WorldWideScience

Sample records for underlying disease died

  1. 9 CFR 325.20 - Transportation and other transactions concerning dead, dying, disabled, or diseased livestock...

    Science.gov (United States)

    2010-01-01

    ... concerning dead, dying, disabled, or diseased livestock, and parts of carcasses of livestock that died... other transactions concerning dead, dying, disabled, or diseased livestock, and parts of carcasses of livestock that died otherwise than by slaughter. No person engaged in the business of buying, selling, or...

  2. 9 CFR 309.3 - Dead, dying, disabled, or diseased and similar livestock.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Dead, dying, disabled, or diseased and... AND VOLUNTARY INSPECTION AND CERTIFICATION ANTE-MORTEM INSPECTION § 309.3 Dead, dying, disabled, or diseased and similar livestock. (a) Livestock found to be dead or in a dying condition on the premises of...

  3. 9 CFR 381.194 - Transportation and other transactions concerning dead, dying, disabled, or diseased poultry, and...

    Science.gov (United States)

    2010-01-01

    ... concerning dead, dying, disabled, or diseased poultry, and parts of carcasses of poultry that died otherwise... transactions concerning dead, dying, disabled, or diseased poultry, and parts of carcasses of poultry that died... commerce, or importing any dead, dying, disabled, or diseased poultry or parts of the carcasses of any...

  4. [Characterization of patients who died of invasive pneumococcal disease in the child population of Bogota, Colombia].

    Science.gov (United States)

    Rojas, Juan Pablo; Leal, Aura Lucia; Patiño, Jaime; Montañez, Anita; Camacho, Germán; Beltrán, Sandra; Bonilla, Carolina; Barrero, Rocio; Mariño, Cristina; Ramos, Nicolás

    2016-01-01

    Streptococcus pneumoniae (S. pneumoniae), also known as pneumococcus, is one of the main bacteria associated with mortality in children under 2 years of age, with a morbidity and mortality incidence that varies according to demographics and exposure to risk, or protective factors. To describe the child mortality due to invasive pneumococcal disease (IPD) between 2008 -2014 (6 years), in 8 Medical Centres in Bogotá, Colombia. Descriptive observational case series of patients who died of IPD, aged 28 days to 18 years, in 8 tertiary care institutions in Bogota, Colombia. The study period was from 1 January 2008 to 15 January 2014. 239 patients. A total of 239 registered cases of IPD were reviewed, showing a mortality of 8% (n 18). The mean age of patients that died was 43.7 months, with an age range from 2 to 176 months (14 years), with 66% of the cases being male. Serotypes were identified in 8 patients, finding: 6A, 6B, 10A, 14, 18C, 23B, 23F, and 35B. The most common clinical presentation of the cases was meningitis with mortality of 33% (6 cases), followed by bacteraemia without focus in 28% (5 cases), and pneumonia with 27% (5 cases). Combined clinical situations were presented, such as pneumonia and meningitis in 11% (2 cases). Two of the patients had clearly documented risk factors for IPD (asplenia and chronic respiratory disease). IPD mortality is particularly high in children under 2 years in male patients, especially when presented with a meningeal focus (44%). Serotyping was not possible in all patients who died, since no strain isolated was sent to the National Institute of Health. Continuous and systematic vigilance is required to evaluate the impact of vaccination and possible changes in the pattern of presentation of disease. Copyright © 2015 Sociedad Chilena de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

  5. Dying with motor neurone disease, what can we learn from family caregivers?

    Science.gov (United States)

    Ray, Robin A; Brown, Janice; Street, Annette F

    2014-08-01

    Increasingly, people with neurodegenerative illness are cared for at home until close to death. Yet, discussing the reality of dying remains a social taboo. To examine the ways, family caregivers of people living with motor neurone disease (MND) experienced the dying of their relative and to identify how health practitioners can better prepare families for end-of-life care. Secondary analysis was undertaken on data sets generated from two longitudinal qualitative studies employing similar data collection and analysis methods. Combining data sets increased participant numbers in a low incidence disease group. Primary studies were undertaken with family caregivers in England and Australia. Interview and observational data were collected mostly in home. Participants who discussed dying and death formed the sample for secondary analysis. Combined data revealed four major themes: planning for end of life, unexpected dying, dignity in the dying body and positive end to MND. Despite short survival predictions, discussions among family members about dying were often sporadic and linked to loss of hope. Effective planning for death assisted caregivers to manage the final degenerative processes of dying. When plans were not effectively communicated or enacted, capacity to preserve personhood was reduced. Returning death and dying to social discourse will raise the level of community awareness and normalize conversations about end-of-life care. Strategies for on-going, effective communication that facilitates advance care planning among patients, their families and practitioners are essential to improve dying and death for people with MND and their family caregivers. © 2012 John Wiley & Sons Ltd.

  6. Dying from cancer or other chronic diseases in the Netherlands: ten-year trends derived from death certificate data

    Directory of Open Access Journals (Sweden)

    Hingstman Lammert

    2009-02-01

    Full Text Available Abstract Background For the further development of palliative care, it is relevant to gain insight into trends in non-acute mortality. The aim of this article is twofold: (a to provide insight into ten-year trends in the characteristics of patients who died from cancer or other chronic diseases in the Netherlands; (b to show how national death statistics, derived from physicians' death certificates, can be used in this type of investigations. Methods Secondary analysis of data from 1996 to 2006 on the "primary" or "underlying" cause of death from official death certificates filled out by physicians and additional data from 2003 to 2006 on the place of death from these certificates. Results Of the 135,000 people who died in the Netherlands in 2006, 77,000 (or 57% died from a chronic disease. Cancer was the most frequent cause of death (40,000. Stroke accounted for 10,000 deaths, dementia for 8,000 deaths and COPD and heart failure each accounted for 6,000 deaths. Compared to 1996, the number of people who died from chronic diseases has risen by 6%. Of all non-acute deaths, almost three quarters were at least 70 years old when they died. Almost one third of the people died at home (31%, 28% in a hospital, 25% in a nursing home and 16% somewhere else. Conclusion Further investments to facilitate dying at home are desirable. Death certificate data proved to be useful to describe and monitor trends in non-acute deaths. Advantages of the use of death certificate data concern the reliability of the data, the opportunities for selection on the basis of the ICD-10, and the availability and low cost price of the data.

  7. The views of adults with Huntington's disease on assisted dying: A qualitative exploration.

    Science.gov (United States)

    Regan, Laurence; Preston, Nancy J; Eccles, Fiona J R; Simpson, Jane

    2018-04-01

    Assisted dying is frequently debated publicly and research often includes the views of health professionals on this issue. However, the views of people with life-limiting conditions, for whom this issue is likely to have a different resonance, are less well represented. The purpose of this study was to explore the views of people who live with the inevitability of developing Huntington's disease, a genetically transmitted disease which significantly limits life, on assisted dying. Using thematic analysis methodology, individual semi-structured interviews were conducted. Seven participants (five women and two men) who were gene positive for Huntington's disease took part in the study. Four themes were extracted: (1) autonomy and kindness in assisted dying: the importance of moral principles; (2) Huntington's disease threatens life and emphasises issues relating to death; (3) dilemmas in decision-making on assisted dying: "There are no winners" and (4) the absence of explicit discussion on dying and Huntington's disease: "Elephants in the room". Our findings suggest that talking to patients about assisted death may not cause harm and may even be invited by many patients with Huntington's disease. The perspectives of those who live with Huntington's disease, especially given its extended effects within families, add significant clinical and theoretical insights.

  8. The Investigations of Friction under Die Surface Vibration in Cold Forging Process

    DEFF Research Database (Denmark)

    Jinming, Sha

    of the application of ultrasonic vibration on drawing, rolling and other metal forming process show that the load and friction coefficient would be decreased with the presence of ultrasonic vibration. Investigations on forging processes and under low frequency, especially the quantitative analysis of friction......The objective of this thesis is to fundamentally study the influence of die surface vibration on friction under low frequency in metal forging processes. The research includes vibrating tool system design for metal forming, theoretical and experimental investigations, and finite element simulations...... on die surface vibration in forging process. After a general introduction to friction mechanisms and friction test techniques in metal forming, the application of ultrasonic vibration in metal forming, the influence of sliding velocity on friction is described. Some earlier investigations...

  9. 9 CFR 325.21 - Means of conveyance in which dead, dying, disabled, or diseased livestock and parts of carcasses...

    Science.gov (United States)

    2010-01-01

    ..., dying, disabled, or diseased livestock and parts of carcasses thereof shall be transported. 325.21... INSPECTION AND CERTIFICATION TRANSPORTATION § 325.21 Means of conveyance in which dead, dying, disabled, or... conveyance used by persons subject to § 325.20 for transporting in commerce or importing, any dead, dying...

  10. Dying piece by piece: carbohydrate dynamics in aspen (Populus tremuloides) seedlings under severe carbon stress.

    Science.gov (United States)

    Wiley, Erin; Hoch, Günter; Landhäusser, Simon M

    2017-11-02

    Carbon starvation as a mechanism of tree mortality is poorly understood. We exposed seedlings of aspen (Populus tremuloides) to complete darkness at 20 or 28 °C to identify minimum non-structural carbohydrate (NSC) concentrations at which trees die and to see if these levels vary between organs or with environmental conditions. We also first grew seedlings under different shade levels to determine if size affects survival time under darkness due to changes in initial NSC concentration and pool size and/or respiration rates. Darkness treatments caused a gradual dieback of tissues. Even after half the stem had died, substantial starch reserves were still present in the roots (1.3-3% dry weight), indicating limitations to carbohydrate remobilization and/or transport during starvation in the absence of water stress. Survival time decreased with increased temperature and with increasing initial shade level, which was associated with smaller biomass, higher respiration rates, and initially smaller NSC pool size. Dead tissues generally contained no starch, but sugar concentrations were substantially above zero and differed between organs (~2% in stems up to ~7.5% in leaves) and, at times, between temperature treatments and initial, pre-darkness shade treatments. Minimum root NSC concentrations were difficult to determine because dead roots quickly began to decompose, but we identify 5-6% sugar as a potential threshold for living roots. This variability may complicate efforts to identify critical NSC thresholds below which trees starve. © Society for Experimental Biology 2017.

  11. Assessment of the quality of life of patients with peripheral vascular diseases; Die Messung der gesundheitsbezogenen Lebensqualitaet bei der peripheren arteriellen Verschlusskrankheit

    Energy Technology Data Exchange (ETDEWEB)

    Wohlgemuth, W.A. [Klinikum Augsburg (Germany). Klinik fuer Diagnostische Radiologie und Neuroradiologie; Bayreuth Univ. (Germany). Inst. fuer Medizinmanagement und Gesundheitswissenschaften; Niechzial, M.; Nagel, E. [Bayreuth Univ. (Germany). Inst. fuer Medizinmanagement und Gesundheitswissenschaften; Bohndorf, K. [Klinikum Augsburg (Germany). Klinik fuer Diagnostische Radiologie und Neuroradiologie

    2003-02-01

    The Medical Outcome Short Form 36 is commonly used as a generic quality of life measure in the assessment of vascular disease. The Claudication Scale CLAU-S, the PAVK-86 Fragebogen, and the Walking Impairment Questionnaire WIQ are validated disease-specific questionnaires for intermittent claudication. A disease specific tool for critical ischaemia is lacking. Quality of life of patients with peripheral arterial occlusive disease is not only impaired in the physical functioning domains (mobility, self care, activities of daily living), but moreover in their social and emotional wellbeing. This situation worsens under conservative treatment. Angioplasty and operation procedure similar improvements in all dimensions of hrQOL. As radiological interventional procedures just aim to improve hrQOL and do not bring a definite cure for the underlying disease, patients perception of their quality of life should be taken into account both in the indication for angioplasty and for the scientific evaluation of new treatment modalities. (orig.) [German] Mit dem sog. Short-Form 36 (SF-36) existiert bei der peripheren arteriellen Verschlusskrankheit (pAVK) ein anerkanntes mehrdimensionales Messinstrument der Lebensqualitaet ergaenzt durch drei validierte krankheitsspezifische Messinstrumente (Claudication Scale CLAU-S, Fragebogen PAVK-86, Walking Impairment Questionnaire WIQ), die die krankheisspezifischen Probleme der Claudicatio intermittens untersuchen. Ein krankheitsspezifisches Messinstrument fuer die kritische Ischaemie fehlt bisher. Schaetzen pAVK-Patienten ihre Lebensqualitaet selbst ein, so fuehlen sie diese nicht nur aufgrund reduzierter koerperlicher Funktionen (Mobilitaetseinschraenkungen, haeusliche Verrichtungen, Koerperpflege u.a.) und Schmerzen beeintraechtigt. Auch Schlaf, soziales und emotionales Wohlbefinden (Aengstlichkeit, Antriebsschwaeche) sind stark mitbetroffen. Alle Ergebnisse deuten darauf hin, dass sich die Lebensqualitaet bei der pAVK unter einer

  12. Die Bonding Performance Using Bimodal Cu Particle Paste Under Different Sintering Atmospheres

    Science.gov (United States)

    Gao, Yue; Zhang, Hao; Li, Wanli; Jiu, Jinting; Nagao, Shijo; Sugahara, Tohru; Suganuma, Katsuaki

    2017-07-01

    A one-step polyol method was employed to synthesize bimodal Cu particles with average diameters around 200 nm and 1000 nm, respectively. The bimodal Cu particles were mixed with a reductive solvent of polyethylene glycol (PEG) to form a paste. The Cu paste was used as die bonding material to prepare Cu joints under N2 or vacuum sintering atmosphere. The results showed that the strength of the Cu joints in N2 atmosphere was always higher than that in vacuum. The shear strength of a Cu joint processed at 350°C under only 0.4 MPa bonding pressure in N2 was above 40 MPa, which was far higher than that obtained using single-sized nano-Cu particle paste. It is related to the dense packing of the bimodal Cu particles and slow decomposition behavior of the reductive PEG solvent. The reductive PEG solvent in the Cu paste, which effectively removed oxides on the surface of the Cu particles, was necessary for easy-oxidized Cu pastes. These results suggested that Cu pastes with suitable particle sizes, reducing solvent and sintering atmosphere could be a proper candidate for low-temperature and low-pressure bonding process.

  13. Where do children die and what are the causes? Under-5 deaths in ...

    African Journals Online (AJOL)

    to Clinicom. Of the children 384 (55%) therefore appeared to have died outside a hospital or nursing home. The median age of these children was 92 days (IQR 37.5 - 338);. 211 (55%) were male and 173 (45%) female. Table 4 shows a comparison of the leading causes of death in children who died in and out of hospital by ...

  14. 26 CFR 20.2039-3 - Lump sum distributions under “qualified plans;” decedents dying after December 31, 1976, and...

    Science.gov (United States)

    2010-04-01

    ... decedents dying after December 31, 1976, and before January 1, 1979. 20.2039-3 Section 20.2039-3 Internal...; ESTATES OF DECEDENTS DYING AFTER AUGUST 16, 1954 Gross Estate § 20.2039-3 Lump sum distributions under “qualified plans;” decedents dying after December 31, 1976, and before January 1, 1979. (a) Limitation of...

  15. 26 CFR 20.2204-3 - Special rules for estates of decedents dying after December 31, 1976; special lien under section...

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 14 2010-04-01 2010-04-01 false Special rules for estates of decedents dying... OF DECEDENTS DYING AFTER AUGUST 16, 1954 Miscellaneous § 20.2204-3 Special rules for estates of decedents dying after December 31, 1976; special lien under section 6324A. For purposes of §§ 20.2204-1(b...

  16. Epigenetic alterations underlying autoimmune diseases.

    Science.gov (United States)

    Aslani, Saeed; Mahmoudi, Mahdi; Karami, Jafar; Jamshidi, Ahmad Reza; Malekshahi, Zahra; Nicknam, Mohammad Hossein

    2016-01-01

    Recent breakthroughs in genetic explorations have extended our understanding through discovery of genetic patterns subjected to autoimmune diseases (AID). Genetics, on the contrary, has not answered all the conundrums to describe a comprehensive explanation of causal mechanisms of disease etiopathology with regard to the function of environment, sex, or aging. The other side of the coin, epigenetics which is defined by gene manifestation modification without DNA sequence alteration, reportedly has come in to provide new insights towards disease apprehension through bridging the genetics and environmental factors. New investigations in genetic and environmental contributing factors for autoimmunity provide new explanation whereby the interactions between genetic elements and epigenetic modifications signed by environmental agents may be responsible for autoimmune disease initiation and perpetuation. It is aimed through this article to review recent progress attempting to reveal how epigenetics associates with the pathogenesis of autoimmune diseases.

  17. Characterization of metal powder based rapid prototyping components under aluminium high pressure die casting process conditions

    CSIR Research Space (South Africa)

    Pereira, MFVT

    2009-11-01

    Full Text Available This paper is based on tests performed on die component specimens grown on an EOS RP technology platform, as well as manufactured specimens machined out of preferred standard hot work steel DIN 1.2344. These specimens resemble typical components...

  18. Effect of triangular texture on the tribological performance of die steel with TiN coatings under lubricated sliding condition

    Science.gov (United States)

    Chen, Ping; Xiang, Xin; Shao, Tianmin; La, Yingqian; Li, Junling

    2016-12-01

    The friction and wear of stamping die surface can affect the service life of stamping die and the quality of stamping products. Surface texturing and surface coating have been widely used to improve the tribological performance of mechanical components. This study experimentally investigated the effect of triangular surface texture on the friction and wear properties of the die steel substrate with TiN coatings under oil lubrication. TiN coatings were deposited on a die steel (50Cr) substrate through a multi-arc ion deposition system, and then triangular surface texturing was fabricated by a laser surface texturing. The friction and wear test was conducted by a UMT-3 pin-on-disk tribometer under different sliding speeds and different applied loads, respectively. The adhesion test was performed to evaluate the effectiveness of triangular texturing on the interfacial bonding strength between the TiN coating and the die steel substrate. Results show that the combination method of surface texturing process and surface coating process has excellent tribological properties (the lowest frictional coefficient and wear volume), compared with the single texturing process or the single coating process. The tribological performance is improved resulting from the high hardness and low elastic modulus of TiN coatings, and the generation of hydrodynamic pressure, function of micro-trap for wear debris and micro-reservoirs for lubricating oil of the triangular surface texture. In addition, the coating bonding strength of the texturing sample is 3.63 MPa, higher than that of the single coating sample (3.48 MPa), but the mechanisms remain to be further researched.

  19. Die wese van die geloof.

    Directory of Open Access Journals (Sweden)

    P. J. S. De Klerk

    1957-03-01

    Full Text Available Waar ons op 31 Oktober weer dink aan die werk van die Hervorining, daar is dit nodig dat ons weer die aandag vestig op die geloofsworsteling van die manne van die Hervorming. Om daardie geloofsworsteling te verstaan is dit nodig om te let op die wese van die geloof.En om die wese van die geloof te verstaan is dit nodig om eers te let op die geloofsopvatting van Rome.

  20. Chronic Venous Disease under pressure

    NARCIS (Netherlands)

    S.W.I. Reeder (Suzan)

    2013-01-01

    textabstractIn chapter 1 we provide a general introduction of this thesis. Chronic venous disease (CVD) is a common medical condition that affects 2-64% of the worldwide population and leads to leg ulcers in 1% of the Western population. Venous leg ulceration (VLU) has an unfavorable prognosis with

  1. Epiphytic lichen diversity on dead and dying conifers under different levels of atmospheric pollution

    Energy Technology Data Exchange (ETDEWEB)

    Hauck, Markus [Albrecht von Haller Institute of Plant Sciences, University of Goettingen, Untere Karspuele 2, D-37073 Goettingen (Germany)]. E-mail: mhauck@gwdg.de

    2005-05-01

    Based on literature data, epiphytic lichen abundance was comparably studied in montane woodlands on healthy versus dead or dying conifers of Europe and North America in areas with different levels of atmospheric pollution. Study sites comprised Picea abies forests in the Harz Mountains and in the northern Alps, Germany, Picea rubens-Abies balsamea forests on Whiteface Mountain, Adirondacks, New York, U.S.A. and Picea engelmannii-Abies lasiocarpa forests in the Salish Mountains, Montana, U.S.A. Detrended correspondence analysis showed that epiphytic lichen vegetation differed more between healthy and dead or dying trees at high- versus low-polluted sites. This is attributed to greater differences in chemical habitat conditions between trees of different vitality in highly polluted areas. Based on these results, a hypothetical model of relative importance of site factors for small-scale variation of epiphytic lichen abundance versus atmospheric pollutant load is discussed. - Epiphytic lichen diversity differs increasingly between healthy and dead or dying conifers with increasing atmospheric pollutant load.

  2. Epiphytic lichen diversity on dead and dying conifers under different levels of atmospheric pollution

    International Nuclear Information System (INIS)

    Hauck, Markus

    2005-01-01

    Based on literature data, epiphytic lichen abundance was comparably studied in montane woodlands on healthy versus dead or dying conifers of Europe and North America in areas with different levels of atmospheric pollution. Study sites comprised Picea abies forests in the Harz Mountains and in the northern Alps, Germany, Picea rubens-Abies balsamea forests on Whiteface Mountain, Adirondacks, New York, U.S.A. and Picea engelmannii-Abies lasiocarpa forests in the Salish Mountains, Montana, U.S.A. Detrended correspondence analysis showed that epiphytic lichen vegetation differed more between healthy and dead or dying trees at high- versus low-polluted sites. This is attributed to greater differences in chemical habitat conditions between trees of different vitality in highly polluted areas. Based on these results, a hypothetical model of relative importance of site factors for small-scale variation of epiphytic lichen abundance versus atmospheric pollutant load is discussed. - Epiphytic lichen diversity differs increasingly between healthy and dead or dying conifers with increasing atmospheric pollutant load

  3. DIE PERSOON VAN VREDE IN DIE SENDING

    African Journals Online (AJOL)

    aan dat 'n lewe onder die gesag van God tot volle vrede lei: “In coming under the rule of Yahweh, moreover, life was made whole and safe.” Dit is spesifiek in die tempel waar die volheid van God se vrede ondervind word (1997:662):. The temple is indeed the place where Israel entered into Yahweh's full zone of shalom.

  4. 20 CFR 10.113 - What should the employer do when an employee dies from a work-related injury or disease?

    Science.gov (United States)

    2010-04-01

    ... dies from a work-related injury or disease? 10.113 Section 10.113 Employees' Benefits OFFICE OF WORKERS... Notices and Claims for Injury, Disease, and Death-Employer's Actions § 10.113 What should the employer do when an employee dies from a work-related injury or disease? (a) The employer shall immediately report...

  5. Die instelling van die doop

    Directory of Open Access Journals (Sweden)

    J. L. Venter

    1989-05-01

    Full Text Available Die eerste plek in die evangeliebeskrywings waar daar van die doop as ’n opdrag van Jesus Christus gepraat word en waar die betekenis die duidelikste uitkristalliseer, staan in Matteus 28 : 16 - 20. Heilshistories gesien, is dit die begin van kerklike inlywing van die wat gehoor het hoedat Jesus sy koninkryk proklameer, die evangelie aanvaar en tot bekering kom. Vir die doel van hierdie artikel word hierdie gedeelte ondersoek om te sien hoe die instelling geskied het, wat die plek en betekenis van die Christelike doop is.

  6. Die Region braucht die Kultur - die Kultur braucht die Region

    OpenAIRE

    Klemm, Ulrich

    1995-01-01

    Die Region braucht die Kultur - die Kultur braucht die Region. - In: Region in Aktion - oder: Region im Abseits? - Boxberg-Wölchingen : Eigenständige Regionalentwicklung Baden-Württemberg, 1995. - S. 25 f.

  7. Die sideboard

    African Journals Online (AJOL)

    Owner

    man wat vir die De Bruins werk en Stella. Figland, 'n onderwyseres en Abraham se latere vrou. Abraham is op die punt om die grond waarop hulle boer, te koop wanneer die groot slag kom. In afwagting van die nuwe plant- seisoen word hierdie pastorale gemoedelik- heid waar Miena die Venters se eerste kleinkind.

  8. "Perhaps I will die young." Fears and worries regarding disease and death among Danish adolescents and young adults with cancer

    DEFF Research Database (Denmark)

    Hølge-Hazelton, Bibi; Timm, Helle U.; Graugaard, Christian

    2016-01-01

    about dying; (Q2) with whom, if anyone, they had shared those worries; and finally, (Q3) how fears and worries influenced their daily life. The emphasis will be on Q3. Methods: A 151-item questionnaire (including two closed- and one open-ended questions about fears of death and dying) was distributed...... worries about death; hereof, more than half of them expressed quite a bit or very much. The analysis showed significant gender differences, whereas age and duration of disease did not have any significant impact on such thoughts. Q2: One third had not talked to anybody about his or her worries. Q3......: The analysis resulted in three overall categories: fear of disease and death having little or no influence (n = 100), fear influencing in various ways (n = 215), and fear of disease and death having a substantial influence (n = 75). Conclusions: The majority of AYAs had experienced fears and worries about...

  9. Die nabyheid van die Koninkryk

    Directory of Open Access Journals (Sweden)

    W.J. Snyman

    1963-03-01

    Full Text Available Vanweë die belangrikheid daarvan volg hier ’n breër bespreking van die proefskrif van dr. Tjaart van der Walt oor die nabyheid van die Koninkryk as wat in ’n gewone resensie kan geskied. Die vraagstuk wat onder oë gesien word is so oud as die kerk en die teologie, soms minder en soms meer op die voorgrond. Tans kan gesê word, staan dit in die middelpunt. Daarby is dit nie maar ’n akademiese vraagstuk nie, maar ’n vraagstuk waarvoor elke nadenkende leser van die Skrif te staan kom.

  10. The 'dis-ease' of dying: challenges in nursing care of the dying in the acute hospital setting. A qualitative observational study.

    Science.gov (United States)

    Bloomer, Melissa J; Endacott, Ruth; O'Connor, Margaret; Cross, Wendy

    2013-09-01

    Changes in health care and an ageing population have meant that more people are dying in the acute hospital setting. While palliative care principles have resulted in quality care for the dying, many patients die in an acute care, still receiving aggressive/resuscitative care. The aims were to explore nurses' 'recognition of' and 'responsiveness to' dying patients and to understand the nurses' influence on end-of-life care. A qualitative approach was taken utilising non-participant observation to elicit rich data, followed by focus groups and individual semi-structured interviews for clarification. This study was conducted in two acute medical wards in one health service, identified as having the highest rates of death, once palliative care and critical care areas were excluded. Twenty-five nurses consented to participate, and 20 episodes of observation were conducted. Nurses took a passive role in recognising dying, providing active care until a medical officer's declaration of dying. Ward design, nurse allocation and nurses' attitude to death impacts patient care. End-of-life care in a single room can have negative consequences for the dying. Nurses demonstrated varying degrees of discomfort, indicating that they were underprepared for this role. When patients are terminally ill, acknowledgement of dying is essential in providing appropriate care. It should not be assumed that all nurses are adequately prepared to provide dying care. Further work is necessary to investigate how the attitudes of nurses towards caring for dying patients in the acute hospital setting may impact care of the dying patient.

  11. Die aktualisering van die gemeenskap van die gelowiges binne die ...

    African Journals Online (AJOL)

    The youth experiences the pubHc service in the Neder- duitsch Hervormde Church of Africa as cold and dead. ... the public service, and the actualising of the believers. 1. RELEVANSIE VAN DIE TEMA ..... die erediens lean inrig sodat die volledige implikasie en appél van die Goddelike, vertikale indikatief na die horisontale ...

  12. Die topkwark

    Directory of Open Access Journals (Sweden)

    R. Tegen

    1998-07-01

    Full Text Available ’n Oorsig van die belangrikheid van die onlangs ontdekte topkwark by Fermilab in Chicago word gegee. Daar word aangetnon dat die topkwark belangrik is in fisika van die Oerknal, oftewel "Big Bang", en in die Standaard Model van Elementêredeeltjie-fisika. Toepaslike literatuur vir verdere studie kan van die lys van verwysings in hierdie kort, nietegniese artikel, nagegaan word.

  13. Contact Behavior of Composite CrTiSiN Coated Dies in Compressing of Mg Alloy Sheets under High Pressure

    Directory of Open Access Journals (Sweden)

    T.S. Yang

    2018-01-01

    Full Text Available Hard coatings have been adopted in cutting and forming applications for nearly two decades. The major purpose of using hard coatings is to reduce the friction coefficient between contact surfaces, to increase strength, toughness and anti-wear performance of working tools and molds, and then to obtain a smooth work surface and an increase in service life of tools and molds. In this report, we deposited a composite CrTiSiN hard coating, and a traditional single-layered TiAlN coating as a reference. Then, the coatings were comparatively studied by a series of tests. A field emission SEM was used to characterize the microstructure. Hardness was measured using a nano-indentation tester. Adhesion of coatings was evaluated using a Rockwell C hardness indentation tester. A pin-on-disk wear tester with WC balls as sliding counterparts was used to determine the wear properties. A self-designed compression and friction tester, by combining a Universal Testing Machine and a wear tester, was used to evaluate the contact behavior of composite CrTiSiN coated dies in compressing of Mg alloy sheets under high pressure. The results indicated that the hardness of composite CrTiSiN coating was lower than that of the TiAlN coating. However, the CrTiSiN coating showed better anti-wear performance. The CrTiSiN coated dies achieved smooth surfaces on the Mg alloy sheet in the compressing test and lower friction coefficient in the friction test, as compared with the TiAlN coating.

  14. Contact Behavior of Composite CrTiSiN Coated Dies in Compressing of Mg Alloy Sheets under High Pressure.

    Science.gov (United States)

    Yang, T S; Yao, S H; Chang, Y Y; Deng, J H

    2018-01-08

    Hard coatings have been adopted in cutting and forming applications for nearly two decades. The major purpose of using hard coatings is to reduce the friction coefficient between contact surfaces, to increase strength, toughness and anti-wear performance of working tools and molds, and then to obtain a smooth work surface and an increase in service life of tools and molds. In this report, we deposited a composite CrTiSiN hard coating, and a traditional single-layered TiAlN coating as a reference. Then, the coatings were comparatively studied by a series of tests. A field emission SEM was used to characterize the microstructure. Hardness was measured using a nano-indentation tester. Adhesion of coatings was evaluated using a Rockwell C hardness indentation tester. A pin-on-disk wear tester with WC balls as sliding counterparts was used to determine the wear properties. A self-designed compression and friction tester, by combining a Universal Testing Machine and a wear tester, was used to evaluate the contact behavior of composite CrTiSiN coated dies in compressing of Mg alloy sheets under high pressure. The results indicated that the hardness of composite CrTiSiN coating was lower than that of the TiAlN coating. However, the CrTiSiN coating showed better anti-wear performance. The CrTiSiN coated dies achieved smooth surfaces on the Mg alloy sheet in the compressing test and lower friction coefficient in the friction test, as compared with the TiAlN coating.

  15. Isaac Albeniz (1860-1909): Spanish musician who died of chronic renal disease.

    Science.gov (United States)

    García-Nieto, Víctor M; Peralta-Aros, Carolina

    2013-02-01

    Isaac Albéniz was a Spanish musician and pianist who was best known in France and England. One of his last works for piano, the suite Iberia, is well-known and identifies his country of origin. He died with terminal uraemia following longstanding chronic intestinal and kidney symptoms. Suggestions as to pathology include amyloidosis complicated by kidney stones and hypertension that sometimes manifested itself in the form of hypertensive crisis, accompanied by obesity.

  16. Effect of noise on human performance under variable load in a die casting industry--a case study.

    Science.gov (United States)

    Muzammil, M; Khan, Abid A; Hasan, F; Hasan, S N

    2004-01-01

    The manual mode of working in industries is very common in the developing and under developed countries. Many industrial processes have generated high levels of noise and causing physiological effects on operators and thus leading to reduced performance. A survey was carried in various die casting industries to determine the levels of noise. It was found that the levels were in the range of 80-100dB(A). The survey also showed that the effects were more pronounced when the task was conducted under varying load conditions. Keeping this in view the problem was formulated to study whether the level of noise and amount of load has a bearing on human performance. For this purpose, experimental investigations in a simulated environment were carried out. Five subjects, all males and having no experience in the trade were selected for the task. The levels of noise under taken were 80, 90 and 100 dB(A) while the levels of load were 150, 200 and 250 N. A pulse oximeter was used to measure the human performance in terms of heart rate. The data was collected and analyzed on the basis of two factor repeated measure type of experimental design. Results of the study indicated that the level of noise and load both were having statistically significant effect on human performance. However, the interaction of level of noise and load was found to be statistically non-significant. The findings of the present work have been discussed in the light of the previous researches carried out on the topic. Suggestions have been made to reduce the levels of noise as per the recommendations of Occupational Safety and Health Association (1990). It is also suggested that instead of hand operated machines, foot operated versions should be used to reduce fatigue.

  17. Alloimmunization in multitransfused liver disease patients: Impact of underlying disease

    Directory of Open Access Journals (Sweden)

    Meenu Bajpai

    2016-01-01

    Full Text Available Introduction: Transfusion support is vital to the management of patients with liver diseases. Repeated transfusions are associated with many risks such as transfusion-transmitted infection, transfusion immunomodulation, and alloimmunization. Materials and Methods: A retrospective data analysis of antibody screening and identification was done from February 2012 to February 2014 to determine the frequency and specificity of irregular red-cell antibodies in multitransfused liver disease patients. The clinical and transfusion records were reviewed. The data was compiled, statistically analyzed, and reviewed. Results: A total of 842 patients were included in our study. Alloantibodies were detected in 5.22% of the patients. Higher rates of alloimmunization were seen in patients with autoimmune hepatitis, cryptogenic liver disease, liver damage due to drugs/toxins, and liver cancer patients. Patients with alcoholic liver disease had a lower rate of alloimmunization. The alloimmunization was 12.7% (23/181 in females and 3.17% (21/661 in males. Antibodies against the Rh system were the most frequent with 27 of 44 alloantibodies (61.36%. The most common alloantibody identified was anti-E (11/44 cases, 25%, followed by anti-C (6/44 cases, 13.63%. Conclusion: Our findings suggest that alloimmunization rate is affected by underlying disease. Provision of Rh and Kell phenotype-matched blood can significantly reduce alloimmunization.

  18. Die belangrikste kenmerk van die diereproduksie- bedrywe oor die ...

    African Journals Online (AJOL)

    Die belangrikste kenmerk van die diereproduksie- bedrywe oor die afgelope paar dekades was die neiging tot die reorganisasie van die produksiestelsels. Hoewel dit die verste gevorder het in die geval van pluimvee-, vark· en beesproduksiestelsels is daar by die tradisioneel eksten- siewe skaapbedryf ook duidelike ...

  19. die rol van die unieverdedigingsmag in die onderdrukking van die ...

    African Journals Online (AJOL)

    reik, terwyl ander weer te min kampeeruitrusting ontvang het. In sommige gebiede moes heelwat voorrade ook inderhaas uit plaaslike bronne aangevul word. Daar is ook gevind dat daar nie genoeg gewere in die Unie beskikbaar was nie. Gevolglik is daar reelings met die Britse regering getref vir die verskaffing daarvan.

  20. Die funksie van die belydenis in die struktuur van die kerk en die ...

    African Journals Online (AJOL)

    Ter wille van die argument wat in hierdie voordrag na vore gebring word, word vier sodanige konstituerende elemente van die kerklike struktuur onderskei, te wete die belydenis, die teologie, die verkondi- ging (meer bepaald die prediking) en die kerkorde (kerkwet volgens ons terminologie). Ons gaan nou elkeen hiervan ...

  1. Pet Ownership and the Risk of Dying from Cardiovascular Disease Among Adults Without Major Chronic Medical Conditions.

    Science.gov (United States)

    Ogechi, Imala; Snook, Kassandra; Davis, Bionca M; Hansen, Andrew R; Liu, Fengqi; Zhang, Jian

    2016-09-01

    In a recent statement, the American Heart Association stated "There are scant data on pet ownership and survival in people without established cardiovascular disease (CVD)". This study sought to fill this gap. We analyzed nationally representative data of 3964 adults aged ≥50 who were free from major physical illnesses. Pet ownership was assessed at baseline between 1988 and 1994. Vital status was followed through December 31st 2006. With dogs being most popular pets owned by 22.0 (standard error 0.34) % of the participants, 34.6 % of the study population owned a pet. Pet ownership was associated with low rates of CVD deaths [hazard ratio (HR) = 0.69 (95 % CI 0.45-1.07)] and stroke [0.54 (0.28-1.01)] at borderline significant levels among women. These associations were adjusted for physical activity and largely attributed to having a cat rather than a dog. Among cat owners, the HR of all CVD deaths was 0.62 (0.36-1.05) and the HR of dying from stroke was 0.22 (0.07-0.68) compared with non-cat owners. The corresponding HRs among dog owners were 0.82 (0.51-1.34) and 0.76 (0.34-1.71) respectively. No similar associations were observed among men. The hazard of dying from hypertension was not associated with pet ownership for both men and women. Owning a cat rather than a dog was significantly associated with a reduced hazard of dying from CVD events, in particular, stroke. The protection pets confer may not be from physical activities, but possibly due to personality of the pet owners or stress-relieving effects of animal companionship.

  2. Die Elementarkonstanten und die Mathematik

    Science.gov (United States)

    Rompe, Robert; Treder, Hans-Jürgen

    Die Elementarkonstanten im Sinne von Max Planck sind von ähnlicher Bedeutung wie die reinen Zahlen der Mathematik. Die Newtonschen Prinzipien und die Elementarkonstanten zusammen sind der Grundbau der physikalischen Theoriebildung.Translated AbstractThe Elementary Constants and the MathematicThe elementary constants in the sense of Max Planck are of analogous meaning as the pure numbers in mathematics. The Newtonian principles together with the elementary constants are the basis for creating physical theories.

  3. Die teologie in gesprek met die ekonomie

    African Journals Online (AJOL)

    diktaat van die regte rede' is en John Locke (1632-1704), wie se rasionalisering van die samelewing die beste daarin slaag om uitdrukking te gee aan die wese van die opkomende Britse liberalisme van die sewentiende eeu. 2^ 'n Samelewing waarin die ekonomie die bepalende posisie inneem. Die samelewing wat ...

  4. DIE GEESTESSTRUKTUUR VAN DIE ONGELOOF In die studie van ...

    African Journals Online (AJOL)

    Test

    BACON (1561-1626), oor die algemeen erken as die vader van die empirisme, het met sy idole-leer 'n geweldige invloed uitgeoefen. Die idole-leer neem aan dat die werklikheid deur die mens se verstand geken kan word en wel op grond van die natuurlike vermoë van die verstand. Daar is egter allerlei hindernisse in ons ...

  5. Die posisie van die Helper in die sending

    Directory of Open Access Journals (Sweden)

    I. J. van der Walt

    1972-05-01

    Full Text Available Gedurende die aanvangsjare van die sending het die helper ’n onmisbare funksie vervul. Hulle het die onherbergsame binnelande geken, waardevolle kontakpunte vir die sendelinge geopen en hulle mense geestelik help voorlig en voorberei.

  6. Drought's legacy: multiyear hydraulic deterioration underlies widespread aspen forest die-off and portends increased future risk.

    Science.gov (United States)

    Anderegg, William R L; Plavcová, Lenka; Anderegg, Leander D L; Hacke, Uwe G; Berry, Joseph A; Field, Christopher B

    2013-04-01

    Forest mortality constitutes a major uncertainty in projections of climate impacts on terrestrial ecosystems and carbon-cycle feedbacks. Recent drought-induced, widespread forest die-offs highlight that climate change could accelerate forest mortality with its diverse and potentially severe consequences for the global carbon cycle, ecosystem services, and biodiversity. How trees die during drought over multiple years remains largely unknown and precludes mechanistic modeling and prediction of forest die-off with climate change. Here, we examine the physiological basis of a recent multiyear widespread die-off of trembling aspen (Populus tremuloides) across much of western North America. Using observations from both native trees while they are dying and a rainfall exclusion experiment on mature trees, we measure hydraulic performance over multiple seasons and years and assess pathways of accumulated hydraulic damage. We test whether accumulated hydraulic damage can predict the probability of tree survival over 2 years. We find that hydraulic damage persisted and increased in dying trees over multiple years and exhibited few signs of repair. This accumulated hydraulic deterioration is largely mediated by increased vulnerability to cavitation, a process known as cavitation fatigue. Furthermore, this hydraulic damage predicts the probability of interyear stem mortality. Contrary to the expectation that surviving trees have weathered severe drought, the hydraulic deterioration demonstrated here reveals that surviving regions of these forests are actually more vulnerable to future droughts due to accumulated xylem damage. As the most widespread tree species in North America, increasing vulnerability to drought in these forests has important ramifications for ecosystem stability, biodiversity, and ecosystem carbon balance. Our results provide a foundation for incorporating accumulated drought impacts into climate-vegetation models. Finally, our findings highlight the

  7. Unfertilized Xenopus eggs die by Bad-dependent apoptosis under the control of Cdk1 and JNK.

    Directory of Open Access Journals (Sweden)

    David Du Pasquier

    Full Text Available Ovulated eggs possess maternal apoptotic execution machinery that is inhibited for a limited time. The fertilized eggs switch off this time bomb whereas aged unfertilized eggs and parthenogenetically activated eggs fail to stop the timer and die. To investigate the nature of the molecular clock that triggers the egg decision of committing suicide, we introduce here Xenopus eggs as an in vivo system for studying the death of unfertilized eggs. We report that after ovulation, a number of eggs remains in the female body where they die by apoptosis. Similarly, ovulated unfertilized eggs recovered in the external medium die within 72 h. We showed that the death process depends on both cytochrome c release and caspase activation. The apoptotic machinery is turned on during meiotic maturation, before fertilization. The death pathway is independent of ERK but relies on activating Bad phosphorylation through the control of both kinases Cdk1 and JNK. In conclusion, the default fate of an unfertilized Xenopus egg is to die by a mitochondrial dependent apoptosis activated during meiotic maturation.

  8. Verbal autopsy as a tool for identifying children dying of sickle cell disease: a validation study conducted in Kilifi district, Kenya

    Science.gov (United States)

    2014-01-01

    Background Sickle cell disease (SCD) is common in many parts of sub-Saharan Africa (SSA), where it is associated with high early mortality. In the absence of newborn screening, most deaths among children with SCD go unrecognized and unrecorded. As a result, SCD does not receive the attention it deserves as a leading cause of death among children in SSA. In the current study, we explored the potential utility of verbal autopsy (VA) as a tool for attributing underlying cause of death (COD) in children to SCD. Methods We used the 2007 WHO Sample Vital Registration with Verbal Autopsy (SAVVY) VA tool to determine COD among child residents of the Kilifi Health and Demographic Surveillance System (KHDSS), Kenya, who died between January 2008 and April 2011. VAs were coded both by physician review (physician coded verbal autopsy, PCVA) using COD categories based on the WHO International Classification of Diseases 10th Edition (ICD-10) and by using the InterVA-4 probabilistic model after extracting data according to the 2012 WHO VA standard. Both of these methods were validated against one of two gold standards: hospital ICD-10 physician-assigned COD for children who died in Kilifi District Hospital (KDH) and, where available, laboratory confirmed SCD status for those who died in the community. Results Overall, 6% and 5% of deaths were attributed to SCD on the basis of PCVA and the InterVA-4 model, respectively. Of the total deaths, 22% occurred in hospital, where the agreement coefficient (AC1) for SCD between PCVA and hospital physician diagnosis was 95.5%, and agreement between InterVA-4 and hospital physician diagnosis was 96.9%. Confirmatory laboratory evidence of SCD status was available for 15% of deaths, in which the AC1 against PCVA was 87.5%. Conclusions Other recent studies and provisional data from this study, outlining the importance of SCD as a cause of death in children in many parts of the developing world, contributed to the inclusion of specific SCD

  9. die rol van die eerste suid- afrikaanse infanteriedivisie tydens die ...

    African Journals Online (AJOL)

    Teen die einde van Julie 1942 het 'n tydelike skaakmatsituasie in die oorlog in Noord-Afrika ontstaan. Genl. C.J.E.. Auchinleck, gesamentlik in bevel van die Britsemagte in die Midde Ooste en die 8ste Leer in Egipte, het laasge- noemde by EIAlamein tot die verde- diging loot oorgaan en die oppo- nerende magte het begin ...

  10. Neural correlates underlying micrographia in Parkinson's disease.

    Science.gov (United States)

    Wu, Tao; Zhang, Jiarong; Hallett, Mark; Feng, Tao; Hou, Yanan; Chan, Piu

    2016-01-01

    Micrographia is a common symptom in Parkinson's disease, which manifests as either a consistent or progressive reduction in the size of handwriting or both. Neural correlates underlying micrographia remain unclear. We used functional magnetic resonance imaging to investigate micrographia-related neural activity and connectivity modulations. In addition, the effect of attention and dopaminergic administration on micrographia was examined. We found that consistent micrographia was associated with decreased activity and connectivity in the basal ganglia motor circuit; while progressive micrographia was related to the dysfunction of basal ganglia motor circuit together with disconnections between the rostral supplementary motor area, rostral cingulate motor area and cerebellum. Attention significantly improved both consistent and progressive micrographia, accompanied by recruitment of anterior putamen and dorsolateral prefrontal cortex. Levodopa improved consistent micrographia accompanied by increased activity and connectivity in the basal ganglia motor circuit, but had no effect on progressive micrographia. Our findings suggest that consistent micrographia is related to dysfunction of the basal ganglia motor circuit; while dysfunction of the basal ganglia motor circuit and disconnection between the rostral supplementary motor area, rostral cingulate motor area and cerebellum likely contributes to progressive micrographia. Attention improves both types of micrographia by recruiting additional brain networks. Levodopa improves consistent micrographia by restoring the function of the basal ganglia motor circuit, but does not improve progressive micrographia, probably because of failure to repair the disconnected networks. © The Author (2015). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  11. Creutzfeldt-Jakob disease. What is the role of magnetic resonance tomography?; Creutzfeldt-Jakob-Krankheit. Welche Rolle spielt die MR-Tomographie?

    Energy Technology Data Exchange (ETDEWEB)

    Kujat, C. [Inst. fuer Neuroradiologie der Univ. des Saarlandes, Homburg (Germany); Hagen, T. [Inst. fuer Neuroradiologie der Univ. des Saarlandes, Homburg (Germany); Feiden, W. [Abt. fuer Neuropathologie der Univ. des Saarlandes, Homburg (Germany)

    1995-11-01

    We report three patients with histologically confirmed CJD and confirm that MRI is a valuable tool for the diagnosis of this disease. (orig./MG) [Deutsch] Anhand der MRT-Ergebnisse von 3 Patienten mit histologisch gesicherter CJD und einer Literaturrecherche wird untersucht, ob die MRT einen Beitrag zur Diagnostik der CJD leisten kann. (orig./MG)

  12. Die funksie van die skeppingstradisie in die boek Jeremia

    African Journals Online (AJOL)

    gedeeites voor wat sterk ooreenkomste toon met die beskrywings van die skep pingsgebeure in die boek Jeremia. • Volgpns Von Rad (1957:144-146) het daar wel 'n groep bestaan wat belange ge- had liet by die oorlewering van die skeppingstradisies. Dit was waarskynlik die. Sadokitiese priesters wat om twee redes aan ...

  13. Die persoonlikheidsamestelling van die beskeie leerder in die ...

    African Journals Online (AJOL)

    Erna Kinsey

    Die goedaangepaste persoonlikheid vorm die basis van geestes- gesondheid en stel die mens in staat tot selfaktualisering. Selfaktua- lisering, wat volgens Maslow die hoogste vorm van menslike behoef- tes is, dui op die motivering van die mens om tot sy beste moontlike potensiaal te ontwikkel (Santrock, 2000:372; Smith, ...

  14. Die regsposisie van die gemolesteerde kind 1

    Directory of Open Access Journals (Sweden)

    P.J. Schabort

    1991-03-01

    Full Text Available Hoe reik die reg uit na die seksueel gemolesteerde kind? As na die reg in wye verband gekyk word, sou dit alie wetgewing en alle gemeneregsbeginsels en alle regsprosedures insluit waardeur die Staat poog om molestering te voorkom en die gemolesteerde kind in beskerming te neem. Dit le baie wyd en sou byvoorbeeld die maatreels insluit van die Kindenvet 33 van 1960; die Wet op Egskeiding 70 van 1979; die Wet op Kindersorg 74 van 1983; die Wet op die Status van Kinders 82 van 1987 en die Wet op Bemiddeling in Sekere Egskeidingsaangeleenthede 24 van 1987. Eersdaags sal dit moontlik ook ’n Manifes vir die Regte van Kinders insluit wat vermoedelik geskoei sal wees op die W O se Konvensie vir die Regte van die Kind (1989 w a arv an die RSA tan s nog nie ’n ondertekenaar is nie.

  15. Sputtered protective coatings for die casting dies

    Science.gov (United States)

    Mirtich, M. J.; Nieh, C.-Y.; Wallace, J. F.

    1981-01-01

    Three experimental research designs investigating candidate materials and processes involved in protective die surface coating procedures by sputter deposition, using ion beam technologies, are discussed. Various pre-test results show that none of the coatings remained completely intact for 15,000 test cycles. The longest lifetime was observed for coatings such as tungsten, platinum, and molybdenum which reduced thermal fatigue, but exhibited oxidation and suppressed crack initiation only as long as the coating did not fracture. Final test results confirmed earlier findings and coatings with Pt and W proved to be the candidate materials to be used on a die surface to increase die life. In the W-coated specimens, which remained intact on the surface after thermal fatigue testing, no oxidation was found under the coating, although a few cracks formed on the surface where the coating broke down. Further research is planned.

  16. Coeliac disease : investigation of the genetic factors underlying coeliac disease

    NARCIS (Netherlands)

    Belzen, M.J. (Martine Juliana) van

    2003-01-01

    Coeliac disease is a common food intolerance with a complex genetic aetiology. It is caused by ingestion of gluten peptides from wheat and related proteins from barley and rye in genetically susceptible individuals. The disease affects the small intestine and leads to abnormalities ranging from the

  17. Mitochondrial dysfunction underlying outer retinal diseases

    DEFF Research Database (Denmark)

    Lefevere, Evy; Toft-Kehler, Anne Katrine; Vohra, Rupali

    2017-01-01

    Dysfunction of photoreceptors, retinal pigment epithelium (RPE) or both contribute to the initiation and progression of several outer retinal disorders. Disrupted Müller glia function might additionally subsidize to these diseases. Mitochondrial malfunctioning is importantly associated with outer...... of mitochondrial dysfunction, indicating that mitochondria represent a weak link in the antioxidant defenses of outer retinal cells....

  18. Computed tomography in the diagnosis of inflammatory bowel disease - methodics of MSCT and clinical results; Die Computertomographie in der Diagnostik entzuendlicher Darmerkrankungen: Methodik der MSCT und klinische Ergebnisse

    Energy Technology Data Exchange (ETDEWEB)

    Bitterling, H.; Rock, C.; Reiser, M. [Institut fuer Klinische Radiologie, Klinikum der Universitaet Muenchen (Germany)

    2003-01-01

    This paper discusses the diagnostic yield of multislice computed tomography (MSCT) in inflammatory bowel disease. Contrast media are administered intraluminally (colon, small intestine) and intravenously (triple contrast CT).Filling of small bowel is achieved by means of jejunal tube (''Sellink CT'') or via the oral route. Pharmacological relaxation of the intestine decreases motion artifact. Intraluminal contrast media consist of either hyperdense, ''positive'' or hypodense, ''negative'' liquids. Thin-slice MSCT of the entire abdomen allows high-quality post processing (MPR, thin-slice MIP). Due to superior distension, Sellink CT improves estimation of stenosis or changes in thickness and contrast of bowel wall.Positive contrast is superior in the detection and preoperative localization of abscess, fistula or conglomerate tumour, because it accurately differentiates between intra- and extraluminal structures.However, negative contrast facilitates quantitative evaluation of bowel wall thickening or enhancement and demonstrates gastrointestinal bleeding. MSCT of the small intestine is superior to conventional enteroclysis, especially in the diagnosis of mesenterial or other extraintestinal disease. As a side effect, the colon is assessed in the same examination. Radiation dose is less in MSCT (7.8-13.3 mSv) than in conventional fluoroscopy (13.99{+-}7.57 mSv). MSCT can be performed as an alternative or adjunct to colonoscopy, if endoscopic access is restricted. It is already the imaging modality of choice in acute diverticulitis. (orig.) [German] Zielsetzung Die vorliegende Arbeit betrachtet die Aussagekraft der Mehrschichtspiral-CT (MSCT) fuer die Diagnostik entzuendlicher Darmerkrankungen.Methodik Die Kontrastierung erfolgt an Duenn- und Dickdarm kombiniert mit intravenoesem Kontrast (Tripel-Kontrast-CT). Die Duenndarmfuellung kann mittels Jejunalsonde (Sellink-CT) oder oral erfolgen, zusaetzlich erfolgt

  19. Die toksikologiese telefoniese konsultasies gerig aan die ...

    African Journals Online (AJOL)

    Die toksikologiese telefoniese konsultasies gerig aan die Departement Farmakologie van die Universiteit van die Vrystaat gedurende 1998/ The toxicology telephonic consultations directed to the department of pharmacology of the University of the Free State during 1998.

  20. Die moedertaal van Jesus*

    Directory of Open Access Journals (Sweden)

    S.J. du Plessis

    1963-03-01

    Full Text Available Anderhalf eeu lank het geleerdes aangeneem dat die enigste taal wat deur die bree volkslae in Palestina gepraat is in die tyd van Jesus, Aramees was. In 1817 het De Wette onder andere geskrywe: „Die benaming Hebreeus kom vir die eerste keer in die Apokriewe Boeke voor. Maar daar beteken dit die heersende volkstaal Aramees, wat teen daardie tyd (die tyd toe die Apokriewe ontstaan het reeds die plek van die ou Hebreeus ingeneem het”.

  1. Die redaksionele geskiedenis van die boek Hosea

    African Journals Online (AJOL)

    tuur kom rá' gewoonlik voor as antoniem van sdq. Op grond van die voorafgaande kan die hipotese gestel word dat die redaktor uit die wysheidskringe wat die profesieë van Hosea van 'n inleiding en slot voorsien het, dit nie as los aanhangsels gedoen het nie, maar dat dit bedoel was as integrale deel van die boek.

  2. DIE ONTSTAAN EN ONTWIKKELING VAN DIE VLOOT

    African Journals Online (AJOL)

    1 Feb 1980 ... ter See (See- ward Defence Force - SDF) as die eerste per- manente vlooteenheid in Suid-Afrika in te stel. Die SDF is op 15 Januarie. 1940 formeel gekonstitueer. Die lede van die SANS is outoma- ties daarna oorgeplaas, maar die RNVR (SA) het onafhanklik bly voortfunksioneer. Die SDF het aanvanklik.

  3. Evalueringskriteria en die interaksie tussen die leksikografieteorie ...

    African Journals Online (AJOL)

    user

    Opsomming: Die samestellers van die verskillende dele van die WAT kon steun op die insette van verskeie medewerkers, waarvan woordeboekresensente 'n belangrike groep is. Een van die algemene probleme met die evaluering van woordeboeke van allerlei soorte (sien Nielsen 2006,. 2009 en Swanepoel 2008, 2013 ...

  4. New measures to capture end of life concerns in Huntington disease: Meaning and Purpose and Concern with Death and Dying from HDQLIFE (a patient reported outcomes measurement system)

    Science.gov (United States)

    Carlozzi, N.E.; Downing, N.R.; McCormack, M.K.; Schilling, S.G.; Perlmutter, J.S.; Hahn, E. A.; Lai, J.-S.; Frank, S.; Quaid, K.A.; Paulsen, J. S.; Cella, D.; Goodnight, S.M.; Miner, J.A.; Nance, M.A.

    2016-01-01

    Purpose Huntington disease (HD) is an incurable terminal disease. Thus, end of life (EOL) concerns are common in these individuals. A quantitative measure of EOL concerns in HD would enable a better understanding of how these concerns impact health-related quality of life. Therefore, we developed new measures of EOL for use in HD. Methods An EOL item pool of 45 items was field tested in 507 individuals with prodromal or manifest HD. Exploratory and confirmatory factor analyses (EFA and CFA, respectively) were conducted to establish unidimensional item pools. Item response theory (IRT) and differential item functioning analyses were applied to the identified unidimensional item pools to select the final items. Results EFA and CFA supported two separate unidimensional sets of items: Concern with Death and Dying (16 items), and Meaning and Purpose (14 items). IRT and DIF supported the retention of 12 Concern with Death and Dying items and 4 Meaning and Purpose items. IRT data supported the development of both a computer adaptive test (CAT) and a 6-item, static short-form for Concern with Death and Dying. Conclusions The HDQLIFE Concern with Death and Dying CAT and corresponding 6-item short form, and the 4-item calibrated HDQLIFE Meaning and Purpose Scale demonstrate excellent psychometric properties. These new measures have the potential to provide clinically meaningful information about end of life preferences and concerns to clinicians and researchers working with individuals with HD. In addition, these measures may also be relevant and useful for other terminal conditions. PMID:27393121

  5. Epigenetic mechanisms underlying nervous system diseases.

    Science.gov (United States)

    Qureshi, Irfan A; Mehler, Mark F

    2018-01-01

    Epigenetic mechanisms act as control systems for modulating genomic structure and activity in response to evolving profiles of cell-extrinsic, cell-cell, and cell-intrinsic signals. These dynamic processes are responsible for mediating cell- and tissue-specific gene expression and function and gene-gene and gene-environmental interactions. The major epigenetic mechanisms include DNA methylation and hydroxymethylation; histone protein posttranslational modifications, nucleosome remodeling/repositioning, and higher-order chromatin reorganization; noncoding RNA regulation; and RNA editing. These mechanisms are intimately involved in executing fundamental genomic programs, including gene transcription, posttranscriptional RNA processing and transport, translation, X-chromosome inactivation, genomic imprinting, retrotransposon regulation, DNA replication, and DNA repair and the maintenance of genomic stability. For the nervous system, epigenetics offers a novel and robust framework for explaining how brain development and aging occur, neural cellular diversity is generated, synaptic and neural network connectivity and plasticity are mediated, and complex cognitive and behavioral phenotypes are inherited transgenerationally. Epigenetic factors and processes are, not surprisingly, implicated in nervous system disease pathophysiology through several emerging paradigms - mutations and genetic variation in genes encoding epigenetic factors; impairments in epigenetic factor expression, localization, and function; epigenetic mechanisms modulating disease-associated factors and pathways; and the presence of deregulated epigenetic profiles in central and peripheral tissues. Copyright © 2018 Elsevier B.V. All rights reserved.

  6. Hyperhemolysis Syndrome without Underlying Hematologic Disease

    Directory of Open Access Journals (Sweden)

    Lauren Anne Eberly

    2015-01-01

    Full Text Available Introduction. Hyperhemolysis is characterized by a life-threatening hemolytic transfusion reaction, with hemoglobin (Hb and hematocrit (Hct dropping markedly lower than before transfusion. This phenomenon, commonly described in sickle cell disease, is a rare occurrence in patients without hemoglobinopathies. Case Report. A 55-year-old male presented to the hospital after a motorcycle crash and received 10 units of cross-matched blood for active bleeding. The patient was blood group O, with a negative antibody screen. Ten days later, he represented complaining of dyspnea and was found to have a hematocrit of 12%. The direct antiglobulin test was positive for anti-immunoglobin G and complement. Indirect antiglobulin test was positive for anti-Jka alloantibodies. The presence of Jka antigen was revealed in one unit of previously transfused blood; patient’s RBCs were negative for the Jka antigen. Laboratory data demonstrated findings consistent with DHTR, as well as reticulopenia and elevated ferritin levels. He continued to show signs of active hemolysis, requiring a total of 4 subsequent units of pRBCs. Each transfusion precipitated a drop in Hb and Hct to levels lower than before transfusion; once transfusions were held, the patient slowly recovered. Discussion. Hyperhemolysis in the setting of a DHTR can occur in patients without hematologic disease.

  7. Streptococcus bovis bacteremia and underlying gastrointestinal disease.

    Science.gov (United States)

    Murray, H W; Roberts, R B

    1978-07-01

    Twenty-six adults with Streptococcus bovis endocarditis and ten with bacteremia alone were studied to determine possible portals of entry. Of 36 patients (17 with endocarditis, eight with bacteremia alone), 25 had gastrointestinal lesions or manipulation. In 22, the gastrointestinal tract appeared to be the source of S bovis bacteremia. Four patients had either carcinoma of the colon (two) or potentially malignant villous adenomas (two) when first seen because of S bovis bacteremia. None of these, nor two other patients with benign colonic polyps, had bowel-related symptoms or signs prior to admission. Since S bovis is a normal intestinal tract inhabitant, bacteremia may frequently be associated with bowel lesions. Streptococcus bovis bacteremia may provide an early clue to the presence of serious and clinically unexpected gastrointestinal disease. Gastrointestinal tract evaluation should be part of S bovis bacteremia patient management, with or without endocarditis.

  8. . , , die Boesmans

    African Journals Online (AJOL)

    "made captive in early boyhood, with other children of a Bushman. Kraal, in one of the frequent incursions or commandos" (Pereira &. Chapman, 1989:157). Dit eindig met Pangóla wat sterf in 'n soortgelyke ongelyke geveg tussen berede boere en omsingelde Boesmans - gewere teen pyl-en-boë: "I die in arms against the ...

  9. Die woord vra kontak

    African Journals Online (AJOL)

    dit belangrik dat die redaksionele stelsel en die taalkundige gegewens wat in woordeboeke gehanteer word, in pas moet wees met die heersende gedag- terigtings in die taalkunde. Dit kan die maklikste bewerkstelling word indien die oop gesprek tussen die leksikograaf en die taalkundige voortdurend gesti- muleer word.

  10. [Extramammary Paget's disease of the scrotum with underlying sweat gland adenocarcinoma: a report of six cases with literature review].

    Science.gov (United States)

    Tu, Hua; Han, Hui; Zhou, Fang-Jian; Li, Yong-Hong; Qin, Zi-Ke; Liu, Zhuo-Wei

    2009-08-01

    Extramammary Paget's disease (EMPD) of the scrotum with sweat gland adenocarcinoma is a rare malignant tumor. This study was to summarize the clinicopathologic characteristics of scrotum Paget's disease with underlying sweat gland adenocarcinoma, and analyze the treatment outcome. Clinical data of six scrotum Paget's disease patients with sweat gland adenocarcinoma, treated in Sun Yat-sen University Cancer Center from 1964 to 2004, were analyzed with literature review. The typical manifestation of scrotum Paget's disease with sweat gland adenocarcinoma was eczematoid-like skin changes. All patients underwent primary lesion resection plus uni-inguinal lymphadenectomy, one patient underwent rectus abdominis pedicle flap transplantation. Three patients died of tumor at 15, 26, 38 months after operation, respectively. Other three patients were followed up for 48, 50, 55 months, respectively, and were alive without tumor. The primary lesion resection plus uni-inguinal lymphadenectomy is the major treatment for scrotum Paget's disease with underlying sweat gland adenocarcinoma.

  11. Disease course and management strategy of pouch neoplasia in patients with underlying inflammatory bowel diseases.

    Science.gov (United States)

    Wu, Xian-Rui; Remzi, Feza H; Liu, Xiu-Li; Lian, Lei; Stocchi, Luca; Ashburn, Jean; Shen, Bo

    2014-11-01

    To evaluate the disease course and management strategy for pouch neoplasia. Patients undergoing ileal pouch surgery for underlying ulcerative colitis who developed low-grade dysplasia (LGD), high-grade dysplasia, or adenocarcinoma in the pouch were identified. All eligible 44 patients were evaluated. Of the 22 patients with initial diagnosis of pouch LGD, 6 (27.3%) had persistence or progression after a median follow-up of 9.5 (4.1-17.6) years. Family history of colorectal cancer was shown to be a risk factor associated with persistence or progression of LGD (P = 0.03). Of the 12 patients with pouch high-grade dysplasia, 5 (41.7%) had a history of (n = 2, 16.7%) or synchronous (n = 4, 33.3%) pouch LGD. Pouch high-grade dysplasia either persisted or progressed in 3 patients (25.0%) after the initial management, during a median time interval of 5.4 (2.2-9.2) years. Of the 14 patients with pouch adenocarcinoma, 12 (85.7%) had a history of (n = 2, 14.3%) or synchronous dysplasia (n = 12, 85.7%). After a median follow-up of 2.1 (0.6-5.2) years, 6 patients with pouch cancer (42.9%) died. Comparison of patients with a final diagnosis of pouch adenocarcinoma (14, 32.6%), and those with dysplasia (29, 67.4%) showed that patients with adenocarcinoma were older (P = 0.04) and had a longer duration from IBD diagnosis or pouch construction to the detection of pouch neoplasia (P = 0.007 and P = 0.0013). The risk for progression of pouch dysplasia can be stratified. The presence of family history of colorectal cancer seemed to increase the risk for persistence or progression for patients with pouch LGD. The prognosis for pouch adenocarcinoma was poor.

  12. Die doop in die Gereformeerde Kerkorde

    Directory of Open Access Journals (Sweden)

    C. J. Smit

    1989-05-01

    Full Text Available Dit is veelseggend dat die klassiek geworde Gereformeerde Doopformulier aan ’n kerkorde ontleen is. Hierdie kerkorde is die van die Palts wat in opdrag van die keurvors Frederik die Vrome opgestel en in 1563 ingevoer is.

  13. DIE ONTWIKKELING VAN DIE VROU AS SOLDAAT

    African Journals Online (AJOL)

    Foto: 'Women in Battle' deur John. Laffin. Die Enge/se vrou was spoedig reeds by die verdediging van haar land betrokke. So vroeg as. 1761 het die Jaarlikse Register aangetoon dat. Engelse vroue wat hulle mans op die slagveld gevolg het deur 'n uniform aan te trek, uitgevind is.5. Die. Amerikaanse. Vryheidsoorlog.

  14. Die universiteit en die goeie lewensorde

    African Journals Online (AJOL)

    op Hippocrates, Galenus en Avicenna, lettere op Aristoteles, en ná die. Reformasie sou Luther, Melanchton en Calvyn vir Petrus Lombardus aan dié universiteite vervang wat vir die Reformasie gekies het, maar sou die ander fakulteite in hoofsaak onaangeraak bly. Die universiteit het sy tradisie binne die voile stroom van ...

  15. Does a carpal tunnel syndrome predict an underlying disease?

    NARCIS (Netherlands)

    M.C. de Rijk (Maarten); F.H. Vermeij (Frederique); M. Suntjens (Maartje); P.A. van Doorn (Pieter)

    2007-01-01

    textabstractCarpal tunnel syndrome (CTS) may be the presenting symptom of an underlying disease such as diabetes mellitus, hypothyroidism or connective tissue disease (CTD). It was investigated whether additional blood tests (glucose level, thyroid-stimulating hormone level and erythrocyte

  16. Die ouderling en die regeervergaderings in die Nederduitsch ...

    African Journals Online (AJOL)

    Nederduitsch Hervormde Kerk van Afrika 1%1. Notule van die Algemene Kerk- vergadering 1961. Argief van die Nerderduitsch Hervormde Kerk, Pretoria. — 1979. Notule van die Algemene Kerkvergadering 1979. Argief van die Neder duitsch Hervormde Kerk, Pretoria. — 1989a. Kerkwet en Bepalings. Pretoria: Gutenberg.

  17. Die hervertolking van die paradigma in verband met die ...

    African Journals Online (AJOL)

    sal hom ook nie aan die dink sit nie. Om een van sy woorde te gebruik, ek het dit. 'gepleeg' omdat hy my geleer en aan die dink gesit het. KoUcgUlismc. 2. INLEIDING. In sy lofwaardige poging om die negentiende-eeuse Hervormde Kerk van Nederland te reformeer, het Abraham Kuyper die dwaling van hierdie kerk onder ...

  18. Die hervertolking van die paradigma in verband met die ...

    African Journals Online (AJOL)

    Die hervertolking van die paradigma in verband met die Kollegialisme om die. Afrikaanse kerke kerkregtelik te verstaan. E Brown. Universiteit van Stellenbosch. Abstract. Reinterpreting the paradigm concerning 'Kollegialisme' in order to understand the Afrikaans churches accoring to church law. The Afrikaans term ...

  19. Die belangrikste kenmerk van die diereproduksie- bedrywe oor die ...

    African Journals Online (AJOL)

    digdhede teen 1980 uit 'n kudde van 30 rnilj.skape ge- produseer moet word. Tweedens sal die faktore bespreek word wat betrokke is by die winsgewendheid van inten- siewe afronding van vroeggespeende lammers in voerkrale. Dit word algemeen aanvaar dat die bevolking van die Republiek van Suid-Mrika teen 1980 ...

  20. Die kerkregtelike posisie van die ouderling en diaken in die ...

    African Journals Online (AJOL)

    ... drie dekades die Kerkreg gevestig as 'n selfstandige vak in die teologiese curriculum, maar ook 'n baie groot rol gespeel daarin dat die beginsels van die kerk like reg beter begryp word. Naas sy wetenskaplike bydrae word met eweveel genoegdoening gedink aan sy bcsondere persoonlikheid, sy werkvermoe, sy humor-.

  1. Die museum se rol in die aankweek van 'n omgewingsbewustheid ...

    African Journals Online (AJOL)

    Die museum se rol in die aankweek van 'n omgewingsbewustheid. Martie van der Merwe. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · Creative Commons License This work is licensed under a Creative Commons Attribution 3.0 ...

  2. Price abuse monitoring under paragraph 29 of the Law Against Restraints on Competition; Die Preismissbrauchskontrolle nach paragraph 29 GWB

    Energy Technology Data Exchange (ETDEWEB)

    Koleva, Raliza

    2013-08-01

    Written against the backdrop of criticism levelled at paragraph 29 of the Law Against Restraints on Competition (GWB) the present study undertakes a critical discussion of this legal norm along with questions and points of criticism that have been raised in its context in the literature and case law. It first addresses the central question as to whether paragraph 29 GWB conforms to the stipulations of European law and the German constitution. It then expounds the system behind paragraph 29 GWB, making a detailed examination of the individual elements of the offences covered by the regulation while giving thorough consideration to existing case law on instruments of price abuse monitoring that have been used to date under cartel law. A further focus of the present study is on the question as to what circumstances a supply company under suspicion of price abuse may claim in attempting to justify significant differences that have been found to exist between its own prices and those of a comparable company. This aspect is of great practical relevance in lawsuits concerning price abuse under cartel law, since the option of demonstrating justification is the most important line of approach for supply companies under suspicion of price abuse in attempting to fend off such allegations. Based on an analysis of past practice of the German Federal Cartel Office and the antitrust courts the author undertakes to determine a scale for assessing the costs which the responding supply company can claim in its defence. Finally she endeavours to methodologically capture the price limit concept, making proposals for its practical application with due consideration to the findings that have transpired from the study.

  3. Die kritiese taak van die literator

    Directory of Open Access Journals (Sweden)

    A. L. Combrink

    1981-05-01

    Full Text Available Die beoefening van die literêre kritiek was aanvanklik slegs ’n deeltydse aktiwiteit. Die vroegste literêre kritici was nie as sodanig kritici nie maar het as deel van hulle totale intellektuele aktiwiteit hulle ook uitgelaat oor die letterkunde. Die motivering wat hulle hiertoe gehad het sou in ons dag heeltemal verdag voorkom: ’n uitgesproke didaktiese of moraliserende houding was die reel.

  4. Die gesigte van die neo-marxisme

    Directory of Open Access Journals (Sweden)

    M. C. Boshoff

    1979-05-01

    Full Text Available Ons weet nie sondermeer wat die voorsetsel ‘NEO’ beteken nie. Het Marx in ons tyd herleef of ’n ombuiging, hersiening, aanvulling of selfs ’n korrektief op die oorspronklike visie van Marx gekom? Wat hou die naam, doelstellings en gees van Karl Marx lewendig en dreig om die Westerse lewenswyse en die Christelike godsdiens te vernietig met ’n leefwyse wat die Christelike geloof op sy kardinale punte aanval?

  5. The impact of the document international work group in death, dying and bereavement: assumptions and principles underlying standards for terminal care.

    Science.gov (United States)

    Vachon, Mary L S

    This article reflects on the development and impact of the International Workgroup on Death, Dying and Bereavement's (IWG) pivotal document on The Assumptions and Principles Underlying Standards for Terminal Care. It was at the Ars Moriendi meetings in Columbia, Maryland that the author first met Bob and Bunny Kastenbaum. The meeting led to the development of IWG and the first task of this group was the development of the "Standards" document. The initial document reflected the pioneering work already being done by Kastenbaum and others on the committee and then was formative in the development of other documents such as the National Hospice Association Standards. Participants in the original workgroup were asked for their reflections on the significance of the document and the literature was surveyed to assess the impact of the "Standards" document on the field.

  6. Die Kernmethode Wertstromdesign

    OpenAIRE

    Schöllhammer, Oliver

    2014-01-01

    Anhand eines Fallbeispiels wird die Methode des Administrativen Wertstromdesigns vorgestellt. Kern Themen sind die Vorbereitung, die Ist-Analyse und die Definition eines Soll-Zustandes. Diese werden Schritt für Schritt detailliert beschrieben.

  7. Maintaining Low Voiding Solder Die Attach for Power Die While Minimizing Die Tilt

    Energy Technology Data Exchange (ETDEWEB)

    Hamm, Randy; Peterson, Kenneth A.

    2015-10-01

    This paper addresses work to minimize voiding and die tilt in solder attachment of a large power die, measuring 9.0 mm X 6.5 mm X 0.1 mm (0.354” x 0.256” x 0.004”), to a heat spreader. As demands for larger high power die continue, minimizing voiding and die tilt is of interest for improved die functionality, yield, manufacturability, and reliability. High-power die generate considerable heat, which is important to dissipate effectively through control of voiding under high thermal load areas of the die while maintaining a consistent bondline (minimizing die tilt). Voiding was measured using acoustic imaging and die tilt was measured using two different optical measurement systems. 80Au-20Sn solder reflow was achieved using a batch vacuum solder system with optimized fixturing. Minimizing die tilt proved to be the more difficult of the two product requirements to meet. Process development variables included tooling, weight and solder preform thickness.

  8. Intensive care at the end of life in patients dying due to non-cancer chronic diseases versus cancer: a nationwide study in Denmark.

    Science.gov (United States)

    Lyngaa, Thomas; Christiansen, Christian Fynbo; Nielsen, Henrik; Neergaard, Mette Asbjørn; Jensen, Anders Bonde; Laut, Kristina Grønborg; Johnsen, Søren Paaske

    2015-11-24

    It is unknown to what extent use of palliative care and focus on proactive planning of end-of-life (EOL) care among cancer patients is also reflected by less use of intensive care. We aimed to examine the use of intensive care in the EOL in patients dying as a result of non-cancer diseases compared with patients dying due to cancer. We conducted a nationwide follow-up study among 240,757 adults dying as a result of either non-cancer chronic disease or cancer in Denmark between 2005 and 2011. Using the Danish Intensive Care Database, we identified all admissions and treatments in intensive care units (ICU) during the patients' last 6 months before death. We used prevalence ratios (aPRs) adjusted for age, sex, comorbidity, marital status and residential region to compare the 6-month prevalence of ICU admissions as well as treatment with invasive mechanical ventilation (MV), non-invasive ventilation (NIV), renal replacement therapy (RRT) and inotropes and/or vasopressors. In addition, length of ICU stay and death during ICU admission were compared among non-cancer and cancer patients dying between 2009 and 2011. Overall 12.3 % of non-cancer patients were admitted to an ICU within their last 6 months of life, compared with 8.7 % of cancer patients. The overall aPR for ICU admission was 2.11 [95 % confidence interval (CI) 1.98-2.24] for non-cancer patients compared with cancer patients and varied widely within the non-cancer patients (patients with dementia, aPR 0.19, 95 % CI 0.17-0.21; patients with chronic obstructive lung disease, aPR 3.19, 95 % CI 2.97-3.41). The overall aPRs for treatment among non-cancer patients compared with cancer patients were 1.40 (95 % CI 1.35-1.46) for MV, 1.62 (95 % CI 1.50-1.76) for NIV, 1.19 (95 % CI 1.07-1.31) for RRT and 1.05 (95 % CI 0.87-1.28) for inotropes and/or vasopressors. No difference in admission length was observed. Non-cancer patients had an increased risk of dying in an ICU (aPR 1.23, 95 % CI 0.99-1.54) compared with

  9. Ebola Virus Disease Candidate Vaccines Under Evaluation in Clinical Trials

    Science.gov (United States)

    Martins, Karen A.; Jahrling, Peter B.; Bavari, Sina; Kuhn, Jens H.

    2016-01-01

    Summary Filoviruses are the etiological agents of two human illnesses: Ebola virus disease and Marburg virus disease. Until 2013, medical countermeasure development against these afflictions was limited to only a few research institutes worldwide as both infections were considered exotic due to very low case numbers. Together with the high case-fatality rate of both diseases, evaluation of any candidate countermeasure in properly controlled clinical trials seemed impossible. However, in 2013, Ebola virus was identified as the etiological agent of a large disease outbreak in Western Africa including almost 30,000 infections and more than 11,000 deaths, including case exportations to Europe and North America. These large case numbers resulted in medical countermeasure development against Ebola virus disease becoming a global public-health priority. This review summarizes the status quo of candidate vaccines against Ebola virus disease, with a focus on those that are currently under evaluation in clinical trials. PMID:27160784

  10. DIE SLAG VAN BLOEDRIVIER~

    African Journals Online (AJOL)

    cast iron blown over with bronze stands today. ... deur 'n moerasagtige pan effens noord van die noordel ike drif. Ook hierdeur is die laer in 'n mate gedek. Meer na die suidweste het die bree. Gelato-kop, na die Slag 'Vechtkop' genoem, oor die laer getroon. HOGOsptl'nr. 'i'OSRASACT IGE: PAN. BLOEDRIVI3R. S'S.

  11. Die agogiese moment in die pastoraat

    Directory of Open Access Journals (Sweden)

    A. P. C. Duvenage

    1972-06-01

    Full Text Available Die verwarring wat daar vandag in die diakonologiese groep vakke heers, word ten dele weerspieël in die verskeie uitdrukkings en woorde wat gebruik word. By verskillende mense het dit heeltemal verskillende inhoude. Daarom dink ek is dit nodig om te begin met ’n begripsbepaling, om dan later oor die saak te praat.

  12. Declining Prevalence of Disease Vectors Under Climate Change

    Science.gov (United States)

    Escobar, Luis E.; Romero-Alvarez, Daniel; Leon, Renato; Lepe-Lopez, Manuel A.; Craft, Meggan E.; Borbor-Cordova, Mercy J.; Svenning, Jens-Christian

    2016-12-01

    More than half of the world population is at risk of vector-borne diseases including dengue fever, chikungunya, zika, yellow fever, leishmaniasis, chagas disease, and malaria, with highest incidences in tropical regions. In Ecuador, vector-borne diseases are present from coastal and Amazonian regions to the Andes Mountains; however, a detailed characterization of the distribution of their vectors has never been carried out. We estimate the distribution of 14 vectors of the above vector-borne diseases under present-day and future climates. Our results consistently suggest that climate warming is likely threatening some vector species with extinction, locally or completely. These results suggest that climate change could reduce the burden of specific vector species. Other vector species are likely to shift and constrain their geographic range to the highlands in Ecuador potentially affecting novel areas and populations. These forecasts show the need for development of early prevention strategies for vector species currently absent in areas projected as suitable under future climate conditions. Informed interventions could reduce the risk of human exposure to vector species with distributional shifts, in response to current and future climate changes. Based on the mixed effects of future climate on human exposure to disease vectors, we argue that research on vector-borne diseases should be cross-scale and include climatic, demographic, and landscape factors, as well as forces facilitating disease transmission at fine scales.

  13. Years of life lived with disease and years of potential life lost in children who die of cancer in the United States, 2009

    International Nuclear Information System (INIS)

    Blank, Peter M de; Ostrom, Quinn T; Rouse, Chaturia; Wolinsky, Yingli; Kruchko, Carol; Salcido, Joanne; Barnholtz-Sloan, Jill S

    2015-01-01

    Incidence and survival rates are commonly reported statistics, but these may fail to capture the full impact of childhood cancers. We describe the years of potential life lost (YPLL) and years of life lived with disease (YLLD) in children and adolescents who died of cancer in the United States to estimate the impact of childhood cancer in the United States in 2009. We examined mortality data in 2009 among children and adolescents <20 years old in both the National Vital Statistics System (NVSS) and the Surveillance, Epidemiology, and End Results (SEER) datasets. YPLL and YLLD were calculated for all deaths due to cancer. Histology-specific YPLL and YLLD of central nervous system (CNS) tumors, leukemia, and lymphoma were estimated using SEER. There were 2233 deaths and 153,390.4 YPLL due to neoplasm in 2009. CNS tumors were the largest cause of YPLL (31%) among deaths due to cancer and were the cause of 1.4% of YPLL due to all causes. For specific histologies, the greatest mean YPLL per death was due to atypical teratoid/rhabdoid tumor (78.0 years lost). The histology with the highest mean YLLD per death in children and adolescents who died of cancer was primitive neuroectodermal tumor (4.6 years lived). CNS tumors are the most common solid malignancy in individuals <20 years old and have the highest YPLL cost of all cancers. This offers the first histology-specific description of YPLL in children and adolescents and proposes a new measure of cancer impact, YLLD, in individuals who die of their disease. YPLL and YLLD complement traditional indicators of mortality and help place CNS tumors in the context of other childhood malignancies

  14. die sinodale verband van die nederduitse gereformeerde kerk in die

    African Journals Online (AJOL)

    Liezel

    daartoe gelei dat daar na dié hofsaak verskillende sinodale verbande in ver- skillende state of kolonies in ... Grootrivier gebring moet word, aldus Van de Wall, maar die kerk kon nie deur staatsgrense beperk word nie. .... Op die punt van lidmaatskap wou die Sinode, trou aan sy gereformeerde gesindheid, nie sondermeer ...

  15. DIE ROL VAN DIE TAALWETENSKAP IN DIE ONTWIKKELING VAN ...

    African Journals Online (AJOL)

    aanslag op die sogenaamde "Intentional Fallacy", heelwat verder. n. Mens sou hier eintlik ook op die invloed van Lacan se toepassing van. De Sacs sure op Freud moet wys, en op Macherey se Theory of Literary. Production. Barthes is naamlik besig om repressie teen te werk, en die teks as produksieproses in stede van ...

  16. Wat is die reg en die vryheid van die eksegeet?

    African Journals Online (AJOL)

    voorgestaan terwyl die Antiocheense skool (Joh Chrysostemos en. Theodorus van Mopsuesta) weer as eksegese gesien het 'n meer letterlike verklaring van die Bybel. Augustinus en Hieronimus het probeer om die twee metodes te kombineer, terwyl Petrus. Lombardus, Alexander van Hailes en Thomas Aquinas 'n vier-.

  17. Veno-occlusive liver disease after infradiaphragmatic total lymphoid irradiation. A rare complication; Die Venenverschlusskrankheit der Leber nach infradiaphragmaler total lymphatischer Bestrahlung. Eine seltene Nebenwirkung

    Energy Technology Data Exchange (ETDEWEB)

    Bischof, M.; Zierhut, D.; Gutwein, S.; Wannenmacher, M. [Heidelberg Univ. (DE.) Abt. fuer Klinische Radiologie - Schwerpunkt Strahlentherapie; Hansmann, J. [Heidelberg Univ. (DE.) Abt. fuer Radiologische Diagnostik; Stremmel, W.; Mueller, M. [Heidelberg Univ. (DE). Abt. Innere Medizin 4 (Schwerpunkt Gastroenterologie)

    2001-06-01

    Background: Radiotherapy is potentially curative in early stages of follicle center lymphoma. Frequent side effects are pancytopenia, nausea and abdominal discomfort. A radiation-induced liver injury with serious clinical symptoms and changes in liver function is a rare complication. Case report: Whole abdomen was irradiated in a 49-year-old-patient with a centrocytic-centroblastic lymphoma, stage IA (localization: Left inguinal region). A total dose of 30 Gy was delivered in a weekly fractionation of five times 1.5 Gy. Kidneys were protected by shielding after a dose of 13.5 Gy, liver blocks were positioned after 25 Gy. During the last 2 days of therapy the patient presented with weight gain, ascites, dyspnoea and elevated liver enzymes. Diagnostics revealed hepatosphlenomegaly, ascites and an increased portosystemic pressure gradient. Liver biopsy specimen showed a veno-occlusive disease. Complete relief of symptomatology was achieved within 7 days following placement of a transjugular intrahepatic portosystemic stent-shunt (TIPSS), heparinization and diuretics. Liver enzymes are in the normal range. Conclusion: Veno-occlusive disease of the liver (VOD) is a very rare side effect of primary abdominal irradiation of follicle center lymphoma. This complication should be taken into consideration if a patient presents with upper right quadrant pain, ascites and elevation of liver enzymes especially within 4 months following radiotherapy. Genesis of veno-occlusive disease, diagnostics, therapy and a review of the literature are presented. (orig.) [German] Hintergrund: Die Strahlentherapie spielt bei der kurativen Behandlung der Fruehstadien follikulaerer Keimzentrumslymphome die entscheidende Rolle. Therapiebegleitende Nebenwirkungen sind haeufig Panzytopenie, Nausea und abdominelle Beschwerden. Eine radiogen induzierte Leberschaedigung mit klinisch manifester Symptomatik und schwerer Leberfunktionsstoerung ist dagegen aeusserst selten. Fallbeschreibung: Bei einem 49

  18. A comparative analysis of polybrominated diphenyl ethers and polychlorinated biphenyls in southern sea otters that died of infectious diseases and noninfectious causes

    Science.gov (United States)

    Kannan, K.; Perrota, E.; Thomas, N.J.; Aldous, D.M.

    2007-01-01

    Southern sea otters (Enhydra lutris nereis) from the California coast continue to exhibit a slower population regrowth rate than the population in Alaska. Infectious diseases have been identified as a frequent cause of death. Infectious diseases caused by varied pathogens including bacteria, fungi, and parasites were suggestive of compromised immunological health of mature animals in this population. To test the hypothesis that elevated exposure to immunotoxic contaminants such as polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) contribute to disease susceptibility via immunosuppression, we determined concentrations of PBDEs and PCBs in livers of 80 adult female sea otters that died of infectious diseases, noninfectious causes, or emaciation. Concentrations of PBDEs and PCBs in sea otter livers varied widely (10a??26,800 ng/g and 81a??210,000 ng/g, lipid weight, respectively). Concentrations of PBDEs in sea otters were some of the highest values reported for marine mammals so far. Although PCB concentrations in sea otters have declined during 1992a??2002, the mean concentration was at the threshold at which adverse health effects are elicited. Concentrations of PBDEs and PCBs were significantly correlated, suggesting co-exposure of these contaminants in sea otters. No significant association was found between the concentrations of PBDEs and the health status of sea otters. Concentrations of PCBs were significantly higher in otters in the infectious disease category than in the noninfectious category, suggesting an association between elevated PCB concentrations and infectious diseases in Southern sea otters.

  19. Glomerular diseases and cancer: evaluation of underlying malignancy.

    Science.gov (United States)

    Pani, Antonello; Porta, Camillo; Cosmai, Laura; Melis, Patrizia; Floris, Matteo; Piras, Doloretta; Gallieni, Maurizio; Rosner, Mitchell; Ponticelli, Claudio

    2016-04-01

    Onconephrology is an emerging medical subspecialty focused on the numerous interconnections between cancer and kidney diseases. Patient with malignancies commonly experience kidney problems including acute kidney injury, tumor lysis syndrome, fluid and electrolyte disorders and chronic kidney disease, often as a consequence of the anti-cancer treatment. Conversely, a number of glomerulopathies, tubulopathies and vascular renal diseases can early signal the presence of an underlying cancer. Furthermore, the administration of immunosuppressive drugs, especially cytotoxic drugs and calcineurin inhibitors, may strongly impair the immune response increasing the risk of cancer. The objective of this review article is to: (i) discuss paraneoplastic glomerular disease, (ii) review cancer as an adverse effect of immunosuppressive agents used to treat glomerulopathies, and (iii) in the absence of international approved guidelines, propose a screening program based on expert opinion aimed at guiding nephrologists to early detect malignancies during their clinical practice.

  20. "For Their Own Good": A Response to Popular Arguments Against Permitting Medical Assistance in Dying (MAID) where Mental Illness Is the Sole Underlying Condition.

    Science.gov (United States)

    Dembo, Justine; Schuklenk, Udo; Reggler, Jonathan

    2018-01-01

    Canada is approaching its federal government's review of whether patients should be eligible for medical assistance in dying (MAID) where mental illness is the sole underlying medical condition, and when "natural death" is not "reasonably foreseeable". For those opposed, arguments involve the following themes: capacity, value of life, vulnerability, stigma, irremediability, and the role of physicians. It has also been suggested that those who are able-bodied should have to kill themselves, even though suicide may be painful, lonely, and violent. Opponents of MAID for severe, refractory suffering due to mental illness imply that it is acceptable to remove agency from such patients on paternalistic grounds. After years of efforts to destigmatise mental illness, these kinds of arguments effectively declare all patients with mental illness, regardless of capacity, unable to make considered choices for themselves. The current paper argues that decisions about capacity must be made on an individual-patient basis. Given the rightful importance granted to respect for patient autonomy in liberal democracies, the wholesale removal of agency advocated by opponents of a permissive MAID regime is difficult to reconcile with Canadian constitutional values.

  1. Halfkrone vir die Nagmaal

    African Journals Online (AJOL)

    Owner

    die omgewing van Velddrif en Laaiplek, ook noordwaarts verby Lambertsbaai tot by. Doringbaai en Strandfontein. “Haar seeverhale is Sussie (Kotze) se belangrikste bydrae tot die Afrikaanse letterkunde”, sê Kotzé-Myburgh in die voorwoord van die versamelbundel. Die leser word herinner aan Kotze se debuutroman, ...

  2. die ontstaan en die ontwikkeling van die skoolkadette-stelsel in die rsa

    African Journals Online (AJOL)

    higiene ook verpligtend was. 42. In die Goewerment Gazette van 4 Mei 1934 word die verantwoordelikheid vir die opstel van leerplanne vir kadette asook vir die inhou van kursusse aan die Direkteur van Militere Opera- sies en Opleiding opgedra. Volgens hierdie Ga- zette was elke seun verplig om 30 uur per jaar opleiding ...

  3. Development and application of inverse heat transfer model between liquid metal and shot sleeve in high pressure die casting process under non-shooting condition

    Directory of Open Access Journals (Sweden)

    Wen-bo Yu

    2016-07-01

    Full Text Available To predict the heat transfer behavior of A380 alloy in a shot sleeve, a numerical approach (inverse method is used and validated by high pressure die casting (HPDC experiment under non-shooting condition. The maximum difference between the measured and calculated temperature profiles is smaller than 3 ℃, which suggests that the inverse method can be used to predict the heat transfer behavior of alloys in a shot sleeve. Furthermore, the results indicate an increase in maximum interfacial heat flux density (qmax and heat transfer coefficient (hmax with an increase in sleeve filling ratio, especially at the pouring zone (S2 zone. In addition, the values of initial temperature (TIDS and maximum shot sleeve surface temperature (Tsimax at the two end zones (S2 and S10 are higher than those at the middle zone (S5. Moreover, in comparison with fluctuations in heat transfer coefficient (h with time at the two end zones (S2 and S10, 2.4-6.5 kW·m-2·K-1, 3.5-12.5 kW·m-2·K-1, respectively, more fluctuations are found at S5 zone, 2.1-14.7 kW·m-2·K-1. These differences could theoretically explain the formation of the three zones: smooth pouring zone, un-smooth middle zone and smooth zone, with different morphologies in the metal log under the non-shot casting condition. Finally, our calculations also reveal that the values of qmax and hmax cast at 680 ℃ are smaller than those cast at 660 ℃ and at 700 ℃.

  4. ,,Die kleur-krisis en die Weste"

    Directory of Open Access Journals (Sweden)

    J. H. Coetzee

    1953-03-01

    Full Text Available Wie vandag onbevange en met ’n opregte begeerte na die volle waarheid oor die sogenaamde „kleurvraagstuk” in Suid-Afrika wil skryf, moet voorwaard bid dat hom die deel van Esegiël te beurt mag val: „Jou voorhoof maak ek hard soos ’n diamant, harder as ’n rots . . . ."

  5. Die funksie van ruimte in die narratologie

    African Journals Online (AJOL)

    Venter (1985: 20 vv) is van mening dat hierdie negatiewe beoorde- ling van ruimte as blote 'vulling' (Venter 1985: 20) die beginsel was waarvolgens Plato in die ouer literêre paradigma byvoorbeeld die Ilias van Homerus so beskryf het dat alle ruimtelike gegewens sover moont- lik weggelaat is. Hiervolgens kon ruimte te ...

  6. KERKWEES IN DIE

    African Journals Online (AJOL)

    KERKWEES IN DIE BRANDING: DIE NEDERDUITSE GEREFORMEERDE. KERK IN ALGEMENE SINODALE VERBAND. 1994-2011. ACTA THEOLOGICA. Supplementum 18. 2013. INHOUD. HOOFSTUK 1 Verantwoording. 1. HOOFSTUK 2 Die Sinode van versoening? 4. HOOFSTUK 3 Bestendiging in 'n nuwe bedeling.

  7. Die skepping as gelykenis: 'n Beoordeling van die skeppingsleer ...

    African Journals Online (AJOL)

    en nie met 'n ontologie te doen nie. Die analogia relationis dra, in teenstelling met die vorige, nie die werklikheid oor nie, maar die moontlikheid. Barth vergelyk die teen stelling werklikheid-moontlikheid met die twee bome van die tuin; die van werklikheid (lewe) en die van moontlikheid (kennis) (KD III/l,. 291-295). Hierdie is ...

  8. Die betroubaarheid van die Nuwe Testament vanuit 'n tekskritiese ...

    African Journals Online (AJOL)

    die oud-Latynse manuskripte was een van die redes waarom die. Vulgaat, 'n standaarduitgawe van die Latynse teks, sy beslag gekry het. (vgl Metzger 1968a: 76). Hoewel die betroubaarheid van die teks van die Nuwe Testament dus lank voor die uitvinding van die boekdrukkuns 'n erkende pro bleem was, was dit egter ...

  9. Die funksie van die ^danksegging(s)' in 1 Tessalonisense

    African Journals Online (AJOL)

    53 Die ooiredingsmiddele gebruik ter ondersteuning van die argument. Die verskillende oorredingsmiddele wat in die antieice retorieic aangewend is (kyk. Aristoteles, Ars Rhetorica 1.1), sluit onder meer die volgende in: ethos, pathos en logos. Die oortuigingsmiddel pathos dien die doel om die karakter van die impiisiete.

  10. Underlying diseases in syncope of children in China

    Science.gov (United States)

    Li, Chen; Cheng, Wang; Hongwei, Wang; Hong, Tian; Chaoshu, Tang; Hongfang, Jin; Junbao, Du

    2011-01-01

    Summary Background Syncope accounts for about 1–2% of emergency department visits, but the etiology in many patients with syncope is unclear. Recently, with the use of the head-up tilt test (HUT), the number of patients with unexplained syncope (UPS) has been decreasing; however, the spectrum of underlying diseases of syncope in children is unclear. This retrospective study aimed to analyze the spectrum of underlying diseases in children with syncope. Material/Methods This multi-center clinical study consisted of 888 children (417 males, 471 females, aged 5–18 yrs, median age 12.0±3.0 yrs) with syncope who came from Beijing city, Hunan province, Hubei province and Shanghai from August 1999 to March 2009. The clinical and laboratory data of children were studied and the spectrum of underlying diseases in children with syncope was analyzed. Results In 888 children with syncope, 175 (19.7%) had vasovagal syncope (VVS) with vasoinhibitory response, 35 (3.9%) had VVS with cardioinhibitory response, 73 (8.2%) had VVS with mixed response, 286 (32.2%) had postural orthostatic tachycardia syndrome (POTS), 19 (2.1%) had orthostatic hypotension, 7 (0.9%) had situational syncope, 13 (1.5%) had cardiogenic syncope, and 280 (31.5%) had unexplained syncope. Conclusions The data suggest that neurally-mediated syncope was the most common cause in children with syncope. POTS and VVS were the most common hemodynamic patterns of neurally-mediated syncope. PMID:21629199

  11. Materials on dies for pressure die casting

    Directory of Open Access Journals (Sweden)

    E. Ragan

    2012-01-01

    Full Text Available In the contribution the stress of die materials of thermal fatigue is defi ned and material life is derived theoretically and compared with the measured values. The important properties of the die materials as thermal conductivity, coeffi cient of thermal expansivity, modulus of elasticity and mechanical properties are described. Binding to it single die materials as carbon steels and chrome-tungsten steels are analyzed. As the perspective die material for pressure die casting of ferrous metals appears molybdenum with regard to advantageous properties.

  12. Under-ascertainment, under-reporting and timeliness of Iranian communicable disease surveillance system for zoonotic diseases.

    Science.gov (United States)

    Kazerooni, P A; Fararouei, M; Nejat, M; Akbarpoor, M; Sedaghat, Z

    2018-01-01

    The important steps in controlling infectious diseases are fast detection, proper treatment and on-time reporting of cases to the appropriate authorities. This study was conducted to evaluate the quality of Iranian communicable diseases surveillance system (CDSS) for zoonotic diseases in rural areas of Fars province (Iran's third largest province). The three most important evaluation indices of CDSS, namely under-ascertainment, under-reporting and timeliness, for the three most common zoonotic diseases were measured using independent data source obtained from door-to-door interviews and patients' medical records. Interviews were conducted with 48,771 households in rural areas of Fars province from April 2014 to March 2015. The medical and registration data were obtained from the CDSS and medical or health centres. Under-ascertainment, total under-reporting and timeliness (delay from the time of onset of symptoms to the time of visiting a medical or health centre, to the time of reporting visited cases to the highest level of CDSS) for leishmaniasis were 19.6%, 42.5% and 81.61 days (48.95 due to system delay), respectively. The corresponding indices for brucellosis were 0%, 41.8% and 56.5 days (22 due to system delay), respectively. For animal bite, the corresponding indices were 7.83%, 13.07% and less than 72 h, respectively (no system delay). Although the status of case reporting and timeliness of surveillance system in public sectors providing medical services are clearly better than those of the private sectors, the indices are far from the level needed by CDSS to be able to detect and handle epidemics on time. Training health personnel, especially physicians, from public and private sectors to secure their cooperation along with routine and indebt evaluation are necessary to improve CDSS in Iran. Copyright © 2017 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  13. The development of rail vehicles under the aspect of an increased availability; Die Entwicklung von Schienenfahrzeugen unter dem Aspekt einer erhoehten Verfuegbarkeit

    Energy Technology Data Exchange (ETDEWEB)

    Eberlein, M.; Hoefer, L. [Siemens AG, Erlangen (DE). Transportation Systems, Geschaeftsgebiet Triebzuege (Trains)

    2002-03-01

    This article is concentrated on the explanation of layout and design of rail vehicles used for long distance transport, but likewise applies to other areas of operation. A great innovation pressure and high demands on safety, availability and luxury features at a most reasonable price and a clearly increased availability force a maximum of efficiency and effectiveness from the system providers. Besides safety aspects operational availability is given highest relevance in the railway system. Availability, on the one side, decides on punctuality of a train, and on the other side it influences to a high degree the functionality of the railway overall system in the area. (orig.) [German] Grosser Innovationsdruck und hohe Anforderungen an Sicherheit, Zuverlaessigkeit und Komfort bei guenstigstem Preis und deutlich erhoehte Verfuegbarkeit erzwingen von den Systemanbietern und deren Lieferanten ein Maximum an Effizienz und Effektivitaet. Neben Sicherheitsaspekten kommt der betrieblichen Verfuegbarkeit die hoechste Relevanz im Eisenbahnwesen zu. Die Verfuegbarkeit entscheidet einerseits ueber die Puenktlichkeit eines Zuges, andererseits beeinflusst sie in hohem Masse die Funktionsfaehigkeit des Gesamtsystems Eisenbahn in der Flaeche. Man denke nur an Streckenprobleme - verursacht z.B. durch Zugausfall, Zwischenfaelle am Fahrweg - und deren mittelbare Folgen. Der Produktentstehungsprozess bei Siemens Transportation Systems ist auf diese Anforderungen ausgerichtet und von den Methoden des Zuverlaessigkeits-, Verfuegbarkeits- und Instandhaltbarkeits- und Sicherheitsengineerings (RAMS-Engineering: Reliability, Availability, Maintainability, Safety) nach DIN EN 50126 gepraegt. Dieser Beitrag konzentriert sich auf die Erlaeuterung der Auslegung von Schienenfahrzeugen des Fernverkehrs, gilt aber gleichermassen fuer andere Einsatzgebiete. (orig.)

  14. Die vrede van Münster / Westfale en die betekenis daarvan vir die ...

    African Journals Online (AJOL)

    In die Suid-Afrikaanse kerkgeskiedenis egter is die Vrede van Münster as epogmakende gebeure tot dusver nie net in die algemeen verwaarloos nie, maar boonop is die direkte verband tussen hierdie sentrale historiese baken aan die een kant en aan die ander kant die vestiging van die VOC se verversingspos aan die ...

  15. A. Selms DIE TEOLOGIE VAN DIE WOORD EN DIE FIGUUR VAN ...

    African Journals Online (AJOL)

    Test

    verhouding tussen God en mens van God af bepaal, maar die terminologie waarmee hy uitdrukking gee aan sy opvatting is die van die Axistoteliese metafisika, en met die terminologie dra hy die ontologiese grondgedagte van Aristoteles in die teologie in. Die sisteem van Aristoteles waarin die absolute en die relatiewe, ...

  16. Kinders in die erediens

    African Journals Online (AJOL)

    Roux neem in hierdie verband sterk standpunt in teen Jean Piaget en Ronald Goldman se teorieë oor kinderontwikkeling. Piaget oordeel dat kenmer- kende aspekte wat die kind se denke op 'n bepaalde stadium vertoon, die norm moet wees vir die bantering van die kind. Hy kategoriseer kinders volgens hulle intellektuele ...

  17. DIE SLAG VAN DOORNKRAAL

    African Journals Online (AJOL)

    Die slag van Doornkraal moet gesien word teen die agtergrond van die ..... saddled and tied to a food wagon. Steyn galloped off, leaving ..... great habit of his. He was proceeding to inspect the position, when he was shot through the neck. "64). Met sy aankoms op Doornkraal, het It kol De Lisle hom gehaas na die "rooi huis" ...

  18. Die Q gemeenskap as een van die grondtipes van die kerk in die ...

    African Journals Online (AJOL)

    p1243322

    sal veral aandag gee aan die term “koninkryk van God” (basileia tou theou) as moontlike aanduiding van “Christelike” denke, of anders gestel: aanduiding van die Q1 gemeenskap se simboliese universum (vgl hier onder), aangesien dit ook die enigste term in Q1 is waarmee die geloofsgemeenskap aangedui word.

  19. GODSBEELDE IN DIE LITURGIE

    African Journals Online (AJOL)

    15 Mei 2010 ... Biezeveld, de Boer, Brümmer, Muis. 2001; Brown 2006; Durand 2007). ... Wanneer sal hy weer in God se teenwoordigheid verskyn (vers 3)? Dié vraag is vol onsekerheid. (Schuman 2004:8). Sy onsekerheid ... God se volk en die enkeling in die geskiedenis het al die trou van God ervaar waarop die digter ...

  20. Die ontwikkeling van die bestuursmotiveringsvraelys (BMV

    Directory of Open Access Journals (Sweden)

    A. S. Engelbrecht

    1991-06-01

    Full Text Available The development of the Managerial Motivation Questionnaire (MMQ: Several criticisms of the psychometric suitability of existing measures of managerial motivation are reported in the literature. This study aimed at developing a new psychometrically sound instrument, the Managerial Motivation Questionnaire (MMQ. This was done on the basis of a comprehensive study of the literature on managerial motivation and the role-motivation theory. The preliminary MMQ was systematically shortened and refined until the final MMQ of 98 items was composed. This was based on social desirability and semantic appraisal, item analysis and factor analysis of the questionnaire. The results indicate that it was possible to develop a final MMQ that was relatively free of social desirability. It further demonstrated satsifactory internal consistencies on two samples (a = 0/90, N = 360; a = 0/91, N = 535, where all subscale items were found to be relatively pure measures of the isolated factors. Although some evidence was found providing support for the reliability of the MMQ, a need for further research on the construct validity of managerial motivation still exists. Opsomming In die literatuur word verskeie punte van kritiek teen die psigometriese geskiktheid van bestaande meetinstrumente van bestuursmotivering gerapporteer. Die doelstelling van hierdie studie was dus om aan die hand van die konseptuele omiyning van bestuursmotivering, en die rolmotiveringsteorie as algemene verwysingsraamwerk, 'n nuwe psigometries aanvaarbare meetinstrument, die Bestuursmotiveringsvraelys (BMV, te ontwikkel. Op grond van sosiale wenslikheids- en semantiese beoordeling, itemontleding en faktorontleding van die voorlopige BMV is die vraelys stelselmatig verkort en verfyn totdat die finale BMV van 98 items saamgestel is. Die resultate dui daarop dat hierdie studie wel daarin geslaag het om 'n finale BMV te ontwikkel wat relatief vry van sosiale wenslikheid is, bevredigende interne

  1. Implikasies van ontwikkelings in die leerstelling van goddelike genesing binne die Pinksterbeweging

    Directory of Open Access Journals (Sweden)

    Marius Nel

    2014-09-01

    Full Text Available Die Pinksterbeweging het met verloop van tyd sy begrip van die leer van goddelike genesing verander. Die veranderings is hoofsaaklik as gevolg van vorderings wat deur die mediese wetenskap gemaak is en die pinksterteologie moes opnuut die verhouding tussen versoening en heling definieer. Die veranderings word in terme van die geskiedenis van die wit afdeling van die Apostoliese Geloof Sending van Suid-Afrika (AGS, die grootste pinksterdenominasie in Suid-Afrika, beskryf. Dit dien tot ’n groot mate as verteenwoordigend van veranderings in die res van die AGS, maar ook van die Pinksterbeweging as sodanig. Die ontleding toon dat die veranderde houding teenoor die gebruik van medisyne en inenting sowel as mediese prosedures soos operasies pinksterkerke uiteindelik dwing om toegewings in sy genesingsbediening te maak wat aan sy Skrifbeskouing verwant is. Dat die kerk veranderings aanbring in ’n belangrike leerstelling soos dié van goddelike genesing, hou belangrike implikasies vir die kerk in. Die implikasies hou verband met die wyse waarop die pinkstermense die Bybel lees en benut en dit noodsaak die Pinksterbeweging om ook oor ander leerstellings na te dink wat uitdagings daaraan stel, byvoorbeeld die eskatologie en ekklesiologie. Implications of developments in die doctrine of divine healing in die Pentecostal movement. The Pentecostal movement changed over time its understanding of the doctrine of divine healing. These changes are mainly in the attitude towards the advances made by medical science and reflected in the way pentecostal theology defined the relation between atonement and healing. The changes are described in terms of the history of the white division of the Apostolic Faith Mission of South Africa (AFM, the largest pentecostal denomination within South Africa. It serves to a large extent as representative of the changes in the AFM, but also the Pentecostal movement per se. The analysis shows that the changed attitude towards the

  2. Die Universiteit en beroepsopleidng

    Directory of Open Access Journals (Sweden)

    J. G. Garbers

    1980-03-01

    Full Text Available By elke gradedag is daar by die betrokkenes die neiging om terug te dink aan die pad wat hul bekroning voorafgegaan het. Diegene wat hulle met die volwassewording besig hou, weet maar al te goed aan hoeveel voorwaardes oor baie jare voldoen moes word om ’n jongmens by hier­ die mylpaal te kon bring. Aan baie kwaliteitseise in die opvoeding moes voldoen word. Veel meer as voeding, versorging en die voorsien van middele deur die ouers was nodig. Ook ’n bepaalde kwaliteit kontak en gesprekvoering met mekaar en wedersydse aanvaarding en positiewe verwagtings van mekaar was nodig. Ge- leenthede moes voorsien en benut word, selfstandigheid moes deur die ouers toe- gelaat en deur die kinders verdien word, ens.

  3. Thomas Erastus oor die struktuur van die gemeenskap'^

    African Journals Online (AJOL)

    staan sonder die wil of bevel van die vors nie. In die Zurichse hervorming het Zwingli, die onafhanklike tydgenoot van Luther, grotendeels dieselfde opvattings gehuldig en word die hele gemeenskap, onder die leiding van die burgerlike owerheid, as civitas. Dei waardeer. In 'n sekere sin kan gesê word dat by Zwingli die.

  4. e .Kuraioriufn. DIE W ETENSKAPLIKE BETEKENIS VAN DIE W ERK

    African Journals Online (AJOL)

    Test

    ENGELBRECHT ver antwoordelik vir die Ou-Testamentiese vakke en Hebreeus. Die aan stelling van 'n derde professor het noodsaaklik geword, want dit sou. 85 .... De .Spreuken ran 5a/o?no omvat die nuwe vertaling en die ekse gese van die eerste 24 hoofstukke van die Spreukeboek. Die geskoold- heid in die Semitiese ...

  5. Prediking aan die hand van die metafoor van fiksieskryf

    African Journals Online (AJOL)

    p1243322

    HTS 64(3) 2008 siening van die self en waarheid. In die pre-moderne paradigma kan die dominante metafoor verstaan word aan die hand van 'n spieël wat die lig uit 'n transendente oorsprong weerkaats, terwyl die moderne paradigma uitgedruk word met die metafoor van 'n lamp wat 'n eie, oorspronklike lig binne die self.

  6. Die sestienpersoonlikheidsfaktorvraelys as hulpmiddel by die takseersentrum

    Directory of Open Access Journals (Sweden)

    J. C. D. Augustyn

    1988-05-01

    Full Text Available The 16PF Personality Test as an aid to the assessment centre Assessment centres still remains costly and thime consuming. This study investigates the reduction of time and costs by the use of the 16 PF Personality Test as a method for measuring management dimensions. Promising results were obtained with a relatively small sample for the prediction of initiative and perseverance. Significant multiple correlations were also found for three criteria of management success. Further research may establish the use of the 16 PF as an aid to management assessment and thereby reduce the costs and time involved in assessment centres. Opsomming Takseersentrums se grootste probleem is gelee in die koste en tyd wat dit behels. Hierdie studie ondersoek die moontlikheid om beide te verminder deur die aanwending van die 16 PF Persoonlikheidsvraelys vir die meting van bestuursdimensies. Belowende resultate is met 'n relatiewe klein steekproef bevind ten opsigte van die voorspelling van inisiatiefen deursettingsvermoe. Beduidende meervoudige korrelasies is ook ten opsigte van drie kriteria van bestuursukses bevind. Verdere navorsing kan die gebruik van die 16 PF as hulpmiddel by bestuursevaluering vestig en sodoende die tydsduur en koste van takseersentrums verminder.

  7. Die kerk: 'n Verenigende of verdelende faktor in die ontwikkeling ...

    African Journals Online (AJOL)

    As 'n mens in die spieël kyk, sien hy iets wat 'n watjie méér is as die engele, bes moontlik 'n god. En dis waar die kerk in die spel kom. 1. DIE TAAK VAN DIE KERK. Sedert die dae van die Ou Testament is dit een van die mees basiese take van die. 'kerk' om aan mense te verkondig dat daar net één God is, dat hulle self ...

  8. DIE GRONDSTEENLEGGING VAN DIE TWEEDE TEMPEL. 1. D:e ...

    African Journals Online (AJOL)

    Test

    In die boek van die profesieë van Sagaria is daar twee perikope wat oor die tempelbou handel, H. 4:6b-10a en H. 8:9-13. Die eersge- noemde gedeelte is 'n onderbreking van die vyfde naggesig, dié van die. ') Die vertrek uit Babei het waarskynlik in die voorjaar, omstreej^ April plaasgevind, die aankoms in Palestina in die ...

  9. Skrifberoep in die vorming van etiese uitsprake, Deel 1: ’n Etiese verstaan van die vrou in die Bybel

    Directory of Open Access Journals (Sweden)

    Adriaan L. Rheeder

    2012-11-01

    Full Text Available Na 30 jaar kon die grammaties-historiese metode van Skrifondersoek nie daarin slaag om die etiese probleem van die vrou in die kerklike ampte (en homoseksualiteit in die GKSA op te los nie. Hierdie metode kan na alle waarskynlikheid nie meer as die enigste verklaringsmetode gebruik word nie en moet deur ander uitgangspunte aangevul word. In hierdie artikel word twee hermeneutiese uitgangspunte bespreek wat saam met die grammaties-historiese metode in die vertolking van die Skrif gebruik kan word. Hierdie hermeneutiese uitgangspunte sal gedemonstreer word in ‘n bespreking oor die etiese verstaan van die vrou in die Bybel, spesifiek soos dit op die vrou in kerklike ampte toegepas word. In aansluiting by laasgenoemde twee vertrekpunte word in ’n opvolgartikel ’n verdere drie hermeneutiese vertrekpunte behandel. Die twee hermeneutiese vertrekpunte wat in hierdie artikel behandel word, staan as reëldoelwit en analogie bekend. Die eerste hermeneutiese vertrekpunt gaan uit van die veronderstelling dat die reëldoelwit van ’n teks swaarder weeg as die teks self, terwyl analogie van die veronderstelling uitgaan dat analogie as beredenering ’n aanvaarbare en noodsaaklike vertrekpunt is. Bogenoemde hermeneutiese vertrekpunte (vyf in totaal is op twee aannames gegrond. Ten eerste word aanvaar dat die Bybel, alhoewel ’n goddelike boek, ’n besliste kreatuurlike kant het wat in die vertolking daarvan in ag geneem moet word. Tweedens word geredeneer dat die Skrif nie ’n  teologiese boek is nie, wat beteken dat gelowiges in etiese sake waaroor daar twee verstaansmoontlikhede bestaan, die reg gegun moet word om self die Skrif te vertolk. Daar word tot die  gevolgtrekking gekom dat ’n etiese verstaan van die vrou daartoe moet lei dat die vrou as gelykwaardig aan die man beskou en behandel moet word, met die gevolg dat die vrou tot alle ampte in die kerk toegelaat moet word. Appeal to Scripture in the formation of ethical judgments, Part 1: An

  10. Newcastle disease virus in Madagascar: identification of an original genotype possibly deriving from a died out ancestor of genotype IV.

    Science.gov (United States)

    Maminiaina, Olivier F; Gil, Patricia; Briand, François-Xavier; Albina, Emmanuel; Keita, Djénéba; Andriamanivo, Harentsoaniaina Rasamoelina; Chevalier, Véronique; Lancelot, Renaud; Martinez, Dominique; Rakotondravao, R; Rajaonarison, Jean-Joseph; Koko, M; Andriantsimahavandy, Abel A; Jestin, Véronique; Servan de Almeida, Renata

    2010-11-15

    In Madagascar, Newcastle disease (ND) has become enzootic after the first documented epizootics in 1946, with recurrent annual outbreaks causing mortality up to 40%. Four ND viruses recently isolated in Madagascar were genotypically and pathotypically characterised. By phylogenetic inference based on the F and HN genes, and also full-genome sequence analyses, the NDV Malagasy isolates form a cluster distant enough to constitute a new genotype hereby proposed as genotype XI. This new genotype is presumably deriving from an ancestor close to genotype IV introduced in the island probably more than 50 years ago. Our data show also that all the previously described neutralising epitopes are conserved between Malagasy and vaccine strains. However, the potential implication in vaccination failures of specific amino acid substitutions predominantly found on surface-exposed epitopes of F and HN proteins is discussed.

  11. Sturge-Weber disease: Diagnostic imaging and neuropathology. Die Sturge-Weber-Erkrankung: Bildgebende Diagnostik in bezug zur Neuropathologie

    Energy Technology Data Exchange (ETDEWEB)

    Henkes, H.; Huber, G.; Piepgras, U. (Universitaet des Saarlandes, Homburg/Saar (Germany, F.R.). Abt. fuer Neuroradiologie); Bittner, R. (Freie Univ. Berlin (Germany, F.R.). Strahlenklinik und Poliklinik); Sperner, J. (Freie Univ. Berlin (Germany, F.R.). Abt. fuer Neuropaediatrie); Heye, N. (Freie Univ. Berlin (Germany, F.R.). Inst. fuer Neuropathologie); Bassir, C. (Freie Univ. Berlin (Germany, F.R.). Abt. fuer Paediatrische Radiologie)

    1991-06-01

    Clinical presentation of a child with port-wine stain and seizures leads to the suspicion of Sturge-Weber disease (SWD). This diagnosis can be confirmed by the detection of a meningeal angiomatosis. In rare cases, early detection of meningeal pathology by ultrasound has been reported. Key findings are brain atrophy, gyriform cortical calcifications demonstrated by skull radiographs after the first year of life or earlier by cranial CT, and dys- or aplasia of the deep cerebral veins on angiography. Radionuclide imaging shows focal or diffuse tracer accumulation over the affected brain regions. MR demonstrates an abnormal appearance of the affected meninges, especially thickening and pathologically increased signal intensity after Gd-DTPA application. This, in association with the demonstration of abnormal enhancement in deep medullary veins, is the most characteristic finding. Contrast-enhanced MR allows early and non-invasive diagnosis of SWD, mainly by revealing leptomeningeal angiomatosis and abnormal venous vessels. (orig.).

  12. Newcastle disease virus in Madagascar: identification of an original genotype possibly deriving from a died out ancestor of genotype IV.

    Directory of Open Access Journals (Sweden)

    Olivier F Maminiaina

    Full Text Available In Madagascar, Newcastle disease (ND has become enzootic after the first documented epizootics in 1946, with recurrent annual outbreaks causing mortality up to 40%. Four ND viruses recently isolated in Madagascar were genotypically and pathotypically characterised. By phylogenetic inference based on the F and HN genes, and also full-genome sequence analyses, the NDV Malagasy isolates form a cluster distant enough to constitute a new genotype hereby proposed as genotype XI. This new genotype is presumably deriving from an ancestor close to genotype IV introduced in the island probably more than 50 years ago. Our data show also that all the previously described neutralising epitopes are conserved between Malagasy and vaccine strains. However, the potential implication in vaccination failures of specific amino acid substitutions predominantly found on surface-exposed epitopes of F and HN proteins is discussed.

  13. Social contact networks and disease eradicability under voluntary vaccination.

    Directory of Open Access Journals (Sweden)

    Ana Perisic

    2009-02-01

    Full Text Available Certain theories suggest that it should be difficult or impossible to eradicate a vaccine-preventable disease under voluntary vaccination: Herd immunity implies that the individual incentive to vaccinate disappears at high coverage levels. Historically, there have been examples of declining coverage for vaccines, such as MMR vaccine and whole-cell pertussis vaccine, that are consistent with this theory. On the other hand, smallpox was globally eradicated by 1980 despite voluntary vaccination policies in many jurisdictions. Previous modeling studies of the interplay between disease dynamics and individual vaccinating behavior have assumed that infection is transmitted in a homogeneously mixing population. By comparison, here we simulate transmission of a vaccine-preventable SEIR infection through a random, static contact network. Individuals choose whether to vaccinate based on infection risks from neighbors, and based on vaccine risks. When neighborhood size is small, rational vaccinating behavior results in rapid containment of the infection through voluntary ring vaccination. As neighborhood size increases (while the average force of infection is held constant, a threshold is reached beyond which the infection can break through partially vaccinated rings, percolating through the whole population and resulting in considerable epidemic final sizes and a large number vaccinated. The former outcome represents convergence between individually and socially optimal outcomes, whereas the latter represents their divergence, as observed in most models of individual vaccinating behavior that assume homogeneous mixing. Similar effects are observed in an extended model using smallpox-specific natural history and transmissibility assumptions. This work illustrates the significant qualitative differences between behavior-infection dynamics in discrete contact-structured populations versus continuous unstructured populations. This work also shows how disease

  14. Die etiek van Luther

    Directory of Open Access Journals (Sweden)

    J. H. van Wyk

    1983-06-01

    Full Text Available Dink ons aan die etiek van Luther dan spring onmiddellik ’n paar boeiende uitsprake van hom na vore soos o.a. dat Christene vanuit die gemeenskap met Christus nuwe dekaloë moet maak wat helderder as die van Moses kan wees, of dat ons in bepaalde sin vir ons naaste ’n Christus moet word. Die bydrae van Luther 'tot die Christelike etiek is sonder twyfel van groot betekenis en die bestudering daarvan die moeite werd. Luther is geprys as rewolusionêr en verguis as konserwatis, hy is geëer as iemand wat weer die ware be­tekenis van godsdiens ontdek het toe die lewe vervloei het in etiek. Of dit egter korrek is om sy etiek as konserwatief te tipeer, soos White doen, moet betwyfel word.

  15. Bone disease in patients with chronic kidney disease under conservative management

    Directory of Open Access Journals (Sweden)

    Carlos Perez Gomes

    Full Text Available CONTEXT AND OBJECTIVE: Few studies have focused on bone disease in patients with chronic kidney disease under conservative treatment. The objective was to evaluate bone disease in patients with chronic kidney disease. DESIGN AND SETTING: Case series, at the Nephrology Division, Hospital Universitário Pedro Ernesto. METHODS: 131 patients with creatinine clearance from 10 to 60 ml/min/1.73 m² were followed up for at least one year. Serum creatinine, albumin, calcium, phosphorus, alkaline phosphatase, total CO2 (tCO2, intact parathyroid hormone (iPTH, and alkaline phosphatase were measured. Creatinine clearance was calculated from 24-hour urine creatinine measurements and protein ingestion estimates from urea assays. RESULTS: Patients presenting creatinine clearance 144 pg/ml showed osteitis fibrosa (4, mild lesion (4 and high turnover (1. CONCLUSION: The present data suggest the importance of early control for iPTH and metabolic acidosis, among patients under conservative management for chronic kidney disease, in order to prevent complications related to bone disease.

  16. DIE OUTESTAMENTIESE LEER AANGAANDE DIE MENS AS ...

    African Journals Online (AJOL)

    Test

    verdwyn s o o s rook". Meer voorbeetde gee die genoemde grammatikas. ') Hierdie opvatting van be vind ons bv. in die Leidsche Vertaling 1899, by JoH. H EH N , Zum TermiïiMS ,,BiM Qottes" in Festschrift Sachau, 1915, BÖ H L in TeÍMt en Uitieg,.

  17. Evalueringskriteria en die interaksie tussen die leksikografieteorie ...

    African Journals Online (AJOL)

    Ten slotte word hierdie probleem toegelig aan die hand van die ontwerpkenmerke van WAT Deel XIV. ... Nielsen 2006, 2009 and Swanepoel 2008, 2013) is that reviews only provide an analysis and description of the design features of dictionaries and not also an evaluation based on a set of clearly formulated and ...

  18. die pers as bron oor die geskiedenis van die eerste vrydeidsoorlog

    African Journals Online (AJOL)

    Die doel van hierdie artikel is om die redes vir die publikasie van verdraaiings in die koerante van destyds te ondersoek en vervolgens aan Ie dui waarom die pers nie as enigste bron gebruik kan word om die geskiedenis van die Eerste. Vryheidsoorlog te boekstaaf nie. Dit is nie moontlik om al die koerante wat gedurende ...

  19. die self-sny fenomeen onder jongmense: perspektiewe vanuit die ...

    African Journals Online (AJOL)

    word eerstens gefokus op redes vir die toename van die fenomeen van self- sny. Daarna kom die belangrikheid van emosies, die dinamika van die proses self asook 'n behandelingsprogram aan die orde. Ten slotte word 'n aantal pastorale perspektiewe aan die orde gestel asook riglyne ten einde 'n terugval te voorkom.

  20. Die plek van Empedokles in die metafisies-mistieke tradisie

    African Journals Online (AJOL)

    p1243322

    bodhisatva-, miskien selfs buddha-begrip. Die verskille tussen die twee stelsels is ewe opvallend. 'n Interessante vergelykingspunt met spesifiek die Boeddhisme is byvoorbeeld die relasie tussen liefde en twis (haat). By die vroeë Boeddhisme draai die konvensionele mikro-kosmiese (menslike) lewensproses om die drie ...

  1. DIE KONINGSBEDE AS ELEMENT IN DIE KRONINGSRITUEEL. By ...

    African Journals Online (AJOL)

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    3:5 en II Kron. 1 :7. Wat die rede is, waarom die Afrikaanse vertalers hier 'n ander woord gebruik het as in Kon. en Kron., bly onduidelik; die werkwoord sya'af word op sestien verskillende maniere deur hulle weergegee. Die inhoud van die koningsbede, waarop Ps. 2:8 sinspeel is die opperheerskappy oor die omwonende ...

  2. die suid-afrikaanse oorlogsekonomie gedurende die tweede ...

    African Journals Online (AJOL)

    Amerikaanse leer in Europa teen die einde van die jaar en die begin van 1945. Die Amerikaanse veldtog in die Stille Oseaan het geweldige laai- ruimte in beslag geneem. 'n Aansienlike kwota was ook voortdurend betrokke by die vervoer van noodsaaklike voorrade na Brittanje. Tot die tweede helfte van 1941, dws vir ...

  3. P. J. N. Smal, Die Universalisme in die Psalms. Academisch ...

    African Journals Online (AJOL)

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    dat die historiese element in Israel se Godsopenbaring en daarmee die insig in sy betekenis te kort gedoen word. Die betekenis van die studie vir die historia revelationis is daardeur gering; as duidelike „tydlose” sistematisering van Outestamentiese gegewens oor die betrokke onder- werpe, soos die laaste hoofstuk, bl.

  4. Patristiek en die studie van die Nuwe Testament

    African Journals Online (AJOL)

    Die titel van die reeks is Biblia Patristica. Die eerste volume dek die patristiese literatuur tot by Tertullianus en Klemens van Aleksan- drië. Dit bevat 28 000 verwysings. Die tweede volume bevat 22 000 verwysings en dek die derde eeu, uitgesonderd Origenes. Die omvang- rykheid van hierdie projek word duidelik wanneer ...

  5. Navorsing op die gebied van die sosiale wetenskappe*

    Directory of Open Access Journals (Sweden)

    P. M. Robbertse

    1958-03-01

    Full Text Available In Hollands is die woord scientia vertaal met wetenskap, wat sowel die natuur- as die geesteswetenskappe insluit, waardeur die woordsy oorspronklike betekenis behou. Die neiging bestaan om die Engels science met wetenskap in Afrikaans te vertaal, waarmee dan eintlik die natuurwetenskap bedoel word.

  6. Die geskiedenis van die saw gedenkteken te Fort Klapperkop ...

    African Journals Online (AJOL)

    Die SAW Gedenkteken se lotgevalle is nou verbonde aan die van die. Militere Museum Fort Klapperkop aangesien die Gedenkteken op die terrein van Fort Klapperkop opgerig is. Weens rasionalisasie is die voortbestaan van Fort Klapperkop Museum onseker. Dit plaas ongetwyfeld dan ook 'n vraagteken agter die ...

  7. Mechanisms Underlying HIV-Associated Noninfectious Lung Disease.

    Science.gov (United States)

    Presti, Rachel M; Flores, Sonia C; Palmer, Brent E; Atkinson, Jeffrey J; Lesko, Catherine R; Lau, Bryan; Fontenot, Andrew P; Roman, Jesse; McDyer, John F; Twigg, Homer L

    2017-11-01

    Pulmonary disease remains a primary source of morbidity and mortality in persons living with HIV (PLWH), although the advent of potent combination antiretroviral therapy has resulted in a shift from predominantly infectious to noninfectious pulmonary complications. PLWH are at high risk for COPD, pulmonary hypertension, and lung cancer even in the era of combination antiretroviral therapy. The underlying mechanisms of this are incompletely understood, but recent research in both human and animal models suggests that oxidative stress, expression of matrix metalloproteinases, and genetic instability may result in lung damage, which predisposes PLWH to these conditions. Some of the factors that drive these processes include tobacco and other substance use, direct HIV infection and expression of specific HIV proteins, inflammation, and shifts in the microbiome toward pathogenic and opportunistic organisms. Further studies are needed to understand the relative importance of these factors to the development of lung disease in PLWH. Copyright © 2017 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

  8. Histiocytoid Sweet Syndrome in a Child without Underlying Systemic Disease.

    Science.gov (United States)

    Yeom, Seung Dohn; Ko, Hye Soo; Moon, Jong Hyuk; Kang, Min Ji; Byun, Ji Won; Choi, Gwang Seong; Shin, Jeonghyun

    2017-10-01

    Sweet syndrome (acute, febrile, neutrophilic dermatosis) is characterized by the acute onset of an eruption of painful nodules or erythematous or violaceous plaques on the limbs, face and neck. These symptoms are accompanied by fever. The diagnostic features include histopathological findings of dermal neutrophilic infiltration without leukocytoclastic vasculitis or peripheral blood leukocytosis. Sweet syndrome is associated with infection, malignancies, autoimmune disease, pregnancy, and drugs. Patients with Sweet syndrome demonstrate a complete and rapid response to systemic steroid administration. Recently, a distinct variant of Sweet syndrome was reported, termed "histiocytoid Sweet syndrome", in which the infiltration of myeloperoxidase-positive histiocytoid mononuclear cells are observed (in contrast to the infiltration of neutrophils). The other clinical features are similar to those of classic Sweet syndrome. Pediatric Sweet syndrome is uncommon, and the histiocytoid type is even rarer. To date, four cases of histiocytoid Sweet syndrome have been reported in children. Herein, we describe a case of histiocytoid Sweet syndrome in an otherwise healthy 10-year-old boy with no underlying systemic disease in whom non-steroidal, anti-inflammatory drug treatment was successful.

  9. Transcriptional regulatory networks underlying gene expression changes in Huntington's disease.

    Science.gov (United States)

    Ament, Seth A; Pearl, Jocelynn R; Cantle, Jeffrey P; Bragg, Robert M; Skene, Peter J; Coffey, Sydney R; Bergey, Dani E; Wheeler, Vanessa C; MacDonald, Marcy E; Baliga, Nitin S; Rosinski, Jim; Hood, Leroy E; Carroll, Jeffrey B; Price, Nathan D

    2018-03-26

    Transcriptional changes occur presymptomatically and throughout Huntington's disease (HD), motivating the study of transcriptional regulatory networks (TRNs) in HD We reconstructed a genome-scale model for the target genes of 718 transcription factors (TFs) in the mouse striatum by integrating a model of genomic binding sites with transcriptome profiling of striatal tissue from HD mouse models. We identified 48 differentially expressed TF-target gene modules associated with age- and CAG repeat length-dependent gene expression changes in Htt CAG knock-in mouse striatum and replicated many of these associations in independent transcriptomic and proteomic datasets. Thirteen of 48 of these predicted TF-target gene modules were also differentially expressed in striatal tissue from human disease. We experimentally validated a specific model prediction that SMAD3 regulates HD-related gene expression changes using chromatin immunoprecipitation and deep sequencing (ChIP-seq) of mouse striatum. We found CAG repeat length-dependent changes in the genomic occupancy of SMAD3 and confirmed our model's prediction that many SMAD3 target genes are downregulated early in HD. © 2018 The Authors. Published under the terms of the CC BY 4.0 license.

  10. Dying with dignity.

    Science.gov (United States)

    Madan, T N

    1992-08-01

    Death is a theme of central importance in all cultures, but the manner in which it is interpreted varies from society to society. Even so, traditional cultures, including Christian, Hindu and Jain religious traditions, exhibited a positive attitude to death and did not look upon it in a dualistic framework of good vs bad, or desirable vs undesirable. Nor was pessimism the dominant mood in their thinking about death itself. A fundamental paradigm shift occurred in the West in the eighteenth century when death was desacralized and transformed into a secular event amenable to human manipulation. From those early beginnings, dying and death have been thoroughly medicalized and brought under the purview of high technology in the twentieth century. Once death is seen as a problem for professional management, the hospital displaces the home, and specialists with different kinds and degrees of expertise take over from the family. Everyday speech and the religious idiom yield place to medical jargon. The subject (an ageing, sick or dying person) becomes the object of this make-believe yet real world. As the object of others' professional control, he or she loses the freedom of self-assessment, expression and choice. Or, he or she may be expected to choose when no longer able to do so. Thus, not only freedom but dignity also is lost, and lawyers join doctors in crisis manipulation and perpetuation. Although the modern medical culture has originated in the West, it has gradually spread to all parts of the world, subjugating other kinds of medical knowledge and other attitudes to dying and death.(ABSTRACT TRUNCATED AT 250 WORDS)

  11. DIE ONSTERFLIKHEID VAN DIE MENSLIKE SIEL') Daar is geen ...

    African Journals Online (AJOL)

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    die mag van die Bose wat dit as 'n usurpator wederregtelik hom toegeëien het. Christus sê dan ook in Johannes 6 vers 47 dat wie in. Hom glo, d.w.s. wie in Hom ingewortel en ingeplant is, het die ewige lewe, besit die onsterflikheid. Die dood is die gevolg van die wegbreking van God, en die ewige lewe is die gevolg van ...

  12. Packaged die heater

    Science.gov (United States)

    Spielberger, Richard; Ohme, Bruce Walker; Jensen, Ronald J.

    2011-06-21

    A heater for heating packaged die for burn-in and heat testing is described. The heater may be a ceramic-type heater with a metal filament. The heater may be incorporated into the integrated circuit package as an additional ceramic layer of the package, or may be an external heater placed in contact with the package to heat the die. Many different types of integrated circuit packages may be accommodated. The method provides increased energy efficiency for heating the die while reducing temperature stresses on testing equipment. The method allows the use of multiple heaters to heat die to different temperatures. Faulty die may be heated to weaken die attach material to facilitate removal of the die. The heater filament or a separate temperature thermistor located in the package may be used to accurately measure die temperature.

  13. Die radio in Afrika

    Directory of Open Access Journals (Sweden)

    S. de Villiers

    1966-03-01

    Full Text Available Omvang van radio-uitsendings in en na Afrika. — Redes vir die versnelde tempo van uitbreiding. — Radio as die geskikste massa-kommunikasiemiddel vir Afrika. — Faktore wat die verspreiding bemoeilik. — Skouspelagtige toename in luistertalle.Toe Plinius, wat in die jaar 79 oorlede is, in sy „Historia Naturalis” verklaar het dat daar altyd iets nuuts uit Afrika afkomstig is, kon hy nouliks voorsien het dat die „iets" negentien eeue later in die lug sou setel wat hierdie reuse-vasteland oorspan — ’n Babelse spraakverwarring en ’n ongekende, verbete woorde-oorlog in die etergolwe, onder meer daarop bereken om die harte en hoofde van derduisendes te verower.

  14. Die Bedeutung des Internet

    OpenAIRE

    Picot, Arnold; Neuburger, Rahild; Prinz, Aloys; Esser, Josef; Hoeren, Thomas

    2000-01-01

    Gegenwärtig vollzieht sich eine Wandlung von Wirtschaft und Gesellschaft durch das Internet. Sind die hohen Erwartungen, die von vielen an das Internet geknüpft werden, berechtigt? Was vermag das Internet zu leisten?

  15. Die Tempelrolle und die Struktureigenschaften des Kollagens

    OpenAIRE

    Schütz, Roman

    2016-01-01

    Die „Schriftrollen vom Toten Meer“ stoßen seit ihrer Entdeckung Mitte des letzten Jahrhunderts bei den Religionshistorikern und in der breiten Öffentlichkeit auf großes Interesse. Sie stammen aus der Zeit der Zweiten Tempelperiode - der Wiege des Christentums und dem Vorabend der Zerstörung des Tempels von Jerusalem durch die Römer. Diese Ereignisse haben den weiteren Verlauf der Menschheitsgeschichte entscheidend mitgeprägt. Dem Text der Rollen hat die Forschung sehr viel Aufmerksamkeit ...

  16. Die humanistiese mensbeeld

    African Journals Online (AJOL)

    Liberalisme-kapitalisme vanuit die denke van Adam Smith (1723-. 1790), demokratiese-sosialisme vanuit die denke van Jean Jacques Rousseau (1712-. 1778), en Marxisme-kommunisme vanuit die denke van Karl Marx (1818-1883). In elkeen van hierdie ideologiese strominge bestaan 'n mensbeeld soos dit bepaal.

  17. Independent Role of Underlying Kidney Disease on Renal Prognosis of Patients with Chronic Kidney Disease under Nephrology Care.

    Directory of Open Access Journals (Sweden)

    Luca De Nicola

    Full Text Available Primary kidney disease is suggested to affect renal prognosis of CKD patients; however, whether nephrology care modifies this association is unknown. We studied patients with CKD stage I-IV treated in a renal clinic and with established diagnosis of CKD cause to evaluate whether the risk of renal event (composite of end-stage renal disease and eGFR decline ≥ 40% linked to the specific diagnosis is modified by the achievement or maintenance in the first year of nephrology care of therapeutic goals for hypertension (BP ≤ 130/80 mmHg in patients with proteinuria ≥ 1 50 mg/24h and/or diabetes and ≤ 140/90 in those with proteinuria <150 mg/24h and without diabetes anemia (hemoglobin, Hb ≥ 11 g/dL, and proteinuria (≤ 0.5 g/24h. Survival analysis started after first year of nephrology care. We studied 729 patients (age 64 ± 15 y; males 59.1%; diabetes 34.7%; cardiovascular disease (CVD 44.9%; hypertensive nephropathy, HTN 53.8%; glomerulonephritis, GN 17.3%; diabetic nephropathy, DN 15.9%; tubule-interstitial nephropathy, TIN 9.5%; polycystic kidney disease, PKD 3.6%. During first year of Nephrology care, therapy was overall intensified in most patients and prevalence of main therapeutic goals generally improved. During subsequent follow up (median 3.3 years, IQR 1.9-5.1, 163 renal events occurred. Cox analysis disclosed a higher risk for PKD (Hazard Ratio 5.46, 95% Confidence Intervals 2.28-10.6 and DN (1.28,2.99-3.05, versus HTN (reference, independently of age, gender, CVD, BMI, eGFR or CKD stage, use of RAS inhibitors and achievement or maintenance in the first year of nephrology care of each of the three main therapeutic goals. No interaction was found on the risk of CKD progression between diagnostic categories and month-12 eGFR (P=0.737, as with control of BP (P=0.374, Hb (P=0.248 or proteinuria (P=0.590. Therefore, in CKD patients under nephrology care, diagnosis of kidney disease should be considered in conjunction with the main

  18. Independent Role of Underlying Kidney Disease on Renal Prognosis of Patients with Chronic Kidney Disease under Nephrology Care.

    Science.gov (United States)

    De Nicola, Luca; Provenzano, Michele; Chiodini, Paolo; Borrelli, Silvio; Garofalo, Carlo; Pacilio, Mario; Liberti, Maria Elena; Sagliocca, Adelia; Conte, Giuseppe; Minutolo, Roberto

    2015-01-01

    Primary kidney disease is suggested to affect renal prognosis of CKD patients; however, whether nephrology care modifies this association is unknown. We studied patients with CKD stage I-IV treated in a renal clinic and with established diagnosis of CKD cause to evaluate whether the risk of renal event (composite of end-stage renal disease and eGFR decline ≥ 40%) linked to the specific diagnosis is modified by the achievement or maintenance in the first year of nephrology care of therapeutic goals for hypertension (BP ≤ 130/80 mmHg in patients with proteinuria ≥ 1 50 mg/24h and/or diabetes and ≤ 140/90 in those with proteinuria nephrology care. We studied 729 patients (age 64 ± 15 y; males 59.1%; diabetes 34.7%; cardiovascular disease (CVD) 44.9%; hypertensive nephropathy, HTN 53.8%; glomerulonephritis, GN 17.3%; diabetic nephropathy, DN 15.9%; tubule-interstitial nephropathy, TIN 9.5%; polycystic kidney disease, PKD 3.6%). During first year of Nephrology care, therapy was overall intensified in most patients and prevalence of main therapeutic goals generally improved. During subsequent follow up (median 3.3 years, IQR 1.9-5.1), 163 renal events occurred. Cox analysis disclosed a higher risk for PKD (Hazard Ratio 5.46, 95% Confidence Intervals 2.28-10.6) and DN (1.28,2.99-3.05), versus HTN (reference), independently of age, gender, CVD, BMI, eGFR or CKD stage, use of RAS inhibitors and achievement or maintenance in the first year of nephrology care of each of the three main therapeutic goals. No interaction was found on the risk of CKD progression between diagnostic categories and month-12 eGFR (P=0.737), as with control of BP (P=0.374), Hb (P=0.248) or proteinuria (P=0.590). Therefore, in CKD patients under nephrology care, diagnosis of kidney disease should be considered in conjunction with the main risk factors to refine renal risk stratification.

  19. Diagnostics for diseases of the gallbladder and biliary tract from the viewpoint of the internist and surgeon. Demands made on radiological diagnostics; Diagnostik von Erkrankungen der Gallenblase und - Wege aus Sicht des Internisten und Chirurgen. Anforderungen an die radiologische Diagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Reimann, F.M. [Krankenhaus Salem, Heidelberg (Germany); Friess, H. [Krankenhaus Salem, Heidelberg (Germany); Universitaetsklinikum Heidelberg (Germany). Abteilung fuer Allgemein-, Viszeral- und Unfallchirurgie

    2005-11-01

    Jaundice and colic pain of the right upper quadrant are the main symptoms of biliary diseases. Gallstone-related diseases often lead to hospital admission. The evaluation of a patient with biliary symptoms requires a combination of history taking, physical examination, laboratory analysis, and imaging modalities. A high-quality magnetic resonance imaging (MRI) or computed tomography (CT) scan is usually sufficient to evaluate a patient with painless jaundice. Ultrasonography is helpful as an initial screening test to guide the diagnostic work-up. Invasive methods (e.g., ERCP) are mainly used for palliation of patients with incurable disease. (orig.) [German] Erkrankungen der Gallenwege manifestieren sich mit den beiden Kardinalsymptomen Ikterus und kolikartigen rechtsseitigen Oberbauchschmerzen. Die durch Gallensteine verursachten Beschwerden und Erkrankungen zaehlen zu den haeufigsten gastroenterologischen Krankheitsbildern, die eine Klinikaufnahme erfordern. Die Abklaerung eines Patienten mit biliaeren Symptomen erfolgt durch eine Kombination von Anamnese, Medikamentenanamnese, koerperlicher Untersuchung, Laboranalysen und bildgebenden Verfahren. Bei Patienten mit malignen Tumoren im Bereich der ableitenden Gallenwege reichen in vielen Faellen Computertomographie (CT) oder Magnetresonanztomographie (MRT) zur Abklaerung des schmerzlosen Ikterus aus, um Therapieentscheidungen fuer den Patienten zu faellen. Der Ultraschall ist fuer die Planung der weiteren Diagnostik oft entscheidend. Der Stellenwert invasiver Methoden, wie z. B. der endoskopischen retrograden Cholangio-Pankreatikographie (ERCP), liegt vornehmlich in der Intervention, insbesondere zur Palliation bei Patienten, deren Erkrankung nicht mehr heilbar ist. (orig.)

  20. Die gebruik van parallelplaatreologie vir die bepaling van die intrinsieke viskositeit van poli-etileentereftalaat

    Directory of Open Access Journals (Sweden)

    O. C. Vorster

    2005-09-01

    Full Text Available Die bepaling van die intrinsieke viskositeit van poli-etileentereftalaat word bemoeilik deur die feit dat daar tans slegs twee metodes in gebruik is. In die eerste metode word die bepaling deur middel van oplossingsviskometrie gedoen, maar die toksisiteit van die oplosmiddel, asook die tydperk wat dit neem om die bepaling te doen, is ’n probleem. Die tweede metode word beperk deur die kompleksiteit en beskikbaarheid van die apparatuur in Suid-Afrika. In hierdie studie word ’n alternatiewe metode, gebaseer op parallelplaatreologie, voorgestel wat albei hierdie probleme oorkom en die resultate sodoende verkry, word vergelyk met dié wat met bestaande metodes verkry is.

  1. IRAN IN DIE INTERNASIONALE MAGSTRYD

    African Journals Online (AJOL)

    neighbours, enjoyed an era of unprecedented economic prosperity and social stability under the administration of the Shah ... influence in the region - a fact borne out by the inconsistent and passive attitude displayed by the Americans throughout ...... belangrikste redes waarom die USSR graag 'n kommunistiese bewind in ...

  2. Die invloed van die neo-marxistiese kultuuranalise op die Wêreldraad van Kerke en die Gereformeerde Kerke van Nederland

    Directory of Open Access Journals (Sweden)

    J. M. Vorster

    1979-05-01

    Full Text Available Toe die studente dwarsoor die VSA en Europa in die laat sestigerjare ’n plotselinge en radikale verset openbaar het teen die bestaande orde, het hulle die deur geopen vir ’n nuwe mededinger om die hart van die Westerse kultuur. Dit is die nou reeds bekende neo-Marxisme. Sedertdien het hierdie jongeling sy voetspore op vele vlakke van die Westerse kultuur gelaat.

  3. Thyroid functional disease: an under-recognized cardiovascular risk factor in kidney disease patients

    Science.gov (United States)

    Rhee, Connie M.; Brent, Gregory A.; Kovesdy, Csaba P.; Soldin, Offie P.; Nguyen, Danh; Budoff, Matthew J.; Brunelli, Steven M.; Kalantar-Zadeh, Kamyar

    2015-01-01

    Thyroid functional disease, and in particular hypothyroidism, is highly prevalent among chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients. In the general population, hypothyroidism is associated with impaired cardiac contractility, endothelial dysfunction, atherosclerosis and possibly higher cardiovascular mortality. It has been hypothesized that hypothyroidism is an under-recognized, modifiable risk factor for the enormous burden of cardiovascular disease and death in CKD and ESRD, but this has been difficult to test due to the challenge of accurate thyroid functional assessment in uremia. Low thyroid hormone levels (i.e. triiodothyronine) have been associated with adverse cardiovascular sequelae in CKD and ESRD patients, but these metrics are confounded by malnutrition, inflammation and comorbid states, and hence may signify nonthyroidal illness (i.e. thyroid functional test derangements associated with underlying ill health in the absence of thyroid pathology). Thyrotropin is considered a sensitive and specific thyroid function measure that may more accurately classify hypothyroidism, but few studies have examined the clinical significance of thyrotropin-defined hypothyroidism in CKD and ESRD. Of even greater uncertainty are the risks and benefits of thyroid hormone replacement, which bear a narrow therapeutic-to-toxic window and are frequently prescribed to CKD and ESRD patients. In this review, we discuss mechanisms by which hypothyroidism adversely affects cardiovascular health; examine the prognostic implications of hypothyroidism, thyroid hormone alterations and exogenous thyroid hormone replacement in CKD and ESRD; and identify areas of uncertainty related to the interplay between hypothyroidism, cardiovascular disease and kidney disease requiring further investigation. PMID:24574542

  4. · Los of vas geskryf: die leksikograaf, die spelreels en die ...

    African Journals Online (AJOL)

    die verskyning van die 1991-uitgawe van die Afriknanse Woordelys en Spelreels het die spelreels en die taalwerklikheid nader aan mekaar ... onder KROM I 1a en b: Die definisie verskyn by die los vorm ... bloot om ortografiese verskille, anders as in gevalle soos geel perske/geel- perske en groot mens/grootmens waar ...

  5. Verskuiwing in die moraal?

    Directory of Open Access Journals (Sweden)

    S.P. van der Walt

    1974-03-01

    Full Text Available Modewoorde het ons deesdae oorgenoeg in die Christelike sedeleer en hulle kan nogal verwarring stig. U moet my vergun om met u te spreek oor een so ’n modewoord nl „verskuiwing’’ in die moraal. Dis nogal ’n mooi woord, wat so dikwels gebruik word op baie terreine en tog meer wil aandui as maar net ’n veranderde sienswyse, ’n wysiging in opvattinge of nuwe riglyne wat al gangbaar geword het in die praktyk. Die begrip wil eintlik die ewolusionêre gang beklemtoon, want dit is dan eintlik net die ou norme wat effens anders bekyk word of nie meer so nou geneem of dik onderstreep word nie. Die verskuiwing beteken dan dat alles nog dieselfde bly, net die posisie of plek het verander. Verskuiwing beteken tog plekverandering of plekwisseling en dan sekerlik nie in die sin dat die plekke ver uitmekaar lê nie. Verskuiwing beteken net maar vlak langs die vorige te staan kom. As dit dan ’n beter plek is, is dit ewolusie, ontwikkeling, verbetering.

  6. Awareness of Dying Preface

    Directory of Open Access Journals (Sweden)

    Barney G. Glaser, PhD, Hon. PhD

    2015-12-01

    Full Text Available Recently The New York Times reported: “VERY ILL CHILDREN TOLD OF DISEASE; Leukemia Patients at N.I.H. Not Shielded From Truth. . . . A child should always be told the truth, even when he has an incurable disease such as leukemia, according to two researchers who interviewed 51 children hospitalized at the National Cancer Institute, Bethesda, Maryland, for treat¬ment of leukemia.” This kind of news item reflects the growing concern among researchers and public about matters which touch on morality as much as on the technical aspects of medi¬cine. The rapidly increasing proportion of elderly people in the American population presents a range of personal and social questions; not the least is how they view their newly won longevity (often including anticipated years of chronic disease as well as their attitudes toward death. In consequence, many geriatric specialists are beginning to study American attitudes toward death, while others, spurred on by what seems a sense-less prolonging of life within hospital walls by medical tech¬nology run wild, are raising questions about death and dying in American life.

  7. Neural correlates underlying micrographia in Parkinson’s disease

    Science.gov (United States)

    Zhang, Jiarong; Hallett, Mark; Feng, Tao; Hou, Yanan; Chan, Piu

    2016-01-01

    Micrographia is a common symptom in Parkinson’s disease, which manifests as either a consistent or progressive reduction in the size of handwriting or both. Neural correlates underlying micrographia remain unclear. We used functional magnetic resonance imaging to investigate micrographia-related neural activity and connectivity modulations. In addition, the effect of attention and dopaminergic administration on micrographia was examined. We found that consistent micrographia was associated with decreased activity and connectivity in the basal ganglia motor circuit; while progressive micrographia was related to the dysfunction of basal ganglia motor circuit together with disconnections between the rostral supplementary motor area, rostral cingulate motor area and cerebellum. Attention significantly improved both consistent and progressive micrographia, accompanied by recruitment of anterior putamen and dorsolateral prefrontal cortex. Levodopa improved consistent micrographia accompanied by increased activity and connectivity in the basal ganglia motor circuit, but had no effect on progressive micrographia. Our findings suggest that consistent micrographia is related to dysfunction of the basal ganglia motor circuit; while dysfunction of the basal ganglia motor circuit and disconnection between the rostral supplementary motor area, rostral cingulate motor area and cerebellum likely contributes to progressive micrographia. Attention improves both types of micrographia by recruiting additional brain networks. Levodopa improves consistent micrographia by restoring the function of the basal ganglia motor circuit, but does not improve progressive micrographia, probably because of failure to repair the disconnected networks. PMID:26525918

  8. Functional abnormalities underlying pathological gambling in Parkinson disease.

    Science.gov (United States)

    Cilia, Roberto; Siri, Chiara; Marotta, Giorgio; Isaias, Ioannis U; De Gaspari, Danilo; Canesi, Margherita; Pezzoli, Gianni; Antonini, Angelo

    2008-12-01

    Pathological gambling (PG) may develop in patients with Parkinson disease (PD) during dopamine replacement therapy, but the underlying neural correlates are still unclear. To investigate resting state brain perfusion in PD patients with active PG compared with matched PD controls and healthy controls. Case-control study. Outpatient tertiary clinic. Eleven right-handed PD patients with active PG according to Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision) criteria, 40 matched PD controls, and 29 age-matched healthy controls. All the participants underwent resting state brain perfusion single-photon emission computed tomography using technetium TC 99m ethylcysteinate dimer bicisate. All PD subjects were taking dopaminergic medication. Statistical Parametric Mapping was used for data analysis (P<.005, false discovery rate corrected). PD patients with PG showed resting state overactivity in a right hemisphere network that included the orbitofrontal cortex, the hippocampus, the amygdala, the insula, and the ventral pallidum. No areas of perfusion reduction were detected. We found that PD patients with PG have abnormal resting state dysfunction of the mesocorticolimbic network possibly associated with a drug-induced overstimulation of relatively preserved reward-related neuronal systems. These findings support the concept that PG is a "behavioral" addictive disorder.

  9. Modern dying: from securing rights to meeting needs.

    Science.gov (United States)

    Solomon, Mildred Z

    2014-11-01

    Modern medicine has transformed the dying experience. In the developed world, most of us no longer die from infectious diseases and sudden accidents, but from chronic illnesses that progressively worsen. Yet the U.S. healthcare system is not designed to meet the needs of people with chronic illness or of frail elders. In addition, our system incentivizes the use of technologies that are often helpful when an underlying condition is reversible but, when used very near the end of life, may only postpone the dying process and increase burdens on the patient. This state of affairs renders many people near the end of life without adequate symptom control, little or no social and psychological support, and inadequate involvement in decisions about when and how best to use modern technologies. This paper traces efforts over the last three decades to address problems related to modern dying. The author sees three phases: early work focused on securing patients' rights to refuse unwanted treatments, the next phase focused on building the specialty of palliative medicine, and the third and future phase must redesign our healthcare system to better align with how we die in the 21st century. © 2014 New York Academy of Sciences.

  10. Forest pathogens and diseases under changing climate-A review

    International Nuclear Information System (INIS)

    Raza, M. M.; Khan, M. A.; Aslam, H. M. U.; Riaz, K.

    2015-01-01

    Changing climate threatens tree health by affecting the likelihood, frequency of occurrence, types and severity of forest diseases caused by diverse pests, resultantly altering the forest ecosystems. The present review covers the relationship between climate and diverse cases of forest diseases and potential shocks of climate change on pathogens and diseases. Biotic diseases, cankers, decays, declines, foliar diseases, root diseases and stem rust of pine have been reviewed with some illustrations of potential disease effects with predicted changing climate. The impact of changing climate on host, pathogen, and their interaction will have frequent and mostly unsympathetic outcomes to forest ecosystems. By employing the proactive and modern scientific management strategies like monitoring, modeling prediction, risk rating, planning, genetic diversity and facilitated migration, genetic protection and breeding for disease resistance and relating results to forest policy, planning as well as decision making, the suspicions innate to climate change effects can be minimized. (author)

  11. New measures to capture end of life concerns in Huntington disease: Meaning and Purpose and Concern with Death and Dying from HDQLIFE (a patient-reported outcomes measurement system).

    Science.gov (United States)

    Carlozzi, N E; Downing, N R; McCormack, M K; Schilling, S G; Perlmutter, J S; Hahn, E A; Lai, J S; Frank, S; Quaid, K A; Paulsen, J S; Cella, D; Goodnight, S M; Miner, J A; Nance, M A

    2016-10-01

    Huntington disease (HD) is an incurable terminal disease. Thus, end of life (EOL) concerns are common in these individuals. A quantitative measure of EOL concerns in HD would enable a better understanding of how these concerns impact health-related quality of life. Therefore, we developed new measures of EOL for use in HD. An EOL item pool of 45 items was field tested in 507 individuals with prodromal or manifest HD. Exploratory and confirmatory factor analyses (EFA and CFA, respectively) were conducted to establish unidimensional item pools. Item response theory (IRT) and differential item functioning analyses were applied to the identified unidimensional item pools to select the final items. EFA and CFA supported two separate unidimensional sets of items: Concern with Death and Dying (16 items), and Meaning and Purpose (14 items). IRT and DIF supported the retention of 12 Concern with Death and Dying items and 4 Meaning and Purpose items. IRT data supported the development of both a computer adaptive test (CAT) and a 6-item, static short form for Concern with Death and Dying. The HDQLIFE Concern with Death and Dying CAT and corresponding 6-item short form, and the 4-item calibrated HDQLIFE Meaning and Purpose scale demonstrate excellent psychometric properties. These new measures have the potential to provide clinically meaningful information about end-of-life preferences and concerns to clinicians and researchers working with individuals with HD. In addition, these measures may also be relevant and useful for other terminal conditions.

  12. Die 'verleentheid' van die teoloog voor die teodiseeprobleem

    African Journals Online (AJOL)

    Moltmann 1976: 138-147 en Jiingel 1978: 55—138) waarmee gewoonlik bedoel word dat God of irrelevant of apaties of magteloos is, word gekenmerk deur 'n verskraalde Godsbegrip. God was nie by Auschwitz nie en is nie in die kankersale van Bloemfontein afwesig nie. Hy is nie magteloos nie en hy is nie liefdeloos nie.

  13. Die Nuwe Testament en mitologie: Die probleem van die ...

    African Journals Online (AJOL)

    29 Mei 2015 ... Die aarde as leefwêreld van mense is oop vir invloede van bo of onder: God en sy engele kan ingryp in .... aanvaar) is om oop te wees vir God se toekoms. Geloof is daarom ook gehoorsaamheid ..... James Dunn stel dit so: 'The dialectic of demythologising is the language of living faith'. (Dunn 1977:301).

  14. Declining Prevalence of Disease Vectors Under Climate Change

    DEFF Research Database (Denmark)

    Escobar, Luis E.; Romero-Alvarez, Daniel; Leon, Renato

    2016-01-01

    More than half of the world population is at risk of vector-borne diseases including dengue fever, chikungunya, zika, yellow fever, leishmaniasis, chagas disease, and malaria, with highest incidences in tropical regions. In Ecuador, vector-borne diseases are present from coastal and Amazonian reg...

  15. Declining Prevalence of Disease Vectors Under Climate Change

    DEFF Research Database (Denmark)

    Escobar, Luis E.; Romero-Alvarez, Daniel; Leon, Renato

    2016-01-01

    More than half of the world population is at risk of vector-borne diseases including dengue fever, chikungunya, zika, yellow fever, leishmaniasis, chagas disease, and malaria, with highest incidences in tropical regions. In Ecuador, vector-borne diseases are present from coastal and Amazonian...

  16. Die monopolievorming in die diamantontginningsnywerheid van Suid-Afrika

    Directory of Open Access Journals (Sweden)

    D. J. Viljoen

    1957-03-01

    Full Text Available Die diamantontginningsnywerheid is een van Suid-Afrika se oudste mynbouvertakkinge. Sedert die eerste diamant in 1867 aan die suidelike oewer van die Oranjerivier in die distrik Hopetown ontdek is, het ’n tydperk van ongeveer 91 jaar verloop, en gedurende hierdie tydperk het die diamantnywerheid baie veranderinge ondergaan.

  17. Die teologiese debat: Die waarde of betekenis daarvan

    African Journals Online (AJOL)

    ander indien hy '... deur die getuienis van die Skrif of deur klaarblyklike rede oortuig kan word, want...ek is gebonde deur die Skrifgetuienis' (Pont 1984:75). Daarmee karakteriseer Luther die kerkhervorming as 'n beweging wat niks anders wil verkondig nie as die Skrifgetuienis oor die verhouding van God, mens en wêreld.

  18. die doel en wese van opvoedende onderwys en die implikasies

    African Journals Online (AJOL)

    Oaar moet onderskei word tussen die doelstellings van opvoedende onderwys en die einddoel wat bereik word deur die nastrewing van hierdie doelstellings. Gunter praat van die naderliggende doelstellings (1981, b1.105). \\/at die enddoel van opvoedende onderwys bet ref, gaan die meeste opvoedkundi ges akkoord dat ...

  19. REDAKSIONEEL DIE ETIEK AGTER MEDE-OUTEURSKAP Die ...

    African Journals Online (AJOL)

    Die publikasie van artikels van twee outeurs waarvan een as die mede-outeur funk- sioneer, is nie in die Hervormde Teologiese Studies 'n vreemde verskynsel nie. Daar word soms na só 'n mede-outeur verwys as die 'honorêre' skrywer van die artikel. Maar is mede-outeurskap eties geregverdig? In 'n uitgawe van die ...

  20. Die kairos van die New Age: 'n Kultuurhistoriese skets

    African Journals Online (AJOL)

    baarheid van alle syn stel Schopenhauer die nie-redelike lewenswii of lewensdrif as diepste verklaring van die werklikheid. Die onversadigbare lewenshonger lei onver- mydelik tot lyding - 'n gedagte wat ten nouste by die Boeddhistiese denke aansluit. Soos die Boeddhiste, leer Schopenhauer dat die mens homself van ...

  1. Neural mechanisms underlying cognitive inflexibility in Parkinson's disease.

    Science.gov (United States)

    Lange, Florian; Seer, Caroline; Loens, Sebastian; Wegner, Florian; Schrader, Christoph; Dressler, Dirk; Dengler, Reinhard; Kopp, Bruno

    2016-12-01

    Cognitive inflexibility is a hallmark of executive dysfunction in Parkinson's disease (PD). This deficit consistently manifests itself in a PD-related increase in the number of perseverative errors committed on the Wisconsin Card Sorting Test (WCST). However, the neural processes underlying perseverative WCST performance in PD are still largely unknown. The present study is the first to investigate the event-related potential (ERP) correlates of cognitive inflexibility on the WCST in PD patients. Thirty-two PD patients and 35 matched control participants completed a computerized version of the WCST while the electroencephalogram (EEG) was recorded. Behavioral results revealed the expected increase in perseverative errors in patients with PD. ERP analysis focused on two established indicators of executive processes: the fronto-central P3a as an index of attentional orienting and the sustained parietal positivity (SPP) as an index of set-shifting processes. In comparison to controls, P3a amplitudes were significantly attenuated in PD patients. Regression analysis further revealed that P3a and SPP amplitudes interactively contributed to the prediction of perseverative errors in PD patients: The number of perseverative errors was only increased when both ERP amplitudes were attenuated. Notably, the two ERP markers of executive processes accounted for more than 40% of the variance in perseverative errors in PD patients. We conclude that cognitive inflexibility in PD occurs when the neural bases of multiple executive processes are affected by the pathophysiology of PD. The combined measurement of P3a and SPP might yield an electrophysiological marker of cognitive inflexibility in PD. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Multiple systemic embolism in infective endocarditis underlying in Barlow's disease.

    Science.gov (United States)

    Yu, Ziqing; Fan, Bing; Wu, Hongyi; Wang, Xiangfei; Li, Chenguang; Xu, Rende; Su, Yangang; Ge, Junbo

    2016-08-11

    Systemic embolism, especially septic embolism, is a severe complication of infective endocarditis (IE). However, concurrent embolism to the brain, coronary arteries, and spleen is very rare. Because of the risk of hemorrhage or visceral rupture, anticoagulants are recommended only if an indication is present, e.g. prosthetic valve. Antiplatelet therapy in IE is controversial, but theoretically, this therapy has the potential to prevent and treat thrombosis and embolism in IE. Unfortunately, clinical trial results have been inconclusive. We describe a previously healthy 50-year-old man who presented with dysarthria secondary to bacterial endocarditis with multiple cerebral, coronary, splenic, and peripheral emboli; antibiotic therapy contributed to the multiple emboli. Emergency splenectomy was performed, with subsequent mitral valve repair. Pathological examination confirmed mucoid degeneration and mitral valve prolapse (Barlow's disease) as the underlying etiology of the endocardial lesion. Continuous antibiotics were prescribed, postoperatively. Transthoracic echocardiography at 1.5, 3, and 6 months after the onset of his illness showed no severe regurgitation, and there was no respiratory distress, fever, or lethargy during follow-up. Although antibiotic use in IE carries a risk of septic embolism, these drugs have bactericidal and antithrombotic benefits. It is important to consider that negative blood culture and symptom resolution do not confirm complete elimination of bacteria. However, vegetation size and Staphylococcus aureus infection accurately predict embolization. It is also important to consider that bacteria can be segregated from the microbicide when embedded in platelets and fibrin. Therefore, antimicrobial therapy with concurrent antiplatelet therapy should be considered carefully.

  3. Ontsporing van die regstaatsbegrip en sy konsekwensies vir die afrikanervolk

    Directory of Open Access Journals (Sweden)

    N. G.S. Van der Walt

    1966-03-01

    Full Text Available Die opvatting van die suiwere regstaat bring sy vraagstukke mee wanneer dit in verband gebring word met die leer van die soewereiniteit in eie kring. Laasgenoemde leer wortel in die geloof dat God die mens roep tot diens aan Hom, en dat die mens vry moet wees om ten opsigte van alle lewensaspekte God na die hoogste mate te kan dien. Hierdie verskeidenheid van aspekte is deur dr. A. Kuyper en sy volgelinge gesistemati- seer tot menslike verbande en lewenskringe, elk met ’n be- paalde sfeer waarin ander kringe nie mag inmeng nie. Elkeen is dan soewerein binne sy eie kring. Met verwysing na die staat is dan gespreek van die staatstaak as synde die hand- hawing van die reg, en omdat die staat in toenemende mate hom veral in die latere tyd ook besig gehou het met bedrywig- hede wat nouliks as van juridiese aard beskou kan word, is daar die onderskeid gemaak tussen die primêre en sekundêre taak van die staat. Die sistematiek van die wetsidee, deur prof. Dooyeweerd ontwikkel, waar die staat sy bestemmingsfunksie in die regsaspek vind, het vanselfsprekend geen plek vir so 'n dualistiese staatstaak nie, en die oplossing is deur sommige daarin gesoek om sulke staatsoptrede te vertolk as hebbende wel betrekking op die regsgemeenskap of die regsverkeer. Staatsondernemings soos paaie, spoorweë, spellingreëling, ens. word dan beskou as noodsaaklik vir die instandhouding van die regsgemeenskap en regsverkeer. Tereg wys A. M. Donner1 daarop dat so ’n vertolking eintlik neerkom op ’n oorspanning van die regsbegrip. Hy self sien dan die staatstaak in vrede- of orde-handhawing, wat in die eerste plaas wel regshandha- wing veronderstel. Onder orde word dan alles verstaan wat noodsaaklik is vir die gladde verkeer in die ontwikkelingsgang van die regsgemeenskap. Die wese van die staat het dan vol- gens hom te doen met reg, maar sy taak is meer as suiwere regshandhawing. Wat onrus verwek en die orde versteur, moet uit die openbare lewe verwyder word, en die

  4. Die sterwende kindjie

    Directory of Open Access Journals (Sweden)

    J.T. De Jongh van Arkel

    1983-09-01

    Full Text Available The thought of a child dying appears as an antithesis and thus the feelings evoked by the dying child are stronger than when older persons are dying. Around the child’s death bed there is no place for detached spectators and all become involved in caring for and supporting him. Caregivers also have a supporting responsibility towards the members of the child’s family.

  5. Recurrent invasive pneumococcal disease in children: underlying clinical conditions, and immunological and microbiological characteristics.

    Directory of Open Access Journals (Sweden)

    Laia Alsina

    Full Text Available Clinical, immunological and microbiological characteristics of recurrent invasive pneumococcal disease (IPD in children were evaluated, differentiating relapse from reinfection, in order to identify specific risk factors for both conditions.All patients <18 years-old with recurrent IPD admitted to a tertiary-care pediatric center from January 2004 to December 2011 were evaluated. An episode of IPD was defined as the presence of clinical findings of infection together with isolation and/or pneumococcal DNA detection by Real-Time PCR in any sterile body fluid. Recurrent IPD was defined as 2 or more episodes in the same individual at least 1 month apart. Among recurrent IPD, we differentiated relapse (same pneumococcal isolate from reinfection.593 patients were diagnosed with IPD and 10 patients died. Among survivors, 23 episodes of recurrent IPD were identified in 10 patients (1.7%. Meningitis was the most frequent form of recurrent IPD (10 episodes/4 children followed by recurrent empyema (8 episodes/4 children. Three patients with recurrent empyema caused by the same pneumococcal clone ST306 were considered relapses and showed high bacterial load in their first episode. In contrast, all other episodes of recurrent IPD were considered reinfections. Overall, the rate of relapse of IPD was 0.5% and the rate of reinfection 1.2%. Five out of 7 patients with reinfection had an underlying risk factor: cerebrospinal fluid leak (n = 3, chemotherapy treatment (n = 1 and a homozygous mutation in MyD88 gene (n = 1. No predisposing risk factors were found in the remainder.recurrent IPD in children is a rare condition associated with an identifiable risk factor in case of reinfection in almost 80% of cases. In contrast, recurrent IPD with pleuropneumonia is usually a relapse of infection.

  6. Analise van die Tswanaraaisel

    Directory of Open Access Journals (Sweden)

    S. A. Swanepoel

    1984-05-01

    Full Text Available ’n Strukturele, stilistiese en funksionele bcskrywing van die Twanaraaisel bring mee dat daar aan die volgende aspekte aandag gegee moet word: •\tWat is ’n raaisel en lioe word dit in Tswana genoem. •\tTot watter studiegebied en literere genre hoort die raaisel en watter subvorme kan vir Tswana onderskei word. •\tHoe sien die struktuur van Tswanaraaisels daar uit. •\tDeur wie, waar, wanneer en hoe word Tswanaraaisels voorgedra. •\tWatter stilistiese kenmcrke kan in Tswanaraaisels onderskei word. •\tWatter funksies vervul raaisels in ’n Tswanagcmeenskap.

  7. Die brein soos beskou deur die Grieke en Romeine

    Directory of Open Access Journals (Sweden)

    Francois P. Retief

    2015-02-01

    Full Text Available In Ou Egipte is mummifikasie met uitgebreide reseksie of uitsnyding van organe geassosieer, maar geen kennis is geneem van die morfologie van die brein nie. Griekse skrywers van die sesde en vyfde eeue v.C. het die brein aanvanklik gesien as die setel van intelligensie, die orgaan van sensoriese waarneming en gedeeltelik die oorsprong van sperma. Pneuma het ’n belangrike rol in breinfunksie gespeel. Hippokrates was die eerste om die brein te beskryf as ’n dubbele orgaan, wat met harsingvlies (meninges bedek, funksioneel van pneuma afhanklik en vertolker van begrip is. Tydgenote soos Plato, Aristoteles en Diokles het tot die beskrywing bygedra, maar laasgenoemde twee het beweer dat die hart die middelpunt van intelligensie is en nie die brein nie. Gedurende die laaste helfte van die vierde eeu v.C. is disseksie van die menslike liggaam tydelik aan die mediese skool van Alexandrië toegelaat en het dit tot merkwaardige vooruitgang in die begrip van die menslike anatomie en fisiologie gelei. Herofilus en Erasistratus het uitstekende beskrywings van die struktuur en funksie van die brein gegee wat eers in die tweede eeu n.C. deur Galenus geëwenaar is.

  8. DIE SUID-AFRIKAANSE JEUG IN VOORTREKKERTYDPERK

    African Journals Online (AJOL)

    dien. Die planke en velie moes keer dat die assegaaie die mense tref. Voor die geveg het die vrouens en groter dogters koeels gegiet. Tydens die geveg het die seuns gehelp skiet terwyl die vrouens en dogters die gewere vir die mans gelaai het. Van die dogters soos Nellie. Botha (11 jaar oud) en haar sussie Fya (15 jaar.

  9. Mechanisms underlying disease transmission between spatially separated animals

    NARCIS (Netherlands)

    Bunnik, van B.A.D.

    2014-01-01

    Transmission of infections between spatially separated hosts is a common problem, not only during major outbreaks of livestock diseases, but also in many other settings such as the transmission of infectious diseases between plants and crops or in healthcare settings. During the last

  10. Cognitive Development in Infantile-Onset Pompe Disease Under Very Early Enzyme Replacement Therapy.

    Science.gov (United States)

    Lai, Chih-Jou; Hsu, Ting-Rong; Yang, Chia-Feng; Chen, Shyi-Jou; Chuang, Ya-Chin; Niu, Dau-Ming

    2016-12-01

    Most patients with infantile-onset Pompe disease die in early infancy before beginning enzyme replacement therapy, which has made it difficult to evaluate the impact of Pompe disease on cognitive development. Patients with infantile-onset Pompe disease can survive with enzyme replacement therapy, and physicians can evaluate cognitive development in these patients. We established an effective newborn screening program with quick clinical diagnostic criteria. Cognitive and motor development were evaluated using the Bayley Scales of Infant and Toddler Development-Third Edition at 6, 12, and 24 months of age. The patients who were treated very early demonstrate normal cognitive development with no significant change in cognition during this period (P = .18 > .05). The cognitive development was positively correlated with motor development (r = 0.533, P = .011). The results indicated that very early enzyme replacement therapy could protect cognitive development in patients with infantile-onset Pompe disease up to 24 months of age. © The Author(s) 2016.

  11. Die oorbrug van ’n generasiegaping: Die volwasse jeugboekskrywer in gesprek met die jong leser

    Directory of Open Access Journals (Sweden)

    H. du Plessis

    2000-04-01

    Full Text Available Die skrywer van die jeugboek is in verreweg die meeste gevalle ’n volwassene, terwyl die verteller soms grootmens, soms jongmens is, en die veronderstelde leser per definisie altyd ’n jeugdige. In wese dus ’n paradoks, ’n teelaarde vir ’n kommunikasiegaping. Hoe oorleef die skrywer dié paradoks?

  12. N HERSIENING VAN DIE AFRIKAANSE VERTALING VAN DIE ...

    African Journals Online (AJOL)

    Test

    aksie aan die kant van die man, wat beter weer te gee is met „ver stoting"^). Maar apoÍM^in met die ... 'n nuwe afrikaanse woord, wat minstens trou is aan die oorspronklike en wat nie die misverstand voortsit nie, te vind. .... Mt. 28 : 1: Opse de sabbatön te epipha^onse, eis mian sabhatön . . . gee die Afr. Vert. die geleentheid ...

  13. Die impak van kritiek op die samestelling van die Woordeboek van die Afrikaanse Taal (WAT

    Directory of Open Access Journals (Sweden)

    Willem Botha

    2011-10-01

    Full Text Available

    Opsomming: Die WAT se sensitiwiteit vir kritiek blyk duidelik uit die feit dat geeneen vandie hoofpunte van kritiek ten opsigte van die eerste ag dele in die kritiek op dele IX en X herhaalword nie. Ensiklopediese behandeling van leksikale items, die ingewikkeldheid of onverstaanbaarheidvan betekenisverklarings, die ondeurdagte aanwending van voorbeeldmateriaal, stadige alfabetiesevordering en die afwesigheid van volledige uitspraakleiding figureer derhalwe nie in diekritiek op dele IX en X nie. Die artikel gee 'n oorsig van die hoofpunte van kritek op dele IX en X enbespreek hoe die WAT in daaropvolgende dele op die kritiek gereageer het. In gevalle waar daarnie op geldige kritiek ag geslaan is nie, of waar die kritiek nie met praktiese voorstelle gepaardgegaanhet nie, word aanpassings aan die hand gedoen. Sodoende word die wisselwerking tussenleksikografiese teorie en praktyk 'n dinamiese proses.

    Sleutelwoorde: HOOFPUNTE VAN KRITIEK, OMGANGSTAAL, VOLGORDE VANSITATE, UITSPRAAKLEIDING, ONBEREIKBARE VERWYSINGS, MISLEIDENDE SINONIEMVERWYSINGS,WISSELWERKING TUSSEN LEKSIKOGRAFIESE TEORIE EN PRAKTYK

    Abstract: The Impact of Criticism on the Compilation of the Woordeboekvan die Afrikaanse Taal (WAT. The WAT's sensitivity to criticism is evident from the factthat none of the main points of criticism against the first eight volumes is repeated in the criticismof volumes IX and X. Encyclopedic treatment of lexical items, complexity or incomprehensibility ofmeaning descriptions, ill-judged use of citations, slow alphabetic progress and the absence of fullpronunciation guidance therefore do not feature in the criticism on volumes IX and X. The articlegives an overview of the main points of criticism against the ninth and tenth volumes and discussesthe way in which the WAT reacted to the criticism in subsequent volumes. In instanceswhere valid critique was disregarded, or where the critique was not accompanied by practicalsolutions

  14. Oor die Bybel in die Afrikaanse digkuns

    African Journals Online (AJOL)

    another. As a matter of fact, the development of Afri kaans, the instrument of the poet, has been significantly influenced the Afrikaans translation of the Bible. Belie ... ook gesê het: Saam met ons literatuur, so oud as hy is. Die eerste Afrikaanse digter by wie ons omvattende Bybelse invloed kry, is. Totius, een van ons vroegste ...

  15. Relation of ventricular premature beats to underlying heart disease.

    Science.gov (United States)

    Uretz, E F; Denes, P; Ruggie, N; Vasilomanolakis, E; Messer, J V

    1984-03-01

    The relation between ventricular premature beats (VPBs) and physiologic disease was investigated in 305 patients who had 24-hour Holter monitoring tests, cardiac catheterization and angiography. Both frequency and Lown class of VPBs were measured. Analyses showed that occurrence of VPBs at an average frequency of more than 2 per hour or occurrence of complex VPBs (Lown class greater than 2) have the highest association with the presence and severity of cardiac disease. Using these criteria, VPB severity was then compared with extent of ventricular wall motion abnormality (right anterior oblique projection segments), ejection fraction, end-diastolic pressure, category of disease (normal, coronary artery disease [CAD], valvular heart disease, dilated cardiomyopathy), age and severity of CAD (major coronary arteries with greater than 75% diameter reduction). Severe VPBs defined either by complexity or frequency were significantly correlated with extent of wall motion abnormality, ejection fraction, category of disease and age. Severe VPBs were not significantly correlated with end-diastolic pressure or severity of CAD. Discriminant analysis then showed that in addition to wall motion abnormality and ejection fraction, category of disease and age are independently correlated with VPB severity.

  16. [Advances on pharmacokinetics of traditional Chinese medicine under disease states].

    Science.gov (United States)

    Gong, Zi-peng; Chen, Ying; Zhang, Rui-jie; Yang, Qing; Zhu, Xiao-xin

    2015-01-01

    In recent years, more and more research shows that the pharmacokinetic parameter of traditional Chinese medicine can be affected by the disease states. It's possible that drug metabolic enzymes, transporters, cell membrane permeability and the change of microbes group could be interfered with physiological and pathological changes, which enables the pharmacokinetics of traditional Chinese medicine in the body to be altered, including the process of absorption, distribution, metabolism and excretion, and then the pharmacokinetic parameters of traditional chinese medicine are altered. It's found that investigating the pharmacokinetic of traditional Chinese medicine in the pathological state is more useful than that of in normal state because the great part of traditional Chinese medicine is mainly used to treat disease. This article reflects the latest research on the pharmacokinetic of traditional Chinese medicine in the disease state such as diabete, cerebral ischemia, liver injury, inflammatory disease, nervous system disorders and fever in order to provide certain reference for clinicians designing reasonable administration dose.

  17. calvyn oor die leiding van die heilige gees in die verklaring van die

    African Journals Online (AJOL)

    Mittel alters, bis er zur Ruhe kommt bei den kanonischen Schriften der. Urzeit der christlichen Ära (Barth ... (ego tamen dimoveri non possum ab amore compendii, CO 10, 403). Deur die boodskap van die .... Idem ergo spiritus qui per os prophetarum loquutus est, in corda nostra penetret necesse est, ut persuadeat fideliter ...

  18. Die skeppingsordeninge en homoseksualiteit

    African Journals Online (AJOL)

    BERKOUWER, GC 1974. Een halve eeuw theologie. Kampen: Kok. BRUNNER, E 1934. Unsere Glauhe. Ziirich: Zwingli. BRUNNER, E 1939. Das Gebot und die Ordnungen. Ziirich: Swingli. BRUNNER, E 1950. Die Christliche Lehre von Schopfung und Erlosung. Ziirich; Zwingli. GEREFORMEERDE KERKEN NEDERLAND.

  19. Die Bilder zum Text

    OpenAIRE

    Loesch, Perk

    2007-01-01

    Die ebenso glückliche, wie schöne und wertvolle Erwerbung einer Handschrift von Wilhelm Dilich (1571/72-1650) für die Handschriftensammlung der SLUB gibt Veranlassung, nicht allein diese Handschrift vorzustellen, sondern auch an ihren Verfasser zu erinnern, dessen Wirken gleichermaßen mit Hessen und Sachsen verbunden ist.

  20. Die entwicklung, die metamorphose, die entstehung: Die konzepte des organismus von Aristoteles bis Darwin

    Directory of Open Access Journals (Sweden)

    Kamerer Eva

    2009-01-01

    Full Text Available (nemački In diesem Aufsatz versuche ich, die Elemente verschiedener Konzepte des Organismus in der Philosophie und in der Wissenschaft zu analysieren. Die Deutungen des Organismus und der Einheit der Natur bei Aristoteles, Kant und Goethe werden als ein Beispiel der Bewegung von einem finalistischen zum antifinalistischen Bild der Natur verstanden.

  1. Therapeutical approaches under investigation for treatment of Chagas disease.

    Science.gov (United States)

    Bahia, Maria Terezinha; Diniz, Lívia de Figueiredo; Mosqueira, Vanessa Carla Furtado

    2014-09-01

    A century after its discovery, American trypanosomiasis or Chagas disease remains a serious health problem in Latin America, where it affects around 7 - 8 million people. The prevalence of Chagas disease in the poorer parts of the world has meant that it has largely been neglected with limited progress that made in identifying new drugs for the treatment. The nitroheterocyclic drugs nifurtimox and benznidazole are first-line drugs available for Chagas disease with limitations that include variable efficacy, long treatment courses and toxicity. This review focuses on different therapeutic strategies that have been used for the discovery of new treatments for Chagas disease. These include combination chemotherapy, drug repositioning, re-dosing regimens for current drugs and the identification of new drugs with specified target profiles. There are currently several reasons for a more optimistic view about chemotherapy with Chagas disease. However, despite some progress being made in preclinical studies, there is yet to be an ideal drug or formulation for human treatment. One major drawback in the evaluation of potential Chagas disease therapeutics is the lack of tools available to perform the said evaluation. Indeed, there is a great need to discover a better biomarker that could determine the efficacy of potential chemotherapeutics in treated patients.

  2. Sendinginvloed op die Sepediversvorm – Die kerklied | Groenewald ...

    African Journals Online (AJOL)

    Die woordgroepvers is as 'a borderline case between Verse and Prose' beskryf. Ook het die sendelinge nie hiermee rekening gehou dat rym in Sepedi nie ʼn doeltreffende middel is om versmaat te definieer nie. Hulle het die liedere gevolglik as heffingsverse saamgestel. Die ekwivalensie van die versreëls word daarom ...

  3. die ontstaan en ontwikkeling van die kwartiermeester-generaal

    African Journals Online (AJOL)

    1 Okt 1976 ... Verskillende korpse is ingestel en verskeie funk- sies, waaronder ook die logistieke funksie is uit- gevoer.1. Die eerste Verdedigingsregulasies word op 23. Desember 1912 gepubliseer. Volgens hierdie regulasies is die departement van Verdediging in drie afdelings verdeel, nl die Afdeling van die.

  4. die aard, studieveld en funksie van die krygsgeskiedenis1

    African Journals Online (AJOL)

    word, juis omdat hy hom met grondbeginsels, soos die Invloed van politlek en die menslike natuur op militere operasles, besig gehou het.33. Die beroemde militere denker, Carl von Clausewitz, het egter tereg daarop gewys dat die mees resente krygsgeskiedeins vanself- sprekend die beste bron vir historlese voorbeelde.

  5. sinkronisasie van estrus by die sa vleismerino: die invloed op ...

    African Journals Online (AJOL)

    ). Deur clie dosis DMSG van 300 tot tr00 lE te verhoog, het die aantal lammers per ooie gepaar met l4,l persent gedaal (P < 0,05). Die persentasie meerlinge van die or-rie *at beset geraak het, was die hoogste in die 600 tE DN{SG groep ...

  6. Die Suid-Afrikaanse Oorlogsekonomie gedurende die Tweede ...

    African Journals Online (AJOL)

    invoerbeheer is dit benewens die invoer- permit vereis. ii. In die geval van invoere uit die Gemene- beslande, was geen permitte nie maar wei noodsaaklikheidsertifikate nodig. d. Uitvoerpermitte i. Geen permitte is in die geval van goedere wat na die Verenigde Koninkryk, Noord- lerland, Kanada, Australie, Nieu-Seeland,.

  7. amp' van die ouderling in die Nuwe Testament

    African Journals Online (AJOL)

    Jesus self het geen kerk gestig nie en daarom, veral omdat die Jesus-beweging inter mums ten opsigte van die Joodse godsdiens van sy tyd tot stand gekom het, het ...... Die klem val dus nie op die npoTCTT0fievo<; se rang of outoriteit nie, maar op sy pastorale funksie in die huishouding of huisgemeente (kyk Reicke.

  8. DIE BETREKKING TUSSEN JESUS EN JOHANNES DIE DOPER Na ...

    African Journals Online (AJOL)

    Test

    eeue veral 'n ernstige bedreiging vir die Christelike gemeente, altans in sekere gebiede, geword het/) Die methode van weerlegging van die Doper-aansprake, wat in die Pseudo-clementyne gevolg word, is die sogenaamde suzH#:a: (Hom. 2. 16-17 en Rec. 3. 16). Hierdie skolastiese bewys-methode voer aan dat God alles ...

  9. High-utilizing Crohn's disease patients under psychosomatic therapy*

    Science.gov (United States)

    Deter, Hans-Christian; von Wietersheim, Jörn; Jantschek, Günther; Burgdorf, Friederike; Blum, Brigitta; Keller, Wolfram

    2008-01-01

    Objective Few studies have been published on health care utilization in Crohn's disease and the influence of psychological treatment on high utilizers. Methods The present sub study of a prospective multi center investigation conducted in 87 of 488 consecutive Crohn's disease (CD) patients was designed to investigate the influence of the course of Crohn's disease on health care utilization (hospital days (HD) and sick leave days (SLD) collected by German insurance companies) and to examine the conditions of high-utilizing patients. Predictors of health care utilization should be selected. Based on a standardized somatic treatment, high health care utilizing patients of the psychotherapy and control groups should be compared before and after a one-year treatment. Results Multivariate regression analysis identified disease activity at randomization as an important predictor of the clinical course (r2 = 0.28, p < 0.01). Health care utilization correlated with duration of disease (p < 0.04), but the model was not significant (r2 = 0.15, p = 0.09). The patients' level of anxiety, depression and lack of control at randomization predicted their health-related quality of life at the end of the study (r2 = 0.51, p < 0.00001). Interestingly, steroid intake and depression (t1) predicted the combined outcome measure (clinical course, HRQL, health care utilization) of Crohn's disease at the end of the study (r2 = 0.22, p < 0.001). Among high utilizers, a significantly greater drop in HD (p < 0.03) and in mean in SLD were found in the treatment compared to the control group. Conclusion The course of Crohn's disease is influenced by psychological as well as somatic factors; especially depression seems important here. A significant drop of health care utilization demonstrates the benefit of psychological treatment in the subgroup of high-utilizing CD patients. Further studies are needed to replicate the findings of the clinical outcome in this CD subgroup. PMID:18851749

  10. Epigenetic mechanisms underlying the pathogenesis of neurogenetic diseases.

    Science.gov (United States)

    Qureshi, Irfan A; Mehler, Mark F

    2014-10-01

    There have been considerable advances in uncovering the complex genetic mechanisms that underlie nervous system disease pathogenesis, particularly with the advent of exome and whole genome sequencing techniques. The emerging field of epigenetics is also providing further insights into these mechanisms. Here, we discuss our understanding of the interplay that exists between genetic and epigenetic mechanisms in these disorders, highlighting the nascent field of epigenetic epidemiology-which focuses on analyzing relationships between the epigenome and environmental exposures, development and aging, other health-related phenotypes, and disease states-and next-generation research tools (i.e., those leveraging synthetic and chemical biology and optogenetics) for examining precisely how epigenetic modifications at specific genomic sites affect disease processes.

  11. Die Reformdiskussion in der senegalesischen Sprachplanungs- politik

    African Journals Online (AJOL)

    Die neue Schule hat sowohl die Eigenschaften der Kanone wie des Magnets: Mit der Kanone teilte sie die Wirksamkeit einer Kampfwaffe. Besser als die Kanone es kann, verleiht die Schule der Eroberung auf Dauer. Die Kanone bezwingt nur den Leib, die Schule erobert die Seelen. […] Mit dem Magnet hat die Schule die.

  12. Demonologie in die Nuwe- Testamentiese tydvak

    African Journals Online (AJOL)

    Bose altyd as die wederstrewige mag in die mens wat stry teen die oormag van die Woord van God. Die verwesenliking van hierdie tweërlei doelwit vra na riglyne om die demonologie as verskynsel in die Nuwe-Testamentiese tydvak te interpreteer. Die inhoud van my bydrae gaan hoofsaaklik in op die oorsprong van die ...

  13. Getting Under the Skin: The Inscription of Dermatological Disease ...

    African Journals Online (AJOL)

    8; Papadopoulos, Bor & Legg, 1999, p. 107). Chronic cutaneous disease is often visible to others so that social factors in coping and adjustment are thus highly relevant (Papadopoulos, et al., 1999, p. 107). Psychological factors tend, however, to be overlooked in the dermatological treatment domain when the skin problem ...

  14. Yellow Vein Mosaic disease in kenaf ( Hibiscus cannabinus l.) under ...

    African Journals Online (AJOL)

    Nucleic acid spot hybridization (NASH) was used to confirm the disease and the results revealed that Begomovirus was present in kenaf sowm in the two locations during the period of the three months except in kenaf sown in July at Ilora. The results of this study revealed the importance of sowing dates on the occurrence of ...

  15. Underlying congenital heart disease in Nigerian children with ...

    African Journals Online (AJOL)

    EB

    2013-09-03

    Sep 3, 2013 ... Abstract. Background: Pneumonia is a common cause of childhood morbidity and mortality globally. Some congenital heart disease. (CHD) may predispose their sufferer to bronchopneumonia. Objective: To evaluate the contribution of CHD to pneumonia in children seen in a tertiary hospital. Methods: Over ...

  16. Underlying congenital heart disease in Nigerian children with ...

    African Journals Online (AJOL)

    Background: Pneumonia is a common cause of childhood morbidity and mortality globally. Some congenital heart disease(CHD) may predispose their sufferer to bronchopneumonia. Objective: To evaluate the contribution of CHD to pneumonia in children seen in a tertiary hospital. Methods: Over a year, consecutive ...

  17. Pentateugtradisies in die boek Hosea

    African Journals Online (AJOL)

    om te bepaal of die verwysing na 'n gebeure te doen het met die verre verlede of met die .... Hosea 2:1-2 JHWH se trou aan sy beloftes. ... dat huile na Egipte sal terugkeer. Die presiese bedoeiing van die woorde 'huile sal terugkeer na Egipte' is omstre- de. Kommentatore soos Rudolph meen dat dit verstaan moet word as ...

  18. Die begrafnisdíens

    African Journals Online (AJOL)

    (De Vaux 1961:108). Was die begrafnis 'n familie of 'n kerklike aangeleentheid? Hierdie vraag word nie in die Bybel beantwoord nie. Abraham het sy vrou begrawe (Gen 23: 19-. 20). Isak en Ismael ..... ver gekom om die begrafnis 'n kerklike aangeleentheid te maak nie. Hierdie stap .... trou aan die sorg van God. * Die kerk ...

  19. Metodes in die Christelike etiek

    African Journals Online (AJOL)

    The basic question in Christian ethics is not primarily. 'What should I do?' The basic question is rather ' ... should therefore be accepted as being part of the method used in Christian ethics. 1. INLEIDEND ..... aan die kant van die onderdrukte' verkondig word, word die Christen opgeroep om horn te skaar aan die kant van die ...

  20. Die owerheidsinmenging met betrekking tot kerklike tughandelinge.

    Directory of Open Access Journals (Sweden)

    L. Roeleveld

    1982-06-01

    Full Text Available Volgens art 29 NGB is die merktekens van die ware kerk die suiwere prediking van die Evangelie, die suiwere bediening van die Sakramente en die gebruik van die kerklike tug. Art. 32 NGB spreek uit dat die Kerkorde nie mag afwyk van wat Christus ingestel het nie. Menslike vindinge en wette om die gewetens te bind en te dwing, moet daarom verwerp word. Die ekskommunikasie of die ban moet toegepas word volgens die Woord van God.

  1. High-utilizing Crohn's disease patients under psychosomatic therapy*

    Directory of Open Access Journals (Sweden)

    Jantschek Günther

    2008-10-01

    Full Text Available Abstract Objective Few studies have been published on health care utilization in Crohn's disease and the influence of psychological treatment on high utilizers. Methods The present sub study of a prospective multi center investigation conducted in 87 of 488 consecutive Crohn's disease (CD patients was designed to investigate the influence of the course of Crohn's disease on health care utilization (hospital days (HD and sick leave days (SLD collected by German insurance companies and to examine the conditions of high-utilizing patients. Predictors of health care utilization should be selected. Based on a standardized somatic treatment, high health care utilizing patients of the psychotherapy and control groups should be compared before and after a one-year treatment. Results Multivariate regression analysis identified disease activity at randomization as an important predictor of the clinical course (r2 = 0.28, p 2 = 0.15, p = 0.09. The patients' level of anxiety, depression and lack of control at randomization predicted their health-related quality of life at the end of the study (r2 = 0.51, p 2 = 0.22, p Among high utilizers, a significantly greater drop in HD (p Conclusion The course of Crohn's disease is influenced by psychological as well as somatic factors; especially depression seems important here. A significant drop of health care utilization demonstrates the benefit of psychological treatment in the subgroup of high-utilizing CD patients. Further studies are needed to replicate the findings of the clinical outcome in this CD subgroup.

  2. Effects of long-term exposure to raod traffic imissions on the pathogenesis of diseases of the skin and respiratory tract in children; Auswirkungen langfristiger Expositionen gegenueber Strassenverkehrsimissionen auf die Entwicklung von Haut- und Atemwegserkrankungen bei Kindern

    Energy Technology Data Exchange (ETDEWEB)

    Ising, H. [Umweltbundesamt, Berlin (Germany); Lange-Asschenfeldt, H. [Bundesministerium fuer Gesundheit, Berlin (Germany); Lieber, G.F.; Weinhold, H.; Eilts, M.

    2002-10-01

    The pathogenesis of allergies can be stimulated by adjuvant effects, i.e. air pollutants such as NO{sub x} and particles from diesel engines and also noise - the latter especially during the night. During sleep, noise signals that are associated with danger (e.g. noise from lorries) can potentially trigger stress reactions even if the noise level is low. Higher cortisol levels in the first half of the night seem to have an important role in this. In a blind interview study, the combined effects of chronic exposure to traffic-related air pollution and noise upon the risk of allergic skin and respiratory diseases in children were studied. All children between 5 and 12 years of age who had consulted one of two of the participating pediatricians were included in the study. The paediatricians' diagnoses for 400 children were analysed together with their parents' answers to questions on the density of road traffic in the streets where they live and several confounding factors. Multiple regression analyses revealed relative risks of asthma, chronic bronchitis and neurodermitis that rose significantly with increasingly heavy traffic. A comparison with corresponding results reported in the literature for air pollution alone showed that traffic noise during the night might have an enhancing (adjuvant) effect in the pathogenesis of these diseases. (orig.) [German] Die Entstehung von Allergien kann durch adjuvante Effekte - z.B. Immissionen aus dem Verkehrsbereich - gefoerdert werden. Zu solchen Immissionen zaehlen gas- und partikelfoermige Schadstoffe wie Stickoxide und Dieselruss sowie Laerm, insbesondere in der Nacht. Waehrend des Schlafs koennen Geraeusche, die mit Gefahren assoziiert sind (z.B. Lkw-Geraeusche) auch bei niedrigen Pegeln Stressreaktionen ausloesen. Kortisolerhoehungen in der ersten Haelfte der Nacht scheinen dabei eine wichtige Rolle zu spielen. In einer 'einfach-blind' durchgefuehrten Befragungsstudie wurden langzeitige Auswirkungen

  3. 'n Model vir die meting van die bou- rekenaar se ...

    African Journals Online (AJOL)

    . 'n Vraelys is in 2010 aan geselekteerde praktiserende bourekenaars, argitekte, ingenieurs, kliënte en aannemers per e-pos gesirkuleer met die doel om sienings ten opsigte van die volwassenheid van bourekenkundige kommunikasie in die ...

  4. die waarde van die ou testament volgens hf kohlbrugge

    African Journals Online (AJOL)

    En: “As jy die vyf boeke van Moses verstaan, verstaan jy die hele Skrif.” 3.3 Die slot van die boek. Kohlbrugge (1855:133) het nie verwag dat hy die aan nuwerwetse geleerdes voldoening sou verskaf met hierdie boek nie. Wel voel hy dat hy sy doel be- reik het. Daardie doel was om elke denkende gemoed te oortuig dat die ...

  5. Ethnographic study of diarrhoeal diseases among under-five ...

    African Journals Online (AJOL)

    A cross-sectional design was employed to identify the local cosmology of childhood diarrhoea and its local treatment procedures. A total of 848 under-five children were identified by a quick inventory of randomly selected kebeles. Trained enumerators administered a pre-tested questionnaire in order to identify the ...

  6. Die Zeitung der Zukunft

    Science.gov (United States)

    Wieser, Christoph; Schaffert, Sebastian

    Schon lange wird spekuliert, wie wir in Zukunft Zeitung lesen werden. Werden wir am Frühstückstisch wie gewohnt in einer Zeitung aus Papier schmökern oder werden wir die Zeitung als biegsame Folie beschrieben mit elektronischer Tinte in Händen halten? Wird die Zeitung mit anderen Medien wie Radio und Fernsehen verschmelzen? Viele Varianten sind denkbar. Heute lässt sich schon ein Trend ablesen: Immer mehr Leser entdecken die Online-Zeitung als Informationsmedium, eine Voraussetzung für die Nutzung neuer Technologien in der Zeitung der Zukunft. In diesem Kapitel stellen wir Entwicklungsmöglichkeiten der Online-Zeitung dar, wie sie im Social Semantic Web möglich werden.

  7. Die Wahrheit des Holocaust

    Directory of Open Access Journals (Sweden)

    Michael Stolleis

    2003-01-01

    Full Text Available Rezensiertes Werk: Raul Hilberg, Die Quellen des Holocaust. Entschlüsseln und Interpretieren. Deutsch von Udo Rennert, Frankfurt am Main: S. Fischer 2002, 256 S., ISBN 3-10-033626-7

  8. Die Bibliothek des Bezirksmuseums Josefstadt

    Directory of Open Access Journals (Sweden)

    Maria Ettl

    2015-01-01

    Josefstadt in Wien werden die Herkunft der Bibliotheksbestände und die beengte Raumsituation beschrieben. Abschließend wird auf die Erfassung der Medien mittels der Bibliothekssoftware „Biblioweb“ eingegangen.

  9. Die verband tussen die sielkundige kontrak en organisasieverbondenheid

    Directory of Open Access Journals (Sweden)

    K. J. Stanz

    1999-06-01

    Full Text Available The relationship between the psychological contract and organisational commitment. The aim of this study is to design a measuring instrument with acceptable metric characteristics for the strength of the psychological contract within the South African context, and to determine empirically the relation between the strength of the psychological contract and organisational commitment. The Dhammanungune Model served as foundation for the design of the Strength of the Psychological Contract Questionnaire which consists of two scales namely, a needs expectation scale and a needs fulfilment expectation scale. The items of each scale have been formulated in the manner that ensures that the respondent reacts consecutively to two instructions namely, (a the level of the expectation and (b the importance of the expectation. This questionnaire was administered together with the Organisational Commitment Questionnaire to two population groups within the military environment. The Pearson Product Moment Correlation was calculated between the strength of the psychological contract and organisational commitment and the significance of the correlations was evaluated. Opsomming Die doel van die studie is om 'n meetinstrument met aanvaarbare metriese eienskappe vir die sterkte van die sielkundige kontrak vir Suid-Afrikaanse omstandighede te ontwerp en om empirics die verband tussen die sterkte van die sielkundige kontrak en organisasieverbondenheid te bepaal. Die sterkte van die sielkundige kontrak vraelys is op grond van die Dhammanungune-model ontwerp en het uit twee skale naamlik, die behoefteverwagting- en vervullingsverwagtingskale bestaan. Items vir eike skaal is sodanig geformuleer dat die respondent agteropeenvolgens op twee instruksies naamlik (a die vlak van die verwagting en (b die belangrikheid van die verwagting moet reageer. Die vraelys is saam met die organisasieverbondenheidsvraelys op twee populasies uit 'n militere omgewing toegepas. Die Pearson

  10. van die WATt

    African Journals Online (AJOL)

    Verder word 'n rekenaarveldstruktuur voorgestel waarvolgens inligting op skerm in die woordeboek in-. Dit is 'n bygewerkte weergawe van 'n referaat wat op 4 Julie 1990 by 'n kongres van die LVSA op. Stellenbosch gelewer is. R ep rod u ced b y Sa b in et G a tew a. y u n d er licen ce gra n ted b y th e P u b lish er (d a ted.

  11. The day Madiba died

    African Journals Online (AJOL)

    8 Apr 2016 ... geweld (“Utopia” [129–41]—Christina van Deventer), die seksuele misbruik van kinders (“Een, twee, drie, blok myself”. [98–103]—Ilisna Nel), posttraumatiese stres (“Ontspoor” [117–22]—Tanya van. Buuren) en geestestoornisse (“Lettie se verlies” [150–5]—Elani Venter) word ondersoek. In die satiriese ...

  12. NOX Activation by Subunit Interaction and Underlying Mechanisms in Disease.

    Science.gov (United States)

    Rastogi, Radhika; Geng, Xiaokun; Li, Fengwu; Ding, Yuchuan

    2016-01-01

    Nicotinamide adenine dinucleotide phosphate (NAPDH) oxidase (NOX) is an enzyme complex with the sole function of producing superoxide anion and reactive oxygen species (ROS) at the expense of NADPH. Vital to the immune system as well as cellular signaling, NOX is also involved in the pathologies of a wide variety of disease states. Particularly, it is an integral player in many neurological diseases, including stroke, TBI, and neurodegenerative diseases. Pathologically, NOX produces an excessive amount of ROS that exceed the body's antioxidant ability to neutralize them, leading to oxidative stress and aberrant signaling. This prevalence makes it an attractive therapeutic target and as such, NOX inhibitors have been studied and developed to counter NOX's deleterious effects. However, recent studies of NOX have created a better understanding of the NOX complex. Comprised of independent cytosolic subunits, p47- phox , p67- phox , p40- phox and Rac , and membrane subunits, gp91- phox and p22- phox , the NOX complex requires a unique activation process through subunit interaction. Of these subunits, p47- phox plays the most important role in activation, binding and translocating the cytosolic subunits to the membrane and anchoring to p22- phox to organize the complex for NOX activation and function. Moreover, these interactions, particularly that between p47- phox and p22- phox , are dependent on phosphorylation initiated by upstream processes involving protein kinase C (PKC). This review will look at these interactions between subunits and with PKC. It will focus on the interaction involving p47- phox with p22- phox , key in bringing the cytosolic subunits to the membrane. Furthermore, the implication of these interactions as a target for NOX inhibitors such as apocynin will be discussed as a potential avenue for further investigation, in order to develop more specific NOX inhibitors based on the inhibition of NOX assembly and activation.

  13. Die postpolitische Stadt

    Directory of Open Access Journals (Sweden)

    Erik Swyngedouw

    2013-12-01

    Full Text Available Die Polis ist tot, es lebe die kreative Stadt! Während die Stadt, zumindest in Teilen des städtischen Raums, blüht und gedeiht, scheint die Polis im idealisierten griechischen Sinn dem Untergang geweiht; in diesem Verständnis ist sie der Ort der öffentlichen politischen Auseinandersetzung und demokratischen Unterhandlung und somit eine Stätte (oft radikaler Abweichung und Unstimmigkeit, an der die politische Subjektivierung buchstäblich ihren Platz hat. Diese Figur einer entpolitisierten (oder postpolitischen und postdemokratischen Stadt im Spätkapitalismus bildet das Leitmotiv des vorliegenden Beitrags. Ich lehne mich dabei an Jacques Rancière, Slavoj Žižek, Chantal Mouffe, Mustafa Dikeç, Alain Badiou und andere Kritiker jenes zynischen Radikalismus an, der dafür gesorgt hat, dass eine kritische Theorie und eine radikale politische Praxis ohnmächtig und unfruchtbar vor jenen entpolitisierenden Gesten stehen, die in der polizeilichen Ordnung des zeitgenössischen neoliberalen Spätkapitalismus als Stadtentwicklungspolitik [urban policy] und städtische Politik [urban politics] gelten. Ziel meiner Intervention ist es, das Politische wieder in den Mittelpunkt der zeitgenössischen Debatten über das Urbane zu stellen. [...

  14. Assisted Dying & Disability.

    Science.gov (United States)

    Riddle, Christopher A

    2017-07-01

    This article explores at least two dominant critiques of assisted dying from a disability rights perspective. In spite of these critiques, I conclude that assisted dying ought to be permissible. I arrive at the conclusion that if we respect and value people with disabilities, we ought to permit assisted dying. I do so in the following manner. First, I examine recent changes in legislation that have occurred since the Royal Society of Canada Expert Panel on End-of-Life Decision-Making report, published in this journal. I suggest that these changes are likely to only strengthen opposition to assisted dying from disability rights activists and people with disabilities. Second, I focus on respect for people with disabilities and in particular, respect for their autonomy and decision-making abilities. Third, I explore the opposition to assisted dying that focuses on risk and the vulnerability of people with disabilities. Here I suggest that this risk ought not to be of special concern. Ultimately, I conclude that upholding respect for the disabled requires the legalization of assisted dying, rather than the denial of access in a misguided effort to protect people with disabilities. © 2017 John Wiley & Sons Ltd.

  15. Diagnosis of rare diseases under focus: impacts for Canadian patients.

    Science.gov (United States)

    Esquivel-Sada, Daphne; Nguyen, Minh Thu

    2018-01-01

    This paper presents an in-depth qualitative analysis of the impact of diagnosis on the lives of rare disease (RD) patients. While diagnosis may be described as a watershed step for RD patients, no extensive account of non-medical outcomes following a RD diagnosis exists within the literature. This study aims to fill this knowledge gap through an analysis of the impact of diagnosis on the lives of RD patients according to their personal experiences. Qualitative research was conducted in three provinces across Canada, with a total of 23 participants, both adult and parents of children with RD, diagnosed and not yet diagnosed. A thematic approach guided the analysis of the transcripts. The results reveal that the impacts of a RD diagnosis for both adults and paediatric patients are multifold, ranging from social to personal and medical impacts (including cases where etiological treatments for the diseases are non-existent). Furthermore, the results shed light on distinct factors that affect the scope of impacts of a diagnosis.

  16. Die liefde wat die son beweeg en die ander sterre: Digterlike transendering – tot die vermenigvuldigde lewe ontroer

    Directory of Open Access Journals (Sweden)

    A.S. (Rensia Robinson

    2014-09-01

    Full Text Available T.T. Cloete se oeuvre word onder andere gekenmerk deur fyn waarneming van ’n mistieke vervlegtheid in die skepping. Dit word op vele maniere ontgin en geïnterpreteer. Die poëtiese potensiaal van die vrou, in uiteenlopende gestaltes, is een van die sentrale temas waardeur die digter hieraan vorm gee. In die kunstige, bibliofiele uitgawe Uit die wit lig van my land gesny val die lig op die vrou se kreatiewe rol in die groter skepping wat haar onder andere identifiseer as haarveer vir digterlike insig en vormgewing. Vrou (alternatief Anna Perenna, universele moeder, is nie slegs draer van die lewenskiem wat tot gees transendeer nie, maar sy funksioneer as ligbron (’sonvrou’ wat selfs kosmiese insig verwesenlik. Dit raak meervoudige vorms en patrone waarin die mens ingeweef is in die universele hologram van lewe. Vir die digter is hierdie patroonvorming vergelykbaar met die maak van Persiese tapyte waarvan die patrone vasgelê is in die geheue van voorouers, en oorgedra word na opeenvolgende geslagte. In dié verkenning word digterlike transendering ontgin as ’n proses waarin die kleurvolheid van lewe en dood in en deur individuele sowel as universele vroulikheid geïnspireer word.

  17. Die histologie en ultrastruktuur van die hepatopankreas van die bloukurper Oreochromis mossambicus

    Directory of Open Access Journals (Sweden)

    M. M. Nel

    1990-07-01

    Full Text Available Die histologie en ultrastruktuur van die hepatopankreas van die bloukurper Oreochromis mossambicus word beskryf. ’n Dun bindweefselkapsel omring die lewer. Die hepatosietrangskikking vertoon as lobules, met die koorde van hepatosiete wat vanaf ’n sentrale vene uitradieer en met mekaar anastomaseer. Indiwiduele lewerlohules vertoon nie duidelike grense nie, maar enkele duidelike triades word wel in die lewer van O. mossambicus aangetref. Die hepatosiete bevat ’n enkele ronde kern met ’n duidelike nukleolus en die growwe endoplasmiese retikula kom in twee of meer rye om die kerne en teen die selgrense van die hepatosiete voor. Die ander sitoplasmiese organelle kom verspreid in die hepatosietsitoplasma voor. Die eksokriene pankreasselle is om die portale venes gesetel. Die kerne van hierdie selle is rond en is hasaal in die kubies- tot silindervormige selle gelee. ’n Goedontwikkelde growwe endoplasmiese retikulum — vesikulêr, tubulêr en sirkulêr in vorm — en sektretoriese granules wat apikaal in die sel gelee is, kom voor.

  18. C. L. DIE UITDRUKKING „MAN VAN GOD” IN DIE BYBEL Die ...

    African Journals Online (AJOL)

    Test

    geskiedenis te volg, waarby ons egter telkens daaraan moet dink dat dit nie altyd die chronologiese volgorde van die Bybelse litteratuur is nie. Moses word op ses plekke 'n man van God genoem. Die eerste is. Deut. 33:1: „En dit is die seën waarmee Moses, die man van God, die kinders van Israel geseën het voor sy dood.

  19. Die afrikaner: definisie en konsep*

    Directory of Open Access Journals (Sweden)

    J. H. Coetzee

    1977-03-01

    Full Text Available Die uitnodiging om deel te necm aan hierdie simposium het tot gevolg gehad dat ek deurgaans meer gewonder het oor die vraag waaroin die wêreld as’t ware so behep geraak het met die Afrika­ ner as om ’n antwoord te vind op die vraag wat deur die tcma gesuggereer word, naamlik wie is die Afrikaner eintlik? As volkekundige het ek hierin iets van die dramatiese ironic ervaar deur te dink aan daardie volke wat so veelvuldig deur ons volkekundiges besoek en waargeneem word, dat dit tot verleentheid en ergerlikheid lei. In hierdie geval bevind ek my nou in albei rolle te wete die van etnoloog en van lid van die volk op wie die mcnigvuldige disseksies uitgevoer word.

  20. Konstitusionele ontwikkelinge in die transkei*

    Directory of Open Access Journals (Sweden)

    J. J. Henning

    1962-03-01

    Full Text Available Hoewel die Transkei met ’n oppervlakte van 16,000 vk. myl, die grootste aaneengeslote Banloeblok in Suid-Afrika is, is dit kleiner as sells die kleinste onafhanklike staal in Afrika, naamlik Togoland met ’n oppervlakte van 20,000 vk. myl. Word die distrik Glen Grey, wat geogra- fies ’n deel daarvan vorm, bygereken, beslaan dit 4Vi> miljoen morg wat ongeveer so groot is as Basoetoland plus die Bantoegedeelte van Swaziland. Die Transkei strek vanaf die Keirivier tot aan die Natalse suidelike grens en lê tussen die Drakensberge en die Indiese Oseaan en is feitlik net so n gebroke landskap as Natal; 15% van die gebied is berge, 40% baie bergagtig, 34% is Iienwelagtig en slegs 1.1% is plat en saggolwend.

  1. Die vrese van ons vaders

    Directory of Open Access Journals (Sweden)

    Anita Cloete

    Full Text Available Die boek fokus op die plek en rol van godsdiensonderrig in skole in die konteks van godsdiensvryheid as deel van 'n demokratiese bestel in Suid-Afrika. Die skrywer betoog teen die behoefte van veral die wit Afrikaner om Christelike godsdiens te gebruik om hulle te onderskei en te isoleer van ander. Christelike godsdiens word dus gebruik om te diskrimineer teen ander wat anders glo of ongelowig is. In dié sin gaan dit dus nie soseer oor die Bybel nie, maar eerder oor die beskerming van godsdiens as magsbasis om die belange van die Afrikaner te beskerm as die sogenaamde uitverkore volk. Godsdiens in skole word dus as 'n politieke wapen gebruik in 'n demokratiese bestel, waar alle mense ongeag ras, klas en godsdiens, regte het wat erken en beskerm moet word. Hierdie poging word ten sterkte teengestaan aangesien dit veral onvanpas is binne 'n demokratiese regeringstelsel.

  2. die aard van wetgewende diskresies by die suid-afrikaanse ...

    African Journals Online (AJOL)

    Administrator

    In enige moderne demokrasie is daar een of ander vorm van skeiding van magte tussen die wetgewende, uitvoerende en regsprekende gesag. Hierdie skeiding van magte, die sogenaamde trias politica, kan sover teruggevoer word as 1215, met die ondertekening van die Magna Carta deur Koning John van Engeland.

  3. op die veranderinge wat in die onderrig van Afrikaans plaasgevind ...

    African Journals Online (AJOL)

    8 Apr 2016 ... en letterkunde onderrigtegnieke, te bespreek. Die afdeling integreer nuttig die eise van die KABV beleidsdoku mente met die praktiese onderrig van. Afrikaans as Huistaal en as Eerste Ad disionele Taal op alle vlakke. Praktiese voorbeelde en oefeninge word telkens gebruik as illustrasie en dien om ...

  4. Die belangrikheid van sagteweefsel pedikels in beserings van die ...

    African Journals Online (AJOL)

    Die belangrikheid van sagteweefsel pedikels in beserings van die gesig. C. S. F. Smit. Abstract. Twee gevalle wat demonstreer dat die sagteweefsel pedikel van gedeeltelik geamputeerde weefsel in gesigbeserings behou moet word, word beskryf. Eenvoudige, praktiese maatreels om optimale bloedvloei deur die pedikel ...

  5. 'n Begronde bedieningsmodel vir die diakonia van die gemeente

    African Journals Online (AJOL)

    15 Feb 2012 ... reeds vir ongeveer drie jaar 'n bepaalde bedieningsmodel gevolg wat daarop gemik was om die gemeente toe te rus vir sy dienswerk, om onderlinge liefde in die gemeente te bevorder en uit te reik na buite. Die bedieningsmodel het in die gemeente as 'mekaar-bediening' of 'lidmate-kerk' bekend gestaan.

  6. DIE STAD IN DIE ISRAELITIESE VOORSTELLINGSLEWE. Een van ...

    African Journals Online (AJOL)

    Test

    'n Pleknaam soos Kir-Moab,. ,,muur van Moab" (Jes. 15:1) kan dan vergelyk word met 'n reeks van. Assiriese name wat met duru ,,muur" saamgestel is. Die grondgedagte agter die verskillende woorde voor „stad" sou dan steeds dieselfde wees, naamlik die van „muur", en daarmee sou dan die gedagte van veiligheid,.

  7. die doeltreffendheid van die afrikaanse woordelys en spelreels

    African Journals Online (AJOL)

    sluiting by die reel vir die verdubbeling van medeklinkers na 'n kort, be- klemtoonde klinker, woorde soos ballet, ballon, terras, terrein, dissipel en dissipline slegs met een konsonant na die eerste vokaal gespel moes word, omdat daardie voorafgaande vokaal onbeklemtoon is. Ook hierdie uit- sondering op die reel word ...

  8. Vertellersperspektief en die 'temporele' funksie van die Ou ...

    African Journals Online (AJOL)

    evangelie; Waar Markus teen die ... Die einde van die Matteus-evangelie is dus oop, want nadat die epog van Jesus afgesluit is, het 'n ...... Language usage and the production of Matthew 1:18-2:23, in Spencer. RA (ed). Orientation by disorientation.

  9. Stuttgart, 1952. DIE HUIDIGE STAND VAN DIE ONDERSOEK TEN ...

    African Journals Online (AJOL)

    Test

    . Die Amerikane het hulle nie daarvoor geïnteresseer nie. Kort daarop het die handelaar, inmiddels na Europa teruggekeer, gesterf. Tot op die stadium het niemand nog met sekerheid geweet wat die codices presies bevat nie. Alleen o.g.v. 'n ...

  10. Die aanspraak op Goddelike steun in 'n konfliksituasie volgens die ...

    African Journals Online (AJOL)

    laws, and ethical or political principles. A synchronic investigation of relevant Old ... die toneel gebring met die vraag: 'aan wie se kant is God' (vgl bv The road to. Damascus 1979:6)? Volgens .... betrekking tot die Ou Testament: Hoe moet ons vasstel wie se kant God nou regtig kies, of wie veg aan die kant van God en wie ...

  11. die eerste vrydeidsoorlog: enkele aspekte mbt die britse siening van ...

    African Journals Online (AJOL)

    rees in die Vereenigde. Staten van. Noord-Amerika. Dan zal het zijn van Zambezi tot aan Simonsbaai: Afrika voor den Afrikaner'.16. Die Boere het op hul beurt ook die Britse soldate met 'n mate van geamuseerdheid beskou. Dit was vir hulle onverstaanbaar dat die Engelse oral te voet met swaar pakke uitrusting op hul rOe.

  12. Die kerk en die kommunisme, uitgangspunt en perspektief

    Directory of Open Access Journals (Sweden)

    A. H. Murray

    1970-06-01

    Full Text Available Waar ons onmiddellike opdrag is om die konkrete taak van die kerk in die bestryding van Kommunisme en Marxisme te beskrywe, is ons gedwing om terug te dink aan die eerste grondslae van die vyandelike aanslag — die grondslae waarop sy leer en sy beleid van gewelddadige optrede berus. Want ons het nie te doen met ’n opportunistiese onderneming of ’n imperialistiese waagstuk as dit oor die Kommunisme gaan nie, en ook nie met die blinde opbruising van laere en agterlike volksklasse nie, maar wel met ’n deurdagte en afgeronde heelal-filosofie wat oor die aardbol versprei is en wat op sistematiese wyse en met wetenskaplike strategie ’n aanval op die bestaande Christelike orde maak.

  13. Die huwelik as identiteitsmerker in die Ou Testament

    African Journals Online (AJOL)

    p1243322

    Gen 2:18). Uit die woorde van Genesis 2:24 dat man en vrou een sal wees, lei die derde formulier af dat dit “getuig dat die huwelik 'n allesinsluitende gemeenskap is ..... die formule gebruik word: “Hier volg die vertelling oor X se nageslag.” (Gen ..... verwys daarna as “intertwining the principal value concepts of tradition”.

  14. DIE HEDENDAAGSE SIENING VAN DIE NORMERING VAN DUITS ...

    African Journals Online (AJOL)

    taal) in Mannheim, in 1964 ges^tig en met takkantore in Bonn, Kiel en Inns-. b r u c k . D i e I n s t i t u t s t e l .... J 4. Ouitstalige (deel van) Switserland. In die Duitstalige deel van Switserland word die Duden-spelreels amptelik as bindend erken. Die enigste uitsondering is dat die simbool p vervang is deur die skryfwyse ss.

  15. DIE PROBLEMATIEK VAN MILITERE OPLEIDING

    African Journals Online (AJOL)

    administratiewe, tegnologiese, ekonomiese, diplomatieke, politieke en opvoed- kundige aktiwiteite. So bestaan 'n tipiese leeror- ganisasie in die SAW uit stafafdelings wat ver- antwoordelik is vir die ondersteunende funksies en vegtende eenhede bekend as die Iynfunksie. Die vegtende eenhede is suiwer volgens funk-.

  16. DIE LEWE VAN JOAO ALBASINI

    African Journals Online (AJOL)

    Dit het gou geblyk dat die jong Albasini nie 'n tekort aan avonture sou ondervind nie. In 1834, word Lourenco Marques deur die Zoeloe Impi's van koning Soshangane binnegeval en geplun- der. AI die blanke nedersetters is wreed vermoor behalwe Albasini, wat hom as kranksinnig voor- gedoen het en deur die Zoeloes na ...

  17. Das Messiasgeheimnis und die Spruchquelle

    African Journals Online (AJOL)

    p1243322

    die dies Logion redaktionell an die vorangehende christologische Aussage anschließt, begegnet dabei expressis verbis das markinische Motiv der esoterischen Jüngerbelehrung. Das Geheimnis der Person Jesu offenbart. Jesus exklusiv seinen Jüngern. Die Wendung entspricht wortgleich den gleichsinnigen Aussagen, ...

  18. PRETORIA GEDURENDE DIE EERSTE VRYDEIDSOORLOG

    African Journals Online (AJOL)

    Teen die einde van 1880 het hierdie oplewing onder die. Transvalers 'n hoogtepunt bereik toe tydens die vergadering by Paardekraal op 8 Desember 1880 besluit is om tot die ... hulle in Transvaal en veral in Pretoria gevestig sodat daar teen Maart ..... admiration, for they have the additional anxiety to bear in knowing that ...

  19. Voedingsnavorsing met die weidende dier

    African Journals Online (AJOL)

    van veral beeste (Bisschop, 1964; Niemann, Lombard & Van. Schalkwyk, 1963). In teenstelling met die relatiewe groot hoeveelheid inligting oor die chemiese samestelling van natuurlike weidings, is daar betreklik min bekend oor die verteerbaarheid en vrywillige in- name daarvan deur herkouers. 'n Skerp daling in die ...

  20. Narratiwiteit en die Ou Testament

    African Journals Online (AJOL)

    INLEIDING. Die literêre benadering tot die Ou-Testamentiese narratiewe word algemeen as 'n alternatiewe paradigma in die Bybelwetenskappe aanvaar. Oor die filosofiese uit- gangspunte wat hierdie nuwe paradigma ten grondslag lê, bestaan daar egter nog weinig eenstemmigheid. Heelwat probleme van filosofiese en ...

  1. Oor die verhouding tussen woordeboekstrukture ...

    African Journals Online (AJOL)

    R.B. Ruthven

    Rufus H. Gouws, Departement Afrikaans en Nederlands, Universiteit van. Stellenbosch, Stellenbosch, Republiek van Suid-Afrika (rhg@sun.ac.za). Opsomming: Navorsing op die gebied van die metaleksikografie het oor die laaste paar dekades 'n betekenisvolle fokusverbreding ondergaan. Die aanvanklike fokus was veral ...

  2. Wêreldgebeure gedurende die jaar 1954.

    Directory of Open Access Journals (Sweden)

    S. du Toit

    1954-03-01

    Full Text Available Die jaar 1954 het begin sonder Stalin, die magtigste diktator van die modeme tyd, en dit wa s nog onseker hoe die nuwe regime sou optree.Teen die einde van die ja a r weet ons nou dat hulle oënskynlik meer toeskietlik is maar in wese nog net so geheimsinnig en nog net so geslepe. Die Petrof-gesjriedenis in Australië het weereens laat blyk dat daar oordie hele aarde ’n netwerk van spioene is.

  3. Productivity of agricultural surfaces in the eastern parts of Germany under the influence of climatic changes; Die Ertragsfaehigkeit ostdeutscher Ackerflaechen unter Klimawandel

    Energy Technology Data Exchange (ETDEWEB)

    Wechsung, Frank; Gerstengarbe, Friedrich-Wilhelm; Lasch, Petra; Luettger, Andrea (eds.)

    2008-12-15

    statistical yield models relating yearly changes in major climate variables to those in crop yield at the county level. The models were calibrated for the period 1990 to 2006 and then used for simulating the climate dominated yield variability beginning in 1951 up to 2055. The results received after integration revealed that the climate-determined yield level will probably remain stable under the projected climatic conditions for the next 20 to 30 years. A significant yield loss is to be expected by the middle of the 21st century, especially at locations in the eastern sandy lowlands distant from coast and mountain regions. The losses will be greater in the cultivation of the summer crop maize than that of the winter crop wheat. However, the increase in atmospheric concentration of carbon dioxide (CO2) might compensate part or all of these losses. Due to the fertilizing effect of this greenhouse gas, yields of wheat can even be expected to increase above current levels and yield losses of maize due to water stress will be mostly diminished. An optimum nitrogen provision is a necessary precondition for the CO2 fertilization to come to its full effect, though. In contrast to wheat and maize, yields of fast growing aspen in short rotation coppice plantation are expected to increase under the presumed changes of climate also on sandy soils with low water holding capacity even when neglecting the beneficial effect of higher CO2. This is indicated by simulation results using the eco-physiological forest dynamics model 4C. The model was applied to those areas of East-Germany's arable land where cereal cropping is less productive than the current median level. Following these results, short rotation coppicing of aspen is a promising cultivation alternative for farmers to secure future incomes. Woody biomass generated in short rotation coppice plantations with aspen is particularly suitable for bio-energy production. Taken the simulated effects of the projected climate change on

  4. Under-ascertainment of Aboriginality in records of cardiovascular disease in hospital morbidity and mortality data in Western Australia: a record linkage study

    Directory of Open Access Journals (Sweden)

    Katzenellenbogen Judy M

    2010-12-01

    Full Text Available Abstract Background Measuring the real burden of cardiovascular disease in Australian Aboriginals is complicated by under-identification of Aboriginality in administrative health data collections. Accurate data is essential to measure Australia's progress in its efforts to intervene to improve health outcomes of Australian Aboriginals. We estimated the under-ascertainment of Aboriginal status in linked morbidity and mortality databases in patients hospitalised with cardiovascular disease. Methods Persons with public hospital admissions for cardiovascular disease in Western Australia during 2000-2005 (and their 20-year admission history or who subsequently died were identified from linkage data. The Aboriginal status flag in all records for a given individual was variously used to determine their ethnicity (index positive, and in all records both majority positive or ever positive and stratified by region, age and gender. The index admission was the baseline comparator. Results Index cases comprised 62,692 individuals who shared a total of 778,714 hospital admissions over 20 years, of which 19,809 subsequently died. There were 3,060 (4.9% persons identified as Aboriginal on index admission. An additional 83 (2.7% Aboriginal cases were identified through death records, increasing to 3.7% when cases with a positive Aboriginal identifier in the majority (≥50% of previous hospital admissions over twenty years were added and by 20.8% when those with a positive flag in any record over 20 years were incorporated. These results equated to underestimating Aboriginal status in unlinked index admission by 2.6%, 3.5% and 17.2%, respectively. Deaths classified as Aboriginal in official records would underestimate total Aboriginal deaths by 26.8% (95% Confidence Interval 24.1 to 29.6%. Conclusions Combining Aboriginal determinations in morbidity and official death records increases ascertainment of unlinked cardiovascular morbidity in Western Australian

  5. DIE KERKLIKE TUG * Die tug en die handhawing daarvan is n saak ...

    African Journals Online (AJOL)

    Test

    Waar eersgenoemde deur kerklike amps draers bedien word, daar word laasgenoemde deur die wêreldlike ower- heid bedien/) Die ampsdraers wat Christus aan sy gemeente gee^) beoefen die kerklike tug met geestelike wapens van oortuiging, verma ning, berisping, sensuur en ban/) Die wêreldlike owerheid daarenteen.

  6. Die uitbouing van die Bybelse kanon in antieke Judaïsme en die ...

    African Journals Online (AJOL)

    31 Jul 2015 ... Vergelyk Eusebius, 'n anti-Marcionitiese skrywer wat in 192/3 n.C. werk; Historia. Ecclesiasfica V 17, 2. verder gestimuleer is. Talle nuwe geskrifte het die lig gesien waaroor die kerk besluite moes neem en waarteen die kerk afgrensings moes doen. Vroeë omlyning van die versameling van boeke.

  7. Matteus se eskatologie as die koninkryk van die hemel wat reeds ...

    African Journals Online (AJOL)

    p1243322

    die sosioloog Pierre Bourdieu (1963:55-72): “Die tydsverloop waaruit die hede bestaan, is die geheel van 'n aksie gesien in die eenheid van 'n persepsie wat beide die verlede wat onthou word en die verwagte toekoms insluit. Die 'hede' van 'n aksie omvat, buiten die waargenome hede, 'n horison van die verlede en van ...

  8. Calvyn en die Calvinisme

    African Journals Online (AJOL)

    Gutenberg. BARR, J 1962. Biblical words for our time. London: SCM. BARR, J 1977. Fundamentalism. London: SCM. BIJLSMA, R 1959. Schriftuurlijk Schriftgezag. Nijkerk: Callenbach. BOTHA, SJ 1973. Die volkskerk. Pretoria: HAUM. BOYER, L 1963. The Spirit and forms of Protestantism. London: Fontana Library (Collins).

  9. Die Kosmologie der Griechen.

    Science.gov (United States)

    Mittelstraß, J.

    Contents: 1. Mythische Eier. 2. Thales-Welten. 3. "Alles ist voller Götter". 4. Griechische Astronomie. 5. "Rettung der Phänomene". 6. Aristotelische Kosmololgie. 7. Aristoteles-Welt und Platon-Welt. 8. Noch einmal: die Göttlichkeit der Welt. 9. Griechischer Idealismus.

  10. Biografie in die pryslied

    African Journals Online (AJOL)

    hond

    7 Apr 2007 ... From this analysis it becomes clear to what extent Krog applies the conventions and means of the traditional Xhosa praise poem in her poem. .... met poetryof oral poetry. Dit is egter moeilik om die term “pryslied” ..... Really, the honey-bird is never without plans. 41. I wonder what the students of this nations ...

  11. Die skool en die onderwyser as faktore in die geestesgesondheid van die kind*

    Directory of Open Access Journals (Sweden)

    B. C. Schutte

    1961-03-01

    Full Text Available Ons hou geestesgesondheidsweke, stig beroepsentrums, samel geld in om mense wat geestelik siek is te genees, klae oor die tekort aan psigiaters, kliniese sielkundiges, bedryfsielkundiges, voorligters, skoolpsigoloë,ens. ’n Karige kwarteeu gelede het ons aan al hierdie dinge slegs akademiese aandag gewy. In hierdie kursus wordverskeie tipes kinders bespreek en geleer hoe om hulle probleme te benader.

  12. Die Kunst des Scheiterns

    DEFF Research Database (Denmark)

    Juul, Jesper

    2014-01-01

    Menschen haben von Kindesbeinen an das Verlangen, Erfolge zu erzielen und Kompetenz zu erreichen. Computerspieler entscheiden sich jedoch fortlaufend für eine Aktivität, die oft und wiederholt zum Verlieren führen muss und ein taubes Gefühl der Unfähigkeit erzeugt. Im Kino, im Theatersaal und bei...

  13. Soybean (Glycine max L. Merr.) Sprouts Germinated under Red Light Irradiation Induce Disease Resistance against Bacterial Rotting Disease

    OpenAIRE

    Dhakal, Radhika; Park, Euiho; Lee, Se-Weon; Baek, Kwang-Hyun

    2015-01-01

    Specific wavelengths of light can exert various physiological changes in plants, including effects on responses to disease incidence. To determine whether specific light wavelength had effects on rotting disease caused by Pseudomonas putida 229, soybean sprouts were germinated under a narrow range of wavelengths from light emitting diodes (LEDs), including red (650-660), far red (720-730) and blue (440-450 nm) or broad range of wavelength from daylight fluorescence bulbs. The controls were co...

  14. In enige vleisproduksieondememing is die maksimum hoeveelheid ...

    African Journals Online (AJOL)

    Die M. biceps femoris van die boud en flexor· en extensor-spiere van die voorbeen is ook uit die linkersy gedissekteer, fisies ontvet en geweeg (Butter· field, 1963) om sodoende die totale spiermassa van die karkas te bereken. Die radius ulna· en metacarpalbene van die linkervoorbeen is ook skoon geskraap en geweeg.

  15. Modelle in die onderrig van fisika

    Directory of Open Access Journals (Sweden)

    J. J. A. Smit

    1998-07-01

    Full Text Available Die rol van modelle in die onderrig van fisika is sedert die vroeë tagtigerjare erken. In die onderrig word die absent op die kwantitaiewe aspekte van die vak geplaas, terwyl die kwatitatiewe aspekte min aandag kry.

  16. DIE SAGD - SY ONTSTAAN EN ONTWIKKELING

    African Journals Online (AJOL)

    31 Okt 1977 ... stelling van 'n higiene afdeling het in 'n belang- rike behoefte voorsien. Die pligte van die SAGO het dus op hierdie stadium die ondersoek van soldate, die sanita- sie van kampe, die verpleging van pasiente in militere hospitale en die opleiding van lede be- hels. 'n Hoogtepunt was die opening van die.

  17. Die skeppingsmites as simbole van psigiese prosesse

    African Journals Online (AJOL)

    dig aangedui met 'n tekening van die Uroboros, die slang wat sy eie stert eet. Die antieke kaart word verder versier met tekeninge van diere, monsters en demoniese figure. Vier koppe met monde wat die wind uit die vier windrigtings blaas, word in die hoeke van die kaart geteken. Die Uroboros, diere, monsters en demone ...

  18. Is God (inkonsekwent? Heerskappy, oorweging en aanspreeklikheid in die Dawidsgeskiedenis in die boeke van Samuel

    Directory of Open Access Journals (Sweden)

    Jaap L. Helberg

    2014-03-01

    Full Text Available As ’n eenheid openbaar die Samuelboeke die aanspreeklikheid van mense in hulle verhouding tot mekaar en tot God. Hierdie artikel ondersoek die vraag na God se konsekwentheid wat ook die vraag impliseer of alles onder sy heerskappy plaasvind. Die bevinding is dat alles onder God se allesoorkoepelende, vrymagtige en persoonlike heerskappy gebeur. Vir die beperkte menslike oorweging is dit geheel en al onpeilbaar anders. Dit is nie ’n nuutskepping oor sy Woord wat die lig bring nie, maar die nuutontdekking in sy Woord. Hy laat reg en geregtigheid geld, maar in ’n nog sterker mate ook sy genade. Uiteindelik is sy konsekwentheid – ‘die dwaasheid van die kruis’ – ten volle geopenbaar in die verwagte Messias, Jesus Christus. In die huidige stukkende werklikheid oefen God ook sy heerskappy uit deur persone wat hulle eie agendas het, selfs bose agendas. So laat Hy gelowiges tot selfontdekking, berou en bekering oor hulle sonde kom. Hulle leef met kinderlike vertroue op God en volgens die groot gebod van die liefde. The books of Samuel as a unity reveal the accountability of people in their relations to each other and to God. This article explores the issue of God’s consistency, including the question whether everything happens under his reign. The finding is that everything happens under his all-embracing, all-powerful and personal sovereignty, which is unfathomable by the limited human deliberation. It is not a new creation about his Word which brings the light, but the new discovery in his Word. He asserts justice, and to an even greater extent, his grace. His consistency – ‘the foolishness of the cross’ – is ultimately fully revealed in the expected Messiah, Jesus Christ. In the present broken reality God also asserts his sovereignty through people who have their own agendas, even evil agendas. Thus, He brings believers to self-discovery, remorse and repentance from their sins. They live with childlike trust in God and

  19. Experimental Investigations of the In-Die Quenching Efficiency and Die Surface Temperature of Hot Stamping Aluminium Alloys

    Directory of Open Access Journals (Sweden)

    Kailun Zheng

    2018-04-01

    Full Text Available The in-die quenching is a key stage in the hot stamping volume production chain which determines the post-formed strength of lightweight alloy components, tool life, and hot stamping productivity. In this paper, the performance of in-die quenching, reflected by the quenching efficiency (the time of work-piece held within stamping dies and die surface temperature during the simulated hot stamping process of AA6082, was experimentally and analytically investigated. A range of in-die quenching experiments were performed for different initial work-piece and die temperatures, quenching pressures, work-piece thickness, and die clearances, under hot stamping conditions. In addition, a one-dimensional (1D closed-form heat transfer model was used to calculate the die surface temperature evolution that is difficult to obtain during practical manufacture situations. The results have shown that the in-die quenching efficiency can be significantly increased by decreasing the initial work-piece and die temperatures. Die clearances are required to be designed precisely to obtain sufficiently high quenching rates and satisfying post-formed strength for hot-stamped panel components. This study systematically considered an extensive variety of influencing factors on the in-die quenching performance, which can provide practical guides for stamping tool designers and manufacture systems for hot-stamping volume production.

  20. enkele aantekeninge by die debat oor die uitleg van die dordtse ...

    African Journals Online (AJOL)

    Test

    tussen Ds. Murray en Ds. Kotzé van Darling oor die uitleg van die Dordtse. Leerreëls gevoer is, 'n ander mening ... zijn zal, die het wapen ter verdediging van het leerstuk der Praedesti- natie gelijk het door de Dordsche .... In plaas daarvan om die pennestryd op die voet te volg, wil ek sowel. Ds. Kotzé as Ds. Murray se ...

  1. T.T. Cloete en die omdigting van die Psalms

    Directory of Open Access Journals (Sweden)

    M. Venter

    1996-06-01

    Full Text Available Sedert 1989 is T.T. Cloete saam met ander digters werksaam aan die omdigting van die Psalms - ’n taak wat, soos hy self sê, ’n nuwe dimensie in sy lewe ingedra het, maar ook ’n taak wat buitengewone eise stel: eksegeties en hermeneuties moet die Skrifgegewe in die omdigting met omsigtigheid vertolk word, die struktuurpatrone van die grondtaal moet nie onnodig versteur word nie en die eindproduk moet musikologies en harmonies aanvaarbaar op die oor val. In hierdie opsig is die bestaande Geneefse melodie soms ’n verdere dwangmeester wat die verslengte en die strofebou bepaal. Waar ook die melodie in berekening gebring moet word, moet hierdie ‘ruimte’ sinvol ‘ingevul’ word met Skrifgetroue inhoud. En wat poëties, semanties en taalkundig ‘normaal’ is, is nie altyd singbaar nie - die omdigtings moet uiteindelik in aldagtaal gesing word. Woorde, betekenisnuanses, verse en lettergrepe moet dus letterlik en figuurlik geweeg en getel word.

  2. Die Calvinistiese Sondagbeskouing met spesiale verwysing na ...

    African Journals Online (AJOL)

    omver te werp. Aan die ander kant het die orde en vrede in die kerk dit wel ook nodig gemaak om 'n dag vir gebruik van die diens van die Here af te sonder. Calvyn se insigte in verband met die oorgang van die Sabbat na die Sondag, is die insigte wat as die eg reformatoriese behoue gebly het. Haitjema (1961:249) sê in.

  3. Die historiese betroubaarheid van die aartsvadervertellinge. 'n Beknopte bespreking van die huidige debat na aanleiding van die jongste publikasie

    Directory of Open Access Journals (Sweden)

    W. Vosloo

    1982-08-01

    Full Text Available Die afgelope twintig jaar was daar �n toenemende belangstelling in die aartsvadervertellinge in Genesis. Benewens die talle tydskrifartikels het skrywers soos die volgende ook boeke oor die onderwerp die lig laat sien: A. Parrot (1962, W. M. Clark (1964, R. Kilian (1966, R. E. Clements (1967, N. Lohfink (1967, H. Weidemann (1968, R. Martin-Achard (1969, T. L. Thompson (1974, J. van Seters (1975, J. P. Fokkelman (1975, C. Westermann (1976, R. Rendtorff (1977, J. Bright (1977, W. McKane (1979 en A. R. Millard en D. J. Wiseman (1980.

  4. Die taalkommissie van die Suid-Afrikaanse akademie vir wetenskap ...

    African Journals Online (AJOL)

    Die Taalkommissie van die Suid-Afrikaanse Akademie vir Wetenskap en Kuns. Afrikaanse Woordelys en Spelreëls. Negende, verbeterde en omvattend herbewerkte uitgave. 2002, 592 pp. ISBN 1 86890 034 7. Kaapstad: Pharos Woordeboeke. Prijs: R170.

  5. Bismarck, Prim, die Sigmaringer Hohenzollern und die spanische Thronfrage

    OpenAIRE

    Becker, Josef

    1982-01-01

    Bismarck, Prim, die Sigmaringer Hohenzollern und die spanische Thronfrage : zum Fund von "Bismarcks Instruktionsbrief für Bucher" vom 25. Juni 1870 in d. "Real Acad. de la Historia", Madrid. - In: Francia. 9. 1981 (1982). S. 435-472

  6. Soybean (Glycine max L. Merr.) sprouts germinated under red light irradiation induce disease resistance against bacterial rotting disease.

    Science.gov (United States)

    Dhakal, Radhika; Park, Euiho; Lee, Se-Weon; Baek, Kwang-Hyun

    2015-01-01

    Specific wavelengths of light can exert various physiological changes in plants, including effects on responses to disease incidence. To determine whether specific light wavelength had effects on rotting disease caused by Pseudomonas putida 229, soybean sprouts were germinated under a narrow range of wavelengths from light emitting diodes (LEDs), including red (650-660), far red (720-730) and blue (440-450 nm) or broad range of wavelength from daylight fluorescence bulbs. The controls were composed of soybean sprouts germinated in darkness. After germination under different conditions for 5 days, the soybean sprouts were inoculated with P. putida 229 and the disease incidence was observed for 5 days. The sprouts exposed to red light showed increased resistance against P. putida 229 relative to those grown under other conditions. Soybean sprouts germinated under red light accumulated high levels of salicylic acid (SA) accompanied with up-regulation of the biosynthetic gene ICS and the pathogenesis- related (PR) gene PR-1, indicating that the resistance was induced by the action of SA via de novo synthesis of SA in the soybean sprouts by red light irradiation. Taken together, these data suggest that only the narrow range of red light can induce disease resistance in soybean sprouts, regulated by the SA-dependent pathway via the de novo synthesis of SA and up-regulation of PR genes.

  7. Soybean (Glycine max L. Merr. sprouts germinated under red light irradiation induce disease resistance against bacterial rotting disease.

    Directory of Open Access Journals (Sweden)

    Radhika Dhakal

    Full Text Available Specific wavelengths of light can exert various physiological changes in plants, including effects on responses to disease incidence. To determine whether specific light wavelength had effects on rotting disease caused by Pseudomonas putida 229, soybean sprouts were germinated under a narrow range of wavelengths from light emitting diodes (LEDs, including red (650-660, far red (720-730 and blue (440-450 nm or broad range of wavelength from daylight fluorescence bulbs. The controls were composed of soybean sprouts germinated in darkness. After germination under different conditions for 5 days, the soybean sprouts were inoculated with P. putida 229 and the disease incidence was observed for 5 days. The sprouts exposed to red light showed increased resistance against P. putida 229 relative to those grown under other conditions. Soybean sprouts germinated under red light accumulated high levels of salicylic acid (SA accompanied with up-regulation of the biosynthetic gene ICS and the pathogenesis- related (PR gene PR-1, indicating that the resistance was induced by the action of SA via de novo synthesis of SA in the soybean sprouts by red light irradiation. Taken together, these data suggest that only the narrow range of red light can induce disease resistance in soybean sprouts, regulated by the SA-dependent pathway via the de novo synthesis of SA and up-regulation of PR genes.

  8. Modeling the Mechanical Performance of Die Casting Dies

    Energy Technology Data Exchange (ETDEWEB)

    R. Allen Miller

    2004-02-27

    The following report covers work performed at Ohio State on modeling the mechanical performance of dies. The focus of the project was development and particularly verification of finite element techniques used to model and predict displacements and stresses in die casting dies. The work entails a major case study performed with and industrial partner on a production die and laboratory experiments performed at Ohio State.

  9. Die landsbelofte en grondbesit: Enkele perspektiewe op die boek ...

    African Journals Online (AJOL)

    Hulle begeer 'n stuk grond en vat dit, huise, en lê beslag daarop. Hulle kul 'n man uit sy huis uit,. 'n mens uit sy besitting uit. (Miga 2:1-2). Miga protesteer teen die wyse waarop die leiers die mense uitbuit deur hulle grond en eiendom van hulle af te vat. Die vraag mag onstaan waarom dit as uitbuiting gesien is en daarom ...

  10. [What do adults die in Mexico? Impact on the economic and social development of the nation. The global burden of cardiovascular disease].

    Science.gov (United States)

    Rosas-Peralta, Martín; Arizmendi-Uribe, Efraín; Borrayo-Sánchez, Gabriela

    2017-01-01

    Noncommunicable diseases have been established as a clear threat, not only to human health but also to the development and economic growth. Claiming 63% of all deaths, these diseases are currently the main murderer worldwide. The increase in the prevalence and importance of noncommunicable diseases specifically of cardiovascular risk factors such as hypertension, diabetes, dyslipidemia and obesity is the result of a complex interplay between health, economic growth and development, which is strongly associated with universal trends such as the aging of the world population, rapid unplanned urbanization, and the globalization of unhealthy lifestyles.Cardiovascular disease refers to a group of diseases involving the heart, blood vessels, or the consequences of poor blood supply due to a vascular source ill. About 82% of the burden of mortality is caused by ischemic heart disease or coronary heart disease (IHD), Stroke (both hemorrhagic and ischemic), hypertensive heart disease or congestive heart failure (CHF). The Hospital de Cardiología of the Centro Médico Nacional Siglo XXI, serves the call to improve through innovation and technological development this area of health the "tele cardiology" (regulatory center of myocardial code), with clear objectives in the short, medium and long term.

  11. Forecasting the future risk of Barmah Forest virus disease under climate change scenarios in Queensland, Australia.

    Directory of Open Access Journals (Sweden)

    Suchithra Naish

    Full Text Available BACKGROUND: Mosquito-borne diseases are climate sensitive and there has been increasing concern over the impact of climate change on future disease risk. This paper projected the potential future risk of Barmah Forest virus (BFV disease under climate change scenarios in Queensland, Australia. METHODS/PRINCIPAL FINDINGS: We obtained data on notified BFV cases, climate (maximum and minimum temperature and rainfall, socio-economic and tidal conditions for current period 2000-2008 for coastal regions in Queensland. Grid-data on future climate projections for 2025, 2050 and 2100 were also obtained. Logistic regression models were built to forecast the otential risk of BFV disease distribution under existing climatic, socio-economic and tidal conditions. The model was applied to estimate the potential geographic distribution of BFV outbreaks under climate change scenarios. The predictive model had good model accuracy, sensitivity and specificity. Maps on potential risk of future BFV disease indicated that disease would vary significantly across coastal regions in Queensland by 2100 due to marked differences in future rainfall and temperature projections. CONCLUSIONS/SIGNIFICANCE: We conclude that the results of this study demonstrate that the future risk of BFV disease would vary across coastal regions in Queensland. These results may be helpful for public health decision making towards developing effective risk management strategies for BFV disease control and prevention programs in Queensland.

  12. Forecasting the future risk of Barmah Forest virus disease under climate change scenarios in Queensland, Australia.

    Science.gov (United States)

    Naish, Suchithra; Mengersen, Kerrie; Hu, Wenbiao; Tong, Shilu

    2013-01-01

    Mosquito-borne diseases are climate sensitive and there has been increasing concern over the impact of climate change on future disease risk. This paper projected the potential future risk of Barmah Forest virus (BFV) disease under climate change scenarios in Queensland, Australia. We obtained data on notified BFV cases, climate (maximum and minimum temperature and rainfall), socio-economic and tidal conditions for current period 2000-2008 for coastal regions in Queensland. Grid-data on future climate projections for 2025, 2050 and 2100 were also obtained. Logistic regression models were built to forecast the otential risk of BFV disease distribution under existing climatic, socio-economic and tidal conditions. The model was applied to estimate the potential geographic distribution of BFV outbreaks under climate change scenarios. The predictive model had good model accuracy, sensitivity and specificity. Maps on potential risk of future BFV disease indicated that disease would vary significantly across coastal regions in Queensland by 2100 due to marked differences in future rainfall and temperature projections. We conclude that the results of this study demonstrate that the future risk of BFV disease would vary across coastal regions in Queensland. These results may be helpful for public health decision making towards developing effective risk management strategies for BFV disease control and prevention programs in Queensland.

  13. Dying for Security

    Directory of Open Access Journals (Sweden)

    Bruce Buchan

    2011-03-01

    Full Text Available If political statements and media coverage are any guide, it seems Australians today are dying for security. At no other moment in our history has the spectre of war and terrorism so haunted popular, political and scholarly perceptions of Australia’s colonial past and of its geopolitical future. And yet, debates over colonial war or genocide and contemporary terrorism have been conducted in more or less complete isolation. In this article I argue that our contemporary obsession with ‘security’ is premised on the perennial threat of ‘insecurity’. This is the problem of in/security, and it has played a central role in the development of Western political thought. More importantly, its formulation in Western political thought provided a powerful justification for the violence of the early decades of Australia’s colonisation during which Indigenous Australians could also be said to have been dying for security.

  14. Film Presentation: Die Urknallmaschine

    CERN Multimedia

    Carolyn Lee

    2010-01-01

    Die Urknallmaschine, an Austrian film by Gerd Baldauf, narrated by Norbert Frischauf (Alpha Österreich - ORF, 2009).  In CERN’s gigantic complex particles are accelerated to almost the speed of light, brought to collision and made to divide into even smaller particles. Public opinion of CERN’s research is also divided. Sceptics fear that black holes may be created. Might the goal to study the origin of the world lead to its destruction? The Austrian researcher Norbert Frischauf worked at CERN for many years. With his guidance it is possible to explore the world’s largest research centre, get a glimpse of the fascinating work the scientists do there and take a crash course in particle physics. Die Urknallmaschine will be presented on Friday, 25 June from 13:00 to 14:00 in the Main Auditorium. Language: German

  15. Metabolic Networks Underlying Cognitive Reserve in Prodromal Alzheimer Disease: A European Alzheimer Disease Consortium Project

    NARCIS (Netherlands)

    Morbelli, S.; Perneczky, R.; Drzezga, A.; Frisoni, G. B.; Caroli, A.; van Berckel, B.N.M.; Ossenkoppele, R.; Guedj, E.; Didic, M.; Brugnolo, A.; Naseri, M.; Sambuceti, G.; Pagani, M.; Nobili, F.

    2013-01-01

    This project aimed to investigate the metabolic basis for resilience to neurodegeneration (cognitive reserve) in highly educated patients with prodromal Alzheimer disease (AD). Methods: Sixty-four patients with amnestic mild cognitive impairment who later converted to AD dementia during follow-up,

  16. Die waarde en uitdagings van diensleer vir tolkopleiding: die ...

    African Journals Online (AJOL)

    Studente behoort op so ʼn wyse na te dink oor die diensleeraktiwiteit dat hulle verdere begrip van en groter waardering vir die dissipline kry, sowel as ʼn verhoogde bewustheid van persoonlike eiewaarde en verantwoordelikheid teenoor die burgerlike samelewing ontwikkel (Bringle en Hatcher 1995:12). Teen hierdie ...

  17. voorveronderstellings in die hantering van die verhouding tussen ou ...

    African Journals Online (AJOL)

    vgl. Bright 1967:184-196; Van Zyl. 1970; Baker 1976; Gese 1977; Odendaal 1979; Hasel 1987:145-169;. Snyman 1988b), moet die implikasies van die stelling uitgespel word: Ou en Nuwe Testament is gelykelik deel van die Christelike kanon.

  18. besonderhede aangaande in aantal geboue op die terrein van die ...

    African Journals Online (AJOL)

    'n Offisiersgebou. bestaande uit wonings vir die kommandant. die administrateur,. 4 getroude Iuitenante, 4 ongetroude luitenante, badka- mers, e.d.m.. 3 g. Vir die Afdeling Veldtelegrafie 'n klaskamer, 'n magasyn, 'n slaapsaaI vir 15 manskappe, 2 badkamers, e.d.m.. Scientia Militaria, South African Journal of Military Studies ...

  19. Godsdiens en die pasient - hoe sien die algemene praktisyn dit?

    African Journals Online (AJOL)

    like gevalle van die volgende altematiewe geneeskundige rigtings gebruik maak: geloofsgenesing (5); akupunktuur. (6); en hipnose (5). Sewe (23%) het in die verlede pasieme na die volgende altematiewe geneeskundige rigtings verwys: geloofsgenesing (1); akupunkruur (7); hipnose (3) en toordokters (1), waarvan almal ...

  20. ruimtelike beplanning: die rol van die stads. en streeksbeplanner in ...

    African Journals Online (AJOL)

    hoedanighede, uiteindelik begrip toon vir die behoeftes van die SAW in daardie Staatsdeparte- mente, Plaaslike Besture of private praktyke waar hulle uiteindelik werk na voltooiing van hulle dienspligtydperk. Verder bring dit mee dat die. SAW se behoeftes in ag geneem word op hoe vlakke soos in beplanningsaksies in ...

  1. Demistifikasie van die metafoor “die kerk as bruid”

    African Journals Online (AJOL)

    p1243322

    5 Sep 2007 ... Met die sluiting van die verbond met Israel het Jahwe Israel uitverkies en met Israel. “getrou”. Daarom kan die ..... that aspect which figured most prominently in ancient schemes of sexual classification and moral ..... to their husbands in patriarchal society are analogous to the demands of a jealous God, but ...

  2. 'n Verkenning van die soorte vennootskappe in die Amerikaanse reg ...

    African Journals Online (AJOL)

    In die Amerikaanse literatuur word talle verwysings gevind na die vennootskap in mynbou ("mining partnership"), familievennootskap ("family partnership", vennootskap in vaste eiendom ("partnership in real estate") en vennootskap vir boerdery ("farming partnership"). Hierdie onderskeiding is primer gebaseer op die tipe ...

  3. Die Leben Einsteins eine Reise durch die Geschichte der Physik

    CERN Document Server

    Fiami

    2005-01-01

    Jeder kennt die Namen Einstein, Newton oder Galilei. aber was weiss man über sie? Hier ein Porträt Einsteins anhand von sechs Meilensteinen aus der Geschichte der Physik. Einstein tritt auf als Protagonist in verschiedenen Epochen und bei verschiedenen Entdeckungen, die die Welt verändert haben.

  4. Die 'postmoderne' stempel in die Nuwe-Testamentiese hermeneutiek

    African Journals Online (AJOL)

    georiënteerde teorie en kritiek wat volgens Moore opbou tot 'n herhaling binne. Bybelnavorsing. Dit het reeds by Immanuel Kant begin. Sedert Kant is dit proble- maties cm die objek van kennis te beskou as iets wat kennis objektief in sigself bevat. Objektiwisme is prys gegee. Dialektiek het in die plek daarvan gekom. Die.

  5. DIE PLEK VAN SANG EN MUSIEK IN DIE PROTESTANTSE ...

    African Journals Online (AJOL)

    Test

    4 vers 21 „die vader van almal wat op die siters en fluite speel” genoem. Eintlik is al hierdie oeroue gedeeltes ... en trou; en die liedere skik hulle na hierdie vorme en hierdie inhoud. Dit is veral by hierdie liedere dat ons ..... Van der Leeuw slegs 'n bladsy ver der; „Terstond na zijn binnenkomst spreekt de Dienaar het Votum .

  6. n opinie oor die behaviouristiese siening versus die fenomenologie ...

    African Journals Online (AJOL)

    verband die eksperimente van Pavlov, Thorndike,. Skinner, Tolmann en Hull.) Fenomenologie. Die fenomenologie is 'n essensie-openbarende denkrigting. Dit impliseer'n denkende soektog na dit wat 'n besondere verskynsel of werklikheid maak juis dit wat dit is en nie iets anders nie. In die fenomenologiese antropologie ...

  7. Die ontmaskering van die bose: Eksegetiese perspektiewe op ...

    African Journals Online (AJOL)

    p1243322

    7, 11, 17,. 29; 3:1, 13, 22). ..... Bauckham (1993:197-8) oor Johannes se oorname van die geboorte van Apollo en sy oorwinning oor ... die veelkantige aard van sy agonistiese teks, maar die gewelddadige Apollo mite illustreer ook in watter ...

  8. duele verse sowel as die somtotaal die leser

    African Journals Online (AJOL)

    27 Jan 2006 ... selfs 'n landkaart afgedruk) terwyl dit ter- selfdertyd ver bo die lokale uitstyg. Die digter is sterk bewus van sy omgewing, geskiedenis en tradisies, maar veral van die algemene menslike kondisie wat binne hierdie referensiekader vergestalt word. Hy gebruik 'n bekende historiese slagveld as bundeltitel (en ...

  9. Die adversatiewe stelsel van bewyslewering en die beste belang ...

    African Journals Online (AJOL)

    MJM Venter

    DIE ADVERSATIEWE STELSEL VAN BEWYSLEWERING EN DIE BESTE. BELANG VAN DIE KIND IN EGSKEIDINGSAANGELEENTHEDE: ENKELE. GEDAGTES OOR COLLABORATIVE LAW TER BESLEGTING VAN. OUERLIKE GESKILLE http://dx.doi.org/10.4314/pelj.v18i5.09. 2015 VOLUME 18 No 5. eISSN 1727-3781 ...

  10. Die naamgewing van die dorp Pierre van Ryneveld (Van ...

    African Journals Online (AJOL)

    breiding herinner die benamings Mustang-. /aan, A/timeterweg en Kompasweg aan die. SALM. Aanlekeninge. 1. Korrespondensie te vind in DGP/A16/5/5/16/20 (SAW-argief). 2. Carel Birkby, "Sir Pierre was Air Pioneer".Sundlaan, Allimelerweg en. Kompasweg aan die SALM. Aanlekeninge. 1. Korrespondensie te vind in ...

  11. Paradigmas en progressie in die teologie: *n Perspektief op die ...

    African Journals Online (AJOL)

    Die boek van Thomas Kuhn, Structures of scientific revolutions, wat in Í970 verskyn het, het 'n groot impak op beide die ... Paradigms and progress in theology. HSRC Studies in Research Methodology 6. ..... van Lakatos se benadering vir die teologie en enige poging om 'n lewensvatbare navorsingsprogram (volgens ...

  12. Ruimtelike beplanning: die rol van die stads - en streeksbeplanner ...

    African Journals Online (AJOL)

    Ruimtelike beplanning: die rol van die stads - en streeksbeplanner in die saw. R Erasmus. Abstract. Since 1978 regional and town planners are employed in the SADF on a permanent basis as well as in the capacity of national service men. These men are all academically qualified and as such satisfy a need that developed ...

  13. praktiese wenke vir die gebruik van omgewingsopvoeding in die ...

    African Journals Online (AJOL)

    Dit is nogal moeilik om n Tweedetaal Afrikaans onderwyser te wees. Eerstens gebruik die leerlinge reels uit hulle moedertaal. Tweedens het sommige leerlinge probleme met die aanleer van tale en der- dens het redelik baie leerlinge politieke redes waarom hulle nie die taal wil aanleer nie. Omgewingsopvoeding is ...

  14. Thermal Fatigue of Die-Casting Dies: An Overview

    Directory of Open Access Journals (Sweden)

    Abdulhadi Hassan A.

    2016-01-01

    Full Text Available Coupled studies by experimental and numerical simulations are necessary for an increased understanding of the material behaviour as related to the interaction between the thermal and mechanical conditions. This paper focus on the mechanisms of thermal fatigue in the failure of dies and cores used in the die casting of aluminum alloys. The thermal fatigue resistance is expressed by two crack parameters which are the average maximum crack and the average cracked area. Samples of various types of H13 steel were compared with a standard H13 steel by testing under identical thermal fatigue cycles. To determine the thermal constraint developed in the sample during the test, a finite difference technique was used to obtain the temperature distribution, based on temperature measurements at the boundaries. The resulting stresses and strains were computed, and the strain calculated at the edge or weakest point of the sample was used to correlate the number of cycles to crack initiation. As the strain at the edge increased, the number of cycles to failure decreased. The influence of various factors on thermal fatigue behavior was studied including austenitizing temperature, surface condition, stress relieving, casting, vacuum melting, and resulfurization. The thermal fatigue resistance improved as the austenitizing temperature increased from 1750 to 2050ºF.

  15. Swaziland die Geologie en Geografie van Swaziland

    Directory of Open Access Journals (Sweden)

    J. J. Wessels

    1965-03-01

    Full Text Available In 1943 het die eerste werklike grootskaalse kartering van die gebied 'n aanvang geneem. En van 1949 af, met die koms van die eerste stel lugfoto’s, is hierdie tempo versnel. Die basiese opname van die gebied is dan ook in 1957 voltooi. In die eerste stadiums van kartering is die klassifikasie van die verskillende rotstopes gevolg soos wat dit deur Hall en later Van Eeden gedoen is. Soos die werk gevorder het, is veranderings ingevoer om die klassifikasie aan te pas by plaaslike omstandighede, maar nie almal hiervan het die toets van die tyd deurstaan nie.

  16. Antagonism between phytohormone signalling underlies the variation in disease susceptibility of tomato plants under elevated CO2.

    Science.gov (United States)

    Zhang, Shuai; Li, Xin; Sun, Zenghui; Shao, Shujun; Hu, Lingfei; Ye, Meng; Zhou, Yanhong; Xia, Xiaojian; Yu, Jingquan; Shi, Kai

    2015-04-01

    Increasing CO2 concentrations ([CO2]) have the potential to disrupt plant-pathogen interactions in natural and agricultural ecosystems, but the research in this area has often produced conflicting results. Variations in phytohormone salicylic acid (SA) and jasmonic acid (JA) signalling could be associated with variations in the responses of pathogens to plants grown under elevated [CO2]. In this study, interactions between tomato plants and three pathogens with different infection strategies were compared. Elevated [CO2] generally favoured SA biosynthesis and signalling but repressed the JA pathway. The exposure of plants to elevated [CO2] revealed a lower incidence and severity of disease caused by tobacco mosaic virus (TMV) and by Pseudomonas syringae, whereas plant susceptibility to necrotrophic Botrytis cinerea increased. The elevated [CO2]-induced and basal resistance to TMV and P. syringae were completely abolished in plants in which the SA signalling pathway nonexpressor of pathogenesis-related genes 1 (NPR1) had been silenced or in transgenic plants defective in SA biosynthesis. In contrast, under both ambient and elevated [CO2], the susceptibility to B. cinerea highly increased in plants in which the JA signalling pathway proteinase inhibitors (PI) gene had been silenced or in a mutant affected in JA biosynthesis. However, plants affected in SA signalling remained less susceptible to this disease. These findings highlight the modulated antagonistic relationship between SA and JA that contributes to the variation in disease susceptibility under elevated [CO2]. This information will be critical for investigating how elevated CO2 may affect plant defence and the dynamics between plants and pathogens in both agricultural and natural ecosystems. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology.

  17. Antagonism between phytohormone signalling underlies the variation in disease susceptibility of tomato plants under elevated CO2

    Science.gov (United States)

    Zhang, Shuai; Li, Xin; Sun, Zenghui; Shao, Shujun; Hu, Lingfei; Ye, Meng; Zhou, Yanhong; Xia, Xiaojian; Yu, Jingquan; Shi, Kai

    2015-01-01

    Increasing CO2 concentrations ([CO2]) have the potential to disrupt plant–pathogen interactions in natural and agricultural ecosystems, but the research in this area has often produced conflicting results. Variations in phytohormone salicylic acid (SA) and jasmonic acid (JA) signalling could be associated with variations in the responses of pathogens to plants grown under elevated [CO2]. In this study, interactions between tomato plants and three pathogens with different infection strategies were compared. Elevated [CO2] generally favoured SA biosynthesis and signalling but repressed the JA pathway. The exposure of plants to elevated [CO2] revealed a lower incidence and severity of disease caused by tobacco mosaic virus (TMV) and by Pseudomonas syringae, whereas plant susceptibility to necrotrophic Botrytis cinerea increased. The elevated [CO2]-induced and basal resistance to TMV and P. syringae were completely abolished in plants in which the SA signalling pathway nonexpressor of pathogenesis-related genes 1 (NPR1) had been silenced or in transgenic plants defective in SA biosynthesis. In contrast, under both ambient and elevated [CO2], the susceptibility to B. cinerea highly increased in plants in which the JA signalling pathway proteinase inhibitors (PI) gene had been silenced or in a mutant affected in JA biosynthesis. However, plants affected in SA signalling remained less susceptible to this disease. These findings highlight the modulated antagonistic relationship between SA and JA that contributes to the variation in disease susceptibility under elevated [CO2]. This information will be critical for investigating how elevated CO2 may affect plant defence and the dynamics between plants and pathogens in both agricultural and natural ecosystems. PMID:25657213

  18. Mechanisms underlying neurodegeneration in Huntington disease: applications to novel disease-modifying therapies.

    Science.gov (United States)

    Ross, Christopher A; Kronenbuerger, Martin; Duan, Wenzhen; Margolis, Russell L

    2017-01-01

    The CAG repeat expansion mutation that causes Huntington Disease (HD) was discovered more than 20 years ago, yet no treatment has yet been developed to stop the relentless course of the disease. Nonetheless, substantial progress has been made in understanding HD pathogenesis. We review insights that have been gleaned from HD genetics, metabolism, and pathology; HD mouse and cell models; the structure, function and post-translational modification of normal and mutant huntingtin (htt) protein; gene expression profiles in HD cells and tissue; the neurotoxicy of mutant htt RNA; and the expression of an antisense transcript from the HD locus. We conclude that rationale therapeutics for HD is within sight, though many questions remain to be answered. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Precision die design by the die expansion method

    CERN Document Server

    Ibhadode, A O Akii

    2009-01-01

    This book presents a new method for the design of the precision dies used in cold-forging, extrusion and drawing processes. The method is based upon die expansion, and attempts to provide a clear-cut theoretical basis for the selection of critical die dimensions for this group of precision dies when the tolerance on product diameter (or thickness) is specified. It also presents a procedure for selecting the minimum-production-cost die from among a set of design alternatives. The mathematical content of the book is relatively simple and will present no difficulty to those who have taken basic c

  20. Die Dokter-Pasient Rolverwantskap

    African Journals Online (AJOL)

    17 Aug 1974 ... en as sodanig 'n ral sped in die persoon se siektegedrag en uiteindelike patroon van hulpsoeke. SIEKEROL EN SOSIALISERING IN DIE. PASIENTROL ..... more cumulative, resulting in a more gradual social and professional maturation.' Vit die voorafgaande word dit duidelik dat Dewy se pragmatiese ...

  1. polisemie in die woordeboek - 'n

    African Journals Online (AJOL)

    betrekking tot van die vernaamste kenmerke van polisemiese kategoriee, nl. hulle vae interne en eksterne grense en .... wikkeling van die kognitiewe Iinguistiek ·~o sort out and compare the diverse phenomena that have been .... Op grond hiervan kom Geeraerts 0987a: 2) dan tot die slotsom dat 'n adekwate leksikografie-.

  2. Spatial statistical analysis of basal stem root disease under natural field epidemic of oil palm

    Science.gov (United States)

    Kamu, Assis; Phin, Chong Khim; Seman, Idris Abu; Wan, Hoong Hak; Mun, Ho Chong

    2015-02-01

    Oil palm or scientifically known as Elaeis guineensis Jacq. is the most important commodity crop in Malaysia and has greatly contributed to the economy growth of the country. As far as disease is concerned in the industry, Basal Stem Rot (BSR) caused by Ganoderma boninence remains the most important disease. BSR disease is the most widely studied with information available for oil palm disease in Malaysia. However, there is still limited study on the spatial as well as temporal pattern or distribution of the disease especially under natural field epidemic condition in oil palm plantation. The objective of this study is to spatially identify the pattern of BSR disease under natural field epidemic using two geospatial analytical techniques, which are quadrat analysis for the first order properties of partial pattern analysis and nearest-neighbor analysis (NNA) for the second order properties of partial pattern analysis. Two study sites were selected with different age of tree. Both sites are located in Tawau, Sabah and managed by the same company. The results showed that at least one of the point pattern analysis used which is NNA (i.e. the second order properties of partial pattern analysis) has confirmed the disease is complete spatial randomness. This suggests the spread of the disease is not from tree to tree and the age of palm does not play a significance role in determining the spatial pattern of the disease. From the spatial pattern of the disease, it would help in the disease management program and for the industry in the future. The statistical modelling is expected to help in identifying the right model to estimate the yield loss of oil palm due to BSR disease in the future.

  3. Die Abba-belewing by Jesus

    Directory of Open Access Journals (Sweden)

    L. Floor

    1976-05-01

    Full Text Available Ons belewe vandag woelige tye. Nie alleen in die politiek nie maar ook in die teologie. Verskillende rukwinde in die veld van die teologie het ons al geskok. Eers was daar die God-is-dood-teologie van Th. J. J. Altizer e.a. Daarna het soos ’n aandwindjie die teologie van die hoop gekom.

  4. KAAPSE PREDIKANTE VAN DIE SEWENTIENDE EN AGTIENDE ...

    African Journals Online (AJOL)

    Test

    Nooit of te nimmer het dit in die gedagte van die sestiende eeuse ... Daardie magtige beweging van die sestiende eeu was vir die Kerk ..... die vreemdsoortige boek van WERNER ScHMiDT-. PRETORïA, „Z)er A^u/furanie!/ Jes Deui.sc/:tHfns am des Buren- voices" wat voor die Tweede Wereldoorlog deur die Duitse gesant-.

  5. DIE SAW SE ROL IN SWA

    African Journals Online (AJOL)

    wei die verdediging van die landsgrense teen 'n vyand wat die orde, gesag, vrede, stabiliteit en welvaart in Suidwes-Afrika en die Republiek van. Suid-Afrika wil vernietig. Hierdie oorlog moet nie ge'lsoleerd gesien word nie, maar in perspektief geplaas word teen die agtergrond van 'n nag groter konflik, naamlik die van die ...

  6. DIE EKSISTENSIEFILOSOFIE VAN KARL JASPERS. ENKELE ...

    African Journals Online (AJOL)

    Test

    Kierkegaard en Nietzsche, Max Weber en Dilthey, om maar enkeles te noem, en 5.) Jaspers se persoonlike beskouing oor die roe ping en die taak van die Filosofie, sy aanvoeling van die filosofiese problematiek en sy grondhouding teenoor die eksistensiële verbonden- hede. Die woord van Fichte, naamlik dat die Filosofie ...

  7. HISTORIESE OORSIG VAN DIE ONTSTAAN EN ONTWIKKELING ...

    African Journals Online (AJOL)

    toe Orville op die 17de Desember 120 voet in 12 sekondes gevlieg het! Met :iil~ koms van die vliegtuig het die ... 2 Die ontwikkeling vall die militere lugvaart ell die ontstaan van selfstandiRe lugmagte met besondere venvysing na ..... as General der Flieger, sy tegnici e.a. te voorskyn. Goering was deur die Minister van ...

  8. Die besondere betekenis van die Psalms in die Christelike Kerk

    Directory of Open Access Journals (Sweden)

    A. C. Barnard

    2000-09-01

    Full Text Available The exceptional value of the Psalms in the Christian churchThe Psalms have a special place in the Bible as God's great prayer and hymn book. It is the work of various people, under the most representative situations, but it is also the work of the Holy Spirit. The Psalms express the lives, struggles, joy and praise of people before God with great clarity and true compassion. Their experiences of life, seen in the light of the living God, are vivid and real. The Christian Church took over the Psalms as their own, after the example of Jesus, whose life and work was seen as pictured in them. It became their prayer and hymn book - their life guide. The message of the Psalms is of such exceptional spiritual depth, expressing in great clarity every human need and emotion before God, that the Christian Church could find and understand itself in those situations and could associate itself with it.

  9. Reproduce and die! Why aging? Part II

    NARCIS (Netherlands)

    Schuiling, GA

    Whilst in part I of this diptych on aging the question why aging exists at all is discussed; this part deals with the question which mechanisms underly aging and, ultimately, dying. It appears that aging is not just an active process as such - although all kinds of internal (e.g., oxigen-free

  10. Arterial spin labelling in imaging of renal diseases and renal allograft pathology; MRT-Perfusionsmessung mit Arterial Spin Labelling. Anwendung fuer die Niere und Transplantatniere

    Energy Technology Data Exchange (ETDEWEB)

    Hueper, Katja; Gutberlet, Marcel [Medizinische Hochschule Hannover (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie; Kuehn, Bernd [Siemens AG/Siemens Healthcare GmbH, Erlangen (Germany)

    2016-06-15

    Arterial Spin Labelling (ASL) is a technique for non-invasive and contrast-free assessment of perfusion with MRI. Renal ASL allows examination of renal pathophysiology, evaluation of the course of renal disease and therapy effects by longitudinal measurements as well as characterization of renal tumors. In this article, techniques of ASL will be explained and challenges of renal ASL will be emphasized. In addition, examples for clinical application of ASL for diagnosis of renal disease and renal allograft pathology will be given.

  11. Sal die ‘ewolusie’ vanaf biologie na lewenswetenskappe ‘uitsterwing’ van die vakgebied voorkom?

    Directory of Open Access Journals (Sweden)

    Johanna G. Ferreira

    2012-03-01

    Full Text Available In hierdie artikel word die wysiging van die skoolvak van ‘biologie’ na ‘lewenswetenskappe’ bespreek, asook die gepaardgaande en verwagte implikasies van die verandering. Die vraag word gestel of die beoogde wysiging wel noemenswaardig is en of dit enigsins ‘n verskil aan die dalende belangstelling in die lewenswetenskappe op tersiêre vlak sal maak. Die wysigings in die nuwe kurrikula verhoog die relevansie van die vakinhoud vir leerders en vir die gemeenskap, maar sekere kwessies kry nie aandag nie. Voorstelle word gemaak om die kurrikulum te wysig en onderrigmetodes aan te pas om die nodige vaardighede by leerders te vestig.

  12. A prospective descriptive study of cryptococcal meningitis in HIV uninfected patients in Vietnam - high prevalence of Cryptococcus neoformans var grubii in the absence of underlying disease.

    Science.gov (United States)

    Chau, Tran Th; Mai, Nguyen H; Phu, Nguyen H; Nghia, Ho D; Chuong, Ly V; Sinh, Dinh X; Duong, Van A; Diep, Pham T; Campbell, James I; Baker, Stephen; Hien, Tran T; Lalloo, David G; Farrar, Jeremy J; Day, Jeremy N

    2010-07-09

    Most cases of cryptococcal meningitis occur in patients with HIV infection: the course and outcome of disease in the apparently immunocompetent is much more poorly understood. We describe a cohort of HIV uninfected Vietnamese patients with cryptococcal meningitis in whom underlying disease is uncommon, and relate presenting features of patients and the characteristics of the infecting species to outcome. A prospective descriptive study of HIV negative patients with cryptococcal meningitis based at the Hospital for Tropical Diseases, Ho Chi Minh City. All patients had comprehensive clinical assessment at baseline, were cared for by a dedicated study team, and were followed up for 2 years. Clinical presentation was compared by infecting isolate and outcome. 57 patients were studied. Cryptococcus neoformans var grubii molecular type VN1 caused 70% of infections; C. gattii accounted for the rest. Most patients did not have underlying disease (81%), and the rate of underlying disease did not differ by infecting species. 11 patients died while in-patients (19.3%). Independent predictors of death were age > or = 60 years and a history of convulsions (odds ratios and 95% confidence intervals 8.7 (1 - 76), and 16.1 (1.6 - 161) respectively). Residual visual impairment was common, affecting 25 of 46 survivors (54.3%). Infecting species did not influence clinical phenotype or outcome. The minimum inhibitory concentrations of flucytosine and amphotericin B were significantly higher for C. neoformans var grubii compared with C. gattii (p cryptococcal meningitis occurs predominantly in people with no clear predisposing factor and is most commonly due to C. neoformans var grubii. The rates of mortality and visual loss are high and independent of infecting species. There are detectable differences in susceptibility to commonly used antifungal drugs between species, but the clinical significance of this is not clear.

  13. A prospective descriptive study of cryptococcal meningitis in HIV uninfected patients in Vietnam - high prevalence of Cryptococcus neoformans var grubii in the absence of underlying disease

    Directory of Open Access Journals (Sweden)

    Baker Stephen

    2010-07-01

    Full Text Available Abstract Background Most cases of cryptococcal meningitis occur in patients with HIV infection: the course and outcome of disease in the apparently immunocompetent is much more poorly understood. We describe a cohort of HIV uninfected Vietnamese patients with cryptococcal meningitis in whom underlying disease is uncommon, and relate presenting features of patients and the characteristics of the infecting species to outcome. Methods A prospective descriptive study of HIV negative patients with cryptococcal meningitis based at the Hospital for Tropical Diseases, Ho Chi Minh City. All patients had comprehensive clinical assessment at baseline, were cared for by a dedicated study team, and were followed up for 2 years. Clinical presentation was compared by infecting isolate and outcome. Results 57 patients were studied. Cryptococcus neoformans var grubii molecular type VN1 caused 70% of infections; C. gattii accounted for the rest. Most patients did not have underlying disease (81%, and the rate of underlying disease did not differ by infecting species. 11 patients died while in-patients (19.3%. Independent predictors of death were age ≥ 60 years and a history of convulsions (odds ratios and 95% confidence intervals 8.7 (1 - 76, and 16.1 (1.6 - 161 respectively. Residual visual impairment was common, affecting 25 of 46 survivors (54.3%. Infecting species did not influence clinical phenotype or outcome. The minimum inhibitory concentrations of flucytosine and amphotericin B were significantly higher for C. neoformans var grubii compared with C. gattii (p Conclusion In HIV uninfected individuals in Vietnam, cryptococcal meningitis occurs predominantly in people with no clear predisposing factor and is most commonly due to C. neoformans var grubii. The rates of mortality and visual loss are high and independent of infecting species. There are detectable differences in susceptibility to commonly used antifungal drugs between species, but the clinical

  14. enkele fasette van die problematiek van die akademikus by die skryf

    African Journals Online (AJOL)

    Om verskeie redes het dit van die allergrootste belong geword dot 'n his- tories korrekte, wetenskaplike weerga- we van bogenoemde gebeure opge- teken moet word. Die sluier, in sommige gevalle am logiese redes toegepas, moes eenvoudig gelig word am gebeure wat die gewone man op stroot in Suid-Afrika dikwels ...

  15. enkele fasette van die problematiek van die akademikus by die skryf ...

    African Journals Online (AJOL)

    Van tyd tot tyd het die SAW amptelike verklarings ten opsigte van sekere gebeure in die "oorlog" uitge- reik. 'n Oningeligte akademikus moet daarvan kennis neem dot die ver- klaring heel dikwels om sekere spe- sifieke redes uitgereik is. So is verskeie transgrensoperasies voorafgegaan met. 'n sogenaamde propaganda.

  16. WA30 The dying well community charter and dying matters: a united kingdom (uk) approach to public health and dying.

    Science.gov (United States)

    Ali, Nuzhat; Chapman, Simon

    2015-04-01

    The Dying Matters Coalition, set up following the UK Government's End of Life Care Strategy in 2008, is led by the NCPC (UK umbrella organisation). Dying Matters supports changing knowledge, attitudes and behaviours towards dying, death and bereavement, and through this to make 'living and dying well' the norm. The Coalition has over 30,000 members, and encourages people to talk to friends and family about their end of life wishes, including how they would like to be cared for, where they want to die and their funeral plans. The Dying Well Community Charter is an innovative approach to community development work, working with Pathfinder areas to pilot this approach, rather than encouraging health and social care services to "do" end of life care "to" people, to encourage them to work with community leaders to make end of life care everyone's responsibility. Participants will discover what has worked in the UK, including many low resource options, and a community development approach to palliative care. We worked with 8 Pathfinder communities to ask them to pilot the Dying Well Community Charter approach. Dying Matters was the first national awareness and behaviour change campaign around death, dying and bereavement. Dying Matters has over 30,000 members. Outcome of the Charter work is unknown, but more will be known by the time of the conference. How communities can come together for better death, dying and bereavement. That death and dying are not subjects that need to be avoided, and can be engaged with for better outcomes. © 2015, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  17. Die hermeneutiek van gereformeerde kerkreg

    Directory of Open Access Journals (Sweden)

    Andries le Roux du Plooy

    2012-10-01

    Full Text Available Die artikel het op die belangrikheid en noodsaaklikheid van ‘n hermeneutiek vir die gereformeerde kerkreg gefokus. Die kerkregtelike dokument wat besonderlik ter sake was, is die kerkorde van die Gereformeerde kerke in Suid-Afrika, met sy besondere band met die Dordtse kerkorde van 1618 en 1619. Agtereenvolgens is aandag gegee aan die volgende aspekte soos (1 die eiesoortige aard van ‘n kerkorde as ‘n teologiese dokument en teks, in onderskeiding van regsdokumente; (2 die aard van die hermeneutiek van kerkreg; (3 enkele teorieë oor die interpretasie of uitleg van tekste, veral regstekste en (4 normatiewe vooronderstellings en reëls vir die interpretasie en verstaan van die teks en artikels van die kerkorde asook besluite van kerklike vergaderinge. Die gevolgtrekking was dat weinig indringende navorsing gedoen is oor die saak van hermeneutiek vir kerkreg, hoewel dit noodsaaklik is. Duidelike hermeneutiese reëls is gesuggereer en verduidelik, wat sou kon meehelp dat kerke en kerklike vergaderinge die artikels van die kerkorde asook besluite en reglemente wat daarop berus het, kan interpreteer en toepas. The hermeneutics of reformed church polity. The article focused on the importance and urgency of a design for reformed hermeneutics on church polity. The Church Order referred to in the article is the Church Order of the Reformed Churches in South Africa, which are closely related to the Church Order of Dordt of 1618 and 1619. The following aspects received attention namely (1  the unique character of a Church Order, in comparison to and distinguished from legal documents and statutes; (2 the character and nature of hermeneutics of church polity; (3 theories of interpretation in the common law tradition and their relevance to church polity and (4 normative presuppositions and marks for the interpretation and understanding of the text and articles of the Church Order, as well as the resolutions of church assemblies. It was found that

  18. The modern state of elms (Ulmus L., Ulmaceae in arboretum of Peter the Great Botanic Garden under conditions of epiphytoty of the Dutch elm disease

    Directory of Open Access Journals (Sweden)

    Firsov Gennadii

    2017-12-01

    Full Text Available The dying of elms (Ulmus L. at Peter the Great Botanic Garden of the Komarov Botanical Institute RAS in Saint-Petersburg has been observed since the beginning of the 1990’s, soon after the considerable St.-Petersburg climate warming in 1989. During the period from 1981 (the year of the last total inventory of the Botanic Garden to 2015 three hundred and eighty five trees died, were cut down and removed. They belonged to 12 Ulmus biological and cultivars species: U. laevis – 317 (11 trees are still alive, but all of them are infected, stem dried out from 25 to 70%, U. glabra – 40 (died completely in 2013; U. glabra ‘Camperdownii’ – 6 (died completely in 2014; U. minor – 6 (died completely in 2011; U. аmericana – 4 (died in 2007; U. × hollandica ‘Wredei’ – 3 (died in 2013; U. macrocarpa – 2 (died in 2006; U. pumila ‘Argenteo-variegata’ – 2 (died in 2007; U. japonica – 2 (1 tree is still alive; U. laciniata – 1 (died in 2015; U. parvifolia – 1 (3 trees are still alive; U. pumila – 1 (5 trees are still alive. The most severe dying began after abnormally warm winter 2006/07, the largest amount died in 2013. The most resistant to Dutch elm disease taxa were U. parvifolia and U. pumila. Further research is needed for other two taxa (U. × arbuscula and U. japonica. Selection of elms for resistance to Dutch elm disease seems to be possible. Frost damaging of many exotic tree species in St.-Petersburg has been considerably diminished because of climate warming during the previuos decades. However, introduction of some species is became limited by new negative factors, especially biotic ones (new plant diseases and pests. The future arboreal species assortment for parks and gardens of St.-Petersburg and surrounding settlements should be considerably revised in respect to this climate change.

  19. Die verband tussen lokus van beheer en die werks prestasie van swart bemarkers in die lewensversekeringsbedryf

    Directory of Open Access Journals (Sweden)

    E. L. Coetzer

    1997-06-01

    Full Text Available The relationship between locus of control and the work performance of black marketers in the life assurance industry. The aim of the study was to establish the relationship between locus of control and the work performance of black marketers in the life assurance industry. These constructs were selected by virtue of the lack of empirical research regarding the assumed relationship between them. The Locus of Control Scale of Schepers (1995 was used for measuring locus of control. Work performance was measured by the commission earned per month by the marketer, the number of policies generated by the marketer, as well as the percentage of lapsed policies. The relevant measurements were obtained in respect of a sample of 149 black marketing personnel. The results indicated a modest but statistically significant relationship between external locus of control and the work performance of black marketers. Opsomming Die doel van die studie was om die verband tussen lokus van beheer en die werksprestasie van swart bemarkers in die lewensversekeringsbedryf te bepaal. Hierdie konstrukte is gekies op grond van die gebrek aan empiriese navorsing rakende die veronderstelde verband tussen genoemde konstrukte. Die Lokus van Beheer-vraelys van Schepers (1995 is in die meting van lokus van beheer gebruik. Werksprestasie is aan die hand van kommissie per maand verdien, aantal polisse gegenereer deur 'n bemarker en die persentasie vervalde polisse, gemeet. Die tersaaklike metinge is verkry ten opsigte van 'n steekproef van 149 swart bemarkers. Die resultate toon 'n klein, dog statisties beduidende verband tussen eksterne lokus van beheer en die werksprestasie van swart bemarkers in die lewensversekeringsbedryf.

  20. Die dialektiek in die waardes van die 1996 Grondwet

    Directory of Open Access Journals (Sweden)

    J Swanepoel

    1998-11-01

    Constitution.The discussion is placed against the background of a so-called blank space in the 1996 Constitution. While the 1993 Constitution characterized South Africa as a "constitutional state", the 1996 does not contain such a characterization. It is argued in this paper that the process phrasing in section 1 (a ties in with a social democratic view of the state as an institution bringing about social change. The "state of affairs" phrasing of section 7(1 is, on the other hand, more in line with a liberal notion of a Rechtsstaat.The issue concerning what type of state South Africa is under the 1996 Constitution, will depend on which of the two poles in the above-mentioned dialectic the primary emphasis will be placed.Since the 1996 Constitution has been ratified by the Constitutional Court, it is regarded as extremely unlikely that the above-mentioned terminological problem will be rectified in future. Swanepoel provides a diagrammatic representation of the principle, values and objectives mentioned in the 1996 Constitution.Further research is envisaged concerning the possibility of developing a juridical model of reconciling the social-democratic and Rechtsstaat tendencies in the 1996 Constitution within the framework of a broader vision on the state’s task in bringing about justice.

  1. Milled Die Steel Surface Roughness Correlation with Steel Sheet Friction

    DEFF Research Database (Denmark)

    Berglund, J.; Brown, C.A.; Rosén, B.-G.

    2010-01-01

    This work investigates correlations between the surface topography ofmilled steel dies and friction with steel sheet. Several die surfaces were prepared by milling. Friction was measured in bending under tension testing. Linear regression coefficients (R2) between the friction and texture...

  2. Die Corpus Christianum in die Middeleeue

    Directory of Open Access Journals (Sweden)

    S. J. Botha

    1996-12-01

    Full Text Available The Corpus Christianum in the Middle Ages. The origin and development of the idea of Christianity as a single society in the Roman Empire under the leadership of the state or emperor and the Church or pope is investigated. The idea developed differently in the East and the West. In the East it developed into Caeseropapismand in the West, although linked to a notion of theocracy, it developed into eccesiocracy or papalcracy: both being caricatures.

  3. Dying hard industrial carnage in st lawrence, newfoundland

    CERN Document Server

    Leyton, Elliott

    2004-01-01

    Dying Hard: Industrial Carnage in St. Lawrence, Newfoundland is a series of first-hand accounts by miners suffering from industrial diseases contracted while working in the fluorspar mines of St. Lawrence, Newfoundland.

  4. Die vangnet van die woord: forensies-linguistiese getuienis in 'n ...

    African Journals Online (AJOL)

    Een van die redes daarvoor is waarskynlik die gepaardgaande sleurwerk verbonde aan die verwerking van die betrokke taaldata — iets wat egter deur die onlangse meteoriese vooruitgang in tegnologiese tegnieke op die agtergrond geskuif is en nuwe moontlikhede na vore laat kom het. In die lig van die kompleksiteit van ...

  5. Ursínus, die opsteller van die Heidelbergse Kategismus, Olevianus ...

    African Journals Online (AJOL)

    meerde teologie soos dit in Switserland ontstaan het. Pont (1986: 30-31) toon aan dat die leer van die verbond by die Switserse hervormers saamhang met die verskil in kerkbegrip tussen die Reformatore en die. Rooms-Katolieke Kerk. Zwingli het as eerste teoloog gewys op die verbond in sy stryd met die wederdopers.

  6. het om die Woord van God aan die gemeente te bedien. A. D. P ont ...

    African Journals Online (AJOL)

    Test

    Sizoo vertel met die vlotheid van die ervare skrywer en die ver antwoordelikheid van die wetenskaplike ... Maar in stiptelike trou aan die feitelikheid, verlaat die skrywer hom uitsluitlik op die outentieke bronne om ... de leser; in sy rykdom van gegewens en wetenskaplike betroubaarheid kan dit met vrug gelees word deur die ...

  7. Chrístologie: Die historiese Jesus en die kerugmatiese Christus by ...

    African Journals Online (AJOL)

    Rom 1:4; Fil 3:10; 1 Tess. 4:14). Schmithals verstaan die genesing van die seun as voorbeeld van wat die Christelike heilsgebeure beteken. In die heling van die sieke ontvang die sondaar heil. Die betekenis van die genesing is identies aan ...

  8. Die gebruik van metode in die filosofie, spesiaal in die reformatoriese tra­disie 1

    Directory of Open Access Journals (Sweden)

    N. T. van der Merwe

    1983-03-01

    Full Text Available Die onderw erp van my voordrag, Die gebruik van metode in die fílosofie, verg ’n paar verduidelikende opinerkings vooraf. Ek dink u verm oed alreeds dat hierdie fomulering ’n versuikerde pil is om u in so ’n mate nuuskierig te maak dat una ’n heerlike vrye filosofiese ‘onderonsie’ gedurende die teepouse darem vir ’n tw eede sessie terugkeer. Want is dit nie twee smaaklike heuningdruppels nie: filosofie en sy metode’ en ‘metode in die Reformatoriese filosofiese tradisie'?! Veral as in gedagte gehou word dat in teenstelling met wat ’n mens sou verw ag, daaroor dié onderwerp as sodanig relatief maar heel weinig geskrywe is en word, selfs as die ‘Inleidings in die Metodologie’ daarby gereken word.

  9. Die invloed van herbivorie en vuur op die oorlewing van sekere meerjarige kruide langs die Sabierivier, Kruger Nasionale Park

    Directory of Open Access Journals (Sweden)

    H. Myburgh

    2012-03-01

    Full Text Available Die groot vloede wat in die jaar 2000 in die Kruger Nasionale Park plaasgevind het, het dierivieroewerplantegroei versteur. Dit het die geleentheid gebied om heinings op te rig langsdie Sabierivier om herbivore uit sekere gebiede uit te sluit en sodoende die herstel van die rivieroewerekosisteme te monitor.

  10. Emergency Department Processes for the Evaluation and Management of Persons Under Investigation for Ebola Virus Disease.

    Science.gov (United States)

    Wadman, Michael C; Schwedhelm, Shelly S; Watson, Suzanne; Swanhorst, John; Gibbs, Shawn G; Lowe, John J; Iwen, Peter C; Hayes, A Kim; Needham, Susie; Johnson, Daniel W; Kalin, Daniel J; Zeger, Wesley G; Muelleman, Robert L

    2015-09-01

    Due to the recent Ebola virus outbreak in West Africa, patients with epidemiologic risk for Ebola virus disease and symptoms consistent with Ebola virus disease are presenting to emergency departments (EDs) and clinics in the United States. These individuals, identified as a person under investigation for Ebola virus disease, are initially screened using a molecular assay for Ebola virus. If this initial test is negative and the person under investigation has been symptomatic for Ebola virus disease or some other etiology, may require further investigation to direct appropriate therapy. ED administrators, physicians, and nurses proposed processes to provide care that is consistent with other ED patients. Biocontainment unit administrators, industrial hygienists, laboratory directors, physicians, and other medical personnel examined the ED processes and offered biocontainment unit personal protective equipment and process strategies designed to ensure safety for providers and patients. ED processes for the safe and timely evaluation and management of the person under investigation for Ebola virus disease are presented with the ultimate goals of protecting providers and ensuring a consistent level of care while confirmatory testing is pending. Copyright © 2015 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.

  11. Epidemiology of the Diseases of Wheat under Different Strategies of Supplementary Irrigation

    Directory of Open Access Journals (Sweden)

    Roberto P. Marano

    2012-01-01

    Full Text Available Wheat (Triticum aestivum L. is one of the most important and highly productive crops grown under supplementary irrigation in the central region of Santa Fe. However, its production is limited by the presence of diseases in the main stages for yield definition. The objective of this work was to assess wheat health in response to different supplementary irrigation strategies under greenhouse and field conditions. The field experiment included three treatments: dry (D, controlled deficit irrigation (CDI, and total irrigation (TI using the central pivot method. Disease incidence from stem elongation and severity in flag leaf and the leaf below the flag leaf were measured. Leaf area index (LAI, harvest index, air biomass, and yield components were determined. In greenhouse the treatments were TI and CDI, with evaluations similar to the field. The major leaf diseases observed were tan spot, leaf rust, and septoria leaf blotch. Significant differences in disease burden, LAI and yield components were observed in the different treatments. Under greenhouse conditions, only tan spot was observed. The results of this study indicated that the application of supplemental irrigation in wheat improved the yield, without increasing the incidence and severity of foliar diseases.

  12. Unraveling the mechanisms underlying postural instability in Parkinson's disease using dynamic posturography

    NARCIS (Netherlands)

    Nonnekes, J.H.; Kam, D. de; Geurts, A.C.; Weerdesteijn, V.G.M.; Bloem, B.R.

    2013-01-01

    Postural instability, one of the cardinal symptoms of Parkinson's disease (PD), has devastating consequences for affected patients. Better strategies to prevent falls are needed, but this calls for an improved understanding of the complex mechanisms underlying postural instability. We must also

  13. Worms under stress: C. elegans stress response and its relevance to complex human disease and aging

    NARCIS (Netherlands)

    Rodriguez Sanchez, M.; Snoek, L.B.; Bono, de M.; Kammenga, J.E.

    2013-01-01

    Many organisms have stress response pathways, components of which share homology with players in complex human disease pathways. Research on stress response in the nematode worm Caenorhabditis elegans has provided detailed insights into the genetic and molecular mechanisms underlying complex human

  14. Die heelal en sy onstaan (II

    Directory of Open Access Journals (Sweden)

    D. J. Van Rooy

    1952-03-01

    Full Text Available Ons kennis en wetenskap van die hemelliggame word volkome bepaal deur die lig wat ons van hulle ontvang, d.w.s. as ons die feite wat die Bybel daaromtrent meedeel, buite rekening laat.

  15. Accurate defect die placement and nuisance defect reduction for reticle die-to-die inspections

    Science.gov (United States)

    Wen, Vincent; Huang, L. R.; Lin, C. J.; Tseng, Y. N.; Huang, W. H.; Tuo, Laurent C.; Wylie, Mark; Chen, Ellison; Wang, Elvik; Glasser, Joshua; Kelkar, Amrish; Wu, David

    2015-10-01

    Die-to-die reticle inspections are among the simplest and most sensitive reticle inspections because of the use of an identical-design neighboring-die for the reference image. However, this inspection mode can have two key disadvantages: (1) The location of the defect is indeterminate because it is unclear to the inspector whether the test or reference image is defective; and (2) nuisance and false defects from mask manufacturing noise and tool optical variation can limit the usable sensitivity. The use of a new sequencing approach for a die-to-die inspection can resolve these issues without any additional scan time, without sacrifice in sensitivity requirement, and with a manageable increase in computation load. In this paper we explore another approach for die-to-die inspections using a new method of defect processing and sequencing. Utilizing die-to-die double arbitration during defect detection has been proven through extensive testing to generate accurate placement of the defect in the correct die to ensure efficient defect disposition at the AIMS step. The use of this method maintained the required inspection sensitivity for mask quality as verified with programmed-defectmask qualification and then further validated with production masks comparing the current inspection approach to the new method. Furthermore, this approach can significantly reduce the total number of defects that need to be reviewed by essentially eliminating the nuisance and false defects that can result from a die-to-die inspection. This "double-win" will significantly reduce the effort in classifying a die-to-die inspection result and will lead to improved cycle times.

  16. Fungi associated with die-back symptoms of apple and pear trees, a possible inoculum source of grapevine trunk disease pathogens

    Directory of Open Access Journals (Sweden)

    Mia CLOETE

    2011-12-01

    Full Text Available A survey was undertaken on apple and pear trees in the main pome fruit growing areas ofthe Western Cape of South Africa to determine the aetiology of trunk diseases with specific reference to pathogens known to occur on grapevine, which are frequently cultivated in close proximity of these orchards. Several fungal genera containing known trunk disease pathogens were found. Two Diplodia species, D. seriata and Diplodia sp., were isolated along with Neofusicoccum australe and N. vitifusiforme. Four Phaeoacremonium species, Phaeoacremonium aleophilum, Pm. iranianum, Pm. mortoniae and Pm. viticola, two Phomopsis species linked to clades identified in former studies as Phomopsis theicola and Phomopsis sp. 7, and Eutypa lata were found. In addition, Paraconiothyrium brasiliense, Pr. variabile and a Pyrenochaeta like species were also isolated. Diplodia seriata (56% of total isolates and Pm. aleophilum (22% were most frequently isolate. First reports from pear wood include the Phaeoacremonium spp. and Paraconiothyrium brasiliense, while new reports from apple include Pm. aleophilum, Ph. theicola, Phomopsis sp. 7, Pr. variabile and E. lata. A pathogenicity trial was undertaken to determine the role of these species on apple, pear and grapevine shoots. Neofusicoccum australe caused the longest lesions on grapevine shoots, while Pr. variabile, D. seriata, Pm. mortoniae and the Pyrenochaeta-like sp. caused lesions that were longer than non-inoculatedand non-pathogen experimental controls. On pear shoots, Diplodia sp. and N. australe caused the longest lesions,followed by D. seriata and E. lata. On apple shoots, the longest lesions were caused by N. australe and Pm. iranianum. These results demonstrate that apple and pear trees in Western Cape orchards are hosts to many known trunk pathogens along with potential new trunk disease-causing fungi.

  17. Die pastorale sielkundige as diakonale pastor

    Directory of Open Access Journals (Sweden)

    A. J. Smuts

    1985-08-01

    Full Text Available In die bedieningspatroon van die Ned. Geref. Kerk het die pastorale sielkundige die afgelope aantal jare steeds meer op die voorgrond begin tree. Hy is egter 'n problematiese figuur, wie se identiteit van meer as een kant onder bespreking is. In ander lande, selfs in die VSA waar die kerk veel gebruik maak van die sielkunde, is dit moeilik om 'n presiese parallel vir hom te vind. Sowel binne as buite die kerk word hy deur sommige bevraagteken. Daarom is dit noodsaaklik om vanuit die teologie te kyk na die werk wat hy doen.

  18. Die waarde van menswaardigheid in die bioetiek

    Directory of Open Access Journals (Sweden)

    A. L. Rheeder

    2009-07-01

    Full Text Available The worth of human dignity in bioethics Bioethicists and jurists put forward that the notion of “human dignity” adds nothing to the field of bioethics and is essentially a meaningless term. Against this presupposition the view is put forward that the notion of “human dignity” belongs to the heart of the Bible and can therefore be used as a valuable notion in bioethics. Human dignity is founded in the fact that man is created in the image of God. The fact that man is created in God’s image, and therefore has human dignity, undoubtedly has implications for bioethics. Human dignity by and towards man in bioethics has the meaning that one must strive for the healing of disease; that man must act and be treated as a psychosomatic unit; that reproduction may occur exclusively within marriage; and that all human life has to be maximally protected. Where the aforementioned does not occur, God- given human dignity is impinged upon.

  19. HISTORIESE OORSIG VAN DIE ONTSTAAN EN ONTWIKKELING ...

    African Journals Online (AJOL)

    In 1933 belas Rykskanselier. Hitler vir. Goering, Minister van Lugvaart, in die geheim met die skepping van die Luftwaffe. Die basis in Rusland is gesluit en toekomstige vlieeniers is nou in die geheim na Italie waar hulle elke aspek van moderne oorlog- voering oefen en die Blitzkrieg-gedagte, deur op ondersteuning van 'n.

  20. die reproduksiepatroon van vyf skaaprasse onder ekstensiewe ...

    African Journals Online (AJOL)

    terwyl Terrill & Stoehr (1939) vyf jaar oud en Asdell. (1946) ses jaar oud as die ouderdomme vir optimale vrug- baarheid beraam. Hugo (1955) vind dat geslagsaktiwiteit by Merino ooie teen die vyfde jaar die hoogste is, terwyl die teelseisoen die langste geduur het by 41/2 jaar oud ooie. By die Karakoel vind Nel (1950) dat ...

  1. Tendense in teologiese opieiding: Die pad vorentoe

    African Journals Online (AJOL)

    daarom ook die hoop wat hy aan die wêreld kan voorhou, by die dood verby reik nie. 'n Kerk sonder ewigheidsverwagting het aan 'n wêreld in nood niLs te bied nie as net die brood wat die ewige honger laat bly. Inheemswording van kerk en teologie beteken dan ook nie versoening tussen die Bybelse openbaring en ...

  2. EUNUG IN DIE ANTIEKE NABYE OOSTE

    African Journals Online (AJOL)

    rang. In Assiries beteken die woord “hoof-eunug”. Soos reeds vermeld (by 2), vorm die eunug 'n belangrike deel van die Assiriese burokrasie. Dokumente dui aan ... rang in die Babiloniese weermag, en so 'n amptenaar het saam met die rabsag ..... baie laat, in die inter-testamentêre periode, gebruik is vir 'n gekastreerde.

  3. Relating cause of death with place of care and healthcare costs in the last year of life for patients who died from cancer, chronic obstructive pulmonary disease, heart failure and dementia: A descriptive study using registry data.

    Science.gov (United States)

    van der Plas, Annicka Gm; Oosterveld-Vlug, Mariska G; Pasman, H Roeline W; Onwuteaka-Philipsen, Bregje D

    2017-04-01

    The four main diagnostic groups for palliative care provision are cancer, chronic obstructive pulmonary disease, heart failure and dementia. But comparisons of costs and care in the last year of life are mainly directed at cancer versus non-cancer or within cancer patients. Our aim is to compare the care and expenditures in their last year of life for Dutch patients with cancer, chronic obstructive pulmonary disease, heart failure or dementia. Data from insurance company Achmea (2009-2010) were linked to information on long-term care at home or in an institution, the National Hospital Registration and Causes of Death-Registry from Statistics Netherlands. For patients who died of cancer ( n = 8658), chronic obstructive pulmonary disease ( n = 1637), heart failure ( n = 1505) or dementia ( n = 3586), frequencies and means were calculated, Lorenz curves were drawn up and logistic regression was used to compare patients with high versus low expenditures. For decedents with cancer and chronic obstructive pulmonary disease, the highest costs were for hospital admissions. For decedents with heart failure, the highest costs were for the care home (last 360 days) and hospital admissions (last 30 days). For decedents with dementia, the highest costs were for the nursing home. Patients with dementia had the highest expenditures due to nursing home care. The number of dementia patients will double by the year 2030, resulting in even higher economic burdens than presently. Policy regarding patients with chronic conditions should be informed by research on expenditures within the context of preferences and needs of patients and carers.

  4. Neurokognitiewe integrasie en die leerproses

    Directory of Open Access Journals (Sweden)

    Du Preez, Johan J.

    1991-12-01

    Full Text Available The purpose of this article, "Neuro-cognitive integration and the learning process'; is to find principles and strategies for the development of brain potential and the optimal integration of subject matter. Eight neuro-cognitive systems are identified and their importance to the integration of subject matter is emphasized. These systems are cortical energy, coding, planning and controlling, as well as the verbal sequential, non-verbal holistic, physical-motor, social effective and the subconscious. The relevant principles and strategies can serve as basis for mainstream and special education, guidance as well as psychotherapy. Die doe! met hierdie artikel is om beginsels en strategiee te vind om breinpotensiaal te ontsluit en leerstof optimaal te integreer. Aan die hand van 'n neurokognitiewe model word 'n aantal beginsels en strategiee bespreek en die verband met die leerproses word aangetoon. Agt neurokognitiewe sisteme is gei'dentifiseer en die belangrike rot wat dit speel ten opsigte van die integrasie van leerstof word beklemtoon. Genoemde sisteme sluit die volgende in: kortikale energie, kodering, beplanning en kontrolering, asook die verbaal-sekwensiele, nieverbaal-holistiese, fisiek-motoriese, sosio-affektiewe en die subbewuste. Genoemde beginsels en strategiee kan oak dien as grondslag vir hoofstroomonderwys, spesialiseringsonderwys, voorligting sowel as psigoterapie.

  5. Variations in cardiovascular disease under-diagnosis in England: national cross-sectional spatial analysis

    Directory of Open Access Journals (Sweden)

    Walford Hannah

    2011-03-01

    Full Text Available Abstract Background There is under-diagnosis of cardiovascular disease (CVD in the English population, despite financial incentives to encourage general practices to register new cases. We compared the modelled (expected and diagnosed (observed prevalence of three cardiovascular conditions- coronary heart disease (CHD, hypertension and stroke- at local level, their geographical variation, and population and healthcare predictors which might influence diagnosis. Methods Cross-sectional observational study in all English local authorities (351 and general practices (8,372 comparing model-based expected prevalence with diagnosed prevalence on practice disease registers. Spatial analyses were used to identify geographic clusters and variation in regression relationships. Results A total of 9,682,176 patients were on practice CHD, stroke and transient ischaemic attack, and hypertension registers. There was wide spatial variation in observed: expected prevalence ratios for all three diseases, with less than five per cent of expected cases diagnosed in some areas. London and the surrounding area showed statistically significant discrepancies in observed: expected prevalence ratios, with observed prevalence much lower than the epidemiological models predicted. The addition of general practitioner supply as a variable yielded stronger regression results for all three conditions. Conclusions Despite almost universal access to free primary healthcare, there may be significant and highly variable under-diagnosis of CVD across England, which can be partially explained by persistent inequity in GP supply. Disease management studies should consider the possible impact of under-diagnosis on population health outcomes. Compared to classical regression modelling, spatial analytic techniques can provide additional information on risk factors for under-diagnosis, and can suggest where healthcare resources may be most needed.

  6. Relationship between low blood pressure and renal/cardiovascular outcomes in Japanese patients with chronic kidney disease under nephrologist care: the Gonryo study.

    Science.gov (United States)

    Yamamoto, Tae; Nakayama, Masaaki; Miyazaki, Mariko; Matsushima, Masato; Sato, Toshinobu; Taguma, Yoshio; Sato, Hiroshi; Ito, Sadayoshi

    2015-10-01

    Previous studies established a J-shaped association between blood pressure (BP) and cardiovascular disease (CVD) in chronic kidney disease (CKD), and the different clinical profiles of CVD by ethnicity. However, the adequately lower BP target remains unclear in Asian patients with CKD. This prospective observational study included 2,655 Japanese outpatients with CKD under nephrologist care who met the inclusion criteria, namely estimated glomerular filtration rate kidney disease (ESKD) that requires renal replacement therapy. During a 3.02-year median follow-up, 64 patients died, 120 developed CVEs, and 225 progressed to ESKD. In the adjusted Cox models, the risks of CVEs and all-cause mortality were higher in the patients with systolic BPs (SBPs) < 110 mmHg than in those with SBPs of 130-139 mmHg. Moreover, the risk was higher in those with diastolic BPs (DBPs) < 70 mmHg than in those with DBPs of 80-89 mmHg. Although SBPs ≥ 140 mmHg were associated with higher incidence rates of ESKD, no significant increased risk was associated with BPs < 130/80 mmHg. SBPs < 110 mmHg and DBPs < 70 mmHg were independent risk factors of CVEs and all-cause mortality. No lower BPs were observed as significant risk factors of progression to ESKD. This study suggests that the lower BP target in Asian patients with CKD should be ≥110/70 mmHg.

  7. Simulation study of the mechanisms underlying outbreaks of clinical disease caused by Actinobacillus pleuropneumoniae in finishing pigs

    NARCIS (Netherlands)

    Klinkenberg, D; Tobias, T J; Bouma, A; van Leengoed, L A M G; Stegeman, J A

    2014-01-01

    Actinobacillus pleuropneumoniae is a major cause of respiratory disease in pigs. Many farms are endemically infected without apparent disease, but occasionally severe outbreaks of pleuropneumonia occur. To prevent and control these outbreaks without antibiotics, the underlying mechanisms of these

  8. Die konteks vir die keuse van geriefsvoedsel van bepaalde ...

    African Journals Online (AJOL)

    Seugnet

    also helps to give meaning to the behaviour of peo- ple. The choice of an ecological framework as an ... The spendable income of the household is a product of the economy. The more price sensitive 'Baby ... ISSN 0378-5254 Journal of Family Ecology and Consumer Sciences, Vol 32, 2004. Die konteks vir die keuse van ...

  9. die ontstaan en ontwikkeling van die stafafdeling hoof van staf ...

    African Journals Online (AJOL)

    1 Jan 1981 ... geskei, hoewel die posbekleer nog vir meer as 'n jaar dieselfde persoon sou bly. Eers op 14 Ok- tober 1919 het Collyer opgehou om as AG te fungeer. Op 1 November 1919 is 'n afsonderlike posbekleer as AG aangestel toe It-kol W.E.C.. Tanner AG geword het. In wese het dit daarop neergekom dat die AG ...

  10. Die totstandkoming en bedrywighede van die ASAF-koor in ...

    African Journals Online (AJOL)

    Komposisies soos Elia van Mendelssohn, die Requiems van Mozart en Verdi, Beethoven se Negende Simfonie, Bach se Mattheuspassie en Händel se Messias was deel van hulle repertorium. Koorsang is ook deur Keet in ander sentrums aan die Witwatersrand aangemoedig. Danie van den Heever het Keet in 1963 as ...

  11. Die idioom van die Nederduitsch Hervormde Kerk - 'n Teologiese ...

    African Journals Online (AJOL)

    The idiom of the Nederduitsch Hervormde Kerk - A theological question. This article focuses on the theological thinking in the. Nederduitsch Hervormde Kerk. The way in which the ... theology, namely the knowledge of God and the service ..... Die Hervormde tradisie in ons land neem ai lank 'n 'derde opsie' in: aan die een ...

  12. \\'n Algoritme vir die minimum van die konkawe knapsakprobleem ...

    African Journals Online (AJOL)

    \\'n Algoritme vir die minimum van die konkawe knapsakprobleem. G Venter, JS Wolvaardt. Abstract. This paper addresses the problem of resource allocation among activities where the cost of each is described by a concave function. There is a single linear constraint (limited resource) and each activity has an upper and ...

  13. die museum se rolin die aankweek van 'n omgewingsbewustheid

    African Journals Online (AJOL)

    DIE MUSEUM SE ROLIN DIE AANKWEEK VAN 'N. OMGEWINGSBEWUSTHEID. Martie van der Merwe. THE ROLE OF MUSEUMS IN THE DEVELOPMENT OF ENVIRONMENTAL AWARENESS. The aim of this paper is to stress the importance and urgency of educating about the environment in the South African context.

  14. Die vlugtige taal van vergeet: Die metafoor by Breyten Breytenbach ...

    African Journals Online (AJOL)

    From his first book of poetry, die ysterkoei moet sweet (“the iron cow must sweat”, 1964), till his most recent one, die windvanger (“the windcatcher”, 2007), metaphor has been a central means towards the creation of meaning for Breytenbach. This article will investigate the use of metaphor particularly in this recent book.

  15. Die konteks vir die keuse van geriefsvoedsel van bepaalde ...

    African Journals Online (AJOL)

    Seugnet

    70. Die konteks vir die keuse van geriefsvoedsel van bepaalde beroepsvroue *. Martha Kok en Priscilla Botha. ABSTRACT. The purpose of this research is to understand and describe the context in which career women choose, purchase and use convenience food (CF). A person is rarely isolated from or unaffected by.

  16. Die WAT en etimologie: Word die kringloop voltooi?

    African Journals Online (AJOL)

    Abstract: The WAT and etymology: Will the cycle be completed? Afrikaans historical lexicography is a neglected discipline and to a large extent metalexicographers hold the overall-descriptive Afrikaans dictionary, Die Woordeboek van die Ajri1cJumse Taal, responsible for this state of affairs. The WAT, however, describes ...

  17. Die invloed van bytsodabehandelde ruvoer op die waterinname van ...

    African Journals Online (AJOL)

    Die invloed van bytsodabehandelde ruvoer op die waterinname van melkbokke. P.I. Wilke, A Smith, E Janovsky. Abstract. No Abstract. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers ...

  18. Bullinger en die verbond na aanleiding van die Tweede Switserse ...

    African Journals Online (AJOL)

    novum testamentum zusammengefast und durch seinen Tod vol- lendet oder ratifiziert hat ... Die botschaft der Evangelien ist es gerade, Christum leseum aliud nihil esse quam aetemi foederis aeternum obsidem atque misericordiae et veritatis Dei testem'. (Koch 1968: 399). Hiermee het duidelik geword dat Bullinger die ...

  19. Numerical optimization of die geometry in open die forging

    DEFF Research Database (Denmark)

    Christiansen, Peter; Hattel, Jesper Henri; Bay, Niels

    2013-01-01

    This paper deals with numerical optimization of open die forging of large metallic ingots made by casting implying risk of defects, e.g. central pores. Different material hardening properties and die geometries are combined in order to investigate, which geometry gives rise to maximum closure...... of a centreline hole in a single compression operation. Friction is also taken into account. The numerical analysis indicates that a lower die angle of approximately 140o results in the largest centreline hole closure for a wide range of material hardening. The value of optimum die angle is not influenced...... by friction, which was found only to change the degree of centreline porosity closure in case of small lower die angle....

  20. SUSCEPTOBILITY TO THERMAL FATIGUE OF CLOSED DIE HOT FORGING DIES

    Directory of Open Access Journals (Sweden)

    Frederico de Castro Magalhães

    2014-06-01

    Full Text Available Hot forging dies providing high productive performance reduce production costs. The lifetime of the dies is expressed by the number of forgings (production cycle produced before being rejected by the presence of a failure mechanism, associated with unacceptable dimensions and or geometry of the end product or even breakage of the dies. One of the failure mechanisms of hot forging dies is thermal fatigue, caused by cyclic heating and cooling. A subroutine, based on the work of Maim and Norstrom [1], was developed for the DEFORM 2D numerical software, using the finite element method, in order to predict die regions susceptible to thermal fatigue. The use of adequate coefficients for the description of the heat transfer phenomena allowed the validation of the proposed subroutine.

  1. Statues Also Die

    Directory of Open Access Journals (Sweden)

    Pierre-Philippe Fraiture

    2016-10-01

    Full Text Available “African thinking,” “African thought,” and “African philosophy.” These phrases are often used indiscriminately to refer to intellectual activities in and/or about Africa. This large field, which sits at the crossroads between analytic philosophy, continental thought, political philosophy and even linguistics is apparently limitless in its ability to submit the object “Africa” to a multiplicity of disciplinary approaches. This absence of limits has far-reaching historical origins. Indeed it needs to be understood as a legacy of the period leading to African independence and to the context in which African philosophy emerged not so much as a discipline as a point of departure to think colonial strictures and the constraints of colonial modes of thinking. That the first (self-appointed exponents of African philosophy were Westerners speaks volumes. Placide Tempels but also some of his predecessors such as Paul Radin (Primitive Man as Philosopher, 1927 and Vernon Brelsford (Primitive Philosophy, 1935 were the first scholars to envisage this extension of philosophy into the realm of the African “primitive.” The material explored in this article – Statues Also Die (Marker, Resnais, and Cloquet, Bantu Philosophy (Tempels, The Cultural Unity of Negro Africa (Cheikh Anta Diop, and It For Others (Duncan Campbell - resonates with this initial gesture but also with the ambition on part of African philosophers such as VY Mudimbe to challenge the limits of a discipline shaped by late colonialism and then subsequently recaptured by ethnophilosophers. Statues Also Die is thus used here as a text to appraise the limitations of African philosophy at an early stage.  The term “stage,” however, is purely arbitrary and the work of African philosophers has since the 1950s often been absorbed by an effort to retrieve African philosophizing practices before, or away from, the colonial matrix. This activity has gained momentum and has been

  2. Die hermeneuse van die Skrif met die oog op hedendaagse kerklik-etiese vraagstukke

    Directory of Open Access Journals (Sweden)

    J. C. Coetzee

    1980-05-01

    Full Text Available Daar is basiese reëls wat vir alle verklaring van boeke geld. Maar die eie aard en karakter van die Bybel bring ook hiermee dat sy verklaring ’n eie aard sal hê. Wat ’n mens van ’n bron dink, bepaal hoe jy met die bron omgaan. Geen eksegeet is onbevooroordeeld nie. ’n Mens se Skrifbeskouing bepaal ten diepste ook jou wyse van Skrifverklaring. Wie in die Bybel ’n gewoon menslike boek sien, sal dit met gewoon menslike hulpmiddels probeer verklaar.

  3. Challenges of malaria diagnosis in clinical settings and disease surveillance under reduced malaria burden in Tanzania

    Directory of Open Access Journals (Sweden)

    Donath Samuel Tarimo

    2017-01-01

    Full Text Available Febrile illnesses that are caused by malaria and other infectious diseases are a major cause of morbidity and mortality in sub-Saharan Africa. In malaria endemic countries, malaria is considered as one of the most serious febrile illnesses. Over the last two decades, major investment in malaria control has witnessed a major achievement in decline of malaria burden, however, other causes of febrile illnesses have remained prevalent. The decline in malaria burden poses challenges for the diagnosis of malaria in clinical settings, research and disease surveillance. This review highlights the challenges facing the diagnosis of malarial and nonmalarial fevers under reduced malaria burden from the perspectives of parasite diagnosis and interpretations of the diagnoses of malarial and non-malarial fevers, and the possible approaches to address the challenges for a better understanding of the dynamics of febrile illnesses under reduced malaria burden.

  4. Die Mythen von der Globalisierung

    DEFF Research Database (Denmark)

    Nell, Phillip; Schmitt, Jan; Decreton, Benoit

    2017-01-01

    Der Wissensstand über den Grad und die Art der Globalisierung ist viel niedriger als angenommen. Daraus entstehen Fehleinschätzungen.......Der Wissensstand über den Grad und die Art der Globalisierung ist viel niedriger als angenommen. Daraus entstehen Fehleinschätzungen....

  5. Die Parlamentswahlen 2008 in Malaysia

    DEFF Research Database (Denmark)

    Reher, Stefanie; Knirsch, Thomas

    2008-01-01

    Nach den Parlamentswahlen vom März 2008 in Malaysia deutet manches auf einen politischen Umbruch hin: Die regierende Barisan Nasional (BN), die sich bislang einer komfortablen Zweidrittelmehrheit von 91,4 Prozent der Sitze im Parlament des Landes erfreut hatte, rutschte auf 63,1 Prozent ab und das...

  6. In diens van die Kompanjie

    African Journals Online (AJOL)

    was ook siektes WQl Jit onvoldoende of ondoel- treffende voeding, eentonige kos en ontoerei- kende geneesmiddels voortgespruit het, terwyl behoorlike versorging dikwels ontbreek he!. Doodsoorsake tydens die seereis het voartge- vloei uit ongelukke aan boord, beperkte ruimte vir die bemanning en geringe vars lug, ...

  7. \\VAPENTUIG VAN DIE EERSTE VRYDEIDSOORLOG

    African Journals Online (AJOL)

    Illustrasie: F.V. Lategan: Die Boer se Roer, P 48. Die Westley. Richards-gewere wat in Suid- ...... Tesis),. Argief-jaarboek vir Suid-Afrikaanse. Geskiedenis, Negentiende. Jaargang, Deel 1, Parow, 1956. 4. Du Val, C.: With a Show through Southern Africa, London, 1884. 5. Ffoulkes, C.: Sword, Lance and Bayonet, London, ...

  8. DIE REG OP REGSVERTEENWOORDIGING TYDENS ...

    African Journals Online (AJOL)

    Administrator

    exclusio alterius, dat "geen regsverteenwoordiging by verrigtinge voor 'n verhooroffisier beoog word nie".20 Omdat 'n reg op regsverteenwoordiging nie uit die toepaslike statutêre bepalings. 13 Supra 238. 14 Supra 238-239. 15 Supra 255. 16 Smith v Beleggende Outoriteit van Kommandement Noord-Transvaal van die SA ...

  9. A Portable Kit for Rapid Diagnosis of Infectious Diseases under Field Conditions

    Science.gov (United States)

    1980-08-14

    counter Wallis, C. & Melnick , J. L. (1971). Enhanced detection current immunoelectrophoresis. Singapore Medical of Australia antigen in serum hepatitis...RESEARC CEWlE iir.’c.rpro~net~. P. 0. BOX 85122 ’i’J v’il bz la blact &Z SAN DIEGO, CALIFORNIA 92138 NAVAL MEDICAL RESEARCH AND) DEVELOPMENT COMMAND...DIAGNOSIS of INFECTIOUS DISEASES under FIELD CONDITIONS I / Warren R. Sanborn Head, Microbiology Branch Biological Sciences Division Naval Health

  10. n hoofstuk in die (outo)biografie van die predikant (pastor?) 1 ...

    African Journals Online (AJOL)

    biografie van die dominee (pastor?), spreek om verskeie redes boekdele. Die gebruik van die onbepaalde lidwoord is eerstens 'n bevestiging dat die artikel slegs 'n verdere bydrae (hoofstuk) tot die bestaande en steeds voortgaande gesprek (boek) oor die biografie van die dominee is (Heitink 2001). Tweedens plaas ek ...

  11. From pricing regulations of the feed-in scheme (EEG) through to financial security under the Atomic Energy Act (AtG): the German legal system for the energy sector in the context of EC legislation on state aid; Von den Verguetungspflichten des Energieeinspeisungsgesetzes bis zur Deckungsvorsorge des Atomgesetzes: die deutsche Energierechtsordnung im Koordinatensystem des Europaeischen Beihilfenrechts

    Energy Technology Data Exchange (ETDEWEB)

    Kuehling, J. [Zentrum fuer Europaeische Integrationsforschung (ZEI) an der Univ. Bonn (Germany)

    2001-07-01

    This contribution is a comprehensive analysis of EC law on state aid and resulting possible impacts on the German legal system for the energy sector. The analysis reveals that, depending on the legal interpretation of Art. 87 of the EC Treaty, further non-compliance issues such as that currently under debate in connection with German legislation supporting market penetration of electricity from renewable energy sources, may arise in the future. Further examples referred to are the German system of liability reserves for the decommissioning of nuclear power plants, and the system of third party liability for nuclear power plant operators. The author addresses various problem areas and uses characteristic examples in explaining conceivable matters of conflict. (orig./CB) [German] Der Beitrag ist eine umfassende Analyse des Europaeischen Beihilfenrechts und seiner Auswirkungen auf die deutsche Energierechtsordnung. Dabei wird deutlich, dass sich je nach Auslegung des Art. 87 EGV nicht nur im Hinblick auf die aktuelle deutsche Gesetzgebung zur Foerderung erneuerbarer Energien beihilfenrechtliche Probleme ergeben, sondern auch im Zusammenhang mit der Rueckstellungspraxis fuer die Stilllegung von Kernkraftwerken und das System der Haftpflicht von Kernkraftwerksbetreibern. Die unterschiedlichen Konfliktfelder werden an einigen markanten Beispielen aufgezeigt. (orig./CB)

  12. Assessing the impact of vaccination programmes on burden of disease: Underlying complexities and statistical methods.

    Science.gov (United States)

    Mealing, Nicole; Hayen, Andrew; Newall, Anthony T

    2016-06-08

    It is important to assess the impact a vaccination programme has on the burden of disease after it is implemented. For example, this may reveal herd immunity effects or vaccine-induced shifts in the incidence of disease or in circulating strains or serotypes of the pathogen. In this article we summarise the key features of infectious diseases that need to be considered when trying to detect any changes in the burden of diseases at a population level as a result of vaccination efforts. We outline the challenges of using routine surveillance databases to monitor infectious diseases, such as the identification of diseased cases and the availability of vaccination status for cases. We highlight the complexities in modelling the underlying patterns in infectious disease rates (e.g. presence of autocorrelation) and discuss the main statistical methods that can be used to control for periodicity (e.g. seasonality) and autocorrelation when assessing the impact of vaccination programmes on burden of disease (e.g. cosinor terms, generalised additive models, autoregressive processes and moving averages). For some analyses, there may be multiple methods that can be used, but it is important for authors to justify the method chosen and discuss any limitations. We present a case study review of the statistical methods used in the literature to assess the rotavirus vaccination programme impact in Australia. The methods used varied and included generalised linear models and descriptive statistics. Not all studies accounted for autocorrelation and seasonality, which can have a major influence on results. We recommend that future analyses consider the strength and weakness of alternative statistical methods and justify their choice. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Non-linear increase of respiratory diseases and their costs under severe air pollution.

    Science.gov (United States)

    Shen, Ying; Wu, Yiyun; Chen, Guangdi; Van Grinsven, Hans J M; Wang, Xiaofeng; Gu, Baojing; Lou, Xiaoming

    2017-05-01

    China is experiencing severe and persistent air pollution, with concentrations of fine particulate matters (PM 2.5 ) reaching unprecedentedly high levels in many cities. Quantifying the detrimental effects on health and their costs derived from high PM 2.5 levels is crucial because of the unsolved challenges to mitigate air pollution in the following decades. Using the daily monitoring data on PM 2.5 concentrations and clinic visits, we found a non-linear increase of respiratory diseases, but not for other diseases (e.g., digestive diseases) under severe air pollution. We found an increase of respiratory diseases by 1% for each 10 μg m -3 increase in PM 2.5 when the annual average daily PM 2.5 concentration was less than 50 μg m -3 ; while this ratio was doubled (around 2%) with the daily PM 2.5 concentration larger than 50 μg m -3 . Under severe air pollution (PM 2.5 concentration >150 μg m -3 ), the respiratory diseases increased by over 50% compared to that in clean days. Children are more sensitive to the severe air pollution. The increase of clinic visits, especially for adults, was observed mainly in bigger (>500 beds) hospitals. Re-allocating medical resources (e.g., doctors) from big hospitals to community hospitals can benefit the respiratory patients due to air pollution. The total medical cost of clinic visits of respiratory diseases derived from PM 2.5 pollution was estimated at 17.2-57.0 billion Yuan in 2014 in China, accounting for 0.5-1.6% of national total health expenditure. Because these medical costs only represent a small part of total health cost derived from air pollution, the reduction of associated health costs would be an important co-benefit of implementation of air pollution preventive strategies. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Montessori-skole: die ander kant

    Directory of Open Access Journals (Sweden)

    Monica Viljoen

    1995-03-01

    Full Text Available Na aanleiding van die artikel “Die invloed van die New Age-beweging op die onderwysagenda van die toekoms” deur Lien van Niekerk en Corinne Meier van die Departement Historiese Opvoedkunde van Unisa (vgl. Koers, 59 (1 1994:69-84 wil ek graag ’n ander sy van Montessori-skole onder die aandag van Koers lesers bring.

  15. Die gesprek tussen AB du Toit en EP Sanders oor Paulus en die ...

    African Journals Online (AJOL)

    Die pad vorentoe. PF Craffert. Universiteit van Suid-Afrika. Abstract. The debate between AB du Toit and EP Sanders on. Paul and Palestinian Judaism: The road ahead. The aim of the article is to analyse the underlying structure of the critical reaction of AB du Toit against. EP Sanders's Pauline interpretation. It is shown that.

  16. Study on the planning of a demonstration plant for hydrogen fuel production by electrolysis using caching in salt caverns under pressure; Studie ueber die Planung einer Demonstrationsanlage zur Wasserstoff-Kraftstoffgewinnung durch Elektrolyse mit Zwischenspeicherung in Salzkavernen unter Druck

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-02-05

    In a two year research project the long-term storage of hydrogen as energy carrier has been assessed in detail for large renewable electricity quantities in underground storage caverns in Germany. Next to a regions analysis for potential storage sites, the benchmarking against other large scale storage concepts, a comparative and perspective analysis of alkaline and PEM-electrolysers also potential business cases for Power-to-Hydrogen in the mobility sector as well as for the chemical, electricity and natural gas industry have been analysed. [German] Durch den geplanten Ausbau der Stromerzeugung aus fluktuierenden, erneuerbaren Energien in Deutschland ruecken Speichertechnologien fuer elektrische Energie immer staerker in den Fokus des industriellen und politischen Interesses. Eine vielversprechende Moeglichkeit fuer eine Langzeitspeicherung bei hohen Anteilen von Wind- und Photovoltaikanlagen sind Speichertechnologien wie die Wasserstoffspeicherung mit Hilfe von Wasserelektrolyseuren. Diese koennen erneuerbaren Strom in grossen Mengen und bei entsprechender Steuerung selektiv in Zeiten mit hohem Dargebot z.B. an Windstrom chemisch speichern. Der gespeicherte Wasserstoff kann dann entweder zu einem spaeteren Zeitpunkt wieder rueckverstromt oder direkt stofflich verwertet werden, z.B. als Kraftstoff fuer den Verkehrssektor, als chemischer Rohstoff oder fuer den Hausenergiebereich durch Einspeisung in das Erdgastransportnetz. Thema der vorliegenden Studie sind Analysen und Planungen fuer die Erprobung des Gesamtsystems ''Wasserstoff-Elektrolyse-Speicherung'' in energiewirtschaftlich relevanten Dimensionen. Dazu werden mit einem neuen Ansatz techno-oekonomische Entwicklungspfade fuer Wasserstoff-Systeme unterschiedlicher Groesse und Technologien charakterisiert und technologische Risiken bei der Realisierung dieser Systeme identifiziert und bewertet. Diese Arbeiten werden ergaenzt durch Arbeiten auf dem Gebiet der Salzkavernenspeicherung in Form

  17. a studyof faecal of faecal coliform die coliform die coliform die-off

    African Journals Online (AJOL)

    eobe

    ecommended that conditioners should be used to dewater sludge faster in order to speed-up pathogen die ... solar radiation. An understanding of the interacting characteristics of sewage sludge such as pH, pathogen die-off, temperature and moisture content is ... greenhouse which can be used to generate hot air.

  18. die impak van metodologie op die verstaan van die nuwe testament

    African Journals Online (AJOL)

    net vanself verskyn nie, maar dat dit gekoppel is aan die metode of ... beur het nie. Dunn (1997:12) het byvoorbeeld tereg kritiek uitgespreek op die soms onnodig ingewikkelde analises van Paulus se briewe: And as for some of the elaborate structures which have been ..... kai;eij" fulakh;n kai;eij" qavn aton poreuve sqai.

  19. Reformasie: John Knox, Die Skotse Calvinis*

    Directory of Open Access Journals (Sweden)

    V. E. d'Assonville

    1958-03-01

    Full Text Available As ons aan John Knox, die Skotse Hervormer, dink, dan sien ons voor ons oprys die beeld van die Ou-Testamentiese profeet wat sy stem in die woestyn verhef en gekleed gaan met ’n harige mantel en ’n leergord om sy heupe. John Knox het die byl aan die wortel van elke afgodsboom gelê. Soos ’n Luther het hy in die taal van die volk gespreek en daar was by hom geen vrees om selfs in paleise die oordeel van God oor konings aan te kondig nie.

  20. Lyme disease as an underlying cause of supraspinatus tendinopathy in an overhead athlete.

    Science.gov (United States)

    Coulon, Christian L; Landin, Dennis

    2012-05-01

    Supraspinatus tendinopathy is a common cause of shoulder pain seen in overhead athletes, but there appear to be no published cases that present Lyme disease as the underlying cause of tendinopathy. Lyme disease is diagnosed primarily by clinical signs and symptoms and then supported by laboratory tests, including enzyme-linked immunosorbant assay (ELISA) and Western blot testing. This case demonstrates the importance of a physical therapist's input and clinical role in reaching the correct diagnosis in an athlete with Lyme disease who had a diagnosis of rotator cuff impingement and tendinitis. A 34-year-old male tennis player was seen for physical therapy for right shoulder impingement and tendinitis diagnosed by an orthopedic surgeon. He was unable to participate in sporting activities due to impairments in strength and pain. Initial examination revealed distal supraspinatus impingement and tendinopathy. The patient was not progressing with commonly accepted interventions and began to have "arthritis-like" shoulder pain in the uninvolved left shoulder. Suspicious of an underlying condition, the physical therapist informed the physician of the patient's updated status and referred the patient to the physician to discuss the current symptoms in therapy. After testing, the patient was diagnosed with chronic Lyme disease and underwent antibiotic therapy. Many active patients spend time in the outdoors, increasing their risk of exposure to a vector for Borrelia burgdorferi. Physical therapists spend a larger portion of time with patients than other health care professionals and due to this extended contact and musculoskeletal knowledge are able to recognize atypical musculoskeletal disorders or musculoskeletal manifestations of unusual pathologies, including Lyme disease.

  1. GESINSPOLITIEK EN DIE OUER-KIND VERHOUDING Families can ...

    African Journals Online (AJOL)

    Administrator

    en die gereformeerde geloof die funksionering van die multikulturele gemeenskap en die besluitnemingsproses in die ouer-kind verhouding, bepaal het. Sedert die dertigerjare het die Suid-Afrikaanse regstelsel 'n dualistiese of pluralistiese karakter ontwikkel. Die rede vir die ontwikkeling hiervan was die implementering.

  2. OPMERKINGS OOR DIE MOONTLIKE HERSIENING VAN ONS ...

    African Journals Online (AJOL)

    Test

    (b) Wat is die redes waarom die Kerk so'n hersiening wenslik ag, of selfs noodsaaklik? (c) Watter weg sal die Kerk as Kerk moet volg, indien daar op hersiening besluit word ? Graag wil ek baie kortliks hierdie genoemde vrae met u behandel. II. D ie E erste V raag. Die eerste vraag is dan wat die Liturgiese Geskrifte is, ...

  3. Die kliniese kindersielkundige as diagnostikus1

    Directory of Open Access Journals (Sweden)

    D. J. W. Strümpfer

    1961-03-01

    Full Text Available Die benaming „Kliniese Kindersielkunde” is nog onbekend en gevolglik betreklik onbemind. Dit is in 1951 die eerste keer gebruik. Die werk van die Kliniese Kindersielkunde is egter so oud as die werk van die algemene Kliniese Sielkunde, waarvan die geskiedenis gewoonlik teruggevoer word tot die begin van sielkundige toetsing vroeg in die tagtigerjare. Tot ’n aansienlike mate is hierdie vroeë werk op kinders uitgevoer, bv. dié van Galton en later die van Binet en Simon. Witmer het in 1896 die eerste sielkundige kliniek geopen en het ook die term „Kliniese Sielkunde” ingevoer; die meerderheid van sy pasiënte was egter ook kinders. Tot voor die Tweede Wêreldoorlog was klinies-sielkundige werk hoofsaaklik op kinders toegespits. Sedertdien het die kliniese sielkundige tot ’n belangrike mate toegetree tot die gebied van die diagnose en terapie van psigiese afwykings by volwassenes, tot so ’n mate dat in die gedagtes en geskrifte van baie werkers die terrein van die Kliniese Sielkunde byna tot werk met volwassenes beperk word.

  4. Die ontwikkeling van 'n groeiende bevrydingsbediening: 'n ...

    African Journals Online (AJOL)

    Die gegewens dui daarop dat hierdie bediening in die meeste kerklike denominasies sowel as deur sommige medici en ander professionele verwante gesondheidsvakkundiges beoefen word. Die noodsaaklikheid daarvan om die resultaat van die ondersoek in teorievorming te benut, word aangedui. (Acta Theologica, 21 ...

  5. DIE RING In diens van onderlinge sorg

    African Journals Online (AJOL)

    die kerk waarin die sogenaamde postmoderne Christen homself tuis sal voel, word gewys op die feit dat hulle 'n wars het aan enige vorm van hiërargie of dwang van bo (Niemandt 2008:140, 160). Verhoudings, netwerke en plat strukture is binne hierdie kerkbegrip die aangewese weg. In gereformeerde denke ís die ring ...

  6. TAALGEBRUIKSNORMERING IN DIE SUID-AFRIKAANSE ...

    African Journals Online (AJOL)

    A. Wilkes t. Inleidend. Taalgebruiksnormering in die Suid-A£rikaanse Bantoetale behels hooEsaaklik twee aangeleenthede, naamlik die normering van die skryfstelsel, ofte wel die standaardisering daacvan soos dit algemeen onder Bantoetaalkundiges in hierdie land bekend staan, en die skep van nuwe terme.

  7. die suid-afrikaanse blanke jeug in die tweede vryheidsoorlog

    African Journals Online (AJOL)

    (Folo: Nas/ona/a Kultuurh/slor/ase en Ope/ugmuseum). 11. Scientia Militaria, South African Journal of Military Studies .... wens geeis waar die kinders op die grand san- der matrasse en baie min komberse moes slaap. .... ing them upon the rack, using the thumb-screw, or applying the red-hot iron to the soles of their feet, we ...

  8. Die Wissensgesellschaft und die Bildung des Subjekts - ein Widerspruch?

    OpenAIRE

    Sebastian Hacke; Stefan Welling

    2009-01-01

    Der Beitrag untersucht, inwiefern sich medienpädagogisch relevante Diskrepanzen zwischen dem Diskurs der Wissensgesellschaft und jugendlichem Medienhandeln nachzeichnen lassen. Dazu werden zunächst einige Aspekte des Konstrukts Wissensgesellschaft skizziert, das in seiner gegenwärtig populären Form ins Fahrwasser an volkswirtschaftlichen Verwertungskalkülen orientierter Denkformen geraten ist. Dies wird in Bezug auf die sich daran gekoppelte Programmatik von Kompetenz diskutiert, welche den «...

  9. Author: T Bekker DIE MOONTLIKE REGSHERVORMING VAN DIE ...

    African Journals Online (AJOL)

    RV

    So ver terug as die vroeë twintigste eeu het die Appèlhof in Cassiem v Standard. Bank of SA Ltd,1 .... 838; Capital Building Society v De Jager 1963 3 SA 381 (T); Smit v Walles 1985 2 SA 189 (T). 196-198. 18 ...... moeilik kon regverdig.97. Ons howe het tot op hede gehuiwer om 'n algemene plig van goeie trou ten aansien.

  10. Die verschiedenen Modi der Existenz

    OpenAIRE

    Souriau, Étienne

    2015-01-01

    "Wäre die Philosophie auch nur eine Stunde der Mühe wert, wenn sie uns nicht für das Leben rüstete?" Gezielten Schrittes entwirft der französische Philosoph Étienne Souriau in diesem dicht gedrängten Buch eine Grammatik der Existenz. Im Fokus steht nicht nur ihre Theorie, sondern auch die tatsächliche Ausübung der "Kunst des Existierens". Wie Gilles Deleuze und William James vertritt Souriau dabei die These eines existenziellen Pluralismus: Es gibt Phänomene, Dinge, das Virtuelle, fiktionale ...

  11. Die rol van persoonlikheidstrekke in die weerstand teen stres

    Directory of Open Access Journals (Sweden)

    Sonja V. R. van Oudtshoorn

    1988-05-01

    Full Text Available The role of personality characteristics in resistance to stress: A study was conducted to establish whether certain personality characteristics contribute to resistance to stress. Rescue brigadesmen, performing dangerous rescue operations in the goldmining industry, served as basis for the study. The sample consisted of 63 current, 56 ex- and 50 non-brigadesmen. Results indicate that brigadesmen, on the basis of their personality structure, are better equipped to cope with stress. Scores on the 16PF show that they have a lower level of interpersonal anxiety (Factor Q4 and that they are more practical (Factor I, emotionally stable (Factor C, and conscientious (Factor G. These findings support existing knowledge of the 16PF. Opsomming Ten einde vas te stel ofdaar sekere persoonlikheidstrekke bestaan wat bydra tot weerstand teen stres, is 'n studie uitgevoer met reddingspanlede, wat lewensgevaarlike reddingsdiens in die goudmynbedryf verrig, as ondersoekgroep. Die streekproefhet uit 63 huidige, 56 oud-reddingspanlede en 50 amptenare, wat nog nooit aan die span behoort het nie, bestaan. Dit blyk dat reddingspanlede, op grond van hulle persoonlikheidstruktuur, beter toegerus is om stres te hanteer. Tellings op die 16PF toon dat hulle oor 'n laervlakvan interpersoonlike angs beskik, (Faktor Q4, dat hulle meer prakties (Faktor I, emosioneel stabiel (Faktor C en konsensieus is (Faktor G. Hierdie bevindinge sluit aan by die reeds bestaande kennis oor die 16PF.

  12. Effect of Maize Hybrid and Foliar Fungicides on Yield Under Low Foliar Disease Severity Conditions.

    Science.gov (United States)

    Mallowa, Sally O; Esker, Paul D; Paul, Pierce A; Bradley, Carl A; Chapara, Venkata R; Conley, Shawn P; Robertson, Alison E

    2015-08-01

    Foliar fungicide use in the U.S. Corn Belt increased in the last decade; however, questions persist pertaining to its value and sustainability. Multistate field trials were established from 2010 to 2012 in Illinois, Iowa, Ohio, and Wisconsin to examine how hybrid and foliar fungicide influenced disease intensity and yield. The experimental design was in a split-split plot with main plots consisting of hybrids varying in resistance to gray leaf spot (caused by Cercospora zeae-maydis) and northern corn leaf blight (caused by Setosphaera turcica), subplots corresponding to four application timings of the fungicide pyraclostrobin, and sub-subplots represented by inoculations with either C. zeae-maydis, S. turcica, or both at two vegetative growth stages. Fungicide application (VT/R1) significantly reduced total disease severity relative to the control in five of eight site-years (P<0.05). Disease was reduced by approximately 30% at Wisconsin in 2011, 20% at Illinois in 2010, 29% at Iowa in 2010, and 32 and 30% at Ohio in 2010 and 2012, respectively. These disease severities ranged from 0.2 to 0.3% in Wisconsin in 2011 to 16.7 to 22.1% in Illinois in 2010. The untreated control had significantly lower yield (P<0.05) than the fungicide-treated in three site-years. Fungicide application increased the yield by approximately 6% at Ohio in 2010, 5% at Wisconsin in 2010 and 6% in 2011. Yield differences ranged from 8,403 to 8,890 kg/ha in Wisconsin 2011 to 11,362 to 11,919 kg/ha in Wisconsin 2010. Results suggest susceptibility to disease and prevailing environment are important drivers of observed differences. Yield increases as a result of the physiological benefits of plant health benefits under low disease were not consistent.

  13. Alveolar bone loss associated to periodontal disease in lead intoxicated rats under environmental hypoxia.

    Science.gov (United States)

    Terrizzi, Antonela R; Fernandez-Solari, Javier; Lee, Ching M; Bozzini, Clarisa; Mandalunis, Patricia M; Elverdin, Juan C; Conti, María Ines; Martínez, María Pilar

    2013-10-01

    Previously reported studies from this laboratory revealed that rats chronically intoxicated with lead (Pb) under hypoxic conditions (HX) impaired growth parameters and induced damages on femoral and mandibular bones predisposing to fractures. We also described periodontal inflammatory processes under such experimental conditions. Periodontitis is characterised by inflammation of supporting tissues of the teeth that result in alveolar bone loss. The existence of populations living at high altitudes and exposed to lead contamination aimed us to establish the macroscopic, biochemical and histological parameters consistent with a periodontal disease in the same rat model with or without experimental periodontitis (EP). Sixty female rats were divided into: Control; Pb (1000ppm of lead acetate in drinking water); HX (506mbar) and PbHX (both treatments simultaneously). EP was induced by placing ligatures around the molars of half of the rats during the 14 days previous to the autopsy. Hemi-mandibles were extracted to evaluate bone loss by histomorphometrical techniques. TNFα plasmatic concentration was greater (plead intoxication under hypoxic environment enhanced not only alveolar bone loss but also systemic and oral tissues inflammatory parameters, which could aggravate the physiopathological alterations produced by periodontal disease. Copyright © 2013 Elsevier Ltd. All rights reserved.

  14. A neural network underlying intentional emotional facial expression in neurodegenerative disease

    Directory of Open Access Journals (Sweden)

    Kelly A. Gola

    2017-01-01

    Full Text Available Intentional facial expression of emotion is critical to healthy social interactions. Patients with neurodegenerative disease, particularly those with right temporal or prefrontal atrophy, show dramatic socioemotional impairment. This was an exploratory study examining the neural and behavioral correlates of intentional facial expression of emotion in neurodegenerative disease patients and healthy controls. One hundred and thirty three participants (45 Alzheimer's disease, 16 behavioral variant frontotemporal dementia, 8 non-fluent primary progressive aphasia, 10 progressive supranuclear palsy, 11 right-temporal frontotemporal dementia, 9 semantic variant primary progressive aphasia patients and 34 healthy controls were video recorded while imitating static images of emotional faces and producing emotional expressions based on verbal command; the accuracy of their expression was rated by blinded raters. Participants also underwent face-to-face socioemotional testing and informants described participants' typical socioemotional behavior. Patients' performance on emotion expression tasks was correlated with gray matter volume using voxel-based morphometry (VBM across the entire sample. We found that intentional emotional imitation scores were related to fundamental socioemotional deficits; patients with known socioemotional deficits performed worse than controls on intentional emotion imitation; and intentional emotional expression predicted caregiver ratings of empathy and interpersonal warmth. Whole brain VBMs revealed a rightward cortical atrophy pattern homologous to the left lateralized speech production network was associated with intentional emotional imitation deficits. Results point to a possible neural mechanisms underlying complex socioemotional communication deficits in neurodegenerative disease patients.

  15. A neural network underlying intentional emotional facial expression in neurodegenerative disease.

    Science.gov (United States)

    Gola, Kelly A; Shany-Ur, Tal; Pressman, Peter; Sulman, Isa; Galeana, Eduardo; Paulsen, Hillary; Nguyen, Lauren; Wu, Teresa; Adhimoolam, Babu; Poorzand, Pardis; Miller, Bruce L; Rankin, Katherine P

    2017-01-01

    Intentional facial expression of emotion is critical to healthy social interactions. Patients with neurodegenerative disease, particularly those with right temporal or prefrontal atrophy, show dramatic socioemotional impairment. This was an exploratory study examining the neural and behavioral correlates of intentional facial expression of emotion in neurodegenerative disease patients and healthy controls. One hundred and thirty three participants (45 Alzheimer's disease, 16 behavioral variant frontotemporal dementia, 8 non-fluent primary progressive aphasia, 10 progressive supranuclear palsy, 11 right-temporal frontotemporal dementia, 9 semantic variant primary progressive aphasia patients and 34 healthy controls) were video recorded while imitating static images of emotional faces and producing emotional expressions based on verbal command; the accuracy of their expression was rated by blinded raters. Participants also underwent face-to-face socioemotional testing and informants described participants' typical socioemotional behavior. Patients' performance on emotion expression tasks was correlated with gray matter volume using voxel-based morphometry (VBM) across the entire sample. We found that intentional emotional imitation scores were related to fundamental socioemotional deficits; patients with known socioemotional deficits performed worse than controls on intentional emotion imitation; and intentional emotional expression predicted caregiver ratings of empathy and interpersonal warmth. Whole brain VBMs revealed a rightward cortical atrophy pattern homologous to the left lateralized speech production network was associated with intentional emotional imitation deficits. Results point to a possible neural mechanisms underlying complex socioemotional communication deficits in neurodegenerative disease patients.

  16. Turbulent dispersivity under conditions relevant to airborne disease transmission between laboratory animals

    Science.gov (United States)

    Halloran, Siobhan; Wexler, Anthony; Ristenpart, William

    2014-11-01

    Virologists and other researchers who test pathogens for airborne disease transmissibility often place a test animal downstream from an inoculated animal and later determine whether the test animal became infected. Despite the crucial role of the airflow in modulating the pathogen transmission, to date the infectious disease community has paid little attention to the effect of airspeed or turbulence intensity on the probability of transmission. Here we present measurements of the turbulent dispersivity under conditions relevant to experimental tests of airborne disease transmissibility between laboratory animals. We used time lapse photography to visualize the downstream transport and turbulent dispersion of smoke particulates released from a point source downstream of a standard axial fan, thus mimicking the release and transport of expiratory aerosols exhaled by an inoculated animal. We demonstrate that the fan speed counterintuitively has no effect on the downstream plume width, a result replicated with a variety of different fan types and configurations. The results point toward a useful simplification in modeling of airborne disease transmission via fan-generated flows.

  17. Are the educational differences in incidence of cardiovascular disease explained by underlying familial factors?

    DEFF Research Database (Denmark)

    Madsen, Mia; Andersen, Per K; Gerster, Mette

    2014-01-01

    To isolate the effect of education from the influence of potential underlying factors, we investigated the association of education with the risk of cardiovascular disease (CVD) and ischemic heart disease (IHD) using twin data to adjust for familial factors shared within twins, including genetic...... make-up and childhood environment. The study was based on data from the Danish Twin Registry linked to administrative and heath registers in Statistics Denmark. A total of 11,968 monozygotic and 20,464 dizygotic same sexed twins were followed from 1980 to 2009, including more than 8000 events of CVD....... Unpaired and intra-pair analyses were compared. In the unpaired analyses, an inverse educational gradient in CVD- and IHD risk was observed. This association was not replicated in the intra-pair analyses that control for shared familial factors exploiting that twins share their intrauterine- and childhood...

  18. Die Last mit der Lust

    Directory of Open Access Journals (Sweden)

    Lutz Sauerteig

    2004-03-01

    Full Text Available Robert Jütte legt mit Lust ohne Last eine umfassende, allgemeinverständliche und spannend zu lesende Geschichte der Empfängnisverhütung von der Antike bis in die unmittelbare Gegenwart vor.

  19. Nuwe patogene in die voedselbedryf

    Directory of Open Access Journals (Sweden)

    M. M. Ehlers

    1996-07-01

    Full Text Available ’n “Nuwe generasie” voedselpatogene het die afgelope jare hul verskyning gemaak en kan 'n ernstige gevaar vir die voedselbedryf inhou. Hierdie organismes is uiters aanpasbaar en bestaande voedselprosesseringstegnieke, veral die verkoeling van voedsel, is nie altyd volkome effektief om hul groei te voorkom nie. Clostridium botulinum tipe E, enterotoksigeniese Eschsrichia coli. Listeria monocytogenes en Aeromonas hydrophila is in staat om in voedsel by 5 °C te groei. Campylobacter jejuni en Brucella kan weer by 5 °C oorleef en 'n derde groep organismes, naamlik Salmonella, Staphylococcus aureus, Vibrio parahaemolyticus en Vibrio vulnificus kan by temperature tussen 5 °C en 12 °C groei en hul teenwoordigheid is ’n aanduiding dat die koueketting verbreek is.

  20. Videobasierte Unterrichtsbeobachtung: die Quadratur des Zirkels?

    Directory of Open Access Journals (Sweden)

    Regula Fankhauser

    2012-12-01

    Full Text Available Seit einigen Jahren wird Unterrichtsforschung vermehrt videobasiert angegangen. Die methodologische Diskussion, die die Weiterentwicklung des Instrumentariums begleitet, kreist dabei zentral um die Frage der Invasivität der Aufzeichnungstechnik und möglicher Kameraeffekte. Je nach methodologischer Ausrichtung wird diesem Problem anders begegnet: So versucht die abbildtheoretische Unterrichtsvideografie, die Invasivität zu kontrollieren. Qualitative Methoden wie die Kameraethnografie dagegen machen mögliche Kameraeffekte wie die Performanz vor der Kamera oder die Blickrichtung, die durch das Kameraauge fixiert wird, zum Ausgangspunkt neuer, ästhetischer Verfahrensweisen. Der vorliegende Artikel geht einen dritten Weg: Anhand eines Rückgriffs auf den Wissenschaftssoziologen LATOUR und anhand der methodologischen Reflexion eines forschungspraktischen Beispiels sollen grundsätzliche Probleme der Unterrichtsforschung herausgearbeitet werden, die sich mit dem Einsatz der Videografie besonders deutlich zeigen und mit der sich die Unterrichtsforschung vermehrt auseinandersetzen müsste. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1301241

  1. Die verband tussen gemeentebouprosesse en missionale ...

    African Journals Online (AJOL)

    n sinergie tussen die persoonlike getuienislewering van lidmate en die korporatiewe impak van die gemeente bestaan. 'It is therefore imperative that the impact of the local Church will not be accelerated without concentrating ...

  2. Innovate or Die.

    NARCIS (Netherlands)

    Jagersma, P.K.

    2003-01-01

    Concentrates on innovation as an under-exploited path to success in the business community, though reckons becoming innovative is not easy. Suggests innovative companies have a number of common characteristics, which are ten strategies to be implemented to create success, these are listed in full.

  3. Music and Memory in Alzheimer's Disease and The Potential Underlying Mechanisms.

    Science.gov (United States)

    Peck, Katlyn J; Girard, Todd A; Russo, Frank A; Fiocco, Alexandra J

    2016-01-01

    With population aging and a projected exponential expansion of persons diagnosed with Alzheimer's disease (AD), the development of treatment and prevention programs has become a fervent area of research and discovery. A growing body of evidence suggests that music exposure can enhance memory and emotional function in persons with AD. However, there is a paucity of research that aims to identify specific underlying neural mechanisms associated with music's beneficial effects in this particular population. As such, this paper reviews existing anecdotal and empirical evidence related to the enhancing effects of music exposure on cognitive function and further provides a discussion on the potential underlying mechanisms that may explain music's beneficial effect. Specifically, this paper will outline the potential role of the dopaminergic system, the autonomic nervous system, and the default network in explaining how music may enhance memory function in persons with AD.

  4. Laparoscopic cholecystectomy performed under regional anesthesia in patients with chronic obstructive pulmonary disease.

    Science.gov (United States)

    Gramatica, L; Brasesco, O E; Mercado Luna, A; Martinessi, V; Panebianco, G; Labaque, F; Rosin, D; Rosenthal, R J; Gramatica, L

    2002-03-01

    Laparoscopic cholecystectomy has been successfully performed using epidural anesthesia. We evaluated our experience with this surgical approach in high-risk patients. We present the results of 29 patients with gallstones who, between 1998 and 1999, underwent laparoscopic cholecystectomy with epidural anesthesia. All but 1 patient had chronic obstructive pulmonary disease. All 29 surgeries were successfully completed via laparoscopy and with the patients under epidural anesthesia. No patient required endotracheal intubation during surgery or pain medication afterward. Postoperatively, 1 patient developed a wound infection and 3 patients developed urinary retention. At last follow-up (12 months postop), all patients were in good health. In this series, laparoscopic cholecystectomy was feasible under epidural anesthesia and it eliminated the need for postoperative analgesia. We believe that this approach should be considered for patients who require biliary surgery but who are not good candidates for general anesthesia due to cardiorespiratory problems.

  5. Mikrobiologiese aktiwiteit tot voordeel van die mens

    Directory of Open Access Journals (Sweden)

    D. van Eeden

    1967-03-01

    Full Text Available Wanneer van mikroorganismes en hul aktiwiteite gepraat word, dink die meeste mense onwillekeurig in terme van siektes van mens en dier en ander skadelike invloede. Dit verbaas geensins, want dit is so dat van die mens se gevaarlikste vyande juis in die wêreld van die kleinste lewende organismes voorkom. Mikrobiologie as wetenskap het dan ook sy ontstaan gevind in die bestudering van hierdie organismes met die doel om hulle te kan beveg.

  6. Die verfehlte Sanktionspolitik des Westens gegen Simbabwe

    OpenAIRE

    Grauvogel, Julia; Soest, Christian von

    2015-01-01

    Am 20. Februar 2015 verlängerte die Europäische Union (EU) ihre Sanktionen gegen Simbabwes Machthaber Robert Mugabe und seine Frau Grace. Die Nachbarstaaten Simbabwes hatten sich schon immer gegen die westliche Sanktionspolitik gewandt. Als Reaktion auf Menschenrechtsverletzungen in Simbabwe hatten die EU, die USA und weitere westliche Staaten Anfang der 2000er Jahre Sanktionen gegen die Regierung Mugabe verhängt. Zeitweise waren mehrere Hundert Personen von Kontensperrungen und Reisebes...

  7. Die geheim van die prediking: om mondig te word | Cilliers | Acta ...

    African Journals Online (AJOL)

    Hierdie artikel gaan uit van die oortuiging dat prediking 'n spraakgebeure is waarin die stem van die prediker - simbool van sy of haar persoonlikheid en spiritualiteit - 'n belangrike rol het om te speel. Die stem van die prediker mag nie misken word in die dinamiese struktuur van kommunikasie nie, en moet inteendeel op 'n ...

  8. die kasteel••de goede hoop" (1921.1923): die verhaal van in ...

    African Journals Online (AJOL)

    3. TWEE. KOMITEE-VERGADERINGS. BESLUITE a. Doel en samestelling van die komitee. Op 12 Desember 1921 stuur die Sekretans yap Verdediging uitnodigings aan sekere amptelike instansies en ander behingstd1endes waarin hy die redes vir die wenslikheid van 'n komitee en die werksaamhede uitecnsit en die ge-.

  9. In die grot van die sibille. Juanita Louw. Kaapstad: Queillerie, 2016 ...

    African Journals Online (AJOL)

    stal van die Universiteit van Kaapstad. Variasie, afgerondheid en poëtiese eien- aarskap kenmerk die bundels ... Dit is ook die geval met Juanita. Louw se debuutbundel In die grot van die sibille wat getuig van 'n sterk .... wag in geel notaboeke en rooi ink, tussen my elmboë op die blad van my lessenaar. Dit is 'n boeiende ...

  10. DIE ONTW"IKKELING VAN DIE SOW"JET.VLOOT SEDERT 1945

    African Journals Online (AJOL)

    ring was die legging van die kiel in 1939 van die. CHAPAYEV- kruiser in die ligte klas (CL). Stalin se voorliefde was swaar kruisers5 en hy was 'n voorstander van ander swaar oorlogs- bodems (bv slagskepe). Nogtans het die rol wat die vliegdekskepe kon vul hom nie oortuig nie en het hy hulle konstruksie teengestaan6.

  11. Enkele opmerkings oor die intrinsieke waarde van die Latynse teks van Kodeks Bezae as herstelbron vir die Griekse teks van die Nuwe Testament

    Directory of Open Access Journals (Sweden)

    G. J.C. Jordaan

    1985-05-01

    Full Text Available Een van die belangrikste oud-Latynse vertalings word gevind in Kodeks Bezae, ’n vyfde-eeuse manuskrip van die vier Evangelies. Kodeks Bezae bevat ’n Griekse teks (D en ’n Latynse teks (d van die Evangelies langs mekaar, die Latynse teks in ’n lettertipe wat baie aan die Griekse majuskelskrif herinner. Wat hierdie dokument so merkwaardig maak, is die feit dat dit die enigste manuskrip is wat ’n Griekse Evangelie-teks uit die Westerse teksfamilie bevat.

  12. Die lewe van die Christen in die wêreld van sosiaal-politiese spanninge

    Directory of Open Access Journals (Sweden)

    K. S. van W. de Vries

    1978-06-01

    Full Text Available Ek het besluit om hierdie keer nie geleerd en wetenskaplik te skrywe nie maar om eenvoudig te bly, sodat die eenvoudigste onder ons ook by kan bly. Daarom praat en skryf ek soos ek dink. Dit bring ’n taal en styl na vore wat u miskien sal hinder, maar dit is my eie en ek bied dit nie vir navolging aan nie. U sal ook gou agterkom dat ek nie alles nie, inteendeel, baie min weet en die gebrek aan wysheid en kennis agter baie woorde probeer verberg - ook dit is nie navolgingswaardig nie, maar ek voel dat ek dit vandag so moet doen en daarom doen ek dit. En ek skuif my poginkie gerieflik in onder die magistrale na-klanke van die uitnemende sermoen wat u so pas gehoor het.

  13. Delayed pneumothorax after laparoscopic sigmoid colectomy in a patient without underlying lung disease

    Directory of Open Access Journals (Sweden)

    Richie K Huynh

    2014-10-01

    Full Text Available We present an unusual case of a delayed pneumothorax occurring approximately 72 h post-operatively in a patient without any underlying lung disease who had undergone laparoscopic sigmoid colon resection. The patient was in her mid-40s with a body mass index of 28.0 and had no history of smoking. Her spontaneous pneumothorax manifested without any precipitating events or complications during recovery. There was no evidence of any infectious process. There were no central line attempts and all ports were placed intra-peritoneally, and there was no evidence of any subcutaneous emphysema. One possible mechanism of injury that we propose is barotrauma from an extended period of time in Trendelenburg position. Notably, the only abnormal finding throughout the entire post-operative period preceding the delayed pneumothorax was a PO 2 desaturation the day before. This case highlights the necessity to examine and investigate any desaturation post-operatively and deliberate its possible significance. Furthermore, it demonstrates that, even during a normal recovery period for a patient without any underlying lung disease or risk factors, spontaneous pneumothorax could still develop in a delayed fashion multiple days post-operatively from a laparoscopic procedure.

  14. Die rol van die onderwys in die handhawing en uitbouing van ons volkskultuur

    Directory of Open Access Journals (Sweden)

    G.J. Jordaan

    1970-03-01

    Full Text Available Op die oog af lyk dit ’n baie maklike onderwerp, maar hoe meer 'n mens daaroor nadink hoe ingewikkelder en omvangryker word die implikasies wat verband hou. Dit is veral so omdat dit hier voor alles gaan om eerste fundamentele uitgangspunte, dit wil sê, om lewens- en wêreldbeskouing. Dit geld van albei komponente — van onderwys sowel as van kultuur.

  15. Non-random biodiversity loss underlies predictable increases in viral disease prevalence.

    Science.gov (United States)

    Lacroix, Christelle; Jolles, Anna; Seabloom, Eric W; Power, Alison G; Mitchell, Charles E; Borer, Elizabeth T

    2014-03-06

    Disease dilution (reduced disease prevalence with increasing biodiversity) has been described for many different pathogens. Although the mechanisms causing this phenomenon remain unclear, the disassembly of communities to predictable subsets of species, which can be caused by changing climate, land use or invasive species, underlies one important hypothesis. In this case, infection prevalence could reflect the competence of the remaining hosts. To test this hypothesis, we measured local host species abundance and prevalence of four generalist aphid-vectored pathogens (barley and cereal yellow dwarf viruses) in a ubiquitous annual grass host at 10 sites spanning 2000 km along the North American West Coast. In laboratory and field trials, we measured viral infection as well as aphid fecundity and feeding preference on several host species. Virus prevalence increased as local host richness declined. Community disassembly was non-random: ubiquitous hosts dominating species-poor assemblages were among the most competent for vector production and virus transmission. This suggests that non-random biodiversity loss led to increased virus prevalence. Because diversity loss is occurring globally in response to anthropogenic changes, such work can inform medical, agricultural and veterinary disease research by providing insights into the dynamics of pathogens nested within a complex web of environmental forces.

  16. Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease

    DEFF Research Database (Denmark)

    Baillie, J Kenneth; Bretherick, Andrew; Haley, Christopher S

    2018-01-01

    Genetic variants underlying complex traits, including disease susceptibility, are enriched within the transcriptional regulatory elements, promoters and enhancers. There is emerging evidence that regulatory elements associated with particular traits or diseases share similar patterns...... the regulation of the OCT1 cation transporter and genetic variants underlying circulating cholesterol levels. NDA strongly implicates particular cell types and tissues in disease pathogenesis. For example, distinct groupings of disease-associated regulatory regions implicate two distinct biological processes...... in the pathogenesis of ulcerative colitis; a further two separate processes are implicated in Crohn's disease. Thus, our functional analysis of genetic predisposition to disease defines new distinct disease endotypes. We predict that patients with a preponderance of susceptibility variants in each group are likely...

  17. Transcriptomic Analysis and the Expression of Disease-Resistant Genes in Oryza meyeriana under Native Condition.

    Directory of Open Access Journals (Sweden)

    Bin He

    Full Text Available Oryza meyeriana (O. meyeriana, with a GG genome type (2n = 24, accumulated plentiful excellent characteristics with respect to resistance to many diseases such as rice shade and blast, even immunity to bacterial blight. It is very important to know if the diseases-resistant genes exist and express in this wild rice under native conditions. However, limited genomic or transcriptomic data of O. meyeriana are currently available. In this study, we present the first comprehensive characterization of the O. meyeriana transcriptome using RNA-seq and obtained 185,323 contigs with an average length of 1,692 bp and an N50 of 2,391 bp. Through differential expression analysis, it was found that there were most tissue-specifically expressed genes in roots, and next to stems and leaves. By similarity search against protein databases, 146,450 had at least a significant alignment to existed gene models. Comparison with the Oryza sativa (japonica-type Nipponbare and indica-type 93-11 genomes revealed that 13% of the O. meyeriana contigs had not been detected in O. sativa. Many diseases-resistant genes, such as bacterial blight resistant, blast resistant, rust resistant, fusarium resistant, cyst nematode resistant and downy mildew gene, were mined from the transcriptomic database. There are two kinds of rice bacterial blight-resistant genes (Xa1 and Xa26 differentially or specifically expressed in O. meyeriana. The 4 Xa1 contigs were all only expressed in root, while three of Xa26 contigs have the highest expression level in leaves, two of Xa26 contigs have the highest expression profile in stems and one of Xa26 contigs was expressed dominantly in roots. The transcriptomic database of O. meyeriana has been constructed and many diseases-resistant genes were found to express under native condition, which provides a foundation for future discovery of a number of novel genes and provides a basis for studying the molecular mechanisms associated with disease

  18. as by die huisbesoek. HP WOLMARANS. PROF. DR. SP ...

    African Journals Online (AJOL)

    Test

    van 'n evangeüedienaar wat alles fei! gehad het vir die werk en werk kring waartoe God hom geroep het. Hy is dan ook werklik die eerste grondlegger van die gemeente in Zoutpansberg en die man wat dit opgewerk het. Die geskiedenis van Hofmeyer is die geskiedenis van die kerk- vereniging en die redes waarom die ...

  19. Die krisis van ongeloof in Numeri 13-14

    African Journals Online (AJOL)

    Die ver- haal gebruik die aanloklikheid van die land as 'n submotief om 'n groter drama uit te beeld: die konflik tussen Israel en sy God. ISSN 0259 9422 ... In aansluiting by Eksodus 34 laat die liefde en trou van die Here aan Horn die ...... langs die weg van die tema van veertig jaar dat 'de hoofdstukken 13-14 een sleutel-.

  20. Die vraag na ’n nuwe belydenisskrif

    Directory of Open Access Journals (Sweden)

    J. H. van Wyk

    1974-05-01

    Full Text Available Die mees bekende reformatoriese belydenisskrifte dateer uit die sestiende en sewentiende eeue (E 16—17 en is dus almal 300 tot 400 jaar oud: Die Galliese Konfessie 1559, die Nederlandse Geloofsbelydenis 1561, die Heidelbergse Kategismus 1563, die 39 Articles 1563, die Tweede Helvietiese Konfessie 1566, die Dordtse Leerreëls 1619, die Westminsterse Konfessie 1646.

  1. Live and let die

    DEFF Research Database (Denmark)

    Næss, Petter

    2004-01-01

    , increased consumption in wealthy countries will reduce the possibility of meeting the needs of a growing population in developing countries within the limits set by the Earth`s ecological carrying capacity. Today, the willingness among the decision makers in rich countries to pursue a sustainable......Under a paradigm of unlimited natural resources and recipient capacity for emissions, raising the material standard of the world`s poor did not seem to be seriously in conflict with increasing consumption levels in affluent nations, even with a growing global population. In a finite world...

  2. Verslag van die tweede internasionale calvynkongres

    Directory of Open Access Journals (Sweden)

    Editorial Office

    1978-06-01

    Full Text Available Dr. B. J. v.d. Walt het die kongres aan die Vrije Universiteit, Amsterdam, 25 — 28 September 1978, bygewoon en doen daarvan soos volg verslag: Eintlik was hierdie die eerste internasionale Calvynkongres. Die Calvynkongres wat vanaf 16 — 19 September 1974 aan die Vrije Universiteit gehou is,was ’n Europese kongres. Hierdie tweede byeenkoms het nie alleen meer navorsers getrek nie (ongeveer 80 teenoor die 40 Calvynkenners by die eerste byeenkoms, maar die kongresgangers het ook veel meer lande (16 verteenwoordig — selfs van so vêr as die VSA, Kanada, Japan, Korea en Suid-Afrika. Ook lande agter die ystergordyn soos die Deutsche Demokratische Republik, Hongarye en Roemenië was goed verteenwoordig.

  3. [How Johannes Brahms died].

    Science.gov (United States)

    Kerner, D

    1979-04-20

    In 1896, when he was 63 years old, Johannes Brahms, who had always been demonstrably in good health, developed an icterus of increasing intensity together with a considerable enlargement of the liver and loss of weight. Since infectious hepatitis could scarcely come into the question, from the medical point of view a neoplasm in the region of the liver as well as cirrhosis of the liver were considered. While hepatic carcinoma is a relatively rare disease in Europe even today and Brahms, on the other hand, had consumed copious quantities of concentrated alcoholic drinks during his lifetime, cirrhosis of the liver is the most probable diagnosis, especially as at the end hemorrhages from esophageal varices and the lower intestinal segments occurred.

  4. Totius en die boek Openbaring

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    H.A. Louw

    1999-08-01

    Full Text Available Totius and the Book of Revelation In his sermons on the book Revelation, published in 1921, the Afrikaans theologian and poet, Prof. J.D. du Toit, better known under the pseudonym Totius, took the “futurist” view as the principal way to explain this Bible book. Elements of other views like the “historicist view” were also followed, especially in the sermon on the seven churches in Asia Minor, which regarded each church as concerned with later periods in the history of Western Europe. According to Du Toit the scene of the sealing of the servants of God (7:1-8 and of the great multitude mentioned later in the chapter (7:9-17 is set at the end of time. It should, however, be better to interpret chapter 7:1-8 as the church in John's time and the vast crowd of people from every nation as an image of the redeemed in the bliss of heaven. The multitude who comes (present tense out of the great tribulation are those who died for their faith when Revelation was written. But the article describing the multitude in the original Greek text also seems to indicate the great trouble accompanying the end of things. For Du Toit the prostitute in chapter 17 symbolizes a city, namely Babylon. The harlot, however, had slain a great number of saints who believed in Jesus (17:6. Thus the harlot cannot be identified with Babylon. The city must be Rome, the contemporary representative of the cruel empires which, through the ages have enslaved people by brute force. Rome also killed saints who served Christ. Du Toit’s greatest shortcoming in his explanation of the Book of Revelation was that he did not see that the book Revelation is rooted in a given historical situation.

  5. Chagas disease: national survey of seroprevalence in children under five years of age conducted in 2008

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    Graciela Russomando

    Full Text Available BACKGROUND Since the early 1990s, programs to control Chagas disease in South America have focused on eradicating domiciliary Triatoma infestans, the main vector. Seroprevalence studies of the chagasic infection are included as part of the vector control programs; they are essential to assess the impact of vector control measures and to monitor the prevention of vector transmission. OBJECTIVE To assess the interruption of domiciliary vector transmission of Chagas disease by T. infestans in Paraguay by evaluating the current state of transmission in rural areas. METHODS A survey of seroprevalence of Chagas disease was carried out in a representative sample group of Paraguayans aged one to five years living in rural areas of Paraguay in 2008. Blood samples collected on filter paper from 12,776 children were tested using an enzyme-linked immunosorbent assay. Children whose serology was positive or undetermined (n = 41 were recalled to donate a whole blood sample for retesting. Their homes were inspected for current triatomine infestation. Blood samples from their respective mothers were also collected and tested to check possible transmission of the disease by a congenital route. FINDINGS A seroprevalence rate of 0.24% for Trypanosoma cruzi infection was detected in children under five years of age among the country’s rural population. Our findings indicate that T. cruzi was transmitted to these children vertically. The total number of infected children, aged one to five years living in these departments, was estimated at 1,691 cases with an annual incidence of congenital transmission of 338 cases per year. MAIN CONCLUSION We determined the impact of vector control in the transmission of T. cruzi, following uninterrupted vector control measures employed since 1999 in contiguous T. infestans-endemic areas of Paraguay, and this allowed us to estimate the degree of risk of congenital transmission in the country.

  6. Chagas disease: national survey of seroprevalence in children under five years of age conducted in 2008.

    Science.gov (United States)

    Russomando, Graciela; Cousiño, Blanca; Sanchez, Zunilda; Franco, Laura X; Nara, Eva M; Chena, Lilian; Martínez, Magaly; Galeano, María E; Benitez, Lucio

    2017-05-01

    Since the early 1990s, programs to control Chagas disease in South America have focused on eradicating domiciliary Triatoma infestans, the main vector. Seroprevalence studies of the chagasic infection are included as part of the vector control programs; they are essential to assess the impact of vector control measures and to monitor the prevention of vector transmission. To assess the interruption of domiciliary vector transmission of Chagas disease by T. infestans in Paraguay by evaluating the current state of transmission in rural areas. A survey of seroprevalence of Chagas disease was carried out in a representative sample group of Paraguayans aged one to five years living in rural areas of Paraguay in 2008. Blood samples collected on filter paper from 12,776 children were tested using an enzyme-linked immunosorbent assay. Children whose serology was positive or undetermined (n = 41) were recalled to donate a whole blood sample for retesting. Their homes were inspected for current triatomine infestation. Blood samples from their respective mothers were also collected and tested to check possible transmission of the disease by a congenital route. A seroprevalence rate of 0.24% for Trypanosoma cruzi infection was detected in children under five years of age among the country's rural population. Our findings indicate that T. cruzi was transmitted to these children vertically. The total number of infected children, aged one to five years living in these departments, was estimated at 1,691 cases with an annual incidence of congenital transmission of 338 cases per year. We determined the impact of vector control in the transmission of T. cruzi, following uninterrupted vector control measures employed since 1999 in contiguous T. infestans-endemic areas of Paraguay, and this allowed us to estimate the degree of risk of congenital transmission in the country.

  7. Chagas disease: national survey of seroprevalence in children under five years of age conducted in 2008

    Science.gov (United States)

    Russomando, Graciela; Cousiño, Blanca; Sanchez, Zunilda; Franco, Laura X; Nara, Eva M; Chena, Lilian; Martínez, Magaly; Galeano, María E; Benitez, Lucio

    2017-01-01

    BACKGROUND Since the early 1990s, programs to control Chagas disease in South America have focused on eradicating domiciliary Triatoma infestans, the main vector. Seroprevalence studies of the chagasic infection are included as part of the vector control programs; they are essential to assess the impact of vector control measures and to monitor the prevention of vector transmission. OBJECTIVE To assess the interruption of domiciliary vector transmission of Chagas disease by T. infestans in Paraguay by evaluating the current state of transmission in rural areas. METHODS A survey of seroprevalence of Chagas disease was carried out in a representative sample group of Paraguayans aged one to five years living in rural areas of Paraguay in 2008. Blood samples collected on filter paper from 12,776 children were tested using an enzyme-linked immunosorbent assay. Children whose serology was positive or undetermined (n = 41) were recalled to donate a whole blood sample for retesting. Their homes were inspected for current triatomine infestation. Blood samples from their respective mothers were also collected and tested to check possible transmission of the disease by a congenital route. FINDINGS A seroprevalence rate of 0.24% for Trypanosoma cruzi infection was detected in children under five years of age among the country’s rural population. Our findings indicate that T. cruzi was transmitted to these children vertically. The total number of infected children, aged one to five years living in these departments, was estimated at 1,691 cases with an annual incidence of congenital transmission of 338 cases per year. MAIN CONCLUSION We determined the impact of vector control in the transmission of T. cruzi, following uninterrupted vector control measures employed since 1999 in contiguous T. infestans-endemic areas of Paraguay, and this allowed us to estimate the degree of risk of congenital transmission in the country. PMID:28443980

  8. Ortopedie in die Grieks - Romeinse era

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    Louise Cilliers

    2009-09-01

    Full Text Available Die gevorderde hantering van afwykings van bene en gewrigte, Ortopedie, het in Mesopotamië en veral in antieke Egipte sy ontstaan gehad. Dit was egter die Griekse geneeshere wat in die laat 5de eeu v.C. in die Hippokratiese Korpus ’n merkwaardig doeltreffende samevatting van die ortopediese beroep vasgelê het, waarop vir minstens ’n 1 000 jaar nie beduidend verbeter sou word nie. Gebaseer op die onderskeiding tussen toe en oop frakture en ontwrigtings (lg. met oorliggende velwond, en aansienlik swakker prognose is hierdie afwykings so spoedig moontlik gereduseer (selfs deur middel van meganiese tegnieke, die oorliggende vel met seraatsalf gesmeer en dan met kompresse en verbande geïmmobiliseer. Gedurende die eerste 12 dae is die letsel herhaaldelik weer oopgemaak om die fraktuur of ontwrigting te herbelyn indien nodig. Eers hierna is ferm immobilisasie met onder andere spalke aangebring. Beduidende druk op die letsel is vermy omdat daar geglo is dat dit sepsis en gangreen aanbring. Dit is aanvaar dat genesing 20 dae (by byvoorbeeld voet-, rib- en sleutelbeenfrakture en 40 dae (by been- en bo-armfrakture sou duur. Benewens algemeen geldende prosedures is die spesifi  eke hantering van 18 verskillende frakture en ’n groot aantal ontwrigtings in besonderhede uitgespel. Oor ander ortopediese afwykings soos degeneratiewe artritis en jig verskyn daar min in die Hippokratiese werke, maar later geneeshere in die Romeinse era (bv. Celsus, Soranus, Aretaeus en Galenus het dit wel beskryf. Daar is aanduiding dat die hantering van siektes van gewrigte en bene by die mens (die dissipline van ortopedie in moderne terminologie reeds in antieke Egipte deeglik bestudeer en aangeteken is. 1 Tydens die klassieke era en die Romeinse tyd is beduidende verdere bydraes gelewer. In hierdie studie word die ewolusionêre ontwikkeling van ortopedie as kliniese studierigting in die antieke tyd, onder die loep geneem.

  9. Exploring the Contemporary Stage and Scripts for the Enactment of Dying Roles: A Narrative Review of the Literature.

    Science.gov (United States)

    Lowrie, Daniel; Ray, Robin; Plummer, David; Yau, Matthew

    2018-03-01

    This narrative review explores the literature regarding the drama of dying from several academic perspectives. Three key themes were identified including "The impact of blurred boundaries on roles and transitions," "The orchestration of death and dying through time," and "Contemporary dying and new machinery of control." This review reveals the manner in which tightly scripted dying roles serve the needs of the living to a greater extent than those of the dying, by ensuring the depiction of both dying and death as phenomena which have been brought under the control of the living, thereby countering death anxiety. An incongruence between the actual experience of dying and contemporary dying scripts is also highlighted. The authors argue that this incongruence is hidden from the broader societal audience through the maintenance of a dying role that demands serenity and acceptance, thus downplaying or even hiding the actual end-of-life experiences of the dying themselves.

  10. Die atmosfeer in die erediens deur die loop van die geskiedenis

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    BJ de Klerk

    2007-09-01

    Full Text Available The worship service occupies a central position in the life of the believer and therefore the atmosphere in the worship service is vital. The variations through history are studied in this article.� The viewpoints of the first four centuries, the Middle Ages, Reformation, post-Reformation and twentieth century came under discussion. Lessons from history are stated. The atmosphere in the worship service should be such that the worshipper meets God with the necessary awe and respect.� The service must also create an atmosphere of love, warmth, friendliness, and joy. All present must be invited and made welcome by the service. The atmosphere must further encourage and create room for everybody to participate and use their specific gifts. It can therefore change from service to service and within a single service. Important instruments in the atmosphere are the liturgical space, symbols, rituals, physical movement, gestures, music, song and the senses.

  11. Died of wounds: a mortality review.

    Science.gov (United States)

    Keene, Damian Douglas; Penn-Barwell, J G; Wood, P R; Hunt, N; Delaney, R; Clasper, J; Russell, R J; Mahoney, P F

    2016-10-01

    Combat casualty care is a complex system involving multiple clinicians, medical interventions and casualty transfers. Improving the performance of this system requires examination of potential weaknesses. This study reviewed the cause and timing of death of casualties deemed to have died from their injuries after arriving at a medical treatment facility during the recent conflicts in Iraq and Afghanistan, in order to identify potential areas for improving outcomes. This was a retrospective review of all casualties who reached medical treatment facilities alive, but subsequently died from injuries sustained during combat operations in Afghanistan and Iraq. It included all deaths from start to completion of combat operations. The UK military joint theatre trauma registry was used to identify cases, and further data were collected from clinical notes, postmortem records and coroner's reports. There were 71 combat-related fatalities who survived to a medical treatment facility; 17 (24%) in Iraq and 54 (76%) in Afghanistan. Thirty eight (54%) died within the first 24 h. Thirty-three (47%) casualties died from isolated head injuries, a further 13 (18%) had unsurvivable head injuries but not in isolation. Haemorrhage following severe lower limb trauma, often in conjunction with abdominal and pelvic injuries, was the cause of a further 15 (21%) deaths. Severe head injury was the most common cause of death. Irrespective of available medical treatment, none of this group had salvageable injuries. Future emphasis should be placed in preventative strategies to protect the head against battlefield trauma. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  12. Structural and Mechanical Properties of Intermediate Filaments under Extreme Conditions and Disease

    Science.gov (United States)

    Qin, Zhao

    Intermediate filaments are one of the three major components of the cytoskeleton in eukaryotic cells. It was discovered during the recent decades that intermediate filament proteins play key roles to reinforce cells subjected to large-deformation as well as participate in signal transduction. However, it is still poorly understood how the nanoscopic structure, as well as the biochemical properties of these protein molecules contribute to their biomechanical functions. In this research we investigate the material function of intermediate filaments under various extreme mechanical conditions as well as disease states. We use a full atomistic model and study its response to mechanical stresses. Learning from the mechanical response obtained from atomistic simulations, we build mesoscopic models following the finer-trains-coarser principles. By using this multiple-scale model, we present a detailed analysis of the mechanical properties and associated deformation mechanisms of intermediate filament network. We reveal the mechanism of a transition from alpha-helices to beta-sheets with subsequent intermolecular sliding under mechanical force, which has been inferred previously from experimental results. This nanoscale mechanism results in a characteristic nonlinear force-extension curve, which leads to a delocalization of mechanical energy and prevents catastrophic fracture. This explains how intermediate filament can withstand extreme mechanical deformation of > 1 00% strain despite the presence of structural defects. We combine computational and experimental techniques to investigate the molecular mechanism of Hutchinson-Gilford progeria syndrome, a premature aging disease. We find that the mutated lamin tail .domain is more compact and stable than the normal one. This altered structure and stability may enhance the association of intermediate filaments with the nuclear membrane, providing a molecular mechanism of the disease. We study the nuclear membrane association

  13. Potential distribution of pine wilt disease under future climate change scenarios.

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    Akiko Hirata

    Full Text Available Pine wilt disease (PWD constitutes a serious threat to pine forests. Since development depends on temperature and drought, there is a concern that future climate change could lead to the spread of PWD infections. We evaluated the risk of PWD in 21 susceptible Pinus species on a global scale. The MB index, which represents the sum of the difference between the mean monthly temperature and 15 when the mean monthly temperatures exceeds 15°C, was used to determine current and future regions vulnerable to PWD (MB ≥ 22. For future climate conditions, we compared the difference in PWD risks among four different representative concentration pathways (RCPs 2.6, 4.5, 6.0, and 8.5 and two time periods (2050s and 2070s. We also evaluated the impact of climate change on habitat suitability for each Pinus species using species distribution models. The findings were then integrated and the potential risk of PWD spread under climate change was discussed. Within the natural Pinus distribution area, southern parts of North America, Europe, and Asia were categorized as vulnerable regions (MB ≥ 22; 16% of the total Pinus distribution area. Representative provinces in which PWD has been reported at least once overlapped with the vulnerable regions. All RCP scenarios showed expansion of vulnerable regions in northern parts of Europe, Asia, and North America under future climate conditions. By the 2070s, under RCP 8.5, an estimated increase in the area of vulnerable regions to approximately 50% of the total Pinus distribution area was revealed. In addition, the habitat conditions of a large portion of the Pinus distribution areas in Europe and Asia were deemed unsuitable by the 2070s under RCP 8.5. Approximately 40% of these regions overlapped with regions deemed vulnerable to PWD, suggesting that Pinus forests in these areas are at risk of serious damage due to habitat shifts and spread of PWD.

  14. Potential distribution of pine wilt disease under future climate change scenarios.

    Science.gov (United States)

    Hirata, Akiko; Nakamura, Katsunori; Nakao, Katsuhiro; Kominami, Yuji; Tanaka, Nobuyuki; Ohashi, Haruka; Takano, Kohei Takenaka; Takeuchi, Wataru; Matsui, Tetsuya

    2017-01-01

    Pine wilt disease (PWD) constitutes a serious threat to pine forests. Since development depends on temperature and drought, there is a concern that future climate change could lead to the spread of PWD infections. We evaluated the risk of PWD in 21 susceptible Pinus species on a global scale. The MB index, which represents the sum of the difference between the mean monthly temperature and 15 when the mean monthly temperatures exceeds 15°C, was used to determine current and future regions vulnerable to PWD (MB ≥ 22). For future climate conditions, we compared the difference in PWD risks among four different representative concentration pathways (RCPs 2.6, 4.5, 6.0, and 8.5) and two time periods (2050s and 2070s). We also evaluated the impact of climate change on habitat suitability for each Pinus species using species distribution models. The findings were then integrated and the potential risk of PWD spread under climate change was discussed. Within the natural Pinus distribution area, southern parts of North America, Europe, and Asia were categorized as vulnerable regions (MB ≥ 22; 16% of the total Pinus distribution area). Representative provinces in which PWD has been reported at least once overlapped with the vulnerable regions. All RCP scenarios showed expansion of vulnerable regions in northern parts of Europe, Asia, and North America under future climate conditions. By the 2070s, under RCP 8.5, an estimated increase in the area of vulnerable regions to approximately 50% of the total Pinus distribution area was revealed. In addition, the habitat conditions of a large portion of the Pinus distribution areas in Europe and Asia were deemed unsuitable by the 2070s under RCP 8.5. Approximately 40% of these regions overlapped with regions deemed vulnerable to PWD, suggesting that Pinus forests in these areas are at risk of serious damage due to habitat shifts and spread of PWD.

  15. Die invloed van die Tweede Vryheidsoorlog (1899-1902 op die Teologiese Skool Burgersdorp

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    P. Krüger

    2000-08-01

    Full Text Available The influence of the Second War of Independence (1899-1902 on the Theological Seminary of Burgersdorp In this article the reasons for the War are pinpointed as England’s imperialism and the underlying motif of getting hold of the riches and gold of the ZAR. At the outbreak of the War the students and lecturers of the Burgersdorp Theological Seminary, as most Boers in the Cape Colony, had to make a decisive choice: loyalty to the Government of the Cape Colony or to their fellow kinsmen in the North (and thus siding with the latter. Varying facets of the war-torn situation are touched upon in this article: the lecturers were for example accused of treason but acquitted. The outcome of the 30 students’ situation, however, differed. Those students origally from the northern Republics returned home to join their commandos. Some of these students were taken prisoners of war. Most of the Cape students showed their solidarity with their northern compatriots by joining the Ambulance Corps. Three students and two former students eventually died (one was the son of Prof. Lion Cachet. In honour of these students a monument was erected in 1906. Only one student and three former students were rebels, as far as is presently known. At a later stage three students were able to continue their studies in the Netherlands. Two of these, J.D. du Toit and F. Postma, later returned to South Africa and committed their lives to the Theological Seminary at Potchefstroom and the Potchefstroom University for CHE.

  16. Der Nahostkonflikt und die Medien

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    Carola Richter

    2014-06-01

    Full Text Available Diese Einführung in eine Themenausgabe zu den vielfältigen Rollen der Medien im Nahostkonflikt skizziert die Probleme, die sich für Medien und Journalisten als Akteure im Konflikt, Adressaten der Konfliktparteien und Anlass für Konflikt durch ihre Berichterstattung ergeben. Das Konfliktgebiet Israel und Palästina ist sowohl für Forschung über Auslandsbericht-erstattung, über transnationale Agenda Building- und Public Diplomacy-Prozesse als auch über mediensystemische Entwicklungen in Besatzer- und Besatzungsgebieten interessant. Der Artikel gibt einen Überblick über das Feld und führt dabei in die in der Themenausgabe präsentierten empirischen Studien zum Nahostkonflikt und den Medien ein.

  17. Die resepsie van die Heidelbergse Kategismus (Sondag 17 en 22 insake die opstanding in die Nederduitse Gereformeerde Kerk sedert 2000 (Deel 2

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    Johannes W. Hofmeyr

    2013-08-01

    Full Text Available Met die 450e herdenking van die Heidelbergse Kategismus as vertrekpunt, word met die huidige en die vorige artikel gepoog om lig te werp op die plek, die rol en die interpretasie van die opstanding van Jesus Christus in veral Sondag 17 en 22, spesifiek in die konteks van twee besondere eras in die Nederduitse Gereformeerde (NG Kerk. In die vorige artikel is allereers ’n bespreking gevoer oor die Heidelbergse Kategismus (HK. Daar is gekyk na die resepsie van die betrokke HK-geloofsartikels in die era van Andrew Murray, spesifiek teen die agtergrond van die negentiende-eeuse liberale teologie in Nederland. In die huidige artikel word soortgelyk gekyk na die resepsie van die betrokke HK-geloofsartikels in die NG Kerk na 2000, teen die agtergrond van die herverskyning van die negentiende-eeuse liberale teologie in die vorm van die Jesus Seminaar, die Nuwe Hervorming en ondersteuners daarvan binne die NG Kerk. Sowel die negentiende-eeuse liberale stryd in die NG Kerk asook die stryd oor die opstanding in die NG Kerk van die eerste dekade van die een-en-twintigste eeu, soos verder in hierdie artikel sal blyk, was gekenmerk deur kontekstueelbepaalde uniekhede. Die gemene deler was dat albei deel was van tye van teologiese vrysinnigheid. In die lig van hierdie bespreking word tot die gevolgtrekking gekom dat die NG Kerk tans, betreffende haar identiteit as gereformeerde kerk waarskynlik in ’n kritieke geloofs- en toekomskrisis verkeer. Dit impliseer kommerwekkende gevolge vir haar Skrifverstaan en getuienis as belydenis en belydende kerk van Jesus Christus en haar toekoms. Alleen duidelike visie, verantwoordelike leierskap en ’n herontdekking van die verlossingskrag van Christus se kruis en opstanding sal herstellende, positiewe en dinamiese oplossings kan bied om sodoende die NG Kerk te red van ’n snelwentelende afwaartse spiraal. With the 450th celebrations of the origin of the Heidelberg Catechism (HC in mind, the main aim of this and the

  18. Die Gereformeerde Ekumeniese Sinode en Sending 1984

    African Journals Online (AJOL)

    opvatting. Indien 'n mens al die kerke wat aan die Gereformeerde. Ekumeniese Sinode (GES) behoort een vir een sendingmatig sal be- studeer, sal daar waarskynlik 'n sterk differensiasie tussen sommige kerke aan die lig kom. Die GES kan dus nie verantwoordelik gehou word vir individuele kerke se sendingopvatting nie.

  19. Die verhouding Bybelse teologie en dogmatiese teologie

    African Journals Online (AJOL)

    verhouding met dogmatiese teologie moet wees. 1. WAT IS BYBELSE TEOLOGIE? Wanneer 'n mens die geskiedenis van Bybelse teologie nagaan en kennis neem van hoe dit in die laaste paar dekades bedryf is, word dit gou duidelik dat die begrip Bybelse teologie nie so vanselfsprekend en eenduidig is as wat dit op die ...

  20. Moderne diskoerse in die teologie vandag

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    J.H. van Wyk

    2013-05-01

    Full Text Available In hierdie artikel word aandag gevra vir enkele moderne diskoerse in die teologie vandag. Volgens die outeur staan die vrae oor God, Jesus, die mens en die aarde in die sentrum van belangstelling en oorheers dit in ’n groot mate die teologiese debat. Die opkoms van die moderne aggressiewe ateïsme, die wetenskaplike navorsing oor die historiese Jesus, die groeiende vrae oor die mens en die menslike samelewing, asook die dreigende ekologiese krisis op aarde, sorg vir nuwe debatte van ongekende omvang. Die outeur bespreek hierdie debatte oorsigtelik, met kritiek waar nodig, en sluit af met enkele rigtingwysers van wat hy as ‘goeie teologie’ verstaan. In this article attention is paid to some modern discourses in theology today. According to the author the questions about God, Jesus, man and the earth are in the centre of interest and to a large extent dominate the theological debate. The rise of modern aggressive atheism, the scientific research on the historic Jesus, the growing questions about man and human society as well as the threatening ecological crisis on earth, provide new discourses of unparalleled magnitude. The author provides a broad summary of these discourses, with criticism where necessary, and concludes with some indicators of his view what can be called ‘good theology’.

  1. voorgeskiedenis tot die stigting van 'n unieverdedigingsmag

    African Journals Online (AJOL)

    gesien nie en toe die wetsontwerp op 23 Februa- rie 1912 deur Smuts in sy hoedanigheid as Mi- nister van Verdediging ingedien is, het Beyers heelwat kritiek daarop gehad. Beyers het be- weer dat dit op vergaderings geblyk het dat die volk wou he Engeland moet steeds die verdedi- ging waarneem aangesien die Unie ...

  2. NUWE ONTWIKKELING OP DIE TERREIN VAN ...

    African Journals Online (AJOL)

    onderhoud (Holter, Heald & Colovos, 1970). maar dit kon tot dusver nie bevestig word in die geval van weefselsintese uit asynsuur nie (sien Thomas & Rook,. 1973). Daar bestaan egter min twyfel dat die verhou- ding van vlugtige vetsuurproduksie wel in sommige ge- valle die doeltreffende benutting van die vetsure deur.

  3. strategiese bakens vir die wisselwerking tussen eenheid ...

    African Journals Online (AJOL)

    Liezel

    INLEIDING. Vanuit die gereformeerde tradisie word vrae gestel oor die effektiwiteit van die kerk in 'n snel veranderende samelewing en veelbesproke postmoderne kon- teks (Vorster 1996:23). Hiermee saam dwing die dalende lidmaatgetalle van. Ds. G. van Wyk, Skool vir Kerkwetenskappe, Fakulteit Teologie, Noordwes-.

  4. DIE VRYWILLIGERSMAGTE VAN GRIEKWALAND-WES

    African Journals Online (AJOL)

    teen gekant was, is dit op 15 Oktober 1880 by die Kaapkolonie ingelyf.9. Gedurende sy kortstondige bestaan van minder as 'n dekade lank het die kroonkolonie Griekwa- land-Wes met talle finansiele, ekonomiese, so- siale en ander probleme te doen gehad. Een van die ernstige probleme was die bedreiging wat.

  5. Normatiwiteit versus neutraliteit in die tegniese wetenskappe

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    L. Alberts

    1974-03-01

    Full Text Available Die essens van hierdie referaat is nie ’n pleidooi vir ’n normatiewe benadering tot beoefening van die wetenskap op natuurkundige terrein nie, maar eerder 'n aanvaarding van die onvermydelikheid daarvan en ’n poging om dan die konsekwensies in oënskou te neem.

  6. Oor die Nuwe Testament, vertelkunde en prediking

    African Journals Online (AJOL)

    Maar die omstandighede was anders as in Palestina waar Jesus in. Galilea buite die groot stad en onder die landelike bevolking opgetree het. Dit was ook moeilik om as Christen in 'n oorheersend heidense stad jou oortuigings van Jesus die opgestane Heer uit te leef. Dink maar aan Efese! Kan 'n mens jou voorstel hoe ...

  7. Die Hervormde Teologiese Studies na vyftig jaar

    African Journals Online (AJOL)

    of Scholarly Literature, die Université LavaJ in Québec, Kanada se Bibliographical. Information Bank in Patristics, die Catholic University of America in Washington,. DC se Old Testament Abstracts, die Weston School of Theology in Cambridge, MA se New Testament Abstracts en die Religious and Theological Abstracts wat ...

  8. Geskiedenis van die Geneeskunde in Pretoria*

    African Journals Online (AJOL)

    31 Jul 1971 ... Elandspoort het aan Andries van der WaIt behoort en. Daspoort aan Joggem Tweeduim Prinsloo. ... Van der Hoff en die Vierkleur, ook deur horn ontwerp, word vir die eerste keer gehys. Die eerste ... met net 'n ketting van 50 voet, en 'n verkyker tot sy beskikking. Al die strate was 80 voet breed behalwe ...

  9. Leerteoretiese basis van die andragogie

    Directory of Open Access Journals (Sweden)

    C. J. A. Simpson

    1991-06-01

    Full Text Available Learning theory basis of andragogy. A cursory glance at andragogy creates the impression that humanistic learning theory plays an all encompassing role in the learner centered approach andragogy espouses. A closer look, however, reveals that Knowles (1973, after having made an intensive study of learning theory, created an extensive framework within which human resource development can take place. The fact that Knowles attracted critique from different areas, led to a need to ascertain the role different learning theories, if any, played in the emergence of andragogy. Having looked at the assumptions displayed by the andragogical approach, as well as a comparison of different learning theories and their connection with andragogy, it became clear that andragogy contains elements of various learning theories in an adapted way. These adaptations resulted in an approach to adult education in which learners are given the opportunity to be part of the learning process in such a way that they themselves contribute to the development which takes place. Opsomming Met 'n eerste oogopslag wil dit voorkom asof humanistiese leerteorie 'n oorheersende rol in die leerdergesentreerde benadering van andragogie speel. By nadere ondersoek blyk dit egter dat Knowles (1973, na 'n deeglike studie van verskillende leerteoretiese beginsels, 'n omvangryke raamwerk geskep het waarbinne, aan die hand van verskeie aangepaste leerteoretiese beginsels, menslike hulpbronontwikkeling kan plaasvind. As gevolg van die feit dat Knowles vanuit verskillende oorde kritiek op die lyf geloop het, is besluit om die rol wat verskillende leerteorieë in andragogie speel, te bestudeer. Dit blyk dat andragogie nie net elemente van verskillende leerteorieë bevat nie, maar dat toepaslike aspekte van die teoriee wat ondersoek is, benut en aangepas is om 'n geintegreerde benadering te bewerkstellig waarin veral volwassene-leerders by leergeleenthede en hulle selfontwikkeling betrek word.

  10. The Mechanisms of Traditional Chinese Medicine Underlying the Prevention and Treatment of Parkinson's Disease

    Directory of Open Access Journals (Sweden)

    Xiaoliang Li

    2017-09-01

    Full Text Available Parkinson's disease (PD, characterized with bradykinesia, static tremor, rigidity and disturbances in balance, is the second most common neurodegenerative disorder. Along with the largely aging population in the world, the incidence is increasing year by year, which imposes the negative impacts on patients, their families and the whole society. Traditional Chinese medicine (TCM has a positive prospect for the prevention and cure of PD due to its advantages of less side effects and multi-target effects. At present, the pathogenesis of PD is not yet fully discovered. This paper elaborates the mechanisms of TCM underlying the prevention and treatment of PD with regards to the inhibition of oxidative stress, the regulation of mitochondrial dysfunction, the reduction of toxic excitatory amino acids (EAA, the inhibition of neuroinflammation, the inhibition of neuronal apoptosis, and the inhibition of abnormal protein aggregation.

  11. Resistance Potential of Bread Wheat Genotypes Against Yellow Rust Disease Under Egyptian Climate.

    Science.gov (United States)

    Mahmoud, Amer F; Hassan, Mohamed I; Amein, Karam A

    2015-12-01

    Yellow rust (stripe rust), caused by Puccinia striiformis f. sp. tritici, is one of the most destructive foliar diseases of wheat in Egypt and worldwide. In order to identify wheat genotypes resistant to yellow rust and develop molecular markers associated with the resistance, fifty F8 recombinant inbred lines (RILs) derived from a cross between resistant and susceptible bread wheat landraces were obtained. Artificial infection of Puccinia striiformis was performed under greenhouse conditions during two growing seasons and relative resistance index (RRI) was calculated. Two Egyptian bread wheat cultivars i.e. Giza-168 (resistant) and Sakha-69 (susceptible) were also evaluated. RRI values of two-year trial showed that 10 RILs responded with RRI value >6 2 rust. However, further molecular analyses would be performed to confirm markers associated with the resistance and suitable for marker-assisted selection. Resistant RILs identified in the study could be efficiently used to improve the resistance to yellow rust in wheat.

  12. Exploring the genetics underlying autoimmune diseases with network analysis and link prediction

    KAUST Repository

    Alanis Lobato, Gregorio

    2014-02-01

    Ever since the first Genome Wide Association Study (GWAS) was carried out we have seen an important number of discoveries of biological and clinical relevance. However, there are some scientists that consider that these research outcomes and their utility are far from what was expected from this experimental design. We instead believe that the thousands of genetic variants associated with complex disorders by means of GWASs are an extremely valuable source of information that needs to be mined in a different way. Based on this philosophy, we followed a holistic perspective to analyze GWAS data and explored the structural properties of the network representation of one of these datasets with the aim to advance our understanding of the genetic intricacies underlying autoimmune human diseases. The simplicity, computational efficiency and precision of the tools proposed in this paper represent a new means to address GWAS data and contribute to the better exploitation of these rich sources of information. © 2014 IEEE.

  13. PS Dreyer: Bakens op die pad van die wetenskap

    African Journals Online (AJOL)

    standing of Greek philosophy should be of significance for time to come. Two milestones could be distinguished: ... of the knowledge of values in ethics by valuation in contradistinction to knowledge through feeling, reason ..... Aristoteles (384-322 v C), in Faure, AM et al (red) 1981, Die West erse politieke tradisie. Pretoria: ...

  14. Die ontwikkeling van menslike potensiaal in die Republiek van Suid ...

    African Journals Online (AJOL)

    Erna Kinsey

    Dit het dus ook te doen met lewenstandaard, aangesien lewenstandaard `n bepalende faktor is met betrekking tot die optimale ontwikkeling van menslike potensiaal. Ander minder materiële aspekte van menslike potensiaal het te doen met menslike vryheid, waaronder vryheid van spraak, beweging en keuse ter sake is.

  15. Method of treating tool steel die materials

    International Nuclear Information System (INIS)

    Cook, C.S.; Damon, S.

    1981-01-01

    In a method of hardening pilger dies to provide a hard case containing residual compressive stresses and tough body, the tool steel die is heated to the austenitizing temperature range, followed by selectively removing heat from the die at a predetermined faster rate in the direction of the desired case than the rate of heat removal from the balance of the die, and thereafter tempering the die. The invention provides a fully hardened and tempered case on the working surface of the die and a tough body in the balance of the die, usually of lower hardness. (author)

  16. Die «ASEAN-Wirtschaftsgemeinschaft»

    DEFF Research Database (Denmark)

    Juego, Bonn

    2014-01-01

    Seit dem Ende der 1990er-Jahre verfolgt die ASEAN die Vision einer politischen, wirtschaftlichen und sozialen Gemeinschaft. Doch wie realistisch ist die Umsetzung eines solch ambitionierten Vorhabens vor dem Hintergrund der enormen Heterogenität der Region? ASEAN vereint Staaten auf...... Entwicklungsstufen, wie sie unterschiedlicher kaum sein können. Der Autor, Bonn Juego, nimmt die ASEAN Vision 2020 sowie die Debatten, die diesbezüglich in den einzelnen Ländern geführt werden, unter die Lupe. Er geht dem Potenzial des ASEANAnsatzes zu sozialer Teilhabe und wirtschaftlicher Verteilungsgerechtigkeit...

  17. Parkinson disease

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000755.htm Parkinson disease To use the sharing features on this page, please enable JavaScript. Parkinson disease results from certain brain cells dying. These cells ...

  18. Portable punch and die jig

    Science.gov (United States)

    Lewandowski, Edward F.; Anderson, Petrus A.

    1978-01-01

    A portable punch and die jig includes a U-shaped jig of predetermined width having a slot of predetermined width in the base thereof extending completely across the width of the jig adapted to fit over the walls of rectangular tubes and a punch and die assembly disposed in a hole extending through the base of the jig communicating with the slot in the base of the jig for punching a hole in the walls of the rectangular tubes at precisely determined locations.

  19. [Dying with cancer: Hollywood lessons].

    Science.gov (United States)

    Niemeyer, Fernanda; Kruse, Maria Henriqueta Luce

    2013-12-01

    The study attempts to understand how dying from cancer is portrayed by five movies produced in Hollywood between 1993 and 2006. Based on the cultural studies and their post-structuralism version and supported by the notions of discourse and subjectivity, as proposed by philosopher Michel Foucault, we suggest one of the possible readings of the movie picture corpus. We assess how the movie picture discourse acts as a cultural pedagogy that produces ways of seeing dying with cancer: immortalizing the healthy body image, silencing death, taking care of the dead body and, finally, accepting death. Our proposal is intended to stimulate reflections that may contribute to care and education in nursing.

  20. Die Herz-Lungen-Maschine

    Science.gov (United States)

    Krane, Markus; Bauernschmitt, Robert; Lange, Rüdiger

    Das Kapitel der modernen Herzchirurgie mit Einsatz der Herz-Lungen-Maschine am Menschen beginnt am 6. Mai 1953, als J. Gibbon bei einer 18-jährigen Patientin einen angeborenen Defekt in der Vorhofscheidewand verschließt [1]. Mit ersten experimentellen Versuchen zur extrakorporalen Zirkulation begann Gibbon bereits in den 30er Jahren des 20. Jahrhunderts. Die Grundlage für die heute gebräuchliche Rollerpumpe schufen Porter und Bradley mit ihrer "rotary pump“, welche sie 1855 zum Patent anmeldeten. Diese Pumpe wurde von DeBakey und Schmidt modifiziert und entspricht im Wesentlichen noch der heute sich im Routinebetrieb befindlichen Rollerpumpe [2].

  1. Existential Needs among the Dying

    DEFF Research Database (Denmark)

    Moestrup, Lene

    meaning making. Methods: The key research question is: 1. What kind of existential needs are central to dying cancer patients and their relatives during the terminal phase in Danish hospices? Exploring this highly sensitive and complex research area entails substantial ethical responsibility during data...... based and practice relevant knowledge about the complexity of existential considerations and needs among dying cancer patients and their relatives in a secularized society as Denmark. Existential needs are seen as a multidimensional concept that encompasses religious, spiritual and secular existential...

  2. Underlying mechanism of antimicrobial activity of chitosan microparticles and implications for the treatment of infectious diseases.

    Directory of Open Access Journals (Sweden)

    Soo Jin Jeon

    Full Text Available The emergence of antibiotic resistant microorganisms is a great public health concern and has triggered an urgent need to develop alternative antibiotics. Chitosan microparticles (CM, derived from chitosan, have been shown to reduce E. coli O157:H7 shedding in a cattle model, indicating potential use as an alternative antimicrobial agent. However, the underlying mechanism of CM on reducing the shedding of this pathogen remains unclear. To understand the mode of action, we studied molecular mechanisms of antimicrobial activity of CM using in vitro and in vivo methods. We report that CM are an effective bactericidal agent with capability to disrupt cell membranes. Binding assays and genetic studies with an ompA mutant strain demonstrated that outer membrane protein OmpA of E. coli O157:H7 is critical for CM binding, and this binding activity is coupled with a bactericidal effect of CM. This activity was also demonstrated in an animal model using cows with uterine diseases. CM treatment effectively reduced shedding of intrauterine pathogenic E. coli (IUPEC in the uterus compared to antibiotic treatment. Since Shiga-toxins encoded in the genome of bacteriophage is often overexpressed during antibiotic treatment, antibiotic therapy is generally not recommended because of high risk of hemolytic uremic syndrome. However, CM treatment did not induce bacteriophage or Shiga-toxins in E. coli O157:H7; suggesting that CM can be a potential candidate to treat infections caused by this pathogen. This work establishes an underlying mechanism whereby CM exert antimicrobial activity in vitro and in vivo, providing significant insight for the treatment of diseases caused by a broad spectrum of pathogens including antibiotic resistant microorganisms.

  3. Hygiene and sanitation risk factors of diarrhoeal disease among under-five children in Ibadan, Nigeria.

    Science.gov (United States)

    Oloruntoba, Elizabeth Omoladun; Folarin, Taiwo Bukola; Ayede, Adejumoke Idowu

    2014-12-01

    Diarrhoea diseases are among the leading causes of morbidity and mortality in under-five-children (U-5C) in Nigeria. Inadequate safe water, sanitation, and hygiene account for the disease burden. Cases of diarrhoea still occur in high proportion in the study area despite government-oriented interventions. To determine the hygiene and sanitation risk factors predisposing U-5C to diarrhoea in Ibadan, Nigeria. Two hundred and twenty pairs of children, matched on age, were recruited as cases and controls over a period of 5 months in Ibadan. Questionnaire and observation checklist were used to obtain information on hygiene practices from caregivers/mothers and sanitation conditions in the households of 30% of the consenting mothers/caregivers. Data were analysed using descriptive and inferential statistics. Caregivers/mothers' mean ages were 31.3 ±7.5 (cases) and 30.6 ±6.0(controls) years. The risk of diarrhoea was significantly higher among children whose mothers did not wash hands with soap before food preparation (OR=3.0, psanitation conditions within households were risk factors for diarrhoea. This study revealed the feasibility of developing and implementing an adequate model to establish intervention priorities in sanitation in Ibadan, Nigeria.

  4. Effect of multidisciplinary disease management for hospitalized heart failure under a national health insurance programme.

    Science.gov (United States)

    Mao, Chun-Tai; Liu, Min-Hui; Hsu, Kuang-Hung; Fu, Tieh-Cheng; Wang, Jong-Shyan; Huang, Yu-Yen; Yang, Ning-I; Wang, Chao-Hung

    2015-09-01

    Multidisciplinary disease management programmes (MDPs) for heart failure have been shown to be effective in Western countries. However, it is not known whether they improve outcomes in a high population density country with a national health insurance programme. In total, 349 patients hospitalized because of heart failure were randomized into control and MDP groups. All-cause death and re-hospitalization related to heart failure were analyzed. The median follow-up period was approximately 2 years. Mean patient age was 60 years; 31% were women; and 50% of patients had coronary artery disease. MDP was associated with fewer all-cause deaths [hazard ratio (HR) = 0.49, 95% confidence interval (CI) = 0.27-0.91, P = 0.02] and heart failure-related re-hospitalizations (HR = 0.44, 95% CI = 0.25-0.77, P = 0.004). MDP was still associated with better outcomes for all-cause death (HR = 0.53, 95% CI = 0.29-0.98, P = 0.04) and heart failure-related re-hospitalization (HR = 0.46, 95% CI = 0.26-0.81, P = 0.007), after adjusting for age, diuretics, diabetes mellitus, chronic kidney disease, hypertension, sodium, and albumin. However, MDPs' effect on all-cause mortality and heart failure-related re-hospitalization was significantly attenuated after adjusting for angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers or β-blockers. A stratified analysis showed that MDP combined with guideline-based medication had synergistic effects. MDP is effective in lowering all-cause mortality and re-hospitalization rates related to heart failure under a national health insurance programme. MDP synergistically improves the effectiveness of guidelines-based medications for heart failure.

  5. Die ärztliche Ausbildung in Ulm [

    Directory of Open Access Journals (Sweden)

    Debatin, Klaus-Michael

    2006-02-01

    Full Text Available [english] High numbers of students, a drop in funding, and the lack of quality in higher education teaching, when compared internationally, have led to a change in the university landscape over recent years. But medicine itself has changed, too. Under the influence of science and research, new developments in specific fields of medicine are continually arising. This change demands the development of new learning concepts for the improvement of quality in higher education. During medical training, it should be taken into account that a large part of medical activity is affected by experiences gained in clinical practice. With the inclusion of these aspects in the development of new learning concepts, the students will profit from continuous medical training. This teaching is promoted by the Federal State of Baden-Württemberg with the establishment of Centres for Competence. The location Ulm has recognised the development and curricular inclusion of e-learning as a central task. Considerable infrastructure and technology development has taken place. The methods of e-learning are now already integrated into medical training in a variety of ways. A few years ago, the Faculty of Medicine at the University of Ulm began to pursue the concept initially of analysing teaching at various points, then giving it a new base, and continually evaluating and improving quality. [german] Hohe Studentenzahlen, ein Rückgang der finanziellen Mittel und die, im internationalen Vergleich, mangelnde Qualität der Hochschullehre haben die Hochschullandschaft in den vergangenen Jahren entscheidend verändert. Aber auch die Medizin selbst verändert sich. Unter dem Einfluss von Naturwissenschaft und Forschung entstehen kontinuierlich neue Entwicklungen in den medizinischen Fachgebieten. Dieser Wandel erfordert die Entwicklung neuer Lehrkonzepte zur Verbesserung der Qualität in der Hochschulausbildung. Es sollte während der ärztlichen Ausbildung auch ber

  6. Die Freunde im und die Freude am Fernsehen

    Directory of Open Access Journals (Sweden)

    Amina Ovcina Cajacob

    2012-09-01

    Full Text Available Das Ziel der vorliegenden Arbeit besteht darin, die Wirkungen von Popstars und Popbands auf Jugendliche (13- bis 17-Jährige zu erforschen. Im Mittelpunkt der Interessen steht die Frage, welche Wirkungen aus der Rezeption von Musiksendungen (bzw. Videoclips von Musiksendern entstehen und welche Charakteristika innerhalb der aufgebauten Beziehungen zu den Stars bemerkbar sind. Andererseits wurden die Unterschiede und Parallelen zwischen parasozialen Beziehungen zu den Stars und orthosozialen Beziehungen aufgezeigt. Im Zusammenhang mit der empirischen Untersuchung bezieht sich die Autorin auf den Uses-and-Gratifications-Approach, wobei die bedürfnissbefriedigenden Wirkungen von Musikkanälen und den dazu gehörigen Popstars im Mittelpunkt stehen. Mit Hilfe des Uses-and-Gratifications-Approach wird angenommen, dass das Konsumieren der Musiksendungen und der Musikstars von den Jugendlichen gezielt zur Befriedigung bestimmter Bedürfnisse eingesetzt wird.The objective of this study is to explore the effects of pop stars on adolescents (aged between 13 and 17. The focus of interest is the question what effect music channels (i.e. video clips from music channels produce and what characteristics are noticeable from the formed relationship between adolescents and pop stars. On the other side, parallels and differences have been drawn between the para-social relationships to pop stars and ortho-social relationships. In connection with empirical study, the author also refers to Uses-and Gratification-Approach where the need satisfying effects of music channels and pop stars are in focus. With the help of Uses-and Gratification-Approach it will be assumed, that aim of watching music channels and therefore pop stars will be pointed toward the gratification of specific needs.

  7. Geologie van die Bergkwagga Nasionale Park

    Directory of Open Access Journals (Sweden)

    D. K Toerien

    1972-12-01

    Full Text Available Die geologie van die Bergkwagga Nasionale Park word behandel. Die topografie en dreinering word bespreek en gevolg deur 'n kort behandeling van die Serie Beaufort (asook doleriet intrusies soos dit in die Park voorkom. The geology of the Mountain Zebra National Park is dealt with. The topography and drainage is discussed, followed by a brief discussion of the Beaufort Series (and dolerite intrusion, as it occurs in the Park.

  8. Chirurgie in die Grieks-Romeinse era

    Directory of Open Access Journals (Sweden)

    François P. Retief

    2006-09-01

    Full Text Available In die Grieks-Romeinse era het mediese behandeling kenmerkend uit drie elemente bestaan, naamlik regimen (dieet en gesonde leefwyse, geneesmiddels en chirurgie – laasgenoemde alleen toegepas indien regimen en geneesmiddels onsuksesvol was. Bewyse van primitiewe chirurgie dateer terug na die Bronstydperk, en in Homerus se eposse is heelwat vermelding van die chirurgiese hantering van oorlogswonde, met tussenkoms van die gode. Met die koms van empiriese geneeskunde in die 5de eeu v.C. het chirurgie in die Hippokratiese Corpus prominent gefigureer met beduidende bydraes in veral die ortopediese veld en hoofbeserings. Uitbouing van anatomiese en fisiologiese kennis, gebaseer op disseksie van menslike kadawers in Alexandrië vanaf die laat 4de eeu v.C., het chirurgie ’n hupstoot gegee. Teen die Romeinse era vanaf die 2de eeu v.C. het snykundetegnieke (en -instrumente beduidend verbeter, maar is steeds oorwegend deur Griekse geneeshere beoefen. Van geneeshere is steeds verwag om al drie bovermelde terapeutiese modaliteite te bemeester, maar chirurgie het meer aansien verwerf en daar is al meer in onderafdelings van chirurgie soos oogheelkunde, vrouesiektes en verloskunde, blaaskwale en mond- en keelsnykunde gespesialiseer. Militêre geneeskunde was in die Romeinse Ryk ’n belangrike aktiwiteit, en het veral traumachirurgie uitgebou. Betreding van die buik- en toraksholtes was nie meer noodwendig fataal nie, en veeartsenykunde het tot stand gekom. Die eerste beduidende chirurgiehandboek ná die Hippokratiese Corpus is in die 1ste eeu n.C. deur Celsus opgestel. Vanaf die 3de eeu het die chirurgieberoep min vordering gemaak, die beroepstaal het mettertyd van Grieks na Latyn verander en kundigheid is later veral deur Islam-geneeshere na die Middeleeue en later oorgedra.

  9. A Review of OIE Country Status Recovery Using Vaccinate-to-Live Versus Vaccinate-to-Die Foot-and-Mouth Disease Response Policies II: Waiting Periods After Emergency Vaccination in FMD Free Countries.

    Science.gov (United States)

    Geale, D W; Barnett, P V; Clarke, G W; Davis, J; Kasari, T R

    2015-08-01

    For countries with OIE status, FMD free country where vaccination is not practised, vaccinate-to-live policies have a significant economic disincentive as the trade restriction waiting period is double that of vaccinate-to-die policies. The disposal of healthy vaccinated animals strictly for the purpose of regaining markets with debatable scientific justification is a global concern. The feasibility of aligning the waiting periods to facilitate vaccinate-to-live is explored. The first article of this two-part review (Barnett et al., 2015) explored the qualities of higher potency Foot-and-Mouth Disease (FMD) vaccines, performance of differentiating infected from vaccinated animals (DIVA) diagnostic assays particularly in vaccinates and carriers, as well as aspects of current limitations of post-outbreak surveillance. Here, the history behind the OIE waiting periods for FMD free status is reviewed as well as whether the risk of vaccinated animals and their subsequent products differ appreciably at 3 versus 6 months. It is concluded that alignment is feasible for vaccinate-to-live using higher potency FMD vaccines within the current OIE waiting period framework of 3 and 6 months blocks of time. These waiting periods reflect precedence, historical practicalities and considered expert opinion rather than a specific scientific rationale. The future lies in updated epidemiological and diagnostic technology to establish an acceptable level of statistical certainty for surveillance or target probability of freedom of FMDV (infection or circulation) not time restricted waiting periods. The OIE Terrestrial Code limits trade from a FMD free country where vaccination is not practiced to animal products and live non-vaccinated animals. The risk of FMDV in products derived from higher potency vaccinated animals is appreciably less than for countries with infected FMD status or even from a FMD free country where vaccination is practised for which the Code has Articles with

  10. Herd Immunity Against Foot-and-Mouth Disease Under Different Vaccination Practices in India.

    Science.gov (United States)

    Sharma, G K; Mahajan, S; Matura, R; Biswal, J K; Ranjan, R; Subramaniam, S; Misri, J; Bambal, R G; Pattnaik, B

    2017-08-01

    A systematic vaccination programme is ongoing in India to control the three prevailing serotypes (A, O, Asia1) of foot-and-mouth disease (FMD) virus. Under the programme, more than 120 million bovine (term bovine applicable to both cattle and buffalo in this study) population of 221 of the 666 districts in the country are being bi-annually vaccinated with trivalent vaccine since 2010. Although clinical disease has reduced in these districts because of the systematic vaccinations, an abrupt increase in the number of FMD cases was recorded in 2013. Hence, a longitudinal field study was conducted in the year 2014 to estimate the serological herd immunity level in bovines, the impact of systematic vaccinations and field efficacy of the vaccines used. Serum samples (n = 115 963) collected from 295 districts of the 18 states of the country were analysed to estimate antibody titres against structural proteins of the three serotypes. The efficacy of the vaccine was demonstrated in the control group (group-D) where animals of the group were identified by ear tags for the purpose of repeated sampling after vaccination. Progressive building of the herd immunity in the field after systematic vaccination was demonstrated. The mean antibody titre against the serotypes O, A and Asia1 was estimated as log 10 1.93 (95% CI 1.92-1.93), 2.02 (2.02-2.02) and 2.02 (2.02-2.02), respectively, in the states covered under the control programme. However, in other states herd immunity was significantly low [mean titre log 10 1.68 (95% CI 1.67-1.69), 1.77 (1.76-1.78) and 1.85 (1.84-1.86) against the three serotypes]. Inverse relationship between the herd immunity and FMD incidences was observed the states following different vaccination practices. The study helped in demarcation of FMD risk zones in the country with low herd immunity. Estimation of herd immunity kinetics in the field helped in refining the vaccination schedule under the control programme. © 2016 Blackwell Verlag GmbH.

  11. Do heart failure disease management programs make financial sense under a bundled payment system?

    Science.gov (United States)

    Eapen, Zubin J; Reed, Shelby D; Curtis, Lesley H; Hernandez, Adrian F; Peterson, Eric D

    2011-05-01

    Policy makers have proposed bundling payments for all heart failure (HF) care within 30 days of an HF hospitalization in an effort to reduce costs. Disease management (DM) programs can reduce costly HF readmissions but have not been economically attractive for caregivers under existing fee-for-service payment. Whether a bundled payment approach can address the negative financial impact of DM programs is unknown. Our study determined the cost-neutral point for the typical DM program and examined whether published HF DM programs can be cost saving under bundled payment programs. We used a decision analytic model using data from retrospective cohort studies, meta-analyses, 5 randomized trials evaluating DM programs, and inpatient claims for all Medicare beneficiaries discharged with an HF diagnosis from 2001 to 2004. We determined the costs of DM programs and inpatient care over 30 and 180 days. With a baseline readmission rate of 22.9%, the average cost for readmissions over 30 days was $2,272 per patient. Under base-case assumptions, a DM program that reduced readmissions by 21% would need to cost $477 per patient to be cost neutral. Among evaluated published DM programs, 2 of the 5 would increase provider costs (+$15 to $283 per patient), whereas 3 programs would be cost saving (-$241 to $347 per patient). If bundled payments were broadened to include care over 180 days, then program saving estimates would increase, ranging from $419 to $1,706 per patient. Proposed bundled payments for HF admissions provide hospitals with a potential financial incentive to implement DM programs that efficiently reduce readmissions. Copyright © 2011 Mosby, Inc. All rights reserved.

  12. Evaluation of cardiovascular risk in patients with Parkinson disease under levodopa treatment.

    Science.gov (United States)

    Günaydın, Zeki Yüksel; Özer, Fahriye Feriha; Karagöz, Ahmet; Bektaş, Osman; Karataş, Mehmet Baran; Vural, Aslı; Bayramoğlu, Adil; Çelik, Abdullah; Yaman, Mehmet

    2016-01-01

    Levodopa is the indispensable choice of medial therapy in patients with Parkinson disease (PD). Since L-dopa treatment was shown to increase serum homocysteine levels, a well-known risk factor for cardiovascular disorders, the patients with PD under L-dopa treatment will be at increased risk for future cardiovascular events. The objective of this study is to evaluate cardiovascular risk in patients with PD under levodopa treatment. The study population consisted of 65 patients with idiopathic PD under L-dopa treatment. The control group included 32 age and gender matched individuals who had no cognitive decline. Echocardiographic measurements, serum homocysteine levels and elastic parameters of the aorta were compared between the patients with PD and controls. As an expected feature of L-dopa therapy, the Parkinson group had significantly higher homocystein levels (15.1 ± 3.9 µmol/L vs. 11.5 ± 3.2 µmol/L, P = 0.02). Aortic distensibility was significantly lower in the patients with PD when compared to controls (4.8 ± 1.5 dyn/cm(2) vs. 6.2 ± 1.9 dyn/cm(2), P = 0.016). Additionally, the patients with PD had higher aortic strain and aortic stiffness index (13.4% ± 6.4% vs. 7.4% ± 3.6%, P homocysteine levels were found to be positively correlated with aortic stiffness index and there was a negative correlation between aortic distensibility and levels of serum homocysteine (r = 0.674, P homocysteine levels may be a possible pathophysiological mechanism.

  13. Under-Expression of Chemosensory Genes in Domiciliary Bugs of the Chagas Disease Vector Triatoma brasiliensis.

    Science.gov (United States)

    Marchant, Axelle; Mougel, Florence; Jacquin-Joly, Emmanuelle; Costa, Jane; Almeida, Carlos Eduardo; Harry, Myriam

    2016-10-01

    In Latin America, the bloodsucking bugs Triatominae are vectors of Trypanosoma cruzi, the parasite that causes Chagas disease. Chemical elimination programs have been launched to control Chagas disease vectors. However, the disease persists because native vectors from sylvatic habitats are able to (re)colonize houses-a process called domiciliation. Triatoma brasiliensis is one example. Because the chemosensory system allows insects to interact with their environment and plays a key role in insect adaption, we conducted a descriptive and comparative study of the chemosensory transcriptome of T. brasiliensis samples from different ecotopes. In a reference transcriptome built using de novo assembly, we found transcripts encoding 27 odorant-binding proteins (OBPs), 17 chemosensory proteins (CSPs), 3 odorant receptors (ORs), 5 transient receptor potential channel (TRPs), 1 sensory neuron membrane protein (SNMPs), 25 takeout proteins, 72 cytochrome P450s, 5 gluthatione S-transferases, and 49 cuticular proteins. Using protein phylogenies, we showed that most of the OBPs and CSPs for T. brasiliensis had well supported orthologs in the kissing bug Rhodnius prolixus. We also showed a higher number of these genes within the bloodsucking bugs and more generally within all Hemipterans compared to the other species in the super-order Paraneoptera. Using both DESeq2 and EdgeR software, we performed differential expression analyses between samples of T. brasiliensis, taking into account their environment (sylvatic, peridomiciliary and domiciliary) and sex. We also searched clusters of co-expressed contigs using HTSCluster. Among differentially expressed (DE) contigs, most were under-expressed in the chemosensory organs of the domiciliary bugs compared to the other samples and in females compared to males. We clearly identified DE genes that play a role in the chemosensory system. Chemosensory genes could be good candidates for genes that contribute to adaptation or plastic

  14. Under-Expression of Chemosensory Genes in Domiciliary Bugs of the Chagas Disease Vector Triatoma brasiliensis.

    Directory of Open Access Journals (Sweden)

    Axelle Marchant

    2016-10-01

    Full Text Available In Latin America, the bloodsucking bugs Triatominae are vectors of Trypanosoma cruzi, the parasite that causes Chagas disease. Chemical elimination programs have been launched to control Chagas disease vectors. However, the disease persists because native vectors from sylvatic habitats are able to (recolonize houses-a process called domiciliation. Triatoma brasiliensis is one example. Because the chemosensory system allows insects to interact with their environment and plays a key role in insect adaption, we conducted a descriptive and comparative study of the chemosensory transcriptome of T. brasiliensis samples from different ecotopes.In a reference transcriptome built using de novo assembly, we found transcripts encoding 27 odorant-binding proteins (OBPs, 17 chemosensory proteins (CSPs, 3 odorant receptors (ORs, 5 transient receptor potential channel (TRPs, 1 sensory neuron membrane protein (SNMPs, 25 takeout proteins, 72 cytochrome P450s, 5 gluthatione S-transferases, and 49 cuticular proteins. Using protein phylogenies, we showed that most of the OBPs and CSPs for T. brasiliensis had well supported orthologs in the kissing bug Rhodnius prolixus. We also showed a higher number of these genes within the bloodsucking bugs and more generally within all Hemipterans compared to the other species in the super-order Paraneoptera. Using both DESeq2 and EdgeR software, we performed differential expression analyses between samples of T. brasiliensis, taking into account their environment (sylvatic, peridomiciliary and domiciliary and sex. We also searched clusters of co-expressed contigs using HTSCluster. Among differentially expressed (DE contigs, most were under-expressed in the chemosensory organs of the domiciliary bugs compared to the other samples and in females compared to males. We clearly identified DE genes that play a role in the chemosensory system.Chemosensory genes could be good candidates for genes that contribute to adaptation or

  15. Under-Expression of Chemosensory Genes in Domiciliary Bugs of the Chagas Disease Vector Triatoma brasiliensis

    Science.gov (United States)

    Marchant, Axelle; Mougel, Florence; Jacquin-Joly, Emmanuelle; Costa, Jane; Almeida, Carlos Eduardo; Harry, Myriam

    2016-01-01

    Background In Latin America, the bloodsucking bugs Triatominae are vectors of Trypanosoma cruzi, the parasite that causes Chagas disease. Chemical elimination programs have been launched to control Chagas disease vectors. However, the disease persists because native vectors from sylvatic habitats are able to (re)colonize houses—a process called domiciliation. Triatoma brasiliensis is one example. Because the chemosensory system allows insects to interact with their environment and plays a key role in insect adaption, we conducted a descriptive and comparative study of the chemosensory transcriptome of T. brasiliensis samples from different ecotopes. Methodology/Principal Finding In a reference transcriptome built using de novo assembly, we found transcripts encoding 27 odorant-binding proteins (OBPs), 17 chemosensory proteins (CSPs), 3 odorant receptors (ORs), 5 transient receptor potential channel (TRPs), 1 sensory neuron membrane protein (SNMPs), 25 takeout proteins, 72 cytochrome P450s, 5 gluthatione S-transferases, and 49 cuticular proteins. Using protein phylogenies, we showed that most of the OBPs and CSPs for T. brasiliensis had well supported orthologs in the kissing bug Rhodnius prolixus. We also showed a higher number of these genes within the bloodsucking bugs and more generally within all Hemipterans compared to the other species in the super-order Paraneoptera. Using both DESeq2 and EdgeR software, we performed differential expression analyses between samples of T. brasiliensis, taking into account their environment (sylvatic, peridomiciliary and domiciliary) and sex. We also searched clusters of co-expressed contigs using HTSCluster. Among differentially expressed (DE) contigs, most were under-expressed in the chemosensory organs of the domiciliary bugs compared to the other samples and in females compared to males. We clearly identified DE genes that play a role in the chemosensory system. Conclusion/Significance Chemosensory genes could be good

  16. Die invloed van klimaatverandering op die Suid-Afrikaanse stad en ...

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    Opsomming. Die doel van hierdie artikel is om die effek van klimaatverandering op die Suid-. Afrikaanse stad te ondersoek en toepaslike maatreëls aan die hand te doen, gebaseer op die spesifieke klimaatstreek. Met toenemende klimaatverandering word dit al hoe belangriker dat Suid-Afrikaanse stede veerkragtig ...

  17. n hoofstuk in die (outo)biografie van die predikant (pastor?) 1 ...

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    Karel Schoeman onthou in Die uur van die engel seuntjies in grys of donkerblou Sondagpakkies, die hare platgestryk met haarolie, en die dogtertjies in wit rokkies en strooihoede met blomkransies; hy onthou vir dominee Hamman op die preekstoel, swart en regop soos 'n granietsuil (Schoeman 1995:21; my kursivering).

  18. DIE ROL VAN DIE SUID-AFRIKAANSE WEERMAG IN NATUUR- EN ...

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    sedert die vroeg 1900's deur die Weermag be- heer. In 1967 was dit die eerste militere terrein wat tot privaatnatuurreservaat verklaar is. Vhembe bestaan uit 4 hoofplantgemeenskappe nl. rivieraewerbos, vloedvlaktes, ranteveld en die sandveldplato. Wildsoorte op die terrein sl!Jit rooibokke, bosbokke, waterbokke, koedoes,.

  19. see van Galilea gegaan in die middel van die Tienstede-gebied". AS ...

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    Die behandeling van hierdie onderwerpe is van heel ongelyke lengte en ook wel verskillend van gehalte. Die historiese uiteensettings lyk my aanmerklik beter geslaag as die sistematies-teologiese, hoewel ook daarin die hoofsake m.i. reg gestel word en tereg sowel teen die historisme as teen sekere teses en uitgroeisels ...

  20. kilometer 500, die beeindiging van die suidwes-afrika-kampanje 70 ...

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    slaan was. Die tentklappe van die tent was ver opgeklap om genoegsame lig binne die tent te verskaf en vrye toegang na en beweging in die tent moontlik te maak. Enkele foto's oor die geskiedkundige gebeurte- nis by Kilometer 500 op 9 Julie 1915, toon aan. Scientia Militaria, South African Journal of Military Studies, Vol ...