglycan, decorin and versican compared with the intact normal rabbits, although the regional differences of increased aggrecan expression in distal regions compared with proximal regions persisted. The tensile and compressive forces experienced in the examined regions may be related to the regional differences found in gene expression. The lower mRNA expression of the genes examined in the OVH group confirms a potential effect of systemic estrogen on tendon. © 2014 Anatomical Society.

  16. Complex function in the dynamic brain. Comment on “Understanding brain networks and brain organization” by Luiz Pessoa

    Science.gov (United States)

    Anderson, Michael L.

    2014-09-01

    There is much to commend in this excellent overview of the progress we've made toward-and the challenges that remain for-developing an empirical framework for neuroscience that is adequate to the dynamic complexity of the brain [17]. Here I will limit myself first to highlighting the concept of dynamic affiliation, which I take to be the central feature of the functional architecture of the brain, and second to clarifying Pessoa's brief discussion of the ontology of cognition, to be sure readers appreciate this crucial issue.

  17. Klotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depression

    OpenAIRE

    Pavlatou, M G; Remaley, A T; Gold, P W

    2016-01-01

    Klotho is a hormone secreted into human cerebrospinal fluid (CSF), plasma and urine that promotes longevity and influences the onset of several premature senescent phenotypes in mice and humans, including atherosclerosis, cardiovascular disease, stroke and osteoporosis. Preliminary studies also suggest that Klotho possesses tumor suppressor properties. Klotho's roles in these phenomena were first suggested by studies demonstrating that a defect in the Klotho gene in mice results in a signific...

  18. Know Your Client and Know Your Team: A Complexity Inspired Approach to Understanding Safe Transitions in Care

    Directory of Open Access Journals (Sweden)

    Deborah Tregunno

    2013-01-01

    Full Text Available Background. Transitions in care are one of the most important and challenging client safety issues in healthcare. This project was undertaken to gain insight into the practice setting realities for nurses and other health care providers as they manage increasingly complex care transitions across multiple settings. Methods. The Appreciative Inquiry approach was used to guide interviews with sixty-six healthcare providers from a variety of practice settings. Data was collected on participants’ experience of exceptional care transitions and opportunities for improving care transitions. Results. Nurses and other healthcare providers need to know three things to ensure safe care transitions: (1 know your client; (2 know your team on both sides of the transfer; and (3 know the resources your client needs and how to get them. Three themes describe successful care transitions, including flexible structures; independence and teamwork; and client and provider focus. Conclusion. Nurses often operate at the margins of acceptable performance, and flexibility with regulation and standards is often required in complex sociotechnical work like care transitions. Priority needs to be given to creating conditions where nurses and other healthcare providers are free to creatively engage and respond in ways that will optimize safe care transitions.

  19. Avoiding genetic genocide: understanding good intentions and eugenics in the complex dialogue between the medical and disability communities.

    Science.gov (United States)

    Miller, Paul Steven; Levine, Rebecca Leah

    2013-02-01

    The relationship between the medical and disability communities is complex and is influenced by historical, social, and cultural factors. Although clinicians, health-care researchers, and people with disabilities all work from the standpoint of the best interest of disabled individuals, the notion of what actually is "best" is often understood quite differently among these constituencies. Eugenics campaigns, legal restrictions on reproductive and other freedoms, and prenatal testing recommendations predicated on the lesser worth of persons with disabilities have all contributed toward the historic trauma experienced by the disability community, particularly with respect to medical genetics. One premise of personalized medicine is that different individuals require different solutions. Disabled persons' experiences are a reminder that these solutions can be best realized by maintaining awareness and sensitivity in a complex ethical and moral terrain. Geneticists should recognize that their research may have implications for those with disabilities; they should recognize the impact of the historical trauma of the eugenics movement, and seek to involve people with disabilities in discussions about policies that affect them. Dialogue can be messy and uncomfortable, but it is the only way to avoid the mistakes of the past and to ensure a more equitable, and healthful, future.

  20. CO2 conversion by plasma technology: insights from modeling the plasma chemistry and plasma reactor design

    Science.gov (United States)

    Bogaerts, A.; Berthelot, A.; Heijkers, S.; Kolev, St.; Snoeckx, R.; Sun, S.; Trenchev, G.; Van Laer, K.; Wang, W.

    2017-06-01

    In recent years there has been growing interest in the use of plasma technology for CO2 conversion. To improve this application, a good insight into the underlying mechanisms is of great importance. This can be obtained from modeling the detailed plasma chemistry in order to understand the chemical reaction pathways leading to CO2 conversion (either in pure form or mixed with another gas). Moreover, in practice, several plasma reactor types are being investigated for CO2 conversion, so in addition it is essential to be able to model these reactor geometries so that their design can be improved, and the most energy efficient CO2 conversion can be achieved. Modeling the detailed plasma chemistry of CO2 conversion in complex reactors is, however, very time-consuming. This problem can be overcome by using a combination of two different types of model: 0D chemical reaction kinetics models are very suitable for describing the detailed plasma chemistry, while the characteristic features of different reactor geometries can be studied by 2D or 3D fluid models. In the first instance the latter can be developed in argon or helium with a simple chemistry to limit the calculation time; however, the ultimate aim is to implement the more complex CO2 chemistry in these models. In the present paper, examples will be given of both the 0D plasma chemistry models and the 2D and 3D fluid models for the most common plasma reactors used for CO2 conversion in order to emphasize the complementarity of both approaches. Furthermore, based on the modeling insights, the paper discusses the possibilities and limitations of plasma-based CO2 conversion in different types of plasma reactors, as well as what is needed to make further progress in this field.

  1. A model for understanding diagnostic imaging referrals and complex interaction processes within the bigger picture of a healthcare system

    International Nuclear Information System (INIS)

    Makanjee, Chandra R.; Bergh, Anne-Marie; Hoffmann, Willem A.

    2014-01-01

    Using experiences from the South African public healthcare system with limited resources, this review proposes a model that captures a holistic perspective of diagnostic imaging services embedded in a network of negotiated decision-making processes. Professional interdependency and interprofessional collaboration, cooperation and coordination are built around the central notion of integration in order to achieve a seamless transition through the continuum of various types of services needed to come to a diagnosis. Health-system role players interact with patients who enter the system from the perspective of their life-world. The distribution of diagnostic imaging services – within one setting or at multiple levels of care – demonstrates how fragments of information are filtered, interpreted and transformed at each point of care. The proposed model could contribute to alignment towards a common goal: services providing holistic quality of care within and beyond a complex healthcare system

  2. Intermolecular vibrations of the CO2-CS2 complex: Experiment and theory agree, but understanding remains challenging

    Science.gov (United States)

    Dehghany, M.; Rezaei, Mojtaba; Moazzen-Ahmadi, N.; McKellar, A. R. W.; Brown, James; Wang, Xiao-Gang; Carrington, Tucker

    2016-12-01

    The infrared spectrum of the cross-shaped van der Waals complex CO2-CS2 is observed in the region of the CO2 ν3 fundamental band (≈2350 cm-1) using a tuneable diode laser to probe a pulsed supersonic slit jet expansion. Two combination bands are assigned, corresponding to the intermolecular torsion and CO2 bend modes, and their positions and rotational structure agree extremely well (torsional band is well-behaved, but the a-type CO2 bending band is highly unusual, with large shifts between the subband origins for Ka = 0, 2, and 4. The shifts may be rationalized as due to tunnelling effects and Ka-dependent perturbations from other intermolecular modes. But even though they are well predicted by our calculations, there is no simple qualitative explanation. The predicted low-lying planar slipped parallel isomer of CO2-CS2 is not observed.

  3. A preliminary investigation of the applicability of surface complexation modeling to the understanding of transportation cask weeping

    International Nuclear Information System (INIS)

    Granstaff, V.E.; Chambers, W.B.; Doughty, D.H.

    1994-01-01

    A new application for surface complexation modeling is described. These models, which describe chemical equilibria among aqueous and adsorbed species, have typically been used for predicting groundwater transport of contaminants by modeling the natural adsorbents as various metal oxides. Our experiments suggest that this type of modeling can also explain stainless steel surface contamination and decontamination mechanisms. Stainless steel transportation casks, when submerged in a spent fuel storage pool at nuclear power stations, can become contaminated with radionuclides such as 137 Cs, 134 Cs, and 60 Co. Subsequent release or desorption of these contaminants under varying environmental conditions occasionally results in the phenomenon known as open-quotes cask weeping.close quotes We have postulated that contaminants in the storage pool adsorb onto the hydrous metal oxide surface of the passivated stainless steel and are subsequently released (by conversion from a fixed to a removable form) during transportation, due to varying environmental factors, such as humidity, road salt, dirt, and acid rain. It is well known that 304 stainless steel has a chromium enriched passive surface layer; thus its adsorption behavior should be similar to that of a mixed chromium/iron oxide. To help us interpret our studies of reversible binding of dissolved metals on stainless steel surfaces, we have studied the adsorption of Co +2 on Cr 2 O 3 . The data are interpreted using electrostatic surface complexation models. The FITEQL computer program was used to obtain the model binding constants and site densities from the experimental data. The MINTEQA2 computer speciation model was used, with the fitted constants, in an attempt to validate this approach

  4. Plasma Treatments and Biomass Gasification

    Science.gov (United States)

    Luche, J.; Falcoz, Q.; Bastien, T.; Leninger, J. P.; Arabi, K.; Aubry, O.; Khacef, A.; Cormier, J. M.; Lédé, J.

    2012-02-01

    Exploitation of forest resources for energy production includes various methods of biomass processing. Gasification is one of the ways to recover energy from biomass. Syngas produced from biomass can be used to power internal combustion engines or, after purification, to supply fuel cells. Recent studies have shown the potential to improve conventional biomass processing by coupling a plasma reactor to a pyrolysis cyclone reactor. The role of the plasma is twofold: it acts as a purification stage by reducing production of tars and aerosols, and simultaneously produces a rich hydrogen syngas. In a first part of the paper we present results obtained from plasma treatment of pyrolysis oils. The outlet gas composition is given for various types of oils obtained at different experimental conditions with a pyrolysis reactor. Given the complexity of the mixtures from processing of biomass, we present a study with methanol considered as a model molecule. This experimental method allows a first modeling approach based on a combustion kinetic model suitable to validate the coupling of plasma with conventional biomass process. The second part of the paper is summarizing results obtained through a plasma-pyrolysis reactor arrangement. The goal is to show the feasibility of this plasma-pyrolysis coupling and emphasize more fundamental studies to understand the role of the plasma in the biomass treatment processes.

  5. Formation of complexes between hematite nanoparticles and a non-conventional galactomannan gum. Toward a better understanding on interaction processes.

    Science.gov (United States)

    Busch, Verónica M; Loosli, Fréderic; Santagapita, Patricio R; Buera, M Pilar; Stoll, Serge

    2015-11-01

    The physicochemical characteristics of hematite nanoparticles related to their size, surface area and reactivity make them useful for many applications, as well as suitable models to study aggregation kinetics. For several applications (such as remediation of contaminated groundwater) it is crucial to maintain the stability of hematite nanoparticle suspensions in order to assure their arrival to the target place. The use of biopolymers has been proposed as a suitable environmentally friendly option to avoid nanoparticle aggregation and assure their stability. The aim of the present work was to investigate the formation of complexes between hematite nanoparticles and a non-conventional galactomannan (vinal gum--VG) obtained from Prosopis ruscifolia in order to promote hematite nanoparticle coating with a green biopolymer. Zeta potential and size of hematite nanoparticles, VG dispersions and the stability of their mixtures were investigated, as well as the influence of the biopolymer concentration and preparation method. DLS and nanoparticle tracking analysis techniques were used for determining the size and the zeta-potential of the suspensions. VG showed a polydispersed size distribution (300-475 nm Z-average diameter, 0.65 Pdi) and a negative zeta potential (between -1 and -12 mV for pH2 and 12, respectively). The aggregation of hematite nanoparticles (3.3 mg/L) was induced by the addition of VG at lower concentrations than 2mg/L (pH5.5). On the other hand, hematite nanoparticles were stabilized at concentrations of VG higher than 2 mg/L. Several phenomena between hematite nanoparticles and VG were involved: steric effects, electrostatic interactions, charge neutralization, charge inversion and polymer bridging. The process of complexation between hematite nanoparticles and the biopolymer was strongly influenced by the preparation protocols. It was concluded that the aggregation, dispersion, and stability of hematite nanoparticles depended on biopolymer

  6. Associations between speech understanding and auditory and visual tests of verbal working memory: Effects of linguistic complexity, task, age and hearing loss

    Directory of Open Access Journals (Sweden)

    Sherri L. Smith

    2015-09-01

    Full Text Available Listeners with hearing loss commonly report having difficulty understanding speech, particularly in noisy environments. Their difficulties could be due to auditory and cognitive processing problems. Performance on speech-in-noise tests has been correlated with reading working memory span (RWMS, a measure often chosen to avoid the effects of hearing loss. If the goal is to assess the cognitive consequences of listeners’ auditory processing abilities, however, then listening working memory span (LWMS could be a more informative measure. Some studies have examined the effects of different degrees and types of masking on working memory, but less is known about the demands placed on working memory depending on the linguistic complexity of the target speech or the task used to measure speech understanding in listeners with hearing loss. Compared to RWMS, LWMS measures using different speech targets and maskers may provide a more ecologically valid approach. To examine the contributions of RWMS and LWMS to speech understanding, we administered two working memory measures (a traditional RWMS measure and a new LWMS measure, and a battery of tests varying in the linguistic complexity of the speech materials, the presence of babble masking, and the task. Participants were a group of younger listeners with normal hearing and two groups of older listeners with hearing loss (n = 24 per group. There was a significant group difference and a wider range in performance on LWMS than on RWMS. There was a significant correlation between both working memory measures only for the oldest listeners with hearing loss. Notably, there were only few significant correlations among the working memory and speech understanding measures. These findings suggest that working memory measures reflect individual differences that are distinct from those tapped by these measures of speech understanding.

  7. Associations between speech understanding and auditory and visual tests of verbal working memory: effects of linguistic complexity, task, age, and hearing loss.

    Science.gov (United States)

    Smith, Sherri L; Pichora-Fuller, M Kathleen

    2015-01-01

    Listeners with hearing loss commonly report having difficulty understanding speech, particularly in noisy environments. Their difficulties could be due to auditory and cognitive processing problems. Performance on speech-in-noise tests has been correlated with reading working memory span (RWMS), a measure often chosen to avoid the effects of hearing loss. If the goal is to assess the cognitive consequences of listeners' auditory processing abilities, however, then listening working memory span (LWMS) could be a more informative measure. Some studies have examined the effects of different degrees and types of masking on working memory, but less is known about the demands placed on working memory depending on the linguistic complexity of the target speech or the task used to measure speech understanding in listeners with hearing loss. Compared to RWMS, LWMS measures using different speech targets and maskers may provide a more ecologically valid approach. To examine the contributions of RWMS and LWMS to speech understanding, we administered two working memory measures (a traditional RWMS measure and a new LWMS measure), and a battery of tests varying in the linguistic complexity of the speech materials, the presence of babble masking, and the task. Participants were a group of younger listeners with normal hearing and two groups of older listeners with hearing loss (n = 24 per group). There was a significant group difference and a wider range in performance on LWMS than on RWMS. There was a significant correlation between both working memory measures only for the oldest listeners with hearing loss. Notably, there were only few significant correlations among the working memory and speech understanding measures. These findings suggest that working memory measures reflect individual differences that are distinct from those tapped by these measures of speech understanding.

  8. Associations between speech understanding and auditory and visual tests of verbal working memory: effects of linguistic complexity, task, age, and hearing loss

    Science.gov (United States)

    Smith, Sherri L.; Pichora-Fuller, M. Kathleen

    2015-01-01

    Listeners with hearing loss commonly report having difficulty understanding speech, particularly in noisy environments. Their difficulties could be due to auditory and cognitive processing problems. Performance on speech-in-noise tests has been correlated with reading working memory span (RWMS), a measure often chosen to avoid the effects of hearing loss. If the goal is to assess the cognitive consequences of listeners’ auditory processing abilities, however, then listening working memory span (LWMS) could be a more informative measure. Some studies have examined the effects of different degrees and types of masking on working memory, but less is known about the demands placed on working memory depending on the linguistic complexity of the target speech or the task used to measure speech understanding in listeners with hearing loss. Compared to RWMS, LWMS measures using different speech targets and maskers may provide a more ecologically valid approach. To examine the contributions of RWMS and LWMS to speech understanding, we administered two working memory measures (a traditional RWMS measure and a new LWMS measure), and a battery of tests varying in the linguistic complexity of the speech materials, the presence of babble masking, and the task. Participants were a group of younger listeners with normal hearing and two groups of older listeners with hearing loss (n = 24 per group). There was a significant group difference and a wider range in performance on LWMS than on RWMS. There was a significant correlation between both working memory measures only for the oldest listeners with hearing loss. Notably, there were only few significant correlations among the working memory and speech understanding measures. These findings suggest that working memory measures reflect individual differences that are distinct from those tapped by these measures of speech understanding. PMID:26441769

  9. Developing Seventh Grade Students' Understanding of Complex Environmental Problems with Systems Tools and Representations: a Quasi-experimental Study

    Science.gov (United States)

    Doganca Kucuk, Zerrin; Saysel, Ali Kerem

    2017-03-01

    A systems-based classroom intervention on environmental education was designed for seventh grade students; the results were evaluated to see its impact on the development of systems thinking skills and standard science achievement and whether the systems approach is a more effective way to teach environmental issues that are dynamic and complex. A quasi-experimental methodology was used to compare performances of the participants in various dimensions, including systems thinking skills, competence in dynamic environmental problem solving and success in science achievement tests. The same pre-, post- and delayed tests were used with both the comparison and experimental groups in the same public middle school in Istanbul. Classroom activities designed for the comparison group (N = 20) followed the directives of the Science and Technology Curriculum, while the experimental group (N = 22) covered the same subject matter through activities benefiting from systems tools and representations such as behaviour over time graphs, causal loop diagrams, stock-flow structures and hands-on dynamic modelling. After a one-month systems-based instruction, the experimental group demonstrated significantly better systems thinking and dynamic environmental problem solving skills. Achievement in dynamic problem solving was found to be relatively stable over time. However, standard science achievement did not improve at all. This paper focuses on the quantitative analysis of the results, the weaknesses of the curriculum and educational implications.

  10. The Climate Change-Road Safety-Economy Nexus: A System Dynamics Approach to Understanding Complex Interdependencies

    Directory of Open Access Journals (Sweden)

    Mehdi Alirezaei

    2017-01-01

    Full Text Available Road accidents have the highest externality costs to society and to the economy, even when compared to the externality damages associated with air emissions and oil dependency. Road safety is one of the most complicated topics, which involves many interdependencies, and so, a sufficiently thorough analysis of roadway safety will require a novel system-based approach in which the associated feedback relationships and causal effects are given appropriate consideration. The factors affecting accident frequency and severity are highly dependent on economic parameters, environmental factors and weather conditions. In this study, we try to use a system dynamics modeling approach to model the climate change-road safety-economy nexus, thereby investigating the complex interactions among these important areas by tracking how they affect each other over time. For this purpose, five sub-models are developed to model each aspect of the overall nexus and to interact with each other to simulate the overall system. As a result, this comprehensive model can provide a platform for policy makers to test the effectiveness of different policy scenarios to reduce the negative consequences of traffic accidents and improve road safety.

  11. Understanding the complex determinants of height and adiposity in disadvantaged daycare preschoolers in Salvador, NE Brazil through structural equation modelling.

    Science.gov (United States)

    Lander, Rebecca L; Williams, Sheila M; Costa-Ribeiro, Hugo; Mattos, Angela P; Barreto, Danile L; Houghton, Lisa A; Bailey, Karl B; Lander, Alastair G; Gibson, Rosalind S

    2015-10-23

    Earlier we reported on growth and adiposity in a cross-sectional study of disadvantaged Brazilian preschoolers. Here we extend the work on these children, using structural equation modelling (SEM) to gather information on the complex relationships between the variables influencing height and adiposity. We hope this information will help improve the design and effectiveness of future interventions for preschoolers. In 376 preschoolers aged 3-6 years attending seven philanthropic daycares in Salvador, we used SEM to examine direct and indirect relationships among biological (sex, ethnicity, birth order, maternal height and weight), socio-economic, micronutrient (haemoglobin, serum selenium and zinc), and environmental (helminths, de-worming) variables on height and adiposity, as reflected by Z-scores for height-for-age (HAZ) and body mass index (BMIZ). Of the children, 11 % had HAZ  1. Of their mothers, 8 % had short stature, and 50 % were overweight or obese. Based on standardized regression coefficients, significant direct effects (p children.

  12. Understanding pulp delignification by laccase-mediator systems through isolation and characterization of lignin-carbohydrate complexes.

    Science.gov (United States)

    Du, Xueyu; Li, Jiebing; Gellerstedt, Göran; Rencoret, Jorge; Del Río, José C; Martínez, Angel T; Gutiérrez, Ana

    2013-09-09

    The effects and mechanism of pulp delignification by laccases in the presence of redox mediators have been investigated on unbleached eucalyptus kraft pulp treated with laccases from Pycnoporus cinnabarinus (PcL) and Myceliophthora thermophila (MtL) and 1-hydroxybenzotriazole (HBT) and methyl syringate (MeS) as mediators, respectively. Determination of the corrected κ number in eucalyptus pulps after the enzymatic treatments revealed that the PcL-HBT system exhibited a more remarkable delignification effect than the MtL-MeS system. To obtain further insight, lignin-carbohydrate complexes were fractionated and subsequently characterized by nuclear magnetic resonance, thioacidolysis (followed by gas chromatography and size exclusion chromatography), and pyrolysis-gas chromatography-mass spectrometry (pyrolysis-GC-MS) analyses before and after the enzymatic treatments and their controls. We can conclude that the laccase-mediator treatments altered the lignin structures in such a way that more lignin was recovered in the xylan-lignin fractions, as shown by Klason lignin estimation, with smaller amounts of both syringyl (S) and guaiacyl (G) uncondensed units, as shown by thioacidolysis and gas chromatography, especially after the PcL-HBT treatment. The laccase-mediator treatment produced oxidation at Cα and cleavage of Cα and Cβ bonds in pulp lignin, as shown by pyrolysis-GC-MS. The general mechanism of residual lignin degradation in the pulp by laccase-mediator treatments is discussed in light of the results obtained.

  13. Dynamin-like protein 1 at the Golgi complex: A novel component of the sorting/targeting machinery en route to the plasma membrane

    Energy Technology Data Exchange (ETDEWEB)

    Bonekamp, Nina A. [Centre for Cell Biology and Department of Biology, University of Aveiro, Campus Universitario de Santiago, 3810-193 Aveiro (Portugal); Vormund, Kerstin; Jacob, Ralf [Department of Cell Biology and Cell Pathology, University of Marburg, Robert-Koch-Str. 6, 35037 Marburg (Germany); Schrader, Michael, E-mail: mschrader@ua.pt [Centre for Cell Biology and Department of Biology, University of Aveiro, Campus Universitario de Santiago, 3810-193 Aveiro (Portugal)

    2010-12-10

    The final step in the liberation of secretory vesicles from the trans-Golgi network (TGN) involves the mechanical action of the large GTPase dynamin as well as conserved dynamin-independent fission mechanisms, e.g. mediated by Brefeldin A-dependent ADP-ribosylated substrate (BARS). Another member of the dynamin family is the mammalian dynamin-like protein 1 (DLP1/Drp1) that is known to constrict and tubulate membranes, and to divide mitochondria and peroxisomes. Here, we examined a potential role for DLP1 at the Golgi complex. DLP1 localized to the Golgi complex in some but not all cell lines tested, thus explaining controversial reports on its cellular distribution. After silencing of DLP1, an accumulation of the apical reporter protein YFP-GL-GPI, but not the basolateral reporter VSVG-SP-GFP at the Golgi complex was observed. A reduction in the transport of YFP-GL-GPI to the plasma membrane was confirmed by surface immunoprecipitation and TGN-exit assays. In contrast, YFP-GL-GPI trafficking was not disturbed in cells silenced for BARS, which is involved in basolateral sorting and trafficking of VSVG-SP-GFP in COS-7 cells. Our data indicate a new role for DLP1 at the Golgi complex and thus a role for DLP1 as a novel component of the apical sorting machinery at the TGN is discussed.

  14. Dynamin-like protein 1 at the Golgi complex: A novel component of the sorting/targeting machinery en route to the plasma membrane

    International Nuclear Information System (INIS)

    Bonekamp, Nina A.; Vormund, Kerstin; Jacob, Ralf; Schrader, Michael

    2010-01-01

    The final step in the liberation of secretory vesicles from the trans-Golgi network (TGN) involves the mechanical action of the large GTPase dynamin as well as conserved dynamin-independent fission mechanisms, e.g. mediated by Brefeldin A-dependent ADP-ribosylated substrate (BARS). Another member of the dynamin family is the mammalian dynamin-like protein 1 (DLP1/Drp1) that is known to constrict and tubulate membranes, and to divide mitochondria and peroxisomes. Here, we examined a potential role for DLP1 at the Golgi complex. DLP1 localized to the Golgi complex in some but not all cell lines tested, thus explaining controversial reports on its cellular distribution. After silencing of DLP1, an accumulation of the apical reporter protein YFP-GL-GPI, but not the basolateral reporter VSVG-SP-GFP at the Golgi complex was observed. A reduction in the transport of YFP-GL-GPI to the plasma membrane was confirmed by surface immunoprecipitation and TGN-exit assays. In contrast, YFP-GL-GPI trafficking was not disturbed in cells silenced for BARS, which is involved in basolateral sorting and trafficking of VSVG-SP-GFP in COS-7 cells. Our data indicate a new role for DLP1 at the Golgi complex and thus a role for DLP1 as a novel component of the apical sorting machinery at the TGN is discussed.

  15. Understanding reflection behavior as a key for interpreting complex signals in FBRM monitoring of microparticle preparation processes.

    Science.gov (United States)

    Vay, Kerstin; Friess, Wolfgang; Scheler, Stefan

    2012-11-01

    The application of focused beam reflectance measurement (FBRM) was studied in a larger scale PLGA microparticle preparation process for monitoring changes of the particle size and the particles' surface properties. Further understanding how these parameters determine the chord length distribution (CLD) was gained by means of single object measurements and data of monodisperse microparticles. It was evaluated how the FBRM signal is influenced by the surface characteristics of the tested materials and the measuring conditions. Particles with good scattering properties provided comparable values for the CLD and the particle size distribution. Translucent particles caused an overestimation of the particle size by FBRM, whereas the values for transparent emulsion droplets were too low. Despite a strong dependence of FBRM results on the optical properties of the samples, it is a beneficial technique for online monitoring of microparticle preparation processes. The study demonstrated how changing reflection properties can be used to monitor structural changes during the solidification of emulsion droplets and to detect process instabilities by FBRM. Copyright © 2012 Elsevier B.V. All rights reserved.

  16. Superconducting plasmas

    International Nuclear Information System (INIS)

    Ohnuma, Toshiro; Ohno, J.

    1994-01-01

    Superconducting (SC) plasmas are proposed and investigated. The SC plasmas are not yet familiar and have not yet been studied. However, the existence and the importance of SC plasmas are stressed in this report. The existence of SC plasmas are found as follows. There is a fundamental property of Meissner effect in superconductors, which shows a repulsive effect of magnetic fields. Even in that case, in a microscopic view, there is a region of magnetic penetration. The penetration length λ is well-known as London's penetration depth, which is expressed as δ = (m s /μ 0 n s q s 2 ) 1/2 where m s , n s , q s and μ o show the mass, the density, the charge of SC electron and the permeability in free space, respectively. Because this expression is very simple, no one had tried it into more simple and meaningful form. Recently, one of the authors (T.O.) has found that the length can be expressed into more simple and understandable fundamental form as λ = c/ω ps where c = (ε 0 μ 0 ) -1/2 and ω ps = (n s q s 2 /m s ε 0 ) 1/2 are the light velocity and the superconducting plasma frequency. From this simple expression, the penetration depth of the magnetic field to SC is found as a SC plasma skin depth, that is, the fundamental property of SC can be expressed by the SC plasmas. This discovery indicates an importance of the studies of superconducting plasmas. From these points, several properties (propagating modes et al) of SC plasmas, which consist of SC electrons, normal electrons and lattice ions, are investigated in this report. Observations of SC plasma frequency is also reported with a use of Terahertz electromagnet-optical waves

  17. Toward an analytical framework for understanding complex social-ecological systems when conducting environmental impact assessments in South Africa

    Directory of Open Access Journals (Sweden)

    Rebecca Bowd

    2015-03-01

    counterpoint to established approaches and could contribute to improving the quality of EIAs with respect to the complex SESs that characterize the developing world.

  18. Resistance Switching in Complex Oxides: Improvements in Understanding and Function for Use as Non-Volatile Memory

    Science.gov (United States)

    Young, Kristina Garrison

    2011-12-01

    Pro0.7Ca0.3MnO3 (PCMO) is a complex oxide that is studied for use as a non-volatile memory with potential to replace flash-type memory. PCMO functions as a resistive random access memory (RRAM) whose memory function is due to an oxygen vacancy concentration change that occurs in the top interface of the PCMO during the application of an electric field. The concentration of the oxygen ions/vacancies in this top interface region significantly affects the resistance seen in a simple thin film device. The electric field required to move ions/vacancies within PCMO is generated by a short (ns), low voltage (few V) pulse. During the pulse a high current is seen that is not commensurate with the resistance seen after the removal of the pulse. Additionally, after the removal of the pulse there is a degradation of the resistance state set by the pulse. The high current seen during the pulse has been explored using electrical characterization techniques and is believed to be due to quantum mechanical tunneling through the high resistance interface region. Modeling of conduction values confirms that quantum mechanical tunneling is the source of the high current. The degradation of the state after the removal of the pulse has been improved through the nanostructure modification of the PCMO film. A thin (barrier layer was placed immediately below the interface of the PCMO minimizing the back diffusion of ions/vacancies after removal of the pulse. The modification improved the EPIR ratio, fatigue and retention in PCMO.

  19. Plasma metallization

    International Nuclear Information System (INIS)

    Crowther, J.M.

    1997-09-01

    Many methods are currently used for the production of thin metal films. However, all of these have drawbacks associated with them, for example the need for UHV conditions, high temperatures, exotic metal precursors, or the inability to coat complex shaped objects. Reduction of supported metal salts by non-isothermal plasma treatment does not suffer from these drawbacks. In order to produce and analyse metal films before they become contaminated, a plasma chamber which could be attached directly to a UHV chamber with XPS capability was designed and built. This allowed plasma treatment of supported metal salts and surface analysis by XPS to be performed without exposure of the metal film to the atmosphere. Non-equilibrium plasma treatment of Nylon 66 supported gold(lll) chloride using hydrogen as the feed gas resulted in a 95% pure gold film, the remaining 5% of the film being carbon. If argon or helium were used as the feed gases during plasma treatment the resultant gold films were 100% pure. Some degree of surface contamination of the films due to plasma treatment was observed but was easily removed by argon ion cleaning. Hydrogen plasma reduction of glass supported silver(l) nitrate and palladium(ll) acetate films reveals that this metallization technique is applicable to a wide variety of metal salts and supports, and has also shown the ability of plasma reduction to retain the complex 'fern-like' structures seen for spin coated silver(l) nitrate layers. Some metal salts are susceptible to decomposition by X-rays. The reduction of Nylon 66 supported gold(lll) chloride films by soft X-rays to produce nanoscopic gold particles has been studied. The spontaneous reduction of these X-ray irradiated support gold(lll) chloride films on exposure to the atmosphere to produce gold rich metallic films has also been reported. (author)

  20. Hypoxia monitoring activities within the FP7 EU-project HYPOX: diverse approaches to understand a complex phenomenon

    Science.gov (United States)

    Janssen, F.; Waldmann, C.; Boetius, A.

    2012-04-01

    Hypoxic conditions in aquatic systems and the occurrence of 'dead zones' increase worldwide due to man-made eutrophication and global warming with consequences for biodiversity, ecosystem functions and services such as fisheries, aquaculture and tourism. Monitoring of hypoxia and its consequences has to (1) account for the appropriate temporal and spatial scales, (2) separate anthropogenic from natural drivers and long-term trends from natural variations, (3) assess ecosystem response, (4) use modeling tools for generalization and prediction, and (5) share data and obtained knowledge. In 2009 the EU FP7 project HYPOX (www.hypox.net) started out as a pioneering attempt to improve and integrate hypoxia observation capacities addressing these requirements. Target ecosystems selected for HYPOX cover a broad range of settings (e.g., hydrography, oxygenation status, biological activity, anthropogenic impact) and differ in their sensitivity towards change. Semi-enclosed basins with permanent anoxia (Black Sea, Baltic Sea), are included as well as seasonally or locally hypoxic land-locked systems (fjords, lagoons, lakes) and open ocean systems with high sensitivity to global warming (North Atlantic - Arctic transition). Adopted monitoring approaches involve autonomous, cabled, and shipboard instruments and include static and profiling moorings, benthic observatories, drifters, as well as classical CTD surveys. In order to improve observatory performance, project activities encompass developments of oxygen sensors as well as calibration procedures and technologies to reduce biofouling. Modeling and data assimilation are used to synthesize findings, to obtain an in-depth understanding of hypoxia causes and consequences, and to improve forecasting capacities. For integration of the collected information into a global oxygen observing system, results are disseminated through the HYPOX portal following GEOSS data sharing principles. This presentation will give an overview of

  1. Understanding the addiction cycle: a complex biology with distinct contributions of genotype vs. sex at each stage.

    Science.gov (United States)

    Wilhelm, C J; Hashimoto, J G; Roberts, M L; Sonmez, M K; Wiren, K M

    2014-10-24

    Ethanol abuse can lead to addiction, brain damage and premature death. The cycle of alcohol addiction has been described as a composite consisting of three stages: intoxication, withdrawal and craving/abstinence. There is evidence for contributions of both genotype and sex to alcoholism, but an understanding of the biological underpinnings is limited. Utilizing both sexes of genetic animal models with highly divergent alcohol withdrawal severity, Withdrawal Seizure-Resistant (WSR) and Withdrawal Seizure-Prone (WSP) mice, the distinct contributions of genotype/phenotype and of sex during addiction stages on neuroadaptation were characterized. Transcriptional profiling was performed to identify expression changes as a consequence of chronic intoxication in the medial prefrontal cortex. Significant expression differences were identified on a single platform and tracked over a behaviorally relevant time course that covered each stage of alcohol addiction; i.e., after chronic intoxication, during peak withdrawal, and after a defined period of abstinence. Females were more sensitive to ethanol with higher fold expression differences. Bioinformatics showed a strong effect of sex on the data structure of expression profiles during chronic intoxication and at peak withdrawal irrespective of genetic background. However, during abstinence, differences were observed instead between the lines/phenotypes irrespective of sex. Confirmation of identified pathways showed distinct inflammatory signaling following intoxication at peak withdrawal, with a pro-inflammatory phenotype in females but overall suppression of immune signaling in males. Combined, these results suggest that each stage of the addiction cycle is influenced differentially by sex vs. genetic background and support the development of stage- and sex-specific therapies for alcohol withdrawal and the maintenance of sobriety. Published by Elsevier Ltd.

  2. Understanding complex exposure history of Mount Hampton, West Antarctica using cosmogenic 3He, 21Ne and 10Be in olivine

    Science.gov (United States)

    Carracedo, Ana; Rodes, Angel; Stuart, Finlay; Smellie, John

    2016-04-01

    Combining stable and radioactive cosmogenic nuclides is an established tool for revealing the complexities of long-term landscape development. To date most studies have concentrated on 21Ne and 10Be in quartz. We have combined different chemical protocols for extraction of cosmogenic 10Be from olivine, and measured concentrations in olivine from lherzolite xenoliths from the peak of Mount Hampton (~3,200 m), an 11 Ma shield volcano on the West Antarctic rift flank. We combine this data with cosmogenic 3He (and 21Ne) in the olivines in order to unravel the long-term environmental history of the region. The mean 3He/21Ne ratio (1.98 ± 0.22) is consistent with the theoretical value and previous determinations. 10Be/3He ratios (0.012 to 0.018) are significantly lower than the instantaneous production ratio (~0.045). The data are consistent with 1-3 Ma of burial. The altitude of the volcano rules out over-topping of the peak by the West Antarctic Ice Sheet only possible burial could be generated by the growth of an ice cap although this contradicts the absence of evidence for ice cover. The 3He-10Be data can also be generated during episodic erosion of the volcanic ash over the last few million years. The data requires a minimum depth of 1 to 2.5 m for the samples during a minimum age of 5 Ma and maximum long-term erosion rate of ~0.5 m/Ma with at least one erosive episode reflecting short-term erosion rate of ~7 m/Ma that would have brought the samples into the surface during the last ~350 ka. Erosion in this type of landscape could be related to interglacial periods where cryostatic erosion can occur generating an increase in the erosion rate. This study shows that episodic erosion can produce stable-radioactive cosmogenic isotope systematics that are similar to those generated by exposure-burial cycles.

  3. Complexity explained

    CERN Document Server

    Erdi, Peter

    2008-01-01

    This book explains why complex systems research is important in understanding the structure, function and dynamics of complex natural and social phenomena. Readers will learn the basic concepts and methods of complex system research.

  4. The Holocene history of the North American Monsoon: 'known knowns' and 'known unknowns' in understanding its spatial and temporal complexity

    Science.gov (United States)

    Metcalfe, Sarah E.; Barron, John A.; Davies, Sarah J.

    2015-01-01

    Evidence for climatic change across the North American Monsoon (NAM) and adjacent areas is reviewed, drawing on continental and marine records and the application of climate models. Patterns of change at 12,000, 9000, 6000 and 4000 cal yr BP are presented to capture the nature of change from the Younger Dryas (YD) and through the mid-Holocene. At the YD, conditions were cooler overall, wetter in the north and drier in the south, while moving into the Holocene wetter conditions became established in the south and then spread north as the NAM strengthened. Until c. 8000 cal yr BP, the Laurentide Ice Sheet influenced precipitation in the north by pushing the Bermuda High further south. The peak extent of the NAM seems to have occurred around 6000 cal yr BP. 4000 cal yr BP marks the start of important changes across the NAM region, with drying in the north and the establishment of the clear differences between the summer-rain dominated south and central areas and the north, where winter rain is more important. This differentiation between south and north is crucial to understanding many climate responses across the NAM. This increasing variability is coincident with the declining influence of orbital forcing. 4000 cal yr BP also marks the onset of significant anthropogenic activity in many areas. For the last 2000 years, the focus is on higher temporal resolution change, with strong variations across the region. The Medieval Climate Anomaly (MCA) is characterised by centennial scale ‘megadrought’ across the southwest USA, associated with cooler tropical Pacific SSTs and persistent La Niña type conditions. Proxy data from southern Mexico, Central America and the Caribbean reveal generally wetter conditions, whereas records from the highlands of central Mexico and much of the Yucatan are typified by long -term drought. The Little Ice Age (LIA), in the north, was characterised by cooler, wetter winter conditions that have been linked with increased

  5. Stimulation of Slack K+ Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex

    Directory of Open Access Journals (Sweden)

    Matthew R. Fleming

    2016-08-01

    Full Text Available Human mutations in the cytoplasmic C-terminal domain of Slack sodium-activated potassium (KNa channels result in childhood epilepsy with severe intellectual disability. Slack currents can be increased by pharmacological activators or by phosphorylation of a Slack C-terminal residue by protein kinase C. Using an optical biosensor assay, we find that Slack channel stimulation in neurons or transfected cells produces loss of mass near the plasma membrane. Slack mutants associated with intellectual disability fail to trigger any change in mass. The loss of mass results from the dissociation of the protein phosphatase 1 (PP1 targeting protein, Phactr-1, from the channel. Phactr1 dissociation is specific to wild-type Slack channels and is not observed when related potassium channels are stimulated. Our findings suggest that Slack channels are coupled to cytoplasmic signaling pathways and that dysregulation of this coupling may trigger the aberrant intellectual development associated with specific childhood epilepsies.

  6. Insight to structural subsite recognition in plant thiol protease-inhibitor complexes : Understanding the basis of differential inhibition and the role of water

    Directory of Open Access Journals (Sweden)

    Mukhopadhayay Bishnu P

    2001-09-01

    Full Text Available Abstract Background This work represents an extensive MD simulation / water-dynamics studies on a series of complexes of inhibitors (leupeptin, E-64, E-64-C, ZPACK and plant cysteine proteases (actinidin, caricain, chymopapain, calotropin DI of papain family to understand the various interactions, water binding mode, factors influencing it and the structural basis of differential inhibition. Results The tertiary structure of the enzyme-inhibitor complexes were built by visual interactive modeling and energy minimization followed by dynamic simulation of 120 ps in water environment. DASA study with and without the inhibitor revealed the potential subsite residues involved in inhibition. Though the interaction involving main chain atoms are similar, critical inspection of the complexes reveal significant differences in the side chain interactions in S2-P2 and S3-P3 pairs due to sequence differences in the equivalent positions of respective subsites leading to differential inhibition. Conclusion The key finding of the study is a conserved site of a water molecule near oxyanion hole of the enzyme active site, which is found in all the modeled complexes and in most crystal structures of papain family either native or complexed. Conserved water molecules at the ligand binding sites of these homologous proteins suggest the structural importance of the water, which changes the conventional definition of chemical geometry of inhibitor binding domain, its shape and complimentarity. The water mediated recognition of inhibitor to enzyme subsites (Pn...H2O....Sn of leupeptin acetyl oxygen to caricain, chymopapain and calotropinDI is an additional information and offer valuable insight to potent inhibitor design.

  7. Nonlinear dynamics and plasma transport

    Energy Technology Data Exchange (ETDEWEB)

    Antonsen, T.M. Jr.; Drake, J.F.; Finn, J.M.; Guzdar, P.N.; Hassam, A.B.; Sageev, R.Z.

    1993-01-01

    This progress report details work done on a program in nonlinear dynamical aspects of plasma turbulence and transport funded by DOE since 1989. This program has been in cooperation with laboratories in theUSSR [now Russia and the Confederation of Independent States (CIS)]. The purpose of this program has been: To promote the utilization of recent pathbreaking developments in nonlinear science in plasma turbulence and transport. To promote cooperative scientific investigations between the US and CIS in the related areas of nonlinear science and plasma turbulence and transport. In the work reported in our progress report, we have studied simple models which are motivated by observation on actual fusion devices. The models focus on the important physical processes without incorporating the complexity of the geometry of real devices. This allows for a deeper analysis and understanding of the system both analytically and numerically.

  8. Surface modification of coronary artery stent by Ti-O/Ti-N complex film coating prepared with plasma immersion ion implantation and deposition

    International Nuclear Information System (INIS)

    Huang, N.; Leng, Y.X.; Yang, P.

    2006-01-01

    This paper reported the work of surface coating of Ti-O/Ti-N complex films on coronary stents by means of the plasma immersion ion implantation/deposition process. The deformation behavior of the Ti-O/Ti-N coated stainless steel stents was investigated. In vivo investigation of the anticoagulation behavior of Ti-O coated coronary stents was also performed. The results of mechanical characterization of the Ti-O/Ti-N coated stents show that the film has strong binding strength, and to some extent the ability to withstand plastic deformation. The biological response behavior of the coated stent surface was significantly different from the uncoated. The results of implantation of stents into rabbit ventral aorta show no thrombus formation on the surfaces of the Ti-O coated stents, although serious coagulation had occurred on the surfaces of unmodified stents over a period of 4 weeks under conditions with no anticoagulant

  9. ''Dusty plasmas''

    International Nuclear Information System (INIS)

    Tsytovich, V.N.; Bingham, R.; Angelis, U. de

    1989-09-01

    The field of ''dusty plasmas'' promises to be a very rewarding topic of research for the next decade or so, not only from the academic point of view where the emphasis is on developing the theory of the often complex collective and non-linear processes, but also from the point of view of applications in astrophysics, space physics, environmental and energy research. In this ''comment'' we should like to sketch the current development of this fast growing and potentially very important research area. We will discuss the new features of ''dusty'' plasmas in the most general terms and then briefly mention some successful applications and effects which have already been examined. (author)

  10. Étude des techniques de spectrométrie de plasma pour l'analyse de matériaux à spectres optiques complexes : application aux terres rares et aux matériaux plastiques

    OpenAIRE

    Barbier, Sophie

    2014-01-01

    The LIBS (Laser Induced Breakdown Spectroscopy) technique is an elemental analysis technique based on the use of the optical emission spectrum from a sample of laser ablation. Today, LIBS has not emerged as a technique of choice for the majority of applications, as is the case for inductive coupled plasma techniques. One of the main reasons for this is the difficulty in providing accurate quantitative measurements. So there is now a need to better understand and characterize plasmas and pheno...

  11. Reviews of plasma physics

    CERN Document Server

    2008-01-01

    "Reviews of Plasma Physics Volume 24," edited by V.D. Shafranov, presents two reviews from the cutting-edge of Russian plasma physics research. The first review by V.A. Rozhansky devoted to the mechanisms of transverse conductivity and generation of self-consistent electric fields in strongly ionized magnetized plasma. The second review by O.G. Bakunin considers numerous aspects of turbulent transport in plasma and fluids. This review is focused on scaling arguments for describing anomalous diffusion in the presence of complex structures. These topics are especially important for fusion plasma research, plasma astrophysics, discharge physics, and turbulence

  12. GEM Plate Boundary Simulations for the Plate Boundary Observatory: A Program for Understanding the Physics of Earthquakes on Complex Fault Networks via Observations, Theory and Numerical Simulation

    Science.gov (United States)

    Rundle, J. B.; Rundle, P. B.; Klein, W.; de sa Martins, J.; Tiampo, K. F.; Donnellan, A.; Kellogg, L. H.

    The last five years have seen unprecedented growth in the amount and quality of geodetic data collected to characterize crustal deformation in earthquake-prone areas such as California and Japan. The installation of the Southern California Integrated Geodetic Network (SCIGN) and the Bay Area Regional Deformation (BARD) network are two examples. As part of the recently proposed Earthscope NSF/GEO/EAR/MRE initiative, the Plate Boundary Observatory (PBO) plans to place more than a thousand GPS, strainmeters, and deformation sensors along the active plate boundary of the western coast of the United States, Mexico and Canada (http://www.earthscope.org/pbo.com.html). The scientific goals of PBO include understanding how tectonic plates interact, together with an emphasis on understanding the physics of earthquakes. However, the problem of understanding the physics of earthquakes on complex fault networks through observations alone is complicated by our inability to study the problem in a manner familiar to laboratory scientists, by means of controlled, fully reproducible experiments. We have therefore been motivated to construct a numerical simulation technology that will allow us to study earthquake physics via numerical experiments. To be considered successful, the simulations must not only produce observables that are maximally similar to those seen by the PBO and other observing programs, but in addition the simulations must provide dynamical predictions that can be falsified by means of observations on the real fault networks. In general, the dynamical behavior of earthquakes on complex fault networks is a result of the interplay between the geometric structure of the fault network and the physics of the frictional sliding process. In constructing numerical simulations of a complex fault network, we will need to solve a variety of problems, including the development of analysis techniques (also called data mining), data assimilation, space-time pattern definition

  13. Understanding the role of nitrogen in plasma-assisted surface modification of magnetic recording media with and without ultrathin carbon overcoats.

    Science.gov (United States)

    Dwivedi, Neeraj; Yeo, Reuben J; Satyanarayana, Nalam; Kundu, Shreya; Tripathy, S; Bhatia, C S

    2015-01-14

    A novel scheme of pre-surface modification of media using mixed argon-nitrogen plasma is proposed to improve the protection performance of 1.5 nm carbon overcoats (COC) on media produced by a facile pulsed DC sputtering technique. We observe stable and lower friction, higher wear resistance, higher oxidation resistance, and lower surface polarity for the media sample modified in 70%Ar + 30%N2 plasma and possessing 1.5 nm COC as compared to samples prepared using gaseous compositions of 100%Ar and 50%Ar + 50%N2 with 1.5 nm COC. Raman and X-ray photoelectron spectroscopy results suggest that the surface modification process does not affect the microstructure of the grown COC. Instead, the improved tribological, corrosion-resistant and oxidation-resistant characteristics after 70%Ar + 30%N2 plasma-assisted modification can be attributed to, firstly, the enrichment in surface and interfacial bonding, leading to interfacial strength, and secondly, more effective removal of ambient oxygen from the media surface, leading to stronger adhesion of the COC with media, reduction of media corrosion and oxidation, and surface polarity. Moreover, the tribological, corrosion and surface properties of mixed Ar + N2 plasma treated media with 1.5 nm COCs are found to be comparable or better than ~2.7 nm thick conventional COC in commercial media.

  14. Plasmas in Multiphase Media: Bubble Enhanced Discharges in Liquids and Plasma/Liquid Phase Boundaries

    Energy Technology Data Exchange (ETDEWEB)

    Kushner, Mark Jay [University of Michigan

    2014-07-10

    In this research project, the interaction of atmospheric pressure plasmas with multi-phase media was computationally investigated. Multi-phase media includes liquids, particles, complex materials and porous surfaces. Although this investigation addressed fundamental plasma transport and chemical processes, the outcomes directly and beneficially affected applications including biotechnology, medicine and environmental remediation (e.g., water purification). During this project, we made advances in our understanding of the interaction of atmospheric pressure plasmas in the form of dielectric barrier discharges and plasma jets with organic materials and liquids. We also made advances in our ability to use computer modeling to represent these complex processes. We determined the method that atmospheric pressure plasmas flow along solid and liquid surfaces, and through endoscopic like tubes, deliver optical and high energy ion activation energy to organic and liquid surfaces, and produce reactivity in thin liquid layers, as might cover a wound. We determined the mechanisms whereby plasmas can deliver activation energy to the inside of liquids by sustaining plasmas in bubbles. These findings are important to the advancement of new technology areas such as plasma medicine

  15. Plasma Processes: Arc root dynamics in high power plasma torches ...

    Indian Academy of Sciences (India)

    Although plasma torches have been commercially available for about 50 years, areas such as plasma gun design, process efficiency, reproducibility, plasma stability, torch lives etc. have remained mostly unattended. Recent torch developments have been focusing on the basic understanding of the plasma column and its ...

  16. Teaching Teaching & Understanding Understanding

    DEFF Research Database (Denmark)

    2006-01-01

    "Teaching Teaching & Understanding Understanding" is a 19-minute award-winning short-film about teaching at university and higher-level educational institutions. It is based on the "Constructive Alignment" theory developed by Prof. John Biggs. The film delivers a foundation for understanding what...

  17. Systematic understanding of corrosion behavior of plasma electrolytic oxidation treated AZ31 magnesium alloy using a mouse model of subcutaneous implant

    International Nuclear Information System (INIS)

    Jang, Yongseok; Tan, Zongqing; Jurey, Chris; Collins, Boyce; Badve, Aditya; Dong, Zhongyun; Park, Chanhee; Kim, Cheol Sang; Sankar, Jagannathan; Yun, Yeoheung

    2014-01-01

    This study was conducted to identify the differences between corrosion rates, corrosion types, and corrosion products in different physiological environments for AZ31 magnesium alloy and plasma electrolytic oxidation (PEO) treated AZ31 magnesium alloy. In vitro and in vivo tests were performed in Hank's Balanced Salt Solution (HBSS) and mice for 12 weeks, respectively. The corrosion rates of both AZ31 magnesium alloy and PEO treated AZ31 magnesium alloy were calculated based on DC polarization curves, volume of hydrogen evolution, and the thickness of corrosion products formed on the surface. Micro X-ray computed tomography (Micro-CT), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD) were used to analyze morphological and chemical characterizations of corrosion products. The results show that there is more severe localized corrosion after in vitro test in HBSS; however, the thicknesses of corrosion products formed on the surface for AZ31 magnesium alloy and PEO treated AZ31 magnesium alloy in vivo were about 40% thicker than the thickness of corrosion products generated in vitro. The ratio of Ca and P (Ca/P) in the corrosion products also differed. The Ca deficient region and higher content of Al in corrosion product than AZ31 magnesium alloy were identified after in vivo test in contrast with the result of in vitro test. - Highlights: • Effects of plasma electrolytic oxidation on AZ31 in vitro and in vivo • Retardation of degradation via plasma electrolytic oxidation in vitro and in vivo • Differentiation of in vitro and in vivo corrosion types and products

  18. Study of the nucleotide binding site of the yeast Schizosaccharomyces pombe plasma membrane H+-ATPase using formycin triphosphate-terbium complex

    International Nuclear Information System (INIS)

    Ronjat, M.; Lacapere, J.J.; Dufour, J.P.; Dupont, Y.

    1987-01-01

    The plasma membrane of yeasts contains an H+-ATPase similar to the other cation transport ATPases of eukaryotic organisms. This enzyme has been purified and shows H+ transport in reconstituted vesicles. In the presence of Mg2+, formycin triphosphate (FTP) is hydrolyzed by the H+-ATPase and supports H+ transport. When combined with terbium ion, FTP (Tb-FTP) and ATP (Tb-ATP) are no longer hydrolyzed. Competition between Mg-ATP and Tb-FTP for ATP hydrolysis indicates that terbium-associated nucleotides bind to the catalytic site of the H+-ATPase. The fluorescent properties of the Tb-FTP complex were used to study the active site of the H+-ATPase. Fluorescence of Tb-FTP is greatly enhanced upon binding into the nucleotide site of H+-ATPase with a dissociation constant of 1 microM. Tb-ATP, Tb-ADP, and Tb-ITP are competitive inhibitors of Tb-FTP binding with Ki = 4.5, 5.0, and 6.0 microM, respectively. Binding of Tb-FTP is observed only in the presence of an excess of Tb3+ with an activation constant Ka = 25 microM for Tb3+. Analysis of the data reveals that the sites for Tb-FTP and Tb3+ binding are independent entities. In standard conditions these sites would be occupied by Mg-ATP and Mg2+, respectively. These findings suggest an important regulatory role of divalent cations on the activity of H+-ATPase. Replacement of H 2 O by D 2 O in the medium suggests the existence of two types of nucleotide binding sites differing by the hydration state of the Tb3+ ion in the bound Tb-FTP complex

  19. On-line complexation/cloud point preconcentration for the sensitive determination of dysprosium in urine by flow injection inductively coupled plasma-optical emission spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Ortega, Claudia; Cerutti, Soledad; Silva, Maria F. [Departamento de Quimica Analitica, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700, San Luis (Argentina); Olsina, Roberto A.; Martinez, Luis D. [Departamento de Quimica Analitica, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700, San Luis (Argentina); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Avda. Rivadavia 1917, CP C1033AAJJ, Buenos Aires (Argentina)

    2003-01-01

    An on-line dysprosium preconcentration and determination system based on the hyphenation of cloud point extraction (CPE) to flow injection analysis (FIA) associated with ICP-OES was studied. For the preconcentration of dysprosium, a Dy(III)-2-(5-bromo-2-pyridylazo)-5-diethylaminophenol complex was formed on-line at pH 9.22 in the presence of nonionic micelles of PONPE-7.5. The micellar system containing the complex was thermostated at 30 C in order to promote phase separation, and the surfactant-rich phase was retained in a microcolumn packed with cotton at pH 9.2. The surfactant-rich phase was eluted with 4 mol L{sup -1} nitric acid at a flow rate of 1.5 mL min{sup -1}, directly in the nebulizer of the plasma. An enhancement factor of 50 was obtained for the preconcentration of 50 mL of sample solution. The detection limit value for the preconcentration of 50 mL of aqueous solution of Dy was 0.03 {mu}g L{sup -1}. The precision for 10 replicate determinations at the 2.0 {mu}g L{sup -1}Dy level was 2.2% relative standard deviation (RSD), calculated from the peak heights obtained. The calibration graph using the preconcentration system for dysprosium was linear with a correlation coefficient of 0.9994 at levels near the detection limits up to at least 100 {mu}g L {sup -1}. The method was successfully applied to the determination of dysprosium in urine. (orig.)

  20. A Rab11A/myosin Vb/Rab11-FIP2 complex frames two late recycling steps of langerin from the ERC to the plasma membrane.

    Science.gov (United States)

    Gidon, Alexandre; Bardin, Sabine; Cinquin, Bertrand; Boulanger, Jerome; Waharte, François; Heliot, Laurent; de la Salle, Henri; Hanau, Daniel; Kervrann, Charles; Goud, Bruno; Salamero, Jean

    2012-06-01

    A large body of knowledge relating to the constitution of Rab GTPase/Rab effector complexes and their impact on both membrane domain organization and overall membrane trafficking has been built up in recent years. However in the context of the live cell there are still many questions that remain to be answered, such as where and when these complexes assemble and where they perform their primary function(s). We describe here the dynamic processes that take place in the final steps of the Rab11A dependent recycling pathway, in the context of the membrane platform constituted by Myosin Vb, Rab11A, and Rab11-FIP2. We first confirm that a series of previously reported observations obtained during the study of a number of trafficking cargoes also apply to langerin. Langerin is a cargo molecule that traffics through Rab11A-positive membrane domains of the endosomal recycling pathway. In order to explore the relative dynamics of this set of partners, we make extensive use of a combinatory approach of Live-FRET, fast FRAP video, fast confocal and TIRF microscopy modalities. Our data show that the Myosin Vb/Rab11A/Rab11-FIP2 platform is spatially involved in the regulation of langerin trafficking at two distinct sites within live cells, first at the sorting site in the endosomal recycling compartment (ERC) where transport vesicles are formed, and subsequently, in a strict time-defined order, at the very late stage of docking/tethering and fusion of these langerin recycling vesicles to the plasma membrane. © 2012 John Wiley & Sons A/S.

  1. Seasonal changes in plasma levels of sex hormones in the greater Rhea (Rhea americana, a South American Ratite with a complex mating system.

    Directory of Open Access Journals (Sweden)

    Diego J Valdez

    Full Text Available Seasonal rhythm in sex hormones has been extensively studied in birds, as well as its relationship with the type of mating system. The Greater Rhea (Rhea americana, a South American ratite species, reproduces seasonally and has a complex mating system: female-defense polygyny and sequential polyandry. The present study aimed at analyzing the endocrine basis of reproduction in this species and its relationship with its mating system. We used HPLC and electrochemiluminescence techniques to identify and measure plasma testosterone and estradiol levels. Annual oscillations in sex hormones, testosterone and estradiol, in adult males and females were observed. Lower levels of these hormones were exhibited during the non reproductive season (February to July, whereas their maximum values were reached in September for males and November-December for females. These fluctuations reflect the seasonal changes in gonadal function. By contrast, no significant sex hormones oscillations were observed in juvenile males and females (negative control of seasonal changes. Greater rheas maintain high testosterone and estradiol levels throughout the reproductive period. The high testosterone levels during incubation and chick rearing did not inhibit parental behavior in males, which appears not to conform to the "Challenge Hypothesis". In females, the high estradiol levels throughout the reproductive season would be needed to sustain their long egg-laying period.

  2. The attachment of serum- and plasma-derived C3 to solid-phase immune aggregates and its relation to complement-mediated solubilization of immune complexes

    DEFF Research Database (Denmark)

    Baatrup, G; Svehag, S E; Jensenius, J C

    1986-01-01

    The interaction between immune aggregates and complement (C) was investigated. Solid-phase immune aggregates were prepared by coating microwells with heat-aggregated bovine serum albumin (BSA) followed by rabbit anti-BSA antibody. The immune aggregates were reacted with human serum or citrated...... was inhibited, the binding of C3b-iC3b was delayed by 20-30 min, whereas stopping of the alternative pathway did not influence the initial kinetics of the reaction. The addition of human red blood cells had no measurable influence on the degradation of bound C3b-iC3b. 125I-labelled anti-BSA antibody bound...... to the solid-phase BSA was not released during the C3 incorporation. The incorporation of C3b into the immune aggregates was mediated equally well by serum and by citrated plasma. The incorporation of C3b-iC3b into immune complexes (IC) is thought to be responsible for the C-mediated solubilization (CMS) of IC...

  3. Atmospheric pressure plasma and electron cyclotron resonance plasma and their applications

    Science.gov (United States)

    Koretzky, Edward Van

    1999-03-01

    Based on a capacitively coupled electrical discharge scheme, an array of plasma torches is generated to form a dense plasma layer in the open air. In order to use a single power source to supply several torches simultaneously, capacitors are used as ballasting impedances coupling all the torches together. Several diagnostics are performed on a single plasma torch to find its temperature, dimensions, and plasma density. To ease constructing an atmospheric pressure plasma source, a modular system is then presented. The design and construction of the plasma torch module is described. The electrical characteristics of the module is studied for the case of a single module and two capacitively coupled modules. For understanding the plasma torch, each is represented by a parallel RC circuit, in which both R and C are time dependent due to the plasma. The dynamics of the plasma is described by the rate equations for the various plasma species. Numerical simulations have been performed to determine the parameter space for efficient generation of the plasma. Scattering (and absorption) of electromagnetic waves by the plasma torches in a rectangular waveguide is studied experimentally and theoretically. By changing the number of torches appearing in the waveguide, the dependence of the microwave power loss on the plasma volume is determined. ECR plasma-assisted chemical vapor deposition (PACVD) is a technique currently receiving much interest because the ECR plasma system offers a more complex parameter space than the conventional PACVD process. Moreover, a unique feature of the ECR plasma is the production of an energetic electron tail, establishing a large sheath potential on the substrate surface for energizing the bombarding ions, which enhances the nucleation rate. An ECR system for PACVD of diamond film on silicon substrates is designed and built. After surface treatment by the ECR produced energetic ions, the low pressure ECR plasma operation is switched, in situ, to a

  4. Understanding Maple

    CERN Document Server

    Thompson, Ian

    2016-01-01

    Maple is a powerful symbolic computation system that is widely used in universities around the world. This short introduction gives readers an insight into the rules that control how the system works, and how to understand, fix, and avoid common problems. Topics covered include algebra, calculus, linear algebra, graphics, programming, and procedures. Each chapter contains numerous illustrative examples, using mathematics that does not extend beyond first-year undergraduate material. Maple worksheets containing these examples are available for download from the author's personal website. The book is suitable for new users, but where advanced topics are central to understanding Maple they are tackled head-on. Many concepts which are absent from introductory books and manuals are described in detail. With this book, students, teachers and researchers will gain a solid understanding of Maple and how to use it to solve complex mathematical problems in a simple and efficient way.

  5. Understanding corrosion behavior of Mg–Zn–Ca alloys from subcutaneous mouse model: Effect of Zn element concentration and plasma electrolytic oxidation

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Yongseok [Engineering Research Center for Revolutionizing Metallic Biomaterials (ERC-RMB), North Carolina A and T State University, Greensboro, NC 27411 (United States); Tan, Zongqing [Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45221 (United States); Jurey, Chris [Luke Engineering, Wadsworth, OH 44282 (United States); Xu, Zhigang [Engineering Research Center for Revolutionizing Metallic Biomaterials (ERC-RMB), North Carolina A and T State University, Greensboro, NC 27411 (United States); Dong, Zhongyun [Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45221 (United States); Collins, Boyce [Engineering Research Center for Revolutionizing Metallic Biomaterials (ERC-RMB), North Carolina A and T State University, Greensboro, NC 27411 (United States); Yun, Yeoheung, E-mail: yyun@ncat.edu [Engineering Research Center for Revolutionizing Metallic Biomaterials (ERC-RMB), North Carolina A and T State University, Greensboro, NC 27411 (United States); Sankar, Jagannathan [Engineering Research Center for Revolutionizing Metallic Biomaterials (ERC-RMB), North Carolina A and T State University, Greensboro, NC 27411 (United States)

    2015-03-01

    Mg–Zn–Ca alloys are considered as suitable biodegradable metallic implants because of their biocompatibility and proper physical properties. In this study, we investigated the effect of Zn concentration of Mg–xZn–0.3Ca (x = 1, 3 and 5 wt.%) alloys and surface modification by plasma electrolytic oxidation (PEO) on corrosion behavior in in vivo environment in terms of microstructure, corrosion rate, types of corrosion, and corrosion product formation. Microstructure analysis of alloys and morphological characterization of corrosion products were conducted using x-ray computed tomography (micro-CT) and scanning electron microscopy (SEM). Elemental composition and crystal structure of corrosion products were determined using x-ray diffraction (XRD) and electron dispersive x-ray spectroscopy (EDX). The results show that 1) as-cast Mg–xZn–0.3Ca alloys are composed of Mg matrix and a secondary phase of Ca{sub 2}Mg{sub 6}Zn{sub 3} formed along grain boundaries, 2) the corrosion rate of Mg–xZn–0.3Ca alloys increases with increasing concentration of Zn in the alloy, 3) corrosion rates of alloys treated by PEO sample are decreased in in vivo environment, and 4) the corrosion products of these alloys after in vivo tests are identified as brucite (Mg(OH){sub 2}), hydroxyapatite (Ca{sub 10}(PO{sub 4}){sub 6}(OH){sub 2}), and magnesite (MgCO{sub 3}·3H{sub 2}O). - Highlights: • Effects of PEO and Zn concentration in Mg–xZn–0.3Ca alloys on biodegradation • Corrosion rate of Mg–xZn–0.3Ca alloys increases with increasing Zn concentration. • Plasma electrolytic oxidation retards the biodegradation of Mg–xZn–0.3Ca alloys.

  6. EDITORIAL: Gas plasmas in biology and medicine

    Science.gov (United States)

    Stoffels, Eva

    2006-08-01

    It is my great pleasure to introduce this special cluster devoted to recent developments in biomedical plasma technology. It is an even greater pleasure to behold the enormous progress which has been made in this area over the last five years. Research on biomedical plasma applications proceeds hand in hand with the development of new material processing technologies, based on atmospheric plasma sources. In the beginning, major research effort was invested in the development and control of new plasma sources—in this laborious process, novel devices were constructed and characterized, and also new plasma physical phenomena were discovered. Self-constriction of micro-plasmas, pattern formation, filamentation of glow discharges and various mode transitions are just a few examples. It is a real challenge for theorists to gain an understanding of these complex phenomena. Later, the devices had to be thoroughly tested and automated, and various safety issues had to be addressed. At present, many atmospheric plasma sources are ready to use, but not all fundamental and technical problems have been resolved by far. There is still plenty of room for improvement, as in any dynamic area of research. The recent trends are clear: the application area of plasmas expands into processing of unconventional materials such as biological scaffolds, and eventually living human, animal and plant tissues. The gentle, precise and versatile character of cold plasmas simply invites this new application. Firstly, non-living surfaces have been plasma-treated to attain desired effects in biomedical research; tissue engineering will soon fully profit from this powerful technique. Furthermore, studies on cultured plant and animal cells have provided many findings, which are both fundamentally interesting and potentially applicable in health care, veterinary medicine and agriculture. The most important and hitherto unique property of plasma treatment is that it can evade accidental cell death

  7. A Retrospective Propensity Score-Matched Early Thromboembolic Event Analysis of Prothrombin Complex Concentrate vs Fresh Frozen Plasma for Warfarin Reversal Prior to Emergency Neurosurgical Procedures.

    Science.gov (United States)

    Agarwal, Prateek; Abdullah, Kalil G; Ramayya, Ashwin G; Nayak, Nikhil R; Lucas, Timothy H

    2017-06-29

    Reversal of therapeutic anticoagulation prior to emergency neurosurgical procedures is required in the setting of intracranial hemorrhage. Multifactor prothrombin complex concentrate (PCC) promises rapid efficacy but may increase the probability of thrombotic complications compared to fresh frozen plasma (FFP). To compare the rate of thrombotic complications in patients treated with PCC or FFP to reverse therapeutic anticoagulation prior to emergency neurosurgical procedures in the setting of intracranial hemorrhage at a level I trauma center. Sixty-three consecutive patients on warfarin therapy presenting with intracranial hemorrhage who received anticoagulation reversal prior to emergency neurosurgical procedures were retrospectively identified between 2007 and 2016. They were divided into 2 cohorts based on reversal agent, either PCC (n = 28) or FFP (n = 35). The thrombotic complications rates within 72 h of reversal were compared using the χ 2 test. A multivariate propensity score matching analysis was used to limit the threat to interval validity from selection bias arising from differences in demographics, laboratory values, history, and clinical status. Thrombotic complications were uncommon in this neurosurgical population, occurring in 1.59% (1/63) of treated patients. There was no significant difference in the thrombotic complication rate between groups, 3.57% (1/28; PCC group) vs 0% (0/35; FFP group). Propensity score matching analysis validated this finding after controlling for any selection bias. In this limited sample, thrombotic complication rates were similar between use of PCC and FFP for anticoagulation reversal in the management of intracranial hemorrhage prior to emergency neurosurgical procedures. Copyright © 2017 by the Congress of Neurological Surgeons

  8. Predicting Effects of Climate Change on Habitat Suitability of Red Spruce (Picea rubens Sarg. in the Southern Appalachian Mountains of the USA: Understanding Complex Systems Mechanisms through Modeling

    Directory of Open Access Journals (Sweden)

    Kyung Ah Koo

    2015-04-01

    Full Text Available Alpine, subalpine and boreal tree species, of low genetic diversity and adapted to low optimal temperatures, are vulnerable to the warming effects of global climate change. The accurate prediction of these species’ distributions in response to climate change is critical for effective planning and management. The goal of this research is to predict climate change effects on the distribution of red spruce (Picea rubens Sarg. in the Great Smoky Mountains National Park (GSMNP, eastern USA. Climate change is, however, conflated with other environmental factors, making its assessment a complex systems problem in which indirect effects are significant in causality. Predictions were made by linking a tree growth simulation model, red spruce growth model (ARIM.SIM, to a GIS spatial model, red spruce habitat model (ARIM.HAB. ARIM.SIM quantifies direct and indirect interactions between red spruce and its growth factors, revealing the latter to be dominant. ARIM.HAB spatially distributes the ARIM.SIM simulations under the assumption that greater growth reflects higher probabilities of presence. ARIM.HAB predicts the future habitat suitability of red spruce based on growth predictions of ARIM.SIM under climate change and three air pollution scenarios: 10% increase, no change and 10% decrease. Results show that suitable habitats shrink most when air pollution increases. Higher temperatures cause losses of most low-elevation habitats. Increased precipitation and air pollution produce acid rain, which causes loss of both low- and high-elevation habitats. The general prediction is that climate change will cause contraction of red spruce habitats at both lower and higher elevations in GSMNP, and the effects will be exacerbated by increased air pollution. These predictions provide valuable information for understanding potential impacts of global climate change on the spatiotemporal distribution of red spruce habitats in GSMNP.

  9. Understanding corrosion behavior of Mg-Zn-Ca alloys from subcutaneous mouse model: effect of Zn element concentration and plasma electrolytic oxidation.

    Science.gov (United States)

    Jang, Yongseok; Tan, Zongqing; Jurey, Chris; Xu, Zhigang; Dong, Zhongyun; Collins, Boyce; Yun, Yeoheung; Sankar, Jagannathan

    2015-03-01

    Mg-Zn-Ca alloys are considered as suitable biodegradable metallic implants because of their biocompatibility and proper physical properties. In this study, we investigated the effect of Zn concentration of Mg-xZn-0.3Ca (x=1, 3 and 5wt.%) alloys and surface modification by plasma electrolytic oxidation (PEO) on corrosion behavior in in vivo environment in terms of microstructure, corrosion rate, types of corrosion, and corrosion product formation. Microstructure analysis of alloys and morphological characterization of corrosion products were conducted using x-ray computed tomography (micro-CT) and scanning electron microscopy (SEM). Elemental composition and crystal structure of corrosion products were determined using x-ray diffraction (XRD) and electron dispersive x-ray spectroscopy (EDX). The results show that 1) as-cast Mg-xZn-0.3Ca alloys are composed of Mg matrix and a secondary phase of Ca2Mg6Zn3 formed along grain boundaries, 2) the corrosion rate of Mg-xZn-0.3Ca alloys increases with increasing concentration of Zn in the alloy, 3) corrosion rates of alloys treated by PEO sample are decreased in in vivo environment, and 4) the corrosion products of these alloys after in vivo tests are identified as brucite (Mg(OH)2), hydroxyapatite (Ca10(PO4)6(OH)2), and magnesite (MgCO3·3H2O). Copyright © 2014 Elsevier B.V. All rights reserved.

  10. Systematic understanding of corrosion behavior of plasma electrolytic oxidation treated AZ31 magnesium alloy using a mouse model of subcutaneous implant.

    Science.gov (United States)

    Jang, Yongseok; Tan, Zongqing; Jurey, Chris; Collins, Boyce; Badve, Aditya; Dong, Zhongyun; Park, Chanhee; Kim, Cheol Sang; Sankar, Jagannathan; Yun, Yeoheung

    2014-12-01

    This study was conducted to identify the differences between corrosion rates, corrosion types, and corrosion products in different physiological environments for AZ31 magnesium alloy and plasma electrolytic oxidation (PEO) treated AZ31 magnesium alloy. In vitro and in vivo tests were performed in Hank's Balanced Salt Solution (HBSS) and mice for 12 weeks, respectively. The corrosion rates of both AZ31 magnesium alloy and PEO treated AZ31 magnesium alloy were calculated based on DC polarization curves, volume of hydrogen evolution, and the thickness of corrosion products formed on the surface. Micro X-ray computed tomography (Micro-CT), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD) were used to analyze morphological and chemical characterizations of corrosion products. The results show that there is more severe localized corrosion after in vitro test in HBSS; however, the thicknesses of corrosion products formed on the surface for AZ31 magnesium alloy and PEO treated AZ31 magnesium alloy in vivo were about 40% thicker than the thickness of corrosion products generated in vitro. The ratio of Ca and P (Ca/P) in the corrosion products also differed. The Ca deficient region and higher content of Al in corrosion product than AZ31 magnesium alloy were identified after in vivo test in contrast with the result of in vitro test. Copyright © 2014 Elsevier B.V. All rights reserved.

  11. Plasma engineering: a perspective

    International Nuclear Information System (INIS)

    Gralnick, S.L.

    1978-01-01

    This review paper will present the authors perspective of the field of Plasma Engineering as it has evolved over the preceding five years. This embrionic discipline has grown in that period of time to the point where it is sufficiently mature to become part of the curriculum, and a speciality within, the discipline of Nuclear Engineering. Plasma Engineering can be distinguished from the underlying science of plasma physics in that in the pursuit of the latter, our goal is the understanding of the fundamental processes governing the behavior of plasmas while the former discipline seeks the embodiment of these concepts in useful devices. Consequent to this goal, the plasma engineer, of necessity, is concerned with the interfaces between a plasma configuration and the device by which it is produced and maintained. These interface problems, often referred to as kitchen physics are multidisciplinary in nature, and their solution requires careful attention to both plasma physics and machine engineering detail

  12. Atoms in dense plasmas

    Energy Technology Data Exchange (ETDEWEB)

    More, R.M.

    1986-01-01

    Recent experiments with high-power pulsed lasers have strongly encouraged the development of improved theoretical understanding of highly charged ions in a dense plasma environment. This work examines the theory of dense plasmas with emphasis on general rules which govern matter at extreme high temperature and density. 106 refs., 23 figs.

  13. Atoms in dense plasmas

    International Nuclear Information System (INIS)

    More, R.M.

    1986-01-01

    Recent experiments with high-power pulsed lasers have strongly encouraged the development of improved theoretical understanding of highly charged ions in a dense plasma environment. This work examines the theory of dense plasmas with emphasis on general rules which govern matter at extreme high temperature and density. 106 refs., 23 figs

  14. Instabilities, turbulence and transport in a magnetized plasma; Instabilites, turbulence et transport dans un plasma magnetise

    Energy Technology Data Exchange (ETDEWEB)

    Garbet, X

    2001-06-01

    The purpose of this work is to introduce the main processes that occur in a magnetized plasma. During the last 2 decades, the understanding of turbulence has made great progress but analytical formulas and simulations are far to produce reliable predictions. The values of transport coefficients in a tokamak plasma exceed by far those predicted by the theory of collisional transport. This phenomenon is called abnormal transport and might be due to plasma fluctuations. An estimation of turbulent fluxes derived from the levels of fluctuations, is proposed. A flow description of plasma allows the understanding of most micro-instabilities. The ballooning representation deals with instabilities in a toric geometry. 3 factors play an important role to stabilize plasmas: density pinch, magnetic shear and speed shear. The flow model of plasma gives an erroneous value for the stability threshold, this is due to a bad description of the resonant interaction between wave and particle. As for dynamics, flow models can be improved by adding dissipative terms so that the linear response nears the kinetic response. The kinetic approach is more accurate but is complex because of the great number of dimensions involved. (A.C.)

  15. The effects of variable dust size and charge on dust acoustic waves propagating in a hybrid Cairns–Tsallis complex plasma

    Science.gov (United States)

    El-Taibany, W. F.; El-Siragy, N. M.; Behery, E. E.; Elbendary, A. A.; Taha, R. M.

    2018-05-01

    The propagation characteristics of dust acoustic waves (DAWs) in a dusty plasma consisting of variable size dust grains, hybrid Cairns-Tsallis-distributed electrons, and nonthermal ions are studied. The charging of the dust grains is described by the orbital-motion-limited theory and the size of the dust grains obeys the power law dust size distribution. To describe the nonlinear propagation of the DAWs, a Zakharov-Kuznetsov equation is derived using a reductive perturbation method. It is found that the nonthermal and nonextensive parameters influence the main properties of DAWs. Moreover, our results reveal that the rarefactive waves can propagate mainly in the proposed plasma model while compressive waves can be detected for a very small range of the distribution parameters of plasma species, and the DAWs are faster and wider for smaller size dust grains. Applications of the present results to dusty plasma observations are briefly discussed.

  16. Understanding the Mechanism of SiC Plasma-Enhanced Chemical Vapor Deposition (PECVD) and Developing Routes toward SiC Atomic Layer Deposition (ALD) with Density Functional Theory.

    Science.gov (United States)

    Filatova, Ekaterina A; Hausmann, Dennis; Elliott, Simon D

    2018-04-17

    Understanding the mechanism of SiC chemical vapor deposition (CVD) is an important step in investigating the routes toward future atomic layer deposition (ALD) of SiC. The energetics of various silicon and carbon precursors reacting with bare and H-terminated 3C-SiC (011) are analyzed using ab initio density functional theory (DFT). Bare SiC is found to be reactive to silicon and carbon precursors, while H-terminated SiC is found to be not reactive with these precursors at 0 K. Furthermore, the reaction pathways of silane plasma fragments SiH 3 and SiH 2 are calculated along with the energetics for the methane plasma fragments CH 3 and CH 2 . SiH 3 and SiH 2 fragments follow different mechanisms toward Si growth, of which the SiH 3 mechanism is found to be more thermodynamically favorable. Moreover, both of the fragments were found to show selectivity toward the Si-H bond and not C-H bond of the surface. On the basis of this, a selective Si deposition process is suggested for silicon versus carbon-doped silicon oxide surfaces.

  17. ICPP: Introduction to Dusty Plasma Physics

    Science.gov (United States)

    Kant Shukla, Padma

    2000-10-01

    Two omnipresent ingredients of the Universe are plasmas and charged dust. The interplay between these two has opened up a new and fascinating research area, that of dusty plasmas, which are ubiquitous in in different parts of our solar system, namely planetary rings, circumsolar dust rings, interplanetary medium, cometary comae and tails, interstellar molecular clouds, etc. Dusty plasmas also occur in noctilucent clouds in the arctic troposphere and mesosphere, cloud-to-ground lightening in thunderstorms containing smoke-contaminated air over the US, in the flame of humble candle, as well as in microelectronics and in low-temperature laboratory discharges. In the latter, charged dust grains are strongly correlated. Dusty plasma physics has appeared as one of the most rapidly growing field of science, besides the field of the Bose-Einstein condensate, as demonstrated by the number of published papers in scientific journals and conference proceedings. In fact, it is a truly interdisciplinary science because it has many potential applications in astrophysics (viz. in understanding the formation of dust clusters and structures, instabilities of interstellar molecular clouds and star formation, decoupling of magnetic fields from plasmas, etc.) as well as in the planetary magnetospheres of our solar system [viz. the Saturn (particularly, the physics of spokes and braids in B and F rings), Jupiter, Uranus, Neptune, and Mars] and in strongly coupled laboratory dusty plasmas. Since dusty plasma system involves the charging and the dynamics of extremely massive charged dust particulates, it can be characterized as a complex plasma system with new physics insights. In this talk, I shall describe the basic physics of dusty plasmas and present the status of numerous collective processes that are relevant to space research and laboratory experiments. The focus will be on theoretical and experimental observations of novel waves and instabilities, various forces, and some

  18. A survey of dusty plasma physics

    Science.gov (United States)

    Shukla, P. K.

    2001-05-01

    Two omnipresent ingredients of the Universe are plasmas and charged dust. The interplay between these two has opened up a new and fascinating research area, that of dusty plasmas, which are ubiquitous in different parts of our solar system, namely planetary rings, circumsolar dust rings, the interplanetary medium, cometary comae and tails, as well as in interstellar molecular clouds, etc. Dusty plasmas also occur in noctilucent clouds in the arctic troposphere and mesosphere, cloud-to-ground lightening in thunderstorms containing smoke-contaminated air over the United States, in the flame of a humble candle, as well as in microelectronic processing devices, in low-temperature laboratory discharges, and in tokamaks. Dusty plasma physics has appeared as one of the most rapidly growing fields of science, besides the field of the Bose-Einstein condensate, as demonstrated by the number of published papers in scientific journals and conference proceedings. In fact, it is a truly interdisciplinary science because it has many potential applications in astrophysics (viz. in understanding the formation of dust clusters and structures, instabilities of interstellar molecular clouds and star formation, decoupling of magnetic fields from plasmas, etc.) as well as in the planetary magnetospheres of our solar system [viz. Saturn (particularly, the physics of spokes and braids in the B and F rings), Jupiter, Uranus, Neptune, and Mars] and in strongly coupled laboratory dusty plasmas. Since a dusty plasma system involves the charging and dynamics of massive charged dust grains, it can be characterized as a complex plasma system providing new physics insights. In this paper, the basic physics of dusty plasmas as well as numerous collective processes are discussed. The focus will be on theoretical and experimental observations of charging processes, waves and instabilities, associated forces, the dynamics of rotating and elongated dust grains, and some nonlinear structures (such as

  19. Plasma turbulence

    International Nuclear Information System (INIS)

    Horton, W.

    1998-07-01

    The origin of plasma turbulence from currents and spatial gradients in plasmas is described and shown to lead to the dominant transport mechanism in many plasma regimes. A wide variety of turbulent transport mechanism exists in plasmas. In this survey the authors summarize some of the universally observed plasma transport rates

  20. A Characeae Cells Plasma Membrane as a Model for Selection of Bioactive Compounds and Drugs: Interaction of HAMLET-Like Complexes with Ion Channels of Chara corallina Cells Plasmalemma.

    Science.gov (United States)

    Kataev, Anatoly; Zherelova, Olga; Grishchenko, Valery

    2016-12-01

    Interaction of a HAMLET-like La-OA cytotoxic complex (human α-lactalbumin-oleic acid) and its constituents with the excitable plasmalemma of giant Chara corallina cells was investigated. The voltage-clamp technique was used to study Ca 2+ and Cl - transient currents in the plasmalemma of intact cells. The action of the complex and OA on the target cell membrane has a dose-dependent character. It was found that the La-OA complex has an inhibiting effect on Ca 2+ current across the plasmalemma, while α-lactalbumin alone does not affect the electrophysiological characteristics of the cellular membrane. However, oleic acid blocks Ca 2+ current across the plasmalemma. This is accompanied by the induction of a non-selective conductivity in the cellular membrane, a decrease in the resting potential and plasma membrane resistance of algal cells. We propose that the cytotoxicity of La-OA and other HAMLET-like complexes is determined by oleic acid acting as a blocker of potential-dependent Ca 2+ channels in the plasma membrane of target cells. The presented results show that the study model of green algae C. corallina cells plasmalemma is a convenient tool for the investigation of ion channels in many animal cells.

  1. Plasma properties

    International Nuclear Information System (INIS)

    Weitzner, H.

    1990-06-01

    This paper discusses the following topics: MHD plasma activity: equilibrium, stability and transport; statistical analysis; transport studies; edge physics studies; wave propagation analysis; basic plasma physics and fluid dynamics; space plasma; and numerical methods

  2. Complex polarimetric and spectral techniques in diagnostics of blood plasma of patients with ovarian cancer as a preliminary stage molecular genetic screening

    Science.gov (United States)

    Grzegorzewski, B.; Peresunko, O. P.; Yermolenko, S. B.

    2018-01-01

    This work is devoted to the substantiation and selection of patients with ovarian cancer (OC) for the purpose of conducting expensive molecular genetic studies on genotyping. As diagnostic methods have been used ultraviolet spectrometry samples of blood plasma in the liquid state, infrared spectroscopy middle range (2,5 - 25 microns) dry residue of plasma polarization and laser diagnostic technique of thin histological sections of biological tissues. Obtained results showed that the use of spectrophotometry in the range of 1000-3000 cm-1 allowed to establish quantitative parameters of the plasma absorption rate of blood of patients in the third group in different ranges, which would allow in the future to conduct an express analysis of the patient's condition (procedure screening) for further molecular-genetic typing on BRCA I and II.

  3. Understanding the Electronic Structure of 4d Metal Complexes: From Molecular Spinors to L-Edge Spectra of a di-Ru Catalyst

    Energy Technology Data Exchange (ETDEWEB)

    Alperovich, Igor; Smolentsev, Grigory; Moonshiram, Dooshaye; Jurss, Jonah W.; Concepcion, Javier J.; Meyer, Thomas J.; Soldatov, Alexander; Pushkar, Yulia (UNC); (Purdue); (SFU-Russia); (Lund)

    2015-09-17

    L{sub 2,3}-edge X-ray absorption spectroscopy (XAS) has demonstrated unique capabilities for the analysis of the electronic structure of di-Ru complexes such as the blue dimer cis,cis-[Ru{sub 2}{sup III}O(H{sub 2}O){sub 2}(bpy){sub 4}]{sup 4+} water oxidation catalyst. Spectra of the blue dimer and the monomeric [Ru(NH{sub 3}){sub 6}]{sup 3+} model complex show considerably different splitting of the Ru L{sub 2,3} absorption edge, which reflects changes in the relative energies of the Ru 4d orbitals caused by hybridization with a bridging ligand and spin-orbit coupling effects. To aid the interpretation of spectroscopic data, we developed a new approach, which computes L{sub 2,3}-edges XAS spectra as dipole transitions between molecular spinors of 4d transition metal complexes. This allows for careful inclusion of the spin-orbit coupling effects and the hybridization of the Ru 4d and ligand orbitals. The obtained theoretical Ru L{sub 2,3}-edge spectra are in close agreement with experiment. Critically, existing single-electron methods (FEFF, FDMNES) broadly used to simulate XAS could not reproduce the experimental Ru L-edge spectra for the [Ru(NH{sub 3}){sub 6}]{sup 3+} model complex nor for the blue dimer, while charge transfer multiplet (CTM) calculations were not applicable due to the complexity and low symmetry of the blue dimer water oxidation catalyst. We demonstrated that L-edge spectroscopy is informative for analysis of bridging metal complexes. The developed computational approach enhances L-edge spectroscopy as a tool for analysis of the electronic structures of complexes, materials, catalysts, and reactive intermediates with 4d transition metals.

  4. Cold atmospheric plasma sterilization: from bacteria to biomolecules

    Science.gov (United States)

    Kong, Michael

    2009-10-01

    Although ionized gases have been known to have biological effects for more than 100 years, their impact on the practice in healthcare service became very significant only recently. Today, plasma-based surgical tools are used for tissue reduction and blood coagulation as surgical procedures. Most significant however is the speed at which low-temperature gas plasmas are finding new applications in medicine and biology, including plasma sterilization, wound healing, and cancer therapies just to name a few. In the terminology of biotechnology, the ``pipeline'' is long and exciting. This presentation reviews the current status of the field with a particular emphasis on plasma inactivation of microorganisms and biomolecules, for which comprehensive scientific evidence has been obtained. Some of the early speculations of biocidal plasma species are now being confirmed through a combination of optical emission spectroscopy, laser-induced fluorescence, mass spectrometry, fluid simulation and biological sensing with mutated bacteria. Similarly, fundamental studies are being performed to examine cell components targeted by gas plasmas, from membrane, through lipid and membrane proteins, to DNA. Scientific challenge is significant, as the usual complexity of plasma dynamics and plasma chemistry is compounded by the added complication that cells are live and constantly evolving. Nevertheless, the current understanding of plasma inactivation currently provides strong momentum for plasma decontamination technologies to be realized in healthcare. We will discuss the issue of protein and tissue contaminations of surgical instruments and how cold atmospheric plasmas may be used to degrade and reduce their surface load. In the context of plasma interaction with biomolecules, we will consider recent data of plasma degradation of adhesion proteins of melanoma cells. These adhesion proteins are important for cancer cell migration and spread. If low-temperature plasmas could be used to

  5. Plasma harmonics

    CERN Document Server

    Ganeev, Rashid A

    2014-01-01

    Preface; Why plasma harmonics? A very brief introduction Early stage of plasma harmonic studies - hopes and frustrations New developments in plasma harmonics studies: first successes Improvements of plasma harmonics; Theoretical basics of plasma harmonics; Basics of HHG Harmonic generation in fullerenes using few-cycle pulsesVarious approaches for description of observed peculiarities of resonant enhancement of a single harmonic in laser plasmaTwo-colour pump resonance-induced enhancement of odd and even harmonics from a tin plasmaCalculations of single harmonic generation from Mn plasma;Low-o

  6. Understanding the Data Complexity continuum to reduce data management costs and increase data usability through partnerships with the National Centers for Environmental Information

    Science.gov (United States)

    Mesick, S.; Weathers, K. W.

    2017-12-01

    Data complexity can be seen as a continuum from complex to simple. The term data complexity refers to data collections that are disorganized, poorly documented, and generally do not follow best data management practices. Complex data collections are challenging and expensive to manage. Simplified collections readily support automated archival processes, enhanced discovery and data access, as well as production of services that make data easier to reuse. In this session, NOAA NCEI scientific data stewards will discuss the data complexity continuum. This talk will explore data simplification concepts, methods, and tools that data managers can employ which may offer more control over data management costs and processes, while achieving policy goals for open data access and ready reuse. Topics will include guidance for data managers on best allocation of limited data management resources; models for partnering with NCEI to accomplish shared data management goals; and will demonstrate through case studies the benefits of investing in documentation, accessibility, and services to increase data value and return on investment.

  7. Simulation science for fusion plasmas

    International Nuclear Information System (INIS)

    Sudo, S; Skoric, M M; Watanabe, T-H; Todo, Y; Miura, H; Ishizaki, R; Ito, A; Ohtani, H; Ishiguro, S; Tomita, Y; Horiuchi, R; Ishizawa, A; Usami, S; Nakamura, H; Ito, Atsushi; Takayama, A; Sato, M; Yamamoto, T; Den, M; Sakagami, H

    2008-01-01

    The world fusion effort has embarked into a new age with the construction of ITER in Cadarache, France, which will be the first magnetic confinement fusion plasma experiment dominated by the self-heating of fusion reactions. In order to operate and control burning plasmas and next generation demo fusion reactors, an advanced capability for comprehensive integrated computer simulations that are fully verified and validated against experimental data will be necessary. The ultimate goal is to predict reliably the behaviour of plasmas in toroidal magnetic confinement devices on all relevant scales, both in time and space. In addition to developing a sophisticated integrated simulation codes, directed advanced research in fusion physics, applied mathematics, computer science and software is envisaged. In this paper we review the basic strategy and main research efforts at the Department of Simulation Science of the National Institute for Fusion Science (NIFS)- which is the Inter University Institute and the coordinating Center of Excellence for academic fusion research in Japan. We overview a simulation research at NIFS, in particular relation to experiments in the Large Helical Device (LHD), the world's largest superconducting heliotron device, as a National Users' facility (see Motojima et al.). Our main goal is understanding and systemizing the rich hierarchy of physical mechanisms in fusion plasmas, supported by exploring a basic science of complexity of plasma as a highly nonlinear, non-equilibrium, open system. The aim is to establish a simulation science as a new interdisciplinary field by fostering collaborative research in utilizing the large-scale supercomputer simulators. A concept of the hierarchy-renormalized simulation modelling will be invoked en route toward the LHD numerical test reactor.

  8. Bite-angle bending as a key for understanding group-10 metal reactivity of d(10)-[M(NHC)(2)] complexes with sterically modest NHC ligands

    NARCIS (Netherlands)

    Hering, Florian; Nitsch, Joern; Paul, Ursula; Steffen, Andreas; Bickelhaupt, F. Matthias; Radius, Udo

    2014-01-01

    Synthesis, characterization and investigations on the reactivity of the novel metal basic, yet isolable 14 VE NHC-complexes [M0(iPr2Im)2] (M = Pd 3, Pt 4; iPr2Im = 1,3-di-isopropyl-imidazolin-2-ylidene; VE = valence electron; NHC = N-heterocyclic carbene) is reported and compared to the chemistry of

  9. Plasma device

    International Nuclear Information System (INIS)

    Thode, L.E.

    1981-01-01

    A method is described for electron beam heating of a high-density plasma to drive a fast liner. An annular or solid relativistic electron beam is used to heat a plasma to kilovolt temperatures through streaming instabilities in the plasma. Energy deposited in the plasma then converges on a fast liner to explosively or ablatively drive the liner to implosion. (U.K.)

  10. Using ILD or ITD Cues for Sound Source Localization and Speech Understanding in a Complex Listening Environment by Listeners with Bilateral and with Hearing-Preservation Cochlear Implants

    Science.gov (United States)

    Loiselle, Louise H.; Dorman, Michael F.; Yost, William A.; Cook, Sarah J.; Gifford, Rene H.

    2016-01-01

    Purpose: To assess the role of interaural time differences and interaural level differences in (a) sound-source localization, and (b) speech understanding in a cocktail party listening environment for listeners with bilateral cochlear implants (CIs) and for listeners with hearing-preservation CIs. Methods: Eleven bilateral listeners with MED-EL…

  11. Ask, don’t tell : A complex dynamic systems approach to improving science education by focusing on the co-construction of scientific understanding

    NARCIS (Netherlands)

    van Vondel, Sabine; Steenbeek, Henderien; van Dijk, Marijn; van Geert, Paul

    Studying real-time teacher-student interaction provides insight into student's learning processes. In this study, upper grade elementary teachers were supported to optimize their instructional skills required for co-constructing scientific understanding. First, we examined the effect of the Video

  12. Remedial action of matrices contaminated by cobalt with supercritical CO2: contribution to the understanding of the complex formation mechanisms and to the diphasic transfers

    International Nuclear Information System (INIS)

    Gervais, Florence

    2001-01-01

    Soils rehabilitation using supercritical CO 2 seems an interesting alternative way to existing techniques. No effluents are generated during the supercritical fluid extraction, which is the main advantage of this process. In order to be extracted by this techniques, metals or radionuclides have to be complexed by suitable chelating agents. Beta-diketones and dithiocarbamates (fluorinated or not) have been chosen. The first part of this work deals with chemical equilibria mechanisms study in an aqueous phase. Experiments show a very weak cobalt complexation kinetics with acetylacetone. Moreover, this complex exhibit a hydrophilic behaviour. On the other hand, cobalt and dithiocarbamate instantaneously from a chelate which is very hydrophobic. Mass transfer between extracting and aqueous phases (hexane and SC CO 2 ) are also investigated. Supercritical CO 2 seems to have a greater affinity towards fluorinated beta-diketones than hexane. This tendency is confirmed by in situ commercial chelates (fluorinates or not) solubility measurements using X-ray absorption spectroscopy. However, cobalt-beta-diketonates are hydrophilic because of their partial hydration. This kind of chelating agents is not suitable to cobalt supercritical fluid extraction from an aqueous phase. Inversely, distribution coefficients of hydrophobic dithiocarbamates are higher than beta-diketonates, whatever the extracting solvent is. Metals extraction from an aqueous matrix seems possible with these chelating agents. (author) [fr

  13. Stability constants important to the understanding of plutonium in environmental waters, hydroxy and carbonate complexation of PuO2+

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, Dianne Angelo [Univ. of California, Berkeley, CA (United States)

    1990-04-20

    The formation constants for the reactions PuO2+ + H2O = PuO2(OH) + H+ and PuO2+ + CO32- = PuO2(CO3)- were determined in aqueous sodium perchlorate solutions by laser-induced photoacoustic spectroscopy. The molar absorptivity of the PuO2+ band at 569 nm decreased with increasing hydroxide concentration. Similarly, spectral changes occurred between 540 and 580 nm as the carbonate concentration was increased. The absorption data were analyzed by the non-linear least-squares program SQUAD to yield complexation constants. Using the specific ion interaction theory, both complexation constants were extrapolated to zero ionic strength. These thermodynamic complexation constants were combined with the oxidation-reduction potentials of Pu to obtain Eh versus pH diagrams.

  14. The plasma-sheath boundary region

    International Nuclear Information System (INIS)

    Franklin, R N

    2003-01-01

    In this review an attempt is made to give a broad coverage of the problem of joining plasma and sheath over a wide range of physical conditions. We go back to the earliest works quoting them, where appropriate, to understand what those who introduced the various terms associated with the structure of the plasma-sheath had in mind. We try to bring out the essence of the insights that have been gained subsequently, by quoting from the literature selectively, indicating how misunderstandings have arisen. In order to make it accessible to the generality of those currently working in low temperature plasmas we have sought to avoid mathematical complexity but retain physical insight, quoting from published work where appropriate. Nevertheless, in clarifying my own ideas I have found it necessary to do additional original work in order to give a consistent picture. In this way I have sought to bring together work in the late 1920s, the 1960s, and now mindful of the commercial importance of plasma processing, work over the past 15 years that adds to the general understanding. (topical review)

  15. Determination of cisplatin and related platinum complexes in plasma ultrafiltrate and urine by high-performance liquid chromatography with on-line radioactivity detection

    NARCIS (Netherlands)

    Baldew, G S; Volkers, K J; De Goeij, J J; Vermeulen, N P

    1989-01-01

    A reversed-phase ion-pair chromatographic method with on-line radioactivity detection for the simultaneous determination of 195mPt-labelled cisplatin and related platinum complexes has been developed. With this system a good resolution of various radiolabelled platinum complexes can be achieved. The

  16. Theatre pedagogy as an area of negotiating and understanding complex concepts by kindergartners in times of crisis: an intervention-based research study

    OpenAIRE

    Giotaki, Marianna; Lenakakis, Antonis

    2016-01-01

    In this research theatre pedagogy was used to explore kindergartners’ perceptions of the economic crisis and its aspects in their everyday lives, as well as to provide them with opportunities to invest crisis situations with a positive, dynamic meaning, and to shift towards the humanitarian values of justice, active citizenship and understanding the other. Through our theatre-pedagogic programme, a social topic was put forward to the class, and performing arts tools were used to generate a fr...

  17. Microphysics of cosmic plasmas

    CERN Document Server

    Bykov, Andrei; Cargill, Peter; Dendy, Richard; Wit, Thierry; Raymond, John

    2014-01-01

    This title presents a review of the detailed aspects of the physical processes that underlie the observed properties, structures and dynamics of cosmic plasmas. An assessment of the status of understanding of microscale processes in all astrophysical collisionless plasmas is provided. The topics discussed include  turbulence in astrophysical and solar system plasmas as a phenomenological description of their dynamic properties on all scales; observational, theoretical and modelling aspects of collisionless magnetic reconnection; the formation and dynamics of shock waves; and a review and assessment of microprocesses, such as the hierarchy of plasma instabilities, non-local and non-diffusive transport processes and ionisation and radiation processes.  In addition, some of the lessons that have been learned from the extensive existing knowledge of laboratory plasmas as applied to astrophysical problems are also covered.   This volume is aimed at graduate students and researchers active in the areas of cosmi...

  18. Understanding implementation and change in complex interventions. From single- to multi-methodological research on the promotion of youths’ participation in physical education

    DEFF Research Database (Denmark)

    Agergaard, Sine; Dankers, Silke; Munk, Mette

    2018-01-01

    Existing studies on complex interventions aiming to promote youths’ participation in physical education (PE) appear to be predominantly single-methodological. The aim of this article is to examine the benefits and challenges of evaluating an intervention to increase youths’ participation...... and experiences of social inclusion in the PE context using a multi-method approach integrating quantitative and qualitative approaches. The multi-method approach allowed an integration of the findings with regard to the implementation as well as the effect of the intervention. First of all, standardized...

  19. A complexity basis for phenomenology: How information states at criticality offer a new approach to understanding experience of self, being and time.

    Science.gov (United States)

    Hankey, Alex

    2015-12-01

    In the late 19th century Husserl studied our internal sense of time passing, maintaining that its deep connections into experience represent prima facie evidence for it as the basis for all investigations in the sciences: Phenomenology was born. Merleau-Ponty focused on perception pointing out that any theory of experience must accord with established aspects of biology i.e. be embodied. Recent analyses suggest that theories of experience require non-reductive, integrative information, together with a specific property connecting them to experience. Here we elucidate a new class of information states with just such properties found at the loci of control of complex biological systems, including nervous systems. Complexity biology concerns states satisfying self-organized criticality. Such states are located at critical instabilities, commonly observed in biological systems, and thought to maximize information diversity and processing, and hence to optimize regulation. Major results for biology follow: why organisms have unusually low entropies; and why they are not merely mechanical. Criticality states form singular self-observing systems, which reduce wave packets by processes of perfect self-observation associated with feedback gain g = 1. Analysis of their information properties leads to identification of a new kind of information state with high levels of internal coherence, and feedback loops integrated into their structure. The major idea presented here is that the integrated feedback loops are responsible for our 'sense of self', and also the feeling of continuity in our sense of time passing. Long-range internal correlations guarantee a unique kind of non-reductive, integrative information structure enabling such states to naturally support phenomenal experience. Being founded in complexity biology, they are 'embodied'; they also fulfill the statement that 'The self is a process', a singular process. High internal correlations and René Thom

  20. Review on plasmas in extraordinary media: plasmas in cryogenic conditions and plasmas in supercritical fluids

    Science.gov (United States)

    Stauss, Sven; Muneoka, Hitoshi; Terashima, Kazuo

    2018-02-01

    Plasma science and technology has enabled advances in very diverse fields: micro- and nanotechnology, chemical synthesis, materials fabrication and, more recently, biotechnology and medicine. While many of the currently employed plasma tools and technologies are very advanced, the types of plasmas used in micro- and nanofabrication pose certain limits, for example, in treating heat-sensitive materials in plasma biotechnology and plasma medicine. Moreover, many physical properties of plasmas encountered in nature, and especially outer space, i.e. very-low-temperature plasmas or plasmas that occur in high-density media, are not very well understood. The present review gives a short account of laboratory plasmas generated under ’extreme’ conditions: at cryogenic temperatures and in supercritical fluids. The fundamental characteristics of these cryogenic plasmas and cryoplasmas, and plasmas in supercritical fluids, especially supercritical fluid plasmas, are presented with their main applications. The research on such exotic plasmas is expected to lead to further understanding of plasma physics and, at the same time, enable new applications in various technological fields.

  1. Double plasma system with inductively coupled source plasma and quasi-quiescent target plasma

    International Nuclear Information System (INIS)

    Massi, M.; Maciel, H.S.

    1995-01-01

    Cold plasmas have successfully been used in the plasma-assisted material processing industry. An understanding of the physicochemical mechanisms involved in the plasma-surface interaction is needed for a proper description of deposition and etching processes at material surfaces. Since these mechanisms are dependent on the plasma properties, the development of diagnostic techniques is strongly desirable for determination of the plasma parameters as well as the characterization of the electromagnetic behaviour of the discharge. In this work a dual discharge chamber, was specially designed to study the deposition of thin films via plasma polymerization process. In the Pyrex chamber an inductively coupled plasma can be excited either in the diffuse low density E-mode or in the high density H-mode. This plasma diffuses into the cylindrical stainless steel chamber which is covered with permanent magnets to produce a multidipole magnetic field configuration at the surface. By that means a double plasma is established consisting of a RF source plasma coupled to a quasi-quiescent target plasma. The preliminary results presented here refer to measurements of the profiles of plasma parameters along the central axis of the double plasma apparatus. Additionally a spectrum analysis performed by means of a Rogowski coil probe immersed into the source plasma is also presented. The discharge is made in argon with pressure varying from 10 -2 to 1 torr, and the rf from 10 to 150 W

  2. Nonhuman primate models for cell-associated simian immunodeficiency virus transmission: the need to better understand the complexity of HIV mucosal transmission.

    Science.gov (United States)

    Bernard-Stoecklin, Sibylle; Gommet, Céline; Cavarelli, Mariangela; Le Grand, Roger

    2014-12-15

    Nonhuman primates are extensively used to assess strategies to prevent infection from sexual exposure to human immunodeficiency virus (HIV) and to study mechanisms of mucosal transmission. However, although semen represents one of the most important vehicles for the virus, the vast majority of preclinical challenge studies have used cell-free simian immunodeficiency virus (SIV) or simian/human immunodeficiency virus (SHIV) viral particles inoculated as diluted culture supernatants. Semen is a complex body fluid containing many factors that may facilitate or decrease HIV infectiousness. The virus in semen is present in different forms: as free virus particles or as cell-associated virus (ie, within infected leukocytes). Although cell-to-cell transmission of HIV is highly efficient, the role of cell-associated virus in semen has been surprisingly poorly investigated in nonhuman primate models. Mucosal exposure of macaques to cell-associated SIV by using infected peripheral blood mononuclear cells or spleen cells has been shown to be an efficient means of infection; however, it has yet to be shown that SIV- or SHIV-infected seminal leukocytes can transmit infection in vivo. Improvement of animal models to better recapitulate the complex microenvironment at portals of HIV entry is needed for testing candidate antiretrovirals, microbicides, and vaccines. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  3. Plasma astrophysics

    CERN Document Server

    Kaplan, S A; ter Haar, D

    2013-01-01

    Plasma Astrophysics is a translation from the Russian language; the topics discussed are based on lectures given by V.N. Tsytovich at several universities. The book describes the physics of the various phenomena and their mathematical formulation connected with plasma astrophysics. This book also explains the theory of the interaction of fast particles plasma, their radiation activities, as well as the plasma behavior when exposed to a very strong magnetic field. The text describes the nature of collective plasma processes and of plasma turbulence. One author explains the method of elementary

  4. Plasma waves

    CERN Document Server

    Swanson, DG

    1989-01-01

    Plasma Waves discusses the basic development and equations for the many aspects of plasma waves. The book is organized into two major parts, examining both linear and nonlinear plasma waves in the eight chapters it encompasses. After briefly discussing the properties and applications of plasma wave, the book goes on examining the wave types in a cold, magnetized plasma and the general forms of the dispersion relation that characterize the waves and label the various types of solutions. Chapters 3 and 4 analyze the acoustic phenomena through the fluid model of plasma and the kinetic effects. Th

  5. Instabilities, turbulence and transport in a magnetized plasma

    International Nuclear Information System (INIS)

    Garbet, X.

    2001-06-01

    The purpose of this work is to introduce the main processes that occur in a magnetized plasma. During the last 2 decades, the understanding of turbulence has made great progress but analytical formulas and simulations are far to produce reliable predictions. The values of transport coefficients in a tokamak plasma exceed by far those predicted by the theory of collisional transport. This phenomenon is called abnormal transport and might be due to plasma fluctuations. An estimation of turbulent fluxes derived from the levels of fluctuations, is proposed. A flow description of plasma allows the understanding of most micro-instabilities. The ballooning representation deals with instabilities in a toric geometry. 3 factors play an important role to stabilize plasmas: density pinch, magnetic shear and speed shear. The flow model of plasma gives an erroneous value for the stability threshold, this is due to a bad description of the resonant interaction between wave and particle. As for dynamics, flow models can be improved by adding dissipative terms so that the linear response nears the kinetic response. The kinetic approach is more accurate but is complex because of the great number of dimensions involved. (A.C.)

  6. Understanding the Hydro-metathesis Reaction of 1-decene by Using Well-defined Silica Supported W, Mo, Ta Carbene/Carbyne Complexes

    KAUST Repository

    Saidi, Aya

    2017-12-21

    Direct conversion of 1-decene to petroleum range alkanes was obtained using hydro-metathesis reaction. To understand this reaction we employed three different well-defined single site catalysts precursors; [(≡Si-O-)W(CH3)5] 1, [(≡Si-O-)Mo(≡CtBu)(CH2tBu)2] 2 and [(≡Si-O)Ta(=CHtBu)(CH2tBu)2] 3. We witnessed that in our conditions olefin metathesis/isomerization of 1-decene occurs much faster followed by reduction of the newly formed olefins rather than reduction of the 1-decene to decane, followed by metathesis of decane. We found that Mo-based catalyst favors 2+2 cycloaddition of 1-decene forming metallocarbene, followed by reduction of the newly formed olefins to alkanes. However, in the case of W and Ta-based catalysts, a rapid isomerization (migration) of the double bond followed by olefin metathesis and reduction of the newly formed olefins were observed. We witnessed that silica supported W catalyst precursor 1 and Mo catalyst precursor 2 are better catalysts for hydro-metathesis reaction with TONs of 818 and 808 than Ta-based catalyst 3 (TON of 334). This comparison of the catalysts provides us a better understanding that, if a catalyst is efficient in olefin metathesis reaction it would be a better catalyst for hydro-metathesis reaction.

  7. Synthesis, Crystal Structures, Magnetic Properties, and Theoretical Investigation of a New Series of NiII-LnIII-WVHeterotrimetallics: Understanding the SMM Behavior of Mixed Polynuclear Complexes.

    Science.gov (United States)

    Vieru, Veacheslav; Pasatoiu, Traian D; Ungur, Liviu; Suturina, Elizaveta; Madalan, Augustin M; Duhayon, Carine; Sutter, Jean-Pascal; Andruh, Marius; Chibotaru, Liviu F

    2016-12-05

    The polynuclear compounds containing anisotropic metal ions often exhibit efficient barriers for blocking of magnetization at fairly arbitrary geometries. However, at variance with mononuclear complexes, which usually become single-molecule magnets (SMM) under the sole requirement of a highly axial crystal field at the metal ion, the factors influencing the SMM behavior in polynuclear complexes, especially, with weakly axial magnetic ions, still remain largely unrevealed. As an attempt to clarify these conditions, we present here the synthesis, crystal structures, magnetic behavior, and ab initio calculations for a new series of Ni II -Ln III -W V trimetallics, [(CN) 7 W(CN)Ni(H 2 O)(valpn)Ln(H 2 O) 4 ]·H 2 O (Ln = Y 1, Eu 2, Gd 3, Tb 4, Dy 5, Lu 6). The surprising finding is the absence of the magnetic blockage even for compounds involving strongly anisotropic Dy III and Tb III metal ions. This is well explained by ab initio calculations showing relatively large transversal components of the g-tensor in the ground exchange Kramers doublets of 1 and 4 and large intrinsic tunneling gaps in the ground exchange doublets of 3 and 5. In order to get more insight into this behavior, another series of earlier reported compounds with the same trinuclear [W V Ni II Ln III ] core structure, [(CN) 7 W(CN)Ni(dmf)(valdmpn)Ln(dmf) 4 ]·H 2 O (Ln = Gd III 7, Tb III 8a, Dy III 9, Ho III 10), [(CN) 7 W(CN)Ni(H 2 O)(valdmpn)Tb(dmf) 2.5 (H 2 O) 1.5 ]·H 2 O·0.5dmf 8b, and [(CN) 7 W(CN)Ni(H 2 O)(valdmpn)Er(dmf) 3 (H 2 O) 1 ]·H 2 O·0.5dmf 11, has been also investigated theoretically. In this series, only 8b exhibits SMM behavior which is confirmed by the present ab initio calculations. An important feature for the entire series is the strong ferromagnetic coupling between Ni(II) and W(V), which is due to an almost perfect trigonal dodecahedron geometry of the octacyano wolframate fragment. The reason why only 8b is an SMM is explained by positive zero-field splitting on the nickel

  8. Development and application of helicon plasma sources. Evolution of extensive plasma science

    International Nuclear Information System (INIS)

    Shinohara, Shunjiro

    2009-01-01

    Recent advances in plasma science are remarkable, and are deeply indebted to the development of sophisticated plasma sources. While numerous methods have been proposed for producing the plasma, helicon plasma sources, capable of generating high density (>10 13 cm -3 ) plasma with high ionization degree (>several ten percent) over a wide range of external control parameters, have been utilized in such broad areas as fundamental and processing plasmas, nuclear fusion, gas laser, modeling of space plasma, plasma acceleration/propulsion, among others. On the other hand, a number of important issues are left unsolved, in particular, those relevant to the wave phenomena and efficient plasma production. Solution to these issues are expected to play key roles in taking full advantage of the helicon plasma sources in the next generation. In this article, we overview our current understanding of the helicon plasma production and recent development of characteristic helicon plasma sources, and discuss possible future advancement of extensive plasma science utilizing them. (author)

  9. Laser-induced plasmas as an analytical source for quantitative analysis of gaseous and aerosol systems: Fundamentals of plasma-particle interactions

    Science.gov (United States)

    Diwakar, Prasoon K.

    2009-11-01

    Laser-induced Breakdown Spectroscopy (LIBS) is a relatively new analytical diagnostic technique which has gained serious attention in recent past due to its simplicity, robustness, and portability and multi-element analysis capabilities. LIBS has been used successfully for analysis of elements in different media including solids, liquids and gases. Since 1963, when the first breakdown study was reported, to 1983, when the first LIBS experiments were reported, the technique has come a long way, but the majority of fundamental understanding of the processes that occur has taken place in last few years, which has propelled LIBS in the direction of being a well established analytical technique. This study, which mostly focuses on LIBS involving aerosols, has been able to unravel some of the mysteries and provide knowledge that will be valuable to LIBS community as a whole. LIBS processes can be broken down to three basic steps, namely, plasma formation, analyte introduction, and plasma-analyte interactions. In this study, these three steps have been investigated in laser-induced plasma, focusing mainly on the plasma-particle interactions. Understanding plasma-particle interactions and the fundamental processes involved is important in advancing laser-induced breakdown spectroscopy as a reliable and accurate analytical technique. Critical understanding of plasma-particle interactions includes study of the plasma evolution, analyte atomization, and the particle dissociation and diffusion. In this dissertation, temporal and spatial studies have been done to understand the fundamentals of the LIBS processes including the breakdown of gases by the laser pulse, plasma inception mechanisms, plasma evolution, analyte introduction and plasma-particle interactions and their influence on LIBS signal. Spectral measurements were performed in a laser-induced plasma and the results reveal localized perturbations in the plasma properties in the vicinity of the analyte species, for

  10. Plasma device

    International Nuclear Information System (INIS)

    Thode, L.E.

    1981-01-01

    A method is described of providing electron beam heating of a high-density plasma to drive a fast liner to implode a structured microsphere. An annular relativistic electron beam is used to heat an annular plasma to kilovolt temperatures through streaming instabilities in the plasma. Energy deposited in the annular plasma then converges on a fast liner to explosively or ablatively drive the liner to convergence to implode the structured microsphere. (U.K.)

  11. Understanding the visual resource

    Science.gov (United States)

    Floyd L. Newby

    1971-01-01

    Understanding our visual resources involves a complex interweaving of motivation and cognitive recesses; but, more important, it requires that we understand and can identify those characteristics of a landscape that influence the image formation process. From research conducted in Florida, three major variables were identified that appear to have significant effect...

  12. The `What is a system' reflection interview as a knowledge integration activity for high school students' understanding of complex systems in human biology

    Science.gov (United States)

    Tripto, Jaklin; Ben-Zvi Assaraf, Orit; Snapir, Zohar; Amit, Miriam

    2016-03-01

    This study examined the reflection interview as a tool for assessing and facilitating the use of 'systems language' amongst 11th grade students who have recently completed their first year of high school biology. Eighty-three students composed two concept maps in the 10th grade-one at the beginning of the school year and one at its end. The first part of the interview is dedicated to guiding the students through comparing their two concept maps and by means of both explicit and non-explicit teaching. Our study showed that the explicit guidance in comparing the two concept maps was more effective than the non-explicit, eliciting a variety of different, more specific, types of interactions and patterns (e.g. 'hierarchy', 'dynamism', 'homeostasis') in the students' descriptions of the human body system. The reflection interview as a knowledge integration activity was found to be an effective tool for assessing the subjects' conceptual models of 'system complexity', and for identifying those aspects of a system that are most commonly misunderstood.

  13. Understanding the complexity of trans fatty acid reduction in the American diet: American Heart Association Trans Fat Conference 2006: report of the Trans Fat Conference Planning Group.

    Science.gov (United States)

    Eckel, Robert H; Borra, Susan; Lichtenstein, Alice H; Yin-Piazza, Shirley Y

    2007-04-24

    A 2-day forum was convened to discuss the current status and future implications of reducing trans fatty acids without increasing saturated fats in the food supply while maintaining functionality and consumer acceptance of packaged, processed, and prepared foods. Attendees represented the agriculture and oilseed industry and oil processing, food manufacturing, food service, government, food technology, and health and nutrition disciplines. Presentations included food science behind fatty acid technology, the health science of dietary fatty acids, alternatives to trans fatty acids, and the use of alternatives in food manufacturing and food service. The reduction of trans fatty acids in the food supply is a complex issue involving interdependent and interrelated stakeholders. Actions to reduce trans fatty acids need to carefully consider both intended and unintended consequences related to nutrition and public health. The unintended consequence of greatest concern is that fats and oils high in saturated fats, instead of the healthier unsaturated fats, might be used to replace fats and oils with trans fatty acids. Many different options of alternative oils and fats to replace trans fatty acids are available or in development. Decisions on the use of these alternatives need to consider availability, health effects, research and development investments, reformulated food quality and taste, supply-chain management, operational modifications, consumer acceptance, and cost. The conference demonstrated the value of collaboration between the food industry and health and nutrition professionals, and this conference model should be used to address other food development, processing, and/or technology issues.

  14. Numerical simulation of a novel non-transferred arc plasma torch operating with nitrogen

    International Nuclear Information System (INIS)

    Hiremath, Gavisiddayya; Kandasamy, Ramachandran; Ganesh, Ravi

    2015-01-01

    High power plasma torches with higher electro-thermal efficiency are required for industrial applications. To increase the plasma power and electrothermal efficiency, conventional torches are being modified to operate with molecular gases such as air and nitrogen. Since increasing arc current enhances the heat loss to the anode, torches are being developed to operate under high voltage and low current. The plasma flow dynamics and electromagnetic coupling with plasma flow inside the torch etc. are highly complex and knowledge on the same is required to develop high torches with higher efficiency. Unfortunately detailed experimentation on the same is very difficult. Numerical modeling and simulation is one of the best tools to understand the physics involved in such complex processes. A 2D numerical model is developed to simulate the characteristics of the plasma inside the torch. Though plasma is not in local thermodynamic equilibrium (LTE) close to the electrodes, LTE is assumed everywhere in the plasma to avoid complex and time consuming calculations. Other valid assumptions used in the model are plasma flow is optically thin, laminar and incompressible. Flow, energy and electromagnetic equations are solved with appropriate boundary conditions and volume sources using SIMPLE algorithm with finite volume method. Temperature dependent thermophysical properties of nitrogen are used for the simulations. Simulations are carried out for different experimental conditions. The effects of arc current, gas flow rate of plasma generating gas and sheath gas injected above the bottom anode on the arc voltage, electrothermal efficiency of the torch, plasma temperature and plasma velocity are simulated. Predicted results are compared with experimental results. (author)

  15. AN EVALUATION OF THE USEFULNESS OF ACTOR NETWORK THEORY IN UNDERSTANDING THE COMPLEXITIES OF VULNERABILITY AND RESILIENCE IN POST-DISASTER RECONSTRUCTION

    Directory of Open Access Journals (Sweden)

    Graham Brewer

    2013-11-01

    Full Text Available The literature is replete with accounts of the struggle to effectively target and deploy postdisaster aid so as to achieve maximum benefit to recipients, both direct and indirect, over the short- and longer-term. Generally these stories balance success with lessons learned from failure, in order to inform practice in future recovery and reconstruction events. They are often derived from the heroic accounts of key actors in case studies, on the understandable basis that these carefully selected individuals will have been pivotal in designing and directing the implementation of aid programmes. The influence of non-humans such as organisations, systems, processes, or elements of the constructed environment are considered only insofar as they impact upon the experiences of the raconteurs. However actor network theory, a technique originally developed to examine phenomena at the sociotechnological interface, ascribes human characteristics such as motives and behaviours equally to human and non-human actants, ultimately to better explain the worldly consequences of their interaction. This paper reports on the ex post application of ANT to data collected in an earlier actor-centric study, to both evaluate its usefulness in disaster research and to identify potential gaps in the disaster research agenda.

  16. Commentary: An exemplar of progress in understanding complex disorders - reflections on what we have learned about eating disorders (Culbert et al., 2015).

    Science.gov (United States)

    Smith, Gregory T; Davis, Heather A

    2015-11-01

    A number of recent advances in eating disorders research have helped clarify the nature of risk for the development of such disorders. Culbert et al. () provide an empirical and thoughtful review of these recent advances. The authors identified empirically established risk factors in each of several categories of risk for eating disorders: genetic influences, neurotransmitter activity, hormones, personality, and sociocultural influences. We highlight three implications of their review. First, the review can serve as an important asset to eating disorder researchers, both substantively, by providing a comprehensive account of empirically supported risk processes; and methodologically, by highlighting good standards of evidence for acceptance of a candidate risk factor. Second, eating disorder risk is increased by both transdiagnostic and eating disorder-specific factors; there is a need to understand how these types of factors transact with each other. Third and most important, we highlight the importance of Culbert et al.'s advocacy for the development of theoretical models, and empirical tests of those models that specify transactions among different types of risk factors, such as those based on genetic, neurobiological, personality, and social processes. © 2015 Association for Child and Adolescent Mental Health.

  17. Mouse Models of Genomic Syndromes as Tools for Understanding the Basis of Complex Traits: An Example with the Smith-Magenis and the Potocki-Lupski Syndromes

    Science.gov (United States)

    Carmona-Mora, P; Molina, J; Encina, C.A; Walz, K

    2009-01-01

    Each human's genome is distinguished by extra and missing DNA that can be “benign” or powerfully impact everything from development to disease. In the case of genomic disorders DNA rearrangements, such as deletions or duplications, correlate with a clinical specific phenotype. The clinical presentations of genomic disorders were thought to result from altered gene copy number of physically linked dosage sensitive genes. Genomic disorders are frequent diseases (~1 per 1,000 births). Smith-Magenis syndrome (SMS) and Potocki-Lupski syndrome (PTLS) are genomic disorders, associated with a deletion and a duplication, of 3.7 Mb respectively, within chromosome 17 band p11.2. This region includes 23 genes. Both syndromes have complex and distinctive phenotypes including multiple congenital and neurobehavioral abnormalities. Human chromosome 17p11.2 is syntenic to the 32-34 cM region of murine chromosome 11. The number and order of the genes are highly conserved. In this review, we will exemplify how genomic disorders can be modeled in mice and the advantages that such models can give in the study of genomic disorders in particular and gene copy number variation (CNV) in general. The contributions of the SMS and PTLS animal models in several aspects ranging from more specific ones, as the definition of the clinical aspects of the human clinical spectrum, the identification of dosage sensitive genes related to the human syndromes, to the more general contributions as the definition of genetic locus impacting obesity and behavior and the elucidation of general mechanisms related to the pathogenesis of gene CNV are discussed. PMID:19949547

  18. Local modelling techniques for assessing micro-level impacts of risk factors in complex data: understanding health and socioeconomic inequalities in childhood educational attainments.

    Science.gov (United States)

    Zhou, Shang-Ming; Lyons, Ronan A; Bodger, Owen G; John, Ann; Brunt, Huw; Jones, Kerina; Gravenor, Mike B; Brophy, Sinead

    2014-01-01

    Although inequalities in health and socioeconomic status have an important influence on childhood educational performance, the interactions between these multiple factors relating to variation in educational outcomes at micro-level is unknown, and how to evaluate the many possible interactions of these factors is not well established. This paper aims to examine multi-dimensional deprivation factors and their impact on childhood educational outcomes at micro-level, focusing on geographic areas having widely different disparity patterns, in which each area is characterised by six deprivation domains (Income, Health, Geographical Access to Services, Housing, Physical Environment, and Community Safety). Traditional health statistical studies tend to use one global model to describe the whole population for macro-analysis. In this paper, we combine linked educational and deprivation data across small areas (median population of 1500), then use a local modelling technique, the Takagi-Sugeno fuzzy system, to predict area educational outcomes at ages 7 and 11. We define two new metrics, "Micro-impact of Domain" and "Contribution of Domain", to quantify the variations of local impacts of multidimensional factors on educational outcomes across small areas. The two metrics highlight differing priorities. Our study reveals complex multi-way interactions between the deprivation domains, which could not be provided by traditional health statistical methods based on single global model. We demonstrate that although Income has an expected central role, all domains contribute, and in some areas Health, Environment, Access to Services, Housing and Community Safety each could be the dominant factor. Thus the relative importance of health and socioeconomic factors varies considerably for different areas, depending on the levels of each of the other factors, and therefore each component of deprivation must be considered as part of a wider system. Childhood educational achievement could

  19. Particle Simulation of Pulsed Plasma Thruster Plumes

    National Research Council Canada - National Science Library

    Boyd, Ian

    2002-01-01

    .... Our modeling had made progress in al aspects of simulating these complex devices including Teflon ablation, plasma formation, electro-magnetic acceleration, plume expansion, and particulate transport...

  20. Plasma chromatography

    International Nuclear Information System (INIS)

    Anon.

    1984-01-01

    This book examines the fundamental theory and various applications of ion mobility spectroscopy. Plasma chromatography developed from research on the diffusion and mobility of ions. Topics considered include instrument design and description (e.g., performance, spectral interpretation, sample handling, mass spectrometry), the role of ion mobility in plasma chromatography (e.g., kinetic theory of ion transport), atmospheric pressure ionization (e.g., rate equations), the characterization of isomers by plasma chromatography (e.g., molecular ion characteristics, polynuclear aromatics), plasma chromatography as a gas chromatographic detection method (e.g., qualitative analysis, continuous mobility monitoring, quantitative analysis), the analysis of toxic vapors by plasma chromatography (e.g., plasma chromatograph calibration, instrument control and data processing), the analysis of semiconductor devices and microelectronic packages by plasma chromatography/mass spectroscopy (e.g., analysis of organic surface contaminants, analysis of water in sealed electronic packages), and instrument design and automation (hardware, software)

  1. Understanding the complexity of the Lévy-walk nature of human mobility with a multi-scale cost∕benefit model.

    Science.gov (United States)

    Scafetta, Nicola

    2011-12-01

    human mobility, that the proposed model predicts the statistical properties of human mobility below 1 km ranges, where people just walk. In the latter case, the threshold between zone 1 and zone 2 may be around 100-200 m and, perhaps, may have been evolutionary determined by the natural human high resolution visual range, which characterizes an area of interest where the benefits are assumed to be randomly and uniformly distributed. This rich and suggestive interpretation of human mobility may characterize other complex random walk phenomena that may also be described by a N-piece fit Pareto distributions with increasing integer exponents. This study also suggests that distribution functions used to fit experimental probability distributions must be carefully chosen for not improperly obscuring the physics underlying a phenomenon.

  2. Understanding the complexity of the Lévy-walk nature of human mobility with a multi-scale cost/benefit model

    Science.gov (United States)

    Scafetta, Nicola

    2011-12-01

    mobility, that the proposed model predicts the statistical properties of human mobility below 1 km ranges, where people just walk. In the latter case, the threshold between zone 1 and zone 2 may be around 100-200 m and, perhaps, may have been evolutionary determined by the natural human high resolution visual range, which characterizes an area of interest where the benefits are assumed to be randomly and uniformly distributed. This rich and suggestive interpretation of human mobility may characterize other complex random walk phenomena that may also be described by a N-piece fit Pareto distributions with increasing integer exponents. This study also suggests that distribution functions used to fit experimental probability distributions must be carefully chosen for not improperly obscuring the physics underlying a phenomenon.

  3. Understanding Carbohydrates

    Science.gov (United States)

    ... Size: A A A Listen En Español Understanding Carbohydrates How much and what type of carbohydrate foods ... glucose levels in your target range. Explore: Understanding Carbohydrates Glycemic Index and Diabetes Learn about the glycemic ...

  4. Plasma Levels of Monocyte Chemoattractant Protein-1, n-Terminal Fragment of Brain Natriuretic Peptide and Calcidiol Are Independently Associated with the Complexity of Coronary Artery Disease.

    Directory of Open Access Journals (Sweden)

    Roberto Martín-Reyes

    Full Text Available We investigated the relationship of the Syntax Score (SS and coronary artery calcification (CAC, with plasma levels of biomarkers related to cardiovascular damage and mineral metabolism, as there is sparse information in this field.We studied 270 patients with coronary disease that had an acute coronary syndrome (ACS six months before. Calcidiol, fibroblast growth factor-23, parathormone, phosphate and monocyte chemoattractant protein-1 [MCP-1], high-sensitivity C-reactive protein, galectin-3, and N-terminal pro-brain natriuretic peptide [NT-proBNP] levels, among other biomarkers, were determined. CAC was assessed by coronary angiogram as low-grade (0-1 and high-grade (2-3 calcification, measured with a semiquantitative scale ranging from 0 (none to 3 (severe. For the SS study patients were divided in SS<14 and SS≥14. Multivariate linear and logistic regression analyses were performed.MCP-1 predicted independently the SS (RC = 1.73 [95%CI = 0.08-3.39]; p = 0.040, along with NT-proBNP (RC = 0.17 [95%CI = 0.05-0.28]; p = 0.004, male sex (RC = 4.15 [95%CI = 1.47-6.83]; p = 0.003, age (RC = 0.13 [95%CI = 0.02-0.24]; p = 0.020, hypertension (RC = 3.64, [95%CI = 0.77-6.50]; p = 0.013, hyperlipidemia (RC = 2.78, [95%CI = 0.28-5.29]; p = 0.030, and statins (RC = 6.12 [95%CI = 1.28-10.96]; p = 0.013. Low calcidiol predicted high-grade calcification independently (OR = 0.57 [95% CI = 0.36-0.90]; p = 0.013 along with ST-elevation myocardial infarction (OR = 0.38 [95%CI = 0.19-0.78]; p = 0.006, diabetes (OR = 2.35 [95%CI = 1.11-4.98]; p = 0.028 and age (OR = 1.37 [95%CI = 1.18-1.59]; p<0.001. During follow-up (1.79 [0.94-2.86] years, 27 patients developed ACS, stroke, or transient ischemic attack. A combined score using SS and CAC predicted independently the development of the outcome.MCP-1 and NT-proBNP are independent predictors of SS, while low calcidiol plasma levels are associated with CAC. More studies are needed to confirm these data.

  5. Plasma theory and simulation research

    International Nuclear Information System (INIS)

    Birdsall, C.K.

    1989-01-01

    Our research group uses both theory and simulation as tools in order to increase the understanding of instabilities, heating, diffusion, transport and other phenomena in plasmas. We also work on the improvement of simulation, both theoretically and practically. Our focus has been more and more on the plasma edge (the ''sheath''), interactions with boundaries, leading to simulations of whole devices (someday a numerical tokamak)

  6. Complex variables

    CERN Document Server

    Fisher, Stephen D

    1999-01-01

    The most important topics in the theory and application of complex variables receive a thorough, coherent treatment in this introductory text. Intended for undergraduates or graduate students in science, mathematics, and engineering, this volume features hundreds of solved examples, exercises, and applications designed to foster a complete understanding of complex variables as well as an appreciation of their mathematical beauty and elegance. Prerequisites are minimal; a three-semester course in calculus will suffice to prepare students for discussions of these topics: the complex plane, basic

  7. Understanding complex structures in fold-and-thrust belts. Integration of geometric and growth strata analyses, paleomagnetism, AMS and analogue models in the Western termination of the Southern Pyrenees

    Science.gov (United States)

    Pueyo, Emilio L.; Sánchez, Elisa; Oliva-Urcia, Belén; José Ramón, Ma

    2014-05-01

    Classic 2D approaches have helped the understanding of the geometry and kinematics of fold-and-thrust belts belts (FAT belts) but are insufficient to unravel many natural cases. This is because deformation is 3D from the geometric point of view and, thus, cylindrical features may be considered as a simplification. On the other hand, deformation kinematics is usually complex, diachronic and poliphasic in real cases. Therefore, FAT belts have to be always considered in 4D. In this sense, the Southern Pyrenees is a perfect location to study the evolution of FAT belts because of the exceptional outcropping conditions of growth strata, the proven diachronic kinematics and the non-coaxial interference of deformation events. Within the vast catalogue of complex structures that includes superposed folding, conical and plunging folds, oblique thrust ramps, etc here, we have selected the westernmost termination of the South Pyrenean sole thrust to illustrate how the integration of geometric and kinematic analysis can help unraveling complex structures in FAT belts. The San Marzal pericline (4 km2 surface extension) is the lateral termination of the Sto. Domingo deca-kilometric fold. San Marzal looks like a large 70° plunging cylindrical structure. However the large magnitude (≡ 60-70°) of vertical axis rotations accommodated between its flanks cannot be explained without a conical geometry. In this work we will show how the structural analysis performed on this structure has disentangled its complex geometry. This analyses comprises several hundreds of bedding data, joints and veins and more than 150 standard paleomagnetic and AMS sites. Besides, we will show how the kinematic information derived from magnetostratigraphic sections (more than 8 km of sampled profiles) has helped to constraint the folding and rotation ages and velocities. Finally, all these complex geometric and kinematic features have inspired us to build an analogue model where we can explore the 3D

  8. Plasma generator

    International Nuclear Information System (INIS)

    Omichi, Takeo; Yamanaka, Toshiyuki.

    1976-01-01

    Object: To recycle a coolant in a sealed hollow portion formed interiorly of a plasma limiter itself to thereby to cause direct contact between the coolant and the plasma limiter and increase of contact area therebetween to cool the plasma limiter. Structure: The heat resulting from plasma generated during operation and applied to the body of the plasma limiter is transmitted to the coolant, which recycles through an inlet and outlet pipe, an inlet and outlet nozzle and a hollow portion to hold the plasma limiter at a level less than a predetermined temperature. On the other hand, the heater wire is, at the time of emergency operation, energized to heat the plasma limiter, but this heat is transmitted to the limiter body to increase the temperature thereof. However, the coolant recycling the hollow portion comes into direct contact with the limiter body, and since the plasma limiter surround the hollow portion, the heat amount transmitted from the limiter body to the coolant increases to sufficiently cool the plasma limiter. (Yoshihara, H.)

  9. Physical processes in hot cosmic plasmas

    International Nuclear Information System (INIS)

    Fabian, A.G.; Giovannelli, F.

    1990-01-01

    The interpretation of many high energy astrophysical phenomena relies on a detailed knowledge of radiation and transport processes in hot plasmas. The understanding of these plasma properties is one of the aims of terrestrial plasma physics. While the microscopic properties of astrophysical plasmas can hardly be determined experimentally, laboratory plasmas are more easily accessible to experimental techniques, but transient phenomena and the interaction of the plasma with boundaries often make the interpretation of measurements cumbersome. This book contains the talks given at the NATO Advanced Research Workshop on astro- and plasma-physics in Vulcano, Sicily, May 29-June 2, 1989. The book focuses on three main areas: radiation transport processes in hot (astrophysical and laboratory) plasmas; magnetic fields; their generation, reconnection and their effects on plasma transport properties; relativistic and ultra-high density plasmas

  10. Communication Complexity

    Indian Academy of Sciences (India)

    Jaikumar Radhakrishnan

    Communication complexity. Motivation . . . An abstract model to study the communicaiton required for computation. A tool for showing lower bounds in several computational models. The study often requires deep understanding of computation using tools from combinatorics, coding theory, algebra, analysis, etc. Jaikumar ...

  11. Abstracts of 4. IAEA technical meeting on the theory of plasma instabilities

    International Nuclear Information System (INIS)

    2009-05-01

    The Fourth IAEA-TM on Theory of Plasma Instabilities provided a forum for open discussion on theoretical and computational physics issues relevant to burning plasma. The meeting covered linear and non-linear theory and simulation of plasma instabilities, including core/edge turbulence, magneto-hydrodynamic (MHD) process, high energy particle driven dynamics and their effects on plasma confinement. Special attention was paid to the multi-scale interaction dynamics in better understanding the burning plasma and also to the modeling of such complex physical processes. The meeting also organized a panel session to discuss the prospect of plasma theory and simulation for future fusion research for the ITER ERA. Young scientists were enthusiastically encouraged to enjoy this session which may stimulate the research for the future. The meeting covered the following topics: (1) Overview: State of the art and importance of multi-scale physics for understanding burning plasmas; (2) Linear and nonlinear instabilities and their theoretical/computational methodologies including critical gradient problem and comparison with experiments; (3) Core/edge turbulent transport including momentum transport, turbulence-profile interaction and barrier formation, etc and their theoretical/ computational understandings; (4) Magneto-hydrodynamic (MHD) instability including energetic particle physics and their impact on confinement in burning plasmas; (5) Physics and modeling of multi-scale interactions and their impact on the plasma performance and control. Those topics were discussed with close relevance to key experimental results. A panel session 'Theoretical Plasma Physics for the ITER ERA' was organized under interdisciplinary aspects with other fields such as astrophysics and fluid dynamics. Each of the abstracts available has been indexed separately

  12. Mass analysis of an atmospheric pressure plasma needle discharge

    International Nuclear Information System (INIS)

    Malovic, G; Puac, N; Lazovic, S; Petrovic, Z

    2010-01-01

    Mass spectrometric measurements of a plasma needle (an example of atmospheric pressure non-equilibrium plasma source) were made for neutrals and ions. The measurements were performed for the same geometry as the standard plasma needles albeit for a somewhat increased gas flow. We discuss some of the problems of performing mass analysis at atmospheric pressures. The yields of N, O and NO radicals from the plasma needle were determined for different powers of the RF source and different flow rates of working gas. Positive ions generated by the plasma needle itself were measured for the first time. Significant conversion of feed gases (nitrogen and oxygen) into radicals and ions of N and O, and NO was observed as well as depletion of atomic radicals N and O which in chemical reactions form more complex molecules. Biomedical and nanotechnology applications of atmospheric pressure plasmas require a detailed understanding of the source, and mass analysis is perhaps the best technique to focus on chemical kinetics and in many ways interaction with surfaces.

  13. Plasma electrolytic oxidation of A1050 aluminium alloy in homogeneous silicate-alkaline electrolytes with edta{sup 4−} complexes of Fe, Co, Ni, Cu, La and Ba under alternating polarization conditions

    Energy Technology Data Exchange (ETDEWEB)

    Rogov, A.B., E-mail: alex-lab@bk.ru [Nikolaev Institute of Inorganic Chemistry, 3, Acad. Lavrentiev Ave., Novosibirsk, 630090 (Russian Federation); Scientific and Technical Centre “Pokrytie-A” (OOO), 15, Dzerzhinskogo Ave., Novosibirsk, 630015 (Russian Federation)

    2015-11-01

    This work is devoted to the synthesis of coatings containing a number of transition elements by plasma electrolytic oxidation (PEO) on aluminium A1050 alloy. The paper discusses PEO coatings obtained in silicate-alkaline electrolytes containing complexes of Fe, Co, Ni, Cu, La and Ba with ethylenediaminetetraacetic anion edta{sup 4−}. It is also focused on the chemical basis of the electrolyte components choice and their role in the process of PEO. Possible mechanism of coating formation process is also discussed. Alternating current mode (symmetrical sinusoidal current pulses, initial average current density - 100 mA cm{sup −2}) was used to produce the coatings. The PEO process was characterized by behaviours of the anodic and cathodic peak voltage curves. Coating surfaces and cross sections are studied by optical dark field microscopy and scanning electron microscopy, X-ray and energy dispersive analysis. - Highlights: • Alkaline homogeneous electrolyte with transition metal-edta{sup 4-} complexes. • Coatings contain Fe, Co, Ni, Cu, La, Ba elements in alumina-silica matrix. • Alternating symmetric sinusoidal current of 100 mA cm{sup −2} was applied. • Borax buffer solution and silicate passivating agent were used.

  14. On-line complexation of zinc with 5-Br-PADAP and preconcentration using a knotted reactor for inductively coupled plasma atomic emission spectrometric determination in river water samples

    Energy Technology Data Exchange (ETDEWEB)

    Salonia, J.A.; Wuilloud, R.G.; Gasquez, J.A.; Olsina, R.A.; Martinez, L.D. [Area de Quimica Analitica, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700 San Luis (Argentina)

    2000-08-01

    An on-line zinc preconcentration and determination system implemented with inductively coupled plasma atomic emission spectrometry (ICP-AES) associated with flow injection (FI) was studied. The zinc was retained as zinc-2-(5-bromo-2-pyridylazo)-5-diethylaminophenol (Zn-(5-Br-PADAP)) complex at pH 9.2. The zinc complex was removed from the knotted reactor (KR) with 30% v/v nitric acid. An enrichment factor of 42 was obtained for the KR system with respect to ICP-AES using pneumatic nebulization. The detection limit for the preconcentration of 10 mL of aqueous solution was 0.09 {mu}g/L. The precision for 10 replicate determinations at the 5 {mu}g/L Zn level was 2.3% relative standard deviation (RSD), calculated with the peak heights obtained. The calibration graph using the preconcentration system for zinc was linear with a correlation coefficient of 0.9997 at levels near the detection limits up to at least 100 {mu}g/L. The method was succesfully applied to the determination of zinc in river water samples. (orig.)

  15. Bridge between fusion plasma and plasma processing

    International Nuclear Information System (INIS)

    Ohno, Noriyasu; Takamura, Shuichi

    2008-01-01

    In the present review, relationship between fusion plasma and processing plasma is discussed. From boundary-plasma studies in fusion devices new applications such as high-density plasma sources, erosion of graphite in a hydrogen plasma, formation of helium bubbles in high-melting-point metals and the use of toroidal plasmas for plasma processing are emerging. The authors would like to discuss a possibility of knowledge transfer from fusion plasmas to processing plasmas. (T. Ikehata)

  16. Understanding the complexity of human gait dynamics

    Science.gov (United States)

    Scafetta, Nicola; Marchi, Damiano; West, Bruce J.

    2009-06-01

    Time series of human gait stride intervals exhibit fractal and multifractal properties under several conditions. Records from subjects walking at normal, slow, and fast pace speed are analyzed to determine changes in the fractal scalings as a function of the stress condition of the system. Records from subjects with different age from children to elderly and patients suffering from neurodegenerative disease are analyzed to determine changes in the fractal scalings as a function of the physical maturation or degeneration of the system. A supercentral pattern generator model is presented to simulate the above two properties that are typically found in dynamical network performance: that is, how a dynamical network responds to stress and to evolution.

  17. Neuroscience-Enabled Complex Visual Scene Understanding

    Science.gov (United States)

    2012-04-12

    34, Rivista di Psicologia 49 (1): 7–30 • Kauppinen, Hannu. Seppanen, Tapio and Pietikainen, Matti. An Experimental Comparison of Autoregressive and...a Social Robot,“ IJCAI, pp. 1146-1151, 1999. [63] G. Heidemann, R. Rae, H. Bekel, I. Bax, and H. Ritter, ”Inte- grating Context-free and Context... social interaction. In Interna- tional Conference on Robotics, Automation, and Mecha- tronics (RAM 2006), Bangkok Thailand. Se, S., Lowe, D. G

  18. The Science and Technology Challenges of the Plasma-Material Interface for Magnetic Fusion Energy

    Science.gov (United States)

    Whyte, Dennis

    2013-09-01

    The boundary plasma and plasma-material interactions of magnetic fusion devices are reviewed. The boundary of magnetic confinement devices, from the high-temperature, collisionless pedestal through to the surrounding surfaces and the nearby cold high-density collisional plasmas, encompasses an enormous range of plasma and material physics, and their integrated coupling. Due to fundamental limits of material response the boundary will largely define the viability of future large MFE experiments (ITER) and reactors (e.g. ARIES designs). The fusion community faces an enormous knowledge deficit in stepping from present devices, and even ITER, towards fusion devices typical of that required for efficient energy production. This deficit will be bridged by improving our fundamental science understanding of this complex interface region. The research activities and gaps are reviewed and organized to three major axes of challenges: power density, plasma duration, and material temperature. The boundary can also be considered a multi-scale system of coupled plasma and material science regulated through the non-linear interface of the sheath. Measurement, theory and modeling across these scales are reviewed, with a particular emphasis on establishing the use dimensionless parameters to understand this complex system. Proposed technology and science innovations towards solving the PMI/boundary challenges will be examined. Supported by US DOE award DE-SC00-02060 and cooperative agreement DE-FC02-99ER54512.

  19. Plasma properties

    International Nuclear Information System (INIS)

    Weitzner, H.

    1991-06-01

    The Magneto-Fluid Dynamics Division continues to study a broad range of problems originating in plasma physics. Its principal focus is fusion plasma physics, and most particularly topics of particular significance for the world magnetic fusion program. During the calendar year 1990 we explored a wide range of topics including RF-induced transport as a plasma control mechanism, edge plasma modelling, further statistical analysis of L and H mode tokamak plasmas, antenna design, simulation of the edge of a tokamak plasma and the L-H transition, interpretation of the CCT experimental results at UCLA, turbulent transport, studies in chaos, the validity of moment approximations to kinetic equations and improved neoclassical modelling. In more basic studies we examined the statistical mechanisms of Coulomb systems and applied plasma ballooning mode theory to conventional fluids in order to obtain novel fluid dynamics stability results. In space plasma physics we examined the problem of reconnection, the effect of Alfven waves in space environments, and correct formulation of boundary conditions of the Earth for waves in the ionosphere

  20. Plasma container

    International Nuclear Information System (INIS)

    Ebisawa, Katsuyuki.

    1985-01-01

    Purpose: To enable to easily detect that the thickness of material to be abraded is reduced to an allowable limit from the outerside of the plasma container even during usual operation in a plasma vessel for a thermonuclear device. Constitution: A labelled material is disposed to the inside or rear face of constituent members of a plasma container undergoing the irradiation of plasma particles. A limiter plate to be abraded in the plasma container is composed of an armour member and heat removing plate, in which the armour member is made of graphite and heat-removing plate is made of copper. If the armour member is continuously abraded under the effect of sputtering due to plasma particles, silicon nitride embedded so far in the graphite at last appears on the surface of the limiter plate to undergo the impact shocks of the plasma particles. Accordingly, abrasion of the limiter material can be detected by a detector comprising gas chromatography and it can easily be detected from the outside of the plasma content even during normal operation. (Horiuchi, T.)

  1. Understanding classification

    NARCIS (Netherlands)

    Subianto, M.

    2009-01-01

    In practical data analysis, the understandability of models plays an important role in their acceptance. In the data mining literature, however, understandability plays is hardly ever mentioned. If it is mentioned, it is interpreted as meaning that the models have to be simple. In this thesis we

  2. Embodied understanding.

    Science.gov (United States)

    Johnson, Mark

    2015-01-01

    Western culture has inherited a view of understanding as an intellectual cognitive operation of grasping of concepts and their relations. However, cognitive science research has shown that this received intellectualist conception is substantially out of touch with how humans actually make and experience meaning. The view emerging from the mind sciences recognizes that understanding is profoundly embodied, insofar as our conceptualization and reasoning recruit sensory, motor, and affective patterns and processes to structure our understanding of, and engagement with, our world. A psychologically realistic account of understanding must begin with the patterns of ongoing interaction between an organism and its physical and cultural environments and must include both our emotional responses to changes in our body and environment, and also the actions by which we continuously transform our experience. Consequently, embodied understanding is not merely a conceptual/propositional activity of thought, but rather constitutes our most basic way of being in, and engaging with, our surroundings in a deep visceral manner.

  3. PLASMA ENERGIZATION

    Science.gov (United States)

    Furth, H.P.; Chambers, E.S.

    1962-03-01

    BS>A method is given for ion cyclotron resonance heatthg of a magnetically confined plasma by an applied radio-frequency field. In accordance with the invention, the radiofrequency energy is transferred to the plasma without the usual attendent self-shielding effect of plasma polarlzatlon, whereby the energy transfer is accomplished with superior efficiency. More explicitly, the invention includes means for applying a radio-frequency electric field radially to an end of a plasma column confined in a magnetic mirror field configuration. The radio-frequency field propagates hydromagnetic waves axially through the column with the waves diminishing in an intermediate region of the column at ion cyclotron resonance with the fleld frequency. In such region the wave energy is converted by viscous damping to rotational energy of the plasma ions. (AEC)

  4. Plasma device

    International Nuclear Information System (INIS)

    Thode, L.E.

    1981-01-01

    A relativistic electron beam generator or accelerator produces a high-voltage electron beam which is modulated to initiate electron bunching within the beam which is then applied to a high-density target plasma which typically comprises DT, DD, or similar thermonuclear gas at a density of 10 17 to 10 20 electrons per cubic centimeter. As a result, relativistic streaming instabilities are initiated within the high-density target plasma causing the relativistic electron beam to efficiently deposit its energy into a small localized region of the high-density plasma target. The high-temperature plasma can be used to heat a high Z material to generate radiation. Alternatively, a tunable radiation source is produced by using a moderate Z gas or a mixture of high Z and low Z gas as the target plasma. (author)

  5. Plasma-wall interactions

    International Nuclear Information System (INIS)

    Behrisch, Rainer

    1978-01-01

    The plasma wall interactions for two extreme cases, the 'vacuum model' and the 'cold gas blanket' are outlined. As a first step for understanding the plasma wall interactions the elementary interaction processes at the first wall are identified. These are energetic ion and neutral particle trapping and release, ion and neutral backscattering, ion sputtering, desorption by ions, photons and electrons and evaporation. These processes have only recently been started to be investigated in the parameter range of interest for fusion research. The few measured data and their extrapolation into regions not yet investigated are reviewed

  6. Dust-Plasma Interactions

    International Nuclear Information System (INIS)

    Rosenberg, M.

    2010-01-01

    The objective of our theoretical research under this grant over the past 3 years was to develop new understanding in a range of topics in the physics of dust-plasma interactions, with application to space and the laboratory. We conducted studies related to the physical properties of dust, waves and instabilities in both weakly coupled and strongly coupled dusty plasmas, and innovative possible applications. A major consideration in our choice of topics was to compare theory with experiments or observations, and to motivate new experiments, which we believe is important for developing this relatively new field. Our research is summarized, with reference to our list of journal publications.

  7. [Effect on low-molecular-weight heparin obtained using a chitinolytic complex on the anticoagulant activity of plasma in rabbits and rats].

    Science.gov (United States)

    Drozd, N N; Tolstenkov, A S; Makarov, V A; Miftakhova, N T; Bannikova, G E; Sukhanova, P P; Varlamov, V P; Vikhoreva, G E

    2007-01-01

    The anticoagulant activity of low-molecular-weight heparin with an average molecular weight of 4.7 kD (LMWH-4.7) has been studied. This derivative was prepared from unfractionated heparin with the help of chitinolytic enzyme complex from Streptomyces kurssanovii. The antithrombin activity of LMWH-4.7 (aIla activity) was 72 +/- 9 IU/mg and the activity with respect to the blood coagulation factor Xa (aXa activity) was 200 +/- 33 IU/mg, which corresponded to an aXa/aIIa ratio of 2.8 (necessary for effective antithrombotic drugs). The aIIa and aXa activity exhibited a dose-dependent variation upon intravenous and subcutaneous injections in rabbits, so that a high aIIa/aXa ratio was retained: 5 min after the intravenous injection of a minimum dose (0.3 mg/kg), this ratio was 2, 7, and for a greater dose (3.0 mg/kg) it reached 3.8. Subcutaneous injections were followed by slow elimination of the anticoagulant within 24 h. LMWH-4.7 upon intraperitoneal injections produced a dose-dependent inhibition of a model thrombosis in rats. Complete inhibition was observed for a dose of 3 mg/kg. Thus, it is possible to obtain active LMW heparin with the help of chitinases.

  8. Complex Covariance

    Directory of Open Access Journals (Sweden)

    Frieder Kleefeld

    2013-01-01

    Full Text Available According to some generalized correspondence principle the classical limit of a non-Hermitian quantum theory describing quantum degrees of freedom is expected to be the well known classical mechanics of classical degrees of freedom in the complex phase space, i.e., some phase space spanned by complex-valued space and momentum coordinates. As special relativity was developed by Einstein merely for real-valued space-time and four-momentum, we will try to understand how special relativity and covariance can be extended to complex-valued space-time and four-momentum. Our considerations will lead us not only to some unconventional derivation of Lorentz transformations for complex-valued velocities, but also to the non-Hermitian Klein-Gordon and Dirac equations, which are to lay the foundations of a non-Hermitian quantum theory.

  9. Abstracts of 13th International Congress on Plasma Physics (ICPP 2006). Published in 2 volumes

    International Nuclear Information System (INIS)

    Anon

    2006-01-01

    This report contains the presentation on the 13-th International Congress on Plasma Physics (ICPP 2006). Five main topics are covered: fundamental problems of plasma physics; fusion plasmas; plasmas in astrophysics and space physics; plasmas in applications and technologies; complex plasmas

  10. An "on-matrix" digestion procedure for AP-MS experiments dissects the interplay between complex-conserved and serotype-specific reactivities in Dengue virus-human plasma interactome.

    Science.gov (United States)

    Ramos, Yassel; Huerta, Vivian; Martín, Dayron; Palomares, Sucel; Yero, Alexis; Pupo, Dianne; Gallien, Sebastien; Martín, Alejandro M; Pérez-Riverol, Yasset; Sarría, Mónica; Guirola, Osmany; Chinea, Glay; Domon, Bruno; González, Luis Javier

    2017-07-13

    the domain III of the viral envelope glycoprotein. Fifty nine proteins were identified as putative interaction partners of Dengue virus (IPs) either due to direct binding or by co-isolation with interacting proteins. Collectively the IPs identified from the pull-down with the recombinant domain III proteins representing the four viral serotypes, 29% were identified only after "on-matrix" digestion which demonstrate the usefulness of this method of recovering bait-bound proteins. Results highlight a particular importance of "on-matrix" digestion procedure for comparative studies where a stronger interaction with one of the interest baits could prevent a bound protein to elute under standard conditions thus leading to misinterpretation as absent in the interactome of this particular bait. The analysis of the Interaction Network indicates that Dengue virus interactome mediated by the domain III of the envelope protein is rather conserved in the viral complex suggesting a key role of these interactions for viral infection thus making candidates to explore for potential biomarkers of clinical outcome in DENV-caused disease. Interestingly, some particular IPs exhibit significant differences in the strength of the interaction with the viral serotypes representing interactions that involve more variable regions in the surface of the domain III. Since such variable regions are the consequence of the interaction with antibodies generated by human immune response; this result relates the interaction with proteins from human plasma with the interplay of the virus and the human immune system. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Plasma physics of extreme astrophysical environments.

    Science.gov (United States)

    Uzdensky, Dmitri A; Rightley, Shane

    2014-03-01

    Among the incredibly diverse variety of astrophysical objects, there are some that are characterized by very extreme physical conditions not encountered anywhere else in the Universe. Of special interest are ultra-magnetized systems that possess magnetic fields exceeding the critical quantum field of about 44 TG. There are basically only two classes of such objects: magnetars, whose magnetic activity is manifested, e.g., via their very short but intense gamma-ray flares, and central engines of supernovae (SNe) and gamma-ray bursts (GRBs)--the most powerful explosions in the modern Universe. Figuring out how these complex systems work necessarily requires understanding various plasma processes, both small-scale kinetic and large-scale magnetohydrodynamic (MHD), that govern their behavior. However, the presence of an ultra-strong magnetic field modifies the underlying basic physics to such a great extent that relying on conventional, classical plasma physics is often not justified. Instead, plasma-physical problems relevant to these extreme astrophysical environments call for constructing relativistic quantum plasma (RQP) physics based on quantum electrodynamics (QED). In this review, after briefly describing the astrophysical systems of interest and identifying some of the key plasma-physical problems important to them, we survey the recent progress in the development of such a theory. We first discuss the ways in which the presence of a super-critical field modifies the properties of vacuum and matter and then outline the basic theoretical framework for describing both non-relativistic and RQPs. We then turn to some specific astrophysical applications of relativistic QED plasma physics relevant to magnetar magnetospheres and to central engines of core-collapse SNe and long GRBs. Specifically, we discuss the propagation of light through a magnetar magnetosphere; large-scale MHD processes driving magnetar activity and responsible for jet launching and propagation in

  12. Plasma transport in the Scrape-off-Layer of magnetically confined plasma and the plasma exhaust

    DEFF Research Database (Denmark)

    Rasmussen, Jens Juul; Naulin, Volker; Nielsen, Anders Henry

    An overview of the plasma dynamics in the Scrape-off-Layer (SOL) of magnetically confined plasma is presented. The SOL is the exhaust channel of the warm plasma from the core, and the understanding of the SOL plasma dynamics is one of the key issues in contemporary fusion research. It is essential...... for operation of fusion experiments and ultimately fusion power plants. Recent results clearly demonstrate that the plasma transport through the SOL is dominated by turbulent intermittent fluctuations organized into filamentary structures convecting particles, energy, and momentum through the SOL region. Thus......, the transport cannot be described and parametrized by simple diffusive type models. The transport leads to strong localized power loads on the first wall and the plasma facing components, which have serious lasting influence....

  13. Complex Networks

    CERN Document Server

    Evsukoff, Alexandre; González, Marta

    2013-01-01

    In the last decade we have seen the emergence of a new inter-disciplinary field focusing on the understanding of networks which are dynamic, large, open, and have a structure sometimes called random-biased. The field of Complex Networks is helping us better understand many complex phenomena such as the spread of  deseases, protein interactions, social relationships, to name but a few. Studies in Complex Networks are gaining attention due to some major scientific breakthroughs proposed by network scientists helping us understand and model interactions contained in large datasets. In fact, if we could point to one event leading to the widespread use of complex network analysis is the availability of online databases. Theories of Random Graphs from Erdös and Rényi from the late 1950s led us to believe that most networks had random characteristics. The work on large online datasets told us otherwise. Starting with the work of Barabási and Albert as well as Watts and Strogatz in the late 1990s, we now know th...

  14. Understanding semantics

    DEFF Research Database (Denmark)

    Thrane, Torben

    1997-01-01

    Understanding natural language is a cognitive, information-driven process. Discussing some of the consequences of this fact, the paper offers a novel look at the semantic effect of lexical nouns and the identification of reference types....

  15. Understanding Alzheimer's

    Science.gov (United States)

    ... Navigation Bar Home Current Issue Past Issues Understanding Alzheimer's Past Issues / Fall 2007 Table of Contents For ... and brain scans. No treatment so far stops Alzheimer's. However, for some in the disease's early and ...

  16. Advances and challenges in computational plasma science

    International Nuclear Information System (INIS)

    Tang, W M; Chan, V S

    2005-01-01

    Scientific simulation, which provides a natural bridge between theory and experiment, is an essential tool for understanding complex plasma behaviour. Recent advances in simulations of magnetically confined plasmas are reviewed in this paper, with illustrative examples, chosen from associated research areas such as microturbulence, magnetohydrodynamics and other topics. Progress has been stimulated, in particular, by the exponential growth of computer speed along with significant improvements in computer technology. The advances in both particle and fluid simulations of fine-scale turbulence and large-scale dynamics have produced increasingly good agreement between experimental observations and computational modelling. This was enabled by two key factors: (a) innovative advances in analytic and computational methods for developing reduced descriptions of physics phenomena spanning widely disparate temporal and spatial scales and (b) access to powerful new computational resources. Excellent progress has been made in developing codes for which computer run-time and problem-size scale well with the number of processors on massively parallel processors (MPPs). Examples include the effective usage of the full power of multi-teraflop (multi-trillion floating point computations per second) MPPs to produce three-dimensional, general geometry, nonlinear particle simulations that have accelerated advances in understanding the nature of turbulence self-regulation by zonal flows. These calculations, which typically utilized billions of particles for thousands of time-steps, would not have been possible without access to powerful present generation MPP computers and the associated diagnostic and visualization capabilities. In looking towards the future, the current results from advanced simulations provide great encouragement for being able to include increasingly realistic dynamics to enable deeper physics insights into plasmas in both natural and laboratory environments. This

  17. Understanding homelessness

    OpenAIRE

    Somerville, Peter

    2013-01-01

    This paper reviews the literature on understanding homelessness. It criticizes approaches that ignore, distort or diminish the humanity of homeless people, or else, add little to our understanding of that humanity. In particular, it rejects what it calls “epidemiological” approaches, which deny the possibility of agency for homeless people, insofar as those approaches view the situation of those people largely as a “social fact”, to be explained in terms of causal variables or “risk factors” ...

  18. Magnetosphere-ionosphere interactions: Near Earth manifestations of the plasma universe

    Science.gov (United States)

    Faelthammar, Carl-Gunne

    1986-01-01

    As the universe consists almost entirely of plasma, the understanding of astrophysical phenomena must depend critically on the understanding of how matter behaves in the plasma state. In situ observations in the near Earth cosmical plasma offer an excellent opportunity of gaining such understanding. The near Earth cosmical plasma not only covers vast ranges of density and temperature, but is the site of a rich variety of complex plasma physical processes which are activated as a results of the interactions between the magnetosphere and the ionosphere. The geomagnetic field connects the ionosphere, tied by friction to the Earth, and the magnetosphere, dynamically coupled to the solar wind. This causes an exchange of energy an momentum between the two regions. The exchange is executed by magnetic-field-aligned electric currents, the so-called Birkeland currents. Both directly and indirectly (through instabilities and particle acceleration) these also lead to an exchange of plasma, which is selective and therefore causes chemical separation. Another essential aspect of the coupling is the role of electric fields, especially magnetic field aligned (parallel) electric fields, which have important consequences both for the dynamics of the coupling and, especially, for energization of charged particles.

  19. How external osmolarity affects the activity of the contractile vacuole complex, the cytosolic osmolarity and the water permeability of the plasma membrane in Paramecium multimicronucleatum.

    Science.gov (United States)

    Stock, C; Allen, R D; Naitoh, Y

    2001-01-01

    The rate of fluid expulsion, R(CVC), from the contractile vacuole complex (CVC) of Paramecium multimicronucleatum was estimated from the volume of the contractile vacuoles (CVs) immediately before the start of fluid discharge and from the time elapsing between discharges. The R(CVC) increased when the cell was exposed to a strongly hypotonic solution and decreased in a weakly hypotonic solution. When the cell was exposed to an isotonic or a hypertonic solution, R(CVC) fell to zero. The time constant, tau, used to describe the change in R(CVC) in response to a change in external osmolarity shortened after a short-term exposure to a strongly hypotonic solution and lengthened after a short-term exposure to a less hypotonic solution. A remarkable lengthening of tau occurred after a short-term exposure to isotonic or hypertonic solution. Under natural conditions, mechanisms for controlling R(CVC) are effective in maintaining the cytosolic osmolarity hypertonic within a narrow concentration range despite changes in the external osmolarity, which is normally hypotonic to the cytosol. Cells exposed to an isotonic or hypertonic solution resumed CV activity when left in the solution for 12 h. The cytosolic osmolarity was found to increase and to remain hypertonic to the external solution. This will permit cells to continue to acquire water. The increase in the cytosolic osmolarity occurred in a stepwise fashion, rather than linearly, as the external osmolarity increased. That is, the cytosolic osmolarity first remained more-or-less constant at an increased level until the external osmolarity exceeded this level. Thereupon, the cytosolic osmolarity increased to a new higher level in 12 h, so that the cytosol again became hypertonic to the external solution and the cells resumed CV activity. These results imply that the cell needs to maintain water segregation activity even after it has been exposed to an isotonic or hypertonic environment. This supports the idea that the CVC

  20. Plasma cell leukemia

    DEFF Research Database (Denmark)

    Fernández de Larrea, C; Kyle, R A; Durie, B G M

    2013-01-01

    Plasma cell leukemia (PCL) is a rare and aggressive variant of myeloma characterized by the presence of circulating plasma cells. It is classified as either primary PCL occurring at diagnosis or as secondary PCL in patients with relapsed/refractory myeloma. Primary PCL is a distinct clinic......-pathological entity with different cytogenetic and molecular findings. The clinical course is aggressive with short remissions and survival duration. The diagnosis is based upon the percentage (≥ 20%) and absolute number (≥ 2 × 10(9)/l) of plasma cells in the peripheral blood. It is proposed that the thresholds...... regimens and bortezomib-based regimens are recommended followed by high-dose therapy with autologous stem cell transplantation if feasible. Allogeneic transplantation can be considered in younger patients. Prospective multicenter studies are required to provide revised definitions and better understanding...

  1. Remote operation of the vertical plasma stabilization @ the GOLEM tokamak for the plasma physics education

    Energy Technology Data Exchange (ETDEWEB)

    Svoboda, V., E-mail: svoboda@fjfi.cvut.cz [Faculty of Nuclear Sciences and Physical Engineering CTU Prague, CZ-115 19 (Czech Republic); Kocman, J.; Grover, O. [Faculty of Nuclear Sciences and Physical Engineering CTU Prague, CZ-115 19 (Czech Republic); Krbec, J.; Stöckel, J. [Faculty of Nuclear Sciences and Physical Engineering CTU Prague, CZ-115 19 (Czech Republic); Institute of Plasma Physics AS CR, CZ-182 21 Prague (Czech Republic)

    2015-10-15

    Graphical abstract: * Understandable remote operation of a vertical plasma position control system in the tokamak GOLEM for educational purposes.* Two combinable modes of real-time plasma position control: position based feedback and a pre-defined waveform.* More than 20% plasma life prolongation with plasma position control in feedback mode. - Highlights: • Understandable remote operation of a vertical plasma position control system in the tokamak GOLEM for educational purposes. • Two combinable modes of real-time plasma position control: position based feedback and a pre-defined waveform. • More than 20% plasma life prolongation with plasma position control in feedback mode. - Abstract: The GOLEM tokamak at the Czech Technical University has been established as an educational tokamak device for domestic and foreign students. Remote participation in the scope of several laboratory practices, plasma physics schools and workshops has been successfully performed from abroad. A new enhancement allowing understandable remote control of vertical plasma position in two modes (i) predefined and (ii) feedback control is presented. It allows to drive the current in the stabilization coils in any time-dependent scenario, which can include as a parameter the actual plasma position measured by magnetic diagnostics. Arbitrary movement of the plasma column in a vertical direction, stabilization of the plasma column in the center of the tokamak vessel as well as prolongation/shortening of plasma life according to the remotely defined request are demonstrated.

  2. Magnetic stresses in ideal MHD plasmas

    DEFF Research Database (Denmark)

    Jensen, V.O.

    1995-01-01

    The concept of magnetic stresses in ideal MHD plasma theory is reviewed and revisited with the aim of demonstrating its advantages as a basis for calculating and understanding plasma equilibria. Expressions are derived for the various stresses that transmit forces in a magnetized plasma and it is...... and the Shafranov shift. The method had pedagogical merits as it simplifies the calculations, improves the physical understanding and facilitates an assessment of the approximations made in the calculations....

  3. Plasma Cleaning

    Science.gov (United States)

    Hintze, Paul E.

    2016-01-01

    NASA's Kennedy Space Center has developed two solvent-free precision cleaning techniques: plasma cleaning and supercritical carbon dioxide (SCCO2), that has equal performance, cost parity, and no environmental liability, as compared to existing solvent cleaning methods.

  4. Plasma will…

    Czech Academy of Sciences Publication Activity Database

    Lunov, Oleg

    2016-01-01

    Roč. 174, č. 3 (2016), s. 486-487 ISSN 0007-0963 Institutional support: RVO:68378271 Keywords : plasma * ionized gas Subject RIV: BO - Biophysics OBOR OECD: Biophysics Impact factor: 4.706, year: 2016

  5. Plasma technology

    International Nuclear Information System (INIS)

    Drouet, M.G.

    1984-03-01

    IREQ was contracted by the Canadian Electrical Association to review plasma technology and assess the potential for application of this technology in Canada. A team of experts in the various aspects of this technology was assembled and each team member was asked to contribute to this report on the applications of plasma pertinent to his or her particular field of expertise. The following areas were examined in detail: iron, steel and strategic-metals production; surface treatment by spraying; welding and cutting; chemical processing; drying; and low-temperature treatment. A large market for the penetration of electricity has been identified. To build up confidence in the technology, support should be provided for selected R and D projects, plasma torch demonstrations at full power, and large-scale plasma process testing

  6. Plasma chromograninx

    DEFF Research Database (Denmark)

    Goetze, Jens P; Hilsted, Linda M; Rehfeld, Jens F

    2014-01-01

    Cardiovascular risk assessment remains difficult in elderly patients. We examined whether chromogranin A (CgA) measurement in plasma may be valuable in assessing risk of death in elderly patients with symptoms of heart failure in a primary care setting. A total of 470 patients (mean age 73 years......) were followed for 10 years. For CgA plasma measurement, we used a two-step method including a screening test and a confirmative test with plasma pre-treatment with trypsin. Cox multivariable proportional regression and receiver-operating curve (ROC) analyses were used to assess mortality risk...... of follow-up showed significant additive value of CgA confirm measurements compared with NT-proBNP and clinical variables. CgA measurement in the plasma of elderly patients with symptoms of heart failure can identify those at increased risk of short- and long-term mortality....

  7. Plasma confinement

    CERN Document Server

    Hazeltine, R D

    2003-01-01

    Detailed and authoritative, this volume examines the essential physics underlying international research in magnetic confinement fusion. It offers readable, thorough accounts of the fundamental concepts behind methods of confining plasma at or near thermonuclear conditions. Designed for a one- or two-semester graduate-level course in plasma physics, it also represents a valuable reference for professional physicists in controlled fusion and related disciplines.

  8. Understanding Haiti.

    Science.gov (United States)

    Caines, Heather; And Others

    1995-01-01

    Provides teachers, librarians, and general readers with resources to educate themselves and others about the complex reality of today's Haiti. It offers an introduction to Haiti's history, politics, society, and culture and cites works available within the following categories: children's/young adults' books, literature, film and video, and music.…

  9. Managing Complexity

    Energy Technology Data Exchange (ETDEWEB)

    Chassin, David P.; Posse, Christian; Malard, Joel M.

    2004-08-01

    Physical analogs have shown considerable promise for understanding the behavior of complex adaptive systems, including macroeconomics, biological systems, social networks, and electric power markets. Many of today’s most challenging technical and policy questions can be reduced to a distributed economic control problem. Indeed, economically-based control of large-scale systems is founded on the conjecture that the price-based regulation (e.g., auctions, markets) results in an optimal allocation of resources and emergent optimal system control. This paper explores the state of the art in the use physical analogs for understanding the behavior of some econophysical systems and to deriving stable and robust control strategies for them. In particular we review and discussion applications of some analytic methods based on the thermodynamic metaphor according to which the interplay between system entropy and conservation laws gives rise to intuitive and governing global properties of complex systems that cannot be otherwise understood.

  10. Understanding physics

    CERN Document Server

    Mansfield, Michael

    2011-01-01

    Understanding Physics - Second edition is a comprehensive, yet compact, introductory physics textbook aimed at physics undergraduates and also at engineers and other scientists taking a general physics course. Written with today's students in mind, this text covers the core material required by an introductory course in a clear and refreshing way. A second colour is used throughout to enhance learning and understanding. Each topic is introduced from first principles so that the text is suitable for students without a prior background in physics. At the same time the book is designed to enable

  11. Coupling of Plasmas and Liquids

    Science.gov (United States)

    Lindsay, Alexander David

    Plasma-liquids have exciting applications to several important socioeconomic areas, including agriculture, water treatment, and medicine. To realize their application potential, the basic physical and chemical phenomena of plasma-liquid systems must be better understood. Additionally, system designs must be optimized in order to maximize fluxes of critical plasma species to the liquid phase. With objectives to increase understanding of these systems and optimize their applications, we have performed both comprehensive modeling and experimental work. To date, models of plasma-liquids have focused on configurations where diffusion is the dominant transport process in both gas and liquid phases. However, convection plays a key role in many popular plasma source designs, including jets, corona discharges, and torches. In this dissertation, we model momentum, heat, and neutral species mass transfer in a convection-dominated system based on a corona discharge. We show that evaporative cooling produced by gas-phase convection can lead to a significant difference between gas and liquid phase bulk temperatures. Additionally, convection induced in the liquid phase by the gas phase flow substantially increases interfacial mass transfer of hydrophobic species like NO and NO2. Finally, liquid kinetic modeling suggests that concentrations of highly reactive species like OH and ONOOH are several orders of magnitude higher at the interface than in the solution bulk. Subsequent modeling has focused on coupling discharge physics with species transport at and through the interface. An assumption commonly seen in the literature is that interfacial loss coefficients of charged species like electrons are equal to unity. However, there is no experimental evidence to either deny or support this assumption. Without knowing the true interfacial behavior of electrons, we have explored the effects on key plasma-liquid variables of varying interfacial parameters like the electron and energy

  12. Enhancement of food safety – antimicrobial effectiveness of cold plasma treatments

    Directory of Open Access Journals (Sweden)

    Irina SMEU

    2014-08-01

    Full Text Available Cold plasma treatment proved to be a flexible, efficient, chemical-free antimicrobial process and it can represent an easy to use sanitizing method for the food industry that does not require special temperature, humidity or pressure conditions. This paper reviews the classification of plasma and the main cold plasma generating devices used in the recent years to enhance food safety. A research of available literature was also conducted to identify the antimicrobial mode of action of cold plasma treatment as well as advantages and key limitations of this technique when applied to different food products such as fruits, vegetables, meat and milk. The study revealed that further development of this method will have to be carried out, allowing better understanding of the complex interactions during applications and its restrictions, as well as practice outlook.

  13. Plasma sheath: An equivalent nonlinear mirror between electron density and transmitted electromagnetic signal

    Science.gov (United States)

    Yao, Bo; Li, Xiaoping; Shi, Lei; Liu, Yanming; Lei, Fan; Zhu, Congying

    2017-10-01

    An experiment on the propagation of electromagnetic (EM) signals in continuous time-varying plasma is designed to establish the nonlinear mirror between electron density and transmission coefficient. The nonlinearity is confirmed from the theoretical and experimental results. The amplitude and phase can be considered nonlinear functions of electron density when the complex interaction between plasma and EM waves is ignored. Results show that amplitude and phase distributions are asymmetrical when electron density follows symmetric distribution. The skewness of amplitude is positive, whereas the skewness of phase is negative. The nonlinear degree is closely related to the ratio of plasma frequency to the incident wave frequency and the range of electron density. The conclusions are crucial to the modeling of plasma sheath channels and understanding the blackout problem.

  14. Important plasma problems in astrophysics

    International Nuclear Information System (INIS)

    Kulsrud, R.M.

    1995-01-01

    In astrophysics, plasmas occur under very extreme conditions. For example there are ultra strong magnetic fields in neutron stars) relativistic plasmas around black holes and in jets, extremely energetic particles such as cosmic rays in the interstellar medium, extremely dense plasmas in accretion disks, and extremely large magnetic Reynold's numbers in the interstellar medium. These extreme limits for astrophysical plasmas make plasma phenomena much simpler to analyze in astrophysics than in the laboratory. An understanding of such phenomena often results in an interesting way, by simply taking the extreme limiting case of a known plasma theory. I will describe one of the more exciting examples. I will attempt to convey the excitement I felt when I was first exposed to it. However, not all plasma astrophysical phenomena are so simple. There are certain important plasma phenomena in astrophysics, which have not been so easily resolved. In fact a resolution of them is blocking significant progress in astrophysical research. They have not yet yielded to attacks by theoretical astrophysicists nor to extensive numerical simulation. I will attempt to describe one of the more important of these plasma-astrophysical problems, and discuss why its resolution is so important to astrophysics. This significant example is fast, magnetic reconnection. Another significant example is the large-magnetic-Reynold's-number MHD dynamos

  15. Important plasma problems in astrophysics

    International Nuclear Information System (INIS)

    Kulsrud, R.M.

    1995-01-01

    In astrophysics, plasmas occur under very extreme conditions. For example, there are ultrastrong magnetic fields in neutron stars, relativistic plasmas around black holes and in jets, extremely energetic particles such as cosmic rays in the interstellar medium, extremely dense plasmas in accretion disks, and extremely large magnetic Reynolds numbers in the interstellar medium. These extreme limits for astrophysical plasmas make plasma phenomena much simpler to analyze in astrophysics than in the laboratory. An understanding of such phenomena often results in an interesting way, by simply taking the extreme limiting case of a known plasma theory. The author will describe one of the more exciting examples and will attempt to convey the excitement he felt when he was first exposed to it. However, not all plasma astrophysical phenomena are so simple. There are certain important plasma phenomena in astrophysics that have not been so easily resolved. In fact, a resolution of them is blocking significant progress in astrophysical research. They have not yet yielded to attacks by theoretical astrophysicists nor to extensive numerical simulation. The author will attempt to describe one of the more important of these plasma--astrophysical problems, and discuss why its resolution is so important to astrophysics. This significant example is fast, magnetic reconnection. Another significant example is the large-magnetic-Reynolds number magnetohydrodynamics (MHD) dynamos

  16. Understanding Energy

    Science.gov (United States)

    Menon, Deepika; Shelby, Blake; Mattingly, Christine

    2016-01-01

    "Energy" is a term often used in everyday language. Even young children associate energy with the food they eat, feeling tired after playing soccer, or when asked to turn the lights off to save light energy. However, they may not have the scientific conceptual understanding of energy at this age. Teaching energy and matter could be…

  17. Elemental ratios for characterization of quantum-dots populations in complex mixtures by asymmetrical flow field-flow fractionation on-line coupled to fluorescence and inductively coupled plasma mass spectrometry.

    Science.gov (United States)

    Menendez-Miranda, Mario; Fernandez-Arguelles, Maria T; Costa-Fernandez, Jose M; Encinar, Jorge Ruiz; Sanz-Medel, Alfredo

    2014-08-11

    Separation and identification of nanoparticles of different composition, with similar particle diameter, coexisting in heterogeneous suspensions of polymer-coated CdSe/ZnS quantum dots (QDs) have been thoroughly assessed by asymmetric flow field-flow fractionation (AF4) coupled on-line to fluorescence and inductively coupled plasma mass spectrometry (ICPMS) detectors. Chemical characterization of any previously on-line separated nanosized species was achieved by the measurement of the elemental molar ratios of every element involved in the synthesis of the QDs, using inorganic standards and external calibration by flow injection analysis (FIA). Such elemental molar ratios, strongly limited so far to pure single nanoparticles suspensions, have been achieved with adequate accuracy by coupling for the first time an ICP-QQQ instrument to an AF4 system. This hyphenation turned out to be instrumental to assess the chemical composition of the different populations of nanoparticles coexisting in the relatively complex mixtures, due to its capabilities to detect the hardly detectable elements involved in the synthesis. Interestingly such information, complementary to that obtained by fluorescence, was very valuable to detect and identify unexpected nanosized species, present at significant level, produced during QDs synthesis and hardly detectable by standard approaches. Copyright © 2014. Published by Elsevier B.V.

  18. Complex analysis

    CERN Document Server

    Freitag, Eberhard

    2005-01-01

    The guiding principle of this presentation of ``Classical Complex Analysis'' is to proceed as quickly as possible to the central results while using a small number of notions and concepts from other fields. Thus the prerequisites for understanding this book are minimal; only elementary facts of calculus and algebra are required. The first four chapters cover the essential core of complex analysis: - differentiation in C (including elementary facts about conformal mappings) - integration in C (including complex line integrals, Cauchy's Integral Theorem, and the Integral Formulas) - sequences and series of analytic functions, (isolated) singularities, Laurent series, calculus of residues - construction of analytic functions: the gamma function, Weierstrass' Factorization Theorem, Mittag-Leffler Partial Fraction Decomposition, and -as a particular highlight- the Riemann Mapping Theorem, which characterizes the simply connected domains in C. Further topics included are: - the theory of elliptic functions based on...

  19. Atrial natriuretic peptides in plasma

    DEFF Research Database (Denmark)

    Goetze, Jens Peter; Hansen, Lasse H; Terzic, Dijana

    2014-01-01

    Measurement of cardiac natriuretic peptides in plasma has gained a diagnostic role in the assessment of heart failure. Plasma measurement is though hampered by the marked instability of the hormones, which has led to the development of analyses that target N-terminal fragments from the prohormone....... These fragments are stable in plasma and represent surrogate markers of the actual natriuretic hormone. Post-translational processing of the precursors, however, is revealing itself to be a complex event with new information still being reported on proteolysis, covalent modifications, and amino acid...

  20. Contact activation of blood-plasma coagulation

    Science.gov (United States)

    Golas, Avantika

    Surface engineering of biomaterials with improved hemocompatibility is an imperative, given the widespread global need for cardiovascular devices. Research summarized in this dissertation focuses on contact activation of FXII in buffer and blood plasma frequently referred to as autoactivation. The extant theory of contact activation imparts FXII autoactivation ability to negatively charged, hydrophilic surfaces. According to this theory, contact activation of plasma involves assembly of proteins comprising an "activation complex" on activating surfaces mediated by specific chemical interactions between complex proteins and the surface. This work has made key discoveries that significantly improve our core understanding of contact activation and unravel the existing paradigm of plasma coagulation. It is shown herein that contact activation of blood factor XII (FXII, Hageman factor) in neat-buffer solution exhibits a parabolic profile when scaled as a function of silanized-glass-particle activator surface energy (measured as advancing water adhesion tension t°a=g° Iv costheta in dyne/cm, where g°Iv is water interfacial tension in dyne/cm and theta is the advancing contact angle). Nearly equal activation is observed at the extremes of activator water-wetting properties --36 < t°a < 72 dyne/cm (O° ≤ theta < 120°), falling sharply through a broad minimum within the 20 < t°a < 40 dyne/cm (55° < theta < 75°). Furthermore, contact activation of FXII in buffer solution produces an ensemble of protein fragments exhibiting either procoagulant properties in plasma (proteolysis of blood factor XI or prekallikrein), amidolytic properties (cleavage of s-2302 chromogen), or the ability to suppress autoactivation through currently unknown biochemistry. The relative proportions of these fragments depend on activator surface chemistry/energy. We have also discovered that contact activation is moderated by adsorption of plasma proteins unrelated to coagulation through an

  1. Physical domains in plasma physics

    International Nuclear Information System (INIS)

    Liboff, R.L.

    1987-01-01

    Do the plasma in the sun's core and the electron-conduction plasma in a semiconductor behave in the same way? This question is both fundamental and practical, for plasma physics plays a role in a vast area of natural phenomena and in many engineering devices. Understanding the cosmos, or designing a computer chip or a thermonuclear fusion reactor, requires first of all a realization of equations of motion that are appropriate to the particular problem. Similar physical differences occur in engineered structures. The plasmas in most thermonuclear fusion devices are basically like the plasma in the core of the sun: weakly coupled and classical - that is, obeying Newton's laws and Maxwell's equations. The conduction electrons in a semiconductor, on the other hand, obey the laws of quantum mechanics

  2. Cold plasmas

    International Nuclear Information System (INIS)

    Franz, G.

    1990-01-01

    This textbook discusses the following topics: Phenomenological description of a direct current glow discharge; the plasma (temperature distribution and measurement, potential variation, electron energy distribution function, charge neutralization, wall potentials, plasma oscillations); Production of charge carriers (ions, electrons, ionization in the cathode zone, negative glowing zone, Faraday dark space, positive column, anode zone, hollow cathode discharges); RF-discharges (charge carrier production, RF-Shields, scattering mechanisms); Sputtering (ion-surface interaction, kinetics, sputtering yield and energy distribution, systems and conditions, film formation and stresses, contamination, bias techniques, multicomponent film deposition, cohesion, magnetrons, triode systems, plasma enhanced chemical vapor deposition); Dry etching (sputter etching, reactive etching, topography, process control, quantitative investigations); Etching mechanisms (etching of Si and SiO 2 with CF 4 , of III/V-compound-semiconductors, combination of isotrope and anisotrope etching methods, surface cleaning); ion beam systems (applications, etching); Dyclotron-resonance-systems (electron cyclotron resonance systems, whistler-sources and 'resonant inductive plasma etching'); Appendix (electron energy distribution functions, Bohm's transition zone, plasma oscillations, scattering cross sections and mean free path, metastable states, Child-Langmuir-Schottky equation, loss mechanisms, charge carrier distribution in the positive column, breakdown at high frequencies, motion in a magnetic field, skin depth of an electric field for a HF-discharge, whistler waves, dispersion relations for plane wave propagation). (orig.) With 138 figs

  3. FOREWORD: 23rd National Symposium on Plasma Science & Technology (PLASMA-2008)

    Science.gov (United States)

    Das, A. K.

    2010-01-01

    The Twentieth Century has been a defining period for Plasma Science and Technology. The state of ionized matter, so named by Irving Langmuir in the early part of twentieth century, has now evolved in to a multidisciplinary area with scientists and engineers from various specializations working together to exploit the unique properties of the plasma medium. There have been great improvements in the basic understanding of plasmas as a many body system bound by complex collective Coulomb interactions of charges, atoms, molecules, free radicals and photons. Simultaneously, many advanced plasma based technologies are increasingly being implemented for industrial and societal use. The emergence of the multination collaborative project International Thermonuclear Experimental Reactor (ITER) project has provided the much needed boost to the researchers working on thermonuclear fusion plasmas. In addition, the other plasma applications like MHD converters, hydrogen generation, advanced materials (synthesis, processing and surface modification), environment (waste beneficiation, air and water pollution management), nanotechnology (synthesis, deposition and etching), light production, heating etc are actively being pursued in governmental and industrial sectors. For India, plasma science and technology has traditionally remained an important area of research. It was nearly a century earlier that the Saha ionization relation pioneered the way to interpret experimental data from a vast range of near equilibrium plasmas. Today, Indian research contributions and technology demonstration capabilities encompass thermonuclear fusion devices, nonlinear plasma phenomena, plasma accelerators, beam plasma interactions, dusty and nonneutral plasmas, industrial plasmas and plasma processing of materials, nano synthesis and structuring, astrophysical and space plasmas etc. India's participation in the ITER programme is now reflected in increased interest in the research and development

  4. EDITORIAL: 80 Years of Plasma 80 Years of Plasma

    Science.gov (United States)

    Franklin, R. N.; Braithwaite, N. St J.

    2009-02-01

    Irving Langmuir proposed the term 'plasma' in a paper in 1928 (Proc. Natl Acad. Sci. USA 14 627-637) to describe a 'region containing balanced charges of ions and electrons'. There does not appear to be any record of the thinking behind this proposal, so it is difficult to be definitive. One idea is that since the Greek word 'plasma' was used to describe a mouldable fluid, 'neon' lighting, with its almost limitless ability to provide colourful shapes, provided the inspiration. Another relates to the prior medical use in relation to blood with its variety of different 'corpuscles' and that the essential description of the positive column required one to recognize at least the role of the separate species of electrons, ions and gas atoms. Tonks, when questioned thirty years later, was inclined to the latter idea, but it is unlikely that we shall ever know for certain. (See postscript added December 2008.) Forty years ago most of the interest in terrestrial plasmas was centred on fusion and the prospect of thus solving the world's energy problems; the quest continues. However, since then a whole new industry has developed. It emerged in the 1970s as an imaginative way to remove the photoresist layers used in patterning semiconductor wafers. Slowly but steadily, plasma-based 'dry' processes began to displace the traditional wet chemistry processes of cleaning, etching and depositing by which the first generation of integrated circuits had been made. Plasma technology offered higher yields while accommodating the complexity of ever-shrinking feature size, driving the microelectronic revolution for almost four decades. Langmuir certainly ushered in an exciting branch of physics when he introduced the term plasma. We have included as Appendix I a condensed CV for Irving Langmuir to show, amongst other things, the early influences on his subsequent life. An interlude in Paris gave him a taste of the wider world of Europe. His subsequent schooling in the United States led

  5. Understanding translation

    DEFF Research Database (Denmark)

    Schjoldager, Anne Gram; Gottlieb, Henrik; Klitgård, Ida

    Understanding Translation is designed as a textbook for courses on the theory and practice of translation in general and of particular types of translation - such as interpreting, screen translation and literary translation. The aim of the book is to help you gain an in-depth understanding...... of the phenomenon of translation and to provide you with a conceptual framework for the analysis of various aspects of professional translation. Intended readers are students of translation and languages, but the book will also be relevant for others who are interested in the theory and practice of translation...... - translators, language teachers, translation users and literary, TV and film critics, for instance. Discussions focus on translation between Danish and English....

  6. Understanding Resilience

    Directory of Open Access Journals (Sweden)

    Gang eWu

    2013-02-01

    Full Text Available Resilience is the ability to adapt successfully in the face of stress and adversity. Stressful life events, trauma and chronic adversity can have a substantial impact on brain function and structure, and can result in the development of PTSD, depression and other psychiatric disorders. However, most individuals do not develop such illnesses after experiencing stressful life events, and are thus thought to be resilient. Resilience as successful adaptation relies on effective responses to environmental challenges and ultimate resistance to the deleterious effects of stress, therefore a greater understanding of the factors that promote such effects is of great relevance. This review focuses on recent findings regarding genetic, epigenetic, developmental, psychosocial and neurochemical factors that are considered essential contributors to the development of resilience. Neural circuits and pathways involved in mediating resilience are also discussed. The growing understanding of resilience factors will hopefully lead to the development of new pharmacological and psychological interventions for enhancing resilience and mitigating the untoward consequences.

  7. Understand electronics

    CERN Document Server

    Bishop, Owen

    2013-01-01

    Understand Electronics provides a readable introduction to the exciting world of electronics for the student or enthusiast with little previous knowledge. The subject is treated with the minimum of mathematics and the book is extensively illustrated.This is an essential guide for the newcomer to electronics, and replaces the author's best-selling Beginner's Guide to Electronics.The step-by-step approach makes this book ideal for introductory courses such as the Intermediate GNVQ.

  8. Understanding users

    DEFF Research Database (Denmark)

    Johannsen, Carl Gustav Viggo

    2014-01-01

    Segmentation of users can help libraries in the process of understanding user similarities and differences. Segmentation can also form the basis for selecting segments of target users and for developing tailored services for specific target segments. Several approaches and techniques have been...... segmentation project using computer-generated clusters. Compared to traditional marketing texts, this article also tries to identify user segments or images or metaphors by the library profession itself....

  9. Understanding unemployment

    OpenAIRE

    Guillaume Rocheteau

    2006-01-01

    Modern economists have built models of the labor market, which isolate the market’s key drivers and describe the way these interact to produce particular levels of unemployment. One of the most popular models used by macroeconomists today is the search-matching model of equilibrium unemployment. We explain this model, and show how it can be applied to understand the way various policies, such as unemployment benefits, taxes, or technological changes, can affect the unemployment rate.

  10. Understanding Technology?

    Directory of Open Access Journals (Sweden)

    Erik Bendtsen

    2016-11-01

    Full Text Available We are facing radical changes in our ways of living in the nearest future. Not necessarily of our own choice, but because tchnological development is moving so fast, that it will have still greater impact on many aspects of our lives. We have seen the beginnings of that change within the latest 35 years or so, but according to newest research that change will speed up immensely in the nearest years to come. The impact of that change or these changes will affect our working life immensely as a consequence of automation. How these changes are brought about and which are their consequences in a broad sense is being attempted to be understood and guessed by researchers. No one knows for sure, but specific patterns are visible. This paper will not try to guess, what will come, but will rather try to understand the deepest ”nature” of technology in order to understand the driving factors in this development: the genesis of technology in a broad sense in order to contibute to the understanding of the basis for the expected development.

  11. Plasma Simulation Program

    Energy Technology Data Exchange (ETDEWEB)

    Greenwald, Martin

    2011-10-04

    Many others in the fusion energy and advanced scientific computing communities participated in the development of this plan. The core planning team is grateful for their important contributions. This summary is meant as a quick overview the Fusion Simulation Program's (FSP's) purpose and intentions. There are several additional documents referenced within this one and all are supplemental or flow down from this Program Plan. The overall science goal of the DOE Office of Fusion Energy Sciences (FES) Fusion Simulation Program (FSP) is to develop predictive simulation capability for magnetically confined fusion plasmas at an unprecedented level of integration and fidelity. This will directly support and enable effective U.S. participation in International Thermonuclear Experimental Reactor (ITER) research and the overall mission of delivering practical fusion energy. The FSP will address a rich set of scientific issues together with experimental programs, producing validated integrated physics results. This is very well aligned with the mission of the ITER Organization to coordinate with its members the integrated modeling and control of fusion plasmas, including benchmarking and validation activities. [1]. Initial FSP research will focus on two critical Integrated Science Application (ISA) areas: ISA1, the plasma edge; and ISA2, whole device modeling (WDM) including disruption avoidance. The first of these problems involves the narrow plasma boundary layer and its complex interactions with the plasma core and the surrounding material wall. The second requires development of a computationally tractable, but comprehensive model that describes all equilibrium and dynamic processes at a sufficient level of detail to provide useful prediction of the temporal evolution of fusion plasma experiments. The initial driver for the whole device model will be prediction and avoidance of discharge-terminating disruptions, especially at high performance, which are a

  12. PLASMA DEVICE

    Science.gov (United States)

    Gow, J.D.; Wilcox, J.M.

    1961-12-26

    A device is designed for producing and confining highenergy plasma from which neutrons are generated in copious quantities. A rotating sheath of electrons is established in a radial electric field and axial magnetic field produced within the device. The electron sheath serves as a strong ionizing medium to gas introdueed thereto and also functions as an extremely effective heating mechanism to the resulting plasma. In addition, improved confinement of the plasma is obtained by ring magnetic mirror fields produced at the ends of the device. Such ring mirror fields are defined by the magnetic field lines at the ends of the device diverging radially outward from the axis of the device and thereafter converging at spatial annular surfaces disposed concentrically thereabout. (AFC)

  13. On the use of the plasma in III-V semiconductor processing

    Energy Technology Data Exchange (ETDEWEB)

    Bruno, G.; Capezzuto, P.; Losurdo, M. [C.N.R.-Centro di Studio per la Chimica dei Plasmi Dipartimento di Chimica-Universita di Bari via Orabona, 4-70126 Bari (Italy)

    1996-03-01

    The manufacture of usable devices based on III-V semiconductor materials is a complex process requiring epilayer growth, anisotropic etching, defect passivation, surface oxidation and substrate preparation processes. The combination of plasma based methods with metalorganic chemical vapor deposition (MOCVD) offers some real advantages: {ital in} {ital situ} production and preactivation of PH{sub 3} and sample preparation using H-atom. The detailed understanding and use of the plasma (using mass spectrometry, optical emission spectroscopy, laser reflectance interferometry and spectroscopic ellipsometry) as applied to InP material is discussed. {copyright} {ital 1996 American Institute of Physics.}

  14. Plasma properties

    International Nuclear Information System (INIS)

    Weitzner, H.

    1989-08-01

    A cursory examination of the research activities of the Magneto-Fluid Dynamics Division for the calendar year 1988 shows the effects of the gradual transformation of the group. Although our principal activity, fusion plasma physics research, is unchanged, the work shows closer ties to problems relevant to present experiments than previously. Most notable is the concentrated effort on tokamak equilibrium and transport. We are exploring the implication of turbulence induced transport, resistive MHD effects, neoclassical transport, and possible interpretations of transport based on classical phenomena. In addition, one of our members has chosen to focus on problems of enhanced statistical methods for interpretation of experiments. All of this activity preceded the Tokamak Transport Initiative and reflects our active involvement and concern with the world-wide tokamak program. Since equilibrium and transport are by no means the only theoretical plasma physics problems affecting fusion devices we continue substantial efforts in wave propagation and heating, particle simulation of plasmas, stability theory, enhancement of numerical algorithms, and general plasma physics. We are attempting to develop effective numerical schemes for the Boltzmann equation, adaptive grid methods for MHD, and particle simulation of boundary and antenna effects. Many of these topics reflect our continuing concern to maintain a modest effort in the development of theoretical models and tools for problems of real significance to fusion, but not necessarily of immediate highest priority. We select problems which we expect to become extremely important in the future. Our space plasma physics activities, funded by agencies other than DOE, transfers knowledge learned in fusion plasma physics to another area and conversely stimulates work also relevant to fusion problems

  15. Plasma treatment of crane rails

    Directory of Open Access Journals (Sweden)

    Владислав Олександрович Мазур

    2016-07-01

    Full Text Available Crane operation results in wear and tear of rails and crane wheels. Renovation and efficiency of these details is therefore relevant. Modern technologies of wheels and rails restoration use surfacing or high-frequency currents treatment. Surface treatment with highly concentrated streams of energy- with a laser beam, plasma jet- is a promising direction.. It is proposed to increase the efficiency of crane rails by means of surface plasma treatment. The modes of treatment have been chosen.. Modelling of plasma jet thermal impact on a solid body of complex shape has been made. Plasma hardening regimes that meet the requirements of production have been defined. Structural transformation of the material in the crane rails on plasma treatment has been investigated. It has been concluded that for carbon and low alloy crane steels the plasma exposure zone is characterized by a high degree of hardened structure dispersion and higher hardness as compared to the hardness after high-frequency quenching. As this takes place phase transformations are both shift (in the upper zone of plasma influence and fluctuation (in the lower zone of the plasma. With high-speed plasma heating granular or lamellar pearlite mainly transforms into austenite. The level of service characteristics of hardened steel, which is achieved in this case is determined by the kinetics and completeness of pearlite → austenite transformation. For carbon and low alloy rail steels plasma hardening can replace bulk hardening, hardening by high-frequency currents, or surfacing. The modes for plasma treatment which make it possible to obtain a surface layer with a certain service characteristics have been defined

  16. 25 Years of Self-organized Criticality: Space and Laboratory Plasmas

    Science.gov (United States)

    Sharma, A. Surjalal; Aschwanden, Markus J.; Crosby, Norma B.; Klimas, Alexander J.; Milovanov, Alexander V.; Morales, Laura; Sanchez, Raul; Uritsky, Vadim

    2016-01-01

    Studies of complexity in extended dissipative dynamical systems, in nature and in laboratory, require multiple approaches and the framework of self-organized criticality (SOC) has been used extensively in the studies of such nonequilibrium systems. Plasmas are inherently nonlinear and many ubiquitous features such as multiscale behavior, intermittency and turbulence have been analyzed using SOC concepts. The role of SOC in advancing our understanding of space and laboratory plasmas as nonequilibrium systems is reviewed in this article. The main emphasis is on how SOC and related approaches have provided new insights and models of nonequilibrium plasma phenomena. Among the natural plasmas the magnetosphere, driven by the solar wind, is a prominent example and extensive data from ground-based and space-borne instruments have been used to study phenomena of direct relevance to space weather, viz. geomagnetic storms and substorms. During geomagnetically active periods the magnetosphere is far from equilibrium, due to its internal dynamics and being driven by the turbulent solar wind, and substorms are prominent features of the complex driven system. Studies using solar wind and magnetospheric data have shown both global and multiscale features of substorms. While the global behavior exhibits system-wide changes, the multiscale behavior shows scaling features. Along with the studies based on observational data, analogue models of the magnetosphere have advanced the understanding of space plasmas as well as the role of SOC in natural systems. In laboratory systems, SOC has been used in modeling the plasma behavior in fusion experiments, mainly in tokamaks and stellarators. Tokamaks are the dominant plasma confinement system and modeling based on SOC have provided a complementary approach to the understanding of plasma behavior under fusion conditions. These studies have provided insights into key features of toroidally confined plasmas, e.g., the existence of critical

  17. Electron plasma waves and plasma resonances

    International Nuclear Information System (INIS)

    Franklin, R N; Braithwaite, N St J

    2009-01-01

    In 1929 Tonks and Langmuir predicted of the existence of electron plasma waves in an infinite, uniform plasma. The more realistic laboratory environment of non-uniform and bounded plasmas frustrated early experiments. Meanwhile Landau predicted that electron plasma waves in a uniform collisionless plasma would appear to be damped. Subsequent experimental work verified this and revealed the curious phenomenon of plasma wave echoes. Electron plasma wave theory, extended to finite plasmas, has been confirmed by various experiments. Nonlinear phenomena, such as particle trapping, emerge at large amplitude. The use of electron plasma waves to determine electron density and electron temperature has not proved as convenient as other methods.

  18. Understanding uncertainty

    CERN Document Server

    Lindley, Dennis V

    2013-01-01

    Praise for the First Edition ""...a reference for everyone who is interested in knowing and handling uncertainty.""-Journal of Applied Statistics The critically acclaimed First Edition of Understanding Uncertainty provided a study of uncertainty addressed to scholars in all fields, showing that uncertainty could be measured by probability, and that probability obeyed three basic rules that enabled uncertainty to be handled sensibly in everyday life. These ideas were extended to embrace the scientific method and to show how decisions, containing an uncertain element, could be rationally made.

  19. Plasma diagnostics surface analysis and interactions

    CERN Document Server

    Auciello, Orlando

    2013-01-01

    Plasmas and their interaction with materials have become subjects of major interest because of their importance in modern forefront technologies such as microelectronics, fusion energy, and space. Plasmas are used in microelectronics to process semiconductors (etching of patterns for microcircuits, plasma-induced deposition of thin films, etc.); plasmas produce deleterious erosion effects on surfaces of materials used for fusion devices and spaceships exposed to the low earth environment.Diagnostics of plasmas and materials exposed to them are fundamental to the understanding of the physical a

  20. The Framework of Plasma Physics

    CERN Document Server

    Hazeltine, Richard D

    2004-01-01

    Plasma physics is a necessary part of our understanding of stellar and galactic structure. It determines the magnetospheric environment of the earth and other planets; it forms the research frontier in such areas as nuclear fusion, advanced accelerators, and high power lasers; and its applications to various industrial processes (such as computer chip manufacture) are rapidly increasing. It is thus a subject with a long list of scientific and technological applications. This book provides the scientific background for understanding such applications, but it emphasizes something else: the intrinsic scientific interest of the plasma state. It attempts to develop an understanding of this state, and of plasma behavior, as thoroughly and systematically as possible. The book was written with the graduate student in mind, but most of the material would also fit into an upper-level undergraduate course.