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Sample records for under-recovery occurring simultaneously

  1. Simultaneous pollinator occurence (Hymenoptera, Agaoninae) in a threatened species: Ficus mexiae Standley (Moraceae).

    Science.gov (United States)

    Schiffler, G; Kloss, T G; Matos, J R

    2013-08-01

    In Brazil, Ficus mexiae is classified as Vulnerable under IUCN criteria, and to date there is only one report on pollinator activity for this species. Is not unusual to find cases where more than one species of wasp simultaneously occurs on and pollinates the same fig. In this study we present evidence that two Pegoscapus wasp species contribute to the pollination of F. mexiae and relationship between pollinators maybe competitive. These results indicate that the F. mexiae population represent an important element in the complex dynamics of maintaining diversity in neotropical Ficus spp.

  2. Clinical characteristics and HLA alleles of a family with simultaneously occurring alopecia areata.

    Science.gov (United States)

    Emre, Selma; Metin, Ahmet; Caykoylu, Ali; Akoglu, Gulsen; Ceylan, Gülay G; Oztekin, Aynure; Col, Esra S

    2016-06-01

    Alopecia areata (AA) is a T-cell-mediated autoimmune disease resulting in partial or total noncicatricial hair loss. HLA class II antigens are the most important markers that constitute genetic predisposition to AA. Various life events and intense psychological stress may play an important role in triggering AA attacks. We report an unusual case series of 4 family members who had simultaneously occurring active AA lesions. Our aim was to evaluate the clinical and psychiatric features of 4 cases of active AA lesions occurring simultaneously in a family and determine HLA alleles. The clinical and psychological features of all patients were examined. HLA antigen DNA typing was performed by polymerase chain reaction with sequence-specific primers. All patients had typical AA lesions over the scalp and/or beard area. Psychological examinations revealed obsessive-compulsive personality disorder in the proband's parents as well as anxiety and lack of self-confidence in both the proband and his sister. HLA antigen types were not commonly shared with family members. These findings suggest that AA presenting concurrently in members of the same family was not associated with genetic predisposition. Shared psychological disorders and stressful life events might be the major key points in the concurrent presentation of these familial AA cases and development of resistance against treatments.

  3. Patterns of oxygen consumption during simultaneously occurring elevated metabolic states in the viviparous snake Thamnophis marcianus.

    Science.gov (United States)

    Jackson, Alexander G S; Leu, Szu-Yun; Ford, Neil B; Hicks, James W

    2015-11-01

    Snakes exhibit large factorial increments in oxygen consumption during digestion and physical activity, and long-lasting sub-maximal increments during reproduction. Under natural conditions, all three physiological states may occur simultaneously, but the integrated response is not well understood. Adult male and female checkered gartersnakes (Thamnophis marcianus) were used to examine increments in oxygen consumption (i.e. V̇(O2)) and carbon dioxide production (i.e. V̇(CO2)) associated with activity (Act), digestion (Dig) and post-prandial activity (Act+Dig). For females, we carried out these trials in the non-reproductive state, and also during the vitellogenic (V) and embryogenic (E) phases of a reproductive cycle. Endurance time (i.e. time to exhaustion, TTE) was recorded for all groups during Act and Act+Dig trials. Our results indicate that male and non-reproductive female T. marcianus exhibit significant increments in V̇(O2) during digestion (∼5-fold) and activity (∼9-fold), and that Act+Dig results in a similar increment in V̇(O2) (∼9- to 10-fold). During reproduction, resting V̇(O2) increased by 1.6- to 1.7-fold, and peak increments during digestion were elevated by 30-50% above non-reproductive values, but values associated with Act and Act+Dig were not significantly different from non-reproductive values. During Act+Dig, endurance time remained similar for all of the groups in the present study. Overall, our results indicate that prioritization is the primary pattern of interaction in oxygen delivery exhibited by this species. We propose that the metabolic processes associated with digestion, and perhaps reproduction, are temporarily compromised during activity. © 2015. Published by The Company of Biologists Ltd.

  4. Quantification of multiple simultaneously occurring nitrogen flows in the euphotic ocean

    Science.gov (United States)

    Xu, Min Nina; Wu, Yanhua; Zheng, Li Wei; Zheng, Zhenzhen; Zhao, Huade; Laws, Edward A.; Kao, Shuh-Ji

    2017-03-01

    The general features of the N cycle in the sunlit region of the ocean are well known, but methodological difficulties have previously confounded simultaneous quantification of transformation rates among the many different forms of N, e.g., ammonium (NH4+), nitrite (NO2-), nitrate (NO3-), and particulate/dissolved organic nitrogen (PN/DON). However, recent advances in analytical methodology have made it possible to employ a convenient isotope labeling technique to quantify in situ fluxes among oft-measured nitrogen species within the euphotic zone. Addition of a single 15N-labeled NH4+ tracer and monitoring of the changes in the concentrations and isotopic compositions of the total dissolved nitrogen (TDN), PN, NH4+, NO2-, and NO3- pools allowed us to quantify the 15N and 14N fluxes simultaneously. Constraints expressing the balance of 15N and 14N fluxes between the different N pools were expressed in the form of simultaneous equations, the unique solution of which via matrix inversion yielded the relevant N fluxes, including rates of NH4+, NO2-, and NO3- uptake; ammonia oxidation; nitrite oxidation; DON release; and NH4+ uptake by bacteria. The matrix inversion methodology that we used was designed specifically to analyze the results of incubations under simulated in situ conditions in the euphotic zone. By taking into consideration simultaneous fluxes among multiple N pools, we minimized potential artifacts caused by non-targeted processes in traditional source-product methods. The proposed isotope matrix method facilitates post hoc analysis of data from on-deck incubation experiments and can be used to probe effects of environmental factors (e.g., pH, temperature, and light) on multiple processes under controlled conditions.

  5. H(+) -pyrophosphatase from Salicornia europaea confers tolerance to simultaneously occurring salt stress and nitrogen deficiency in Arabidopsis and wheat.

    Science.gov (United States)

    Lv, Sulian; Jiang, Ping; Nie, Lingling; Chen, Xianyang; Tai, Fang; Wang, Duoliya; Fan, Pengxiang; Feng, Juanjuan; Bao, Hexigeduleng; Wang, Jinhui; Li, Yinxin

    2015-11-01

    High salinity and nitrogen (N) deficiency in soil are two key factors limiting crop productivity, and they usually occur simultaneously. Here we firstly found that H(+) -PPase is involved in salt-stimulated NO3 (-) uptake in the euhalophyte Salicornia europaea. Then, two genes (named SeVP1 and SeVP2) encoding H(+) -PPase from S. europaea were characterized. The expression of SeVP1 and SeVP2 was induced by salt stress and N starvation. Both SeVP1 or SeVP2 transgenic Arabidopsis and wheat plants outperformed the wild types (WTs) when high salt and low N occur simultaneously. The transgenic Arabidopsis plants maintained higher K(+) /Na(+) ratio in leaves and exhibited increased NO3 (-) uptake, inorganic pyrophosphate-dependent vacuolar nitrate efflux and assimilation capacity under this double stresses. Furthermore, they had more soluble sugars in shoots and roots and less starch accumulation in shoots than WT. These performances can be explained by the up-regulated expression of ion, nitrate and sugar transporter genes in transgenic plants. Taken together, our results suggest that up-regulation of H(+) -PPase favours the transport of photosynthates to root, which could promote root growth and integrate N and carbon metabolism in plant. This work provides potential strategies for improving crop yields challenged by increasing soil salinization and shrinking farmland. © 2015 John Wiley & Sons Ltd.

  6. Type III talon cusp and Type III B dens invaginatus occurring simultaneously in a mandibular lateral incisor.

    Science.gov (United States)

    Dharmani, Umesh; Rajput, Akhil; Chaudhary, Sarika; Talwar, Sangeeta; Verma, Mahesh

    2014-01-01

    Talon cusp and dens invaginatus are developmental anomalies of the human dentition. They not only affect the esthetic appearance of teeth but also may create difficulties during dental treatment and lead to a number of dental problems. Both anomalies are observed most commonly in the lateral maxillary incisor and rarely in the mandibular dentition. The simultaneous occurrence of talon cusp and dens invaginatus in a single tooth is very rare in the mandibular dentition and, to the authors' knowledge, has not yet been reported in a mandibular lateral incisor. This article presents a rare case of dens invaginatus and talon cusp occurring concurrently in a mandibular lateral incisor. Three-dimensional imaging modality was used to describe the complex internal anatomy.

  7. Multi-instrument observation of two different types of polar cap aurora occurring simultaneously during northward IMF

    Science.gov (United States)

    Reidy, J. A.; Fear, R. C.; Lanchester, B. S.; Whiter, D. K.; Kavanagh, A. J.; Paxton, L. J.; Zhang, Y.

    2016-12-01

    Polar cap aurora are a phenomena associated with periods of northwards IMF. By studying their appearance and formation, we can gain valuable information on the configuration of Earth's magnetosphere during the less understood `quiet' periods that occur approximately half of the time. Observations of high latitude aurora from multiple instruments on 19 January 2008 are presented, including almost simultaneous observations of the northern and southern auroral regions from the Special Sensor Ultra-violet Spectrographic Imager (SSUSI) instruments on board Defence Meteorological Satellite Programme (DMSP) spacecraft F16 and F17. SuperDARN flows are also explored in both hemispheres during the event. In the northern hemisphere, two high latitude structures were seen on opposite sides of the polar cap during the same interval. The energies of the precipitating electrons above the structure on the duskside was estimated to vary between 2-11 keV using the Auroral Structure and Kinetics (ASK) instrument in conjunction with the Southampton ion chemistry model. Further analysis of this structure revealed it to be formed on closed field lines that had protruded into the polar cap, consistent with the mechanism proposed for transpolar arcs. However this structure did not cross the entire polar cap but remained, in the northern hemisphere, at approximately 80° magnetic latitude for at least 40 minutes. This protrusion is hence suggested to be an example of a `failed transpolar arc'. The structure seen on the dawnside of the northern polar cap was analysed using DMSP particle spectrograph data. It was found to be associated with electron precipitation energies lower than 1 keV and no ion signature were present. Hence it is suggested that this sun-aligned structure is consistent with the common low intensity arcs formed by accelerated polar rain. The study shows there are at least two types of high latitude aurora occurring simultaneously during northwards IMF.

  8. Simultaneously Occurring Elevated Metabolic States Expose Constraints in Maximal Levels of Oxygen Consumption in the Oviparous Snake Lamprophis fuliginosus.

    Science.gov (United States)

    Jackson, Alexander Garrett Schavran; Leu, Szu-Yun; Hicks, James W

    African house snakes (Lamprophis fuliginosus) were used to compare the metabolic increments associated with reproduction, digestion, and activity both individually and when combined simultaneously. Rates of oxygen consumption ([Formula: see text]) and carbon dioxide production ([Formula: see text]) were measured in adult female (nonreproductive and reproductive) and adult male snakes during rest, digestion, activity while fasting, and postprandial activity. We also compared the endurance time (i.e., time to exhaustion) during activity while fasting and postprandial activity in males and females. For nonreproductive females and males, our results indicate that the metabolic increments of digestion (∼3-6-fold) and activity while fasting (∼6-10-fold) did not interact in an additive fashion; instead, the aerobic scope associated with postprandial activity was 40%-50% lower, and animals reached exhaustion up to 11 min sooner. During reproduction, there was no change in digestive [Formula: see text], but aerobic scope for activity while fasting was 30% lower than nonreproductive values. The prioritization pattern of oxygen delivery exhibited by L. fuliginosus during postprandial activity (in both males and females) and for activity while fasting (in reproductive females) was more constrained than predicted (i.e., instead of unchanged [Formula: see text], peak values were 30%-40% lower). Overall, our results indicate that L. fuliginosus's cardiopulmonary system's capacity for oxygen delivery was not sufficient to maintain the metabolic increments associated with reproduction, digestion, and activity simultaneously without limiting aerobic scope and/or activity performance.

  9. Single-cell Hi-C for genome-wide detection of chromatin interactions that occur simultaneously in a single cell.

    Science.gov (United States)

    Nagano, Takashi; Lubling, Yaniv; Yaffe, Eitan; Wingett, Steven W; Dean, Wendy; Tanay, Amos; Fraser, Peter

    2015-12-01

    Hi-C is a powerful method that provides pairwise information on genomic regions in spatial proximity in the nucleus. Hi-C requires millions of cells as input and, as genome organization varies from cell to cell, a limitation of Hi-C is that it only provides a population average of genome conformations. We developed single-cell Hi-C to create snapshots of thousands of chromatin interactions that occur simultaneously in a single cell. To adapt Hi-C to single-cell analysis, we modified the protocol to include in-nucleus ligation. This enables the isolation of single nuclei carrying Hi-C-ligated DNA into separate tubes, followed by reversal of cross-links, capture of biotinylated ligation junctions on streptavidin-coated magnetic beads and PCR amplification of single-cell Hi-C libraries. The entire laboratory protocol can be carried out in 1 week, and although we have demonstrated its use in mouse T helper (TH1) cells, it should be applicable to any cell type or species for which standard Hi-C has been successful. We also developed an analysis pipeline to filter noise and assess the quality of data sets in a few hours. Although the interactome maps produced by single-cell Hi-C are sparse, the data provide useful information to understand cellular variability in nuclear genome organization and chromosome structure. Standard wet and dry laboratory skills in molecular biology and computational analysis are required.

  10. One-step Multiplex RT-PCR Method for Simultaneous Detection of Seed Transmissible Bacterium and Virus Occurring on Brassicaceae Crop Seeds

    Directory of Open Access Journals (Sweden)

    Kyusik Jeong

    2011-04-01

    Full Text Available The aim of this research was to develop specific and sensitive PCR-based procedures for simultaneous detection of economically important plant pathogenic bacteria and seed borne virus in commercial Brassicaceae crop seeds, Xanthomonns campestris pv. campestris (Xcc and Lettuce Mosaic Virus (LMV. Bacterial and virus diseases of Brassicaceae leaves are responsible for heavy losses. PCR with arbitral primers: selection of specific primers, performance of PCR with specific primers and determination of the threshold level for pathogens detection. To detect simultaneously the Xcc and LMV in commercial Brassicaceae crop seeds (lettuce, kohlrabi, radish, chinese cabbage and cabbage, two pairs of specific primer (LMV-F/R, Xcc-F/R were synthesized by using primer-blast program (http://www.ncbi.nlm.nih.gov/tools/ primer-blast/. The multiplex PCR for the two pathogens in Brassicaceae crop seeds could detect specifically without interference among primers and/or cDNA of other plant pathogens. The pathogen detection limit was determined at 1 ng of RNA extracted from pathogens. In the total PCR results for pathogen detection using commercial kohlrabi (10 varieties, lettuce (50 varieties, radish (20 varieties, chinese cabbage (20 varieties and cabbage (20 varieties, LMV and Xcc were detected from 39 and 2 varieties, respectively. In the PCR result of lettuce, LMV and Xcc were simultaneously detected in 8 varieties.

  11. Multiple primary cancers: Simultaneously occurring prostate cancer ...

    African Journals Online (AJOL)

    We also reviewed the existing literatures for possible biologic links between prostatic carcinoma and other primary tumors. ... The primary tumors co-existing with prostate cancer were colonic adenocarcinoma, rectal adenocarcinoma, urinary bladder transitional cell carcinoma, primary liver cell carcinoma, and thyroid ...

  12. Multiple Primary Cancers: Simultaneously Occurring Prostate ...

    African Journals Online (AJOL)

    2016-05-20

    May 20, 2016 ... 2017 Nigerian Journal of Clinical Practice | Published by Wolters Kluwer - Medknow ... had metastatic diseases at presentation and more than .... the colonic tumor. The patient with co-existing rectal tumor posed a diagnostic dilemma which required immunohistochemistry to differentiate the rectal tumor.

  13. Simultaneous consolidation and creep

    DEFF Research Database (Denmark)

    Krogsbøll, Anette

    1997-01-01

    Materials that exhibit creep under constant effective stress typically also show rate dependent behavior. The creep deformations and the rate sensitive behavior is very important when engineering and geological problems with large time scales are considered. When stress induced compaction (consol...... (consolidation) is retarded by slow drainage of excess pore pressure it is expected that consolidation and creep occur simultaneously. A constitutive model adressing the problems of rate sensitive behavior and simultaneous consolidation and creep is presented....

  14. Simultaneous Bilateral Anterior Shoulder Dislocation Occurred During Sleepwalking

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    fevzi yilmaz

    2013-10-01

    A 17-years-old male presented to our emergency department with a complaint of bilateral shoulder pain and motion restriction. His past medical history was unremarkable for epilepsy or major trauma. His family members said that he was a sleepwalker since he was 5 or 6 years old and sometimes he was going to another place from his bed and when they saw him there were abrasions especially on his face and extremities. It was learned that he left the drugs given by the doctors for his complaint after using a short time. On his physical examination in the emergency department he appeared to be good, he was concious, cooperative and oriented to person, time and place. His vital signs and neurological examination were normal. His extremity examination revealed that his arms were slightly in abduction and external rotation. There was epaulet sign bilateral on his shoulders and his peripheral neurological examination was otherwise normal. The radiological evaluation revealed bilateral subchorocoidal anterior dislocation without signs of fracture (Figure 1.

  15. Simultaneous Cake Cutting

    DEFF Research Database (Denmark)

    Balkanski, Eric; Branzei, Simina; Kurokawa, David

    2014-01-01

    We introduce the simultaneous model for cake cutting (the fair allocation of a divisible good), in which agents simultaneously send messages containing a sketch of their preferences over the cake. We show that this model enables the computation of divisions that satisfy proportionality — a popular...

  16. Angiodysplasia Occurring in Jejunal Diverticulosis

    OpenAIRE

    1990-01-01

    The first case of angiodysplasia occurring in acquired jejunal diverticulosis is reported. The patient presented with occult gastrointestinal bleeding and chronic anemia, and was created successfully by resection of a 25 cm long segment of jejunum. Possible pathogenetic mechanisms for both angiodysplasia and jejunal diverticulosis are discussed.

  17. Chromosomal rearrangements occurred repeatedly and ...

    African Journals Online (AJOL)

    Furthermore, molecular and/or chromosomal data indicate that Paroedura is a monophyletic genus, in which chromosome rearrangements occurred repeatedly and independently during the specific diversification. Moreover both P. bastardi and P. gracilis in current definitions are paraphyletic assemblages of several ...

  18. Experimental simulation of simultaneous vision.

    Science.gov (United States)

    de Gracia, Pablo; Dorronsoro, Carlos; Sánchez-González, Álvaro; Sawides, Lucie; Marcos, Susana

    2013-01-17

    To present and validate a prototype of an optical instrument that allows experimental simulation of pure bifocal vision. To evaluate the influence of different power additions on image contrast and visual acuity. The instrument provides the eye with two superimposed images, aligned and with the same magnification, but with different defocus states. Subjects looking through the instrument are able to experience pure simultaneous vision, with adjustable refractive correction and addition power. The instrument is used to investigate the impact of the amount of addition of an ideal bifocal simultaneous vision correction, both on image contrast and on visual performance. the instrument is validated through computer simulations of the letter contrast and by equivalent optical experiments with an artificial eye (camera). Visual acuity (VA) was measured in four subjects (AGE: 34.3 ± 3.4 years; spherical error: -2.1 ± 2.7 diopters [D]) for low and high contrast letters and different amounts of addition. The largest degradation in contrast and visual acuity (∼25%) occurred for additions around ±2 D, while additions of ±4 D produced lower degradation (14%). Low additions (1-2 D) result in lower VA than high additions (3-4 D). A simultaneous vision instrument is an excellent tool to simulate bifocal vision and to gain understanding of multifocal solutions for presbyopia. Simultaneous vision induces a pattern of visual performance degradation, which is well predicted by the degradation found in image quality. Neural effects, claimed to be crucial in the patients' tolerance of simultaneous vision, can be therefore compared with pure optical effects.

  19. Simultaneous Bilateral Bell's palsy in a Nigerian man | Owolabi ...

    African Journals Online (AJOL)

    Bilateral Bellfs palsy occurring simultaneously is exceedingly rare. We report a case of a 27.year.old Nigerian man with bilateral Bellfs palsy, that occurred simultaneously, who had remarkable response to steroid and physiotherapy. We emphasized the importance of considering Bellfs palsy and the various differential ...

  20. Early occurring and continuing effects

    International Nuclear Information System (INIS)

    Scott, B.R.; Hahn, F.F.

    1985-01-01

    This chapter deals with health-risk estimates for early and continuing effects of exposure to ionizing radiations that could be associated with light water nuclear power plants accidents. Early and continuing effects considered are nonneoplastic diseases and symptoms that normally occur soon after radiation exposure, but may also occur after years have passed. They are generally associated with relatively high (greater than 1 Gy) doses. For most of the effects considered, there is a practical dose threshold. Organs of primary interest, because of their high sensitivity or the likelihood of receiving a large radiation dose, are bone marrow, gastrointestinal tract, thyroid glands, lungs, skin, gonads, and eyes. In utero exposure of the fetus is also considered. New data and modeling techniques available since publication of the Reactor Safety Study (WASH 1400, 1975) were used along with data cited in the Study to develop improved health-risk models for morbidity and mortality. The new models are applicable to a broader range of accident scenarios, provide a more detailed treatment of dose protraction effects, and include morbidity effects not considered in the Reactor Safety Study. 115 references, 20 figures, 19 tables

  1. Simultaneity, relativity and conventionality

    Science.gov (United States)

    Janis, Allen I.

    2008-01-01

    The view of simultaneity presented by Max Jammer is almost breathtaking, encompassing, as the book's subtitle suggests, the period from antiquity to the 21st century. Many interesting things are to be found along the way. For example, what Jammer (p. 49) says "may well be regarded as probably the earliest recorded example of an operational definition of distant simultaneity" is due to St. Augustine (in his Confessions, written in 397 A.D.; for a modern translation, see Augustine, 2006). He was arguing against astrology by presenting the story of two women, one rich and one poor, who gave birth simultaneously. Although the two children thus had precisely the same horoscopes, their lives followed quite different courses. And how was it determined that the births were simultaneous? A messenger went from each birth site to the other, leaving the instant the child was born (and, presumably, traveling with equal speeds). Since the messengers met at the midpoint between the locations of the two births, the births must have been simultaneous. This is, of course, quite analogous to Albert Einstein's definition of simultaneity (given more than 1500 years later), which will be discussed in Section 2.1.

  2. Bilateral simultaneous infective keratitis.

    Science.gov (United States)

    On Annie, Lai Hiu; Ray, Manotosh

    2017-08-01

    To analyze the demographics, risk factors, clinical and microbiological characteristics of cases of bilateral simultaneous infective keratitis. In this retrospective case series, patients with clinical evidence of bilateral simultaneous infective keratitis were identified from January 1, 2011 to August 31, 2016. Demographics, risk factors, clinical and microbiological characteristics, and treatment outcomes were analyzed. Five patients (ten eyes) with bilateral simultaneous infective keratitis were identified. The mean age was 32.8 years (SD,±8.8; range, 24-44). All the patients were disposable soft contact lens wearers before presentation. The average size of the infiltrate was 4.76mm 2 (SD±9.0; range, 0.2-31.34). A total of 4 types of bacteria were isolated, with Pseudomonas aeruginosa being the most frequently isolated bacteria involving 5 eyes of four patients. Infection resolved with medical treatment in 9 eyes, 1 patient required therapeutic corneal transplantation for impending corneal perforation. The average time taken for infection to resolve was 6.7days (SD±4.5; range, 2-16). In this case series, the most common risk factor of bilateral simultaneous microbial keratitis was use of soft disposable contact lens and the most commonly isolated bacteria was Pseudomonas aeruginosa. Bilateral simultaneous infective keratitis is uncommon and is a serious complication of contact lens use in immunocompetent adult patients. Copyright © 2017 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

  3. Does overtraining occur in triathletes?

    Directory of Open Access Journals (Sweden)

    I Margaritis

    2003-06-01

    Full Text Available 1. Objective: Long distance triathlon training is characterized by considerably high volume training loads. This volume can provoke an overtraining state. The aim of the study was to determine whether overtraining occurs in well-trained male triathletes in relation with their volume training loads. 2. Experimental design: A questionnaire investigation was completed two days before the Nice long-distance triathlon (October 1995: 4-km swim, 120-km bike ride and 30-km run. 3. Participants: Ninety-three well-trained male triathletes who took part in the triathlon race. 4. Measures: A questionnaire to relate clinical symptoms, which are known to appear in case of overtraining, was collected. 5. Results: 39.8% of the questioned triathletes reported a decrease in triathlon performances within the last month preceding the race. Moreover, these triathletes exhibited significantly more overtraining-relied symptoms than the others (5.9±3.8 vs 3.4±2.6, P<0.05. Surprisingly, the occurrence of overtraining in triathletes appears not to depend on the volume training loads. 6. Conclusions: These results suggest that overtraining has to be considered in the case of triathletes. This preliminary study evidences the need for further investigation in order to monitor triathletes training respond and prevent overtraining.

  4. Earl occurring and continuing effects

    International Nuclear Information System (INIS)

    Scott, B.R.; Hahn, F.F.

    1989-01-01

    This chapter develops health-risk models for early and continuing effects of exposure to beta or gamma radiation that could be associated with light water nuclear power plant accidents. The main purpose of the chapter is to provide details on each health-risk model and on the data used. Early and continuing effects considered are prodromal symptoms and nonneoplastic diseases that usually occur soon after a brief radiation exposure. These effects are generally associated with relatively high (greater than 1 Gy) absorbed organ doses. For most of the effects considered, there is an absorbed organ dose threshold below which no effects are seen. Some information is provided on health effects observed in victims of the Chernobyl power plant accident. Organs of primary interest, because of their high sensitivity or their potential for receiving large doses, are bone marrow, gastrointestinal tract, thyroid glands, lungs, skin, gonads, and eyes. Exposure of the fetus is also considered. Additional data and modeling techniques available since publication of the Reactor Safety Study were used to obtain models for morbidity and mortality

  5. Simultaneous ultrafiltration and diafiltration

    Directory of Open Access Journals (Sweden)

    Zavargo Zoltan Z.

    2002-01-01

    Full Text Available A model with simultaneous ultrafiltration and diafiltration, which includes the rejection coefficients, is presented in this study. Adding a diafiltration solution at a constant, lower rate than the filtrate rate results in a constant decrease of the solution volume in the tank. This enables the simultaneous attainment of the desired macrosolute concentration and microsulute dilution. The proposed model, based on incomplete macrosolute rejection and incomplete mi-crosolute permeation through a membrane, as well as constant permeate flux, is compared to the classical constant volume, diafiltration process. The obtained results show that less diafiltration volume is necessary with this process. Simultaneously, the duration of the process, for higher purification requirements, is shorter in this case.

  6. INTERSTITIAL LUNG-DISEASE AND MYOSITIS IN A PATIENT WITH SIMULTANEOUSLY OCCURRING SARCOIDOSIS AND SCLERODERMA

    NARCIS (Netherlands)

    GROEN, H; POSTMA, DS; KALLENBERG, CGM

    1993-01-01

    A patient initially presented with sarcoidosis in combination with myositis of sarcoid origin and Raynaud's phenomenon. During the course of his disease, he additionally developed scleroderma. Bronchoalveolar lavage, performed because of increase of interstitial markings in the presence of enlarged

  7. HP1 beta-dependent recruitment of UBF1 to irradiated chromatin occurs simultaneously with CPDs

    Czech Academy of Sciences Publication Activity Database

    Stixová, Lenka; Sehnalová, Petra; Legartová, Soňa; Suchánková, Jana; Hrušková, Tereza; Sorokin, D.V.; Matula, Pa.; Raška, I.; Kovařík, Aleš; Fulneček, Jaroslav; Bártová, Eva

    2014-01-01

    Roč. 7, DEC2014 (2014), s. 1-17 ISSN 1756-8935 R&D Projects: GA ČR(CZ) GAP302/10/1022; GA ČR(CZ) GBP302/12/G157; GA ČR(CZ) GA13-07822S Institutional support: RVO:68081707 Keywords : DNA-damage response * DNA repair * Irradiation Subject RIV: BO - Biophysics Impact factor: 5.333, year: 2014

  8. Simultaneous Occurence of Vulvar and Mammalian Lichen Sclerosus: A Case Report

    Directory of Open Access Journals (Sweden)

    Fazlı Demirtürk

    2006-08-01

    Lichen sclerosus et atrophicus confined to the vulva and mammalia is uncommon. We report the case of a 38-year old primer infertile women with a 10 year history of a white patch on her vulva and bilateral mammalia.

  9. Simultaneous occurrence of distinct symmetries in nuclei

    International Nuclear Information System (INIS)

    Leviatan, A.

    2016-01-01

    We show that distinct emergent symmetries, such as partial dynamical symmetry and quasi dynamical symmetry, can occur simultaneously in the same or different eigenstates of the Hamiltonian. Implications for nuclear spectroscopy in the rare-earth region and for first-order quantum phase transitions between spherical and deformed shapes, are considered. (paper)

  10. Politics Under Electronic Simultaneity

    Directory of Open Access Journals (Sweden)

    Valery P. Terin

    2014-01-01

    Full Text Available In contradistinction to the book and the other typographic products, the electronic media operates on a 24-hour-a-day basis evoking simultaneity as the guiding mode of perception and thinking for all those under its influence. The discovery of this fact manifested itself in the formation and development of the managerial technologies operating by means of the electronic information environment and following the principle of simultaneity in the first place. Thus, at the end of the 1960s already the election campaigns in the U.S.A. began to operate on the basis of the final cause as the guiding principle of the country's mass consciousness motivating to carry out each particular event as if already rejoicing at the victory. With this in mind, there emerged a problem of applying this approach with its enormous managerial potential elsewhere. To add, simultaneity as a norm of perception and thinking turned out to be increasingly important with the advent of the electrical telegraph and the press relying on its short disconnected messages instantaneously arriving from all parts of the world. All the other media, which emerged in the wake of this development, has served to fortify this mode of thought as governing in the electronic information environment. The potential of the electronically operating global managerial technologies is quickly growing. The article also deals with the information overload and pattern recognition problem understood in managerial terms as well as mythologization and demythologization processes as they are necessitated by the electronic media coverage worldwide.

  11. Simultaneous Intracranial and Spinal Subdural Hematoma: Two Case Reports

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Chung Dae; Song, Chang Joon; Lee, Jeong Eun; Choi, Seung Won [Chungnam National University, Daejeon (Korea, Republic of)

    2009-02-15

    Spinal subdural hematoma is a rare disease. Simultaneous intracranial and spinal subdural hematoma is extremely rare and only 14 such cases have been reported. We report here on two cases of simultaneous intracranial and spinal subdural hematoma that occurred following a fall-down head injury and intracranial surgery, and we discuss the pathogenesis of the disease.

  12. Simultaneous immunization against tuberculosis.

    Directory of Open Access Journals (Sweden)

    Elma Z Tchilian

    Full Text Available BCG, the only licensed vaccine against tuberculosis, provides some protection against disseminated disease in infants but has little effect on prevention of adult pulmonary disease. Newer parenteral immunization prime boost regimes may provide improved protection in experimental animal models but are unproven in man so that there remains a need for new and improved immunization strategies.Mice were immunized parenterally, intranasally or simultaneously by both routes with BCG or recombinant mycobacterial antigens plus appropriate adjuvants. They were challenged with Mycobacterium tuberculosis (Mtb and the kinetics of Mtb growth in the lungs measured. We show that simultaneous immunization (SIM of mice by the intranasal and parenteral routes is highly effective in increasing protection over parenteral BCG administration alone. Intranasal immunization induces local pulmonary immunity capable of inhibiting the growth of Mtb in the early phase (the first week of infection, while parenteral immunization has a later effect on Mtb growth. Importantly, these two effects are additive and do not depend on priming and boosting the immune response. The best SIM regimes reduce lung Mtb load by up to 2 logs more than BCG given by either route alone.These data establish SIM as a novel and highly effective immunization strategy for Mtb that could be carried out at a single clinic visit. The efficacy of SIM does not depend on priming and boosting an immune response, but SIM is complementary to prime boost strategies and might be combined with them.

  13. Simultaneous, Isolated Traumatic Bilateral Patella Fractures

    Science.gov (United States)

    Madi, Sandesh; Naik, Monappa; Rao, Sharath; Vijayan, Sandeep

    2016-01-01

    Introduction Isolated traumatic fractures of both Patellae, occurring at the same time, in an otherwise healthy person, are very rare. The Patella, as a subcutaneous and a cancellous bone, is vulnerable to injury. However, simultaneous injury to both Patellae without the involvement of any other bony injuries occurs infrequently, and only a few cases have been reported in the literature. Case Presentation We report a rare case of isolated, traumatic bilateral Patella fracture with unusual fracture patterns and briefly review the literature. Conclusions In simultaneous bilateral Patella fractures, good functional outcome can be expected following a stable surgical fixation and a structured rehabilitation regime. However, personality of the fracture determines salvage versus sacrifice of the Patella. PMID:27218047

  14. Simultaneous alcohol and cannabis expectancies predict simultaneous use

    Directory of Open Access Journals (Sweden)

    Earleywine Mitch

    2006-10-01

    Full Text Available Abstract Background Simultaneous use of alcohol and cannabis predicts increased negative consequences for users beyond individual or even concurrent use of the two drugs. Given the widespread use of the drugs and common simultaneous consumption, problems unique to simultaneous use may bear important implications for many substance users. Cognitive expectancies offer a template for future drug use behavior based on previous drug experiences, accurately predicting future use and problems. Studies reveal similar mechanisms underlying both alcohol and cannabis expectancies, but little research examines simultaneous expectancies for alcohol and cannabis use. Whereas research has demonstrated unique outcomes associated with simultaneous alcohol and cannabis use, this study hypothesized that unique cognitive expectancies may underlie simultaneous alcohol and cannabis use. Results: This study examined a sample of 2600 (66% male; 34% female Internet survey respondents solicited through advertisements with online cannabis-related organizations. The study employed known measures of drug use and expectancies, as well as a new measure of simultaneous drug use expectancies. Expectancies for simultaneous use of alcohol and cannabis predicted simultaneous use over and above expectancies for each drug individually. Discussion Simultaneous expectancies may provide meaningful information not available with individual drug expectancies. These findings bear potential implications on the assessment and treatment of substance abuse problems, as well as researcher conceptualizations of drug expectancies. Policies directing the treatment of substance abuse and its funding ought to give unique consideration to simultaneous drug use and its cognitive underlying factors.

  15. Note on Magnetism and Simultaneity

    Science.gov (United States)

    Huggins, Elisha

    2009-01-01

    The paper on "Magnetism and Simultaneity" by Adler provides an excellent new thought experiment involving the lack of simultaneity in Einstein's special relativity. Adler uses the lack of simultaneity rather than the Lorentz contraction to derive the formula for the magnetic force on a moving charged particle. Advantages of his derivation are that…

  16. Simultaneous Immersion Mirau Interferometry

    Science.gov (United States)

    Lyulko, Oleksandra

    acquisition challenging. This problem was resolved by integration of polarization optics into the optics of the attachment to enable simultaneous creation and spatial separation of two interferograms, which, combined with the background image, are used to reconstruct the intensity map of the specimen. Giving the name Simultaneous Immersion Mirau Interferometry to this approach, simultaneous acquisition of all interferograms per image has eliminated the issue of vibrations. The designed compound microscope attachment has been manufactured and tested; the system produces images of quality, sufficient to perform targeted cellular irradiation experiments.

  17. TENORM (Technologically Enhanced Naturally Occurring Radioactive Materials)

    Science.gov (United States)

    ... the beginning of time, naturally occurring. radionuclides or radioactive elements as they occur in nature, such as radium , uranium , thorium , potassium, and their radioactive decay products decay products The atoms formed and ...

  18. Simultaneous multislice (SMS) imaging techniques

    NARCIS (Netherlands)

    Barth, M.; Breuer, F.; Koopmans, P.J.; Norris, David Gordon; Poser, B.A.

    2016-01-01

    Simultaneous multislice imaging (SMS) using parallel image reconstruction has rapidly advanced to become a major imaging technique. The primary benefit is an acceleration in data acquisition that is equal to the number of simultaneously excited slices. Unlike in-plane parallel imaging this can have

  19. Method and apparatus for simultaneous spectroelectrochemical analysis

    Science.gov (United States)

    Chatterjee, Sayandev; Bryan, Samuel A; Schroll, Cynthia A; Heineman, William R

    2013-11-19

    An apparatus and method of simultaneous spectroelectrochemical analysis is disclosed. A transparent surface is provided. An analyte solution on the transparent surface is contacted with a working electrode and at least one other electrode. Light from a light source is focused on either a surface of the working electrode or the analyte solution. The light reflected from either the surface of the working electrode or the analyte solution is detected. The potential of the working electrode is adjusted, and spectroscopic changes of the analyte solution that occur with changes in thermodynamic potentials are monitored.

  20. Trichotillomania and co-occurring anxiety.

    Science.gov (United States)

    Grant, Jon E; Redden, Sarah A; Leppink, Eric W; Chamberlain, Samuel R

    2017-01-01

    Trichotillomania appears to be a fairly common disorder, with high rates of co-occurring anxiety disorders. Many individuals with trichotillomania also report that pulling worsens during periods of increased anxiety. Even with these clinical links to anxiety, little research has explored whether trichotillomania with co-occurring anxiety is a meaningful subtype. One hundred sixty-five adults with trichotillomania were examined on a variety of clinical measures including symptom severity, functioning, and comorbidity. Participants also underwent cognitive testing assessing motor inhibition and cognitive flexibility. Clinical features and cognitive functioning were compared between those with current co-occurring anxiety disorders (i.e. social anxiety, generalized anxiety disorder, panic disorder, and anxiety disorder NOS) (n=38) and those with no anxiety disorder (n=127). Participants with trichotillomania and co-occurring anxiety reported significantly worse hair pulling symptoms, were more likely to have co-occurring depression, and were more likely to have a first-degree relative with obsessive compulsive disorder. Those with anxiety disorders also exhibited significantly worse motor inhibitory performance on a task of motor inhibition (stop-signal task). This study suggests that anxiety disorders affect the clinical presentation of hair pulling behavior. Further research is needed to validate our findings and to consider whether treatments should be specially tailored differently for adults with trichotillomania who have co-occurring anxiety disorders, or more pronounced cognitive impairment. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Bulletin of International Simultaneous Observations

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The publication of the Bulletin of International Simultaneous Observations, began July 1, 1875, with daily maps added in 1877. It was published for distribution...

  2. Endogone lactiflua (Zygomycota, Endogonales occurs in Poland

    Directory of Open Access Journals (Sweden)

    Janusz Błaszkowski

    2011-01-01

    Full Text Available Morphological properties of sporocarps and spores of Endogone lactiflua (Zygomycota, Endogonales, a fungus for the first time found in Poland, are described and illustrated. Endogone lactiflua was wet sieved and decanted from a sample taken from the zone extending from the upper soil layer to rhizosphere of Pinus sylvestris growing in a forest dune in northern Poland. The recovered spores mainly occurred in large and compact sporocarps, although both small aggregates with a few spores and single zygosporangia of this fungus were also isolated. Endogone lactiflua is the fourth species of the genus Endogone found to occur in Poland. The distribution of the fungus in the world is also presented.

  3. Co-occurring mycotoxins in animal feeds

    African Journals Online (AJOL)

    STORAGESEVER

    2008-07-04

    Jul 4, 2008 ... Co-occurring mycotoxins in animal feeds. Phakamile T. Mngadi1, Roshini Govinden2, and Bharti Odhav1*. 1Department of Biotechnology, M.L. Sultan Campus, Durban University of Technology, P.O. Box 1334, Durban 4000,. South Africa. 2Medical Research Council, PO Box 70380, Over port 4091, ...

  4. Percieved functions of naturally occurring autobiographical memories

    DEFF Research Database (Denmark)

    Treebak, L. S.; Henriksen, J. R.; Lundhus, S.

    2005-01-01

    The main empirical reference on functions of autobiographical memories is still Hyman & Faries (1992) who used the cue-word-method and retrospective judgements. We used diaries to sample naturally occurring autobiographical memories and participants? perceived use of these. Results partly replicate...

  5. Chemical and Biological Significance of Naturally Occurring ...

    African Journals Online (AJOL)

    PROF HORSFALL

    Chemical and Biological Significance of Naturally Occurring Additives on. African Black Soap and its Performance. IKOTUN, A. ... attribute of the soap includes gentleness on the skin, rich lather, protection against skin disorders ... soap, the effects of its modifications with some commonly used natural products, as well as the ...

  6. A naturally occurring trap for antiprotons

    International Nuclear Information System (INIS)

    Eades, J.; Morita, N.; Ito, T.M.

    1993-05-01

    The phenomenon of delayed annihilation of antiprotons in helium is the first instance of a naturally occurring trap for antimatter in ordinary matter. Recent studies of this effect at CERN are summarized, and plans are described for laser excitation experiments to test its interpretation in terms of metastable exotic helium atom formation. (author)

  7. Formal synthesis of naturally occurring norephedrine

    Indian Academy of Sciences (India)

    A concise and simple synthesis of 1-hydroxy-phenethylamine derivatives has been achieved following classical organic transformations using commercially available chiral pools. The said derivatives were explored for the synthesis of naturally occurring bio-active small molecules. Formal synthesis of norephedrine, virolin ...

  8. Natural occurring radioactive substances. Vol. 1

    International Nuclear Information System (INIS)

    Emara, A.E.

    1996-01-01

    Naturally occurring radioactive substances produced by cosmic rays of those of terrestrial origin are surveyed. The different radioactive decay series are discussed. Special emphasis is given to the element radium as regards its properties and distribution in different environmental samples. The properties of naturally occurring k-40 and its distribution in different natural media are also outlined. Induced radionuclides which are formed as a result of the interaction of cosmic rays with the constituents of the atmosphere are mentioned. In this respect the intensity of natural background radiation and the dose at different locations and levels is surveyed. Some regions of exceptionally high radioactivity which result in high exposure rates are mentioned. Monazite deposits and water springs are mentioned in some detail. The Oklo phenomenon as a natural reactor is also discussed. 8 tabs

  9. Naturally Occuring Fish Poisons from Plants

    Science.gov (United States)

    Cannon, Jonathan G.; Burton, Robert A.; Wood, Steven G.; Owen, Noel L.

    2004-10-01

    Since prehistoric times, cultures throughout the world have used piscicidal (fish poisoning) plants for fishing. In recent times, scientists have identified many of the plant compounds responsible for killing the fish and have found that these compounds possess other important biological properties, such as insecticidal and anti-cancer activities. This article reviews some of the chemical research that has been performed on naturally occurring fish poisons, including plant sources, methods of use, toxicity, and mechanisms of action of piscicides.

  10. Clinical Characteristics of Stroke Occurring while Bathing.

    Science.gov (United States)

    Inamasu, Joji; Nakatsukasa, Masashi; Oshima, Takeo; Tomiyasu, Kazuhiro; Mayanagi, Keita; Imai, Akira

    2017-07-01

    Stroke can occur during any human activity. Although cardiac arrests or drowning accidents while bathing have been studied extensively, there are few studies focusing on stroke occurring while bathing. The objectives of this study were to evaluate the clinical characteristics of stroke occurring while bathing and the association between stroke and drowning accidents. Clinical data prospectively acquired between January 2011 and December 2015 on 1939 patients with stroke (1224 cerebral infarctions [CIs], 505 intracerebral hemorrhages [ICHs], and 210 subarachnoid hemorrhages [SAHs]) were reviewed to identify patients who sustained a stroke while bathing. The ratio of bathing-related strokes to strokes occurring during other activities was evaluated. Moreover, the demographics of these 2 groups were compared in each stroke type. Among the 1939 patients, 78 (CI, 32; ICH, 28; and SAH, 18) sustained a stroke while bathing. The ratio of bathing to other activities in the SAH group was the highest (8.6%), followed by the ICH group (5.5%), whereas that in the CI group was the lowest (2.6%). Regardless of stroke type, only a minority of patients were found to have collapsed inside the bathtub. The higher ratio of bathing in hemorrhagic strokes may indicate that there is a small risk of hemorrhagic stroke while bathing in vulnerable subjects. This retrospective study did not establish a causal relationship between bathing and stroke nor identify risk factors, which means that future prospective studies are warranted. The finding that the great majority of bathing-related stroke patients were found to have collapsed outside the bathtub suggests that the involvement of stroke in drowning accidents in the bathtub may be small. Copyright © 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  11. Diverticulitis occurs early after lung transplantation.

    Science.gov (United States)

    Larson, Eric S; Khalil, Hassan A; Lin, Anne Y; Russell, Marcia; Ardehali, Abbas; Ross, David; Yoo, James

    2014-08-01

    Lung transplantation recipients are at an increased risk for developing diverticulitis. However, the incidence and natural history of diverticulitis have not been well characterized. Our objective was to identify patient and transplant-related factors that may be associated with an increased risk of developing diverticulitis in this patient population. This is a retrospective single institution study. All patients who received a lung transplant between May 2008 and July 2013 were evaluated using an existing lung transplantation database. Patient-related factors, the incidence and timing of diverticulitis, and outcomes of medical and surgical management were measured. Of the 314 patients who received a lung transplant, 14 patients (4.5%) developed diverticulitis. All episodes (100%) of diverticulitis occurred within the first 2 y after transplantation. Eight patients (57%) required surgery with a mortality rate of 12.5%. Six patients (43%) were managed medically and did not require surgery with a mean follow-up period of 442 d. Diverticulitis is common after lung transplantation and occurs with a higher incidence compared with the general population. Diverticulitis occurs early in the posttransplant period, and the majority of patients require surgery. Patients who respond promptly to medical treatment may not require elective resection. A greater awareness of the risk of diverticulitis in the early posttransplant period may allow for earlier diagnosis and treatment. Copyright © 2014 Elsevier Inc. All rights reserved.

  12. Frequently Occurring Reconnection Jets from Sunspot Light Bridges

    Science.gov (United States)

    Tian, Hui; Yurchyshyn, Vasyl; Peter, Hardi; Solanki, Sami K.; Young, Peter R.; Ni, Lei; Cao, Wenda; Ji, Kaifan; Zhu, Yingjie; Zhang, Jingwen; Samanta, Tanmoy; Song, Yongliang; He, Jiansen; Wang, Linghua; Chen, Yajie

    2018-02-01

    Solid evidence of magnetic reconnection is rarely reported within sunspots, the darkest regions with the strongest magnetic fields and lowest temperatures in the solar atmosphere. Using the world’s largest solar telescope, the 1.6 m Goode Solar Telescope, we detect prevalent reconnection through frequently occurring fine-scale jets in the Hα line wings at light bridges, the bright lanes that may divide the dark sunspot core into multiple parts. Many jets have an inverted Y-shape, shown by models to be typical of reconnection in a unipolar field environment. Simultaneous spectral imaging data from the Interface Region Imaging Spectrograph show that the reconnection drives bidirectional flows up to 200 km s‑1, and that the weakly ionized plasma is heated by at least an order of magnitude up to ∼80,000 K. Such highly dynamic reconnection jets and efficient heating should be properly accounted for in future modeling efforts of sunspots. Our observations also reveal that the surge-like activity previously reported above light bridges in some chromospheric passbands such as the Hα core has two components: the ever-present short surges likely to be related to the upward leakage of magnetoacoustic waves from the photosphere, and the occasionally occurring long and fast surges that are obviously caused by the intermittent reconnection jets.

  13. Bilateral simultaneous spontaneous rupture of the quadriceps tendons

    African Journals Online (AJOL)

    simultaneous rupture of the quadriceps tendons. The injury occurs most often in elderly people and delay in the diagnosis is not uncommon. Early operative repair is recommended. By using a metal wire passing through a transverse hole in the superior pole of the patella and through the tendon proximal to the repair site, ...

  14. Envisioning Curriculum as Six Simultaneities

    Science.gov (United States)

    Hussain, Hanin; Conner, Lindsey; Mayo, Elaine

    2014-01-01

    This paper uses the discourse of complexity thinking to envision curriculum as six partial and coupled facets that exist simultaneously: curriculum as structure, curriculum as process, curriculum as content, curriculum as teaching, curriculum as learning and curriculum as activity. Such a curriculum is emergent and self-organising. It is emergent…

  15. SIMULTANEOUS SEPARATION AND PRECONCENTRATION OF ...

    African Journals Online (AJOL)

    In this work, a simple, rapid, selective, sensitive and economical method has been developed for the simultaneous separation and preconcentration of trace amounts of copper, nickel, cadmium, and zinc in aqueous medium using XAD-4 resins that were modified with 2-(5-bromo-2-pyridylazo)-5-diethylaminophenol ...

  16. Jerky Periods - Myoclonus Occurring Solely During Menses

    Directory of Open Access Journals (Sweden)

    Arthur W. Buijink

    2013-05-01

    Full Text Available Background: In this case report, we describe an unusual case of a patient with myoclonus only occurring during menses. Case Report: A 41-year-old female, known to have neurological sequelae after a car accident 1 year earlier, presented with myoclonic movements of the right arm and hand only during menses. Brain magnetic resonance imaging is compatible with head trauma. Electromyography shows brief irregular bursts with a duration of about 20 ms. Discussion: This appears to be the first description of myoclonus appearing only during menses. We suggest a cortical origin for myoclonus.

  17. Naturally occurring radionuclides and Earth sciences

    Directory of Open Access Journals (Sweden)

    G. Ferrara

    1997-06-01

    Full Text Available Naturally occurring radionuclides are used in Earth sciences for two fundamental purposes: age determination of rocks and minerals and studies of variation of the isotopic composition of radiogenic nuclides. The methodologies that are in use today allow us to determine ages spanning from the Earth's age to the late Quaternary. The variations of isotopic composition of radiogenic nuclides can be applied to problems of mantle evolution, magma genesis and characterization with respect to different geodynamic situations and can provide valuable information not obtainable by elemental geochemistry.

  18. Persulfate activation by naturally occurring trace minerals.

    Science.gov (United States)

    Teel, Amy L; Ahmad, Mushtaque; Watts, Richard J

    2011-11-30

    The potential for 13 naturally occurring minerals to mediate the decomposition of persulfate and generate a range of reactive oxygen species was investigated to provide fundamental information on activation mechanisms when persulfate is used for in situ chemical oxidation (ISCO). Only four of the minerals (cobaltite, ilmenite, pyrite, and siderite) promoted the decomposition of persulfate more rapidly than persulfate-deionized water control systems. The other nine minerals decomposed persulfate at the same rate or more slowly than the control systems. Mineral-mediated persulfate activation was conducted with the addition of one of three probe compounds to detect the generation of reactive oxygen species: anisole (sulfate+hydroxyl radical), nitrobenzene (hydroxyl radical), and hexachloroethane (reductants and nucleophiles). The reduced mineral pyrite promoted rapid generation of sulfate+hydroxyl radical. However, the remainder of the minerals provided minimal potential for the generation of reactive oxygen species. The results of this research demonstrate that the majority of naturally occurring trace minerals do not activate persulfate to generate reactive oxygen species, and other mechanisms of activation are necessary to promote contaminant destruction in the subsurface during persulfate ISCO. Copyright © 2011 Elsevier B.V. All rights reserved.

  19. Nipah virus entry can occur by macropinocytosis

    International Nuclear Information System (INIS)

    Pernet, Olivier; Pohl, Christine; Ainouze, Michelle; Kweder, Hasan; Buckland, Robin

    2009-01-01

    Nipah virus (NiV) is a zoonotic biosafety level 4 paramyxovirus that emerged recently in Asia with high mortality in man. NiV is a member, with Hendra virus (HeV), of the Henipavirus genus in the Paramyxoviridae family. Although NiV entry, like that of other paramyxoviruses, is believed to occur via pH-independent fusion with the host cell's plasma membrane we present evidence that entry can occur by an endocytic pathway. The NiV receptor ephrinB2 has receptor kinase activity and we find that ephrinB2's cytoplasmic domain is required for entry but is dispensable for post-entry viral spread. The mutation of a single tyrosine residue (Y304F) in ephrinB2's cytoplasmic tail abrogates NiV entry. Moreover, our results show that NiV entry is inhibited by constructions and drugs specific for the endocytic pathway of macropinocytosis. Our findings could potentially permit the rapid development of novel low-cost antiviral treatments not only for NiV but also HeV.

  20. Co-occurring psychiatric disorders and alcoholism.

    Science.gov (United States)

    Stephen Rich, J; Martin, Peter R

    2014-01-01

    Alcohol use disorder (AUD), a term that comprises both alcohol abuse and alcohol dependence, is a highly prevalent psychiatric disorder. Over 50% of treated AUD patients also suffer from other psychiatric disorder(s). Detailed study has revealed disorders across multiple psychiatric domains with rates of co-occurrence far greater than chance, suggesting a synergistic relationship. The basis of this synergy is explored along with its multiple forms, including behavioral and neurobiologic. Specific topics include the predisposition to both AUD and co-occurring psychopathology, the vulnerability to environmental risk factors that exacerbate these predispositions, and the nature of reinforcement in acute intoxication. Co-occurrence can also modify and exacerbate the neuroadaptations underpinning chronic dependence and relapse, the manifestations of acute and protracted withdrawal, emergence of medical and psychiatric complications, and ultimately the potential for relapse. The outcomes of co-occurrence as well as the unique impact it has on proper treatment are also discussed. Throughout, the significance of recognizing co-occurrence is emphasized since, both neurobiologically and clinically, the synergies between co-occurring disorders yield a result far more complex than a mere sum of the component disorders. © 2014 Elsevier B.V. All rights reserved.

  1. Leachability of naturally occurring radioactive materials

    International Nuclear Information System (INIS)

    Desideri, D.; Feduzi, L.; Meli, M.A.; Roselli, C.

    2006-01-01

    Naturally occurring radioactive materials (NORM) are present in the environment and can be concentrated by technical activities, particularly those involving natural resources. These NORM deposits are highly stable and very insoluble under environmental conditions at the earth's surface. However, reducing or oxidant conditions or pH changes may enable a fraction of naturally occurring radionuclides to eventually be released to the environment. Leachability of 210 Pb and 210 Po was determined in three samples coming from a refractories production plant (dust, sludge, finished product), in one dust sample from a steelwork and in one ash sample coming from an electric power station. A sequential extraction method consisting of five operationally-defined fractions was used. The average leaching potential observed in the samples from the refractory industry is very low (mean values: 5.8% for 210 Pb and 1.7% for 210 Po). The 210 Pb and 210 Po leachability increases for the ash sample coming from an electric power plant using carbon (17.8% for 210 Pb and 10.0% for 210 Po); for the dust sample coming from a steelwork, the percent soluble fraction is 41.1% for 210 Pb and 8.5% for 210 Po. For all samples the results obtained show that 210 Pb is slightly more soluble than 210 Po. (author)

  2. Simultaneous sorption of fluoride and arsenic ions (V) in a naturally occurring material modified with iron and aluminum

    International Nuclear Information System (INIS)

    Vazquez M, G.

    2016-01-01

    In this research, two materials, zeolite and pozzolans from the States of Oaxaca and Mexico, were used respectively, which were modified to evaluate their efficiencies to remove F and As(V) ions from solution and natural water. The materials were modified with iron and aluminum using an electrochemical cell, and with the hydroxides formed with iron and aluminum chloride solutions. The natural and modified materials were characterized by X-ray diffraction, scanning electron microscopy with energy X-ray disperse spectroscopy analysis, specific area and the point of zero charge (pHzpc). F- and As(V) adsorption properties of both materials were investigated. Experimental data on the sorption processes of F- ions by modified zeolite and pozzolans were adjusted to the kinetic models of pseudo-second-order (q e, 0408 mg /g K, 4.33 g / mg h) and Lagergen (q e, 0.807 mg/g K L, 1.83 1/min), respectively. Both materials showed the best fit to the Freundlich isotherm, Kf, 0.33 and 0.64 (mg/g) (L/mg) for pozzolans and zeolite respectively; suggesting a physical adsorption process on a heterogeneous material. Experimental adsorption capacities of pozzolans and modified zeolite for F ions were 0.36 and 0.83 mg/g respectively. The results of the kinetics of adsorption of As(V) were treated with the Largergren, pseudo-second-order and Elovich models; however the adsorption rate was high and consequently the rate constants could not be calculated. The isotherms data were fitted to the Freundlich model and the constants Kf were 6.24 and 11.15 (mg/g) (L/mg) for pozzolans and zeolite respectively. The thermodynamic parameters of the adsorption processes suggest endothermic adsorption for F- ions by both materials and for As(V) by the pozzolans. The free energy values ΔG indicate spontaneous processes and not spontaneous for F- ions by pozzolans. The adsorption of As (V) by the pozzolans presented an exothermic and spontaneous behavior. Finally, a study was performed in columns with the modified zeolite and natural water with F- (3.3 mg/L) and As (4.65 mg/L) ions. Experimental data of F- ions adsorption were fitted to the Bohart-Adams and Thomas models with 1.5 cm bed depth; the adsorption capacity was lower than the capacity obtained with F- solutions. The adsorption data for As was adjusted to Bohart-Adams model, the adsorption capacity was higher than the capacity obtained with As solutions. The modified zeolite with the electrochemical method was more efficient to remove F- and As ions than modified pozzolans with iron and aluminum hydroxides, therefore it can be used as an alternative to remove these ions from the water. (Author)

  3. Detection of Harmonic Occurring using Kalman Filtering

    DEFF Research Database (Denmark)

    Hussain, Dil Muhammad Akbar; Shoro, Ghulam Mustafa; Imran, Raja Muhammed

    2014-01-01

    As long as the load to a power system is linear which has been the case before 80's, typically no harmonics are produced. However, the modern power electronic equipment for controlled power consumption produces harmonic disturbances, these devices/equipment possess nonlinear voltage/current chara...... using Kalman filter. This may be very useful for example to quickly switching on certain filters based on the harmonic present. We are using a unique technique to detect the occurrence of harmonics......./current characteristic. These harmonics are not to be allowed to grow beyond a certain limit to avoid any grave consequence to the customer’s main supply. Filters can be implemented at the power source or utility location to eliminate these harmonics. In this paper we detect the instance at which these harmonics occur...

  4. Technologically enhanced naturally occurring radioactive materials.

    Science.gov (United States)

    Vearrier, David; Curtis, John A; Greenberg, Michael I

    2009-05-01

    Naturally occurring radioactive materials (NORM) are ubiquitous throughout the earth's crust. Human manipulation of NORM for economic ends, such as mining, ore processing, fossil fuel extraction, and commercial aviation, may lead to what is known as "technologically enhanced naturally occurring radioactive materials," often called TENORM. The existence of TENORM results in an increased risk for human exposure to radioactivity. Workers in TENORM-producing industries may be occupationally exposed to ionizing radiation. TENORM industries may release significant amounts of radioactive material into the environment resulting in the potential for widespread exposure to ionizing radiation. These industries include mining, phosphate processing, metal ore processing, heavy mineral sand processing, titanium pigment production, fossil fuel extraction and combustion, manufacture of building materials, thorium compounds, aviation, and scrap metal processing. A search of the PubMed database ( www.pubmed.com ) and Ovid Medline database ( ovidsp.tx.ovid.com ) was performed using a variety of search terms including NORM, TENORM, and occupational radiation exposure. A total of 133 articles were identified, retrieved, and reviewed. Seventy-three peer-reviewed articles were chosen to be cited in this review. A number of studies have evaluated the extent of ionizing radiation exposure both among workers and the general public due to TENORM. Quantification of radiation exposure is limited because of modeling constraints. In some occupational settings, an increased risk of cancer has been reported and postulated to be secondary to exposure to TENORM, though these reports have not been validated using toxicological principles. NORM and TENORM have the potential to cause important human health effects. It is important that these adverse health effects are evaluated using the basic principles of toxicology, including the magnitude and type of exposure, as well as threshold and dose response.

  5. Model Persamaan Simultan pada Analisis Hubungan Kemiskian dan PDRB

    Directory of Open Access Journals (Sweden)

    Rokhana Dwi Bekti

    2014-12-01

    Full Text Available Simultaneous model is a model for some equation which have simultaneous relationships. It was often found in econometrics, such as the relationship between Gross Domestic Regional Product (GDRP and poverty. GDP is a common indicator that can be used to determine the economic growth occurred in region. Meanwhile, poverty is one of the indicators to measure the society welfare. Information about these relathionships were important to perform the relathionsips between GDP and poverty. So this research conducted an analysis to obtain simultaneous models between GDRP and poverty. Estimation of the parameters used is Two-Stage Least Squares Estimation (2SLS. The data used are 33 provinces in Indonesia at 2010. By α = 5%, it was conclude that variable which significant effect on GDRP is poverty, export, and import. Meanwhile, the variables that significantly affect poverty are population. The simultaneous model (α = 5% also conclude that there is no simultaneous relationship between GDRP and poverty. However, with α = 25%, there is a simultaneous relationship between GDRP and poverty.

  6. Simultaneous bilateral patellar tendon rupture ?

    OpenAIRE

    Moura, Diogo Lino; Marques, Jos? Pedro; Lucas, Francisco Manuel; Fonseca, Fernando Pereira

    2016-01-01

    Bilateral patellar tendon rupture is a rare entity, often associated with systemic diseases and patellar tendinopathy. The authors report a rare case of a 34-year-old man with simultaneous bilateral rupture of the patellar tendon caused by minor trauma. The patient is a retired basketball player with no past complaints of chronic knee pain and a history of steroid use. Surgical management consisted in primary end-to-end tendon repair protected temporarily with cerclage wiring, followed by a s...

  7. Introduction to naturally occurring radioactive material

    Energy Technology Data Exchange (ETDEWEB)

    Egidi, P.

    1997-08-01

    Naturally occurring radioactive material (NORM) is everywhere; we are exposed to it every day. It is found in our bodies, the food we eat, the places where we live and work, and in products we use. We are also bathed in a sea of natural radiation coming from the sun and deep space. Living systems have adapted to these levels of radiation and radioactivity. But some industrial practices involving natural resources concentrate these radionuclides to a degree that they may pose risk to humans and the environment if they are not controlled. Other activities, such as flying at high altitudes, expose us to elevated levels of NORM. This session will concentrate on diffuse sources of technologically-enhanced (TE) NORM, which are generally large-volume, low-activity waste streams produced by industries such as mineral mining, ore benefication, production of phosphate Fertilizers, water treatment and purification, and oil and gas production. The majority of radionuclides in TENORM are found in the uranium and thorium decay chains. Radium and its subsequent decay products (radon) are the principal radionuclides used in characterizing the redistribution of TENORM in the environment by human activity. We will briefly review other radionuclides occurring in nature (potassium and rubidium) that contribute primarily to background doses. TENORM is found in many waste streams; for example, scrap metal, sludges, slags, fluids, and is being discovered in industries traditionally not thought of as affected by radionuclide contamination. Not only the forms and volumes, but the levels of radioactivity in TENORM vary. Current discussions about the validity of the linear no dose threshold theory are central to the TENORM issue. TENORM is not regulated by the Atomic Energy Act or other Federal regulations. Control and regulation of TENORM is not consistent from industry to industry nor from state to state. Proposed regulations are moving from concentration-based standards to dose

  8. Introduction to naturally occurring radioactive material

    International Nuclear Information System (INIS)

    Egidi, P.

    1997-01-01

    Naturally occurring radioactive material (NORM) is everywhere; we are exposed to it every day. It is found in our bodies, the food we eat, the places where we live and work, and in products we use. Some industrial practices involving natural resources concentrate these radionuclides to a degree that they may pose risk to humans and the environment if they are not controlled. This session will concentrate on diffuse sources of technologically-enhanced (TE) NORM, which are generally large-volume, low-activity waste streams produced by industries such as mineral mining, ore benefication, production of phosphate Fertilizers, water treatment and purification, and oil and gas production. The majority of radionuclides in TENORM are found in the uranium and thorium decay chains. Radium and its subsequent decay products (radon) are the principal radionuclides used in characterizing the redistribution of TENORM in the environment by human activity. We will briefly review other radionuclides occurring in nature (potassium and rubidium) that contribute primarily to background doses. TENORM is found in many waste streams; for example, scrap metal, sludges, slags, fluids, and is being discovered in industries traditionally not thought of as affected by radionuclide contamination. Not only the forms and volumes, but the levels of radioactivity in TENORM vary. Current discussions about the validity of the linear no dose threshold theory are central to the TENORM issue. TENORM is not regulated by the Atomic Energy Act or other Federal regulations. Control and regulation of TENORM is not consistent from industry to industry nor from state to state. Proposed regulations are moving from concentration-based standards to dose-based standards. So when is TENORM a problem? Where is it a problem? That depends on when, where, and whom you talk to exclamation point We will start by reviewing background radioactivity, then we will proceed to the geology, mobility, and variability of these

  9. Phagocytosis occurs in Acanthamoeba castellanii after electroporation.

    Science.gov (United States)

    Dybowska, U; Krawczynska, W; Sobota, A

    1996-09-01

    Acanthamoeba cells treated with an electric discharge were porated and their cytoplasm became accessible to exogenous molecules. Over a broad range of electric field densities low molecular weight markers (trypan blue, ruthenium red), normally unable to penetrate a plasma membrane, gained access to cytoplasm of 80-90% of the cells. Macromolecules (albumin-FITC and IgG-FITC) penetrated into 63-86% of the cells when electroporation was carried out over the range of 1500V/25 microF-400V/250 microF. Pulse labeling with fluorescent markers evidenced that even 3 hrs. after an electric pulse the plasma membrane was still permeable to exogenous fluorescent probes. Following this stage, the pores were gradually closed. The cells electroporated at 400 V/250 microF were able to ingest yeast particles. The uptake of the particles seems to be an active process since it was inhibited by azide and phalloidin. Therefore, the electroporation of Acanthamoeba makes possible the introduction of macromolecules into the cells and subsequent analysis of their effect on active motile processes such as phagocytosis. This should greatly facilitate characterization of the mechanisms by which such processes do occur.

  10. Uranium occurence in California near Bucaramanga (Columbia)

    International Nuclear Information System (INIS)

    Heider Polania, J.

    1980-01-01

    The mining district of California, Bucaramanga, is on the west side of the Cordillera Oriental in the Santander massif region. The oldest rocks of the area form a complex of metamorphites and migmatites of the predevonic age. Amphibolite various types of paragneiss and orthogneiss are represented. Several stages of metamorphism can be documented in some rocks, as well as double anatexis. Triassic to jurassic quarz diorites and leukogranites show wide distribution. Porphyric rocks of granodioritic to granitic composition, to which the uranium mineralization is mainly bonded, intruded into the sediments of the lower cretaceous. Atomic absorption spectral analyses were carried out for the elements Cu, Zn and Li, as well as the uranium contents of some samples using fluorimetry. Uranium is primarily bonded to pitch blende and coffinite. The latter mostly occur in fine distribution grown in quarz and belong to the most recent mineralization phase. Autunite, meta-autunite, torbernite, meta-torbernite, zeunerite, meta-zeunerite and meta uranocircite detected as secondary uranium minerals. (orig./HP) [de

  11. Naturally occurring flavonoids against human norovirus surrogates.

    Science.gov (United States)

    Su, Xiaowei; D'Souza, Doris H

    2013-06-01

    Naturally occurring plant-derived flavonoids are reported to have antibacterial, antiviral, and pharmacological activities. The objectives of this study were to determine the antiviral effects of four flavonoids (myricetin, L-epicatechin, tangeretin, and naringenin) on the infectivity of food borne norovirus surrogates after 2 h at 37 °C. The lab-culturable surrogates, feline calicivirus (FCV-F9) at titers of ~7 log₁₀ PFU/ml (high titer) or ~5 log₁₀ PFU/ml (low titer) and murine norovirus (MNV-1) at ~5 log₁₀ PFU/ml, were mixed with equal volumes of myricetin, L-epicatechin, tangeretin, or naringenin at concentrations of 0.5 or 1 mM, and incubated for 2 h at 37 °C. Treatments of viruses were neutralized in cell culture medium containing 10 % heat-inactivated fetal bovine serum, serially diluted, and plaque assayed. Each treatment was replicated thrice and assayed in duplicate. FCV-F9 (low titer) was not found to be reduced by tangeretin or naringenin, but was reduced to undetectable levels by myricetin at both concentrations. Low titer FCV-F9 was also decreased by 1.40 log₁₀ PFU/ml with L-epicatechin at 0.5 mM. FCV-F9 at high titers was decreased by 3.17 and 0.72 log₁₀ PFU/ml with myricetin and L-epicatechin at 0.5 mM, and 1.73 log10 PFU/ml with myricetin at 0.25 mM, respectively. However, MNV-1 showed no significant inactivation by the four tested treatments. The antiviral effects of the tested flavonoids are dependent on the virus type, titer, and dose. Further research will focus on understanding the antiviral mechanism of myricetin and L-epicatechin.

  12. Differential dormancy of co-occurring copepods

    Science.gov (United States)

    Ohman, Mark D.; Drits, Aleksandr V.; Elizabeth Clarke, M.; Plourde, Stéphane

    1998-08-01

    Four species of planktonic calanoid copepods that co-occur in the California Current System ( Eucalanus californicus Johnson, Rhincalanus nasutus Giesbrecht, Calanus pacificus californicus Brodsky, and Metridia pacifica Brodsky) were investigated for evidence of seasonal dormancy in the San Diego Trough. Indices used to differentiate actively growing from dormant animals included developmental stage structure and vertical distribution; activity of aerobic metabolic enzymes (Citrate Synthase and the Electron Transfer System complex); investment in depot lipids (wax esters and triacylglycerols); in situ grazing activity from gut fluorescence; and egg production rates in simulated in situ conditions. None of the 4 species exhibited a canonical calanoid pattern of winter dormancy - i.e., synchronous developmental arrest as copepodid stage V, descent into deep waters, reduced metabolism, and lack of winter reproduction. Instead, Calanus pacificus californicus has a biphasic life history in this region, with an actively reproducing segment of the population in surface waters overlying a deep dormant segment in winter. Eucalanus californicus is dormant as both adult females and copepodid V's, although winter females respond relatively rapidly to elevated food and temperature conditions; they begin feeding and producing eggs within 2-3 days. Rhincalanus nasutus appears to enter dormancy as adult females, although the evidence is equivocal. Metridia pacifica shows no evidence of dormancy, with sustained active feeding, diel vertical migration behavior, and elevated activity of metabolic enzymes in December as well as in June. The four species also differ markedly in water content, classes of storage lipids, and specific activity of Citrate Synthase. These results suggest that copepod dormancy traits and structural composition reflect diverse adaptations to regional environmental conditions rather than a uniform, canonical series of traits that remain invariant among taxa

  13. Simultaneous Onset of Ischemic and Hemorrhagic Stroke Due To Intracranial Artery Dissection

    OpenAIRE

    Kim, Jong-Hoon; Jung, Young-Jin; Chang, Chul-Hoon

    2017-01-01

    Intracranial dissections commonly present as ischemic stroke and as hemorrhagic stroke. In general, while either ischemic stroke or hemorrhagic stroke may develop, the simultaneous onset of both may also occasionally occur. In this report, we present a case of simultaneous development of ischemic stroke and hemorrhagic stroke due to an intracranial artery dissection.

  14. Sundew adhesive: a naturally occurring hydrogel.

    Science.gov (United States)

    Huang, Yujian; Wang, Yongzhong; Sun, Leming; Agrawal, Richa; Zhang, Mingjun

    2015-06-06

    Bioadhesives have drawn increasing interest in recent years, owing to their eco-friendly, biocompatible and biodegradable nature. As a typical bioadhesive, sticky exudate observed on the stalked glands of sundew plants aids in the capture of insects and this viscoelastic adhesive has triggered extensive interests in revealing the implied adhesion mechanisms. Despite the significant progress that has been made, the structural traits of the sundew adhesive, especially the morphological characteristics in nanoscale, which may give rise to the viscous and elastic properties of this mucilage, remain unclear. Here, we show that the sundew adhesive is a naturally occurring hydrogel, consisting of nano-network architectures assembled with polysaccharides. The assembly process of the polysaccharides in this hydrogel is proposed to be driven by electrostatic interactions mediated with divalent cations. Negatively charged nanoparticles, with an average diameter of 231.9 ± 14.8 nm, are also obtained from this hydrogel and these nanoparticles are presumed to exert vital roles in the assembly of the nano-networks. Further characterization via atomic force microscopy indicates that the stretching deformation of the sundew adhesive is associated with the flexibility of its fibrous architectures. It is also observed that the adhesion strength of the sundew adhesive is susceptible to low temperatures. Both elasticity and adhesion strength of the sundew adhesive reduce in response to lowering the ambient temperature. The feasibility of applying sundew adhesive for tissue engineering is subsequently explored in this study. Results show that the fibrous scaffolds obtained from sundew adhesive are capable of increasing the adhesion of multiple types of cells, including fibroblast cells and smooth muscle cells, a property that results from the enhanced adsorption of serum proteins. In addition, in light of the weak cytotoxic activity exhibited by these scaffolds towards a variety of

  15. Simultaneous homicide-suicide: a case report of double drowning.

    Science.gov (United States)

    Melez, İpek Esen; Avşar, Abdullah; Başpınar, Bünyamin; Melez, Deniz Oğuzhan; Şahin, Fatih; Özdeş, Taşkın

    2014-09-01

    Homicide-suicide is a tragic phenomenon which typically does not result in a criminal charge or trial. However, correct diagnosis and classification of homicide-suicide cases are important to determine the perpetrators and dynamics of each category properly. The deaths in the homicide-suicide acts can be divided into two categories with respect to the number of involved individuals: dyadic deaths and triple or multiple deaths. These two categories can also be divided into two subgroups according to the chronology of the incidents: simultaneous deaths and consecutive deaths. Herein, a simultaneous homicide-suicide case of a father and daughter where both deaths occurred through drowning which was not found in the selected literature review and where the victim was a child is presented. The article aims to clarify the term discrepancies about multiple death cases in the literature and to discuss the pathological and psychosocial characteristics of the simultaneous dyadic death cases. © 2014 American Academy of Forensic Sciences.

  16. Simultaneous tracking and activity recognition

    DEFF Research Database (Denmark)

    Manfredotti, Cristina Elena; Fleet, David J.; Hamilton, Howard J.

    2011-01-01

    Many tracking problems involve several distinct objects interacting with each other. We develop a framework that takes into account interactions between objects allowing the recognition of complex activities. In contrast to classic approaches that consider distinct phases of tracking and activity...... recognition, our framework performs these two tasks simultaneously. In particular, we adopt a Bayesian standpoint where the system maintains a joint distribution of the positions, the interactions and the possible activities. This turns out to be advantegeous, as information about the ongoing activities can...

  17. Simultaneous bilateral patellar tendon rupture.

    Science.gov (United States)

    Moura, Diogo Lino; Marques, José Pedro; Lucas, Francisco Manuel; Fonseca, Fernando Pereira

    2017-01-01

    Bilateral patellar tendon rupture is a rare entity, often associated with systemic diseases and patellar tendinopathy. The authors report a rare case of a 34-year-old man with simultaneous bilateral rupture of the patellar tendon caused by minor trauma. The patient is a retired basketball player with no past complaints of chronic knee pain and a history of steroid use. Surgical management consisted in primary end-to-end tendon repair protected temporarily with cerclage wiring, followed by a short immobilization period and intensive rehabilitation program. Five months after surgery, the patient was able to fully participate in sport activities.

  18. Simultaneous bilateral patellar tendon rupture

    Directory of Open Access Journals (Sweden)

    Diogo Lino Moura

    Full Text Available ABSTRACT Bilateral patellar tendon rupture is a rare entity, often associated with systemic diseases and patellar tendinopathy. The authors report a rare case of a 34-year-old man with simultaneous bilateral rupture of the patellar tendon caused by minor trauma. The patient is a retired basketball player with no past complaints of chronic knee pain and a history of steroid use. Surgical management consisted in primary end-to-end tendon repair protected temporarily with cerclage wiring, followed by a short immobilization period and intensive rehabilitation program. Five months after surgery, the patient was able to fully participate in sport activities.

  19. Simultaneous beta and gamma spectroscopy

    Science.gov (United States)

    Farsoni, Abdollah T.; Hamby, David M.

    2010-03-23

    A phoswich radiation detector for simultaneous spectroscopy of beta rays and gamma rays includes three scintillators with different decay time characteristics. Two of the three scintillators are used for beta detection and the third scintillator is used for gamma detection. A pulse induced by an interaction of radiation with the detector is digitally analyzed to classify the type of event as beta, gamma, or unknown. A pulse is classified as a beta event if the pulse originated from just the first scintillator alone or from just the first and the second scintillator. A pulse from just the third scintillator is recorded as gamma event. Other pulses are rejected as unknown events.

  20. Simultaneous multislice (SMS) imaging techniques.

    Science.gov (United States)

    Barth, Markus; Breuer, Felix; Koopmans, Peter J; Norris, David G; Poser, Benedikt A

    2016-01-01

    Simultaneous multislice imaging (SMS) using parallel image reconstruction has rapidly advanced to become a major imaging technique. The primary benefit is an acceleration in data acquisition that is equal to the number of simultaneously excited slices. Unlike in-plane parallel imaging this can have only a marginal intrinsic signal-to-noise ratio penalty, and the full acceleration is attainable at fixed echo time, as is required for many echo planar imaging applications. Furthermore, for some implementations SMS techniques can reduce radiofrequency (RF) power deposition. In this review the current state of the art of SMS imaging is presented. In the Introduction, a historical overview is given of the history of SMS excitation in MRI. The following section on RF pulses gives both the theoretical background and practical application. The section on encoding and reconstruction shows how the collapsed multislice images can be disentangled by means of the transmitter pulse phase, gradient pulses, and most importantly using multichannel receiver coils. The relationship between classic parallel imaging techniques and SMS reconstruction methods is explored. The subsequent section describes the practical implementation, including the acquisition of reference data, and slice cross-talk. Published applications of SMS imaging are then reviewed, and the article concludes with an outlook and perspective of SMS imaging. © 2015 Wiley Periodicals, Inc.

  1. Simultaneous bilateral primary spontaneous pneumothorax

    Directory of Open Access Journals (Sweden)

    Arife Zeybek

    2014-04-01

    Full Text Available Simultaneous bilateral primary pneumothorax is a very rare (1.6 / 100,000 and life-threatening condition. Clinical presentation may vary from mild dyspnea to tension pneumothorax. It may be milder particularly in younger patients, but more severe in patients with advanced age, and tube thoracostomy is a life preserver in the latter group. Since mortality and recurrence rates following tube thoracostomy are high, endoscopic approaches to bilateral hemithorax have been reported in literature. Apical wedge resection and pleural procedures are recommended in video thoracoscopy or mini thoracotomy even if no bulla and/or bleb are detected. Bilateral surgical interventions and additional pleural procedures are associated with increased rate of post-operative complications and longer postoperative hospital-stays. As a first-line approach, the surgical method toward any side of lung with air leakage following a previous tube thoracostomy is considered less invasive, especially in younger patients. Here, we present a case of simultaneous bilateral primary spontaneous pneumothorax (SBPSP in a 21-year old male with no history of smoking and chronic pulmonary disease. A unilateral surgical intervention was performed, and no recurrence was observed during 5-year follow up.

  2. Uranium occurence in nature: Geophysical prospecting, and its occurence in Syria

    International Nuclear Information System (INIS)

    Al-Haj Rasheed, Zaki

    1985-01-01

    A general idea about naturaly occured uranium minerals such as uranite, pechblende, carnotite, coffinit, and bronnerit is given. At the same time, different geophysical methods and detecting devices applied for uranium exploration have been demonstrated. Investigations and studies carried out in Syria point to a uranium content of 100 ppm in the exploited Syrian phosphorite. 1 fig., 1 tab

  3. Simultaneous bilateral laser in situ keratomileusis: safety and efficacy.

    Science.gov (United States)

    Gimbel, H V; van Westenbrugge, J A; Penno, E E; Ferensowicz, M; Feinerman, G A; Chen, R

    1999-08-01

    To compare the safety and efficacy of simultaneous bilateral to sequential bilateral laser in situ keratomileusis (LASIK) surgery for the correction of myopia. Retrospective, nonrandomized, comparative trial. A total of 2142 consecutive simultaneous and sequential bilateral myopic LASIK surgery eyes operated from March 1996 through June 1998 for the correction of myopia were reviewed. Two surgeons (HVG and JAV) performed myopic LASIK using the Nidek EC-5000 excimer laser and either the Chiron Automated Corneal Shaper or the Bausch & Lomb Hansatome microkeratome. The incidence of intra- or perioperative complications for sequential and simultaneous bilateral LASIK for myopia was recorded. Refractive and visual outcomes at 3 to 6 months postoperative were analyzed. Deviations from targeted spherical equivalent (SE), uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), and retreatment rates are reported. Laser in situ keratomileusis was performed on the first eye of 1853 patients scheduled for simultaneous bilateral myopic LASIK. Of these, 28 (1.5%) first eyes had intraoperative or perioperative complications. The second eye surgery was cancelled in 11 cases, and 1842 second eyes completed simultaneous surgery; 13 (0.7%) intraoperative or perioperative complications occurred. Of these 41 complications in simultaneous cases, 1 eye lost 1 line of BCVA at 6 months follow-up. Two hundred eighty-nine patients were scheduled for sequential bilateral myopic LASIK. Five (1.8%) first eyes of the sequential cases had intraoperative complications compared with four (1.4%) sequential second eyes. There was no loss of BCVA in any sequential bilateral case with complications at a minimum at 6 months follow-up. There was no statistically significant difference between intra- and perioperative complication rates comparing simultaneous to sequential bilateral LASIK. Three to 6 months postoperative visual and refractive data were reviewed; except when comparing

  4. On Teaching the Lack of Simultaneity

    Science.gov (United States)

    Huggins, Elisha R.

    1975-01-01

    Describes a lecture demonstration that has been effective in teaching the concept of the lack of simultaneity in introductory physics courses. The demonstration experiment can be used for studying the relationship between simultaneity and causality and as a conceptual device for analyzing the lack of simultaneity in special relativity thought…

  5. Simultaneous Occurrence of Dens Invaginatus and Fusion

    Directory of Open Access Journals (Sweden)

    Amit Mhapuskar

    2013-01-01

    Full Text Available Although Dens invaginatus and fusion are well-known and well established dental anomalies, they are rarely seen in supernumerary teeth. In this article, simultaneous occurrence of Dens invaginatus and fusion between maxillary lateral incisor and a supernumerary tooth is described. Dens invaginatus is clinically significant due to the possibility of the pulpal involvement; pulpitis, necrotic pulps and chronic periapical lesions are often associated with this anomaly without clinical symptoms. Fusion has a negative impact on the aesthetics, especially when it occurs in maxillary anterior teeth. It is difficult to clinically make differential diagnosis between fused teeth and geminated teeth, especially when these anomalies take place together with hypodontia or supernumerary tooth. It has been found that sequel of such teeth may result in delayed eruption, ectopic eruption or even impaction of permanent teeth; hence proper diagnosis by clinical and radiographic methods and intervention at appropriate time is of paramount importance. The accurate knowledge of variations in morphology of tooth and pulp cavity greatly assists the dentist in planning successful treatment options.

  6. Simultaneous analysis of uranium and nitrate

    Energy Technology Data Exchange (ETDEWEB)

    Bostick, D.T.

    1978-04-01

    A direct spectrophotometric method has been developed for the determination of 20 to 200 g/l of uranium in the presence of 3 to 5 M nitric acid. A dual-wavelength analysis is used to eliminate the enhancing effect of nitrate ion on the uranium visible spectra. The precision and accuracy of the simultaneous analysis of uranium and nitrate were compared using combinations of the four uranium wavelength maxima, occurring at 426, 416, 403 and 359 nm. Calculations based on 426 and 416 nm data yielded the most accurate results. The calculated relative standard deviation of uranium and nitrate concentrations was 5.4 percent and 15.5 percent, respectively. The photometric procedure is slightly affected by temperature; an increase of one degree centigrade results in a 0.2 g/l overestimation of uranium concentration. Because the method is non-destructive, it is directly applicable to the continuous in-line analysis of dissolved uranium in aqueous fuel reprocessing streams.

  7. Concepts of Simultaneity From Antiquity to Einstein and beyond

    Energy Technology Data Exchange (ETDEWEB)

    Muller, F A [Dept. of Physics and Astronomy, Institute for the History and Foundations of Science, Utrecht University, Utrecht University P.O Box 80125, 3508 TC Utrecht (Netherlands)

    2007-10-05

    Concepts of Simultaneity (henceforth: Simultaneity) is Jammer's historical monograph dedicated to the development of a single concept in physics. Jammer's idea to write a history of concepts of simultaneity proves to be a wonderful idea: it makes Simultaneity literally unique in its kind and it provides a new perspective from which to look at the historical development of concepts of time, about which much has already been written. Anyone who believes that Einstein was the first person on planet Earth to reflect on how to establish whether two distant events have occurred at the same time, i.e. simultaneously, will stop believing this after having read chapters 2 and 3 of Simultaneity (chapter 1 consists of terminological preliminaries), which deal with Antiquity and the Middle Ages, respectively. For example, Augustine of Hippo anticipated, in his Confessions (397 C.E.), nothing less than the method to determine the simultaneity of distant events that we associate with Einstein. Augustine set out to criticise the heresy of astrology. He considered two infants being born simultaneously in distant places. According to the doctrines of astrology they should lead very similar lives, because they are born under the same constellation of the stars. Yet one infant, Augustine imagined, is the child of a poor maid servant whereas the other is the child of a rich lady, so that they would almost certainly lead very different lives. How to know whether the infants are born simultaneously? Augustine proposed to dispatch, at the moment of birth, two messengers who run equally fast from the houses were the babies were born (whether they do run equally fast can be ascertained by using only local simultaneity judgments); the messengers should run towards each other in order to see whether they meet 'at equal distance from either house' (p. 49). If so, the infants were born simultaneously. Of course, this will not be very accurate, but that is not the point. The

  8. Can neural machine translation do simultaneous translation?

    OpenAIRE

    Cho, Kyunghyun; Esipova, Masha

    2016-01-01

    We investigate the potential of attention-based neural machine translation in simultaneous translation. We introduce a novel decoding algorithm, called simultaneous greedy decoding, that allows an existing neural machine translation model to begin translating before a full source sentence is received. This approach is unique from previous works on simultaneous translation in that segmentation and translation are done jointly to maximize the translation quality and that translating each segmen...

  9. Pulmonary tuberculosis and lung cancer: simultaneous and sequential occurrence

    Directory of Open Access Journals (Sweden)

    Denise Rossato Silva

    2013-06-01

    Full Text Available OBJECTIVE: Lung cancer (LC is the leading cause of cancer-related death and represents a major public health problem worldwide. Another major cause of morbidity and mortality, especially in developing countries, is tuberculosis. The simultaneous or sequential occurrence of pulmonary tuberculosis and LC in the same patient has been reported in various case series and case-control studies. The objective of this study was to describe the characteristics of patients developing tuberculosis and LC, either simultaneously or sequentially. METHODS: This was a cross-sectional study based on the review of medical charts. RESULTS: The study involved 24 patients diagnosed with tuberculosis and LC between 2009 and 2012. The diagnoses of tuberculosis and LC occurred simultaneously in 10 patients, whereas tuberculosis was diagnosed prior to LC in 14. The median time between the two diagnoses was 5 years (interquartile range: 1-30 years. Fourteen patients (58.3% were male, 20 (83.3% were White, and 22 (91.7% were smokers or former smokers. The most common histological type was adenocarcinoma, identified in 14 cases (58.3%, followed by epidermoid carcinoma, identified in 6 (25.0%. Seven patients (29.2% presented with distant metastases at diagnosis; of those 7 patients, 5 (71% were diagnosed with LC and tuberculosis simultaneously. CONCLUSIONS: In the present study, most of the patients with tuberculosis and LC were smokers or former smokers, and tuberculosis was diagnosed either before or simultaneously with LC. Non-small cell lung cancer, especially adenocarcinoma, was the most common histological type.

  10. Striatal and Hippocampal Entropy and Recognition Signals in Category Learning: Simultaneous Processes Revealed by Model-Based fMRI

    Science.gov (United States)

    Davis, Tyler; Love, Bradley C.; Preston, Alison R.

    2012-01-01

    Category learning is a complex phenomenon that engages multiple cognitive processes, many of which occur simultaneously and unfold dynamically over time. For example, as people encounter objects in the world, they simultaneously engage processes to determine their fit with current knowledge structures, gather new information about the objects, and…

  11. Simultaneity as an Invariant Equivalence Relation

    Science.gov (United States)

    Mamone-Capria, Marco

    2012-11-01

    This paper deals with the concept of simultaneity in classical and relativistic physics as construed in terms of group-invariant equivalence relations. A full examination of Newton, Galilei and Poincaré invariant equivalence relations in ℝ4 is presented, which provides alternative proofs, additions and occasionally corrections of results in the literature, including Malament's theorem and some of its variants. It is argued that the interpretation of simultaneity as an invariant equivalence relation, although interesting for its own sake, does not cut in the debate concerning the conventionality of simultaneity in special relativity.

  12. Current status of co-occurring mood and substance use disorders: a new therapeutic target.

    Science.gov (United States)

    Pettinati, Helen M; O'Brien, Charles P; Dundon, William D

    2013-01-01

    Mood and substance use disorders commonly co-occur, yet there is little evidence-based research to guide the pharmacologic management of these comorbid disorders. The authors review the existing empirical findings, some of which may call into question current clinical pharmacotherapy practices for treating co-occurring mood and substance use disorders. The authors also highlight knowledge gaps that can serve as a basis for future research. The specific mood disorders reviewed are bipolar and major depressive disorders (either one co-occurring with a substance use disorder). Overall, findings from the relatively small amount of available data indicate that pharmacotherapy for managing mood symptoms can be effective in patients with substance dependence, although results have not been consistent across all studies. Also, in most studies, medications for managing mood symptoms did not appear to have an impact on the substance use disorder. In a recent trial for comorbid major depression and alcohol dependence, combination treatment with a medication for depression and another for alcohol dependence was found to reduce depressive symptoms and excessive drinking simultaneously. However, research has only begun to address optimal pharmacologic management of co-occurring disorders. In addition, current clinical treatment for alcohol and drug dependence often excludes new pharmacotherapies approved by the U.S. Food and Drug Administration for treating certain types of addiction. With new data becoming available, it appears that we need to revisit current practice in the pharmacological management of co-occurring mood and substance use disorders.

  13. Asymmetric reproductive isolation during simultaneous reciprocal mating in pulmonates.

    Science.gov (United States)

    Wiwegweaw, Amporn; Seki, Keiichi; Mori, Hiroshi; Asami, Takahiro

    2009-04-23

    The generality of asymmetric reproductive isolation between reciprocal crosses suggests that the evolution of isolation mechanisms often proceeds in reciprocal asymmetry. In hermaphroditic snails that copulate simultaneously and reciprocally, asymmetry in premating isolation may not be readily detectable because the failure of the symmetric performance of courtship would prevent copulation from occurring. On the other hand, through their prolonged copulation, snails discriminate among mates when exchanging spermatophores for their benefit and thus may exhibit asymmetric reproductive isolation during interspecific mating. However, no clear case of reciprocal asymmetry has been found in reproductive isolation between snail species. Here we show a discrete difference in hybridization success between simultaneous reciprocal copulations between two species of pulmonate snails. Premating isolation of Bradybaena pellucida (BP) and Bradybaena similaris (BS) is incomplete in captivity. In interspecific copulation, BP removes its penis without transferring a spermatophore, while BS sires hybrids by inseminating BP. Thus, 'male' BP or 'female' BS rejects the other individual, while female BP and male BS accept each other, so that the two sexes of either BP or BS oppose each other in mate discrimination. Our results are a clear example of asymmetry in reproductive isolation during simultaneous reciprocal mating between hermaphroditic animals.

  14. Simultaneous invention and the patent law

    DEFF Research Database (Denmark)

    Howells, John; Katznelson, Ron D

    is typical of important pioneer inventions in both survey evidence and alleged illustrative cases of simultaneous invention. We show this in the cases of Edison, the Wright brothers, the Selden automobile patent vis a vis Ford, Watt and the steam engine. We then point out that patent law inherently ensures...... inventions they often find this to challenge the idea that patent law (which rewards only the first inventor with exclusive rights) is needed to encourage invention and innovation. We review the empirical evidence alleged to show that simultaneous invention is prevalent for important inventions. In general...... that patent protection is not extended to near simultaneous inventions. There remain a number of simultaneous inventions discovered through interference proceedings but we find the number too small to mount a serious challenge to the general operation of patent law....

  15. Antivesication by Simultaneous Prophylaxis and Detoxification

    National Research Council Canada - National Science Library

    Kwong, Cecil

    1996-01-01

    Our project DAMD17-93-C-3186 entitled 'Antivesication by Simultaneous Prophylaxis and Detoxification' has been directed toward the development of a new topically applied pretreatment that will prevent...

  16. Mechanisms underlying recovery of zooplankton in Lake Orta after liming

    Directory of Open Access Journals (Sweden)

    Roberta Piscia

    2016-04-01

    Full Text Available The goal of this study was to improve the understanding of the large-scale mechanisms underlying the recovery of the zooplankton of Lake Orta from historical contamination, following reduced input of ammonia and metals and the subsequent 1989/90 liming intervention. The industrial pollution had been severe and long-lasting (1929-1990. Zooplankton biodiversity has improved, but most of the new taxa appearing in our counts are rotifers, while many calanoids and the large cladoceran predators (Bythotrephes and Leptodora that are common in the nearby Lake Maggiore, were still absent from Lake Orta 17 years after liming. To aid understanding of the large-scale mechanisms controlling changes in annual richness, we assessed the annual persistence (P of Crustacea and Rotifera taxa as an estimator of whether propagules that survived introduction, as result of the natural recolonization process, also thrived. We found that the rate of introduction of zooplankton colonists and their persistence in the water column of Lake Orta changed from 1971 to 2007. New rotifer taxa appeared in the lake after the mid-1980s, when discharge of toxic substances decreased, but their annual persistence was low (P<0.5 until the turn of the century. The numerical values of rotifer and crustacean persistence in Lake Orta were unexpectedly high in 2001 and 2007 (0.55 and 0.72 for rotifers, 0.85 and 0.86 for crustacean, respectively, much higher than in limed lakes in Sudbury, Canada, and in adjacent Lake Maggiore. We hypothesize this could be related to the lack of Cladoceran predators and zooplanktivorous fish in the pelagic waters of Lake Orta.

  17. Tinnitus after Simultaneous and Sequential Bilateral Cochlear Implantation

    Directory of Open Access Journals (Sweden)

    Geerte G. J. Ramakers

    2017-11-01

    Full Text Available ImportanceThere is an ongoing global discussion on whether or not bilateral cochlear implantation should be standard care for bilateral deafness. Contrary to unilateral cochlear implantation, however, little is known about the effect of bilateral cochlear implantation on tinnitus.ObjectiveTo investigate tinnitus outcomes 1 year after bilateral cochlear implantation. Secondarily, to compare tinnitus outcomes between simultaneous and sequential bilateral cochlear implantation and to investigate long-term follow-up (3 years.Study designThis study is a secondary analysis as part of a multicenter randomized controlled trial.MethodsThirty-eight postlingually deafened adults were included in the original trial, in which the presence of tinnitus was not an inclusion criterion. All participants received cochlear implants (CIs because of profound hearing loss. Nineteen participants received bilateral CIs simultaneously and 19 participants received bilateral CIs sequentially with an inter-implant interval of 2 years. The prevalence and severity of tinnitus before and after simultaneous and sequential bilateral cochlear implantation were measured preoperatively and each year after implantation with the Tinnitus Handicap Inventory (THI and Tinnitus Questionnaire (TQ.ResultsThe prevalence of preoperative tinnitus was 42% (16/38. One year after bilateral implantation, there was a median difference of −8 (inter-quartile range (IQR: −28 to 4 in THI score and −9 (IQR: −17 to −9 in TQ score in the participants with preoperative tinnitus. Induction of tinnitus occurred in five participants, all in the simultaneous group, in the year after bilateral implantation. Although the preoperative and also the postoperative median THI and TQ scores were higher in the simultaneous group, the median difference scores were equal in both groups. In the simultaneous group, tinnitus scores fluctuated in the 3 years after implantation. In the sequential group

  18. Investigating the nature of co-occurring depression and anxiety: Comparing diagnostic and dimensional research approaches.

    Science.gov (United States)

    Kircanski, Katharina; LeMoult, Joelle; Ordaz, Sarah; Gotlib, Ian H

    2017-07-01

    Although approximately half of adults diagnosed with a depressive or anxiety disorder exhibit their simultaneous co-occurrence, traditional research has centered on single-target diagnoses, overlooking comorbidities within samples. In this article, we review and extend the literature that directly investigates co-occurring depression and anxiety, with the goal of shifting the focus from co-occurring diagnoses to symptom dimensions. First, we review studies that have directly compared psychobiological features (neural, neuroendocrine, autonomic) across depression, anxiety, and their co-occurrence, defined either categorically or dimensionally. Second, we analyze adults' diurnal cortisol secretion to examine the independent and interactive relations of continuously-assessed depressive and anxiety symptoms to neuroendocrine function. Previous findings on the psychobiology of diagnostic co-occurrence are mixed. While nascent, evidence from dimensionally focused studies suggests that co-occurring levels of depressive and anxiety symptoms can interact with one another, as reflected in a distinct psychobiological profile for individuals with high levels of both symptom dimensions. Results of our analyses support this formulation: we found that depressive and anxiety symptom dimensions interacted consistently in their relation to the measures of diurnal cortisol. The illustrative sample was relatively small and included only women; future research should examine generalizability of these findings. A dimensional approach to investigating the psychobiology of co-occurring depression and anxiety affords both conceptual and practical advantages. Simultaneously assessing depressive and anxiety symptom dimensions can efficiently capture their unique, shared, and interactive features, thereby identifying targets for intervention across a wide range of symptom presentations. Published by Elsevier B.V.

  19. Bayesian Calibration of Simultaneity in Audiovisual Temporal Order Judgments

    Science.gov (United States)

    Yamamoto, Shinya; Miyazaki, Makoto; Iwano, Takayuki; Kitazawa, Shigeru

    2012-01-01

    After repeated exposures to two successive audiovisual stimuli presented in one frequent order, participants eventually perceive a pair separated by some lag time in the same order as occurring simultaneously (lag adaptation). In contrast, we previously found that perceptual changes occurred in the opposite direction in response to tactile stimuli, conforming to Bayesian integration theory (Bayesian calibration). We further showed, in theory, that the effect of Bayesian calibration cannot be observed when the lag adaptation was fully operational. This led to the hypothesis that Bayesian calibration affects judgments regarding the order of audiovisual stimuli, but that this effect is concealed behind the lag adaptation mechanism. In the present study, we showed that lag adaptation is pitch-insensitive using two sounds at 1046 and 1480 Hz. This enabled us to cancel lag adaptation by associating one pitch with sound-first stimuli and the other with light-first stimuli. When we presented each type of stimulus (high- or low-tone) in a different block, the point of simultaneity shifted to “sound-first” for the pitch associated with sound-first stimuli, and to “light-first” for the pitch associated with light-first stimuli. These results are consistent with lag adaptation. In contrast, when we delivered each type of stimulus in a randomized order, the point of simultaneity shifted to “light-first” for the pitch associated with sound-first stimuli, and to “sound-first” for the pitch associated with light-first stimuli. The results clearly show that Bayesian calibration is pitch-specific and is at work behind pitch-insensitive lag adaptation during temporal order judgment of audiovisual stimuli. PMID:22792297

  20. Uranium occurences in calcrete and associated sediments in Western Australia

    International Nuclear Information System (INIS)

    Butt, C.R.M.; Horwitz, R.C.; Mann, A.W.

    1977-10-01

    The report is a compilation of data pertaining to the occurence and distribution of uranium mineralization in calcretes and associated sediments in Western Australia and contains brief descriptions of many of the calcrete-uranium occurences, including some of the most minor. Virtually all calcretes in the region are liable to contain traces of uranium mineralization, visible as coatings of carnotite. The locations of the uranium occurences are shown on a map which features the distribution of calcrete

  1. Co-Occuring Directions Sketching for Approximate Matrix Multiply

    OpenAIRE

    Mroueh, Youssef; Marcheret, Etienne; Goel, Vaibhava

    2016-01-01

    We introduce co-occurring directions sketching, a deterministic algorithm for approximate matrix product (AMM), in the streaming model. We show that co-occuring directions achieves a better error bound for AMM than other randomized and deterministic approaches for AMM. Co-occurring directions gives a $1 + \\epsilon$ -approximation of the optimal low rank approximation of a matrix product. Empirically our algorithm outperforms competing methods for AMM, for a small sketch size. We validate empi...

  2. Alterations in audiovisual simultaneity perception in amblyopia.

    Science.gov (United States)

    Richards, Michael D; Goltz, Herbert C; Wong, Agnes M F

    2017-01-01

    Amblyopia is a developmental visual impairment that is increasingly recognized to affect higher-level perceptual and multisensory processes. To further investigate the audiovisual (AV) perceptual impairments associated with this condition, we characterized the temporal interval in which asynchronous auditory and visual stimuli are perceived as simultaneous 50% of the time (i.e., the AV simultaneity window). Adults with unilateral amblyopia (n = 17) and visually normal controls (n = 17) judged the simultaneity of a flash and a click presented with both eyes viewing. The signal onset asynchrony (SOA) varied from 0 ms to 450 ms for auditory-lead and visual-lead conditions. A subset of participants with amblyopia (n = 6) was tested monocularly. Compared to the control group, the auditory-lead side of the AV simultaneity window was widened by 48 ms (36%; p = 0.002), whereas that of the visual-lead side was widened by 86 ms (37%; p = 0.02). The overall mean window width was 500 ms, compared to 366 ms among controls (37% wider; p = 0.002). Among participants with amblyopia, the simultaneity window parameters were unchanged by viewing condition, but subgroup analysis revealed differential effects on the parameters by amblyopia severity, etiology, and foveal suppression status. Possible mechanisms to explain these findings include visual temporal uncertainty, interocular perceptual latency asymmetry, and disruption of normal developmental tuning of sensitivity to audiovisual asynchrony.

  3. Biochemical changes occurring during fermentation of camel milk by ...

    African Journals Online (AJOL)

    Biochemical changes occurring during fermentation of camel milk by selected bacterial starter cultures. ... Abstract. The biochemical changes in amino acids, water soluble vitamins, soluble sugars and organic acids occurring during fermentation (at 43°C for 6 h) of camel milk inoculated with Streptococcus thermophilus 37, ...

  4. Wild chimpanzees can perform social grooming and social play behaviors simultaneously.

    Science.gov (United States)

    Shimada, Masaki

    2013-10-01

    Reliable evidence was obtained of the simultaneous performance of social grooming and social play behaviors by individuals among wild chimpanzees of the M group in Mahale Mountains National Park. I observed three cases of this performance: in an old female, a young female, and an adult male. While the agent was grooming the back of an adult bimanually, an infant or a juvenile approached the agent. The agent then started playing with the infant/juvenile using only the right hand, while simultaneously grooming the back of the adult with the left hand. In one case, an old female continued the simultaneous performance for about 1 min. Such performances probably occur at low frequency because they are not often required. The similarity in the neurobiological bases and the functions of social grooming and social play behaviors, both of which include repetitive contact with the body of another individual, may facilitate their simultaneous performance.

  5. Multichannel simultaneous magnetic induction measurement system (MUSIMITOS)

    International Nuclear Information System (INIS)

    Steffen, Matthias; Leonhardt, Steffen; Heimann, Konrad; Bernstein, Nina

    2008-01-01

    Non-contact heart and lung activity monitoring would be a desirable supplement to conventional monitoring techniques. Based on the potential of non-contact magnetic induction measurements, requirements for an adequate monitoring system were estimated. This formed the basis for the development of the presented extendable multichannel simultaneous magnetic induction measurement system (MUSIMITOS). Special focus was given to the dynamic behaviour and simultaneous multichannel measurements, so that the system allows for up to 14 receiver coils working simultaneously at 6 excitation frequencies. Moreover, a real-time software concept for online signal processing visualization in combination with a fast software demodulation is presented. Finally, first steps towards a clinical application are pointed out and technical performance as well as first in vivo measurements are presented. This paper covers some aspects previously presented in Steffen and Leonhardt (2007 Proc. 13th Int. Conf. on Electrical Bioimpedance and the 8th Conf. on Electrical Impedance Tomography, Graz 2007)

  6. The Role of Co-occurring Emotions and Personality Traits in Anger Expression

    Science.gov (United States)

    Mill, Aire; Kööts-Ausmees, Liisi; Allik, Jüri; Realo, Anu

    2018-01-01

    The main aim of the current study was to examine the role of co-occurring emotions and their interactive effects with the Big Five personality traits in anger expression. Everyday anger expression (“anger-in” and “anger-out” behavior) was studied with the experience-sampling method in a group of 110 participants for 14 consecutive days on 7 random occasions per day. Our results showed that the simultaneously co-occurring emotions that buffer against anger expression are sadness, surprise, disgust, disappointment, and irritation for anger-in behavior, and fear, sadness and disappointment for anger-out reactions. While previous studies have shown that differentiating one's current affect into discrete emotion categories buffers against anger expression (Pond et al., 2012), our study further demonstrated the existence of specific interactive effects between the experience of momentary emotions and personality traits that lead to higher levels of either suppression or expression of anger behavior (or both). For example, the interaction between the trait Openness and co-occurring surprise, in predicting anger-in behavior, indicates that less open people hold their anger back more, and more open people use less anger-in behavior. Co-occurring disgust increases anger-out reactions in people low in Conscientiousness, but decreases anger-out reactions in people high in Conscientiousness. People high in Neuroticism are less likely to engage in anger-in behavior when experiencing disgust, surprise, or irritation alongside anger, but show more anger out in the case of co-occurring contempt. The results of the current study help to further clarify the interactions between the basic personality traits and the experience of momentary co-occurring emotions in determining anger behavior. PMID:29479333

  7. Implicit misattribution of evaluative responses: contingency-unaware evaluative conditioning requires simultaneous stimulus presentations.

    Science.gov (United States)

    Hütter, Mandy; Sweldens, Steven

    2013-08-01

    Recent research has shown that evaluative conditioning (EC) procedures can change attitudes without participants' awareness of the contingencies between conditioned and unconditioned stimuli (Hütter, Sweldens, Stahl, Unkelbach, & Klauer, 2012). We present a theoretical explanation and boundary condition for the emergence of unaware EC effects based on the implicit misattribution of evaluative responses from unconditioned to conditioned stimuli. We hypothesize that such misattribution is only possible when conditioned and unconditioned stimuli are perceived simultaneously. Therefore we manipulate the simultaneity of the stimulus presentations and apply a process dissociation procedure to distinguish contingency-aware from contingency-unaware EC effects. A multinomial model indicates that with sequential presentations, EC effects do not occur without contingency awareness. However, unaware EC effects do occur with simultaneous presentations. The findings support dual-process theories of learning. PsycINFO Database Record (c) 2013 APA, all rights reserved.

  8. Simultaneous wireless electrophysiological and neurochemical monitoring

    Science.gov (United States)

    Murari, Kartikeya; Mollazadeh, Mohsen; Thakor, Nitish; Cauwenberghs, Gert

    2008-08-01

    Information processing and propagation in the central nervous system is mostly electrical in nature. At synapses, electrical signals cause the release of neurotransmitters like dopamine, glutamate etc., that are sensed by post-synaptic neurons resulting in signal propagation or inhibition. It can be very informative to monitor electrical and neurochemical signals simultaneously to understand the mechanisms underlying normal or abnormal brain function. We present an integrated system for the simultaneous wireless acquisition of neurophysiological and neurochemical activity. Applications of the system to neuroscience include monitoring EEG and glutamate in rat somatosensory cortex following global ischemia.

  9. A simultaneous facility location and vehicle routing problem arising in health care logistics in the Netherlands

    NARCIS (Netherlands)

    Veenstra, Marjolein; Roodbergen, Kees Jan; Coelho, Leandro C.; Zhu, Stuart X.

    2018-01-01

    This paper introduces a simultaneous facility location and vehicle routing problem that arises in health care logistics in the Netherlands. In this problem, the delivery of medication from a local pharmacy can occur via lockers, from where patients that are within the coverage distance of a locker

  10. Two simultaneous autoimmune processes in a patient presenting with respiratory insufficiency

    OpenAIRE

    Troy, Lauren; Hamor, Paul; Bleasel, Jane; Corte, Tamera

    2013-01-01

    The idiopathic inflammatory myopathies, including dermatomyositis, are uncommon acquired autoimmune diseases, sometimes associated with interstitial lung disease. Myasthenia gravis, a separate autoimmune disorder involving the neuromuscular junction, has some overlapping clinical features but has only rarely been reported to occur simultaneously within the same patient. Here we present the first reported case of concomitant dermatomyositis, myasthenia gravis, and interstitial lung disease.

  11. Simultaneous declines in summer survival of three shorebird species signals a flyway at risk

    NARCIS (Netherlands)

    Piersma, Theunis; Lok, Tamar; Chen, Ying; Hassell, Chris J.; Yang, Hong-yan; Boyle, Adrian; Slaymaker, Matt; Chan, Ying-chi; Melville, David S.; Zhang, Zheng-wang; Ma, Zhijun

    2016-01-01

    1. There is increasing concern about the world’s animal migrations. With many land-use and climatological changes occurring simultaneously, pinning down the causes of large-scale conservation problems requires sophisticated and data-intensive approaches. 2. Declining shorebird numbers along the East

  12. Simultaneous declines in summer survival of three shorebird species signals a flyway at risk

    NARCIS (Netherlands)

    Piersma, T.; Lok, T.; Chen, Y.; Hassell, C.J.; Yang, H.-Y.; Boyle, A.; Slaymaker, M.; Chan, Y.-C; Melville, D.S.; Zhang, Z.W.; Ma, Z.

    2016-01-01

    There is increasing concern about the world’s animal migrations. With many land-use andclimatological changes occurring simultaneously, pinning down the causes of large-scale conservationproblems requires sophisticated and data-intensive approaches.2. Declining shorebird numbers along the East

  13. Bilateral simultaneous quadriceps tendon rupture in a patient with secondary hyperparathyroidism: a case report

    International Nuclear Information System (INIS)

    Lee, Yeon Soo; Son, Sang Beom; Han, Chang Whan; Kang, Si Won

    2001-01-01

    Simultaneous bilateral rupture of the quadriceps tendon without a significant history of trauma may occur in association with chronic metabolic disorders such as chronic renal failure and secondary hyperparathyroidism, though has rarely been reported. We describe a case of spontaneous bilateral quadriceps tendon rupture in a 36-year-old female patient with secondary hyperparathyroidism

  14. Synthetic and naturally occurring hydrazines as possible cancer causative agents.

    Science.gov (United States)

    Toth, B

    1975-12-01

    The various synthetic substituted hydrazines, which cause tumors in animals, are briefly enumerated. To date, 19 of them have proved to be tumorigenic in animals. A number of these chemicals are found today in the environment, in industry, in agriculture, and in medicine, and the human population is exposed to a certain degree to some of them. Hydrazine also occurs in nature in tobacco and tobacco smoke. The three other naturally occurring hydrazine compounds are N-methyl-N-formylhydrazine, which occurs in the wild edible mushroom, Gyromitra esculenta, and beta-N-[gamma-L(+)-glutamyl]-4-hydroxymethylphenylhydrazine and 4-hydroxymethylphenylhydrazine, which are found in the commonly eaten cultivated mushroom, Agaricus bisporus. Tumorigenesis studies with the naturally occurring hydrazines are in progress.

  15. Self-Stigma, Identity, and Co-Occurring Disorders.

    Science.gov (United States)

    Al-Khouja, Maya A; Corrigan, Patrick W

    2017-01-01

    A four stage regressive model that links public stigma to self-stigma is applied to mental illness and substance use disorder. We assess this four stage model in those with co-occurring disorders versus those who have mental illness or substance use disorder alone. 366 people who self-identified as having either a mental illness or co-occurring mental illness with substance use disorder were recruited from MTurk and completed measures on identity and self-stigma. Higher group identity predicted lower selfstigma in those with mental illness while this effect was not present for participants with co-occurring disorders. Limitations include that this study only looked at mental illness identity for those with both mental illness and substance use disorder; sample limitations are also discussed. Those with co-occurring disorders may identify more with certain groups over others.

  16. Auto-immune haematological complications occurring during the ...

    African Journals Online (AJOL)

    Auto-immune haematological complications occurring during treatment for malignant Iymphoproliferative diseases are described in 5 patients. There appeared to be a temporal relationship between the development of these complications and the administration of chemotherapeutic drugs or extensive radiotherapy.

  17. Comparative Toxicology of Libby Amphibole and Naturally Occurring Asbestos

    Science.gov (United States)

    Summary sentence: Comparative toxicology of Libby amphibole (LA) and site-specific naturally occurring asbestos (NOA) provides new insights on physical properties influencing health effects and mechanisms of asbestos-induced inflammation, fibrosis, and tumorigenesis.Introduction/...

  18. Simultaneous determination of naproxen, ibuprofen and diclofenac ...

    African Journals Online (AJOL)

    Simultaneous determination of naproxen, ibuprofen and diclofenac in wastewater using solid-phase extraction with high performance liquid chromatography. ... The instrument quantification limits obtained were 0.1 μg·L-1, for naproxen and 0.4 μg·L-1 for both ibuprofen and diclofenac. The detected concentrations for ...

  19. Optimization of bioethanol production from simultaneous ...

    African Journals Online (AJOL)

    In this study, bioethanol production from the simultaneous saccharification and fermentation (SSF) of pineapple peels using cellulase and Saccharomyces cerevisiae was investigated. A three-factor Box-behnken design (BBD) and response surface methodology (RSM) were employed to study the effect of broth pH (2-6), ...

  20. Scaling in ANOVA-simultaneous component analysis

    NARCIS (Netherlands)

    Timmerman, M.E; Hoefsloot, H.C.J.; Smilde, A.K.; Ceulemans, E.

    2015-01-01

    In omics research often high-dimensional data is collected according to an experimental design. Typically, the manipulations involved yield differential effects on subsets of variables. An effective approach to identify those effects is ANOVA-simultaneous component analysis (ASCA), which combines

  1. influence of simultaneous infestations of prostephanus truncatus ...

    African Journals Online (AJOL)

    significant differences in the percentage change of adult insect numbers between single and simultaneous infestations at P< 0.01. Further, the grain ... complete development over a wide range of temperatures, 270C to 320C and between ... Aging, sexing and conditioning P. truncatus and S. zeamais. Adults were removed ...

  2. Simultaneous estimation of earthquake source parameters and ...

    Indian Academy of Sciences (India)

    stress drop values are quite large compared to the other similar size Indian intraplate earthquakes, which can be attributed ... Earthquake source parameters; crustal Q-value; simultaneous inversion; S-wave spectra; aftershocks. J. Earth Syst. Sci. ...... 28 1339–1342. Lee W H K and Valdes C M 1985 HYP071PC: A personal.

  3. Simultaneous Visual Discrimination in Asian Elephants

    Science.gov (United States)

    Nissani, Moti; Hoefler-Nissani, Donna; Lay, U. Tin; Htun, U. Wan

    2005-01-01

    Two experiments explored the behavior of 20 Asian elephants ("Elephas aximus") in simultaneous visual discrimination tasks. In Experiment 1, 7 Burmese logging elephants acquired a white+/black- discrimination, reaching criterion in a mean of 2.6 sessions and 117 discrete trials, whereas 4 elephants acquired a black+/white- discrimination in 5.3…

  4. Simultaneous Multi-Element Electrothermal Atomic Absorption ...

    African Journals Online (AJOL)

    NICO

    Simultaneous Multi-Element Electrothermal Atomic. Absorption Determination Using a Low Resolution CCD. Spectrometer and Continuum Light Source: The Concept and Methodology. Dimitri A. Katskov* and G. Eunice Khanye. Department of Chemistry and Physics, Tshwane University of Technology, Pretoria, 0001 South ...

  5. Reproductive strategies of a simultaneous hermaphrodite

    NARCIS (Netherlands)

    Nakadera, Y.

    2014-01-01

    Reproductive strategies in a simultaneous hermaphrodite All the extant organisms are the consequence of reproduction by ancestors. This fact naturally invokes the urge to know how organisms managed to reproduce. Therefore, I studied reproductive strategy, which is defined as a set of (behavioural,

  6. Simultaneous Quantification of Paracetamol and Meloxicam in ...

    African Journals Online (AJOL)

    Purpose: To develop and validate a simple, rapid and inexpensive RP-HPLC method for the simultaneous estimation of paracetamol and meloxicam in tablets. Methods: For the analysis of the drugs, chromatographic analysis was performed on XTerra symmetry C18 column (100 × 4.6 mm, 5 μ particle size) with mobile ...

  7. Simultaneous Estimation of Sitagliptin and Metformin in ...

    African Journals Online (AJOL)

    A rapid, simple, specific and precise high-performance thin-layer chromatography (HPTLC) method was developed for the simultaneous estimation of sitagliptin (STG) and metformin (MET) content in a fixed dose pharmaceutical formulation and also in bulk drug. In the developed method, aluminium backed silica gel 60 ...

  8. Simultaneous Spectrophotometric Determination of Valsartan and ...

    African Journals Online (AJOL)

    Purpose: To develop a direct, simple and extraction-free spectrophotometric method for the simultaneous estimation of valsartan and ezetimibe in pharmaceuticals. Methods: A spectrophotometric method for the determination of valsartan and ezetimibe was developed using acidic dyes, namely, bromophenol blue (BPB) ...

  9. Simultaneous approximation in scales of Banach spaces

    International Nuclear Information System (INIS)

    Bramble, J.H.; Scott, R.

    1978-01-01

    The problem of verifying optimal approximation simultaneously in different norms in a Banach scale is reduced to verification of optimal approximation in the highest order norm. The basic tool used is the Banach space interpolation method developed by Lions and Peetre. Applications are given to several problems arising in the theory of finite element methods

  10. Simultaneous determination of isoniazid and pyrazinamide in ...

    African Journals Online (AJOL)

    Purpose: To develop and validate a new high performance liquid chromatographic (HPLC) method for the simultaneous determination of isoniazid (INH) and pyrazinamide (PZA) in plasma. Methods: A 150 μL aliquot of plasma was mixed with 75 μL of 10 % trichloroacetic acid containing 100 mg/L of acetanilide as the ...

  11. Simultaneous Determination of Mutagenicity and Toxicity of ...

    African Journals Online (AJOL)

    A demonstration of cytotoxicity is required (measurement of cell number, culture confluency and inhibition of mitotic index) for in vitro cytogenetic assays. The study therefore investigated whether delayed cytotoxicity can be used to simultaneously predict mutagenicity and cytotoxicty. Chinese hamster lung cells were ...

  12. Simultaneous Quantification of Paracetamol and Meloxicam in ...

    African Journals Online (AJOL)

    Erah

    Purpose: To develop and validate a simple, rapid and inexpensive RP-HPLC method for the simultaneous estimation of paracetamol and meloxicam in tablets. Methods: For the analysis of the drugs, chromatographic analysis was performed on XTerra symmetry. C18 column (100 × 4.6 mm, 5 µ particle size) with mobile ...

  13. Simultaneous Determination of Seven Constituents in Herbal ...

    African Journals Online (AJOL)

    Simultaneous Determination of Seven Constituents in Herbal Prescription Jaeumganghwa-Tang Using HPLC-PDA. CS Seo, JH Kim, HK Shin. Abstract. A simple and accurate high-performance liquid chromatographic method was applied to the quantitative analysis of seven components of the traditional herbal prescription ...

  14. influence of simultaneous infestations of prostephanus truncatus ...

    African Journals Online (AJOL)

    infestations on their reproductive performance and on the damage they cause to maize variety ZM. 621 with 12.5% moisture content. The specific objective was to determine the number of the insect pests at F1 and F2 and the grain weight losses caused by the simultaneous pests' ... IPM is a system that, in the context of the.

  15. Simultaneous estimation of earthquake source parameters and ...

    Indian Academy of Sciences (India)

    This paper presents the simultaneous estimation of source parameters and crustal Q values for small to moderate-size aftershocks ( 2.1–5.1) of the 7.7 2001 Bhuj earthquake. The horizontal-component S-waves of 144 well located earthquakes (2001–2010) recorded at 3–10 broadband seismograph sites in the ...

  16. Simultaneous Determination of Ciprofloxacin and Tinidazole in ...

    African Journals Online (AJOL)

    Purpose: To develop a simple, sensitive and specific liquid chromatographic method with PDA detection for the simultaneous estimation of ciprofloxacin and tinidazole in tablet dosage form. Methods: Separation was achieved with an Agilent XDB C18, 250 × 4.60 mm 5 μ column, low pressure gradient mode with a ambient ...

  17. Influence of simultaneous infestations of Prostephanus truncatus ...

    African Journals Online (AJOL)

    The specific objective was to determine the number of the insect pests at F1 and F2 and the grain weight losses caused by the simultaneous pests\\' infestations of shelled maize in the search for a control strategy. The results showed a change in adult insect numbers from F1 to F2. During single infestation the change in P.

  18. Simultaneous adsorption and biodegradation of synthetic melanoidin

    African Journals Online (AJOL)

    Being an antioxidant, melanoidin removal through purely biodegradation has been inadequate. Consequently, in the current study, simultaneous adsorption and biodegradation (SAB) was employed in a stirred tank system to remove melanoidin from synthetic wastewater. Mixed microbial consortium was immobilized onto ...

  19. Simultaneous estimation of earthquake source parameters and ...

    Indian Academy of Sciences (India)

    This paper presents the simultaneous estimation of source parameters and crustal Q values for small to moderate-size aftershocks (Mw 2.1–5.1) of the Mw 7.7 2001 Bhuj earthquake. The horizontal-component. S-waves of 144 well located earthquakes (2001–2010) recorded at 3–10 broadband seismograph sites in.

  20. Simultaneous Multi-Element Electrothermal Atomic Absorption ...

    African Journals Online (AJOL)

    width of transmittance profile 120 pm, a linear CCD array attached to a PC and a tube atomizer furnished with a carbon fibre collector. In the experiments simultaneous determination of 18 elements was performed in the mixed solutions at the mg ...

  1. Simultaneous Transesterification of Baobab Seed (Adansonia ...

    African Journals Online (AJOL)

    The properties of the Baobab seed methyl ester gave the following: specific gravity, 0.87, pour point, -6 oC, cloud point, 2 oC, flash point, 150 oC, Cetane number , 49, which is comparable with the ASTM D6751 standards for methyl esters. Keywords: Heterogeneous catalyst, Simultaneous transesterification, Baobab seed, ...

  2. Treatment of co-occurring psychotic and substance use disorders.

    Science.gov (United States)

    Mueser, Kim T; Gingerich, Susan

    2013-01-01

    People with psychotic disorders and other serious mental illnesses, such as schizophrenia, bipolar disorder, and severe major depression, have high rates of co-occurring substance use disorder, which can wreak havoc in their lives. In this article the authors describe strategies for assessing substance use problems in people with serious mental illnesses, and then address the treatment of these co-occurring disorders. The authors review principles of treatment of co-occurring disorders, including integration of mental health and substance abuse services, adopting a low-stress and harm-reduction approach, enhancing motivation, using cognitive-behavioral therapy strategies to teach more effective interpersonal and coping skills, supporting functional recovery, and engaging the social network. The authors include a section on how social workers may play a key role in assessment, treatment, or referral for co-occurring disorders in a variety of settings. Throughout the article the authors emphasize that belief in the possibility of recovery from co-occurring disorders and instilling hope in clients, their family members, and other treatment providers, are vital to the effective treatment of co-occurring disorders.

  3. Radiation therapy and simultaneous chemotherapy for recurrent cervical carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Windschall, A.; Ott, O.J.; Sauer, R.; Strnad, V. [Erlangen Univ. (Germany). Dept. of Radiation Oncology

    2005-08-01

    Purpose: To evaluate the efficacy and toxicity in patients with recurrence of cervical cancer treated with radiotherapy and simultaneous chemotherapy. Patients and methods: Between 1987 and 2001, 24 patients with recurrent cervical carcinoma were treated with concurrent chemoradiotherapy. Nine patients had incomplete tumor resection prior to radiation therapy. Irradiation was delivered to a total dose of 60 Gy, in three patients with central recurrence supplemented by brachytherapy. One patient was treated with brachytherapy alone. Simultaneous chemotherapy was done as a combined therapy of 5-fluorouracil-(5-FU, 600 mg/m{sup 2}/d1-5, 29-33) and cisplatin (20 mg/m{sup 2}/d1-5, 29-33; 16/24 patients) or of 5-FU (1,000 mg/m{sup 2}/d1-5, 29-33) and mitomycin C (10 mg/m{sup 2}/d2, 30; 1/24 patients). Cisplatin alone (25 mg/m{sup 2}/d1-5) and carboplatin alone (800 mg/m{sup 2}/d1-5) were administered in 5/24 patients (21%) and 2/24 patients (8%). Results: The 5-year local recurrence-free survival rate was 37%, disease-free survival 33%, and overall survival 34%. Grade 3 toxicity (NCI-CTC grade 3) occurred mainly as diarrhea (38%), leukopenia (33%), and nausea (21%). Severe toxicity (grade 4) was not seen in any of the patients. Conclusion: Radiation therapy with simultaneous chemotherapy for recurrences of cervical cancer is an effective treatment with acceptable toxicity. (orig.)

  4. Nuclear fusion during yeast mating occurs by a three-step pathway.

    Science.gov (United States)

    Melloy, Patricia; Shen, Shu; White, Erin; McIntosh, J Richard; Rose, Mark D

    2007-11-19

    In Saccharomyces cerevisiae, mating culminates in nuclear fusion to produce a diploid zygote. Two models for nuclear fusion have been proposed: a one-step model in which the outer and inner nuclear membranes and the spindle pole bodies (SPBs) fuse simultaneously and a three-step model in which the three events occur separately. To differentiate between these models, we used electron tomography and time-lapse light microscopy of early stage wild-type zygotes. We observe two distinct SPBs in approximately 80% of zygotes that contain fused nuclei, whereas we only see fused or partially fused SPBs in zygotes in which the site of nuclear envelope (NE) fusion is already dilated. This demonstrates that SPB fusion occurs after NE fusion. Time-lapse microscopy of zygotes containing fluorescent protein tags that localize to either the NE lumen or the nucleoplasm demonstrates that outer membrane fusion precedes inner membrane fusion. We conclude that nuclear fusion occurs by a three-step pathway.

  5. [Co-occuring mood and substance use disorders].

    Science.gov (United States)

    Adida, M; Kaladjian, A; Fakra, E; Belzeaux, R; Azorin, J M

    2014-12-01

    Mood and substance use disorders commonly co-occur, yet there is little evidence-based research to guide the pharmacologic management of these comorbid disorders. The authors review the existing empirical findings including current clinical pharmacotherapy practices for treating co-occurring mood and substance use disorders and call into question current clinical practices. The specific mood disorders reviewed are bipolar and major depressive disorders (either one co-occurring with a substance use disorder). The authors also highlight knowledge gaps that may serve as a basis for future research. Findings from the relatively small amount of available data indicate that pharmacotherapy for managing mood symptoms might be effective in patients with substance dependence, although results have not been consistent across all studies. In most studies, medications for managing mood symptoms did not appear to have an impact on the substance use disorder. Research has only begun to address optimal pharmacologic management of co-occurring disorders. In addition, current clinical treatment for drug dependence often exclude new pharmacotherapies approved by the French Haute Autorité de Santé for treating certain types of addiction. With new data becoming available, it appears that we need to revisit current practice in the pharmacological management of co-occurring mood and substance use disorders. Copyright © 2014 L’Encéphale. Published by Elsevier Masson SAS.. All rights reserved.

  6. Transcendental and interpolation methods in simultaneous stabilization and simultaneous partial pole placement problems

    Science.gov (United States)

    Ghosh, B. K.

    1986-01-01

    The existence of a compensator which simultaneously renders a given r-tuple of multiinput-multioutput p x m linear dynamical systems internally stable is investigated. In particular, a set of simultaneously stabilizable r-tuples of plants is parametrized, and it is shown that, provided r = max(m,p) or less, the above set is semialgebraic and dense in the space Sigma of r-tuples of plants. An extension of the classical pole placement and stabilization problems is considered, and the simultaneous partial pole placement problem is investigated.

  7. Endometrial carcinoma occuring from polycystic ovary disease : A case report

    Energy Technology Data Exchange (ETDEWEB)

    Seong, Su Ok; Jeon, Woo Ki [Inje Univ. College of Medicine, Seoul (Korea, Republic of)

    1996-12-01

    Endometrial carcinoma usually occurs in postmenopausal women ; less than 5% occurs in women under the age of 40. Up to one quarter of endometrial carcinoma patients below this age have PCO(polycystic ovary disease, Stein-Leventhal syndrome). The increased incidence of endometrial carcinoma in patients with PCO is related to chronic estrogenic stimulation. We report MR imaging in one case of endometrial carcinoma occuring in a 23 year old woman with PCO and had complained of hypermenorrhea for about three years. On T2-weighted MR image the endometrial cavity was seen to be distended with protruded endometrial masses of intermediate signal intensity, and the junctional zone was disrupted beneath the masses. Both ovaries were best seen on T2-weighted MR imaging and showed multiple small peripheral cysts and low signal-intensity central stroma.

  8. Endometrial carcinoma occuring from polycystic ovary disease : A case report

    International Nuclear Information System (INIS)

    Seong, Su Ok; Jeon, Woo Ki

    1996-01-01

    Endometrial carcinoma usually occurs in postmenopausal women ; less than 5% occurs in women under the age of 40. Up to one quarter of endometrial carcinoma patients below this age have PCO(polycystic ovary disease, Stein-Leventhal syndrome). The increased incidence of endometrial carcinoma in patients with PCO is related to chronic estrogenic stimulation. We report MR imaging in one case of endometrial carcinoma occuring in a 23 year old woman with PCO and had complained of hypermenorrhea for about three years. On T2-weighted MR image the endometrial cavity was seen to be distended with protruded endometrial masses of intermediate signal intensity, and the junctional zone was disrupted beneath the masses. Both ovaries were best seen on T2-weighted MR imaging and showed multiple small peripheral cysts and low signal-intensity central stroma

  9. Distributed synchronization of coupled neural networks via randomly occurring control.

    Science.gov (United States)

    Tang, Yang; Wong, Wai Keung

    2013-03-01

    In this paper, we study the distributed synchronization and pinning distributed synchronization of stochastic coupled neural networks via randomly occurring control. Two Bernoulli stochastic variables are used to describe the occurrences of distributed adaptive control and updating law according to certain probabilities. Both distributed adaptive control and updating law for each vertex in a network depend on state information on each vertex's neighborhood. By constructing appropriate Lyapunov functions and employing stochastic analysis techniques, we prove that the distributed synchronization and the distributed pinning synchronization of stochastic complex networks can be achieved in mean square. Additionally, randomly occurring distributed control is compared with periodically intermittent control. It is revealed that, although randomly occurring control is an intermediate method among the three types of control in terms of control costs and convergence rates, it has fewer restrictions to implement and can be more easily applied in practice than periodically intermittent control.

  10. Relations between the simultaneous and sequential transfer of two nucleons

    International Nuclear Information System (INIS)

    Satchler, G.R.

    1982-01-01

    The transfer of two nucleons between projectile and target in a direct or peripheral reaction such as (p,t) or ( 16 O, 14 C) may occur in one-step or two-steps. These we refer to as simultaneous and sequential transfers, respectively. In the former, the interaction acts once and both nucleons are transferred. In the latter, the interaction acts once to transfer one nucleon, the system then propagates in one or more intermediate states and is followed by a second action of the interaction to transfer the second nucleon. This process may be symbolized for the above examples as (p,d;d,t) and ( 16 O, 15 N; 15 N, 14 C), implying the intermediate formation of a deuteron or the nucleus 15 N. (Of course, the intermediate system may exist in more than one state of excitation). For simplicity, the (t,p) reaction is chosen to illustrate the theory

  11. Simultaneous caving and surface restoration system for oil shale mining

    Energy Technology Data Exchange (ETDEWEB)

    Allsman, P.T.

    1968-10-01

    A modified caving method is introduced for mining oil shale and simultaneous restoration of the land surface by return of spent shale onto the subsided area. Other methods have been designed to mine the relatively thin richer beds occurring near outcrops in the Piceance Creek Basin of NW. Colorado. Since the discovery of the much thicker beds in the N.-central part of the basin, some attention has focused on in situ and open-pit methods of recovery. Although caving has been recognized as a possible means of mining shale, most people have been skeptical of its success. This stems from the unknown and salient factors of cavability and size of broken rock with caving. Wisdom would seem to dictate that serious evaluation of the caving method be made along with the other methods.

  12. Factors affecting the depth of burns occurring in medical institutions.

    Science.gov (United States)

    Cho, Young Soon; Choi, Young Hwan; Yoon, Cheonjae; You, Je Sung

    2015-05-01

    Most cases of burns occurring in medical institutions are associated with activities involving heat. It is very difficult to detect these burns. To date, there are few reports on burns occurring in medical institutions. The purpose of this paper was to analyze the etiology of burns occurring in medical institutions and to elucidate the factors affecting burn depth. We conducted a retrospective analysis of the medical records of patients who visited our center from April 2008 to February 2013. This study enrolled all patients with burns occurring in the medical institution during or related to treatment. We excluded burn patients whose burns were not related to treatment (for example, we excluded patients with scalding burns that occurred in the hospital cafeteria and pediatric patients with hot water burns from the water purifier). However, patients with burns that occurred in the recovery room after general anesthesia were included. A total of 115 patients were enrolled in this study. The average patient age was 41.5 years, with more women than men (M:F=31:84). There were 29 cases (25.3%) of superficial burns (first-degree and superficial second-degree) and 86 cases (74.7%) of deep burns (deep second-degree and third-degree). Hot packs were the most common cause of burns (27 cases, 23.5%), followed by laser therapy, heating pads, and grounding pads, accounting for 15 cases each. There were 89 cases (77.4%) of contact burns and 26 cases (22.6%) of non-contact burns. The most common site of burns was the lower extremities (41 cases, 35.7%). The burn site and contact burns were both factors affecting burn depth. The rate of deep burns was higher in patients with contact burns than in those with non-contact burns (odds ratio 4.26) and was associated with lower body burns (odds ratio 2.85). In burns occurring in medical institutions, there is a high probability of a deep burn if it is a contact burn or occurs in the lower body. Therefore, safety guidelines are needed

  13. Total retinal detachment occurring after minor head trauma.

    Science.gov (United States)

    Mircea, Pienaru; Ramona, Serban; Mircea, Filip; Andrei, Filip

    2015-01-01

    The objective of this article is to present the case of a patient with a severe decrease of visual acuity that occurred after an apparently minor head injury. Following the investigations, the patient was diagnosed with rhegmatogenous retinal detachment that was triggered by a fall from the same level and which occurred on a background of lattice degeneration. In this case, a minor trauma caused a severe complication because the patient had a contributing factor for the complication. The patient was operated and the end result was satisfactory.

  14. Geotechnical problems that occur due to the fact of groundwater

    Directory of Open Access Journals (Sweden)

    Grujić Bojana

    2016-01-01

    Full Text Available Beginning from the basic views on the main problem that occurs due to hydro-geomechanical processes, in particular the driving force caused by changing the pressure of groundwater, this paper will provide a review of the assessment of stresses and strains in the soil (soil and rock. The solution is a combination of the system of equations of the soil and ground water flow and caused geotechnical stresses or problems that occur in the soil. The paper will describe in detail the problem of subsidence due to pumping of water in the open pit-field problems and assessment of seepage forces in saturated or unsaturated loose materials.

  15. Why Does Bureaucratic Corruption Occur in the EU?

    DEFF Research Database (Denmark)

    Brandt, Urs Steiner; Svendsen, Gert Tinggaard

    2013-01-01

    Why does bureaucratic corruption occur in the EU system? Several examples suggest that bureaucratic corruption exists and that the Commission’s anti-fraud agency, OLAF, is not a fully independent authority. We thus develop a novel interpretation of the principalsupervisor-agent model to cope...... with non-independent anti-fraud units. This model shows that corruption is likely to occur when the expected value to the client from bribing the agent is larger than the expected value to the principal of truth-telling by the supervisor. Overall, this analysis points to the risks of flawed incentives...

  16. The dilemma of simultaneous or successive bilingualism

    Directory of Open Access Journals (Sweden)

    Marina Furlan

    2002-12-01

    Full Text Available The study starts from the definition of bilingualism, according to which a person is considered to be bilingual, if she had started to learn (in natural situations two languages from her birth or from early childhood on. The aim of this research work was to assess the existence of any personality differences among "simultaneous" (children exposed to both languages from birth on or at least before the first birthday and "successive" (children exposed to the first language from birth on and to the second language from the toddler period through early childhood bilingual adolescents. The participants were adolescents from secondary schools from the Slovenian coast and from Trieste. Results show that simultaneousness/successiveness of acquisition of the two languages in question doesn't have any impact on personality traits of tested adolescents.

  17. Simultaneous acute appendicitis and ectopic pregnancy

    OpenAIRE

    Ankouz, Amal; Ousadden, Abdelmalek; Majdoub, Karim Ibn; Chouaib, Ali; Maazaz, Khalid; Taleb, Khalid Ait

    2009-01-01

    The acute abdomen in pregnancy is a surgical emergency. Ectopic pregnancy and appendicitis are two causes of acute abdomen in pregnancy. Difficulties in correctly identifying the cause of the pain can be hazardous to the patient and care needs to be taken in obtaining a prompt and accurate diagnosis enabling the most appropriate management. The case presented here underlies the pathogenesis of the simultaneous existence of these two conditions in a patient.

  18. Simultaneous acute appendicitis and ectopic pregnancy

    Directory of Open Access Journals (Sweden)

    Ankouz Amal

    2009-01-01

    Full Text Available The acute abdomen in pregnancy is a surgical emergency. Ectopic pregnancy and appendicitis are two causes of acute abdomen in pregnancy. Difficulties in correctly identifying the cause of the pain can be hazardous to the patient and care needs to be taken in obtaining a prompt and accurate diagnosis enabling the most appropriate management. The case presented here underlies the pathogenesis of the simultaneous existence of these two conditions in a patient.

  19. Simultaneous Multiple-Location Separation Control

    Science.gov (United States)

    Greenblatt, David (Inventor)

    2009-01-01

    A method of controlling a shear layer for a fluid dynamic body introduces first periodic disturbances into the fluid medium at a first flow separation location. Simultaneously, second periodic disturbances are introduced into the fluid medium at a second flow separation location. A phase difference between the first and second periodic disturbances is adjusted to control flow separation of the shear layer as the fluid medium moves over the fluid dynamic body.

  20. Learning by investing: evidence from a naturally occurring auction

    Czech Academy of Sciences Publication Activity Database

    Hanousek, Jan; Kočenda, Evžen

    2011-01-01

    Roč. 19, č. 1 (2011), s. 125-149 ISSN 0967-0750 R&D Projects: GA ČR GA402/09/1595; GA MŠk LC542 Institutional research plan: CEZ:MSM0021620846 Keywords : learning * naturally occurring auction * stock market Subject RIV: AH - Economics Impact factor: 0.679, year: 2011

  1. Biochemical changes occurring during fermentation of camel milk by ...

    African Journals Online (AJOL)

    hope&shola

    2010-10-25

    Oct 25, 2010 ... The biochemical changes in amino acids, water soluble vitamins, soluble sugars and organic acids occurring during fermentation ... Key words: Camel milk, fermentation, amino acids, organic acids, vitamins, sugars. INTRODUCTION ... milk, growth behavior of some lactic acid bacteria in camel milk and the ...

  2. INTRODUCTION Endocrine disorders do occur among children in ...

    African Journals Online (AJOL)

    INTRODUCTION. Endocrine disorders do occur among children in developing countries, despite the high prevalence of infectious diseases and malnutrition. Reports of endocrine disorders in children in developing countries are few compared to developed countries reflecting the different level of prevalence in the different.

  3. Naturally occurring fatty acids: Source, chemistry, and uses

    Science.gov (United States)

    Natural occurring fatty acids are a large and complex class of compounds found in plants and animals. Fatty acids are abundant and of interest because of their renewability, biodegradability, biocompatibility, low cost, and fascinating chemistry. Of the many fatty acids, only 20-25 of them are widel...

  4. Skin picking disorder with co-occurring body dysmorphic disorder

    DEFF Research Database (Denmark)

    Grant, Jon E; Redden, Sarah A; Leppink, Eric W

    2015-01-01

    There is clinical overlap between skin picking disorder (SPD) and body dysmorphic disorder (BDD), but little research has examined clinical and cognitive correlates of the two disorders when they co-occur. Of 55 participants with SPD recruited for a neurocognitive study and two pharmacological...

  5. Auto-immune Haematological Complications Occurring during the ...

    African Journals Online (AJOL)

    1974-10-19

    Oct 19, 1974 ... Immunohaematological disorders may complicate the clini- cal course of patients with chronic lymphocytic leukaemia, lymphocytic lymphoma and Hodgkin's disease.'" Auto- immune haemolytic anaemia is the most common of these complications, occurring in approximately 10 - 25'% of patients with ...

  6. Co-occurence of Invasive Species on Priority TES Installations

    Science.gov (United States)

    2006-05-01

    Nutrient mineralization rate Nutrient immobilization rate Soil and water chemistry Altered disturbance regime Type ...with installation. Scientific name Scientific name of NIS. Form Life form of NIS. Habitat Habitat type species is most likely to occur in; F... Herbarium , Bruce Baldwin, 510-643-7008 Sea Grant, http://endeavor.des.ucdavis.edu/weeds/countylist.asp California Exotic Pest Plant Council, http

  7. Information disclosure of troubles occurring at Rokkasho Reprocessing Plant

    International Nuclear Information System (INIS)

    Yamada, Tatsuya; Yoneyama, Mitsuru; Shinozaki, Yoshinori

    2005-01-01

    At Rokkasho Reprocessing Plant (RRP), efforts are made so that troubles occurred are promptly reported and announced publicly, and for minor troubles, etc., announcement to the society is made through the web-site and publicity magazines, so as to assure the transparency of the business. (author)

  8. Controlled fermentation of kimchi using naturally occurring antimicrobial agents.

    Science.gov (United States)

    Kim, Jinsol; Bang, Jihyun; Beuchat, Larry R; Kim, Hoikyung; Ryu, Jee-Hoon

    2012-10-01

    Kimchi is a traditional Korean fermented food. Since it ferments continuously during distribution and storage, the extension of shelf life by preventing over-acidification is a major concern in the kimchi industry. One of the most frequently attempted ways to delay fermentation is to add naturally occurring antimicrobial agents. Many researchers have investigated ways to delay over-acidification by adding minor ingredients, fruits or fruit seed extracts, extracts of medicinal herbs, culinary herbs and spices, and other miscellaneous substances to kimchi. The addition of naturally occurring antimicrobial agents may enhance the acceptability of kimchi to consumers over a longer period of time but may also have a disadvantage in that it may cause changes in sensory quality, especially if added in large amounts. To avoid undesirable sensory changes, application of hurdle technologies (i.e., multifactor preservative systems) which involve using combinations of low amounts of various naturally occurring antimicrobial agents as ingredients should be explored with the goal of controlling fermentation. If synergistic or additive antimicrobial effects can be achieved using small amounts of a combination of natural agents, changes in sensory qualities will be minimized, thereby prolonging shelf life. Research findings summarized in this review provide a basis for developing effective hurdle technologies using naturally occurring antimicrobial agents to extend shelf life of kimchi and perhaps other types of traditional fermented foods. Copyright © 2012 Elsevier Ltd. All rights reserved.

  9. Changes occurring in plain, straining and winter yoghurt during the ...

    African Journals Online (AJOL)

    user

    2011-02-28

    Feb 28, 2011 ... Department of Food Engineering, Faculty of Agriculture, Yuzuncu Yil University, 65080 Van, Turkey. Accepted 18 January ... cow milk for production of winter yoghurt, which is one of the most liked traditional .... Changes occurring in winter yoghurt samples during the storage periods. Impact factor. Factor.

  10. Glomus Tumor of Thumb Occurring at Unusual Location

    African Journals Online (AJOL)

    Glomus Tumor of Thumb Occurring at Unusual Location. Samir Dwidmuthe, Amit Nemade, Santhosh Rai1. INTRODUCTION. Wood[1] first described glomus tumors in 1812 as painful subcutaneous tubercles. These are benign tumors that arise from one of the subcutaneous glomus bodies. These account for approximately ...

  11. Acute coronary syndromes occurring while driving: frequency and patient characteristics.

    Science.gov (United States)

    Inamasu, Joji; Miyatake, Satoru; Yagi, Takashi; Noma, Shigetaka

    2017-12-20

    Acute coronary syndrome (ACS) may occur during any human activity, including driving. The objectives of this study were to report the frequency of ACS occurring while driving, clarify patient characteristics, and analyze the behavioral patterns of drivers who sustained ACS. A single-center, retrospective observational study was conducted using prospectively acquired data. Among 1605 ACS patients admitted between January 2011 and December 2016, 65 (60 men/5 women) patients who sustained ACS while driving were identified. Clinical variables were compared between these 65 patients and 1540 patients who sustained ACS while performing other activities. Furthermore, multivariable regression analysis was performed to identify variables associated with ACS. The frequency of ACS occurring while driving was 4.0% (65/1605). Compared with patients who sustained ACS while performing other activities, those who sustained ACS while driving were significantly younger (66.2 ± 13.0 vs. 57.5 ± 12.2 years, p current smoking (OR 1.978; 95% CI 1.145-3.417) were associated with ACS. While 55 drivers (85%) who remained conscious after ACS could seek medical attention without causing accidents, the other 10 (15%) who sustained cardiac arrest caused accidents. The association between current smoking and ACS occurring while driving suggests that smoking cessation is advised for smokers who drive from the standpoint of driving safety. We expect that prospective studies be conducted to verify our findings and identify individuals at risk for ACS while driving.

  12. Right azygos lobe occurring with fissural and lobation anomalies ...

    African Journals Online (AJOL)

    Background: The azygos lobe is a rare anomaly of the lung that is separated from the rest of the upper lobe by an azygos fissure. The lobe is encountered mostly in the right lung but a few cases have also been described in the left lung. It occurs at a frequency of 0.25-1% and has surgical and radiological importance.

  13. Salinity ranges of some southern African fish species occurring in ...

    African Journals Online (AJOL)

    The recorded salinity ranges of 96 fish species occurring in southern African estuaries are documented. Factors influen- cing the tolerance of fishes to low and high salinity regimes are discussed, with most species tolerant of low rather than high salinity conditions. This is important since most systems are subject to periodic ...

  14. The effects of naturally occurring impurities in rock salt

    Indian Academy of Sciences (India)

    To compensate for the small interaction probability [2], a huge volume of detecting material is required, which is found in naturally occurring bulk of dielectrics, such as the ice sheets at the poles or natural salt domes. ..... the salt stock and forms residual accumulation at the dome crest. Other geochemical processes convert ...

  15. The effects of naturally occurring impurities in rock salt

    Indian Academy of Sciences (India)

    In this paper we investigate the effect that naturally occurring impurities in salt mines have both on effective permittivity of ... The effect of trapped water in different forms is also evaluated. Keywords. Effective permittivity; salt ... Thus, salt in salt mines (with a theoretical low dielectric permittivity and high purity) can serve as the ...

  16. The effects of naturally occurring impurities in rock salt

    Indian Academy of Sciences (India)

    In this paper we investigate the effect that naturally occurring impurities in salt mines have both on effective permittivity of the medium and on radio wave propagation at ∼200 MHz. The effective permittivity is determined based on the dielectric properties of salt and the characteristics of the main impurities. We conclude that ...

  17. Adsorption of fluoride ions onto naturally occurring earth materials ...

    African Journals Online (AJOL)

    Batch sorption system using two naturally occurring earth materials (EM) as adsorbents was investigated to remove fluoride ions from aqueous solution. The system variables studied include initial concentration of the sorbate, agitation time, adsorbent dose, pH, co-ions and temperature. The experimental data fitted well to ...

  18. Seroconversion of neurocysticercosis occurring after anti-helminthic treatment.

    Science.gov (United States)

    Dournon, Nathalie; Epelboin, Loic; Brion, Marie-Charlotte; Paris, Luc; Bricaire, François; Caumes, Eric

    2012-12-01

    We report two cases of symptomatic neurocysticercosis in two migrants whose negative serology delayed appropriate treatment for 9 and 6 months, respectively. Seroconversion occurred after treatment, which was associated with paradoxical reaction in one patient. Long-term outcome was good in both patients. © 2012 International Society of Travel Medicine.

  19. Simultaneous multifocal polymorphous low-grade adenocarcinoma. Report of two cases.

    Science.gov (United States)

    Clayton, J R; Pogrel, M A; Regezi, J A

    1995-07-01

    The polymorphous low-grade adenocarcinoma is a recently described variant of salivary gland adenocarcinoma with a comparatively good prognosis. Polymorphous low-grade adenocarcinoma occurs most frequently in the palate with a peak incidence between 30 and 70 years of age. The female/male ratio is approximately 2:1, and the tumors exhibit slow growth with a low recurrence rate. The simultaneous occurrence of polymorphous low-grade adenocarcinoma has not been previously reported. This article reviews the existing literature and describes the first two reports of simultaneous intraoral polymorphous low-grade adenocarcinoma.

  20. Simultaneous bicompartmental bucket handle meniscal tears with a clinically competent Anterior Cruciate Ligament

    Directory of Open Access Journals (Sweden)

    Wright Jonathan

    2010-09-01

    Full Text Available Abstract Bucket handle meniscal tears (BHMT of the knee occur infrequently (approximately 10% of meniscal injuries. Simultaneous, bicompartmental BHMT are extremely rare. Previously, these have only been reported in association with a ruptured anterior cruciate ligament (ACL. The pathomechanism of this injury was thought to be due to the lack of knee stability following the ACL injury. We present a case of a 38 year old male patient with bicompartmental BHMT with a clinically competent ACL. This highlights the need for clinical and radiological suspicion of simultaneous BHMTs even in the presence of an intact ACL.

  1. Parotidectomy with simultaneously reconstruction after surgical defect

    Directory of Open Access Journals (Sweden)

    A. I. Khasanov

    2017-01-01

    Full Text Available Objective: to improve the results of parotidectomy with using the simultaneously reconstruction surgery in the postoperative defects.Background. The radical surgical treatment for salivary gland tumors is parotidectomy with preservation of the facial nerve. However, this treatment leads to postoperative defects and Frey’s syndrome (25 % of cases. Elimination of the above-mentioned disadvantages requires plastic, reconstructive surgery.Materials and methods. In the department of head and neck tumors in the National Cancer Center of Uzbekistan during the period 2015 to 2016 were performed parotidectomy with preservation of the facial nerve and simultaneous retromandibular zone reconstruction with displacing muscle flap in 29 patients. In 25 (86 % patients diagnosed mixed tumor (pleomorphic adenoma and 4 (14 % patients had cancer of parotid gland with the verification of histology.Results. In all of 29 patients were performed parotidectomy with preservation of the facial nerve and the simultaneous reconstruction of retromandibular zone with displacing own bodymuscle flap reduced postoperative complications, which had been revealed before as a defect and hypersensitivity of the retromandibular area.Conclusions. Reconstructive-restorative surgery in patients with tumors in the parotid gland after parotidectomy with saving of the facial nerve is decreased number of cosmetic defect and hypersensitivity. Using the own bodymuscle flap is preferred to patients than allotransplant.

  2. Freeform object design and simultaneous manufacturing

    Science.gov (United States)

    Zhang, Wei; Zhang, Weihan; Lin, Heng; Leu, Ming C.

    2003-04-01

    Today's product design, especially the consuming product design, focuses more and more on individuation, originality, and the time to market. One way to meet these challenges is using the interactive and creationary product design methods and rapid prototyping/rapid tooling. This paper presents a novel Freeform Object Design and Simultaneous Manufacturing (FODSM) method that combines the natural interaction feature in the design phase and simultaneous manufacturing feature in the prototyping phase. The natural interactive three-dimensional design environment is achieved by adopting virtual reality technology. The geometry of the designed object is defined through the process of "virtual sculpting" during which the designer can touch and visualize the designed object and can hear the virtual manufacturing environment noise. During the designing process, the computer records the sculpting trajectories and automatically translates them into NC codes so as to simultaneously machine the designed part. The paper introduced the principle, implementation process, and key techniques of the new method, and compared it with other popular rapid prototyping methods.

  3. Automatic NMR-based identification of chemical reaction types in mixtures of co-occurring reactions.

    Directory of Open Access Journals (Sweden)

    Diogo A R S Latino

    Full Text Available The combination of chemoinformatics approaches with NMR techniques and the increasing availability of data allow the resolution of problems far beyond the original application of NMR in structure elucidation/verification. The diversity of applications can range from process monitoring, metabolic profiling, authentication of products, to quality control. An application related to the automatic analysis of complex mixtures concerns mixtures of chemical reactions. We encoded mixtures of chemical reactions with the difference between the (1H NMR spectra of the products and the reactants. All the signals arising from all the reactants of the co-occurring reactions were taken together (a simulated spectrum of the mixture of reactants and the same was done for products. The difference spectrum is taken as the representation of the mixture of chemical reactions. A data set of 181 chemical reactions was used, each reaction manually assigned to one of 6 types. From this dataset, we simulated mixtures where two reactions of different types would occur simultaneously. Automatic learning methods were trained to classify the reactions occurring in a mixture from the (1H NMR-based descriptor of the mixture. Unsupervised learning methods (self-organizing maps produced a reasonable clustering of the mixtures by reaction type, and allowed the correct classification of 80% and 63% of the mixtures in two independent test sets of different similarity to the training set. With random forests (RF, the percentage of correct classifications was increased to 99% and 80% for the same test sets. The RF probability associated to the predictions yielded a robust indication of their reliability. This study demonstrates the possibility of applying machine learning methods to automatically identify types of co-occurring chemical reactions from NMR data. Using no explicit structural information about the reactions participants, reaction elucidation is performed without structure

  4. Automatic NMR-based identification of chemical reaction types in mixtures of co-occurring reactions.

    Science.gov (United States)

    Latino, Diogo A R S; Aires-de-Sousa, João

    2014-01-01

    The combination of chemoinformatics approaches with NMR techniques and the increasing availability of data allow the resolution of problems far beyond the original application of NMR in structure elucidation/verification. The diversity of applications can range from process monitoring, metabolic profiling, authentication of products, to quality control. An application related to the automatic analysis of complex mixtures concerns mixtures of chemical reactions. We encoded mixtures of chemical reactions with the difference between the (1)H NMR spectra of the products and the reactants. All the signals arising from all the reactants of the co-occurring reactions were taken together (a simulated spectrum of the mixture of reactants) and the same was done for products. The difference spectrum is taken as the representation of the mixture of chemical reactions. A data set of 181 chemical reactions was used, each reaction manually assigned to one of 6 types. From this dataset, we simulated mixtures where two reactions of different types would occur simultaneously. Automatic learning methods were trained to classify the reactions occurring in a mixture from the (1)H NMR-based descriptor of the mixture. Unsupervised learning methods (self-organizing maps) produced a reasonable clustering of the mixtures by reaction type, and allowed the correct classification of 80% and 63% of the mixtures in two independent test sets of different similarity to the training set. With random forests (RF), the percentage of correct classifications was increased to 99% and 80% for the same test sets. The RF probability associated to the predictions yielded a robust indication of their reliability. This study demonstrates the possibility of applying machine learning methods to automatically identify types of co-occurring chemical reactions from NMR data. Using no explicit structural information about the reactions participants, reaction elucidation is performed without structure elucidation of

  5. Mechanism of Simultaneous Tripping of Ground Directional Relays in a 6.6kV Distribution System

    Science.gov (United States)

    Suzuki, Naoto

    In Kyushu Electric Power's 6.6kV distribution system, after a single-phase ground fault occurred in the circuit of a distribution line, we experienced a phenomenon in which the analogue ground directional relays of the other circuits linked to the same bank were simultaneously tripped. In this paper, focus is placed on the mechanism and possibility of simultaneous tripping of ground directional relays. This mechanism was examined in an experiment carried out using an analogue simulator. The results of the test revealed that such simultaneous tripping was attributable to the neutral instability phenomenon of grounding potential transformers installed in an isolated neutral system.

  6. A case of radiation-induced cutaneous angiosarcoma 15 years after simultaneously occurring uterine cervical and gastric cancers discovered by autopsy

    International Nuclear Information System (INIS)

    Okuyama, T.; Enomoto, Yasunori; Yoshikawa, Takafumi; Nonomura, Akitaka; Ichijima, Kunio

    2005-01-01

    A case of cutaneous angiosarcoma in the skin on the left hip previously irradiated for cervical uterine squamous cell carcinoma is discovered by autopsy. The patient, a 79-year-old woman, at age 64 had been then underwent radiotherapy for the cervical uterine carcinoma. A total dose of 50 Gy was administrated. At 79 years of age, she noticed multiple purple black nodular skin lesions on the left hip and thigh. She was hospitalized for 8 days, but her general condition rapidly deteriorated and she died. An autopsy revealed that the skin lesion was composed of atypical polygonal cell proliferation forming irregularly anastomosing vascularity, together with hemorrhage and necrosis. The tumor cells were positive for both CD34 and factor 8-related antigens. The final diagnosis was angiosarcoma. (author)

  7. Chitosan-crosslinked gels prepared by a simultaneously occurring reaction of radiation-induced polymerization and self-bridging of acrylic acid in aqueous solutions

    International Nuclear Information System (INIS)

    Elhag Ali, Amr; Hegazy, Elsayed Ahmed; Hendri, John; Katakai, Ryoichi; Maekawa, Yasunari; Kume, Tamikazu; Yoshida, Masaru

    2001-01-01

    Chitosan is one of the most interesting natural polymers, in addition to its biodegradability it shows wide biological properties such as antifibrolastic and antimicrobial activities, which verify its biomedical application. Novel Acrylic acid/Chitosan hydrogel was prepared by means of γ-irradiation as a clean source for initiation, and crosslinking. The nature of the AAc/CS gel and the effect of the presence of chitosan on the behavior of AAc were characterized. The effect of pH on the degree of swelling of different gels and time course swelling studies show the effect of presence of chitosan and its molecular weight on the swelling of the gels. DSC and TGA were used to study the effect of the presence of chitosan on the thermal behavior of PAAc. It was found that chitosan change thermal behavior of AAc. These results support our assumption for the formation of crosslinking between PAAc and CS chains via polyelectrolyte complex formation, attributed to the high affinity between CS and AAc, accompanied by homopolymerization and self-bridging. This crosslinking increase with CS molecular weight increasing and affect the thermal behavior of PAAc. (author)

  8. Paroxysmal atrial fibrillation occurs often in cryptogenic ischaemic stroke

    DEFF Research Database (Denmark)

    Christensen, L M; Krieger, D W; Højberg, S

    2014-01-01

    lasting predominantly between 1 and 4 h. Four recurrent strokes were observed, three in patients with PAF; all three patients were on oral anticoagulation (OAC). CONCLUSIONS: One in five patients with CS had PAF, which occurred at low burden and long after stroke. Future studies should determine the role......BACKGROUND AND PURPOSE: Atrial fibrillation (AF) increases the risk of stroke fourfold and is associated with a poor clinical outcome. Despite work-up in compliance with guidelines, up to one-third of patients have cryptogenic stroke (CS). The prevalence of asymptomatic paroxysmal atrial...... patients (16.1%). In three patients PAF was detected by other methods before or after monitoring and was undiscovered due to device sensitivity in one case. The first event of PAF was documented at a mean of 109 days (SD ±48) after stroke onset. PAF was asymptomatic in all cases and occurred in episodes...

  9. Combinations of Genetic Variants Occurring Exclusively in Patients

    Directory of Open Access Journals (Sweden)

    Erling Mellerup

    2017-01-01

    Full Text Available In studies of polygenic disorders, scanning the genetic variants can be used to identify variant combinations. Combinations that are exclusively found in patients can be separated from those combinations occurring in control persons. Statistical analyses can be performed to determine whether the combinations that occur exclusively among patients are significantly associated with the investigated disorder. This research strategy has been applied in materials from various polygenic disorders, identifying clusters of patient-specific genetic variant combinations that are significant associated with the investigated disorders. Combinations from these clusters are found in the genomes of up to 55% of investigated patients, and are not present in the genomes of any control persons.

  10. Mechanism of prion propagation: amyloid growth occurs by monomer addition.

    Directory of Open Access Journals (Sweden)

    Sean R Collins

    2004-10-01

    Full Text Available Abundant nonfibrillar oligomeric intermediates are a common feature of amyloid formation, and these oligomers, rather than the final fibers, have been suggested to be the toxic species in some amyloid diseases. Whether such oligomers are critical intermediates for fiber assembly or form in an alternate, potentially separable pathway, however, remains unclear. Here we study the polymerization of the amyloidogenic yeast prion protein Sup35. Rapid polymerization occurs in the absence of observable intermediates, and both targeted kinetic and direct single-molecule fluorescence measurements indicate that fibers grow by monomer addition. A three-step model (nucleation, monomer addition, and fiber fragmentation accurately accounts for the distinctive kinetic features of amyloid formation, including weak concentration dependence, acceleration by agitation, and sigmoidal shape of the polymerization time course. Thus, amyloid growth can occur by monomer addition in a reaction distinct from and competitive with formation of potentially toxic oligomeric intermediates.

  11. Naturally occurring tumours in the basal metazoan Hydra.

    Science.gov (United States)

    Domazet-Lošo, Tomislav; Klimovich, Alexander; Anokhin, Boris; Anton-Erxleben, Friederike; Hamm, Mailin J; Lange, Christina; Bosch, Thomas C G

    2014-06-24

    The molecular nature of tumours is well studied in vertebrates, although their evolutionary origin remains unknown. In particular, there is no evidence for naturally occurring tumours in pre-bilaterian animals, such as sponges and cnidarians. This is somewhat surprising given that recent computational studies have predicted that most metazoans might be prone to develop tumours. Here we provide first evidence for naturally occurring tumours in two species of Hydra. Histological, cellular and molecular data reveal that these tumours are transplantable and might originate by differentiation arrest of female gametes. Growth of tumour cells is independent from the cellular environment. Tumour-bearing polyps have significantly reduced fitness. In addition, Hydra tumours show a greatly altered transcriptome that mimics expression shifts in vertebrate cancers. Therefore, this study shows that spontaneous tumours have deep evolutionary roots and that early branching animals may be informative in revealing the fundamental mechanisms of tumorigenesis.

  12. Talon cusps occurring concurrently with dens invaginatus on a permanent maxillary lateral incisor: a case report and literature review.

    Science.gov (United States)

    Colak, Hakan; Yilmaz, Cicek; Keklik, Hakan; Colak, Tugba

    2014-01-01

    A talon cusp is a prominent accessory horn-like structure that projects from the cingulum or cementoenamel junction of the maxillary or mandibular teeth. It can occur in primary and permanent dentition and can lead to occlusal interference, irritation of the tongue, pulpal necrosis, caries, and periodontal problems. Talon cusp has been reported to affect both sexes, and may be unilateral or bilateral. Talon cusps occur most often on the palatal surface of permanent maxillary incisors. A comprehensive literature review revealed only 6 reported cases of facial talon cusps. A talon cusp occurring simultaneously with dens invaginatus in a tooth is extremely rare; to date, only 9 case reports have been published. This article presents a unique case of concurrent dens invaginatus and palatal and facial talon cusps in the right maxillary central incisor of a 12-year-old girl.

  13. Naturally occurring mutations in the canine CFTR gene

    OpenAIRE

    Spadafora, Domenico; Hawkins, Eleanor C.; Murphy, Keith E.; Clark, Leigh Anne; Ballard, Stephen T.

    2010-01-01

    Naturally occurring cystic fibrosis (CF)-causing mutations in the CFTR gene have not been identified in any nonhuman animal species. Since domestic dogs are known to develop medical conditions associated with atypical CF in humans (e.g., bronchiectasis and pancreatitis), we hypothesized that dogs with these disorders likely have a higher expression rate of CFTR mutations than the at-large population. Temporal temperature-gradient gel electrophoresis (TTGE) was used to screen canine CFTR in 40...

  14. Probiotic properties of yeasts occurring in fermented food and beverages

    DEFF Research Database (Denmark)

    Jespersen, Lene

    Besides being able to improve the quality and safety of many fermented food and beverages some yeasts offer a number of probiotic traits. Especially a group of yeast referred to as "Saccharomyces boulardii", though taxonomically belonging to Saccharomyces cerevisiae, has been claimed to have...... probiotic properties. Besides, yeasts naturally occurring globally in food and beverages will have traits that might have a positive impact on human health....

  15. Late occurring ectopic pregnancy in a posthysterectomy patient.

    Science.gov (United States)

    Anis, Munazza; Irshad, Abid; Ackerman, Susan

    2013-01-01

    The incidence of ectopic pregnancy after hysterectomy is extremely rare with only 56 cases reported in the medical literature. Due to its rare occurrence, this diagnosis may not be initially considered when such a patient presents with abdominopelvic pain. It is an important diagnosis to keep in mind since a delay in diagnosis may lead to death. The case presented below describes this extremely unusual diagnosis of an ectopic pregnancy which occurred six years after a supracervical hysterectomy.

  16. Case of basal cell epithelioma occurring on chronic radiation dermatitis

    Energy Technology Data Exchange (ETDEWEB)

    Kase, Kayoko; Matsuoka, Yoshitaka; Urushibata, Osamu; Nishiwaki, Soichi (Toho Univ. Ohashi Hosp., Tokyo (Japan))

    1989-05-01

    A 52-year-old woman had been treated with radiation therapy for lymphoid tuberculosis on the right side of the neck 40 years before. Chronic radiation dermatitis occurred on that site. Blackish small mass has appeared 2 years before on the central part of the dermatitis. Histological examination revealed thinning of the epidermis, swelling of the dermal collagen fibers, and follicular clusters composed of basaloid cells from the epidermis to the upper layer of the dermis. (Namekawa, K).

  17. Lichen striatus occurring after a tetanus vaccine: A case report

    OpenAIRE

    Ayşegül Yalçınkaya İyidal; Kadir Balaban; Arzu Kılıç

    2017-01-01

    Lichen striatus (LS) is an uncommon, acquired, self-limiting, linear inflammatory dermatosis. The eruption typically presents as pink or tan papules along Blaschko’s lines. It usually occurs in children, rarely affects adults. The rashes usually suddenly emerge in a single extremity and may regress within a few months or years. The incidence is slightly higher among women. The etiology of LS is not exactly known, however, it is thought to be a T cell-mediated autoimmune reaction. Trauma, infe...

  18. A Stochastical Model for the Earthquake Occurences in Turkey

    Directory of Open Access Journals (Sweden)

    Gamze ÖZEL

    2009-04-01

    Full Text Available The fields of seismology and earthquake engineering deal with the studies for earthquake predictions, hazard assessments and the prevention of possible damage due to destructive earthquakes. Various kind of statistical models are used for the earthquake occurences. The most familiar model is a Poisson process for random series of events. However, the Poisson process is insufficient if the incorporation of more information about the seismic process is required. Recently, a compound Poisson process has been proposed an alternative to the Poisson process for the earthquake analysis. In this study, the compound Poisson process is introduced and the probabilities of earthquake numbers with magnitude M ³ 5.0 which will occur within 3 and 6 months; 5 and 10 years have been obtained for Turkey from the Poisson process. Then, it is shown that the aftershock sequences follow a geometric distribution. By this way, the probabilities of total number of aftershocks which will occur within one year and two years with magnitude M ³ 4.0 in Turkey are obtained from the compound Poisson process. Finally, the expected values of main shocks and total number of aftershocks which will occur within one year and two years are computed. The results show that the earthquake occurrence probability with magnitude M ³ 5.0 increases, whereas the probability of total number of aftershocks with magnitude M ³ 4.0 decreases in Turkey as the time increases. Besides, the total aftershock number with magnitude M ³ 4.0 , after a main shock with magnitude M ³ 5.0, equals to zero with the probability 0.48 within one year. The findings also indicate that approximately 130 main shocks with M ³ 5.0 , 28 aftershocks with magnitude M ³ 4.0 are expected within 30 years in Turkey.

  19. Sensory-motor transformations for speech occur bilaterally.

    Science.gov (United States)

    Cogan, Gregory B; Thesen, Thomas; Carlson, Chad; Doyle, Werner; Devinsky, Orrin; Pesaran, Bijan

    2014-03-06

    Historically, the study of speech processing has emphasized a strong link between auditory perceptual input and motor production output. A kind of 'parity' is essential, as both perception- and production-based representations must form a unified interface to facilitate access to higher-order language processes such as syntax and semantics, believed to be computed in the dominant, typically left hemisphere. Although various theories have been proposed to unite perception and production, the underlying neural mechanisms are unclear. Early models of speech and language processing proposed that perceptual processing occurred in the left posterior superior temporal gyrus (Wernicke's area) and motor production processes occurred in the left inferior frontal gyrus (Broca's area). Sensory activity was proposed to link to production activity through connecting fibre tracts, forming the left lateralized speech sensory-motor system. Although recent evidence indicates that speech perception occurs bilaterally, prevailing models maintain that the speech sensory-motor system is left lateralized and facilitates the transformation from sensory-based auditory representations to motor-based production representations. However, evidence for the lateralized computation of sensory-motor speech transformations is indirect and primarily comes from stroke patients that have speech repetition deficits (conduction aphasia) and studies using covert speech and haemodynamic functional imaging. Whether the speech sensory-motor system is lateralized, like higher-order language processes, or bilateral, like speech perception, is controversial. Here we use direct neural recordings in subjects performing sensory-motor tasks involving overt speech production to show that sensory-motor transformations occur bilaterally. We demonstrate that electrodes over bilateral inferior frontal, inferior parietal, superior temporal, premotor and somatosensory cortices exhibit robust sensory-motor neural

  20. Naturally Occurring Anthraquinones: Chemistry and Therapeutic Potential in Autoimmune Diabetes

    Directory of Open Access Journals (Sweden)

    Shih-Chang Chien

    2015-01-01

    Full Text Available Anthraquinones are a class of aromatic compounds with a 9,10-dioxoanthracene core. So far, 79 naturally occurring anthraquinones have been identified which include emodin, physcion, cascarin, catenarin, and rhein. A large body of literature has demonstrated that the naturally occurring anthraquinones possess a broad spectrum of bioactivities, such as cathartic, anticancer, anti-inflammatory, antimicrobial, diuretic, vasorelaxing, and phytoestrogen activities, suggesting their possible clinical application in many diseases. Despite the advances that have been made in understanding the chemistry and biology of the anthraquinones in recent years, research into their mechanisms of action and therapeutic potential in autoimmune disorders is still at an early stage. In this paper, we briefly introduce the etiology of autoimmune diabetes, an autoimmune disorder that affects as many as 10 million worldwide, and the role of chemotaxis in autoimmune diabetes. We then outline the chemical structure and biological properties of the naturally occurring anthraquinones and their derivatives with an emphasis on recent findings about their immune regulation. We discuss the structure and activity relationship, mode of action, and therapeutic potential of the anthraquinones in autoimmune diabetes, including a new strategy for the use of the anthraquinones in autoimmune diabetes.

  1. The Functions and Longitudinal Outcomes of Adolescents' Naturally Occurring Mentorships.

    Science.gov (United States)

    Miranda-Chan, Thomas; Fruiht, Veronica; Dubon, Valeska; Wray-Lake, Laura

    2016-03-01

    Adolescence is a time during which positive adults outside the familial context may be most influential to development. A growing body of research on naturally occurring mentors has found favorable outcomes for youth who have these types of positive adult figures in their lives. Less is known, however, about how these naturally occurring mentors influence youths' development in the long-term. This study examines the long-term outcomes related to having a naturally occurring community mentor in adolescence. Results from longitudinal analyses of a nationally representative sample of adolescents revealed that having a mentor in adolescence was related to higher educational attainment, lower criminal activity, higher psychological well-being (i.e., optimism, self-efficacy, and lack of depressive symptoms), and greater romantic relationship satisfaction in adulthood. Additionally, a taxonomy of mentoring functions was created from qualitative responses and drawing upon the youth, work, and academic mentoring literature. This taxonomy aims to serve as a framework for understanding the functions of youth mentors to provide a foundation for future research. Implications of findings and future directions are considered. © Society for Community Research and Action 2016.

  2. Natural transformation of Campylobacter jejuni occurs beyond limits of growth.

    Science.gov (United States)

    Vegge, Christina S; Brøndsted, Lone; Ligowska-Marzęta, Małgorzata; Ingmer, Hanne

    2012-01-01

    Campylobacter jejuni is a human bacterial pathogen. While poultry is considered to be a major source of food borne campylobacteriosis, C. jejuni is frequently found in the external environment, and water is another well-known source of human infections. Natural transformation is considered to be one of the main mechanisms for mediating transfer of genetic material and evolution of the organism. Given the diverse habitats of C. jejuni we set out to examine how environmental conditions and physiological processes affect natural transformation of C. jejuni. We show that the efficiency of transformation is correlated to the growth conditions, but more importantly that transformation occurs at growth-restrictive conditions as well as in the late stationary phase; hence revealing that growth per se is not required for C. jejuni to be competent. Yet, natural transformation of C. jejuni is an energy dependent process, that occurs in the absence of transcription but requires an active translational machinery. Moreover, we show the ATP dependent ClpP protease to be important for transformation, which possibly could be associated with reduced protein glycosylation in the ClpP mutant. In contrast, competence of C. jejuni was neither found to be involved in DNA repair following DNA damage nor to provide a growth benefit. Kinetic studies revealed that several transformation events occur per cell cycle indicating that natural transformation of C. jejuni is a highly efficient process. Thus, our findings suggest that horizontal gene transfer by natural transformation takes place in various habitats occupied by C. jejuni.

  3. Hepatitis B Virus Capsid Completion Occurs through Error Correction.

    Science.gov (United States)

    Lutomski, Corinne A; Lyktey, Nicholas A; Zhao, Zhongchao; Pierson, Elizabeth E; Zlotnick, Adam; Jarrold, Martin F

    2017-11-22

    Understanding capsid assembly is important because of its role in virus lifecycles and in applications to drug discovery and nanomaterial development. Many virus capsids are icosahedral, and assembly is thought to occur by the sequential addition of capsid protein subunits to a nucleus, with the final step completing the icosahedron. Almost nothing is known about the final (completion) step because the techniques usually used to study capsid assembly lack the resolution. In this work, charge detection mass spectrometry (CDMS) has been used to track the assembly of the T = 4 hepatitis B virus (HBV) capsid in real time. The initial assembly reaction occurs rapidly, on the time scale expected from low resolution measurements. However, CDMS shows that many of the particles generated in this process are defective and overgrown, containing more than the 120 capsid protein dimers needed to form a perfect T = 4 icosahedron. The defective and overgrown capsids self-correct over time to the mass expected for a perfect T = 4 capsid. Thus, completion is a distinct phase in the assembly reaction. Capsid completion does not necessarily occur by inserting the last building block into an incomplete, but otherwise perfect icosahedron. The initial assembly reaction can be predominently imperfect, and completion involves the slow correction of the accumulated errors.

  4. Role of human Toll-like receptors in naturally occurring influenza A infections.

    Science.gov (United States)

    Lee, Nelson; Wong, Chun Kwok; Hui, David S C; Lee, Sharon K W; Wong, Rity Y K; Ngai, Karry L K; Chan, Martin C W; Chu, Yi Jun; Ho, Amy W Y; Lui, Grace C Y; Wong, Bonnie C K; Wong, Sunny H; Yip, Shea Ping; Chan, Paul K S

    2013-09-01

    We investigated the roles of Toll-like receptors (TLRs) in naturally occurring influenza. A prospective, case - control study was conducted. Adults hospitalized with virologically confirmed influenza A infections (onset respiratory/cardiovascular complications. There were increased cellular expressions of TLR9, TLR8, TLR3, and TLR7 during influenza; TLR2 and TLR4 were suppressed. Results were similar for both virus strains. Higher TLR expression levels at presentation significantly correlated with lower viral loads (Spearman's rho: -0.46 to -0.69 for TLR9, TLR8, and TLR3; P-values <0.05). Multivariate regression models (adjusted for age, comorbidity, disease severity, time from onset) confirmed their independent associations. Increased signaling molecules (phospho-MAPKs, IκB) and inflammatory cytokines (IL-6, sTNFR-1, CCL2/MCP-1; CXCL10/IP-10, IFN-γ) correlated with increased TLR expression. RLRs were upregulated simultaneously. PBMCs of patients with influenza showed significant, dynamic changes in their cytokine responses upon TLR stimulation, compared with controls. Our results suggest that TLRs play an important role in early, innate viral inhibition in naturally occurring influenza. Inflammatory cytokine responses are concomitantly induced. These findings support investigation of TLR targeting as a novel intervention approach for prophylaxis against influenza. © 2013 John Wiley & Sons Ltd.

  5. Risk factors for dog bites occurring during and outside of play: are they different?

    Science.gov (United States)

    Messam, Locksley L McV; Kass, Philip H; Chomel, Bruno B; Hart, Lynette A

    2012-11-01

    some of the examined factors are associated with increased frequencies of both types of bites, this could explain high percentages of bites occurring during play with the dog as reported in various case series of dog bites. If so, dog bite prevention strategies targeting these factors will simultaneously reduce the incidence of both types of bites. Copyright © 2012 Elsevier B.V. All rights reserved.

  6. Simultaneous Periprosthetic Fractures of the Femur and the Acetabulum After Bipolar Hip Arthroplasty.

    Science.gov (United States)

    Verettas, Dionysios-Alexandros; Chloropoulou, Pelagia-Paraskevi; Drosos, Georgios; Vogiatzaki, Theodosia; Tilkeridis, Konstantinos; Kazakos, Konstantinos

    2016-12-22

    BACKGROUND Although periprosthetic fractures of the femur are a recognized complication of total hip arthroplasty, periprosthetic fractures of the acetabulum are rare. Simultaneous periprosthetic fractures of both the acetabulum and the femur have not been reported, to our knowledge. CASE REPORT We report a simultaneous fracture of the acetabulum and the femur in a 68-year-old female patient who had previously sustained a subcapital fracture of the femur, treated with a bipolar uncemented prosthesis. We discuss the possible mechanism of this combination of fractures. CONCLUSIONS Simultaneous periprosthetic fractures of the femur and the acetabulum can occur if, in the presence of osteoporotic bone, the metallic femoral head has migrated medially in the acetabulum while the femoral stem is not loose.

  7. Long-term music training modulates the recalibration of audiovisual simultaneity.

    Science.gov (United States)

    Jicol, Crescent; Proulx, Michael J; Pollick, Frank E; Petrini, Karin

    2018-04-23

    To overcome differences in physical transmission time and neural processing, the brain adaptively recalibrates the point of simultaneity between auditory and visual signals by adapting to audiovisual asynchronies. Here, we examine whether the prolonged recalibration process of passively sensed visual and auditory signals is affected by naturally occurring multisensory training known to enhance audiovisual perceptual accuracy. Hence, we asked a group of drummers, of non-drummer musicians and of non-musicians to judge the audiovisual simultaneity of musical and non-musical audiovisual events, before and after adaptation with two fixed audiovisual asynchronies. We found that the recalibration for the musicians and drummers was in the opposite direction (sound leading vision) to that of non-musicians (vision leading sound), and change together with both increased music training and increased perceptual accuracy (i.e. ability to detect asynchrony). Our findings demonstrate that long-term musical training reshapes the way humans adaptively recalibrate simultaneity between auditory and visual signals.

  8. Simultaneous neutron and gamma spectrum adjustment

    International Nuclear Information System (INIS)

    Remec, I.

    1996-01-01

    The spectrum adjustment procedure was extended to simultaneous neutron and gamma spectrum adjustment, and the feasibility of this technique is demonstrated in the analysis of HFIR dosimetry experiments. Conditions in which gamma rays may contribute considerably to radiation damage in steels are discussed. Beryllium helium accumulation fluence monitors (HAFMs) were found to be good monitors in gamma fields of intensities high enough to contribute to steel embrittlement. Use of 237 Np, 238 U, and 9 Be HAFM as gamma dosimeters is proposed for high-dose irradiations in high-energy, high-intensity gamma fields

  9. Simultaneous scheduling of machines and mobile robots

    DEFF Research Database (Denmark)

    Dang, Vinh Quang; Nielsen, Izabela Ewa

    2013-01-01

    This paper deals with the problem of simultaneously scheduling machines and a number of autonomous mobile robots in a flexible manufacturing system (FMS). Besides capability of transporting materials between machines, the considered mobile robots are different from other material handling devices...... in terms of their advanced ability to perform tasks at machines by using their manipulation arms. The mobile robots thus have to be scheduled in relation to scheduling of machines so as to increase the efficiency of the overall system. The performance criterion is to minimize time required to complete all...

  10. Focusing on Concepts by Covering Them Simultaneously

    Science.gov (United States)

    Schwartz, Pete

    2017-05-01

    "Parallel" pedagogy covers the four mechanics concepts of momentum, energy, forces, and kinematics simultaneously instead of building each concept on an understanding of the previous one. Course content is delivered through interactive videos, allowing class time for group work and student-centered activities. We start with simple examples, building complexity throughout the course with the introduction of springs, two dimensions, vectors, energy diagrams, universal gravitation, and rotation. Success means that students ponder underlying physics concepts rather than hunt for formulas. Surveys indicate that students accept this learning model well and have considerable improvement in applied conceptual understanding.

  11. Simultaneous distribution of AC and DC power

    Science.gov (United States)

    Polese, Luigi Gentile

    2015-09-15

    A system and method for the transport and distribution of both AC (alternating current) power and DC (direct current) power over wiring infrastructure normally used for distributing AC power only, for example, residential and/or commercial buildings' electrical wires is disclosed and taught. The system and method permits the combining of AC and DC power sources and the simultaneous distribution of the resulting power over the same wiring. At the utilization site a complementary device permits the separation of the DC power from the AC power and their reconstruction, for use in conventional AC-only and DC-only devices.

  12. Chemical reactions occurring during direct solar reduction of CO2.

    Science.gov (United States)

    Lyma, J L; Jensen, R J

    2001-09-28

    At high temperatures carbon dioxide may absorb solar radiation and react to form carbon monoxide and molecular oxygen. The CO, so produced, may be converted by well-established means to a combustible fuel, such as methanol. We intend to make a future demonstration of the solar reduction of CO2 based on these processes. This paper, however, addresses only the problem of preserving, or even enhancing, the initial photolytic CO by quenching the hot gas with colder H2O or CO2. We present model calculations with a reaction mechanism used extensively in other calculations. If a CO2 gas stream is heated and photolyzed by intense solar radiation and then allowed to cool slowly, it will react back to the initial CO2 by a series of elementary chemical reactions. The back reaction to CO2 can be terminated with the rapid addition of CO2, water, or a mixture. Calculations show that a three-fold quench with pure CO2 will stop the reactions and preserve over 90% of the initial photolytic CO. We find that water has one of two effects. It can either increase the CO level, or it can catalyze the recombination of O and CO to CO2. The gas temperature is the determining factor. If the quench gas is not sufficient to keep the temperature below approximately 1100 K, a chain-branching reaction dominates and the reaction to CO2 occurs. If the temperature stays below that level a chain terminating reaction dominates and the CO is increased. The former case occurs below approximately a fourfold quench with a water/CO2 mixture. The later case occurs when the quench is greater than fourfold. We conclude that CO2, H2O, or a mixture may quench the hot gas stream photolyzed by solar radiation and preserve the photolytic CO.

  13. Leaching Properties of Naturally Occurring Heavy Metals from Soils

    Science.gov (United States)

    Zhang, M.; Hoshino, M.; Yoshikawa, M.; Hara, J.; Sugita, H.

    2014-12-01

    The major threats to human health from heavy metals are associated with exposure to arsenic, lead, cadmium, chromium, mercury, as well as some other elements. The effects of such heavy metals on human health have been extensively studied and reviewed by international organizations such as WHO. Due to their toxicity, heavy metal contaminations have been regulated by national environmental standards in many countries, and/or laws such as the Soil Contamination Countermeasures Act in Japan. Leaching of naturally occurring heavy metals from the soils, especially those around abandoned metal mines into surrounding water systems, either groundwater or surface water systems, is one of the major pathways of exposure. Therefore, understanding the leaching properties of toxic heavy metals from naturally polluted soils is of fundamentally importance for effectively managing abandoned metal mines, excavated rocks discharged from infrastructure constructions such as tunneling, and/or selecting a pertinent countermeasure against pollution when it is necessary. In this study, soil samples taken from the surroundings of abandoned metal mines in different regions in Japan were collected and analyzed. The samples contained multiple heavy metals such as lead, arsenic and chromium. Standard leaching test and sequential leaching test considering different forms of contaminants, such as trivalent and pentavalent arsenics, and trivalent and hexavalent chromiums, together with standard test for evaluating total concentration, X-ray Fluorescence Analysis (XRF), X-ray diffraction analysis (XRD) and Cation Exchange Capacity (CEC) tests were performed. In addition, sequential leaching tests were performed to evaluate long-term leaching properties of lead from representative samples. This presentation introduces the details of the above experimental study, discusses the relationships among leaching properties and chemical and mineral compositions, indicates the difficulties associated with

  14. Chemical reactions occurring during direct solar reduction of CO2

    International Nuclear Information System (INIS)

    Lyman, J.L.; Jensen, R.J.

    2001-01-01

    At high temperatures carbon dioxide may absorb solar radiation and react to form carbon monoxide and molecular oxygen. The CO so produced, may be converted by well-established means to a combustible fuel, such as methanol. We intend to make a future demonstration of the solar reduction of CO 2 based on these processes. This paper, however, addresses only the problem of preserving, or even enhancing, the initial photolytic CO by quenching the hot gas with colder H 2 O or CO 2 . We present model calculations with a reaction mechanism used extensively in other calculations. If a CO 2 gas stream is heated and photolyzed by intense solar radiation and then allowed to cool slowly, it will react back to the initial CO 2 by a series of elementary chemical reactions. The back reaction to CO 2 can be terminated with the rapid addition of CO 2 , water, or a mixture. Calculations show that a three-fold quench with pure CO 2 will stop the reactions and preserve over 90% of the initial photolytic CO. We find that water has one of two effects. It can either increase the CO level, or it can catalyze the recombination of O and CO to CO 2 . The gas temperature is the determining factor. If the quench gas is not sufficient to keep the temperature below approximately 1100 K, a chain-branching reaction dominates and the reaction to CO 2 occurs. If the temperature stays below that level a chain terminating reaction dominates and the CO is increased. The former case occurs below approximately a fourfold quench with a water/CO 2 mixture. The later case occurs when the quench is greater than fourfold. We conclude that CO 2 , H 2 O, or a mixture may quench the hot gas stream photolyzed by solar radiation and preserve the photolytic CO

  15. Natural transformation of Campylobacter jejuni occurs beyond limits of growth.

    Directory of Open Access Journals (Sweden)

    Christina S Vegge

    Full Text Available Campylobacter jejuni is a human bacterial pathogen. While poultry is considered to be a major source of food borne campylobacteriosis, C. jejuni is frequently found in the external environment, and water is another well-known source of human infections. Natural transformation is considered to be one of the main mechanisms for mediating transfer of genetic material and evolution of the organism. Given the diverse habitats of C. jejuni we set out to examine how environmental conditions and physiological processes affect natural transformation of C. jejuni. We show that the efficiency of transformation is correlated to the growth conditions, but more importantly that transformation occurs at growth-restrictive conditions as well as in the late stationary phase; hence revealing that growth per se is not required for C. jejuni to be competent. Yet, natural transformation of C. jejuni is an energy dependent process, that occurs in the absence of transcription but requires an active translational machinery. Moreover, we show the ATP dependent ClpP protease to be important for transformation, which possibly could be associated with reduced protein glycosylation in the ClpP mutant. In contrast, competence of C. jejuni was neither found to be involved in DNA repair following DNA damage nor to provide a growth benefit. Kinetic studies revealed that several transformation events occur per cell cycle indicating that natural transformation of C. jejuni is a highly efficient process. Thus, our findings suggest that horizontal gene transfer by natural transformation takes place in various habitats occupied by C. jejuni.

  16. Breaking the bad news when sudden death occurs.

    Science.gov (United States)

    Von Bloch, L

    1996-01-01

    Notification of family when sudden death has occurred is often a highly stressful experience for hospital Emergency Department physicians and nursing personnel. This article will offer some guidelines to health care professionals in helping a deceased patient's family cope with the initial grief and loss that accompanies the unexpected death of a loved one. At the same time, an understanding of the wide range of emotional responses of bereaved survivors may case some of the anxiety Emergency Department staff members associate with "breaking the bad news."

  17. Occurence of Puccinia bornmuelleri Magnus in the Czech Republic

    Directory of Open Access Journals (Sweden)

    Jiří Müller

    2007-01-01

    Full Text Available Rust on Levisticum officinale was found on the foothill of “Velká Baba“ Hill north-west of Brno-Řečkovice on May 2006. It was identifity as Puccinia bornmuelleri Magnus. On the leaves there were a lot of uredinia and one group of spermogonia. The telia was found in September 2006. Probably, the rust occurs on more locations in Brno. The rust was found in Rumania a few years ago. These are the first two findings in Europe. The rust comes from Iran and Afghanistan. Spermogonia have been found together with uredia therefore P. bornmuelleri is brachypuccinia.

  18. A Summertime Severe Weather Event Occurring in the Taipei Basin

    Directory of Open Access Journals (Sweden)

    George Tai-Jen Chen Hung-Chi Chou

    2006-01-01

    Full Text Available A case of summertime strong convection occurring on 29 August 1999, producing hail and strong gusts in the Taipei Basin, was studied using conventional and Doppler radar data. Results showed that an upper-level cold vortex to the east of Taiwan provided strong vertical wind shear and increased potential instability favorable for the development of strong convection. Drying of the mid-troposphere was primarily responsible for the strong gusts as mid-level dry air entered the system and caused strong evaporative cooling.

  19. Iliac arterial-enteric fistulas occurring after pelvic irradiation

    International Nuclear Information System (INIS)

    Vetto, J.T.; Culp, S.C.; Smythe, T.B.; Chang, A.E.; Sindelar, W.F.; Sugarbaker, P.H.; Heit, H.A.; Giordano, J.M.; Kozloff, L.

    1987-01-01

    Fistulas from the iliac artery to the bowel constitute a condition that is often lethal. Excluding fistulas related to vascular grafts, a review of previously reported cases shows that they are most often due to atherosclerotic iliac aneurysms. Three unusual cases of this condition that occurred after high-dose pelvic irradiation for treatment of cancer are presented; in no case was recurrent tumor evident. These cases suggest that high-dose pelvic irradiation can predispose to the formation of iliac arterial-enteric fistulas, particularly if sepsis or inflammation develops. The definitive surgical management of these fistulas entails bowel resection, arterial ligation, and extra-anatomic bypass

  20. A case report of osteosarcoma occurred in the maxilla

    International Nuclear Information System (INIS)

    Jung, Yun Hwa; Jeon, Seon Doo

    1996-01-01

    Osteosarcoma is the most common malignant tumor of bone, The mean age of occurrence of osteosarcoma in the jaws is around 30, somewhat older than for other sites in the body. These lesions occur about equally in the maxilla and mandible. They most frequently develop in the body in the mandible, and the antrum and the posterior portion of alveolar ridge in the maxilla. We report a case of osteosarcoma in 35 years old female complaining swelling of the left cheek. Radiographic features showed cotton wool appearance in upper left posterior area. Histopathologic findings exhibited pleomorphic malignant osteoblasts and neoplastic osteoid.

  1. Naturally occurring crystalline phases: analogues for radioactive waste forms

    International Nuclear Information System (INIS)

    Haaker, R.F.; Ewing, R.C.

    1981-01-01

    Naturally occurring mineral analogues to crystalline phases that are constituents of crystalline radioactive waste forms provide a basis for comparison by which the long-term stability of these phases may be estimated. The crystal structures and the crystal chemistry of the following natural analogues are presented: baddeleyite, hematite, nepheline; pollucite, scheelite;sodalite, spinel, apatite, monazite, uraninite, hollandite-priderite, perovskite, and zirconolite. For each phase in geochemistry, occurrence, alteration and radiation effects are described. A selected bibliography for each phase is included

  2. Naturally occurring crystalline phases: analogues for radioactive waste forms

    Energy Technology Data Exchange (ETDEWEB)

    Haaker, R.F.; Ewing, R.C.

    1981-01-01

    Naturally occurring mineral analogues to crystalline phases that are constituents of crystalline radioactive waste forms provide a basis for comparison by which the long-term stability of these phases may be estimated. The crystal structures and the crystal chemistry of the following natural analogues are presented: baddeleyite, hematite, nepheline; pollucite, scheelite;sodalite, spinel, apatite, monazite, uraninite, hollandite-priderite, perovskite, and zirconolite. For each phase in geochemistry, occurrence, alteration and radiation effects are described. A selected bibliography for each phase is included.

  3. Complexes of actinides with naturally occuring organic substances - Literature survey

    International Nuclear Information System (INIS)

    Olofsson, U.; Allard, B.

    1983-02-01

    Properties of naturally occurring humic and fulvic acids and their formation of actinide complexes are reviewed. Actinides in all the oxdation states III, IV, V and VI would form complexes with many humic and fulvic acids, comparable in strength to the hydroxide and carbonate complexes. Preliminary experiments have shown, that the presence of predominantly humic acid complexes would significantly reduce the sorption of americium on geologic media. This does not, however, necessarily lead to a potentially enhanced mobility under environmental conditions, since humic and fulvic acids carrying trace metals also would be strongly bound to e.g. clayish material. (author)

  4. Transient flows occurring during the accelerated crucible rotation technique

    International Nuclear Information System (INIS)

    Horowitz, Atara; Horowitz, Yigal

    1992-11-01

    The transient flows occurring after a change in the angular velocity of the cylindrical container are described. The dependence of the transient (known as spin-up or spin-down time) on experimental parameters as kinematic viscosity, cylinder dimensions and the cylinder's initial and final angular velocities are elucidates by a review of the literature. It is emphasized that with large Rossby numbers the spin-up time is longer and the amount of fluid mixing is greater than small and moderate Rossby numbers. It is also elucidated that most crystal growth crucibles cannot be considered as infinitely-long cylinders for the evaluation of the fluid dynamics (authors)

  5. A Rare Occurance with Epidermolysis Bullosa Disease: Dilated Cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Derya Cimen

    2014-02-01

    Full Text Available Epidermolysis bullosa is a congenital and herediter vesiculobullous disease. Dystrophic form of this disease is characterized by severe malnutrition, failure to thrive, adhesions at fingers, joint contractures related with the formation of scar tissues, carcinoma of the skin, anemia, hipoalbuminemia, wound enfections and sepsis. Rarely, mortal dilated cardiomyopathy may occur in patients. In this report we present a 13 year-old pediatric patient with dilated cardiomyopathy, clinically diagnosed with Epidermolysis bullosa as well as a review of recent related literature.

  6. Modelling of phase transformations occurring in low activation martensitic steels

    International Nuclear Information System (INIS)

    Brachet, J.-C.; Gavard, L.; Boussidan, C.; Lepoittevin, C.; Servant, C.

    1998-01-01

    The main objective of this paper is to summarize modelling of on-heating and on-cooling phase transformations occurring in low activation martensitic (LAM) steels. Calculations of thermodynamic equilibrium phase fractions and kinetic aspects of phase transformations have been performed by using different approaches from experimental data (CCT and TTT diagrams obtained by dilatometry). All the calculated data have been compared to an important and systematic set of experimental data obtained on different LAM steels of the 7.5-11% CrWVT a type. (orig.)

  7. Modelling of phase transformations occurring in low activation martensitic steels

    Science.gov (United States)

    Brachet, J.-C.; Gavard, L.; Boussidan, C.; Lepoittevin, C.; Denis, S.; Servant, C.

    1998-10-01

    The main objective of this paper is to summarize modelling of on-heating and on-cooling phase transformations occurring in Low Activation Martensitic (LAM) steels. Calculations of thermodynamic equilibrium phase fractions and kinetic aspects of phase transformations have been performed by using different approaches from experimental data (CCT and TTT diagrams obtained by dilatometry). All the calculated data have been compared to an important and systematic set of experimental data obtained on different LAM steels of the 7.5-11% CrWVT a type.

  8. Pseudo-Kaposi sarcoma (acroangiodermatitis): occurring after bullous erysipelas.

    Science.gov (United States)

    Kutlubay, Zekayi; Yardimci, Gürkan; Engin, Burhan; Demirkesen, Cuyan; Aydin, Övgü; Khatib, Rashid; Tuzun, Yalçın

    2015-05-18

    Pseudo-Kaposi sarcoma is a benign reactive vascular proliferative disorder, which can be seen at any age. It occurs when the chronic venous pressure changes result in vascular proliferation in the upper and mid dermis. This disease is divided into two subtypes: the most frequent subtype is the Mali type and seen in early ages. The Mali type is seen in chronic venous insufficiency and in those patients with arteriovenous shunts. The rare subtype is the Stewart-Bluefarb type. This disease must be distinguished from Kaposi sarcoma because of their clinical resemblance. Herein, we present a patient with pseudo-Kaposi sarcoma, which developed after bullous erysipelas.

  9. Estimating individual listeners’ auditory-filter bandwidth in simultaneous and non-simultaneous masking

    DEFF Research Database (Denmark)

    Buchholz, Jörg; Caminade, Sabine; Strelcyk, Olaf

    2010-01-01

    Frequency selectivity in the human auditory system is often measured using simultaneous masking of tones presented in notched noise. Based on such masking data, the equivalent rectangular bandwidth (ERB) of the auditory filters can be derived by applying the power spectrum model of masking....... Considering bandwidth estimates from previous studies based on forward masking, only average data across a number of subjects have been considered. The present study is concerned with bandwidth estimates in simultaneous and forward masking in individual normal-hearing subjects. In order to investigate...... the reliability of the individual estimates, a statistical resampling method is applied. It is demonstrated that a rather large set of experimental data is required to reliably estimate auditory filter bandwidth, particularly in the case of simultaneous masking. The poor overall reliability of the filter...

  10. Further Investigations on Simultaneous Ultrasonic Coal Flotation

    Directory of Open Access Journals (Sweden)

    Safak Gokhan Ozkan

    2017-09-01

    Full Text Available This study investigates the flotation performance of a representative hard coal slime sample (d80 particle size of minus 0.2 mm obtained from the Prosper-Haniel coal preparation plant located in Bottrop, Germany. Flotation was carried out with a newly designed flotation cell refurbished from an old ultrasonic cleaning bath (2.5 L volume equipped with a single frequency (35 kHz and two different power levels (80–160 W and a sub-aeration-type flotation machine operating at a stable impeller speed (1200 rpm and air rate (2.5 L/min. The reagent combination for conventional and simultaneous ultrasonic coal flotation tests was Ekofol-440 at variable dosages (40–300 g/t with controlling water temperature (20–25 °C at natural pH (6.5–7.0. The batch coal flotation results were analyzed by comparing the combustible recovery (% and separation efficiency (% values, taking mass yield and ash concentrations of the froths and tailings into account. It was found that simultaneous ultrasonic coal flotation increased yield and recovery values of the floated products with lower ash values than the conventional flotation despite using similar reagent dosages. Furthermore, particle size distribution of the ultrasonically treated and untreated coals was measured. Finely distributed coal particles seemed to be agglomerated during the ultrasonic treatment, while ash-forming slimes were removed by hydrodynamic cavitation.

  11. A desirability functions-based approach for simultaneous ...

    African Journals Online (AJOL)

    In order to improve product quality, all these quantitative and qualitative responses must be optimized simultaneously. ... Few researchers have proposed some alternative approaches for optimizing an ... quantitative and ordinal response variables simultaneously under Taguchi's framework of robust design approach.

  12. The use of simultaneous chemical precipitation in modified activated ...

    African Journals Online (AJOL)

    The use of simultaneous chemical precipitation in modified activated sludge systems exhibiting biological excess phosphate removal: Part 6: Modelling of simultaneous chemical-biological P removal - review of existing models.

  13. Naturally occurring Vpr inhibitors from medicinal plants of Myanmar.

    Science.gov (United States)

    Win, Nwet Nwet; Ngwe, Hla; Abe, Ikuro; Morita, Hiroyuki

    2017-10-01

    Human immunodeficiency virus type-1 (HIV-1) is a lentiviral family member that encodes the retroviral Gag, Pol, and Env proteins, along with six additional accessory proteins, Tat, Rev, Vpu, Vif, Nef, and Vpr. The currently approved anti-HIV drugs target the Pol and Env encoded proteins. However, these drugs are only effective in reducing viral replication. Furthermore, the drugs' toxicities and the emergence of drug-resistant strains have become serious worldwide problems. Resistance eventually arises to all of the approved anti-HIV drugs, including the newly approved drugs that target HIV integrase (IN). Drug resistance likely emerges because of spontaneous mutations that occur during viral replication. Therefore, new drugs that effectively block other viral components must be developed to reduce the rate of resistance and suppress viral replication with little or no long-term toxicity. The accessory proteins may expand treatment options. Viral protein R (Vpr) is one of the promising drug targets among the HIV accessory proteins. However, the search for inhibitors continues in anti-HIV drug discovery. In this review, we summarize the naturally occurring compounds discovered from two Myanmar medicinal plants as well as their structure-activity relationships. A total of 49 secondary metabolites were isolated from Kaempferia pulchra rhizomes and Picrasama javanica bark, and the types of compounds were identified as isopimarane diterpenoids and picrasane quassinoids, respectively. Among the isolates, 7 diterpenoids and 15 quassinoids were found to be Vpr inhibitors lacking detectable toxicity, and their potencies varied according to their respective functionalities.

  14. Pathology of Naturally Occurring Bacillary Hemoglobinuria in Cattle.

    Science.gov (United States)

    Navarro, M A; Dutra, F; Briano, C; Romero, A; Persiani, M; Freedman, J C; Morrell, E; Beingesser, J; Uzal, F A

    2017-05-01

    Clostridium haemolyticum causes bacillary hemoglobinuria (BH), an infectious and usually fatal disease that occurs mostly in cattle, which is clinically characterized by jaundice, hemoglobinuria, and anemia. The trematode Fasciola hepatica has been commonly reported as the main predisposing factor that triggers this condition. The authors evaluated 20 naturally occurring cases of bovine BH to characterize the pathology and pathogenesis of the disease. Grossly, the most consistent finding was a large, frequently single focus of necrosis surrounded by a red to purple halo, observed most frequently on the parietal surface of the right and left hepatic lobes. Other findings were jaundice, dark-brown discoloration of kidneys, and red urine in the urinary bladder. Microscopically, characteristic lesions were locally extensive, necrotizing hepatitis with thrombosis and numerous intralesional Gram-positive rod-shaped bacteria, and acute renal tubular necrosis. By immunohistochemistry, many hepatocytes outside the necrotic focus in the liver were positive for activated caspase 3, suggesting that those cells were undergoing apoptosis. Ultrastructural evaluation revealed hepatocyte necrosis, hemolysis, and clumps of vegetative and sporulating bacilli within the liver. Polymerase chain reaction for the C. haemolyticum beta toxin gene was positive in randomly selected liver samples. No gross or microscopic lesions indicative of fascioliasis were detected in the liver of any animal, suggesting that other yet undetermined predisposing factors were associated with these cases of BH.

  15. On the mechanical friction losses occurring in automotive differential gearboxes.

    Science.gov (United States)

    Antoni, Grégory

    2014-01-01

    In the automobile industry, the mechanical losses resulting from friction are largely responsible for various kinds of surface damage, such as the scuffing occurring in some mechanical assemblies. These scuffing processes seem to be due to a local loss of lubrication between certain mechanical elements of the same assembly, leading to a sharp increase in the friction, which can lead to a surface and volume damage in some of them, and even can cause, in the worst case, the whole destruction of the mechanical system if it has continued to operate. Predicting and checking the occurrence of this kind of undesirable phenomena, especially in some principal systems of the vehicle, represents nowadays, a crucial challenge in terms of automobile reliability and safety. This study focuses on the mechanical friction losses liable to occur in differential automobile gearboxes, which can lead in the long term to the scuffing of these mechanical systems. The friction losses involved were modeled, using a simple analytical approach, which is presented and discussed.

  16. Zygotic Genome Activation Occurs Shortly after Fertilization in Maize.

    Science.gov (United States)

    Chen, Junyi; Strieder, Nicholas; Krohn, Nadia G; Cyprys, Philipp; Sprunck, Stefanie; Engelmann, Julia C; Dresselhaus, Thomas

    2017-09-01

    The formation of a zygote via the fusion of an egg and sperm cell and its subsequent asymmetric division herald the start of the plant's life cycle. Zygotic genome activation (ZGA) is thought to occur gradually, with the initial steps of zygote and embryo development being primarily maternally controlled, and subsequent steps being governed by the zygotic genome. Here, using maize ( Zea mays ) as a model plant system, we determined the timing of zygote development and generated RNA-seq transcriptome profiles of gametes, zygotes, and apical and basal daughter cells. ZGA occurs shortly after fertilization and involves ∼10% of the genome being activated in a highly dynamic pattern. In particular, genes encoding transcriptional regulators of various families are activated shortly after fertilization. Further analyses suggested that chromatin assembly is strongly modified after fertilization, that the egg cell is primed to activate the translational machinery, and that hormones likely play a minor role in the initial steps of early embryo development in maize. Our findings provide important insights into gamete and zygote activity in plants, and our RNA-seq transcriptome profiles represent a comprehensive, unique RNA-seq data set that can be used by the research community. © 2017 American Society of Plant Biologists. All rights reserved.

  17. Daily intakes of naturally occurring radioisotopes in typical Korean foods.

    Science.gov (United States)

    Choi, Min-Seok; Lin, Xiu-Jing; Lee, Sun Ah; Kim, Wan; Kang, Hee-Dong; Doh, Sih-Hong; Kim, Do-Sung; Lee, Dong-Myung

    2008-08-01

    The concentrations of naturally occurring radioisotopes ((232)Th, (228)Th, (230)Th, (228)Ra, (226)Ra, and (40)K) in typical Korean foods were evaluated. The daily intakes of these radioisotopes were calculated by comparing concentrations in typical Korean foods and the daily consumption rates of these foods. Daily intakes were as follows: (232)Th, 0.00-0.23; (228)Th, 0.00-2.04; (230)Th, 0.00-0.26; (228)Ra, 0.02-2.73; (226)Ra, 0.01-4.37 mBq/day; and (40)K, 0.01-5.71 Bq/day. The total daily intake of the naturally occurring radioisotopes measured in this study from food was 39.46 Bq/day. The total annual internal dose resulting from ingestion of radioisotopes in food was 109.83 muSv/y, and the radioisotope with the highest daily intake was (40)K. These values were same level compiled in other countries.

  18. Economic losses occurring due to brucellosis in Indian livestock populations.

    Science.gov (United States)

    Singh, B B; Dhand, N K; Gill, J P S

    2015-05-01

    Brucellosis is a serious public health issue in India. Estimation of economic losses occurring due to brucellosis is required to help formulate prevention and control strategies, but has not been done in India. We estimated economic losses due to brucellosis by sourcing prevalence data from epidemiological surveys conducted in India. Data for livestock populations were obtained from official records. Probability distributions were used for many of the input parameters to account for uncertainty and variability. The analysis revealed that brucellosis in livestock is responsible for a median loss of US $ 3.4 billion (5th-95th percentile 2.8-4.2 billion). The disease in cattle and buffalo accounted for 95.6% of the total losses occurring due to brucellosis in livestock populations. The disease is responsible for a loss of US $ 6.8 per cattle, US$18.2 per buffalo, US $ 0.7 per sheep, US $ 0.5 per goat and US $ 0.6 per pig. These losses are additional to the economic and social consequences of the disease in humans. The results suggest that the disease causes significant economic losses in the country and should be controlled on a priority basis. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. Regulation of naturally occurring radioactive materials in Australia

    International Nuclear Information System (INIS)

    Jeffries, C.; Akber, R.; Johnston, A.; Cassels, B.

    2011-01-01

    In order to promote uniformity between jurisdictions, the Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) has developed the National Directory for Radiation Protection, which is a regulatory framework that all Australian governments have agreed to adopt. There is a large and diverse range of industries involved in mining or mineral processing, and the production of fossil fuels in Australia. Enhanced levels of naturally occurring radionuclides can be associated with mineral extraction and processing, other industries (e.g. metal recycling) and some products (e.g. plasterboard). ARPANSA, in conjunction with industry and State regulators, has undertaken a review and assessment of naturally occurring radioactive material (NORM) management in Australian industries. This review has resulted in guidance on the management of NORM that will be included in the National Directory for Radiation Protection. The first NORM safety guide provides the framework for NORM management and addresses specific NORM issues in oil and gas production, bauxite, aluminium and phosphate industries. Over time further guidance material for other NORM-related industries will be developed. This presentation will provide an overview of the regulatory approach to managing NORM industries in Australia. (authors)

  20. Regulation of naturally occurring radioactive materials in Australia.

    Science.gov (United States)

    Jeffries, Cameron; Akber, Riaz; Johnston, Andrew; Cassels, Brad

    2011-07-01

    In order to promote uniformity between jurisdictions, the Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) has developed the National Directory for Radiation Protection, which is a regulatory framework that all Australian governments have agreed to adopt. There is a large and diverse range of industries involved in mining or mineral processing, and the production of fossil fuels in Australia. Enhanced levels of naturally occurring radionuclides can be associated with mineral extraction and processing, other industries (e.g. metal recycling) and some products (e.g. plasterboard). ARPANSA, in conjunction with industry and State regulators, has undertaken a review and assessment of naturally occurring radioactive material (NORM) management in Australian industries. This review has resulted in guidance on the management of NORM that will be included in the National Directory for Radiation Protection. The first NORM safety guide provides the framework for NORM management and addresses specific NORM issues in oil and gas production, bauxite, aluminium and phosphate industries. Over time further guidance material for other NORM-related industries will be developed. This presentation will provide an overview of the regulatory approach to managing NORM industries in Australia.

  1. Peers and Co-Occurring Research-Supported Interventions.

    Science.gov (United States)

    Harrison, Jennifer; Cousins, Linwood; Spybrook, Jessaca; Curtis, Amy

    2017-01-01

    Adults with co-occurring mental illness and substance use disorders have poor outcomes in important quality of life areas, including hospitalization, incarceration, employment, and community housing. Integrated dual disorder treatment (IDDT) is a research-supported intervention for individuals with co-occurring disorders associated with improvements in outcome measures when implemented with high fidelity. Research-supported intervention IDDT was not designed with peer services, provided by people with lived experience with mental illness, but the practice has been altered to include peers. IDDT fidelity data were evaluated from 20 teams that also reported on peer services on their team in one state over a 7 year period, and paired with their fidelity data for the most recent review to analyze the relationship between peers and IDDT fidelity. Analysis of variance was utilized to determine a dose effect peers on fidelity. Of these IDDT teams, 85% of teams incorporated a peer and 40% of teams had a full-time peer. Having a full-time peer (M = 4.22, SD = .41) was associated with significantly higher fidelity compared to teams with a part-time (M = 3.68, SD = .56) or no peer (M = 3.21, SD = .18, F(2, 17) = 5.88, p = .01). Peers on IDDT teams are associated with higher fidelity, leading to important possibilities about the incorporation of those with lived experience into research-supported interventions. Implications for team composition, implementation measurement, policy, and funding are discussed.

  2. Daily intakes of naturally occurring radioisotopes in typical Korean foods

    International Nuclear Information System (INIS)

    Choi, Min-Seok; Lin Xiujing; Lee, Sun Ah; Kim, Wan; Kang, Hee-Dong; Doh, Sih-Hong; Kim, Do-Sung; Lee, Dong-Myung

    2008-01-01

    The concentrations of naturally occurring radioisotopes ( 232 Th, 228 Th, 230 Th, 228 Ra, 226 Ra, and 40 K) in typical Korean foods were evaluated. The daily intakes of these radioisotopes were calculated by comparing concentrations in typical Korean foods and the daily consumption rates of these foods. Daily intakes were as follows: 232 Th, 0.00-0.23; 228 Th, 0.00-2.04; 230 Th, 0.00-0.26; 228 Ra, 0.02-2.73; 226 Ra, 0.01-4.37 mBq/day; and 40 K, 0.01-5.71 Bq/day. The total daily intake of the naturally occurring radioisotopes measured in this study from food was 39.46 Bq/day. The total annual internal dose resulting from ingestion of radioisotopes in food was 109.83 μSv/y, and the radioisotope with the highest daily intake was 40 K. These values were same level compiled in other countries

  3. Genetic and molecular dissection of naturally occurring variations in rice

    Energy Technology Data Exchange (ETDEWEB)

    Yano, Masahiro [National Institute of Agrobiological Sciences, Tsukuba, Ibaraki (Japan)

    2002-02-01

    The progress for structural analysis of the rice genome has allowed us to embark on the sequencing of the whole rice genome. Resources - genetic markers, sequence data, and genomic clones - derived from many efforts will be used for the functional analysis of rice genes in the next decade. Although artificially induced variations, such as mutants, have been used mainly for genetic and physiological studies in rice and other plant species, the development of DNA markers has made possible access to naturally occurring allelic variations underlying complex traits. Such analysis is often referred to as quantitative traits locus (QTL) analysis. Many QTLs have been mapped for many complex traits in rice. During the analyses of several quantitative traits by the DNA marker-assisted strategy, two questions about QTL analysis have been raised: 1) Does a QTL represent a single Mendelian locus or a cluster of multiple loci? 2) Is it possible to precisely map a QTL and identify QTLs at the molecular level using map-based or other strategies? To answer these questions, a series of analyses on heading date, including the identification of putative QTLs, characterization and fine mapping of QTLs using nearly isogenic lines (NILs), and identification of genes at QTLs for heading date by the map-based strategy has been performed. In addition, several primary permanent mapping populations and secondary genetic resources, such as chromosomal segmental substitution lines, have been developed to facilitate the genetic analysis of naturally occurring allelic variation. (M. Suetake)

  4. Reference Material IAEA 434: Naturally Occurring Radionuclides in Phosphogypsum

    International Nuclear Information System (INIS)

    2010-01-01

    Phosphogypsum is generated as a by-product of the phosphoric acid based fertilizer industry. The discharge of phosphogypsum on earth surface deposits is a potential source of enhanced natural radiation and heavy metals, and the resulting environmental impact should be considered carefully to ensure safety and compliance with environmental regulations. In addition, phosphogypsum can be used to make several building materials and it is used in agriculture as a conditioner to maintain soil productivity in areas where soils are poor and erode easily. A reliable determination of naturally occurring radionuclides in phosphogypsum is necessary to comply with the radiation protection and environmental regulations. The IAEA-434 will assist laboratories in the IAEA Member States in validating their analytical methods for the determination of naturally occurring radionuclides in phosphogypsum and to control the quality of the produced analytical results. Reference values for the massic activities and associated standard uncertainties were established for: Pb-210, Ra-226, Th-230, U-234 and U-238. During sample production and certification, the requirements for reference material production and certification as stated in ISO guides 34 and 35 were taken into account. This report summarizes the preparation and certification process

  5. On the Mechanical Friction Losses Occurring in Automotive Differential Gearboxes

    Directory of Open Access Journals (Sweden)

    Grégory Antoni

    2014-01-01

    Full Text Available In the automobile industry, the mechanical losses resulting from friction are largely responsible for various kinds of surface damage, such as the scuffing occurring in some mechanical assemblies. These scuffing processes seem to be due to a local loss of lubrication between certain mechanical elements of the same assembly, leading to a sharp increase in the friction, which can lead to a surface and volume damage in some of them, and even can cause, in the worst case, the whole destruction of the mechanical system if it has continued to operate. Predicting and checking the occurrence of this kind of undesirable phenomena, especially in some principal systems of the vehicle, represents nowadays, a crucial challenge in terms of automobile reliability and safety. This study focuses on the mechanical friction losses liable to occur in differential automobile gearboxes, which can lead in the long term to the scuffing of these mechanical systems. The friction losses involved were modeled, using a simple analytical approach, which is presented and discussed.

  6. Thermodynamic characterization of tandem mismatches found in naturally occurring RNA

    Science.gov (United States)

    Christiansen, Martha E.; Znosko, Brent M.

    2009-01-01

    Although all sequence symmetric tandem mismatches and some sequence asymmetric tandem mismatches have been thermodynamically characterized and a model has been proposed to predict the stability of previously unmeasured sequence asymmetric tandem mismatches [Christiansen,M.E. and Znosko,B.M. (2008) Biochemistry, 47, 4329–4336], experimental thermodynamic data for frequently occurring tandem mismatches is lacking. Since experimental data is preferred over a predictive model, the thermodynamic parameters for 25 frequently occurring tandem mismatches were determined. These new experimental values, on average, are 1.0 kcal/mol different from the values predicted for these mismatches using the previous model. The data for the sequence asymmetric tandem mismatches reported here were then combined with the data for 72 sequence asymmetric tandem mismatches that were published previously, and the parameters used to predict the thermodynamics of previously unmeasured sequence asymmetric tandem mismatches were updated. The average absolute difference between the measured values and the values predicted using these updated parameters is 0.5 kcal/mol. This updated model improves the prediction for tandem mismatches that were predicted rather poorly by the previous model. This new experimental data and updated predictive model allow for more accurate calculations of the free energy of RNA duplexes containing tandem mismatches, and, furthermore, should allow for improved prediction of secondary structure from sequence. PMID:19509311

  7. Relations between the simultaneous and sequential transfer of two nucleons

    International Nuclear Information System (INIS)

    Satchler, G.R.

    1982-01-01

    The transfer of two nucleons between projectile and target in a direct or peripheral reaction such as (p,t) or ( 16 O, 14 C) may occur in one-step or two-steps. These we refer to as simultaneous and sequential transfers, respectively. In the former, the interaction acts once and both nucleons are transferred. In the latter, the interaction acts once to transfer one nucleon, the system then propagates in one or more intermediate states and is followed by a second action of the interaction to transfer the second nucleon. This process may be symbolized for the examples as (p,d; d,t) and ( 16 O, 15 N; 15 N, 14 C), implying the intermediate formation of a deuteron or the nucleus 15 N. In terms of a perturbation theory expansion, such as the distorted-wave Born series, simultaneous transfer is possible in first order while sequential transfer requires second order. The nuclear forces are predominantly two-body in character; hence, in first-order only one of the two nucleons experiences an interaction. The possibility of finding that the other nucleon has also transferred arises only because its state within the projectile is not orthogonal to the state in the target into which it transfers. In the two-step process each nucleon is transferred under the direct influence of an interaction with the target. The one-step and two-step amplitudes are frequently comparable in magnitude for light-ion reactions while the two-step may dominate in reactions with heavy ions. Our purpose here is to gain some insight into the relationship between the two amplitudes by using a simple approximate form of the theory. For simplicity, we shall discuss a light-ion reaction and, to be specific, we choose the (t,p) reaction (or the inverse (p,t) reaction)

  8. Simultaneous maximum a posteriori longitudinal PET image reconstruction

    Science.gov (United States)

    Ellis, Sam; Reader, Andrew J.

    2017-09-01

    Positron emission tomography (PET) is frequently used to monitor functional changes that occur over extended time scales, for example in longitudinal oncology PET protocols that include routine clinical follow-up scans to assess the efficacy of a course of treatment. In these contexts PET datasets are currently reconstructed into images using single-dataset reconstruction methods. Inspired by recently proposed joint PET-MR reconstruction methods, we propose to reconstruct longitudinal datasets simultaneously by using a joint penalty term in order to exploit the high degree of similarity between longitudinal images. We achieved this by penalising voxel-wise differences between pairs of longitudinal PET images in a one-step-late maximum a posteriori (MAP) fashion, resulting in the MAP simultaneous longitudinal reconstruction (SLR) method. The proposed method reduced reconstruction errors and visually improved images relative to standard maximum likelihood expectation-maximisation (ML-EM) in simulated 2D longitudinal brain tumour scans. In reconstructions of split real 3D data with inserted simulated tumours, noise across images reconstructed with MAP-SLR was reduced to levels equivalent to doubling the number of detected counts when using ML-EM. Furthermore, quantification of tumour activities was largely preserved over a variety of longitudinal tumour changes, including changes in size and activity, with larger changes inducing larger biases relative to standard ML-EM reconstructions. Similar improvements were observed for a range of counts levels, demonstrating the robustness of the method when used with a single penalty strength. The results suggest that longitudinal regularisation is a simple but effective method of improving reconstructed PET images without using resolution degrading priors.

  9. Exploring naturally occurring ivy nanoparticles as an alternative biomaterial.

    Science.gov (United States)

    Huang, Yujian; Wang, Yi-Jun; Wang, Yongzhong; Yi, Sijia; Fan, Zhen; Sun, Leming; Lin, Derrick; Anreddy, Nagaraju; Zhu, Hua; Schmidt, Michael; Chen, Zhe-Sheng; Zhang, Mingjun

    2015-10-01

    Arabinoglactan protein (AGP)-rich nanoparticles obtained from the sticky exudates of Hedera helix (English ivy), have shown promising potential to be used in nanomedicine owing to their excellent aqueous solubility, low intrinsic viscosity, biocompatibility, and biodegradability. In this study, the feasibilities of utilizing ivy nanoparticles (INPs) as nano-carriers for delivering chemotherapeutic drugs in cancer therapy and as nano-fillers to develop novel scaffolds for tissue engineering in regenerative medicine are evaluated. Via electrostatic and hydrophobic interactions, pH-responsive nanoconjugates are formed between the INPs and the doxorubicin (DOX) with an entrapment ratio of 77.9±3.9%. While the INPs show minimal cytotoxicity, the formed INP-DOX conjugates exhibit substantially stronger cytotoxic activity than free DOX against multiple cancer cell lines, suggesting a synergistic effect is established upon conjugation. The anti-cancer effects of the INP-DOX conjugates are further evaluated via in vivo xenograft assays by subcutaneously implanting DOX resistant cell line, SW620/Ad-300, into nude mice. The tumor volumes in mice treated with the INP-DOX conjugates are significantly less than those of the mice treated with free DOX. In addition, the INPs are further exploited as nano-fillers to develop fibrous scaffolds with collagen, via mimicking the porous matrix where the INPs are embedded under natural condition. Enhanced adhesion of smooth muscle cells (SMCs) and accelerated proliferation of mouse aortic SMCs are observed in this newly constructed scaffold. Overall, the results obtained from the present study suggest great potential of the INPs to be used as biocompatible nanomaterials in nanomedicine. The AGP-rich INP renders a glycoprotein architecture that is amenable for modification according to the functional designs, capable of being developed as versatile nanomaterials for extensive biomedical applications. Naturally occurring organic

  10. Lichen striatus occurring after a tetanus vaccine: A case report

    Directory of Open Access Journals (Sweden)

    Ayşegül Yalçınkaya İyidal

    2017-06-01

    Full Text Available Lichen striatus (LS is an uncommon, acquired, self-limiting, linear inflammatory dermatosis. The eruption typically presents as pink or tan papules along Blaschko’s lines. It usually occurs in children, rarely affects adults. The rashes usually suddenly emerge in a single extremity and may regress within a few months or years. The incidence is slightly higher among women. The etiology of LS is not exactly known, however, it is thought to be a T cell-mediated autoimmune reaction. Trauma, infection, pregnancy, drugs, vaccination, and atopy have been reported as triggering factors. In the literature, four cases of LS developing after vaccination (3 children and 1 adult have been reported. It was the only reported adult case of LS developing after hepatitis B virus vaccination. Herein, we present a 36-year-old woman with LS which was thought to be triggered by a tetanus vaccine.

  11. Immunoregulation by naturally occurring and disease-associated autoantibodies

    DEFF Research Database (Denmark)

    Nielsen, Claus H; Bendtzen, Klaus

    2012-01-01

    The role of naturally occurring autoantibodies (NAbs) in homeostasis and in disease manifestations is poorly understood. In the present chapter, we review how NAbs may interfere with the cytokine network and how NAbs, through formation of complement-activating immune complexes with soluble self......-receptors on antigen-presenting cells and thereby regulate T-cell activity. Knowledge of the influence of NAbs against cytokines on immune homeostasis is likely to have wide-ranging implications both in understanding pathogenesis and in treatment of many immunoinflammatory disorders, including a number of autoimmune......-stimulating factor, interferon (IFN)-α, IFN-β, IFN-γ, macrophage chemotactic protein-1 and IL-21. NAbs against a variety of other self-antigens have also been reported, and using thyroglobulin as an example we discuss how NAbs are capable of promoting uptake of immune complexes via complement receptors and Fc...

  12. Spreading depolarizations occur in human ischemic stroke with high incidence

    DEFF Research Database (Denmark)

    Dohmen, C.; Sakowitz, O.W.; Fabricius, M.

    2008-01-01

    Objective: Cortical spreading depression (CSD) and periinfarct depolarization (PID) have been shown in various experimental models of stroke to cause secondary neuronal damage and infarct expansion. For decades it has been questioned whether CSD or PID occur in human ischemic stroke. Here, we...... for decompressive hernicraniectomy, an electrode strip was placed on the periinfarct region, from which four FCoG channels were acquired. Results: A total of 1,638 hours was recorded; mean monitoring time per patient was 109.2 hours. A total of 127 CSD and 42 PID events were observed. In CSD, a stereotyped slow...... frequency in this study of patients with malignant middle cerebral artery infarction. This suggests that the large volume of experimental studies of occlusive stroke that implicate spreading depolarizations in its pathophysiology can be translated, with appropriate caution, to patients and their treatment...

  13. Naturally occuring radioactivity in residues of drinking water treatment

    International Nuclear Information System (INIS)

    Vornehm, C.; Mallick, R.

    2009-01-01

    In the course of a research project about 500 residues of drinking water treatment from approx. 400 water supply companies in Bavaria were investigated on naturally occurring radioactivity. For each residue the effective dose for workers was evaluated for each residue. The results show that increased activities, particularly of Radium-226, can be found in the material. The dose due to the exposure to the residues, which mostly result from the backwashing of filters, is below the reference value of 1 mSv/a, which can be used according to paragraph 97 of the German radiation protection standard. During the project the quantity of residues in Bavaria and the ways of their disposal were evaluated. In addition the relation between the amount of natural radioisotopes in the residues and the geological and hydrochemical conditions of the water catchment area was pointed out. (orig.)

  14. General properties of grapevine viruses occurring in Hungary

    Directory of Open Access Journals (Sweden)

    Eszter Cseh

    2012-03-01

    Full Text Available The past fifty years important advances have been made in the field of grapevine virus research, including characterization of pathogens and control measurements. Still the occurrence of Grapevine fanleaf virus (GFLV, Arabis mosaic virus (ArMV, Tomato black ring virus (TBRV, Grapevine chrome mosaic virus (GCMV, Alfalfa mosaic virus (AMV, Grapevine Bulgarian latent virus (GBLV, Grapevine fleck virus (GFkV, Grapevine leafroll- associated viruses (GLRaV1-4, Grapevine virus A (GVA, Grapevine virus B (GVB and Grapevine rupestris stem pitting- associated virus (GRSPaV have been reported in Hungary and characterized by conventional methods as woody indexing, herbaceous indexing and serological methods. Among grapevine viruses the Grapevine line pattern virus (GLPV seems to be uncial; because it was reported only in Hungary. Causal agents of several grapevine diseases, like enation, vein necrosis and vein mosaic remained undiscovered. These virus-like diseases occurred only sporadically, without economic importance.

  15. A study on hazard types occurring in hydrogen facilities

    International Nuclear Information System (INIS)

    Cho, Nam Chul; Jae, Moo Sung; Eon, Yang Joon

    2004-01-01

    Hydrogen has ideal characteristics as an energy carrier. Hydrogen can be used as a clean fuel in a variety of energy end-use sectors including the conversion to electricity. After combustion, it produces only water. Therefore, the concept of hydrogen energy system has attracted much interest worldwide. But hydrogen has a defect that the explosion risk is high to an inflammable gas of a colorless, tasteless and odorless. Therefore, to use the hydrogen to the source of energy, hydrogen accident sequences and causes analysis must be needed. For this, hazard types occurring in hydrogen facilities have been considered through the case of domestic and foreign hydrogen accident in this study and hazard types to be considered are ignition, leaks, hydrogen dispersion, fire an explosion, storage vessel failure, vent and exhaust system, purging, condensation of air, hydrogen embrittlement, physiological hazard, and collisions during transportation

  16. Lupus vulgaris occurring in a locus minoris resistentiae.

    Science.gov (United States)

    Long, Richard; Beatch, Anita; Lee, Mao-Cheng; Cheung-Lee, Melody; Wasel, Norman

    2009-01-01

    The pathogenesis of lupus vulgaris, a form of cutaneous tuberculosis, is not always clear, especially in patients who do not have coexistent extracutaneous tuberculosis and in patients with single lesions. To report a case of lupus vulgaris in a locus minoris resistentiae (a site of reduced resistance) and to use a unique set of clinical circumstances and laboratory tests to reconstruct the pathogenesis of the lesion and the response to treatment. Lupus vulgaris can occur in a locus minoris resistentiae; local trauma and possibly other factors, such as increased temperature, topical corticosteroids, and the virulence of the infecting strain, may facilitate the growth of Mycobacterium tuberculosis present at a locus minoris resistentiae as a result of a silent bacillemia.

  17. Modelling of damping forces occuring in simple MEMS systems

    Directory of Open Access Journals (Sweden)

    Kamil Urbanowicz

    2015-12-01

    Full Text Available A certain damping force occurs in the micro-mechanical systems referred as MEMS. At the design stage of such systems, these forces must be accurately estimated. As shown in this work, in all systems operating at low frequencies, most important force is the one associated with the flotation of air film from the volume between two parallel operating movable MEMS plates. This force can be accurately estimated by analytical methods known from the literature. The paper presents analytical solutions that are frequently used in practice for simple plates. Also some simple simulations, using all described analytical solutions compared with the results of specialized program called Comsol Multyphysics, are shown. Presented research demonstrate the effectiveness of numerical software.[b]Keywords[/b]: MEMS, damping forces, Reynolds equation, modelling, simulation

  18. Modification of radiation damage by naturally occurring substances

    International Nuclear Information System (INIS)

    Prasad, K.N.

    1984-01-01

    The major objectives of studying the modification of radiation sensitivity have been (1) to identify a compound that will produce a differential protection or sensitization of the effect of irradiation on normal and tumor tissue, and (2) to understand more about the mechanisms of radiation damage. In spite of massive research on this particular problem since World War II, the first objective remains elusive. During this period, numerous radioprotective and radiosensitizing agents have been identified. These agents have served as important biologic tools for increasing our understanding of radiation injuries. Most of these substances are synthetic compounds and are very toxic to humans. In addition, very few of the compounds provide differential modifications of the effect of radiation on tumor and normal cells. This chapter presents objectives for identifying naturally occurring substances that modify the effect of x-radiation on mammalian cells and discusses the role of physiologic substances in modifying radiation injuries on mammalian normal and tumor cells

  19. Late Acute Rejection Occuring in Liver Allograft Recipients

    Directory of Open Access Journals (Sweden)

    Eric M Yoshida

    1996-01-01

    Full Text Available To study the effect of immunosuppressive reduction on the incidence and consequence of late acute rejection (LAR in liver allograft recipients, mean daily prednisone dose, mean cyclosporine A (CsA trough and nadir levels were retrospectively reviewed for the nearest 12-week period preceding six episodes of LAR in five liver allograft recipients (group 1. Results were compared with those from a cohort of 12 liver allograft recipients who did not develop LAR (group 2. LAR was defined as acute rejection occurring more than 365 days post-transplantation. Median follow-up for both groups was similar (504 days, range 367 to 1050, versus 511 days, range 365 to 666, not significant. Mean trough CsA levels were lower in patients with LAR compared with those without (224±66 ng/mL versus 233±49 ng/mL but the difference was not statistically significant. In contrast, mean daily prednisone dose (2.5±1.6 mg/ day versus 6.5±2.9 mg/day, P=0.007 and CsA nadir values (129±60 ng/mL versus 186±40 ng/mL, P=0.03 were significantly lower in patients who developed LAR compared with those who did not. Five of six episodes (83% of LAR occurred in patients receiving less than 5 mg/day of prednisone, versus a single LAR episode in only one of 12 patients (8% receiving prednisone 5 mg/day or more (P=0.004. In all but one instance, LAR responded to pulse methylprednisolone without discernible affect on long term graft function. The authors conclude that liver allograft recipients remain vulnerable to acute rejection beyond the first post-transplant year; and reduction of immunosuppressive therapy, particularly prednisone, below a critical, albeit low dose, threshold increases the risk of LAR.

  20. Forecasting seizures in dogs with naturally occurring epilepsy.

    Directory of Open Access Journals (Sweden)

    J Jeffry Howbert

    Full Text Available Seizure forecasting has the potential to create new therapeutic strategies for epilepsy, such as providing patient warnings and delivering preemptive therapy. Progress on seizure forecasting, however, has been hindered by lack of sufficient data to rigorously evaluate the hypothesis that seizures are preceded by physiological changes, and are not simply random events. We investigated seizure forecasting in three dogs with naturally occurring focal epilepsy implanted with a device recording continuous intracranial EEG (iEEG. The iEEG spectral power in six frequency bands: delta (0.1-4 Hz, theta (4-8 Hz, alpha (8-12 Hz, beta (12-30 Hz, low-gamma (30-70 Hz, and high-gamma (70-180 Hz, were used as features. Logistic regression classifiers were trained to discriminate labeled pre-ictal and inter-ictal data segments using combinations of the band spectral power features. Performance was assessed on separate test data sets via 10-fold cross-validation. A total of 125 spontaneous seizures were detected in continuous iEEG recordings spanning 6.5 to 15 months from 3 dogs. When considering all seizures, the seizure forecasting algorithm performed significantly better than a Poisson-model chance predictor constrained to have the same time in warning for all 3 dogs over a range of total warning times. Seizure clusters were observed in all 3 dogs, and when the effect of seizure clusters was decreased by considering the subset of seizures separated by at least 4 hours, the forecasting performance remained better than chance for a subset of algorithm parameters. These results demonstrate that seizures in canine epilepsy are not randomly occurring events, and highlight the feasibility of long-term seizure forecasting using iEEG monitoring.

  1. Naturally occurring radionuclides in agricultural products: An overview

    International Nuclear Information System (INIS)

    Hanlon, E.A.

    1994-01-01

    Low levels of naturally occurring radionuclides exist in phosphatic clays, a by-product of phosphatic mining and beneficiation processes. Concerns about these radionuclides entering the human food chain were an immediate research priority before the phosphate clays could be reclaimed for intensive agricultural purposes. Efforts included the assembly of a large body of data from both sons and plants, part of which were produced by the Polk County (Florida) Mined Lands Agricultural Research/Demonstration Project MLAR/DP. Additional detailed studies involving dairy and beef cattle (Bos taurus) were conducted by researchers working with the MLAR/DP. A national symposium was conducted in which data concerning the MLAR/DP work and other research projects also dealing with naturally occurring radionuclides in agriculture could be discussed. The symposium included invited review papers dealing with the identification of radionuclide geological origins, the geochemistry and movement of radionuclides within the environment, mechanisms of plant uptake, entry points into the food chain, and evaluation of dose and risk assessment to the consumer of low levels of radionuclides. The risk to human health of an individual obtaining 0.1 of his or her dietary intake from crops produced on phosphatic clays increased by 1 in 5 x 10 6 /yr above a control individual consuming no food grown on phosphatic clays. Leaf tissues were found to be generally higher than fruit, grain, or root tissues. The natural range in radionuclide content among various food types was greater than the difference in radionuclides content between the same food produced on phosphatic clays vs. natural soils. 19 refs

  2. Simultaneous G-Quadruplex DNA Logic.

    Science.gov (United States)

    Bader, Antoine; Cockroft, Scott L

    2018-04-03

    A fundamental principle of digital computer operation is Boolean logic, where inputs and outputs are described by binary integer voltages. Similarly, inputs and outputs may be processed on the molecular level as exemplified by synthetic circuits that exploit the programmability of DNA base-pairing. Unlike modern computers, which execute large numbers of logic gates in parallel, most implementations of molecular logic have been limited to single computing tasks, or sensing applications. This work reports three G-quadruplex-based logic gates that operate simultaneously in a single reaction vessel. The gates respond to unique Boolean DNA inputs by undergoing topological conversion from duplex to G-quadruplex states that were resolved using a thioflavin T dye and gel electrophoresis. The modular, addressable, and label-free approach could be incorporated into DNA-based sensors, or used for resolving and debugging parallel processes in DNA computing applications. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Quantitative simultaneous PET-MR imaging

    Science.gov (United States)

    Ouyang, Jinsong; Petibon, Yoann; Huang, Chuan; Reese, Timothy G.; Kolnick, Aleksandra L.; El Fakhri, Georges

    2014-06-01

    Whole-body PET is currently limited by the degradation due to patient motion. Respiratory motion degrades imaging studies of the abdomen. Similarly, both respiratory and cardiac motions significantly hamper the assessment of myocardial ischemia and/or metabolism in perfusion and viability cardiac PET studies. Based on simultaneous PET-MR, we have developed robust and accurate MRI methods allowing the tracking and measurement of both respiratory and cardiac motions during abdominal or cardiac studies. Our list-mode iterative PET reconstruction framework incorporates the measured motion fields into PET emission system matrix as well as the time-dependent PET attenuation map and the position dependent point spread function. Our method significantly enhances the PET image quality as compared to conventional methods.

  4. Simultaneous bilateral patellar tendon rupture without

    Directory of Open Access Journals (Sweden)

    LU Hua-ding

    2012-04-01

    Full Text Available 【Abstract】There is a dearth of case reports de-scribing simultaneous bilateral patellar tendon ruptures in the medical literature. These ruptures are often associated with systemic disorders such as lupus erythematosus or chronic steroid use. The author describes a case of a 24-year-old man who sustained traumatic bilateral patellar ten-don ruptures without any history of systemic disease or steroidal medication. We repaired and reattached the rup-tured tendons to the patella and augmented our procedure with allogeneic tendon followed by wire loop reinforcement. One year after operation, the patient regained a satisfactory range of motion of both knees with good quadriceps strength and no extensor lag. The recurrent microtrauma from a history of intense sports activity and a high body mass index may have played an important role in this trauma event. Key words: Patella; Patellar ligament; Rupture; Ten-don injuries; Knee

  5. Spectral-decomposition techniques for the identification of radon anomalies temporally associated with earthquakes occurring in the UK in 2002 and 2008.

    Science.gov (United States)

    Crockett, R. G. M.; Gillmore, G. K.

    2009-04-01

    During the second half of 2002, the University of Northampton Radon Research Group operated two continuous hourly-sampling radon detectors 2.25 km apart in Northampton, in the (English) East Midlands. This period included the Dudley earthquake (22/09/2002) which was widely noticed by members of the public in the Northampton area. Also, at various periods during 2008 the Group has operated another pair of continuous hourly-sampling radon detectors similar distances apart in Northampton. One such period included the Market Rasen earthquake (27/02/2008) which was also widely noticed by members of the public in the Northampton area. During each period of monitoring, two time-series of radon readings were obtained, one from each detector. These have been analysed for evidence of simultaneous similar anomalies: the premise being that big disturbances occurring at big distances (in relation to the detector separation) should produce simultaneous similar anomalies but that simultaneous anomalies occurring by chance will be dissimilar. As previously reported, cross-correlating the two 2002 time-series over periods of 1-30 days duration, rolled forwards through the time-series at one-hour intervals produced two periods of significant correlation, i.e. two periods of simultaneous similar behaviour in the radon concentrations. One of these periods corresponded in time to the Dudley earthquake, the other corresponded in time to a smaller earthquake which occurred in the English Channel (26/08/2002). We here report subsequent investigation of the 2002 time-series and the 2008 time-series using spectral-decomposition techniques. These techniques have revealed additional simultaneous similar behaviour in the two radon concentrations, not revealed by the rolling correlation on the raw data. These correspond in time to the Manchester earthquake swarm of October 2002 and the Market Rasen earthquake of February 2008. The spectral-decomposition techniques effectively ‘de-noise' the

  6. Discriminative predation: Simultaneous and sequential encounter experiments

    Directory of Open Access Journals (Sweden)

    C. D. BEATTY, D.W.FRANKS

    2012-08-01

    Full Text Available There are many situations in which the ability of animals to distinguish between two similar looking objects can have significant selective consequences. For example, the objects that require discrimination may be edible versus defended prey, predators versus non-predators, or mates of varying quality. Working from the premise that there are situations in which discrimination may be more or less successful, we hypothesized that individuals find it more difficult to distinguish between stimuli when they encounter them sequentially rather than simultaneously. Our study has wide biological and psychological implications from the perspective of signal perception, signal evolution, and discrimination, and could apply to any system where individuals are making relative judgments or choices between two or more stimuli or signals. While this is a general principle that might seem intuitive, it has not been experimentally tested in this context, and is often not considered in the design of models or experiments, or in the interpretation of a wide range of studies. Our study is different from previous studies in psychology in that a the level of similarity of stimuli are gradually varied to obtain selection gradients, and b we discuss the implications of our study for specific areas in ecology, such as the level of perfection of mimicry in predator-prey systems. Our experiments provide evidence that it is indeed more difficult to distinguish between stimuli – and to learn to distinguish between stimuli – when they are encountered sequentially rather than simultaneously, even if the intervening time interval is short [Current Zoology 58 (4: 649–657, 2012].

  7. The Brain's Reward Response Occurs Even Without Actual Reward!

    Science.gov (United States)

    Fielding, A; Fu, Y; Franz, E A

    2017-10-12

    What if the brain's response to reward occurs even when there is no reward? Wouldn't that be a further concern for people prone to problem gambling and other forms of addiction, like those related to eating? Electroencephalography was employed to investigate this possibility using probabilistic feedback manipulations and measures of known event-related potentials (ERPs) related to reward processing. We tested the hypothesis-that reward-based ERPs would occur even in the absence of a tangible reward and when manipulations on expectation are implicit. The well-known P300 response potential was a key focus, and was assessed in non-gambling volunteer undergraduates on a task involving experimentally-manipulated probabilities of positive or negative feedback comprising three trial types-80, 50, or 20% positive feedback. A feedback stimulus (F1) followed a guess response between two possible outcomes (implicit win/loss), and then a second feedback stimulus (F2) was presented to confirm an alleged 'win' or 'loss' (explicit win/loss). Results revealed that amplitude of the P300 in F1-locked data (implicit manipulation) was larger (more positive) on average for feedback outcomes that were manipulated to be less likely than expected. The effect is pronounced after increased time on task (later trials), even though the majority of participants were not explicitly aware of our probability manipulations. For the explicit effects in F2-locked data, no meaningful or significant effects were observed. These findings point to the existence of proposed success-response mechanisms that operate not only explicitly but also with implicit manipulations that do not involve any direct indication of a win or loss, and are not associated with tangible rewards. Thus, there seems to be a non-explicit form of perception (we call 'implicit') associated with an internal experience of wins/losses (in the absence of actual rewards or losses) that can be measured in associated brain processes. The

  8. Intravenous Topiramate: Pharmacokinetics in Dogs with Naturally-Occurring Epilepsy

    Directory of Open Access Journals (Sweden)

    Irene Vuu

    2016-12-01

    Full Text Available Barriers to developing treatments for human status epilepticus (SE include the inadequacy of experimental animal models. In contrast, naturally-occurring canine epilepsy is similar to the human condition and can serve as a platform to translate research from rodents to humans. The objectives of this study were to characterize the pharmacokinetics (PK of an intravenous (IV dose of topiramate (TPM in dogs with epilepsy, and evaluate its effect on intracranial electroencephalographic (iEEG features. Five dogs with naturally occurring epilepsy were used for this study. Three were getting at least one antiseizure drug as maintenance therapy including phenobarbital (PB. Four (ID 1-4 were used for the 10 mg/kg IV TPM + PO TPM study, and three (ID 3-5 were used for the 20 mg/kg IV TPM study. IV TPM was infused over 5 minutes at both doses. The animals were observed for vomiting, diarrhea, ataxia, and lethargy. Blood samples were collected at scheduled pre- and post-dose times. Plasma concentrations were measured using a validated HPLC-MS method. Non-compartmental and population compartmental modeling were performed (Phoenix WinNonLin and NLME using plasma concentrations from all dogs in the study. Intracranial EEG (iEEG was acquired in one dog. The difference between averaged iEEG energy levels at 15 minutes pre- and post-dose was assessed using a Kruskal-Wallis test. No adverse events were noted. Topiramate concentration-time profiles were best fit by a two-compartment model. PB co-administration was associated with a 5.6 fold greater clearance and a ~4 fold shorter elimination half-life. iEEG data showed that TPM produced a significant energy increase at frequencies >4 Hz across all 16 electrodes within 15 minutes of dosing. Simulations suggested that dogs on an enzyme inducer would require 25 mg/kg, while dogs on non-inducing drugs would need 20 mg/kg to attain the target concentration (20-30 µg/mL at 30-minutes post-dose.This study shows that IV

  9. Intravenous Topiramate: Pharmacokinetics in Dogs with Naturally Occurring Epilepsy.

    Science.gov (United States)

    Vuu, Irene; Coles, Lisa D; Maglalang, Patricia; Leppik, Ilo E; Worrell, Greg; Crepeau, Daniel; Mishra, Usha; Cloyd, James C; Patterson, Edward E

    2016-01-01

    Barriers to developing treatments for human status epilepticus include the inadequacy of experimental animal models. In contrast, naturally occurring canine epilepsy is similar to the human condition and can serve as a platform to translate research from rodents to humans. The objectives of this study were to characterize the pharmacokinetics of an intravenous (IV) dose of topiramate (TPM) in dogs with epilepsy and evaluate its effect on intracranial electroencephalographic (iEEG) features. Five dogs with naturally occurring epilepsy were used for this study. Three were getting at least one antiseizure drug as maintenance therapy including phenobarbital (PB). Four (ID 1-4) were used for the 10 mg/kg IV TPM + PO TPM study, and three (ID 3-5) were used for the 20 mg/kg IV TPM study. IV TPM was infused over 5 min at both doses. The animals were observed for vomiting, diarrhea, ataxia, and lethargy. Blood samples were collected at scheduled pre- and post-dose times. Plasma concentrations were measured using a validated high-performance liquid chromatography-mass spectrometry method. Non-compartmental and population compartmental modeling were performed (Phoenix WinNonLin and NLME) using plasma concentrations from all dogs in the study. iEEG was acquired in one dog. The difference between averaged iEEG energy levels at 15 min pre- and post-dose was assessed using a Kruskal-Wallis test. No adverse events were noted. TPM concentration-time profiles were best fit by a two compartment model. PB co-administration was associated with a 5.6-fold greater clearance and a ~4-fold shorter elimination half-life. iEEG data showed that TPM produced a significant energy increase at frequencies >4 Hz across all 16 electrodes within 15 min of dosing. Simulations suggested that dogs on an enzyme inducer would require 25 mg/kg, while dogs on non-inducing drugs would need 20 mg/kg to attain the target concentration (20-30 μg/mL) at 30 min post-dose. This study

  10. OCCURANCE OF HISTAMINE IN FISH PRODUCTS ON MARKET

    Directory of Open Access Journals (Sweden)

    R. Mancusi

    2012-08-01

    Full Text Available Histamine fish poisoning is quite common and occur in consequence of microbial decarboxylase whose activity begin early in the post-mortem but are triggered in consequence of abuse in the shelf life of fish products. In this study forty-eight samples of tuna, mackerel, anchovies, sardines, fresh or processed were sampled from fish shops and supermarkets in the City of Bologna in the period from January to July 2010. Concentration of histamine was assessed using ELISA quantitative test and presence of psicrotrophic histamine forming bacteria was searched using a modified Niven agar medium which allow detection of suspect colonies that were confirmed by PCR for detecting the presence of the histidine decarboxylase genes in their DNA. The positive colonies were then identified on the basis of their morphology, Gram reaction and biochemical characteristics with API20E. The differential capability of the Niven agar was found to be low and approximately one fifth of the suspect colonies were confirmed by the PCR test, which however included both strong and weak histamine producing strains. The presence of Morganella morganii was associated with concentration of histamine 460 mg∙kg-1 above the allowed limit in a sample of tuna sampled from a fish shop. The same bacterium was found in samples of Atlantic horse mackerel (Trachurus trachurus. High histamine concentration (between 258 and > 300 mg∙kg-1 were observed in salted European pilchard and European anchovy (228 mg∙kg-1 sold loose in supermarkets. Because temperature abuse could occur when Tuna (fresh/defrozen are hold on chopping board to sell fresh cuts and during shelf life of salted pilchard and pickled anchovies held in opened cans in chilled display cabinets for extended period, which might results in very high histamine concentration, controls on time and temperature at the retail, in addition to those done during the harvest and processing are needed. The studies aiming at

  11. Simultaneous acute appendicitis with right testicular torsion

    Directory of Open Access Journals (Sweden)

    Tanveer Akhtar

    2012-01-01

    Full Text Available We present a child with both acute appendicitis and torsion of the right testis presenting at the same time. Testicular torsion possibly occurring due to vomiting in acute appendicitis so far has not been reported in the literature.

  12. Sexual recombination in Colletotrichum lindemuthianum occurs on a fine scale.

    Science.gov (United States)

    Souza, E A; Camargo, O A; Pinto, J M A

    2010-09-08

    Glomerella cingulata f. sp phaseoli is the sexual phase of the fungus Colletotrichum lindemuthianum, the causal agent of common bean anthracnose. This fungus is of great concern, because it causes large economic losses in common bean crops. RAPD markers of five populations of G. cingulata f. sp phaseoli from two Brazilian states were analyzed to determine if this population possesses the sexual reproductive potential to generate the genetic variation that is observed in this phytopathogen. We identified 128 polymorphic bands, amplified by 28 random primers. The estimates of genetic similarity in this analysis ranged from 0.43 to 1.00, and the dendrogram generated from analysis of all genotypes displayed five principal groups, coinciding with the five populations. Genetic differentiation was observed between the populations (GST=0.6455); 69% of the overall observed genetic variation was between individual populations and 31% of the variance was within the sub-populations. We identified significant levels of linkage disequilibrium in all populations. However, the values of the disequilibrium ranged from low to moderate, indicating that this pathogen maintains a genetic structure consistent with sexual reproduction. The mean contribution of sexual reproduction was determined by comparison of the amplitudes of genetic similarity of isolates from sexual and asexual phases. These results support the hypothesis that recombination plays an important role in determining the amplitude of variability in this pathogen population and that this determination occurs on a fine scale.

  13. Educational utilization of outstanding spherulitic rhyolite occurred in Cheongsong, Korea

    Science.gov (United States)

    Jang, Y. D.; Woo, H.

    2015-12-01

    Cheongsong is located in the central eastern area of South Korea. Unique spherulitic rhyolites occur in this region as dykes formed about 48 to 50 million years ago. Composed of quartz and feldspar these spherulitic rhyolites show various flowerlike shapes, such as chrysanthemum, dandelion, rose, carnation, sunflower, dahlia and so on, so they are called 'flower stones'. The spherulite indicates that it was undercooled caused by very fast cooling at a shallow depth near the surface and the variety of shapes resulted from the difference of crystallizing conditions. According to the condition, minerals start to crystallize homogeneously or heterogeneously and develop as rounded or fibrous shapes, representing beautiful patterns when combined. These spherulitic structures are very rare not only in Korea but also globally, being valuable for research and preservation because of their rarity, beauty and diversity. Cheongsong therefore applies to the UGG (UNESCO Global Geopark) in an attempt to popularize the flower stones and use them as education materials which can also be incorporated in other valuable sites. The exhibition center provides diverse types of flower stones in which visitors could learn about rhyolitic volcanism, crystallization and spherulite and can experience the process of changing a rough stone into a flower stone. A geotrail course has also been created, showing each type of flower stone on the outcrop and providing educational programs about geological mechanisms of the stones with a trained guide.

  14. Immunomodulatory effects in workers exposed to naturally occurring asbestos fibers.

    Science.gov (United States)

    Ledda, Caterina; Costa, Chiara; Matera, Serena; Puglisi, Beatrice; Costanzo, Valentina; Bracci, Massimo; Fenga, Concettina; Rapisarda, Venerando; Loreto, Carla

    2017-05-01

    Natural asbestiform fibers are defined 'naturally occurring asbestos' (NOA) and refer to the mineral as a natural component of soils or rocks. The release of NOA fibers into the air from rocks or soils by routine human activities or natural weathering processes represents a risk for human beings. Fluoro-edenite (FE) is a NOA fiber detected in the benmoreitic lava in the area of Biancavilla, South-west slope of Mt. Etna. The aim of the present study was to investigate FE immunotoxicity pathways in a group of 38 occupationally exposed construction workers, in order to find any biological markers of its effect. Subjects underwent respiratory function tests and HRCT total chest scanning. Serum IL-1β, IL-6, IL-8 and TNF-α were measured. The presence of PPs was significantly greater in subjects exposed than in the control (25 vs. 2). In subjects exposed to FE, IL-1β and TNF-α values were significantly higher than the controls. The previously observed increase of IL-1β and IL-18 showed a probable involvement of the proteic complex defined inflammosome by FE fibers.

  15. Naturally occuring radiation in the Nordic countries - recommendations

    International Nuclear Information System (INIS)

    1986-01-01

    In the publication ''Report on the Applicability of International Radiation Protection Recommendations in the Nordic Countries'', published in 1976, the radiation protection authorities in Denmark, Finland, Iceland, Norway and Sweden expessed their agreement on the main principles of radiation protection. The general aspects of radiation protection were covered in the recommendations with the exception of exposure of the public from natural sources of radiation. In 1983 a working group published the report ''Naturally Occurring radiation in the Nordic Countries, - Levels'' in the Radiation Protection Information-Series from the Nordic countries. In that report the present knowledge of the population exposure from natural sources of external gamma-radiation and from radon and thoron daughters in air was reviewed as a basis for the development of the radiation protection recommendations for natural radiation. During preparation of these recommendations due account has also been taken of ICRP publication no. 39: ''Principles for Limiting Exposure of the Public to Natural Sources of Radiation'', which was published in 1984 and in which ICRP for the first time has issued more specific recommendations for natural sources. The recommendations may serve as a basis for more formal rules and regulations within each country, if this is seemed necessary. However, no attempt has been made to formulate identical rules for all the five countries since the exposure levels from natural sources, methods of application and the legal frameworks differ between the countries. (EG)

  16. Green oysters occurring in an industrial harbor in Central Taiwan.

    Science.gov (United States)

    Fang, Tien-Hsi; Dai, Shi-Yan

    2017-11-30

    Green oysters were found within the Mailiao industrial harbor (MIH) located in Central Taiwan. The metal concentrations in seawater (dissolved and particulate phases), sediment and oyster samples collected within the MIH were analyzed to examine the green oysters. The dissolved and particulate metal concentrations ranged within 0.008-1.47μgl -1 and 0.97-799.2mgkg -1 , respectively. The Cu concentration in seawater was dominated in the dissolved phase. In contrast, Cr, Pb and Zn in seawater were chiefly present in the particulate phase. The metal concentrations in sediment and oyster samples ranged within 0.02-148.4mgkg -1 and 0.18-1238mgkg -1 (dry W.), respectively. No anomalous values were found in the analyzed samples, except the Cu content in the oyster samples ranged within 274-1238mgkg -1 . The relatively high bioconcentration factor of Cu in oyster and the longer exposure time induced the green oysters occurred within the MIH. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Occurance and distribution of poty viruses infecting garlic in Pakistan

    International Nuclear Information System (INIS)

    Gilani, S.T.; Hameed, S.; Shah, H.

    2016-01-01

    The study was designed to detect and determine the prevalence, incidence and distribution of the poty viruses causing diseases in garlic (Allium sativum) from major garlic growing areas of Pakistan. The yellow stripes, mosaic and chlorotic spot symptoms of the disease resemble the viral infection in garlic reported to occur worldwide. Altogether 690 samples were collected from 29 locations of Punjab and 40 locations of Khyber Pukhtunkhwa to determine the prevalence of Onion Yellow Dwarf Virus (OYDV) and Leek Yellow Stripe Virus (LYSV). Serological testing DAS-ELISA technique was used to test the samples collected from the farmer fields. Based on the DAS-ELISA poty viruses OYDV and LYSV were detected from both provinces although the percentage incidence varied from location to location. Few areas of district Punjab were found free of LYSV but OYDV was prevalent in all locations irrespective of the varieties cultivated. Maximum disease incidence was detected in Swabi (KPK) where OYDV was 90percent and LYSV was 38 percent while in Punjab major disease incidence of OYDV (87.14 percent) and LYSV (91.44 percent) was found in Sialkot. (author)

  18. Pioneer round of translation occurs during serum starvation

    International Nuclear Information System (INIS)

    Oh, Nara; Kim, Kyoung Mi; Cho, Hana; Choe, Junho; Kim, Yoon Ki

    2007-01-01

    The pioneer round of translation plays a role in translation initiation of newly spliced and exon junction complex (EJC)-bound mRNAs. Nuclear cap-binding protein complex CBP80/20 binds to those mRNAs at the 5'-end, recruiting translation initiation complex. As a consequence of the pioneer round of translation, the bound EJCs are dissociated from mRNAs and CBP80/20 is replaced by the cytoplasmic cap-binding protein eIF4E. Steady-state translation directed by eIF4E allows for an immediate and rapid response to changes in physiological conditions. Here, we show that nonsense-mediated mRNA decay (NMD), which restricts only to the pioneer round of translation but not to steady-state translation, efficiently occurs even during serum starvation, in which steady-state translation is drastically abolished. Accordingly, CBP80 remains in the nucleus and processing bodies are unaffected in their abundance and number in serum-starved conditions. These results suggest that mRNAs enter the pioneer round of translation during serum starvation and are targeted for NMD if they contain premature termination codons

  19. How Condom Discontinuation Occurs: Interviews With Emerging Adult Women.

    Science.gov (United States)

    Mullinax, Margo; Sanders, Stephanie; Dennis, Barbara; Higgins, Jenny; Fortenberry, J Dennis; Reece, Michael

    We have almost no data on how and when couples stop using condoms. This qualitative study investigated the process of condom discontinuation. From November 2013 to April 2014, a total of 25 women living in a college town in the Midwest, ages 18 to 25, participated in semistructured interviews centered around three domains: partner interactions, contraceptive use, and sexually transmitted infection (STI) prevention. Analysis followed a critical qualitative research orientation. Participants described actively seeking the best options to prevent pregnancy, perceiving condom discontinuation in favor of hormonal methods as a smart decision, and reported wanting to discontinue using condoms due to physical discomfort. Oftentimes, nonverbal communication around contextual instances of condom unavailability paved the way for discontinuation. Participants indicated the decision to stop using condoms was neither deliberate nor planned. Condom discontinuation rarely occurred at one point in time; instead, it was preceded by a period of occasional use. Even after participants described themselves as not using condoms, sporadic condom use was normal (typically related to fertility cycles). This study provides a more detailed understanding of how and why emerging adults negotiate condom discontinuation, thereby enhancing our ability to design effective condom continuation messages. Attention should be paid to helping emerging adults think more concretely about condom discontinuation.

  20. Characteristics of schools in which fatal shootings occur.

    Science.gov (United States)

    de Apodaca, Roberto Flores; Brighton, Lauren M; Perkins, Ashley N; Jackson, Kiana N; Steege, Jessica R

    2012-04-01

    School-based violence, and fatal school shootings in particular, have gained increased attention in the media and psychological literature. Most reports have focused on the characteristics of perpetrators, but there is a growing awareness that school-related factors may also influence the occurrence of fatal school shootings. The current study examined several key characteristics of all schools where random (38) and targeted (96) fatal shootings occurred in the United States between 1966 and 2009. These were compared with a group (138) of schools randomly selected to represent the population of all schools in the United States. The size of a school's enrollment, urban or suburban locale, public funding, and predominantly non-white enrollment were positively associated with fatal shootings. Universities and colleges were disproportionately associated with random shootings and high schools with targeted ones. It was proposed that characteristics of schools that allow feelings of anonymity or alienation among students may help create environmental conditions associated with fatal school shootings. Implications for future research and interventions are considered.

  1. Conformational Flexibility Differentiates Naturally Occurring Bet v 1 Isoforms

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    Sarina Grutsch

    2017-06-01

    Full Text Available The protein Bet v 1 represents the main cause for allergic reactions to birch pollen in Europe and North America. Structurally homologous isoforms of Bet v 1 can have different properties regarding allergic sensitization and Th2 polarization, most likely due to differential susceptibility to proteolytic cleavage. Using NMR relaxation experiments and molecular dynamics simulations, we demonstrate that the initial proteolytic cleavage sites in two naturally occurring Bet v 1 isoforms, Bet v 1.0101 (Bet v 1a and Bet v 1.0102 (Bet v 1d, are conformationally flexible. Inaccessible cleavage sites in helices and strands are highly flexible on the microsecond-millisecond time scale, whereas those located in loops display faster nanosecond-microsecond flexibility. The data consistently show that Bet v 1.0102 is more flexible and conformationally heterogeneous than Bet v 1.0101. Moreover, NMR hydrogen-deuterium exchange measurements reveal that the backbone amides in Bet v 1.0102 are significantly more solvent exposed, in agreement with this isoform’s higher susceptibility to proteolytic cleavage. The differential conformational flexibility of Bet v 1 isoforms, along with the transient exposure of inaccessible sites to the protein surface, may be linked to proteolytic susceptibility, representing a potential structure-based rationale for the observed differences in Th2 polarization and allergic sensitization.

  2. Naturally occurring glasses: analogues for radioactive waste forms

    International Nuclear Information System (INIS)

    Ewing, R.C.; Haaker, R.F.

    1979-04-01

    Volcanic glasses are very often altered by weathering and leaching and recrystallize to their fine-grained equivalents (rhyolites, felsites). The oldest volcanic glasses are dated at 40 million years before the present, but the majority are much younger. Devitrification textures was produced experimentally; and hydration rates for volcanic glasses were determined as a function of composition, temperature, and climate. Presence of water and temperature are the most important rate controlling variables. Even material that may still be described as glassy often exhibits evidence of alteration and recrystallization. Of the volcanic glasses that are preserved in the geologic record, it would be rare to describe such a glass as pristine. Despite the common alteration and recrystallization effects observed in volcanic glasses, glasses formed as a result of impact, tektites and lunar glasses, may occur in substantially unaltered form. In the case of tektites, their resistance to alteration is a result of their high SiO 2 content and low alkali content. Lunar glasses have been preserved for hundreds of millions of years because they exist in an environment with a low oxygen fugacity and an extremely low water vapor partial presssure. Thus one might expect glasses of particular compositions or in specific types of environment to be stable for long periods of time. These conclusions are applied to radioactive waste disposal over several time periods

  3. Naturally occurring allele diversity allows potato cultivation in northern latitudes.

    Science.gov (United States)

    Kloosterman, Bjorn; Abelenda, José A; Gomez, María del Mar Carretero; Oortwijn, Marian; de Boer, Jan M; Kowitwanich, Krissana; Horvath, Beatrix M; van Eck, Herman J; Smaczniak, Cezary; Prat, Salomé; Visser, Richard G F; Bachem, Christian W B

    2013-03-14

    Potato (Solanum tuberosum L.) originates from the Andes and evolved short-day-dependent tuber formation as a vegetative propagation strategy. Here we describe the identification of a central regulator underlying a major-effect quantitative trait locus for plant maturity and initiation of tuber development. We show that this gene belongs to the family of DOF (DNA-binding with one finger) transcription factors and regulates tuberization and plant life cycle length, by acting as a mediator between the circadian clock and the StSP6A mobile tuberization signal. We also show that natural allelic variants evade post-translational light regulation, allowing cultivation outside the geographical centre of origin of potato. Potato is a member of the Solanaceae family and is one of the world's most important food crops. This annual plant originates from the Andean regions of South America. Potato develops tubers from underground stems called stolons. Its equatorial origin makes potato essentially short-day dependent for tuberization and potato will not make tubers in the long-day conditions of spring and summer in the northern latitudes. When introduced in temperate zones, wild material will form tubers in the course of the autumnal shortening of day-length. Thus, one of the first selected traits in potato leading to a European potato type is likely to have been long-day acclimation for tuberization. Potato breeders can exploit the naturally occurring variation in tuberization onset and life cycle length, allowing varietal breeding for different latitudes, harvest times and markets.

  4. Shear zone-related pseudotachylite occurences from the northern Transvaal

    International Nuclear Information System (INIS)

    Reimold, W.U.; Meyer, F.M.

    1990-01-01

    Pseudotachylite from the Sand River localities displays very variable composition when formed in Sand River Gneiss, but is less variable when originating from diabase. Comparison of individual pseudotachylite (granitic) host rock pairs shows consistent depletion and enrichment. Rather high LoI values indicate significant secondary alteration for some specimens. The chemical variations agree well with the theory that pseudotachylite in granitic-granodioritic environment is formed by preferential melting of hydrous ferromagnesian minerals plus varied proportions of feldspar components. 'Basaltic' pseudotachylite is characterised by increase of SiO 2 and K 2 O, which is also known from other occurences. With respect to most trace elements, pseudotachylite is generally enriched. Comparison of all pseudotachylite analyses with Sand River Gneiss data reveals that mixing on a dm scale cannot be completely excluded, but 'basaltic' pseudotachilyte obtained in granodioritic host rock has not assimilated more than approximately 5% of felsic material. The cataclastic breccias chemically compare well with undeformed Sand River Gneiss. These results agree well with current theory on pseudotachylite formation, but at the Geocongress a larger data base will be discussed. 1 fig., 6 refs

  5. Characteristics of Watermelon Mosaic Virus Transmission Occurring in Korean Ginseng

    Directory of Open Access Journals (Sweden)

    Seung-Kook Choi

    2014-09-01

    Full Text Available Korean ginseng (Panax ginseng is the most popular herb for medical purpose in Korea. Recently, viral diseases from Korean ginseng showing various degrees of severe mottling, variegation and mosaic symptoms have caused quantity losses of Korean ginseng in a large number of farms. Watermelon mosaic virus (named WMVgin was identified as a causal agent for the disease of Korean ginseng. Interestingly, WMV-gin failed to infect both Korean ginseng plant and susceptible host species including cucurbitaceous plants by mechanical inoculation. However, WMV-gin could successfully infect Korean ginseng by transmission of two aphid species (Myzus persicae and Aphis gossypii. It is likely that transmission of WMV-gin was done by both the aphid species during feeding behavior of the two aphid species on Korean ginseng, though the aphids dislike feeding in Korea ginseng. Similarly, a strain of WMV (WMV-wm isolated from watermelon was transmitted successfully to Korean ginseng plant by the two aphid species, but not by mechanical inoculations. Transmission assays using M. persicae and A. gossypii clearly showed both WMV-gin and WMV-wm were not transmitted from infected Korean ginseng plant to cucurbit species that are good host species for WMV. These results suggest WMV disease occurring in Korean ginseng plant can be controlled by ecological approaches.

  6. CooVar: Co-occurring variant analyzer

    Directory of Open Access Journals (Sweden)

    Vergara Ismael A

    2012-11-01

    Full Text Available Abstract Background Evaluating the impact of genomic variations (GV on protein-coding transcripts is an important step in identifying variants of functional significance. Currently available programs for variant annotation depend on external databases or annotate multiple variants affecting the same transcript independently, which limits program use to organisms available in these databases or results in potentially incorrect or incomplete annotations. Findings We have developed CooVar (Co-occurring Variant Analyzer, a database-independent program for assessing the impact of GVs on protein-coding transcripts. CooVar takes GVs, reference genome sequence, and protein-coding exons as input and provides annotated GVs and transcripts as output. Other than similar programs, CooVar considers the combined impact of all GVs affecting the same transcript, generating biologically more accurate annotations. CooVar is operated from the command-line and supports standard file formats VCF, GFF/GTF, and GVF, which makes it easy to integrate into existing computational pipelines. We have extensively tested CooVar on worm and human data sets and demonstrate that it generates correct annotations in only a short amount of time. Conclusions CooVar is an easy-to-use and lightweight variant annotation tool that considers the combined impact of GVs on protein-coding transcripts. CooVar is freely available at http://genome.sfu.ca/projects/coovar/.

  7. Homeostatic roles of naturally occurring antibodies: an overview.

    Science.gov (United States)

    Lutz, Hans U

    2007-12-01

    Immunoglobulins may have been developed in evolution to provide specificity for clearing body waste in the first animals with three germ layers. Tissue homeostasis in vertebrates comprises clearance of proteins released from lysed cells, elimination of altered plasma proteins, of senescent and apoptotic cells. Rather specific IgM and IgG naturally occurring antibodies (NAbs) to cytoplasmic and cytoskeletal proteins bind to proteins released from lysing cells and the IgG NAbs are slightly upregulated upon demand. Some of these NAbs along with complement have devastating effects when massive amounts of intracellular proteins are released during an infarct or an ischemia/reperfusion experiment. IgM NAbs to neoepitopes on plasma proteins/lipids help clear denatured proteins and are protective. IgG NAbs to an exposed protein, band 3 from red blood cells, bind to oligomerized band 3 and due to an affinity for C3 within their framework preferentially form C3b2-IgG complexes from nascent C3b. Thus, anti-band 3 NAbs gain potency by using avidity and generating a potent precursor of the amplifying C3 convertase. IgM NAbs to neoepitopes, which are generated by oxidized lipids forming Schiff bases with proteins, are protective and help clear this waste in atherosclerosis, but IgG antibodies (NAbs?) of the same specificity promote disease.

  8. Mathematical modelling of the landslide occurred at Gagliano Castelferrato (Italy

    Directory of Open Access Journals (Sweden)

    M. Maugeri

    2006-01-01

    Full Text Available Shallow slopes in clayey colluvial covers are often involved in progressive downhill motion with discontinuous rate of movements, depending on fluctuations in pore-water pressure. In geotechnical engineering research on natural slopes, the main efforts have been concentrated on stability analysis, always with a rigid perfectly plastic body assumption. In case of slow slope movements, however, the notion of stability losses its sense, so the main question is not to evaluate a stability factor, but to model a velocity field and to define the kinematic and dynamic features of the movement (mobility analysis. Many authors, in their researches, deal with slow slope movements and for the complexity of the problem and the great number of parameters involved they agree about applying numerical techniques (FEM, FDM and advanced material modelling (elastoviscoplasticity and suggest to calibrate the involved parameters values with the help of ''back analyses'' of existing case histories. In this paper a mathematical model predicting the landslide body viscous deformations, is presented. The model has been implemented in a computer FDM code, and has been tested on some well known case histories. Here it is applied to the case of a landslide occurred at Gagliano Castelferrato (Sicily – Italy, where a great number of field measurements was available.

  9. Naturally occurring and accelerator-produced radioactive materials: 1987 review

    International Nuclear Information System (INIS)

    Austin, J.H.

    1988-03-01

    From time to time, the issue as to whether the US Nuclear Regulatory Commission (NRC) should seek legislative authority to regulate naturally occurring and accelerator-produced radioactive materials (NARM) is raised. Because NARM exists in the environment, in homes, in workplaces, in medical institutions, and in consumer products, the issue of Federal controls over NARM is very old and very complex. This report presents a review of NARM sources and uses as well as incidents and problems associated with those materials. A review of previous congressional and Federal agency actions on radiation protection matters, in general, and on NARM, in particular, is provided to develop an understanding of existing Federal regulatory activity in ionizing radiation and in control of NARM. In addition, State controls over NARM are reviewed. Eight questions are examined in terms of whether the NRC should seek legislative authority to regulate NARM. The assessment of these questions serves as the basis for developing and evaluating five options. The evaluation of those options leads to two recommendations

  10. GROWTH OF NATURALLY OCCURING Listeria innocua IN COPPA DI TESTA

    Directory of Open Access Journals (Sweden)

    G. Merialdi

    2010-06-01

    Full Text Available Coppa di testa is a traditional cooked pork salami produced in different Italian regions. The main raw material is deboned meat of pork head with the addition of tongue and rind. After a long (3-5 h high temperature (97°C cooking, additives and flavourings are added and the salami is prepared. After cooling the salami is often portioned and vacuum- packaged. In this study the growth of naturally occurring contamination of Listeria innocua in three batches of vacuum packaged Coppa di testa, stored at 4°C for 80 days, is described. The average max was 0.24 (days-1 and the average doubling time was 2.87 days. The maximum growth level ranged from 4.90 to 8.17 (log10 cfu/g. These results indicate that Coppa di testa definitely supports the growth of Listeria innocua in the considered storage conditions. Taking into account that at 4°C Listeria monocytogenes strains are associated with higher grow rates than L. innocua, these results emphasize the importance of preventing Listeria monocytogenes contamination in the production stages following cooking.

  11. Characterization of naturally occurring airborne diacetyl concentrations associated with the preparation and consumption of unflavored coffee

    Directory of Open Access Journals (Sweden)

    Jennifer S. Pierce

    2015-01-01

    Full Text Available Diacetyl, a suspected cause of respiratory disorders in some food and flavorings manufacturing workers, is also a natural component of roasted coffee. We characterized diacetyl exposures that would plausibly occur in a small coffee shop during the preparation and consumption of unflavored coffee. Personal (long- and short-term and area (long-term samples were collected while a barista ground whole coffee beans, and brewed and poured coffee into cups. Simultaneously, long-term personal samples were collected as two participants, the customers, drank one cup of coffee each per h. Air sampling and analyses were conducted in accordance with OSHA Method 1012. Diacetyl was detected in all long-term samples. The long-term concentrations for the barista and area samples were similar, and ranged from 0.013–0.016 ppm; long-term concentrations for the customers were slightly lower and ranged from 0.010–0.014 ppm. Short-term concentrations ranged from below the limit of detection (<0.0047 ppm–0.016 ppm. Mean estimated 8 h time-weighted average (8 h TWA exposures for the barista ranged from 0.007–0.013 ppm; these values exceed recommended 8 h TWA occupational exposure limits (OELs for diacetyl and are comparable to long-term personal measurements collected in various food and beverage production facilities. The concentrations measured based on area sampling were comparable to those measured in the breathing zone of the barista, thus exceedances of the recommended OELs may also occur for coffee shop workers who do not personally prepare coffee (e.g., cashier, sanitation/maintenance. These findings suggest that the practicality and scientific basis of the recommended OELs for diacetyl merit further consideration.

  12. Public Health Goal for Naturally Occurring Radionuclides in Groundwater

    International Nuclear Information System (INIS)

    Kamel, N.H.M.; Omar, H.A.; El-Baset, L.A.

    2008-01-01

    Naturally occurring and man-made radionuclide in groundwater may have a health hazardous to some residents. The objective of this work is to provide criteria for safety of drinking-water with respect to the chemical parameters and the radionuclide content. The annual effective dose for the consumption of drinking water was considered. Ground water samples were selected from different sites in Egypt, that have the most population, it were taken from aquifer regions along Giza sites in Egypt. Chemical analyses for the major anions, cations, and the radiological analyses were tested . Activity concentrations (Bq/l) of the gross alpha and the gross beta activities of our investigated samples were compared with the maximum contaminant level (MCL) of the world health organization (WHO). Some of the water samples were found to have a higher of gross beta and alpha particles than the MCL. Alpha activity were found depending on to the total dissolved solids (TDS) content of the water samples. Gamma activity concentrations were analyzed using low background germanium detector, the higher of activity values was found in some investigated samples is due to increasing of 226 Ra and 228 Ra activities. Tritium activity concentrations also were measured using soft beta liquid scintillation counter, it was found lower than the MCL. Our investigated samples were found to have a higher concentrations of the phosphate, nitrites, iron, and manganese contents than the maximum permissible limit, all the ground water samples were found to have a higher of silica and alumina content. Commercial carbon powder and natural clay materials were tested as ion exchangers for the removal of inorganic contaminants in the ground water samples. Clay materials was found to have a higher selectivity than activated carbon for the removal of radionuclides, phosphates, nitrites, and manganese content at the ground water samples

  13. Numerical analysis of an intense rainstorm occurred in southern Italy

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    S. Federico

    2008-01-01

    Full Text Available In this study we conduct a numerical analysis of an intense and destructive storm that occurred over Calabria, southern Italy, on 10–12 December 2003. More than 250 mm of precipitation was recorded over a large area in southern Calabria and one station reported about 660 mm in two days (more than half of the yearly climatological value. Precipitation fell mainly during 11 and 12 December. The storm was characterized by the entrance of an Atlantic upper-level trough associated with a deep surface low that advected humid marine air toward steep Calabrian orography. The steep mountain ridges favoured landslides, which were reported in several villages. Property damage was extensive.

    We study the storm at the mesoscale by means of the Regional Atmospheric Modeling System (RAMS. The model was successful at representing the observed accumulated rainfall patterns. This justifies our use of RAMS for further analysis of the physical and dynamic factors involved in the storm event. In particular, we use RAMS to evaluate the roles of Calabrian orography, surface latent heat flux, and upper level forcing.

    The key role of a potential vorticity (PV streamer, which forced the entire meteorological system from the upper levels is assessed by the PV inversion technique in a Limited Area Model Ensemble Prediction System (LEPS framework.

    Results show that the roles of Calabrian orography and surface latent heat flux are important in our simulations. Indeed, humid marine air masses were advected by the synoptic flow toward Calabrian steep coastal mountain ranges determining intense and abundant rainfall.

  14. Neurobiology of mammalian olfactory learning that occurs during sensitive periods

    Directory of Open Access Journals (Sweden)

    Hideto KABA

    2010-12-01

    Full Text Available This review examines the organizational principles underlying olfactory learning in three specialized contexts that occur during sensitive periods of enhanced neural plasticity and emphasizes some of their common features. All three forms of olfactory learning are associated with neural changes in the olfactory bulb (OB at the first stage of sensory processing. These changes require the association of the olfactory and somatosensory signals in the OB. They all depend on somatosensory stimulation-induced release of noradrenaline that induces structural and functional changes at mitral-granule cell reciprocal synapses in the OB, resulting in increases in inhibitory transmission. In the accessory olfactory bulb, this represents the enhanced self-inhibition of mitral cells, which selectively disrupts the transmission of the mating male’s pregnancy-blocking signal at this level. In contrast, an extensive network of secondary dendrites of mitral cells in the main olfactory bulb probably results in a sharpening of the odor-induced pattern of activity, due to increases in lateral inhibition, leading to offspring recognition in sheep and neonatal learning in rats and rabbits. These findings show that inhibitory interneurons play a critical role in olfactory learning. Further work on how these neurons shape olfactory circuit function could provide important clues to understand memory functions of interneurons in other systems. Moreover, recent research has suggested that three forms of olfactory learning are controlled by synergistic, redundant, and distributed neural mechanisms. This has general implications regarding the mechanisms that may contribute to the robustness of memories [Current Zoology 56 (6: 819–833, 2010].

  15. Why Does REM Sleep Occur? A Wake-up Hypothesis

    Directory of Open Access Journals (Sweden)

    Dr. W. R. eKlemm

    2011-09-01

    Full Text Available Brain activity differs in the various sleep stages and in conscious wakefulness. Awakening from sleep requires restoration of the complex nerve impulse patterns in neuronal network assemblies necessary to re-create and sustain conscious wakefulness. Herein I propose that the brain uses REM to help wake itself up after it has had a sufficient amount of sleep. Evidence suggesting this hypothesis includes the facts that, 1 when first going to sleep, the brain plunges into Stage N3 (formerly called Stage IV, a deep abyss of sleep, and, as the night progresses, the sleep is punctuated by episodes of REM that become longer and more frequent toward morning, 2 conscious-like dreams are a reliable component of the REM state in which the dreamer is an active mental observer or agent in the dream, 3 the last awakening during a night’s sleep usually occurs in a REM episode during or at the end of a dream, 4 both REM and awake consciousness seem to arise out of a similar brainstem ascending arousal system 5 N3 is a functionally perturbed state that eventually must be corrected so that embodied brain can direct adaptive behavior, and 6 corticofugal projections to brainstem arousal areas provide a way to trigger increased cortical activity in REM to progressively raise the sleeping brain to the threshold required for wakefulness. This paper shows how the hypothesis conforms to common experience and has substantial predictive and explanatory power regarding the phenomenology of sleep in terms of ontogeny, aging, phylogeny, abnormal/disease states, cognition, and behavioral physiology. That broad range of consistency is not matched by competing theories, which are summarized herein. Specific ways to test this wake-up hypothesis are suggested. Such research could lead to a better understanding of awake consciousness.

  16. Combustion of crude oil sludge containing naturally occurring radioactive material

    International Nuclear Information System (INIS)

    Mohamad Puad Abu; Muhd Noor Muhd Yunus; Shamsuddin, A.H.; Sopian, K.

    2000-01-01

    The characteristics of crude oil sludge fi-om the crude oil terminal are very unique because it contains both heavy metals and also Naturally Occurring Radioactive Material (NORM). As a result, the Department of Environmental (DOE) and the Atomic Energy Licensing Board (AELB) considered it as Scheduled Wastes and Low Level Radioactive Waste (LLRW) respectively. As a Scheduled Wastes, there is no problem in dealing with the disposal of it since there already exist a National Center in Bukit Nanas to deal with this type of waste. However, the Center could not manage this waste due to the presence of NORM by which the policy regarding the disposal of this kind of waste has not been well established. This situation is unclear to certain parties, especially with respect to the relevant authorities having final jurisdiction over the issue as well as the best practical method of disposal of this kind of waste. Existing methods of treatment viewed both from literature and current practice include that of land farming, storing in plastic drum, re-injection into abandoned oil well, recovery, etc., found some problems. Due to its organic nature, very low level in radioactivity and the existence of a Scheduled Waste incineration facility in Bukit Nanas, there is a potential to treat this sludge by using thermal treatment technology. However, prior to having this suggestion to be put into practice, there are issues that need to be addressed. This paper attempts to discuss the potentials and the related issues of combusting crude oil sludge based on existing experimental data as well as mathematical modeling

  17. Why does rem sleep occur? A wake-up hypothesis.

    Science.gov (United States)

    Klemm, W R

    2011-01-01

    Brain activity differs in the various sleep stages and in conscious wakefulness. Awakening from sleep requires restoration of the complex nerve impulse patterns in neuronal network assemblies necessary to re-create and sustain conscious wakefulness. Herein I propose that the brain uses rapid eye movement (REM) to help wake itself up after it has had a sufficient amount of sleep. Evidence suggesting this hypothesis includes the facts that, (1) when first going to sleep, the brain plunges into Stage N3 (formerly called Stage IV), a deep abyss of sleep, and, as the night progresses, the sleep is punctuated by episodes of REM that become longer and more frequent toward morning, (2) conscious-like dreams are a reliable component of the REM state in which the dreamer is an active mental observer or agent in the dream, (3) the last awakening during a night's sleep usually occurs in a REM episode during or at the end of a dream, (4) both REM and awake consciousness seem to arise out of a similar brainstem ascending arousal system (5) N3 is a functionally perturbed state that eventually must be corrected so that embodied brain can direct adaptive behavior, and (6) cortico-fugal projections to brainstem arousal areas provide a way to trigger increased cortical activity in REM to progressively raise the sleeping brain to the threshold required for wakefulness. This paper shows how the hypothesis conforms to common experience and has substantial predictive and explanatory power regarding the phenomenology of sleep in terms of ontogeny, aging, phylogeny, abnormal/disease states, cognition, and behavioral physiology. That broad range of consistency is not matched by competing theories, which are summarized herein. Specific ways to test this wake-up hypothesis are suggested. Such research could lead to a better understanding of awake consciousness.

  18. Covalent DNA-protein crosslinking occurs after hyperthermia and radiation

    International Nuclear Information System (INIS)

    Cress, A.E.; Bowden, G.T.

    1983-01-01

    Covalent DNA-protein crosslinks occur in exponentially growing mouse leukemia cells (L1210) after exposure to ionizing radiation. The amount of DNA-protein crosslinks as measured by a filter binding assay is dose dependent upon x irradiation. Although hyperthermia and radiation in combination are synergistic with respect to cell lethality, the combination does not result in an increase of DNA-protein crosslinks when assayed immediately following treatments. Hyperthermia (43 0 C/15 min) given prior to radiation dose not alter the radiation dose dependency of the amount of initial crosslinking. In addition, the amount of DNA-protein crosslinking produced by heat plus radiation is independent of the length of heating the cells at 43 0 C. The DNA-protein crosslinks produced y 50-Gy x ray alone are removed after 2 hr at 37 0 C. However, if hyperthermia (43 0 C/15 min) is given prior to 100-Gy x ray, the removal of DNA-protein crosslinks is delayed until 4.0 hr after radiation. Phospho-serine and phospho-threonine bonds are not produced with either radiation or the combination of hyperthermia plus radiation as judged by the resistance of the bonds to guanidine hydrochloride. However, hyperthermia plus radiation causes an increase in phosphate to nitrogen type bonding. These results show that radiation alone causes covalent DNA-protein crosslinks. Hyperthermia in combination with radiation does not increase the total amount of the crosslinks but delays the removal of the crosslinks and alters the distribution of the types of chemical bonding

  19. Covalent DNA-protein crosslinking occurs after hyperthermia and radiation

    International Nuclear Information System (INIS)

    Cress, A.E.; Bowden, G.T.

    1983-01-01

    Covalent DNA-protein crosslinks occur in exponentially growing mouse leukemia cells (L1210) after exposure to ionizing radiation. The amount of DNA-protein crosslinks as measured by a filter binding assay is dose dependent upon X irradiation. Although hyperthermia and radiation in combination are synergistic with respect to cell lethality, the combination does not result in an increase of DNA-protein crosslinks when assayed immediately following treatments. Hyperthermia (43 degrees C/15 min) given prior to radiation does not alter the radiation dose dependency of the amount of initial crosslinking. In addition, the amount of DNA-protein crosslinking produced by heat plus radiation is independent of the length of heating the cells at 43 degrees C. The DNA-protein crosslinks produced by 50-Gy X ray alone are removed after 2 hr at 37 degrees C. However, if hyperthermia (43 degrees C/15 min) is given prior to 100-Gy X ray, the removal of DNA-protein crosslinks is delayed until 4.0 hr after radiation. Phospho-serine and phospho-threonine bonds are not produced with either radiation or the combination of hyperthermia plus radiation as judged by the resistance of the bonds to guanidine hydrochloride. However, hyperthermia plus radiation causes an increase in phosphate to nitrogen type bonding. These results show that radiation alone causes covalent DNA-protein crosslinks. Hyperthermia in combination with radiation does not increase the total amount of the crosslinks but delays the removal of the crosslinks and alters the distribution of the types of chemical bonding. These data suggest that the synergistic action on hyperthermia with radiation is more related to the rate of removal and the type of chemical bonding involved in the covalent DNA-protein crosslinks rather than the amount of DNA-protein crosslinks

  20. Nitric oxide metabolites in naturally occurring canine babesiosis.

    Science.gov (United States)

    Jacobson, Linda S; Lobetti, Remo G; Becker, Pieter; Reyers, Fred; Vaughan-Scott, Tarquin

    2002-02-27

    Babesiosis, caused by the virulent haemoprotozoan parasite Babesia canis rossi, is an important disease of dogs in South Africa. The nitric oxide metabolites, nitrate and nitrite (collectively termed reactive nitrogen intermediates or RNIs) were measured in admission sera from dogs in a babesiosis-endemic area. Five groups were prospectively studied: mild uncomplicated (n=9), severe uncomplicated (severe anaemia) (n=10) and complicated babesiosis (n=11); and two groups of healthy aparasitaemic dogs: endemic controls from the study area (n=10) and experimental dogs kept in tick-free conditions (n=10). Four measures of RNI production were studied: (i) serum RNI; (ii) serum RNI/creatinine ratio; (iii) fractional clearance of RNI (FC(RNI)); (iv) fractional excretion of RNI (FE(RNI)). Marked elevations of serum RNI occurred in only two dogs, both in the severe uncomplicated group. The highest concentration (log value 5.29 micromol/l) was in a dog that died, but concentrations in the other four dogs that died were unremarkable (0, 0.34, 1.66 and 2.64 micromol/l). Age, appetite and free serum haemoglobin were significant covariates for measures of RNI production. There were no significant differences among the babesiosis groups for serum RNI. Adjustment for creatinine had minor effects on the results. All babesiosis groups had significantly higher serum RNI and RNI/creatinine than the tick-free control group, but did not differ from the endemic controls except for the severe uncomplicated group, which had higher RNI/creatinine. The complicated group had significantly lower FC(RNI) and FE(RNI) than all other groups, except for the tick-free control group, which had similar FE(RNI). The results indicate that, in an endemic area, measures of RNI production are unlikely to be useful indicators of severity or outcome in canine babesiosis.

  1. Cognitive dysfunction in naturally occurring canine idiopathic epilepsy.

    Directory of Open Access Journals (Sweden)

    Rowena M A Packer

    Full Text Available Globally, epilepsy is a common serious brain disorder. In addition to seizure activity, epilepsy is associated with cognitive impairments including static cognitive impairments present at onset, progressive seizure-induced impairments and co-morbid dementia. Epilepsy occurs naturally in domestic dogs but its impact on canine cognition has yet to be studied, despite canine cognitive dysfunction (CCD recognised as a spontaneous model of dementia. Here we use data from a psychometrically validated tool, the canine cognitive dysfunction rating (CCDR scale, to compare cognitive dysfunction in dogs diagnosed with idiopathic epilepsy (IE with controls while accounting for age. An online cross-sectional study resulted in a sample of 4051 dogs, of which n = 286 had been diagnosed with IE. Four factors were significantly associated with a diagnosis of CCD (above the diagnostic cut-off of CCDR ≥50: (i epilepsy diagnosis: dogs with epilepsy were at higher risk; (ii age: older dogs were at higher risk; (iii weight: lighter dogs (kg were at higher risk; (iv training history: dogs with more exposure to training activities were at lower risk. Impairments in memory were most common in dogs with IE, but progression of impairments was not observed compared to controls. A significant interaction between epilepsy and age was identified, with IE dogs exhibiting a higher risk of CCD at a young age, while control dogs followed the expected pattern of low-risk throughout middle age, with risk increasing exponentially in geriatric years. Within the IE sub-population, dogs with a history of cluster seizures and high seizure frequency had higher CCDR scores. The age of onset, nature and progression of cognitive impairment in the current IE dogs appear divergent from those classically seen in CCD. Longitudinal monitoring of cognitive function from seizure onset is required to further characterise these impairments.

  2. Kidney Damage in Hemorrhagic Vasculitis Occurring in Childhood and Adulthood

    Directory of Open Access Journals (Sweden)

    O.V. Syniachenko

    2016-10-01

    Full Text Available Introduction. Nephropathy is diagnosed in 30–60 % of patients with hemorrhagic vasculitis (HV (Schönlein Henoch puprupa and occurred in each fourth of them in the onset of the disease and with the same incidence at first recurrence of the patho­logical process. In recent years, the relative and absolute number of patients with this form of glomerular disease significantly increased. According to the results of the kidney biopsy in children, Henoch glomerulonephritis (HGN is the most common variant of the secondary immunoglobulin (Ig A nephritis. The nature of the clinical course and morphological manifestations of the HGN in patients with HV, which began in childhood and adulthood, remains unexplored. This was the purpose and objectives of this study. Materials and methods. The study included 174 patients with HV (83 % of men and 47 % of women. In 92 cases, vasculitis debuted in children (on average in 12 years, and in 82 — in the adults (on average in 25 years. I, II and III degree of activity of pathological process are set at a ratio of 1 : 2 : 2. Seropositivity for high levels of IgA occurred in 40 % of cases, by the presence of rheumatoid factor — in 27 %. At the time of the survey, cutaneous syndrome was diagnosed in 68 % of patients in the form of urticarial, hemorrhagic, papule-nodular, papule-necro­tic, pustular-ulcerative, necrotic-ulcerative, nodose-ulcerative and polymorphic forms, and articular syndrome — in 48 %. In 24 cases, kidney biopsy was performed. Results. Renal disease was revealed in 71 % of patients with HV, while on the background of nephropathy the integral index of the severity of extrarenal patho­logy was significantly higher. According to the characteristics of the articular syndrome, patients with nephropathy and without it differed little among themselves. The severity of muscle syndrome has the impact on the development of the HV. In turn, renal pathology significantly influenced the development

  3. The word concreteness effect occurs for positive, but not negative, emotion words in immediate serial recall.

    Science.gov (United States)

    Tse, Chi-Shing; Altarriba, Jeanette

    2009-02-01

    The present study examined the roles of word concreteness and word valence in the immediate serial recall task. Emotion words (e.g. happy) were used to investigate these effects. Participants completed study-test trials with seven-item study lists consisting of positive or negative words with either high or low concreteness (Experiments 1 and 2) and neutral (i.e. non-emotion) words with either high or low concreteness (Experiment 2). For neutral words, the typical word concreteness effect (concrete words are better recalled than abstract words) was replicated. For emotion words, the effect occurred for positive words, but not for negative words. While the word concreteness effect was stronger for neutral words than for negative words, it was not different for the neutral words and the positive words. We conclude that both word valence and word concreteness simultaneously contribute to the item and order retention of emotion words and discuss how Hulme et al.'s (1997) item redintegration account can be modified to explain these findings.

  4. Simultaneous bilateral-knee MR imaging.

    Science.gov (United States)

    Kogan, Feliks; Levine, Evan; Chaudhari, Akshay S; Monu, Uchechukwuka D; Epperson, Kevin; Oei, Edwin H G; Gold, Garry E; Hargreaves, Brian A

    2017-12-17

    To demonstrate and evaluate the scan time and quantitative accuracy of simultaneous bilateral-knee imaging compared with single-knee acquisitions. Hardware modifications and safety testing was performed to enable MR imaging with two 16-channel flexible coil arrays. Noise covariance and sensitivity-encoding g-factor maps for the dual-coil-array configuration were computed to evaluate coil cross-talk and noise amplification. Ten healthy volunteers were imaged on a 3T MRI scanner with both dual-coil-array bilateral-knee and single-coil-array single-knee configurations. Two experienced musculoskeletal radiologists compared the relative image quality between blinded image pairs acquired with each configuration. Differences in T 2 relaxation time measurements between dual-coil-array and single-coil-array acquisitions were compared with the standard repeatability of single-coil-array measurements using a Bland-Altman analysis. The mean g-factors for the dual-coil-array configuration were low for accelerations up to 6 in the right-left direction, and minimal cross-talk was observed between the two coil arrays. Image quality ratings of various joint tissues showed no difference in 89% (95% confidence interval: 85-93%) of rated image pairs, with only small differences ("slightly better" or "slightly worse") in image quality observed. The T 2 relaxation time measurements between the dual-coil-array configuration and the single-coil configuration showed similar limits of agreement and concordance correlation coefficients (limits of agreement: -0.93 to 1.99 ms; CCC: 0.97 (95% confidence interval: 0.96-0.98)), to the repeatability of single-coil-array measurements (limits of agreement: -2.07 to 1.96 ms; CCC: 0.97 (95% confidence interval: 0.95-0.98)). A bilateral coil-array setup can image both knees simultaneously in similar scan times as conventional unilateral knee scans, with comparable image quality and quantitative accuracy. This has the potential to improve the value of

  5. Eyewitness confidence in simultaneous and sequential lineups: a criterion shift account for sequential mistaken identification overconfidence.

    Science.gov (United States)

    Dobolyi, David G; Dodson, Chad S

    2013-12-01

    Confidence judgments for eyewitness identifications play an integral role in determining guilt during legal proceedings. Past research has shown that confidence in positive identifications is strongly associated with accuracy. Using a standard lineup recognition paradigm, we investigated accuracy using signal detection and ROC analyses, along with the tendency to choose a face with both simultaneous and sequential lineups. We replicated past findings of reduced rates of choosing with sequential as compared to simultaneous lineups, but notably found an accuracy advantage in favor of simultaneous lineups. Moreover, our analysis of the confidence-accuracy relationship revealed two key findings. First, we observed a sequential mistaken identification overconfidence effect: despite an overall reduction in false alarms, confidence for false alarms that did occur was higher with sequential lineups than with simultaneous lineups, with no differences in confidence for correct identifications. This sequential mistaken identification overconfidence effect is an expected byproduct of the use of a more conservative identification criterion with sequential than with simultaneous lineups. Second, we found a steady drop in confidence for mistaken identifications (i.e., foil identifications and false alarms) from the first to the last face in sequential lineups, whereas confidence in and accuracy of correct identifications remained relatively stable. Overall, we observed that sequential lineups are both less accurate and produce higher confidence false identifications than do simultaneous lineups. Given the increasing prominence of sequential lineups in our legal system, our data argue for increased scrutiny and possibly a wholesale reevaluation of this lineup format. PsycINFO Database Record (c) 2013 APA, all rights reserved.

  6. Io - One of at Least Four Simultaneous Erupting Volcanic Eruptions

    Science.gov (United States)

    1979-01-01

    This photo of an active volcanic eruption on Jupiter's satellite Io was taken 1 hour, 52 minutes after the accompanying picture, late in the evening of March 4, 1979, Pacific time. On the limb of the satellite can be seen one of at least four simultaneous volcanic eruptions -- the first such activity ever observed on another celestial body. Seen against the limb are plume-like structures rising more than 60 miles (100 kilometers) above the surface. Several eruptions have been identified with volcanic structures on the surface of Io, which have also been identified by Voyager 1's infrared instrument as being abnormally hot -- several hundred degrees warmer than surrounding terrain. The fact that several eruptions appear to be occurring at the same time suggests that Io has the most active surface in the solar system and that volcanism is going on there essentially continuously. Another characteristic of the observed volcanism is that it appears to be extremely explosive, with velocities more than 2,000 miles an hour (at least 1 kilometer per second). That is more violent than terrestrial volcanoes like Etna, Vesuvius or Krakatoa.

  7. A phoswich detector for simultaneous alpha–gamma spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Moghadam, S. Rajabi [Department of Radiation Application, Shahid Beheshti University G.C., Tehran (Iran, Islamic Republic of); Feghhi, S.A.H., E-mail: A_feghhi@sbu.ac.ir [Department of Radiation Application, Shahid Beheshti University G.C., Tehran (Iran, Islamic Republic of); Safari, M.J. [Amirkabir University of Technology, Department of Energy Engineering and Physics, Tehran (Iran, Islamic Republic of)

    2015-11-01

    Phoswich detectors are of value for radiation spectroscopy, especially in cases where a low-cost solution for a mixed radiation field is desired. Meanwhile, simultaneous spectroscopy of alpha particles and gamma-rays has many applications in quantification and distinguishing the alpha-emitting radionuclides which usually occur in the analysis of environmental solid samples. Here, we have developed a system for detection of radioactive actinides (e.g., {sup 241}Am) based on the alpha–gamma coincidence technique. The underlying concept, is to assemble two appropriately selected scintillators (i.e., a fast and a slow one) together with a discriminating unit for analysis of their data. Detailed Monte Carlo simulation procedure has been developed using the GEANT4 toolkit to design and find enough knowledge about the response of the system in the studied radiation field. Various comparisons were made between experimental and simulation data which showed appropriate agreement between them. The calibration was performed and the MDA was estimated as 60 mBq for the phoswich system.

  8. Simultaneous UV-Visible Absorption and Raman Spectroelectrochemistry.

    Science.gov (United States)

    Ibañez, David; Garoz-Ruiz, Jesus; Heras, Aranzazu; Colina, Alvaro

    2016-08-16

    The development of a new device based on the use of UV-vis bare optical fibers in a long optical path length configuration and the measurement of the Raman response in normal arrangement allows us to perform UV-vis and Raman spectroelectrochemistry simultaneously in a single experiment. To the best of our knowledge, this is the first time that a spectroelectrochemistry device is able to record both spectroscopic responses at the same time, which further expands the versatility of spectroelectrochemistry techniques and enables us to obtain much more high-quality information in a single experiment. Three different electrochemical systems, such as ferrocyanide, dopamine, and 3,4-ethylenedioxythiophene, have been studied to validate the cell and to demonstrate the performance of the device. Processes that take place in solution can be properly distinguished from processes that occur on the electrode surface during the electrochemical experiment, providing a whole picture of the reactions taking place at the electrode/solution interface. Therefore, this device allows us to study a larger number of complex electrochemical processes from different points of view taking into account not only the UV-vis spectral changes in the solution adjacent to the electrode but also the Raman signal at any location. Furthermore, complementary information, which could not be unambiguously extracted without considering together the two spectroscopic signals and the electrochemical response, is obtained in a novel way.

  9. Simultaneous Rotational and Axial Flow of Nonlinear Fluids

    Science.gov (United States)

    Ashrafi, Nariman; Yektapour, Mehdi; Shafahi, Mehdi

    2017-11-01

    An axial flow is introduced to the rotational flow of pseudoplastic fluids in the gap between concentric cylinders. The outer cylinder is fixed while the inner one has simultaneous and independent rotational and translational motions. The fluid follows the Carreau-Bird model and mixed boundary conditions are imposed. The four-dimensional low-order equations resulted from Galerkin projection of the conservation of mass and momentum equations, includes highly non-linear terms in the velocity components. Without axial flow, stability of the base radial flow is lost to the vortex structure at a lower critical Taylor number, with increase of the fluid pseudoplasticity. The vortices imply onset of a supercritical bifurcation which occurs in the rotational flow of linear fluids as well. In contrast to the Newtonian case, pseudoplastic Taylor vortices lose their stability at a second critical Taylor number is reached a second critical number that corresponds to the onset of a Hopf bifurcation. The axial flow, caused by the translational motion of the inner cylinder advance each critical point on the bifurcation diagram. The flow field and viscosity maps are provided for major stability regions.

  10. Simultaneous adrenal pheochromocytoma and carotid body paraganglioma in a woman

    Energy Technology Data Exchange (ETDEWEB)

    Han, Eun Ji; Lee, Sang Hoon; Song, In Uk; Chung, Yong An; Maeng, Lee So [The Catholic Univ. of Korea, Incheon (Korea, Republic of)

    2012-03-15

    Simultaneous occurrence of carotid body tumor and pheochromocytoma is rare. Most pheochromocytomas have grown on adrenal medulla, but some of the pheochromocytoma patients have multifocal paragangliomas arising from extraaderenal tissues. Pheochromocytomas and paragangliomas occur as sporadic tumors or they can be associated with several hereditary syndromes such as (1) multiple endocrine neoplasia type 2 (MEN 2), (2) Von Hippel Lindau disease (VHL) and (3) neurofibromatosis type 1 as an unusual genetic cause of pheochromocytomas. Genetic testing is recommended for patients with an apparently sporadic pheochromocytoma under the age of 20 years with a family history or features suggestive of hereditary pheochromocytoma or for patients with sympathetic paragangliomas. For individuals who do not meet these criteria, genetic testing is optional. Discovery of pheochromocytoma or paraganglioma in a patient should lead to a careful search to rule out multifocal lesions and/or hereditary syndromes. The diagnosis of pheochromocytoma and paraganglioma is made by biochemical testing, and imaging is done to localize the tumor for surgical planning. F 18 FDG PET has proved to be an effective tool in the localization of pheochromocytomas and paragangliomas.

  11. First height comparison of noctilucent clouds and simultaneous PMSE

    Science.gov (United States)

    Waelchli, Urs; Stegman, Jacek; Witt, Georg; Cho, John Y. N.; Miller, Clark A.; Kelley, Michael C.; Swartz, Wesley E.

    1993-01-01

    On the night of August 9-10, 1991, two rocket payloads were launched into simultaneously occurring noctilucent clouds (NLC) and polar mesospheric summer echoes (PMSE) above Esrange, a third rocket payload was launched into a NLC where a PMSE was detected 5 minutes later above Esrange, in Sweden as part of the NLC-91 campaign. An aim of this experiment was to compare the vertical structures and locations of the NLC and PMSE events. To this end, in-situ optical photometers and particle impact sensors were used to measure the altitude and vertical structure of the NLC layer, while the Cornell University portable radar interferometer (CUPRI) was used to probe the PMSE. Although this comparison is complicated by the horizontal separations between the in-situ measurements and the radar volume, and low electron densities which reduced the overall radar reflectivity, we conclude that the PMSE layer in the CUPRI radar volume remained above the NLC layer detected by the in-situ instruments by 300 to 2000 m throughout the experiment. We interpret this result as supporting the view that PMSE are more likely to result from the presence of aerosols smaller than the ones optically detectable as NLCs.

  12. Changes in the body posture of women occurring with age.

    Science.gov (United States)

    Drzał-Grabiec, Justyna; Snela, Sławomir; Rykała, Justyna; Podgórska, Justyna; Banaś, Agnieszka

    2013-10-12

    A current topic in the field of geriatrics still needing a great deal of study is the changes in body posture occurring with age. Symptoms of these changes can be observed starting between the ages of 40-50 years with a slow progression that increases after 60 years of age. The aims of this study were to evaluate parameters characterizing the posture of women over the age of 60 years compared with a control group and to determine the dynamics of body posture changes in the following decades. The study included 260 randomly selected women. The study group consisted of 130 women between the ages of 60-90 years (Older Women). The control group (Younger Women) consisted of 130 women between the ages of 20-25 years (posture stabilization period). The photogrammetric method was used to evaluate body posture using the phenomenon of the projection chamber. The study was conducted according to generally accepted principles. In the analysis of parameters characterizing individual slope curves, results were varied among different age groups. The lumbar spine slope did not show significant differences between different age groups (p = 0.6952), while statistically significant differences (p = 0.0000) were found in the thoracic-lumbar spine slope (p = 0.0033) and upper thoracic spine slope. Body angle was shown to increase with age (p = 0.0000). Thoracic kyphosis depth significantly deepened with age (p = 0.0002), however, the thoracic kyphosis angle decreased with age (p = 0.0000). An increase in asymmetries was noticed, provided by a significantly higher angle of the shoulder line (p = 0.0199) and the difference in height of the lower shoulder blade angle (p = 0.0007) measurements in the group of older women. Changes in the parameters describing body posture throughout consecutive decades were observed. Therapy for women over the age of 60 years should involve strengthening of the erector spinae muscles and controlling body posture with the aim of reducing trunk inclination

  13. Naturally Occurring Radioactive Material (NORM) in oil and gas industry

    International Nuclear Information System (INIS)

    Algalhoud, K. A.; AL-Fawaris, B. H.

    2008-01-01

    Oil and gas industry in the Great Jamahiriya is one of those industries that were accompanied with generation of some solid and liquid waste, which associated with risks that might lead to harmful effects to the man and the environment. Among those risks the continuous increase of radioactivity levels above natural radioactive background around operating oil fields, due to accumulation of solid and liquid radioactive scales and sludge as well as contaminated produced water that contain some naturally occurring radioactive materials ( NORM/TE-NORM). Emergence of NORM/TE-NORM in studied area noticed when the natural background radioactivity levels increased around some oil fields during end of 1998, For this study, six field trips and a radiation surveys were conducted within selected oil fields that managed and owned by six operating companies under NOC, in order to determine the effective radiation dose in contrast with dose limits set by International Counsel of Radiation Protection(ICRP),and International Atomic Energy Agency(IAEA) Additionally solid samples in a form of scales and liquid samples were also taken for further investigation and laboratory analysis. Results were tabulated and discussed within the text .However to be more specific results pointed out to the fact that existence of NORM/TE-NORM as 226 Ra, 228 Ra, within some scale samples from surface equipment in some oil and gas fields in Jamahiriya were significant. As a result of that, the workers might receive moderate radiation dose less than the limits set by ICRP,IAEA, and other parts of the world producing oil and gas. Results predicted that within the investigated oil fields if workers receive proper training about handling of NORM/TE-NORM and follow the operating procedure of clean ups, work over and maintenance plane carefully, their committed exposure from NORM/TE-NORM will be less than the set limits by ICRP and IAEA. In a trend to estimate internal radiation dose as a result of possible

  14. Committed effective dose from naturally occuring radionuclides in shellfish

    Science.gov (United States)

    Khandaker, Mayeen Uddin; Wahib, Norfadira Binti; Amin, Yusoff Mohd.; Bradley, D. A.

    2013-07-01

    Recognizing their importance in the average Malaysian daily diet, the radioactivity concentrations in mollusc- and crustacean-based food have been determined for key naturally occuring radionuclides. Fresh samples collected from various maritime locations around peninsular Malaysia have been processed using standard procedures; the radionuclide concentrations being determined using an HPGe γ-ray spectrometer. For molluscs, assuming secular equilibrium, the range of activities of 238U (226Ra), 232Th (228Ra) and 40K were found to be 3.28±0.35 to 5.34±0.52, 1.20±0.21 to 2.44±0.21 and 118±6 to 281±14 Bq kg-1 dry weight, respectively. The respective values for crustaceans were 3.02±0.57 to 4.70±0.52, 1.38±0.21 to 2.40±0.35 and 216±11 to 316±15 Bq kg-1. The estimated average daily intake of radioactivity from consumption of molluscs are 0.37 Bq kg-1 for 238U (226Ra), 0.16 Bq kg-1 for 232Th (228Ra) and 18 Bq kg-1 for 40K; the respective daily intake values from crustaceans are 0.36 Bq kg-1, 0.16 Bq kg-1 and 23 Bq kg-1. Associated annual committed effective doses from molluscs are estimated to be in the range 21.3 to 34.7 μSv for 226Ra, 19.3 to 39.1 μSv for 228Ra and 17.0 to 40.4 μSv for 40K. For crustaceans, the respective dose ranges are 19.6 to 30.5 μSv, 22.0 to 38.4 μSv and 31.1 to 45.5 μSv, being some several times world average values.

  15. Simultaneous Mass Determination for Gravitationally Coupled Asteroids

    Energy Technology Data Exchange (ETDEWEB)

    Baer, James [Private address, 3210 Apache Road, Pittsburgh, PA 15241 (United States); Chesley, Steven R., E-mail: jimbaer1@earthlink.net [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States)

    2017-08-01

    The conventional least-squares asteroid mass determination algorithm allows us to solve for the mass of a large subject asteroid that is perturbing the trajectory of a smaller test asteroid. However, this algorithm is necessarily a first approximation, ignoring the possibility that the subject asteroid may itself be perturbed by the test asteroid, or that the encounter’s precise geometry may be entangled with encounters involving other asteroids. After reviewing the conventional algorithm, we use it to calculate the masses of 30 main-belt asteroids. Compared to our previous results, we find new mass estimates for eight asteroids (11 Parthenope, 27 Euterpe, 51 Neimausa, 76 Freia, 121 Hermione, 324 Bamberga, 476 Hedwig, and 532 Herculina) and significantly more precise estimates for six others (2 Pallas, 3 Juno, 4 Vesta, 9 Metis, 16 Psyche, and 88 Thisbe). However, we also find that the conventional algorithm yields questionable results in several gravitationally coupled cases. To address such cases, we describe a new algorithm that allows the epoch state vectors of the subject asteroids to be included as solve-for parameters, allowing for the simultaneous solution of the masses and epoch state vectors of multiple subject and test asteroids. We then apply this algorithm to the same 30 main-belt asteroids and conclude that mass determinations resulting from current and future high-precision astrometric sources (such as Gaia ) should conduct a thorough search for possible gravitational couplings and account for their effects.

  16. Simultaneous bilateral isolated greater trochanter fracture

    Directory of Open Access Journals (Sweden)

    Maruti Kambali

    2013-01-01

    Full Text Available A 48-year-old woman sustained simultaneous isolated bilateral greater trochanteric fracture, following a road traffic accident. The patient presented to us 1 month after the injury. She presented with complaints of pain in the left hip and inability to walk. Roentgenograms revealed displaced comminuted bilateral greater trochanter fractures. The fracture of the left greater trochanter was reduced and fixed internally using the tension band wiring technique. The greater trochanter fracture on the right side was asymptomatic and was managed conservatively. The patient regained full range of motion and use of her hips after a postoperative follow-up of 6 months. Isolated fractures of the greater trochanter are unusual injuries. Because of their relative rarity and the unsettled controversy regarding their etiology and pathogenesis, several methods of treatment have been advocated. Furthermore, the reports of this particular type of injury are not plentiful and the average textbook coverage afforded to this entity is limited. In our study we discuss the mechanism of injury and the various treatment options available.

  17. Simultaneous perturbation stochastic approximation for tidal models

    KAUST Repository

    Altaf, M.U.

    2011-05-12

    The Dutch continental shelf model (DCSM) is a shallow sea model of entire continental shelf which is used operationally in the Netherlands to forecast the storm surges in the North Sea. The forecasts are necessary to support the decision of the timely closure of the moveable storm surge barriers to protect the land. In this study, an automated model calibration method, simultaneous perturbation stochastic approximation (SPSA) is implemented for tidal calibration of the DCSM. The method uses objective function evaluations to obtain the gradient approximations. The gradient approximation for the central difference method uses only two objective function evaluation independent of the number of parameters being optimized. The calibration parameter in this study is the model bathymetry. A number of calibration experiments is performed. The effectiveness of the algorithm is evaluated in terms of the accuracy of the final results as well as the computational costs required to produce these results. In doing so, comparison is made with a traditional steepest descent method and also with a newly developed proper orthogonal decompositionbased calibration method. The main findings are: (1) The SPSA method gives comparable results to steepest descent method with little computational cost. (2) The SPSA method with little computational cost can be used to estimate large number of parameters.

  18. Simultaneous brightness contrast of foraging Papilio butterflies

    Science.gov (United States)

    Kinoshita, Michiyo; Takahashi, Yuki; Arikawa, Kentaro

    2012-01-01

    This study focuses on the sense of brightness in the foraging Japanese yellow swallowtail butterfly, Papilio xuthus. We presented two red discs of different intensity on a grey background to butterflies, and trained them to select one of the discs. They were successfully trained to select either a high intensity or a low intensity disc. The trained butterflies were tested on their ability to perceive brightness in two different protocols: (i) two orange discs of different intensity presented on the same intensity grey background and (ii) two orange discs of the same intensity separately presented on a grey background that was either higher or lower in intensity than the training background. The butterflies trained to high intensity red selected the orange disc of high intensity in protocol 1, and the disc on the background of low intensity grey in protocol 2. We obtained similar results in another set of experiments with purple discs instead of orange discs. The choices of the butterflies trained to low intensity red were opposite to those just described. Taken together, we conclude that Papilio has the ability to learn brightness and darkness of targets independent of colour, and that they have the so-called simultaneous brightness contrast. PMID:22179808

  19. Dyspnea and Pain Frequently Co-occur among Medicare Managed Care Recipients

    Science.gov (United States)

    Clark, Nathan; Fan, Vincent S.; Slatore, Christopher G.; Locke, Emily; Whitson, Heather E.; Nici, Linda

    2014-01-01

    Rationale: Experimental and neuroimaging studies have suggested strong associations between dyspnea and pain. The co-occurrence of these symptoms has not been examined in community samples. Objectives: We sought to ascertain the co-occurrence of pain and dyspnea by self-report in a large cohort of Medicare recipients. Methods: We analyzed data from 266,000 Medicare Managed Care recipients surveyed in 2010 and 2012. Dyspnea was defined by aggregating three questions about shortness of breath (at rest, while walking one block, and while climbing stairs). Pain was measured by four questions about pain interference, chest pain, back pain, and arthritis pain. All measures were dichotomized as high or low/none. We calculated the co-occurrence of pain and dyspnea at baseline, and generated logistic regression models to find the adjusted relative risk (RR) of their co-occurrence, adjusting for patient-level factors and three potential medical causes of dyspnea (chronic obstructive pulmonary disease/emphysema/asthma, congestive heart failure, and obesity). We modeled the simultaneous development and the simultaneous resolution of dyspnea and pain between baseline and 2 years. Measurements and Main Results: Participants with dyspnea had considerably higher prevalence of pain than those without (64 vs. 18%). In fully adjusted models, participants with any of the types of pain were substantially more likely to report dyspnea than those without these types of pain (high pain interference: relative risk [RR], 1.99; 95% confidence interval [CI], 1.92–2.07; chest pain: RR, 2.11; 95% CI, 2.04–2.18; back pain: RR, 1.76; 95% CI, 1.71–1.82; and arthritis pain: RR, 1.49; 95% CI, 1.44–1.54). The relative risks of dyspnea developing or resolving at 2 years were greatly increased (RRs of 1.5 – 4) if pain also developed or resolved. Conclusions: Pain and dyspnea commonly occurred, developed, and resolved together. Most older adults with dyspnea also reported pain. Medical

  20. A robust multilevel simultaneous eigenvalue solver

    Science.gov (United States)

    Costiner, Sorin; Taasan, Shlomo

    1993-01-01

    Multilevel (ML) algorithms for eigenvalue problems are often faced with several types of difficulties such as: the mixing of approximated eigenvectors by the solution process, the approximation of incomplete clusters of eigenvectors, the poor representation of solution on coarse levels, and the existence of close or equal eigenvalues. Algorithms that do not treat appropriately these difficulties usually fail, or their performance degrades when facing them. These issues motivated the development of a robust adaptive ML algorithm which treats these difficulties, for the calculation of a few eigenvectors and their corresponding eigenvalues. The main techniques used in the new algorithm include: the adaptive completion and separation of the relevant clusters on different levels, the simultaneous treatment of solutions within each cluster, and the robustness tests which monitor the algorithm's efficiency and convergence. The eigenvectors' separation efficiency is based on a new ML projection technique generalizing the Rayleigh Ritz projection, combined with a technique, the backrotations. These separation techniques, when combined with an FMG formulation, in many cases lead to algorithms of O(qN) complexity, for q eigenvectors of size N on the finest level. Previously developed ML algorithms are less focused on the mentioned difficulties. Moreover, algorithms which employ fine level separation techniques are of O(q(sub 2)N) complexity and usually do not overcome all these difficulties. Computational examples are presented where Schrodinger type eigenvalue problems in 2-D and 3-D, having equal and closely clustered eigenvalues, are solved with the efficiency of the Poisson multigrid solver. A second order approximation is obtained in O(qN) work, where the total computational work is equivalent to only a few fine level relaxations per eigenvector.

  1. Simultaneous dual pathology in lymph node

    Directory of Open Access Journals (Sweden)

    Prakas Kumar Mandal

    2014-05-01

    Full Text Available [Abstract] Tubercuous lymphadenitis and Non Hodgkins’ Lymphoma are common in India. As both diseases can occur in elderly persons there is a definite chance of co-existence of both diseases; but that coexistence has not been reported. Here we present a unique case in an elderly woman who had synchronous double pathology of tuberculosis (TB and Diffuse Large B cell Lymphoma (DLBCL of the lymph nodes.     Key words:- lymph nodes, tuberculosis (TB, Diffuse Large B cell Lymphoma (DLBCL.

  2. Simultaneous priming along multiple feature dimensions in a visual search task.

    Science.gov (United States)

    Kristjánsson, Arni

    2006-08-01

    What we have recently seen generally has a large effect on how we consequently perceive our visual environment. Such priming effects play a surprisingly large role in visual search tasks, for example. It is unclear, however, whether different features of an object show independent but simultaneous priming. For example, if the color and orientation of a target item are the same as on a previous trial, is performance better than if only one of those features is repeated? In other words this paper presents an attempt at assessing the capacity of priming for different feature dimensions. Observers searched for a three featured object (a gabor patch that was either redscale or greenscale, oriented either to the left or right of vertical and of high or low spatial frequency) among distractors with different values along these feature dimensions. Which feature was the target defining feature; which was the response defining feature and which was the irrelevant feature, was varied between the different experiments. Task relevant features (target defining, or response defining) always resulted in priming effects, while when spatial frequency or orientation were task irrelevant neither resulted in priming, but color always did, even when task irrelevant. Further experiments showed that priming from spatial frequency and orientation could occur when they were task irrelevant but only when the other feature of the two was kept constant across all display items. The results show that simultaneous priming for different features can occur simultaneously, but also that task relevance has a strong modulatory effect on the priming.

  3. Coexistent lymphoma with tuberculosis and Kaposi's sarcoma with tuberculosis occurring in lymph node in patients with AIDS: a report of two cases.

    Science.gov (United States)

    Lanjewar, D N; Lanjewar, Sonali D; Chavan, Gajanan

    2010-01-01

    Although there have been a few reports of simultaneous infections and neoplasm in patients with acquired immune deficiency syndrome, no reports of coexistent lymphoma with tuberculosis and Kaposi's sarcoma with tuberculosis occurring in the same lymph node have been described. In this article, we describe coexistent lymphoma with tuberculosis in one case and Kaposi's sarcoma with tuberculosis in another case of human immune deficiency virus-infected individuals.

  4. Simultaneous spreading and evaporation: recent developments.

    Science.gov (United States)

    Semenov, Sergey; Trybala, Anna; Rubio, Ramon G; Kovalchuk, Nina; Starov, Victor; Velarde, Manuel G

    2014-04-01

    The recent progress in theoretical and experimental studies of simultaneous spreading and evaporation of liquid droplets on solid substrates is discussed for pure liquids including nanodroplets, nanosuspensions of inorganic particles (nanofluids) and surfactant solutions. Evaporation of both complete wetting and partial wetting liquids into a nonsaturated vapour atmosphere are considered. However, the main attention is paid to the case of partial wetting when the hysteresis of static contact angle takes place. In the case of complete wetting the spreading/evaporation process proceeds in two stages. A theory was suggested for this case and a good agreement with available experimental data was achieved. In the case of partial wetting the spreading/evaporation of a sessile droplet of pure liquid goes through four subsequent stages: (i) the initial stage, spreading, is relatively short (1-2 min) and therefore evaporation can be neglected during this stage; during the initial stage the contact angle reaches the value of advancing contact angle and the radius of the droplet base reaches its maximum value, (ii) the first stage of evaporation is characterised by the constant value of the radius of the droplet base; the value of the contact angle during the first stage decreases from static advancing to static receding contact angle; (iii) during the second stage of evaporation the contact angle remains constant and equal to its receding value, while the radius of the droplet base decreases; and (iv) at the third stage of evaporation both the contact angle and the radius of the droplet base decrease until the drop completely disappears. It has been shown theoretically and confirmed experimentally that during the first and second stages of evaporation the volume of droplet to power 2/3 decreases linearly with time. The universal dependence of the contact angle during the first stage and of the radius of the droplet base during the second stage on the reduced time has been

  5. Bilateral Simultaneous Nonarteritic Anterior Ischemic Optic Neuropathy after Ingestion of Sildenafil for Erectile Dysfunction

    Directory of Open Access Journals (Sweden)

    Anna Tarantini

    2012-01-01

    Full Text Available Purpose. To describe a patient who developed bilateral, simultaneous nonarteritic anterior ischemic optic neuropathy (NAION after ingestion of Sildenafil citrate (Viagra for erectile dysfunction. Methods. Observational case report. Results. A 60-year-old diabetic man noted sudden decrease of vision in both eyes 16 hours after his third consecutive 50 mg daily Sildenafil ingestion. A diagnosis of bilateral NAION was made and he was treated for three days with methylprednisolone 1 g/d intravenously, followed by oral prednisone 75 mg/d. Final visual acuity was 20/50 right eye (OD and 20/20 left eye (OS. He had preexisting diabetes. Conclusion. This is the first reported case of simultaneous bilateral NAION occurred in a diabetic patient early after Sildenafil intake. Patients with predisposing conditions such as diabetes have to be warned against the use of PDE inhibitors.

  6. Simultaneous multiphoton processes in the interaction of atoms with electromagnetic fields

    International Nuclear Information System (INIS)

    Levine, A.M.; Schreiber, W.M.; Weiszmann, A.N.

    1984-01-01

    It is impossible to obtain an exact description of multiphoton processes in the interaction of electromagnetic fields with atomic systems. Approximate approaches must be used to describe the physically different effects that can occur. One effect is the stepwise absorption/emission of many photons by a N-level system that evolves dynamically in between each absorption/emission. Another effect is described in the theories of Raman processes where the simultaneous absorption/emission of many photons is considered. In this paper, consideration is given to both processes allowing interference between the stepwise and simultaneous absorptions. An approximate Hamiltonian is obtained from the quantum mechanical multipole expansion. An exact solution of an atom-field system subject to this Hamiltonian will be presented. The extension of the method to multiple electromagnetic fields is discussed

  7. SIMULTANEOUS INFECTION WITH DENGUE 1 AND 2 IN A BRAZILIAN PATIENT

    Directory of Open Access Journals (Sweden)

    ROCCO Iray Maria

    1998-01-01

    Full Text Available Dengue outbreaks have occurred in several Brazilian States since 1986 involving serotypes 1 (DEN-1 and 2 (DEN-2. In view of the few cases of double infection documented in the literature, we report here a case of simultaneous infection with DEN-1 and DEN-2 in a patient residing in the municipality of Miranda, State of Mato Grosso do Sul, Western region of Brazil. DEN-1 was introduced in this State in 1989 and DEN-2 in 1996, both of them circulating in some municipalities. This double infection was identified by virus isolation and by indirect immunofluorescence using monoclonal antibodies and confirmed by the polymerase chain reaction (PCR. This is the first documented case of simultaneous infection with serotypes DEN-1 and DEN-2 in Brazil.

  8. Four Beam Generation for Simultaneous Four-Hall Operation at CEBAF

    Energy Technology Data Exchange (ETDEWEB)

    Kazimi, Reza [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Grames, Joseph M. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Hansknecht, John C. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Hofler, Alicia S. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Lahti, George E. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Plawski, Tomasz E. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Poelker, Matt [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Suleiman, RIad S. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Wang, Yan [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2016-05-01

    As part of the CEBAF 12 GeV upgrade at Jefferson Lab, a new experimental hall was added to the existing three halls. To deliver beam to all four halls simultaneous-ly, a new timing pattern for electron bunches is needed at the injector. This pattern change has consequences for the frequency of the lasers at the photogun, beam behavior in the chopping system, beam optics due to space charge, and setup procedures. We have successfully demonstrated this new pattern using the three existing drive lasers. The implementation of the full system will occur when the fourth laser is added and upgrades to the Low Level RF (LLRF) are complete. In this paper we explain the new bunch pattern, the challenges for setting and measuring the pattern such as 180° RF phase ambiguity, addition of the fourth laser to the laser table and LLRF upgrade.

  9. Maximising position resolution for near-simultaneous events with charge division readouts

    CERN Document Server

    Lapington, J S

    2002-01-01

    The maximum count rate of charge division readouts is fundamentally limited by the signal-to-noise ratio (SNR) required from the charge measurement electronics. The traditional charge measurement solution comprises a charge sensitive preamplifier, shaping amplifier and digitizer. The pulse processing time is limited by the shaping time constant required for a given SNR. We present a technique to measure event pulse heights from each readout channel using waveforms captured directly from the preamplifier output. This method uses signal analysis techniques, for example waveform fitting, to measure the charge collected by each readout channel, from several, almost simultaneous events. Given the signal processing requirements, this technique is suitable for applications where near-simultaneous events occur at relatively low-repetition rates. We discuss the signal analysis methods used and measure the achievable SNR ratio. We describe the preliminary experimental set-up, which uses a digital scope for waveform cap...

  10. The unpredictable outcomes of bilateral simultaneous fractures of ...

    African Journals Online (AJOL)

    Bilateral simultaneous fractures of Neck of Femur (NOF) are rare. They result amongst others from trauma, metabolic disease, electro-convulsion and simple falls. We report two cases of 40-year-old and 74-year-old females who presented with bilateral simultaneous fractures of NOF post simple falls. Both patients had ...

  11. Simultaneous growth and yield models for Eucalyptus grandis (Hill ...

    African Journals Online (AJOL)

    Simultaneous stand-level growth and yield models for Eucalyptus grandis in Zimbabwe were developed from Correlated Curve Trend (CCT) and Nelder wheel experiments replicated on five different sites. Nonlinear three-stage least squares method was used to simultaneously fit prediction and projection equations for ...

  12. A desirability functions-based approach for simultaneous ...

    African Journals Online (AJOL)

    simultaneous optimization of quantitative and ordinal response variables. But none of these approaches results in an efficient optimal solution with respect to the desirability values of all the individual response variables. It motivated us to develop a more useful approach for simultaneously optimizing industrial processes ...

  13. students' preference of method of solving simultaneous equations

    African Journals Online (AJOL)

    Ugboduma,Samuel.O.

    More so, they will be reposition in order to solve other mathematical problems involving applications of simultaneous equations methods of solutions. Research questions. The following research questions were asked: i what proportion of SSS2 students showed preference for one type of method of solving simultaneous.

  14. Simultaneous Determination of Famotidine and Flurbiprofen by High ...

    African Journals Online (AJOL)

    Purpose: To develop a selective, sensitive and accurate simultaneous High Performance Liquid. Chromatography (HPLC) method for the analysis of flurbiprofen and famotidine tablet dosage form and excipients. Methods: A simultaneous method for the determination of the two drugs was employed. The assay consisted of ...

  15. Sign Language Comprehension by Autistic Children Following Simultaneous Communication Training.

    Science.gov (United States)

    Dores, Paul A.; Carr, Edward G.

    Six nonverbal, autistic boys (ages 6 to 11) were studied to assess what was learned when signs and spoken words were presented simultaneously. The boys were taught to discriminate among several available objects when given commands consisting of simultaneously signed and spoken object labels. Each of the six children mastered all of the…

  16. Simultaneous Determination of Famotidine and Flurbiprofen by High ...

    African Journals Online (AJOL)

    Purpose: To develop a selective, sensitive and accurate simultaneous High Performance Liquid Chromatography (HPLC) method for the analysis of flurbiprofen and famotidine tablet dosage form and excipients. Methods: A simultaneous method for the determination of the two drugs was employed. The assay consisted of ...

  17. Interaction and coalescence of multiple simultaneous and non-simultaneous blast waves

    Science.gov (United States)

    Qiu, S.; Eliasson, V.

    2016-05-01

    Interaction of multiple blast waves can be used to direct energy toward a target while simultaneously reducing collateral damage away from the target area. In this paper, simulations of multiple point source explosives were performed and the resulting shock interaction and coalescence behavior were explored. Three to ten munitions were placed concentrically around the target, and conditions at the target area were monitored and compared to those obtained using a single munition. For each simulation, the energy summed over all munitions was kept constant, while the radial distances between target and munitions and the munition initiation times were varied. Each munition was modeled as a point source explosion. The resulting blast wave propagation and shock front coalescence were solved using the inviscid Euler equations of gas dynamics on overlapping grids employing a finite difference scheme. Results show that multiple munitions can be beneficial for creating extreme conditions at the intended target area; over 20 times higher peak pressure is obtained for ten simultaneous munitions compared to a single munition. Moreover, peak pressure at a point away from the target area is reduced by more than a factor of three.

  18. Co-infection of an animal with more than one genotype can occur in anthrax.

    Science.gov (United States)

    Beyer, W; Turnbull, P C B

    2013-10-01

    During the routine fingerprinting of outbreak strains of Bacillus anthracis of European and African origin by means of a 31-marker multi-locus variable number of tandem repeats analysis (MLVA), four cultures, two from the Etosha National Park (ENP), Namibia, and two from an outbreak in the Pyrenees in 1997, were found to harbour different genotypes (GTs). To investigate this further, isolates from 10 samples of blood-soaked soil from beneath anthrax carcasses and 18 clinical swabs taken from carcasses in the ENP were examined by a 31-marker MLVA. While only a single GT was found in any one of the 10 soil samples, four of the 18 swabs (22%) yielded different GTs. Two GTs were isolated from each of a zebra and a springbok and three GTs from each of a second zebra and an elephant. These animals had died in a region of the ENP where deaths caused by anthrax regularly occur every year. The results confirm the indications noted previously that co-infection with more than one GT is probably not especially uncommon. The results show that, for the purpose of analysing genotypes involved in an outbreak, it is important to examine more than a single colony from a clinical sample. Multi-locus variable number of tandem repeats analysis (MLVA)-based fingerprinting techniques have been used in many studies worldwide to characterize the occurrence of different genotypes of Bacillus anthracis in outbreaks of wildlife or livestock and to draw conclusions about the source, the possible routes of spread and the temporal and spatial distribution of outbreak strains. Simultaneous isolation of different genotypes from the same host revealed in our study by MLVA highlights the importance of examining more than a single colony from a clinical sample. This conclusion is not specific for MLVA but holds true for every high-resolution method, including full-genome sequencing. © 2013 The Society for Applied Microbiology.

  19. High diversity of the fungal community structure in naturally-occurring Ophiocordyceps sinensis.

    Directory of Open Access Journals (Sweden)

    Yongjie Zhang

    Full Text Available BACKGROUND: Ophiocordyceps sinensis (syn. Cordyceps sinensis, which is a parasite of caterpillars and is endemic to alpine regions on the Tibetan Plateau, is one of the most valuable medicinal fungi in the world. "Natural O. sinensis specimens" harbor various other fungi. Several of these other fungi that have been isolated from natural O. sinensis specimens have similar chemical components and/or pharmaceutical effects as O. sinensis. Nevertheless, the mycobiota of natural O. sinensis specimens has not been investigated in detail. METHODOLOGY/PRINCIPAL FINDINGS: Based on the technique of PCR-single-strand conformation polymorphism (PCR-SSCP, the mycobiota of three different sections (stromata, sclerotia, and mycelial cortices from natural O. sinensis specimens were investigated using both culture-dependent and -independent methods. For the culture-dependent method, 572 fungal strains were isolated, and 92 putative operational taxonomic units (OTUs were identified from 226 sequenced strains with the threshold of 97%. For the culture-independent method, 490 fungal clones were identified from about 3000 clones of ITS fragments from the whole-community DNA; based on PCR-SSCP analyses, 266 of these clones were selected to be sequenced, and 118 putative OTUs were detected. The overwhelming majority of isolates/clones and OTUs were detected from mycelial cortices; only a few were detected from stromata and sclerotia. The most common OTUs detected with both methods belonged to Ascomycota; however, only 13 OTUs were detected simultaneously by both methods. Potential novel lineages were detected by each of the two methods. CONCLUSIONS/SIGNIFICANCE: A great number of fungal species present in the mycobiota of naturally-occurring O. sinensis specimens were detected, and many of them may represent undescribed lineages. That only a few of the same OTUs were detected by both methods indicated that different methods should be used. This study increased our

  20. Cesarean section and hernia repair: simultaneous approach.

    Science.gov (United States)

    Gabriele, Raimondo; Conte, Marco; Izzo, Luciano; Basso, Luigi

    2010-10-01

    Hernias of the abdominal wall occurring during pregnancy are usually treated a few weeks after delivery. The aim of this study was to retrospectively evaluate the clinical outcome of inguinal or umbilical hernioplasty performed at the time of the cesarean section, and to compare the outcome of this group with a control population, who received a cesarean section alone. We reviewed 28 women who developed an inguinal or umbilical hernia during pregnancy from January 1, 2000 to December 31, 2007 and who received a combined cesarean section and hernia repair, and we compared this group with 100 women (controls) who only received a cesarean section. In the group of women who received a combined cesarean section and inguinal or umbilical hernia repair, median age was 23.8 years and hospital stay ranged from 3 to 5 days (versus 3-4 days for cesarean sections alone). The time employed for the combined surgical procedure was of 50 ± 7 min and 70 ± 4 min, respectively, for umbilical and inguinal hernia (versus 37.4 ± 12.6 min for cesarean sections alone). No complication was recorded during the perinatal and follow-up periods, and no recurrences were observed. Our analysis suggests that cesarean section and hernia repair, performed in one session, avoids need for readmission to hospital, is safe, effective, and well accepted. It neither increases the complication rate nor prolongs the hospital stay, with clear advantages for both the patients and the hospital budget. © 2010 The Authors. Journal of Obstetrics and Gynaecology Research © 2010 Japan Society of Obstetrics and Gynecology.

  1. Simultaneous cerebrovascular and cardiovascular responses during presyncope

    Science.gov (United States)

    Bondar, R. L.; Kassam, M. S.; Stein, F.; Dunphy, P. T.; Fortney, S.; Riedesel, M. L.

    1995-01-01

    BACKGROUND AND PURPOSE: Presyncope, characterized by symptoms and signs indicative of imminent syncope, can be aborted in many situations before loss of consciousness occurs. The plasticity of cerebral autoregulation in healthy humans and its behavior during this syncopal prodrome are unclear, although systemic hemodynamic instability has been suggested as a key factor in the precipitation of syncope. Using lower body negative pressure (LBNP) to simulate central hypovolemia, we previously observed falling mean flow velocities (MFVs) with maintained mean arterial blood pressure (MABP). These findings, and recent reports suggesting increased vascular tone within the cerebral vasculature at presyncope, cannot be explained by the classic static cerebral autoregulation curve; neither can they be totally explained by a recent suggestion of a rightward shift in this curve. METHODS: Four male and five female healthy volunteers were exposed to presyncopal LBNP to evaluate their cerebrovascular and cardiovascular responses by use of continuous acquisition of MFV from the right middle cerebral artery with transcranial Doppler sonography, MABP (Finapres), and heart rate (ECG). RESULTS: At presyncope, MFV dropped on average by 27.3 +/- 14% of its baseline value (P < .05), while MABP remained at 2.0 +/- 27% above its baseline level. Estimated cerebrovascular resistance increased during LBNP. The percentage change from baseline to presyncope in MFV and MABP revealed consistent decreases in MFV before MABP. CONCLUSIONS: Increased estimated cerebrovascular resistance, falling MFV, and constant MABP are evidence of an increase in cerebral vascular tone with falling flow, suggesting a downward shift in the cerebral autoregulation curve. Cerebral vessels may have a differential sensitivity to sympathetic drive or more than one type of sympathetic innervation. Future work to induce dynamic changes in MABP during LBNP may help in assessing the plasticity of the cerebral autoregulation

  2. A roving dual-presentation simultaneity-judgment task to estimate the point of subjective simultaneity

    Directory of Open Access Journals (Sweden)

    Kielan eYarrow

    2016-03-01

    Full Text Available The most popular tasks with which to investigate the perception of subjective synchrony are the temporal order judgment (TOJ and the simultaneity judgment (SJ. Here we discuss a complementary approach – a dual-presentation (2x SJ task – and focus on appropriate analysis methods for a theoretically desirable roving design. Two stimulus pairs are presented on each trial and the observer must select the most synchronous. To demonstrate this approach, in Experiment 1 we tested the 2xSJ task alongside TOJ, SJ and simple reaction-time (RT tasks using audiovisual stimuli. We interpret responses from each task using detection-theoretic models, which assume variable arrival times for sensory signals at critical brain structures for timing perception. All tasks provide similar estimates of the point of subjective simultaneity (PSS on average, and PSS estimates from some tasks were correlated on an individual basis. The 2xSJ task produced lower and more stable estimates of model-based (and thus comparable sensory/decision noise than the TOJ. In Experiment 2 we obtained similar results using RT, TOJ, ternary and 2xSJ tasks for all combinations of auditory, visual and tactile stimuli. In Experiment 3 we investigated attentional prior entry, using both TOJs and 2xSJs. We found that estimates of prior-entry magnitude correlated across these tasks. Overall, our study establishes the practicality of the roving dual-presentation SJ task, but also illustrates the additional complexity of the procedure. We consider ways in which this task might complement more traditional procedures, particularly when it is important to estimate both PSS and sensory/decisional noise.

  3. Simultaneous Blind Separation and Recognition of Speech Mixtures Using Two Microphones to Control a Robot Cleaner

    OpenAIRE

    Lee, Heungkyu

    2013-01-01

    This paper proposes a method for the simultaneous separation and recognition of speech mixtures in noisy environments using two-channel based independent vector analysis (IVA) on a home-robot cleaner. The issues to be considered in our target application are speech recognition at a distance and noise removal to cope with a variety of noises, including TV sounds, air conditioners, babble, and so on, that can occur in a house, where people can utter a voice command to control a robot cleaner at...

  4. Simultaneous bilateral tibial tubercle avulsion fracture in a male teenager: case report and literature review.

    Science.gov (United States)

    Nicolini, Alexandre P; Carvalho, Rogerio T; Ferretti, Mario; Cohen, Moises

    2018-01-01

    Tibial tuberosity avulsion fractures are injuries accounting for less than 3% of all epiphyseal and 1% of all physeal injuries in adolescents. Bilateral injuries are very rare, with only 19 cases described in the literature. These types of fractures occur commonly in male teenagers during sport activities and are often associated with other orthopaedic disorders. We report the case of a male teenager with simultaneous bilateral tibial tubercle fractures, describe the evolution and treatment of this injury and review the literature on this subject. Case report.

  5. Simultaneous thoracoabdominal aortic aneurysm repair and coronary artery bypass grafting through median sternotomy.

    Science.gov (United States)

    Furutachi, Akira; Rikitake, Kazuhisa; Ikeda, Kazuyuki; Nogami, Eijiro; Takaki, Jun

    2014-09-01

    Patients with thoracoabdominal aortic aneurysms (TAAA) often have severe ischemic heart disease. The determination of which condition to treat first is based on disease severity, but in some cases the conditions are equally severe. A 78-year-old woman received a diagnosis of a 59-mm TAAA and coronary artery stenosis. We performed simultaneous TAAA repair, using the patched aortoplasty method, and coronary artery bypass grafting (CABG) through a median sternotomy. No perioperative complications occurred, the patient was discharged in stable condition, and early follow-up visits were uneventful. Copyright © 2014 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  6. Right retrograde brachial cerebral angiography with simultaneous compression of the left carotid artery

    International Nuclear Information System (INIS)

    Ericson, K.; Mosskin, M.

    1981-01-01

    Right retrograde brachial angiography with simultaneous compression of the left common carotid artery was performed in 12 patients, invariably resulting in filling of the right vertebral and the basilar artery. In all but one patient, the right carotid artery and its branches were also filled. Retrograde filling of the left internal carotid artery occurred in 8 patients. Furthermore, retrograde filling of the intracranial part of the left vertebral artery was obtained in 5 of 12 patients. A complete four-vessel cranial angiography was thus obtained in one third of the patients. The method may be considered as a safe and valuable adjunct to other angiographic techniques. (Auth.)

  7. Simultaneous inference for model averaging of derived parameters

    DEFF Research Database (Denmark)

    Jensen, Signe Marie; Ritz, Christian

    2015-01-01

    Model averaging is a useful approach for capturing uncertainty due to model selection. Currently, this uncertainty is often quantified by means of approximations that do not easily extend to simultaneous inference. Moreover, in practice there is a need for both model averaging and simultaneous...... inference for derived parameters calculated in an after-fitting step. We propose a method for obtaining asymptotically correct standard errors for one or several model-averaged estimates of derived parameters and for obtaining simultaneous confidence intervals that asymptotically control the family...

  8. Spatial Frequency Shifts From Counterphase Flicker and From Simultaneous Contrast.

    Science.gov (United States)

    Kaneko, Sae; Anstis, Stuart

    2017-01-01

    In simultaneous contrast of spatial frequency (SF), a test grating surrounded by a coarser inducing grating looks apparently finer. We combined this effect with another visual illusion; the fact that flickering the inducing grating raises its apparent SF. We found that the inducer's apparent , not physical spatial frequency, drove the simultaneous contrast that it induced into a test grating. Thus, when the inducer was made to flicker, its SF appeared to be higher and consequently, the test's SF appeared lower than before. This suggests that simultaneous contrast of spatial frequency exists further downstream than the flicker-induced increase in perceived SF.

  9. Mechano-optical modulator based on a rotating optical flat applied to simultaneous holographic multiplexing of gratings.

    Science.gov (United States)

    Matrisch, Jan; Altmeyer, Stefan

    2018-01-10

    Simultaneous holographic multiplexing methods are used to store multiple holograms concurrently into one holographic volume. Compared to serial exposure, one advantage is the higher processing speed. Additionally, for parallel exposure the different gratings develop in a linear relation to one another, although the developing process itself is nonlinear caused by the holographic photopolymer. A mechano-optical modulator using a rotating optical flat is introduced to enable economic single-shot exposure of centimeter to decimeter-sized holograms utilizing only one laser. The modulator specifically suppresses undesired interference, which occurs with this type of simultaneous exposure. A device concept of the modulator is presented. The application to simultaneous holographic multiplexing is theoretically discussed and experimentally demonstrated. The experimental results are compared to simulations and are evaluated. The functionality and practicability are proven, giving rise to a new design concept and a wider range of applications.

  10. Multiwavelength Raman-fiber-laser-based long-distance remote sensor for simultaneous measurement of strain and temperature.

    Science.gov (United States)

    Han, Young-Geun; Tran, T V A; Kim, Sang-Hyuck; Lee, Sang Bae

    2005-06-01

    We propose a simple and flexible multiwavelength Raman-fiber-laser-based long-distance remote-sensing scheme for simultaneous measurement of strain and temperature by use of fiber Bragg gratings. By combining two uniform fiber Bragg gratings with a tunable chirped fiber grating, we readily achieve simultaneous two-channel sensing probes with a high extinction ratio of more than approximately 50 dB over a 50-km distance. When strain and temperature are applied, lasing wavelength separation and shift occur, respectively, since the two uniform fiber Bragg gratings have identical material composition and different cladding diameters. This allows simultaneous measurement of strain and temperature for long-distance sensing applications of more than 50 km.

  11. Thermoregulatory Behavior Simultaneously Promotes and Forestalls Evolution in a Tropical Lizard.

    Science.gov (United States)

    Muñoz, Martha M; Losos, Jonathan B

    2018-01-01

    The role of behavior in evolution has long been discussed, with some arguing that behavior promotes evolution by exposing organisms to selection (behavioral drive) and others proposing that it inhibits evolution by shielding organisms from environmental variation (behavioral inertia). However, this discussion has generally focused on the effects of behavior along a single axis without considering that behavior simultaneously influences selection in various niche dimensions. By examining evolutionary change along two distinct niche axes-structural and thermal-we propose that behavior simultaneously drives and impedes evolution in a group of Anolis lizards from the Caribbean island of Hispaniola. Specifically, a behavioral shift in microhabitat to boulders at high altitude enables thermoregulation, thus forestalling physiological evolution in spite of colder environments. This same behavioral shift drives skull and limb evolution to boulder use. Our results emphasize the multidimensional effects of behavior in evolution. These findings reveal how, rather than being diametrically opposed, niche conservatism and niche lability can occur simultaneously. Furthermore, patterns of niche evolution may vary at different geographic scales: because of thermoregulatory behavior, lizards at high and low elevation share similar microclimatic niches (consistent with niche conservatism) while inhabiting distinct macroclimatic environments (consistent with niche divergence). Together, our results suggest that behavior can connect patterns of niche divergence and conservatism at different geographic scales and among traits.

  12. Simultaneous Voltammetric/Amperometric Determination of Sulfide and Nitrite in Water at BDD Electrode

    Directory of Open Access Journals (Sweden)

    Anamaria Baciu

    2015-06-01

    Full Text Available This work reported new voltammetric/amperometric-based protocols using a commercial boron-doped diamond (BDD electrode for simple and fast simultaneous detection of sulfide and nitrite from water. Square-wave voltammetry operated under the optimized working conditions of 0.01 V step potential, 0.5 V modulation amplitude and 10 Hz frequency allowed achieving the best electroanalytical parameters for the simultaneous detection of nitrite and sulfide. For practical in-field detection applications, the multiple-pulsed amperometry technique was operated under optimized conditions, i.e., −0.5 V/SCE for a duration of 0.3 s as conditioning step, +0.85 V/SCE for a duration of 3 s that assure the sulfide oxidation and +1.25 V/SCE for a duration of 0.3 s, where the nitrite oxidation occurred, which allowed the simultaneously detection of sulfide and nitrite without interference between them. Good accuracy was found for this protocol in comparison with standardized methods for each anion. Also, no interference effect was found for the cation and anion species, which are common in the water matrix.

  13. Simultaneous heating and compression of irradiated graphite during synchrotron microtomographic imaging

    Science.gov (United States)

    Bodey, A. J.; Mileeva, Z.; Lowe, T.; Williamson-Brown, E.; Eastwood, D. S.; Simpson, C.; Titarenko, V.; Jones, A. N.; Rau, C.; Mummery, P. M.

    2017-06-01

    Nuclear graphite is used as a neutron moderator in fission power stations. To investigate the microstructural changes that occur during such use, it has been studied for the first time by X-ray microtomography with in situ heating and compression. This experiment was the first to involve simultaneous heating and mechanical loading of radioactive samples at Diamond Light Source, and represented the first study of radioactive materials at the Diamond-Manchester Imaging Branchline I13-2. Engineering methods and safety protocols were developed to ensure the safe containment of irradiated graphite as it was simultaneously compressed to 450N in a Deben 10kN Open-Frame Rig and heated to 300°C with dual focused infrared lamps. Central to safe containment was a double containment vessel which prevented escape of airborne particulates while enabling compression via a moveable ram and the transmission of infrared light to the sample. Temperature measurements were made in situ via thermocouple readout. During heating and compression, samples were simultaneously rotated and imaged with polychromatic X-rays. The resulting microtomograms are being studied via digital volume correlation to provide insights into how thermal expansion coefficients and microstructure are affected by irradiation history, load and heat. Such information will be key to improving the accuracy of graphite degradation models which inform safety margins at power stations.

  14. Service Restoration Method Considering Simultaneous Disconnection of Distributed Generators by One Bank Fault of Distribution System

    Science.gov (United States)

    Takano, Hirotaka; Hayashi, Yasuhiro; Matsuki, Junya; Kobayashi, Naoki

    Distributed generators (DGs) such as fuel cells and solar cells etc. are going to be installed in demand side of distribution systems. The distributed generators can reduce distribution loss by appropriate allocation. However, there are several problems to install DGs such as service restoration of distribution system with DGs and so on. When one bank fault of distribution substation occurs in distribution system, since DGs are simultaneously disconnected from the system, it is not easy to restore isolated load by one bank switching in distribution substation. Therefore, a service restoration method to determine restoration configuration and restoration procedures (switching procedure from normal configuration to restoration configuration) taking into account simultaneous disconnection of DGs is needed. In this paper, the authors propose a computation method to determine the optimal restoration configuration and the restoration procedure considering simultaneous disconnection of DGs by one bank fault of distribution system. In the proposed algorithm, after all of restoration configuration candidates are effectively enumerated under the operational constraints, the optimal configuration to restore the isolated load is selected among enumerated configuration candidates. After determining the optimal restoration configuration, the optimal restoration procedures are obtained by greedy algorithm. Numerical simulations are carried out for a real scale system model with 237 sectionalizing switches (configuration candidates are 2237) and 21DGs (total output is 5250kW which is 3% of total load) in order to examine the validity of the proposed algorithm.

  15. Simultaneous Dropwise and Filmwise Condensation on a Microstructured Surface without the Assistance of a Hydrophobic Coating

    Science.gov (United States)

    Orejon, Daniel; Shardt, Orest; Kumar Gunda, Naga Siva; Ikuta, Tatsuya; Takahashi, Koji; Mitra, Sushanta K.; Takata, Yasuyuki

    2017-11-01

    We demonstrate micropillar surfaces on which condensation occurs in a new mode with simultaneous dropwise/filmwise condensation (DWC/FWC). This is achieved without the assistance of a hydrophobic coating; the pillars and base surface are hydrophilic. By considering thermodynamic principles of droplet wetting and spreading, we designed microstructured surfaces where the condensate is able to spread through the structures. The geometry of the microstructures constrains the condensate between the pillars, the rise of condensate above the structures is not thermodynamically favorable and condensation takes place as FWC between pillars. At the same time, the continuous nucleation, growth and departure of droplets at the pillars' tops in a DWC fashion is observed. We propose a simple resistance based heat transfer model to support the greater heat transfer performance of the simultaneous DWC/FWC when compared to solely FWC. In addition we propose rational guidelines for the design of an optimum configuration that maximizes the heat transfer performance in the simultaneous DWC/FWC mode. The authors acknowledge the support of WPI-I2CNER and KAKENHI JSPS.

  16. Alveolar Ridge Reconstruction with Titanium Meshes and Simultaneous Implant Placement: A Retrospective, Multicenter Clinical Study

    Science.gov (United States)

    Paraud Freixas, Andres; Han, Chang-Hun; Bechara, Sohueil; Tawil, Isaac

    2016-01-01

    Objective. To evaluate horizontal bone gain and implant survival and complication rates in patients treated with titanium meshes placed simultaneously with dental implants and fixed over them. Methods. Twenty-five patients treated with 40 implants and simultaneous guided bone regeneration with titanium meshes (i–Gen®, MegaGen, Gyeongbuk, Republic of Korea) were selected for inclusion in the present retrospective multicenter study. Primary outcomes were horizontal bone gain and implant survival; secondary outcomes were biological and prosthetic complications. Results. After the removal of titanium meshes, the CBCT evaluation revealed a mean horizontal bone gain of 3.67 mm (±0.89). The most frequent complications were mild postoperative edema (12/25 patients: 48%) and discomfort after surgery (10/25 patients: 40%); these complications were resolved within one week. Titanium mesh exposure occurred in 6 patients (6/25 : 24%): one of these suffered partial loss of the graft and another experienced complete graft loss and implant failure. An implant survival rate of 97.5% (implant-based) and a peri-implant marginal bone loss of 0.43 mm (±0.15) were recorded after 1 year. Conclusions. The horizontal ridge reconstruction with titanium meshes placed simultaneously with dental implants achieved predictable satisfactory results. Prospective randomized controlled trials on a larger sample of patients are required to validate these positive outcomes. PMID:27999799

  17. Alveolar Ridge Reconstruction with Titanium Meshes and Simultaneous Implant Placement: A Retrospective, Multicenter Clinical Study

    Directory of Open Access Journals (Sweden)

    Raquel Zita Gomes

    2016-01-01

    Full Text Available Objective. To evaluate horizontal bone gain and implant survival and complication rates in patients treated with titanium meshes placed simultaneously with dental implants and fixed over them. Methods. Twenty-five patients treated with 40 implants and simultaneous guided bone regeneration with titanium meshes (i–Gen®, MegaGen, Gyeongbuk, Republic of Korea were selected for inclusion in the present retrospective multicenter study. Primary outcomes were horizontal bone gain and implant survival; secondary outcomes were biological and prosthetic complications. Results. After the removal of titanium meshes, the CBCT evaluation revealed a mean horizontal bone gain of 3.67 mm (±0.89. The most frequent complications were mild postoperative edema (12/25 patients: 48% and discomfort after surgery (10/25 patients: 40%; these complications were resolved within one week. Titanium mesh exposure occurred in 6 patients (6/25 : 24%: one of these suffered partial loss of the graft and another experienced complete graft loss and implant failure. An implant survival rate of 97.5% (implant-based and a peri-implant marginal bone loss of 0.43 mm (±0.15 were recorded after 1 year. Conclusions. The horizontal ridge reconstruction with titanium meshes placed simultaneously with dental implants achieved predictable satisfactory results. Prospective randomized controlled trials on a larger sample of patients are required to validate these positive outcomes.

  18. Simultaneity: A Question of Time, Space, Resources and Purpose

    National Research Council Canada - National Science Library

    Hedstrom, Marvin

    2001-01-01

    ...) domains, simultaneity allows momentum and tempo to build; thus rapidly transferring the synergistic effects from the domains of action to the moral domain leading to a rapid, decisive loss of cohesion within the enemy...

  19. SIMULTANEOUS INTEGRATION OF WATER AND ENERGY: ACHIEVEMENTS AND CHALLENGES

    Directory of Open Access Journals (Sweden)

    Junior Lorenzo Llanes

    2016-01-01

    Full Text Available Process Integration (PI is a tool that for over forty years has demonstrated its strength to provide optimal solutions to complex problems. The interaction of exchange systems of energy and water networks is a typical case of such problems. The gradual increase in the consumption of water and energy has determined the development of methodologies that take into account the simultaneous integration of these resources. This paper aims to present a literature review related to the simultaneous integration of water and energy. First, general items related to this research field are presented, emphasizing the approaches to simultaneous integration (Pinch Analysis and Mathematical Programming. Some recent cases of studies, demonstrating the strength of these tools mainly focus to sugar industry, are also presented. Finally some of the challenges to be faced by the simultaneous integration of water and energy for the diversification of the Cuban sugar industry are presented.

  20. Simultaneous Determination of Two Isomers of Asarone in Piper ...

    African Journals Online (AJOL)

    Simultaneous Determination of Two Isomers of Asarone in Piper sarmentosum Roxburgh (Piperaceae) Extracts using Different Chromatographic Columns. Mohd Shahrul Ridzuan Hamil, Abdul Hakeem Memon, Amin Malik Shah Abdul Majid, Zhari Ismail ...

  1. Simultaneous Temperature and Velocity Diagnostic for Reacting Flows Project

    Data.gov (United States)

    National Aeronautics and Space Administration — A diagnostic technique is proposed for measuring temperature and velocity simultaneously in a high temperature reacting flow for aiding research in propulsion. The...

  2. Toward Wing Aerostructural Optimization Using Simultaneous Analysis and Design Strategy

    NARCIS (Netherlands)

    Elham, A.; van Tooren, M.J.L.

    2017-01-01

    The application and computational efficiency of wing aerostructural optimization us- ing simultaneous analysis and design (SAND) strategy is investigated. A coupled adjoint aerostructural analysis method based on quasi-three-dimensional aerodynamic analysis is used for this research. Two different

  3. Short-term effects of simultaneous cardiovascular workout and ...

    African Journals Online (AJOL)

    PMD), has become a growing public health concern, as it may potentially result in the development of hearing difficulties. Objectives: The aim of the study was to determine the differential impact and short-term effects of simultaneous ...

  4. Simultaneous Temperature and Velocity Diagnostic for Reacting Flows, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — A diagnostic technique is proposed for measuring temperature and velocity simultaneously in a high temperature reacting flow for aiding research in propulsion. The...

  5. Stability-Indicating HPLC Method for the Simultaneous ...

    African Journals Online (AJOL)

    phase HPLC stability- indicating method for the simultaneous estimation of ... It is a class of lipid-lowering agent that selectively inhibits the intestinal ... room temperature, neutralised (for acidic and basic degradation) and diluted with the mobile.

  6. The Concept of "Simultaneous Feedback": Towards a New Meth ...

    African Journals Online (AJOL)

    gual Cilubà-Dutch learner's dictionary. It is shown how this main project has been successfully complemented by three parallel projects. Keywords: SIMULTANEOUS FEEDBACK, NEW METHODOLOGY, MAIN DICTIONARY,. PARALLEL DICTIONARIES, TARGET USERS' DESIRES, QUESTIONNAIRES, ELECTRONIC.

  7. Simultaneous Localization and Mapping for Satellite Rendezvous and Proximity Operations

    Data.gov (United States)

    National Aeronautics and Space Administration — Simultaneous Localization and Mapping (SLAM) attempts to estimate a vehicle’s position and orientation (localization) and the location of an initially unknown number...

  8. The prevention and treatment of biliary complications occurred after CT-guided percutaneous radiofrequency ablation for hepatic neoplasms

    International Nuclear Information System (INIS)

    Li Jianjun; Zheng Jiasheng; Cui Xiongwei; Cui Shichang; Sun Bin

    2011-01-01

    Objective: To discuss the prevention and treatment of biliary complications occurred after CT-guided percutaneous radiofrequency ablation (RFA) for hepatic neoplasms. Methods: A total of 1136 patients, including 920 males and 216 females, with hepatic neoplasms were enrolled in this study. The hepatic tumors consisted of primary hepatocellular carcinoma (n=1037), hepatic metastasis (n=83) and hepatic cavernous hemangioma (n=16). The diameters of the tumors ranged from 0.5 to 16 cm. A total of 1944 RFA procedures were carried out in all patients. Results: Thirty-five patients developed biliary complication (35/1944, 1.80%). Twelve patients developed asymptomatic bile duct dilatation and no special treatment was given. Obstructive jaundice occurred in two patients and percutaneous transhepatic cholangiocholecystic drainage (PTCD) together with subsequent inner stent implantation had to be carried out. Eighteen patients developed biloma, and liver abscess formation secondary to biloma infection occurred in seven of them. Percutaneous transhepatic biloma drainage (PTBD) was adopted in all these patients. One patient suffered from obstructive jaundice complicated by biloma, and both PTCD and PTBD combined with inner stent implantation were simultaneously performed. One patient had the biloma secondary to obstructive jaundice, and PTCD followed by PTBD was conducted in turn. One patient developed obstructive jaundice secondary to biloma, and PTBD followed by PTCD was employed in turn. Conclusion: Obstructive jaundice and biloma are severe biliary complications occurred after CT-guided percutaneous radiofrequency ablation for hepatic tumors, and PTCD and/or PTBD should be carried out without delay to treat these complications. The clinical symptoms can be relieved, or even completely disappear, after treatment. (authors)

  9. Simultaneous Bilateral Flexion-Type Salter-Harris II Fractures of the Proximal Tibia: A Case Report and Review of the Literature

    Science.gov (United States)

    Potenza, V.; Caterini, R; Maglione, P; Bisicchia, S; Farsetti, P

    2011-01-01

    A rare case is reported of bilateral physeal lesions of the proximal tibia classified as Salter-Harris type II, which occurred simultaneously after a “flexion type” injury in a 14-year-old boy. Treatment was conservative on the nondisplaced side and surgical, by closed reduction and internal fixation, on the displaced side. There was no previous diagnosis of Osgood-Schlatter disease. After reviewing all the cases described previously, which occurred either consecutively or simultaneously, we conclude that less resistance of the growth plate, typical of late adolescence, likely represents the cause of this type of lesion. PMID:21886687

  10. Simultaneous Bilateral Flexion-Type Salter-Harris II Fractures of the Proximal Tibia: A Case Report and Review of the Literature.

    Science.gov (United States)

    Potenza, V; Caterini, R; Maglione, P; Bisicchia, S; Farsetti, P

    2011-01-01

    A rare case is reported of bilateral physeal lesions of the proximal tibia classified as Salter-Harris type II, which occurred simultaneously after a "flexion type" injury in a 14-year-old boy. Treatment was conservative on the nondisplaced side and surgical, by closed reduction and internal fixation, on the displaced side. There was no previous diagnosis of Osgood-Schlatter disease. After reviewing all the cases described previously, which occurred either consecutively or simultaneously, we conclude that less resistance of the growth plate, typical of late adolescence, likely represents the cause of this type of lesion.

  11. Simultaneous carbonation and sulfation of CaO in Oxy-Fuel CFB combustion

    Energy Technology Data Exchange (ETDEWEB)

    Wang, C. [School of Energy and Power Engineering, North China Electric Power University, Baoding City, Hebei Province (China); Jia, L.; Tan, Y. [CanmetENERGY, 1 Haanel Drive, Ottawa, Ontario, K1A 1M1 (Canada)

    2011-10-15

    For anthracites and petroleum cokes, the typical combustion temperature in a circulating fluidized bed (CFB) is > 900 C. At CO{sub 2} concentrations of 80-85 % (typical of oxy-fuel CFBC conditions), limestone still calcines. When the ash which includes unreacted CaO cools to the calcination temperature, carbonation of fly ash deposited on cool surfaces may occur. At the same time, indirect and direct sulfation of limestone also will occur, possibly leading to more deposition. In this study, CaO was carbonated and sulfated simultaneously in a thermogravimetric analyzer (TGA) under conditions expected in an oxy-fuel CFBC. It was found that temperature, and concentrations of CO{sub 2}, SO{sub 2}, and especially H{sub 2}O are important factors in determining the carbonation/sulfation reactions of CaO. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  12. Simultaneous and non-simultaneous blow-up and uniform blow-up profiles for reaction-diffusion system

    Directory of Open Access Journals (Sweden)

    Zhengqiu Ling

    2012-11-01

    Full Text Available This article concerns the blow-up solutions of a reaction-diffusion system with nonlocal sources, subject to the homogeneous Dirichlet boundary conditions. The criteria used to identify simultaneous and non-simultaneous blow-up of solutions by using the parameters p and q in the model are proposed. Also, the uniform blow-up profiles in the interior domain are established.

  13. Simultaneous trimodal MR-PET-EEG imaging for the investigation of resting state networks in humans

    Energy Technology Data Exchange (ETDEWEB)

    Neuner, Irene [RWTH Aachen (Germany); Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich GmbH (Germany); Mauler, Joerg; Arrubla, Jorge; Kops, Elena Rota; Tellmann, Lutz; Scheins, Jurgen; Herzog, Hans [Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich GmbH (Germany); Langen, Karl Josef; Shah, Jon [RWTH Aachen (Germany)

    2015-05-18

    Glucose is the principal source of energy for the brain and its relationship to neuronal activity are poorly understood. The human brain uses 80% of its energy for ongoing neural activity that occurs in isolation from any particular stimulus. A promising tool for the investigation of glucose metabolism and its relationship to neuronal activity is simultaneous trimodal MR-PET-EEG data imaging. We here demonstrate the first in vivo human trimodal data at 3T. In one session MR, FDG-PET and EEG data were recorded simultaneously at a 3T hybrid MR-BrainPET scanner (Siemens, Germany) equipped with a 32 channel MR-compatible EEG system (Brain Products, Germany) in 11 healthy volunteers (11 males, mean age: 25.2 years SD: 1.2). MR and EEG data acquisition MP-RAGE (TR = 2250 ms, TE= 3.03 ms, 176 sagittal slices. 1 mm, GRAPPA factor 2. MR-based attenuation correction of PET data via UTE: flip angle=15. Two different echo times TE1=0.07 and TE2=2.46 ms, TR=200 ms. EPI sequence (TR: 2.2 s, TE: 30 ms, FOV: 200 mm, 165 volumes, The subjects were requested to close their eyes and relax EEG data were recorded using a 32-channel MR compatible EEG system. App. 200 MBq/μmol FDG were injected, data were acquired in list mode and iteratively reconstructed with all necessary corrections into 153 slices with 256 x 256 voxels sized 1.25 mm{sup 3}. The trimodal approach, recording PET data, MR data and EEG data simultaneously was successful. The high neuronal activity of the structures within the default mode network occurs on the basis of a high glucose consumption rate within the default node network. The activity of the default mode is not tied to a special EEG frequency band.

  14. Implications of the simultaneous occurrence of glycolysis and gluconeogenesis in hepatocytes from normal and hyperthyroid rats

    International Nuclear Information System (INIS)

    Phillips, J.W.; Berry, M.N.

    2001-01-01

    The mammalian liver has the capability for both glycolysis and gluconeogenesis. In the fasting state, metabolites such as lactate and glycerol, generated in the peripheral tissues, are taken up by the liver and converted to glucose. However, hepatocytes from fasted animals are also capable of substantial rates of glycolysis. It is generally assumed that glycolysis and gluconeogenesis do not occur simultaneously in the same cell, but rather the metabolic conditions that facilitate flux through one pathway impair flow in the opposite direction. The actual direction of flow at any given moment is thought to be determined by regulatory mechanisms that control flux through the enzymatic steps specific to glycolysis and gluconeogenesis. The rates of glycolysis from [6- 3 H]glucose and gluconeogenesis from [U- 14 C]glycerol were determined in isolated hepatocytes from fasted normal and hyperthyroid rats. We observed that glycolysis from glucose and glucose synthesis from glycerol occurred simultaneously at substantial rates in hepatocytes from normal rats and that gluconeogenesis, but not glycolysis, was increased twofold in hepatocytes from thyroid treated rats. In the hyperthyroid state, the rate of glycolysis from glucose was approximately equal to the rate of glucose formation from glycerol. Hence, metabolism and ATP turnover were stimulated without substantially altering steady-state concentrations of glucose. The concomitant operation of hepatic glycolysis and gluconeogenesis may be a mechanism that accounts in part for the calorigenic effect of thyroid hormone. Since hepatocyles are generally impermeable to phosphorylated metabolites, our observations suggest that glycolysis, and phosphorylation of glycerol take place in the same cells, and that the occurrence of simultaneous glycolysis and gluconeogenesis is an indication of channelling within the hepatocyte cytoplasm of individual hepatocytes

  15. A structured overview of simultaneous component based data integration

    Directory of Open Access Journals (Sweden)

    van der Werf Mariët J

    2009-08-01

    Full Text Available Abstract Background Data integration is currently one of the main challenges in the biomedical sciences. Often different pieces of information are gathered on the same set of entities (e.g., tissues, culture samples, biomolecules with the different pieces stemming, for example, from different measurement techniques. This implies that more and more data appear that consist of two or more data arrays that have a shared mode. An integrative analysis of such coupled data should be based on a simultaneous analysis of all data arrays. In this respect, the family of simultaneous component methods (e.g., SUM-PCA, unrestricted PCovR, MFA, STATIS, and SCA-P is a natural choice. Yet, different simultaneous component methods may lead to quite different results. Results We offer a structured overview of simultaneous component methods that frames them in a principal components setting such that both the common core of the methods and the specific elements with regard to which they differ are highlighted. An overview of principles is given that may guide the data analyst in choosing an appropriate simultaneous component method. Several theoretical and practical issues are illustrated with an empirical example on metabolomics data for Escherichia coli as obtained with different analytical chemical measurement methods. Conclusion Of the aspects in which the simultaneous component methods differ, pre-processing and weighting are consequential. Especially, the type of weighting of the different matrices is essential for simultaneous component analysis. These types are shown to be linked to different specifications of the idea of a fair integration of the different coupled arrays.

  16. A flexible framework for sparse simultaneous component based data integration

    Directory of Open Access Journals (Sweden)

    Van Deun Katrijn

    2011-11-01

    Full Text Available Abstract 1 Background High throughput data are complex and methods that reveal structure underlying the data are most useful. Principal component analysis, frequently implemented as a singular value decomposition, is a popular technique in this respect. Nowadays often the challenge is to reveal structure in several sources of information (e.g., transcriptomics, proteomics that are available for the same biological entities under study. Simultaneous component methods are most promising in this respect. However, the interpretation of the principal and simultaneous components is often daunting because contributions of each of the biomolecules (transcripts, proteins have to be taken into account. 2 Results We propose a sparse simultaneous component method that makes many of the parameters redundant by shrinking them to zero. It includes principal component analysis, sparse principal component analysis, and ordinary simultaneous component analysis as special cases. Several penalties can be tuned that account in different ways for the block structure present in the integrated data. This yields known sparse approaches as the lasso, the ridge penalty, the elastic net, the group lasso, sparse group lasso, and elitist lasso. In addition, the algorithmic results can be easily transposed to the context of regression. Metabolomics data obtained with two measurement platforms for the same set of Escherichia coli samples are used to illustrate the proposed methodology and the properties of different penalties with respect to sparseness across and within data blocks. 3 Conclusion Sparse simultaneous component analysis is a useful method for data integration: First, simultaneous analyses of multiple blocks offer advantages over sequential and separate analyses and second, interpretation of the results is highly facilitated by their sparseness. The approach offered is flexible and allows to take the block structure in different ways into account. As such

  17. A flexible framework for sparse simultaneous component based data integration.

    Science.gov (United States)

    Van Deun, Katrijn; Wilderjans, Tom F; van den Berg, Robert A; Antoniadis, Anestis; Van Mechelen, Iven

    2011-11-15

    High throughput data are complex and methods that reveal structure underlying the data are most useful. Principal component analysis, frequently implemented as a singular value decomposition, is a popular technique in this respect. Nowadays often the challenge is to reveal structure in several sources of information (e.g., transcriptomics, proteomics) that are available for the same biological entities under study. Simultaneous component methods are most promising in this respect. However, the interpretation of the principal and simultaneous components is often daunting because contributions of each of the biomolecules (transcripts, proteins) have to be taken into account. We propose a sparse simultaneous component method that makes many of the parameters redundant by shrinking them to zero. It includes principal component analysis, sparse principal component analysis, and ordinary simultaneous component analysis as special cases. Several penalties can be tuned that account in different ways for the block structure present in the integrated data. This yields known sparse approaches as the lasso, the ridge penalty, the elastic net, the group lasso, sparse group lasso, and elitist lasso. In addition, the algorithmic results can be easily transposed to the context of regression. Metabolomics data obtained with two measurement platforms for the same set of Escherichia coli samples are used to illustrate the proposed methodology and the properties of different penalties with respect to sparseness across and within data blocks. Sparse simultaneous component analysis is a useful method for data integration: First, simultaneous analyses of multiple blocks offer advantages over sequential and separate analyses and second, interpretation of the results is highly facilitated by their sparseness. The approach offered is flexible and allows to take the block structure in different ways into account. As such, structures can be found that are exclusively tied to one data platform

  18. A flexible framework for sparse simultaneous component based data integration

    Science.gov (United States)

    2011-01-01

    1 Background High throughput data are complex and methods that reveal structure underlying the data are most useful. Principal component analysis, frequently implemented as a singular value decomposition, is a popular technique in this respect. Nowadays often the challenge is to reveal structure in several sources of information (e.g., transcriptomics, proteomics) that are available for the same biological entities under study. Simultaneous component methods are most promising in this respect. However, the interpretation of the principal and simultaneous components is often daunting because contributions of each of the biomolecules (transcripts, proteins) have to be taken into account. 2 Results We propose a sparse simultaneous component method that makes many of the parameters redundant by shrinking them to zero. It includes principal component analysis, sparse principal component analysis, and ordinary simultaneous component analysis as special cases. Several penalties can be tuned that account in different ways for the block structure present in the integrated data. This yields known sparse approaches as the lasso, the ridge penalty, the elastic net, the group lasso, sparse group lasso, and elitist lasso. In addition, the algorithmic results can be easily transposed to the context of regression. Metabolomics data obtained with two measurement platforms for the same set of Escherichia coli samples are used to illustrate the proposed methodology and the properties of different penalties with respect to sparseness across and within data blocks. 3 Conclusion Sparse simultaneous component analysis is a useful method for data integration: First, simultaneous analyses of multiple blocks offer advantages over sequential and separate analyses and second, interpretation of the results is highly facilitated by their sparseness. The approach offered is flexible and allows to take the block structure in different ways into account. As such, structures can be found that are

  19. Simultaneous pressure measurement and high-speed photography study of cavitation in a dynamically loaded journal bearing

    Science.gov (United States)

    Sun, D. C.; Brewe, David E.; Abel, Philip B.

    1994-01-01

    Cavitation of the oil film in a dynamically loaded journal bearing was studied using high-speed photography and pressure measurement simultaneously. Comparison of the visual and pressure data provided considerable insight into the occurrence and nonoccurrence of cavitation. It was found that (1) for the submerged journal bearing, cavitation typically occurred in the form of one bubble with the pressure in the cavitation bubble close to the absolute zero; and (2) for cavitation-producing operating conditions, cavitation did not always occur; with the oil film then supporting a tensile stress.

  20. David Malament and the Conventionality of Simultaneity: A Reply

    Science.gov (United States)

    Grünbaum, Adolf

    2010-10-01

    In 1977, David Malament proved the valuable technical result that the simultaneity relation of standard synchrony ɛ=1/2 with respect to an inertial observer O is uniquely definable in terms of the relation κ of causal connectibility. And he claimed that this definability undermines my own version of the conventionality of metrical simultaneity within an inertial frame. But Malament’s proof depends on the imposition of several supposedly “innocuous” constraints on any candidate for the simultaneity relation relative to O. Relying on Allen I. Janis’s 1983 challenge to one of these constraints, I argue that Malament’s technical result did not undermine my philosophical construal of the ontological status of relative metrical simultaneity. Furthermore, I show that (a) Michael Friedman’s peremptorily substantivalist critique of my conception, which Malament endorses, is ill-founded, and (b) if Malament had succeeded in discrediting my own conventionalist version of metrical simultaneity, he would likewise have invalidated Einstein’s pioneering version of it.

  1. Evidence for the treatment of co-occurring stuttering and speech sound disorder: A clinical case series.

    Science.gov (United States)

    Unicomb, Rachael; Hewat, Sally; Spencer, Elizabeth; Harrison, Elisabeth

    2017-06-01

    There is a paucity of evidence to guide treatment for children with co-occurring stuttering and speech sound disorder. Some guidelines suggest treating the two disorders simultaneously using indirect treatment approaches; however, the research supporting these recommendations is over 20 years old. In this clinical case series, we investigate whether these co-occurring disorders could be treated concurrently using direct treatment approaches supported by up-to-date, high-level evidence, and whether this could be done in an efficacious, safe and efficient manner. Five pre-school-aged participants received individual concurrent, direct intervention for both stuttering and speech sound disorder. All participants used the Lidcombe Program, as manualised. Direct treatment for speech sound disorder was individualised based on analysis of each child's sound system. At 12 months post commencement of treatment, all except one participant had completed the Lidcombe Program, and were less than 1.0% syllables stuttered on samples gathered within and beyond the clinic. These four participants completed Stage 1 of the Lidcombe Program in between 14 and 22 clinic visits, consistent with current benchmark data for this programme. At the same assessment point, all five participants exhibited significant increases in percentage of consonants correct and were in alignment with age-expected estimates of this measure. Further, they were treated in an average number of clinic visits that compares favourably with other research on treatment for speech sound disorder. These preliminary results indicate that young children with co-occurring stuttering and speech sound disorder may be treated concurrently using direct treatment approaches. This method of service delivery may have implications for cost and time efficiency and may also address the crucial need for early intervention in both disorders. These positive findings highlight the need for further research in the area and contribute to

  2. Efficient nitrogen removal via simultaneous nitrification and denitrification in a penicillin wastewater biological treatment plant.

    Science.gov (United States)

    Luo, Weiwei; Jin, Xibiao; Yu, Yonglian; Zhou, Sichen; Lu, Shuguang

    2014-01-01

    Nitrogen-removal performance was investigated in a penicillin wastewater biological treatment plant (P-WWTP) reconstructed from a cyclic activated sludge system (CASS) tank designed for simultaneous nitrification and denitrification (SND). Good performance was obtained during a 900-day operation period, as indicated by effluent chemical oxygen demand (COD), total nitrogen (TN) and ammonia nitrogen (NH₃‒N) values of 318 ± 34, 28.7 ± 2.4 anddenitrification occurred at different spaces, that is, 71.4% of TN removal occurred in the first 40% of the aeration tank, while 68.8% of the TKN removal occurred in 40-100% of the aeration tank. Sufficient easily biodegradable organics (EBO) in wastewater were key to the occurrence of SND. The denitrification rate under aeration conditions was 10.7 mg N g VSS⁻¹ h⁻¹ when EBO were sufficient, but 0.98 mg N g VSS⁻¹ h⁻¹ when EBO were completely degraded. Nitrification primarily occurred in the rear of the aeration tank owing to the competition for oxygen between carbonaceous oxidation and nitrification. The nitrification rate was only 7.13 mg NOD g VSS⁻¹ h⁻¹ at the beginning of the reaction, but 14.7 mg NOD g VSS⁻¹ h⁻¹ when EBO were completely degraded. These results will facilitate the improvement of nitrogen removal by existing WWTPs.

  3. Simultaneous vibration isolation and pointing control of flexure jointed hexapods

    Science.gov (United States)

    Li, Xiaochun; Hamann, Jerry C.; McInroy, John E.

    2001-08-01

    Vibration isolation and precision pointing problems using hexapods have been separately investigated by several groups of researchers. Since many applications require simultaneous vibration isolation and precision pointing (e.g., telescopes, laser communication, and laser weapons), it is particularly useful to do both with a single device. A simultaneous control scheme is developed in this paper using acceleration feedback to provide high-frequency vibration isolation, while Cartesian pointing feedback provides low-frequency pointing. The compensation is divided by frequency because pointing sensors often have a low bandwidth, while acceleration sensors often have a poor low-frequency response. Methods for unifying these finite bandwidth joint and Cartesian controls to perform simultaneous pointing and vibration isolation on a single platform are developed and verified. Experiments on the University of Wyoming hexapods show that this scheme provides a viable control bandwidth.

  4. Simultaneous in vivo truncation of pectic side chains

    DEFF Research Database (Denmark)

    Øbro, Jens; Borkhardt, Bernhard; Harholt, Jesper

    2009-01-01

    . These modifications often prevent gelation, which has been a major functional requirement of commercial pectins until recently. We have previously shown that modification of pectin is possible through heterologous expression of pectin degrading enzymes in planta. To test the effect of simultaneous modification......Despite the wide occurrence of pectin in nature only a few source materials have been used to produce commercial pectins. One of the reasons for this is that many plant species contain pectins with high levels of neutral sugar side chains or that are highly substituted with acetyl or other groups...... of the two main neutral pectic side chains in pectic rhamnogalacturonan I (RGI), we constitutively expressed two different enzymes in Arabidopsis thaliana that would either modify the galactan or the arabinan side chains, or both side chains simultaneously. Our analysis showed that the simultaneous...

  5. Iterative methods for simultaneous inclusion of polynomial zeros

    CERN Document Server

    Petković, Miodrag

    1989-01-01

    The simultaneous inclusion of polynomial complex zeros is a crucial problem in numerical analysis. Rapidly converging algorithms are presented in these notes, including convergence analysis in terms of circular regions, and in complex arithmetic. Parallel circular iterations, where the approximations to the zeros have the form of circular regions containing these zeros, are efficient because they also provide error estimates. There are at present no book publications on this topic and one of the aims of this book is to collect most of the algorithms produced in the last 15 years. To decrease the high computational cost of interval methods, several effective iterative processes for the simultaneous inclusion of polynomial zeros which combine the efficiency of ordinary floating-point arithmetic with the accuracy control that may be obtained by the interval methods, are set down, and their computational efficiency is described. The rate of these methods is of interest in designing a package for the simultaneous ...

  6. Disposable penis and its replenishment in a simultaneous hermaphrodite

    Science.gov (United States)

    Sekizawa, Ayami; Seki, Satoko; Tokuzato, Masakazu; Shiga, Sakiko; Nakashima, Yasuhiro

    2013-01-01

    Although it is often thought that sexual selection is weaker in simultaneous hermaphrodites than in gonochorists, some simultaneous hermaphrodites exhibit bizarre mating behaviour. In the simultaneously hermaphroditic nudibranch Chromodoris reticulata, we found a peculiar mating behaviour, wherein the nudibranch autotomized its penis after each copulation and was able to copulate again within 24 h. To have sufficient length to be replenished for three copulations, the penis is compressed and spiralled internally. No other animal is known to repeatedly copulate using such ‘disposable penes’. Entangled sperm masses were observed on the outer surface of the autotomized penis, which is equipped with many backward-pointed spines. There is a possibility that the nudibranch removes sperm already stored in a mating partner's sperm storage organ(s). PMID:23407499

  7. High-pressure cell for simultaneous dielectric and neutron spectroscopy

    DEFF Research Database (Denmark)

    Sanz, Alejandro; Hansen, Henriette Wase; Jakobsen, Bo

    2018-01-01

    and fast vibrations at the same time. The cell, constructed in cylindrical geometry, is made of a high-strength aluminum alloy and operates up to 500 MPa in a temperature range between roughly 2 and 320 K. In order to measure the scattered neutron intensity and the sample capacitance simultaneously......In this article, we report on the design, manufacture, and testing of a high-pressure cell for simultaneous dielectric and neutron spectroscopy. This cell is a unique tool for studying dynamics on different time scales, from kilo- to picoseconds, covering universal features such as the α relaxation......, a cylindrical capacitor is positioned within the bore of the high-pressure container. The capacitor consists of two concentric electrodes separated by insulating spacers. The performance of this setup has been successfully verified by collecting simultaneous dielectric and neutron spectroscopy data...

  8. Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic Syndrome

    Directory of Open Access Journals (Sweden)

    Stéphane Mathis

    2016-01-01

    Full Text Available Immune-mediated neuromuscular disorders include pathologies of the peripheral nervous system, neuromuscular junction, and muscles. If overlap syndromes (or the association of almost two autoimmune disorders are recognized, the simultaneous occurrence of several autoimmune neuromuscular disorders is rare. We describe two patients presenting the simultaneous occurrence of inflammatory neuropathy, myositis, and myasthenia gravis (with positive acetylcholine receptor antibodies. For each patient, we carried out a pathological analysis (nerve and muscle and an electrophysiological study (and follow-up. To our knowledge, this is the first description of such a triple immune-mediated neuromuscular syndrome. We compared our observations with a few other cases of simultaneous diagnosis of two inflammatory neuromuscular disorders.

  9. Characterization of low-temperature pyroclastic surges that occurred in the northeastern Japan arc during the late 19th century

    Science.gov (United States)

    Fujinawa, Akihiko; Ban, Masao; Ohba, Tsukasa; Kontani, Kazuo; Miura, Kotaro

    2008-11-01

    deposits might be attributable to poor thermally induced turbulence of eruption columns. Condensation of vapor in the surges might have contributed to the poor sorting. The estimated explosion energies were 6 × 10 13 J for Adatara AD1900, 6.5 × 10 10 J for Zao AD1895, and 6.5 × 10 15 J for Bandai AD1888, implying that the three events were hydrothermal eruptions with distinctive eruptive mechanisms. Regarding eruption sources, the Adatara 1900 event was caused solely by thermal energy of the hydrothermal fluid, although magma intrusion likely triggered evolution of hydrothermal systems at Zao in 1895. Steam eruptions in the Bandai 1888 event occurred simultaneously with sudden exposure of the hydrothermal system, whose triggers require no internal energy.

  10. Simultaneous assay of human placental lactogen and human chorionic gonadotropin

    International Nuclear Information System (INIS)

    Sivaprasad, N.; Kanchan, Kothari; Shah, K.B.; Mani, R.S.

    1981-01-01

    Simultaneous solid phase radioimmunoassay (RIA) for human chorionic gonadotropin (HCG) and human placental lactogen (HPL) has been developed. Anti HCG sera were coated on the inner surface of polypropylene tube (12x75 mm) and anti HPL sera were coated on the outer surface of polystyrene tubes (4x75 mm). The HCG and HPL tracers were prepared by labelling with iodine 125. High correlation was obtained between simultaneous assay and individual assay (for HCG correlation coefficient r=0.98 and for HPL r=0.96). (author)

  11. Simultaneous multiparticle emissions in hot nuclei evaporation process

    Energy Technology Data Exchange (ETDEWEB)

    Santos, B. M. [Instituto de Fisica - Universidade Federal Fluminense Av. Gal. Milton Tavares de Souza, 24210-346 Niteroi. RJ (Brazil); De Assis, L. P.; Duarte, S. B. [Centro Brasileiro de Pesquisas Fisicas - CBPF Rua Dr. Xavier Sigaud 150, 22290-180 Rio de Janeiro. RJ (Brazil)

    2013-03-25

    This work presents a new mechanism for the evaporation with simultaneous particles emission mechanism in the evaporation chain as new channels opened to high excitation energy regime of the compound nucleus. The probability of multiple simultaneous emissions is determined based on phase space approach. A Monte Carlo simulation is employed to compute the final average yield of emitted particles after the decay chain. The neutron, proton, alpha and fission yields are obtained and compared to the conventional calculation with sequential simple particles emission and the relevance of the different channels in competition is also analyzed.

  12. A case presentation of bilateral simultaneous Bell's palsy.

    Science.gov (United States)

    Kilic, Rahmi; Ozdek, Ali; Felek, Sevim; Safak, M Asim; Samim, Erdal

    2003-01-01

    Bilateral simultaneous facial paralysis is an extremely rare clinical entity. Unlike the unilateral form, bilateral facial paralysis seldom falls into Bell's category. It is most often a special finding in a symptom complex of a systemic disease; many of them are potentially life-threatening, and therefore the condition warrants urgent medical intervention. Lyme disease, Guillian-Barre syndrome, Bell's palsy, leukemia, sarcoidosis, bacterial meningitis, syphilis, leprosy, Moebius syndrome, infectious mononucleosis, and skull fracture are the most common cause of bilateral facial paralysis. Here we present a 16-year-old patient with bilateral simultaneous Bell's palsy.

  13. Simultaneous acquisition of physiological data and nuclear medicine images

    International Nuclear Information System (INIS)

    Rosenthal, M.S.; Klein, H.A.; Orenstein, S.R.

    1988-01-01

    A technique has been developed that allows the simultaneous acquisition of both image and physiological data into a standard nuclear medicine computer system. The physiological data can be displayed along with the nuclear medicine images allowing temporal correlation between the two. This technique has been used to acquire images of gastroesophageal reflux simultaneously with the intraluminal esophageal pH. The resulting data are displayed either as a standard dynamic sequence with the physiological data appearing in a corner of the image or as condensed dynamic images

  14. Simultaneous-equations Analysis in Regional Science and Economic Geography

    DEFF Research Database (Denmark)

    Mitze, Timo; Stephan, Andreas

    This paper provides an overview over simultaneous equation models (SEM) in the context of analyses based on regional data. We describe various modelling approaches and highlight close link of SEMs to theory and also comment on the advantages and disadvantages of SEMs.We present selected empirical...... works using simultaneous-equations analysis in regional science and economic geography in or-der to show the wide scope for applications. We thereby classify the empirical contributions as either being structural model presentations or vector autoregressive (VAR) models. Finally, we provide the reader...

  15. Bilateral Simultaneous Rhegmatogenous Retinal Detachment following Laser in situ Keratomileusis

    Directory of Open Access Journals (Sweden)

    Erhan Yumusak

    2016-06-01

    Full Text Available A 21-year-old woman developed simultaneous rhegmatogenous retinal detachment after laser in situ keratomileusis (LASIK in both eyes. She underwent pars plana vitrectomy surgery combined with endolaser photocoagulation and silicone oil tamponade in the right eye. A week later, pneumatic retinopexy was done in the left eye. As the retinal tear did not seal, 360° scleral buckling surgery was performed and retina was attached. Bilateral simultaneous rhegmatogenous retinal detachment after LASIK for correction of myopia can be a serious complication. Patients should be informed about the possibility of this complication.

  16. Simultaneous Optical and Electrical Recording of Single Gramicidin Channels

    OpenAIRE

    Borisenko, V.; Lougheed, T.; Hesse, J.; Füreder-Kitzmüller, E.; Fertig, N.; Behrends, J.C.; Woolley, G.A.; Schütz, G.J.

    2003-01-01

    We report here an approach for simultaneous fluorescence imaging and electrical recording of single ion channels in planar bilayer membranes. As a test case, fluorescently labeled (Cy3 and Cy5) gramicidin derivatives were imaged at the single-molecule level using far-field illumination and cooled CCD camera detection. Gramicidin monomers were observed to diffuse in the plane of the membrane with a diffusion coefficient of 3.3 × 10−8 cm2s−1. Simultaneous electrical recording detected gramicidi...

  17. Multiple simultaneous fabrication of molecular nanowires using nanoscale electrocrystallization

    International Nuclear Information System (INIS)

    Hasegawa, Hiroyuki; Ueda, Rieko; Kubota, Tohru; Mashiko, Shinro

    2006-01-01

    We carried out a multiple simultaneous fabrication based on the nanoscale electrocrystallization to simultaneously construct molecular nanowires at two or more positions. This substrate-independent nanoscale electrocrystallization process enables nanowires fabrication at specific positions using AC. We also succeeded in multiple fabrications only at each gap between the electrode tips. We found that π-stack was formed along the long axis of the nanowires obtained by analyzing the selected-area electron diffraction. We believe this technique has the potential for expansion to the novel low-cost and energy-saving fabrication of high-performance nanodevices

  18. A critique of current developments in simultaneous localization and mapping

    Directory of Open Access Journals (Sweden)

    Shoudong Huang

    2016-10-01

    Full Text Available The number of research publications dealing with the simultaneous localization and mapping problem has grown significantly over the past 15 years. Many fundamental and practical aspects of simultaneous localization and mapping have been addressed, and some efficient algorithms and practical solutions have been demonstrated. The aim of this paper is to provide a critical review of current theoretical understanding of the fundamental properties of the SLAM problem, such as observability, convergence, achievable accuracy and consistency. Recent research outcomes associated with these topics are briefly discussed together with potential future research directions.

  19. Server-Aided Two-Party Computation with Simultaneous Corruption

    DEFF Research Database (Denmark)

    Cascudo Pueyo, Ignacio; Damgård, Ivan Bjerre; Ranellucci, Samuel

    We consider secure two-party computation in the client-server model where there are two adversaries that operate separately but simultaneously, each of them corrupting one of the parties and a restricted subset of servers that they interact with. We model security via the local universal composab......We consider secure two-party computation in the client-server model where there are two adversaries that operate separately but simultaneously, each of them corrupting one of the parties and a restricted subset of servers that they interact with. We model security via the local universal...

  20. Simultaneous estimation of QTL effects and positions when using ...

    Indian Academy of Sciences (India)

    2015-03-04

    Mar 4, 2015 ... c Indian Academy of Sciences. RESEARCH ARTICLE. Simultaneous ... 1School of Mathematical Sciences, Heilongjiang University, Harbin 150080, People's Republic of China. 2School of Information ...... Kleinhofs A. 1996 Regions of the genome that affect agronomic performance in two-row barley.

  1. Simultaneous selection for yield and ratooning ability in sugarcane ...

    African Journals Online (AJOL)

    During sugarcane breeding, indirect selection for pest resistance and direct selection for high ratoon yields increases ratooning ability. The objective of this study was to describe the simultaneous screening of genotypes for yield and ratooning ability in sugarcane breeding trials using analysis of covariance. Data for cane ...

  2. Stability-indicating RP-HPLC method for simultaneous ...

    African Journals Online (AJOL)

    An accurate, simple and specific reverse phase LC procedure is established and validated for simultaneous estimation of methoxsalen and p-aminobenzoic acid in pharmaceutical formulated products and human serum. Chromatographic separation among methoxsalen, p-aminobenzoic acid and their degradation products ...

  3. A Simultaneous Study of Outsourcing and Location Choices

    DEFF Research Database (Denmark)

    Leiblein, Michael J.; Møller Larsen, Marcus; Pedersen, Torben

    This paper simultaneously evaluates factors affecting decisions regarding the organization and location of economic activity. The paper uses data from a comprehensive sample of exchanges involving public and private global semiconductor firms over the 1990 to 2005 time period. The paper accounts...

  4. A Simultaneous Examination of Outsourcing and Location Choices

    DEFF Research Database (Denmark)

    Leiblein, Michael J.; Larsen, Marcus M.; Pedersen, Torben

    2014-01-01

    This paper simultaneously evaluates factors affecting decisions regarding the organization and location of economic activity. The paper uses data from a comprehensive sample of exchanges involving public and private global semiconductor firms over the 1990 to 2005 time period. The paper accounts...

  5. Deactivation mechanism of the simultaneous removal of carbonyl ...

    Indian Academy of Sciences (India)

    KAI LI

    2017-11-10

    Nov 10, 2017 ... REGULAR ARTICLE. Deactivation mechanism of the simultaneous removal of carbonyl sulphide and carbon disulphide over Fe–Cu–Ni/MCSAC catalysts. KAI LIa, XIN SONGa, CHI WANGb, YI MEIb, XIN SUNa and PING NINGa,∗. aFaculty of Environmental Science and Engineering, Kunming University of ...

  6. SIMULTANEOUS PANCREAS-KIDNEY TRANSPLANTATION: EARLY POSTOPERATIVE COMPLICATIONS

    Directory of Open Access Journals (Sweden)

    M.Sh. Khubutia

    2014-01-01

    Full Text Available Aim: evaluation of the incidence of early postoperative complications after simultaneous pancreas-kidney transplantation.Materials and methods. The analysis of early postoperative complications after simultaneous pancreas-kidney transplantation is presented in the paper, the most rational diagnostic algorithms, non-surgical and surgical complications’ treatment; the outcomes of the SPKT are reported.Results. 15,6% of patients experienced surgical complications, 12,5% – immunological complications, 12,5% – infectious complications, 6,25% – complications of the immunosuppressive therapy. 1-year patient survival after SPKT was 91,4%; pancreas graft survival – 85,7%; kidney graft survival – 88,6%.Conclusion. The incidence of early postoperative complications after simultaneous pancreas-kidney transplantation remains signifi cant in spite of progressive improvement of simultaneous pancreas-kidney transplantation due to surgical technique improvement, introduction of new antibacterial and immunosuppressive agents. Data, we recovered, fully correspond to the data obtained from the global medical community.

  7. Simultaneous Determination of Flavonols and Terpene Lactones in ...

    African Journals Online (AJOL)

    (UPLC-TMS). Then the pharmacokinetics of these target compounds, of different preparations were studied. Results: The adjusted pharmacokinetic data showed that the ... Conclusion: The results indicate that UPLC-TMS can used to simultaneously evaluate the plasma .... T1/2, were calculated with the software program.

  8. Simultaneous Determination of Bisphenol A and Bisphenol S in ...

    African Journals Online (AJOL)

    NICO

    2014-08-08

    Aug 8, 2014 ... A simplified method based on ratio derivative ultraviolet spectrometry for simultaneous determination of bisphenol A (BPA) and bisphenol S (BPS) in environmental water is presented. The method provides a direct analysis of the samples without tedious sample preparation. In this method, the overlapping ...

  9. Observations of simultaneous upward lightning leaders from multiple tall structures

    Science.gov (United States)

    Warner, Tom A.

    2012-11-01

    We present high-speed camera observations (up to 7200 images per second) and correlated electric field measurements of upward lightning leaders initiated simultaneously from multiple tall towers. Four towers spanning a horizontal distance of 2.9 km and ranging in height from 121 to 191 m, developed upward leaders following a nearby positive cloud-to-ground (+ CG) flash on 7/16/09 UT in Rapid City, South Dakota, USA during the summer thunderstorm season. The optical and electric field observations suggest that all four upward propagating leaders were positive polarity (i.e., upward negative lightning) and initiated simultaneously approximately 2 ms following the + CG return stroke. There was significant intracloud flash activity prior to the return stroke, and upward leader initiation coincided with the passage of horizontally extensive in-cloud negative breakdown following the + CG return stroke. This observation supports the idea that downward positive cloud-to-ground lightning can trigger upward negative lightning from multiple tall objects. Specifically, the triggering component is an area of horizontally propagating negative breakdown following the + CG return stroke that influences a broad area resulting in simultaneous or near-simultaneous, positive polarity upward leader initiation from multiple tall objects.

  10. Evaluation of the simultaneous effects of a heat stabilized starter ...

    African Journals Online (AJOL)

    This study evaluates the simultaneous effect of dried starter concentration and fermentation duration on the quality characteristics of the African opaque sorghum beer using response surface methodology. The aim was to improve the beer quality and to optimize its fermentation process. Results show that the granule starter ...

  11. Simultaneous Multiagent Hyperpolarized 13C Perfusion Imaging

    DEFF Research Database (Denmark)

    von Morze, Cornelius; Bok, Robert A.; Reed, Galen D.

    2014-01-01

    Purpose: To demonstrate simultaneous hyperpolarization and imaging of three 13C-labeled perfusion MRI contrast agents with dissimilar molecular structures ([13C]urea, [13C]hydroxymethyl cyclopropane, and [13C]t-butanol) and correspondingly variable chemical shifts and physiological characteristic...

  12. Deactivation mechanism of the simultaneous removal of carbonyl ...

    Indian Academy of Sciences (India)

    KAI LI

    2017-11-10

    Nov 10, 2017 ... Our group has prepared a good cat- alyst (Fe–Cu–Ni/MCSAC) to simultaneously remove. COS and CS2; however, the corresponding deactiva- tion mechanism remains unknown. Determining the detailed steps of the deactivation mechanism is neces- sary because they can provide a theoretical foundation.

  13. Simultaneous resection of pulmonary tumor following cardiovascular surgery

    Directory of Open Access Journals (Sweden)

    Ryosuke Kaku

    2017-03-01

    Conclusion: The simultaneous resection of pulmonary tumor following cardiovascular surgery is safely performed, and is useful for the pathological diagnosis of the tumor. Further studies are warranted, however, this procedure may contribute to controlling the progression of lung cancer in patients with cardiovascular disease with comorbidities.

  14. Simultaneous Determination of Flavonols and Terpene Lactones in ...

    African Journals Online (AJOL)

    Purpose: To develop an ultra-performance liquid chromatography-tandem mass spectrometry (UPLCMS/MS) method for the simultaneous determination of 7 major components of Ginkgo leaf (kaempferol, quercetin, isorhamnetin, ginkgolides A, ginkgolides B, ginkgolides C and bilobalide) in dog plasma. Methods: Beagle ...

  15. Simultaneous versus incremental learning of multiple skills by modular robots

    NARCIS (Netherlands)

    Rossi, C.; Eiben, A.E.

    2014-01-01

    This paper is concerned with the problem of learning multiple skills by modular robots. The main question we address is whether it is better to learn multiple skills simultaneously (all-at-once) or incrementally (one-by-one). We conduct an experimental study with modular robots of various

  16. Multimodality calibration for simultaneous fluoroscopic and nuclear imaging

    NARCIS (Netherlands)

    Beijst, Casper; Elschot, Mattijs; van der Velden, Sanda; de Jong, Hugo W A M

    2016-01-01

    BACKGROUND: Simultaneous real-time fluoroscopic and nuclear imaging could benefit image-guided (oncological) procedures. To this end, a hybrid modality is currently being developed by our group, by combining a c-arm with a gamma camera and a four-pinhole collimator. Accurate determination of the

  17. Special Relativity in Week One: 4) Lack of Simultaneity

    Science.gov (United States)

    Huggins, Elisha

    2011-01-01

    This is our final article on teaching special relativity in the first week of an introductory physics course. One of the profound changes in our view of the world was Einstein's discovery of the lack of simultaneity. He illustrated this result with a thought experiment in which we observe a railroad car passing by us. We see the two ends of the…

  18. Simultaneous Communication and Cochlear Implants in the Classroom?

    Science.gov (United States)

    Blom, Helen C; Marschark, Marc

    2015-09-01

    This study was designed to evaluate the potential of simultaneous communication (sign and speech together) to support classroom learning by college students who use cochlear implants (CIs). Metacognitive awareness of learning also was evaluated. A within-subjects design involving 40 implant users indicated that the student participants learned significantly more when material was presented via simultaneous communication than spoken language overall, but a statistical interaction indicated that the difference held only with more difficult material. Learning in the speech-only condition was positively related to the students' spoken language skills, their confidence with spoken language, and their receptive simultaneous communication skills. Learning in that condition was negatively related to the age at which the participants learned to sign. Findings were interpreted to indicate that simultaneous communication can be beneficial for classroom learning by college students with CIs, at least with more complex material or when information redundancy is otherwise important. Further research is needed to determine who is likely to benefit in what settings.

  19. Simultaneous Communication and Cochlear Implants in the Classroom?

    NARCIS (Netherlands)

    Blom, H.C.; Marschark, M.

    2015-01-01

    This study was designed to evaluate the potential of simultaneous communication (sign and speech together) to support classroom learning by college students who use cochlear implants (CIs). Metacognitive awareness of learning also was evaluated. A within-subjects design involving 40 implant users

  20. Simultaneous stack-gas scrubbing and waste water treatment

    Science.gov (United States)

    Poradek, J. C.; Collins, D. D.

    1980-01-01

    Simultaneous treatment of wastewater and S02-laden stack gas make both treatments more efficient and economical. According to results of preliminary tests, solution generated by stack gas scrubbing cycle reduces bacterial content of wastewater. Both processess benefit by sharing concentrations of iron.

  1. Simultaneous Bilateral Transient Osteoporosis of the Hip without Pregnancy

    Directory of Open Access Journals (Sweden)

    Yasuaki Okada

    2016-01-01

    Full Text Available Transient osteoporosis of the hip (TOH is a rare disorder characterized by acute severe coxalgia and temporary osteopenia in the proximal femur. Although most cases were unilateral or staged bilateral TOH, some authors reported that the pregnant patients simultaneously had TOH in their bilateral hips. However, there has been no report of simultaneous bilateral TOH in the patient without pregnancy. A 25-year-old Japanese woman without pregnancy had acute simultaneous bilateral hip pain. Plain X-ray of the bilateral hips did not show a periarticular osteopenia. However, magnetic resonance image obtained one week after the onset demonstrated increased T2-weighted signal intensity and decreased T1-weighted signal intensity in the bilateral femoral heads. She was treated conservatively, and follow-up magnetic resonance image at seven weeks after the onset returned to normal bone marrow signal intensity. Her bilateral coxalgia subsided gradually. At one year after the onset, she had no sign of symptomatic flair. Our experience with this case indicates that recognizing the possibility of simultaneous bilateral TOH is important unless the patient is pregnant, and magnetic resonance image is predictable test to make a diagnosis of TOH, even in the absence of abnormal finding on plain X-ray.

  2. Simultaneous reconstruction and segmentation of CT scans with shadowed data

    DEFF Research Database (Denmark)

    Lauze, Francois Bernard; Quéau, Yvain; Plenge, Esben

    2017-01-01

    We propose a variational approach for simultaneous reconstruction and multiclass segmentation of X-ray CT images, with limited field of view and missing data. We propose a simple energy minimisation approach, loosely based on a Bayesian rationale. The resulting non convex problem is solved...

  3. Sequential and simultaneous revascularization in adult orthotopic piggyback liver transplantation

    NARCIS (Netherlands)

    Polak, WG; Miyamoto, S; Nemes, BA; Peeters, PMJG; de Jong, KP; Porte, RJ; Slooff, MJH

    The aim of the study was to assess whether there is a difference in outcome after sequential or simultaneous revascularization during orthotopic liver transplantation (OLT) in terms of patient and graft survival, mortality, morbidity, and liver function. The study population consisted of 102 adult

  4. Column Planarity and Partially-Simultaneous Geometric Embedding

    Czech Academy of Sciences Publication Activity Database

    Barba, L.; Evans, W.; Hoffmann, M.; Kusters, V.; Saumell, Maria; Speckmann, B.

    2017-01-01

    Roč. 21, č. 6 (2017), s. 983-1002 ISSN 1526-1719 Grant - others:GA MŠk(CZ) LO1506; GA MŠk(CZ) EE2.3.30.0038 Institutional support: RVO:67985807 Keywords : column planarity * unlabeled level planarity * simultaneous geometric embedding Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics

  5. Method for simultaneously coating a plurality of filaments

    Science.gov (United States)

    Miller, P.A.; Pochan, P.D.; Siegal, M.P.; Dominguez, F.

    1995-07-11

    Methods and apparatuses are disclosed for coating materials, and the products and compositions produced thereby. Substances, such as diamond or diamond-like carbon, are deposited onto materials, such as a filament or a plurality of filaments simultaneously, using one or more cylindrical, inductively coupled, resonator plasma reactors. 3 figs.

  6. Students' Preference of Method of Solving Simultaneous Equations ...

    African Journals Online (AJOL)

    The study focused on students' preference of two methods of solving simultaneous equations. The researcher adopted three research questions and three hypotheses. The research questions were answered using the descriptive statistics of percentages, while, the hypotheses were tested using the chi-square. The study ...

  7. Simultaneous multi-wavelength observations of GRS 1915+105

    DEFF Research Database (Denmark)

    Fuchs, Y.; Rodriguez, Cayo Juan Ramos; Mirabel, I.F.

    2003-01-01

    We present the result of multi-wavelength observations of the microquasar GRS 1915 + 105 in a plateau state with a luminosity of similar to7.5 x 10(38) erg s(-1) (similar to40% L-Edd), conducted simultaneously with the INTEGRAL and RXTE satellites, the ESOstarstar/NTT, the Ryle Telescope, the NRA...

  8. LIKELIHOOD ESTIMATION OF PARAMETERS USING SIMULTANEOUSLY MONITORED PROCESSES

    DEFF Research Database (Denmark)

    Friis-Hansen, Peter; Ditlevsen, Ove Dalager

    2004-01-01

    The topic is maximum likelihood inference from several simultaneously monitored response processes of a structure to obtain knowledge about the parameters of other not monitored but important response processes when the structure is subject to some Gaussian load field in space and time. The consi....... The considered example is a ship sailing with a given speed through a Gaussian wave field....

  9. Psoriasis in identical twins: simultaneous occurrence on same sites

    Directory of Open Access Journals (Sweden)

    Singh Sanjay

    1996-01-01

    Full Text Available A pair of 12-year-old identical male twins presented to us with dull erythematous plaques with coarse scaling and deep fissuring over soles of both feet starting simultaneously 18 months ago. The diagnosis of psoriasis was confirmed by histopathological examination of the biopsy specimen.

  10. Simultaneous test construction by zero-one programming

    NARCIS (Netherlands)

    Boekkooi-Timminga, Ellen

    1986-01-01

    A method is described for simultaneous test construction using the Operations Research technique zero-one programming. The model for zero-one programming consists of two parts. The first contains the objective function that describes the aspect to be optimized. The second part contains the

  11. Simultaneous extraction of chitin and astaxanthin from waste of ...

    African Journals Online (AJOL)

    This work investigates simple methods for simultaneous extraction of astaxanthin and chitin from industrial waste of the South African West Coast rock lobster Jasus lalandii. Removal of proteins from waste is the critical step to yield intact chitin and astaxanthin. Because common chemical methods destroy astaxanthin and ...

  12. Some effects of simultaneous administration of crude aqueous ...

    African Journals Online (AJOL)

    This study was designed to determine the simultaneous effect of Mangifera indica crude aqueous extract and the therapeutic dose of tetracycline on some hepatic enzymes (ALT and AST) and histology of the liver of adult wistar rats. 25 wistar rats were divided into 5 groups: Group A was untreated and served as control ...

  13. The First Simultaneous Microlensing Observations by Two Space telescopes

    DEFF Research Database (Denmark)

    Shvartzvald, Y.; Li, Z.; Udalski, A.

    2016-01-01

    Simultaneous observations of microlensing events from multiple locations allow for the breaking of degeneracies between the physical properties of the lensing system, specifically by exploring different regions of the lens plane and by directly measuring the “microlens parallax.” We report the di...

  14. Simultaneous radiodetermination of folate and vitamin B12

    International Nuclear Information System (INIS)

    Gutcho, S.; Mansbach, L.

    1978-01-01

    The invention concerns a method to simultaneously investigate or determine folate and vitamin B12. The differentiation between both compounds is based on the use of radioactive tracers; a radio-iodized folic acid is used as folate tracer; vitamin B12 can be labelled with 57 Co. (VJ) [de

  15. Simultaneous bilateral distal biceps tendon repair: case report

    Directory of Open Access Journals (Sweden)

    Thiago Medeiros Storti

    Full Text Available ABSTRACT Simultaneous bilateral rupture of the distal biceps tendon is a rare clinical entity, seldom reported in the literature and with unclear therapeutic setting. The authors report the case of a 39-year-old white man who suffered a simultaneous bilateral rupture while working out. When weightlifting with elbows at 90° of flexion, he suddenly felt pain on the anterior aspect of the arms, coming for evaluation after two days. He presented bulging contour of the biceps muscle belly and ecchymosis in the antecubital fossa, extending distally to the medial aspect of the forearm, as well as a marked decrease of supination strength and pain in active elbow flexion. MRI confirmed the rupture with retraction of the distal biceps bilaterally. The authors opted for performing the tendon repairs simultaneously through the double incision technique and fixation to the bicipital tuberosity with anchors. The patient progressed quite well, with full return to labor and sports activities, being satisfied with the result after two years of surgery. In the literature search, few reports of simultaneous bilateral rupture of the distal biceps were retrieved, with only one treated in the acute phase of injury. Therefore, the authors consider this procedure to be a good option to solve this complex condition.

  16. A simultaneous confidence band for sparse longitudinal regression

    KAUST Repository

    Ma, Shujie

    2012-01-01

    Functional data analysis has received considerable recent attention and a number of successful applications have been reported. In this paper, asymptotically simultaneous confidence bands are obtained for the mean function of the functional regression model, using piecewise constant spline estimation. Simulation experiments corroborate the asymptotic theory. The confidence band procedure is illustrated by analyzing CD4 cell counts of HIV infected patients.

  17. Simultaneously Recovering Rolling Stock Schedules and Depot Plans Under Disruption

    DEFF Research Database (Denmark)

    Haahr, Jørgen Thorlund; Lusby, Richard Martin; Larsen, Jesper

    2015-01-01

    In this paper we consider two important railway optimization problems. In particular, we focus on the Rolling Stock Rescheduling problem and the Depot Replanning problem, respectively. We present an integrated framework for solving these two problems simultaneously, and show that it is fast enoug...

  18. Simultaneous radiochemotherapy in cervical cancer: recommendations for chemotherapy

    International Nuclear Information System (INIS)

    Dunst, J.; Haensgen, G.

    2001-01-01

    Background: Simultaneous radiochemotherapy has recently been demonstrated to be superior to radiation alone in the treatment of cervical cancer. The objective of this article is to summarize the data of major randomized trials and to derive recommendations for daily clinical practice. Materials and Methods: We have analyzed the data from seven randomized trials in the recent literature in which radiotherapy alone as standard treatment has been compared to simultaneous radiochemotherapy. Four trials used cisplatin-based chemotherapy regimens, 5-FU, mitomycin C and epirubicin were used each in one trial. Results: All trials demonstrated some improvement in survival which was significant in the studies with cisplatin-based chemotherapy regimens. The survival benefit resulted mainly from an improvement in local control whereas chemotherapy had only a small and insignificant effect on distant metastases. Thus, the main action of chemotherapy is ''radiosensitization''. Cisplatin as single drug yielded comparable results as compared to combined regimens although the cisplatin dose was lower in the studies with combination chemotherapy. For the definitive treatment of locally advanced cancers, monotherapy with cisplatin can be recommended. Mitomycin C offers an attractive alternative to cisplatin in patients with contraindications for cisplatin. For postoperative radiochemotherapy, a combination of cisplatin/5-FU should be used because data with cisplatin alone are lacking so far. Simultaneous radiochemotherapy should also be considered for the curative treatment of local recurrences. Conclusions: The addition of simultaneous chemotherapy to radiotherapy is indicated in the vast majority of patients with cervical cancers who are treated with curative intent. (orig.) [de

  19. Simultaneous optimization of decisions using a linear utility function

    NARCIS (Netherlands)

    Vos, Hendrik J.

    1988-01-01

    The purpose of this paper is to simultaneously optimize decision rules for combinations of elementary decisions. As a result of this approach, rules are found that make more efficient use of the data than does optimizing those decisions separately. The framework for the approach is derived from

  20. Simultaneous inversion of the aftershock data of the 1993 Killari ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    The aftershock sequence of the September 30th, 1993 Killari earthquake in the Latur district of. Maharashtra state, India, recorded by 41 ... the nearest station to the epicenter. The NGRI location is shown in ... Keywords. Killari earthquake aftershocks; simultaneous inversion; stable continental region. Proc. Indian Acad. Sci.

  1. Fast simultaneous electrochemical detection of tetracycline and fluoxetine in water

    NARCIS (Netherlands)

    Ardelean, Magdalena; Pode, Rodica; Schoonman, J.; Pop, Aniela; Manea, Florica

    2017-01-01

    The electrochemical methods-based protocol for simultaneous detection of tetracycline (TC) from antibiotics class and fluoxetine (FXT) from anti-depressive pharmaceuticals class, which belongs to emerging pollutants from water, was developed in this study using carbon nanofiber-epoxy composite

  2. Simultaneous Determination of Metals in Coal with Low-Resolution ...

    African Journals Online (AJOL)

    The setup including low-resolution spectrometer with the charge-coupled device (CCD) detector, continuum radiation source and filter furnace (FF) atomizer was employed for direct simultaneous determination of Al, Fe, Mg, Cu and Mn in coal slurry. In the FF, sample vapour entered absorption volume by filtering through ...

  3. Simultaneous refinement of two components of an exsolution intergrowth

    DEFF Research Database (Denmark)

    Topa, Dan; Petricek, Vaclav; Dusek, Michal

    2008-01-01

    Crystal structures of intergrown lindstromite and krupkaite were determined in two distinct samples by a simultaneous crystal-structure refinement using a modified JANA program package. The exsolution intergrowths have a bulk composition, determined by means of electron microprobe, equal to bd(60...

  4. Simultaneous transport of water and solutes under transient ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science; Volume 117; Issue 4. Simultaneous transport of water and solutes under transient unsaturated flow conditions – A case study ... Keywords. Hydraulic conductivity; infiltration; leaching; Malaprabha; modeling; permeability; salinity; solute transport; SWIM model; water flow.

  5. Detection of three honeybee viruses simultaneously by a single ...

    African Journals Online (AJOL)

    A single multiplex reverse transcriptase (RT) polymerase chain reaction (PCR) assay was developed for the simultaneous detection of three honeybee viruses: acute bee paralysis virus (ABPV), sacbrood virus (SBV) and black queen cell virus (BQCV). Unique PCR primers were designed from the complete genome ...

  6. Simultaneous Determination of Bisphenol A and Bisphenol S in ...

    African Journals Online (AJOL)

    NICO

    2014-08-08

    Aug 8, 2014 ... Simultaneous Determination of Bisphenol A and. Bisphenol S in Environmental Water using Ratio Derivative. Ultraviolet Spectrometry. Guiping Cao*, Yafeng Zhuang and Baoliang Liu. Department of Chemical Engineering, Changzhou Institute of Technology, Changzhou, 213022, P.R. China. Received 18 ...

  7. Radioenzymatic simultaneous determination of epinephrine and norepinephrine in plasma

    International Nuclear Information System (INIS)

    Mueller, T.

    1978-01-01

    The high-pressure liquid chromatography (= HPLC) was used in simultaneous determinations of a few pg epinephrine and norepinephrine. This separation procedure improves the efficiency when compared with the conventional thin-layer chromatographic methods (TLC) and allows routine assays in plasma. (orig.) [de

  8. Simultaneous transport of water and solutes under transient ...

    Indian Academy of Sciences (India)

    Simultaneous transport of water and solutes under transient unsaturated flow conditions – A case study. B K Purandara. ∗. , N Varadarajan and B Venkatesh. National Institute of Hydrology, Hard Rock Regional Center, Belgaum 590 001, Karnataka, India. ∗ e-mail: purandarabk@yahoo.com. The imbalance between ...

  9. Simultaneous determination of warehouse layout and control policies

    NARCIS (Netherlands)

    Roodbergen, Kees Jan; Vis, Iris F. A.; Taylor, G. Don

    2015-01-01

    In a supply chain's order fulfilment process, it is often the warehouse that plays a central role in making the right product available to the right customer at the right time. This paper aims to improve warehouse performance by deriving an effective design method for the simultaneous determination

  10. Development of dual micro-PIV system for simultaneous velocity measurements: optical arrangement techniques and application to blood flow measurements

    International Nuclear Information System (INIS)

    Kvon, Alexandr; Lee, Yeon Ho; Cheema, Taqi Ahmad; Park, Cheol Woo

    2014-01-01

    Blood rheological characteristics can significantly vary with the motion of red blood cells (RBCs) in plasma. Moreover, RBCs show a complicated behavior in micro vessels. Thus, the determination of either plasma or blood cell velocity distribution has been the primary objective in blood flow analysis. However, the conditions during blood flow analyses are different from the actual physiological conditions, wherein the motion of the two distinct blood phases simultaneously occurs. In this study, we used an in vitro micro-particle image velocimetry, which is a reliable velocity field measurement technique, to evaluate the velocity distribution of plasma and blood cells simultaneously. Blood flow through a rectangular microchannel was determined using special optical filter arrangements and by assuming two different hematocrit values. Using the proposed technique, the averaged parabolic velocity profiles for the RBCs and plasma were successfully obtained and compared. The developed simultaneous measurement technique can be used to predict blood cell and plasma behaviors simultaneously with high accuracy under given clinical conditions. (paper)

  11. Evaluation of Linear Regression Simultaneous Myoelectric Control Using Intramuscular EMG.

    Science.gov (United States)

    Smith, Lauren H; Kuiken, Todd A; Hargrove, Levi J

    2016-04-01

    The objective of this study was to evaluate the ability of linear regression models to decode patterns of muscle coactivation from intramuscular electromyogram (EMG) and provide simultaneous myoelectric control of a virtual 3-DOF wrist/hand system. Performance was compared to the simultaneous control of conventional myoelectric prosthesis methods using intramuscular EMG (parallel dual-site control)-an approach that requires users to independently modulate individual muscles in the residual limb, which can be challenging for amputees. Linear regression control was evaluated in eight able-bodied subjects during a virtual Fitts' law task and was compared to performance of eight subjects using parallel dual-site control. An offline analysis also evaluated how different types of training data affected prediction accuracy of linear regression control. The two control systems demonstrated similar overall performance; however, the linear regression method demonstrated improved performance for targets requiring use of all three DOFs, whereas parallel dual-site control demonstrated improved performance for targets that required use of only one DOF. Subjects using linear regression control could more easily activate multiple DOFs simultaneously, but often experienced unintended movements when trying to isolate individual DOFs. Offline analyses also suggested that the method used to train linear regression systems may influence controllability. Linear regression myoelectric control using intramuscular EMG provided an alternative to parallel dual-site control for 3-DOF simultaneous control at the wrist and hand. The two methods demonstrated different strengths in controllability, highlighting the tradeoff between providing simultaneous control and the ability to isolate individual DOFs when desired.

  12. Simultaneous Occurrence of Malignant Fibrous Histiocytoma of the Ureter and Dioctophyma Renale Infection: A Case Report

    International Nuclear Information System (INIS)

    Park, Hye Young; Seo, Jung Wook; Lee, Byung Hoon; Lee, Ji Young; Kim, Su Young; Cha, Soon Joo; Kim, Yong Hoon; Hwang, Yoon Joon; Kim, You Sung

    2013-01-01

    A common soft-tissue tumor, malignant fibrous histiocytoma (MFH) occurs in mainly limbs, retroperitoneal and peritoneal space, and occurrence in kidneys or the ureter is very rare. Dioctophyma renale (D. renale) since first discovered in dog's kidney was found in the kidneys of animals such as mink, coyote and weasel, and human infection has only been reported in only approximately 20 cases worldwide. MFH of the ureter and D. renale infection very rarely occur in humans, and has not been reported in our country. Here, we described the case of an adult man in whom MFH of the ureter simultaneously occurred with D. renale infection. An initial CT scan showed a well-defined, persistent, enhancing polypoid mass-like lesion in the upper ureter. After 10 months, D. renale was excreted in the urine and a follow-up CT scan showed an increase in the size of that lesion and irregular thickening of the ureter wall. The diagnosis of MFH was pathologically verified.

  13. THE COMBINATION METHOD FOR DEPENDENT EVIDENCE AND ITS APPLICATION FOR SIMULTANEOUS FAULTS DIAGNOSIS

    OpenAIRE

    HAI-NA JIANG; XIAO-BIN XU; CHENG-LIN WEN

    2015-01-01

    This paper provides a method based on Dezert-Smarandache Theory (DSmT) for simultaneous faults diagnosis when evidence is dependent. Firstly, according to the characteristics of simultaneous faults, a frame of discernment is given for both single fault and simultaneous faults diagnosis, the DSmT combination rule applicable to simultaneous faults diagnosis is introduced.

  14. Simultaneous Observations of p-mode Light Walls and Magnetic Reconnection Ejections above Sunspot Light Bridges

    Energy Technology Data Exchange (ETDEWEB)

    Hou, Yijun; Zhang, Jun; Li, Ting; Yang, Shuhong; Li, Xiaohong, E-mail: yijunhou@nao.cas.cn, E-mail: zjun@nao.cas.cn [Key Laboratory of Solar Activity, National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 (China)

    2017-10-10

    Recent high-resolution observations from the Interface Region Imaging Spectrograph reveal bright wall-shaped structures in active regions (ARs), especially above sunspot light bridges. Their most prominent feature is the bright oscillating front in the 1400/1330 Å channel. These structures are named light walls and are often interpreted to be driven by p-mode waves. Above the light bridge of AR 12222 on 2014 December 06, we observed intermittent ejections superimposed on an oscillating light wall in the 1400 Å passband. At the base location of each ejection, the emission enhancement was detected in the Solar Dynamics Observatory 1600 Å channel. Thus, we suggest that in wall bases (light bridges), in addition to the leaked p-mode waves consistently driving the oscillating light wall, magnetic reconnection could happen intermittently at some locations and eject the heated plasma upward. Similarly, in the second event occurring in AR 12371 on 2015 June 16, a jet was simultaneously detected in addition to the light wall with a wave-shaped bright front above the light bridge. At the footpoint of this jet, lasting brightening was observed, implying magnetic reconnection at the base. We propose that in these events, two mechanisms, p-mode waves and magnetic reconnection, simultaneously play roles in the light bridge, and lead to the distinct kinetic features of the light walls and the ejection-like activities, respectively. To illustrate the two mechanisms and their resulting activities above light bridges, in this study we present a cartoon model.

  15. An analysis of heat removal during cryogen spray cooling and effects of simultaneous airflow application.

    Science.gov (United States)

    Torres, J H; Tunnell, J W; Pikkula, B M; Anvari, B

    2001-01-01

    Cryogen spray cooling (CSC) is a method used to protect the epidermis from non-specific thermal injury that may occur as a result of various dermatological laser procedures. However, better understanding of cryogen deposition and skin thermal response to CSC is needed to optimize the technique. Temperature measurements and video imaging were carried out on an epoxy phantom as well as human skin during CSC with and without simultaneous application of airflow which was intended to accelerate cryogen evaporation from the substrate surface. An inverse thermal conduction model was used to estimate heat flux and total heat removed. Lifetime of the cryogen film deposited on the surface of skin and epoxy phantom lasted several hundred milliseconds beyond the spurt, but could be reduced to the spurt duration by application of airflow. Values over 100 J/cm(3) were estimated for volumetric heat removed from the epidermis using CSC. "Film cooling" instead of "evaporative cooling" appears to be the dominant mode of CSC on skin. Estimated values of heat removed from the epidermis suggest that a cryogen spurt as long as 200 milliseconds is required to counteract heat generated by high laser fluences (e.g., in treatment of port wine stains) in patients with high concentration of epidermal melanin. Additional cooling beyond spurt termination can be avoided by simultaneous application of airflow, although it is unclear at the moment if avoiding the additional cooling would be beneficial in the actual clinical situation. Copyright 2001 Wiley-Liss, Inc.

  16. Simultaneous Blind Separation and Recognition of Speech Mixtures Using Two Microphones to Control a Robot Cleaner

    Directory of Open Access Journals (Sweden)

    Heungkyu Lee

    2013-02-01

    Full Text Available This paper proposes a method for the simultaneous separation and recognition of speech mixtures in noisy environments using two-channel based independent vector analysis (IVA on a home-robot cleaner. The issues to be considered in our target application are speech recognition at a distance and noise removal to cope with a variety of noises, including TV sounds, air conditioners, babble, and so on, that can occur in a house, where people can utter a voice command to control a robot cleaner at any time and at any location, even while a robot cleaner is moving. Thus, the system should always be in a recognition-ready state to promptly recognize a spoken word at any time, and the false acceptance rate should be lower. To cope with these issues, the keyword spotting technique is applied. In addition, a microphone alignment method and a model-based real-time IVA approach are proposed to effectively and simultaneously process the speech and noise sources, as well as to cover 360-degree directions irrespective of distance. From the experimental evaluations, we show that the proposed method is robust in terms of speech recognition accuracy, even when the speaker location is unfixed and changes all the time. In addition, the proposed method shows good performance in severely noisy environments.

  17. Simultaneous observations of Polar Mesosphere Summer Echoes at two different latitudes in Antarctica

    Directory of Open Access Journals (Sweden)

    H. Nilsson

    2008-11-01

    Full Text Available Simultaneous observations of Polar Mesosphere Summer Echoes (PMSE at Wasa and Davis in Antarctica have been compared. Data with simultaneous observations were obtained for 16 days between 18 January and 5 February 2007. Wasa is at a higher geographic latitude than Davis, but at lower geomagnetic latitude. PMSE strength and occurrence frequency were significantly higher at Wasa. The variation of daily PMSE occurrence over the measurement period was in agreement with temperature and frost-point estimates from the Microwave Limb Sounder on the Aura spacecraft for both Wasa and Davis. The diurnal variation of PMSE strength and occurrence frequency as well as the shape of the altitude profiles of average PMSE strength and occurrence frequency were similar for the two sites. The deepest part of the evening minimum in PMSE occurrence frequency occurred for the same magnetic local time at the two sites rather than for the same local solar time. The study indicates that PMSE strength and occurrence increase between 68.6° and 73° geographic latitude, consistent with observed differences in mesospheric temperatures and water vapor content. The average altitude distribution of PMSE varies relatively little with latitude in the same hemisphere.

  18. Simultaneous heat and moisture transfer in porous elements: transfer function method

    International Nuclear Information System (INIS)

    Souza, H.A. de.

    1985-01-01

    The presence of moisture in a porous element may strongly affect the transfer of heat through this element due to the processes which occur associated with the phase changes at the boundary surfaces and internally in the wall body. In addition, the structural properties of the element may also be meaningfully affected. The formulation of mathematical models for the simultaneous heat and mass transfer in porous elements results in a pair of nonlinear coupled equations for the temperature and moisture content distributions, in the material. It is supposed, in this work, that the actual variation of the properties of the porous medium is small in the range of variables which describe the specific problem to be analyzed. This enables us to work with linearized equations, making possible the use of linear solution methods. In this context, the present work deals with a linear procedure for the solution of simultaneous heat and moisture transfer problems in porous elements, sujected to arbitrary boundary conditions. This results in a linear relation between the heat and mass flux densities through the boundary surfaces of the elements and their associated potentials. It is shown that the model is consistent in asymptotical limiting cases; the model is then used for analyzing the drying process of a porous element, subjected to ambient actual conditions. (Author) [pt

  19. Co-occurring medical, psychiatric, and alcohol-related disorders among veterans returning from Iraq and Afghanistan.

    Science.gov (United States)

    Stecker, Tracy; Fortney, John; Owen, Richard; McGovern, Mark P; Williams, Silas

    2010-01-01

    Soldiers often return from war with a variety of combat-related mental health conditions, including posttraumatic stress disorder, depression, and substance-use disorders. The authors investigated common co-occurring medical and psychiatric conditions and patterns of conditions among returning Iraq/Afghanistan veterans using the Veterans Administration (VA) healthcare systems. Common clusters of ICD-9 diagnostic-related conditions among returning soldiers (N=293,861) were extracted from the VA data center. Diagnoses involving pain are extremely common among returning veterans seeking health care at the VA. In addition to pain-related conditions, psychiatric disorders rank second most prevalent. Psychiatric disorders, and in particular the multimorbid triad of pain, posttraumatic stress disorder, and depression frequently overlap. As more veterans return from war, there will be greater need for effective services. Given the findings of high rates of comorbidity and multimorbidity, VA services should be reorganized so as to co-locate psychiatric staff in pain centers, simultaneously targeting pain and psychiatric disorders.

  20. Hydrogeochemistry of co-occurring geogenic arsenic, fluoride and iodine in groundwater at Datong Basin, northern China.

    Science.gov (United States)

    Pi, Kunfu; Wang, Yanxin; Xie, Xianjun; Su, Chunli; Ma, Teng; Li, Junxia; Liu, Yaqing

    2015-12-30

    Abnormal levels of co-occurring arsenic (As), fluorine (F) and iodine (I) in groundwater at Datong Basin, northern China are geochemically unique. Hydrochemical, (18)O and (2)H characteristics of groundwater were analyzed to elucidate their mobilization processes. Aqueous As, F and I ranged from 5.6 to 2680 μg/L, 0.40 to 3.32 mg/L and 10.1 to 186 μg/L, respectively. High As, F and I groundwater was characterized by moderately alkaline, high HCO3(-), Fe(II), HS(-) and DOC concentrations with H3AsO3, F(-) and I(-) as the dominant species. The plots of δ(18)O values and Cl/Br ratios versus Cl(-) concentration demonstrate build-up of more oxidizing conditions and precipitation of carbonate minerals induced by vertical recharge and intensive evaporation facilitate As retention to Fe (hydr) oxides, but enhance F and I mobilization from host minerals. Under reducing conditions, As and I can be simultaneously released via reductive dissolution of Fe (hydr) oxides and reduction of As(V) and I(V) while F migration may be retarded due to effects of dissolution-precipitation equilibria between carbonate minerals and fluorite. With the prevalence of sulfate-reducing condition and lowering of HCO3(-) concentration, As and I may be sequestered by Fe(II) sulfides and F is retained to fluorite and on clay mineral surfaces. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Rules of co-occurring mutations characterize the antigenic evolution of human influenza A/H3N2, A/H1N1 and B viruses.

    Science.gov (United States)

    Chen, Haifen; Zhou, Xinrui; Zheng, Jie; Kwoh, Chee-Keong

    2016-12-05

    The human influenza viruses undergo rapid evolution (especially in hemagglutinin (HA), a glycoprotein on the surface of the virus), which enables the virus population to constantly evade the human immune system. Therefore, the vaccine has to be updated every year to stay effective. There is a need to characterize the evolution of influenza viruses for better selection of vaccine candidates and the prediction of pandemic strains. Studies have shown that the influenza hemagglutinin evolution is driven by the simultaneous mutations at antigenic sites. Here, we analyze simultaneous or co-occurring mutations in the HA protein of human influenza A/H3N2, A/H1N1 and B viruses to predict potential mutations, characterizing the antigenic evolution. We obtain the rules of mutation co-occurrence using association rule mining after extracting HA1 sequences and detect co-mutation sites under strong selective pressure. Then we predict the potential drifts with specific mutations of the viruses based on the rules and compare the results with the "observed" mutations in different years. The sites under frequent mutations are in antigenic regions (epitopes) or receptor binding sites. Our study demonstrates the co-occurring site mutations obtained by rule mining can capture the evolution of influenza viruses, and confirms that cooperative interactions among sites of HA1 protein drive the influenza antigenic evolution.

  2. Ethanol production from wet oxidized corn straw by simultaneous saccharification and fermentation

    DEFF Research Database (Denmark)

    Zhang, Q.; Yin, Y.; Thygesen, Anders

    2010-01-01

    remained in the solid fraction and recovery of cellulose was 95.87% after pretreatment. After 24 h hydrolysis at 50°C using cellulase, the achieved conversion of cellulose to glucose was about 67.6%. After 142 h of SSF with substrate concentration of 8%, ethanol yield of 79.0% of the theoretical......In order to find out the appropriate process for ethanol production from corn straw, alkaline wet-oxidation pretreatment (195°C, 15 min, Na2CO3 2 g/L, O2 1200 kPa) and simultaneous saccharification and fermentation (SSF) were adopted to produce ethanol. The results showed that 90% of cellulose...... was obtained. The estimated total ethanol production was 262.7 kg/t raw material by assuming the consumption of both C-6 and C-5. No obvious inhibition effect occurred during SSF. These offered experiment evidences for ethanol production from corn straw....

  3. The role of local framework luminance range in the simultaneous lightness contrast illusion with double increments

    Directory of Open Access Journals (Sweden)

    Economou Elias

    2015-01-01

    Full Text Available In double increment Simultaneous Lightness Contrast two equiluminant squares rest on darker backgrounds that differ in luminance. Research on such displays has produced conflicting results as to whether an illusion is observed. Anchoring theory of lightness predicts no illusion with double increment displays. Here we test the hypothesis that an illusion can be predicted if the framework containing the target and the darkest background carries more weight in lightness computations. We tested two displays, one with a general white and one with a general black background. An illusion was obtained only in the first display. These results suggest that an illusion can occur with double increment displays when the global value of the targets differs from their local value, as these conditions allow different local framework weighting to affect the targets’ final lightness. We propose that this parameter be added to the Anchoring Theory.

  4. Simultaneous and separate, low background counting of beta rays and gamma rays using the phoswich principle

    International Nuclear Information System (INIS)

    Mayhugh, M.R.; Utts, B.K.; Shoffner, B.M.

    1978-01-01

    A phoswich constructed using thin calcium fluoride optically coupled to a thicker sodium iodide crystal and operated with pulse shape analysis equipment can be used as an efficient low background counting assembly. Low background in the beta ray counting channel is achieved by judicious choice of pure materials in the assembly and by operating the analysis equipment so as to reject background events which occur simultaneously in the sodium iodide crystal. Careful survey of construction materials and methods has resulted in reducing beta ray counting background to 0.6 c/min for a 2-inch diameter assembly. The radioactivity of typical building materials will be discussed. A pulse shape analyzer has been constructed which provides separately adjusted time windows and separate output information for the beta ray and gamma ray channels. The dual channel capability combined with the low beta ray background reduces the sample counting time significantly for typical laboratory samples. (author)

  5. Simultaneous Ridge Augmentation and Accelerated Molar Uprighting for Implant Site Development: Two Case Reports with a Split-Mouth Design.

    Science.gov (United States)

    Wang, Chin-Wei; Chou, Michelle Yuching; Chen, Rebecca; Rowe, Todd; Masoud, Mohamed; Kim, David M; Intini, Giuseppe

    Well-coordinated interdisciplinary dental treatments provide the best esthetic, functional, and long-term results for patients. However, the length of such treatment, which may involve orthodontics, ridge augmentation, and dental implants, often deters patients from pursuing them. The two case reports presented here aim to present the advantage of simultaneous orthodontic molar uprighting and ridge augmentation procedures for future implant site development. Selective decortication of the alveolar bone, performed simultaneously with bone grafting, can accelerate the tooth uprighting process and synergistically reduce treatment duration. Two cases with bilaterally missing mandibular first molars were treated with this approach. In both patients, surgically accelerated uprighting of molars occurred 1.6 times faster than the contralateral site, where no surgery was performed. Additionally, ridge augmentation was successfully achieved with 2.5 to 5 mm of horizontal bone gain during the molar uprighting process.

  6. Motor-Sensory Recalibration Modulates Perceived Simultaneity of Cross-Modal Events at Different Distances

    Science.gov (United States)

    Parsons, Brent D.; Novich, Scott D.; Eagleman, David M.

    2013-01-01

    A popular model for the representation of time in the brain posits the existence of a single, central-clock. In that framework, temporal distortions in perception are explained by contracting or expanding time over a given interval. We here present evidence for an alternative account, one which proposes multiple independent timelines coexisting within the brain and stresses the importance of motor predictions and causal inferences in constructing our temporal representation of the world. Participants judged the simultaneity of a beep and flash coming from a single source at different distances. The beep was always presented at a constant delay after a motor action, while the flash occurred at a variable delay. Independent shifts in the implied timing of the auditory stimulus toward the motor action (but not the visual stimulus) provided evidence against a central-clock model. Additionally, the hypothesis that the time between action and delayed effect is compressed (known as intentional binding) seems unable to explain our results: firstly, because actions and effects can perceptually reverse, and secondly because the recalibration of simultaneity remains even after the participant’s intentional actions are no longer present. Contrary to previous reports, we also find that participants are unable to use distance cues to compensate for the relatively slower speed of sound when audio-visual events are presented in depth. When a motor act is used to control the distal event, however, adaptation to the delayed auditory signal occurs and subjective cross-sensory synchrony is maintained. These results support the hypothesis that perceptual timing derives from and is calibrated by our motor interactions with the world. PMID:23549660

  7. Motor-sensory recalibration modulates perceived simultaneity of cross-modal events atdifferent distances

    Directory of Open Access Journals (Sweden)

    Brent D Parsons

    2013-02-01

    Full Text Available A popular model for the representation of time in the brain posits the existence of a single, central clock. In that framework, temporal distortions in perception are explained by contracting or expanding time over a given interval. We here present evidence for an alternative account, one which proposes multiple independent timelines coexisting within the brain and stresses the importance of motor predictions and causal inferences in constructing our temporal representation of the world. Participants judged the simultaneity of a beep and flash coming from a single source at different distances. The beep was always presented at a constant delay after a motor action, while the flash occurred at a variable delay. Independent shifts in the implied timing of the auditory stimulus towards the motor action (but not the visual stimulus provided evidence against a central-clock model. Additionally, the hypothesis that the time between action and delayed effect is compressed (known as intentional binding seems unable to explain our results: firstly, because actions and effects can perceptually reverse, and secondly because the recalibration of simultaneity remains even after the participant’s intentional actions are no longer present. Contrary to previous reports, we also find that participants are unable to use distance cues to compensate for the relatively slower speed of sound when audio-visual events are presented in depth. When a motor act is used to control the distal event, however, adaptation to the delayed auditory signal occurs and subjective cross-sensory synchrony is maintained. These results support the hypothesis that perceptual timing derives from and is calibrated by our motor interactions with the world.

  8. Occurrence features of simultaneous H+- and He+-band EMIC emissions in the outer radiation belt

    Science.gov (United States)

    Fu, Song; He, Fengming; Gu, Xudong; Ni, Binbin; Xiang, Zheng; Liu, Jiang

    2018-04-01

    As an important loss mechanism of radiation belt electrons, electromagnetic ion cyclotron (EMIC) waves show up as three distinct frequency bands below the hydrogen (H+), helium (He+), and oxygen (O+) ion gyrofrequencies. Compared to O+-band EMIC waves, H+- and He+-band emissions generally occur more frequently and result in more efficient scattering removal of understanding the evolution of the relativistic electron population. To evaluate the occurrence pattern and wave properties of H+- and He+-band EMIC waves when they occur concurrently, we investigate 64 events of multi-band EMIC emissions identified from high quality Van Allen Probes wave data. Our quantitative results demonstrate a strong occurrence dependence of the multi-band EMIC emissions on magnetic local time (MLT) and L-shell to mainly concentrate on the dayside region of L = ∼4-6. We also find that the average magnetic field amplitude of H+-band waves is larger than that of He+-band waves only when L 2 nT He+-band amplitude, indicating that the He+-band waves can be more easily amplified than the H+-band waves under the same circumstances. For simultaneous occurrences of the two EMIC wave bands, their frequencies vary with L-shell and geomagnetic activity: the peak wave frequency of H+-band emissions varies between 0.25 and 0.8 fcp with the average between 0.25 and 0.6 fcp, while that of He+-band emissions varies between 0.03 and 0.23 fcp with the average between 0.05 and 0.15 fcp. These newly observed occurrence features of simultaneous H+- and He+-band EMIC emissions provide improved information to quantify the overall contribution of multi-band EMIC waves to the loss processes of radiation belt electrons.

  9. Ridge preservation after ridge expansion with simultaneous guided bone regeneration: a preclinical study.

    Science.gov (United States)

    Stricker, Andres; Fleiner, Jonathan; Stübinger, Stefan; Fleiner, Henrik; Buser, Daniel; Bosshardt, Dieter D

    2016-11-01

    To evaluate ridge preservation after ridge splitting with simultaneous implant placement and guided bone regeneration (GBR) in a miniature pig model. In miniature pigs, the mandibular premolars and first molars were extracted together with removal of the interdental and buccal bone. Three months later, ridge splitting and expansion of the buccal plate were performed with simultaneous placement of two titanium implants per quadrant. On the test side, access by a mucoperiosteal flap followed by GBR with a biphasic calcium phosphate and a collagen membrane was performed. On the contralateral control side, a mucosal flap (MF), leaving the periosteum attached to the buccal bone, was elevated. After healing periods of 6 and 12 weeks, eight and four animals, respectively, were sacrificed for histological and histometric evaluation. In the MF group, all 16 implants were osseointegrated, while in the GBR group, one bone fracture occurred, and six of 16 implants were lost. After 6 weeks, significantly higher bone crest levels were found for the GBR group than for the MF group both buccally and lingually (P bone thickness was greater in the GBR group than in the MF group (P bone was significantly higher in the GBR group compared to the MF group. Furthermore, buccal bone thickness in the GBR group was 0.93, 4.5, and 5.94 mm at, and 2 and 4 mm apical to the IS, respectively. The corresponding values in the MF group were greatly reduced (0, 0.21, and 2.56 mm). Bone loss on the buccal side compared to the lingual side was significantly greater only in the MF group. In this ridge expansion model in miniature pigs, the buccal bone volume was significantly better preserved with GBR when compared to a mucosal access flap, provided that soft tissue healing occurred complication free. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. Under one roof: A study of simultaneously managed hedge funds and funds of hedge funds

    OpenAIRE

    Agarwal, Vikas; Lu, Yan; Ray, Sugata

    2014-01-01

    We examine the simultaneous management of hedge funds and funds of hedge funds. Hedge fund firms can choose to simultaneously offer a fund of hedge funds. Similarly, fund of hedge fund firms can simultaneously offer a hedge fund. We find that while superior past performance and larger size drive the decision to become simultaneous for hedge fund firms, past flows drive the decision for funds of hedge fund firms. The effects of simultaneity are also different. When hedge fund firms start funds...

  11. Concommitant occurance of dens invaginatus and talon cusp: A case report

    OpenAIRE

    Yadav, Monica; S.M, Meghana; Kulkarni, Sandip R.

    2011-01-01

    PURPOSE: Morphological dental anomalies of the maxillary lateral incisors are relatively common. However, their simultaneous occurrence is a relatively rare event. We report a case of dens invaginatus and talon cusp concurrently affecting maxillary lateral incisors. The etiology, pathophysiology, association with other dental anomalies, as well as various treatment modalities of these anomalies are discussed. CASE DESCRIPTION: An 18-year-old male patient reported with a complaint of crowding ...

  12. Simultaneous measurement of radon and thoron using Lucas scintillation cell

    International Nuclear Information System (INIS)

    Eappen, K.P.; Nair, R.N.; Mayya, Y.S.

    2002-01-01

    A method has been developed for the simultaneous estimation of radon and thoron in a mixed environment using the Lucas Scintillation Cell (LSC). The method requires two arbitrary counting periods and corresponding total disintegrations. The basis of the method involves formulation of simultaneous linear equations with two unknown variables. The unknown variables represent the radon and thoron activities in the cell. The coefficients of the equations are the integrated activities of radon, thoron and their alpha decay products per unit activities of the parent radionuclides. The method can be used to estimate the radon and thoron concentrations in a mixed environment accurately and quickly, as there is no need to delay the counting to achieve complete decay of thoron. The mathematical basis of the method along with few experimental results is presented in this paper. Results yielded, on comparison, good agreement with the Delay Count Method and Double Filter Sampling Technique. (author)

  13. Quadratic grating apodized photon sieves for simultaneous multiplane microscopy

    Science.gov (United States)

    Cheng, Yiguang; Zhu, Jiangping; He, Yu; Tang, Yan; Hu, Song; Zhao, Lixin

    2017-10-01

    We present a new type of imaging device, named quadratic grating apodized photon sieve (QGPS), used as the objective for simultaneous multiplane imaging in X-rays. The proposed QGPS is structured based on the combination of two concepts: photon sieves and quadratic gratings. Its design principles are also expounded in detail. Analysis of imaging properties of QGPS in terms of point-spread function shows that QGPS can image multiple layers within an object field onto a single image plane. Simulated and experimental results in visible light both demonstrate the feasibility of QGPS for simultaneous multiplane imaging, which is extremely promising to detect dynamic specimens by X-ray microscopy in the physical and life sciences.

  14. Variation among heritage speakers: Sequential vs. simultaneous bilinguals

    Directory of Open Access Journals (Sweden)

    Teresa Lee

    2013-08-01

    Full Text Available This study examines the differences in the grammatical knowledge of two types of heritage speakers of Korean. Early simultaneous bilinguals are exposed to both English and the heritage language from birth, whereas early sequential bilinguals are exposed to the heritage language first and then to English upon schooling. A listening comprehension task involving relative clauses was conducted with 51 beginning-level Korean heritage speakers. The results showed that the early sequential bilinguals exhibited much more accurate knowledge than the early simultaneous bilinguals, who lacked rudimentary knowledge of Korean relative clauses. Drawing on the findings of adult and child Korean L1 data on the acquisition of relative clauses, the performance of each group is discussed with respect to attrition and incomplete acquisition of the heritage language.

  15. Simultaneous angular alignment of segmented mirrors using sinusoidal pattern analysis

    Science.gov (United States)

    Choi, Heejoo; Trumper, Isaac; Dubin, Matthew; Zhao, Wenchuan; Kim, Dae Wook

    2017-08-01

    A segmented mirror is one of the most promising solutions to build an extremely large aperture telescope to reveal the secrets of the universe. In this manuscript, we present a simultaneous angle alignment method for segmented mirrors. By taking the displayed sinusoidal pattern reflecting off the mirrors, the tip-tilt angles are measured with 0.8 μrad resolution for a flat mirror. Due to the efficient calculation using Fourier analysis, the total measurement time for seven flat mirrors is 0.07 s. In addition, a multiplexed sinusoidal pattern is adapted to resolve the intrinsic 2π ambiguity problem in a sinusoidal signal. The presented method can measure any number of segmented mirrors provided that the camera's field of view can cover them all simultaneously.

  16. Organized simultaneous displays facilitate learning of complex natural science categories.

    Science.gov (United States)

    Meagher, Brian J; Carvalho, Paulo F; Goldstone, Robert L; Nosofsky, Robert M

    2017-12-01

    Subjects learned to classify images of rocks into the categories igneous, metamorphic, and sedimentary. In accord with the real-world structure of these categories, the to-be-classified rocks in the experiments had a dispersed similarity structure. Our central hypothesis was that learning of these complex categories would be improved through observational study of organized, simultaneous displays of the multiple rock tokens. In support of this hypothesis, a technique that included the presentation of the simultaneous displays during phases of the learning process yielded improved acquisition (Experiment 1) and generalization (Experiment 2) compared to methods that relied solely on sequential forms of study and testing. The technique appears to provide a good starting point for application of cognitive-psychology principles of effective category learning to the science classroom.

  17. Simultaneous spectrophotometric estimation of haloperidol and trihexyphenidyl in tablets.

    Science.gov (United States)

    Wate, S P; Borkar, A A

    2010-03-01

    The combination of haloperidol and trihexyphenidyl is a dosage form to be used as antidyskinetic agent. Literature revealed that there is no single method for the simultaneous estimation of these drugs in tablet dosage form, which prompted us to develop a simple, rapid, accurate, economical and sensitive spectrophotometric method. The simultaneous estimation method is based on the principle of additivity of absorbance, for the determination of haloperidol and trihexyphenidyl in tablet formulation. The absorption maxima of the drugs were found to be at 245.0 nm and 206.0 nm respectively for haloperidol and trihexyphenidyl in methanol and 0.1N HCl (90:10). The obeyance of Beer Lambert's law was observed in the concentration range of 2.5-12.5 µg/ml for haloperidol and 1.0-5.0 µg/ml for trihexyphenidyl. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies.

  18. Simultaneous thermal neutron decay time and porosity logging system

    International Nuclear Information System (INIS)

    Smith, H.D. Jr.; Smith, M.P.; Schultz, W.E.

    1979-01-01

    A simultaneous pulsed neutron porosity and thermal neutron capture cross section logging system is provided for radiological well logging of subsurface earth formations. A logging tool provided with a 14 MeV pulsed neutron source, an epithermal neutron detector, and a combination gamma ray and fast neutron detector is moved through a borehole. Repetitive bursts of neutrons irradiate the earth formations; and, during the bursts, the fast neutron and epithermal neutron populations are sampled. During the interval between bursts the thermal neutron capture gamma ray population is sampled in two or more time intervals. The fast and epithermal neutron population measurements are combined to provide a measurement of formation porosity phi. The capture gamma ray measurements are combined to provide a simultaneous determination of the thermal neutron capture cross section Σ

  19. Simultaneity in Minkowski Spacetime: From Uniqueness to Arbitrariness

    Science.gov (United States)

    Besnard, Fabien

    2012-09-01

    Malament (Noûs 11:293-300, 1977) proved a certain uniqueness theorem about standard synchrony, also known as Poincaré-Einstein simultaneity, which has generated many commentaries over the years, some of them contradictory. We think that the situation called for some clarification. After reviewing and discussing some of the literature involved, we prove two results which, hopefully, will help clarifying this debate by filling the gap between the uniquess of Malament's theorem, which allows the observer to use very few tools, and the complete arbitrariness of a time coordinate in full-fledged Relativity theory. In the spirit of Malament's theorem, and in opposition to most of its commentators, we emphasize explicit definability of simultaneity relations, and give only constructive proofs. We also explore what happens when we reduce to "purely local" data with respect to an observer.

  20. Greedy Algorithms for Nonnegativity-Constrained Simultaneous Sparse Recovery

    Science.gov (United States)

    Kim, Daeun; Haldar, Justin P.

    2016-01-01

    This work proposes a family of greedy algorithms to jointly reconstruct a set of vectors that are (i) nonnegative and (ii) simultaneously sparse with a shared support set. The proposed algorithms generalize previous approaches that were designed to impose these constraints individually. Similar to previous greedy algorithms for sparse recovery, the proposed algorithms iteratively identify promising support indices. In contrast to previous approaches, the support index selection procedure has been adapted to prioritize indices that are consistent with both the nonnegativity and shared support constraints. Empirical results demonstrate for the first time that the combined use of simultaneous sparsity and nonnegativity constraints can substantially improve recovery performance relative to existing greedy algorithms that impose less signal structure. PMID:26973368

  1. Acoustic Communications Considerations for Collaborative Simultaneous Localization and Mapping

    Science.gov (United States)

    2014-12-01

    COLLABORATIVE SIMULTANEOUS LOCALIZATION AND MAPPING 6. AUTHOR(S) Ryan Peter Hilger 7. PERFORMING ORGANIZATION NA:i\\ IIE (S) AND ADDRESS(ES) Naval Postgraduate...values converge or begin to show convergence to the predicted analytical solutions for the rms average of a sawtooth wave...possible solution to denying the United States access to a region without the need to be able to conventionally confront maritime forces in Mahanian naval

  2. Simultaneous dual-species matter-wave accelerometer

    Science.gov (United States)

    Bidel, Yannick; Bresson, Alexandre; Zahzam, Nassim; Bonnin, Alexis

    Light pulse atom interferometers have proven to be very high performance sensors with the development in recent decades of cold atom gravimeters, gravity gradiometers, and gyroscopes. These sensors seem very promising for spatial applications like gravity field mapping, detecting gravitational waves or testing the weak equivalence principle (WEP). In the context of testing the WEP, some projects under development (QWEP, STE-QUEST, ICE, QUANTUS) aim to measure the acceleration of two different atomic species. To date, a single-atom-based ground test of the WEP was carried out by alternatively handling both isotopes of rubidium. This method, providing a non simultaneous differential measurement, exhibits a sensitivity limited by vibration noise. Special attention must thus be paid to develop atom interferometers which will simultaneously interrogate two different atomic species in order to take full advantage of a differential measurement and to achieve the targeted sensitivity and accuracy. In this paper, we report the realization of a matter-wave interferometer based on Raman transitions which simultaneously interrogates two different atomic species ((87) Rb and (85) Rb). The simultaneous aspect of our experiment presents encouraging preliminary results for future dual-species atom interferometry projects and seems very promising by taking advantage of a differential acceleration measurement. Indeed, the resolution of our differential accelerometer remains lower than 3.9 × 10(-8) g even with vibration levels up to 1 × 10(-3) g thanks to common-mode vibration noise rejection. An atom-based test of the weak equivalence principle has also been carried out leading to a differential free fall measurement between both isotopes of Delta g/g = (1.2 ± 3.2) × 10(-7) .

  3. Simultaneous radioassay of folate and vitamin B12

    International Nuclear Information System (INIS)

    1981-01-01

    An improved simultaneous radioassay for folate and vitamin B 12 in biological specimens is described. A sample containing folate and vitamin B 12 is contacted with 125 I-folate and 57 Co-vitamin B 12 and their respective specific binders. After separation of the bound and free portions, the radioactivity in the portions is counted and the amounts of folate and vitamin B 12 then determined from standard curves. (U.K.)

  4. Simultaneous optical/gamma-ray observations of GRBs

    Science.gov (United States)

    Greiner, J.; Wenzel, W.; Hudec, R.; Moskalenko, E. I.; Metlov, V.; Chernych, N. S.; Getman, V. S.; Ziener, Rainer; Birkle, K.; Bade, N.

    1994-01-01

    Details on the project to search for serendipitous time correlated optical photographic observations of Gamma Ray Bursters (GRB's) are presented. The ongoing photographic observations at nine observatories are used to look for plates which were exposed simultaneously with a gamma ray burst detected by the gamma ray instrument team (BATSE) and contain the burst position. The results for the first two years of the gamma ray instrument team operation are presented.

  5. Simultaneity in Minkowski spacetime: from uniqueness to arbitrariness

    OpenAIRE

    Besnard, Fabien

    2011-01-01

    In 1977, Malament proved a certain uniqueness theorem about standard synchrony, also known as Poincar\\'e-Einstein simultaneity, which has generated many commentaries over the years, some of them contradictory. We think that the situation called for some cleaning up. After reviewing and discussing some of the literature involved, we prove two results which, hopefully, will help clarifying this debate by filling the gap between the uniquess of Malament's theorem, which allows the observer to us...

  6. Motion detection using near-simultaneous satellite acquisitions

    OpenAIRE

    Kääb, Andreas; Leprince, Sébastien

    2014-01-01

    A number of acquisition constellations for airborne or spaceborne optical images involve small time-lags and produce near-simultaneous images, a type of data which has thus far been little exploited to detect or quantify target motion at the Earth’s surface. These time-lag constellations were for the most part not even meant to exhibit motion tracking capabilities, or these capabilities were considered a drawback. In this contribution, we give the first systematic overview of the methods and ...

  7. Simultaneous two-photon excitation of photodynamic therapy agents

    Energy Technology Data Exchange (ETDEWEB)

    Wachter, E.A.; Fisher, W.G. [Oak Ridge National Lab., TN (United States)]|[Photogen, Inc., Knoxville, TN (United States); Partridge, W.P. [Oak Ridge National Lab., TN (United States); Dees, H.C. [Photogen, Inc., Knoxville, TN (United States); Petersen, M.G. [Univ. of Tennessee, Knoxville, TN (United States). College of Veterinary Medicine

    1998-01-01

    The spectroscopic and photochemical properties of several photosensitive compounds are compared using conventional single-photon excitation (SPE) and simultaneous two-photon excitation (TPE). TPE is achieved using a mode-locked titanium:sapphire laser, the near infrared output of which allows direct promotion of non-resonant TPE. Excitation spectra and excited state properties of both type 1 and type 2 photodynamic therapy (PDT) agents are examined.

  8. Efficacy of Bilateral Simultaneous Hallux Valgus Correction Compared to Unilateral.

    Science.gov (United States)

    Boychenko, Anton Viktorovich; Solomin, Leonid Nikolaevich; Parfeyev, Sergey Gennadievich; Obukhov, Ilya Esatovich; Belokrylova, Maria Sergeevna; Davidov, Denis Vladimirovich

    2015-11-01

    Hallux valgus affects up to 29% of adults and can be bilateral in 84% of cases. Contemporary surgical techniques provide the possibility of simultaneous bilateral correction, but still there is no consensus on whether staged or simultaneous correction should be performed if both feet are involved. The aim of the present study was to report our experience of treatment of patients with hallux valgus and to perform comparative analysis of results obtained from unilateral and simultaneous bilateral surgical correction. Data on 60 feet (40 patients) with hallux valgus that underwent surgery between 2010 and 2013 using scarf osteotomy and lateral soft tissue release were analyzed. Unilateral correction was performed in 30 feet (25 patients) and bilateral correction in 30 feet (15 patients). The patients from both groups were admitted to hospital for 7 days. Functional assessment (American Orthopaedic Foot & Ankle Society [AOFAS] score) and radiographic examination (intermetatarsal and hallux valgus angles) were performed preoperatively and at 6, 12, and 24 months after the procedure. Comparative analysis between groups with bilateral and unilateral correction was carried out. At 24 months after surgery in the bilateral and unilateral groups, the mean AOFAS score was 86 ± 6.2 and 86 ± 6.9 (P > .05), the mean intermetatarsal angle was 8.4 ± 0.5 and 8.8 ± 0.8 degrees (P > .05), and the mean metatarsophalangeal angle was 13.0 ± 1.2 and 13.0 ± 0.9 degrees (P > .05), respectively. According to the data obtained, simultaneous bilateral correction had the same functional and radiographic results as unilateral surgery. Level III, case series. © The Author(s) 2015.

  9. Determination of phenols using simultaneous steam distillation-extraction.

    Science.gov (United States)

    Barták, P; Frnková, P; Cáp, L

    2000-01-21

    Simultaneous distillation-extraction was proposed as a preconcentration step for the determination of phenol and its derivatives in aqueous and soil samples. Detection limits of 0.01 mg l(-1) (water) and 0.1 mg kg(-1) (soil) were achieved by gas chromatography-flame ionization detection. The described preconcentration procedure was applied for the primary study of the adsorption equilibrium in a water-soil system serving as a model of phenol behaviors in the environment.

  10. Simultaneous confidence bands for Cox regression from semiparametric random censorship.

    Science.gov (United States)

    Mondal, Shoubhik; Subramanian, Sundarraman

    2016-01-01

    Cox regression is combined with semiparametric random censorship models to construct simultaneous confidence bands (SCBs) for subject-specific survival curves. Simulation results are presented to compare the performance of the proposed SCBs with the SCBs that are based only on standard Cox. The new SCBs provide correct empirical coverage and are more informative. The proposed SCBs are illustrated with two real examples. An extension to handle missing censoring indicators is also outlined.

  11. Simultaneous estimation of atorvastatin calcium and amlodipine besylate from tablets

    OpenAIRE

    Mishra P; Gupta Alka; Shah K

    2007-01-01

    The present communication deals with the development of a new, simple, specific, sensitive, rapid and economical procedure for simultaneous estimation of atorvastatin calcium and amlodipine besylate in a combined dosage form. The method is based on the native ultraviolet absorbance maxima of the two chemotherapeutic agents. As both compounds do not interact chemically in methanol, two wavelengths 246 nm for atorvastatin calcium and 360 nm for amlodipine besylate were used. Both the drugs obey...

  12. Simultaneous control of blood glucose, blood pressure, and lipid ...

    African Journals Online (AJOL)

    2016-01-21

    Jan 21, 2016 ... A questionnaire was used to collect basic information and blood samples were drawn for laboratory measurements. Simultaneous control was defined as HbA1c <7%, BP <130/80 mmHg, and LDL‑C <2.6 mmol/L. Results: A total of 2274 individuals were included, of which 588 individuals (25.9%) achieved ...

  13. Striatal and Hippocampal Entropy and Recognition Signals in Category Learning: Simultaneous Processes Revealed by Model-Based fMRI

    Science.gov (United States)

    Davis, Tyler; Love, Bradley C.; Preston, Alison R.

    2012-01-01

    Category learning is a complex phenomenon that engages multiple cognitive processes, many of which occur simultaneously and unfold dynamically over time. For example, as people encounter objects in the world, they simultaneously engage processes to determine their fit with current knowledge structures, gather new information about the objects, and adjust their representations to support behavior in future encounters. Many techniques that are available to understand the neural basis of category learning assume that the multiple processes that subserve it can be neatly separated between different trials of an experiment. Model-based functional magnetic resonance imaging offers a promising tool to separate multiple, simultaneously occurring processes and bring the analysis of neuroimaging data more in line with category learning’s dynamic and multifaceted nature. We use model-based imaging to explore the neural basis of recognition and entropy signals in the medial temporal lobe and striatum that are engaged while participants learn to categorize novel stimuli. Consistent with theories suggesting a role for the anterior hippocampus and ventral striatum in motivated learning in response to uncertainty, we find that activation in both regions correlates with a model-based measure of entropy. Simultaneously, separate subregions of the hippocampus and striatum exhibit activation correlated with a model-based recognition strength measure. Our results suggest that model-based analyses are exceptionally useful for extracting information about cognitive processes from neuroimaging data. Models provide a basis for identifying the multiple neural processes that contribute to behavior, and neuroimaging data can provide a powerful test bed for constraining and testing model predictions. PMID:22746951

  14. Simultaneous use of alcohol with methamphetamine but not ecstasy linked with aggression among young adult stimulant users.

    Science.gov (United States)

    Leslie, Ellen M; Smirnov, Andrew; Cherney, Adrian; Wells, Helene; Legosz, Margot; Kemp, Robert; Najman, Jake M

    2017-07-01

    Illicit stimulants are often combined with alcohol in nightlife entertainment districts, an environment where aggressive behaviour commonly occurs. While alcohol and methamphetamine use are each associated with aggressive behaviour, relatively little is known about the impact of the combined use of alcohol and amphetamine-type stimulants (i.e., ecstasy [MDMA] and methamphetamine) on aggression. Analysis of longitudinal data from a population-based sample of Australian young adult amphetamine-type stimulant users (n=248) to examine: (a) prevalence and timing of simultaneous alcohol and amphetamine-type stimulant use and (b) predictors of ecstasy- and methamphetamine-related aggression and hostility. Prediction models of ecstasy- and methamphetamine-related aggression and hostility were developed using multivariate logistic regression. Simultaneous alcohol consumption and amphetamine-type stimulant use was prevalent, with drinking generally occurring before consuming amphetamine-type stimulants and while 'high'. Methamphetamine-related aggression and hostility was significantly associated with recurrent risky simultaneous methamphetamine and alcohol use (Adjusted Odds Ratio [AOR] 2.74, 95% CI 1.09-6.89), a high frequency and increasing use methamphetamine trajectory (AOR 7.23, 95% CI 1.27-41.03), and high trait aggression (AOR 5.78, 95% CI 2.53-13.20). In contrast, only trait aggression (moderate: AOR 3.01, 95% CI 1.55-5.84; high: AOR 5.02, 95% CI 2.38-10.61) was associated with ecstasy-related aggression and hostility. These findings indicate a link between risky patterns of simultaneous alcohol and methamphetamine use and methamphetamine-related aggression and hostility, independent of separate use of alcohol, methamphetamine and cannabis, trait aggression, psychosis, and gender. The policy challenges of amphetamine-type stimulant and alcohol use require a targeted, multidisciplinary approach. Copyright © 2017 Elsevier Ltd. All rights reserved.

  15. Simultaneous resection for colorectal cancer with synchronous liver metastases is a safe procedure: Outcomes at a single center in Turkey.

    Science.gov (United States)

    Dulundu, Ender; Attaallah, Wafi; Tilki, Metin; Yegen, Cumhur; Coskun, Safak; Coskun, Mumin; Erdim, Aylin; Tanrikulu, Eda; Yardimci, Samet; Gunal, Omer

    2017-05-23

    The optimal surgical strategy for treating colorectal cancer with synchronous liver metastases is subject to debate. The current study sought to evaluate the outcomes of simultaneous colorectal cancer and liver metastases resection in a single center. Prospectively collected data on all patients with synchronous colorectal liver metastases who underwent simultaneous resection with curative intent were analyzed retrospectively. Patient outcomes were compared depending on the primary tumor location and type of liver resection (major or minor). Between January 2005 and August 2016, 108 patients underwent simultaneous resection of primary colorectal cancer and liver metastases. The tumor was localized to the right side of the colon in 24 patients (22%), to the left side in 40 (37%), and to the rectum in 44 (41%). Perioperative mortality occurred in 3 patients (3%). Postoperative complications were noted in 32 patients (30%), and most of these complications (75%) were grade 1 to 3 according to the Clavien-Dindo classification. Neither perioperative mortality nor the rate of postoperative complications after simultaneous resection differed among patients with cancer of the right side of the colon, those with cancer of the left side of the colon, and those with rectal cancer (4%, 2.5%, and 2%, respectively, p = 0.89) and (17%, 33%, and 34%, respectively; p = 0.29)]. The 5-year overall survival of the entire sample was 54% and the 3-year overall survival was 67 %. In conclusion, simultaneous resection for primary colorectal cancer and liver metastases is a safe procedure and can be performed without excess morbidity in carefully selected patients regardless of the location of the primary tumor and type of hepatectomy.

  16. Use of an improved simultaneous tomography cassette in linear tomography

    International Nuclear Information System (INIS)

    Egender, G.; Pirker, E.; Gornik, E.; Innsbruck Univ.

    1984-01-01

    An improved simultaneous tomography cassette according to P. Landau was tried out for four months using four tomographs in routine work. The mode of operation is based on accurate control of the relative speeds of the individual x-ray films resulting in simultaneous imaging of 6 equidistant tomographic levels. Clinical testing was effected in 80 cases: nephrotomography, of the lungs, the hilum, and the skeleton. In particular, the article describes imaging of the renal arteries by simultaneous tomography for the purpose of finding out the cause of hypertension, and if there is suspicion of a space-occupying growth in the kidney, basing on the urogram. The specific advantages of this technique are, on the one hand, improved diagnostic efficiency (the tomograms are taken during the same respiratory phase, more rapid diagnosis especially with accident patients), and, on the other hand, an important reduction in the x-ray exposure of the patient; furthermore, the life of the x-ray tube is prolonged, and there is a definite saving of time for both patient and personnel, the image quality being comparable with that of single-layer tomography. (orig.) [de

  17. Simultaneous transcriptional profiling of bacteria and their host cells.

    Directory of Open Access Journals (Sweden)

    Michael S Humphrys

    Full Text Available We developed an RNA-Seq-based method to simultaneously capture prokaryotic and eukaryotic expression profiles of cells infected with intracellular bacteria. As proof of principle, this method was applied to Chlamydia trachomatis-infected epithelial cell monolayers in vitro, successfully obtaining transcriptomes of both C. trachomatis and the host cells at 1 and 24 hours post-infection. Chlamydiae are obligate intracellular bacterial pathogens that cause a range of mammalian diseases. In humans chlamydiae are responsible for the most common sexually transmitted bacterial infections and trachoma (infectious blindness. Disease arises by adverse host inflammatory reactions that induce tissue damage & scarring. However, little is known about the mechanisms underlying these outcomes. Chlamydia are genetically intractable as replication outside of the host cell is not yet possible and there are no practical tools for routine genetic manipulation, making genome-scale approaches critical. The early timeframe of infection is poorly understood and the host transcriptional response to chlamydial infection is not well defined. Our simultaneous RNA-Seq method was applied to a simplified in vitro model of chlamydial infection. We discovered a possible chlamydial strategy for early iron acquisition, putative immune dampening effects of chlamydial infection on the host cell, and present a hypothesis for Chlamydia-induced fibrotic scarring through runaway positive feedback loops. In general, simultaneous RNA-Seq helps to reveal the complex interplay between invading bacterial pathogens and their host mammalian cells and is immediately applicable to any bacteria/host cell interaction.

  18. Anatomy of simultaneous flood peaks at a lowland confluence

    Science.gov (United States)

    Hoitink, T.; Geertsema, T.; Teuling, R.; Uijlenhoet, R.; Torfs, P. J.; Weerts, A.

    2017-12-01

    Lowlands are vulnerable to flooding due to their mild topography in often densely populated areas with high social and economic value. Moreover, multiple physical processes coincide in lowland areas, such as those involved in river-sea interactions and in merging of rivers. Simultaneous occurrence of such processes can result in amplifying or attenuating effects on water levels. Our aim is to understand the mechanisms behind simultaneous occurrence of discharge waves in a river and its lowland tributaries, taking the confluence of the Meuse river with the joining tributaries of the Dommel and Aa as an example. Especially since the January 1995 flood at this confluence is the result of the simultaneous occurrence of discharge peaks in the main stream and the tributaries. Here, we introduce a new way of analyzing lowland discharge and water level dynamics, by tracing individual flood waves based on dynamic time warping. The analysis shows that the exact timing of the arrival of discharge peaks is little relevant, because of the long duration of a discharge wave compared to the time lags between peaks. The discharge waves last on average 9 days, whereas the typical lag time between discharge peaks in the main river and the tributaries is 3 days. Flood water levels are insensitive to the ongoing measures of water retention in the tributary catchment despite the backwaters that can rise up to 1.5 m over a distance of 4 km from the confluence.

  19. Simultaneous deblending and interpolation using structure-oriented filters

    Science.gov (United States)

    Zhou, Yatong; Li, Song

    2018-03-01

    Simultaneous source shooting is a modern marine acquisition technology that accelerates field acquisition tremendously. However, we need to carefully remove the spike-like noise in the recorded seismic data, the process of which is called deblending. Considering the field obstacles, the recorded data may also contain missing traces. In this paper, we propose a very efficient way to simultaneously remove the spike-like noise to separate simultaneous sources and fill the data gaps in the recorded data. We propose to apply structure-oriented median and mean filters to reject the spike-like noise and restore the missing data. The commonly used median and mean filters guarantee the efficiency and convenience of the proposed algorithm framework. We use a robust slope estimation method to calculate the local slope of the structure patterns in the seismic data. Both synthetic and field data examples demonstrate the successful performance of the proposed algorithm. When compared with the state-of-the-art FK transform based projection onto convex sets (POCS) method, the presented method can obtain better performance with much less computational cost.

  20. Simultaneous neuron- and astrocyte-specific fluorescent marking

    Energy Technology Data Exchange (ETDEWEB)

    Schulze, Wiebke [Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871 (Japan); Hayata-Takano, Atsuko [Molecular Research Center for Children' s Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, 2-2 Yamadaoka, Suita, Osaka 565-0871 (Japan); Kamo, Toshihiko [Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871 (Japan); Nakazawa, Takanobu, E-mail: takanobunakazawa-tky@umin.ac.jp [iPS Cell-based Research Project on Brain Neuropharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871 (Japan); Nagayasu, Kazuki [iPS Cell-based Research Project on Brain Neuropharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871 (Japan); Kasai, Atsushi; Seiriki, Kaoru [Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871 (Japan); Interdisciplinary Program for Biomedical Sciences, Institute for Academic Initiatives, Osaka University, 1-1 Yamadaoka, Suita, Osaka 565-0871 (Japan); Shintani, Norihito [Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871 (Japan); Ago, Yukio [Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871 (Japan); Farfan, Camille [Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871 (Japan); and others

    2015-03-27

    Systematic and simultaneous analysis of multiple cell types in the brain is becoming important, but such tools have not yet been adequately developed. Here, we aimed to generate a method for the specific fluorescent labeling of neurons and astrocytes, two major cell types in the brain, and we have developed lentiviral vectors to express the red fluorescent protein tdTomato in neurons and the enhanced green fluorescent protein (EGFP) in astrocytes. Importantly, both fluorescent proteins are fused to histone 2B protein (H2B) to confer nuclear localization to distinguish between single cells. We also constructed several expression constructs, including a tandem alignment of the neuron- and astrocyte-expression cassettes for simultaneous labeling. Introducing these vectors and constructs in vitro and in vivo resulted in cell type-specific and nuclear-localized fluorescence signals enabling easy detection and distinguishability of neurons and astrocytes. This tool is expected to be utilized for the simultaneous analysis of changes in neurons and astrocytes in healthy and diseased brains. - Highlights: • We develop a method for the specific fluorescent labeling of neurons and astrocytes. • Neuron-specific labeling is achieved using Scg10 and synapsin promoters. • Astrocyte-specific labeling is generated using the minimal GFAP promoter. • Nuclear localization of fluorescent proteins is achieved with histone 2B protein.