Sample records for understanding complex issues

  1. Understanding the Complexity of Social Issues through Process Drama. (United States)

    O'Mara, Joanne


    Attempts to capture the process of understanding and questioning deforestation through process drama (in which students and teacher work both in and out of role to explore a problem, situation, or theme). Notes that moving topics such as the destruction of a rainforest into process drama introduces complexity into social issues. Considers how…

  2. Supporting Individuals with Autism Spectrum Disorder in Understanding and Coping with Complex Social Emotional Issues (United States)

    Ahlers, Kaitlyn P.; Gabrielsen, Terisa P.; Lewis, Danielle; Brady, Anna M.; Litchford, April


    Core deficits in autism spectrum disorder (ASD) center around social communication and behavior. For those with ASD, these deficits complicate the task of learning how to cope with and manage complex social emotional issues. Although individuals with ASD may receive sufficient academic and basic behavioral support in school settings, supports for…

  3. Improving the understanding and treatment of complex grief: an important issue for psychotraumatology

    Directory of Open Access Journals (Sweden)

    Paul A. Boelen


    Full Text Available In the Netherlands, every year 500,000 people are confronted with the death of a close relative. Many of these people experience little emotional distress. In some, bereavement precipitates severe grief, distress, and dysphoria. A small yet significant minority of bereaved individuals develops persistent and debilitating symptoms of persistent complex bereavement disorder (PCBD (also termed prolonged grief disorder, posttraumatic stress disorder, and depression. Knowledge about early identification of, and preventive care for complex grief has increased. Moreover, in recent years there has been an increase in treatment options for people for whom loss leads to persistent psychological problems. That said, preventive and curative treatments are effective for some, but not all bereaved individuals experiencing distress and dysfunction following loss. This necessitates further research on the development, course, and treatment of various stages of complex grief, including PCBD. Highlights of the article:

  4. Understanding Pregnancy and Birth Issues (United States)

    ... Home Current Issue Past Issues Understanding Pregnancy and Birth Issues Past Issues / Winter 2008 Table of Contents ... about NICHD preeclampsia research in the sidebar.) Preterm Birth Preterm (premature) birth is birth before the baby ...

  5. Understanding nuclear issues

    Energy Technology Data Exchange (ETDEWEB)

    Marx, G. [Department of Atomic Physics, Eoetvoes Univ., Budapest (Hungary)


    In our days technological progress for the benefit of society is slowed down by the fact that common citizens (opinion-forming media reporters, journalists, furthermore elected decision-makers) are underinformed about basic numerical facts concerning harms and benefits of high technology. Here a comparative risk study is presented about smoking, ozone hole, global warming, and ionizing radiation. This approach has turned out to be successful in educating the youth in Hungary; because school-going teenagers do understand numbers. (author)

  6. Understanding nuclear issues

    International Nuclear Information System (INIS)

    Marx, G.


    In our days technological progress for the benefit of society is slowed down by the fact that common citizens (opinion-forming media reporters, journalists, furthermore elected decision-makers) are underinformed about basic numerical facts concerning harms and benefits of high technology. Here a comparative risk study is presented about smoking, ozone hole, global warming, and ionizing radiation. This approach has turned out to be successful in educating the youth in Hungary; because school-going teenagers do understand numbers. (author)

  7. Understanding Supply Networks from Complex Adaptive Systems

    Directory of Open Access Journals (Sweden)

    Jamur Johnas Marchi


    Full Text Available This theoretical paper is based on complex adaptive systems (CAS that integrate dynamic and holistic elements, aiming to discuss supply networks as complex systems and their dynamic and co-evolutionary processes. The CAS approach can give clues to understand the dynamic nature and co-evolution of supply networks because it consists of an approach that incorporates systems and complexity. This paper’s overall contribution is to reinforce the theoretical discussion of studies that have addressed supply chain issues, such as CAS.

  8. Understanding Current Safety Issues for Trajectory Based Operations (United States)

    Feary, Michael; Stewart, Michael


    Increases in procedural complexity were investigated as a possible contributor to flight path deviations in airline operations. Understanding current operational issues and their causes must be embraced to maintain current safety standards while increasing future functionality. ASRS data and expert narratives were used to discover factors relating to pilot deviations. Our investigation pointed to ATC intervention, automation confusion, procedure design, and mixed equipment as primary issues. Future work will need to include objective data and mitigation strategies.

  9. Complexity Issues in Basic Logic

    Czech Academy of Sciences Publication Activity Database

    Aguzzoli, S.; Gerla, B.; Haniková, Zuzana


    Roč. 9, - (2005), s. 919-934 ISSN 1432-7643 R&D Projects: GA MŠk LN00A056 Institutional research plan: CEZ:AV0Z10300504 Keywords : basic fuzzy logic (BL) * computational complexity * functional representation Subject RIV: BA - General Mathematics Impact factor: 0.538, year: 2005

  10. Intertextuality for Handling Complex Environmental Issues (United States)

    Byhring, Anne Kristine; Knain, Erik


    Nowhere is the need for handling complexity more pertinent than in addressing environmental issues. Our study explores students' situated constructs of complexity in unfolding discourses on socio-scientific issues. Students' dialogues in two group-work episodes are analysed in detail, with tools from Systemic Functional Linguistics. We identify…

  11. Special Issue on Ruthenium Complexes

    Directory of Open Access Journals (Sweden)

    Ileana Dragutan


    Full Text Available The organic chemistry of ruthenium has been one of the most vigorously growing research areas over the past decades. Considerable effort has been extended towards the design and application of a broad series of ruthenium complexes, which culminated with the development by Ryoji Noyori (2001 Nobel Prize for Chemistry of chiral ruthenium catalysts for stereoselective hydrogenation reactions [1], and the discovery by Robert H. Grubbs (2005 Nobel Prize for Chemistry of well-defined ruthenium– benzylidene catalysts for olefin metathesis [2] [...

  12. Science Communication for the Public Understanding of Nuclear Issues

    International Nuclear Information System (INIS)

    Cho, Seongkyung


    Uncertainty, stigma, risk perception, and value judgment represent characteristics of nuclear issues in the public arena. Nuclear issue, in the public arena, is a kind of risk rather than technology that we are willing to use for good purpose. There are uncertainty, stigma, risk perception, and value judgment as characteristics of nuclear. The notion of the public, here is of active, sensitive, and sensible citizens, with power and influence. The public understands nuclear issues less through direct experience or education than through the filter of mass media. Trust has been a key issue on public understanding of nuclear issues. Trust belongs to human. The public understanding process includes perception, interpretation, and evaluation. Therefore, science communication is needed for public understanding. Unfortunately, science communication is rarely performed well, nowadays, There are three important actors-the public, experts, and media. Effective science communication means finding comprehensible ways of presenting opaque and complex nuclear issues. It makes new and strong demands on experts. In order to meet that requirement, experts should fulfill their duty about developing nuclear technology for good purpose, understand the public before expecting the public to understand nuclear issues, accept the unique culture of the media process, take the responsibility for any consequence which nuclear technologies give rise to, communicate with an access route based on sensibility and rationality, have a flexible angle in the science communication process, get creative leadership for the communication process with deliberation and disagreement, make efficient use of various science technologies for science communication. We should try to proceed with patience, because science communication makes for a more credible society

  13. Understanding Game-Based Learning Cultures: Introduction to Special Issue (United States)

    Engerman, Jason A.; Carr-Chellman, Alison


    This special issue expands our understanding of teaching and learning through video game play, with specific attention to culture. The issue gives insight into the ways educators, researchers, and developers should be discussing and designing for impactful learner-centered game-based learning experiences. The issue features forward-thinking…

  14. Understanding Complex Construction Systems Through Modularity

    DEFF Research Database (Denmark)

    Jensen, Tor Clarke; Bekdik, Baris; Thuesen, Christian


    finds that the main driver of complexity is the fragmentation of the design and production, which causes the production modules to construct and install new product types and variants for each project as the designers are swapped for every project. The many interfaces are characteristics of an integral......This paper develops a framework for understanding complexity in construction projects by combining theories of complexity management and modularization. The framework incorporates three dimensions of product, process, and organizational modularity with the case of gypsum wall elements. The analysis...... system, rather than a modular, although the industry forces modular organizational structures. This creates a high complexity degree caused by the non-alignment of building parts and organizations and the frequent swapping of modules....

  15. Ethnosocial issues within the covers of "Knowledge. Understanding. Skill” Journal

    Directory of Open Access Journals (Sweden)

    Elena A. Erokhina


    Full Text Available Article reviews the most interesting publications regarding the issues of actual ethnosocial processes published in the well-known Russian journal "Knowledge. Understanding, Skill” which marks its 10th anniversary this year.

  16. Introduction to focus issue: mesoscales in complex networks. (United States)

    Almendral, Juan A; Criado, Regino; Leyva, Inmaculada; Buldú, Javier M; Sendiña-Nadal, Irene


    Although the functioning of real complex networks is greatly determined by modularity, the majority of articles have focused, until recently, on either their local scale structure or their macroscopical properties. However, neither of these descriptions can adequately describe the important features that complex networks exhibit due to their organization in modules. This Focus Issue precisely presents the state of the art on the study of complex networks at that intermediate level. The reader will find out why this mesoscale level has become an important topic of research through the latest advances carried out to improve our understanding of the dynamical behavior of modular networks. The contributions presented here have been chosen to cover, from different viewpoints, the many open questions in the field as different aspects of community definition and detection algorithms, moduli overlapping, dynamics on modular networks, interplay between scales, and applications to biological, social, and technological fields.

  17. Dependency visualization for complex system understanding

    Energy Technology Data Exchange (ETDEWEB)

    Smart, J. Allison Cory [Univ. of California, Davis, CA (United States)


    With the volume of software in production use dramatically increasing, the importance of software maintenance has become strikingly apparent. Techniques now sought and developed for reverse engineering and design extraction and recovery. At present, numerous commercial products and research tools exist which are capable of visualizing a variety of programming languages and software constructs. The list of new tools and services continues to grow rapidly. Although the scope of the existing commercial and academic product set is quite broad, these tools still share a common underlying problem. The ability of each tool to visually organize object representations is increasingly impaired as the number of components and component dependencies within systems increases. Regardless of how objects are defined, complex ``spaghetti`` networks result in nearly all large system cases. While this problem is immediately apparent in modem systems analysis involving large software implementations, it is not new. As will be discussed in Chapter 2, related problems involving the theory of graphs were identified long ago. This important theoretical foundation provides a useful vehicle for representing and analyzing complex system structures. While the utility of directed graph based concepts in software tool design has been demonstrated in literature, these tools still lack the capabilities necessary for large system comprehension. This foundation must therefore be expanded with new organizational and visualization constructs necessary to meet this challenge. This dissertation addresses this need by constructing a conceptual model and a set of methods for interactively exploring, organizing, and understanding the structure of complex software systems.

  18. Listening, understanding and interpreting: reflections on complexity. (United States)

    Lichtenberg, J D


    Beginning with the premise that a contemporary approach to analytic exchanges has become far more complex and multi-faceted than in earlier times, the author addresses listening, understanding and interpreting. The opening section presents the basis and utility of a proposed theory of five motivational systems and identifies the need for a shift from conceptualising 'structures' to systems. The nature of communication during analysis is considered from several standpoints including listening for needs and intentions, the place of theory as a background to listening, an optimal state for analysand and analyst, and the significance of the distinction between inner monologue and spoken discourse. Differing views of free association and narrative, especially questions arising from findings of the 'adult attachment interview', are discussed. The patient's sensitivity to the presence and influence of the analyst and the analyst's recognition of non-verbal as well as verbal communications completes this section. In the final section a brief clinical example is presented to introduce a differentiated depiction of the variety of interventions that analysts employ. Throughout the paper, the author presents his view of listening, understanding and interpreting in dialectic contrast with the many other perspectives held by analysts in this period of theoretical pluralism.

  19. An understanding of environmental concepts and issues among ...

    African Journals Online (AJOL)

    The major aim of this study is to assess the knowledge and understanding of Grade 10-12 students about selected environmental concepts and issues such as population, ozone layer, green house effect, and acid rain. Another aim of this study is to find out whether there is any difference between the knowledge and ...

  20. an understanding of environmental concepts and issues among

    African Journals Online (AJOL)

    environmental knowledge, attitudes and concern are also conflicting. As there is disagreement about the direction of relationships between different variables, therefore, there is a need to investigate the understanding of environmental concepts and issues among Grade 10-12 students from rural and urban schools.

  1. Understanding the complex interplay between tourism, disability and environmental contexts. (United States)

    Packer, Tanya L; McKercher, Bob; Yau, Matthew K


    To explore and describe the complex issues and factors related to participation in tourism as perceived by people with disabilities in Hong Kong. Naturalistic inquiry using key informant interviews and focus groups with 86 people with disabilities. Interviews were transcribed, translated and coded to develop themes and relationships. Triangulation of three investigators from different backgrounds occurred. The Process of Becoming Travel Active emerged as a six-stage process, intricately related to the personal/disability context and the environmental/travel context. Personal and environmental factors contribute to the six-stage model explaining the complex interplay between tourism, disability and environmental context. Understanding the complexity provides insight into ways to increase active participation in tourism. Health, tourism and disability sectors have a role to play in the development of accessible tourism.

  2. Advancing Our Understanding of Cross-Cultural Issues in Consumer Science and Consumer Psychology

    NARCIS (Netherlands)

    van Herk, H.; Torelli, Carlos J.; van Herk, Hester; Torelli, Carlos J.


    Globalization has resulted in a more complex marketplace. Growing multi-culturalism of consumer markets and increased global competition are pushing marketing scholars to better understand cross-cultural issues in consumer science and consumer psychology. The chapters in this book cover the field to

  3. Complexities of Parental Understanding of Phenylketonuria (United States)

    Sibinga, Maarten S.; Friedman, C. Jack


    Parental understanding of PKU, investigated through a questionnaire, was evaluated as to completeness and with respect to distortion. Education of parents was found to be unrelated to their understanding or tendency to distort. Effectiveness of the pediatrician's communication with parents is discussed. (Author/KW)

  4. Understanding the Etiology of Tuberous Sclerosis Complex (United States)


    of life as infantile spasms that are unresponsive to conventional anti-epileptic drug therapies (Curatolo et al., 2001; Holmes and Stafstrom, 2007... Infantile spasms in tuberous sclerosis complex. Brain Dev 23:502-507. DiMario FJ, Jr. (2004) Brain abnormalities in tuberous sclerosis complex. J...on chromosome 16. Cell, 75, 1305–1315. 3. Curatolo, P., Seri, S., Verdecchia, M. and Bombardieri, R. (2001) Infantile spasms in tuberous sclerosis

  5. Maintaining Program Understanding - Issues, Tools, and Future Directions

    DEFF Research Database (Denmark)

    Vestdam, Thomas; Nørmark, Kurt


    documentation tools are reviewed. The tools are selected on basis of relevance for the key documentation issues, and relative to the common attention and interest of the particular tool in the documentation communities. As a conclusion of the paper, and as a final contribution, a number of future directions....... One approach to maintaining program understanding is to document decisions and rationales behind a program as informal textual explanations---internal documentation. The starting point of this paper is a particular paradigm for program documentation called Elucidative Programming. As the first...... the distance between the documentation and the program. Documentation occasions are points in time for capturing and formulating the understanding of the program. During the years a large number of documentation tools have been developed. As the second contribution of the paper, a number of contemporary...

  6. School Phobia: Understanding a Complex Behavioural Response (United States)

    Chitiyo, Morgan; Wheeler, John J.


    School phobia affects about 5% of the school-age population. If left untreated, school phobia can have devastating long-term consequences in children challenged by this condition. Various treatment approaches have been used to explore this complex behavioural response, major among them being the psychoanalytic, psychodynamic, pharmacological and…

  7. Understanding the Complexity of a Rising China (United States)


    at the macro-level are determined by security interests derived from anarchy.48 From this mindset , Waltz attempted to draw on elements of complexity...artificialities. The restrictions prevented the expansion of the PRC multinational corporations, as it was more difficult for Chinese entrepreneurs to receive...unknowable.” This does not mean there is no point in planning. It simply establishes a mindset that there are no universal truths or solution sets. All

  8. Understanding the Complexity of Teacher Reflection in Action Research (United States)

    Luttenberg, Johan; Meijer, Paulien; Oolbekkink-Marchand, Helma


    Reflection in action research is a complex matter, as is action research itself. In recent years, complexity science has regularly been called upon in order to more thoroughly understand the complexity of action research. The present article investigates the benefits that complexity science may yield for reflection in action research. This article…

  9. Land, power and conflict in Afghanistan: seeking to understand complexity

    Directory of Open Access Journals (Sweden)

    Adam Pain


    Full Text Available This paper explores the diverse links between land and power under conditions of conflict in Afghanistan, taking into account the complexities of Afghan society. These complexities are structured around interconnecting informal institutions and personalised relationships, culturally specific, diverse and shifting patterns of social relations, and spatially specific patterns of land ownership inequalities. The paper draws on a decade of empirical fieldwork in Afghanistan and recent work on livelihood trajectories and the opium economy. An understanding of the evolution of land ownership and access issues needs to be associated with an appreciation of diverse and potentially contradictory long-term drivers of change in the rural economy. The first of these long-term drivers of change relates to the effects of conflict, not only on land but also of water access under conditions of an increasingly scarce water supply. The second driver relates both to the roles played by village elites and to the structural contrasts between villages located in the mountains and in the plains, with the latter displaying major inequalities in land ownership. The third driver relates to the declining economic role of land in rural livelihoods, given long-term agrarian change and falling farm sizes. An understanding of history is fundamental to explaining these phenomena. How such conflicts play out, and which social groups or individuals they involve, also depend to a large degree on spatial positioning.

  10. Climate. For a successful change. Volume 1: How to commit one's territory in an adaptation approach. Volume 2: How to implement a territorial project which integrates adaptation. Volume 3: How to understand the complexity of climate change - Scientific issues

    International Nuclear Information System (INIS)


    The first volume presents the climate issue as a world issue as well as a local issue (historic context of adaptation to climate change effects, legal obligation for local communities, indicators of direct and indirect effects of climate change, economic impacts), and presents adaptation as a way of action at a local level (definition of a strategy, articulation between works on greenhouse gas emissions and those on adaptation, actions to be implemented, action follow-up and adjustment). The second volume describes how to communicate and talk about climate change, and more specifically about the above-mentioned issues (reality of climate change, indirect and direct effects, obligations and responsibilities for local communities, economic impacts). It addresses the issue of climate change in the Rhone-Alpes region: adaptation within the regional scheme on climate, air and energy (SRCAE), role of local communities. It presents an action methodology: to inform and organise, to prepare the mobilisation of actors, to prepare the territory vulnerability diagnosis, to define the adaptation strategy, and to implement, follow-up and assess the action. The third volume proposes a set of sheets containing scientific information and data related to climate change: factors of climate variability, current global warming, greenhouse gases and aerosols, physical-chemical principles involved in greenhouse effect, carbon sinks and carbon sources, effects of land assignment and agriculture, combined effects of mankind actions on the atmosphere, climate change and oceans, climate change and cryo-sphere, climate change and biodiversity, extreme meteorological and climate events and their consequences

  11. Understanding complex interactions using social network analysis. (United States)

    Pow, Janette; Gayen, Kaberi; Elliott, Lawrie; Raeside, Robert


    The aim of this paper is to raise the awareness of social network analysis as a method to facilitate research in nursing research. The application of social network analysis in assessing network properties has allowed greater insight to be gained in many areas including sociology, politics, business organisation and health care. However, the use of social networks in nursing has not received sufficient attention. Review of literature and illustration of the application of the method of social network analysis using research examples. First, the value of social networks will be discussed. Then by using illustrative examples, the value of social network analysis to nursing will be demonstrated. The method of social network analysis is found to give greater insights into social situations involving interactions between individuals and has particular application to the study of interactions between nurses and between nurses and patients and other actors. Social networks are systems in which people interact. Two quantitative techniques help our understanding of these networks. The first is visualisation of the network. The second is centrality. Individuals with high centrality are key communicators in a network. Applying social network analysis to nursing provides a simple method that helps gain an understanding of human interaction and how this might influence various health outcomes. It allows influential individuals (actors) to be identified. Their influence on the formation of social norms and communication can determine the extent to which new interventions or ways of thinking are accepted by a group. Thus, working with key individuals in a network could be critical to the success and sustainability of an intervention. Social network analysis can also help to assess the effectiveness of such interventions for the recipient and the service provider. © 2012 Blackwell Publishing Ltd.

  12. The Dynamics of Hope and Motivations in Groups Working on Complex Societal Issues

    Directory of Open Access Journals (Sweden)

    Pia Andersson


    Full Text Available This paper reports results from a study of how participants’ sense of personal hope and motivation was affected by a facilitated process in which four groups of people worked on different complex social issues. The group interventions were designed to scaffold increased understanding of the complexity of the chosen issue. A method called The Integral Process for Working on Complex Issues was used in all of the groups. Issues addressed in the four groups were: neighborhood deterioration, lack of community engagement, the need for better strategies for communication between rescue service actors in critical life-and-death situations, and transition to a more environmentally sustainable city. The study investigated the participants’ self-reported changes in their levels of hope regarding the possibility of achieving positive results on the selected issue, and changes in their motivation to engage in work to that end. The data were gathered through interviews with individual group participants before and after the group process. The sessions supported group members to develop more awareness of the complexity of the issues, and to develop strategies for action. The study indicates that the discovery of new potential pathways to manage an issue, through a more comprehensive understanding of the complexity involved, was a key factor influencing levels of hope and motivation. Reports from participants showed that when the participants formulated concrete actions that made sense to them, then “particularized hope” emerged, as well as motivation to continue to engage. Thus, increased levels of hope about a delimited part of the issue were reported, while in some cases, participants reported having less hope about the issue complex as a whole.

  13. Simple, complex and hyper-complex understanding - enhanced sensitivity in observation of information

    DEFF Research Database (Denmark)

    Bering Keiding, Tina

    enhanced transparency in selection of understanding as well as enhanced sensitivity and definition in dept. The contribution suggest that we distinguish between three types of understanding; simple, complex and hyper-complex understanding. Simple understanding is the simultaneous selection of understanding......-order observation. Hyper-complex, or third-order observation, observes conditions for indication; that is conditions for actualization of the specific form of the difference constructed through second-order observation. The three types are partly deduced from Luhmanns concept of understanding, partly generated...

  14. Understanding Learner Agency as a Complex Dynamic System (United States)

    Mercer, Sarah


    This paper attempts to contribute to a fuller understanding of the nature of language learner agency by considering it as a complex dynamic system. The purpose of the study was to explore detailed situated data to examine to what extent it is feasible to view learner agency through the lens of complexity theory. Data were generated through a…

  15. Ecosystemic Complexity Theory of Conflict: Understanding the Fog of Conflict (United States)

    Brack, Greg; Lassiter, Pamela S.; Hill, Michele B.; Moore, Sarah A.


    Counselors often engage in conflict mediation in professional practice. A model for understanding the complex and subtle nature of conflict resolution is presented. The ecosystemic complexity theory of conflict is offered to assist practitioners in navigating the fog of conflict. Theoretical assumptions are discussed with implications for clinical…

  16. Selected Topics on Managing Complexity and Information Systems Engineering: Editorial Introduction to Issue 8 of CSIMQ

    Directory of Open Access Journals (Sweden)

    Peter Forbrig


    Full Text Available Business process models greatly contribute to analyze and understand the activities of enterprises. However, it is still a challenge to cope with the complexity of systems specifications and their requirements. This issue of the journal of Complex Systems Informatics and Modeling (CSIMQ presents papers that discuss topics on managing complexity and information systems engineering. The papers are extended versions of selected papers from the workshop on Continuous Requirements Engineering held at the requirements engineering conference REFSQ 2016 in Gothenburg, the workshop on Managed Complexity held at the business informatics conference BIR 2016 in Prague, and the CAiSE 2016 Forum held in Ljubljana.

  17. Understanding and Developing Controversial Issues in College Courses. (United States)

    Payne, Brian K.; Gainey, Randy R.


    Discusses common controversial issues in different college disciplines, such as the death penalty and drug legalization. Also suggests useful methods for encouraging enlightening discussions, such as verbal and physical cues, student-centered activities, and text selection. (SLD)

  18. Understanding complex urban systems multidisciplinary approaches to modeling

    CERN Document Server

    Gurr, Jens; Schmidt, J


    Understanding Complex Urban Systems takes as its point of departure the insight that the challenges of global urbanization and the complexity of urban systems cannot be understood – let alone ‘managed’ – by sectoral and disciplinary approaches alone. But while there has recently been significant progress in broadening and refining the methodologies for the quantitative modeling of complex urban systems, in deepening the theoretical understanding of cities as complex systems, or in illuminating the implications for urban planning, there is still a lack of well-founded conceptual thinking on the methodological foundations and the strategies of modeling urban complexity across the disciplines. Bringing together experts from the fields of urban and spatial planning, ecology, urban geography, real estate analysis, organizational cybernetics, stochastic optimization, and literary studies, as well as specialists in various systems approaches and in transdisciplinary methodologies of urban analysis, the volum...

  19. Maintaining Program Understanding - Issues, Tools, and Future Directions

    DEFF Research Database (Denmark)

    Vestdam, Thomas; Nørmark, Kurt


    The understanding of a program is a key aspect of software development. The understanding is a prerequisite for the initial development efforts. This paper is concerned with the challenge of maintaining the program understanding with the purpose of supporting later phases in the program life time....... One approach to maintaining program understanding is to document decisions and rationales behind a program as informal textual explanations---internal documentation. The starting point of this paper is a particular paradigm for program documentation called Elucidative Programming. As the first...

  20. Health care labor relations law--understanding the issues. (United States)

    Pepe, S P; Keith, C L


    The 1974 amendments to the Labor Management Relations Act have created new problems of statutory interpretation in the rapidly evolving area of health care labor law. By including nonprofit hospitals under the auspices of the Act, the amendments have opened up a new area for unionization and have given rise to questions concerning the types of bargaining units that are appropriate in health care facilities. In the following article, the authors discuss these questions and other current issues in health care labor relations law. The issues include the determination of relevant bargaining units, the status of state nursing associations as labor organizations, and the ten-day strike notice requirement of the Labor Management Relations Act.

  1. Understanding food security issues in remote Western Australian Indigenous communities. (United States)

    Pollard, Christina M; Nyaradi, Anett; Lester, Matthew; Sauer, Kay


    Food insecurity in remote Western Australian (WA) Indigenous communities. This study explored remote community store managers' views on issues related to improving food security in order to inform health policy. A census of all remote WA Indigenous community store managers was conducted in 2010. Telephone interviews sought managers' perceptions of community food insecurity, problems with their store, and potential policy options for improving the supply, accessibility, affordability and consumption of nutritious foods. Descriptive analyses were conducted using SPSS for Windows version 17.0. Managers stated that freight costs and irregular deliveries contributed to high prices and a limited range of foods. Poor store infrastructure, compromised cold chain logistics, and commonly occurring power outages affected food quality. Half of the managers said there was hunger in their community because people did not have enough money to buy food. The role of nutritionists beyond a clinical and educational role was not understood. Food security interventions in remote communities need to take into consideration issues such as freight costs, transport and low demand for nutritious foods. Store managers provide important local knowledge regarding the development and implementation of food security interventions. SO WHAT? Agencies acting to address the issue of food insecurity in remote WA Indigenous communities should heed the advice of community store managers that high food prices, poor quality and limited availability are mainly due to transport inefficiencies and freight costs. Improving healthy food affordability in communities where high unemployment and low household income abound is fundamental to improving food security, yet presents a significant challenge.

  2. Selected Topics on Complex Systems Informatics: Editorial Introduction to Issue 12 of CSIMQ

    Directory of Open Access Journals (Sweden)

    Kurt Sandkuhl


    Full Text Available Modeling is an important contribution to dealing with complexity in development and engineering processes. A model is a generalized representation of a piece of reality, with only those real‐world properties included which are relevant to the purpose of modelling. Models don’t remove the complexity of the real world but help to understand it and to design and develop solutions. All articles in this issue are in some respect concerned with models or modelling.The articles in this issue also reflect recent trends in industry and society, such as digitization and industry 4.0, and show that these trends will not necessarily reduce complexity in systems but rather require the combination of proven approaches, such as modelling, and new methods for managing this complexity.

  3. Issues and Solutions of International Understanding Education in China (United States)

    Qin, Li


    School in China has actively implemented International Understanding Education to foster a cosmopolitan perspective. The educational principle is to respect people of various socio-cultural backgrounds through comparing China's culture with that of other countries. However, my survey revealed that such education in practice is limited to…

  4. An Inquiry into the Issue of Understanding and Practicing ...

    African Journals Online (AJOL)

    Democratic election which ought to be the hallmark of democracy has suffered so much in Nigeria. Lack of proper understanding of what it means to have democracy has been one of the major problems that plague our state Nigeria's experience in governance and politics since independence has been a struggle. As the ...

  5. Understanding Global / Local Cultural Leadership : Issues and Methods

    NARCIS (Netherlands)

    Kolsteeg, Johan


    Cultural leaders sail between the Scylla and Charibdis of aggregated trans- and supranational cultural-political discourses and the cultural needs of local communities. How do these dynamics influence the work of cultural leaders? How can we understand the work of cultural leaders to connect

  6. Understanding complex systems: lessons from Auzoux's and von ...

    Indian Academy of Sciences (India)


    Dec 9, 2009 ... Animal and human anatomy is among the most complex systems known, and suitable teaching methods have been of great importance in the progress of knowledge. Examining the human body is part of the process by which medical students come to understand living forms. However, the need to ...

  7. Hanford tank clean up: A guide to understanding the technical issues

    Energy Technology Data Exchange (ETDEWEB)

    Gephart, R.E.; Lundgren, R.E.


    One of the most difficult technical challenges in cleaning up the US Department of Energy`s (DOE) Hanford Site in southeast Washington State will be to process the radioactive and chemically complex waste found in the Site`s 177 underground storage tanks. Solid, liquid, and sludge-like wastes are contained in 149 single- and 28 double-shelled steel tanks. These wastes contain about one half of the curies of radioactivity and mass of hazardous chemicals found on the Hanford Site. Therefore, Hanford cleanup means tank cleanup. Safely removing the waste from the tanks, separating radioactive elements from inert chemicals, and creating a final waste form for disposal will require the use of our nation`s best available technology coupled with scientific advances, and an extraordinary commitment by all involved. The purpose of this guide is to inform the reader about critical issues facing tank cleanup. It is written as an information resource for the general reader as well as the technically trained person wanting to gain a basic understanding about the waste in Hanford`s tanks -- how the waste was created, what is in the waste, how it is stored, and what are the key technical issues facing tank cleanup. Access to information is key to better understanding the issues and more knowledgeably participating in cleanup decisions. This guide provides such information without promoting a given cleanup approach or technology use.

  8. Hanford tank clean up: A guide to understanding the technical issues

    International Nuclear Information System (INIS)

    Gephart, R.E.; Lundgren, R.E.


    One of the most difficult technical challenges in cleaning up the US Department of Energy's (DOE) Hanford Site in southeast Washington State will be to process the radioactive and chemically complex waste found in the Site's 177 underground storage tanks. Solid, liquid, and sludge-like wastes are contained in 149 single- and 28 double-shelled steel tanks. These wastes contain about one half of the curies of radioactivity and mass of hazardous chemicals found on the Hanford Site. Therefore, Hanford cleanup means tank cleanup. Safely removing the waste from the tanks, separating radioactive elements from inert chemicals, and creating a final waste form for disposal will require the use of our nation's best available technology coupled with scientific advances, and an extraordinary commitment by all involved. The purpose of this guide is to inform the reader about critical issues facing tank cleanup. It is written as an information resource for the general reader as well as the technically trained person wanting to gain a basic understanding about the waste in Hanford's tanks -- how the waste was created, what is in the waste, how it is stored, and what are the key technical issues facing tank cleanup. Access to information is key to better understanding the issues and more knowledgeably participating in cleanup decisions. This guide provides such information without promoting a given cleanup approach or technology use

  9. Understanding complex urban systems integrating multidisciplinary data in urban models

    CERN Document Server

    Gebetsroither-Geringer, Ernst; Atun, Funda; Werner, Liss


    This book is devoted to the modeling and understanding of complex urban systems. This second volume of Understanding Complex Urban Systems focuses on the challenges of the modeling tools, concerning, e.g., the quality and quantity of data and the selection of an appropriate modeling approach. It is meant to support urban decision-makers—including municipal politicians, spatial planners, and citizen groups—in choosing an appropriate modeling approach for their particular modeling requirements. The contributors to this volume are from different disciplines, but all share the same goal: optimizing the representation of complex urban systems. They present and discuss a variety of approaches for dealing with data-availability problems and finding appropriate modeling approaches—and not only in terms of computer modeling. The selection of articles featured in this volume reflect a broad variety of new and established modeling approaches such as: - An argument for using Big Data methods in conjunction with Age...

  10. Increasing process understanding by analyzing complex interactions in experimental data

    DEFF Research Database (Denmark)

    Naelapaa, Kaisa; Allesø, Morten; Kristensen, Henning Gjelstrup


    There is a recognized need for new approaches to understand unit operations with pharmaceutical relevance. A method for analyzing complex interactions in experimental data is introduced. Higher-order interactions do exist between process parameters, which complicate the interpretation...... understanding of a coating process. It was possible to model the response, that is, the amount of drug released, using both mentioned techniques. However, the ANOVAmodel was difficult to interpret as several interactions between process parameters existed. In contrast to ANOVA, GEMANOVA is especially suited...... for modeling complex interactions and making easily understandable models of these. GEMANOVA modeling allowed a simple visualization of the entire experimental space. Furthermore, information was obtained on how relative changes in the settings of process parameters influence the film quality and thereby drug...

  11. A Dialogue About Race and Ethnicity in Education: Struggling To Understand Issues in Cross-Cultural Leadership. (United States)

    Shields, Carolyn M.; Larocque, Linda J.; Oberg, Steven Lynn


    A dialogic approach explores some of the complex issues related to race and ethnicity to identify implications for more effective cross-cultural leadership in diverse schools. Revisited field notes, as well as data from interviews and surveys from various research projects, provide the background about the difficulties of understanding race and…

  12. Introduction to Focus Issue: Complex network perspectives on flow systems. (United States)

    Donner, Reik V; Hernández-García, Emilio; Ser-Giacomi, Enrico


    During the last few years, complex network approaches have demonstrated their great potentials as versatile tools for exploring the structural as well as dynamical properties of dynamical systems from a variety of different fields. Among others, recent successful examples include (i) functional (correlation) network approaches to infer hidden statistical interrelationships between macroscopic regions of the human brain or the Earth's climate system, (ii) Lagrangian flow networks allowing to trace dynamically relevant fluid-flow structures in atmosphere, ocean or, more general, the phase space of complex systems, and (iii) time series networks unveiling fundamental organization principles of dynamical systems. In this spirit, complex network approaches have proven useful for data-driven learning of dynamical processes (like those acting within and between sub-components of the Earth's climate system) that are hidden to other analysis techniques. This Focus Issue presents a collection of contributions addressing the description of flows and associated transport processes from the network point of view and its relationship to other approaches which deal with fluid transport and mixing and/or use complex network techniques.

  13. Understanding and education of nuclear power development issues in China

    International Nuclear Information System (INIS)

    Zhang Jing


    This paper describes the introduction of nuclear power to China; the understanding of nuclear power in China, education of nuclear power among chinese people. Through such efforts of The Chinese Nuclear Association the Chinese people already have the basic knowledge and support the nuclear power in general. But there are about fifty percent of people who do not know the nuclear power stations in China and thirty-six percent who do not know the benefit of nuclear power because of the vast and different education level in some undeveloped rural areas where the education can not reach

  14. Membrane transporters and drought resistance – a complex issue

    Directory of Open Access Journals (Sweden)

    Karolina Maria Jarzyniak


    Full Text Available Land plants have evolved complex adaptation strategies to survive changes in water status in the environment. Understanding the molecular nature of such adaptive changes allows the development of rapid innovations to improve crop performance. Plant membrane transport systems play a significant role when adjusting to water scarcity. Here we put proteins participating in transmembrane allocations of various molecules in the context of stomatal, cuticular and root responses, representing a part of the drought resistance strategy. Their role in the transport of signaling molecules, ions or osmolytes is summarized and the challenge of the forthcoming research, resulting from the recent discoveries, is highlighted.

  15. Understanding Decision Making through Complexity in Professional Networks

    Directory of Open Access Journals (Sweden)

    Kon Shing Kenneth Chung


    Full Text Available The attitudes of general practitioners (GP play an influential role in their decision making about patient treatment and care. Considering the GP-patient encounter as a complex system, the interactions between the GP and their personal network of peers give rise to “aggregate complexity,” which in turn influences the GP’s decisions about patient treatment. This study models aggregate complexity and its influence in decision making in primary care through the use of social network metrics. Professional network and attitudinal data on decision making responsibility from 107 rural GPs were analysed. Social network measures of “density” and “inclusiveness” were used for computing the “interrelatedness” of components within such a “complex system.” The “number of components” and “degree of interrelatedness” were used to determine the complexity profiles, which was then used to associate with responsibility in decision making for each GP. GPs in simple profiles (i.e., with low components and interactions in contrast to those in nonsimple profiles, indicate a higher responsibility for the decisions they make in medical care. This study suggests that social networks-based complexity profiles are useful for understanding decision making in primary care as it accounts for the role of influence through the professional networks of GPs.

  16. Building dialogue on complex conservation issues in a conference setting. (United States)

    Rock, Jenny; Sparrow, Andrew; Wass, Rob; Moller, Henrik


    Dialogue about complex science and society issues is important for contemporary conservation agendas. Conferences provide an appropriate space for such dialogue, but despite its recognized worth, best practices for facilitating active dialogue are still being explored. Face-to-face (FTF) and computer-mediated communication (CMC) are two approaches to facilitating dialogue that have different strengths. We assessed the use of these approaches to create dialogue on cultural perspectives of conservation and biodiversity at a national ecology conference. In particular, we aimed to evaluate their potential to enhance dialogue through their integrated application. We used an interactive blog to generate CMC on participant-sourced issues and to prime subsequent discussion in an FTF conference workshop. The quantity and quality of both CMC and FTF discussion indicated that both approaches were effective in building dialogue. Prior to the conference the blog averaged 126 views per day, and 44 different authors contributed a total of 127 comments. Twenty-five participants subsequently participated in active FTF discussion during a 3-h workshop. Postconference surveys confirmed that CMC had developed participants' thinking and deepened FTF dialogue; 88% indicated specifically that CMC helped facilitate the FTF discussion. A further 83% of respondents concluded that preliminary blog discussion would be useful for facilitating dialogue at future conferences. © 2014 Society for Conservation Biology.

  17. Disaster forensics understanding root cause and complex causality

    CERN Document Server


    This book aims to uncover the root causes of natural and man-made disasters by going beyond the typical reports and case studies conducted post-disaster. It opens the black box of disasters by presenting ‘forensic analysis approaches’ to disasters, thereby revealing the complex causality that characterizes them and explaining how and why hazards do, or do not, become disasters. This yields ‘systemic’ strategies for managing disasters. Recently the global threat landscape has seen the emergence of high impact, low probability events. Events like Hurricane Katrina, the Great Japan Earthquake and tsunami, Hurricane Sandy, Super Typhoon Haiyan, global terrorist activities have become the new norm. Extreme events challenge our understanding regarding the interdependencies and complexity of the disaster aetiology and are often referred to as Black Swans. Between 2002 and 2011, there were 4130 disasters recorded that resulted from natural hazards around the world. In these, 1,117,527 people perished and a mi...

  18. Complexity and simplification in understanding recruitment in benthic populations

    KAUST Repository

    Pineda, Jesús


    Research of complex systems and problems, entities with many dependencies, is often reductionist. The reductionist approach splits systems or problems into different components, and then addresses these components one by one. This approach has been used in the study of recruitment and population dynamics of marine benthic (bottom-dwelling) species. Another approach examines benthic population dynamics by looking at a small set of processes. This approach is statistical or model-oriented. Simplified approaches identify "macroecological" patterns or attempt to identify and model the essential, "first-order" elements of the system. The complexity of the recruitment and population dynamics problems stems from the number of processes that can potentially influence benthic populations, including (1) larval pool dynamics, (2) larval transport, (3) settlement, and (4) post-settlement biotic and abiotic processes, and larval production. Moreover, these processes are non-linear, some interact, and they may operate on disparate scales. This contribution discusses reductionist and simplified approaches to study benthic recruitment and population dynamics of bottom-dwelling marine invertebrates. We first address complexity in two processes known to influence recruitment, larval transport, and post-settlement survival to reproduction, and discuss the difficulty in understanding recruitment by looking at relevant processes individually and in isolation. We then address the simplified approach, which reduces the number of processes and makes the problem manageable. We discuss how simplifications and "broad-brush first-order approaches" may muddle our understanding of recruitment. Lack of empirical determination of the fundamental processes often results in mistaken inferences, and processes and parameters used in some models can bias our view of processes influencing recruitment. We conclude with a discussion on how to reconcile complex and simplified approaches. Although it

  19. "Understanding Adam" multiple reciprocal translocations: complex case presentation. (United States)

    Linder, Carie E; Lu, Xianglan; Kim, Young Mi; Li, Shibo; Pineda, Jose


    This article presents a case review of a newborn diagnosed with a complex chromosomal rearrangement, as demonstrated through a painted chromosomal analysis. This infant presented with multiple dysmorphology including cutis aplasia, multiple ocular malformations, bilateral cleft lip and palate, and postnatal hydrocephaly. A chromosomal analysis revealed multiple-ways, balanced translocation involving chromosomes 3, 4, 6, 8, and 9. This case study provides a unique opportunity to, in retrospect, trace each malformation exploring the pathophysiology, etiology, and correlating origin with chromosomal variation. Careful review of this case, enhanced by the visually augmented representation of each translocation, will increase understanding of chromosomal anomalies and their implications in embryological development and clinical presentation.

  20. Understanding Parkinson Disease: A Complex and Multifaceted Illness. (United States)

    Gopalakrishna, Apoorva; Alexander, Sheila A


    Parkinson disease is an incredibly complex and multifaceted illness affecting millions of people in the United States. Parkinson disease is characterized by progressive dopaminergic neuronal dysfunction and loss, leading to debilitating motor, cognitive, and behavioral symptoms. Parkinson disease is an enigmatic illness that is still extensively researched today to search for a better understanding of the disease, develop therapeutic interventions to halt or slow progression of the disease, and optimize patient outcomes. This article aims to examine in detail the normal function of the basal ganglia and dopaminergic neurons in the central nervous system, the etiology and pathophysiology of Parkinson disease, related signs and symptoms, current treatment, and finally, the profound impact of understanding the disease on nursing care.

  1. Overview of a special issue on complexity, alignment, and enrichment in communication partner training for aphasia

    DEFF Research Database (Denmark)

    Simmons-Mackie, NIna; Ahlsén, Elisabeth; Jensen, Lise Randrup


    Background: Communication partner training (CPT) is a widely recognized approach in aphasia; yet, the critical elements that contribute to successful CPT remain unclear. Further scrutiny of theoretical constructs, rationales, approaches and outcomes is needed in order to further the development...... of CPT and ensure effective and efficient practices. Aims: The objective of this introduction is to describe the rationale and create a context for the articles in this special issue on CPT in aphasia. Main Contribution: This introduction defines communication partner training, briefly describes...... significant research and approaches to CPT in aphasia, and explains how the concepts of complexity, alignment and enrichment might expand our understanding of CPT and contribute to innovative research and practice in the area. Conclusions: This introduction and special issue expands our understanding of CPT...

  2. Argumentation as a Strategy for Increasing Preservice Teachers’ Understanding of Climate Change, a Key Global Socioscientific Issue


    Lambert, Julie L.; Bleicher, Robert E.


    Findings of this study suggest that scientific argumentation can play an effective role in addressing complex socioscientific issues (i.e. global climate change). This research examined changes in preservice teachers’ knowledge and perceptions about climate change in an innovative undergraduate-level elementary science methods course. The preservice teachers’ understanding of fundamental concepts (e.g., the difference between weather and climate, causes of recent global warming, etc.) increas...

  3. Evolution in students’ understanding of thermal physics with increasing complexity

    Directory of Open Access Journals (Sweden)

    Elon Langbeheim


    Full Text Available We analyze the development in students’ understanding of fundamental principles in the context of learning a current interdisciplinary research topic—soft matter—that was adapted to the level of high school students. The topic was introduced in a program for interested 11th grade high school students majoring in chemistry and/or physics, in an off-school setting. Soft matter was presented in a gradual increase in the degree of complexity of the phenomena as well as in the level of the quantitative analysis. We describe the evolution in students’ use of fundamental thermodynamics principles to reason about phase separation—a phenomenon that is ubiquitous in soft matter. In particular, we examine the impact of the use of free energy analysis, a common approach in soft matter, on the understanding of the fundamental principles of thermodynamics. The study used diagnostic questions and classroom observations to gauge the student’s learning. In order to gain insight on the aspects that shape the understanding of the basic principles, we focus on the responses and explanations of two case-study students who represent two trends of evolution in conceptual understanding in the group. We analyze changes in the two case studies’ management of conceptual resources used in their analysis of phase separation, and suggest how their prior knowledge and epistemological framing (a combination of their personal tendencies and their prior exposure to different learning styles affect their conceptual evolution. Finally, we propose strategies to improve the instruction of these concepts.

  4. Foundational Issues in Educating Young People for Understanding and Appreciation of the Religions in Their Communities (United States)

    Engebretson, Kathleen


    This is a conceptual paper considering some of the foundational issues that a teacher needs to have at least considered (if not resolved) when he or she sets out to encourage students to understand and appreciate the variety of religions in their communities. The first issue is that of what to call the enterprise; the second relates to assumed…

  5. Neuroanthropological Understanding of Complex Cognition – Numerosity and Arithmetics

    Directory of Open Access Journals (Sweden)

    Zarja Mursic


    Full Text Available Humankind has a long evolutionary history. When we are trying to understand human complex cognition, it is as well important to look back to entire evolution. I will present the thesis that our biological predispositions and culture, together with natural and social environment, are tightly connected. During ontogenetically development we are shaped by various factors, and they enabled humans to develop some aspects of complex cognition, such as mathematics.In the beginning of the article I present the importance of natural and cultural evolution in other animals. In the following part, I briefly examine the field of mathematics – numerosity and arithmetic. Presentation of comparative animal studies, mainly made on primates, provides some interesting examples in animals’ abilities to separate between different quantities. From abilities for numerosity in animals I continue to neuroscientific studies of humans and our ability to solve simple arithmetic tasks. I also mention cross-cultural studies of arithmetic skills. In the final part of the text I present the field neuroanthropology as a possible new pillar of cognitive science. Finally, it is important to connect human evolution and development with animal cognition studies, but as well with cross-cultural studies in shaping of human ability for numerosity and arithmetic.

  6. Understanding and measuring quality of care: dealing with complexity. (United States)

    Hanefeld, Johanna; Powell-Jackson, Timothy; Balabanova, Dina


    Existing definitions and measurement approaches of quality of health care often fail to address the complexities involved in understanding quality of care. It is perceptions of quality, rather than clinical indicators of quality, that drive service utilization and are essential to increasing demand. Here we reflect on the nature of quality, how perceptions of quality influence health systems and what such perceptions indicate about measurement of quality within health systems. We discuss six specific challenges related to the conceptualization and measurement of the quality of care: perceived quality as a driver of service utilization; quality as a concept shaped over time through experience; responsiveness as a key attribute of quality; the role of management and other so-called upstream factors; quality as a social construct co-produced by families, individuals, networks and providers; and the implications of our observations for measurement. Within the communities and societies where care is provided, quality of care cannot be understood outside social norms, relationships, trust and values. We need to improve not only technical quality but also acceptability, responsiveness and levels of patient-provider trust. Measurement approaches need to be reconsidered. An improved understanding of all the attributes of quality in health systems and their interrelationships could support the expansion of access to essential health interventions.

  7. Understanding complexity in neurodegenerative diseases: in silico reconstruction of emergence

    Directory of Open Access Journals (Sweden)

    Alexey eKolodkin


    Full Text Available Healthy functioning is an emergent property of the network of interacting biomolecules that comprise an organism. It follows that disease (a network shift that causes malfunction is also an emergent property, emerging from a perturbation of the network. On one hand, the biomolecular network of every individual is unique and this is evident when similar disease-producing agents cause different individual pathologies. Consequently, a personalized model and approach for every patient may be required for therapies to become effective across mankind. On the other hand, diverse combinations of internal and external perturbation factors may cause a similar shift in network functioning. We offer this as an explanation for the multi-factorial nature of most diseases: they are ‘systems biology diseases’, or ‘network diseases’. Here we focus on neurodegenerative diseases, like Parkinson’s disease, as an example. Because of the inherent complexity of these networks, it is difficult to understand multi-factorial diseases using simply our ‘naked brain’. When describing interactions between biomolecules through mathematical equations and integrating those equations into a mathematical model, we try to reconstruct the emergent properties of the system in silico. The reconstruction of emergence from interactions between huge numbers of macromolecules is one of the aims of systems biology. Systems biology approaches enable us to break through the limitation of the human brain to perceive the extraordinarily large number of interactions, but this also means that we delegate the understanding of reality to the computer. We no longer recognize all those essences in the system’s design crucial for important physiological behavior (the so-called ‘design principles’ of the system. In this paper we review evidence that by using more abstract approaches and by experimenting in silico, one may still be able to discover and understand the design

  8. Understanding and controlling complex states arising from magnetic frustration

    Energy Technology Data Exchange (ETDEWEB)

    Zapf, Vivien [Los Alamos National Laboratory


    Much of our national security relies on capabilities made possible by magnetism, in particular the ability to compute and store huge bodies of information as well as to move things and sense the world. Most of these technologies exploit ferromagnetism, i.e. the global parallel alignment of magnetic spins as seen in a bar magnet. Recent advances in computing technologies, such as spintronics and MRAM, take advantage of antiferromagnetism where the magnetic spins alternate from one to the next. In certain crystal structures, however, the spins take on even more complex arrangements. These are often created by frustration, where the interactions between spins cannot be satisfied locally or globally within the material resulting in complex and often non-coplanar spin textures. Frustration also leads to the close proximity of many different magnetic states, which can be selected by small perturbations in parameters like magnetic fields, temperature and pressure. It is this tunability that makes frustrated systems fundamentally interesting and highly desirable for applications. We move beyond frustration in insulators to itinerant systems where the interaction between mobile electrons and the non-coplanar magnetic states lead to quantum magneto-electric amplification. Here a small external field is amplified by many orders of magnitude by non-coplanar frustrated states. This greatly enhances their sensitivity and opens broader fields for applications. Our objective is to pioneer a new direction for condensed matter science at the Laboratory as well as for international community by discovering, understanding and controlling states that emerge from the coupling of itinerant charges to frustrated spin textures.

  9. Integrated Bayesian network framework for modeling complex ecological issues. (United States)

    Johnson, Sandra; Mengersen, Kerrie


    The management of environmental problems is multifaceted, requiring varied and sometimes conflicting objectives and perspectives to be considered. Bayesian network (BN) modeling facilitates the integration of information from diverse sources and is well suited to tackling the management challenges of complex environmental problems. However, combining several perspectives in one model can lead to large, unwieldy BNs that are difficult to maintain and understand. Conversely, an oversimplified model may lead to an unrealistic representation of the environmental problem. Environmental managers require the current research and available knowledge about an environmental problem of interest to be consolidated in a meaningful way, thereby enabling the assessment of potential impacts and different courses of action. Previous investigations of the environmental problem of interest may have already resulted in the construction of several disparate ecological models. On the other hand, the opportunity may exist to initiate this modeling. In the first instance, the challenge is to integrate existing models and to merge the information and perspectives from these models. In the second instance, the challenge is to include different aspects of the environmental problem incorporating both the scientific and management requirements. Although the paths leading to the combined model may differ for these 2 situations, the common objective is to design an integrated model that captures the available information and research, yet is simple to maintain, expand, and refine. BN modeling is typically an iterative process, and we describe a heuristic method, the iterative Bayesian network development cycle (IBNDC), for the development of integrated BN models that are suitable for both situations outlined above. The IBNDC approach facilitates object-oriented BN (OOBN) modeling, arguably viewed as the next logical step in adaptive management modeling, and that embraces iterative development

  10. Large system change challenges: addressing complex critical issues in linked physical and social domains (United States)

    Waddell, Steve; Cornell, Sarah; Hsueh, Joe; Ozer, Ceren; McLachlan, Milla; Birney, Anna


    Most action to address contemporary complex challenges, including the urgent issues of global sustainability, occurs piecemeal and without meaningful guidance from leading complex change knowledge and methods. The potential benefit of using such knowledge is greater efficacy of effort and investment. However, this knowledge and its associated tools and methods are under-utilized because understanding about them is low, fragmented between diverse knowledge traditions, and often requires shifts in mindsets and skills from expert-led to participant-based action. We have been engaged in diverse action-oriented research efforts in Large System Change for sustainability. For us, "large" systems can be characterized as large-scale systems - up to global - with many components, of many kinds (physical, biological, institutional, cultural/conceptual), operating at multiple levels, driven by multiple forces, and presenting major challenges for people involved. We see change of such systems as complex challenges, in contrast with simple or complicated problems, or chaotic situations. In other words, issues and sub-systems have unclear boundaries, interact with each other, and are often contradictory; dynamics are non-linear; issues are not "controllable", and "solutions" are "emergent" and often paradoxical. Since choices are opportunity-, power- and value-driven, these social, institutional and cultural factors need to be made explicit in any actionable theory of change. Our emerging network is sharing and building a knowledge base of experience, heuristics, and theories of change from multiple disciplines and practice domains. We will present our views on focal issues for the development of the field of large system change, which include processes of goal-setting and alignment; leverage of systemic transitions and transformation; and the role of choice in influencing critical change processes, when only some sub-systems or levels of the system behave in purposeful ways

  11. Resolution of Hanford tanks organic complexant safety issue

    International Nuclear Information System (INIS)

    Kirch, N.W.


    The Hanford Site tanks have been assessed for organic complexant reaction hazards. The results have shown that most tanks contain insufficient concentrations of TOC to support a propagating reaction. It has also been shown that those tanks where the TOC concentration approaches levels of concern, degradation of the organic complexants to less energetic compounds has occurred. The results of the investigations have been documented. The residual organic complexants in the Hanford Site waste tanks do not present a safety concern for long-term storage

  12. Experienced ESD-Schoolteachers' Teaching--An Issue of Complexity (United States)

    Sund, Per


    In educational settings, sustainable development (SD) is often handled with the aim of reducing the contested aspects of the concept. Issues like trade, conservation, public health and international relations are often presented in a simplified way so that they are easier for students to grasp. However, in education, this tendency to simplify…

  13. Introduction to Special Issue: Leadership in Complex Adaptive Systems

    NARCIS (Netherlands)

    Comfort, L.K.; Resodihardjo, S.L.


    The concept of leadership involves making judgments that lead to action at different scales of responsibility and operations. It means the capacity to engage not only individuals in solving immediate problems, but also groups and organizations as they address broader issues of collective interest,

  14. Bringing content understanding into usability testing in complex application domains—a case study in eHealth

    DEFF Research Database (Denmark)

    Andersen, Simon Bruntse; Rasmussen, Claire Kirchert; Frøkjær, Erik


    A usability evaluation technique, Cooperative Usability Testing with Questions of Understanding (CUT with QU) intended to illuminate users’ ability to understand the content information of an application is proposed. In complex application domains as for instance the eHealth domain, this issue...... of users’ content understanding is sometimes crucial, and thus should be carefully evaluated. Unfortunately, conventional usability evaluation techniques do not address challenges of content understanding. In a case study within eHealth, specifically the setting of a rehabilitation clinic involving...... the participation of four physiotherapists and four clients in a period of 3.5 months, it was demonstrated how CUT with QU can complement conventional usability testing and provide insight into users’ challenges with understanding of a new complex eHealth application. More experiments in other complex application...

  15. Students' Understandings of Religious Identities and Relations: Issues of Social Cohesion and Citizenship (United States)

    Keddie, Amanda


    The focus in this article is on issues of social cohesion and citizenship as they relate to students' understandings of religion and religious identity. The article draws on data gathered from a study conducted at a highly diverse English comprehensive school and is set amid broader anxieties about religion, community disharmony and national…

  16. College Students' Use of Science Content during Socioscientific Issues Negotiation: Impact of Evolution Understanding and Acceptance (United States)

    Fowler, Samantha R.


    The purpose of this study was to explore the evolution science content used during college students' negotiation of biology-based socioscientific issues (SSI) and examine how it related to students' conceptual understanding and acceptance of biological evolution. Specific research questions were, (1a) what specific evolutionary science content do…

  17. Western Australian High School Students' Understandings about the Socioscientific Issue of Climate Change (United States)

    Dawson, Vaille


    Climate change is one of the most significant science issues facing humanity; yet, teaching students about climate change is challenging: not only is it multidisciplinary, but also it is contentious and debated in political, social and media forums. Students need to be equipped with an understanding of climate change science to be able to…

  18. System for decision analysis support on complex waste management issues

    International Nuclear Information System (INIS)

    Shropshire, D.E.


    A software system called the Waste Flow Analysis has been developed and applied to complex environmental management processes for the United States Department of Energy (US DOE). The system can evaluate proposed methods of waste retrieval, treatment, storage, transportation, and disposal. Analysts can evaluate various scenarios to see the impacts to waste slows and schedules, costs, and health and safety risks. Decision analysis capabilities have been integrated into the system to help identify preferred alternatives based on a specific objectives may be to maximize the waste moved to final disposition during a given time period, minimize health risks, minimize costs, or combinations of objectives. The decision analysis capabilities can support evaluation of large and complex problems rapidly, and under conditions of variable uncertainty. The system is being used to evaluate environmental management strategies to safely disposition wastes in the next ten years and reduce the environmental legacy resulting from nuclear material production over the past forty years

  19. Facilitating Site Specific and Citizens Advisory Boards: Running Effective Meetings that Involve Complex Technical Issues

    International Nuclear Information System (INIS)

    Freeman, J.


    the Board with a different level of knowledge and interest? A facilitator need not be a scientist or an engineer, but he or she must be proactive in learning the site issues, responsive to concerns about meeting content that is too technical or not technical enough, and resilient when working with individuals for whom the goals of the Board are not necessarily their own. When an SSAB or a CAB is working together purposively with ground rules understood and respect given to each Board member, a facilitator is free to develop effective processes to help Board participants and the members of the public focus on the content and substance of their work together. What are the processes that confront the challenge of ensuring that SSAB and CAB members understand complex technical cleanup issues? How can a facilitator be effective in working with members of the public so that their input is as valuable as possible while balanced with the goals of the Board? This paper will explore the unique environments of this nation's SSABs and CABs; discuss the nature of issues that come before the Boards; examine the make-up of the Boards regarding their potential for understanding complex technical issues and discuss facilitation techniques that provide structure while encouraging participation, interactive work on the tasks at hand, and satisfaction. (authors)

  20. Understanding global health governance as a complex adaptive system. (United States)

    Hill, Peter S


    The transition from international to global health reflects the rapid growth in the numbers and nature of stakeholders in health, as well as the constant change embodied in the process of globalisation itself. This paper argues that global health governance shares the characteristics of complex adaptive systems, with its multiple and diverse players, and their polyvalent and constantly evolving relationships, and rich and dynamic interactions. The sheer quantum of initiatives, the multiple networks through which stakeholders (re)configure their influence, the range of contexts in which development for health is played out - all compound the complexity of this system. This paper maps out the characteristics of complex adaptive systems as they apply to global health governance, linking them to developments in the past two decades, and the multiple responses to these changes. Examining global health governance through the frame of complexity theory offers insight into the current dynamics of governance, and while providing a framework for making meaning of the whole, opens up ways of accessing this complexity through local points of engagement.

  1. Developing integrated methods to address complex resource and environmental issues (United States)

    Smith, Kathleen S.; Phillips, Jeffrey D.; McCafferty, Anne E.; Clark, Roger N.


    IntroductionThis circular provides an overview of selected activities that were conducted within the U.S. Geological Survey (USGS) Integrated Methods Development Project, an interdisciplinary project designed to develop new tools and conduct innovative research requiring integration of geologic, geophysical, geochemical, and remote-sensing expertise. The project was supported by the USGS Mineral Resources Program, and its products and acquired capabilities have broad applications to missions throughout the USGS and beyond.In addressing challenges associated with understanding the location, quantity, and quality of mineral resources, and in investigating the potential environmental consequences of resource development, a number of field and laboratory capabilities and interpretative methodologies evolved from the project that have applications to traditional resource studies as well as to studies related to ecosystem health, human health, disaster and hazard assessment, and planetary science. New or improved tools and research findings developed within the project have been applied to other projects and activities. Specifically, geophysical equipment and techniques have been applied to a variety of traditional and nontraditional mineral- and energy-resource studies, military applications, environmental investigations, and applied research activities that involve climate change, mapping techniques, and monitoring capabilities. Diverse applied geochemistry activities provide a process-level understanding of the mobility, chemical speciation, and bioavailability of elements, particularly metals and metalloids, in a variety of environmental settings. Imaging spectroscopy capabilities maintained and developed within the project have been applied to traditional resource studies as well as to studies related to ecosystem health, human health, disaster assessment, and planetary science. Brief descriptions of capabilities and laboratory facilities and summaries of some

  2. Understanding sustainability from an exergetic frame in complex adaptive systems

    International Nuclear Information System (INIS)

    Aguilar Hernandez, Glem Alonso


    The concept of sustainability was developed from thermodynamic properties applied to complex adaptive systems. The origins of the perception about sustainable development and limitation in its application to analyze the interaction between a system and its surroundings were described. The properties of a complex adaptive system were taken as basis to determine how a system can to be affected by the resources restriction and irreversibility of the processes. The complex adaptive system was understood using the first and second law of thermodynamics, generating a conceptual framework to define the sustainability of a system. The contributions developed by exergy were shown to analyze the sustainability of systems in an economic, social and environmental context [es

  3. Understanding dyadic promoter-stakeholder relations in complex projects

    Directory of Open Access Journals (Sweden)

    Janita Vos


    Full Text Available In this study, we propose a Bilateral Double Motive framework of stakeholder cooperation in complex projects. The framework analyses and explains dyadic promoter-stakeholder relationships at a micro level by acknowledging both transactional and relational motives. We demonstrate the framework’s usefulness by illustrating its explanatory power in two instances of cooperation and two of non-cooperation within two health information technology projects. The study contributes to project management theory through its combined focus on transactional and relational motives. Further, the study contributes to practice by providing a tool for planning and evaluating cooperation in health Information Technology projects and similar complex multi-stakeholder environments.

  4. Matrix Models – An Approach to Understand Complex Systems

    Indian Academy of Sciences (India)

    Matrices with random matrix elements appear to have applications in physics, mathematics, bi- ology, telecommunications, etc. In fact, experi- mental data of many complex systems, such as the spacing distribution of energy level spectra of heavy nuclei, and the distribution of the non- real zeros of the Riemann zeta function ...

  5. Understanding dyadic promoter-stakeholder relations in complex projects

    NARCIS (Netherlands)

    Vos, Janita F.J.; Boonstra, Albert; Achterkamp, Marjolein C.


    In this study, we propose a Bilateral Double Motive framework of stakeholder cooperation in complex projects. The framework analyses and explains dyadic promoter-stakeholder relationships at a micro level by acknowledging both transactional and relational motives. We demonstrate the framework’s

  6. Argumentation in elementary science education: addressing methodological issues and conceptual understanding (United States)

    Kaya, Ebru


    In this review essay I respond to issues raised in Mijung Kim and Wolff-Michael Roth's paper titled "Dialogical argumentation in elementary science classrooms", which presents a study dealing with dialogical argumentation in early elementary school classrooms. Since there is very limited research on lower primary school students' argumentation in school science, their paper makes a contribution to research on children's argumentation skills. In this response, I focus on two main issues to extend the discussion in Kim and Roth's paper: (a) methodological issues including conducting a quantitative study on children's argumentation levels and focusing on children's written argumentation in addition to their dialogical argumentation, and (b) investigating children's conceptual understanding along with their argumentation levels. Kim and Roth emphasize the difficulty in determining the level of children's argumentation through the Toulmin's Argument Pattern and lack of high level arguments by children due to their difficulties in writing texts. Regarding these methodological issues, I suggest designing quantitative research on coding children's argument levels because such research could potentially provide important findings on children's argumentation. Furthermore, I discuss alternative written products including posters, figures, or pictures generated by children in order to trace children's arguments, and finally articulating argumentation and conceptual understanding of children.

  7. How Information Visualization Systems Change Users' Understandings of Complex Data (United States)

    Allendoerfer, Kenneth Robert


    User-centered evaluations of information systems often focus on the usability of the system rather its usefulness. This study examined how a using an interactive knowledge-domain visualization (KDV) system affected users' understanding of a domain. Interactive KDVs allow users to create graphical representations of domains that depict important…

  8. Western Australian High School Students' Understandings about the Socioscientific Issue of Climate Change (United States)

    Dawson, Vaille


    Climate change is one of the most significant science issues facing humanity; yet, teaching students about climate change is challenging: not only is it multidisciplinary, but also it is contentious and debated in political, social and media forums. Students need to be equipped with an understanding of climate change science to be able to participate in this discourse. The purpose of this study was to examine Western Australian high school students' understanding of climate change and the greenhouse effect, in order to identify their alternative conceptions about climate change science and provide a baseline for more effective teaching. A questionnaire designed to elicit students' understanding and alternative conceptions was completed by 438 Year 10 students (14-15 years old). A further 20 students were interviewed. Results showed that students know different features of both climate change and the greenhouse effect, however not necessarily all of them and the relationships between. Five categories of alternative conceptions were identified. The categories were (1) the greenhouse effect and the ozone layer; (2) types of greenhouse gases; (3) types of radiation; (4) weather and climate and (5) air pollution. These findings provide science educators a basis upon which to develop strategies and curriculum resources to improve their students' understanding and decision-making skills about the socioscientific issue, climate change.

  9. Bringing content understanding into usability testing in complex application domains—a case study in eHealth

    DEFF Research Database (Denmark)

    Andersen, Simon Bruntse; Rasmussen, Claire Kirchert; Frøkjær, Erik


    A usability evaluation technique, Cooperative Usability Testing with Questions of Understanding (CUT with QU) intended to illuminate users’ ability to understand the content information of an application is proposed. In complex application domains as for instance the eHealth domain, this issue...... the participation of four physiotherapists and four clients in a period of 3.5 months, it was demonstrated how CUT with QU can complement conventional usability testing and provide insight into users’ challenges with understanding of a new complex eHealth application. More experiments in other complex application...... domains involving different kinds of users and evaluators are needed before we can tell whether CUT with QU is an effective usability testing technique of wider applicability. Performing CUT with QU is very demanding by drawing heavily on the evaluators’ ability to respond effectively to openings...

  10. Essential issues in SOC design designing complex systems-on-chip

    CERN Document Server

    Lin, Youn-long Steve


    Covers issues related to system-on-chip (SoC) design. This book covers IP development, verification, integration, chip implementation, testing and software. It contains valuable academic and industrial examples for those involved with the design of complex SOCs.

  11. Understanding the topological characteristics and flow complexity of urban traffic congestion (United States)

    Wen, Tzai-Hung; Chin, Wei-Chien-Benny; Lai, Pei-Chun


    For a growing number of developing cities, the capacities of streets cannot meet the rapidly growing demand of cars, causing traffic congestion. Understanding the spatial-temporal process of traffic flow and detecting traffic congestion are important issues associated with developing sustainable urban policies to resolve congestion. Therefore, the objective of this study is to propose a flow-based ranking algorithm for investigating traffic demands in terms of the attractiveness of street segments and flow complexity of the street network based on turning probability. Our results show that, by analyzing the topological characteristics of streets and volume data for a small fraction of street segments in Taipei City, the most congested segments of the city were identified successfully. The identified congested segments are significantly close to the potential congestion zones, including the officially announced most congested streets, the segments with slow moving speeds at rush hours, and the areas near significant landmarks. The identified congested segments also captured congestion-prone areas concentrated in the business districts and industrial areas of the city. Identifying the topological characteristics and flow complexity of traffic congestion provides network topological insights for sustainable urban planning, and these characteristics can be used to further understand congestion propagation.

  12. Fusion in computer vision understanding complex visual content

    CERN Document Server

    Ionescu, Bogdan; Piatrik, Tomas


    This book presents a thorough overview of fusion in computer vision, from an interdisciplinary and multi-application viewpoint, describing successful approaches, evaluated in the context of international benchmarks that model realistic use cases. Features: examines late fusion approaches for concept recognition in images and videos; describes the interpretation of visual content by incorporating models of the human visual system with content understanding methods; investigates the fusion of multi-modal features of different semantic levels, as well as results of semantic concept detections, fo

  13. Understanding the Complex Patterns Observed during Hepatitis B Virus Therapy. (United States)

    Carracedo Rodriguez, Andrea; Chung, Matthias; Ciupe, Stanca M


    Data from human clinical trials have shown that the hepatitis B virus (HBV) follows complex profiles, such as bi-phasic, tri-phasic, stepwise decay and rebound. We utilized a deterministic model of HBV kinetics following antiviral therapy to uncover the mechanistic interactions behind HBV dynamics. Analytical investigation of the model was used to separate the parameter space describing virus decay and rebound. Monte Carlo sampling of the parameter space was used to determine the virological, pharmacological and immunological factors that separate the bi-phasic and tri-phasic virus profiles. We found that the level of liver infection at the start of therapy best separates the decay patterns. Moreover, drug efficacy, ratio between division of uninfected and infected cells, and the strength of cytotoxic immune response are important in assessing the amount of liver damage experienced over time and in quantifying the duration of therapy leading to virus resolution in each of the observed profiles.

  14. Quantifying 'causality' in complex systems: understanding transfer entropy.

    Directory of Open Access Journals (Sweden)

    Fatimah Abdul Razak

    Full Text Available 'Causal' direction is of great importance when dealing with complex systems. Often big volumes of data in the form of time series are available and it is important to develop methods that can inform about possible causal connections between the different observables. Here we investigate the ability of the Transfer Entropy measure to identify causal relations embedded in emergent coherent correlations. We do this by firstly applying Transfer Entropy to an amended Ising model. In addition we use a simple Random Transition model to test the reliability of Transfer Entropy as a measure of 'causal' direction in the presence of stochastic fluctuations. In particular we systematically study the effect of the finite size of data sets.

  15. Quantifying ‘Causality’ in Complex Systems: Understanding Transfer Entropy (United States)

    Abdul Razak, Fatimah; Jensen, Henrik Jeldtoft


    ‘Causal’ direction is of great importance when dealing with complex systems. Often big volumes of data in the form of time series are available and it is important to develop methods that can inform about possible causal connections between the different observables. Here we investigate the ability of the Transfer Entropy measure to identify causal relations embedded in emergent coherent correlations. We do this by firstly applying Transfer Entropy to an amended Ising model. In addition we use a simple Random Transition model to test the reliability of Transfer Entropy as a measure of ‘causal’ direction in the presence of stochastic fluctuations. In particular we systematically study the effect of the finite size of data sets. PMID:24955766

  16. Understanding Complex Human Ecosystems: The Case of Ecotourism on Bonaire

    Directory of Open Access Journals (Sweden)

    Thomas Abel


    Full Text Available It is suggested that ecotourism development on the island of Bonaire can be productively understood as a perturbation of a complex human ecosystem. Inputs associated with ecotourism have fueled transformations of the island ecology and sociocultural system. The results of this study indicate that Bonaire's social and economic hierarchy is approaching a new, stable systems state following a 50-yr transition begun by government and industry that stabilized with the appearance of ecotourism development and population growth. Ecotourism can be understood to have "filled in" the middle of the production hierarchy of Bonaire. Interpreted from this perspective, population growth has completed the transformation by expanding into production niches at smaller scales in the production hierarchy. Both a consequence and a cause, ecotourism has transformed the island's social structure and demography. The theory and methods applied in this case study of interdisciplinary research in the field of human ecosystems are also presented.

  17. From structure of the complex to understanding of the biology

    Energy Technology Data Exchange (ETDEWEB)

    Rossmann, Michael G., E-mail: [Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054 (United States); Arisaka, Fumio [Graduate School and School of Bioscience and Biotechnology, Tokyo Institute of Technology, 5249 Nagatsuta-cho, Yokohama 226-8501-B39 (Japan); Battisti, Anthony J.; Bowman, Valorie D.; Chipman, Paul R.; Fokine, Andrei; Hafenstein, Susan [Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054 (United States); Kanamaru, Shuji [Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054 (United States); Graduate School and School of Bioscience and Biotechnology, Tokyo Institute of Technology, 5249 Nagatsuta-cho, Yokohama 226-8501-B39 (Japan); Kostyuchenko, Victor A. [Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054 (United States); Mesyanzhinov, Vadim V.; Shneider, Mikhail M. [Laboratory of Molecular Bioengineering, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya Street, Moscow, 117997 (Russian Federation); Morais, Marc C.; Leiman, Petr G. [Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054 (United States); Palermo, Laura M.; Parrish, Colin R. [James A. Baker Institute, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (United States); Xiao, Chuan [Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054 (United States)


    The most extensive structural information on viruses relates to apparently icosahedral virions and is based on X-ray crystallography and on cryo-electron microscopy single-particle reconstructions. This paper concerns itself with the study of the macromolecular complexes that constitute viruses, using structural hybrid techniques. The most extensive structural information on viruses relates to apparently icosahedral virions and is based on X-ray crystallography and on cryo-electron microscopy (cryo-EM) single-particle reconstructions. Both techniques lean heavily on imposing icosahedral symmetry, thereby obscuring any deviation from the assumed symmetry. However, tailed bacteriophages have icosahedral or prolate icosahedral heads that have one obvious unique vertex where the genome can enter for DNA packaging and exit when infecting a host cell. The presence of the tail allows cryo-EM reconstructions in which the special vertex is used to orient the head in a unique manner. Some very large dsDNA icosahedral viruses also develop special vertices thought to be required for infecting host cells. Similarly, preliminary cryo-EM data for the small ssDNA canine parvovirus complexed with receptor suggests that these viruses, previously considered to be accurately icosahedral, might have some asymmetric properties that generate one preferred receptor-binding site on the viral surface. Comparisons are made between rhinoviruses that bind receptor molecules uniformly to all 60 equivalent binding sites, canine parvovirus, which appears to have a preferred receptor-binding site, and bacteriophage T4, which gains major biological advantages on account of its unique vertex and tail organelle.

  18. Short message service or disService: issues with text messaging in a complex medical environment. (United States)

    Wu, Robert; Appel, Lora; Morra, Dante; Lo, Vivian; Kitto, Simon; Quan, Sherman


    Hospitals today are experiencing major changes in their clinical communication workflows as conventional numeric paging and face-to-face verbal conversations are being replaced by computer mediated communication systems. In this paper, we highlight the importance of understanding this transition and discuss some of the impacts that may emerge when verbal clinical conversations are replaced by short text messages. In-depth interviews (n=108) and non-participatory observation sessions (n=260h) were conducted on the General Internal Medicine wards at five academic teaching hospitals in Toronto, Canada. From our analysis of the qualitative data, we identified two major themes. De-contextualization of complex issues led to an increase in misinterpretation and an increase in back and forth messaging for clarification. Depersonalization of communication was due to less verbal conversations and face-to-face interactions and led to a negative impact on work relationships. Text-based communication in hospital settings led to the oversimplification of messages and the depersonalization of communication. It is important to recognize and understand these unintended consequences of new technology to avoid the negative impacts to patient care and work relationships. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  19. Understanding complex host-microbe interactions in Hydra (United States)

    Bosch, Thomas C.G.


    Any multicellular organism may be considered a metaorganism or holobiont—comprised of the macroscopic host and synergistic interdependence with bacteria, archaea, fungi, viruses, and numerous other microbial and eukaryotic species including algal symbionts. Defining the individual microbe-host conversations in these consortia is a challenging but necessary step on the path to understanding the function of the associations as a whole. Dissecting the fundamental principles that underlie all host-microbe interactions requires simple animal models with only a few specific bacterial species. Here I present Hydra as such a model with one of the simplest epithelia in the animal kingdom, with the availability of a fully sequenced genome and numerous genomic tools, and with few associated bacterial species. PMID:22688725

  20. Understanding price elasticities to inform public health research and intervention studies: key issues. (United States)

    Nghiem, Nhung; Wilson, Nick; Genç, Murat; Blakely, Tony


    Pricing policies such as taxes and subsidies are important tools in preventing and controlling a range of threats to public health. This is particularly so in tobacco and alcohol control efforts and efforts to change dietary patterns and physical activity levels as a means of addressing increases in noncommunicable diseases. To understand the potential impact of pricing policies, it is critical to understand the nature of price elasticities for consumer products. For example, price elasticities are key parameters in models of any food tax or subsidy that aims to quantify health impacts and cost-effectiveness. We detail relevant terms and discuss key issues surrounding price elasticities to inform public health research and intervention studies.

  1. Understanding Life : The Evolutionary Dynamics of Complexity and Semiosis (United States)

    Loeckenhoff, Helmut K.


    Post-Renaissance sciences created different cultures. To establish an epistemological base, Physics were separated from the Mental domain. Consciousness was excluded from science. Life Sciences were left in between e.g. LaMettrie's `man—machine' (1748) and 'vitalism' [e.g. Bergson 4]. Causative thinking versus intuitive arguing limited strictly comprehensive concepts. First ethology established a potential shared base for science, proclaiming the `biology paradigm' in the middle of the 20th century. Initially procured by Cybernetics and Systems sciences, `constructivist' models prepared a new view on human perception and thus also of scientific `objectivity when introducing the `observer'. In sequel Computer sciences triggered the ICT revolution. In turn ICT helped to develop Chaos and Complexity sciences, Non-linear Mathematics and its spin-offs in the formal sciences [Spencer-Brown 49] as e.g. (proto-)logics. Models of life systems, as e.g. Anticipatory Systems, integrated epistemology with mathematics and Anticipatory Computing [Dubois 11, 12, 13, 14] connecting them with Semiotics. Seminal ideas laid in the turn of the 19th to the 20th century [J. v. Uexküll 53] detected the co-action and co-evolvement of environments and life systems. Bio-Semiotics ascribed purpose, intent and meaning as essential qualities of life. The concepts of Systems Biology and Qualitative Research enriched and develop also anthropologies and humanities. Brain research added models of (higher) consciousness. An avant-garde is contemplating a science including consciousness as one additional base. New insights from the extended qualitative approach led to re-conciliation of basic assumptions of scientific inquiry, creating the `epistemological turn'. Paradigmatically, resting on macro- micro- and recently on nano-biology, evolution biology sired fresh scripts of evolution [W. Wieser 60,61]. Its results tie to hypotheses describing the emergence of language, of the human mind and of

  2. Measurements of student understanding on complex scientific reasoning problems (United States)

    Izumi, Alisa Sau-Lin

    While there has been much discussion of cognitive processes underlying effective scientific teaching, less is known about the response nature of assessments targeting processes of scientific reasoning specific to biology content. This study used multiple-choice (m-c) and short-answer essay student responses to evaluate progress in high-order reasoning skills. In a pilot investigation of student responses on a non-content-based test of scientific thinking, it was found that some students showed a pre-post gain on the m-c test version while showing no gain on a short-answer essay version of the same questions. This result led to a subsequent research project focused on differences between alternate versions of tests of scientific reasoning. Using m-c and written responses from biology tests targeted toward the skills of (1) reasoning with a model and (2) designing controlled experiments, test score frequencies, factor analysis, and regression models were analyzed to explore test format differences. Understanding the format differences in tests is important for the development of practical ways to identify student gains in scientific reasoning. The overall results suggested test format differences. Factor analysis revealed three interpretable factors---m-c format, genetics content, and model-based reasoning. Frequency distributions on the m-c and open explanation portions of the hybrid items revealed that many students answered the m-c portion of an item correctly but gave inadequate explanations. In other instances students answered the m-c portion incorrectly yet demonstrated sufficient explanation or answered the m-c correctly and also provided poor explanations. When trying to fit test score predictors for non-associated student measures---VSAT, MSAT, high school grade point average, or final course grade---the test scores accounted for close to zero percent of the variance. Overall, these results point to the importance of using multiple methods of testing and of

  3. Consumer understanding and nutritional communication: key issues in the context of the new EU legislation. (United States)

    van Trijp, Hans C M


    Nutrition communication by means of nutrition and health claims and otherwise, holds the potential to contribute to public health by stimulating informed healthier food choices and enhanced health-focussed competition in the market place, provided that the health messages are trustworthy (i.e. scientifically substantiated) and correctly used and interpreted by the consumer. Not surprisingly, these two considerations constitute the cornerstone of the new EU legislation on nutrition and health claims, in which evidence for consumer understanding of nutrition and health claims is a new requirement. To review some of the key issues in consumer understanding of nutritional communication as a basis for reflection on the consumer understanding element of the new EU legislation on nutrition and health claims. There is a need for more methodologically advanced research in consumer understanding of nutrition and health claims as a basis for truly assessing the real-life use of such information and its actual effect on consumer food choices. Such approaches are pertinent in light of the evaluation and approval process of (new) nutrition and health claims as required under the new EU legislation on nutrition and health claims.

  4. Understanding the continuous renal replacement therapy circuit for acute renal failure support: a quality issue in the intensive care unit. (United States)

    Boyle, Martin; Baldwin, Ian


    Delivery of renal replacement therapy is now a core competency of intensive care nursing. The safe and effective delivery of this form of therapy is a quality issue for intensive care, requiring an understanding of the principles underlying therapy and the functioning of machines used. Continuous hemofiltration, first described in 1977, used a system where blood flowed from arterial to venous cannulas through a small-volume, low-resistance, and high-flux filter. Monitoring of these early systems was limited, and without a machine interface, less nursing expertise was required. Current continuous renal replacement therapy machines offer user-friendly interfaces, cassette-style circuits, and comprehensive circuit diagnostics and monitoring. Although these machines conceal complexity behind a user-friendly interface, it remains important that nurses have sufficient knowledge for their use and the ability to compare and contrast circuit setups and functions for optimal and efficient treatment.

  5. Entropy: A Unifying Path for Understanding Complexity in Natural, Artificial and Social Systems (United States)


    us now address complex systems which include a substantial social component. We may start with economics and theory of finance. Given the long memory ...Entropy: A Unifying Path for Understanding Complexity in Natural, Artificial and Social Systems * Constantino Tsallis Centro Brasileiro de...Path for Understanding Complexity in Natural, Artificial and Social Systems 5a. CONTRACT NUMBER FA23861114006 5b. GRANT NUMBER 5c. PROGRAM ELEMENT

  6. Western Mineral and Environmental Resources Science Center--providing comprehensive earth science for complex societal issues (United States)

    Frank, David G.; Wallace, Alan R.; Schneider, Jill L.


    supports approximately 40 USGS research specialists who utilize cooperative agreements with universities, industry, and other governmental agencies to support their collaborative research and information exchange. Scientists of the WMERSC study how and where non-fuel mineral resources form and are concentrated in the earth's crust, where mineral resources might be found in the future, and how mineral materials interact with the environment to affect human and ecosystem health. Natural systems (ecosystems) are complex - our understanding of how ecosystems operate requires collecting and synthesizing large amounts of geologic, geochemical, biologic, hydrologic, and meteorological information. Scientists in the Center strive to understand the interplay of various processes and how they affect the structure, composition, and health of ecosystems. Such understanding, which is then summarized in publicly available reports, is used to address and solve a wide variety of issues that are important to society and the economy. WMERSC scientists have extensive national and international experience in these scientific specialties and capabilities - they have collaborated with many Federal, State, and local agencies; with various private sector organizations; as well as with foreign countries and organizations. Nearly every scientific and societal challenge requires a different combination of scientific skills and capabilities. With their breadth of scientific specialties and capabilities, the scientists of the WMERSC can provide scientifically sound approaches to a wide range of societal challenges and issues. The following sections describe examples of important issues that have been addressed by scientists in the Center, the methods employed, and the relevant conclusions. New directions are inevitable as societal needs change over time. Scientists of the WMERSC have a diverse set of skills and capabilities and are proficient in the collection and integration of

  7. Perception and Understanding of Invasive Alien Species Issues by Nature Conservation and Horticulture Professionals in Belgium (United States)

    Vanderhoeven, Sonia; Piqueray, Julien; Halford, Mathieu; Nulens, Greet; Vincke, Jan; Mahy, Grégory


    We conducted a survey to determine how two professional sectors in Belgium, horticulture professionals and nature reserve managers (those directly involved in conservation), view the issues associated with invasive plant species. We developed and utilized a questionnaire that addressed the themes of awareness, concept and use of language, availability of information, impacts and, finally, control and available solutions. Using co-inertia analyses, we tested to what extent the perception of invasive alien species (IAS) was dependent upon the perception of Nature in general. Only forty-two percent of respondent horticulture professionals and eighty-two percent of nature reserve managers had a general knowledge of IAS. Many individuals in both target groups nonetheless had an accurate understanding of the scientific issues. Our results therefore suggest that the manner in which individuals within the two groups view, or perceive, the IAS issue was more the result of lack of information than simply biased perceptions of target groups. Though IAS perceptions by the two groups diverged, they were on par with how they viewed Nature in general. The descriptions of IAS by participants converged with the ideas and concepts frequently found in the scientific literature. Both managers and horticulture professionals expressed a strong willingness to participate in programs designed to prevent the spread of, and damage caused by, IAS. Despite this, the continued commercial availability of many invasive species highlighted the necessity to use both mandatory and voluntary approaches to reduce their re-introduction and spread. The results of this study provide stakeholders and conservation managers with practical information on which communication and management strategies can be based.

  8. Perception and understanding of invasive alien species issues by nature conservation and horticulture professionals in Belgium. (United States)

    Vanderhoeven, Sonia; Piqueray, Julien; Halford, Mathieu; Nulens, Greet; Vincke, Jan; Mahy, Grégory


    We conducted a survey to determine how two professional sectors in Belgium, horticulture professionals and nature reserve managers (those directly involved in conservation), view the issues associated with invasive plant species. We developed and utilized a questionnaire that addressed the themes of awareness, concept and use of language, availability of information, impacts and, finally, control and available solutions. Using co-inertia analyses, we tested to what extent the perception of invasive alien species (IAS) was dependent upon the perception of Nature in general. Only forty-two percent of respondent horticulture professionals and eighty-two percent of nature reserve managers had a general knowledge of IAS. Many individuals in both target groups nonetheless had an accurate understanding of the scientific issues. Our results therefore suggest that the manner in which individuals within the two groups view, or perceive, the IAS issue was more the result of lack of information than simply biased perceptions of target groups. Though IAS perceptions by the two groups diverged, they were on par with how they viewed Nature in general. The descriptions of IAS by participants converged with the ideas and concepts frequently found in the scientific literature. Both managers and horticulture professionals expressed a strong willingness to participate in programs designed to prevent the spread of, and damage caused by, IAS. Despite this, the continued commercial availability of many invasive species highlighted the necessity to use both mandatory and voluntary approaches to reduce their re-introduction and spread. The results of this study provide stakeholders and conservation managers with practical information on which communication and management strategies can be based.

  9. Understanding Technology and People Issues in Hospital Information System (HIS) Adoption: Case study of a tertiary hospital in Malaysia. (United States)

    Zakaria, Nasriah; Mohd Yusof, Shafiz Affendi

    Hospital Information Systems (HIS) can improve healthcare outcome quality, increase efficiency, and reduce errors. The government of Malaysia implemented HIS across the country to maximize the use of technology to improve healthcare delivery, however, little is known about the benefits and challenges of HIS adoption in each institution. This paper looks at the technology and people issues in adopting such systems. The study used a case study approach, using an in-depth interview with multidisciplinary medical team members who were using the system on a daily basis. A thematic analysis using Atlas.ti was employed to understand the complex relations among themes and sub-themes to discover the patterns in the data. . Users found the new system increased the efficiency of workflows and saved time. They reported less redundancy of work and improved communication among medical team members. Data retrieval and storage were also mentioned as positive results of the new HIS system. Healthcare workers showed positive attitudes during training and throughout the learning process. From a technological perspective, it was found that medical workers using HIS has better access and data management compared to the previously used manual system. The human issues analysis reveals positive attitudes toward using HIS among the users especially from the physicians' side. Copyright © 2016. Published by Elsevier Ltd.

  10. 'Understanding' as a practical issue in sexual health education for people with intellectual disabilities: a study using two qualitative methods. (United States)

    Finlay, W M L; Rohleder, Poul; Taylor, Natalie; Culfear, Hollie


    Sexual health education is important in addressing the health and social inequalities faced by people with intellectual disabilities. However, provision of health-related advice and education to people with various types and degrees of linguistic and learning difficulties involves addressing complex issues of language and comprehension. This article reports an exploratory study using 2 qualitative methods to examine the delivery of sexual health education to people with intellectual disabilities. Four video-recordings of sexual health education sessions were collected. Conversation analysis was used to examine in detail how such education occurs as a series of interactions between educators and learners. Interviews with 4 educators were carried out and analyzed using thematic analysis. The analysis shows how educators anticipate problems of comprehension and how they respond when there is evidence that a person does not understand the activity or the educational message. This occurs particularly when verbal prompts involve long sentences and abstract concepts. We show a characteristic pattern that arises in these situations, in which both educator and learner jointly produce a superficially correct response. Although interviews allows us some insight into contextual issues, strategy, and aspects of sexual health education that occur outside of the actual teaching sessions, analysis of actual interactions can show us patterns that occur in interactions between educators and learners when comprehension is in question. Addressing how sexual health education is delivered in practice and in detail provides valuable lessons about how such education can be improved. (c) 2015 APA, all rights reserved).

  11. Partner Country Series: Understanding Energy Challenges in India - Policies, Players and Issues

    Energy Technology Data Exchange (ETDEWEB)



    A combination of rapidly increasing energy demand and fuel imports plus growing concern about economic and environmental consequences is generating growing calls for effective and thorough energy governance in India. Numerous policy reforms over the past 20 years have shifted the country’s energy sector from a state-dominated system towards one that is based on market principles. However, with the reform process left unfinished, India now finds itself trapped halfway along the transition to an open and well-performing energy sector. India suffered from the largest power outage ever in late July 2012, affecting nearly half of the population. While this incident highlights the importance of modern and smart energy systems, it indicates that the country is increasingly unable to deliver a secure supply of energy to its population, a quarter of which still lacks access to electricity. Understanding Energy Challenges in India aims to provide an informative and holistic understanding of India’s energy sector to stakeholders in India as well as the broad public. The publication explores in detail the policies, players and issues of the country’s power, coal, oil and gas, renewables and nuclear sectors. It also highlights the key challenges India faces, challenges that must be resolved for the evolution of the fast-growing country’s energy sector towards a sustainable energy future and eventually critical for the prospects of the Indian and global economies.

  12. Measuring spatial patterns in floodplains: A step towards understanding the complexity of floodplain ecosystems: Chapter 6 (United States)

    Scown, Murray W.; Thoms, Martin C.; DeJager, Nathan R.; Gilvear, David J.; Greenwood, Malcolm T.; Thoms, Martin C.; Wood, Paul J.


    Floodplains can be viewed as complex adaptive systems (Levin, 1998) because they are comprised of many different biophysical components, such as morphological features, soil groups and vegetation communities as well as being sites of key biogeochemical processing (Stanford et al., 2005). Interactions and feedbacks among the biophysical components often result in additional phenomena occuring over a range of scales, often in the absence of any controlling factors (sensu Hallet, 1990). This emergence of new biophysical features and rates of processing can lead to alternative stable states which feed back into floodplain adaptive cycles (cf. Hughes, 1997; Stanford et al., 2005). Interactions between different biophysical components, feedbacks, self emergence and scale are all key properties of complex adaptive systems (Levin, 1998; Phillips, 2003; Murray et al., 2014) and therefore will influence the manner in which we study and view spatial patterns. Measuring the spatial patterns of floodplain biophysical components is a prerequisite to examining and understanding these ecosystems as complex adaptive systems. Elucidating relationships between pattern and process, which are intrinsically linked within floodplains (Ward et al., 2002), is dependent upon an understanding of spatial pattern. This knowledge can help river scientists determine the major drivers, controllers and responses of floodplain structure and function, as well as the consequences of altering those drivers and controllers (Hughes and Cass, 1997; Whited et al., 2007). Interactions and feedbacks between physical, chemical and biological components of floodplain ecosystems create and maintain a structurally diverse and dynamic template (Stanford et al., 2005). This template influences subsequent interactions between components that consequently affect system trajectories within floodplains (sensu Bak et al., 1988). Constructing and evaluating models used to predict floodplain ecosystem responses to

  13. Using Next Generation Science Standards (NGSS) Practices to Address Scientific Misunderstandings Around Complex Environmental Issues (United States)

    Turrin, M.; Kenna, T. C.


    The new NGSS provide an important opportunity for scientists to develop curriculum that links the practice of science to research-based data in order to improve understanding in areas of science that are both complex and confusing. Our curriculum focuses in particular on the fate and transport of anthropogenic radionuclides. Radioactivity, both naturally occurring and anthropogenic, is highly debated and largely misunderstood, and for large sections of the population is a source of scientific misunderstanding. Developed as part of the international GEOTRACES project which focuses on identifying ocean processes and quantifying fluxes that control the distributions of selected trace elements and isotopes in the ocean, and on establishing the sensitivity of these distributions to changing environmental conditions, the curriculum topic fits nicely into the applied focus of NGSS with both environmental and topical relevance. Our curriculum design focuses on small group discussion driven by questions, yet unlike more traditional curriculum pieces these are not questions posed to the students, rather they are questions posed by the students to facilitate their deeper understanding. Our curriculum design challenges the traditional question/answer memorization approach to instruction as we strive to develop an educational approach that supports the practice of science as well as the NGSS Cross Cutting Concepts and the Science & Engineering Practices. Our goal is for students to develop a methodology they can employ when faced with a complex scientific issue. Through background readings and team discussions they identify what type of information is important for them to know and where to find a reliable source for that information. Framing their discovery around key questions such as "What type of radioactive decay are we dealing with?", "What is the potential half-life of the isotope?", and "What are the pathways of transport of radioactivity?" allows students to evaluate a

  14. Global Learning in a Geography Course Using the Mystery Method as an Approach to Complex Issues (United States)

    Applis, Stefan


    In the study which is the foundation of this essay, the question is examined of whether the complexity of global issues can be solved at the level of teaching methodology. In this context, the first qualitative and constructive study was carried out which researches the Mystery Method using the Thinking-Through-Geography approach (David Leat,…

  15. Small System dynamics models for big issues : Triple jump towards real-world complexity

    NARCIS (Netherlands)

    Pruyt, E.


    System Dynamics (SD) is a method to describe, model, simulate and analyze dynamically complex issues and/or systems in terms of the processes, information, organizational boundaries and strategies. Quantitative SD modeling, simulation and analysis facilitates the (re)design of systems and design of

  16. Learning about Complex Multi-Stakeholder Issues: Assessing the Visual Problem Appraisal

    NARCIS (Netherlands)

    Witteveen, L.M.; Put, M.; Leeuwis, C.


    This paper presents an evaluation of the visual problem appraisal (VPA) learning environment in higher education. The VPA has been designed for the training of competences that are required in complex stakeholder settings in relation to sustainability issues. The design of VPA incorporates a

  17. Italy's All-Volunteer Army: An Analytical Framework for Understanding the Key Policy Issues and Choices During the Transition

    National Research Council Canada - National Science Library

    Zanini, Michele


    This dissertation builds an analytical framework for understanding the key policy issues and tradeoffs affecting the Italian Army's transition from a mixed conscript/volunteer model to an All-Volunteer Force (AVF...

  18. Using a Qualitative Vignette to Explore a Complex Public Health Issue. (United States)

    Jackson, Michaela; Harrison, Paul; Swinburn, Boyd; Lawrence, Mark


    This article discusses how qualitative vignettes were combined with interviews to explore a complex public health issue; that is, promoting unhealthy foods and beverages to children and adolescents. It outlines how the technique was applied in practice and the combination of vignette-based interviews with a broader approach involving Gadamerian hermeneutics. Twenty-one participants from the public health community and the marketing and food and beverage industries took part in vignette-based interviews between March and September 2012. Overall, the qualitative vignette method afforded an efficient, generally well-received technique that effectively explored the issue of promoting unhealthy foods and beverages to children and adolescents. The vignette provided structure to interviews but allowed certain responses to be investigated in greater depth. Through this research, we argue that qualitative vignettes allow researchers to explore complex public health issues. This article also provides a valuable resource for researchers seeking to explore this technique. © The Author(s) 2015.

  19. Understanding the Complexities of Communicating Management Decisions on the Subsistence Use of Yukon River Salmon (United States)

    Brooks, J. F.; Trainor, S.


    Over 20,000 residents in Alaska and Yukon Territory rely upon the Yukon River to provide them harvests of Pacific salmon each year. Salmon are a highly valued food resource and the practice of salmon fishing along the Yukon is deep rooted in local cultures and traditions. Potential future impacts of climate change on the health of Yukon River salmon stocks could be significant. Collaborative managerial processes which incorporate the viewpoints of subsistence stakeholders will be crucial in enabling communities and managerial institutions to adapt and manage these impacts. However, the massive extent of the Yukon River makes it difficult for communities rich with highly localized knowledge to situate themselves within a drainage-wide context of resource availability, and to fully understand the implications that management decisions may have for their harvest. Differences in salmon availability and abundance between the upper and lower Yukon, commercial vs. subsistence fishery interests, and enforcement of the international Pacific Salmon Treaty further complicate understanding and makes the topic of salmon as a subsistence resource a highly contentious issue. A map which synthesizes the presence and absence of Pacific salmon throughout the entire Yukon River drainage was requested by both subsistence fishers and natural resource managers in Alaska in order to help facilitate productive conversations about salmon management decisions. Interviews with Alaskan stakeholders with managerial, biological, and subsistence harvest backgrounds were carried out and a literature review was conducted in order to understand what such a map should and could accomplish. During the research process, numerous data gaps concerning the distribution of salmon along the Yukon River were discovered, and insights about the complexities involved in translating science when it is situated within a charged political, economic, and cultural context were revealed. Preliminary maps depicting

  20. Using Simulations in Linked Courses to Foster Student Understanding of Complex Political Institutions (United States)

    Williams, Michelle Hale


    Political institutions provide basic building blocks for understanding and comparing political systems. Yet, students often struggle to understand the implications of institutional choice, such as electoral system rules, especially when the formulas and calculations used to determine seat allocation can be multilevel and complex. This study brings…

  1. What Influences Children's and Adolescents' Understanding of the Complexity of the Internet? (United States)

    Yan, Zheng


    This study aimed at analyzing complex relationships among Internet use, Internet users, and conceptual understanding of the Internet. It used path models to examine factors related to Internet use (duration of Internet use, frequency of Internet use, and informal Internet classes) and Internet users (age and gender) in affecting understanding of…

  2. Higher Education Cloud Computing in South Africa: Towards Understanding Trust and Adoption issues

    Directory of Open Access Journals (Sweden)

    Karl Van Der Schyff


    Full Text Available This paper sets out to study the views of key stakeholders on the issue of cloud information security within institutions of Higher Education. A specific focus is on understanding trust and the adoption of cloud computing in context of the unique operational requirements of South African universities. Contributions are made on both a methodological and theoretical level. Methodologically the study contributes by employing an Interpretivist approach and using Thematic Analysis in a topic area often studied quantitatively, thus affording researchers the opportunity to gain the necessary in-depth insight into how key stakeholders view cloud security and trust. A theoretical contribution is made in the form of a trust-centric conceptual framework that illustrates how the qualitative data relates to concepts innate to cloud computing trust and adoption. Both these contributions lend credence to the fact that there is a need to address cloud information security with a specific focus on the contextual elements that surround South African universities. The paper concludes with some considerations for implementing and investigating cloud computing services in Higher Education contexts in South Africa.

  3. Understanding the Complex Dimensions of the Digital Divide: Lessons Learned in the Alaskan Arctic (United States)

    Subramony, Deepak Prem


    An ethnographic case study of Inupiat Eskimo in the Alaskan Arctic has provided insights into the complex nature of the sociological issues surrounding equitable access to technology tools and skills, which are referred to as the digital divide. These people can overcome the digital divide if they get the basic ready access to hardware and…

  4. The effects of antiepileptic inducers in neuropsychopharmacology, a neglected issue. Part II: Pharmacological issues and further understanding. (United States)

    de Leon, Jose


    The literature on inducers in epilepsy and bipolar disorder is seriously contaminated by false negative findings. Part II of this comprehensive review on antiepileptic drug (AED) inducers provides clinicians with further educational material about the complexity of interpreting AED drug-drug interactions. The basic pharmacology of induction is reviewed including the cytochrome P450 (CYP) isoenzymes, the Uridine Diphosphate Glucuronosyltransferases (UGTs), and P-glycoprotein (P-gp). CYP2B6 and CYP3A4 are very sensitive to induction. CYP1A2 is moderately sensitive while CYP2C9 and CYP2C19 are only mildly sensitive. CYP2D6 cannot be induced by medications. Induction of UGT and P-gp are poorly understood. The induction of metabolic enzymes such as CYPs and UGTs, and transporters such as P-gp, implies that the amount of these proteins increases when they are induced; this is almost always explained by increasing synthesis mediated by the so-called nuclear receptors (constitutive androstane, estrogen, glucocorticoid receptors and pregnaneX receptors). Although parti provides correction factors for AEDs, extrapolation from an average to an individual patient may be influenced by administration route, absence of metabolic enzyme for genetic reasons, and presence of inhibitors or other inducers. AED pharmacodynamic DDIs may also be important. Six patients with extreme sensitivity to AED inductive effects are described. Copyright © 2014 SEP y SEPB. Published by Elsevier España. All rights reserved.

  5. Scepticism and Trust: Two Counterpoint Essentials in Science Education for Complex Socio-Scientific Issues (United States)

    Fensham, Peter J.


    In this response to Tom G. K. Bryce and Stephen P. Day's ("Cult Stud Sci Educ." doi:10.1007/s11422-013-9500-0, 2013) original article, I share with them their interest in the teaching of climate change in school science, but I widen it to include other contemporary complex socio-scientific issues that also need to be discussed. I…

  6. Understanding a Complex World: Why an Emphasis on Empathy Could Better Enable Army Leaders to Win (United States)


    the problem of how to win in a complex world. 1 Brig. Gen. Oscar W. Koch and Robert G. Hayes, G-2: Intelligence for Patton (Atglen, PA: Schiffer...UNDERSTANDING A COMPLEX WORLD: WHY AN EMPHASIS ON EMPATHY COULD BETTER ENABLE ARMY LEADERS TO WIN A thesis presented to the...Leaders to Win 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Matthew J. Fontaine, MAJ 5d. PROJECT NUMBER

  7. Understanding consumer participation in mental health: Issues of power and change. (United States)

    Bennetts, Wanda; Cross, Wendy; Bloomer, Melissa


    Consumer participation occurs in all Victorian public mental health services. Area mental health services employ consumer consultants to enhance consumer participation across the network. Ongoing support of management is essential to the success of consumer participation. This project aimed to explore understandings of consumer participation from a manager's perspective. Semistructured interviews were conducted with seven participants in this qualitative, interpretive study. The thematic analysis revealed the complexities around defining consumer participation and demonstrated the difficulties and possible reasons as to why there is no real clarity between managers, service providers, and consumers as to what consumer participation should look like. Power and change were the primary themes. Power and the overwhelming consensus that the medical model and those working within it hold the most power was strongly represented in this study. Legislation and workplace settings were seen as considerable factors adding to the disempowerment of consumers within an already disempowering mental health system. Change was the other main theme that emerged, with culture and attitudes of the old 'institutionalized' thinking that still pervades some pockets of mental health services being seen as the major barriers to change. The role of the consumer consultant was a prominent subtheme, with their role in training and the education of workers seen as an essential and positive way to progress consumer participation. These findings demonstrate that managers consider there to be hope for consumers, brought about by collective action and lobbying, and through consumer participation in less-restrictive parts of the service (community settings). © 2011 The Authors. International Journal of Mental Health Nursing © 2011 Australian College of Mental Health Nurses Inc.

  8. Complexity Triggered by Economic Globalisation— The Issue of On-Line Betting-Related Match Fixing

    Directory of Open Access Journals (Sweden)

    Wladimir Andreff


    Full Text Available Complexity in mainstream economics consists in high intermediary consumption of mathematics. A new approach to complexity economics dwells upon path-dependent global systems; their emergence and evolving organisation. The focus here is on the complexity of the real economic world due to globalisation. On-line betting related match-fixing is a case in point about which the article presents non-exhaustive empirical evidence and shows how it is analysed with the standard model of the economics of crime. There is no room for complexity in such an individualistic approach to corrupt behaviour applied to bet-related fixes. A more complex model is sketched based on interactions between a global (though underground market for fixes and the actual partly legal, partly illegal global sport betting market. These interactions exhibit how complex is the issue of combating betting-related match fixing. Reviewing those major policies envisaged for containing the latter—prohibition; sanctions; regulation; privatisation (betting rights—the article opts for a global ‘Sportbettobin’ tax on sport betting gains; in the same vein as the famous Tobin tax on international capital transfers. The novelty in this approach is a variable (increasing rate applied to increasing tranches of taxation (gains which should dry up the worst cases of on-line bettingrelated match fixing.

  9. Furthering better communication and understanding of nuclear issues through public education: a public school teacher's perspective

    International Nuclear Information System (INIS)

    Danfelser, M.


    Recent reports of national commissions and study groups have pointed out that the American educational system is not meeting the needs of its students. Uniformly, the reports call for a new instructional focus designed to achieve the goal of ''universal scientific and technological literacy for citizenship.'' The population's inability to deal with numerous controversial science-related social issues forms the basis for this call for educational reform. Foremost on the list of science-related social issues are nuclear issues in general and the storage of nuclear waste in particular. The National Council for the Social Studies (NCSS) 1983 publication ''Guidelines for Teaching Science Related Social Issues'' was designed to encourage stronger instructional emphasis on science-related social issues, and to provide social studies teachers with a rational and structure for the presentation of the issues. This paper discusses the dilemmas faced by educators who attempt to deal with science-related social issues. Also, it addresses the need for instructional materials in order to effectively address nuclear issues in the classroom

  10. Understanding Key Education Issues: How We Got Here and Where We Go from Here (United States)

    Lynch, Matthew


    In this age of education innovation and reform, schools must evolve and react to current policy trends. This accessible book offers research-based insights into six key educational trends and issues that are impacting K-12 learning today: year-round schooling, assessments, educating minorities, anti-intellectualism, issues of social promotion and…

  11. Preservice Teachers Develop an Understanding of Diversity Issues through Multicultural Literature (United States)

    Jetton, Tamara L.; Savage-Davis, Emma M.


    This article explores issues of multicultural education and diversity. The authors present a preservice teacher education program that uses multicultural literature to prepare young teachers to better serve their students. The authors discuss the curriculum design of the program to help preservice teachers become more sensitive to the issues of…

  12. Fort Collins Science Center Ecosystem Dynamics branch--interdisciplinary research for addressing complex natural resource issues across landscapes and time (United States)

    Bowen, Zachary H.; Melcher, Cynthia P.; Wilson, Juliette T.


    The Ecosystem Dynamics Branch of the Fort Collins Science Center offers an interdisciplinary team of talented and creative scientists with expertise in biology, botany, ecology, geology, biogeochemistry, physical sciences, geographic information systems, and remote-sensing, for tackling complex questions about natural resources. As demand for natural resources increases, the issues facing natural resource managers, planners, policy makers, industry, and private landowners are increasing in spatial and temporal scope, often involving entire regions, multiple jurisdictions, and long timeframes. Needs for addressing these issues include (1) a better understanding of biotic and abiotic ecosystem components and their complex interactions; (2) the ability to easily monitor, assess, and visualize the spatially complex movements of animals, plants, water, and elements across highly variable landscapes; and (3) the techniques for accurately predicting both immediate and long-term responses of system components to natural and human-caused change. The overall objectives of our research are to provide the knowledge, tools, and techniques needed by the U.S. Department of the Interior, state agencies, and other stakeholders in their endeavors to meet the demand for natural resources while conserving biodiversity and ecosystem services. Ecosystem Dynamics scientists use field and laboratory research, data assimilation, and ecological modeling to understand ecosystem patterns, trends, and mechanistic processes. This information is used to predict the outcomes of changes imposed on species, habitats, landscapes, and climate across spatiotemporal scales. The products we develop include conceptual models to illustrate system structure and processes; regional baseline and integrated assessments; predictive spatial and mathematical models; literature syntheses; and frameworks or protocols for improved ecosystem monitoring, adaptive management, and program evaluation. The descriptions

  13. Argumentation as a Strategy for Increasing Preservice Teachers' Understanding of Climate Change, a Key Global Socioscientific Issue (United States)

    Lambert, Julie L.; Bleicher, Robert E.


    Findings of this study suggest that scientific argumentation can play an effective role in addressing complex socioscientific issues (i.e. global climate change). This research examined changes in preservice teachers' knowledge and perceptions about climate change in an innovative undergraduate-level elementary science methods course. The…

  14. OI Issues: Type I - Understanding the Mildest Form of Osteogenesis Imperfecta (United States)

    ... Flu shots and pneumonia vaccines are often recommended. Social, Emotional, and Family Issues Many people with OI ... Miembro Activo del Equipo de Cuidados de la Salud (FDA) Home Bone Basics Osteoporosis Osteogenesis Imperfecta Paget’s ...

  15. Speech Understanding in Complex Listening Environments by Listeners Fit with Cochlear Implants (United States)

    Dorman, Michael F.; Gifford, Rene H.


    Purpose: The aim of this article is to summarize recent published and unpublished research from our 2 laboratories on improving speech understanding in complex listening environments by listeners fit with cochlear implants (CIs). Method: CI listeners were tested in 2 listening environments. One was a simulation of a restaurant with multiple,…


    International Nuclear Information System (INIS)



    Although DOE's Environmental Management program has made steady progress in cleaning up environmental legacies throughout the DOE complex, there are still significant remediation issues that remain to be solved. For example, DOE faces difficult challenges related to potential mobilization of radionuclides (e.g., actinides) and other hazardous contaminants in soils, removal and final treatment of high-level waste and residuals from leaking tanks, and the long-term stewardship of remediated sites and engineered disposal facilities, to name just a few. In some cases, new technologies and technology applications will be required based on current engineering expertise. In others, however, basic scientific research is needed to understand the mechanisms of how contaminants behave under specific conditions and how they interact with the environment, from which new engineering solutions can emerge. At Brookhaven National Laboratory (BNL) and Stony Brook University, scientists have teamed to use state-of-the-art synchrotron techniques to help understand the basic interactions of contaminants in the environment. Much of this work is conducted at the BNL National Synchrotron Light Source (NSLS), which is a user facility that provides high energy X-ray and ultraviolet photon beams to facilitate the examination of contaminants and materials at the molecular level. These studies allow us to determine how chemical speciation and structure control important parameters such as solubility, which in turn drive critical performance characteristics such as leaching. In one study for example, we are examining the effects of microbial activity on actinide contaminants under conditions anticipated at the Waste Isolation Pilot Plant. One possible outcome of this research is the identification of specific microbes that can trap uranium or other contaminants within the intracellular structure and help mitigate mobility. In another study, we are exploring the interaction of contaminants with

  17. Why more is different philosophical issues in condensed matter physics and complex systems

    CERN Document Server

    Morrison, Margaret


    The physics of condensed matter, in contrast to quantum physics or cosmology, is not traditionally associated with deep philosophical questions. However, as science - largely thanks to more powerful computers - becomes capable of analysing and modelling ever more complex many-body systems, basic questions of philosophical relevance arise. Questions about the emergence of structure, the nature of cooperative behaviour, the implications of the second law,  the quantum-classical transition and many other issues. This book is a collection of essays by leading physicists and philosophers. Each investigates one or more of these issues, making use of examples from modern condensed matter research.  Physicists and philosophers alike will find surprising and stimulating ideas in these pages.

  18. Understanding Campus Culture and Student Coping Strategies for Mental Health Issues in Five Canadian Colleges and Universities (United States)

    Giamos, Dimitris; Lee, Alex Young Soo; Suleiman, Amanda; Stuart, Heather; Chen, Shu-Ping


    This study aimed to better understand campus mental health culture and student mental health coping strategies, and to identify the mental health needs of students as well as gaps in mental health services within postsecondary education. A videovoice method was used to identify and document health-related issues and advocate for change. Forty-one…

  19. Students' Participation in an Interdisciplinary, Socioscientific Issues Based Undergraduate Human Biology Major and Their Understanding of Scientific Inquiry (United States)

    Eastwood, Jennifer L.; Sadler, Troy D.; Sherwood, Robert D.; Schlegel, Whitney M.


    The purpose of this study was to examine whether Socioscientific Issues (SSI) based learning environments affect university students' epistemological understanding of scientific inquiry differently from traditional science educational contexts. We identify and compare conceptions of scientific inquiry of students participating in an…

  20. Empowering Youth to Think and Act Critically About Complex Climate Issues (United States)

    Harden, L.; Michelson, M.; Schufreider, M.; Babcock, E.; Klotz-Chamberlin, R.; Bagley, E.; Cassidy, E. S.; Levedahl, K.; Perez, N.; Vanderbilt, C.; Hammond, K.; Brutus, D.; Arrowsmith, T.


    The world is facing complex environmental challenges and a changing climate is one of the most pressing. These challenges require innovative solutions, which can only be achieved by first developing a more science and environmentally literate public through high-quality education. We know a lot about how to frame climate change messages to be most effective for adults (1). However, we know much less about how youth respond to these same messages. It is important to engage adolescents in these conversations, as this is the age when kids begin to think more critically and abstractly about complex problems, but also when peer and social influences increase in importance (2). Thus, middle school is a critical point in young students' lives when they might either lose interest in science or gain a strong science identity. To keep them interested and invested in science and environmental issues, we need relevant and transformative climate change materials for use in the classroom—materials that are video-based, compelling, and presented by other youth. The California Academy of Sciences has developed a video-based series with lessons supporting the NGSS called Flipside Science that challenges youth to think critically about complex environmental issues. Exploring Energy: Designing a Brighter Future is a unit within this series that engages youth in thinking about how we can make changes to our current energy uses and behaviors to combat climate change. The videos in the unit are hosted by diverse teens who bring an optimistic and relevant voice to these issues, and the associated lessons engage students in honing their design thinking and problem-solving skills. Although intended for use inside the classroom, these resources inspire action among youth outside of the classroom and in their communities. Initial evaluations of two other Flipside Science units on water and food issues indicate that the youth-powered nature of the videos and the real-world challenges posed

  1. An argumentation-based method for managing complex issues in design of infrastructural systems

    International Nuclear Information System (INIS)

    Marashi, Emad; Davis, John P.


    The many interacting and conflicting requirements of a wide range of stakeholders are the main sources of complexity in the infrastructure and utility systems. We propose a systemic methodology based on negotiation and argumentation to help in the resolution of complex issues and to facilitate options appraisal during design of such systems. A process-based approach is used to assemble and propagate the evidence on performance and reliability of the system and its components, providing a success measure for different scenarios or design alternatives. The reliability of information sources and experts opinions are dealt with through an extension of the mathematical theory of evidence. This framework helps not only in capturing the reasoning behind design decisions, but also enables the decision-makers to assess and compare the evidential support for each design option

  2. Understanding the implementation of complex interventions in health care: the normalization process model

    Directory of Open Access Journals (Sweden)

    Rogers Anne


    Full Text Available Abstract Background The Normalization Process Model is a theoretical model that assists in explaining the processes by which complex interventions become routinely embedded in health care practice. It offers a framework for process evaluation and also for comparative studies of complex interventions. It focuses on the factors that promote or inhibit the routine embedding of complex interventions in health care practice. Methods A formal theory structure is used to define the model, and its internal causal relations and mechanisms. The model is broken down to show that it is consistent and adequate in generating accurate description, systematic explanation, and the production of rational knowledge claims about the workability and integration of complex interventions. Results The model explains the normalization of complex interventions by reference to four factors demonstrated to promote or inhibit the operationalization and embedding of complex interventions (interactional workability, relational integration, skill-set workability, and contextual integration. Conclusion The model is consistent and adequate. Repeated calls for theoretically sound process evaluations in randomized controlled trials of complex interventions, and policy-makers who call for a proper understanding of implementation processes, emphasize the value of conceptual tools like the Normalization Process Model.

  3. Understanding "Great Expectations": A Student Casebook to Issues, Sources, and Historical Documents. (United States)

    Newlin, George

    More than 100 years after being written, "Great Expectations" is still one of the most widely studied works of fiction. This casebook of historical documents, collateral readings and essays brings to life both Charles Dickens' masterpiece and the social issues surrounding his work. The interdisciplinary approach in the casebook offers…

  4. Understanding "The Merchant of Venice": A Student Casebook to Issues, Sources, and Historical Documents. (United States)

    Halio, Jay L.

    "The Merchant of Venice," even in its own time, was considered William Shakespeare's most controversial play. Now, one of the most popular read and performed works, the play raises even more important issues for today, particularly anti-Semitism and the treatment of Jews. The analysis of the play in this casebook helps students interpret…

  5. The Interface of Opinion, Understanding and Evaluation While Learning about a Socioscientific Issue (United States)

    Witzig, Stephen B.; Halverson, Kristy L.; Siegel, Marcelle A.; Freyermuth, Sharyn K.


    Scientific literacy is an important goal for science education, especially within controversial socioscientific issues. In this study, we analysed 143 students' research reports about stem cell research (SCR) for how they addressed specific source evaluation criteria provided within the assignment. We investigated students' opinions about SCR, how…

  6. Understanding Nuclear Weapons and Arms Control: A Guide to the Issues. New Edition. (United States)

    Mayers, Teena

    Intended for secondary and college level students and teachers, this guide discusses the nuclear arms control issue. There are four sections. Section I discusses U.S. nuclear strategy from 1945 to the present, strategic nuclear weapons competition between the United States and the Union of Soviet Socialist Republics (U.S.S.R.), U.S.…

  7. Industry Issue Paper: Understanding the Shared Operation of Commuter Rail Transit and Freight Railroads


    Liu, Rongfang; Yang, Fei; Chen, Mei


    Seeking a thorough understanding of shared operation between commuter rail transit and freight railroads, a nationwide survey was conducted of transit and rail freight interaction. This survey contacted and received responses from all 21 commuter rail services in North America. In addition to a general understanding of the shared-use practices, this paper presents the key factors that contribute or impede successful shared-use operations between commuter rail and freight railroads by examinin...

  8. Military Suicide: Developing an Understanding of Basic Issues to Provide a Lower Risk Force (United States)

    prevention programs may not fully address the underlying mental health issues associated with the young adult population. As a result, the services may be inadvertently recruiting service members with increased risk....preventing suicides for currently serving service members. An exploration of available research and demographic data identifies specific...populations present specific trends in behavior and demographics that lead to suicidal behaviors. The research suggests that a significant proportion

  9. Understanding the dimensions of intensive care: transpersonal caring and complexity theories. (United States)

    do Nascimento, Keyla Cristiane; Erdmann, Alacoque Lorenzini


    This is a descriptive, interpretive and qualitative study carried out at the ICU of a Brazilian teaching hospital. It aimed to understand the dimensions of human caring experienced by health care professionals, clients and their family members at an ICU, based on human caring complexity. The Transpersonal Caring and Complexity theories support theory and data analysis. The following dimensions of care emerged from the themes analyzed according to Ricoeur: self-care, care as an individual value, professional vs. informal care, care as supportive relationship, affective care, humanized care, care as act/attitude, care practice; educative care, dialogical relationship, care coupled to technology, loving care, interactive care, non-care, care ambience, the essence of life and profession, and meaning/purpose of care. We believe in care that encompasses several dimensions presented here, based on the relationship with the other, on the empathetic, sensitive, affectionate, creative, dynamic and understanding being in the totality of the human being.

  10. Issues In-Depth: Advancing Understanding of Drug Addiction and Treatment (United States)

    Miller, Roxanne Greitz


    While most school districts utilize a drug abuse resistance curriculum, as science teachers, it is our responsibility to understand the science behind drug addiction in order to most effectively educate our students against drug abuse. In the last two decades, increases in scientific technology have permitted significant discoveries surrounding…

  11. Understanding Shakespeare's "Julius Caesar" Online: A Student Casebook to Issues, Sources, and Historical Documents. (United States)

    Derrick, Thomas

    This casebook of materials about William Shakespeare's "Julius Caesar" will enrich students' understanding of the historical context of the play and encourage interpretations of its cultural meaning. Shakespeare's "Julius Caesar" reflects perennial cultural concerns about order and freedom, particularly as they clash in the…

  12. A Phenomenological Study: Understanding the Management of Social Categorization Diversity Issues Associated with College Athletic Teams (United States)

    Dickelman, Eric


    This qualitative phenomenological research study explored the social categorization diversity management experiences of NCAA Division I, II and III athletic coaches. The research study used a combination of questionnaire, observation and coaching interviews to obtain an understanding of the skills, tools and techniques that these coaches used to…

  13. Toward understanding the thermodynamics of TALSPEAK process. Medium effects on actinide complexation

    Energy Technology Data Exchange (ETDEWEB)

    Peter R Zalupski; Leigh R Martin; Ken Nash; Yoshinobu Nakamura; Masahiko Yamamoto


    The ingenious combination of lactate and diethylenetriamine-N,N,N’,N”,N”-pentaacetic acid (DTPA) as an aqueous actinide-complexing medium forms the basis of the successful separation of americium and curium from lanthanides known as the TALSPEAK process. While numerous reports in the prior literature have focused on the optimization of this solvent extraction system, considerably less attention has been devoted to the understanding of the basic thermodynamic features of the complex fluids responsible for the separation. The available thermochemical information of both lactate and DTPA protonation and metal complexation reactions are representative of the behavior of these ions under idealized conditions. Our previous studies of medium effects on lactate protonation suggest that significant departures from the speciation predicted based on reported thermodynamic values should be expected in the TALSPEAK aqueous environment. Thermodynamic parameters describing the separation chemistry of this process thus require further examination at conditions significantly removed from conventional ideal systems commonly employed in fundamental solution chemistry. Such thermodynamic characterization is the key to predictive modelling of TALSPEAK. Improved understanding will, in principle, allow process technologists to more efficiently respond to off-normal conditions during large scale process operation. In this report, the results of calorimetric and potentiometric investigations of the effects of aqueous electrolytes on the thermodynamic parameters for lactate protonation and lactate complexation of americium and neodymium will be presented. Studies on the lactate protonation equilibrium will clearly illustrate distinct thermodynamic variations between strong electrolyte aqueous systems and buffered lactate environment.

  14. Introduction to the Special Issue: Ungulates and invasive species: quantifying impacts and understanding interactions. (United States)

    Blossey, Bernd; Gorchov, David L


    White-tailed deer are emblematic ungulates that, due to anthropogenic modification of landscapes, currently occur at elevated densities. Elevated deer densities often co-occur with non-native plants, but it is not known if plant invasions are a consequence of deer impacts or occur independent of deer impacts on ecosystems, or whether these two stressors are synergistic. A colloquium on 'Interactions of white-tailed deer and invasive plants in forests of eastern North America' explored these topics at the 2016 annual meeting of the Botanical Society of America. Nine of those presentations are published in this special issue of AoB PLANTS .

  15. Understanding the GPCR biased signaling through G protein and arrestin complex structures. (United States)

    Zhou, X Edward; Melcher, Karsten; Xu, H Eric


    G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors and are important drug targets for many human diseases. The determination of the 3-D structure of GPCRs and their signaling complexes has promoted our understanding of GPCR biology and provided templates for structure-based drug discovery. In this review, we focus on the recent structure work on GPCR signaling complexes, the β2-adrenoreceptor-Gs and the rhodopsin-arrestin complexes in particular, and highlight the structural features of GPCR complexes involved in G protein- and arrestin-mediated signal transduction. The crystal structures reveal distinct structural mechanisms by which GPCRs recruit a G protein and an arrestin. A comparison of the two complex structures provides insight into the molecular mechanism of functionally selective GPCR signaling, and a structural basis for the discovery of G protein- and arrestin-biased treatments of human diseases related to GPCR signal transduction. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. A Diagrammatic Approach to Understanding Complex Eco-Social Interactions in Kathmandu, Nepal

    Directory of Open Access Journals (Sweden)

    R. Cynthia. Neudoerffer


    Full Text Available As part of developing an international network of community-based ecosystem approaches to health, a project was undertaken in a densely populated and socio-economically diverse area of Kathmandu, Nepal. Drawing on hundreds of pages of narrative reports based on surveys, interviews, secondary data, and focus groups by trained Nepalese facilitators, the authors created systemic depictions of relationships between multiple stakeholder groups, ecosystem health, and human health. These were then combined to examine interactions among stakeholders, activities, concerns, perceived needs, and resource states (ecosystem health indicators. These qualitative models have provided useful heuristics for both community members and research scholars to understand the eco-social systems in which they live; many of the strategies developed by the communities and researchers to improve health intuitively drew on this systemic understanding. The diagrams enabled researchers and community participants to explicitly examine relationships and conflicts related to health and environmental issues in their community.

  17. Food, health, and complexity: towards a conceptual understanding to guide collaborative public health action

    Directory of Open Access Journals (Sweden)

    Shannon E. Majowicz


    Full Text Available Abstract Background What we eat simultaneously impacts our exposure to pathogens, allergens, and contaminants, our nutritional status and body composition, our risks for and the progression of chronic diseases, and other outcomes. Furthermore, what we eat is influenced by a complex web of drivers, including culture, politics, economics, and our built and natural environments. To date, public health initiatives aimed at improving food-related population health outcomes have primarily been developed within ‘practice silos’, and the potential for complex interactions among such initiatives is not well understood. Therefore, our objective was to develop a conceptual model depicting how infectious foodborne illness, food insecurity, dietary contaminants, obesity, and food allergy can be linked via shared drivers, to illustrate potential complex interactions and support future collaboration across public health practice silos. Methods We developed the conceptual model by first conducting a systematic literature search to identify review articles containing schematics that depicted relationships between drivers and the issues of interest. Next, we synthesized drivers into a common model using a modified thematic synthesis approach that combined an inductive thematic analysis and mapping to synthesize findings. Results The literature search yielded 83 relevant references containing 101 schematics. The conceptual model contained 49 shared drivers and 227 interconnections. Each of the five issues was connected to all others. Obesity and food insecurity shared the most drivers (n = 28. Obesity shared several drivers with food allergy (n = 11, infectious foodborne illness (n = 7, and dietary contamination (n = 6. Food insecurity shared several drivers with infectious foodborne illness (n = 9 and dietary contamination (n = 9. Infectious foodborne illness shared drivers with dietary contamination (n = 8. Fewer drivers were

  18. Brand names of Portuguese medication: understanding the importance of their linguistic structure and regulatory issues. (United States)

    Pires, Carla; Vigário, Marina; Cavaco, Afonso


    Among other regulatory requirements, medicine brands should be composed of single names without abbreviations to prevent errors in prescription of medication. The purposes of the study were to investigate the compliance of a sam ple of Portuguese medicine brand names with Portuguese pharmaceutical regulations. This includes identifying their basic linguistic characteristics and comparing these features and their frequency of occurrence with benchmark values of the colloquial or informal language. A sample of 474 brand names was selected. Names were analyzed using manual (visual analyses) and computer methods (FreP - Frequency Patterns of Phonological Objects in Portuguese and MS word). A significant number of names (61.3%) failed to comply with the Portuguese phonologic system (related to the sound of words) and/or the spelling system (related to the written form of words) contained more than one word, comprised a high proportion of infrequent syllable types or stress patterns and included abbreviations. The results suggest that some of the brand names of Portuguese medication should be reevaluated, and that regulation on this issue should be enforced and updated, taking into consideration specific linguistic and spelling codes.

  19. Brand names of Portuguese medication: understanding the importance of their linguistic structure and regulatory issues

    Directory of Open Access Journals (Sweden)

    Carla Pires


    Full Text Available AbstractAmong other regulatory requirements, medicine brands should be composed of single names without abbreviations to prevent errors in prescription of medication. The purposes of the study were to investigate the compliance of a sam ple of Portuguese medicine brand names with Portuguese pharmaceutical regulations. This includes identifying their basic linguistic characteristics and comparing these features and their frequency of occurrence with benchmark values of the colloquial or informal language. A sample of 474 brand names was selected. Names were analyzed using manual (visual analyses and computer methods (FreP - Frequency Patterns of Phonological Objects in Portuguese and MS word. A significant number of names (61.3% failed to comply with the Portuguese phonologic system (related to the sound of words and/or the spelling system (related to the written form of words contained more than one word, comprised a high proportion of infrequent syllable types or stress patterns and included abbreviations. The results suggest that some of the brand names of Portuguese medication should be reevaluated, and that regulation on this issue should be enforced and updated, taking into consideration specific linguistic and spelling codes.

  20. Mediation, moderation, and context: Understanding complex relations among cognition, affect, and health behaviour. (United States)

    Kiviniemi, Marc T; Ellis, Erin M; Hall, Marissa G; Moss, Jennifer L; Lillie, Sarah E; Brewer, Noel T; Klein, William M P


    Researchers have historically treated cognition and affect as separate constructs in motivating health behaviour. We present a framework and empirical evidence for complex relations between cognition and affect in predicting health behaviour. Main Outcome, Design and Results: First, affect and cognition can mediate each other's relation to health behaviour. Second, affect and cognition can moderate the other's impact. Third, context can change the interplay of affect and cognition. Fourth, affect and cognition may be indelibly fused in some psychological constructs (e.g. worry, anticipated regret and reactance). These four propositions in our framework are not mutually exclusive. Examination of the types of complex relations described here can benefit theory development, empirical testing of theories and intervention design. Doing so will advance the understanding of mechanisms involved in regulation of health behaviours and the effectiveness of interventions to change health behaviours.

  1. Understanding valve program complexity in a refurbishment environment - learning from the past

    International Nuclear Information System (INIS)

    Roth, H.E.


    The complexity of Valve Program development, planning, execution and management in a refurbishment environment is an enormous undertaking requiring the proper coordination and integration of many moving parts. As such, lack of attention and understanding of this complexity has led to significant cost and schedule overruns in past refurbishment projects in the province. OPEX indicates the challenges in completing valve scope during refurbishments are related but not limited to; lack of detailed condition assessments, improper scope development, insignificant strategic approach to work task planning, scheduling and procurement, absence of contingency planning for common ‘as found’ conditions during execution, lack of proper training requirements, etc. In addition, past contracting strategies to employ numerous companies in collaboration to complete such a complex and specialized program, has resulted in further complications surrounding the management and integration of multiple quality programs and internal company processes. Finally, the aftermath of such fragmented projects results in an absolute closeout nightmare, often times taking years to locate, sift through and re-integrate pertinent information back into customer systems. Valve Program complexity cannot be understood by just anyone, only those that have lived through a refurbishment project and experienced the challenges mentioned above have the knowledge, skill, and ability to appreciate how to tactically apply past learning to realize future improvements. Furthermore, effective contractor-customer collaboration is crucial; true and in-depth knowledge and understanding of the customer quality programs, engineering and work management processes, configuration management requirements, and most importantly the imperative significance of nuclear safety, are all essential components to ensure overall alignment and program success. (author)

  2. Understanding, creating, and managing complex techno-socio-economic systems: Challenges and perspectives (United States)

    Helbing, D.; Balietti, S.; Bishop, S.; Lukowicz, P.


    This contribution reflects on the comments of Peter Allen [1], Bikas K. Chakrabarti [2], Péter Érdi [3], Juval Portugali [4], Sorin Solomon [5], and Stefan Thurner [6] on three White Papers (WP) of the EU Support Action Visioneer ( These White Papers are entitled "From Social Data Mining to Forecasting Socio-Economic Crises" (WP 1) [7], "From Social Simulation to Integrative System Design" (WP 2) [8], and "How to Create an Innovation Accelerator" (WP 3) [9]. In our reflections, the need and feasibility of a "Knowledge Accelerator" is further substantiated by fundamental considerations and recent events around the globe. newpara The Visioneer White Papers propose research to be carried out that will improve our understanding of complex techno-socio-economic systems and their interaction with the environment. Thereby, they aim to stimulate multi-disciplinary collaborations between ICT, the social sciences, and complexity science. Moreover, they suggest combining the potential of massive real-time data, theoretical models, large-scale computer simulations and participatory online platforms. By doing so, it would become possible to explore various futures and to expand the limits of human imagination when it comes to the assessment of the often counter-intuitive behavior of these complex techno-socio-economic-environmental systems. In this contribution, we also highlight the importance of a pluralistic modeling approach and, in particular, the need for a fruitful interaction between quantitative and qualitative research approaches. newpara In an appendix we briefly summarize the concept of the FuturICT flagship project, which will build on and go beyond the proposals made by the Visioneer White Papers. EU flagships are ambitious multi-disciplinary high-risk projects with a duration of at least 10 years amounting to an envisaged overall budget of 1 billion EUR [10]. The goal of the FuturICT flagship initiative is to understand and manage complex

  3. Toward understanding the thermodynamics of TALSPEAK process. Medium effects on actinide complexation

    International Nuclear Information System (INIS)

    Zalupski, Peter R.; Martin, Leigh R.; Nash, Ken; Nakamura, Yoshinobu; Yamamoto, Masahiko


    The ingenious combination of lactate and diethylenetriamine-N,N,N',N(double p rime),N(double p rime)-pentaacetic acid (DTPA) as an aqueous actinide-complexing medium forms the basis of the successful separation of americium and curium from lanthanides known as the TALSPEAK process. While numerous reports in the prior literature have focused on the optimization of this solvent extraction system, considerably less attention has been devoted to the understanding of the basic thermodynamic features of the complex fluids responsible for the separation. The available thermochemical information of both lactate and DTPA protonation and metal complexation reactions are representative of the behavior of these ions under idealized conditions. Our previous studies of medium effects on lactate protonation suggest that significant departures from the speciation predicted based on reported thermodynamic values should be expected in the TALSPEAK aqueous environment. Thermodynamic parameters describing the separation chemistry of this process thus require further examination at conditions significantly removed from conventional ideal systems commonly employed in fundamental solution chemistry. Such thermodynamic characterization is the key to predictive modelling of TALSPEAK. Improved understanding will, in principle, allow process technologists to more efficiently respond to off-normal conditions during large scale process operation. In this report, the results of calorimetric and potentiometric investigations of the effects of aqueous electrolytes on the thermodynamic parameters for lactate protonation and lactate complexation of americium and neodymium will be presented. Studies on the lactate protonation equilibrium will clearly illustrate distinct thermodynamic variations between strong electrolyte aqueous systems and buffered lactate environment.

  4. Understanding and Mitigating Multicore Performance Issues on theAMD Opteron Architecture

    Energy Technology Data Exchange (ETDEWEB)

    Levesque, John; Larkin, Jeff; Foster, Martyn; Glenski, Joe; Geissler, Garry; Whalen, Stephen; Waldecker, Brian; Carter, Jonathan; Skinner, David; He, Helen; Wasserman, Harvey; Shalf, John; Shan,Hongzhang; Strohmaier, Erich


    Over the past 15 years, microprocessor performance hasdoubled approximately every 18 months through increased clock rates andprocessing efficiency. In the past few years, clock frequency growth hasstalled, and microprocessor manufacturers such as AMD have moved towardsdoubling the number of cores every 18 months in order to maintainhistorical growth rates in chip performance. This document investigatesthe ramifications of multicore processor technology on the new Cray XT4?systems based on AMD processor technology. We begin by walking throughthe AMD single-core and dual-core and upcoming quad-core processorarchitectures. This is followed by a discussion of methods for collectingperformance counter data to understand code performance on the Cray XT3?and XT4? systems. We then use the performance counter data to analyze theimpact of multicore processors on the performance of microbenchmarks suchas STREAM, application kernels such as the NAS Parallel Benchmarks, andfull application codes that comprise the NERSC-5 SSP benchmark suite. Weexplore compiler options and software optimization techniques that canmitigate the memory bandwidth contention that can reduce computingefficiency on multicore processors. The last section provides a casestudy of applying the dual-core optimizations to the NAS ParallelBenchmarks to dramatically improve their performance.

  5. Preservice special education teachers' understandings, enactments, views, and plans for scientific inquiry: Issues and hopes (United States)

    Ghosh, Rajlakshmi

    This study examined the understandings, enactments, views, and plans for scientific inquiry held by preservice special education teachers enrolled in a K--8 general science methods course. Sixteen participants from four special education concentration areas---Mild to Moderate Educational Needs, Moderate to Intense Educational Needs, Mild to Moderate Educational Needs with Language Arts and Reading Emphasis, and Early Childhood Intervention---participated in this study. Qualitative data were collected from questionnaires, interviews, teaching videos, lesson plans, planning commentaries, and reflection papers. Data were analyzed using a grounded theory approach (Strauss & Corbin, 1990) and compared against the theoretical view of inquiry as conceptualized by the National Research Council (NRC, 2000). The participants held unique interpretations of inquiry that only partially matched with the theoretical insights provided by the NRC. The participants' previous science learning experiences and experiences in special education played an important role in shaping their conceptualizations of inquiry as learned in the science methods class. The impacts of such unique interpretations are discussed with reference to both science education and special education, and implications for teacher education are provided.

  6. A socioecological framework to understand weight-related issues in Aboriginal children in Canada. (United States)

    Willows, Noreen D; Hanley, Anthony J G; Delormier, Treena


    Obesity prevention efforts in Aboriginal (First Nations, Métis, or Inuit) communities in Canada should focus predominantly on children given their demographic significance and the accelerated time course of occurrence of type 2 diabetes mellitus in the Aboriginal population. A socioecological model to address childhood obesity in Aboriginal populations would focus on the numerous environments at different times in childhood that influence weight status, including prenatal, sociocultural, family, and community environments. Importantly, for Aboriginal children, obesity interventions need to also be situated within the context of a history of colonization and inequities in the social determinants of health. This review therefore advocates for the inclusion of a historical perspective and a life-course approach to obesity prevention in Aboriginal children in addition to developing interventions around the socioecological framework. We emphasize that childhood obesity prevention efforts should focus on promoting maternal health behaviours before and during pregnancy, and on breastfeeding and good infant and child nutrition in the postpartum and early childhood development periods. Ameliorating food insecurity by focusing on improving the sociodemographic risk factors for it, such as increasing income and educational attainment, are essential. More research is required to understand and measure obesogenic Aboriginal environments, to examine how altering specific environments modifies the foods that children eat and the activities that they do, and to examine how restoring and rebuilding cultural continuity in Aboriginal communities modifies the many determinants of obesity. This research needs to be done with the full participation of Aboriginal communities as partners in the research.

  7. Using chemistry and microfluidics to understand the spatial dynamics of complex biological networks. (United States)

    Kastrup, Christian J; Runyon, Matthew K; Lucchetta, Elena M; Price, Jessica M; Ismagilov, Rustem F


    Understanding the spatial dynamics of biochemical networks is both fundamentally important for understanding life at the systems level and also has practical implications for medicine, engineering, biology, and chemistry. Studies at the level of individual reactions provide essential information about the function, interactions, and localization of individual molecular species and reactions in a network. However, analyzing the spatial dynamics of complex biochemical networks at this level is difficult. Biochemical networks are nonequilibrium systems containing dozens to hundreds of reactions with nonlinear and time-dependent interactions, and these interactions are influenced by diffusion, flow, and the relative values of state-dependent kinetic parameters. To achieve an overall understanding of the spatial dynamics of a network and the global mechanisms that drive its function, networks must be analyzed as a whole, where all of the components and influential parameters of a network are simultaneously considered. Here, we describe chemical concepts and microfluidic tools developed for network-level investigations of the spatial dynamics of these networks. Modular approaches can be used to simplify these networks by separating them into modules, and simple experimental or computational models can be created by replacing each module with a single reaction. Microfluidics can be used to implement these models as well as to analyze and perturb the complex network itself with spatial control on the micrometer scale. We also describe the application of these network-level approaches to elucidate the mechanisms governing the spatial dynamics of two networkshemostasis (blood clotting) and early patterning of the Drosophila embryo. To investigate the dynamics of the complex network of hemostasis, we simplified the network by using a modular mechanism and created a chemical model based on this mechanism by using microfluidics. Then, we used the mechanism and the model to

  8. A critical review of gender issues in understanding prolonged disability related to musculoskeletal pain: how are they relevant to rehabilitation? (United States)

    Côté, Daniel; Coutu, Marie-France


    The purpose of this critical review is to describe the available theoretical models for understanding the gender issues in prolonged work disability related to persistent musculoskeletal (MSK) pain. A critical literature review was conducted in medicine, health sciences, and social sciences databases (MEDLINE, CINHAL, PsychINFO and SOCINDEX) using specific keywords. After screening titles and abstracts, followed by methodological quality assessment, a total of 55 references were retained for content analysis. Gender issues in disability related to persistent MSK pain show that men and women may experience pain and rehabilitation process in different ways. Three main themes were exftracted and further described: (1) the experience of distrust; (2) the self-identity process; and (3) the domestic strain. Each of these themes has a specific and potentially different impact on men and women, and we report that experiential differences may strongly impact the rehabilitation process and outcomes such as return to work. This critical review provides insight into gender issues in the process of rehabilitation and outcomes such as return to work. We suggest that work and family considerations are the two most important issues in the rehabilitation process and that differences between men and women are likely to occur.

  9. An Approach to Understanding Complex Socio-Economic Impacts and Responses to Climate Disruption in the Chesapeake Bay Region (United States)

    Schaefer, R. K.; Nix, M.; Ihde, A. G.; Paxton, L. J.; Weiss, M.; Simpkins, S.; Fountain, G. H.; APl GAIA Team


    In this paper we describe the application of a proven methodology for modeling the complex social and economic interactions of a system under stress to the regional issues that are tied to global climate disruption. Under the auspices of the GAIA project (, we have investigated simulating the complex interplay between climate, politics, society, industry, and the environment in the Chesapeake Bay Watershed and associated geographic areas of Maryland, Virginia, and Pennsylvania. This Chesapeake Bay simulation draws on interrelated geophysical and climate models to support decision-making analysis about the Bay. In addition to physical models, however, human activity is also incorporated via input and output calculations. For example, policy implications are modeled in relation to business activities surrounding fishing, farming, industry and manufacturing, land development, and tourism. This approach fosters collaboration among subject matter experts to advance a more complete understanding of the regional impacts of climate change. Simulated interactive competition, in which teams of experts are assigned conflicting objectives in a controlled environment, allow for subject exploration which avoids trivial solutions that neglect the possible responses of affected parties. Results include improved planning, the anticipation of areas of conflict or high risk, and the increased likelihood of developing mutually acceptable solutions.

  10. Simulation-based education: understanding the socio-cultural complexity of a surgical training 'boot camp'. (United States)

    Cleland, Jennifer; Walker, Kenneth G; Gale, Michael; Nicol, Laura G


    The focus of simulation-based education (SBE) research has been limited to outcome and effectiveness studies. The effect of social and cultural influences on SBE is unclear and empirical work is lacking. Our objective in this study was to explore and understand the complexity of context and social factors at a surgical boot camp (BC). A rapid ethnographic study, employing the theoretical lenses of complexity and activity theory and Bourdieu's concept of 'capital', to better understand the socio-cultural influences acting upon, and during, two surgical BCs, and their implications for SBE. Over two 4-day BCs held in Scotland, UK, an observer and two preceptors conducted 81 hours of observations, 14 field interviews and 11 formal interviews with faculty members (n = 10, including the lead faculty member, session leaders and junior faculty members) and participants (n = 19 core surgical trainees and early-stage residents). Data collection and inductive analysis for emergent themes proceeded iteratively. This paper focuses on three analytical themes. First, the complexity of the surgical training system and wider health care education context, and how this influenced the development of the BC. Second, participants' views of the BC as a vehicle not just for learning skills but for gaining 'insider information' on how best to progress in surgical training. Finally, the explicit aim of faculty members to use the Scottish Surgical Bootcamp to welcome trainees and residents into the world of surgery, and how this occurred. To the best of our knowledge, this is the first empirical study of a surgical BC that takes a socio-cultural approach to exploring and understanding context, complexities, uncertainties and learning associated with one example of SBE. Our findings suggest that a BC is as much about social and cultural processes as it is about individual, cognitive and acquisitive learning. Acknowledging this explicitly will help those planning similar enterprises and

  11. A reduced complexity discrete particle model for understanding the sediment dynamics of steep upland river confluences (United States)

    Tancock, M. J.; Lane, S. N.; Hardy, R. J.


    There has been a significant amount of research conducted in order to understand the flow fields at natural river confluences. Much of this has been made possible due to advances in the use of Computational Fluid Dynamics (CFD). However, much of this research has been conducted on river confluences with negligible water surface slopes and any understanding of the sediment dynamics is largely implied from the flow fields. Therefore, a key challenge is to understand the flow and sediment dynamics of steep river confluences with dynamic boundaries. Two numerical modelling developments are presented which together are capable of increasing our understanding of the sediment dynamics of steep river confluences. The first is the application of a Height-of-Liquid (HOL) model within a CFD framework to explicitly solve the water surface elevation. This is a time-dependent, multiphase treatment of the fluid dynamics which solves for the change in volume of water and air in each vertical column of the mesh. The second is the development of a reduced complexity discrete particle transport model which uses the change in momentum on a spherical particle to predict the transport paths through the flow field determined from CFD simulations. The performance of the two models is tested using field data from a series of highly dynamic, steep gravel-bed confluences on a braidplain of the Borgne d'Arolla, Switzerland. The HOL model is validated against the water surface elevation and flow velocity data and is demonstrated to provide a reliable representation of the flow field in fast-flowing, supercritical flows. In order to validate the discrete particle model, individual particles were tracked using electronic tacheometry. The model is demonstrated to accurately represent the particle tracks obtained in the field and provides a new methodology to understand the dynamic morphology of braid plains.

  12. Understanding and quantifying cognitive complexity level in mathematical problem solving items

    Directory of Open Access Journals (Sweden)



    Full Text Available The linear logistic test model (LLTM; Fischer, 1973 has been applied to a wide variety of new tests. When the LLTM application involves item complexity variables that are both theoretically interesting and empirically supported, several advantages can result. These advantages include elaborating construct validity at the item level, defining variables for test design, predicting parameters of new items, item banking by sources of complexity and providing a basis for item design and item generation. However, despite the many advantages of applying LLTM to test items, it has been applied less often to understand the sources of complexity for large-scale operational test items. Instead, previously calibrated item parameters are modeled using regression techniques because raw item response data often cannot be made available. In the current study, both LLTM and regression modeling are applied to mathematical problem solving items from a widely used test. The findings from the two methods are compared and contrasted for their implications for continued development of ability and achievement tests based on mathematical problem solving items.

  13. Applying a complex adaptive system's understanding of health to primary care [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Johannes Bircher


    Full Text Available This paper explores the diagnostic and therapeutic potential of a new concept of health. Investigations into the nature of health have led to a new definition that explains health as a complex adaptive system (CAS and is based on five components (a-e. Humans like all biological creatures must satisfactorily respond to (a the demands of life. For this purpose they need (b a biologically given potential (BGP and (c a personally acquired potential (PAP. These properties of individuals are embedded within (d social and (e environmental determinants of health. Between these five components of health there are 10 complex interactions that justify viewing health as a CAS. In each patient, the current state of health as a CAS evolved from the past, will move forward to a new future, and has to be analyzed and treated as an autonomous whole. A diagnostic procedure is suggested as follows: together with the patient, the five components and 10 complex interactions are assessed. This may help patients to better understand their situations and to recognize possible next steps that may be useful in order to evolve toward better health by themselves. In this process mutual trust in the patient-physician interaction is critical. The described approach offers new possibilities for helping patients improve their health prospects.

  14. Using a complex adaptive system lens to understand family caregiving experiences navigating the stroke rehabilitation system. (United States)

    Ghazzawi, Andrea; Kuziemsky, Craig; O'Sullivan, Tracey


    Family caregivers provide the stroke survivor with social support and continuity during the transition home from a rehabilitation facility. In this exploratory study we examined family caregivers' perceptions and experiences navigating the stroke rehabilitation system. The theories of continuity of care and complex adaptive systems were integrated to examine the transition from a stroke rehabilitation facility to the patient's home. This study provides an understanding of the interacting complexities at the macro and micro levels. A convenient sample of family caregivers (n = 14) who provide care for a stroke survivor were recruited 4-12 weeks following the patient's discharge from a stroke rehabilitation facility in Ontario, Canada. Interviews were conducted with family caregivers to examine their perceptions and experiences navigating the stroke rehabilitation system. Directed and inductive content analysis and the theory of Complex Adaptive Systems were used to interpret the perceptions of family caregivers. Health system policies and procedures at the macro-level determined the types and timing of information being provided to caregivers, and impacted continuity of care and access to supports and services at the micro-level. Supports and services in the community, such as outpatient physiotherapy services, were limited or did not meet the specific needs of the stroke survivors or family caregivers. Relationships with health providers, informational support, and continuity in case management all influence the family caregiving experience and ultimately the quality of care for the stroke survivor, during the transition home from a rehabilitation facility.

  15. Introduction to the JPA special issue: Can the Psychodynamic Diagnostic Manual put the complex person back at the center-stage of personality assessment? (United States)

    Huprich, Steven K; Meyer, Gregory J


    We briefly introduce this special issue, which focuses both on the Psychodynamic Diagnostic Manual (PDM) and the practice of idiographic, depth-oriented personality assessment. The 7 articles in this issue are diverse in scope but all address these 2 important topics. To set the stage, the special issue opens with a description of the history behind, the purposes of, and the steps taken to develop the PDM, and the next article provides a compelling illustration of depth-oriented personality assessment in the context of a long-term course of psychodynamic treatment. The third and fourth articles describe how the PDM model fosters attention to dynamic processes, not just overt symptoms, and they articulate the challenges and benefits of integrating this model into both the revitalized practice of assessment and diagnosis and the research avenues that will evaluate its validity and utility. The fifth article provides a broad overview of interesting experimental research on implicit processes from personality, social, and cognitive psychology, with implications for understanding and assessing dynamic processes. The sixth article illustrates how a PDM-based assessment of an adolescent boy helpfully contributed to his psychodynamic therapy. Finally, the issue closes with an illuminating article describing a PDM-based training model for the graduated development of assessment and diagnosis skills in a doctoral program. Overall, this special issue helps show how the PDM can invigorate multimethod personality assessment by placing the complex idiographic understanding of a person at the center-stage in the assessment process.

  16. The Crucible simulation: Behavioral simulation improves clinical leadership skills and understanding of complex health policy change. (United States)

    Cohen, Daniel; Vlaev, Ivo; McMahon, Laurie; Harvey, Sarah; Mitchell, Andy; Borovoi, Leah; Darzi, Ara


    The Health and Social Care Act 2012 represents the most complex National Health Service reforms in history. High-quality clinical leadership is important for successful implementation of health service reform. However, little is known about the effectiveness of current leadership training. This study describes the use of a behavioral simulation to improve the knowledge and leadership of a cohort of medical doctors expected to take leadership roles in the National Health Service. A day-long behavioral simulation (The Crucible) was developed and run based on a fictitious but realistic health economy. Participants completed pre- and postsimulation questionnaires generating qualitative and quantitative data. Leadership skills, knowledge, and behavior change processes described by the "theory of planned behavior" were self-assessed pre- and postsimulation. Sixty-nine medical doctors attended. Participants deemed the simulation immersive and relevant. Significant improvements were shown in perceived knowledge, capability, attitudes, subjective norms, intentions, and leadership competency following the program. Nearly one third of participants reported that they had implemented knowledge and skills from the simulation into practice within 4 weeks. This study systematically demonstrates the effectiveness of behavioral simulation for clinical management training and understanding of health policy reform. Potential future uses and strategies for analysis are discussed. High-quality care requires understanding of health systems and strong leadership. Policymakers should consider the use of behavioral simulation to improve understanding of health service reform and development of leadership skills in clinicians, who readily adopt skills from simulation into everyday practice.

  17. Understanding Unintended Consequences and Health Information Technology:. Contribution from the IMIA Organizational and Social Issues Working Group. (United States)

    Kuziemsky, C E; Randell, R; Borycki, E M


    No framework exists to identify and study unintended consequences (UICs) with a focus on organizational and social issues (OSIs). To address this shortcoming, we conducted a literature review to develop a framework for considering UICs and health information technology (HIT) from the perspective of OSIs. A literature review was conducted for the period 2000- 2015 using the search terms "unintended consequences" and "health information technology". 67 papers were screened, of which 18 met inclusion criteria. Data extraction was focused on the types of technologies studied, types of UICs identified, and methods of data collection and analysis used. A thematic analysis was used to identify themes related to UICs. We identified two overarching themes. One was the definition and terminology of how people classify and discuss UICs. Second was OSIs and UICs. For the OSI theme, we also identified four sub-themes: process change and evolution, individual-collaborative interchange, context of use, and approaches to model, study, and understand UICs. While there is a wide body of research on UICs, there is a lack of overall consensus on how they should be classified and reported, limiting our ability to understand the implications of UICs and how to manage them. More mixed-methods research and better proactive identification of UICs remain priorities. Our findings and framework of OSI considerations for studying UICs and HIT extend existing work on HIT and UICs by focusing on organizational and social issues.

  18. More Perspectives, New Politics, New Life: How a Small Group UsedThe Integral Process For Working On Complex Issues


    Sara Ross


    This article reports on a small research project with citizens who wanted to address their community’s chronically adversarial behaviors and atmosphere. It complements a longer research report on the same project, which is also published in this issue of Integral Review. The project used a structured public discourse process, The Integral Process For Working On Complex Issues (TIP). This article supplies background on TIP’s origins, then focuses on two areas. First, it explains the process st...

  19. Using cognitive architectures to study issues in team cognition in a complex task environment (United States)

    Smart, Paul R.; Sycara, Katia; Tang, Yuqing


    Cognitive social simulation is a computer simulation technique that aims to improve our understanding of the dynamics of socially-situated and socially-distributed cognition. This makes cognitive social simulation techniques particularly appealing as a means to undertake experiments into team cognition. The current paper reports on the results of an ongoing effort to develop a cognitive social simulation capability that can be used to undertake studies into team cognition using the ACT-R cognitive architecture. This capability is intended to support simulation experiments using a team-based problem solving task, which has been used to explore the effect of different organizational environments on collective problem solving performance. The functionality of the ACT-R-based cognitive social simulation capability is presented and a number of areas of future development work are outlined. The paper also describes the motivation for adopting cognitive architectures in the context of social simulation experiments and presents a number of research areas where cognitive social simulation may be useful in developing a better understanding of the dynamics of team cognition. These include the use of cognitive social simulation to study the role of cognitive processes in determining aspects of communicative behavior, as well as the impact of communicative behavior on the shaping of task-relevant cognitive processes (e.g., the social shaping of individual and collective memory as a result of communicative exchanges). We suggest that the ability to perform cognitive social simulation experiments in these areas will help to elucidate some of the complex interactions that exist between cognitive, social, technological and informational factors in the context of team-based problem-solving activities.

  20. The major histocompatibility complex: a model for understanding graft-versus-host disease. (United States)

    Petersdorf, Effie W


    Acute graft-versus-host disease (GVHD) afflicts as much as 80% of all patients who receive an unrelated donor hematopoietic cell transplant (HCT) for the treatment of blood disorders, even with optimal donor HLA matching and use of prophylactic immunosuppressive agents. Of patients who develop acute GVHD, many are at risk for chronic GVHD and bear the burden of considerable morbidity and lowered quality of life years after transplantation. The immunogenetic basis of GVHD has been the subject of intensive investigation, with the classic HLA genetic loci being the best-characterized determinants. Recent information on the major histocompatibility complex (MHC) region of chromosome 6 as an important source of untyped genetic variation has shed light on novel GVHD determinants. These data open new paradigms for understanding the genetic basis of GVHD.

  1. Understanding the nuclear issues

    International Nuclear Information System (INIS)

    Mooradian, A.J.


    Nuclear power is presented as a necessary power source for the transition from fossil fuels to a no-growth society of the future. It is already economic and on-stream all over the world. Radiation is a very tractable hazard. New fuel cycles would provide extraordinary increases in our nuclear fuel reserves. (E.C.B.)

  2. A systematic approach to analyzing environmental issues involving complex systems (a web-based course

    Directory of Open Access Journals (Sweden)

    Marston Johnston


    Full Text Available The course “Conceptual Modeling for Decision Support” (Univ. Gothenburg, Sweden is a web-based course, given the first time in October 2015. This introduction and other supporting documents on the website intend to provide a background for independent work with the five tutorials that comprise the core of this course. The openly accessible website will allow study at any time, but can ideally be combined with the blended-learning course in “Environmental Geology” or with project work at various institutes in the relevant cooperation networks. The introduction below develops both the philosophical and the practical framework for modeling environmental systems. Differences in scale, time and the complexity are necessary to consider when evaluating the parameters within the system, but modeling is also an attempt to simplify in order to understand the net effects of the combined components. Multi-criteria evaluation allows predictive modelling by combining the typically qualitative and quantitative information from multidisciplinary sources.  The course structure and tutorials are briefly presented.

  3. Computational Cellular Dynamics Based on the Chemical Master Equation: A Challenge for Understanding Complexity (United States)

    Liang, Jie; Qian, Hong


    Modern molecular biology has always been a great source of inspiration for computational science. Half a century ago, the challenge from understanding macromolecular dynamics has led the way for computations to be part of the tool set to study molecular biology. Twenty-five years ago, the demand from genome science has inspired an entire generation of computer scientists with an interest in discrete mathematics to join the field that is now called bioinformatics. In this paper, we shall lay out a new mathematical theory for dynamics of biochemical reaction systems in a small volume (i.e., mesoscopic) in terms of a stochastic, discrete-state continuous-time formulation, called the chemical master equation (CME). Similar to the wavefunction in quantum mechanics, the dynamically changing probability landscape associated with the state space provides a fundamental characterization of the biochemical reaction system. The stochastic trajectories of the dynamics are best known through the simulations using the Gillespie algorithm. In contrast to the Metropolis algorithm, this Monte Carlo sampling technique does not follow a process with detailed balance. We shall show several examples how CMEs are used to model cellular biochemical systems. We shall also illustrate the computational challenges involved: multiscale phenomena, the interplay between stochasticity and nonlinearity, and how macroscopic determinism arises from mesoscopic dynamics. We point out recent advances in computing solutions to the CME, including exact solution of the steady state landscape and stochastic differential equations that offer alternatives to the Gilespie algorithm. We argue that the CME is an ideal system from which one can learn to understandcomplex behavior” and complexity theory, and from which important biological insight can be gained. PMID:24999297

  4. Venom Resistance as a Model for Understanding the Molecular Basis of Complex Coevolutionary Adaptations. (United States)

    Holding, Matthew L; Drabeck, Danielle H; Jansa, Sharon A; Gibbs, H Lisle


    SynopsisVenom and venom resistance are molecular phenotypes widely considered to have diversified through coevolution between predators and prey. However, while evolutionary and functional studies on venom have been extensive, little is known about the molecular basis, variation, and complexity of venom resistance. We review known mechanisms of venom resistance and relate these mechanisms to their predicted impact on coevolutionary dynamics with venomous enemies. We then describe two conceptual approaches which can be used to examine venom/resistance systems. At the intraspecific level, tests of local adaptation in venom and resistance phenotypes can identify the functional mechanisms governing the outcomes of coevolution. At deeper evolutionary timescales, the combination of phylogenetically informed analyses of protein evolution coupled with studies of protein function promise to elucidate the mode and tempo of evolutionary change on potentially coevolving genes. We highlight case studies that use each approach to extend our knowledge of these systems as well as address larger questions about coevolutionary dynamics. We argue that resistance and venom are phenotypic traits which hold exceptional promise for investigating the mechanisms, dynamics, and outcomes of coevolution at the molecular level. Furthermore, extending the understanding of single gene-for-gene interactions to the whole resistance and venom phenotypes may provide a model system for examining the molecular and evolutionary dynamics of complex multi-gene interactions. © The Author 2016. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email:

  5. The Nevada Rural Ozone Initiative (NVROI): Insights to understanding air pollution in complex terrain. (United States)

    Gustin, Mae Sexauer; Fine, Rebekka; Miller, Matthieu; Jaffe, Dan; Burley, Joel


    The Nevada Rural Ozone Initiative (NVROI) was established to better understand O3 concentrations in the Western United States (US). The major working hypothesis for development of the sampling network was that the sources of O3 to Nevada are regional and global. Within the framework of this overarching hypothesis, we specifically address two conceptual meteorological hypotheses: (1) The high elevation, complex terrain, and deep convective mixing that characterize Nevada, make this state ideally located to intercept polluted parcels of air transported into the US from the free troposphere; and (2) site specific terrain features will influence O3 concentrations observed at surface sites. Here, the impact of complex terrain and site location on observations are discussed. Data collected in Nevada at 6 sites (1385 to 2082 m above sea level (asl)) are compared with that collected at high elevation sites in Yosemite National Park and the White Mountains, California. Average daily maximum 1-hour concentrations of O3 during the first year of the NVROI ranged from 58 to 69 ppbv (spring), 53 to 62 ppbv (summer), 44 to 49 ppbv (fall), and 37 to 45 ppbv (winter). These were similar to those measured at 3 sites in Yosemite National Park (2022 to 3031 m asl), and at 4 sites in the White Mountains (1237 to 4342 m asl) (58 to 67 ppbv (summer) and 47 to 58 ppbv (fall)). Results show, that in complex terrain, collection of data should occur at high and low elevation sites to capture surface impacts, and site location with respect to topography should be considered. Additionally, concentrations measured are above the threshold reported for causing a reduction in growth and visible injury for plants (40 ppbv), and sustained exposure at high elevation locations in the Western USA may be detrimental for ecosystems. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Understanding Student Cognition about Complex Earth System Processes Related to Climate Change (United States)

    McNeal, K. S.; Libarkin, J.; Ledley, T. S.; Dutta, S.; Templeton, M. C.; Geroux, J.; Blakeney, G. A.


    The Earth's climate system includes complex behavior and interconnections with other Earth spheres that present challenges to student learning. To better understand these unique challenges, we have conducted experiments with high-school and introductory level college students to determine how information pertaining to the connections between the Earth's atmospheric system and the other Earth spheres (e.g., hydrosphere and cryosphere) are processed. Specifically, we include psychomotor tests (e.g., eye-tracking) and open-ended questionnaires in this research study, where participants were provided scientific images of the Earth (e.g., global precipitation and ocean and atmospheric currents), eye-tracked, and asked to provide causal or relational explanations about the viewed images. In addition, the students engaged in on-line modules ( focused on Earth system science as training activities to address potential cognitive barriers. The developed modules included interactive media, hands-on lessons, links to outside resources, and formative assessment questions to promote a supportive and data-rich learning environment. Student eye movements were tracked during engagement with the materials to determine the role of perception and attention on understanding. Students also completed a conceptual questionnaire pre-post to determine if these on-line curriculum materials assisted in their development of connections between Earth's atmospheric system and the other Earth systems. The pre-post results of students' thinking about climate change concepts, as well as eye-tracking results, will be presented.

  7. Understanding the Complexities of Food Safety Using a "One Health" Approach. (United States)

    Kniel, Kalmia E; Kumar, Deepak; Thakur, Siddhartha


    The philosophy of One Health is growing in concept and clarity. The interdependence of human, animal, and environmental health is the basis for the concept of One Health. One Health is a comprehensive approach to ensure the health of people, animals, and the environment through collaborative efforts. Preharvest food safety issues align with the grand concept of One Health. Imagine any food production system, and immediately, parallel images from One Health emerge: for example, transmission of zoonotic diseases, antibiotic residues, or resistance genes in the environment; environmental and animal host reservoirs of disease; challenges with rearing animals and growing fresh produce on the same farm; application and transport of manure or diseased animals. During a recent celebration of #OneHealthDay, information was shared around the globe concerning scientists dedicated to One Health research systems. An ever-growing trade and global commerce system mixed with our incessant desire for food products during the whole year makes it all the more important to take a global view through the One Health lens to solve these growing challenges. The recent explosion of Zika virus around the globe renewed the need for assessing transmissible diseases through the eyes of One Health. It is not good enough to know how a disease affects the human population without a thorough understanding of the environment and vector reservoirs. If 60 to 75% of infectious diseases affecting humans are of animal origin, the need for better One Health research strategies and overdue solutions is imperative.

  8. High School Students' Understanding of Change over Time and System Complexity: A Focus on the Cryosphere (United States)

    McNeal, K. S.; Libarkin, J.; Ledley, T. S.; Guthrie, C.


    Most students have difficulty articulating processes that are key for Earth’s changes and may have limited ability to understand Earth system science and think across spatial and temporal dimensions. The cryosphere, a complex and dynamic Earth system that exhibits change over time (e.g., seasonal, yearly, decadal, and millennial), can be difficult for students to reason about. The presented research assesses the effectiveness of the project developed on-line modules on high school students’ cryosphere content knowledge and skill development, including their: (1) conceptual understanding of ice, thermodynamics, climate, changes in ice cover over time, Earth system interactions, and complexity, and (2) use and interpretation of data and graphs about the cryosphere. Pre- and post- student assessments, classroom observations, and teacher interviews were collected from four high school classrooms in Texas to determine the effectiveness of the Earthlabs cryosphere modules in reaching the specified learning goals. Preliminary analysis of pre-and post-test data revealed a number of interesting changes where students displayed an increase in their awareness of the cryosphere, increase in confidence about cryosphere knowledge, and an increase in their ability to read and interpret graphs. Furthermore, classroom observations made for 25 minutes during a class period illustrated that for over 84% of the class period the students were engaged with the Earthlabs materials and spent the majority (>50%) of their time either discussing (31%) or working on the on-line Earthlabs cryosphere materials (29%). Finally, forty-five minute individual telephone interviews conducted with the four implementing cryosphere teachers revealed that teachers overwhelmingly reflected that the materials supported students’ ability to learn about the (i) nature and importance of the cryosphere, (ii) manipulation, analysis, interpretation of data, (iii) physical changes over multiple time scales

  9. Ethical and legal issues arising from complex genetic disorders. DOE final report

    Energy Technology Data Exchange (ETDEWEB)

    Andrews, Lori


    The project analyzed the challenges raised by complex genetic disorders in genetic counselling, for clinical practice, for public health, for quality assurance, and for protection against discrimination. The research found that, in some settings, solutions created in the context of single gene disorders are more difficult to apply to complex disorders. In other settings, the single gene solutions actually backfired and created additional problems when applied to complex genetic disorders. The literature of five common, complex genetic disorders--Alzheimer's, asthma, coronary heart disease, diabetes, and psychiatric illnesses--was evaluated in depth.

  10. Toward a better understanding of the complex geochemical processes governing subsurface contaminant transport

    International Nuclear Information System (INIS)

    Puls, R.W.


    Identification and understanding of the geochemical processes, including ion exchange, precipitation, organic partitioning, chemisorption, aqueous complexation, and colloidal stability and transport, controlling subsurface contamination is essential for making accurate predictions of the fate and transport of these constituents. Current approaches to quantify the effect of these processes primarily involve laboratory techniques, including the use of closed static systems (batch experiments) where small amounts of aquifer solids or minerals are contacted with an aqueous phase containing the components of interest for relatively short durations; and dynamic systems (column experiments) where a larger segment of the aquifer is investigated by analyzing the breakthrough profiles of reactive and non-reactive species. Both approaches are constrained by differences in scale, alteration of media during sample collection and use, and spatial variability. More field reactivity studies are needed to complement established laboratory approaches for the determination of retardation factors and scaling factors, corroboration of batch and column results, and validation of sampling techniques. These studies also serve to accentuate areas of geochemical process research where data deficiencies exist, such as the kinetics of adsorption-desorption, metal-organic-mineral interactions, and colloidal mobility. The advantages and disadvantages of the above approaches are discussed in the context of achieving a more completely integrated approach to geochemical transport experiments, with supportive data presented from selected studies. (Author) (16 refs., 4 figs., 2 tabs.)

  11. Understanding Epistatic Interactions between Genes Targeted by Non-coding Regulatory Elements in Complex Diseases

    Directory of Open Access Journals (Sweden)

    Min Kyung Sung


    Full Text Available Genome-wide association studies have proven the highly polygenic architecture of complex diseases or traits; therefore, single-locus-based methods are usually unable to detect all involved loci, especially when individual loci exert small effects. Moreover, the majority of associated single-nucleotide polymorphisms resides in non-coding regions, making it difficult to understand their phenotypic contribution. In this work, we studied epistatic interactions associated with three common diseases using Korea Association Resource (KARE data: type 2 diabetes mellitus (DM, hypertension (HT, and coronary artery disease (CAD. We showed that epistatic single-nucleotide polymorphisms (SNPs were enriched in enhancers, as well as in DNase I footprints (the Encyclopedia of DNA Elements [ENCODE] Project Consortium 2012, which suggested that the disruption of the regulatory regions where transcription factors bind may be involved in the disease mechanism. Accordingly, to identify the genes affected by the SNPs, we employed whole-genome multiple-cell-type enhancer data which discovered using DNase I profiles and Cap Analysis Gene Expression (CAGE. Assigned genes were significantly enriched in known disease associated gene sets, which were explored based on the literature, suggesting that this approach is useful for detecting relevant affected genes. In our knowledge-based epistatic network, the three diseases share many associated genes and are also closely related with each other through many epistatic interactions. These findings elucidate the genetic basis of the close relationship between DM, HT, and CAD.

  12. Complexities in Understanding Attentional Functioning among Children with Fetal Alcohol Spectrum Disorder

    Directory of Open Access Journals (Sweden)

    Kimberly eLane


    Full Text Available Parental reports of attention problems and clinical symptomatology of ADHD among children with fetal alcohol syndrome disorder (FASD were assessed in relation to performance on standardized subtests of attantional control/shifting and selective attention from the Test of Everyday Attention for Children (TEA-Ch; Manly et al., 1998. The participants included 14 children with FASD with a mean CA of 11.7 years and a mean MA of 9.7 years, and 14 typically developing (TD children with no reported history of prenatal exposure to alcohol or attention problems with a mean CA of 8.4 years and a mean MA of 9.6 years. The children with FASD were rated by their caregivers as having clinically significant attention difficulties for their developmental age. The reported symptomatology for the majority of the children with FASD were consistent with a diagnosis of ADHD, combined type, and only one child had a score within the average range. These reports are consistent with the finding here that the children with FASD demonstrated difficulties on the Creature Counting subtest of attentional control/shifting, but inconsistent with the finding that they outperformed the TD children on the Map Mission subtest of selective attention. These findings are considered within the context of the complexity in understanding attentional functioning among children with FASD and discrepancies across sources of information and components of attention.

  13. Understanding Immune Resistance to Infectious Bronchitis Using Major Histocompatibility Complex Chicken Lines. (United States)

    da Silva, A P; Hauck, R; Zhou, H; Gallardo, R A


    Genetic resistance or susceptibility to infectious diseases has been largely associated with the avian major histocompatibility complex (MHC) genes. Our goal was to determine resistance and susceptibility of MHC B haplotype in congenic and inbred chicken lines in order to establish a resistant-susceptible model. Eight congenic lines (253/B18, 254/B15, 330/B21, 312/B24, 331/B2, 335/B19, 336/B21, and 342/BO), two inbred lines (003/B17 and 077/B19), and three commercial lines (white leghorn, brown layers, and broilers) were used in two experiments. We analyzed and compared immunologic responses and the effect of challenge by measuring viral load, IgG and IgA humoral responses, histopathology and histomorphometry, clinical signs, and immune cell populations in the different MHC B haplotype lines. We found that respiratory signs, tracheal deciliation and inflammation, airsacculitis, viral shedding in tears, and local humoral responses were good parameters to determine resistance or susceptibility. Based on these results, we identified 331/B2 as the most resistant and 335/B19 as the most susceptible congenic chicken lines. These two lines will be used as an animal model in subsequent experiments to understand the mechanisms by which the immune system in chickens generates resistance to infectious bronchitis virus.

  14. Measurement issues associated with quantitative molecular biology analysis of complex food matrices for the detection of food fraud. (United States)

    Burns, Malcolm; Wiseman, Gordon; Knight, Angus; Bramley, Peter; Foster, Lucy; Rollinson, Sophie; Damant, Andrew; Primrose, Sandy


    Following a report on a significant amount of horse DNA being detected in a beef burger product on sale to the public at a UK supermarket in early 2013, the Elliott report was published in 2014 and contained a list of recommendations for helping ensure food integrity. One of the recommendations included improving laboratory testing capacity and capability to ensure a harmonised approach for testing for food authenticity. Molecular biologists have developed exquisitely sensitive methods based on the polymerase chain reaction (PCR) or mass spectrometry for detecting the presence of particular nucleic acid or peptide/protein sequences. These methods have been shown to be specific and sensitive in terms of lower limits of applicability, but they are largely qualitative in nature. Historically, the conversion of these qualitative techniques into reliable quantitative methods has been beset with problems even when used on relatively simple sample matrices. When the methods are applied to complex sample matrices, as found in many foods, the problems are magnified resulting in a high measurement uncertainty associated with the result which may mean that the assay is not fit for purpose. However, recent advances in the technology and the understanding of molecular biology approaches have further given rise to the re-assessment of these methods for their quantitative potential. This review focuses on important issues for consideration when validating a molecular biology assay and the various factors that can impact on the measurement uncertainty of a result associated with molecular biology approaches used in detection of food fraud, with a particular focus on quantitative PCR-based and proteomics assays.

  15. Issues of complexity in reading: Putting Occam's razor aside for now ...

    African Journals Online (AJOL)

    It is argued that, although reading and language are inextricably bound, reading is a highly complex system in its own right and, as such, approaches to reading should take account of this complexity and build it into their explanations of how reading works, how it develops and how it is practised. The foundations of a ...

  16. Collaborative Research. Damage and Burst Dynamics in Failure of Complex Geomaterials. A Statistical Physics Approach to Understanding the Complex Emergent Dynamics in Near Mean-Field Geological Materials

    Energy Technology Data Exchange (ETDEWEB)

    Rundle, John B. [Univ. of California, Davis, CA (United States); Klein, William [Boston Univ., MA (United States)


    We have carried out research to determine the dynamics of failure in complex geomaterials, specifically focusing on the role of defects, damage and asperities in the catastrophic failure processes (now popularly termed “Black Swan events”). We have examined fracture branching and flow processes using models for invasion percolation, focusing particularly on the dynamics of bursts in the branching process. We have achieved a fundamental understanding of the dynamics of nucleation in complex geomaterials, specifically in the presence of inhomogeneous structures.

  17. Exploring the application of an evolutionary educational complex systems framework to teaching and learning about issues in the science and technology classroom (United States)

    Yoon, Susan Anne

    Understanding the world through a complex systems lens has recently garnered a great deal of interest in many knowledge disciplines. In the educational arena, interactional studies, through their focus on understanding patterns of system behaviour including the dynamical processes and trajectories of learning, lend support for investigating how a complex systems approach can inform educational research. This study uses previously existing literature and tools for complex systems applications and seeks to extend this research base by exploring learning outcomes of a complex systems framework when applied to curriculum and instruction. It is argued that by applying the evolutionary dynamics of variation, interaction and selection, complexity may be harnessed to achieve growth in both the social and cognitive systems of the classroom. Furthermore, if the goal of education, i.e., the social system under investigation, is to teach for understanding, conceptual knowledge of the kind described in Popper's (1972; 1976) World 3, needs to evolve. Both the study of memetic processes and knowledge building pioneered by Bereiter (cf. Bereiter, 2002) draw on the World 3 notion of ideas existing as conceptual artifacts that can be investigated as products outside of the individual mind providing an educational lens from which to proceed. The curricular topic addressed is the development of an ethical understanding of the scientific and technological issues of genetic engineering. 11 grade 8 students are studied as they proceed through 40 hours of curricular instruction based on the complex systems evolutionary framework. Results demonstrate growth in both complex systems thinking and content knowledge of the topic of genetic engineering. Several memetic processes are hypothesized to have influenced how and why ideas change. Categorized by factors influencing either reflective or non-reflective selection, these processes appear to have exerted differential effects on students

  18. The complex clinical issues involved in an athlete's decision to retire from collision sport due to multiple concussions: a case study of a professional athlete

    Directory of Open Access Journals (Sweden)

    Andrew eGardner


    Full Text Available The issue of retirement from athletic participation due to repetitive concussive injuries remains controversial. The complexity of providing recommendations to elite athletes is highlighted by the prospect that offering inappropriate advice may foreseeably lead to engagement in a medico-legal challenge. Currently no evidenced-based, scientifically validated guidelines for forming the basis of such a decision exist. The current paper discusses the complexities of this challenge in addition to presenting a case study of a professional athlete. A number of central issues to consider when discussing athlete retirement revolve around the player’s medical and concussion histories, the current clinical profile, the athlete’s long-term life goals and understanding of the potential long-terms risks. Ensuring that thorough investigations of all possible differential diagnosis, that may explain the presenting symptoms, are conducted is also essential. Discussion pertaining to recommendations for guiding the clinical approach to the retirement issue for athletes with a history of multiple concussions is presented.

  19. The dichotomy between disease phenotype databases and the implications for understanding complex diseases involving the major histocompatibility complex. (United States)

    Clark, P M; Kunkel, M; Monos, D S


    Many genes related to innate and adaptive immunity reside within the major histocompatibility complex (MHC) and have been associated with a multitude of complex, immune-related disorders. Despite years of genetic study, this region has seen few causative determinants discovered for immune-mediated diseases. Reported associations have been curated in various databases including the Genetic Association Database, NCBI database of clinically relevant variants (ClinVar) and the Human Gene Mutation Database and together capture genetic associations and annotated pathogenic loci within the MHC and across the genome for a variety of complex, immune-mediated diseases. A review of these three distinct databases reveals disparate annotations between associated genes and pathogenic loci, alluding to the polygenic, multifactorial nature of immune-mediated diseases and the pleiotropic character of genes within the MHC. The technical limitations and inherent biases imposed by current approaches and technologies in studying the MHC create a strong case for the need to perform targeted deep sequencing of the MHC and other immunologically relevant loci in order to fully elucidate and study the causative elements of complex immune-mediated diseases. © 2015 The Authors. International Journal of Immunogenetics Published by John Wiley & Sons Ltd.

  20. Understanding Ethical Issues of Research Participation from the Perspective of Participating Children and Adolescents: A Systematic Review (United States)

    Broome, Marion E.


    Background The past twenty years have seen distinct shifts in the way the participation of children and adolescents in research is viewed. This has been emphasized by the growing pediatric research enterprise. Additional information on children’s and adolescents’ experiences during research participation is needed to better inform researchers on the ethical conduct of research with this vulnerable population. Aims The objective of this analysis was to examine ethical issues in research with children and adolescents from their perspective as participants, including: assent, parental consent, risk perception, impact of research participation, and incentives. Methods This systematic review was conducted per the Long et al. framework by means of an iterative searching process. Using the key words ‘research ethics’ and ‘child or pediatric or adolescent’, PubMed, CINAHL, and EBSCOhost databases were searched to identify articles. Limitations placed on the original searches were: English language, year of publication between 2003–2014, humans, abstract available, and age birth–18 years. Findings Twenty-three empiric studies were identified and formed the sample. Included studies represented a diverse range of areas of research, methods, settings, sample demographics, authors, and journals. Discussion Even young children demonstrated the ability to understand essential elements of research, although there is variability in children’s level of understanding. Trust was a significant contributing factor to children’s and adolescents’ participation in research, and also shaped their assessments of risk. Research participation was mainly beneficial for children and adolescents. Incentives were mainly viewed positively, although concerns of possible undue influence were expressed. Linking Evidence to Action This systematic review highlights the importance of including the perspectives of children and adolescents and provides researchers and nurse clinicians

  1. Framing participation with multicriterion evaluations to support the management of complex environmental issues

    NARCIS (Netherlands)

    Soma, K.


    A repeated statement observed in the literature is that stakeholder participation can contribute to improve complex environmental management decisions. However, transparent and legitimate decision-making processes cannot be ensured without suitable involvement strategies and information treatments

  2. The Value of a Comparative Approach to Understand the Complex Interplay between Microbiota and Host Immunity. (United States)

    Morella, Norma M; Koskella, Britt


    The eukaryote immune system evolved and continues to evolve within a microbial world, and as such is critically shaped by-and in some cases even reliant upon-the presence of host-associated microbial species. There are clear examples of adaptations that allow the host to simultaneously tolerate and/or promote growth of symbiotic microbiota while protecting itself against pathogens, but the relationship between immunity and the microbiome reaches far beyond simple recognition and includes complex cross talk between host and microbe as well as direct microbiome-mediated protection against pathogens. Here, we present a broad but brief overview of how the microbiome is controlled by and interacts with diverse immune systems, with the goal of identifying questions that can be better addressed by taking a comparative approach across plants and animals and different types of immunity. As two key examples of such an approach, we focus on data examining the importance of early exposure on microbiome tolerance and immune system development and function, and the importance of transmission among hosts in shaping the potential coevolution between, and long-term stability of, host-microbiome associations. Then, by comparing existing evidence across short-lived plants, mouse model systems and humans, and insects, we highlight areas of microbiome research that are strong in some systems and absent in others with the hope of guiding future research that will allow for broad-scale comparisons moving forward. We argue that such an approach will not only help with identification of generalities in host-microbiome-immune interactions but also improve our understanding of the role of the microbiome in host health.

  3. Raman analysis of DLC coated engine components with complex shape: Understanding wear mechanisms

    International Nuclear Information System (INIS)

    Jaoul, C.; Jarry, O.; Tristant, P.; Merle-Mejean, T.; Colas, M.; Dublanche-Tixier, C.; Jacquet, J.-M.


    Hydrogenated amorphous carbon (a-C:H) films were deposited on flat samples and engine components using an industrial scale reactor. Characterization of the coating allowed validating its application on engine parts due to high hardness (32 GPa) and high level of adhesion achieved using sublayers. The original approach of this work concerned the use of Raman analysis not only on flat samples after tribometer tests but also directly on coated engine parts with complex shape (like cam/follower system), in order to understand wear mechanisms occurring in motorsport engines. As wear could lead to a coating thickness decrease, a particular attention was paid on the Raman signal of the sublayers. Among the different values extracted from Raman spectrum to characterize structural organization, the value of G peak intensity appeared as a criterion of validity of analyses because it is directly linked to the remaining thickness of the a-C:H layer. For flat samples tested on ball-on-disc tribometer, structure of a-C:H film observed by Raman spectroscopy in the wear track remained stable in depth. Then, a-C:H coated engine components were studied before and after working in real conditions. Two different wear mechanisms were identified. The first one did not show any structural modification of the bulk a-C:H layer. In the second one, the high initial roughness of samples (R t = 1.15 μm) lead to coating delaminations after sliding. Massive graphitization which decreases drastically mechanical properties of the coatings was observed by Raman analyses on the contact area. The increase of the temperature on rough edges of the scratches could explain this graphitization.

  4. The Value of a Comparative Approach to Understand the Complex Interplay between Microbiota and Host Immunity

    Directory of Open Access Journals (Sweden)

    Norma M. Morella


    Full Text Available The eukaryote immune system evolved and continues to evolve within a microbial world, and as such is critically shaped by—and in some cases even reliant upon—the presence of host-associated microbial species. There are clear examples of adaptations that allow the host to simultaneously tolerate and/or promote growth of symbiotic microbiota while protecting itself against pathogens, but the relationship between immunity and the microbiome reaches far beyond simple recognition and includes complex cross talk between host and microbe as well as direct microbiome-mediated protection against pathogens. Here, we present a broad but brief overview of how the microbiome is controlled by and interacts with diverse immune systems, with the goal of identifying questions that can be better addressed by taking a comparative approach across plants and animals and different types of immunity. As two key examples of such an approach, we focus on data examining the importance of early exposure on microbiome tolerance and immune system development and function, and the importance of transmission among hosts in shaping the potential coevolution between, and long-term stability of, host–microbiome associations. Then, by comparing existing evidence across short-lived plants, mouse model systems and humans, and insects, we highlight areas of microbiome research that are strong in some systems and absent in others with the hope of guiding future research that will allow for broad-scale comparisons moving forward. We argue that such an approach will not only help with identification of generalities in host–microbiome–immune interactions but also improve our understanding of the role of the microbiome in host health.

  5. Applying Within-Family Differences Approaches to Enhance Understanding of the Complexity of Intergenerational Relations. (United States)

    Suitor, J Jill; Gilligan, Megan; Pillemer, Karl; Fingerman, Karen L; Kim, Kyungmin; Silverstein, Merril; Bengtson, Vern L


    The role of family relationships in the lives of older adults has received substantial attention in recent decades. Scholars have increasingly looked beyond simple models of family relations to approaches that recognize the complex and sometimes contradictory nature of these ties. One of the most exciting conceptual and methodological developments is the application of within-family differences approaches. In this paper, we focus on the ways in which such within-family approaches can extend the understanding of patterns and consequences of intergenerational ties in adulthood. Following a review of the conceptual underpinnings of within-family differences approaches, we provide empirical illustrations of these approaches from three projects conducted in the United States: the Family Exchanges Study (FES), the Longitudinal Study of Generations (LSOG), and the Within-Family Differences Study (WFDS). Analyses from the FES, LSOG, and WFDS reveal differences in the consequences of patterns of intergenerational relations found when using within-family compared to between-family approaches. In particular, these analyses demonstrate considerable variation within families that shapes patterns and consequences of parent-adult child ties that is masked when such variations are not taken into account. Within-family differences approaches have been shown to shed new light on intergenerational relations. Despite the value of within-family designs, their use may be limited by the higher investment of finances and time required to implement such studies. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail:

  6. “Designing Danger”: Complex Engineering by Violent Non-State Actors: Introduction to the Special Issue

    Directory of Open Access Journals (Sweden)

    Gary Ackerman


    Full Text Available This Special Issue of the Journal of Strategic Security (JSS presents the results of a series of case studies of prior efforts by VNSAs to engage in complex engineering tasks, in the hope of informing strategic assessments of the threat of VNSA exploitation of emerging technologies. One particular concern in international security lies at the nexus of violent non-state actors (VNSAs and sophisticated technologies. When it comes to the assessment of such threats, much of the analysis hinges upon being able to accurately judge the desire and capability of adversaries to successfully carry out complex engineering operations. Yet, the actual process of how and why VNSAs engage in these efforts and the determinants of their success or failure are understudied aspects, at least in terms of systematic comparison across actors, technologies and time periods. This special issue presents the results of a series of case studies of prior efforts by VNSAs to engage in complex engineering tasks, in the hope of informing strategic assessments of the threat of VNSA exploitation of emerging technologies. The introductory article defines a complex engineering effort, summarizes the existing literature on the topic and sets out the methodology and framing questions used in the case studies.

  7. Towards a comprehensive framework to govern the main sustainability issues of inland industrial complexes

    CSIR Research Space (South Africa)

    Mvuma, GG


    Full Text Available issues ? What sustainability includes, and for whom, and why sustainability is pursued, so that the goals for various stakeholders can be defined Slide 5 Define the most important criteria or indicators, that can be used to evaluate the extent... to which sustainable development is achieved, in a hierarchical tree Literature analysis and stakeholder engagement Research objectives #2 ? of this component of the larger WRC study ? Investigate the relationships between the endogenous variables...

  8. Locating and managing service-learning: A complex issue in higher ...

    African Journals Online (AJOL)

    Within the broad theoretical context provided by debates on the South African education reforms and the civic engagement agenda in higher education, this article focuses on service learning in higher education and portrays complex relationships between the service-learning office and different existing structures

  9. Expert views on scientific policy advice on complex environmental health issues

    NARCIS (Netherlands)

    Spruijt, P.


    Fact-based policies grounded in solid uncontested scientific evidence: this may sound as the ideal relation between science and policy. However, this ideal rarely holds for complex environmental health risks. When scientific knowledge is contested or incomplete, scientists can take different roles

  10. Methodological issues in analyzing human communication – the complexities of multimodality

    DEFF Research Database (Denmark)

    Høegh, Tina


    This chapter develops a multimodal method for transcribing speech, communication, and performance. The chapter discusses the methodological solutions to the complex translation of speech, language rhythm and gesture in time and space into the two-dimensional format of a piece of paper. The focus...

  11. Bike Helmets and Black Riders: Experiential Approaches to Helping Students Understand Natural Hazard Assessment and Mitigation Issues (United States)

    Stein, S. A.; Kley, J.; Hindle, D.; Friedrich, A. M.


    Defending society against natural hazards is a high-stakes game of chance against nature, involving tough decisions. How should a developing nation allocate its budget between building schools for towns without ones or making existing schools earthquake-resistant? Does it make more sense to build levees to protect against floods, or to prevent development in the areas at risk? Would more lives be saved by making hospitals earthquake-resistant, or using the funds for patient care? These topics are challenging because they are far from normal experience, in that they involve rare events and large sums. To help students in natural hazard classes conceptualize them, we pose tough and thought-provoking questions about complex issues involved and explore them together via lectures, videos, field trips, and in-class and homework questions. We discuss analogous examples from the students' experiences, drawing on a new book "Playing Against Nature, Integrating Science and Economics to Mitigate Natural Hazards in an Uncertain World". Asking whether they wear bicycle helmets and why or why not shows the cultural perception of risk. Individual students' responses vary, and the overall results vary dramatically between the US, UK, and Germany. Challenges in hazard assessment in an uncertain world are illustrated by asking German students whether they buy a ticket on public transportation - accepting a known cost - or "ride black" - not paying but risking a heavy fine if caught. We explore the challenge of balancing mitigation costs and benefits via the question "If you were a student in Los Angeles, how much more would you pay in rent each month to live in an earthquake-safe building?" Students learn that interdisciplinary thinking is needed, and that due to both uncertainties and sociocultural factors, no unique or right strategies exist for a particular community, much the less all communities. However, we can seek robust policies that give sensible results given

  12. Understanding Adult Learning in the Midst of Complex Social "Liquid Modernity" (United States)

    Nicolaides, Aliki; Marsick, Victoria J.


    This chapter describes the changing nature of adult education theory and practice in the face of complex, disruptive change and explores theories that are suited to tectonic shifts in a period of what we describe as "liquid modernity" in the midst of complex sociocultural-economic-political change in a global environment.

  13. Understanding IS Complexity and the Heterogeneity of Frames: The Illusion of Agreement

    NARCIS (Netherlands)

    Jochemsen, E.J.; Rezazade Mehrizi, M.H.; van den Hooff, B.J.; Plomp, M.G.A.


    Organizations are confronted with increasing levels of IS complexity. The socio-technical nature of IS implies that IS complexity stems from not only the structure of technology (e.g., how many elements and relations), but also from the subjective perceptions organizational actors have regarding

  14. Understanding complex governance relationships in food safety regulation : The RIT model as a theoretical lens

    NARCIS (Netherlands)

    Havinga, Tetty; Verbruggen, Paul

    In this contribution we discuss the added value of the RIT model for the analysis of complex governance relationships in the regulation of food safety. By exploring regimes of food safety involving the European Union and the Global Food Safety Initiative, we highlight the diverse and complex

  15. Understanding the Complexity of Temperature Dynamics in Xinjiang, China, from Multitemporal Scale and Spatial Perspectives

    Directory of Open Access Journals (Sweden)

    Jianhua Xu


    Full Text Available Based on the observed data from 51 meteorological stations during the period from 1958 to 2012 in Xinjiang, China, we investigated the complexity of temperature dynamics from the temporal and spatial perspectives by using a comprehensive approach including the correlation dimension (CD, classical statistics, and geostatistics. The main conclusions are as follows (1 The integer CD values indicate that the temperature dynamics are a complex and chaotic system, which is sensitive to the initial conditions. (2 The complexity of temperature dynamics decreases along with the increase of temporal scale. To describe the temperature dynamics, at least 3 independent variables are needed at daily scale, whereas at least 2 independent variables are needed at monthly, seasonal, and annual scales. (3 The spatial patterns of CD values at different temporal scales indicate that the complex temperature dynamics are derived from the complex landform.

  16. Understanding complex clinical reasoning in infectious diseases for improving clinical decision support design. (United States)

    Islam, Roosan; Weir, Charlene R; Jones, Makoto; Del Fiol, Guilherme; Samore, Matthew H


    Clinical experts' cognitive mechanisms for managing complexity have implications for the design of future innovative healthcare systems. The purpose of the study is to examine the constituents of decision complexity and explore the cognitive strategies clinicians use to control and adapt to their information environment. We used Cognitive Task Analysis (CTA) methods to interview 10 Infectious Disease (ID) experts at the University of Utah and Salt Lake City Veterans Administration Medical Center. Participants were asked to recall a complex, critical and vivid antibiotic-prescribing incident using the Critical Decision Method (CDM), a type of Cognitive Task Analysis (CTA). Using the four iterations of the Critical Decision Method, questions were posed to fully explore the incident, focusing in depth on the clinical components underlying the complexity. Probes were included to assess cognitive and decision strategies used by participants. The following three themes emerged as the constituents of decision complexity experienced by the Infectious Diseases experts: 1) the overall clinical picture does not match the pattern, 2) a lack of comprehension of the situation and 3) dealing with social and emotional pressures such as fear and anxiety. All these factors contribute to decision complexity. These factors almost always occurred together, creating unexpected events and uncertainty in clinical reasoning. Five themes emerged in the analyses of how experts deal with the complexity. Expert clinicians frequently used 1) watchful waiting instead of over- prescribing antibiotics, engaged in 2) theory of mind to project and simulate other practitioners' perspectives, reduced very complex cases into simple 3) heuristics, employed 4) anticipatory thinking to plan and re-plan events and consulted with peers to share knowledge, solicit opinions and 5) seek help on patient cases. The cognitive strategies to deal with decision complexity found in this study have important

  17. Introduction to the special issue on “Understanding and predicting change in the coastal ecosystems of the northern Gulf of Mexico” (United States)

    Brock, John C.; Barras, John A.; Williams, S. Jeffress


    The coastal region of the northern Gulf of Mexico owes its current landscape structure to an array of tectonic, erosional and depositional, climatic, geochemical, hydrological, ecological, and human processes that have resulted in some of the world's most complex, dynamic, productive, and threatened ecosystems. Catastrophic hurricane landfalls, ongoing subsidence and erosion exacerbated by sea-level rise, disintegration of barrier island chains, and high rates of wetland loss have called attention to the vulnerability of northern Gulf coast ecosystems, habitats, built infrastructure, and economy to natural and anthropogenic threats. The devastating hurricanes of 2005 (Katrina and Rita) motivated the U.S. Geological Survey Coastal and Marine Geology Program and partnering researchers to pursue studies aimed at understanding and predicting landscape change and the associated storm hazard vulnerability of northern Gulf coast region ecosystems and human communities. Attaining this science goal requires increased knowledge of landscape evolution on geologic, historical, and human time scales, and analysis of the implications of such changes in the natural and built components of the landscape for hurricane impact susceptibility. This Special Issue of the Journal of Coastal Research communicates northern Gulf of Mexico research results that (1) improve knowledge of prior climates and depositional environments, (2) assess broad regional ecosystem structure and change over Holocene to human time scales, (3) undertake process studies and change analyses of dynamic landscape components, and (4) integrate framework, climate, variable time and spatial scale mapping, monitoring, and discipline-specific process investigations within interdisciplinary studies.

  18. Remote Sensing of Complex Flows by Doppler Wind Lidar: Issues and Preliminary Recommendations

    Energy Technology Data Exchange (ETDEWEB)

    Clifton, Andrew [National Renewable Energy Lab. (NREL), Golden, CO (United States); Boquet, Matthieu [Leosphere, Orsay (France); Burin Des Roziers, Edward [UL International Gmbh, Freemont, CA (United States); Westerhellweg, Annette [UL International Gmbh, Freemont, CA (United States); Hofsass, Martin [Univ. of Stuttgart (Germany). Stuttgart Wind Energy; Klaas, Tobias [Fraunhofer Inst. for Wind Energy and Energy System Technology, Freiburg (Germany); Vogstad, Klaus [Meventus, Hamburg (Germany); Clive, Peter [Sgurr Energy, Glasgow (United Kingdom); Harris, Mike [ZephIR Limited, Kirkcudbrightshire (United Kingdom); Wylie, Scott [ZephIR Limited, Kirkcudbrightshire (United Kingdom); Osler, Evan [Renewable NRG Systems, Hinesburg, VT (United States); Banta, Bob [National Oceanic and Atmospheric Administration (NOAA), Boulder, CO (United States); Choukulkar, Aditya [National Oceanic and Atmospheric Administration (NOAA), Boulder, CO (United States); Lundquist, Julie [Univ. of Colorado, Boulder, CO (United States); Aitken, Matthew [Univ. of Colorado, Boulder, CO (United States)


    Remote sensing of winds using lidar has become popular and useful in the wind energy industry. Extensive experience has been gained with using lidar for applications including land-based and offshore resource assessment, plant operations, and turbine control. Prepared by members of International Energy Agency Task 32, this report describes the state of the art in the use of Doppler wind lidar for resource assessment in complex flows. The report will be used as input for future recommended practices on this topic.

  19. The Understanding of "Concept Study" in Teachers' Professional Learning: A Lived Experience of Complexity Inquiry (United States)

    Wang, Xiong


    This paper used narrative to present the author's understanding process of "concept study" in teachers' professional learning. The understanding process was advanced by several questions emerging from the preparation of doing "concept study". Thus, the several questions and their solutions became the threads of the narrative.…

  20. Complex contexts and dynamic drivers: Understanding four decades of forest loss and recovery in an East African protected area

    NARCIS (Netherlands)

    Sassen, M.; Sheil, D.; Giller, K.E.; Braak, ter C.J.F.


    Protected forests are sometimes encroached by surrounding communities. But patterns of cover change can vary even within one given setting – understanding these complexities can offer insights into the effective maintenance of forest cover. Using satellite image analyses together with historical

  1. New Age of 3D Geological Modelling or Complexity is not an Issue Anymore (United States)

    Mitrofanov, Aleksandr


    Geological model has a significant value in almost all types of researches related to regional mapping, geodynamics and especially to structural and resource geology of mineral deposits. Well-developed geological model must take into account all vital features of modelling object without over-simplification and also should adequately represent the interpretation of the geologist. In recent years with the gradual exhaustion deposits with relatively simple morphology geologists from all over the world are faced with the necessity of building the representative models for more and more structurally complex objects. Meanwhile, the amount of tools used for that has not significantly changed in the last two-three decades. The most widespread method of wireframe geological modelling now was developed in 1990s and is fully based on engineering design set of instruments (so-called CAD). Strings and polygons representing the section-based interpretation are being used as an intermediate step in the process of wireframes generation. Despite of significant time required for this type of modelling, it still can provide sufficient results for simple and medium-complexity geological objects. However, with the increasing complexity more and more vital features of the deposit are being sacrificed because of fundamental inability (or much greater time required for modelling) of CAD-based explicit techniques to develop the wireframes of the appropriate complexity. At the same time alternative technology which is not based on sectional approach and which uses the fundamentally different mathematical algorithms is being actively developed in the variety of other disciplines: medicine, advanced industrial design, game and cinema industry. In the recent years this implicit technology started to being developed for geological modelling purpose and nowadays it is represented by very powerful set of tools that has been integrated in almost all major commercial software packages. Implicit

  2. Sexual function and fertility issues in cases of exstrophy epispadias complex

    Directory of Open Access Journals (Sweden)

    M S Ansari


    Full Text Available In patients with EEC, the issues such as sexuality, sexual function and fertility gain more importance once theses patients advance from puberty to adulthood. The aim of this review is to critically examine the available evidence on these issues. A systemic literature search was performed in Medline over the last 25 years using the key words: Exstrophy, sexual function and pregnancy. Search results were limited to studies of patients with exstrophy published in English literature. A total of 1500 publications were found and subsequently screened by title and when appropriate by abstracts. Of these, 40 publications pertinent to the subject were included for the analysis. The publications were supplemented by an additional 15 publications obtained from their bibliographies. The studies were rated according to the guidelines published by the US department of health and human services. Heterosexuality is usually expressed in both the sexes and most of them have adequate sexual function. Urinary diversion in some series seems to result in better ejaculatory hence fertility outcome in male patients. Recent series have shown equally good results with primary reconstruction. Most of the female patients have normal fertility while male patients have significantly low fertility. Most of the male and female patients with EEC have adequate sexual function. Most of the female patients have normal fertility while most of the male patients have significantly low fertility.

  3. On understanding creative language : The late positive complex and novel metaphor comprehension

    NARCIS (Netherlands)

    Rataj, Karolina; Przekoracka-Krawczyk, Anna; van der Lubbe, Rob H.J.


    Novel metaphoric sentences have repeatedly evoked larger N400 amplitudes than literal sentences, while investigations of the late positive complex (LPC) have brought inconsistent results, with reports of both increased and reduced amplitudes. In two experiments, we examined novel metaphor

  4. Understanding the Fatigue Behavior of FML Structures and Materials under Complex Variable Amplitude Loading

    NARCIS (Netherlands)

    Alderdiesten, R.; Benedictus, R.; Khan, S.


    This paper presents various failure mechanisms in FMLs, highlights the presence or absence of interaction effects, and describes how the failure mechanisms can be described for predicting damage growth under arbitrary complex load spectra.

  5. Understanding and Mitigating the Charging Behavior of Next Generation Complex and Active Spacecraft (United States)

    National Aeronautics and Space Administration — Spacecraft that are fundamentally more complex and higher powered are necessary to expand our scientific missions and take commercial space endeavors to the next...

  6. Understanding environmental and climatic influences on regional differences and spatio-temporalscale issues of dengue fever transmission in Puerto Rico (United States)

    Serman, E. A.; Akanda, A. S. S.; Ginsberg, H. S.; Couret, J.


    Each year, there are an estimated 50-100 million cases of dengue fever worldwide, roughly 30 times the number of cases as 50 years ago, with some estimates even higher. Puerto Rico (PR) has experienced epidemic dengue activity since 1963, and the disease is currently endemic. Since 1990 there have been 4 large epidemics, the most recent in 2010 where there were nearly 27,000 cases reported, amounting to almost 1% of the island's total population. Because no vaccine is currently available, effective control is dependent on our ability to understand the complex relationship between environmental factors, mosquito vector ecology, and disease epidemiology. Dengue virus is transmitted primarily by Aedes aegypti mosquitoes, as humans are the preferred host for Ae. aegypti. The purpose of our analysis is to assess temporal and spatial patterns of dengue transmission in PR and relate this to both climatic and anthropogenic factors. Unlike past studies, which have used San Juan to represent the island as a whole, our research will investigate regional dynamics in dengue transmission, as preliminary results have shown significant differences in population density, disease incidence, and environmental and climatic variables. Data from the Passive Dengue Surveillance System of CDC, meteorological observations from NCDC, and remote sensing data from USGS and NASA will be used together to identify relationships between climate, urbanization, and dengue incidence for PR at various spatial and temporal scales. Preliminary climatic factors considered include precipitation, temperature, humidity, and soil moisture. Finally, we will assess measures of urbanization such as land cover, land use, population density, and infrastructure that can make regional differences in dengue incidence each year. Results from this study could help create early warning systems for dengue surveillance in Puerto Rico, and develop techniques that can be applied to other areas of the world.

  7. Research design issues for evaluating complex multicomponent interventions in neighborhoods and communities. (United States)

    Komro, Kelli A; Flay, Brian R; Biglan, Anthony; Wagenaar, Alexander C


    Major advances in population health will not occur unless we translate existing knowledge into effective multicomponent interventions, implement and maintain these in communities, and develop rigorous translational research and evaluation methods to ensure continual improvement and sustainability. We discuss challenges and offer approaches to evaluation that are key for translational research stages 3 to 5 to advance optimized adoption, implementation, and maintenance of effective and replicable multicomponent strategies. The major challenges we discuss concern (a) multiple contexts of evaluation/research, (b) complexity of packages of interventions, and (c) phases of evaluation/research questions. We suggest multiple alternative research designs that maintain rigor but accommodate these challenges and highlight the need for measurement systems. Longitudinal data collection and a standardized continuous measurement system are fundamental to the evaluation and refinement of complex multicomponent interventions. To be useful to T3-T5 translational research efforts in neighborhoods and communities, such a system would include assessments of the reach, implementation, effects on immediate outcomes, and effects of the comprehensive intervention package on more distal health outcomes.

  8. Aging and selective attention: an issue of complexity or multiple mechanisms? (United States)

    Brink, J M; McDowd, J M


    Previous studies have shown age-associated deficits in selective attention that vary as a function of task demands. The present study was conducted to dissociate the effect of task complexity on age-related performance differences from qualitative differences in cognitive demands. Twenty-four young and 24 older adults were administered two versions of the Stroop Test (Hartley, 1993). The Color-Block version required identifying the color of a box while ignoring the name of a color printed either above or below the box. The Color-Word version required naming the color of a word while ignoring the semantic meaning of the word (a color name). Each version of the task included a two- and four-color choice condition as a manipulation of task complexity. Old and young adults performed comparably on the Color-Block Task, but older adults were significantly impaired on both conditions of the Color-Word Task, particularly in the four-choice condition. Results suggest age-related differences in the distinct attentional processes demanded by each task are not attributable to general slowing.

  9. Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease. (United States)

    Borroto-Escuela, Dasiel O; Carlsson, Jens; Ambrogini, Patricia; Narváez, Manuel; Wydra, Karolina; Tarakanov, Alexander O; Li, Xiang; Millón, Carmelo; Ferraro, Luca; Cuppini, Riccardo; Tanganelli, Sergio; Liu, Fang; Filip, Malgorzata; Diaz-Cabiale, Zaida; Fuxe, Kjell


    The introduction of allosteric receptor-receptor interactions in G protein-coupled receptor (GPCR) heteroreceptor complexes of the central nervous system (CNS) gave a new dimension to brain integration and neuropsychopharmacology. The molecular basis of learning and memory was proposed to be based on the reorganization of the homo- and heteroreceptor complexes in the postjunctional membrane of synapses. Long-term memory may be created by the transformation of parts of the heteroreceptor complexes into unique transcription factors which can lead to the formation of specific adapter proteins. The observation of the GPCR heterodimer network (GPCR-HetNet) indicated that the allosteric receptor-receptor interactions dramatically increase GPCR diversity and biased recognition and signaling leading to enhanced specificity in signaling. Dysfunction of the GPCR heteroreceptor complexes can lead to brain disease. The findings of serotonin (5-HT) hetero and isoreceptor complexes in the brain over the last decade give new targets for drug development in major depression. Neuromodulation of neuronal networks in depression via 5-HT, galanin peptides and zinc involve a number of GPCR heteroreceptor complexes in the raphe-hippocampal system: GalR1-5-HT1A, GalR1-5-HT1A-GPR39, GalR1-GalR2, and putative GalR1-GalR2-5-HT1A heteroreceptor complexes. The 5-HT1A receptor protomer remains a receptor enhancing antidepressant actions through its participation in hetero- and homoreceptor complexes listed above in balance with each other. In depression, neuromodulation of neuronal networks in the raphe-hippocampal system and the cortical regions via 5-HT and fibroblast growth factor 2 involves either FGFR1-5-HT1A heteroreceptor complexes or the 5-HT isoreceptor complexes such as 5-HT1A-5-HT7 and 5-HT1A-5-HT2A. Neuromodulation of neuronal networks in cocaine use disorder via dopamine (DA) and adenosine signals involve A2AR-D2R and A2AR-D2R-Sigma1R heteroreceptor complexes in the dorsal and

  10. Understanding M-ligand bonding and mer-/fac-isomerism in tris(8-hydroxyquinolinate) metallic complexes. (United States)

    Lima, Carlos F R A C; Taveira, Ricardo J S; Costa, José C S; Fernandes, Ana M; Melo, André; Silva, Artur M S; Santos, Luís M N B F


    Tris(8-hydroxyquinolinate) metallic complexes, Mq3, are one of the most important classes of organic semiconductor materials. Herein, the nature of the chemical bond in Mq3 complexes and its implications on their molecular properties were investigated by a combined experimental and computational approach. Various Mq3 complexes, resulting from the alteration of the metal and substitution of the 8-hydroxyquinoline ligand in different positions, were prepared. The mer-/fac-isomerism in Mq3 was explored by FTIR and NMR spectroscopy, evidencing that, irrespective of the substituent, mer- and fac-are the most stable molecular configurations of Al(iii) and In(iii) complexes, respectively. The relative M-ligand bond dissociation energies were evaluated experimentally by electrospray ionization tandem mass spectrometry (ESI-MS-MS), showing a non-monotonous variation along the group (Al > In > Ga). The results reveal a strong covalent character in M-ligand bonding, which allows for through-ligand electron delocalization, and explain the preferred molecular structures of Mq3 complexes as resulting from the interplay between bonding and steric factors. The mer-isomer reduces intraligand repulsions, being preferred for smaller metals, while the fac-isomer is favoured for larger metals where stronger covalent M-ligand bonds can be formed due to more extensive through-ligand conjugation mediated by metal "d" orbitals.

  11. Further Understanding of Complex Information Processing in Verbal Adolescents and Adults with Autism Spectrum Disorders (United States)

    Williams, Diane L.; Minshew, Nancy J.; Goldstein, Gerald


    More than 20?years ago, Minshew and colleagues proposed the Complex Information Processing model of autism in which the impairment is characterized as a generalized deficit involving multiple modalities and cognitive domains that depend on distributed cortical systems responsible for higher order abilities. Subsequent behavioral work revealed a…

  12. Contemporary Leadership Theories. Enhancing the Understanding of the Complexity, Subjectivity and Dynamic of Leadership

    DEFF Research Database (Denmark)

    Winkler, Ingo

    . Leadership is understood as product of complex social relationships embedded in the logic and dynamic of the social system. The book discusses theoretical approaches from top leadership journals, but also addresses various alternatives that are suitable to challenge mainstream leadership research...

  13. Sedimentary Melanges and Fossil Mass-Transport Complexes: A Key for Better Understanding Submarine Mass Movements?

    NARCIS (Netherlands)

    Pini, Gian Andrea; Ogata, Kei; Camerlenghi, Angelo; Festa, Andrea; Lucente, Claudio Corrado; Codegone, Giulia


    Mélanges originated from sedimentary processes (sedimentary mélanges) and olistostromes are frequently present in mountain chains worldwide. They are excellent fossil examples of mass- Transport complexes (MTC), often cropping out in well-preserved and laterally continuous exposures. In this article

  14. Understanding the Complex Processes in Developing Student Teachers' Knowledge about Grammar (United States)

    Svalberg, Agneta M.-L.


    This article takes the view that grammar is driven by user choices and is therefore complex and dynamic. This has implications for the teaching of grammar in language teacher education and how teachers' cognitions about grammar, and hence their own grammar teaching, might change. In this small, interpretative study, the participants--students on…

  15. Language complexity during read-alouds and kindergartners' vocabulary and symbolic understanding

    NARCIS (Netherlands)

    Mascareño Lara, Mayra; Snow, Catherine E.; Deunk, Marjolein I.; Bosker, Roel J.


    We explored links between complexity of teacher-child verbal interaction and child language and literacy outcomes in fifteen whole-class read-aloud sessions in Chilean kindergarten classrooms serving children from low socioeconomic backgrounds. We coded teacher and child turns for function

  16. Using multi-criteria analysis of simulation models to understand complex biological systems (United States)

    Maureen C. Kennedy; E. David. Ford


    Scientists frequently use computer-simulation models to help solve complex biological problems. Typically, such models are highly integrated, they produce multiple outputs, and standard methods of model analysis are ill suited for evaluating them. We show how multi-criteria optimization with Pareto optimality allows for model outputs to be compared to multiple system...

  17. Generics Substitution, Bioequivalence Standards, and International Oversight: Complex Issues Facing the FDA. (United States)

    Bate, Roger; Mathur, Aparna; Lever, Harry M; Thakur, Dinesh; Graedon, Joe; Cooperman, Tod; Mason, Preston; Fox, Erin R


    The regulations for assessing the quality of generic drugs and their bioequivalence to innovator products are outdated and need to be substantially modernized. There are multiple reasons why these changes are needed, including: (i) the regulations remain largely unchanged since the passage of the Hatch-Waxman Act in 1984; (ii) medication therapies have become substantially more complex over the three decades since the passage of the Act; (iii) a switch from an innovator drug to a generic drug, or switching from one generic to another, is not a benign process - there is substantial clinical professional judgment involved and in some instances these decisions should be better informed; and (iv) pharmaceutical ingredients for finished products, whether innovator or generic, are from multiple sources of supply, adding variability in their production, and which may not be accounted for in specification tolerances. When these elements are viewed together, they clearly suggest that more transparency of responsible manufacturers in product labels and updated standards for bioequivalence are required. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Quantum mechanics of excitation transport in photosynthetic complexes: a key issues review. (United States)

    Levi, Federico; Mostarda, Stefano; Rao, Francesco; Mintert, Florian


    For a long time microscopic physical descriptions of biological processes have been based on quantum mechanical concepts and tools, and routinely employed by chemical physicists and quantum chemists. However, the last ten years have witnessed new developments on these studies from a different perspective, rooted in the framework of quantum information theory. The process that more, than others, has been subject of intense research is the transfer of excitation energy in photosynthetic light-harvesting complexes, a consequence of the unexpected experimental discovery of oscillating signals in such highly noisy systems. The fundamental interdisciplinary nature of this research makes it extremely fascinating, but can also constitute an obstacle to its advance. Here in this review our objective is to provide an essential summary of the progress made in the theoretical description of excitation energy dynamics in photosynthetic systems from a quantum mechanical perspective, with the goal of unifying the language employed by the different communities. This is initially realized through a stepwise presentation of the fundamental building blocks used to model excitation transfer, including protein dynamics and the theory of open quantum system. Afterwards, we shall review how these models have evolved as a consequence of experimental discoveries; this will lead us to present the numerical techniques that have been introduced to quantitatively describe photo-absorbed energy dynamics. Finally, we shall discuss which mechanisms have been proposed to explain the unusual coherent nature of excitation transport and what insights have been gathered so far on the potential functional role of such quantum features.


    Directory of Open Access Journals (Sweden)

    Виталий Николаевич Маковеев


    Full Text Available Transition of the Russian economy to an innovation type of development, selected by leaders of the country as a priority one, creates the need of solving number of problems. A key one is the need for large-scale renovation of the economy’s production basis, which can not be implemented without a modern machine building sector.Purpose. To analyze development of machine building complex in theVologda region against the all-Russian background, to identify common trends and challenges of the sector’s development.Methodology. Methods of system and structural analysis, comparison, differences and similarities analysis, deduction and induction were used. Official statistics, as well as the works of prominent scientists in this field, served as an information basis for the study.Results. The author conducted an analysis of basic production assets, growth rates, the financial situation, investments, levels of profitability, staffing and salary levels of employees of machine building sector of the Vologda Region and Russia. The main trends and problems of the sector development were identified. Measures that are able to change the situation were proposed.Practical implications. The research materials could be useful for regional authorities in forming industrial and innovation policy, as well as for all those interested in problems of machine building development.DOI:

  20. Understanding Alzheimer's (United States)

    ... Navigation Bar Home Current Issue Past Issues Understanding Alzheimer's Past Issues / Fall 2007 Table of Contents For ... and brain scans. No treatment so far stops Alzheimer's. However, for some in the disease's early and ...

  1. Techniques to better understand complex epikarst hydrogeology and contaminant transport in telogenetic karst settings (United States)

    The movement of autogenic recharge through the shallow epikarstic zone in soil-mantled karst aquifers is important in understanding recharge areas and rates, groundwater storage, and contaminant transport processes. The groundwater flow in agricultural karst areas, such as Kentucky’s Pennyroyal Plat...

  2. Complex Problem Solving in Radiologic Technology: Understanding the Roles of Experience, Reflective Judgment, and Workplace Culture (United States)

    Yates, Jennifer L.


    The purpose of this research study was to explore the process of learning and development of problem solving skills in radiologic technologists. The researcher sought to understand the nature of difficult problems encountered in clinical practice, to identify specific learning practices leading to the development of professional expertise, and to…

  3. Preschoolers' Implicit and Explicit False-Belief Understanding: Relations with Complex Syntactical Mastery (United States)

    Low, Jason


    Three studies were carried out to investigate sentential complements being the critical device that allows for false-belief understanding in 3- and 4-year-olds (N = 102). Participants across studies accurately gazed in anticipation of a character's mistaken belief in a predictive looking task despite erring on verbal responses for direct…

  4. Human Factors and Organizational Issues in 2015: The Increasing Complexity of the Healthcare Domain Calls for More Comprehensive Approaches (United States)


    Summary Objective To summarize significant research contributions on human factors and organizational issues in medical informatics published in 2015. Methods An extensive search using PubMed/Medline and Web of Science® was conducted to identify the scientific contributions published in 2015 that address human factors and organizational issues in medical informatics. The selection process comprised three steps: (i) 15 candidate best papers were first selected by the two section editors, (ii) external reviewers from internationally renowned research teams reviewed each candidate best paper, and (iii) the final selection of five best papers was conducted by the editorial board of the Yearbook. Results Noteworthy papers in 2015 emphasize the increasing complexity of the healthcare environment. They call for more comprehensive approaches and evaluation studies. All provide a real added-value in this direction. Conclusion There is no more need to promote the contribution of human factors and ergonomics (HFE) approaches to health IT-related risks and patient safety. However, there is still a need for research on HFE methods to adapt health information technology tools to the complexity of the healthcare domain. PMID:27830240

  5. [Reports on the impact of objects emitting electromagnetic fields on the environment: issues concerning their better understanding by non-specialists in telecommunication]. (United States)

    Bieńkowski, Paweł


    The paper presents issues concerning a better understanding of reports on the impact of objects emitting electromagnetic fields on the environment among non-specialists in telecommunication. A proposed universal model of the radiation pattern of antenna base stations to widen the information contained in environmental audits as well as a vocabulary of basic technical terms in colloquial language are discussed.

  6. Landscape community genomics: understanding eco-evolutionary processes in complex environments (United States)

    Hand, Brian K.; Lowe, Winsor H.; Kovach, Ryan P.; Muhlfeld, Clint C.; Luikart, Gordon


    Extrinsic factors influencing evolutionary processes are often categorically lumped into interactions that are environmentally (e.g., climate, landscape) or community-driven, with little consideration of the overlap or influence of one on the other. However, genomic variation is strongly influenced by complex and dynamic interactions between environmental and community effects. Failure to consider both effects on evolutionary dynamics simultaneously can lead to incomplete, spurious, or erroneous conclusions about the mechanisms driving genomic variation. We highlight the need for a landscape community genomics (LCG) framework to help to motivate and challenge scientists in diverse fields to consider a more holistic, interdisciplinary perspective on the genomic evolution of multi-species communities in complex environments.

  7. Eating disorder emergencies: understanding the medical complexities of the hospitalized eating disordered patient. (United States)

    Cartwright, Martina M


    Eating disorders are maladaptive eating behaviors that typically develop in adolescence and early adulthood. Psychiatric maladies and comorbid conditions, especially insulin-dependent diabetes mellitus, frequently co-exist with eating disorders. Serious medical complications affecting all organs and tissues can develop and result in numerous emergent hospitalizations. This article reviews the pathophysiologies of anorexia nervosa, bulimia nervosa, and orthorexia nervosa and discusses the complexities associated with the treatment of medical complications seen in these patients.

  8. Using mLearning and MOOCs to Understand Chaos, Emergence, and Complexity in Education (United States)

    deWaard, Inge; Abajian, Sean; Gallagher, Michael Sean; Hogue, Rebecca; Keskin, Nilgun; Koutropoulos, Apostolos; Rodriguez, Osvaldo C.


    In this paper, we look at how the massive open online course (MOOC) format developed by connectivist researchers and enthusiasts can help analyze the complexity, emergence, and chaos at work in the field of education today. We do this through the prism of a MobiMOOC, a six-week course focusing on mLearning that ran from April to May 2011. MobiMOOC…

  9. Systems-synthetic biology in understanding the complexities and simple devices in immunology. (United States)

    Soni, Bhavnita; Nimsarkar, Prajakta; Mol, Milsee; Saha, Bhaskar; Singh, Shailza


    Systems and synthetic biology in the coming era has the ability to manipulate, stimulate and engineer cells to counteract the pathogenic immune response. The inherent biological complexities associated with the creation of a device allow capitalizing the biotechnological resources either by simply administering a recombinant cytokine or just reprogramming the immune cells. The strategy outlined, adopted and discussed may mark the beginning with promising therapeutics based on the principles of synthetic immunology. Copyright © 2018 Elsevier Ltd. All rights reserved.

  10. Complex Systems Biology Approach To Understanding Coordination of JAK-STAT Signaling


    Soebiyanto, Radina P.; Sreenath, Sree N.; Qu, Cheng-Kui; Loparo, Kenneth A.; Bunting, Kevin D.


    In this work, we search for coordination as an organizing principle in a complex signaling system using a multilevel hierarchical paradigm. The objective is to explain the underlying mechanism of Interferon (IFNγ) induced JAK-STAT (specifically JAK1/JAK2-STAT1) pathway behavior. Starting with a mathematical model of the pathway from the literature, we modularize the system using biological knowledge via principles of biochemical cohesion, biological significance, and functionality. The modula...

  11. Some Key Issues in Creating Inquiry-Based Instructional Practices that Aim at the Understanding of Simple Electric Circuits (United States)

    Kock, Zeger-Jan; Taconis, Ruurd; Bolhuis, Sanneke; Gravemeijer, Koeno


    Many students in secondary schools consider the sciences difficult and unattractive. This applies to physics in particular, a subject in which students attempt to learn and understand numerous theoretical concepts, often without much success. A case in point is the understanding of the concepts current, voltage and resistance in simple electric…

  12. Some Key Issues in Creating Inquiry-Based Instructional Practices that Aim at the Understanding of Simple Electric Circuits

    NARCIS (Netherlands)

    Zeger-Jan Kock; Koeno Gravemeijer; Dr. S. Bolhuis; Ruurd Taconis


    Many students in secondary schools consider the sciences difficult and unattractive. This applies to physics in particular, a subject in which students attempt to learn and understand numerous theoretical concepts, often without much success. A case in point is the understanding of the concepts

  13. Douglas Hanahan: The daunting complexity of cancer: understanding the battlefield is a step towards winning the war

    CERN Multimedia

    CERN. Geneva


    The Inaugural Grace-CERN Lecture The daunting complexity of cancer: understanding the battlefield is a step towards winning the war  Douglas Hanahan, Ph.D. Director, Swiss Institute for Experimental Cancer Research (ISREC)  Professor of Molecular Oncology, School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL) Vice Director, Swiss Cancer Center Lausanne Synopsis (version francaise ci-dessous) Cancer is a disease with hundreds of variations, both in affected organs and in responses to different therapies.  Modern human cancer research is producing an avalanche of data about the distinctive genetic aberrations of its specific types, further accentuating the diversity and vast complexity of the disease. There is hope that elucidating its mechanisms will lead to more informed and more effective therapeutic strategies.  Understanding the enemy is paramount, and yet tumors arising in different organs can be so different as to de...

  14. Understanding ageing effects using complexity analysis of foot-ground clearance during walking. (United States)

    Karmakar, Chandan; Khandoker, Ahsan; Begg, Rezaul; Palaniswami, Marimuthu


    Ageing influences gait patterns which in turn can affect the balance control of human locomotion. Entropy-based regularity and complexity measures have been highly effective in analysing a broad range of physiological signals. Minimum toe clearance (MTC) is an event during the swing phase of the gait cycle and is highly sensitive to the spatial balance control properties of the locomotor system. The aim of this research was to investigate the regularity and complexity of the MTC time series due to healthy ageing and locomotors' disorders. MTC data from 30 healthy young (HY), 27 healthy elderly (HE) and 10 falls risk (FR) elderly subjects with balance problems were analysed. Continuous MTC data were collected and using the first 500 data points, MTC mean, standard deviation (SD) and entropy-based complexity analysis were performed using sample entropy (SampEn) for different window lengths (m) and filtering levels (r). The MTC SampEn values were lower in the FR group compared to the HY and HE groups for all m and r. The HY group had a greater mean SampEn value than both HE and FR reflecting higher complexity in their MTC series. The mean SampEn values of HY and FR groups were found significantly different for m = 2, 4, 5 and r = (0.1-0.9) × SD, (0.3-0.9) × SD and (0.3-0.9) × SD, respectively. They were also significant difference between HE and FR groups for m = 4-5 and r = (0.3-0.7) × SD, but no significant differences were seen between HY and HE groups for any m and r. A significant correlation of SampEn with SD of MTC was revealed for the HY and HE groups only, suggesting that locomotor disorders could significantly change the regularity or the complexity of the MTC series while healthy ageing does not. These results can be usefully applied to the early diagnosis of common gait pathologies.

  15. Using a Design Science Perspective to Understand a Complex Design-Based Research Process

    DEFF Research Database (Denmark)

    Bækgaard, Lars


    The purpose of the paper is to demonstrate how a design science perspective can be used to describe and understand a set of related design-based research processes. We describe and analyze a case study in a manner that is inspired by design science. The case study involves the design of modeling......-based research processes. And we argue that a design science perspective may be useful for both researchers and practitioners....... tools and the redesign of an information service in a library. We use a set of guidelines from a design science perspective to organize the description and analysis of the case study. By doing this we demonstrate the usefulness of design science as an analytical tool for understanding related design...

  16. Enacting understanding of inclusion in complex contexts: Classroom practices of South African teachers

    Directory of Open Access Journals (Sweden)

    Petra Engelbrecht


    Full Text Available While the practice of inclusive education has recently been widely embraced as an ideal model for education, the acceptance of inclusive education practices has not translated into reality in most mainstream classrooms. Despite the fact that education policies in South Africa stipulate that all learners should be provided with the opportunities to participate as far as possible in all classroom activities, the implementation of inclusive education is still hampered by a combination of a lack of resources and the attitudes and actions of the teachers in the classroom. The main purpose of this paper was to develop a deeper understanding of a group of South African teachers' personal understanding about barriers to learning and how their understanding relates to their consequent actions to implement inclusive education in their classrooms. A qualitative research approach placed within a cultural-historical and bio-ecological theoretical framework was used. The findings, in this paper, indicate that the way in which teachers understand a diversity of learning needs is based on the training that they initially received as teachers, which focused on a deficit, individualised approach to barriers to learning and development, as well as contextual challenges, and that both have direct and substantial effects on teachers' classroom practices. As a result, they engage in practices in their classrooms that are less inclusive, by creating dual learning opportunities that are not sufficiently made available for everyone, with the result that every learner is not able to participate fully as an accepted member of their peer group in all classroom activities.

  17. Emergent nested systems a theory of understanding and influencing complex systems as well as case studies in urban systems

    CERN Document Server

    Walloth, Christian


    This book presents a theory as well as methods to understand and to purposively influence complex systems. It suggests a theory of complex systems as nested systems, i. e. systems that enclose other systems and that are simultaneously enclosed by even other systems. According to the theory presented, each enclosing system emerges through time from the generative activities of the systems they enclose. Systems are nested and often emerge unplanned, and every system of high dynamics is enclosed by a system of slower dynamics. An understanding of systems with faster dynamics, which are always guided by systems of slower dynamics, opens up not only new ways to understanding systems, but also to effectively influence them. The aim and subject of this book is to lay out these thoughts and explain their relevance to the purposive development of complex systems, which are exemplified in case studies from an urban system. The interested reader, who is not required to be familiar with system-theoretical concepts or wit...

  18. Understanding the Narratives Explaining the Ukrainian Crisis: Identity Divisions and Complex Diversity in Ukraine

    Directory of Open Access Journals (Sweden)

    Smoor Lodewijk


    Full Text Available The central argument of this paper is that radical and opposing interpretations of the Ukrainian conflict in politics and media should be studied as offspring of broader narratives. These narratives can be better understood by examining the national identity of Ukraine. Since Ukrainian national identity shows a high degree of diversity, it offers a rich source of arguments for any party wanting to give an interpretation of the present Ukrainian crisis. Narratives explaining the crisis often ignore this complex diversity or deliberately use elements from it to construct the ‘desired’ narrative.

  19. Toward a Greater Understanding: Utilizing Book Discussions to Effectively Engage Students in the Exploration of Women and Leadership Issues (United States)

    Scott, Heather Inez Ricks


    This article examines the use of a book discussion as an instructional tool for developing leadership competency skills in female university students. A book discussion centered on Sheryl Sandberg's book "Lean In" was held as a means to conceptualize discourse regarding leadership issues in the arena of women and leadership in a…

  20. Understanding Domestic Violence Resource Utilization and Survivor Solutions Among Immigrant and Refugee Women. Introduction to the Special Issue (United States)

    Bhuyan, Rupaleem; Senturia, Kirsten


    The articles in this issue of the "Journal of Interpersonal Violence" were generated using community-based participatory action research to explore how different cultural communities interpret and respond to DV. This partnership began in 1999 and involved Public Health?Seattle and King County, several community-based agencies, and researchers at…

  1. Take a stand on understanding: electrophysiological evidence for stem access in German complex verbs. (United States)

    Smolka, Eva; Gondan, Matthias; Rösler, Frank


    The lexical representation of complex words in Indo-European languages is generally assumed to depend on semantic compositionality. This study investigated whether semantically compositional and noncompositional derivations are accessed via their constituent units or as whole words. In an overt visual priming experiment (300 ms stimulus onset asynchrony, SOA), event-related potentials (ERPs) were recorded for verbs (e.g., ziehen, "pull") that were preceded by purely semantically related verbs (e.g., zerren, "drag"), by morphologically related and semantically compositional verbs (e.g., zuziehen, "pull together"), by morphologically related and semantically noncompositional verbs (e.g., erziehen, "educate"), by orthographically similar verbs (e.g., zielen, "aim"), or by unrelated verbs (e.g., tarnen, "mask"). Compared to the unrelated condition, which evoked an N400 effect with the largest amplitude at centro-parietal recording sites, the N400 was reduced in all other conditions. The rank order of N400 amplitudes turned out as follows: morphologically related and semantically compositional ≈ morphologically related and semantically noncompositional morphologically related primes produced similar N400 modulations-irrespective of their semantic compositionality. The control conditions with orthographic similarity confirmed that these morphological effects were not the result of a simple form overlap between primes and targets. Our findings suggest that the lexical representation of German complex verbs refers to their base form, regardless of meaning compositionality. Theories of the lexical representation of German words need to incorporate this aspect of language processing in German.

  2. Understanding characteristics in multivariate traffic flow time series from complex network structure (United States)

    Yan, Ying; Zhang, Shen; Tang, Jinjun; Wang, Xiaofei


    Discovering dynamic characteristics in traffic flow is the significant step to design effective traffic managing and controlling strategy for relieving traffic congestion in urban cities. A new method based on complex network theory is proposed to study multivariate traffic flow time series. The data were collected from loop detectors on freeway during a year. In order to construct complex network from original traffic flow, a weighted Froenius norm is adopt to estimate similarity between multivariate time series, and Principal Component Analysis is implemented to determine the weights. We discuss how to select optimal critical threshold for networks at different hour in term of cumulative probability distribution of degree. Furthermore, two statistical properties of networks: normalized network structure entropy and cumulative probability of degree, are utilized to explore hourly variation in traffic flow. The results demonstrate these two statistical quantities express similar pattern to traffic flow parameters with morning and evening peak hours. Accordingly, we detect three traffic states: trough, peak and transitional hours, according to the correlation between two aforementioned properties. The classifying results of states can actually represent hourly fluctuation in traffic flow by analyzing annual average hourly values of traffic volume, occupancy and speed in corresponding hours.

  3. Complex function in the dynamic brain. Comment on “Understanding brain networks and brain organization” by Luiz Pessoa (United States)

    Anderson, Michael L.


    There is much to commend in this excellent overview of the progress we've made toward-and the challenges that remain for-developing an empirical framework for neuroscience that is adequate to the dynamic complexity of the brain [17]. Here I will limit myself first to highlighting the concept of dynamic affiliation, which I take to be the central feature of the functional architecture of the brain, and second to clarifying Pessoa's brief discussion of the ontology of cognition, to be sure readers appreciate this crucial issue.

  4. #consumingitall: Understanding The Complex Relationship Between Media Consumption And Eating Behaviors


    Albert, Stephanie L.


    Adolescents spend almost nine hours a day engaging with media. As a result, they are confronted with large amounts of obesogenic content that shapes their understanding of what are normal and acceptable eating behaviors. Utilizing primary data collected from a sample of 4,838 low-income, racially and ethnically diverse middle school students in Los Angeles County, I studied the effects of different types of media use (i.e., social media, TV/movies/videos, gaming, music, Internet) on dietary p...

  5. Application for 3d Scene Understanding in Detecting Discharge of Domesticwaste Along Complex Urban Rivers (United States)

    Ninsalam, Y.; Qin, R.; Rekittke, J.


    In our study we use 3D scene understanding to detect the discharge of domestic solid waste along an urban river. Solid waste found along the Ciliwung River in the neighbourhoods of Bukit Duri and Kampung Melayu may be attributed to households. This is in part due to inadequate municipal waste infrastructure and services which has caused those living along the river to rely upon it for waste disposal. However, there has been little research to understand the prevalence of household waste along the river. Our aim is to develop a methodology that deploys a low cost sensor to identify point source discharge of solid waste using image classification methods. To demonstrate this we describe the following five-step method: 1) a strip of GoPro images are captured photogrammetrically and processed for dense point cloud generation; 2) depth for each image is generated through a backward projection of the point clouds; 3) a supervised image classification method based on Random Forest classifier is applied on the view dependent red, green, blue and depth (RGB-D) data; 4) point discharge locations of solid waste can then be mapped by projecting the classified images to the 3D point clouds; 5) then the landscape elements are classified into five types, such as vegetation, human settlement, soil, water and solid waste. While this work is still ongoing, the initial results have demonstrated that it is possible to perform quantitative studies that may help reveal and estimate the amount of waste present along the river bank.

  6. Understanding the Complexities of Subnational Incentives in Supporting a National Market for Distributed Photovoltaics

    Energy Technology Data Exchange (ETDEWEB)

    Bush, B.; Doris, E.; Getman, D.


    Subnational policies pertaining to photovoltaic (PV) systems have increased in volume in recent years and federal incentives are set to be phased out over the next few. Understanding how subnational policies function within and across jurisdictions, thereby impacting PV market development, informs policy decision making. This report was developed for subnational policy-makers and researchers in order to aid the analysis on the function of PV system incentives within the emerging PV deployment market. The analysis presented is based on a 'logic engine,' a database tool using existing state, utility, and local incentives allowing users to see the interrelationships between PV system incentives and parameters, such as geographic location, technology specifications, and financial factors. Depending on how it is queried, the database can yield insights into which combinations of incentives are available and most advantageous to the PV system owner or developer under particular circumstances. This is useful both for individual system developers to identify the most advantageous incentive packages that they qualify for as well as for researchers and policymakers to better understand the patch work of incentives nationwide as well as how they drive the market.

  7. Physical Chemistry of Nanomedicine: Understanding the Complex Behaviors of Nanoparticles in Vivo (United States)

    Lane, Lucas A.; Qian, Ximei; Smith, Andrew M.; Nie, Shuming


    Nanomedicine is an interdisciplinary field of research at the interface of science, engineering, and medicine, with broad clinical applications ranging from molecular imaging to medical diagnostics, targeted therapy, and image-guided surgery. Despite major advances during the past 20 years, there are still major fundamental and technical barriers that need to be understood and overcome. In particular, the complex behaviors of nanoparticles under physiological conditions are poorly understood, and detailed kinetic and thermodynamic principles are still not available to guide the rational design and development of nanoparticle agents. Here we discuss the interactions of nanoparticles with proteins, cells, tissues, and organs from a quantitative physical chemistry point of view. We also discuss insights and strategies on how to minimize nonspecific protein binding, how to design multistage and activatable nanostructures for improved drug delivery, and how to use the enhanced permeability and retention effect to deliver imaging agents for image-guided cancer surgery.

  8. Understanding the genetic and epigenetic architecture in complex network of rice flowering pathways. (United States)

    Sun, Changhui; Chen, Dan; Fang, Jun; Wang, Pingrong; Deng, Xiaojian; Chu, Chengcai


    Although the molecular basis of flowering time control is well dissected in the long day (LD) plant Arabidopsis, it is still largely unknown in the short day (SD) plant rice. Rice flowering time (heading date) is an important agronomic trait for season adaption and grain yield, which is affected by both genetic and environmental factors. During the last decade, as the nature of florigen was identified, notable progress has been made on exploration how florigen gene expression is genetically controlled. In Arabidopsis expression of certain key flowering integrators such as FLOWERING LOCUS C (FLC) and FLOWERING LOCUS T (FT) are also epigenetically regulated by various chromatin modifications, however, very little is known in rice on this aspect until very recently. This review summarized the advances of both genetic networks and chromatin modifications in rice flowering time control, attempting to give a complete view of the genetic and epigenetic architecture in complex network of rice flowering pathways.

  9. Using design principles to foster understanding of complex health concepts in consumer informatics tools. (United States)

    Misra, Rupananda; Mark, Jessica H; Khan, Sharib; Kukafka, Rita


    Consumer health informatics tools can only be effective if patients comprehend their content. Optimal design may foster better patient comprehension and health literacy, which can improve health outcomes. We developed a patient-centric decision aid, Tailored Lifestyle Conversations (TLC), to help patients comprehend behavioral risks and set behavior change priorities for reducing risk of cardiovascular disease. The TLC decision aid was developed using a design framework based on Gestalt Principles of Perception. Further iteration was informed by qualitative user feedback. Preliminary analysis showed that the TLC decision aid helped patients understand their risk and supported their decisions on health behavior change. We identified design elements that supported patient comprehension, and other elements that were not effective, to inform iterative revision. This paper describes an effective methodology for the development of consumer health informatics tools that includes grounding in design principles complemented by iterative revision based on user testing and feedback.


    Directory of Open Access Journals (Sweden)

    Y. Ninsalam


    Full Text Available In our study we use 3D scene understanding to detect the discharge of domestic solid waste along an urban river. Solid waste found along the Ciliwung River in the neighbourhoods of Bukit Duri and Kampung Melayu may be attributed to households. This is in part due to inadequate municipal waste infrastructure and services which has caused those living along the river to rely upon it for waste disposal. However, there has been little research to understand the prevalence of household waste along the river. Our aim is to develop a methodology that deploys a low cost sensor to identify point source discharge of solid waste using image classification methods. To demonstrate this we describe the following five-step method: 1 a strip of GoPro images are captured photogrammetrically and processed for dense point cloud generation; 2 depth for each image is generated through a backward projection of the point clouds; 3 a supervised image classification method based on Random Forest classifier is applied on the view dependent red, green, blue and depth (RGB-D data; 4 point discharge locations of solid waste can then be mapped by projecting the classified images to the 3D point clouds; 5 then the landscape elements are classified into five types, such as vegetation, human settlement, soil, water and solid waste. While this work is still ongoing, the initial results have demonstrated that it is possible to perform quantitative studies that may help reveal and estimate the amount of waste present along the river bank.

  11. Navigating Special Education in Charter Schools Part I: Understanding Legal Roles and Responsibilities. Authorizing Matters. Issue Brief (United States)

    Rhim, Lauren Morando


    Special education and related services are mandated by the federal Individuals with Disabilities Education Act (IDEA) and related state special education policies. Policies and procedures associated with implementing IDEA can be complex, cumbersome and time consuming. IDEA is founded on the notion that a free appropriate public education is a…

  12. FuturICT: Participatory computing to understand and manage our complex world in a more sustainable and resilient way (United States)

    Helbing, D.; Bishop, S.; Conte, R.; Lukowicz, P.; McCarthy, J. B.


    We have built particle accelerators to understand the forces that make up our physical world. Yet, we do not understand the principles underlying our strongly connected, techno-socio-economic systems. We have enabled ubiquitous Internet connectivity and instant, global information access. Yet we do not understand how it impacts our behavior and the evolution of society. To fill the knowledge gaps and keep up with the fast pace at which our world is changing, a Knowledge Accelerator must urgently be created. The financial crisis, international wars, global terror, the spreading of diseases and cyber-crime as well as demographic, technological and environmental change demonstrate that humanity is facing serious challenges. These problems cannot be solved within the traditional paradigms. Moving our attention from a component-oriented view of the world to an interaction-oriented view will allow us to understand the complex systems we have created and the emergent collective phenomena characterising them. This paradigm shift will enable new solutions to long-standing problems, very much as the shift from a geocentric to a heliocentric worldview has facilitated modern physics and the ability to launch satellites. The FuturICT flagship project will develop new science and technology to manage our future in a complex, strongly connected world. For this, it will combine the power of information and communication technology (ICT) with knowledge from the social and complexity sciences. ICT will provide the data to boost the social sciences into a new era. Complexity science will shed new light on the emergent phenomena in socially interactive systems, and the social sciences will provide a better understanding of the opportunities and risks of strongly networked systems, in particular future ICT systems. Hence, the envisaged FuturICT flagship will create new methods and instruments to tackle the challenges of the 21st century. FuturICT could indeed become one of the most

  13. Understanding complexities in coupled dynamics of human-water and food security (United States)

    Usmani, M.; Kondal, A.; Lin, L.; Colwell, R. R.; Jutla, A.


    Traditional premise of food security is associated with satisfying human hunger by providing sufficient calories to population. Water is the key variable associated with the growth of crops, which is then used as a metric of success for abundance of food across globe. The current framework often negates complex coupled interaction between availability of food nutrients and human well-being (such as productivity, work efficiency, low birth weight, physical and mental growth). Our analysis suggests that 1 in 3 humans suffer from malnutrition across the globe. In last five decades, most of the countries have a decreasing availability trend in at least one of the twenty-three essential food nutrients required for human well-being. We argue that food security can only be achieved if information on use of water for crops and consumption of food must include availability of nutrients for humans. Here, we propose a new concept of "consumptive nutrients" that include constant feedback mechanism between water-human and societal processes- essential for growth, distribution and consumption of food nutrients. Using Ethiopia as a signature rain-fed agricultural region, we will show how decreasing precipitation has led to an increase in crop productivity, but decreased availability of nutrients for humans. This in turn has destabilizing impact on overall regional economy. We will demonstrate why inclusion of nutrients must be a part of discussion for ensuring food security to human population.

  14. Childhood disability in Turkana, Kenya: Understanding how carers cope in a complex humanitarian setting. (United States)

    Zuurmond, Maria; Nyapera, Velma; Mwenda, Victoria; Kisia, James; Rono, Hilary; Palmer, Jennifer


    Although the consequences of disability are magnified in humanitarian contexts, research into the difficulties of caring for children with a disability in such settings has received limited attention. Based on in-depth interviews with 31 families, key informants and focus group discussions in Turkana, Kenya, this article explores the lives of families caring for children with a range of impairments (hearing, vision, physical and intellectual) in a complex humanitarian context characterised by drought, flooding, armed conflict, poverty and historical marginalisation. The challenging environmental and social conditions of Turkana magnified not only the impact of impairment on children, but also the burden of caregiving. The remoteness of Turkana, along with the paucity and fragmentation of health, rehabilitation and social services, posed major challenges and created opportunity costs for families. Disability-related stigma isolated mothers of children with disabilities, especially, increasing their burden of care and further limiting their access to services and humanitarian programmes. In a context where social systems are already stressed, the combination of these factors compounded the vulnerabilities faced by children with disabilities and their families. The needs of children with disabilities and their carers in Turkana are not being met by either community social support systems or humanitarian aid programmes. There is an urgent need to mainstream disability into Turkana services and programmes.

  15. Putting Oneself in the Shoes of Another: Issues of Empathy and Intercultural Understanding in the Australian Geography Curriculum (United States)

    Harrison, Neil


    Geography is about the places that make up the world. A key focus of the new geography curriculum in Australia is on different ways of finding knowledge about those places. Yet there is limited demonstration in the curriculum and its elaborations of just how students might understand those places outside the realm of their own experience. In…

  16. Mind maps and network analysis to evaluate conceptualization of complex issues: A case example evaluating systems science workshops for childhood obesity prevention. (United States)

    Frerichs, Leah; Young, Tiffany L; Dave, Gaurav; Stith, Doris; Corbie-Smith, Giselle; Hassmiller Lich, Kristen


    Across disciplines, it is common practice to bring together groups to solve complex problems. Facilitators are often asked to help groups organize information about and better understand the problem in order to develop and prioritize solutions. However, despite existence of several methods to elicit and characterize how individuals and groups think about and conceptualize an issue, many are difficult to implement in practice-based settings where resources such as technology and participant time are limited and research questions shift over time. This paper describes an easy-to-implement diagramming technique for eliciting conceptualization and a flexible network analysis method for characterizing changes in both individual and group conceptualization. We use a case example to illustrate how we used the methods to evaluate African American adolescent's conceptual understanding of obesity before and after participating in a series of four systems thinking workshops. The methods produced results that were sensitive to changes in conceptualization that were likely driven by the specific activities employed during the workshop sessions. The methods appear strong for capturing salient levels of conceptualization at both individual and collective levels. The paper concludes with a critical examination of strengths and weaknesses of the methods and implications for future practice and research. Copyright © 2018 Elsevier Ltd. All rights reserved.

  17. Parapsoriasis: a complex issue. (United States)

    Sehgal, Virendra N; Srivastava, Govind; Aggarwal, Ashok K


    Parapsoriasis is a peculiar reaction pattern of the skin that appears to have a spectrum with small plaque parapsoriasis at one end and large plaque at the other. The spectrum between is bridged by pityriasis lichenoides, pityriasis lichenoides chronica, pityriasis lichenoides et varioliformis acuta, and lymphomatoid papulosis. The highlights of the clinical pattern of these diseases has been succinctly elucidated here to facilitate their recognition in day-to-day dermatologic practice. Their possible etiopathogenesis has been brought to focus in the light of changing concepts reported in the literature. Further, possible future implications demand a meticulous follow-up because, in a few cases, true neoplasms may ultimately develop. Treatment modalities are briefly discussed.

  18. Carbon-water Cycling in the Critical Zone: Understanding Ecosystem Process Variability Across Complex Terrain

    Energy Technology Data Exchange (ETDEWEB)

    Barnard, Holly [Univ. of Colorado, Boulder, CO (United States); Brooks, Paul [Univ. of Utah, Salt Lake City, UT (United States); Univ. of Arizona, Tucson, AZ (United States)


    One of the largest knowledge gaps in environmental science is the ability to understand and predict how ecosystems will respond to future climate variability. The links between vegetation, hydrology, and climate that control carbon sequestration in plant biomass and soils remain poorly understood. Soil respiration is the second largest carbon flux of terrestrial ecosystems, yet there is no consensus on how respiration will change as water availability and temperature co-vary. To address this knowledge gap, we use the variation in soil development and topography across an elevation and climate gradient on the Front Range of Colorado to conduct a natural experiment that enables us to examine the co-evolution of soil carbon, vegetation, hydrology, and climate in an accessible field laboratory. The goal of this project is to further our ability to combine plant water availability, carbon flux and storage, and topographically driven hydrometrics into a watershed scale predictive model of carbon balance. We hypothesize: (i) landscape structure and hydrology are important controls on soil respiration as a result of spatial variability in both physical and biological drivers: (ii) variation in rates of soil respiration during the growing season is due to corresponding shifts in belowground carbon inputs from vegetation; and (iii) aboveground carbon storage (biomass) and species composition are directly correlated with soil moisture and therefore, can be directly related to subsurface drainage patterns.

  19. Studying the complexity of change: toward an analytical framework for understanding deliberate social-ecological transformations

    Directory of Open Access Journals (Sweden)

    Michele-Lee Moore


    Full Text Available Faced with numerous seemingly intractable social and environmental challenges, many scholars and practitioners are increasingly interested in understanding how to actively engage and transform the existing systems holding such problems in place. Although a variety of analytical models have emerged in recent years, most emphasize either the social or ecological elements of such transformations rather than their coupled nature. To address this, first we have presented a definition of the core elements of a social-ecological system (SES that could potentially be altered in a transformation. Second, we drew on insights about transformation from three branches of literature focused on radical change, i.e., social movements, socio-technical transitions, and social innovation, and gave consideration to the similarities and differences with the current studies by resilience scholars. Drawing on these findings, we have proposed a framework that outlines the process and phases of transformative change in an SES. Future research will be able to utilize the framework as a tool for analyzing the alteration of social-ecological feedbacks, identifying critical barriers and leverage points and assessing the outcome of social-ecological transformations.

  20. Understanding the complexities of functional ability in Alzheimer's disease: more than just basic and instrumental factors. (United States)

    Kahle-Wrobleski, Kristin; Coley, Nicola; Lepage, Benoit; Cantet, Christelle; Vellas, Bruno; Andrieu, Sandrine


    Dementia of the Alzheimer's type (AD) is defined by both cognitive and functional decline; new criteria allow for identification of milder, non-functionally impaired patients. Understanding loss of autonomy in AD is essential, as later stages represent a significant burden and cost to patients, their families, and society. The purpose of the present analyses was to determine the factor structure of the Alzheimer's Disease Cooperative Study-Activities of Daily Living Scale (ADCS-ADL) in a cohort of AD patients. Baseline ADCS-ADL assessments of 734 AD patients from the PLASA study were included in an exploratory factor analysis (EFA). Because the ADCS-ADL was designed to assess change over time, change from baseline scores over 2 years were also analyzed using an EFA. Factorial solutions were evaluated based on cross-loading, non-loadings, and number of items per factor. Mean age at baseline was 79.3, mean MMSE was 19.8 and 73.3% of participants were female. Baseline data suggested a 4-factor solution that included factors for basic ADLs (BADLs), domestic/household activities, communication/engagement with the environment, and outside activities. The change scores EFA suggested a 2-factor solution of BADLs and instrumental ADLs (IADLs). Distinct factors of IADLs should be considered for further validation as areas of attention to catch early functional decline.

  1. Childhood disability in Turkana, Kenya: Understanding how carers cope in a complex humanitarian setting

    Directory of Open Access Journals (Sweden)

    Maria Zuurmond


    Full Text Available Background: Although the consequences of disability are magnified in humanitarian contexts, research into the difficulties of caring for children with a disability in such settings has received limited attention.Methods: Based on in-depth interviews with 31 families, key informants and focus group discussions in Turkana, Kenya, this article explores the lives of families caring for children with a range of impairments (hearing, vision, physical and intellectual in a complex humanitarian context characterised by drought, flooding, armed conflict, poverty and historical marginalisation.Results: The challenging environmental and social conditions of Turkana magnified not only the impact of impairment on children, but also the burden of caregiving. The remoteness of Turkana, along with the paucity and fragmentation of health, rehabilitation and social services, posed major challenges and created opportunity costs for families. Disability-related stigma isolated mothers of children with disabilities, especially, increasing their burden of care and further limiting their access to services and humanitarian programmes. In a context where social systems are already stressed, the combination of these factors compounded the vulnerabilities faced by children with disabilities and their families.Conclusion: The needs of children with disabilities and their carers in Turkana are not being met by either community social support systems or humanitarian aid programmes. There is an urgent need to mainstream disability into Turkana services and programmes.

  2. Understanding complex coacervation in serum albumin and pectin mixtures using a combination of the Boltzmann equation and Monte Carlo simulation. (United States)

    Li, Yunqi; Zhao, Qin; Huang, Qingrong


    A combination of turbidimetric titration, a sigmoidal Boltzmann equation approach and Monte Carlo simulation has been used to study the complex coacervation in serum albumin and pectin mixtures. The effects of the mass ratio of protein to polysaccharide on the critical pH values, the probability of complex coacervation and the electrostatic interaction from charge patches in serum albumin were investigated. Turbidimetric titration results showed an optimum pH for complex coacervation (pHm), which corresponded to the maximum turbidity in the protein/polysaccharide mixture. The pHm monotonically decreased as the ratio decreased, and could be fitted using the sigmoidal Boltzmann equation. It suggests that pHm could be a good ordering parameter to characterize the phase behavior associated with protein/polysaccharide complex coacervation. Qualitative understanding of pHm by taking into account the minimization of electrostatic interaction, as well as quantitative matching of pHm according to the concept of charge neutralization were both achieved. Our results suggest that the serum albumin/pectin complexes were ultimately neutralized by the partial charges originated from the titratable residues in protein and polysaccharide chains at pHm. The Monte Carlo simulation provided consistent phase boundaries for complex coacervation in the same system, and the intermolecular association strength was determined to be several kBT below the given ionic strength. The strongest binding site in the protein is convergent to the largest positive charge patch if pure electrostatic interaction was considered. Further inclusion of contribution from excluded volume resulted in the binding site distribution over five different positive charge patches at different protein/polysaccharide ratios and pH values. Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. Complex Systems Are More than the Sum of Their Parts: Using Integration to Understand Performance, Biomechanics, and Diversity. (United States)

    Kane, Emily A; Higham, Timothy E


    Organisms are comprised of many interacting parts, and an increased number or specialization of those parts leads to greater complexity and the necessity for increased integration (the ability of those parts to perform together and maintain a functioning organism). Although this idea is widely recognized among biologists, organisms are more tangibly studied when those parts are considered independently. This reductionist approach has successfully advanced our understanding of organisms' performance. However, performance of one system might (or might not) be dependent on performance of another system to achieve a relevant outcome, and the mechanism of this dependence is poorly understood. We synthesize the concepts of complexity and integration and discuss their application in a biomechanical context. Capture of prey by predatory fishes is used as an example to highlight the application of these ideas. We provide a theoretical framework for future hypotheses of integration and predict an "integration space" for fishes that is then populated with data extracted from the literature. Additionally, using the kinematics of prey-capture in two species of sculpin (Scorpaeniformes: Cottidae), we show that species exhibit multivariate integration in distinct ways, and that these differences add additional insight into ecological divergence that would not be apparent by considering systems independently. Finally, we discuss new insights into organismal performance gained through the study of integration as an emergent property of kinematic systems working together during a common task. Integration is rarely the trait of interest, but we show that future work should adopt a more holistic approach to understand why and how animals perform complex behaviors. © The Author 2015. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email:

  4. Geochemical assessments and classification of coal mine spoils for better understanding of potential salinity issues at closure. (United States)

    Park, Jin Hee; Li, Xiaofang; Edraki, Mansour; Baumgartl, Thomas; Kirsch, Bernie


    Coal mining wastes in the form of spoils, rejects and tailings deposited on a mine lease can cause various environmental issues including contamination by toxic metals, acid mine drainage and salinity. Dissolution of salt from saline mine spoil, in particular, during rainfall events may result in local or regional dispersion of salts through leaching or in the accumulation of dissolved salts in soil pore water and inhibition of plant growth. The salinity in coal mine environments is from the geogenic salt accumulations and weathering of spoils upon surface exposure. The salts are mainly sulfates and chlorides of calcium, magnesium and sodium. The objective of the research is to investigate and assess the source and mobility of salts and trace elements in various spoil types, thereby predicting the leaching behavior of the salts and trace elements from spoils which have similar geochemical properties. X-ray diffraction analysis, total digestion, sequential extraction and column experiments were conducted to achieve the objectives. Sodium and chloride concentrations best represented salinity of the spoils, which might originate from halite. Electrical conductivity, sodium and chloride concentrations in the leachate decreased sharply with increasing leaching cycles. Leaching of trace elements was not significant in the studied area. Geochemical classification of spoil/waste defined for rehabilitation purposes was useful to predict potential salinity, which corresponded with the classification from cluster analysis based on leaching data of major elements. Certain spoil groups showed high potential salinity by releasing high sodium and chloride concentrations. Therefore, the leaching characteristics of sites having saline susceptible spoils require monitoring, and suitable remediation technologies have to be applied.

  5. Know Your Client and Know Your Team: A Complexity Inspired Approach to Understanding Safe Transitions in Care

    Directory of Open Access Journals (Sweden)

    Deborah Tregunno


    Full Text Available Background. Transitions in care are one of the most important and challenging client safety issues in healthcare. This project was undertaken to gain insight into the practice setting realities for nurses and other health care providers as they manage increasingly complex care transitions across multiple settings. Methods. The Appreciative Inquiry approach was used to guide interviews with sixty-six healthcare providers from a variety of practice settings. Data was collected on participants’ experience of exceptional care transitions and opportunities for improving care transitions. Results. Nurses and other healthcare providers need to know three things to ensure safe care transitions: (1 know your client; (2 know your team on both sides of the transfer; and (3 know the resources your client needs and how to get them. Three themes describe successful care transitions, including flexible structures; independence and teamwork; and client and provider focus. Conclusion. Nurses often operate at the margins of acceptable performance, and flexibility with regulation and standards is often required in complex sociotechnical work like care transitions. Priority needs to be given to creating conditions where nurses and other healthcare providers are free to creatively engage and respond in ways that will optimize safe care transitions.

  6. Science-based decision-making on complex issues: Marcellus shale gas hydrofracking and New York City water supply. (United States)

    Eaton, Timothy T


    Complex scientific and non-scientific considerations are central to the pending decisions about "hydrofracking" or high volume hydraulic fracturing (HVHF) to exploit unconventional natural gas resources worldwide. While incipient plans are being made internationally for major shale reservoirs, production and technology are most advanced in the United States, particularly in Texas and Pennsylvania, with a pending decision in New York State whether to proceed. In contrast to the narrow scientific and technical debate to date, focused on either greenhouse gas emissions or water resources, toxicology and land use in the watersheds that supply drinking water to New York City (NYC), I review the scientific and technical aspects in combination with global climate change and other critical issues in energy tradeoffs, economics and political regulation to evaluate the major liabilities and benefits. Although potential benefits of Marcellus natural gas exploitation are large for transition to a clean energy economy, at present the regulatory framework in New York State is inadequate to prevent potentially irreversible threats to the local environment and New York City water supply. Major investments in state and federal regulatory enforcement will be required to avoid these environmental consequences, and a ban on drilling within the NYC water supply watersheds is appropriate, even if more highly regulated Marcellus gas production is eventually permitted elsewhere in New York State. Copyright © 2013 Elsevier B.V. All rights reserved.

  7. Understanding Spatially Complex Segmental and Branch Anatomy Using 3D Printing: Liver, Lung, Prostate, Coronary Arteries, and Circle of Willis. (United States)

    Javan, Ramin; Herrin, Douglas; Tangestanipoor, Ardalan


    Three-dimensional (3D) manufacturing is shaping personalized medicine, in which radiologists can play a significant role, be it as consultants to surgeons for surgical planning or by creating powerful visual aids for communicating with patients, physicians, and trainees. This report illustrates the steps in development of custom 3D models that enhance the understanding of complex anatomy. We graphically designed 3D meshes or modified imported data from cross-sectional imaging to develop physical models targeted specifically for teaching complex segmental and branch anatomy. The 3D printing itself is easily accessible through online commercial services, and the models are made of polyamide or gypsum. Anatomic models of the liver, lungs, prostate, coronary arteries, and the Circle of Willis were created. These models have advantages that include customizable detail, relative low cost, full control of design focusing on subsegments, color-coding potential, and the utilization of cross-sectional imaging combined with graphic design. Radiologists have an opportunity to serve as leaders in medical education and clinical care with 3D printed models that provide beneficial interaction with patients, clinicians, and trainees across all specialties by proactively taking on the educator's role. Complex models can be developed to show normal anatomy or common pathology for medical educational purposes. There is a need for randomized trials, which radiologists can design, to demonstrate the utility and effectiveness of 3D printed models for teaching simple and complex anatomy, simulating interventions, measuring patient satisfaction, and improving clinical care. Copyright © 2016 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

  8. Understanding titanium-catalysed radical-radical reactions: a DFT study unravels the complex kinetics of ketone-nitrile couplings. (United States)

    Streuff, Jan; Himmel, Daniel; Younas, Sara L


    The computational investigation of a titanium-catalysed reductive radical-radical coupling is reported. The results match the conclusions from an earlier experimental study and enable a further interpretation of the previously observed complex reaction kinetics. Furthermore, the interplay between neutral and cationic reaction pathways in titanium(iii)-catalysed reactions is investigated for the first time. The results show that hydrochloride additives and reaction byproducts play an important role in the respective equilibria. A full reaction profile is assembled and the computed activation barrier is found to be in reasonable agreement with the experiment. The conclusions are of fundamental importance to the field of low-valent titanium catalysis and the understanding of related catalytic radical-radical coupling reactions.

  9. Topological Characteristics of the Hong Kong Stock Market: A Test-based P-threshold Approach to Understanding Network Complexity (United States)

    Xu, Ronghua; Wong, Wing-Keung; Chen, Guanrong; Huang, Shuo


    In this paper, we analyze the relationship among stock networks by focusing on the statistically reliable connectivity between financial time series, which accurately reflects the underlying pure stock structure. To do so, we firstly filter out the effect of market index on the correlations between paired stocks, and then take a t-test based P-threshold approach to lessening the complexity of the stock network based on the P values. We demonstrate the superiority of its performance in understanding network complexity by examining the Hong Kong stock market. By comparing with other filtering methods, we find that the P-threshold approach extracts purely and significantly correlated stock pairs, which reflect the well-defined hierarchical structure of the market. In analyzing the dynamic stock networks with fixed-size moving windows, our results show that three global financial crises, covered by the long-range time series, can be distinguishingly indicated from the network topological and evolutionary perspectives. In addition, we find that the assortativity coefficient can manifest the financial crises and therefore can serve as a good indicator of the financial market development.

  10. Thousand Cankers Disease Complex: A Forest Health Issue that Threatens Juglans Species across the U.S.

    Directory of Open Access Journals (Sweden)

    Dixie A. Daniels


    Full Text Available Thousand Cankers Disease (TCD is a disease complex wherein the fungus (Geosmithia morbida is vectored by the walnut twig beetle (WTB, Pityophthorus juglandis. The disease causes mortality primarily of eastern black walnut (Juglans nigra, although other walnut and wingnut (Pterocarya species are also susceptible. Black walnut is native to the Eastern and Midwestern U.S. but is widely planted in western states. Total standing volume in both urban and forested settings is approximately 96 million cubic meters, and is valued at $539 billion. Although native to the Southwestern U.S., the range of WTB has expanded considerably. The spread of G. morbida coincides with that of WTB. TCD was introduced into Tennessee in 2010, and has spread to seven eastern states. Trees infected with TCD exhibit drought-like symptoms, making field detection difficult without molecular and/or morphological methods. The recently sequenced G. morbida genome will provide valuable research tools focused on understanding gene interactions between organisms involved in TCD and mechanisms of pathogenicity. With no chemical treatments available, quarantine and sanitation are preeminent options for slowing the spread of TCD, although biological control agents have been discovered. High levels of black walnut mortality due to TCD will have far-reaching implications for both eastern and western states.

  11. Understanding the dynamics of the Seguro Popular de Salud policy implementation in Mexico from a complex adaptive systems perspective. (United States)

    Nigenda, Gustavo; González-Robledo, Luz María; Juárez-Ramírez, Clara; Adam, Taghreed


    In 2003, Mexico's Seguro Popular de Salud (SPS), was launched as an innovative financial mechanism implemented to channel new funds to provide health insurance to 50 million Mexicans and to reduce systemic financial inequities. The objective of this article is to understand the complexity and dynamics that contributed to the adaptation of the policy in the implementation stage, how these changes occurred, and why, from a complex and adaptive systems perspective. A complex adaptive systems (CAS) framework was used to carry out a secondary analysis of data obtained from four SPS's implementation evaluations. We first identified key actors, their roles, incentives and power, and their responses to the policy and guidelines. We then developed a causal loop diagram to disentangle the feedback dynamics associated with the modifications of the policy implementation which we then analyzed using a CAS perspective. Implementation variations were identified in seven core design features during the first 10 years of implementation period, and in each case, the SPS's central coordination introduced modifications in response to the reactions of the different actors. We identified several CAS phenomena associated with these changes including phase transitions, network emergence, resistance to change, history dependence, and feedback loops. Our findings generate valuable lessons to policy implementation processes, especially those involving a monetary component, where the emergence of coping mechanisms and other CAS phenomena inevitably lead to modifications of policies and their interpretation by those who implement them. These include the difficulty of implementing strategies that aim to pool funds through solidarity among beneficiaries where the rich support the poor when there are no incentives for the rich to do so. Also, how resistance to change and history dependence can pose significant challenges to implementing changes, where the local actors use their significant power

  12. Enhancing health-care workers' understanding and thinking about people living with co-occurring mental health and substance use issues through consumer-led training. (United States)

    Roussy, Véronique; Thomacos, Nikos; Rudd, Annette; Crockett, Belinda


    Stigma and judgemental assumptions by health workers have been identified as key barriers to accessing health care for people living with co-occurring mental health and substance use issues (dual diagnosis). To evaluate the effectiveness of consumer-led training by people with dual diagnosis in improving the knowledge, understanding and role adequacy of community health staff to work with this consumer group. A controlled before-and-after study design with four waves of quantitative data collection was used. Qualitative data were collected to explore participants' views about training. Participants were staff from two community health services from Victoria, Australia. Recruitment occurred across various work areas: reception, oral health, allied health, counselling and health promotion. At baseline, all participants attended a 4-h clinician-led training session. The intervention consisted of a 3-h consumer-led training session, developed and delivered by seven individuals living with dual diagnosis. Outcome measures included understanding of dual diagnosis, participants' feelings of role adequacy and role legitimacy, personal views, and training outcomes and relevance. Consumer-led training was associated with a significant increase in understanding. The combination of clinician-led and consumer-led training was associated with a positive change in role adequacy. Consumer-led training is a promising approach to enhance primary health-care workers' understanding of the issues faced by dual-diagnosis consumers, with such positive effects persisting over time. Used alongside other organizational capacity building strategies, consumer-led training has the potential to help address stigma and judgemental attitudes by health workers and improve access to services for this consumer group. © 2013 John Wiley & Sons Ltd.

  13. Ecosystem function in complex mountain terrain: Combining models and long-term observations to advance process-based understanding (United States)

    Wieder, William R.; Knowles, John F.; Blanken, Peter D.; Swenson, Sean C.; Suding, Katharine N.


    Abiotic factors structure plant community composition and ecosystem function across many different spatial scales. Often, such variation is considered at regional or global scales, but here we ask whether ecosystem-scale simulations can be used to better understand landscape-level variation that might be particularly important in complex terrain, such as high-elevation mountains. We performed ecosystem-scale simulations by using the Community Land Model (CLM) version 4.5 to better understand how the increased length of growing seasons may impact carbon, water, and energy fluxes in an alpine tundra landscape. The model was forced with meteorological data and validated with observations from the Niwot Ridge Long Term Ecological Research Program site. Our results demonstrate that CLM is capable of reproducing the observed carbon, water, and energy fluxes for discrete vegetation patches across this heterogeneous ecosystem. We subsequently accelerated snowmelt and increased spring and summer air temperatures in order to simulate potential effects of climate change in this region. We found that vegetation communities that were characterized by different snow accumulation dynamics showed divergent biogeochemical responses to a longer growing season. Contrary to expectations, wet meadow ecosystems showed the strongest decreases in plant productivity under extended summer scenarios because of disruptions in hydrologic connectivity. These findings illustrate how Earth system models such as CLM can be used to generate testable hypotheses about the shifting nature of energy, water, and nutrient limitations across space and through time in heterogeneous landscapes; these hypotheses may ultimately guide further experimental work and model development.

  14. Science Outside the Lab: Helping Graduate Students in Science and Engineering Understand the Complexities of Science Policy. (United States)

    Bernstein, Michael J; Reifschneider, Kiera; Bennett, Ira; Wetmore, Jameson M


    Helping scientists and engineers challenge received assumptions about how science, engineering, and society relate is a critical cornerstone for macroethics education. Scientific and engineering research are frequently framed as first steps of a value-free linear model that inexorably leads to societal benefit. Social studies of science and assessments of scientific and engineering research speak to the need for a more critical approach to the noble intentions underlying these assumptions. "Science Outside the Lab" is a program designed to help early-career scientists and engineers understand the complexities of science and engineering policy. Assessment of the program entailed a pre-, post-, and 1 year follow up survey to gauge student perspectives on relationships between science and society, as well as a pre-post concept map exercise to elicit student conceptualizations of science policy. Students leave Science Outside the Lab with greater humility about the role of scientific expertise in science and engineering policy; greater skepticism toward linear notions of scientific advances benefiting society; a deeper, more nuanced understanding of the actors involved in shaping science policy; and a continued appreciation of the contributions of science and engineering to society. The study presents an efficacious program that helps scientists and engineers make inroads into macroethical debates, reframe the ways in which they think about values of science and engineering in society, and more thoughtfully engage with critical mediators of science and society relationships: policy makers and policy processes.

  15. Understanding the determinants of the complex interplay between cost-effectiveness and equitable impact in maternal and child mortality reduction. (United States)

    Chopra, Mickey; Campbell, Harry; Rudan, Igor


    One of the most unexpected outcomes arising from the efforts towards maternal and child mortality reduction is that all too often the objective success has been coupled with increased inequity in the population. The aim of this study is to analyze the determinants of the complex interplay between cost-effectiveness and equity and suggest strategies that will promote an impact on mortality that reduce population child health inequities. We developed a conceptual framework that exposes the nature of the links between the five key determinants that need to be taken into account when planning equitable impact. These determinants are: (i) efficiency of intervention scale-up (requires knowledge of differential increase in cost of intervention scale-up by equity strata in the population); (ii) effectiveness of intervention (requires understanding of differential effectiveness of interventions by equity strata in the population); (iii) the impact on mortality (requires knowledge of differential mortality levels by equity strata, and understanding the differences in cause composition of overall mortality in different equity strata); (iv) cost-effectiveness (compares the initial cost and the resulting impact on mortality); (v) equity structure of the population. The framework is presented visually as a four-quadrant graph. We use the proposed framework to demonstrate why the relationship between cost-effectiveness and equitable impact of an intervention cannot be intuitively predicted or easily planned. The relationships between the five determinants are complex, often nonlinear, context-specific and intervention-specific. We demonstrate that there will be instances when an equity-promoting approach, ie, trying to reach for the poorest and excluded in the population with health interventions, will also be the most cost-effective approach. However, there will be cases in which this will be entirely unfeasible, and where equity-neutral or even inequity-promoting approaches may

  16. Understanding Magmatic Timescales and Magma Dynamics in Proterozoic Anorthosites: a Geochronological Investigation of the Kunene Complex (Angola) (United States)

    Brower, A. M.; Corfu, F.; Bybee, G. M.; Lehmann, J.; Owen-Smith, T.


    The Kunene Anorthosite Complex, located in south west Angola, is one of the largest massif-type anorthosite intrusions on Earth, with an areal extent of at least 18 000 km2. Previous studies considered the Complex to consist of a series of coalesced plutons. However, the ages and relative emplacement sequence of these plutons are unknown. Understanding the relative timing of the pluton emplacement is crucial for understanding how these enigmatic magmas form and how they rise through the crust. Here we present new high precision U-Pb ID-TIMS ages (n=10) on zircons and baddeleyites for many of the coalesced plutons across the 300-km-long anorthositic complex. These new geochronological results reveal subtle variations in crystallization age between the coalesced plutons. There is no gradual age progression between plutons, but distinct groupings of ages (Fig.1). Age clusters of 1379.8 ± 2 Ma (n=5) occur north of the Red Granite NE-SW-striking intrusions, whereas in the south there is an older age grouping of 1390.4 ± 2.3 (n=3). Two additional ages of 1400.5 ± 1.3 in the centre and 1438.4 ± 1.1 Ma in the south east have been obtained. These results indicate that the Kunene anorthosites were emplaced over 60 Ma and may suggest long-lived magmatic systems and/or slowly ascending plutons. We also find a link between pluton composition and age. In general, leuconoritic domains are older than the leucotroctolitic domains. This may imply that the first pulses of magma received a greater degree of contamination, forcing the broadly basaltic magma to produce orthopyroxene as the main mafic phase. The later pulses receive less contamination as they ascend through the already partially melted crust, producing olivine as the mafic phase and deforming the older domains. This study reiterates the multiphase petrogenesis of Proterozoic anorthosites and sheds light on the assembly of crystal-rich magmas as they ascend through the crust.

  17. Developing Seventh Grade Students' Understanding of Complex Environmental Problems with Systems Tools and Representations: a Quasi-experimental Study (United States)

    Doganca Kucuk, Zerrin; Saysel, Ali Kerem


    A systems-based classroom intervention on environmental education was designed for seventh grade students; the results were evaluated to see its impact on the development of systems thinking skills and standard science achievement and whether the systems approach is a more effective way to teach environmental issues that are dynamic and complex. A quasi-experimental methodology was used to compare performances of the participants in various dimensions, including systems thinking skills, competence in dynamic environmental problem solving and success in science achievement tests. The same pre-, post- and delayed tests were used with both the comparison and experimental groups in the same public middle school in Istanbul. Classroom activities designed for the comparison group (N = 20) followed the directives of the Science and Technology Curriculum, while the experimental group (N = 22) covered the same subject matter through activities benefiting from systems tools and representations such as behaviour over time graphs, causal loop diagrams, stock-flow structures and hands-on dynamic modelling. After a one-month systems-based instruction, the experimental group demonstrated significantly better systems thinking and dynamic environmental problem solving skills. Achievement in dynamic problem solving was found to be relatively stable over time. However, standard science achievement did not improve at all. This paper focuses on the quantitative analysis of the results, the weaknesses of the curriculum and educational implications.

  18. Male Depression: Understanding the Issues (United States)

    ... the time? Drinking too much? These unhealthy coping strategies may be clues that you have male depression. ... Engage in activities you enjoy, such as ball games, fishing or a hobby. Health. Live a healthy ...

  19. The renewable energy industry in Massachussetts as a complex system: Developing a shared understanding for policy making (United States)

    Jones, Charles A.

    A model-based field study was conducted to understand the mental models of participants in the photovoltaic industry in Massachusetts, with the purpose of understanding of how that industry works as a complex system. Mental models of industry participants are important, both as the holders of the best system information and as the critical actors in any policy solution. Experts from manufacturing, installation, development, policy, and advocacy sectors were interviewed. The knowledge they conveyed was expressed as a set system dynamics models; these models were characterized, compared, and combined in order to answer the following research questions: What are the mental models of participants? How widely are mental models shared among participants? What is the combined model of the system? How accurate are these models? Given these models, what policies would lead to success? The system described by informants is revealed as one of distributed and embedded agency---actors have the ability to take meaningful action, but that action and its effects are limited by the complexity of the system and by the actions of other actors. Both the growth of the industry and constraints on the growth occur through dynamic processes, many however outside local control. Mental models are shared in clusters of informants, with some differences between these groupings. Informants vary on the level of aggregation needed to express their descriptions and on the most important dynamic force. However, many processes are commonly perceived across informants, they perceive the same system trajectories, and the behavior of the simulation models constructed from their mental models was similar. A combined model was constructed which included a full range of potential feedback loops within an abstracted version of the described system. Testing for policy using the combined model reveals that the structures necessary for growth are present, as expected. Under several reasonable conditions

  20. Creating creationists: The influence of 'issues framing' on our understanding of public perceptions of clash narratives between evolutionary science and belief. (United States)

    Elsdon-Baker, Fern


    Clash narratives relating to evolutionary science and personal belief are a recurrent theme in media or public space discourse. However, a 2009 British Council poll undertaken in 10 countries worldwide shows that the perception of a necessary clash between evolutionary worldviews and belief in a God is a minority viewpoint. How then does the popular conception that there is an ongoing conflict between evolution and belief in God arise? One contributing factor is the framing and categorization of creationism and evolutionism within large-scale surveys for use within media campaigns. This article examines the issue framing within four polls conducted in the United Kingdom and internationally between 2008 and 2013. It argues that by ignoring the complexity and range of perspectives individuals hold, or by framing evolutionary science as atheistic, we are potentially creating 'creationists' - including 'Islamic creationists' - both figuratively and literally. © The Author(s) 2015.

  1. Culturally Equipped for Socio-Scientific Issues? A comparative study on how teachers and students in mono- and multiethnic schools handle work with complex issues (United States)

    Ideland, Malin; Malmberg, Claes; Winberg, Mikael


    Socio-scientific issues (SSI) are not only said to increase students' interest in science, but they also strengthen the generic skills of teamwork, problem-solving, and media literacy. At the same time, these skills are prerequisites for successful work with SSI. The aim of the study is to analyze what happens when SSI are implemented in science classrooms with various degrees of ethnic diversity and socio-cultural status. We are also interested in knowing how teachers structure the SSI work from discourses on what suits different students. Quantitative and qualitative methods are combined, for example, questionnaires and ethnographic fieldwork, presented through partial least squares analysis and thick descriptions. We can notice discursive differences between 'Us' and 'The Other' and between mono- and multiethnic schools. In an earlier research, images of differences between the different student groups emerged, and we can find these in the results from the questionnaires. In an observation study, another pattern appeared that indicated similarities rather than differences between mono- and multiethnic classrooms. The students are first of all inside the discourse of 'the successful student.' Noteworthy is that the teachers' roles correspond better with the discourse than with how students actually act. The study also shows that SSI articulate a collision between different discourses on education: a discourse on differences between students in multi- and monoethnic classrooms; a discourse on how to become a successful student; and a discourse on the school's mission to educate participating citizens. It is suggested that schools should relate to, expose, and articulate discursive clashes that emerge when introducing new work forms.

  2. Epidemiology: Past, Present, and Future Impacts on Understanding Disease Dynamics and Improving Plant Disease Management-A Summary of Focus Issue Articles. (United States)

    Ojiambo, P S; Yuen, J; van den Bosch, F; Madden, L V


    Epidemiology has made significant contributions to plant pathology by elucidating the general principles underlying the development of disease epidemics. This has resulted in a greatly improved theoretical and empirical understanding of the dynamics of disease epidemics in time and space, predictions of disease outbreaks or the need for disease control in real-time basis, and tactical and strategic solutions to disease problems. Availability of high-resolution experimental data at multiple temporal and spatial scales has now provided a platform to test and validate theories on the spread of diseases at a wide range of spatial scales ranging from the local to the landscape level. Relatively new approaches in plant disease epidemiology, ranging from network to information theory, coupled with the availability of large-scale datasets and the rapid development of computer technology, are leading to revolutionary thinking about epidemics that can result in considerable improvement of strategic and tactical decision making in the control and management of plant diseases. Methods that were previously restricted to topics such as population biology or evolution are now being employed in epidemiology to enable a better understanding of the forces that drive the development of plant disease epidemics in space and time. This Focus Issue of Phytopathology features research articles that address broad themes in epidemiology including social and political consequences of disease epidemics, decision theory and support, pathogen dispersal and disease spread, disease assessment and pathogen biology and disease resistance. It is important to emphasize that these articles are just a sample of the types of research projects that are relevant to epidemiology. Below, we provide a succinct summary of the articles that are published in this Focus Issue .

  3. Identifying Clusters of Complex Urban–Rural Issues as Part of Policy Making Process Using a Network Analysis Approach: A Case Study in Bahía de Los Ángeles, Mexico

    Directory of Open Access Journals (Sweden)

    Javier Sandoval


    Full Text Available Improving human settlements diagnosis is a key factor in effective urban planning and the design of efficient policy making. In this paper, we illustrate how network theory concepts can be applied to reveal the topological structure of functional relationships in a network of heterogeneous urban–rural issues. This mapping is done using clustering algorithms and centrality value techniques. By analyzing emergent groups of urban–rural related issues, our methodology was applied to a rural community, considering in this exercise environmental matters and real estate interests as a way to better understand the structure of salient issues in the context of its urban development program design. Results show clusters that arrange themselves not by an obvious similarity in their constituent components, but by relations observed in urban–rural settings that hint on the issues that the urban development program must focus. Due to its complex nature, the classification of these emerging clusters and how they must be treated in traditional planning instruments is a new challenge that this novel methodology reveals.

  4. Teachers' understandings and enactments of social and environmental justice issues in the classroom: What's "critical" in the manufacturing of road-smart squirrels? (United States)

    Sammel, Alison J.

    How do five new teachers understand and enact counter-hegemonic pedagogies in their own classes? This study developed from this question. The question arose as I taught critical environmental education, a counter-hegemonic pedagogy, to preservice science teachers. I encouraged the exploration of social and environmental injustices and how they function to reproduce dominant economic agendas. To understand how five teachers, in the second year of their practice and my former students, made sense of the critical environmental education I taught them, I used Gadamer's hermeneutic phenomenology as my research frame. Gadamer argues that meaning develops through dialogue, so data collection occurred mainly through lively research conversations over leisurely dinners. As practicing teachers, the six of us jointly explored taken-for-granted meanings and actions in our everyday pedagogical experiences. In these conversations we made meaning (the hermeneutic aspect) of the lived experiences (phenomenological aspect) of incorporating critical environmental education into our practices. This led me to a deeper understanding and increased awareness of how science education reform agendas have influenced and shaped our individual science pedagogies. The analytic lens of critical education showed that these teachers were strongly influenced by the dominant science reform agenda. Regardless of the science curriculum, or the strong social and environmental beliefs some of these teachers held, they did not perceive the teaching of the social and environmental justice issues to be 'critical' or 'their job.' They demonstrated a belief that it was 'critical' to teach well-defined, "hard science" facts. Student success, hence teacher success, involved playing the academic game well and gaining long-term financial security. Re/viewing the data stories through the additional analytic lens of feminist poststructuralism, I saw how dominant discourse constructs the identity of teachers

  5. Scepticism and Doubt in Science and Science Education: The Complexity of Global Warming as a Socio-Scientific Issue (United States)

    Bryce, Tom G. K.; Day, Stephen P.


    This article looks critically at the complexity of the debate among climate scientists; the controversies in the science of global temperature measurement; and at the role played by "consensus." It highlights the conflicting perspectives figuring in the mass media concerned with climate change, arguing that science teachers should be…

  6. A Cross-Continental Study on Children's Drawings of Football Players: Implications for Understanding Key Issues and Controversies in Human Figure Drawings. (United States)

    Baluch, Bahman; Duffy, Linda J; Badami, Rokhsareh; Pereira, Elisangela C Ap


    Professionals examine various aspects of girls' and boys' drawings as a way of understanding their intelligence, personality and emotional state. However, the extent to which such measures could be universally generalised or attributed to a specific cultural norm is still a debatable issue. In the present study five key features of children's drawings namely: the size (height) of the drawings, profile or full face, figure in action or static, shaded or non-shaded and the nature of additional details were examined from a cross-cultural perspective, and by providing a topic (football) for which children's drawing of a human figure could provide opportunities for the latter indices to manifest and flourish. Children from three countries; England, Iran and Brazil, representing three continents took part in this study. The participants were asked to draw a football player from their own country and from the other participating countries. The results showed that Brazilian children differ from Iranian and English children by drawing significantly smaller figures and putting more football action in the drawings. Shading of the figure drawn was more prevalent amongst English children. Such findings have implications for the interpretation of key aspects of children's drawings in educational, clinical and therapeutic settings and from a universal vs. culturally-specific viewpoint.

  7. Soluble 1:1 complexes and insoluble 3:2 complexes - Understanding the phase-solubility diagram of hydrocortisone and γ-cyclodextrin

    DEFF Research Database (Denmark)

    Schönbeck, Christian; Madsen, Tobias Løvgren; Peters, Günther H.


    -cyclodextrin in solution and the solid phase. The drug-solubilizer interaction was also studied by isothermal titration calorimetry from which a precise value of the 1:1 binding constant (K 11 =4.01mM-1 at 20°C) was obtained. The formation of water-soluble 1:1 complexes is responsible for the initial increase...

  8. The Comparison of the Skill of Understanding Complex Syntax at Children Attending to a Preschool Education Institution (TRNC-TR Sample) (United States)

    Yazici, Elçin


    The current study was carried out to compare the skills of understanding complex syntax at children attending to preschool education institutions. In the current study, relational screening model, a model providing to determine the current study, was used. The working group of the study was made up of 224 children at the age of 4-5 attending to a…

  9. Nuclear inelastic scattering and density-functional-theory calculations on the understanding of the vibronic properties of polynuclear iron complexes

    International Nuclear Information System (INIS)

    Faus, Isabelle


    Transition metal complexes of 3d elements with an electronic configuration of d 4 to d 8 can show a temperature dependent spin transition. This process is called spin crossover (SCO) effect and describes the transition between two states, the low spin (LS) state and the high spin (HS) state. In the LS state the spin is as low as possible, caused by none or a minimal number of unpaired electrons. In the HS state the spin is as high as possible with a maximal number of unpaired electrons. Because of this bistability, SCO materials are promising candidates for innovative molecular storage devices. Directly related to the SCO effect is the cooperativity, which specifies the interaction of metal centers between molecules (intermolecular cooperativity) or in a molecule (intramolecular cooperativity). Cooperativity is of vital importance for the switching behavior of SCO complexes with broad hysteresis. Therefore, three dinuclear SCO complexes which show a varying degree of cooperativity due to different geometries of their bridging ligands were investigated. By means of nuclear inelastic scattering (NIS), it could be clarified whether it is possible to find intramolecular cooperative effects in the vibrational patterns of these complexes. With corresponding density functional theory (DFT) calculations, it was possible for all of the dinuclear complexes to correlate the experimental NIS bands to the corresponding molecular vibrational modes. In the LS-LS or HS-HS state of the three complexes two modes exist lying energetically close together, which show a similar movement of the whole complex, with only a difference in the movement of the iron atoms. Thereby, the irons are moving either in the same or in the opposite direction. For complexes with a high degree of cooperativity there are nearly exclusively small energy shifts between this kind of nearly twofold energetically degenerated modes (ΔE <7 cm -1 ), for the complex with a low degree of cooperativity there are

  10. Modeling wake effects in large wind farms in complex terrain: the problem, the methods and the issues

    DEFF Research Database (Denmark)

    Politis, E.S.; Prospathopoulos, J.; Cabezon, D.


    turbulence closures, are used. The wind turbines are modeled as momentum absorbers by means of their thrust coefficient through the actuator disk approach. Alternative methods for estimating the reference wind speed in the calculation of the thrust are tested. The work presented in this paper is part......Computational fluid dynamic (CFD) methods are used in this paper to predict the power production from entire wind farms in complex terrain and to shed some light into the wake flow patterns. Two full three-dimensional Navier–Stokes solvers for incompressible fluid flow, employing k - ε and k - ω...

  11. Stability constants important to the understanding of plutonium in environmental waters, hydroxy and carbonate complexation of PuO2+

    International Nuclear Information System (INIS)

    Bennett, D.A.; Lawrence Berkeley Lab., CA


    The formation constants for the reactions PuO 2 + + H 2 O = PuO 2 (OH) + H + and PuO 2 + + CO 3 2 = PuO 2 (CO 3 ) - were determined in aqueous sodium perchlorate solutions by laser-induced photoacoustic spectroscopy. The molar absorptivity of the PuO 2 + band at 569 nm decreased with increasing hydroxide concentration. Similarly, spectral changes occurred between 540 and 580 nm as the carbonate concentration was increased. The absorption data were analyzed by the non-linear least-squares program SQUAD to yield complexation constants. Using the specific ion interaction theory, both complexation constants were extrapolated to zero ionic strength. These thermodynamic complexation constants were combined with the oxidation-reduction potentials of Pu to obtain Eh versus pH diagrams. 120 refs., 35 figs., 12 tabs

  12. Scepticism and doubt in science and science education: the complexity of global warming as a socio-scientific issue (United States)

    Bryce, Tom G. K.; Day, Stephen P.


    This article looks critically at the complexity of the debate among climate scientists; the controversies in the science of global temperature measurement; and at the role played by consensus. It highlights the conflicting perspectives figuring in the mass media concerned with climate change, arguing that science teachers should be familiar with them, particularly given the sharply contested views likely to be brought into classroom discussion and the importance of developing intellectual scepticism and robust scientific literacy in students. We distinguish between rational scepticism and the pejorative meaning of the expression associated with attitudinal opposition to global warming—similar to the way in which Bauer (2006) contrasts micro- scepticism and macro- scepticism in reasoning generally. And we look closely and critically at the approaches which teachers might adopt in practice to teach about global warming at this difficult time.

  13. To Issue of Mathematical Management Methods Applied for Investment-Building Complex under Conditions of Economic Crisis (United States)

    Novikova, V.; Nikolaeva, O.


    In the article the authors consider a cognitive management method of the investment-building complex in the crisis conditions. The factors influencing the choice of an investment strategy are studied, the basic lines of the activity in the field of crisis-management from a position of mathematical modelling are defined. The general approach to decision-making on investment in real assets on the basis of the discrete systems based on the optimum control theory is offered. With the use of a discrete maximum principle the task in view of the decision is found. The numerical algorithm to define the optimum control is formulated by investments. Analytical decisions for the case of constant profitability of the basic means are obtained.

  14. Using a Complexity-Based Perspective to Better Understand the Relationships among Mentoring, School Conflicts, and Novice Retention (United States)

    Waterman, Sheryn Elaine Spencer


    In this study I used complexity-thinking, ecologically-based sustainable capacity-building, narrative methodology, and pragmatism to explore the relationships among mentoring, conflict, and novice retention. In order to explore these relationships, I constructed stories from my interviews with six mentor-novice dyads in a southeastern 9-12 high…

  15. The development of second-order social cognition and its relation with complex language understanding and working memory

    NARCIS (Netherlands)

    Arslan, Burcu; Hohenberger, Annette; Verbrugge, Rineke


    In this study, the development of second-order social cognition and its possible relationship with language and memory were investigated. For this reason two second-order false belief tasks (FBT_2), a short term memory task (WST), a complex working memory task (LST), a linguistic perspective-taking

  16. Use of biological priors enhances understanding of genetic architecture and genomic prediction of complex traits within and between dairy cattle breeds

    DEFF Research Database (Denmark)

    Fang, Lingzhao; Sahana, Goutam; Ma, Peipei


    sequence variants in Holstein (HOL) and Jersey (JER) cattle were analysed. We first carried out a post-GWAS analysis in a HOL training population to assess the degree of enrichment of the association signals in the gene regions defined by each GO term. We then extended the genomic best linear unbiased......BACKGROUND: A better understanding of the genetic architecture underlying complex traits (e.g., the distribution of causal variants and their effects) may aid in the genomic prediction. Here, we hypothesized that the genomic variants of complex traits might be enriched in a subset of genomic...

  17. Understanding the Complexity of the Lived Experiences of Foundation Degree Sport Lecturers within the Context of Further Education (United States)

    Aldous, David


    This paper provides an ethnographic account of the lived experiences of Further Education (FE) lecturers (N = 4) who are engaged in the transmission of pedagogic knowledge within a Foundation Degree. To further understand the experiences of the lecturers the paper draws upon Stones' quadripartite cycle of structuration. This conceptual and…

  18. On power consumption issues in FIR filters with application to communication receivers: complexity, word length, and switching activity

    Energy Technology Data Exchange (ETDEWEB)

    Havashki, Asghar


    Power consumption in CMOS VLSI circuits has in recent years become a major design constraint. This is in particular important for wireless networks, due to the limited life time of the batteries that wireless nodes are operating on. Orthogonal Frequency Division Multiplexing (OFDM) is one example of a technique which in recent years has become widely applied in wireless communication systems. However, the performance of OFDM and other spectrally efficient schemes depends, to a large extend, on advanced digital signal processing (DSP) and on the use of efficient and possibly adaptive resource allocation and transmission techniques. These in turn require that accurate estimates of the channel are available in the receiver and transmitter. However, accurate channel estimation of a time and frequency dispersive wireless fading channel calls for complex estimators, which might lead to significant power dissipation in such devices. Therefore, characterizing and analyzing power consumed by such devices under different channel conditions, and optimizing for power is important to reduce the overall power consumption of the system. In this thesis a certain chosen class of estimators, i.e., a linear FIR estimator, is considered, which is based on finite impulse response (FIR) filters. The work in this thesis considers the power related challenges in such estimators. The power consumed by such estimators depends, in part, on the complexity of the estimator, i.e., the length of the FIR filter. The filter length is one of the factors affecting the estimation accuracy. An analysis of the relation between the performance of such estimators and the required complexity for these devices under different channel conditions, i.e., in the presence of noise, is performed in this thesis. In this study we show that a small increase in this noise can lead to a considerable increase in the required estimator complexity if a given Normalized Mean Square Error (NMSE) performance for the

  19. Using a Virtual Tablet Machine to Improve Student Understanding of the Complex Processes Involved in Tablet Manufacturing. (United States)

    Mattsson, Sofia; Sjöström, Hans-Erik; Englund, Claire


    Objective. To develop and implement a virtual tablet machine simulation to aid distance students' understanding of the processes involved in tablet production. Design. A tablet simulation was created enabling students to study the effects different parameters have on the properties of the tablet. Once results were generated, students interpreted and explained them on the basis of current theory. Assessment. The simulation was evaluated using written questionnaires and focus group interviews. Students appreciated the exercise and considered it to be motivational. Students commented that they found the simulation, together with the online seminar and the writing of the report, was beneficial for their learning process. Conclusion. According to students' perceptions, the use of the tablet simulation contributed to their understanding of the compaction process.

  20. Soluble 1:1 complexes and insoluble 3:2 complexes - Understanding the phase-solubility diagram of hydrocortisone and γ-cyclodextrin. (United States)

    Schönbeck, Christian; Madsen, Tobias L; Peters, Günther H; Holm, René; Loftsson, Thorsteinn


    The molecular mechanisms underlying the drug-solubilizing properties of γ-cyclodextrin were explored using hydrocortisone as a model drug. The B S -type phase-solubility diagram of hydrocortisone with γ-cyclodextrin was thoroughly characterized by measuring the concentrations of hydrocortisone and γ-cyclodextrin in solution and the solid phase. The drug-solubilizer interaction was also studied by isothermal titration calorimetry from which a precise value of the 1:1 binding constant (K 11 =4.01mM -1 at 20°C) was obtained. The formation of water-soluble 1:1 complexes is responsible for the initial increase in hydrocortisone solubility while the precipitation of entities with a 3:2 ratio of γ-cyclodextrin:hydrocortisone is responsible for the plateau and the ensuing strong decrease in solubility once all solid hydrocortisone is used up. The complete phase-solubility diagram is well accounted for by a model employing the 1:1 binding constant and the solubility product of the precipitating 3:2 entity (K 32 S =5.51 mM 5 ). For such systems, a small surplus of γ-cyclodextrin above the optimum concentration may result in a significant decrease in drug solubility, and the implications for drug formulations are briefly discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Case Management Models in Permanent Supported Housing Programs for People With Complex Behavioral Issues Who Are Homeless. (United States)

    Clark, Colleen; Guenther, Christina C; Mitchell, Jessica N


    The purpose of this article is to examine two evidence-based models of case management for people with co-occurring disorders and histories of chronic homelessness and to better understand their roles in permanent supported housing. Critical Time Intervention and Assertive Community Treatment are examined in terms of key elements, how they assist in ending homelessness, as well as the role they play in an individual's recovery from co-occurring disorders. Participants in two supported housing programs were interviewed at baseline and 6 months. One program used Critical Time Intervention (n = 144) and the other used Assertive Community Treatment (n = 90). Staff in both programs were interviewed about their experiences and fidelity assessments were conducted for each program. Both programs operated at high levels of fidelity. Despite similar criteria for participation, there were significant differences between groups. Critical Time Intervention participants were older, were more likely to be male, were more likely to be homeless, and reported greater psychiatric symptoms and higher levels of substance use (all p's homelessness to stable housing; 88.6% of Assertive Community Treatment participants were homeless at baseline, while at 6 months 30% were homeless (p homeless at baseline, while 44.3% were homeless at 6 months (p homelessness to move to stable housing. Permanent supported housing seems to be an effective way to end homelessness among people with co-occurring disorders. Further research is needed to determine which case management models work most effectively with supported housing to help policy makers and program directors make informed decisions in developing these programs.

  2. Enhanced Systemic Understanding of the Information Environment in Complex Crisis Management - Analytical Concept, Version 1.0 (United States)


    comprises the dimensions of ‗ media literacy ‘ and ‗intercultural communicative competence‘63. Figure 25: Communicative Competence...competence‘ comprises the dimensions of ‗ media literacy ‘ and ‗intercultural communicative competence‘89. Figure: Communicative Competence ‗ Media literacy ‘ successfully using media and media-related technology: "We have defined media literacy as: ‗the ability to access, understand and create

  3. Understanding Free Radicals: Isolating Active Thylakoid Membranes and Purifying the Cytochrome b6f Complex for Superoxide Generation Studies

    Directory of Open Access Journals (Sweden)

    Jason Stofleth


    Full Text Available All life persists in an environment that is rich in molecular oxygen. The production of oxygen free radicals, or superoxide, is a necessary consequence of the biogenesis of energy in cells. Both mitochondrial and photosynthetic electron transport chains have been found to produce superoxide associated with cell differentiation, proliferation, and cell death, thereby contributing to the effects of aging. Aerobic respiration in mitochondria consumes oxygen, whereas photosynthesis in chloroplasts or cyanobacteria produces oxygen. The increased concentration of molecular oxygen may serve to allow greater availability for the production of superoxide by cytochrome bc complexes in photosynthetic membranes compared to those of mitochondrial membranes. The isolation of well-coupled chloroplasts, containing the cytochrome b6f complex of oxygenic photosynthesis, is a vital initial step in the process of comparing the rate of production of superoxide to those of the homologous cytochrome bc1 complex of aerobic respiration. It is necessary to determine if the isolated chloroplasts have retained their oxygengenerating capability after isolation by an oxygen evolution assay with a Clark-type electrode. A necessary second step, which is the isolation of cytochrome b6f from spinach, has yet to be successfully performed. Oxygen measurements taken from chloroplasts in the presence of the uncoupler, NH4Cl, exhibited a rate of oxygen evolution over three times greater at 344 +/- 18 μmol O2/mg Chlorophyll a/hr than the rate of oxygen evolution without uncoupler at 109 +/- 29 μmol O2/mg Chlorophyll a/hr. These data demonstrate that the technique used to isolate spinach chloroplasts preserves their light-driven electron-transport activity, making them reliable for future superoxide assays.

  4. Regional molecular and cellular differences in the female rabbit Achilles tendon complex: potential implications for understanding responses to loading. (United States)

    Huisman, Elise S; Andersson, Gustav; Scott, Alexander; Reno, Carol R; Hart, David A; Thornton, Gail M


    The aim of this study was: (i) to analyze the morphology and expression of extracellular matrix genes in six different regions of the Achilles tendon complex of intact normal rabbits; and (ii) to assess the effect of ovariohysterectomy (OVH) on the regional expression of these genes. Female New Zealand White rabbits were separated into two groups: (i) intact normal rabbits (n = 4); and (ii) OVH rabbits (n = 8). For each rabbit, the Achilles tendon complex was dissected into six regions: distal gastrocnemius (DG); distal flexor digitorum superficialis; proximal lateral gastrocnemius (PLG); proximal medial gastrocnemius; proximal flexor digitorum superficialis; and paratenon. For each of the regions, hematoxylin and eosin staining was performed for histological evaluation of intact normal rabbit tissues and mRNA levels for proteoglycans, collagens and genes associated with collagen regulation were assessed by real-time reverse transcription-quantitative polymerase chain reaction for both the intact normal and OVH rabbit tissues. The distal regions displayed a more fibrocartilaginous phenotype. For intact normal rabbits, aggrecan mRNA expression was higher in the distal regions of the Achilles tendon complex compared with the proximal regions. Collagen Type I and matrix metalloproteinase-2 expression levels were increased in the PLG compared to the DG in the intact normal rabbit tissues. The tendons from OVH rabbits had lower gene expressions for the proteoglycans aggrecan, biglycan, decorin and versican compared with the intact normal rabbits, although the regional differences of increased aggrecan expression in distal regions compared with proximal regions persisted. The tensile and compressive forces experienced in the examined regions may be related to the regional differences found in gene expression. The lower mRNA expression of the genes examined in the OVH group confirms a potential effect of systemic estrogen on tendon. © 2014 Anatomical Society.

  5. Avoiding genetic genocide: understanding good intentions and eugenics in the complex dialogue between the medical and disability communities. (United States)

    Miller, Paul Steven; Levine, Rebecca Leah


    The relationship between the medical and disability communities is complex and is influenced by historical, social, and cultural factors. Although clinicians, health-care researchers, and people with disabilities all work from the standpoint of the best interest of disabled individuals, the notion of what actually is "best" is often understood quite differently among these constituencies. Eugenics campaigns, legal restrictions on reproductive and other freedoms, and prenatal testing recommendations predicated on the lesser worth of persons with disabilities have all contributed toward the historic trauma experienced by the disability community, particularly with respect to medical genetics. One premise of personalized medicine is that different individuals require different solutions. Disabled persons' experiences are a reminder that these solutions can be best realized by maintaining awareness and sensitivity in a complex ethical and moral terrain. Geneticists should recognize that their research may have implications for those with disabilities; they should recognize the impact of the historical trauma of the eugenics movement, and seek to involve people with disabilities in discussions about policies that affect them. Dialogue can be messy and uncomfortable, but it is the only way to avoid the mistakes of the past and to ensure a more equitable, and healthful, future.

  6. Understanding Prenatal Tests (United States)

    ... Navigation Bar Home Current Issue Past Issues Understanding Prenatal Tests Past Issues / Winter 2008 Table of Contents ... be done before pregnancy or at the first prenatal visit. If there is Rh incompatibility, treatments can ...

  7. A reassessment of the potential for an alpha-mode containment failure and a review of the current understanding of broader fuel-coolant interaction issues. Second steam explosion review group workshop

    Energy Technology Data Exchange (ETDEWEB)

    Basu, S. [Nuclear Regulatory Commission, Washington, DC (United States); Ginsberg, T. [Brookhaven National Lab., Upton, NY (United States)


    This report summarizes the review and evaluation by experts of the current understanding of the molten fuel-coolant interaction (FCI) issues covering the complete spectrum of interactions, i.e., from mild quenching to very energetic interactions including those that could lead to the alpha-mode containment failure. Of the eleven experts polled, all but two concluded that the alpha-mode failure issue was resolved from a risk perspective, meaning that this mode of failure is of very low probability, that it is of little or no significance to the overall risk from a nuclear power plant, and that any further reduction in residual uncertainties is not likely to change the probability in an appreciable manner. To a lesser degree, discussions also took place on the broader FCI issues such as mild quenching of core melt during non-explosive FCI, and shock loading of lower head and ex-vessel support structures arising from explosive localized FCIs. These latter issues are relevant with regard to determining the efficacy of certain accident management strategies for operating reactors as well as for advanced light water reactors. The experts reviewed the status of understanding of the FCI phenomena in the context of these broader issues, identified residual uncertainties in the understanding, and recommended future research (both experimental and analytical) to reduce the uncertainties.

  8. A reassessment of the potential for an alpha-mode containment failure and a review of the current understanding of broader fuel-coolant interaction issues. Second steam explosion review group workshop

    International Nuclear Information System (INIS)

    Basu, S.; Ginsberg, T.


    This report summarizes the review and evaluation by experts of the current understanding of the molten fuel-coolant interaction (FCI) issues covering the complete spectrum of interactions, i.e., from mild quenching to very energetic interactions including those that could lead to the alpha-mode containment failure. Of the eleven experts polled, all but two concluded that the alpha-mode failure issue was resolved from a risk perspective, meaning that this mode of failure is of very low probability, that it is of little or no significance to the overall risk from a nuclear power plant, and that any further reduction in residual uncertainties is not likely to change the probability in an appreciable manner. To a lesser degree, discussions also took place on the broader FCI issues such as mild quenching of core melt during non-explosive FCI, and shock loading of lower head and ex-vessel support structures arising from explosive localized FCIs. These latter issues are relevant with regard to determining the efficacy of certain accident management strategies for operating reactors as well as for advanced light water reactors. The experts reviewed the status of understanding of the FCI phenomena in the context of these broader issues, identified residual uncertainties in the understanding, and recommended future research (both experimental and analytical) to reduce the uncertainties

  9. A model for understanding diagnostic imaging referrals and complex interaction processes within the bigger picture of a healthcare system

    International Nuclear Information System (INIS)

    Makanjee, Chandra R.; Bergh, Anne-Marie; Hoffmann, Willem A.


    Using experiences from the South African public healthcare system with limited resources, this review proposes a model that captures a holistic perspective of diagnostic imaging services embedded in a network of negotiated decision-making processes. Professional interdependency and interprofessional collaboration, cooperation and coordination are built around the central notion of integration in order to achieve a seamless transition through the continuum of various types of services needed to come to a diagnosis. Health-system role players interact with patients who enter the system from the perspective of their life-world. The distribution of diagnostic imaging services – within one setting or at multiple levels of care – demonstrates how fragments of information are filtered, interpreted and transformed at each point of care. The proposed model could contribute to alignment towards a common goal: services providing holistic quality of care within and beyond a complex healthcare system

  10. Intermolecular vibrations of the CO2-CS2 complex: Experiment and theory agree, but understanding remains challenging (United States)

    Dehghany, M.; Rezaei, Mojtaba; Moazzen-Ahmadi, N.; McKellar, A. R. W.; Brown, James; Wang, Xiao-Gang; Carrington, Tucker


    The infrared spectrum of the cross-shaped van der Waals complex CO2-CS2 is observed in the region of the CO2 ν3 fundamental band (≈2350 cm-1) using a tuneable diode laser to probe a pulsed supersonic slit jet expansion. Two combination bands are assigned, corresponding to the intermolecular torsion and CO2 bend modes, and their positions and rotational structure agree extremely well (torsional band is well-behaved, but the a-type CO2 bending band is highly unusual, with large shifts between the subband origins for Ka = 0, 2, and 4. The shifts may be rationalized as due to tunnelling effects and Ka-dependent perturbations from other intermolecular modes. But even though they are well predicted by our calculations, there is no simple qualitative explanation. The predicted low-lying planar slipped parallel isomer of CO2-CS2 is not observed.

  11. A preliminary investigation of the applicability of surface complexation modeling to the understanding of transportation cask weeping

    International Nuclear Information System (INIS)

    Granstaff, V.E.; Chambers, W.B.; Doughty, D.H.


    A new application for surface complexation modeling is described. These models, which describe chemical equilibria among aqueous and adsorbed species, have typically been used for predicting groundwater transport of contaminants by modeling the natural adsorbents as various metal oxides. Our experiments suggest that this type of modeling can also explain stainless steel surface contamination and decontamination mechanisms. Stainless steel transportation casks, when submerged in a spent fuel storage pool at nuclear power stations, can become contaminated with radionuclides such as 137 Cs, 134 Cs, and 60 Co. Subsequent release or desorption of these contaminants under varying environmental conditions occasionally results in the phenomenon known as open-quotes cask weeping.close quotes We have postulated that contaminants in the storage pool adsorb onto the hydrous metal oxide surface of the passivated stainless steel and are subsequently released (by conversion from a fixed to a removable form) during transportation, due to varying environmental factors, such as humidity, road salt, dirt, and acid rain. It is well known that 304 stainless steel has a chromium enriched passive surface layer; thus its adsorption behavior should be similar to that of a mixed chromium/iron oxide. To help us interpret our studies of reversible binding of dissolved metals on stainless steel surfaces, we have studied the adsorption of Co +2 on Cr 2 O 3 . The data are interpreted using electrostatic surface complexation models. The FITEQL computer program was used to obtain the model binding constants and site densities from the experimental data. The MINTEQA2 computer speciation model was used, with the fitted constants, in an attempt to validate this approach

  12. Teachers' Understandings of Curriculum Adaptations for Learners with Learning Difficulties in Primary Schools in Botswana: Issues and Challenges of Inclusive Education (United States)

    Otukile-Mongwaketse, Mpho; Mangope, Boitumelo; Kuyini, Ahmed Bawa


    This paper derives from research carried out in a number of Botswana primary schools on teachers' understanding of curriculum adaptations for learners who experience learning difficulties (LD) as part of implementing inclusive education. Teachers' understanding play a crucial role in how they make curriculum accessible for learners with LD during…

  13. Understanding the Globalization of Intelligence

    DEFF Research Database (Denmark)

    Svendsen, Adam David Morgan

    cooperation ('liaison'), as it occurs in both theory and practice. Reflecting a complex coexistence plurality of several different and overlapping concepts in action, the challenging process of the globalization of intelligence emerges as essential for complex issue management purposes during a globalized era......"This book provides an introduction to the complexities of contemporary Western Intelligence and its dynamics during an era of globalization. Towards an understanding of the globalization of intelligence process, Svendsen focuses on the secretive phenomenon of international or foreign intelligence...

  14. Formation of complexes between hematite nanoparticles and a non-conventional galactomannan gum. Toward a better understanding on interaction processes. (United States)

    Busch, Verónica M; Loosli, Fréderic; Santagapita, Patricio R; Buera, M Pilar; Stoll, Serge


    The physicochemical characteristics of hematite nanoparticles related to their size, surface area and reactivity make them useful for many applications, as well as suitable models to study aggregation kinetics. For several applications (such as remediation of contaminated groundwater) it is crucial to maintain the stability of hematite nanoparticle suspensions in order to assure their arrival to the target place. The use of biopolymers has been proposed as a suitable environmentally friendly option to avoid nanoparticle aggregation and assure their stability. The aim of the present work was to investigate the formation of complexes between hematite nanoparticles and a non-conventional galactomannan (vinal gum--VG) obtained from Prosopis ruscifolia in order to promote hematite nanoparticle coating with a green biopolymer. Zeta potential and size of hematite nanoparticles, VG dispersions and the stability of their mixtures were investigated, as well as the influence of the biopolymer concentration and preparation method. DLS and nanoparticle tracking analysis techniques were used for determining the size and the zeta-potential of the suspensions. VG showed a polydispersed size distribution (300-475 nm Z-average diameter, 0.65 Pdi) and a negative zeta potential (between -1 and -12 mV for pH2 and 12, respectively). The aggregation of hematite nanoparticles (3.3 mg/L) was induced by the addition of VG at lower concentrations than 2mg/L (pH5.5). On the other hand, hematite nanoparticles were stabilized at concentrations of VG higher than 2 mg/L. Several phenomena between hematite nanoparticles and VG were involved: steric effects, electrostatic interactions, charge neutralization, charge inversion and polymer bridging. The process of complexation between hematite nanoparticles and the biopolymer was strongly influenced by the preparation protocols. It was concluded that the aggregation, dispersion, and stability of hematite nanoparticles depended on biopolymer

  15. Associations between speech understanding and auditory and visual tests of verbal working memory: Effects of linguistic complexity, task, age and hearing loss

    Directory of Open Access Journals (Sweden)

    Sherri L. Smith


    Full Text Available Listeners with hearing loss commonly report having difficulty understanding speech, particularly in noisy environments. Their difficulties could be due to auditory and cognitive processing problems. Performance on speech-in-noise tests has been correlated with reading working memory span (RWMS, a measure often chosen to avoid the effects of hearing loss. If the goal is to assess the cognitive consequences of listeners’ auditory processing abilities, however, then listening working memory span (LWMS could be a more informative measure. Some studies have examined the effects of different degrees and types of masking on working memory, but less is known about the demands placed on working memory depending on the linguistic complexity of the target speech or the task used to measure speech understanding in listeners with hearing loss. Compared to RWMS, LWMS measures using different speech targets and maskers may provide a more ecologically valid approach. To examine the contributions of RWMS and LWMS to speech understanding, we administered two working memory measures (a traditional RWMS measure and a new LWMS measure, and a battery of tests varying in the linguistic complexity of the speech materials, the presence of babble masking, and the task. Participants were a group of younger listeners with normal hearing and two groups of older listeners with hearing loss (n = 24 per group. There was a significant group difference and a wider range in performance on LWMS than on RWMS. There was a significant correlation between both working memory measures only for the oldest listeners with hearing loss. Notably, there were only few significant correlations among the working memory and speech understanding measures. These findings suggest that working memory measures reflect individual differences that are distinct from those tapped by these measures of speech understanding.

  16. Associations between speech understanding and auditory and visual tests of verbal working memory: effects of linguistic complexity, task, age, and hearing loss. (United States)

    Smith, Sherri L; Pichora-Fuller, M Kathleen


    Listeners with hearing loss commonly report having difficulty understanding speech, particularly in noisy environments. Their difficulties could be due to auditory and cognitive processing problems. Performance on speech-in-noise tests has been correlated with reading working memory span (RWMS), a measure often chosen to avoid the effects of hearing loss. If the goal is to assess the cognitive consequences of listeners' auditory processing abilities, however, then listening working memory span (LWMS) could be a more informative measure. Some studies have examined the effects of different degrees and types of masking on working memory, but less is known about the demands placed on working memory depending on the linguistic complexity of the target speech or the task used to measure speech understanding in listeners with hearing loss. Compared to RWMS, LWMS measures using different speech targets and maskers may provide a more ecologically valid approach. To examine the contributions of RWMS and LWMS to speech understanding, we administered two working memory measures (a traditional RWMS measure and a new LWMS measure), and a battery of tests varying in the linguistic complexity of the speech materials, the presence of babble masking, and the task. Participants were a group of younger listeners with normal hearing and two groups of older listeners with hearing loss (n = 24 per group). There was a significant group difference and a wider range in performance on LWMS than on RWMS. There was a significant correlation between both working memory measures only for the oldest listeners with hearing loss. Notably, there were only few significant correlations among the working memory and speech understanding measures. These findings suggest that working memory measures reflect individual differences that are distinct from those tapped by these measures of speech understanding.

  17. Associations between speech understanding and auditory and visual tests of verbal working memory: effects of linguistic complexity, task, age, and hearing loss (United States)

    Smith, Sherri L.; Pichora-Fuller, M. Kathleen


    Listeners with hearing loss commonly report having difficulty understanding speech, particularly in noisy environments. Their difficulties could be due to auditory and cognitive processing problems. Performance on speech-in-noise tests has been correlated with reading working memory span (RWMS), a measure often chosen to avoid the effects of hearing loss. If the goal is to assess the cognitive consequences of listeners’ auditory processing abilities, however, then listening working memory span (LWMS) could be a more informative measure. Some studies have examined the effects of different degrees and types of masking on working memory, but less is known about the demands placed on working memory depending on the linguistic complexity of the target speech or the task used to measure speech understanding in listeners with hearing loss. Compared to RWMS, LWMS measures using different speech targets and maskers may provide a more ecologically valid approach. To examine the contributions of RWMS and LWMS to speech understanding, we administered two working memory measures (a traditional RWMS measure and a new LWMS measure), and a battery of tests varying in the linguistic complexity of the speech materials, the presence of babble masking, and the task. Participants were a group of younger listeners with normal hearing and two groups of older listeners with hearing loss (n = 24 per group). There was a significant group difference and a wider range in performance on LWMS than on RWMS. There was a significant correlation between both working memory measures only for the oldest listeners with hearing loss. Notably, there were only few significant correlations among the working memory and speech understanding measures. These findings suggest that working memory measures reflect individual differences that are distinct from those tapped by these measures of speech understanding. PMID:26441769

  18. The Climate Change-Road Safety-Economy Nexus: A System Dynamics Approach to Understanding Complex Interdependencies

    Directory of Open Access Journals (Sweden)

    Mehdi Alirezaei


    Full Text Available Road accidents have the highest externality costs to society and to the economy, even when compared to the externality damages associated with air emissions and oil dependency. Road safety is one of the most complicated topics, which involves many interdependencies, and so, a sufficiently thorough analysis of roadway safety will require a novel system-based approach in which the associated feedback relationships and causal effects are given appropriate consideration. The factors affecting accident frequency and severity are highly dependent on economic parameters, environmental factors and weather conditions. In this study, we try to use a system dynamics modeling approach to model the climate change-road safety-economy nexus, thereby investigating the complex interactions among these important areas by tracking how they affect each other over time. For this purpose, five sub-models are developed to model each aspect of the overall nexus and to interact with each other to simulate the overall system. As a result, this comprehensive model can provide a platform for policy makers to test the effectiveness of different policy scenarios to reduce the negative consequences of traffic accidents and improve road safety.

  19. Understanding the complex determinants of height and adiposity in disadvantaged daycare preschoolers in Salvador, NE Brazil through structural equation modelling. (United States)

    Lander, Rebecca L; Williams, Sheila M; Costa-Ribeiro, Hugo; Mattos, Angela P; Barreto, Danile L; Houghton, Lisa A; Bailey, Karl B; Lander, Alastair G; Gibson, Rosalind S


    Earlier we reported on growth and adiposity in a cross-sectional study of disadvantaged Brazilian preschoolers. Here we extend the work on these children, using structural equation modelling (SEM) to gather information on the complex relationships between the variables influencing height and adiposity. We hope this information will help improve the design and effectiveness of future interventions for preschoolers. In 376 preschoolers aged 3-6 years attending seven philanthropic daycares in Salvador, we used SEM to examine direct and indirect relationships among biological (sex, ethnicity, birth order, maternal height and weight), socio-economic, micronutrient (haemoglobin, serum selenium and zinc), and environmental (helminths, de-worming) variables on height and adiposity, as reflected by Z-scores for height-for-age (HAZ) and body mass index (BMIZ). Of the children, 11 % had HAZ  1. Of their mothers, 8 % had short stature, and 50 % were overweight or obese. Based on standardized regression coefficients, significant direct effects (p children.

  20. Understanding pulp delignification by laccase-mediator systems through isolation and characterization of lignin-carbohydrate complexes. (United States)

    Du, Xueyu; Li, Jiebing; Gellerstedt, Göran; Rencoret, Jorge; Del Río, José C; Martínez, Angel T; Gutiérrez, Ana


    The effects and mechanism of pulp delignification by laccases in the presence of redox mediators have been investigated on unbleached eucalyptus kraft pulp treated with laccases from Pycnoporus cinnabarinus (PcL) and Myceliophthora thermophila (MtL) and 1-hydroxybenzotriazole (HBT) and methyl syringate (MeS) as mediators, respectively. Determination of the corrected κ number in eucalyptus pulps after the enzymatic treatments revealed that the PcL-HBT system exhibited a more remarkable delignification effect than the MtL-MeS system. To obtain further insight, lignin-carbohydrate complexes were fractionated and subsequently characterized by nuclear magnetic resonance, thioacidolysis (followed by gas chromatography and size exclusion chromatography), and pyrolysis-gas chromatography-mass spectrometry (pyrolysis-GC-MS) analyses before and after the enzymatic treatments and their controls. We can conclude that the laccase-mediator treatments altered the lignin structures in such a way that more lignin was recovered in the xylan-lignin fractions, as shown by Klason lignin estimation, with smaller amounts of both syringyl (S) and guaiacyl (G) uncondensed units, as shown by thioacidolysis and gas chromatography, especially after the PcL-HBT treatment. The laccase-mediator treatment produced oxidation at Cα and cleavage of Cα and Cβ bonds in pulp lignin, as shown by pyrolysis-GC-MS. The general mechanism of residual lignin degradation in the pulp by laccase-mediator treatments is discussed in light of the results obtained.

  1. Understanding reflection behavior as a key for interpreting complex signals in FBRM monitoring of microparticle preparation processes. (United States)

    Vay, Kerstin; Friess, Wolfgang; Scheler, Stefan


    The application of focused beam reflectance measurement (FBRM) was studied in a larger scale PLGA microparticle preparation process for monitoring changes of the particle size and the particles' surface properties. Further understanding how these parameters determine the chord length distribution (CLD) was gained by means of single object measurements and data of monodisperse microparticles. It was evaluated how the FBRM signal is influenced by the surface characteristics of the tested materials and the measuring conditions. Particles with good scattering properties provided comparable values for the CLD and the particle size distribution. Translucent particles caused an overestimation of the particle size by FBRM, whereas the values for transparent emulsion droplets were too low. Despite a strong dependence of FBRM results on the optical properties of the samples, it is a beneficial technique for online monitoring of microparticle preparation processes. The study demonstrated how changing reflection properties can be used to monitor structural changes during the solidification of emulsion droplets and to detect process instabilities by FBRM. Copyright © 2012 Elsevier B.V. All rights reserved.

  2. Toward an analytical framework for understanding complex social-ecological systems when conducting environmental impact assessments in South Africa

    Directory of Open Access Journals (Sweden)

    Rebecca Bowd


    counterpoint to established approaches and could contribute to improving the quality of EIAs with respect to the complex SESs that characterize the developing world.

  3. Resistance Switching in Complex Oxides: Improvements in Understanding and Function for Use as Non-Volatile Memory (United States)

    Young, Kristina Garrison


    Pro0.7Ca0.3MnO3 (PCMO) is a complex oxide that is studied for use as a non-volatile memory with potential to replace flash-type memory. PCMO functions as a resistive random access memory (RRAM) whose memory function is due to an oxygen vacancy concentration change that occurs in the top interface of the PCMO during the application of an electric field. The concentration of the oxygen ions/vacancies in this top interface region significantly affects the resistance seen in a simple thin film device. The electric field required to move ions/vacancies within PCMO is generated by a short (ns), low voltage (few V) pulse. During the pulse a high current is seen that is not commensurate with the resistance seen after the removal of the pulse. Additionally, after the removal of the pulse there is a degradation of the resistance state set by the pulse. The high current seen during the pulse has been explored using electrical characterization techniques and is believed to be due to quantum mechanical tunneling through the high resistance interface region. Modeling of conduction values confirms that quantum mechanical tunneling is the source of the high current. The degradation of the state after the removal of the pulse has been improved through the nanostructure modification of the PCMO film. A thin (barrier layer was placed immediately below the interface of the PCMO minimizing the back diffusion of ions/vacancies after removal of the pulse. The modification improved the EPIR ratio, fatigue and retention in PCMO.

  4. Hypoxia monitoring activities within the FP7 EU-project HYPOX: diverse approaches to understand a complex phenomenon (United States)

    Janssen, F.; Waldmann, C.; Boetius, A.


    Hypoxic conditions in aquatic systems and the occurrence of 'dead zones' increase worldwide due to man-made eutrophication and global warming with consequences for biodiversity, ecosystem functions and services such as fisheries, aquaculture and tourism. Monitoring of hypoxia and its consequences has to (1) account for the appropriate temporal and spatial scales, (2) separate anthropogenic from natural drivers and long-term trends from natural variations, (3) assess ecosystem response, (4) use modeling tools for generalization and prediction, and (5) share data and obtained knowledge. In 2009 the EU FP7 project HYPOX ( started out as a pioneering attempt to improve and integrate hypoxia observation capacities addressing these requirements. Target ecosystems selected for HYPOX cover a broad range of settings (e.g., hydrography, oxygenation status, biological activity, anthropogenic impact) and differ in their sensitivity towards change. Semi-enclosed basins with permanent anoxia (Black Sea, Baltic Sea), are included as well as seasonally or locally hypoxic land-locked systems (fjords, lagoons, lakes) and open ocean systems with high sensitivity to global warming (North Atlantic - Arctic transition). Adopted monitoring approaches involve autonomous, cabled, and shipboard instruments and include static and profiling moorings, benthic observatories, drifters, as well as classical CTD surveys. In order to improve observatory performance, project activities encompass developments of oxygen sensors as well as calibration procedures and technologies to reduce biofouling. Modeling and data assimilation are used to synthesize findings, to obtain an in-depth understanding of hypoxia causes and consequences, and to improve forecasting capacities. For integration of the collected information into a global oxygen observing system, results are disseminated through the HYPOX portal following GEOSS data sharing principles. This presentation will give an overview of

  5. Understanding the addiction cycle: a complex biology with distinct contributions of genotype vs. sex at each stage. (United States)

    Wilhelm, C J; Hashimoto, J G; Roberts, M L; Sonmez, M K; Wiren, K M


    Ethanol abuse can lead to addiction, brain damage and premature death. The cycle of alcohol addiction has been described as a composite consisting of three stages: intoxication, withdrawal and craving/abstinence. There is evidence for contributions of both genotype and sex to alcoholism, but an understanding of the biological underpinnings is limited. Utilizing both sexes of genetic animal models with highly divergent alcohol withdrawal severity, Withdrawal Seizure-Resistant (WSR) and Withdrawal Seizure-Prone (WSP) mice, the distinct contributions of genotype/phenotype and of sex during addiction stages on neuroadaptation were characterized. Transcriptional profiling was performed to identify expression changes as a consequence of chronic intoxication in the medial prefrontal cortex. Significant expression differences were identified on a single platform and tracked over a behaviorally relevant time course that covered each stage of alcohol addiction; i.e., after chronic intoxication, during peak withdrawal, and after a defined period of abstinence. Females were more sensitive to ethanol with higher fold expression differences. Bioinformatics showed a strong effect of sex on the data structure of expression profiles during chronic intoxication and at peak withdrawal irrespective of genetic background. However, during abstinence, differences were observed instead between the lines/phenotypes irrespective of sex. Confirmation of identified pathways showed distinct inflammatory signaling following intoxication at peak withdrawal, with a pro-inflammatory phenotype in females but overall suppression of immune signaling in males. Combined, these results suggest that each stage of the addiction cycle is influenced differentially by sex vs. genetic background and support the development of stage- and sex-specific therapies for alcohol withdrawal and the maintenance of sobriety. Published by Elsevier Ltd.

  6. Understanding complex exposure history of Mount Hampton, West Antarctica using cosmogenic 3He, 21Ne and 10Be in olivine (United States)

    Carracedo, Ana; Rodes, Angel; Stuart, Finlay; Smellie, John


    Combining stable and radioactive cosmogenic nuclides is an established tool for revealing the complexities of long-term landscape development. To date most studies have concentrated on 21Ne and 10Be in quartz. We have combined different chemical protocols for extraction of cosmogenic 10Be from olivine, and measured concentrations in olivine from lherzolite xenoliths from the peak of Mount Hampton (~3,200 m), an 11 Ma shield volcano on the West Antarctic rift flank. We combine this data with cosmogenic 3He (and 21Ne) in the olivines in order to unravel the long-term environmental history of the region. The mean 3He/21Ne ratio (1.98 ± 0.22) is consistent with the theoretical value and previous determinations. 10Be/3He ratios (0.012 to 0.018) are significantly lower than the instantaneous production ratio (~0.045). The data are consistent with 1-3 Ma of burial. The altitude of the volcano rules out over-topping of the peak by the West Antarctic Ice Sheet only possible burial could be generated by the growth of an ice cap although this contradicts the absence of evidence for ice cover. The 3He-10Be data can also be generated during episodic erosion of the volcanic ash over the last few million years. The data requires a minimum depth of 1 to 2.5 m for the samples during a minimum age of 5 Ma and maximum long-term erosion rate of ~0.5 m/Ma with at least one erosive episode reflecting short-term erosion rate of ~7 m/Ma that would have brought the samples into the surface during the last ~350 ka. Erosion in this type of landscape could be related to interglacial periods where cryostatic erosion can occur generating an increase in the erosion rate. This study shows that episodic erosion can produce stable-radioactive cosmogenic isotope systematics that are similar to those generated by exposure-burial cycles.

  7. Complexity explained

    CERN Document Server

    Erdi, Peter


    This book explains why complex systems research is important in understanding the structure, function and dynamics of complex natural and social phenomena. Readers will learn the basic concepts and methods of complex system research.

  8. The Holocene history of the North American Monsoon: 'known knowns' and 'known unknowns' in understanding its spatial and temporal complexity (United States)

    Metcalfe, Sarah E.; Barron, John A.; Davies, Sarah J.


    Evidence for climatic change across the North American Monsoon (NAM) and adjacent areas is reviewed, drawing on continental and marine records and the application of climate models. Patterns of change at 12,000, 9000, 6000 and 4000 cal yr BP are presented to capture the nature of change from the Younger Dryas (YD) and through the mid-Holocene. At the YD, conditions were cooler overall, wetter in the north and drier in the south, while moving into the Holocene wetter conditions became established in the south and then spread north as the NAM strengthened. Until c. 8000 cal yr BP, the Laurentide Ice Sheet influenced precipitation in the north by pushing the Bermuda High further south. The peak extent of the NAM seems to have occurred around 6000 cal yr BP. 4000 cal yr BP marks the start of important changes across the NAM region, with drying in the north and the establishment of the clear differences between the summer-rain dominated south and central areas and the north, where winter rain is more important. This differentiation between south and north is crucial to understanding many climate responses across the NAM. This increasing variability is coincident with the declining influence of orbital forcing. 4000 cal yr BP also marks the onset of significant anthropogenic activity in many areas. For the last 2000 years, the focus is on higher temporal resolution change, with strong variations across the region. The Medieval Climate Anomaly (MCA) is characterised by centennial scale ‘megadrought’ across the southwest USA, associated with cooler tropical Pacific SSTs and persistent La Niña type conditions. Proxy data from southern Mexico, Central America and the Caribbean reveal generally wetter conditions, whereas records from the highlands of central Mexico and much of the Yucatan are typified by long -term drought. The Little Ice Age (LIA), in the north, was characterised by cooler, wetter winter conditions that have been linked with increased

  9. Methodology issues in implementation science. (United States)

    Newhouse, Robin; Bobay, Kathleen; Dykes, Patricia C; Stevens, Kathleen R; Titler, Marita


    Putting evidence into practice at the point of care delivery requires an understanding of implementation strategies that work, in what context and how. To identify methodological issues in implementation science using 4 studies as cases and make recommendations for further methods development. Four cases are presented and methodological issues identified. For each issue raised, evidence on the state of the science is described. Issues in implementation science identified include diverse conceptual frameworks, potential weaknesses in pragmatic study designs, and the paucity of standard concepts and measurement. Recommendations to advance methods in implementation include developing a core set of implementation concepts and metrics, generating standards for implementation methods including pragmatic trials, mixed methods designs, complex interventions and measurement, and endorsing reporting standards for implementation studies.

  10. Progress on resolution of major surety issues

    International Nuclear Information System (INIS)

    Bell, C.R.; Boudreau, J.M.


    This paper presents a summary of the major surety issues (safety, environmental protection, sageguards, reliability, quality assurance) that have been identified during Phase I of the SP-100 Program and the progress that has been made in analyzing the most important of these issues in the context of the conceptual design effort. These issues have been identified as inadvertent criticality, toxic material release and dispersion, radiation exposure following end-of-life reentry, potential diversion of special nuclear material, failure to achieve end-of-life neutronic shutdown, and structural predictability for end-of-life re-entry or boost. Because of the complexity of these issues, a simplified conservative approach was taken during Phase I. Progress on these issues has been mainly in the area of increased understanding of the issues, identification of design features to resolve the issues, and quantitative evaluations of the surety characteristics of the various design concepts

  11. Insight to structural subsite recognition in plant thiol protease-inhibitor complexes : Understanding the basis of differential inhibition and the role of water

    Directory of Open Access Journals (Sweden)

    Mukhopadhayay Bishnu P


    Full Text Available Abstract Background This work represents an extensive MD simulation / water-dynamics studies on a series of complexes of inhibitors (leupeptin, E-64, E-64-C, ZPACK and plant cysteine proteases (actinidin, caricain, chymopapain, calotropin DI of papain family to understand the various interactions, water binding mode, factors influencing it and the structural basis of differential inhibition. Results The tertiary structure of the enzyme-inhibitor complexes were built by visual interactive modeling and energy minimization followed by dynamic simulation of 120 ps in water environment. DASA study with and without the inhibitor revealed the potential subsite residues involved in inhibition. Though the interaction involving main chain atoms are similar, critical inspection of the complexes reveal significant differences in the side chain interactions in S2-P2 and S3-P3 pairs due to sequence differences in the equivalent positions of respective subsites leading to differential inhibition. Conclusion The key finding of the study is a conserved site of a water molecule near oxyanion hole of the enzyme active site, which is found in all the modeled complexes and in most crystal structures of papain family either native or complexed. Conserved water molecules at the ligand binding sites of these homologous proteins suggest the structural importance of the water, which changes the conventional definition of chemical geometry of inhibitor binding domain, its shape and complimentarity. The water mediated recognition of inhibitor to enzyme subsites (Pn...H2O....Sn of leupeptin acetyl oxygen to caricain, chymopapain and calotropinDI is an additional information and offer valuable insight to potent inhibitor design.

  12. What's in a Model? Issues in the Use of Simulation Models to Analyze Student Understanding: A Reaction to Ohlsson, Ernst, and Rees. (United States)

    Schoenfeld, Alan H.


    Reacts to Ohlsson, Ernst, and Rees' paper by initially discussing the costs of methodology that utilizes artificial intelligence (AI) to model cognitive processes. Raises three concerns with the paper: insufficient clarification of the meaning of conceptual versus procedural understanding of base-10 subtraction; realism of the learning model; and…

  13. Toward an Understanding of the Mental Health and Substance Abuse Issues of Rural and Migrant Ethnic Minorities: A Search for Common Experiences. (United States)

    Ryan, Robert A.; Trimble, Joseph E.

    The current reversal of the rural to urban migration trend among Blacks, American Indians, and Hispanics will create a myriad of coping and adaptation problems for the urban to rural migrant and the rural nonmigrant as well. It is possible to gain a partial understanding of the likely problems by reviewing studies of the ethnic minorities' rural…

  14. Understanding the complexity of trans fatty acid reduction in the American diet: American Heart Association Trans Fat Conference 2006: report of the Trans Fat Conference Planning Group. (United States)

    Eckel, Robert H; Borra, Susan; Lichtenstein, Alice H; Yin-Piazza, Shirley Y


    A 2-day forum was convened to discuss the current status and future implications of reducing trans fatty acids without increasing saturated fats in the food supply while maintaining functionality and consumer acceptance of packaged, processed, and prepared foods. Attendees represented the agriculture and oilseed industry and oil processing, food manufacturing, food service, government, food technology, and health and nutrition disciplines. Presentations included food science behind fatty acid technology, the health science of dietary fatty acids, alternatives to trans fatty acids, and the use of alternatives in food manufacturing and food service. The reduction of trans fatty acids in the food supply is a complex issue involving interdependent and interrelated stakeholders. Actions to reduce trans fatty acids need to carefully consider both intended and unintended consequences related to nutrition and public health. The unintended consequence of greatest concern is that fats and oils high in saturated fats, instead of the healthier unsaturated fats, might be used to replace fats and oils with trans fatty acids. Many different options of alternative oils and fats to replace trans fatty acids are available or in development. Decisions on the use of these alternatives need to consider availability, health effects, research and development investments, reformulated food quality and taste, supply-chain management, operational modifications, consumer acceptance, and cost. The conference demonstrated the value of collaboration between the food industry and health and nutrition professionals, and this conference model should be used to address other food development, processing, and/or technology issues.

  15. GEM Plate Boundary Simulations for the Plate Boundary Observatory: A Program for Understanding the Physics of Earthquakes on Complex Fault Networks via Observations, Theory and Numerical Simulation (United States)

    Rundle, J. B.; Rundle, P. B.; Klein, W.; de sa Martins, J.; Tiampo, K. F.; Donnellan, A.; Kellogg, L. H.

    The last five years have seen unprecedented growth in the amount and quality of geodetic data collected to characterize crustal deformation in earthquake-prone areas such as California and Japan. The installation of the Southern California Integrated Geodetic Network (SCIGN) and the Bay Area Regional Deformation (BARD) network are two examples. As part of the recently proposed Earthscope NSF/GEO/EAR/MRE initiative, the Plate Boundary Observatory (PBO) plans to place more than a thousand GPS, strainmeters, and deformation sensors along the active plate boundary of the western coast of the United States, Mexico and Canada ( The scientific goals of PBO include understanding how tectonic plates interact, together with an emphasis on understanding the physics of earthquakes. However, the problem of understanding the physics of earthquakes on complex fault networks through observations alone is complicated by our inability to study the problem in a manner familiar to laboratory scientists, by means of controlled, fully reproducible experiments. We have therefore been motivated to construct a numerical simulation technology that will allow us to study earthquake physics via numerical experiments. To be considered successful, the simulations must not only produce observables that are maximally similar to those seen by the PBO and other observing programs, but in addition the simulations must provide dynamical predictions that can be falsified by means of observations on the real fault networks. In general, the dynamical behavior of earthquakes on complex fault networks is a result of the interplay between the geometric structure of the fault network and the physics of the frictional sliding process. In constructing numerical simulations of a complex fault network, we will need to solve a variety of problems, including the development of analysis techniques (also called data mining), data assimilation, space-time pattern definition

  16. Complex Systems: An Introduction

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 9. Complex Systems: An Introduction - Anthropic Principle, Terrestrial Complexity, Complex Materials. V K Wadhawan. General Article Volume 14 Issue 9 September 2009 pp 894-906 ...

  17. Emerging issues in environmental cracking in hot water

    International Nuclear Information System (INIS)

    Andresen, P.L.; Morra, M.M.


    Extensive research and engineering application efforts have been made to understand and manage environmentally assisted cracking (EAC) in high temperature water. EAC is a complex phenomena involving dozens of important parameters, and important issues continue to emerge as careful studies have been performed. This paper summarizes a number of emerging issues, and highlights the need for improvements in experimental sophistication and for deeper probing into the nature and importance of these emerging issues. (author)

  18. Understanding why an active video game intervention did not improve motor skill and physical activity in children with developmental coordination disorder: A quantity or quality issue? (United States)

    Howie, Erin K; Campbell, Amity C; Abbott, Rebecca A; Straker, Leon M


    Active video games (AVGs) have been identified as a novel strategy to improve motor skill and physical activity in clinical populations. A recent cross-over randomized trial found AVGs to be ineffective at improving motor skill and physical activity in the home-environment for children with or at-risk for developmental coordination disorder (DCD). The study purpose was to better understand why the intervention had been ineffective by examining the quantity and quality of AVG play during an AVG intervention for children with or at-risk for DCD. Participants (n=21, ages 9-12) completed the 16 week AVG intervention. Detailed quantitative and qualitative data were systematically triangulated to obtain the quantity of exposure (AVG exposure over time, patterns of exposure) and quality of use (game selection, facilitators and barriers to play). The median AVG dose (range 30-35min/day) remained relatively stable across the intervention and met the prescribed dose. Play quality was impacted by game selection, difficulty playing games, lack of time, illness, technical difficulties and boredom. The ineffectiveness of a home-based AVG intervention may be due to quality of play. Strategies to improve the quality of game play may help realize the potential benefits of AVGs as a clinical tool for children with DCD. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Challenges and issues with streptozotocin-induced diabetes - A clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics. (United States)

    Goyal, Sameer N; Reddy, Navya M; Patil, Kalpesh R; Nakhate, Kartik T; Ojha, Shreesh; Patil, Chandragouda R; Agrawal, Yogeeta O


    Streptozotocin (STZ) has been extensively used over the last three decades to induce diabetes in various animal species and to help screen for hypoglycemic drugs. STZ induces clinical features in animals that resemble those associated with diabetes in humans. For this reason STZ treated animals have been used to study diabetogenic mechanisms and for preclinical evaluation of novel antidiabetic therapies. However, the physiochemical characteristics and associated toxicities of STZ are still major obstacles for researchers using STZ treated animals to investigate diabetes. Another major challenges in STZ-induced diabetes are sustaining uniformity, suitability, reproducibility and induction of diabetes with minimal animal lethality. Lack of appropriate use of STZ was found to be associated with increased mortality and animal suffering. During STZ use in animals, attention should be paid to several factors such as method of preparation of STZ, stability, suitable dose, route of administration, diet regimen, animal species with respect to age, body weight, gender and the target blood glucose level used to represent hyperglycemia. Therefore, protocol for STZ-induced diabetes in experimental animals must be meticulously planned. This review highlights specific skills and strategies involved in the execution of STZ-induced diabetes model. The present review aims to provide insight into diabetogenic mechanisms of STZ, specific toxicity of STZ with its significance and factors responsible for variations in diabetogenic effects of STZ. Further this review also addresses ways to minimize STZ-induced mortality, suggests methods to improve STZ-based experimental models and best utilize them for experimental studies purported to understand diabetes pathogenesis and preclinical evaluation of drugs. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  20. 'It's a very complicated issue here': understanding the limited and declining use of manual vacuum aspiration for postabortion care in Malawi: a qualitative study. (United States)

    Cook, Sinead; de Kok, Bregje; Odland, Maria Lisa


    Malawi has one of the highest maternal mortality ratios in the world. Unsafe abortions are an important contributor to Malawi's maternal mortality and morbidity, where abortion is illegal except to save the woman's life. Postabortion care (PAC) aims to reduce adverse consequences of unsafe abortions, in part by treating incomplete abortions. Although global and national PAC policies recommend manual vacuum aspiration (MVA) for treatment of incomplete abortion, usage in Malawi is low and appears to be decreasing, with sharp curettage being used in preference. There is limited evidence regarding what influences rejection of recommended PAC innovations. Hence, drawing on Greenhalgh et al. 's (2004. Diffusion of innovations in service organizations: systematic review and recommendations. Milbank Quarterly 82: 581-629.) diffusion of healthcare innovation framework, this qualitative study aimed to investigate factors contributing to the limited and declining use of MVA in Malawi. Semi-structured interviews with 17 PAC providers in a central hospital and a district hospital indicate that a range of factors coalesce and influence PAC and MVA use in Malawi. Factors pertain to four main domains: the system (shortages of material and human resources; lack of training, supervision and feedback), relationships (power dynamics; expected job roles), the health workers (attitudes towards abortion and PAC; prioritization of PAC) and the innovation (perceived risks and benefits of MVA use). Effective and sustainable PAC policy must adopt a broader people-centred health systems approach which considers all these factors, their interactions and the wider socio-cultural, legal and political context of abortion and PAC. The study showed the value of using Greenhalgh et al. 's (2004. Diffusion of innovations in service organizations: systematic review and recommendations. Milbank Quarterly 82: 581-629.) framework to consider the complex interaction of factors surrounding innovation use

  1. On the Concept Image of Complex Numbers (United States)

    Nordlander, Maria Cortas; Nordlander, Edvard


    A study of how Swedish students understand the concept of complex numbers was performed. A questionnaire was issued reflecting the student view of own perception. Obtained answers show a variety of concept images describing how students adopt the concept of complex numbers. These concept images are classified into four categories in order to…

  2. Measuring Student Teachers' Understandings and Self-Awareness of Sustainability (United States)

    Birdsall, Sally


    Understanding sustainability is important, as people need to cope with issues associated with over-population and over-consumption. Education is seen as a key strategy to assist with the development of people's understandings of this complex concept, which could then lead to them being able to make more sustainable lifestyle decisions. In order to…

  3. Teaching Teaching & Understanding Understanding

    DEFF Research Database (Denmark)


    "Teaching Teaching & Understanding Understanding" is a 19-minute award-winning short-film about teaching at university and higher-level educational institutions. It is based on the "Constructive Alignment" theory developed by Prof. John Biggs. The film delivers a foundation for understanding what...

  4. Complex networks an algorithmic perspective

    CERN Document Server

    Erciyes, Kayhan


    Network science is a rapidly emerging field of study that encompasses mathematics, computer science, physics, and engineering. A key issue in the study of complex networks is to understand the collective behavior of the various elements of these networks.Although the results from graph theory have proven to be powerful in investigating the structures of complex networks, few books focus on the algorithmic aspects of complex network analysis. Filling this need, Complex Networks: An Algorithmic Perspective supplies the basic theoretical algorithmic and graph theoretic knowledge needed by every r

  5. Understanding Maple

    CERN Document Server

    Thompson, Ian


    Maple is a powerful symbolic computation system that is widely used in universities around the world. This short introduction gives readers an insight into the rules that control how the system works, and how to understand, fix, and avoid common problems. Topics covered include algebra, calculus, linear algebra, graphics, programming, and procedures. Each chapter contains numerous illustrative examples, using mathematics that does not extend beyond first-year undergraduate material. Maple worksheets containing these examples are available for download from the author's personal website. The book is suitable for new users, but where advanced topics are central to understanding Maple they are tackled head-on. Many concepts which are absent from introductory books and manuals are described in detail. With this book, students, teachers and researchers will gain a solid understanding of Maple and how to use it to solve complex mathematical problems in a simple and efficient way.

  6. Liability Issues

    International Nuclear Information System (INIS)

    O’Donoghue, K.


    Nuclear liability conventions try to provide a set of rules to govern third party liability. Not all States are parties to one of the existing liability conventions. There are a number of reasons why individual States may choose not to join one of the existing conventions. These include limits of compensation, jurisdiction issues, complexity, cost and definition of damage among others. This paper looks at the existing conventions and identifies some of the main issues in the existing conventions which prevent some States from signing them. The paper attempts to tease out some of the perceived gaps in the existing conventions and give a brief description of the reasons why non-Contracting Parties have difficulty with the provisions of the conventions. The paper recognizes that there has been work done in this area previously by the International Expert Group on Nuclear Liability (INLEX) and others to try to develop the existing frameworks to enhance global adherence by nuclear and non-nuclear States to an effective nuclear liability regime. (author)

  7. Licensing issues

    International Nuclear Information System (INIS)

    Roberts, J.P.; Desell, L.J.; Birch, M.L.; Berkowitz, L.; Bader, J.F.


    To provide guidance for the Department of Energy's (DOE) Civilian Radioactive Waste Management Program, the Nuclear Regulatory Commission (NRC) has issued a draft regulatory guide on the Format and Content for the License Application for the High-Level Waste Repository (FCRG). To facilitate the development of the FCRG, NRC suggested that DOE use the draft guide as the basis for preparing an annotated outline for a license application. DOE is doing so using an iterative process called the Annotated Outline Initiative. DOE;s use of the Initiative will assist in achieving the desired incorporation of actual experience in the FCRG, contribute to the development of shared interpretation and understanding of NRC regulations, and provide other important programmatic benefits described in this paper

  8. Understanding Information Culture: Conceptual and Implementation Issues

    Directory of Open Access Journals (Sweden)

    Oliver, Gillian


    Full Text Available Information culture is a concept with multiple and sometimes conflicting definitions. Nevertheless at a time when social and cognitive aspects of information and communication systems are recognized as being of similar significance as the technological functionality, the concept of information culture is demonstrating considerable value. This paper explains the concept of information culture and considers its value from two main perspectives: firstly as providing an analytical tool, and secondly as a means of providing practitioners with insight and sensitivity to the organisational contexts of their workplaces.

  9. Understanding China's Demographic Dividends and Labor Issue (United States)

    Peng, Xizhe


    One of the major concerns about the one-child policy is its negative impact on the current and future labor force in China. People have talked about the Lewis Turning Point and the end of demographic dividends. Some of these arguments, however, can be misleading. The working-age population (ages 15 to 59) can be treated as the potential labor…

  10. Understanding librarians communication is the issue

    CERN Document Server

    Hull, Barbara


    Aimed at professionals and trainee professionals within the library and information service (LIS) fields, this book reminds the reader of the frequently ignored communication-gulf between the professional and the layman, and in particular the lack of true communication between LIS professionals and the user. It focuses especially on 'non-standard' users, such as non-native speakers or those with some disability. The author provides accessible examples of good practice, assesses their degree of success and suggests further ways to improve performance in information provision.written by a "poach

  11. Understanding the Minimum Wage: Issues and Answers. (United States)

    Employment Policies Inst. Foundation, Washington, DC.

    This booklet, which is designed to clarify facts regarding the minimum wage's impact on marketplace economics, contains a total of 31 questions and answers pertaining to the following topics: relationship between minimum wages and poverty; impacts of changes in the minimum wage on welfare reform; and possible effects of changes in the minimum wage…

  12. Predicting Effects of Climate Change on Habitat Suitability of Red Spruce (Picea rubens Sarg. in the Southern Appalachian Mountains of the USA: Understanding Complex Systems Mechanisms through Modeling

    Directory of Open Access Journals (Sweden)

    Kyung Ah Koo


    Full Text Available Alpine, subalpine and boreal tree species, of low genetic diversity and adapted to low optimal temperatures, are vulnerable to the warming effects of global climate change. The accurate prediction of these species’ distributions in response to climate change is critical for effective planning and management. The goal of this research is to predict climate change effects on the distribution of red spruce (Picea rubens Sarg. in the Great Smoky Mountains National Park (GSMNP, eastern USA. Climate change is, however, conflated with other environmental factors, making its assessment a complex systems problem in which indirect effects are significant in causality. Predictions were made by linking a tree growth simulation model, red spruce growth model (ARIM.SIM, to a GIS spatial model, red spruce habitat model (ARIM.HAB. ARIM.SIM quantifies direct and indirect interactions between red spruce and its growth factors, revealing the latter to be dominant. ARIM.HAB spatially distributes the ARIM.SIM simulations under the assumption that greater growth reflects higher probabilities of presence. ARIM.HAB predicts the future habitat suitability of red spruce based on growth predictions of ARIM.SIM under climate change and three air pollution scenarios: 10% increase, no change and 10% decrease. Results show that suitable habitats shrink most when air pollution increases. Higher temperatures cause losses of most low-elevation habitats. Increased precipitation and air pollution produce acid rain, which causes loss of both low- and high-elevation habitats. The general prediction is that climate change will cause contraction of red spruce habitats at both lower and higher elevations in GSMNP, and the effects will be exacerbated by increased air pollution. These predictions provide valuable information for understanding potential impacts of global climate change on the spatiotemporal distribution of red spruce habitats in GSMNP.

  13. Issues for resolving adverse effects on the safety culture of human work underload and workload transitions in complex human-machine systems

    International Nuclear Information System (INIS)

    Ryan, T.G.


    A workshop was conducted whose specific purpose was to build on earlier work of the US National Research Council, US federal government agencies, and the larger human factors community to: (1) clarify human factors issues pertaining to degraded safety performance in advanced human-machine systems(e.g., nuclear production, transportation, aerospace) due to human work underload and workload transition, and (2) develop strategies for resolving these issues. The workshop affirmed that: (1) work underload and workload transition are issues that will have to be addressed by designers of advanced human-machine systems, especially those relying on automation, if cost, performance, safety, and operator acceptability are to be optimized, (2) human machine allocation models, standards and guidelines which go beyond simple capability approaches will be needed to preclude or seriously diminish the work underload and workload transition problems, and (3) the 16 workload definition, measurement, situational awareness, and trust issues identified during the workshop, need resolution if these models, standards, and guidelines are to be achieved

  14. Toward Understanding Through Hermeneutic Letterwriting. (United States)

    Nyholm, Linda; Nyström, Lisbet; Lindström, Unni Å


    The authors present letterwriting as a hermeneutic research method in that it contributes to the methodological development within the hermeneutical research tradition in caring science. The hermeneutic methodology is inspired by Hans-Georg Gadamer. Hermeneutic letterwriting in accordance with Gadamer's thought is a form of dialogue in writing, where what is truthful about the thing itself is unveiled with the help of the language. Hermeneutic letterwriting is presented in five steps. As a method, hermeneutic letterwriting is appropriate for complex caring science issues, and it offers new opportunities for attaining a deeper understanding of the world of caring.

  15. Cultural Analysis - towards cross-cultural understanding

    DEFF Research Database (Denmark)

    Gullestrup, Hans

    The book considers intercultural understanding and co-action, partly by means of general insight into concept of culture and the dimensions which bring about cultural differences, and partly as a methodology to analyse a certain culture - whether one's own or others'. This leads towards...... an understanding of cultural complexity and cultural differences among people. Furthermore, the book provides a discussion of a number of ethical issues, which almost invariably will arise when people meet and co-act across cultural boundaries. Cultural Analysis consists of four parts. The first part offers...... a theoretical/abstract proposal for cultural understanding. The second part presents a theoretical/abstract proposal for under-standing intercultural plurality and complexity. The third part provides an empirical model for the analysis of intercultural co-action. Finally, the fourth part present and discusses...

  16. Teoria, determinação, complexidade: desafios da reflexão sobre educação Theory, determination, complexity: challenging issues in the reflection on education

    Directory of Open Access Journals (Sweden)

    Lílian do Valle


    answers, the old concepts, the logic and the explicative theories that fall under the weight of the everyday evidences of their exhaustion; on the other, the demand to mistrust all answers and the childish pleasure in deconstructing - how could we be surprised by the huge success being obtained by analyses that - under new clothing - offer to education the model of the natural world as a parameter and as a tool to help its understanding of the "human complexity"? How can we apprehend through our understanding something that, in its being, reveals its igneous character or, as it is usually said, its complexity? The present text looks at these issues and proposes, as a sort of challenge, that, in order to reflect upon the way of being that is peculiar to human beings, we should start with the human being him/herself.

  17. Performances on Rey Auditory Verbal Learning Test and Rey Complex Figure Test in a healthy, elderly Danish sample--reference data and validity issues

    DEFF Research Database (Denmark)

    Vogel, Asmus; Stokholm, Jette; Jørgensen, Kasper


    This study presents Danish data for Rey Auditory Verbal Learning Test (RAVLT) and Rey Complex Figure Test (RCFT) from 100 subjects aged 60-87 years. Education and estimated verbal intelligence (DART score) had a significant impact on the RAVLT trial 1-5 score but not on other RAVLT measures...

  18. Remote Sensing of Complex Flows by Doppler Wind Lidar: Summary of Issues and Preliminary Recommendations from IEA Wind Task 32 Phase 1

    Energy Technology Data Exchange (ETDEWEB)

    Clifton, Andrew


    IEA Wind Task 32 seeks to identify and mitigate the barriers to the adoption of lidar for wind energy applications. In Phase 1 of the task, a working group looked at the state of the art of wind lidar in complex flow conditions. This presentation is a short summary of that work, given at the start of Phase 2.

  19. Family Issues (United States)

    ... Information Publications Awards Partners Contact Us ¿Qué es Autismo? Donate Home What is Autism? What is Autism? ... Information Publications Awards Partners Contact Us ¿Qué es Autismo? Family Issues Home / Living with Autism / Family Issues ...

  20. Emotional Issues (United States)

    ... Home / Care for Duchenne / Emotional Issues Print Email Emotional Issues Duchenne’s emotional toll on a child can manifest in a ... important things you can provide to ensure the emotional health of your child. Parents of a child ...

  1. Issues in mounting randomized experiments in educational research ...

    African Journals Online (AJOL)

    As the field of education becomes increasingly complex and demanding, researchers more than ever before need to work at the frontiers of knowledge in order to understand the current global issues and problems of education. This calls for rigorous research whose findings are to inform government decision and policy.

  2. issues in mounting randomized experiments in educational research ...

    African Journals Online (AJOL)


    As the field of education becomes increasingly complex and demanding, researchers more than ever before need to work at the frontiers of knowledge in order to understand the current global issues and problems of education. This calls for rigorous research whose findings are to inform government decision and policy.

  3. Teaching for Diversity: Addressing Diversity Issues in Responsive ESL Instruction (United States)

    Fu, Jing


    Student diversity has become a typical phenomenon in American public schools. The impact of increasing diversity on literacy instruction is unchallenged. Teachers reinforce this message by often citing ESL student diversity as a barrier for literacy teaching. In order to better understand the complexity of diversity issues, I explored two ESL…

  4. Chernobyl, Three Mile Island and beyond: Lessons for Ontario? Current issue paper 117

    International Nuclear Information System (INIS)

    Yeager, K.L.


    This current issue paper reviews major accidents which have occurred at commercial and military nuclear facilities, and provides basic background on nuclear power and reactor design features to assist the novice in understanding the very complex technical issues surrounding these events. Above all, the role of human factors in the prevention of potential accident situations is emphasized. (author)

  5. In This Issue (United States)


    Advanced Instrumentation in the Educational Laboratory The instruments that chemists use in their research have changed dramatically in the past decades. The explosion in new techniques and their instrumental counterparts has been made possible by two significant advances. The rapid propagation of computer chips and circuitry provides opportunities to collect more specialized and refined data than ever before. Computer-controlled instruments can detect events that a human researcher would never perceive and can record hundreds of data points in the time that a person could only observe one or two. Coupled with these advances in technology are advances in theory that allow more sophisticated interpretation of data. A hundred years ago a sophisticated instrument was a balance that could weigh minute quantities. Today a sophisticated instrument is one that can identify the composition of that minute sample, determine its molecular weight, or reveal a great deal about its energy states and bonding. This bonanza of new instruments is wonderful for the research chemist but a curricular headache for the chemistry teacher. It takes more time to learn how to run an NMR than to use a balance, and more sophistication on the part of the student is needed to interpret the data. And yet many courses that only a generation ago sported an expensive analytical balance as its prize instrument now require students to understand and operate a whole panoply of complex tools. Teachers faced with accommodating these curricular changes will find several articles in this issue helpful--either providing information on new techniques or descriptions of how to incorporate them into the classroom. Electrospray ionization mass spectrometry is one of the newest tools that has been added to the analytical arsenal. It is an extension of mass spectrometry that overcomes the old barrier that allowed only analysis of low molecular weight, volatile compounds. It is now possible to use MS for

  6. Understanding the Electronic Structure of 4d Metal Complexes: From Molecular Spinors to L-Edge Spectra of a di-Ru Catalyst

    Energy Technology Data Exchange (ETDEWEB)

    Alperovich, Igor; Smolentsev, Grigory; Moonshiram, Dooshaye; Jurss, Jonah W.; Concepcion, Javier J.; Meyer, Thomas J.; Soldatov, Alexander; Pushkar, Yulia (UNC); (Purdue); (SFU-Russia); (Lund)


    L{sub 2,3}-edge X-ray absorption spectroscopy (XAS) has demonstrated unique capabilities for the analysis of the electronic structure of di-Ru complexes such as the blue dimer cis,cis-[Ru{sub 2}{sup III}O(H{sub 2}O){sub 2}(bpy){sub 4}]{sup 4+} water oxidation catalyst. Spectra of the blue dimer and the monomeric [Ru(NH{sub 3}){sub 6}]{sup 3+} model complex show considerably different splitting of the Ru L{sub 2,3} absorption edge, which reflects changes in the relative energies of the Ru 4d orbitals caused by hybridization with a bridging ligand and spin-orbit coupling effects. To aid the interpretation of spectroscopic data, we developed a new approach, which computes L{sub 2,3}-edges XAS spectra as dipole transitions between molecular spinors of 4d transition metal complexes. This allows for careful inclusion of the spin-orbit coupling effects and the hybridization of the Ru 4d and ligand orbitals. The obtained theoretical Ru L{sub 2,3}-edge spectra are in close agreement with experiment. Critically, existing single-electron methods (FEFF, FDMNES) broadly used to simulate XAS could not reproduce the experimental Ru L-edge spectra for the [Ru(NH{sub 3}){sub 6}]{sup 3+} model complex nor for the blue dimer, while charge transfer multiplet (CTM) calculations were not applicable due to the complexity and low symmetry of the blue dimer water oxidation catalyst. We demonstrated that L-edge spectroscopy is informative for analysis of bridging metal complexes. The developed computational approach enhances L-edge spectroscopy as a tool for analysis of the electronic structures of complexes, materials, catalysts, and reactive intermediates with 4d transition metals.

  7. Understanding the Data Complexity continuum to reduce data management costs and increase data usability through partnerships with the National Centers for Environmental Information (United States)

    Mesick, S.; Weathers, K. W.


    Data complexity can be seen as a continuum from complex to simple. The term data complexity refers to data collections that are disorganized, poorly documented, and generally do not follow best data management practices. Complex data collections are challenging and expensive to manage. Simplified collections readily support automated archival processes, enhanced discovery and data access, as well as production of services that make data easier to reuse. In this session, NOAA NCEI scientific data stewards will discuss the data complexity continuum. This talk will explore data simplification concepts, methods, and tools that data managers can employ which may offer more control over data management costs and processes, while achieving policy goals for open data access and ready reuse. Topics will include guidance for data managers on best allocation of limited data management resources; models for partnering with NCEI to accomplish shared data management goals; and will demonstrate through case studies the benefits of investing in documentation, accessibility, and services to increase data value and return on investment.

  8. An Integrated Academic Literacy Approach to Improving Students' Understanding of Plagiarism in an Accounting Course (United States)

    Powell, Lisa; Singh, Nishani


    Plagiarism in higher education is a widespread and complex issue. Students' understanding of plagiarism differs as a result of combining their prior learning about referencing with their current experience of institutional policies and generic resources. Plagiarism was identified as a major learning issue in a core second-year undergraduate…

  9. Bite-angle bending as a key for understanding group-10 metal reactivity of d(10)-[M(NHC)(2)] complexes with sterically modest NHC ligands

    NARCIS (Netherlands)

    Hering, Florian; Nitsch, Joern; Paul, Ursula; Steffen, Andreas; Bickelhaupt, F. Matthias; Radius, Udo


    Synthesis, characterization and investigations on the reactivity of the novel metal basic, yet isolable 14 VE NHC-complexes [M0(iPr2Im)2] (M = Pd 3, Pt 4; iPr2Im = 1,3-di-isopropyl-imidazolin-2-ylidene; VE = valence electron; NHC = N-heterocyclic carbene) is reported and compared to the chemistry of

  10. The quantum oscillator on complex projective space (Lobachewski space) in a constant magnetic field and the issue of generic boundary conditions

    International Nuclear Information System (INIS)

    Giri, Pulak Ranjan


    We perform a one-parameter family of self-adjoint extensions characterized by the parameter ω 0 . This allows us to get generic boundary conditions for the quantum oscillator on N-dimensional complex projective space (CP N ) and on its non-compact version, i.e., Lobachewski space (L N ) in the presence of a constant magnetic field. As a result, we get a family of energy spectra for the oscillator. In our formulation the already known result of this oscillator also belongs to the family. We have also obtained an energy spectrum which preserves all the symmetries (full-hidden symmetry and rotational symmetry) of the oscillator. The method of self-adjoint extensions has also been discussed for a conic oscillator in the presence of the constant magnetic field

  11. Plant-beneficial elements status assessment in soil-plant system in the vicinity of a chemical industry complex: shedding light on forage grass safety issues. (United States)

    Anjum, Naser A; Duarte, Armando C; Pereira, Eduarda; Ahmad, Iqbal


    Human health is closely linked with soils via plants, grazers, or plant-based products. This study estimated plant-beneficial elements (macronutrients: K, P; secondary macronutrients: Ca, Mg; micronutrients: Mo, Mn, Na, Ni, Se) in both soils and shoots of two forage grass species (Eriophorum angustifolium and Lolium perenne) prevalent in the vicinity of a chemical industry complex (Estarreja, Portugal). Both soils and plants from the chemical industrial areas exhibited differential concentrations of the studied elements. In soils, the role of contamination was evidenced as insignificant in context of its impact on all the tested macro and secondary macronutrients except P, and micronutrients such as Mo and Ni. In forage grass plant shoots, the role of contamination was evidenced as insignificant in relation to its impact on all the tested macro and secondary macronutrients except K. Between the two forage grass plants, high Se-harboring L. perenne cannot be recommended for its use as animal feed.

  12. Using ILD or ITD Cues for Sound Source Localization and Speech Understanding in a Complex Listening Environment by Listeners with Bilateral and with Hearing-Preservation Cochlear Implants (United States)

    Loiselle, Louise H.; Dorman, Michael F.; Yost, William A.; Cook, Sarah J.; Gifford, Rene H.


    Purpose: To assess the role of interaural time differences and interaural level differences in (a) sound-source localization, and (b) speech understanding in a cocktail party listening environment for listeners with bilateral cochlear implants (CIs) and for listeners with hearing-preservation CIs. Methods: Eleven bilateral listeners with MED-EL…

  13. Ask, don’t tell : A complex dynamic systems approach to improving science education by focusing on the co-construction of scientific understanding

    NARCIS (Netherlands)

    van Vondel, Sabine; Steenbeek, Henderien; van Dijk, Marijn; van Geert, Paul

    Studying real-time teacher-student interaction provides insight into student's learning processes. In this study, upper grade elementary teachers were supported to optimize their instructional skills required for co-constructing scientific understanding. First, we examined the effect of the Video

  14. The Frankenstein Complex

    DEFF Research Database (Denmark)

    Jensen, Boris Brorman


    In his polemic essay Boris Brorman Jensen raises the issue of a perceived academic reluctance to acknowledge the impact of real-world pragmatics on the architectural expression of built architecture. “One might claim that parts of architectural academia suffer from a Frankenstein complex that see...... to understand and engage the full range of technical skills present in the interdisciplinary team of consultants......., of our given lifeworld.” Being the first major project of the emerging practice Element Architects, the Teachers’ Union Conference Center highlights the importance of the architect as a skilled negotiator, not merely the provider of flattering design. Critically acclaimed for its unconventional approach...

  15. Complexity, cognition and the city

    CERN Document Server

    Portugali, Juval


    Complexity, Cognition and the City aims at a deeper understanding of urbanism, while invoking, on an equal footing, the contributions both the hard and soft sciences have made, and are still making, when grappling with the many issues and facets of regional planning and dynamics. In this work, the author goes beyond merely seeing the city as a self-organized, emerging pattern of some collective interaction between many stylized urban "agents" – he makes the crucial step of attributing cognition to his agents and thus raises, for the first time, the question on how to deal with a complex system composed of many interacting complex agents in clearly defined settings. Accordingly, the author eventually addresses issues of practical relevance for urban planners and decision makers. The book unfolds its message in a largely nontechnical manner, so as to provide a broad interdisciplinary readership with insights, ideas, and other stimuli to encourage further research – with the twofold aim of further pushing ba...

  16. Remedial action of matrices contaminated by cobalt with supercritical CO2: contribution to the understanding of the complex formation mechanisms and to the diphasic transfers

    International Nuclear Information System (INIS)

    Gervais, Florence


    Soils rehabilitation using supercritical CO 2 seems an interesting alternative way to existing techniques. No effluents are generated during the supercritical fluid extraction, which is the main advantage of this process. In order to be extracted by this techniques, metals or radionuclides have to be complexed by suitable chelating agents. Beta-diketones and dithiocarbamates (fluorinated or not) have been chosen. The first part of this work deals with chemical equilibria mechanisms study in an aqueous phase. Experiments show a very weak cobalt complexation kinetics with acetylacetone. Moreover, this complex exhibit a hydrophilic behaviour. On the other hand, cobalt and dithiocarbamate instantaneously from a chelate which is very hydrophobic. Mass transfer between extracting and aqueous phases (hexane and SC CO 2 ) are also investigated. Supercritical CO 2 seems to have a greater affinity towards fluorinated beta-diketones than hexane. This tendency is confirmed by in situ commercial chelates (fluorinates or not) solubility measurements using X-ray absorption spectroscopy. However, cobalt-beta-diketonates are hydrophilic because of their partial hydration. This kind of chelating agents is not suitable to cobalt supercritical fluid extraction from an aqueous phase. Inversely, distribution coefficients of hydrophobic dithiocarbamates are higher than beta-diketonates, whatever the extracting solvent is. Metals extraction from an aqueous matrix seems possible with these chelating agents. (author) [fr

  17. Stability constants important to the understanding of plutonium in environmental waters, hydroxy and carbonate complexation of PuO2+

    Energy Technology Data Exchange (ETDEWEB)

    Bennett, Dianne Angelo [Univ. of California, Berkeley, CA (United States)


    The formation constants for the reactions PuO2+ + H2O = PuO2(OH) + H+ and PuO2+ + CO32- = PuO2(CO3)- were determined in aqueous sodium perchlorate solutions by laser-induced photoacoustic spectroscopy. The molar absorptivity of the PuO2+ band at 569 nm decreased with increasing hydroxide concentration. Similarly, spectral changes occurred between 540 and 580 nm as the carbonate concentration was increased. The absorption data were analyzed by the non-linear least-squares program SQUAD to yield complexation constants. Using the specific ion interaction theory, both complexation constants were extrapolated to zero ionic strength. These thermodynamic complexation constants were combined with the oxidation-reduction potentials of Pu to obtain Eh versus pH diagrams.

  18. Joining the dots - understanding the complex interplay between the values we place on wildlife, biodiversity conservation, human and animal health: A review. (United States)

    Ryser-Degiorgis, M-P; Pewsner, M; Angst, C


    The value of wildlife has long been ignored or under-rated. However, growing concerns about biodiversity loss and emerging diseases of wildlife origin have enhanced debates about the importance of wildlife. Wildlife-related diseases are viewed through these debates as a potential threat to wildlife conservation and domestic animal and human health. This article provides an overview of the values we place on wildlife (positive: socio-cultural, nutritional, economic, ecological; and negative: damages, health issues) and of the significance of diseases for biodiversity conservation. It shows that the values of wildlife, the emergence of wildlife diseases and biodiversity conservation are closely linked. The article also illustrates why investigations into wildlife diseases are now recognized as an integral part of global health issues. The modern One Health concept requires multi-disciplinary research groups including veterinarians, human physicians, ecologists and other scientists collaborating towards a common goal: prevention of disease emergence and preservation of ecosystems, both of which are essential to protect human life and well-being.

  19. Theatre pedagogy as an area of negotiating and understanding complex concepts by kindergartners in times of crisis: an intervention-based research study


    Giotaki, Marianna; Lenakakis, Antonis


    In this research theatre pedagogy was used to explore kindergartners’ perceptions of the economic crisis and its aspects in their everyday lives, as well as to provide them with opportunities to invest crisis situations with a positive, dynamic meaning, and to shift towards the humanitarian values of justice, active citizenship and understanding the other. Through our theatre-pedagogic programme, a social topic was put forward to the class, and performing arts tools were used to generate a fr...

  20. Hunger and Development [Issue Packet]. (United States)

    American Freedom from Hunger Foundation, Washington, DC.

    A variety of informational materials is compiled in this issue packet concentrating on hunger and development. They have been assembled to understand the issues associated with the facts of world hunger and to try to invent new forms of action and thought necessary to find the possibilities hidden in the hunger issue. Items include: (1) a fact and…

  1. Understanding implementation and change in complex interventions. From single- to multi-methodological research on the promotion of youths’ participation in physical education

    DEFF Research Database (Denmark)

    Agergaard, Sine; Dankers, Silke; Munk, Mette


    Existing studies on complex interventions aiming to promote youths’ participation in physical education (PE) appear to be predominantly single-methodological. The aim of this article is to examine the benefits and challenges of evaluating an intervention to increase youths’ participation...... and experiences of social inclusion in the PE context using a multi-method approach integrating quantitative and qualitative approaches. The multi-method approach allowed an integration of the findings with regard to the implementation as well as the effect of the intervention. First of all, standardized...

  2. A complexity basis for phenomenology: How information states at criticality offer a new approach to understanding experience of self, being and time. (United States)

    Hankey, Alex


    In the late 19th century Husserl studied our internal sense of time passing, maintaining that its deep connections into experience represent prima facie evidence for it as the basis for all investigations in the sciences: Phenomenology was born. Merleau-Ponty focused on perception pointing out that any theory of experience must accord with established aspects of biology i.e. be embodied. Recent analyses suggest that theories of experience require non-reductive, integrative information, together with a specific property connecting them to experience. Here we elucidate a new class of information states with just such properties found at the loci of control of complex biological systems, including nervous systems. Complexity biology concerns states satisfying self-organized criticality. Such states are located at critical instabilities, commonly observed in biological systems, and thought to maximize information diversity and processing, and hence to optimize regulation. Major results for biology follow: why organisms have unusually low entropies; and why they are not merely mechanical. Criticality states form singular self-observing systems, which reduce wave packets by processes of perfect self-observation associated with feedback gain g = 1. Analysis of their information properties leads to identification of a new kind of information state with high levels of internal coherence, and feedback loops integrated into their structure. The major idea presented here is that the integrated feedback loops are responsible for our 'sense of self', and also the feeling of continuity in our sense of time passing. Long-range internal correlations guarantee a unique kind of non-reductive, integrative information structure enabling such states to naturally support phenomenal experience. Being founded in complexity biology, they are 'embodied'; they also fulfill the statement that 'The self is a process', a singular process. High internal correlations and René Thom

  3. Sixth-Grade Students' Progress in Understanding the Mechanisms of Global Climate Change (United States)

    Visintainer, Tammie; Linn, Marcia


    Developing solutions for complex issues such as global climate change requires an understanding of the mechanisms involved. This study reports on the impact of a technology-enhanced unit designed to improve understanding of global climate change, its mechanisms, and their relationship to everyday energy use. Global Climate Change, implemented in…

  4. Nonhuman primate models for cell-associated simian immunodeficiency virus transmission: the need to better understand the complexity of HIV mucosal transmission. (United States)

    Bernard-Stoecklin, Sibylle; Gommet, Céline; Cavarelli, Mariangela; Le Grand, Roger


    Nonhuman primates are extensively used to assess strategies to prevent infection from sexual exposure to human immunodeficiency virus (HIV) and to study mechanisms of mucosal transmission. However, although semen represents one of the most important vehicles for the virus, the vast majority of preclinical challenge studies have used cell-free simian immunodeficiency virus (SIV) or simian/human immunodeficiency virus (SHIV) viral particles inoculated as diluted culture supernatants. Semen is a complex body fluid containing many factors that may facilitate or decrease HIV infectiousness. The virus in semen is present in different forms: as free virus particles or as cell-associated virus (ie, within infected leukocytes). Although cell-to-cell transmission of HIV is highly efficient, the role of cell-associated virus in semen has been surprisingly poorly investigated in nonhuman primate models. Mucosal exposure of macaques to cell-associated SIV by using infected peripheral blood mononuclear cells or spleen cells has been shown to be an efficient means of infection; however, it has yet to be shown that SIV- or SHIV-infected seminal leukocytes can transmit infection in vivo. Improvement of animal models to better recapitulate the complex microenvironment at portals of HIV entry is needed for testing candidate antiretrovirals, microbicides, and vaccines. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail:

  5. Research Article Special Issue

    African Journals Online (AJOL)



    Oct 17, 2017 ... modelling complex problems, especially like healthcare sector [12], 2) distributed and concurrent system [13], 3) divide and conquer concept that facilitates scalability and reutilization [11] and 4) has the ability to solve a privacy issue of data sharing in the healthcare sector [14]. Therefore, in this paper, we ...

  6. Complexity and formative experiences

    Directory of Open Access Journals (Sweden)

    Roque Strieder


    Full Text Available The contemporaneity is characterized by instability and diversity calling into question certainties and truths proposed in modernity. We recognize that the reality of things and phenomena become effective as a set of events, interactions, retroactions and chances. This different frame extends the need for revision of the epistemological foundations that sustain educational practices and give them sense. The complex thinking is an alternative option for acting as a counterpoint to classical science and its reductionist logic and knowledge compartmentalization, as well as to answer to contemporary epistemological and educational challenges. It aims to associate different areas and forms of knowledge, without, however merge them, distinguishing without separating the several disciplines and instances of the realities. This study, in theoretical references, highlights the relevance of complex approaches to support formative experiences because also able to produce complexities in reflections about educational issues. We conclude that formative possibilities from complexity potentialize the resignification of human’s conception and the understanding of its singularity in interdependence; The understanding that pedagogical and educational activities is a constant interrogation about the possibilities of knowing the knowledge and reframe learning, far beyond knowing its functions and utilitarian purposes; and, as a formative possibility, places us on the trail of responsibility, not as something eventual, but present and indicative of freedom to choose to stay or go beyond.

  7. Understanding the Hydro-metathesis Reaction of 1-decene by Using Well-defined Silica Supported W, Mo, Ta Carbene/Carbyne Complexes

    KAUST Repository

    Saidi, Aya


    Direct conversion of 1-decene to petroleum range alkanes was obtained using hydro-metathesis reaction. To understand this reaction we employed three different well-defined single site catalysts precursors; [(≡Si-O-)W(CH3)5] 1, [(≡Si-O-)Mo(≡CtBu)(CH2tBu)2] 2 and [(≡Si-O)Ta(=CHtBu)(CH2tBu)2] 3. We witnessed that in our conditions olefin metathesis/isomerization of 1-decene occurs much faster followed by reduction of the newly formed olefins rather than reduction of the 1-decene to decane, followed by metathesis of decane. We found that Mo-based catalyst favors 2+2 cycloaddition of 1-decene forming metallocarbene, followed by reduction of the newly formed olefins to alkanes. However, in the case of W and Ta-based catalysts, a rapid isomerization (migration) of the double bond followed by olefin metathesis and reduction of the newly formed olefins were observed. We witnessed that silica supported W catalyst precursor 1 and Mo catalyst precursor 2 are better catalysts for hydro-metathesis reaction with TONs of 818 and 808 than Ta-based catalyst 3 (TON of 334). This comparison of the catalysts provides us a better understanding that, if a catalyst is efficient in olefin metathesis reaction it would be a better catalyst for hydro-metathesis reaction.

  8. Synthesis, Crystal Structures, Magnetic Properties, and Theoretical Investigation of a New Series of NiII-LnIII-WVHeterotrimetallics: Understanding the SMM Behavior of Mixed Polynuclear Complexes. (United States)

    Vieru, Veacheslav; Pasatoiu, Traian D; Ungur, Liviu; Suturina, Elizaveta; Madalan, Augustin M; Duhayon, Carine; Sutter, Jean-Pascal; Andruh, Marius; Chibotaru, Liviu F


    The polynuclear compounds containing anisotropic metal ions often exhibit efficient barriers for blocking of magnetization at fairly arbitrary geometries. However, at variance with mononuclear complexes, which usually become single-molecule magnets (SMM) under the sole requirement of a highly axial crystal field at the metal ion, the factors influencing the SMM behavior in polynuclear complexes, especially, with weakly axial magnetic ions, still remain largely unrevealed. As an attempt to clarify these conditions, we present here the synthesis, crystal structures, magnetic behavior, and ab initio calculations for a new series of Ni II -Ln III -W V trimetallics, [(CN) 7 W(CN)Ni(H 2 O)(valpn)Ln(H 2 O) 4 ]·H 2 O (Ln = Y 1, Eu 2, Gd 3, Tb 4, Dy 5, Lu 6). The surprising finding is the absence of the magnetic blockage even for compounds involving strongly anisotropic Dy III and Tb III metal ions. This is well explained by ab initio calculations showing relatively large transversal components of the g-tensor in the ground exchange Kramers doublets of 1 and 4 and large intrinsic tunneling gaps in the ground exchange doublets of 3 and 5. In order to get more insight into this behavior, another series of earlier reported compounds with the same trinuclear [W V Ni II Ln III ] core structure, [(CN) 7 W(CN)Ni(dmf)(valdmpn)Ln(dmf) 4 ]·H 2 O (Ln = Gd III 7, Tb III 8a, Dy III 9, Ho III 10), [(CN) 7 W(CN)Ni(H 2 O)(valdmpn)Tb(dmf) 2.5 (H 2 O) 1.5 ]·H 2 O·0.5dmf 8b, and [(CN) 7 W(CN)Ni(H 2 O)(valdmpn)Er(dmf) 3 (H 2 O) 1 ]·H 2 O·0.5dmf 11, has been also investigated theoretically. In this series, only 8b exhibits SMM behavior which is confirmed by the present ab initio calculations. An important feature for the entire series is the strong ferromagnetic coupling between Ni(II) and W(V), which is due to an almost perfect trigonal dodecahedron geometry of the octacyano wolframate fragment. The reason why only 8b is an SMM is explained by positive zero-field splitting on the nickel

  9. Special Issue Editorial

    African Journals Online (AJOL)

    broadened understanding of safety and implications for violence prevention on campus. The issue of exclusionary violence and bullying on the school playground is addressed by Emmanuel Mayeza in the following paper. Mayeza asks about the construction and policing of gender on the school playground, specifically in ...

  10. Inflation. National Issues Forum. (United States)

    Public Agenda Foundation, New York, NY.

    This booklet is designed to help citizens understand public issues concerning chronic inflation and to work toward acceptable solutions for ending inflation. There are seven chapters. Chapter one provides a brief explanation of the nation's inflation problem. The psychological, social, and economic impact of inflation is the topic of chapter two.…

  11. Understanding the visual resource (United States)

    Floyd L. Newby


    Understanding our visual resources involves a complex interweaving of motivation and cognitive recesses; but, more important, it requires that we understand and can identify those characteristics of a landscape that influence the image formation process. From research conducted in Florida, three major variables were identified that appear to have significant effect...

  12. The `What is a system' reflection interview as a knowledge integration activity for high school students' understanding of complex systems in human biology (United States)

    Tripto, Jaklin; Ben-Zvi Assaraf, Orit; Snapir, Zohar; Amit, Miriam


    This study examined the reflection interview as a tool for assessing and facilitating the use of 'systems language' amongst 11th grade students who have recently completed their first year of high school biology. Eighty-three students composed two concept maps in the 10th grade-one at the beginning of the school year and one at its end. The first part of the interview is dedicated to guiding the students through comparing their two concept maps and by means of both explicit and non-explicit teaching. Our study showed that the explicit guidance in comparing the two concept maps was more effective than the non-explicit, eliciting a variety of different, more specific, types of interactions and patterns (e.g. 'hierarchy', 'dynamism', 'homeostasis') in the students' descriptions of the human body system. The reflection interview as a knowledge integration activity was found to be an effective tool for assessing the subjects' conceptual models of 'system complexity', and for identifying those aspects of a system that are most commonly misunderstood.


    Directory of Open Access Journals (Sweden)

    Graham Brewer


    Full Text Available The literature is replete with accounts of the struggle to effectively target and deploy postdisaster aid so as to achieve maximum benefit to recipients, both direct and indirect, over the short- and longer-term. Generally these stories balance success with lessons learned from failure, in order to inform practice in future recovery and reconstruction events. They are often derived from the heroic accounts of key actors in case studies, on the understandable basis that these carefully selected individuals will have been pivotal in designing and directing the implementation of aid programmes. The influence of non-humans such as organisations, systems, processes, or elements of the constructed environment are considered only insofar as they impact upon the experiences of the raconteurs. However actor network theory, a technique originally developed to examine phenomena at the sociotechnological interface, ascribes human characteristics such as motives and behaviours equally to human and non-human actants, ultimately to better explain the worldly consequences of their interaction. This paper reports on the ex post application of ANT to data collected in an earlier actor-centric study, to both evaluate its usefulness in disaster research and to identify potential gaps in the disaster research agenda.

  14. Commentary: An exemplar of progress in understanding complex disorders - reflections on what we have learned about eating disorders (Culbert et al., 2015). (United States)

    Smith, Gregory T; Davis, Heather A


    A number of recent advances in eating disorders research have helped clarify the nature of risk for the development of such disorders. Culbert et al. () provide an empirical and thoughtful review of these recent advances. The authors identified empirically established risk factors in each of several categories of risk for eating disorders: genetic influences, neurotransmitter activity, hormones, personality, and sociocultural influences. We highlight three implications of their review. First, the review can serve as an important asset to eating disorder researchers, both substantively, by providing a comprehensive account of empirically supported risk processes; and methodologically, by highlighting good standards of evidence for acceptance of a candidate risk factor. Second, eating disorder risk is increased by both transdiagnostic and eating disorder-specific factors; there is a need to understand how these types of factors transact with each other. Third and most important, we highlight the importance of Culbert et al.'s advocacy for the development of theoretical models, and empirical tests of those models that specify transactions among different types of risk factors, such as those based on genetic, neurobiological, personality, and social processes. © 2015 Association for Child and Adolescent Mental Health.

  15. Mouse Models of Genomic Syndromes as Tools for Understanding the Basis of Complex Traits: An Example with the Smith-Magenis and the Potocki-Lupski Syndromes (United States)

    Carmona-Mora, P; Molina, J; Encina, C.A; Walz, K


    Each human's genome is distinguished by extra and missing DNA that can be “benign” or powerfully impact everything from development to disease. In the case of genomic disorders DNA rearrangements, such as deletions or duplications, correlate with a clinical specific phenotype. The clinical presentations of genomic disorders were thought to result from altered gene copy number of physically linked dosage sensitive genes. Genomic disorders are frequent diseases (~1 per 1,000 births). Smith-Magenis syndrome (SMS) and Potocki-Lupski syndrome (PTLS) are genomic disorders, associated with a deletion and a duplication, of 3.7 Mb respectively, within chromosome 17 band p11.2. This region includes 23 genes. Both syndromes have complex and distinctive phenotypes including multiple congenital and neurobehavioral abnormalities. Human chromosome 17p11.2 is syntenic to the 32-34 cM region of murine chromosome 11. The number and order of the genes are highly conserved. In this review, we will exemplify how genomic disorders can be modeled in mice and the advantages that such models can give in the study of genomic disorders in particular and gene copy number variation (CNV) in general. The contributions of the SMS and PTLS animal models in several aspects ranging from more specific ones, as the definition of the clinical aspects of the human clinical spectrum, the identification of dosage sensitive genes related to the human syndromes, to the more general contributions as the definition of genetic locus impacting obesity and behavior and the elucidation of general mechanisms related to the pathogenesis of gene CNV are discussed. PMID:19949547

  16. Local modelling techniques for assessing micro-level impacts of risk factors in complex data: understanding health and socioeconomic inequalities in childhood educational attainments. (United States)

    Zhou, Shang-Ming; Lyons, Ronan A; Bodger, Owen G; John, Ann; Brunt, Huw; Jones, Kerina; Gravenor, Mike B; Brophy, Sinead


    Although inequalities in health and socioeconomic status have an important influence on childhood educational performance, the interactions between these multiple factors relating to variation in educational outcomes at micro-level is unknown, and how to evaluate the many possible interactions of these factors is not well established. This paper aims to examine multi-dimensional deprivation factors and their impact on childhood educational outcomes at micro-level, focusing on geographic areas having widely different disparity patterns, in which each area is characterised by six deprivation domains (Income, Health, Geographical Access to Services, Housing, Physical Environment, and Community Safety). Traditional health statistical studies tend to use one global model to describe the whole population for macro-analysis. In this paper, we combine linked educational and deprivation data across small areas (median population of 1500), then use a local modelling technique, the Takagi-Sugeno fuzzy system, to predict area educational outcomes at ages 7 and 11. We define two new metrics, "Micro-impact of Domain" and "Contribution of Domain", to quantify the variations of local impacts of multidimensional factors on educational outcomes across small areas. The two metrics highlight differing priorities. Our study reveals complex multi-way interactions between the deprivation domains, which could not be provided by traditional health statistical methods based on single global model. We demonstrate that although Income has an expected central role, all domains contribute, and in some areas Health, Environment, Access to Services, Housing and Community Safety each could be the dominant factor. Thus the relative importance of health and socioeconomic factors varies considerably for different areas, depending on the levels of each of the other factors, and therefore each component of deprivation must be considered as part of a wider system. Childhood educational achievement could

  17. Sanskrit Issue. (United States)

    Miller, Barbara Stoler, Ed.


    This issue of "Mahfil" is devoted to Sanskrit literature and contains a note on Sanskrit pronunciation and selections of Sanskrit literature. It also contains articles analyzing and discussing various aspects of the literature, including "Sanskrit Rhetoric and Poetic,""The Creative Role of the Goddess Vac in the…

  18. Optimization Issues with Complex Rotorcraft Comprehensive Analysis (United States)

    Walsh, Joanne L.; Young, Katherine C.; Tarzanin, Frank J.; Hirsh, Joel E.; Young, Darrell K.


    This paper investigates the use of the general purpose automatic differentiation (AD) tool called Automatic Differentiation of FORTRAN (ADIFOR) as a means of generating sensitivity derivatives for use in Boeing Helicopter's proprietary comprehensive rotor analysis code (VII). ADIFOR transforms an existing computer program into a new program that performs a sensitivity analysis in addition to the original analysis. In this study both the pros (exact derivatives, no step-size problems) and cons (more CPU, more memory) of ADIFOR are discussed. The size (based on the number of lines) of the VII code after ADIFOR processing increased by 70 percent and resulted in substantial computer memory requirements at execution. The ADIFOR derivatives took about 75 percent longer to compute than the finite-difference derivatives. However, the ADIFOR derivatives are exact and are not functions of step-size. The VII sensitivity derivatives generated by ADIFOR are compared with finite-difference derivatives. The ADIFOR and finite-difference derivatives are used in three optimization schemes to solve a low vibration rotor design problem.

  19. Understanding the complexity of the Lévy-walk nature of human mobility with a multi-scale cost∕benefit model. (United States)

    Scafetta, Nicola


    human mobility, that the proposed model predicts the statistical properties of human mobility below 1 km ranges, where people just walk. In the latter case, the threshold between zone 1 and zone 2 may be around 100-200 m and, perhaps, may have been evolutionary determined by the natural human high resolution visual range, which characterizes an area of interest where the benefits are assumed to be randomly and uniformly distributed. This rich and suggestive interpretation of human mobility may characterize other complex random walk phenomena that may also be described by a N-piece fit Pareto distributions with increasing integer exponents. This study also suggests that distribution functions used to fit experimental probability distributions must be carefully chosen for not improperly obscuring the physics underlying a phenomenon.

  20. Understanding the complexity of the Lévy-walk nature of human mobility with a multi-scale cost/benefit model (United States)

    Scafetta, Nicola


    mobility, that the proposed model predicts the statistical properties of human mobility below 1 km ranges, where people just walk. In the latter case, the threshold between zone 1 and zone 2 may be around 100-200 m and, perhaps, may have been evolutionary determined by the natural human high resolution visual range, which characterizes an area of interest where the benefits are assumed to be randomly and uniformly distributed. This rich and suggestive interpretation of human mobility may characterize other complex random walk phenomena that may also be described by a N-piece fit Pareto distributions with increasing integer exponents. This study also suggests that distribution functions used to fit experimental probability distributions must be carefully chosen for not improperly obscuring the physics underlying a phenomenon.

  1. Understanding Carbohydrates (United States)

    ... Size: A A A Listen En Español Understanding Carbohydrates How much and what type of carbohydrate foods ... glucose levels in your target range. Explore: Understanding Carbohydrates Glycemic Index and Diabetes Learn about the glycemic ...

  2. Communication dated 27 August 2007 from the Permanent Mission of the Islamic Republic of Iran to the Agency concerning the text of the 'Understandings of the Islamic Republic of Iran and the IAEA on the Modalities of Resolution of the Outstanding Issues'

    International Nuclear Information System (INIS)


    The Secretariat has received a Note Verbale dated 27 August 2007 from the Permanent Mission of the Islamic Republic of Iran, attaching the text of the 'Understandings of the Islamic Republic of Iran and the IAEA on the Modalities of Resolution of the Outstanding Issues'. The Note Verbale and, as requested therein, the attached document are herewith attached for information

  3. Environmental Issues are Controversial Issues. (United States)

    Hepburn, Mary Allaire

    The extensive social-scientific interest and continuing relevance of environmental study assure its immediate and long-range importance in the social studies. But the crisis atmosphere surrounding this issue threatens a thoughtful, systematic approach to the subject, and poses the danger of a careless rush to activity. As social studies educators,…

  4. Transmission issues

    International Nuclear Information System (INIS)

    Bradford, J.; Wilson, L.; Thon, S.; Millar, N.


    This session on transmission issues focused on the role that transmission plays in electricity markets and the importance of getting the market structure right in terms of generation divestiture with buy back contracts, demand side responsive programs, transmission upgrades and long term contracts. The difficulties of distinguishing between market power and scarcity were examined along with some of the complications that ensue if transmission experiences congestion, as exemplified by the August 2003 blackout in eastern North America. The presentations described the best ways to handle transmission issues, and debated whether transmission should be deregulated or follow market forces. Issues of interconnections and reliability of connections were also debated along with the attempt to integrate renewables into the grid. Some presentations identified what new transmission must be built and what must be done to ensure that transmission gets built. The challenges and business opportunities for transmission in Alberta were discussed with reference to plans to invest in new infrastructure, where it is going outside of the province and how it works with other jurisdictions. Manitoba's Conawapa Hydro Project and its 2000 MW tie line to Ontario was also discussed. Some examples of non-optimal use of interconnections in Europe were also discussed in an effort to learn from these mistakes and avoid them in Canada. tabs., figs

  5. Miscellaneous issues

    International Nuclear Information System (INIS)


    The New Brunswick Market Design Committee has examined several issues regarding the restructuring of the province's electricity sector. This report presents issues that require guidance for implementation, with particular focus on options available for their resolutions. The issues include: (1) rate principles for stranded offer service (SOS) supply, (2) the ability of contestable customers to return to SOS after having left it, (3) whether loads embedded in distribution systems are eligible to participate in the bilateral contract market, (4) whether generators or suppliers can offer capacity and energy to SOS suppliers in competition with the SOS supplier, and (5) details for the balancing market, including pricing, bidding protocols, settlements and how intermittent power sources can participate in the market. A section on pricing for SOS explains pricing principles, the use of export profits, pricing for SOS capacity, and time of use pricing. The Committee has made recommendations for the electricity system in the province to have an energy imbalance service that can move towards a market in order to develop an efficient and effective service. This report also explains pricing in the balancing market, penalties, and settlements. 7 refs

  6. Complex variables

    CERN Document Server

    Fisher, Stephen D


    The most important topics in the theory and application of complex variables receive a thorough, coherent treatment in this introductory text. Intended for undergraduates or graduate students in science, mathematics, and engineering, this volume features hundreds of solved examples, exercises, and applications designed to foster a complete understanding of complex variables as well as an appreciation of their mathematical beauty and elegance. Prerequisites are minimal; a three-semester course in calculus will suffice to prepare students for discussions of these topics: the complex plane, basic

  7. Understanding complex structures in fold-and-thrust belts. Integration of geometric and growth strata analyses, paleomagnetism, AMS and analogue models in the Western termination of the Southern Pyrenees (United States)

    Pueyo, Emilio L.; Sánchez, Elisa; Oliva-Urcia, Belén; José Ramón, Ma


    Classic 2D approaches have helped the understanding of the geometry and kinematics of fold-and-thrust belts belts (FAT belts) but are insufficient to unravel many natural cases. This is because deformation is 3D from the geometric point of view and, thus, cylindrical features may be considered as a simplification. On the other hand, deformation kinematics is usually complex, diachronic and poliphasic in real cases. Therefore, FAT belts have to be always considered in 4D. In this sense, the Southern Pyrenees is a perfect location to study the evolution of FAT belts because of the exceptional outcropping conditions of growth strata, the proven diachronic kinematics and the non-coaxial interference of deformation events. Within the vast catalogue of complex structures that includes superposed folding, conical and plunging folds, oblique thrust ramps, etc here, we have selected the westernmost termination of the South Pyrenean sole thrust to illustrate how the integration of geometric and kinematic analysis can help unraveling complex structures in FAT belts. The San Marzal pericline (4 km2 surface extension) is the lateral termination of the Sto. Domingo deca-kilometric fold. San Marzal looks like a large 70° plunging cylindrical structure. However the large magnitude (≡ 60-70°) of vertical axis rotations accommodated between its flanks cannot be explained without a conical geometry. In this work we will show how the structural analysis performed on this structure has disentangled its complex geometry. This analyses comprises several hundreds of bedding data, joints and veins and more than 150 standard paleomagnetic and AMS sites. Besides, we will show how the kinematic information derived from magnetostratigraphic sections (more than 8 km of sampled profiles) has helped to constraint the folding and rotation ages and velocities. Finally, all these complex geometric and kinematic features have inspired us to build an analogue model where we can explore the 3D

  8. Research Article Special Issue

    African Journals Online (AJOL)



    Oct 17, 2017 ... 2017, 9(5S), 23-32. 23. 1. INTRODUCTION. Data visualization is a term used for visual images that help users to understand complex data [1] through their patterns ..... For evaluation, a dataset used is from a research center called Green Energy Research ... The solar photovoltaic data at the overview level.

  9. Information for Developing Countries: Definitions, Institutions and Issues. A Contribution towards Forming an Understanding of the Potential for Consultancy, Marketing and Training Related Activities. Kingston Polytechnic School of Information Systems Research Report 87-3. (United States)

    Lindsay, John

    This paper reports on the emerging market in information on development-related activities in terms of the European capacity in databases and information networking. The first of its two parts addresses issues that are emerging consequent to the introduction of information technology in developing countries. Problems of definition and interest in…

  10. Communication Complexity

    Indian Academy of Sciences (India)

    Jaikumar Radhakrishnan

    Communication complexity. Motivation . . . An abstract model to study the communicaiton required for computation. A tool for showing lower bounds in several computational models. The study often requires deep understanding of computation using tools from combinatorics, coding theory, algebra, analysis, etc. Jaikumar ...

  11. Understanding land administration systems

    DEFF Research Database (Denmark)

    P. Williamson, Ian; Enemark, Stig; Wallace, Judy


    This paper introduces basic land administration theory and highlights four key concepts that are fundamental to understanding modern land administration systems. Readers may recall the first part of the paper in October issue of Coordinates. Here is the concluding part that focuses on the changing...

  12. Postmodern imaginative constructivism for STSE understanding (United States)

    Robertson, Christian

    The influences of science and technology on society and the environment (STSE) have been an integral component of the formal educational curricula for four decades, and yet industrialized countries frequently struggle to balance the benefits of science and technology with the social justice and environmental issues inherent to contemporary society. Canadian citizens often fail to connect scientific and technological understandings with the subtle and yet ubiquitous personal, political, cultural, environmental, and social consequences that result from these understandings. This phenomenological research will explore potential discourses of control within education and society that may preclude authentic, contextual, and meaningful understandings of science and technology relative to their significant consequences, and an imaginative adaptation of Egan's Ironic Understanding and McGinn's Foreground and Background Dimensions to imaginatively express an awareness of postmodern STSE understandings. This research is designed to explore student understandings of how the diverse and complex influences of science and technology affect students through postmodern, imaginative, and constructivist photography. Participants demonstrated a limited Ironic Understanding of STSE, a critical awareness of specific modernist influences, increased personal and affective connections to science and technology, and an awareness of the duality of STSE. Participants' photographic artifacts can be utilized to inform teaching and learning strategies in order to purposefully craft curriculum and lesson plan design for personalized and engaging learning opportunities that incorporate students' awareness of STSE.

  13. Understanding the complexity of human gait dynamics (United States)

    Scafetta, Nicola; Marchi, Damiano; West, Bruce J.


    Time series of human gait stride intervals exhibit fractal and multifractal properties under several conditions. Records from subjects walking at normal, slow, and fast pace speed are analyzed to determine changes in the fractal scalings as a function of the stress condition of the system. Records from subjects with different age from children to elderly and patients suffering from neurodegenerative disease are analyzed to determine changes in the fractal scalings as a function of the physical maturation or degeneration of the system. A supercentral pattern generator model is presented to simulate the above two properties that are typically found in dynamical network performance: that is, how a dynamical network responds to stress and to evolution.

  14. Neuroscience-Enabled Complex Visual Scene Understanding (United States)


    34, Rivista di Psicologia 49 (1): 7–30 • Kauppinen, Hannu. Seppanen, Tapio and Pietikainen, Matti. An Experimental Comparison of Autoregressive and...a Social Robot,“ IJCAI, pp. 1146-1151, 1999. [63] G. Heidemann, R. Rae, H. Bekel, I. Bax, and H. Ritter, ”Inte- grating Context-free and Context... social interaction. In Interna- tional Conference on Robotics, Automation, and Mecha- tronics (RAM 2006), Bangkok Thailand. Se, S., Lowe, D. G

  15. Understanding classification

    NARCIS (Netherlands)

    Subianto, M.


    In practical data analysis, the understandability of models plays an important role in their acceptance. In the data mining literature, however, understandability plays is hardly ever mentioned. If it is mentioned, it is interpreted as meaning that the models have to be simple. In this thesis we

  16. Embodied understanding. (United States)

    Johnson, Mark


    Western culture has inherited a view of understanding as an intellectual cognitive operation of grasping of concepts and their relations. However, cognitive science research has shown that this received intellectualist conception is substantially out of touch with how humans actually make and experience meaning. The view emerging from the mind sciences recognizes that understanding is profoundly embodied, insofar as our conceptualization and reasoning recruit sensory, motor, and affective patterns and processes to structure our understanding of, and engagement with, our world. A psychologically realistic account of understanding must begin with the patterns of ongoing interaction between an organism and its physical and cultural environments and must include both our emotional responses to changes in our body and environment, and also the actions by which we continuously transform our experience. Consequently, embodied understanding is not merely a conceptual/propositional activity of thought, but rather constitutes our most basic way of being in, and engaging with, our surroundings in a deep visceral manner.

  17. Complex Covariance

    Directory of Open Access Journals (Sweden)

    Frieder Kleefeld


    Full Text Available According to some generalized correspondence principle the classical limit of a non-Hermitian quantum theory describing quantum degrees of freedom is expected to be the well known classical mechanics of classical degrees of freedom in the complex phase space, i.e., some phase space spanned by complex-valued space and momentum coordinates. As special relativity was developed by Einstein merely for real-valued space-time and four-momentum, we will try to understand how special relativity and covariance can be extended to complex-valued space-time and four-momentum. Our considerations will lead us not only to some unconventional derivation of Lorentz transformations for complex-valued velocities, but also to the non-Hermitian Klein-Gordon and Dirac equations, which are to lay the foundations of a non-Hermitian quantum theory.

  18. Complex Networks

    CERN Document Server

    Evsukoff, Alexandre; González, Marta


    In the last decade we have seen the emergence of a new inter-disciplinary field focusing on the understanding of networks which are dynamic, large, open, and have a structure sometimes called random-biased. The field of Complex Networks is helping us better understand many complex phenomena such as the spread of  deseases, protein interactions, social relationships, to name but a few. Studies in Complex Networks are gaining attention due to some major scientific breakthroughs proposed by network scientists helping us understand and model interactions contained in large datasets. In fact, if we could point to one event leading to the widespread use of complex network analysis is the availability of online databases. Theories of Random Graphs from Erdös and Rényi from the late 1950s led us to believe that most networks had random characteristics. The work on large online datasets told us otherwise. Starting with the work of Barabási and Albert as well as Watts and Strogatz in the late 1990s, we now know th...

  19. Understanding semantics

    DEFF Research Database (Denmark)

    Thrane, Torben


    Understanding natural language is a cognitive, information-driven process. Discussing some of the consequences of this fact, the paper offers a novel look at the semantic effect of lexical nouns and the identification of reference types....

  20. How Do We Teach What Is Right? Research and Issues in Ethical and Moral Development. (United States)

    Perry, Constance M.


    Enhances understanding of values-education issues by addressing research on moral and ethical development. Presents Damon's tripartite distinction among moral reflection, moral emotion, and moral conduct--head, heart, and habit--to show moral development's complexity. Although promoting prosocial behavior is parents' responsibility, literature is…

  1. Understanding homelessness


    Somerville, Peter


    This paper reviews the literature on understanding homelessness. It criticizes approaches that ignore, distort or diminish the humanity of homeless people, or else, add little to our understanding of that humanity. In particular, it rejects what it calls “epidemiological” approaches, which deny the possibility of agency for homeless people, insofar as those approaches view the situation of those people largely as a “social fact”, to be explained in terms of causal variables or “risk factors” ...

  2. Metabolomics: towards understanding traditional Chinese medicine. (United States)

    Zhang, Aihua; Sun, Hui; Wang, Zhigang; Sun, Wenjun; Wang, Ping; Wang, Xijun


    Metabolomics represent a global understanding of metabolite complement of integrated living systems and dynamic responses to the changes of both endogenous and exogenous factors and has many potential applications and advantages for the research of complex systems. As a systemic approach, metabolomics adopts a "top-down" strategy to reflect the function of organisms from the end products of the metabolic network and to understand metabolic changes of a complete system caused by interventions in a holistic context. This property agrees with the holistic thinking of Traditional Chinese Medicine (TCM), a complex medical science, suggesting that metabolomics has the potential to impact our understanding of the theory behind the evidence-based Chinese medicine. Consequently, the development of robust metabolomic platforms will greatly facilitate, for example, the understanding of the action mechanisms of TCM formulae and the analysis of Chinese herbal (CHM) and mineral medicine, acupuncture, and Chinese medicine syndromes. This review summarizes some of the applications of metabolomics in special TCM issues with an emphasis on metabolic biomarker discovery. © Georg Thieme Verlag KG Stuttgart · New York.

  3. Understanding ADHD: Symptoms in Children (United States)

    ... this page please turn JavaScript on. Feature: Understanding ADHD Symptoms In Children Past Issues / Spring 2014 Table ... hyperactivity, and impulsivity are the key behaviors of ADHD. It is normal for all children to be ...

  4. Understanding Haiti. (United States)

    Caines, Heather; And Others


    Provides teachers, librarians, and general readers with resources to educate themselves and others about the complex reality of today's Haiti. It offers an introduction to Haiti's history, politics, society, and culture and cites works available within the following categories: children's/young adults' books, literature, film and video, and music.…

  5. Managing Complexity

    Energy Technology Data Exchange (ETDEWEB)

    Chassin, David P.; Posse, Christian; Malard, Joel M.


    Physical analogs have shown considerable promise for understanding the behavior of complex adaptive systems, including macroeconomics, biological systems, social networks, and electric power markets. Many of today’s most challenging technical and policy questions can be reduced to a distributed economic control problem. Indeed, economically-based control of large-scale systems is founded on the conjecture that the price-based regulation (e.g., auctions, markets) results in an optimal allocation of resources and emergent optimal system control. This paper explores the state of the art in the use physical analogs for understanding the behavior of some econophysical systems and to deriving stable and robust control strategies for them. In particular we review and discussion applications of some analytic methods based on the thermodynamic metaphor according to which the interplay between system entropy and conservation laws gives rise to intuitive and governing global properties of complex systems that cannot be otherwise understood.

  6. Understanding physics

    CERN Document Server

    Mansfield, Michael


    Understanding Physics - Second edition is a comprehensive, yet compact, introductory physics textbook aimed at physics undergraduates and also at engineers and other scientists taking a general physics course. Written with today's students in mind, this text covers the core material required by an introductory course in a clear and refreshing way. A second colour is used throughout to enhance learning and understanding. Each topic is introduced from first principles so that the text is suitable for students without a prior background in physics. At the same time the book is designed to enable

  7. The railroad perspective: Issues behind the issues

    International Nuclear Information System (INIS)

    Furber, C.P.; Brobst, W.A.


    Rail transportation is a vital segment of DOE's spent fuel program. Most of the shipments from reactors to a repository or to a Monitored Retrievable Storage facility will be by rail, and essentially all of the shipments from an MRS to a repository. Casks must move economically and efficiently, while at the same time providing adequate safety to the public and transport workers, and meeting the legal/institutional constraints. Shippers are faced with the problem of procuring transportation services in a safe manner at a reasonable cost, trying to balance freight charges against cask inventory costs. Carriers are cautious about accepting potentially high hazard materials in routine service, and are worried about uninsured losses in case of accidents. Both shippers and carriers operate under different scheduling and operational criteria. Technical and institutional constraints add to the complexity of the operation. Standardization of shipping casks and rail car design will ease the resolution of the complex problems now existent. This paper discusses the economic, safety, operational, and legal issues surrounding rail transportation

  8. Editorial Statement: Second Issue

    Directory of Open Access Journals (Sweden)

    Mustafa Yunus Eryaman


    Full Text Available We are pleased to present the second issue of the International Journal of Progressive Education (IJPE. Since the publication of the first issue in February 2005, an extensive amount of gratitude and positive feedbacks as well as an increasing number of paper submissions we have received from all parts of the academic world confirm that the existence of such an international and multilingual journal can be very beneficial to provide a platform for cross-cultural discussion and understanding of educational theory and practice. In addition, the contributions to the journal and the requests for special issues from across the globe such as from North America, Africa, Middle East, Europe and Eastern Asia convince us that IJPE is making a significant progress toward one of its mission of providing a glocal atmosphere and ongoing dialogue to globally represent multiple and local views on educational issues. Doubtlessly, such evidences have been given us additional confidence, power and strong belief to continue with what we are trying to accomplish. We would like to thank you for your encouragements and constructive suggestions and request that please continue to do so in order to make this journal successful and vibrant.

  9. Understanding pastoral mobility

    DEFF Research Database (Denmark)

    Adriansen, Hanne Kirstine


    Based on a case study from Sahelian Senegal, this paper analyses how various actors perceive the importance of pastoral mobility and presents issues of importance for understanding the use of mobility among Fulani of Ferlo. One knowledge system is a scientific one, the 'new rangeland paradigm...... territory, which they consider their place, but are unwilling to employ large-scale mobility themselves. Mobility is not of importance for their ethnic identity and some use paid herders to care for their livestock. By looking at both knowledge systems, we achieve a better understanding of pastoral mobility...

  10. Understanding Energy (United States)

    Menon, Deepika; Shelby, Blake; Mattingly, Christine


    "Energy" is a term often used in everyday language. Even young children associate energy with the food they eat, feeling tired after playing soccer, or when asked to turn the lights off to save light energy. However, they may not have the scientific conceptual understanding of energy at this age. Teaching energy and matter could be…

  11. Organizational issues = change. (United States)

    Lorenzi, Nancy M; Riley, Robert T


    Information systems fail for a number of reasons. Several failure reasons include communication, complexity, organization, technology, and leadership. Failure can be outlined in four major categories: technical shortcomings, project management shortcomings, organizational issues, and the continuing information explosion. Change management is the process of assisting individuals and organizations in passing from an old way of doing things to a new way of doing things. Change management starts early in a technical process, as the need for making major changes starts at the conceptual level. This paper briefly covers the people side of implementing new information systems, and describes resistance to change and various strategies to manage technological change.

  12. A scoping review and thematic classification of patient complexity: offering a unifying framework

    Directory of Open Access Journals (Sweden)

    Alexis K. Schaink


    Full Text Available The path to improving healthcare quality for individuals with complex health conditions is complicated by a lack of common understanding of complexity. Modern medicine, together with social and environmental factors, has extended life, leading to a growing population of patients with chronic conditions. In many cases, there are social and psychological factors that impact treatment, health outcomes, and quality of life. This is the face of complexity. Care challenges, burden, and cost have positioned complexity as an important health issue. Complex chronic conditions are now being discussed by clinicians, researchers, and policy-makers around such issues as quantification, payment schemes, transitions, management models, clinical practice, and improved patient experience. We conducted a scoping review of the literature for definitions and descriptions of complexity. We provide an overview of complex chronic conditions, and what is known about complexity, and describe variations in how it is understood. We developed a Complexity Framework from these findings to guide our approach to understanding patient complexity. It is critical to use common vernacular and conceptualization of complexity to improve service and outcomes for patients with complex chronic conditions. Many questions still persist about how to develop this work with a health and social care lens; our framework offers a foundation to structure thinking about complex patients. Further insight into patient complexity can inform treatment models and goals of care, and identify required services and barriers to the management of complexity.

  13. Complex analysis

    CERN Document Server

    Freitag, Eberhard


    The guiding principle of this presentation of ``Classical Complex Analysis'' is to proceed as quickly as possible to the central results while using a small number of notions and concepts from other fields. Thus the prerequisites for understanding this book are minimal; only elementary facts of calculus and algebra are required. The first four chapters cover the essential core of complex analysis: - differentiation in C (including elementary facts about conformal mappings) - integration in C (including complex line integrals, Cauchy's Integral Theorem, and the Integral Formulas) - sequences and series of analytic functions, (isolated) singularities, Laurent series, calculus of residues - construction of analytic functions: the gamma function, Weierstrass' Factorization Theorem, Mittag-Leffler Partial Fraction Decomposition, and -as a particular highlight- the Riemann Mapping Theorem, which characterizes the simply connected domains in C. Further topics included are: - the theory of elliptic functions based on...

  14. The US framework for understanding, preventing, and caring for the mental health needs of service members who served in combat in Afghanistan and Iraq: a brief review of the issues and the research

    Directory of Open Access Journals (Sweden)

    Carl Andrew Castro


    Full Text Available This paper reviews the psychological health research conducted in the United States in support of combat veterans from Iraq and Afghanistan, using the Military Psychological Health Research Continuum, which includes foundational science, epidemiology, etiology, prevention and screening, treatment, follow-up care, and services research. The review is limited to those studies involving combat veterans and military families. This review discusses perplexing issues regarding the impact of combat on the mental health of service members such as risk and resilience factors of mental health, biomarkers of posttraumatic stress syndrome (PTSD, mental health training, psychological screening, psychological debriefing, third location decompression, combat and suicide, the usefulness of psychotherapy and drug therapy for treating PTSD, role of advanced technology, telemedicine and virtual reality, methods to reduce stigma and barriers to care, and best approaches to the dissemination of evidence-based interventions. The mental health research of special populations such as women, National Guardsmen and reservists, and military families is also presented. The review concludes by identifying future areas of research.

  15. Understanding Acne: How to Banish Breakouts (United States)

    ... Issues Subscribe January 2010 Print this issue Understanding Acne How to Banish Breakouts Send us your comments ... Protect Your Skin from Sun Damage Wise Choices Acne Flare-ups The exact cause of acne is ...

  16. Understanding translation

    DEFF Research Database (Denmark)

    Schjoldager, Anne Gram; Gottlieb, Henrik; Klitgård, Ida

    Understanding Translation is designed as a textbook for courses on the theory and practice of translation in general and of particular types of translation - such as interpreting, screen translation and literary translation. The aim of the book is to help you gain an in-depth understanding...... of the phenomenon of translation and to provide you with a conceptual framework for the analysis of various aspects of professional translation. Intended readers are students of translation and languages, but the book will also be relevant for others who are interested in the theory and practice of translation...... - translators, language teachers, translation users and literary, TV and film critics, for instance. Discussions focus on translation between Danish and English....

  17. Understanding Resilience

    Directory of Open Access Journals (Sweden)

    Gang eWu


    Full Text Available Resilience is the ability to adapt successfully in the face of stress and adversity. Stressful life events, trauma and chronic adversity can have a substantial impact on brain function and structure, and can result in the development of PTSD, depression and other psychiatric disorders. However, most individuals do not develop such illnesses after experiencing stressful life events, and are thus thought to be resilient. Resilience as successful adaptation relies on effective responses to environmental challenges and ultimate resistance to the deleterious effects of stress, therefore a greater understanding of the factors that promote such effects is of great relevance. This review focuses on recent findings regarding genetic, epigenetic, developmental, psychosocial and neurochemical factors that are considered essential contributors to the development of resilience. Neural circuits and pathways involved in mediating resilience are also discussed. The growing understanding of resilience factors will hopefully lead to the development of new pharmacological and psychological interventions for enhancing resilience and mitigating the untoward consequences.

  18. Understand electronics

    CERN Document Server

    Bishop, Owen


    Understand Electronics provides a readable introduction to the exciting world of electronics for the student or enthusiast with little previous knowledge. The subject is treated with the minimum of mathematics and the book is extensively illustrated.This is an essential guide for the newcomer to electronics, and replaces the author's best-selling Beginner's Guide to Electronics.The step-by-step approach makes this book ideal for introductory courses such as the Intermediate GNVQ.

  19. Understanding users

    DEFF Research Database (Denmark)

    Johannsen, Carl Gustav Viggo


    Segmentation of users can help libraries in the process of understanding user similarities and differences. Segmentation can also form the basis for selecting segments of target users and for developing tailored services for specific target segments. Several approaches and techniques have been...... segmentation project using computer-generated clusters. Compared to traditional marketing texts, this article also tries to identify user segments or images or metaphors by the library profession itself....

  20. Understanding unemployment


    Guillaume Rocheteau


    Modern economists have built models of the labor market, which isolate the market’s key drivers and describe the way these interact to produce particular levels of unemployment. One of the most popular models used by macroeconomists today is the search-matching model of equilibrium unemployment. We explain this model, and show how it can be applied to understand the way various policies, such as unemployment benefits, taxes, or technological changes, can affect the unemployment rate.

  1. Understanding Technology?

    Directory of Open Access Journals (Sweden)

    Erik Bendtsen


    Full Text Available We are facing radical changes in our ways of living in the nearest future. Not necessarily of our own choice, but because tchnological development is moving so fast, that it will have still greater impact on many aspects of our lives. We have seen the beginnings of that change within the latest 35 years or so, but according to newest research that change will speed up immensely in the nearest years to come. The impact of that change or these changes will affect our working life immensely as a consequence of automation. How these changes are brought about and which are their consequences in a broad sense is being attempted to be understood and guessed by researchers. No one knows for sure, but specific patterns are visible. This paper will not try to guess, what will come, but will rather try to understand the deepest ”nature” of technology in order to understand the driving factors in this development: the genesis of technology in a broad sense in order to contibute to the understanding of the basis for the expected development.

  2. Risk-communication issues in radiation safety: еvaluation of public awareness in St. Petersburg and the Leningrad region on the activities of the nuclear industry and public understanding of the hazards

    Directory of Open Access Journals (Sweden)

    G. V. Arkhangelskaya


    Full Text Available In 2016, St. Petersburg Research Institute of Radiation Hygiene named after Professor P.V. Ramzaev developed a Program for the radiation risk communication management for the adequate perception risks associated with the use of various technologies in the nuclear industry by the public. Carrying out sociological research is one of the stages of this program. The aim of the analysis presented in the article is to study the population’s awareness of radiation safety issues and its attitude to further development of the nuclear industry. The data used in this analysis is a part of a large sociological survey conducted in St. Petersburg and the Leningrad Region The sociological research was conducted by the method of a selective questionnaire survey among the adult population permanently residing in the territory of St. Petersburg and the Leningrad Region. The volume of the sample studied was 2369 respondents: 1006 in St. Petersburg and 1363 in the Leningrad Region, including Sosnovy Bor – 401. The analysis showed that the population of all the studied territories estimates the environmental situation as being mainly favorable. The residents consider the main environmental problems in all areas studied to be a collection, removal, storage, disposal of garbage, as well as air and water pollution. The population of the region is relatively poorly informed about the current projects in the nuclear industry. One-third of the inhabitants of the region perceives the Leningrad nuclear power plant as a source of danger. Respondents see the main danger in the possibility of an accident on it. There is a sharply negative attitude of the population towards the construction of radioactive waste disposal sites anywhere in the region. According to the results of the study, it can be concluded that the population of the studied region is poorly informed about the existing radiation situation and the nuclear industry projects. It requires an optimization of the

  3. Complexity, Modeling, and Natural Resource Management

    Directory of Open Access Journals (Sweden)

    Paul Cilliers


    Full Text Available This paper contends that natural resource management (NRM issues are, by their very nature, complex and that both scientists and managers in this broad field will benefit from a theoretical understanding of complex systems. It starts off by presenting the core features of a view of complexity that not only deals with the limits to our understanding, but also points toward a responsible and motivating position. Everything we do involves explicit or implicit modeling, and as we can never have comprehensive access to any complex system, we need to be aware both of what we leave out as we model and of the implications of the choice of our modeling framework. One vantage point is never sufficient, as complexity necessarily implies that multiple (independent conceptualizations are needed to engage the system adequately. We use two South African cases as examples of complex systems - restricting the case narratives mainly to the biophysical domain associated with NRM issues - that make the point that even the behavior of the biophysical subsystems themselves are already complex. From the insights into complex systems discussed in the first part of the paper and the lessons emerging from the way these cases have been dealt with in reality, we extract five interrelated generic principles for practicing science and management in complex NRM environments. These principles are then further elucidated using four further South African case studies - organized as two contrasting pairs - and now focusing on the more difficult organizational and social side, comparing the human organizational endeavors in managing such systems.

  4. Issues Management Process Course # 38401

    Energy Technology Data Exchange (ETDEWEB)

    Binion, Ula Marie [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    The purpose of this training it to advise Issues Management Coordinators (IMCs) on the revised Contractor Assurance System (CAS) Issues Management (IM) process. Terminal Objectives: Understand the Laboratory’s IM process; Understand your role in the Laboratory’s IM process. Learning Objectives: Describe the IM process within the context of the CAS; Describe the importance of implementing an institutional IM process at LANL; Describe the process flow for the Laboratory’s IM process; Apply the definition of an issue; Use available resources to determine initial screening risk levels for issues; Describe the required major process steps for each risk level; Describe the personnel responsibilities for IM process implementation; Access available resources to support IM process implementation.

  5. Boundary issues (United States)

    Townsend, Alan R.; Porder, Stephen


    What is our point of no return? Caesar proclaimed 'the die is cast' while crossing the Rubicon, but rarely does modern society find so visible a threshold in our continued degradation of ecosystems and the services they provide. Humans have always used their surroundings to make a living— sometimes successfully, sometimes not (Diamond 2005)—and we intuitively know that there are boundaries to our exploitation. But defining these boundaries has been a challenge since Malthus first prophesied that nature would limit the human population (Malthus 1798). In 2009, Rockström and colleagues tried to quantify what the 6.8 billion (and counting) of us could continue to get away with, and what we couldn't (Rockström et al 2009). In selecting ten 'planetary boundaries', the authors contend that a sustainable human enterprise requires treating a number of environmental thresholds as points of no return. They suggest we breach these Rubicons at our own peril, and that we've already crossed three: biodiversity loss, atmospheric CO2, and disruption of the global nitrogen (N) cycle. As they clearly hoped, the very act of setting targets has provoked scientific inquiry about their accuracy, and about the value of hard targets in the first place (Schlesinger 2009). Such debate is a good thing. Despite recent emphasis on the science of human-ecosystem interactions, understanding of our planetary boundaries is still in its infancy, and controversy can speed scientific progress (Engelhardt and Caplan 1987). A few weeks ago in this journal, Carpenter and Bennett (2011) took aim at one of the more controversial boundaries in the Rockström analysis: that for human alteration of the global phosphorus (P) cycle. Rockström's group chose riverine P export as the key indicator, suggesting that humans should not exceed a value that could trigger widespread marine anoxic events—and asserting that we have not yet crossed this threshold. There are defensible reasons for a marine

  6. Understanding bulimia. (United States)

    Hay, Phillipa J


    Bulimia nervosa (BN) and related eating disorders such as binge eating disorder are common. General practitioners can play a key role in the identification and management of BN and related eating disorders. This article describes the presenting and associated features of BN and overviews evidence based treatment approaches. Key features are recurrent episodes of binge eating, extreme weight control behaviours and over concern about weight and shape issues. By definition people are not underweight. Risk factors include being from a western culture, obesity, exposure to a restrictive dieting environment and low self esteem. People are more likely to present asking for help in weight control or a physical problem secondary to the eating disorder. Evidenced based therapies with good outcomes in current use are cognitive behaviour therapy (in full or guided self help forms), high dose fluoxetine, and interpersonal psychotherapy. It is important to convey optimism about treatment efficacy and outcomes.

  7. Understanding uncertainty

    CERN Document Server

    Lindley, Dennis V


    Praise for the First Edition ""...a reference for everyone who is interested in knowing and handling uncertainty.""-Journal of Applied Statistics The critically acclaimed First Edition of Understanding Uncertainty provided a study of uncertainty addressed to scholars in all fields, showing that uncertainty could be measured by probability, and that probability obeyed three basic rules that enabled uncertainty to be handled sensibly in everyday life. These ideas were extended to embrace the scientific method and to show how decisions, containing an uncertain element, could be rationally made.

  8. Introduction to the Special Issue: Coastal GIS

    Directory of Open Access Journals (Sweden)

    Timothy Nyerges


    Full Text Available This special issue of the ISPRS International Journal of Geographic Information about “Coastal GIS” is motivated by many circumstances. More than one-half of the world’s human population lives in coastal areas (within 200 kilometers of coast as of 2000 [1]. The trend toward coastal habitation is expected to continue in the US with the total being 75 percent by 2025, meaning that coastal human–environment interactions will likely increase and intensify [2]. Geographic information systems (GIS are being developed and used by technical specialists, stakeholder publics, and executive/policy decision makers for improving our understanding and management of coastal areas, separately and together as more organizations focus on improving the sustainability and resilience of coastal systems. Coastal systems—defined as the area of land closely connected to the sea, including barrier islands, wetlands, mudflats, beaches, estuaries, cities, towns, recreational areas, and maritime facilities, the continental seas and shelves, and the overlying atmosphere—are subject to complex and dynamic interactions among natural and human-driven processes. Coastal systems are crucial to regional and national economies, hosting valued human-built infrastructure and providing ecosystem services that sustain human well-being. This special issue of IJGI about coastal GIS presents a collection of nine papers that address many of the issues mentioned above. [...

  9. Understanding Sex for Sale

    DEFF Research Database (Denmark)

    This book Understanding Sex for Sale: Meanings and Moralities of Sexual Commerce is dedicated to the exploration of the ways in which sex prostitution, sex work or sex for sale are taken for granted by particularly looking at how the relation between sex and money is interpreted and enacted....... This interdisciplinary book aims to understand how prostitution, sex work or sex for sale are defined, delineated, contested and understood in different places and times. The book offers contributions from a number of scholars who, based on their on their own research, discuss on going theoretical issues and analytical...... challenges Some chapters focuses on how prostitution, sex work or sex for sale have been regulated by the authorities and what understandings this regulation builds on. Other chapters investigate the experiences of the sex workers and sex buyers asking how these actors adjust to or resist the categorisation...

  10. Understanding analysis

    CERN Document Server

    Abbott, Stephen


    This lively introductory text exposes the student to the rewards of a rigorous study of functions of a real variable. In each chapter, informal discussions of questions that give analysis its inherent fascination are followed by precise, but not overly formal, developments of the techniques needed to make sense of them. By focusing on the unifying themes of approximation and the resolution of paradoxes that arise in the transition from the finite to the infinite, the text turns what could be a daunting cascade of definitions and theorems into a coherent and engaging progression of ideas. Acutely aware of the need for rigor, the student is much better prepared to understand what constitutes a proper mathematical proof and how to write one. Fifteen years of classroom experience with the first edition of Understanding Analysis have solidified and refined the central narrative of the second edition. Roughly 150 new exercises join a selection of the best exercises from the first edition, and three more project-sty...

  11. Understanding ayurveda. (United States)

    Gadgil, Vaidya Dilip


    Ayurveda needs to achieve its full potential both in India and globally. This requires imparting to its students full appreciation of Ayurveda's power and strength, particularly proper understanding of the advantages of applying it to treat chronic and acute diseases. To this end, we explain the necessity of learning Sanskrit as a medium of study, and the advantages of learning the Texts in the traditional way, rather than relying on translations with all the loss of meaning and precision, which that entails. We emphasize the use of Triskandhakosha as a means to fully understand Ayurveda fundamental concepts and technical terms, so that all their shades of meaning are fully understood, and all their usages given in different places in the texts. Only by such methods can full appreciation of Ayurvedic wisdom be achieved, and the full depth and power of its knowledge be applied. Only then will its true status among systems of medicine come to be appreciated, either in India or more widely in the world as a whole.

  12. Understanding Ayurveda

    Directory of Open Access Journals (Sweden)

    Vaidya Dilip Gadgil


    Full Text Available Ayurveda needs to achieve its full potential both in India and globally. This requires imparting to its students full appreciation of Ayurveda′s power and strength, particularly proper understanding of the advantages of applying it to treat chronic and acute diseases. To this end, we explain the necessity of learning Sanskrit as a medium of study, and the advantages of learning the Texts in the traditional way, rather than relying on translations with all the loss of meaning and precision, which that entails. We emphasize the use of Triskandhakosha as a means to fully understand Ayurveda fundamental concepts and technical terms, so that all their shades of meaning are fully understood, and all their usages given in different places in the texts. Only by such methods can full appreciation of Ayurvedic wisdom be achieved, and the full depth and power of its knowledge be applied. Only then will its true status among systems of medicine come to be appreciated, either in India or more widely in the world as a whole.

  13. In This Issue (United States)


    Organic Chemistry--New Challenges Perhaps more than any other of the chemical subdisciplines, the scope and focus of organic chemistry has been changed by modern technology and theoretical advances, and these changes have had an equally striking effect on the undergraduate curriculum. The main challenge in organic chemistry classes has shifted, in less than a generation, from memorizing all the groups, naming conventions, and classes of reactions to understanding complex interactions at the structural and electronic orbital level. As biochemistry and polymer chemistry have grown from being the purview of a few specialists to full-blown disciplines of their own, they have also migrated from interesting, but optional, chapters at the back of the book to separate courses in the curriculum. The availability of inexpensive instrumentation means undergraduates routinely use NMR and mass spec instead of melting points to identify their products. And the changes are continuing: segments of biochemistry are metamorphizing into molecular biology and polymer chemistry is finding interconnections with materials science. In fact, as our understanding of chemical reactions at molecular and electronic levels expands, it becomes more and more difficult to decide on demarcations between the subdisciplines. Organic chemistry is an organizational construct that once was useful for segregating certain topics into a coherent two-semester introductory course. Today, it covers so much territory that no one who is an "organic chemist" can know even a small fraction of the territory and faces unique challenges when designing and teaching undergraduate courses. In a wide spectrum of articles in this issue that fall under the "organic" umbrella--from environmental chemistry to new polymer products--teachers share their specific experiences and creative solutions to these challenges, providing their colleagues with new ideas, processes, and pedagogic approaches. To start off, we can examine

  14. Social media and social work education: understanding and dealing with the new digital world. (United States)

    Fang, Lin; Mishna, Faye; Zhang, Vivian F; Van Wert, Melissa; Bogo, Marion


    Accompanying the multiple benefits and innovations of social media are the complex ethical and pedagogical issues that challenge social work educators. Without a clear understanding of the blurred boundaries between public and private, the potentially limitless and unintended audiences, as well as the permanency of the information shared online, social work students who use social media can find themselves in difficult situations in their personal and professional lives. In this article, we present three scenarios that illustrate issues and complexities involving social media use by social work students, followed by a discussion and recommendations for social work educators.

  15. Understanding the spermatozoon. (United States)

    Neri, Queenie V; Hu, Jennifer; Rosenwaks, Zev; Palermo, Gianpiero D


    The former perception of the spermatozoon as a delivery device of the male genome has been expanded to include a new understanding of the cell's complex role in fertilization. Once the spermatozoon reaches the oocyte, it triggers egg activation and orchestrates the stages of pre- and post-fertilization in a preprogrammed pattern while tapping the oocyte's resources in an effort to generate a new life.

  16. Understanding physics

    CERN Document Server

    Cassidy, David; Rutherford, James


    Understanding Physics provides a thorough grounding in contemporary physics while placing physics into its social and historical context Based in large part on the highly respected Project Physics Course developed by two of the authors, it also integrates the results of recent pedagogical research The text thus - teaches about the basic phenomena in the physical world and the concepts developed to explain them - shows that science is a rational human endeavor with a long and continuing tradition, involving many different cultures and people - develops facility in critical thinking, reasoned argumentation, evaluation of evidence, mathematical modeling, and ethical values The treatment emphasizes not only what we know but also how we know it, why we believe it, and what effects that knowledge has - Why do we believe the Earth and planets revolve around the Sun? - Why do we believe that matter is made of atoms? - How do relativity theory and quantum mechanics alter our conception of Nature and in what ways do th...

  17. Life Complexity and Diversity

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 1; Issue 12. Life Complexity and Diversity Whither Diversity. Madhav Gadgil. Series Article Volume 1 Issue 12 December 1996 pp 17-25. Fulltext. Click here to view fulltext PDF. Permanent link: ...

  18. Life: Complexity and Diversity

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 1; Issue 4. Life : Complexity and Diversity Growing Larger. Madhav Gadgil. Series Article Volume 1 Issue 4 April 1996 pp 15-22. Fulltext. Click here to view fulltext PDF. Permanent link: ...

  19. Complicating Issues in Holocaust Education (United States)

    Lindquist, David H.


    Confronting the Holocaust in a classroom setting involves a complex undertaking that demands careful planning as educators develop and present curricula on the subject to their students. This article explores another problematic factor involved in teaching the Shoah, that is, several issues that exist outside the content/pedagogical framework but…

  20. Understanding noninferiority trials

    Directory of Open Access Journals (Sweden)

    Seokyung Hahn


    Full Text Available Noninferiority trials test whether a new experimental treatment is not unacceptably less efficacious than an active control treatment already in use. With continuous improvements in health technologies, standard care, and clinical outcomes, the incremental benefits of newly developed treatments may be only marginal over existing treatments. Sometimes assigning patients to a placebo is unethical. In such circumstances, there has been increasing emphasis on the use of noninferiority trial designs. Noninferiority trials are more complex to design, conduct, and interpret than typical superiority trials. This paper reviews the concept of noninferiority trials and discusses some important issues related to them.

  1. Channelopathies from mutations in the cardiac sodium channel protein complex. (United States)

    Adsit, Graham S; Vaidyanathan, Ravi; Galler, Carla M; Kyle, John W; Makielski, Jonathan C


    The cardiac sodium current underlies excitability in heart, and inherited abnormalities of the proteins regulating and conducting this current cause inherited arrhythmia syndromes. This review focuses on inherited mutations in non-pore forming proteins of sodium channel complexes that cause cardiac arrhythmia, and the deduced mechanisms by which they affect function and dysfunction of the cardiac sodium current. Defining the structure and function of these complexes and how they are regulated will contribute to understanding the possible roles for this complex in normal and abnormal physiology and homeostasis. This article is part of a Special Issue entitled "Na(+) Regulation in Cardiac Myocytes". Copyright © 2013 Elsevier Ltd. All rights reserved.

  2. Entanglement entropy and complexity for one-dimensional holographic superconductors

    Directory of Open Access Journals (Sweden)

    Mahdi Kord Zangeneh


    Full Text Available Holographic superconductor is an important arena for holography, as it allows concrete calculations to further understand the dictionary between bulk physics and boundary physics. An important quantity of recent interest is the holographic complexity. Conflicting claims had been made in the literature concerning the behavior of holographic complexity during phase transition. We clarify this issue by performing a numerical study on one-dimensional holographic superconductor. Our investigation shows that holographic complexity does not behave in the same way as holographic entanglement entropy. Nevertheless, the universal terms of both quantities are finite and reflect the phase transition at the same critical temperature.

  3. Translating key methodological issues into technological advancements when running in-situ experiments in sports: An example from sailing

    NARCIS (Netherlands)

    Pluijms, J.P.; Canal Bruland, R.; Kats, S.; Savelsbergh, G.J.P.


    In recent years there has been an increasing interest in capturing and understanding skilled performance by studying complex perceptual-motor skills. In this context, we identify and discuss key methodological issues that are particularly relevant when aiming to translate sport scientific knowledge

  4. Understanding PISA

    Directory of Open Access Journals (Sweden)

    Stephen DOWNES


    Full Text Available Understanding PISA Stephen DOWNESMoncton, CANADA ABSTRACT The headline was dramatic enough to cause a ripple in the reading public. "Students who use computers a lot at school have worse maths and reading performance," noted the BBC news article, citing a 2004 study by Ludger Woessmann and Thomas Fuchs (Fuchs and Woessman, 2004. It was not long before the blogosphere took notice. Taking the theme and running with it, Alice and Bill ask, "Computers Make School Kids Dumber?" They theorize, "If you track the admitted decline of education, you'll probably notice that it follows along with the increase of technology in the classroom." In a similar vein, James Bartholomew asks, "Do you think that the government will turn down the volume of its boasting about how it has spent billions introducing computers in schools (while keeping down the pay of teachers so much that there are shortages? Do you think it will stop sending governors of state schools glossy pamphlets about insisting that computers are used in their schools as much as possible?" In this study, therefore, PISA looks well beyond educational attainment, and also includes school demographics, such as whether it is a public or private school, has large or small classes, or has access or not to technological resources. Finally, it does measure student information-their family background, access to books and computers and parental support as well. The PISA survey departs from previous surveys in disregarding the stated curricula of the schools being measured. Therefore, the conclusion is not surprising, nor even wrong for him to consider independently of any parental or teacher support, considered without reference to the software running on it, considered without reference to student attitudes and interests, does not positively impact an education. Finally, he focus on missing the reporting of results

  5. Understanding Eating Disorders, Anorexia, Bulimia, and Binge-Eating (United States)

    ... Navigation Bar Home Current Issue Past Issues Understanding Eating Disorders Past Issues / Spring 2008 Table of Contents For ... this page please turn Javascript on. Photo: iStock Eating disorders, such as anorexia nervosa, bulimia nervosa, and binge ...

  6. Professional Emergence on Transnational Issues

    DEFF Research Database (Denmark)

    Seabrooke, Leonard; Tsingou, Eleni


    Addressing complex transnational problems requires coordination from different professionals. The emergence of new actors and issues has been addressed by those interested in studies of organizations through concepts and methods that highlight the importance of communities, fields, and networks....... These approaches are important in identifying the sources of what becomes established, but less geared to identifying interactions that are emergent. This article extends a linked ecologies approach to emergence, arguing that interaction on transnational issues should first be understood by how...... they are conceptually linked by actors and organizations. A linked ecologies approach asks us to displace locating known actors within structures and instead pays attention to professional interactions on how ‘issue distinctions’ are made, the relationship between issue distinctions and professional tasks, and who...

  7. Ophthalmology issues in schizophrenia. (United States)

    Gracitelli, Carolina P B; Abe, Ricardo Y; Diniz-Filho, Alberto; Vaz-de-Lima, Fabiana Benites; Paranhos, Augusto; Medeiros, Felipe A


    Schizophrenia is a complex mental disorder associated with not only cognitive dysfunctions, such as memory and attention deficits, but also changes in basic sensory processing. Although most studies on schizophrenia have focused on disturbances in higher-order brain functions associated with the prefrontal cortex or frontal cortex, recent investigations have also reported abnormalities in low-level sensory processes, such as the visual system. At very early stages of the disease, schizophrenia patients frequently describe in detail symptoms of a disturbance in various aspects of visual perception that may lead to worse clinical symptoms and decrease in quality of life. Therefore, the aim of this review is to describe the various studies that have explored the visual issues in schizophrenia.

  8. Understanding MARC: Another Look

    Directory of Open Access Journals (Sweden)

    Roy Chang


    Full Text Available 無MARC format has been widely used and discussed in our profession. However, there appear to have a wide spread misunderstanding of its real structure and attributes. This article discuss the needs for us to understand it a little more. Also, it presents the general misconceptions about MARC, the compatibility of MARC, the structure of MARC, standardization and - data communication, and some major issues related to MARC format. In this library automation age, MARC is a key element in library services, and it deserves us to take another look.

  9. Issue 6, Editorial

    Directory of Open Access Journals (Sweden)

    Judith Winters


    Full Text Available There has been more interest than I'd ever anticipated in issue 6 "Digital Publication", the first themed issue of Internet Archaeology - so much so that several more related articles have been submitted and will appear in issue 7! The discussion on linearity and hypertext, arising from the contributions by Cornelius Holtorf and Andre Costopoulos, also generated some serious and lengthy debate on our email discussion list intarch-interest for the first time too, and my thanks go out to all who participated - active authorship and readership in practice. Archaeologists are using the web and other electronic media more than ever now, but I believe that this is not just "because it's there". Theoretically and practically, the internet is a valuable tool for us. On the web, rather than on the printed page, we can come closer to fulfilling our concerns about dissemination, we can more easily incorporate many "voices" and facilitate the opening up of our work and our interpretations to critical inquiry, immediately and on a global scale. At the same time, the web also offers new and experimental ways of expressing and communicating our work, and the flexibility of the medium means that our information can even be layered in complexity - depth and the building up of layers and meaning are concepts that every archaeologist is familiar with after all! But there's one more reason why I think archaeology and the web should be embraced. The printed word lies at the very core of a discipline like history; archaeology, on the other hand, is made up of what we see (images, what we feel (experience, what we find (material, what we read (text - it is multimedia. So what better way to communicate all these things than in a like-minded medium?

  10. Understanding Current and Future Issues in Collaborative Consumption

    DEFF Research Database (Denmark)

    Barnes, Stuart; Mattsson, Jan


    Sharing activities underpinned by the technologies of the Internet have become dominant in the activities of individuals, business and governments. Recently, such sharing activity has grown from information and media content to wider resources, including money, physical goods and services — coined...... collaborative consumption. Sustainability is often cited as a key driver, underpinned by economic, social and environmental benefits. If successful, the sharing of such resources is likely to have a potentially disruptive impact on incumbents in traditional supply chains. However, given the embryonic state...

  11. Current issues in the understanding of consumer food choice

    DEFF Research Database (Denmark)

    Grunert, Klaus G.


    Consumer food choice is framed in terms of the formation of quality expectations before and quality experience after the purchase. For the formation of quality expectations, lack of consumer ability to form expectations that will be predictive of later experience is mentioned as a problem...... quality after the purchase, the role of home production - turning products into meals - is mentioned as important, but underresearced topic. Finally, differences in consumer behaviour between normal situations and situations of food crises are addressed. Udgivelsesdato: AUG...

  12. Feminist issues in development. (United States)

    Antrobus, P


    The United Nations Decade for the Advancement of Women, from 1975 to 1985, leaves a legacy of a deeper understanding of the issues, and the emergence of new networks with the experience and commitment to work for further changes. However, the role and status of women did not improve. There is a new commitment to struggle for the ending of all oppression, injustice and violence of all kinds at all levels. Feminism is a consciousness of all forms of women's oppression and a commitment to work against them. Feminist critiques illuminate the larger structures that oppress both women and men. New development theories embracing feminism are necessary to understand how patriarchy and economic systems propogate oppression. The production-oriented approach to rural development is flawed n failing to address women's lack of access to land, credit, training and new technologies. Overwhelming household tasks, cultural norms, and traditional attitudes limit women's involvement in training programs and other development activities. The basic needs approach to rural development provides access to vital services to meet a family's basic needs for nutrition, housing and clothing, and allows people's participation in decision making. However, women have little actual role in decision making so their needs, concerns and perspectives are not taken into account. Women are treated as instruments to achieve goals without appreciating their perspective. Project-based approached emphasize short term goals rather than laying the foundation for longterm changes. Few projects address structural issues or empower women. Projects must include education to increase personal growth and self reliance. Development planning can be enormously enhanced by taking gender differences into account and recognizing that people, specially poor women, can promote their own devleopment. Longterm strategies that challenge existing structures, address the existing economic order, and, most of all, recognize


    Directory of Open Access Journals (Sweden)



    Full Text Available The term “cloud computing” has been in the spotlights of IT specialists the last years because of its potential to transform this industry. The promised benefits have determined companies to invest great sums of money in researching and developing this domain and great steps have been made towards implementing this technology. Managers have traditionally viewed IT as difficult and expensive and the promise of cloud computing leads many to think that IT will now be easy and cheap. The reality is that cloud computing has simplified some technical aspects of building computer systems, but the myriad challenges facing IT environment still remain. Organizations which consider adopting cloud based services must also understand the many major problems of information policy, including issues of privacy, security, reliability, access, and regulation. The goal of this article is to identify the main security issues and to draw the attention of both decision makers and users to the potential risks of moving data into “the cloud”.

  14. Team dynamics in complex projects

    NARCIS (Netherlands)

    Oeij, P.; Vroome, E.E.M. de; Dhondt, S.; Gaspersz, J.B.R.


    Complexity of projects is hotly debated and a factor which affects innovativeness of team performance. Much attention in the past is paid to technical complexity and many issues are related to natural and physical sciences. A growing awareness of the importance of socioorganisational issues is

  15. Sustainable Sourcing of Global Agricultural Raw Materials: Assessing Gaps in Key Impact and Vulnerability Issues and Indicators.

    Directory of Open Access Journals (Sweden)

    Nathaniel P Springer

    Full Text Available Understanding how to source agricultural raw materials sustainably is challenging in today's globalized food system given the variety of issues to be considered and the multitude of suggested indicators for representing these issues. Furthermore, stakeholders in the global food system both impact these issues and are themselves vulnerable to these issues, an important duality that is often implied but not explicitly described. The attention given to these issues and conceptual frameworks varies greatly--depending largely on the stakeholder perspective--as does the set of indicators developed to measure them. To better structure these complex relationships and assess any gaps, we collate a comprehensive list of sustainability issues and a database of sustainability indicators to represent them. To assure a breadth of inclusion, the issues are pulled from the following three perspectives: major global sustainability assessments, sustainability communications from global food companies, and conceptual frameworks of sustainable livelihoods from academic publications. These terms are integrated across perspectives using a common vocabulary, classified by their relevance to impacts and vulnerabilities, and categorized into groups by economic, environmental, physical, human, social, and political characteristics. These issues are then associated with over 2,000 sustainability indicators gathered from existing sources. A gap analysis is then performed to determine if particular issues and issue groups are over or underrepresented. This process results in 44 "integrated" issues--24 impact issues and 36 vulnerability issues--that are composed of 318 "component" issues. The gap analysis shows that although every integrated issue is mentioned at least 40% of the time across perspectives, no issue is mentioned more than 70% of the time. A few issues infrequently mentioned across perspectives also have relatively few indicators available to fully represent

  16. Sustainable Sourcing of Global Agricultural Raw Materials: Assessing Gaps in Key Impact and Vulnerability Issues and Indicators. (United States)

    Springer, Nathaniel P; Garbach, Kelly; Guillozet, Kathleen; Haden, Van R; Hedao, Prashant; Hollander, Allan D; Huber, Patrick R; Ingersoll, Christina; Langner, Megan; Lipari, Genevieve; Mohammadi, Yaser; Musker, Ruthie; Piatto, Marina; Riggle, Courtney; Schweisguth, Melissa; Sin, Emily; Snider, Sara; Vidic, Nataša; White, Aubrey; Brodt, Sonja; Quinn, James F; Tomich, Thomas P


    Understanding how to source agricultural raw materials sustainably is challenging in today's globalized food system given the variety of issues to be considered and the multitude of suggested indicators for representing these issues. Furthermore, stakeholders in the global food system both impact these issues and are themselves vulnerable to these issues, an important duality that is often implied but not explicitly described. The attention given to these issues and conceptual frameworks varies greatly--depending largely on the stakeholder perspective--as does the set of indicators developed to measure them. To better structure these complex relationships and assess any gaps, we collate a comprehensive list of sustainability issues and a database of sustainability indicators to represent them. To assure a breadth of inclusion, the issues are pulled from the following three perspectives: major global sustainability assessments, sustainability communications from global food companies, and conceptual frameworks of sustainable livelihoods from academic publications. These terms are integrated across perspectives using a common vocabulary, classified by their relevance to impacts and vulnerabilities, and categorized into groups by economic, environmental, physical, human, social, and political characteristics. These issues are then associated with over 2,000 sustainability indicators gathered from existing sources. A gap analysis is then performed to determine if particular issues and issue groups are over or underrepresented. This process results in 44 "integrated" issues--24 impact issues and 36 vulnerability issues--that are composed of 318 "component" issues. The gap analysis shows that although every integrated issue is mentioned at least 40% of the time across perspectives, no issue is mentioned more than 70% of the time. A few issues infrequently mentioned across perspectives also have relatively few indicators available to fully represent them. Issues in the

  17. Understanding IT for Dispute Resolution

    Directory of Open Access Journals (Sweden)

    Dory Reiling


    Full Text Available Judges and judiciaries do not understand information technology (IT. This idea crops up quite often in discussions about IT for courts. The perceived slow rate of IT adoption in courts is explained by this lack of understanding. To my mind, this is not the main issue. What needs to be understood first is at the other end of the spectrum: how courts process information.

  18. Understanding DSGE models

    CERN Document Server

    Costa Junior, Celso Jose


    While the theoretical development of DSGE models is not overly difficult to understand, practical application remains somewhat complex. The literature on this subject has some significant obscure points. This book can be thought of, firstly, as a tool to overcome initial hurdles with this type of modeling. Secondly, by showcasing concrete applications, it aims to persuade incipient researchers to work with this methodology. In principle, this is not a book on macroeconomics in itself, but on tools used in the construction of this sort of models. It strives to present this technique in a detail

  19. Pedagogy of complex relationality exploring complexity theory, neuro-phenomenology, and attentiveness for education (United States)

    Khattar, Randa

    What do the new sciences of complex relationality offer education? This work draws on complexity theory, neurological understandings of biology and phenomenology, and attentiveness to study what the new sciences might offer education and the possibilities of a pedagogical understanding of embodied knowing. Complexity theory provides understandings of local-global relationality, self-organization, far-from-equilibrium conditions, and emergent dynamics that are important for describing pedagogical relationality. In itself, however, complexity theory is lacking an attention to issues of embodiment that respond directly to an ethical understanding of relationality. Phenomenology provides important views on the human experience of perception, for example, Merleau-Ponty's, whose research opens up possibilities for embodiment and attentiveness. At the level of pedagogical practice, I will pose, following biologists Humberto Maturana and Francisco Varela's autopoietic self-making understanding of life, that attentiveness perspectives, which have been largely absent from western pedagogical theory and practice, are crucial to promoting embodied knowing for education. Maturana and Varela's autopoietic perspective offers an embodied understanding of living---and therefore education---which opens up necessary attentive spaces to listen to one another in non judgmental awareness in the present moment of experience. I offer insights into a relationally complex conception of education drawing on this biological and autopoietically-grounded framework. These insights are framed in the context of five clusters of relations: (1) emergence, far-from-equilibrium, and local-global relationality; (2) autopoietic autonomy, structural determination and sensory-motor coupling; (3) triggering perturbations, structural plasticity, and autopoietic organization; (4) knowing as adequate action, domains of interaction, and blind spots; and (5) attentiveness and responsive relationality. Four

  20. Fabric quality issues related to apparel merchandising

    CSIR Research Space (South Africa)

    Das, Sonali


    Full Text Available The objectives of this study are to develop an understanding of fabric quality related issues and research gaps relevant to apparel manufacturing and merchandising within the South African context. The specific focus is on fabric objective...