Sample records for ultimate therapeutic goal


    Directory of Open Access Journals (Sweden)

    Amelia Limijaya


    Full Text Available This article aims to analyse the extent to which international accounting standards is applied and whether it is the ultimate goal. Up until the end of 2016, approximately there are 84% of the 149 jurisdictions analysed which require IFRS for all or most domestic publicly accountable entities. This may indicate that we are not that much further from having a single set of globally-accepted accounting standards. However, there is more to financial reporting than just accounting standards alone, such as the political aspect of accounting standard-setting, translation issues surrounding IFRS adoption, the US position and the complexity of financial reporting. Improving financial reporting quality needs more than just having global accounting standards, rather, it is also essential to consider the preparers’ incentives and other institutions surrounding the firm. Stakeholders need to broaden the perspective when viewing financial reporting, so that it will not be focused merely on accounting standards alone.

  2. Nanomedicine therapeutics and diagnostics are the goal. (United States)

    Miller, Andrew D


    Understanding and exploiting molecular mechanisms in biology is central to chemical biology. In 20 years, chemical biology research has advanced from simple mechanistic studies using isolated biological macromolecules to molecular-level and nanomolecular-level mechanistic studies involving whole organisms. This review documents the best of my personal and collaborative academic research work that has made use of a solid organic chemistry and chemical biology approach toward nanomedicine, in which my focus has been on the design, creation and use of synthetic, self-assembly lipid-based nanoparticle technologies for the functional delivery of active pharmaceutical ingredients to target cells in vivo. This research is now leading to precision therapeutics approaches (PTAs) for the treatment of diseases that may define the future of nanomedicine.

  3. The Utilization of Spin Polarized Photoelectron Spectroscopy as a Probe of Electron Correlation with an Ultimate Goal of Pu

    International Nuclear Information System (INIS)

    Tobin, James; Yu, Sung; Chung, Brandon; Morton, Simon; Komesu, Takashi; Waddill, George


    We are developing the technique of spin-polarized photoelectron spectroscopy as a probe of electron correlation with the ultimate goal of resolving the Pu electronic structure controversy. Over the last several years, we have demonstrated the utility of spin polarized photoelectron spectroscopy for determining the fine details of the electronic structure in complex systems such as those shown in the paper.

  4. Towards an Integrated Framework for SDGs: Ultimate and Enabling Goals for the Case of Energy

    Directory of Open Access Journals (Sweden)

    Tetsuro Yoshida


    Full Text Available Discussions on how to define, design, and implement sustainable development goals (SDG have taken center stage in the United Nations since the Rio+20 summit. Energy is one of the issues that enjoyed consensus, before and after Rio, as an important area for SDGs to address. Many proposals have been put forward on how SDGs should be formulated and what areas they should cover, but there have been few attempts to develop a generic integrated framework within which diverse areas can be accommodated and treated in a coherent way. The purpose of this paper is to develop such a framework for SDGs and to demonstrate its application by elaborating specific target areas for the energy sector. Based on a review and integration of global debates around SDG and energy, the framework puts human wellbeing at the center of the agenda, with the supporting resource base and global public goods forming additional tiers. A complementary set of enabling goals is suggested with four layers: capacity & knowledge, governance & institutions, public policy, and investment & finance. An energy SDG is elaborated to illustrate the application of the framework. The illustrative SDG architecture for energy includes eight target areas: basic energy access, energy for economic development, sufficiency, renewable supply, efficiency, infrastructure, greenhouse gas emissions and security. These target areas are relevant for energy for all countries, but depending on national circumstances such as levels of development, the relative emphasis will be different between countries, and over time.

  5. Diabetic patients' knowledge of therapeutic goals in Kuwait. (United States)

    Awad, Abdelmoneim; Dalle, Hala; Enlund, Hannes


    This study was conducted to analyze patients' knowledge about therapeutic goals for diabetic patients and factors associated with good knowledge. A total of 266 diabetic patients were randomly selected from 6 diabetes clinics in Kuwait to be included in a cross-sectional patient survey. Data were collected via face-to-face structured interviews using a pretested questionnaire. Descriptive and logistic regression analysis was used in data analysis. The response rate was 93% (n = 247). The percentages [95% confidence interval (CI)] of patients who reported knowing their recent levels of low-density lipoprotein cholesterol (LDL-C), blood pressure (BP), and glycosylated hemoglobin (HbA1c) were 5% (2-8), 54% (48-60), and 8% (5-11), respectively. The percentages (95% CI) of patients who admitted knowing the target goals for LDL-C, BP, HbA1c, fasting, and postprandial blood glucose levels were 3% (1-6), 49% (43-55), 6% (3-9), 62% (56-68) and 55% (49-61), respectively. Correct target goals for LDL-C, BP, HbA1c, fasting, and postprandial blood glucose levels were reported by 2% (1-4), 43% (37-49), 5% (2-8), 60% (54-66), and 47% (41-53), respectively. Those with a high education (OR = 4.76; 95% CI 2.34-9.68) and those with a family history of diabetes (OR = 3.05; 95% CI 1.50-6.19) had good knowledge about correct targets. The current findings revealed that lack of knowledge about recent levels of BP, LDL-C and HbA1c and therapeutic goals was alarmingly high, which highlights the need for the implementation of an effective multidisciplinary team approach to encourage patient education and self-care. Copyright © 2011 S. Karger AG, Basel.

  6. The impact of therapeutic delay time on acute scintigraphic lesion and ultimate scar formation in children with first febrile UTI. (United States)

    Oh, Mi Mi; Kim, Jin Wook; Park, Min Gu; Kim, Je Jong; Yoo, Kee Hwan; Moon, Du Geon


    We assessed the role of therapeutic delay time (TDT) in acute renal cortical scintigraphic lesion (ASL) and ultimate scar formation (USF) in children with first febrile UTI and whether it is affected by the presence of vesico-ureteral reflux (VUR). 230 children, 90 girls and 140 boys with first febrile UTI were included. Radiologic (USG, DMSA, and VCUG), clinical (age, gender, peak fever, therapeutic delay time) and laboratory (CBC with differential count, ANC (absolute neutrophil count), BUN, Creatinine, urine analysis, gram stain, culture, CRP and ESR) variables were analysed. DMSA was performed within 5 days and after six months. VCUG was performed after acute phase of UTI. The differences in TDT according to the presence of ASL, USF and VUR were assessed. And the correlation between ASL or USF with the duration of TDT was assessed. Of 230 patients enrolled, 142 patients had refluxing UTI and 88 patients had non-refluxing UTI. TDT was the risk factor associated with ASL and USF along with presence of VUR. TDT was longer in ASL positive group compared with the ASL negative group. Also USF group showed longer TDT compared with those without USF in both refluxing UTI and non refluxing UTI. The TDT was significantly shorter in USF group with the presence of VUR. Positive linear association was noted between prevalence of ASL and USF and duration of TDT. In conclusion, the impact of UTI on formation of USF may be enhanced by the presence of VUR with shorter duration of TDT.

  7. [Therapeutic goals and indications: psychotherapy patient's self-reports during diagnostic assessment]. (United States)

    Faller, H


    Although individual therapeutic goals are considered to be important factors motivating patients to engage in therapeutic work, they have gained little attention in empirical research. In the present study, patients were given a questionnaire containing 24 therapeutic goals which could be rated according to their subjective relevance on a 5-point scale. N = 152 patients (mean age 34.5 years, 59.2% female) who presented at a university psychotherapy outpatient department to attend a diagnostic interview participated in the study. "To solve my problems" and "to get relief from my complaints" were the goals that were rated as most important. Goals pertaining to mental health such as more contentness and calmness, self-assertion and insight scored high, too. Three rational scales were constructed: 1. insight, 2. sociability, and 3. self-assertion. These scales were correlated with both patients' causal attributions and therapy expectations in plausible ways. However, the general strength of intercorrelations point of the conception patients goals were not very succinct at the time of the intake interview. Indication groups regarding specific therapeutic measures did not differ with respect to therapy goals. Only the general decision whether to recommend a psychotherapeutic intervention or not seemed to be influenced by patients' therapeutic aims.

  8. Pushed by Symptoms, Pulled by Values: Promotion Goals Increase Motivation in Therapeutic Tasks. (United States)

    Katz, Benjamin A; Catane, Sara; Yovel, Iftah


    While many therapies focus on the reduction of disturbing symptoms, others pursue behavior consistent with personally held values. Based on regulatory focus theory (Higgins, 1997), reducing symptoms is a type of prevention goal while pursuing values is a promotion goal. In the current study, 123 undergraduate students elicited a negative, self-focused emotion-laden cognition. They were then randomly assigned to construe their negative thought as either (a) an impediment to valued behaviors, (b) a cause of unpleasant symptoms, or to one of two control conditions: (c) distraction or (d) no intervention. Then, participants in all groups completed a series of repetitive therapeutic tasks that targeted their elicited negative cognitions. Results showed that participants who construed treatment in terms of valued behavior promotion spent more time on a therapeutic task than all other groups. The group in the unpleasant symptom promotion condition did not differ from either control group. The motivational advantage of value promotion was not accounted for by differences in mood. The present findings suggest that clients may be better motivated through value promotion goals, as opposed to symptom prevention goals. Copyright © 2015. Published by Elsevier Ltd.

  9. The relationship between patients' knowledge of diabetes therapeutic goals and self-management behaviour, including adherence. (United States)

    Waheedi, Mohammad; Awad, Abdelmoneim; Hatoum, Hind T; Enlund, Hannes


    Background The Middle East region has one the highest prevalence rates of diabetes in the world. Little is known about the determinants of adherence and the role of knowledge in diabetes self-management within these populations. Objective To investigate the relationship between patients knowledge of diabetes therapeutic targets with adherence to self-care measures in a sample of patients with type 2 diabetes in Kuwait. Setting Primary care chronic care clinics within the Ministry of Health of Kuwait. Methods A cross sectional survey was carried out with 238 patients from six clinics. A multistage stratified clustered sampling method was used to first randomly select the clinics and the patients. Self-reported adherence to three behaviours: medication taking, diet and physical activity. Results Respondents were able to correctly report a mean (SD) of 1.6 (1.3) out of 5 of the pre-specified treatment targets. Optimal adherence to physical activity, diet and medications was reported in 25, 33 and 47 % of the study cohort, respectively. A structural equation model analysis showed better knowledge of therapeutic goals and own current levels translated into better adherence to medications, diet and physical activity. Conclusion Knowledge of therapeutic goals and own recent levels is associated with adherence to medications, diet, or physical activity in this Kuwaiti cohort of patients with diabetes. Low adherence to self-care management and poor overall knowledge of diabetes is a big challenge to successful diabetes care in Kuwait.

  10. Achievement of Therapeutic Goals with Low-Dose Imiglucerase in Gaucher Disease: A Single-Center Experience

    Directory of Open Access Journals (Sweden)

    Irina Tukan


    Full Text Available Gaucher disease, a lysosomal storage disorder, is a multisystem disorder with variable and unpredictable onset and severity. Disease-specific enzyme replacement therapy (ERT has been shown to reverse or ameliorate disease-specific hepatosplenomegaly and anemia and thrombocytopenia. ERT also impacts bone manifestations, including bone crises, bone pain, and appearance of new osteonecrosis, and improves bone mineral density to varying degrees. The objective of this study was to assess achievement of predefined therapeutic goals based on international registry outcomes for Israeli patients with Gaucher disease receiving imiglucerase for four consecutive years on a low-dose regimen followed in a single center. All data were taken from patient files. The therapeutic goals were taken from standards published in the literature for disease-specific clinical parameters. Among 164 patients at baseline, values for spleen and liver volumes, hemoglobin and platelet counts, and Z-scores for lumbar spine and femoral were significantly different from the goal. After four years ERT, there was a significant improvement ( in each of the therapeutic goal parameters from baseline. 15.2% of these patients achieved all hematology-visceral goals. In children, there was achievement of linear growth and puberty. This survey highlights the good overall response in symptomatic patients receiving low-dose ERT with imiglucerase in Israel.

  11. [The impact of therapeutic inertia and the degree of the medication adherence on the control goals for patients with diabetes]. (United States)

    López-Simarro, F; Moral, I; Aguado-Jodar, A; Cols-Sagarra, C; Mancera-Romero, J; Alonso-Fernández, M; Miravet-Jiménez, S; Brotons, C


    The purpose of this study was to analyse both the impact of low therapeutic adherence (TA) and therapeutic inertia (TI) on poor blood glucose control and on risk factors for heart disease in patients with DM2. A cross-sectional study was conducted in a Primary Halth Care centre. A total of 320 patients with DM2 were included and an assessment was made of control goals (HbA1c≤7%, blood pressure ≤130/80mmHg, and LDL-cholesterol≤100mg/dl). A pharmacy retrieval inertia were found in a high percentage of poorly-controlled DM2 patients with bad control. Therapeutic inertia was found to be of great relevance in this study. Copyright © 2017 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

  12. Junctures to the therapeutic goal of diabetes mellitus: Experience in a tertiary care hospital of Kolkata

    Directory of Open Access Journals (Sweden)

    S K Lahiri


    Conclusion : Patient-providers collaboration is to be developed through a patient-centered care model based on the mutual responsibility of both so that each patient is considered in the mesh of his/her other goals of life and helped to promote empowerment to take informed decision for behavioral change conducive to control the disease.

  13. Severe hypercholesterolaemia: therapeutic goals and eligibility criteria for LDL apheresis in Europe.

    NARCIS (Netherlands)

    Thompson, G.R.; Catapano, A.; Saheb, S.; Atassi-Dumont, M.; Barbir, M.; Eriksson, M.; Paulweber, B.; Sijbrands, E.; Stalenhoef, A.F.H.; Parhofer, K.G.


    PURPOSE OF REVIEW: Despite the use of currently available lipid-lowering therapies, a significant proportion of patients with severe hypercholesterolaemia do not reach treatment goals and consequently remain at increased risk for cardiovascular disease (CVD). On the basis of clinical experience,

  14. Comparing Online and Face-to-Face Student Counselling: What Therapeutic Goals Are Identifed and What Are the Implications for Educational Providers? (United States)

    Hanley, Terry; Ersahin, Zehra; Sefi, Aaron; Hebron, Judith


    Online counselling is increasingly being used as an alternative to face-to-face student counselling. Using an exploratory mixed methods design, this project investigated the practice by examining the types of therapeutic goals that 11- to 25-year-olds identify online in routine practice. These goals were then compared to goals identified in…

  15. Flux scaling: Ultimate regime

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Flux scaling: Ultimate regime. With the Nusselt number and the mixing length scales, we get the Nusselt number and Reynolds number (w'd/ν) scalings: and or. and. scaling expected to occur at extremely high Ra Rayleigh-Benard convection. Get the ultimate regime ...

  16. Treatment-naïve Gaucher disease patients achieve therapeutic goals and normalization with velaglucerase alfa by 4years in phase 3 trials. (United States)

    Zimran, Ari; Elstein, Deborah; Gonzalez, Derlis E; Lukina, Elena A; Qin, Yulin; Dinh, Quinn; Turkia, Hadhami Ben


    Gaucher disease is an inherited metabolic disease characterized by β-glucocerebrosidase deficiency and commonly treated with enzyme replacement therapy (ERT). The efficacy of ERT with velaglucerase alfa was assessed based on the achievement of published therapeutic goals and the normalization of disease parameters in 39 treatment-naïve patients with type 1 Gaucher disease, 6 to 62years of age, enrolled in phase 3 clinical trials. After 4years of ERT, therapeutic goals for thrombocytopenia and splenomegaly had been achieved in 100% of patients; goals for anemia and hepatomegaly had been achieved in 95% and 94% of patients, respectively. Consistent with the goal for bone mineral density, lumbar spine bone density improved in 87% of patients ≥18years of age. At year 4, compared with clinical ranges for healthy individuals, 86% of patients with a low baseline hemoglobin concentration had normalized, 60% with a low baseline platelet count had normalized, 67% with baseline splenomegaly had normalized, 58% with hepatomegaly had normalized, and lumbar spine bone density had normalized in 53% of adults. The decade-old therapeutic goals do not reflect the potential for normalization of clinical parameters in ERT-treated patients. Goals consistent with normalization or near-normalization should be considered. identifiers: NCT00430625, NCT00553631, NCT00635427. Copyright © 2016 Shire Human Genetic Therapies, Inc. Published by Elsevier Inc. All rights reserved.

  17. Stalking the ultimate particle

    CERN Multimedia


    If you missed the ARTE programme entitled "L'Ultime Particule" broadcast in February, you have another chance to catch it in CERN's Main Auditorium on 13 March. "L'Ultime Particule" is a documentary by the French director Michel Andrieu that seeks to explain particle physics through a contemplative quest for the research physicists of matter of today and yesteryear. Invariably kitted out in a red parka and a soft hat, the programme's investigator scours the planet and the archives in search of the research physicists who are stalking the ultimate particle, the Higgs boson, in their quest to understand the structure of matter. Naturally enough, CERN is an important stage of his journey where Michel Andrieu and his team spent several days last year. Both from the physics and metaphysical points of view, "L'Ultime Particule" is worth seeing. The film's director, Michel Andrieu, will introduce his documentary and answer questions from the audience after the documentary has been shown. L'Ultime Particule by Mic...

  18. The ultimate quotable Einstein

    CERN Document Server


    Here is the definitive new edition of the hugely popular collection of Einstein quotations that has sold tens of thousands of copies worldwide and been translated into twenty-five languages. The Ultimate Quotable Einstein features 400 additional quotes, bringing the total to roughly 1,600 in all. This ultimate edition includes new sections--"On and to Children," "On Race and Prejudice," and "Einstein's Verses: A Small Selection"--as well as a chronology of Einstein's life and accomplishments, Freeman Dyson's authoritative foreword, and new commentary by Alice Calaprice.

  19. The Ultimate Technology

    DEFF Research Database (Denmark)

    Riis, Søren


    One of the most influential philosophers of the 20th century, Martin Heidegger (1889-1976), died prior to the remarkable cloning of the sheep Dolly and before Dr. Venter started his experiments on creating synthetic life, and he never explicitly discussed living technologies. However, by reinterp......One of the most influential philosophers of the 20th century, Martin Heidegger (1889-1976), died prior to the remarkable cloning of the sheep Dolly and before Dr. Venter started his experiments on creating synthetic life, and he never explicitly discussed living technologies. However......, by reinterpreting his notion of "modern technology," this article shows how it is possible to philosophically assess living technologies and to recognize ways in which Heidegger anticipated this phenomenon with his notion of cybernetics. The interpretation elucidates the fundamental process of technology becoming...... living and simultaneously presents living technology as the ultimate technology. The thesis of this article is that living technology is not just one more technology; rather, it is the perfection of technology as understood by Aristotle. Aristotle's thinking is in this way a key example of a profound...

  20. The effects of treatment adherence and treatment-specific therapeutic competencies on outcome and goal attainment in telephone-based therapy with caregivers of people with dementia. (United States)

    Schinköthe, Denise; Altmann, Uwe; Wilz, Gabriele


    Contradictory results have been found for the impact of therapist's adherence and competence on intervention outcomes. Most studies focus on generic aspects of competence and adherence, rather than taking into account treatment-specific aspects or specific challenges of the clientele. Appropriate analyses are lacking for cognitive behavioral therapy (CBT) with caregivers of people with dementia. In a sample of 43 caregivers, we examined adherence and different competence ratings of 80 complete sessions, as predictors of symptom change and goal attainment. Therapist's competence was evaluated by four raters, using an adapted version of the cognitive therapy scale (CTS) on three subscales of competence: General therapeutic (GT), session-structuring (SS), and treatment-specific CBT technique (CT). Therapist's adherence to the manual was also assessed. The results show that GT competencies were associated with lower post-test depression scores and that CT competencies predicted a decrease in caregiver burden and higher goal attainment, while SS competencies predicted higher post-test burden. Therapist's adherence had no relationship to outcome, but the higher application of modifying dysfunctional thoughts was associated with higher goal attainment. The results suggest the importance of treatment-specific competencies for outcome. Future research should identify empirically what kind of therapeutic behavior is appropriate to the challenges of a specific clientele such as caregivers of people with dementia.

  1. 'Radiooncology 2007: High quality of life, the ultimate goal'. Abstracts

    International Nuclear Information System (INIS)


    The 13th annual congress of Deutsche Gesellschaft fuer Radioonkologie e.V. discussed clinical radiotherapy, medical physics and radiation biology, as well as an extensive programme of working groups on radiology in medical technology, care, and office. The focus was on new equipment (from image-supported to image-guided radiotherapy) and new approaches of targeted tumour therapy. Aspects of life quality are coming to the fore and will get even more important in the future. (orig.)

  2. Hemodynamic and oxygen transport patterns for outcome prediction, therapeutic goals, and clinical algorithms to improve outcome. Feasibility of artificial intelligence to customize algorithms. (United States)

    Shoemaker, W C; Patil, R; Appel, P L; Kram, H B


    A generalized decision tree or clinical algorithm for treatment of high-risk elective surgical patients was developed from a physiologic model based on empirical data. First, a large data bank was used to do the following: (1) describe temporal hemodynamic and oxygen transport patterns that interrelate cardiac, pulmonary, and tissue perfusion functions in survivors and nonsurvivors; (2) define optimal therapeutic goals based on the supranormal oxygen transport values of high-risk postoperative survivors; (3) compare the relative effectiveness of alternative therapies in a wide variety of clinical and physiologic conditions; and (4) to develop criteria for titration of therapy to the endpoints of the supranormal optimal goals using cardiac index (CI), oxygen delivery (DO2), and oxygen consumption (VO2) as proxy outcome measures. Second, a general purpose algorithm was generated from these data and tested in preoperatively randomized clinical trials of high-risk surgical patients. Improved outcome was demonstrated with this generalized algorithm. The concept that the supranormal values represent compensations that have survival value has been corroborated by several other groups. We now propose a unique approach to refine the generalized algorithm to develop customized algorithms and individualized decision analysis for each patient's unique problems. The present article describes a preliminary evaluation of the feasibility of artificial intelligence techniques to accomplish individualized algorithms that may further improve patient care and outcome.

  3. The discovery of how gender influences age immunological mechanisms in health and disease, and the identification of ageing gender-specific biomarkers, could lead to specifically tailored treatment and ultimately improve therapeutic success rates

    Directory of Open Access Journals (Sweden)

    Berghella Anna


    Full Text Available Abstract The control of human health and diseases in the elderly population is becoming a challenge, since mean age and life expectation are progressively increasing as well as chronic degenerative diseases. These disorders are of complex diagnosis and they are difficult to be treated, but it is hoped that the predictive medicine will lead to more specific and effective treatment by using specific markers to identify persons with high risk of developing disease, before the clinical manifestation. Peripheral blood targets and biomarkers are currently the most practical, non-invasive means of disease diagnosing, predicting prognosis and therapeutic response. Human longevity is directly correlated with the optimal functioning of the immune system. Recent findings indicate that the sexual dimorphism of T helper (Th cytokine pathways and the regulation of Th cell network homeostasis are normally present in the immune response and undergoes to adverse changes with ageing. Furthermore, immune senescence affects both men and women, but it does not affect them equally. Therefore, we hypothesize that the comprehension of the interferences between these gender specific pathways, the ageing immunological mechanism in pathological or healthy state and the current therapies, could lead to specifically tailored treatment and eventually improve the therapeutic success rates. Reaching this aim requires the identification of ageing gender-specific biomarkers that could easily reveal the above mentioned correlations.

  4. Shear wall ultimate drift limits

    International Nuclear Information System (INIS)

    Duffey, T.A.; Goldman, A.; Farrar, C.R.


    Drift limits for reinforced-concrete shear walls are investigated by reviewing the open literature for appropriate experimental data. Drift values at ultimate are determined for walls with aspect ratios ranging up to a maximum of 3.53 and undergoing different types of lateral loading (cyclic static, monotonic static, and dynamic). Based on the geometry of actual nuclear power plant structures exclusive of containments and concerns regarding their response during seismic (i.e.,cyclic) loading, data are obtained from pertinent references for which the wall aspect ratio is less than or equal to approximately 1, and for which testing is cyclic in nature (typically displacement controlled). In particular, lateral deflections at ultimate load, and at points in the softening region beyond ultimate for which the load has dropped to 90, 80, 70, 60, and 50 percent of its ultimate value, are obtained and converted to drift information. The statistical nature of the data is also investigated. These data are shown to be lognormally distributed, and an analysis of variance is performed. The use of statistics to estimate Probability of Failure for a shear wall structure is illustrated

  5. Ultimate disposal of radioactive wastes

    International Nuclear Information System (INIS)

    Roethemeyer, H.


    The activities developed by the Federal Institution of Physical Engineering PTB and by the Federal Office for Radiation Protection (BfS) concentrated, among others, on work to implement ultimate storage facilities for radioactive wastes. The book illuminates this development from site designation to the preliminary evaluation of the Gorleben salt dome, to the preparation of planning documents proving that the Konrad ore mine is suitable for a repository. The paper shows the legal provisions involved; research and development tasks; collection of radioactive wastes ready for ultimate disposal; safety analysis in the commissioning and post-operational stages, and product control. The historical development of waste management in the Federal Republic of Germany and international cooperation in this area are outlined. (DG) [de

  6. Ultimate fate of constrained voters

    International Nuclear Information System (INIS)

    Vazquez, F; Redner, S


    We examine the ultimate fate of individual opinions in a socially interacting population of leftists, centrists and rightists. In an elemental interaction between agents, a centrist and a leftist can both become centrists or both become leftists with equal rates (and similarly for a centrist and a rightist). However leftists and rightists do not interact. This interaction step between pairs of agents is applied repeatedly until the system can no longer evolve. In the mean-field limit, we determine the exact probability that the system reaches consensus (either leftist, rightist or centrist) or a frozen mixture of leftists and rightists as a function of the initial composition of the population. We also determine the mean time until the final state is reached. Some implications of our results for the ultimate fate in a limit of the Axelrod model are discussed

  7. Ultimate fate of constrained voters

    Energy Technology Data Exchange (ETDEWEB)

    Vazquez, F [Department of Physics, Center for BioDynamics, Boston University, Boston, MA 02215 (United States); Redner, S [Department of Physics, Center for Polymer Studies, Boston University, Boston, MA 02215 (United States)


    We examine the ultimate fate of individual opinions in a socially interacting population of leftists, centrists and rightists. In an elemental interaction between agents, a centrist and a leftist can both become centrists or both become leftists with equal rates (and similarly for a centrist and a rightist). However leftists and rightists do not interact. This interaction step between pairs of agents is applied repeatedly until the system can no longer evolve. In the mean-field limit, we determine the exact probability that the system reaches consensus (either leftist, rightist or centrist) or a frozen mixture of leftists and rightists as a function of the initial composition of the population. We also determine the mean time until the final state is reached. Some implications of our results for the ultimate fate in a limit of the Axelrod model are discussed.

  8. Patients' empowerment , physicians' perceptions, and achievement of therapeutic goals in patients with type 1 and type 2 diabetes mellitus in Mexico

    Directory of Open Access Journals (Sweden)

    Lavalle-González FJ


    Full Text Available Fernando J Lavalle-González,1 Erwin Chiquete2 On behalf of the IDMPS-3W Collaborative Group (Mexico 1Department of Endocrinology, Hospital Universitario Dr José Eleuterio González, Monterrey, NL, 2Department of Neurology and Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico Background: Physicians’ perception may not parallel objective measures of therapeutic targets in patients with diabetes. This is an issue rarely addressed in the medical literature. We aimed to analyze physicians’ perception and characteristics of adequate control of patients with diabetes.Patients and methods: We studied information on physicians and their patients who participated in the third wave of the International Diabetes Management Practices Study registry in Mexico. This analysis was performed on 2,642 patients, 203 with type 1 diabetes mellitus (T1DM and 2,439 with type 2 diabetes mellitus (T2DM, treated by 200 physicians.Results: The patients perceived at target had lower hemoglobin A1c (HbA1c and fasting blood glucose than those considered not at target. However, overestimation of the frequency of patients with HbA1c <7% was 41.5% in patients with T1DM and 31.7% in patients with T2DM (underestimation: 2.8% and 8.0%, respectively. The agreement between the physicians’ perception and the class of HbA1c was suboptimal (κ: 0.612. Diabetologists and endocrinologists tested HbA1c more frequently than primary care practitioners, internists, or cardiologists; however, no differences were observed in mean HbA1c, for both T1DM (8.4% vs 7.2%, P=0.42 and T2DM (8.03% vs 8.01%, P=0.87 patients. Nevertheless, insulin users perceived at target, who practiced self-monitoring and self-adjustment of insulin, had a lower mean HbA1c than patients without these characteristics (mean HbA1c in T1DM: 6.8% vs 9.6%, respectively; mean HbA1c in T2DM: 7.0% vs 10.1%, respectively.Conclusion: Although there is a significant

  9. Experimental investigation of ultimate loads

    Energy Technology Data Exchange (ETDEWEB)

    Petersen, S M; Larsen, G C; Antoniou, I; Lind, S O; Courtney, M [Risoe National Lab., Wind Energy and Atmospheric Physics, Roskilde (Denmark)


    Verification of the structural integrity of a wind turbine involves analysis of fatigue loading as well as ultimate loading. With the trend of persistently growing turbines, the ultimate loading seems to become relatively more important. For wind turbines designed according to the wind conditions prescribed in the IEC-61400 code, the ultimate load is often identified as the leading load parameter. Exemplified by the use of an extensive measurement campaign a procedure for evaluation of the extreme flap-wise bending moments, occurring during normal operating of a wind turbine, is presented. The structural measurements are made on a NEG Micon 650 kW wind turbine erected at a complex high wind site in Oak Creek, California. The turbine is located on the top of a ridge. The prevailing wind direction is perpendicular to the ridge, and the annual mean wind speed is 9.5 m/s. The associated wind field measurement, are taken from two instrumented masts erected less than one rotor diameter in front of the turbine in direction of the prevailing wind direction. Both masts are instrumented at different heights in order to gain insight of the 3D-wind speed structure over the entire rotor plane. Extreme distributions, associated with a recurrence period of 10 minutes, conditioned on the mean wind speed and the turbulence intensity are derived. Combined with the wind climate model proposed in the IEC standard, these distributions are used to predict extreme distributions with recurrence periods equal to one and fifty years, respectively. The synthesis of the conditioned PDF`s and the wind climate model is performed by means of Monte Carlo simulation. (au)

  10. Ultimate Explanations of the Universe

    CERN Document Server

    Heller, Michael


    We humans are collectively driven by a powerful - yet not fully explained - instinct to understand. We would like to see everything established, proven, laid bare. The more important an issue, the more we desire to see it clarified, stripped of all secrets, all shades of gray. What could be more important than to understand the Universe and ourselves as a part of it? To find a window onto our origin and our destiny? This book examines how far our modern cosmological theories - with their sometimes audacious models, such as inflation, cyclic histories, quantum creation, parallel universes - can take us towards answering these questions. Can such theories lead us to ultimate truths, leaving nothing unexplained? Last, but not least, Heller addresses the thorny problem of why and whether we should expect to find theories with all-encompassing explicative power.

  11. Ultimate loading of wind turbines

    DEFF Research Database (Denmark)

    Larsen, Gunner Chr.; Ronold, K.; Ejsing Jørgensen, Hans


    An extreme loading study has been conducted comprising a general wind climate analysis as well as a wind turbine reliability study. In the wind climate analysis, the distribution of the (horizontal) turbulence standard deviation, conditioned on the meanwind speed, has been approximated by fitting......, a design turbulence intensity for off-shore application is proposed which, in the IEC code framework, is applicable for extreme as well as for fatigue loaddetermination. In order to establish a rational method to analyse wind turbine components with respect to failure in ultimate loading, and in addition...... a three parameter Weibull distribution to the measured on-shore and off-shore data for wind speed variations. Specific recommendations on off-shore design turbulence intensities are lacking in the presentIEC-code. Based on the present analysis of the off-shore wind climate on two shallow water sites...

  12. Ultimate explanations and suboptimal choice. (United States)

    Vasconcelos, Marco; Machado, Armando; Pandeirada, Josefa N S


    Researchers have unraveled multiple cases in which behavior deviates from rationality principles. We propose that such deviations are valuable tools to understand the adaptive significance of the underpinning mechanisms. To illustrate, we discuss in detail an experimental protocol in which animals systematically incur substantial foraging losses by preferring a lean but informative option over a rich but non-informative one. To understand how adaptive mechanisms may fail to maximize food intake, we review a model inspired by optimal foraging principles that reconciles sub-optimal choice with the view that current behavioral mechanisms were pruned by the optimizing action of natural selection. To move beyond retrospective speculation, we then review critical tests of the model, regarding both its assumptions and its (sometimes counterintuitive) predictions, all of which have been upheld. The overall contention is that (a) known mechanisms can be used to develop better ultimate accounts and that (b) to understand why mechanisms that generate suboptimal behavior evolved, we need to consider their adaptive value in the animal's characteristic ecology. Copyright © 2018 Elsevier B.V. All rights reserved.

  13. MOTIVATION: Goals and Goal Setting (United States)

    Stratton, Richard K.


    Goal setting has great impact on a team's performance. Goals enable a team to synchronize their efforts to achieve success. In this article, the author talks about goals and goal setting. This articles complements Domain 5--Teaching and Communication (p.14) and discusses one of the benchmarks listed therein: "Teach the goal setting process and…

  14. The ultimate challenge of pregnancy-associated breast carcinoma

    International Nuclear Information System (INIS)

    Raja, R.; Tahira, A.


    Pregnancy associated breast carcinoma requires making judicious use of all diagnostic modalities and the therapeutic options of surgery, irradiation, chemotherapy and hormonal therapy to enhance survival rates. Individualization of treatment for each patient is the key to success. The effects on future fertility, the time interval before next conception, and whether to breast feed or not are all well-documented. A multidisciplinary coordinated team approach to this ultimate challenge of patient care will prove fruitful. (author)

  15. The dream of an ultimate theory

    International Nuclear Information System (INIS)

    Weinberg, S.


    Steven Weinberg describes how the dream of an ultimate theory began when one tried to unify the fundamental laws governing the stars constellations as elementary particles: electromagnetism, weak-electro theory then standard model which gives only one quantity out of its fields, the gravitation. He tries to explain to what an ultimate theory could look like. but the dream of an ultimate theory is not yet realized, there are some elementary particles to find before and then to build superconducting super colliders. The europe made it. the dream of an ultimate theory became an european dream. (N.C.)

  16. Adherence to the gluten-free diet can achieve the therapeutic goals in almost all patients with coeliac disease: A 5-year longitudinal study from diagnosis. (United States)

    Newnham, Evan D; Shepherd, Susan J; Strauss, Boyd J; Hosking, Patrick; Gibson, Peter R


    Key aims of treatment of coeliac disease are to heal the intestinal mucosa and correct nutritional abnormalities. We aim to determine prospectively the degree of success and time course of achieving those goals with a gluten-free diet. Ninety-nine patients were enrolled at diagnosis and taught the diet. The first 52 were reassessed at 1 year and 46 at 5 years, 25 being assessed at the three time points regarding dietary compliance (dietitian-assessed), coeliac serology, bone mineral density and body composition analysis by dual energy X-ray absorptiometry, and intestinal histology. Mean age (range) was 40 (18-71) years and 48 (76%) were female. Dietary compliance was very good to excellent in all but one. Tissue transglutaminase IgA was persistently elevated in 44% at 1 year and 30% at 5 years and were poorly predictive of mucosal disease. Rates of mucosal remission (Marsh 0) and response (Marsh 0/1) were 37% and 54%, and 50% and 85% at 1 and 5 years, respectively. Fat mass increased significantly over the first year in those with normal/reduced body mass index. Lean body mass indices more slowly improved irrespective of status at diagnosis with significant improvement at 5 years. Bone mass increased only in those with osteopenia or osteoporosis, mostly in year 1. Dietary compliance is associated with a high chance of healing the intestinal lesion and correction of specific body compositional abnormalities. The time course differed with body fat improving within 1 year, and correction of the mucosal lesion and improvement in lean mass and bone mass taking longer. © 2015 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

  17. Patients' empowerment, physicians' perceptions, and achievement of therapeutic goals in patients with type 1 and type 2 diabetes mellitus in Mexico. (United States)

    Lavalle-González, Fernando J; Chiquete, Erwin


    Physicians' perception may not parallel objective measures of therapeutic targets in patients with diabetes. This is an issue rarely addressed in the medical literature. We aimed to analyze physicians' perception and characteristics of adequate control of patients with diabetes. We studied information on physicians and their patients who participated in the third wave of the International Diabetes Management Practices Study registry in Mexico. This analysis was performed on 2,642 patients, 203 with type 1 diabetes mellitus (T1DM) and 2,439 with type 2 diabetes mellitus (T2DM), treated by 200 physicians. The patients perceived at target had lower hemoglobin A1c (HbA1c) and fasting blood glucose than those considered not at target. However, overestimation of the frequency of patients with HbA1c <7% was 41.5% in patients with T1DM and 31.7% in patients with T2DM (underestimation: 2.8% and 8.0%, respectively). The agreement between the physicians' perception and the class of HbA1c was suboptimal (κ: 0.612). Diabetologists and endocrinologists tested HbA1c more frequently than primary care practitioners, internists, or cardiologists; however, no differences were observed in mean HbA1c, for both T1DM (8.4% vs 7.2%, P=0.42) and T2DM (8.03% vs 8.01%, P=0.87) patients. Nevertheless, insulin users perceived at target, who practiced self-monitoring and self-adjustment of insulin, had a lower mean HbA1c than patients without these characteristics (mean HbA1c in T1DM: 6.8% vs 9.6%, respectively; mean HbA1c in T2DM: 7.0% vs 10.1%, respectively). Although there is a significant physicians' overestimation about the optimal glycemic control, this global impression and characteristics of patients' empowerment, such as self-monitoring and self-adjustment of insulin, are associated with the achievement of targets.

  18. Patients’ empowerment, physicians’ perceptions, and achievement of therapeutic goals in patients with type 1 and type 2 diabetes mellitus in Mexico (United States)

    Lavalle-González, Fernando J; Chiquete, Erwin


    Background Physicians’ perception may not parallel objective measures of therapeutic targets in patients with diabetes. This is an issue rarely addressed in the medical literature. We aimed to analyze physicians’ perception and characteristics of adequate control of patients with diabetes. Patients and methods We studied information on physicians and their patients who participated in the third wave of the International Diabetes Management Practices Study registry in Mexico. This analysis was performed on 2,642 patients, 203 with type 1 diabetes mellitus (T1DM) and 2,439 with type 2 diabetes mellitus (T2DM), treated by 200 physicians. Results The patients perceived at target had lower hemoglobin A1c (HbA1c) and fasting blood glucose than those considered not at target. However, overestimation of the frequency of patients with HbA1c <7% was 41.5% in patients with T1DM and 31.7% in patients with T2DM (underestimation: 2.8% and 8.0%, respectively). The agreement between the physicians’ perception and the class of HbA1c was suboptimal (κ: 0.612). Diabetologists and endocrinologists tested HbA1c more frequently than primary care practitioners, internists, or cardiologists; however, no differences were observed in mean HbA1c, for both T1DM (8.4% vs 7.2%, P=0.42) and T2DM (8.03% vs 8.01%, P=0.87) patients. Nevertheless, insulin users perceived at target, who practiced self-monitoring and self-adjustment of insulin, had a lower mean HbA1c than patients without these characteristics (mean HbA1c in T1DM: 6.8% vs 9.6%, respectively; mean HbA1c in T2DM: 7.0% vs 10.1%, respectively). Conclusion Although there is a significant physicians’ overestimation about the optimal glycemic control, this global impression and characteristics of patients’ empowerment, such as self-monitoring and self-adjustment of insulin, are associated with the achievement of targets. PMID:27555751

  19. Prevalence of Obesity and Its Influence on Achievement of Cardiometabolic Therapeutic Goals in Chinese Type 2 Diabetes Patients: An Analysis of the Nationwide, Cross-Sectional 3B Study.

    Directory of Open Access Journals (Sweden)

    Xianghai Zhou

    Full Text Available There are few data on the prevalence of obesity and its influence on achieving blood glucose, blood pressure, and blood lipid (3B goals in Chinese type 2 diabetes outpatients.Patient demographic data, anthropometric measurements, medications, and blood glucose and lipid profiles of 24,512 type 2 diabetes patients from a large, geographically diverse study (CCMR-3B were analyzed. Using cut-points for body mass index (BMI and waist circumference (WC recommended by the Working Group on Obesity in China, overweight and obesity were defined as BMIs of 24-27.9 kg/m2 and ≥28.0 kg/m2. Central obesity was defined as a waist circumference ≥80 cm in women and ≥85 cm in men. The 3B therapeutic goals were HbA1c<7.0%, BP<140/90 mmHg and LDL-C<2.6 mmol/L.Overall, 43.0% of type 2 diabetes patients were overweight and 16.7% were obese; 13.3% of overweight and and 10.1% of obese patients achieved all the 3B target goals. Overweight or obese patients were less likely to achieve 3B goals than those with normal BMIs. More than a half the overweight or obese patients (69.6% were centrally obese. Patients with abdominal obesity were less likely to achieve cardiometabolic targets than those without abdominal obesity. In multivariate logistic regression analysis, female, higher BMI and waist circumference, smoking, drinking, sedentary lifestyle, and longer diabetes duration were significantly correlated with failure to achieve 3B control goals.Obesity is highly prevalent and associated with poor 3B control in Chinese type 2 diabetes patients. In clinical practice, more attention and resources should focus on weight loss for such patients.

  20. Concussion Prevalence in Competitive Ultimate Frisbee Players (United States)

    Lazar, Damien J.; Lichtenstein, Jonathan D.; Tybor, David J.


    Background: Ultimate Frisbee (ultimate) is a fast-growing, popular sport played nationally by over 4 million athletes. While several studies have examined injury rates in ultimate, no work has investigated the prevalence of concussions specifically or players’ knowledge and management of those injuries. Purpose: To estimate the lifetime prevalence of concussions in ultimate and to assess players’ knowledge of concussions as well as their concussion management behaviors. Study Design: Descriptive epidemiology study. Methods: From June to November 2015, we collected ultimate-related concussion data via an anonymous web-based survey, the Concussion in Ultimate Frisbee Survey, from a convenience sample of 787 male and female ultimate players across the United States. Results: There were 553 male and 234 female respondents included in the analysis; 26.58% of men and 24.79% of women reported that they had sustained at least 1 concussion while playing ultimate, with 45.58% and 43.10% of those men and women, respectively, reporting multiple concussions. A total of 67.81% of men and 78.21% of women stated that they would remove themselves from play after sustaining a given concussion, although 45.99% of men and 37.62% of women indicated that they had returned to play in the same game or practice. Conclusion: Our preliminary data suggest that concussions do commonly occur in competitive ultimate and that better education and management of concussions in ultimate athletes are needed. This study is an important first step in deepening our understanding of these issues. PMID:29552572

  1. Physical demands in competitive ultimate frisbee

    DEFF Research Database (Denmark)

    Krustrup, Peter; Mohr, Magni


    The objective was to study game demands in competitive ultimate Frisbee by performing match analysis during a game. Thirteen moderately trained (Yo-Yo intermittent recovery test levels 1 and 2 [Yo-Yo IR1 and IR2] performance: 1790 ± 382 m and 657 ± 225 m, respectively) competitive male ultimate...... = 0.74, p ≤ 0.05). Ultimate Frisbee is an intense intermittent team sport with high cardiovascular loading and clear indications of fatigue toward the end of each half. Yo-Yo IR test performances correlate with physical match performance....

  2. Goal Definition

    DEFF Research Database (Denmark)

    Bjørn, Anders; Laurent, Alexis; Owsianiak, Mikołaj


    The goal definition is the first phase of an LCA and determines the purpose of a study in detail. This chapter teaches how to perform the six aspects of a goal definition: (1) Intended applications of the results, (2) Limitations due to methodological choices, (3) Decision context and reasons...... for carrying out the study, (4) Target audience , (5) Comparative studies to be disclosed to the public and (6) Commissioner of the study and other influential actors. The instructions address both the conduct and reporting of a goal definition and are largely based on the ILCD guidance document (EC...

  3. Ultimate and proximate explanations of strong reciprocity. (United States)

    Vromen, Jack


    Strong reciprocity (SR) has recently been subject to heated debate. In this debate, the "West camp" (West et al. in Evol Hum Behav 32(4):231-262, 2011), which is critical of the case for SR, and the "Laland camp" (Laland et al. in Science, 334(6062):1512-1516, 2011, Biol Philos 28(5):719-745, 2013), which is sympathetic to the case of SR, seem to take diametrically opposed positions. The West camp criticizes advocates of SR for conflating proximate and ultimate causation. SR is said to be a proximate mechanism that is put forward by its advocates as an ultimate explanation of human cooperation. The West camp thus accuses advocates of SR for not heeding Mayr's original distinction between ultimate and proximate causation. The Laland camp praises advocates of SR for revising Mayr's distinction. Advocates of SR are said to replace Mayr's uni-directional view on the relation between ultimate and proximate causes by the bi-directional one of reciprocal causation. The paper argues that both the West camp and the Laland camp misrepresent what advocates of SR are up to. The West camp is right that SR is a proximate cause of human cooperation. But rather than putting forward SR as an ultimate explanation, as the West camp argues, advocates of SR believe that SR itself is in need of ultimate explanation. Advocates of SR tend to take gene-culture co-evolutionary theory as the correct meta-theoretical framework for advancing ultimate explanations of SR. Appearances notwithstanding, gene-culture coevolutionary theory does not imply Laland et al.'s notion of reciprocal causation. "Reciprocal causation" suggests that proximate and ultimate causes interact simultaneously, while advocates of SR assume that they interact sequentially. I end by arguing that the best way to understand the debate is by disambiguating Mayr's ultimate-proximate distinction. I propose to reserve "ultimate" and "proximate" for different sorts of explanations, and to use other terms for distinguishing

  4. Therapeutic Drug Monitoring in Rheumatic Diseases

    Directory of Open Access Journals (Sweden)

    NG Hoi-Yan Alexandra


    Full Text Available The ultimate goal of treating rheumatic disease is to achieve rapid suppression of inflammation, while at the same time minimizing the toxicities from rheumatic drugs. Different patients have different individual pharmacokinetics that can affect the drug level. Moreover, different factors, such as renal function, age or even different underlying diseases, can affect the drug level. Therefore, giving the same dosage of drugs to different patients may result in different drug levels. This article will review the usefulness of therapeutic drug monitoring in maximizing drug efficacy, while reducing the risk of toxicities in Hydroxychloroquine, Mycophenolate Mofetil, Tacrolimus and Tumor Necrosis Factor inhibitors (TNF Inhibitors.

  5. Ultimate justification: Wittgenstein and medical ethics. (United States)

    Hughes, J


    Decisions must be justified. In medical ethics various grounds are given to justify decisions, but ultimate justification seems illusory and little considered. The philosopher Wittgenstein discusses the problem of ultimate justification in the context of general philosophy. His comments, nevertheless, are pertinent to ethics. From a discussion of Wittgensteinian notions, such as 'bedrock', the idea that 'ultimate' justification is grounded in human nature as such is derived. This discussion is relevant to medical ethics in at least five ways: it shows generally what type of certainty there is in practical ethics; it seems to imply some objective foundation to our ethical judgements; it squares with our experience of making ethical decisions; it shows something of the nature of moral arguments; and, finally, it has implications for teaching medicine and ethics.

  6. Librarians Are the Ultimate Knowledge Managers? (United States)

    Koina, Cathie


    Librarians are the ultimate knowledge managers. Everyone knows that. After all, haven't they been the custodians of documented knowledge for centuries? Who could possibly do it better than them? Well, then why aren't people knocking down their doors, begging them to be the knowledge managers of the organisation? Are they just ignorant of how…

  7. Industrial goals

    International Nuclear Information System (INIS)

    Martin, P.


    The aim of the third seminar on pellet-clad interaction, which held at Aix en Provence (France) from 9-11 march 2004, was to draw a comprehensive picture of current understanding of pellet clad interaction and its impact on the fuel rod under the widest possible conditions. This document provides the summaries of the five sessions: opening and industrial goals, fuel material behaviour in PCI situation, cladding behaviour relevant to PCI, in-pile rod behaviour, modelling of the mechanical interaction between pellet and cladding. (A.L.B.)

  8. Ultimate gradient in solid-state accelerators

    International Nuclear Information System (INIS)

    Whittum, D.H.


    The authors recall the motivation for research in high-gradient acceleration and the problems posed by a compact collider. They summarize the phenomena known to appear in operation of a solid-state structure with large fields, and research relevant to the question of the ultimate gradient. They take note of new concepts, and examine one in detail, a miniature particle accelerator based on an active millimeter-wave circuit and parallel particle beams

  9. The ultimate disposition of depleted uranium

    Energy Technology Data Exchange (ETDEWEB)

    Lemons, T.R. [Uranium Enrichment Organization, Oak Ridge, TN (United States)


    Depleted uranium (DU) is produced as a by-product of the uranium enrichment process. Over 340,000 MTU of DU in the form of UF{sub 6} have been accumulated at the US government gaseous diffusion plants and the stockpile continues to grow. An overview of issues and objectives associated with the inventory management and the ultimate disposition of this material is presented.

  10. Ultimate Strength of Ship Hulls under Torsion

    DEFF Research Database (Denmark)

    Paik, Jeom Kee; Thayamballi, Anil K.; Pedersen, Preben Terndrup


    For a ship hull with large deck openings such as container vessels and some large bulk carriers, the analysis of warping stresses and hatch opening deformations is an essential part of ship structural analyses. It is thus of importance to better understand the ultimate torsional strength characte......For a ship hull with large deck openings such as container vessels and some large bulk carriers, the analysis of warping stresses and hatch opening deformations is an essential part of ship structural analyses. It is thus of importance to better understand the ultimate torsional strength...... characteristics of ships with large hatch openings. The primary aim of the present study is to investigate the ultimate strength characteristics of ship hulls with large hatch openings under torsion. Axial (warping) as well as shear stresses are normally developed for thin-walled beams with open cross sections...... subjected to torsion. A procedure for calculating these stresses is briefly described. As an illustrative example, the distribution and magnitude of warping and shear stresses for a typical container vessel hull cross section under unit torsion is calculated by the procedure. By theoretical and numerical...

  11. The ultimate disposition of depleted uranium

    Energy Technology Data Exchange (ETDEWEB)


    Significant amounts of the depleted uranium (DU) created by past uranium enrichment activities have been sold, disposed of commercially, or utilized by defense programs. In recent years, however, the demand for DU has become quite small compared to quantities available, and within the US Department of Energy (DOE) there is concern for any risks and/or cost liabilities that might be associated with the ever-growing inventory of this material. As a result, Martin Marietta Energy Systems, Inc. (Energy Systems), was asked to review options and to develop a comprehensive plan for inventory management and the ultimate disposition of DU accumulated at the gaseous diffusion plants (GDPs). An Energy Systems task team, under the chairmanship of T. R. Lemons, was formed in late 1989 to provide advice and guidance for this task. This report reviews options and recommends actions and objectives in the management of working inventories of partially depleted feed (PDF) materials and for the ultimate disposition of fully depleted uranium (FDU). Actions that should be considered are as follows. (1) Inspect UF{sub 6} cylinders on a semiannual basis. (2) Upgrade cylinder maintenance and storage yards. (3) Convert FDU to U{sub 3}O{sub 8} for long-term storage or disposal. This will include provisions for partial recovery of costs to offset those associated with DU inventory management and the ultimate disposal of FDU. Another recommendation is to drop the term tails'' in favor of depleted uranium'' or DU'' because the tails'' label implies that it is waste.'' 13 refs.


    Directory of Open Access Journals (Sweden)

    Dejan Milenković


    Full Text Available The study included 60 young football players aged 10 and 11 years with the aim to examine the influence of motor skills on a specific accuracy in football. The following tests for assessment of motoric abilities were used: Coordination: jumping over the horizontal rope, envelope test, figure „8“ with bending; Flexibility: forward bend-standing upper-body rotation-touch, the splits, side-stepping with a baton; Balance: standing on one leg along the balance bench, standing on one leg with eyes closed, flamingo test. Tests for specific accuracy in football included: elevational accuracy by foot - vertical target, elevational accuracy by foot - horizontal target, linear accuracy by foot - vertical target, the hits of ball by foot on the wall after it rebounces from the surface, elevational accuracy by head - vertical target and elevational accuracy by head - horizontal target. Results obtained by processing the data applying canonical correlation and regression analysis indicated the indisputable influence of motor abilities of young football players on the majority of specific accuracy tests.

  13. Pharmaceutical care as the ultimate goal of the мodern pharmacist formation

    Directory of Open Access Journals (Sweden)

    O. V. Kraydashenko


    Full Text Available The World Health Organization (WHO has identified the current strategic direction of health care throughout the world as "Focus on the patient." Therefore, the pharmacist role in the healthcare system is changing - a pharmacist has a key role in public health. Pharmacist provides assistance to the patient and guarantees that assistance is designed correctly, effective among all the available options, is safe and right for this patient. Due to this the approaches to teaching students are changed significantly, it is necessary to create the clinical thinking in future pharmacists. The main objective in teaching pharmacotherapy and clinical pharmacy is training the pharmacist to have an adequate theoretical knowledge and practical skills to control the conduct of the most rational drug therapy in a concrete patient. Pharmacist must choose the appropriate therapy for a patient based on pharmacokinetics, pharmacodynamics, possible side effects and age, sex, presence of comorbidities of the patient. Practical sessions conducted directly in the clinic, include this organizational structure: The preparatory phase (organization and setting teaching purposes and motivations, control the output level of knowledge - tests, oral theoretical questions; The basic phase (formation of professional skills and knowledge to identify general principles of clinical pharmacy, work near a bed, definition of clinical syndromes, define treatment plan, analysis of the tests results, solving typical tasks and tests. The final phase – control of the the final level of knowledge and skills (solving atypical problems, writing prescriptions. We provided a special sense to the independent work of students on the preparation and wrote recommendation "The efficacy and safety protocol of medicines". Particular attention is paid to the following sections: medication and allergy history; pharmacotherapy; assessment of possible interactions of drugs; selecting assess the efficacy and safety of pharmacotherapy; daily logs of the dynamic control to the pharmacotherapy efficacy and safety. The important stage in the formation of clinical thinking in students is educational practice. During the practical training students should be familiar with the basics of deontology and the ethics of communication with pharmacies visitors; acquire skills of medicinal history collecting. Students are expected to acquire skills of choosing the optimal OTC medicine for a concrete patient and use to practice the algorithm of the distribution patients who need and do not need doctor consultation. Thus, an integrated approach to the teaching of pharmacotherapy, clinical pharmacy, practical training in clinical pharmacy, promotes the formation of clinical thinking in students.

  14. Ultimately short ballistic vertical graphene Josephson junctions (United States)

    Lee, Gil-Ho; Kim, Sol; Jhi, Seung-Hoon; Lee, Hu-Jong


    Much efforts have been made for the realization of hybrid Josephson junctions incorporating various materials for the fundamental studies of exotic physical phenomena as well as the applications to superconducting quantum devices. Nonetheless, the efforts have been hindered by the diffusive nature of the conducting channels and interfaces. To overcome the obstacles, we vertically sandwiched a cleaved graphene monoatomic layer as the normal-conducting spacer between superconducting electrodes. The atomically thin single-crystalline graphene layer serves as an ultimately short conducting channel, with highly transparent interfaces with superconductors. In particular, we show the strong Josephson coupling reaching the theoretical limit, the convex-shaped temperature dependence of the Josephson critical current and the exceptionally skewed phase dependence of the Josephson current; all demonstrate the bona fide short and ballistic Josephson nature. This vertical stacking scheme for extremely thin transparent spacers would open a new pathway for exploring the exotic coherence phenomena occurring on an atomic scale. PMID:25635386

  15. Ultimate-gradient accelerators physics and prospects

    CERN Document Server

    Skrinsky, Aleksander Nikolayevich


    As introduction, the needs and ways for ultimate acceleration gradients are discussed briefly. The Plasma Wake Field Acceleration is analized in the most important details. The structure of specific plasma oscillations and "high energy driver beam SP-plasma" interaction is presented, including computer simulation of the process. Some pratical ways to introduce the necessary mm-scale bunching in driver beam and to arrange sequential energy multiplication are dicussed. The influence of accelerating beam particle - plasma binary collisions is considered, also. As applications of PWFA, the use of proton super-colliders beams (LHC and Future SC) to drive the "multi particle types" accelerator, and the arrangements for the electron-positron TeV range collider are discussed.

  16. Ultimate load capacities of expansion anchor bolts

    International Nuclear Information System (INIS)

    Czarnecki, R.M.; Manrique, M.A.; Samaddar, S.K.


    A summary of available experimental expansion anchor bolt test data is presented. These data were collected as part of programs by the nuclear industry to address generic issues related to verification of seismic adequacy of equipment in nuclear power plants. Some of the data presented are suitable for use in seismic probabilistic risk assessments. For example, mean values of ultimate strength, along with their standard deviation and coefficients of variation, for a range of most typical expansion anchor bolt sizes are presented. Effects of interaction between shear and tension, edge distance, spacing, and cracking of the concrete are presented in a manner that is more suitable for use in deterministic evaluations. Related industry programs to derive anchor bolt capacities are briefly discussed. Recommendations for areas of further investigation are also presented

  17. Focused ion beam technology and ultimate applications

    International Nuclear Information System (INIS)

    Gierak, Jacques


    In this topical review, the potential of the focused ion beam (FIB) technology and ultimate applications are reviewed. After an introduction to the technology and to the operating principles of liquid metal ion sources (LMIS), of ion optics and instrument architectures, several applications are described and discussed. First, the application of FIB for microcircuit inspection, metrology and failure analysis is presented. Then, we introduce and illustrate some advanced patterning schemes we propose as next generation FIB processing examples. These patterning schemes are (i) local defect injection or smoothing in magnetic thin film direct patterning, (ii) functionalization of graphite substrates to guide organization of clusters, (iii) local and selective epitaxy of III–V semiconductor quantum dots and (iv) FIB patterned solid-state nanopores for biological molecules manipulation and analysis. We conclude this work by giving our vision of the future developments for FIB technology. (topical review)

  18. Transcending matter: physics and ultimate meaning. (United States)

    Paulson, Steve; Frank, Adam; Kaiser, David; Maudlin, Tim; Natarajan, Priyamvada


    From the discovery of new galaxies and nearly undetectable dark energy to the quantum entanglement of particles across the universe, new findings in physics naturally elicit a sense of awe and wonder. For the founders of modern physics-from Einstein and Bohr to Heisenberg, Pauli, and Bohm-a fascination with deeper questions of meaning and ultimate reality led some of them to explore esoteric traditions and metaphysics. More recently, however, physicists have largely shunned such philosophical and spiritual associations. What can contemporary physics offer us in the quest to understand our place in the universe? Has physics in some ways become a religion unto itself that rejects the search for existential meaning? Discussion of these and related questions is presented in this paper. © 2015 New York Academy of Sciences.

  19. UHS, Ultimate Heat Sink Cooling Pond Analysis

    International Nuclear Information System (INIS)

    Codell, R.; Nuttle, W.K.


    1 - Description of program or function: Three programs model performance of an ultimate heat sink cooling pond. National Weather Service data is read and analyzed to predict periods of lowest cooling performance and highest evaporative loss. The data is compared to local site data for significant differences. Then the maximum pond temperature is predicted. Five programs model performance of an ultimate heat sink spray pond. The cooling performance, evaporative water loss, and drift water loss as a function of wind speed are estimated for a spray field. These estimates are used in conjunction with National Weather Service data to predict periods of lowest cooling performance and highest evaporative loss. This data is compared to local site data for significant differences. Then the maximum pond temperature is predicted. 2 - Method of solution: The transfer of heat and water vapor is modeled using an equilibrium temperature procedure for an UHS cooling pond. The UHS spray pond model considers heat, mass, and momentum transfer from a single water drop with the surrounding air, and modification of the surrounding air resulting from the heat, mass, and momentum transfer from many drops in different parts of a spray field. 3 - Restrictions on the complexity of the problem: The program SPRCO uses RANF, a uniform random number generator which is an intrinsic function on the CDC. All programs except COMET use the NAMELIST statement, which is non standard. Otherwise these programs conform to the ANSI Fortran 77 standard. The meteorological data scanning procedure requires tens of years of recorded data to be effective. The models and methods, provided as useful tool for UHS analyses of cooling ponds and spray ponds, are intended as guidelines only. Use of these methods does not automatically assure NRC approval, nor are they required procedures for nuclear-power-plant licensing

  20. Wall roughness induces asymptotic ultimate turbulence (United States)

    Zhu, Xiaojue; Verschoof, Ruben A.; Bakhuis, Dennis; Huisman, Sander G.; Verzicco, Roberto; Sun, Chao; Lohse, Detlef


    Turbulence governs the transport of heat, mass and momentum on multiple scales. In real-world applications, wall-bounded turbulence typically involves surfaces that are rough; however, characterizing and understanding the effects of wall roughness on turbulence remains a challenge. Here, by combining extensive experiments and numerical simulations, we examine the paradigmatic Taylor-Couette system, which describes the closed flow between two independently rotating coaxial cylinders. We show how wall roughness greatly enhances the overall transport properties and the corresponding scaling exponents associated with wall-bounded turbulence. We reveal that if only one of the walls is rough, the bulk velocity is slaved to the rough side, due to the much stronger coupling to that wall by the detaching flow structures. If both walls are rough, the viscosity dependence is eliminated, giving rise to asymptotic ultimate turbulence—the upper limit of transport—the existence of which was predicted more than 50 years ago. In this limit, the scaling laws can be extrapolated to arbitrarily large Reynolds numbers.

  1. The ultimate challenge of cloacal exstrophy. (United States)

    Schober, Justine M; Carmichael, Polly A; Hines, Melissa; Ransley, Philip G


    Our review addresses the various system abnormalities associated with cloacal exstrophy and revisits the question of gender assignment. Gender assignment decisions and psychological aspects of gender issues have become the "ultimate challenge." Exploration of gender identity, gender role behavior and sexual orientation has just begun. A comprehensive literature review was performed with all world literature regarding the current management of cloacal exstrophy. Research focused on management principles, outcomes and documentation of concurrent anomalies. We also describe original research evaluating gender identity in our own series of patients raised as girls to illustrate the challenge of treatment and augment the available literature, which is scant. Abnormalities of the vertebral column ranged from hemivertebra to myelomeningocele. With magnetic resonance imaging, the incidence of spinal dysraphism approached 100% and cord tethering was also more frequently recognized. For children with the short bowel syndrome, advances in antibiotic usage, and parenteral and enteral nutrition have increased the survival rate and reduced morbidity. A neurological component has been recognized for bladder function, bladder neck continence, lower extremity function and erectile capacity. Mitrofanoff-type reconstruction with bladder neck closure and continent catheterizable stoma dramatically increased continence. Diminutive or absent penis has been documented in 30% of males, and no documentation of paternity exists. The majority of females have bicornuate uterus. However, ovaries and tubes were generally normal. No reports of proven fertility exist. The strategy and timing of surgery relating to gender assignment remain controversial. A desperate need exists for research focusing on gender development and quality of life. Until that time, a cautious watchful approach may be most appropriate as our patients with cloacal exstrophy mature into adulthood.

  2. Ultimate storage of thorium-bearing waste

    International Nuclear Information System (INIS)

    Ganser, B.


    The goal of this R and D project was to experimentally determine the release of the radioactive noble gas radon from thorium-bearing waste. For the experiments, three 200 litre waste forms have been prepared: One package consisting of inactive cement (for blank value determination), the second of cemented, radioactive sludge precipitate (for reference value determination), and the third of untreated sludge precipitate in a drum. The release rate measured on the reference package at room temperature is 3.1x10 10 Bq/a for Rn-220, and 2.4x10 6 Bq/a for Rn-222. The release rate from a drum under equal conditions is 4.1x10 8 Bq/a for Rn-220, and 2.1x10 6 Bq/a for Rn-222. (orig./RB) [de

  3. Update on therapeutic interventions for the management of achalasia. (United States)

    Gunasingam, Nishmi; Perczuk, Adam; Talbot, Michael; Kaffes, Arthur; Saxena, Payal


    Achalasia is a primary esophageal motility disorder. It is the absence of peristalsis in the esophageal body and inability of the lower esophageal sphincter to relax, which characterizes this rare condition. Its features typically include dysphagia, regurgitation, chest pain, and weight loss. The ultimate goal in treating achalasia is to relieve the patient's symptoms, improve esophageal emptying, and prevent further dilatation of the esophagus. Current treatment modalities targeted at achalasia include pharmacological therapy, endoscopic therapy, and surgery. This review focuses on the current therapeutic options and explores the role of peroral endoscopic myotomy in the management armamentarium. © 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

  4. DARWIN: towards the ultimate dark matter detector (United States)

    Aalbers, J.; Agostini, F.; Alfonsi, M.; Amaro, F. D.; Amsler, C.; Aprile, E.; Arazi, L.; Arneodo, F.; Barrow, P.; Baudis, L.; Benabderrahmane, M. L.; Berger, T.; Beskers, B.; Breskin, A.; Breur, P. A.; Brown, A.; Brown, E.; Bruenner, S.; Bruno, G.; Budnik, R.; Bütikofer, L.; Calvén, J.; Cardoso, J. M. R.; Cichon, D.; Coderre, D.; Colijn, A. P.; Conrad, J.; Cussonneau, J. P.; Decowski, M. P.; Diglio, S.; Drexlin, G.; Duchovni, E.; Erdal, E.; Eurin, G.; Ferella, A.; Fieguth, A.; Fulgione, W.; Gallo Rosso, A.; Di Gangi, P.; Di Giovanni, A.; Galloway, M.; Garbini, M.; Geis, C.; Glueck, F.; Grandi, L.; Greene, Z.; Grignon, C.; Hasterok, C.; Hannen, V.; Hogenbirk, E.; Howlett, J.; Hilk, D.; Hils, C.; James, A.; Kaminsky, B.; Kazama, S.; Kilminster, B.; Kish, A.; Krauss, L. M.; Landsman, H.; Lang, R. F.; Lin, Q.; Linde, F. L.; Lindemann, S.; Lindner, M.; Lopes, J. A. M.; Marrodán Undagoitia, T.; Masbou, J.; Massoli, F. V.; Mayani, D.; Messina, M.; Micheneau, K.; Molinario, A.; Morå, K. D.; Morteau, E.; Murra, M.; Naganoma, J.; Newstead, J. L.; Ni, K.; Oberlack, U.; Pakarha, P.; Pelssers, B.; de Perio, P.; Persiani, R.; Piastra, F.; Piro, M. C.; Plante, G.; Rauch, L.; Reichard, S.; Rizzo, A.; Rupp, N.; Dos Santos, J. M. F.; Sartorelli, G.; Scheibelhut, M.; Schindler, S.; Schumann, M.; Schreiner, J.; Scotto Lavina, L.; Selvi, M.; Shagin, P.; Silva, M. C.; Simgen, H.; Sissol, P.; von Sivers, M.; Thers, D.; Thurn, J.; Tiseni, A.; Trotta, R.; Tunnell, C. D.; Valerius, K.; Vargas, M. A.; Wang, H.; Wei, Y.; Weinheimer, C.; Wester, T.; Wulf, J.; Zhang, Y.; Zhu, T.; Zuber, K.


    DARk matter WImp search with liquid xenoN (DARWIN) will be an experiment for the direct detection of dark matter using a multi-ton liquid xenon time projection chamber at its core. Its primary goal will be to explore the experimentally accessible parameter space for Weakly Interacting Massive Particles (WIMPs) in a wide mass-range, until neutrino interactions with the target become an irreducible background. The prompt scintillation light and the charge signals induced by particle interactions in the xenon will be observed by VUV sensitive, ultra-low background photosensors. Besides its excellent sensitivity to WIMPs above a mass of 5 GeV/c2, such a detector with its large mass, low-energy threshold and ultra-low background level will also be sensitive to other rare interactions. It will search for solar axions, galactic axion-like particles and the neutrinoless double-beta decay of 136Xe, as well as measure the low-energy solar neutrino flux with detect galactic supernovae. We present the concept of the DARWIN detector and discuss its physics reach, the main sources of backgrounds and the ongoing detector design and R&D efforts.

  5. DARWIN: towards the ultimate dark matter detector

    Energy Technology Data Exchange (ETDEWEB)

    Aalbers, J.; Breur, P.A.; Brown, A. [Nikhef and the University of Amsterdam, Amsterdam (Netherlands); Agostini, F. [Department of Physics and Astrophysics, University of Bologna and INFN-Bologna, Bologna (Italy); Alfonsi, M.; Beskers, B. [Institut für Physik and Exzellenzcluster PRISMA, Johannes Gutenberg-Universität Mainz, Mainz (Germany); Amaro, F.D. [Department of Physics, University of Coimbra, Coimbra (Portugal); Amsler, C. [Albert Einstein Center for Fundamental Physics, Universität Bern, Bern (Switzerland); Aprile, E. [Physics Department, Columbia University, New York, NY (United States); Arazi, L.; Breskin, A.; Budnik, R. [Department of Particle Physics and Astrophysics, Weizmann Institute of Science, Rehovot (Israel); Arneodo, F.; Benabderrahmane, M.L. [New York University Abu Dhabi (United Arab Emirates); Barrow, P.; Baudis, L. [Physik-Institut, Universität Zürich, Zürich (Switzerland); Berger, T.; Brown, E. [Department of Physics, Applied Physics and Astronomy, Rensselaer Polytechnic Institute, Troy, NY (United States); Bruenner, S. [Max-Planck-Institut für Kernphysik, Heidelberg (Germany); Bruno, G., E-mail:, E-mail:, E-mail:, E-mail:, E-mail: [INFN-Laboratori Nazionali del Gran Sasso and Gran Sasso Science Institute, L' Aquila (Italy); and others


    DARk matter WImp search with liquid xenoN (DARWIN) will be an experiment for the direct detection of dark matter using a multi-ton liquid xenon time projection chamber at its core. Its primary goal will be to explore the experimentally accessible parameter space for Weakly Interacting Massive Particles (WIMPs) in a wide mass-range, until neutrino interactions with the target become an irreducible background. The prompt scintillation light and the charge signals induced by particle interactions in the xenon will be observed by VUV sensitive, ultra-low background photosensors. Besides its excellent sensitivity to WIMPs above a mass of 5 GeV/ c {sup 2}, such a detector with its large mass, low-energy threshold and ultra-low background level will also be sensitive to other rare interactions. It will search for solar axions, galactic axion-like particles and the neutrinoless double-beta decay of {sup 136}Xe, as well as measure the low-energy solar neutrino flux with < 1% precision, observe coherent neutrino-nucleus interactions, and detect galactic supernovae. We present the concept of the DARWIN detector and discuss its physics reach, the main sources of backgrounds and the ongoing detector design and R and D efforts.

  6. A comparison of international criteria for the ultimate storage of radioactive wastes

    International Nuclear Information System (INIS)

    Mielke, H.


    In countries other than the Federal Republic of Germany and internationally there are no comprehensive codes referring to criteria and safety requirements except those of the IAEA and USA. In other countries there exist safety goals for the ultimate storage or for purely geological criteria. The degree of detailing regulations differs widely abroad and internationally. Safety goals abroad and internationally as well as measures for their realisation in the ultimate storage of radioactive wastes in deep geological formations are in line with the German safety goals. The IAEA refers to general aspects of geological, waste technology and ultimate storage technology criteria. In the USA, ultimate storage technology criteria have been quantified in part. The quantitative geological criteria existing in Great Britain and in the Netherlands are only relevant in as much as safety analyses must be performed for a specific site to provide evidence for the safety of this site. The comparison shows that most requirements pronounced abroad are also made for the Federal Republic of Germany. Some requirements are more specified in the Federal Republic of Germany, some are more detailed abroad. (orig./HP) [de

  7. Prevalence of Obesity and Its Influence on Achievement of Cardiometabolic Therapeutic Goals in Chinese Type 2 Diabetes Patients: An Analysis of the Nationwide, Cross-Sectional 3B Study.

    NARCIS (Netherlands)

    Zhou, X.; Ji, L.; Ran, X.; Su, B.; Ji, Q.; Pan, C.; Weng, J.; Ma, C.; Hao, C.; Zhang, D.; Hu, D.


    BACKGROUND: There are few data on the prevalence of obesity and its influence on achieving blood glucose, blood pressure, and blood lipid (3B) goals in Chinese type 2 diabetes outpatients. METHODS: Patient demographic data, anthropometric measurements, medications, and blood glucose and lipid

  8. ZIO: The Ultimate Linux I/O Framework

    CERN Document Server

    Gonzalez Cobas, J D; Rubini, A; Nellaga, S; Vaga, F


    ZIO (with Z standing for “The Ultimate I/O” Framework) was developed for CERN with the specific needs of physics labs in mind, which are poorly addressed in the mainstream Linux kernel. ZIO provides a framework for industrial, high-bandwith, high-channel count I/O device drivers (digitizers, function generators, timing devices like TDCs) with performance, generality and scalability as design goals. Among its features, it offers abstractions for • both input and output channels, and channel sets • run-time selection of trigger types • run-time selection of buffer types • sysfs-based configuration • char devices for data and metadata • a socket interface (PF ZIO) as alternative to char devices In this paper, we discuss the design and implementation of ZIO, and describe representative cases of driver development for typical and exotic applications: drivers for the FMC (FPGAMezzanine Card, see [1]) boards developed at CERN like the FMC ADC 100Msps digitizer, FMC TDC timestamp counter, and FMC DEL ...

  9. Direct ultimate disposal of spent fuel DEAB. Systems analysis. Ultimate disposal concepts. Final report. Main volume

    International Nuclear Information System (INIS)

    Wahl, A.


    The results elaborated under the project, systems analysis of mixed radwaste disposal concepts and systems analysis of ultimate disposal concepts, provide a comprehensive description and assessment of a radwaste repository, for heat generating wastes and for wastes with negligible heat generation, and thus represent the knowledge basis for forthcoming planning work for a repository in an abandoned salt mine. A fact to be considered is that temperature field calculations have shown that there is room for further optimization with regard to the mine layout. The following aspects have been analysed: (1) safety of operation; (2) technical feasibility and realisation and licensability of the concepts; (3) operational aspects; (4) varieties of utilization of the salt dome for the intended purpose (boreholes for waste emplacement, emplacement in galleries, multi-horizon systems); (5) long-term structural stability of the mine; (6) economic efficiency; (7) nuclear materials safeguards. (orig./HP) [de

  10. Future Synchrotron Light Sources Based on Ultimate Storage Rings

    International Nuclear Information System (INIS)

    Cai, Yunhai


    The main purpose of this talk is to describe how far one might push the state of the art in storage ring design. The talk will start with an overview of the latest developments and advances in the design of synchrotron light sources based on the concept of an 'ultimate' storage ring. The review will establish how bright a ring based light source might be, where the frontier of technological challenges are, and what the limits of accelerator physics are. Emphasis will be given to possible improvements in accelerator design and developments in technology toward the goal of achieving an ultimate storage ring. An ultimate storage ring (USR), defined as an electron ring-based light source having an emittance in both transverse planes at the diffraction limit for the range of X-ray wavelengths of interest for a scientific community, would provide very high brightness photons having high transverse coherence that would extend the capabilities of X-ray imaging and probe techniques beyond today's performance. It would be a cost-effective, high-coherence 4th generation light source, competitive with one based on energy recovery linac (ERL) technology, serving a large number of users studying material, chemical, and biological sciences. Furthermore, because of the experience accumulated over many decades of ring operation, it would have the great advantage of stability and reliability. In this paper we consider the design of an USR having 10-pm-rad emittance. It is a tremendous challenge to design a storage ring having such an extremely low emittance, a factor of 100 smaller than those in existing light sources, especially such that it has adequate dynamic aperture and beam lifetime. In many ultra-low emittance designs, the injection acceptances are not large enough for accumulation of the electron beam, necessitating on-axis injection where stored electron bunches are completely replaced with newly injected ones. Recently, starting with the MAX-IV 7-bend achromatic cell, we

  11. Future Synchrotron Light Sources Based on Ultimate Storage Rings

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Yunhai; /SLAC


    The main purpose of this talk is to describe how far one might push the state of the art in storage ring design. The talk will start with an overview of the latest developments and advances in the design of synchrotron light sources based on the concept of an 'ultimate' storage ring. The review will establish how bright a ring based light source might be, where the frontier of technological challenges are, and what the limits of accelerator physics are. Emphasis will be given to possible improvements in accelerator design and developments in technology toward the goal of achieving an ultimate storage ring. An ultimate storage ring (USR), defined as an electron ring-based light source having an emittance in both transverse planes at the diffraction limit for the range of X-ray wavelengths of interest for a scientific community, would provide very high brightness photons having high transverse coherence that would extend the capabilities of X-ray imaging and probe techniques beyond today's performance. It would be a cost-effective, high-coherence 4th generation light source, competitive with one based on energy recovery linac (ERL) technology, serving a large number of users studying material, chemical, and biological sciences. Furthermore, because of the experience accumulated over many decades of ring operation, it would have the great advantage of stability and reliability. In this paper we consider the design of an USR having 10-pm-rad emittance. It is a tremendous challenge to design a storage ring having such an extremely low emittance, a factor of 100 smaller than those in existing light sources, especially such that it has adequate dynamic aperture and beam lifetime. In many ultra-low emittance designs, the injection acceptances are not large enough for accumulation of the electron beam, necessitating on-axis injection where stored electron bunches are completely replaced with newly injected ones. Recently, starting with the MAX-IV 7-bend

  12. Ultimate Educational Aims, Overridingness, and Personal Well-Being (United States)

    Haji, Ishtiyaque; Cuypers, Stefaan E.


    Discussion regarding education's aims, especially its ultimate aims, is a key topic in the philosophy of education. These aims or values play a pivotal role in regulating and structuring moral and other types of normative education. We outline two plausible strategies to identify and justify education's ultimate aims. The first associates these…

  13. Sensitivity analysis on ultimate strength of aluminium stiffened panels

    DEFF Research Database (Denmark)

    Rigo, P.; Sarghiuta, R.; Estefen, S.


    This paper presents the results of an extensive sensitivity analysis carried out by the Committee III.1 "Ultimate Strength" of ISSC?2003 in the framework of a benchmark on the ultimate strength of aluminium stiffened panels. Previously, different benchmarks were presented by ISSC committees on ul...

  14. Ultimate Lateral Capacity of Rigid Pile in c- φ Soil (United States)

    Zhang, Wei-min


    To date no analytical solution of the pile ultimate lateral capacity for the general c- φ soil has been obtained. In the present study, a new dimensionless embedded ratio was proposed and the analytical solutions of ultimate lateral capacity and rotation center of rigid pile in c- φ soils were obtained. The results showed that both the dimensionless ultimate lateral capacity and dimensionless rotation center were the univariate functions of the embedded ratio. Also, the ultimate lateral capacity in the c- φ soil was the combination of the ultimate lateral capacity ( f c ) in the clay, and the ultimate lateral capacity ( f φ ) in the sand. Therefore, the Broms chart for clay, solution for clay ( φ=0) put forward by Poulos and Davis, solution for sand ( c=0) obtained by Petrasovits and Awad, and Kondner's ultimate bending moment were all proven to be the special cases of the general solution in the present study. A comparison of the field and laboratory tests in 93 cases showed that the average ratios of the theoretical values to the experimental value ranged from 0.85 to 1.15. Also, the theoretical values displayed a good agreement with the test values.

  15. Goals are not selfish. (United States)

    von Hippel, William; von Hippel, Frank A


    The metaphor of selfish goals is misguided. Organisms can be considered vessels that further the interests of their genes, but not vessels that further the interests of their goals. Although goals can act at cross-purposes to each other and to longevity, such trade-offs are predicted by evolutionary theory. The metaphor of selfish goals provides no purchase on this problem.

  16. Comparing Three Models of Achievement Goals: Goal Orientations, Goal Standards, and Goal Complexes (United States)

    Senko, Corwin; Tropiano, Katie L.


    Achievement goal theory (Dweck, 1986) initially characterized mastery goals and performance goals as opposites in a good-bad dualism of student motivation. A later revision (Harackiewicz, Barron, & Elliot, 1998) contended that both goals can provide benefits and be pursued together. Perhaps both frameworks are correct: Their contrasting views…

  17. Assessment of patient knowledge of diabetic goals, self-reported medication adherence, and goal attainment

    Directory of Open Access Journals (Sweden)

    Whitley HP


    Full Text Available Background: Medication adherence is an integral aspect of disease state management for patients with chronic illnesses, including diabetes mellitus. It has been hypothesized that patients with diabetes who have poor medication adherence may have less knowledge of overall therapeutic goals and may be less likely to attain these goals. Objective: The purpose of this study was to assess self-reported medication adherence, knowledge of therapeutic goals (hemoglobin A1C [A1C], low density lipoprotein cholesterol [LDL-C] and blood pressure [BP], and goal attainment in adult patients with diabetes. Methods: A survey was created to assess medication adherence, knowledge of therapeutic goals, and goal attainment for adult patients with diabetes followed at an internal medicine or a family medicine clinic. Surveys were self-administered prior to office visits. Additional data were collected from the electronic medical record. Statistical analysis was performed. Results: A total of 149 patients were enrolled. Knowledge of therapeutic goals was reported by 14%, 34%, and 18% of survived patients for LDL-C, BP, and A1C, respectively. Forty-six percent, 37%, and 40% of patients achieved LDL-C, BP, and A1C goals, respectively. Low prescribing of cholesterol-lowering medications was an interesting secondary finding; 36% of patients not at LDL-C goal had not been prescribed a medication targeted to lower cholesterol. Forty-eight percent of patients were medication non-adherent; most frequently reported reasons for non-adherence were forgot (34% and too expensive (14%. Patients at A1C goal were more adherent than patients not at goal (p=0.025. Conclusion: The majority did not reach goals and were unknowledgeable of goals; however, most were provided prescriptions to treat these parameters. Goal parameters should be revisited often amongst multidisciplinary team members with frequent and open communications. Additionally, it is imperative that practitioners discuss

  18. Influence of initial imperfections on ultimate strength of spherical shells

    Directory of Open Access Journals (Sweden)

    Chang-Li Yu


    Full Text Available Comprehensive consideration regarding influence mechanisms of initial imperfections on ultimate strength of spherical shells is taken to satisfy requirement of deep-sea structural design. The feasibility of innovative numerical procedure that combines welding simulation and non-linear buckling analysis is verified by a good agreement to experimental and theoretical results. Spherical shells with a series of wall thicknesses to radius ratios are studied. Residual stress and deformations from welding process are investigated separately. Variant influence mechanisms are discovered. Residual stress is demonstrated to be influential to stress field and buckling behavior but not to the ultimate strength. Deformations are proved to have a significant impact on ultimate strength. When central angles are less than critical value, concave magnitudes reduce ultimate strengths linearly. However, deformations with central angles above critical value are of much greater harm. Less imperfection susceptibility is found in spherical shells with larger wall thicknesses to radius ratios.

  19. Ultimate guide to YouTube for business

    CERN Document Server


    Ultimate Guide to YouTube for Business helps small business owners create marketing videos to help promote their products, share their story, build a community around their brand without spending a fortune-all the while making money.

  20. Ultimate Opening Combined with Area Stability Applied to Urban Scenes


    Marcotegui , Beatriz; Serna , Andrés; Hernández , Jorge


    International audience; This paper explores the use of ultimate opening in urban analysis context. It demonstrates the efficiency of this approach for street level elevation images, derived from 3D point clouds acquired by terrestrial mobile mapping systems. An area-stability term is introduced in the residual definition, reducing the over-segmentation of the vegetation while preserving small significant regions. We compare two possible combinations of the Ultimate Opening and the Area Stabil...

  1. Direct ultimate disposal - state of investigations and prospects

    International Nuclear Information System (INIS)

    Gasterstaedt, N.


    Based on a decision adopted by the Prime Ministers on 25/10/90, the principles governing preventive waste management of nuclear power plants are reviewed. Increasing importance is attached to the direct ultimate disposal alternative. The legal and political framework, the technology involved, the state of developments, future activities under the R and D programme as well as a cost estimate of direct ultimate disposal are presented. (orig.) [de

  2. Assessment and characterization of radioactive waste for ultimate storage

    International Nuclear Information System (INIS)

    Brennecke, P.; Warnecke, E.


    The waste specifications determined from site safety analyses define the requirements to be met by waste forms for ultimate storage. Product quality control is the process step ensuring compliance with the conditions to be met for ultimate storage. For this purpose, radionuclide inventory, fixation method, container type, waste form and quantity, and type of waste are the most significant items on the checking list. (DG) [de

  3. Academic goals in surgery. (United States)

    Bleier, Joshua I S; Kann, Brian


    The development of an academic surgical career can be an overwhelming prospect, and one that is not intuitive. Establishing a structured plan and support structure is critical to success. Starting a successful academic surgical career begins with defining one's academic goals within several broad categories: personal goals, academic goals, research goals, educational goals, and financial goals. Learning the art of self-promotion is the means by which many of these goals are achieved. It is important to realize that achieving these goals requires a delicate personal balance between work and home life, and the key ways in which to achieve success require establishment of well thought-out goals, a reliable support structure, realistic and clear expectations, and frequent re-evaluation.

  4. Ultimate - a new generation of gasoline and diesel fuels; Ultimate - eine neue Generation von Otto- und Dieselkraftstoffen

    Energy Technology Data Exchange (ETDEWEB)

    Strempel, G. [Aral Forschung/Global Fuels Technology, Bochum (Germany); Beckwith, P. [BP Fuels Management Group, Pangbourne (United Kingdom); Froehling, J. [Aral Forschung, Bochum (Germany). Labor/Analytik; Baron, U. [Aral Forschung, Bochum (Germany). Motor- und Fahrzeuglaboratorium; Sauermann, P.; Balfanz, U. [Aral Forschung, Bochum (Germany). Produktentwicklung; Doermer, W. [Aral Forschung, Bochum (Germany). Produktqualitaet


    With the launch of Ultimate 100 gasoline and Ultimate Diesel, motorists in Germany now have the opportunity to choose new advanced performance fuels designed to get the very best from their engines. This article gives details of the technical development behind these fuels, their wide range of benefits, and how it is possible to manufacture fuels which meet the considerable technical challenge of achieving both more performance and less pollution. (orig.)

  5. Goals and Psychological Accounting

    DEFF Research Database (Denmark)

    Koch, Alexander Karl; Nafziger, Julia

    We model how people formulate and evaluate goals to overcome self-control problems. People often attempt to regulate their behavior by evaluating goal-related outcomes separately (in narrow psychological accounts) rather than jointly (in a broad account). To explain this evidence, our theory...... of endogenous narrow or broad psychological accounts combines insights from the literatures on goals and mental accounting with models of expectations-based reference-dependent preferences. By formulating goals the individual creates expectations that induce reference points for task outcomes. These goal......-induced reference points make substandard performance psychologically painful and motivate the individual to stick to his goals. How strong the commitment to goals is depends on the type of psychological account. We provide conditions when it is optimal to evaluate goals in narrow accounts. The key intuition...


    Directory of Open Access Journals (Sweden)

    Mladen Hudec


    Full Text Available The most questionable are the values of pressures between rock and support resulting from common deformations on the contact area between rock and support. Therefore the modelling and design of the tunnel support is not reliable, if it is based on active rock pressure resulting from this common deformations. The inversion of the design procedure is proposed. Instead of the active extreme pressure of the rock on support, the influence of ultimate reaction of the support on the rock has to be analysed. This procedure can be performed using the ultimate load principle, as proposed by Eurocodc 7 (Geotechnies. Normally, the rock has the tendency to increase the common conver¬gence until the support reaches its ultimate state. So, loading of profile boundary with the ultimate possible reaction of the support is very plausible. The reactive support pressures have to be probable and itself in equilibrium. The ultimate reactive load has to be reduced by Euro-code safety factor for structural elements and applied on the rock with given properties, or alternatively (as proposed by Eurocode 7 the soil or rock properties have to be diminished and calculated with full ultimate support pressures. If the rock with given (or proposed pro¬perties and loaded with ultimate reactive pressures resulting from supposed support, satisfy its failure criterion, then is the compound system support-rock verificatcd. By this procedure, the number of relevant material properties is reduce to the primary stress ratio and the constants defining the failure criterion. The verification can be performed by any of numerical methods, but we prefer here used boundary elements method (the paper is published in Croatian.

  7. Classification of radioactive waste and determination of waste specifications as well as conditions of acceptance for ultimate storage

    International Nuclear Information System (INIS)

    Merz, E.


    The determination of waste specification and conditions of acceptance must follow a certain scheme, the basics of which will be presented. First the types of waste and the ultimate storage facilities will be characterized. The various categories of waste will be listed in a universally valid system, and the preliminary conditioning options will be determined. Based on the results of safety analysis taking into account the whole system - geological circumstances, ultimate store mines, types and forms of waste - specifications for the various ultimate store products are to be derived following iterative methods. Suggestions though not of a binding nature and probably subject to eventual revisions in part will be presented. To ensure the safety goals, i.e. the exclusion of radioactivity from the human biosphere, appropriate quality control is required concerning the production and the acceptance at the ultimate store. The guiding principles to be heeded will be discussed in brief. (orig./HP) [de

  8. Ultimate load capacity assessment of reinforced concrete shell structures

    International Nuclear Information System (INIS)

    Gupta, Amita; Singh, R.K.; Kushwaha, H.S.; Mahajan, S.C.; Kakodkar, A.


    The objective of this study is to develop capability for prediction of ultimate load capacity of reinforced concrete shell structures. The present finite element code ULCA (Ultimate Load Capacity Assessment) adopts a degenerate concept of formulating general isoparametric shell element with a layered approach in the thickness direction. Different failure modes such as crushing, tensile cracking and reinforcement yielding are recognised for various problems. The structure fails by crushing of concrete when the concrete strain/stress reaches the ultimate stress or strain of concrete. Material nonlinearities as a result of tension cracking, tension stiffening between reinforcement and concrete in cracked region and yielding of reinforcement are considered along with geometric nonlinearity. Thus with this code it is possible to predict the pressure at which the first cracking, first through thickness cracking, first yielding of reinforcement occurs. After validating the code with few bench mark problems for different failure modes a reinforced concrete nuclear containment is analysed for its ultimate capacity and the results are matched with the published results. Further the ultimate load capacity of outer containment wall of Narora Atomic Power Station is predicted. It is observed that containment fails in membrane region and has a sufficient margin against design pressure. (author). 9 refs., 56 figs., 3 tabs., 1 appendix with 4 tabs

  9. Ductility and Ultimate Capacity of Prestressed Steel Reinforced Concrete Beams

    Directory of Open Access Journals (Sweden)

    Chengquan Wang


    Full Text Available Nonlinear numerical analysis of the structural behaviour of prestressed steel reinforced concrete (PSRC beams was carried out by using finite element analysis software ABAQUS. By comparing the load-deformation curves, the rationality and reliability of the finite element model have been confirmed; moreover, the changes of the beam stiffness and stress in the forcing process and the ultimate bearing capacity of the beam were analyzed. Based on the model, the effect of prestressed force, and H-steel to the stiffness, the ultimate bearing capacity and ductility of beam were also analyzed.

  10. Ultimate load model test for Sizewell 'B' primary containment

    International Nuclear Information System (INIS)

    Crowder, R.


    This paper considers the factors influencing the adoption of an ultimate load factor for the Sizewell 'B' PWR primary containment structure. As part of the validation process for the ultimate load analysis method, a proposal has been made by Nuclear Design Associates to build and test a 1/10th scale model of the containment structure, which would proceed following the granting of section 2 consent for Sizewell 'B'. The modelling principles, construction method and test proposals are examined in some detail. The proposal is currently being considered by the CEGB's Project Management Team. (author)

  11. Ultimate pressure capacity of CANDU 6 containment structures

    International Nuclear Information System (INIS)

    Radulescu, J.P.; Pradolin, L.; Mamet, J.C.


    This paper summarizes the analytical work carried out and the results obtained when determining the ultimate pressure capacity (UPC) of the containment structures of CANDU 6 nuclear power plants. The purpose of the analysis work was to demonstrate that such containment structures are capable of meeting design requirements under the most severe accident conditions. For this concrete vessel subjected to internal pressure, the UPC was defined as the pressure causing through cracking in the concrete. The present paper deals with the overall behaviour of the containment. The presence of openings, penetrations and the ultimate pressure of the airlocks were considered separately. (author)

  12. ''Project Crystal'' for ultimate storage of highly radioactive waste

    International Nuclear Information System (INIS)



    NAGRA (The National Association for storage of radioactive waste) in Baden has launched in North Switzerland an extensive geological research program. The current research program, under the title of ''Project Crystal'', aims at providing the scientific knowledge which is required for the assessment of the suitability of the crystalline sub-soil of North Switzerland for the ultimate storage of highly radioactive waste. Safety and feasibility of such ultimate storage are in the forefront of preoccupations. Scientific institutes of France, Germany, USA and Canada are cooperating more particularly on boring research and laboratory analyses. Technical data are given on the USA and German installations used. (P.F.K.)

  13. Trump er gældsøkonomiens ultimative illusionist

    DEFF Research Database (Denmark)

    Nielsen, Peter


    Trump giver ikke kun gevaldige skattelettelser og nærer en illusion om, at vækst vil løse alle problemer. Han fortrænger også gældsøkonomiens ultimative bundlinje i form af klimaforandringerne.......Trump giver ikke kun gevaldige skattelettelser og nærer en illusion om, at vækst vil løse alle problemer. Han fortrænger også gældsøkonomiens ultimative bundlinje i form af klimaforandringerne....

  14. Therapeutic goals in the treatment of Gaucher disease

    NARCIS (Netherlands)

    Pastores, Gregory M.; Weinreb, Neal J.; Aerts, Hans; Andria, Generoso; Cox, Timothy M.; Giralt, Manuel; Grabowski, Gregory A.; Mistry, Pramod K.; Tylki-Szymańska, Anna


    Gaucher disease, the most common lysosomal storage disorder, is a heterogeneous multisystem condition. Patients with non-neuronopathic (type 1) Gaucher disease may suffer from hepatomegaly, splenomegaly, thrombocytopenia, bleeding tendencies, anemia, hypermetabolism, skeletal pathology, growth

  15. Toward the ultimate goal of tritium self-sufficiency: Technical issues and requirements imposed on ARIES advanced power plants

    International Nuclear Information System (INIS)

    El-Guebaly, Laila A.; Malang, Siegfried


    Due to the lack of external tritium sources, all fusion power plants must demonstrate a closed tritium fuel cycle. The tritium breeding ratio (TBR) must exceed unity by a certain margin. The key question is: how large is this margin and how high should the calculated TBR be? The TBR requirement is design and breeder-dependent and evolves with time. At present, the ARIES requirement is 1.1 for the calculated overall TBR of LiPb systems. The Net TBR during plant operation could be around 1.01. The difference accounts for deficiencies in the design elements (nuclear data evaluation, neutronics code validation, and 3D modeling tools). Such a low Net TBR of 1.01 is potentially achievable in advanced designs employing advanced physics and technology. A dedicated R and D effort will reduce the difference between the calculated TBR and Net TBR. A generic breeding issue encountered in all fusion designs is whether any fusion design will over-breed or under-breed during plant operation. To achieve the required Net TBR with sufficient precision, an online control of tritium breeding is highly recommended for all fusion designs. This can easily be achieved for liquid breeders through online adjustment of Li enrichment.

  16. Ultimate deformation capacity of reinforced concrete slabs underblast load

    NARCIS (Netherlands)

    Doormaal, J.C.A.M. van; Weerheijm, J.


    In this paper a test method to determine the deformation capacity and the resistance-deformation curve of blast-loaded slabs is described. This method was developed at TNO-PML. The method has been used to determine the ultimate deformation capacity of some simply supported reinforced concrete slabs

  17. 49 Stories That Make an Ultimate STEM Lesson Plan (United States)

    Mehta, Swati; Mehta, Rohit; Berzina-Pitcher, Inese; Seals, Christopher; Mishra, Punya


    In this paper we reviewed what 49 large urban public school district STEM teachers enrolled in a year-long graduate certificate and fellowship program at a large Midwestern university considered as their amazing teaching moments. They were asked to share their amazing teaching moments that would make an Ultimate Lesson Plan in STEM. In smaller…

  18. Ultimate capabilities of soft x-ray optics

    International Nuclear Information System (INIS)

    Vinogradov, A.V.; Zorev, N.N.; Kozhevnikov, I.V.


    Nonimaging soft X-ray optics is examined. The ultimate capabilities of a number of X-ray optical components designed for concentration and collimation of radiation from point sources are determined. The applications of X-ray optics are discussed together with the properties of materials in the X-ray range

  19. Safety related aspects of ultimate disposal of radioactive wastes

    International Nuclear Information System (INIS)

    Goemmel, R.


    Solutions and questions related to nuclear waste management are presented. In particular, long-term safety of repositories in Germany and Sweden is considered, with special attention being paid to methods of detection, geotechnical barriers and post-operational phase of salt dome repositories, and conditioning of wastes to make them fit for ultimate disposal. (DG) [de

  20. Analysis of ultimate-heat-sink spray ponds. Technical report

    International Nuclear Information System (INIS)

    Codell, R.


    This report develops models which can be utilized in the design of certain types of spray ponds used in ultimate heat sinks at nuclear power plants, and ways in which the models may be employed to determine the design basis required by U.S. Nuclear Regulatory Commission Regulatory Guide 1.27

  1. Ultimate internal pressure capacity of concrete containment structures

    International Nuclear Information System (INIS)

    Krishnaswamy, C.N.; Namperumal, R.; Al-Dabbagh, A.


    Lesson learned from the accident at Three-Mile Island nuclear plant has necessitated the computation of the ultimate internal pressure capacity of containment structures as a licensing requirement in the U.S. In general, a containment structure is designed to be essentially elastic under design accident pressure. However, as the containment pressure builds up beyond the design value due to a more severe postulated accident, the containment response turns nonlinear as it sequentially passes through cracking of concrete, yielding of linear plate, yielding of rebar, and yielding of post-tensioning tendon (if the containment concrete is prestressed). This paper reports on the determination of the ultimate internal pressure capacity and nonlinear behavior of typical reinforced and prestressed concrete BWR containments. The probable modes of failure, the criteria for ultimate pressure capacity, and the most critical sections are described. Simple equations to hand-calculate the ultimate pressure capacity and the nonlinear behavior at membrane sections of the containment shell are presented. A nonlinear finite element analysis performed to determine the nonlinear behavior of the entire shell including nonmembrane sections is briefly discribed. The analysis model consisted of laminated axisymmetric shell finite elements with nonlinear stress-strain properties for each material. Results presented for typical BWR concrete containments include nonlinear response plots of internal pressure versus containment deflection and strains in the liner, rebar, and post-tensioning tendons at the most stressed section in the shell. Leak-tightness of the containment liner and the effect of thermal loads on the ultimate capacity are discussed. (orig.)

  2. Macromolecular therapeutics. (United States)

    Yang, Jiyuan; Kopeček, Jindřich


    This review covers water-soluble polymer-drug conjugates and macromolecules that possess biological activity without attached low molecular weight drugs. The main design principles of traditional and backbone degradable polymer-drug conjugates as well as the development of a new paradigm in nanomedicines - (low molecular weight) drug-free macromolecular therapeutics are discussed. To address the biological features of cancer, macromolecular therapeutics directed to stem/progenitor cells and the tumor microenvironment are deliberated. Finally, the future perspectives of the field are briefly debated. Copyright © 2014 Elsevier B.V. All rights reserved.

  3. Setting goals in psychotherapy

    DEFF Research Database (Denmark)

    Emiliussen, Jakob; Wagoner, Brady


    The present study is concerned with the ethical dilemmas of setting goals in therapy. The main questions that it aims to answer are: who is to set the goals for therapy and who is to decide when they have been reached? The study is based on four semi-­‐structured, phenomenological interviews...

  4. Tougher containment design goals

    International Nuclear Information System (INIS)

    O'Farrelly, C.


    Present day LWR containment design goals are reviewed, together with their potential failure modes. Rasmussen's estimates of failure probabilities are discussed and the concept of ''delayed failure'' is seen to be a valuable safety goal for hypothetical accidents. The paper investigates the inherent coremelt resistance capability of various containment designs and suggests improvements, with special emphasis on increasing the failure delay times. (author)

  5. Shared goals and development

    DEFF Research Database (Denmark)

    Blomberg, Olle


    undemanding for children to engage in, and therefore has the potential to play a part in fostering their understanding of other minds. Part of the functional role of shared goals is to enable agents to choose means that are appropriate to realising a goal with others rather than individually. By offering...

  6. Motivational Goal Bracketing

    DEFF Research Database (Denmark)

    Nafziger, Julia; Koch, Alexander

    It is a puzzle why people often evaluate consequences of choices separately (narrow bracketing) rather than jointly (broad bracketing). We study the hypothesis that a present-biased individual, who faces two tasks, may bracket his goals narrowly for motivational reasons. Goals motivate because th...... of the tasks. Narrow goals have a stronger motivational force and thus can be optimal. In particular, if one task outcome becomes known before working on the second task, narrow bracketing is always optimal.......It is a puzzle why people often evaluate consequences of choices separately (narrow bracketing) rather than jointly (broad bracketing). We study the hypothesis that a present-biased individual, who faces two tasks, may bracket his goals narrowly for motivational reasons. Goals motivate because...

  7. Therapeutic Nanodevices (United States)

    Lee, Stephen; Ruegsegger, Mark; Barnes, Philip; Smith, Bryan; Ferrari, Mauro

    Therapeutic nanotechnology offers minimally invasive therapies with high densities of function concentrated in small volumes, features that may reduce patient morbidity and mortality. Unlike other areas of nanotechnology, novel physical properties associated with nanoscale dimensionality are not the raison d'être of therapeutic nanotechnology, whereas the aggregation of multiple biochemical (or comparably precise) functions into controlled nanoarchitectures is. Multifunctionality is a hallmark of emerging nanotherapeutic devices, and multifunctionality can allow nanotherapeutic devices to perform multistep work processes, with each functional component contributing to one or more nanodevice subroutine such that, in aggregate, subroutines sum to a cogent work process. Cannonical nanotherapeutic subroutines include tethering (targeting) to sites of disease, dispensing measured doses of drug (or bioactive compound), detection of residual disease after therapy and communication with an external clinician/operator. Emerging nanotherapeutics thus blur the boundaries between medical devices and traditional pharmaceuticals. Assembly of therapeutic nanodevices generally exploits either (bio)material self-assembly properties or chemoselective bioconjugation techniques, or both. Given the complexity, composition, and the necessity for their tight chemical and structural definition inherent in the nature of nanotherapeutics, their cost of goods (COGs) might exceed that of (already expensive) biologics. Early therapeutic nanodevices will likely be applied to disease states which exhibit significant unmet patient need (cancer and cardiovascular disease), while application to other disease states well-served by conventional therapy may await perfection of nanotherapeutic design and assembly protocols.

  8. Treatment goals of pulmonary hypertension.

    LENUS (Irish Health Repository)

    McLaughlin, Vallerie V


    With significant therapeutic advances in the field of pulmonary arterial hypertension, the need to identify clinically relevant treatment goals that correlate with long-term outcome has emerged as 1 of the most critical tasks. Current goals include achieving modified New York Heart Association functional class I or II, 6-min walk distance >380 m, normalization of right ventricular size and function on echocardiograph, a decreasing or normalization of B-type natriuretic peptide (BNP), and hemodynamics with right atrial pressure <8 mm Hg and cardiac index >2.5 mg\\/kg\\/min(2). However, to more effectively prognosticate in the current era of complex treatments, it is becoming clear that the "bar" needs to be set higher, with more robust and clearer delineations aimed at parameters that correlate with long-term outcome; namely, exercise capacity and right heart function. Specifically, tests that accurately and noninvasively determine right ventricular function, such as cardiac magnetic resonance imaging and BNP\\/N-terminal pro-B-type natriuretic peptide, are emerging as promising indicators to serve as baseline predictors and treatment targets. Furthermore, studies focusing on outcomes have shown that no single test can reliably serve as a long-term prognostic marker and that composite treatment goals are more predictive of long-term outcome. It has been proposed that treatment goals be revised to include the following: modified New York Heart Association functional class I or II, 6-min walk distance ≥ 380 to 440 m, cardiopulmonary exercise test-measured peak oxygen consumption >15 ml\\/min\\/kg and ventilatory equivalent for carbon dioxide <45 l\\/min\\/l\\/min, BNP level toward "normal," echocardiograph and\\/or cardiac magnetic resonance imaging demonstrating normal\\/near-normal right ventricular size and function, and hemodynamics showing normalization of right ventricular function with right atrial pressure <8 mm Hg and cardiac index >2.5 to 3.0 l\\/min\\/m(2).

  9. Cable tray ultimate strength test employing a large shaker table

    Energy Technology Data Exchange (ETDEWEB)

    Komatsu, K.; Myojin, K.; Imai, K. [The Kansai Electric Power Co., Osaka (Japan); Fuyama, H. [Mitsubishi Heavy Industries Ltd, Takasago (Japan); Kokubo, E. [Mitsubishi Heavy Industdries Ltd, Kobe (Japan)


    Ultimate behaviors of cable trays, used in nuclear plants, have not been well studied since cable trays are designed based on conservative design criteria. In this study, by employing a large shaker table, an ultimate strength test was conducted for cable trays used in nuclear power plants. This report describes the results of shaker table test. The following results were obtained. First, in an S{sub 2} earthquake, the damping ratio was so large - more than 30% due to the rubbing of cables - that a large response was not present and the strains in the support were within the elastic limits. Secondly, the support was strong enough to sustain the cable trays even when the strain in the support was 20 times larger than the elastic limit. (authors)

  10. Landau damping: the mechanics model and its ultimate entropy gain

    International Nuclear Information System (INIS)

    Hannay, J H; Kluge, Michel


    Classical mechanics has only been invoked to account for Landau damping in a rather half-hearted way, alongside plasma perturbation theory. In particular this invocation is essential for the study of the saturation, or post-linear (or 'nonlinear') regime of the damping initiated by Dawson and O'Neill. By embracing mechanics wholeheartedly here, with its attendant phase space, one can access results, old and new, cleanly and directly, and with one fewer numerical integration for the post-linear regime. By using a summation technique familiar in semiclassical quantum mechanics (Poisson summation), the one remaining numerical integration can be much improved in accuracy. Also accessible from mechanics is the ultimate entropy gain. Though zero for any finite time (in the absence of coarse graining), the entropy gain is ultimately non-zero (at infinite time the required coarse graining is zero). It is calculated analytically by using the appropriate asymptotics, hitherto not fully exploited.

  11. Management and ultimate storage of wastes from nuclear power generation

    International Nuclear Information System (INIS)


    The annotation on R and D prorgam 86 parts I-II have been brought together in the present report part I, together with some general viewpoints, and been classified according to subject. Part II of the present report comprises viewpoints of 'Research Program 1987-1992' and part III of 'Alternative methods of ultimate storage'. Swedish and French viewpoints are presented in Swedish, the remaining foreign material in English. The comments are grouped in subject catergories. (O.S.)

  12. Ultimate Gradient Limitation in Niobium Superconducting Accelerating Cavities

    Energy Technology Data Exchange (ETDEWEB)

    Checchin, Mattia [Illinois Inst. of Technology, Chicago, IL (United States); Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Grassellino, Anna [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Martinello, Martina [Illinois Inst. of Technology, Chicago, IL (United States); Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Posen, Sam [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Romanenko, Alexander [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Zasadzinski, John [Illinois Inst. of Technology, Chicago, IL (United States)


    The present study is addressed to the theoretical description of the ultimate gradient limitation in SRF cavities. Our intent is to exploit experimental data to confirm models which provide feed-backs on how to improve the current state-of-art. New theoretical insight on the cavities limiting factor can be suitable to improve the quench field of N-doped cavities, and therefore to take advantage of high Q0 at high gradients.

  13. Ultimate capacity of piles penetrating in weak soil layers

    Directory of Open Access Journals (Sweden)

    Al-Obaidi Ahmed


    Full Text Available A pile foundation is one of the most popular forms of deep foundations. They are routinely employed to transfer axial structure loads through the soft soil to stronger bearing strata. Piles generally used to increase the load carrying capacity of the foundation and reduce the settlement of the foundation. On the other hand, many cases in practice where piles pass through different layers of soil that contain weak layers located at different depths and extension, also some time cavities with a different shape, size, and depth are found. In this study, a total of 96 cases is considered and simulated in PLAXIS 2D program aiming to understand the influence of weak soil on the ultimate pile capacity. The piles embedded in the dense sand with a layer of weak soil at different extension and location. The cross section of the geometry used in this study was designed as an axisymmetric model with the 15-node element; the boundary condition recommended at least 5D in the horizontal direction, and (L+5D in the vertical direction where D and L are the diameter and length of pile, respectively. The soil is modeled as Mohr-Coulomb, with five input parameters and the behavior of pile material represented by the linear elastic model. The results of the above cases are compared with the results found in a pile embedded in dense soil without weak layers or cavities. The results indicated that the existence of weak soil layer within the surrounding soil around the pile decreases the ultimate capacity. Furthermore, it has been found that increase in the weak soil width (extension leads to reduction in the ultimate capacity of the pile. This phenomenon is applicable to all depth of weak soil. The influence of weak layer extension on the ultimate capacity is less when it is presentin the upper soil layers.

  14. Ultimate survival in anomalous ψ(2S) decays

    International Nuclear Information System (INIS)

    Gérard, Jean-Marc; Martini, Antony


    The hierarchy among the radiative γ(π 0 ,η,η ′ ) decay channels for the ψ ′ looks quite different from the J/ψ one. The fate of charm, namely an ultimate survival of on-shell cc ¯ intermediate states, might give us the clue for this new puzzle in exclusive charmonium decays. A similar self-preservation has already been invoked in the past to solve the so-called ρπ puzzle.

  15. Hydrogeological problems in the ultimate storage of radioactive wastes

    International Nuclear Information System (INIS)

    Uerpmann, E.P.


    The following work shows how one can achieve the safe closure of ultimate-stored radioactive wastes by connecting a series of various barriers to the biosphere. The propagation of radionuclides by ground water is considered to be the most important long-term transport mechanism. Salt occurences in the Federal Republic of Germany are considered to be the best form suitable for end storage formations for known reasons. When not observing mining and hydrogeological knowledge, the danger of uncontrollable water flow in the end storage can arise from the water solubility of the salt rocks. Therefore the filling of salt mines and the subsequent procedures are dealt with in detail. The leading of radioactive nuclides is influenced by the properties of the ultimately stored wastes and by the quality of the remaining filling of the caves. These problems are dealt with in detail. A series of barriers to the closure of the underground caves are suggested and discussed. The most important barriers consist of the stability of the corresponding selected end storage structure. Possible arrangements of the storage cave are given which even after storage must maintain a high stability. Proposals are made on how the ultimately stored wastes can protect themselves against contact with free water or salt solutions. (orig.) [de

  16. Ultimate concerns in late modernity: Archer, Bourdieu and reflexivity. (United States)

    Farrugia, David; Woodman, Dan


    Through a critique of Margaret Archer's theory of reflexivity, this paper explores the theoretical contribution of a Bourdieusian sociology of the subject for understanding social change. Archer's theory of reflexivity holds that conscious 'internal conversations' are the motor of society, central both to human subjectivity and to the 'reflexive imperative' of late modernity. This is established through critiques of Bourdieu, who is held to erase creativity and meaningful personal investments from subjectivity, and late modernity is depicted as a time when a 'situational logic of opportunity' renders embodied dispositions and the reproduction of symbolic advantages obsolete. Maintaining Archer's focus on 'ultimate concerns' in a context of social change, this paper argues that her theory of reflexivity is established through a narrow misreading and rejection of Bourdieu's work, which ultimately creates problems for her own approach. Archer's rejection of any pre-reflexive dimensions to subjectivity and social action leaves her unable to sociologically explain the genesis of 'ultimate concerns', and creates an empirically dubious narrative of the consequences of social change. Through a focus on Archer's concept of 'fractured reflexivity', the paper explores the theoretical necessity of habitus and illusio for understanding the social changes that Archer is grappling with. In late modernity, reflexivity is valorized just as the conditions for its successful operation are increasingly foreclosed, creating 'fractured reflexivity' emblematic of the complex contemporary interaction between habitus, illusio, and accelerating social change. © London School of Economics and Political Science 2015.

  17. Practical goal programming

    CERN Document Server

    Jones, Dylan


    This book and its treatment of goal programming will help organizations meet targets and objectives. The book includes many worked-out examples and tutorial exercises, and is designed to demostrate and teach its readers good modeling practice.

  18. Citizen Goals Online

    Directory of Open Access Journals (Sweden)

    Catalin Vrabie


    Full Text Available The purpose of this paper is to give to public institution Web designers a better understanding of the citizens’ objectives when accessing a Web page. Understanding citizen online goals is critical because it gets to the heart of what the public institution website should or could “do.” Approach: The challenge for e-marketers is that for most agencies/institutions, there are likely to be multiple goals that represent the “reason why” citizens could come to the website. For example, a national theatre website might be very effective for people who have already been there, they know effectively what place is the best, who are the actors, etc. Research limitations: The nature of a public institution activity almost dictates the different types of goals that consumers have when visiting the site. It is clear that a citizen has a different goal when accessing a theatre Web page or when he’s accessing a municipality Web page. This is the biggest impediment for drawing a good conceptual model for a public institution Web page. Practical implications: there are likely to be many other goals that could lead people to visit the site, like receiving customer service or leaving a remark. Value: Since citizen online goals represent the starting point for Web design efforts (for public institutions, this article has attempted to highlight the nature and types of goals that e-marketers might consider when planning what their website should do in order to create. Findings: The goal a site visitor has when arriving at a website tends to be very action oriented. If the visitor has never visited the site before, the goal may simply be to evaluate the website and figure out what the site is and if it will help him. On the other hand, if the visitor has reached the site as the result of a directed search or is a repeat visitor, the user goal is likely to be specific and functional. If important citizen goals are not supported by the website, the public

  19. Citizen Goals Online

    Directory of Open Access Journals (Sweden)

    Catalin Vrabie


    Full Text Available The purpose of this paper is to give to public institution Web designers a better understanding of the citizens’ objectives when accessing a Web page. Understanding citizen online goals is critical because it gets to the heart of what the public institution website should or could “do.”Approach: The challenge for e-marketers is that for most agencies/institutions, there are likely to be multiple goals that represent the “reason why” citizens could come to the website. For example, a national theatre website might be very effective for people who have already been there, they know effectively what place is the best, who are the actors, etc.Research limitations: The nature of a public institution activity almost dictates the different types of goals that consumers have when visiting the site. It is clear that a citizen has a different goal when accessing a theatre Web page or when he’s accessing a municipality Web page. This is the biggest impediment for drawing a good conceptual model for a public institution Web page.Practical implications: there are likely to be many other goals that could lead people to visit the site, like receiving customer service or leaving a remark.Value: Since citizen online goals represent the starting point for Web design efforts (for public institutions, this article has attempted to highlight the nature and types of goals that e-marketers might consider when planning what their website should do in order to create.Findings: The goal a site visitor has when arriving at a website tends to be very action oriented. If the visitor has never visited the site before, the goal may simply be to evaluate the website and figure out what the site is and if it will help him. On the other hand, if the visitor has reached the site as the result of a directed search or is a repeat visitor, the user goal is likely to be specific and functional. If important citizen goals are not supported by the website, the public

  20. Therapeutic and prevention strategies against human enterovirus 71 infection (United States)

    Kok, Chee Choy


    Human enterovirus 71 (HEV71) is the cause of hand, foot and mouth disease and associated neurological complications in children under five years of age. There has been an increase in HEV71 epidemic activity throughout the Asia-Pacific region in the past decade, and it is predicted to replace poliovirus as the extant neurotropic enterovirus of highest global public health significance. To date there is no effective antiviral treatment and no vaccine is available to prevent HEV71 infection. The increase in prevalence, virulence and geographic spread of HEV71 infection over the past decade provides increasing incentive for the development of new therapeutic and prevention strategies against this emerging viral infection. The current review focuses on the potential, advantages and disadvantages of these strategies. Since the explosion of outbreaks leading to large epidemics in China, research in natural therapeutic products has identified several groups of compounds with anti-HEV71 activities. Concurrently, the search for effective synthetic antivirals has produced promising results. Other therapeutic strategies including immunotherapy and the use of oligonucleotides have also been explored. A sound prevention strategy is crucial in order to control the spread of HEV71. To this end the ultimate goal is the rapid development, regulatory approval and widespread implementation of a safe and effective vaccine. The various forms of HEV71 vaccine designs are highlighted in this review. Given the rapid progress of research in this area, eradication of the virus is likely to be achieved. PMID:25964873

  1. Therapeutic Inertia and Treatment Intensification. (United States)

    Josiah Willock, Robina; Miller, Joseph B; Mohyi, Michelle; Abuzaanona, Ahmed; Muminovic, Meri; Levy, Phillip D


    This review aims to emphasize how therapeutic inertia, the failure of clinicians to intensify treatment when blood pressure rises or remains above therapeutic goals, contributes to suboptimal blood pressure control in hypertensive populations. Studies reveal that the therapeutic inertia is quite common and contributes to suboptimal blood pressure control. Quality improvement programs and standardized approaches to support antihypertensive treatment intensification are ways to combat therapeutic inertia. Furthermore, programs that utilize non-physician medical professionals such as pharmacists and nurses demonstrate promise in mitigating the effects of this important problem. Therapeutic inertia impedes antihypertensive management and requires a broad effort to reduce its effects. There is an ongoing need for renewed focus and research in this area to improve hypertension control.

  2. Epigenetic Pathways of Oncogenic Viruses: Therapeutic Promises. (United States)

    El-Araby, Amr M; Fouad, Abdelrahman A; Hanbal, Amr M; Abdelwahab, Sara M; Qassem, Omar M; El-Araby, Moustafa E


    Cancerous transformation comprises different events that are both genetic and epigenetic. The ultimate goal for such events is to maintain cell survival and proliferation. This transformation occurs as a consequence of different features such as environmental and genetic factors, as well as some types of infection. Many viral infections are considered to be causative agents of a number of different malignancies. To convert normal cells into cancerous cells, oncogenic viruses must function at the epigenetic level to communicate with their host cells. Oncogenic viruses encode certain epigenetic factors that lead to the immortality and proliferation of infected cells. The epigenetic effectors produced by oncogenic viruses constitute appealing targets to prevent and treat malignant diseases caused by these viruses. In this review, we highlight the importance of epigenetic reprogramming for virus-induced oncogenesis, with special emphasis on viral epigenetic oncoproteins as therapeutic targets. The discovery of molecular components that target epigenetic pathways, especially viral factors, is also discussed. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  3. Rapid population growth and environmental degradation: ultimate versus proximate factors. (United States)

    Shaw, R P


    This philosophical review of 2 arguments about responsibility for and solutions to environmental degradation concludes that both sides are correct: the ultimate and the proximal causes. Ultimate causes of pollution are defined as the technology responsible for a given type of pollution, such as burning fossil fuel; proximate causes are defined as situation-specific factors confounding the problem, such as population density or rate of growth. Commoner and others argue that developed countries with low or negative population growth rates are responsible for 80% of world pollution, primarily in polluting technologies such as automobiles, power generation, plastics, pesticides, toxic wastes, garbage, warfaring, and nuclear weapons wastes. Distortionary policies also contribute; examples are agricultural trade protection, land mismanagement, urban bias in expenditures, and institutional rigidity., Poor nations are responsible for very little pollution because poverty allows little waste or expenditures for polluting, synthetic technologies. The proximal causes of pollution include numbers and rate of growth of populations responsible for the pollution. Since change in the ultimate cause of pollution remains out of reach, altering the numbers of polluters can make a difference. Predictions are made for proportions of the world's total waste production, assuming current 1.6 tons/capita for developed countries and 0.17 tons/capita for developing countries. If developing countries grow at current rates and become more wealthy, they will be emitting half the world's waste by 2025. ON the other hand, unsustainable population growth goes along with inadequate investment in human capital: education, health, employment, infrastructure. The solution is to improve farming technologies in the 117 non-self-sufficient countries, fund development in the most unsustainable enclaves of growing countries, break institutionalized socio-political rigidity in these enclaves, and focus on

  4. Adobe Photoshop CS5 for Photographers The Ultimate Workshop

    CERN Document Server

    Evening, Martin


    If you already have a good knowledge of Adobe Photoshop and are looking to advance your skills, Adobe Photoshop CS5 for Photographers: The Ultimate Workshop is the book you've been waiting for.  Renowned photographers Martin Evening and Jeff Schewe impart their Photoshop tips and workflow, showing you how to use a vast array of rarely seen advanced Photoshop techniques.  Whether the subject is serious retouching work, weird and wonderful compositions, or planning a shoot before you've even picked up a camera, you can be sure that the advice is based on years of practical experience.

  5. Ultimate survival in anomalous ψ(2S) decays

    Energy Technology Data Exchange (ETDEWEB)

    Gérard, Jean-Marc; Martini, Antony


    The hierarchy among the radiative γ(π{sup 0},η,η{sup ′}) decay channels for the ψ{sup ′} looks quite different from the J/ψ one. The fate of charm, namely an ultimate survival of on-shell cc{sup ¯} intermediate states, might give us the clue for this new puzzle in exclusive charmonium decays. A similar self-preservation has already been invoked in the past to solve the so-called ρπ puzzle.

  6. Determination of Ultimate Torque for Multiply Connected Cross Section Rod

    Directory of Open Access Journals (Sweden)

    V. L. Danilov


    Full Text Available The aim of this work is to determine load-carrying capability of the multiply cross-section rod. This calculation is based on the model of the ideal plasticity of the material, so that the desired ultimate torque is a torque at which the entire cross section goes into a plastic state.The article discusses the cylindrical multiply cross-section rod. To satisfy the equilibrium equation and the condition of plasticity simultaneously, two stress function Ф and φ are introduced. By mathematical transformations it has been proved that Ф is constant along the path, and a formula to find its values on the contours has been obtained. The paper also presents the rationale of the line of stress discontinuity and obtained relationships, which allow us to derive the equations break lines for simple interaction of neighboring circuits, such as two lines, straight lines and circles, circles and a different sign of the curvature.After substitution into the boundary condition at the end of the stress function Ф and mathematical transformations a formula is obtained to determine the ultimate torque for the multiply cross-section rod.Using the doubly connected cross-section and three-connected cross-section rods as an example the application of the formula of ultimate torque is studied.For doubly connected cross-section rod, the paper offers a formula of the torque versus the radius of the rod, the aperture radius and the distance between their centers. It also clearly demonstrates the torque dependence both on the ratio of the radii and on the displacement of hole. It is shown that the value of the torque is more influenced by the displacement of hole, rather than by the ratio of the radii.For the three-connected cross-section rod the paper shows the integration feature that consists in selection of a coordinate system. As an example, the ultimate torque is found by two methods: analytical one and 3D modeling. The method of 3D modeling is based on the Nadai

  7. Control to goal of cardiometabolic risk factors among Nigerians ...

    African Journals Online (AJOL)


    Jul 12, 2011 ... Therapeutic goals used to define risk or poor control were values adopted by expert groups such as ... medical wards in urban healthcare centers showed that .... *Status of control was based on the mean observed value.

  8. 75 FR 60133 - Agency Information Collection Activities: Declaration of Ultimate Consignee That Articles Were... (United States)


    ... Activities: Declaration of Ultimate Consignee That Articles Were Exported for Temporary Scientific or... the Declaration of Ultimate Consignee That Articles Were Exported for Temporary Scientific or...: Title: Declaration of Ultimate Consignee That Articles Were Exported for Temporary Scientific or...

  9. The prospects of transition metal dichalcogenides for ultimately scaled CMOS (United States)

    Thiele, S.; Kinberger, W.; Granzner, R.; Fiori, G.; Schwierz, F.


    MOSFET gate length scaling has been a main source of progress in digital electronics for decades. Today, researchers still spend considerable efforts on reducing the gate length and on developing ultimately scaled MOSFETs, thereby exploring both new device architectures and alternative channel materials beyond Silicon such as two-dimensional TMDs (transition metal dichalcogenide). On the other hand, the envisaged scaling scenario for the next 15 years has undergone a significant change recently. While the 2013 ITRS edition required a continuation of aggressive gate length scaling for at least another 15 years, the 2015 edition of the ITRS suggests a deceleration and eventually a levelling off of gate length scaling and puts more emphasis on alternative options such as pitch scaling to keep Moore's Law alive. In the present paper, future CMOS scaling is discussed in the light of emerging two-dimensional MOSFET channel, in particular two-dimensional TMDs. To this end, the scaling scenarios of the 2013 and 2015 ITRS editions are considered and the scaling potential of TMD MOSFETs is investigated by means of quantum-mechanical device simulations. It is shown that for ultimately scaled MOSFETs as required in the 2013 ITRS, the heavy carrier effective masses of the Mo- and W-based TMDs are beneficial for the suppression of direct source-drain tunneling, while to meet the significantly relaxed scaling targets of the 2016 ITRS heavy-effective-mass channels are not needed.

  10. The ultimate security bounds of quantum key distribution protocols

    International Nuclear Information System (INIS)

    Nikolopoulos, G.M.; Alber, G.


    Full text: Quantum key distribution (QKD) protocols exploit quantum correlations in order to establish a secure key between two legitimate users. Recent work on QKD has revealed a remarkable link between quantum and secret correlations. In this talk we report on recent results concerning the ultimate upper security bounds of various QKD schemes (i.e., the maximal disturbance up to which the two legitimate users share quantum correlations) under the assumption of general coherent attacks. In particular, we derive an analytic expression for the ultimate upper security bound of QKD schemes that use two mutually unbiased bases. As long as the two legitimate users focus on the sifted key and treat each pair of data independently during the post processing, our results are valid for arbitrary dimensions of the information carriers. The bound we have derived is well below the predictions of optimal cloning machines. The possibility of extraction of a secret key beyond entanglement distillation is also discussed. In the case of qutrits we argue that any eavesdropping strategy is equivalent to a symmetric one. For higher dimensions, however, such equivalence is generally no longer valid. (author)

  11. Ultimate internal pressure capacity assessment of SC structure

    International Nuclear Information System (INIS)

    Park, Hyungkui; Choi, Inkil


    An SC structure applied to a containment building can be quite effective. However, an SC structure cannot be applied to a containment building, because its internal pressure resistance performance has not been verified. The containment building, which undergoes ultimate internal pressure, resists the internal pressure through a pre-stress tendon. It is hard to apply a tendon to an SC structure because of its structural characteristics. Therefore, the internal pressure resistance performance of the SC structure itself should be ensured to apply it to a structure with internal pressure resistance. In this study, the suitability of an SC structure as a substitution for the tendon of a pressure resistant structure was evaluated. A containment structure model was used in this study, because it was representative structures that resistance of ultimate internal pressure be required. In this study, a nonlinear analysis was performed to evaluate and compare the behaviors of tendon model and SC structure model. By comparing the internal pressure-displacement according to the structure type, the stability of SC structure model was assessed

  12. Therapeutic approaches to genetic disorders

    African Journals Online (AJOL)


    Although prevention is the ideal goal for genetic disorders, various types of therapeutic ... The patient being ... pirical or aimed at controlling or mediating signs and symptoms without care. ... plications and gene therapy approaches .... genes family, have opened a wide and .... cancer where nanoparticles are used to.

  13. Therapeutic ultrasound

    International Nuclear Information System (INIS)

    Crum, Lawrence A


    The use of ultrasound in medicine is now quite commonplace, especially with the recent introduction of small, portable and relatively inexpensive, hand-held diagnostic imaging devices. Moreover, ultrasound has expanded beyond the imaging realm, with methods and applications extending to novel therapeutic and surgical uses. These applications broadly include: tissue ablation, acoustocautery, lipoplasty, site-specific and ultrasound mediated drug activity, extracorporeal lithotripsy, and the enhancement of natural physiological functions such as wound healing and tissue regeneration. A particularly attractive aspect of this technology is that diagnostic and therapeutic systems can be combined to produce totally non-invasive, imageguided therapy. This general lecture will review a number of these exciting new applications of ultrasound and address some of the basic scientific questions and future challenges in developing these methods and technologies for general use in our society. We shall particularly emphasize the use of High Intensity Focused Ultrasound (HIFU) in the treatment of benign and malignant tumors as well as the introduction of acoustic hemostasis, especially in organs which are difficult to treat using conventional medical and surgical techniques. (amum lecture)

  14. Perception of future goals

    DEFF Research Database (Denmark)

    Ottsen, Christina L.; Berntsen, Dorthe

    The current study: a cross-cultural comparison between the Middle East and Scandinavia. Two societies that offer a unique opportunity to examine gender and cultural differences in perception of personal goals. Previous studies show that imagined future events are affected by memories of personal...

  15. Materialistic Values and Goals. (United States)

    Kasser, Tim


    Materialism comprises a set of values and goals focused on wealth, possessions, image, and status. These aims are a fundamental aspect of the human value/goal system, standing in relative conflict with aims concerning the well-being of others, as well as one's own personal and spiritual growth. Substantial evidence shows that people who place a relatively high priority on materialistic values/goals consume more products and incur more debt, have lower-quality interpersonal relationships, act in more ecologically destructive ways, have adverse work and educational motivation, and report lower personal and physical well-being. Experimentally activating materialistic aims causes similar outcomes. Given these ills, researchers have investigated means of decreasing people's materialism. Successful interventions encourage intrinsic/self-transcendent values/goals, increase felt personal security, and/or block materialistic messages from the environment. These interventions would likely be more effective if policies were also adopted that diminished contemporary culture's focus on consumption, profit, and economic growth.

  16. An analysis of budgetary goals impacting organizational performance

    Directory of Open Access Journals (Sweden)

    Cheok MUI YEE


    Full Text Available This study proposes a conceptual review of how budgetary goals impact organizational performance. The aim of this study is to get a better understanding of the direct and indirect relationship between the organization’s decision-making process and operational performances. Setting the budget particularly influences subordinates’ budget goal levels and motivations (i.e., budget goal acceptance and budget goal commitment, which ultimately enhances the organization’s performance. To test these relationships, data were collected using the three perspectives approach: budgetary goal, budgetary participation and budgetary evaluation. The study provided evidence that perception of fairness mediates the relation between the levels of budget participation and goal commitment, whereas goal commitment mediates the relation between fairness perceptions and performance. At the end of the article, there are some implications for SMEs industries and some suggestions for future studies.

  17. Ultimate Electrical Means for Severe Accident and Multi Unit Event Management

    International Nuclear Information System (INIS)

    Guisez, Xavier


    Following the Multi Unit Severe Accident that occurred at Fukushima as a result of the tsunami on 11 March 2011, the European Council decided to submit its Nuclear Power Plants to a Stress Test. In Belgium, this Stress Test, named BEST (Belgian Stress Test), was successfully concluded at the end of 2011. Nevertheless, Electrabel decided, in agreement with the Authorities, to start a beyond design basis action plan, with the goal to mitigate the consequences of a Beyond Design Basis Accident and a Multi Unit Event. Consequently, this has led to an improvement of the robustness of its Nuclear Power Plants. Considering the importance of electrical power supply to a nuclear power plant, a significant part of this action plan consisted of setting up a mobile, 'plug and play' method for the electrical power supply to some major safety systems. In order to install this ultimate power supply, three factors were retained as essential. First, important reactor monitoring instrumentation is preserved. Second, core cooling is provided at all times. Finally, systems are easily made operational within a very short delay of time. During normal operation and Design Basis Events, core cooling is provided by High Voltage equipment. However, during high stress circumstances, it is too complex to realize connections on this equipment. Therefore, analysis was performed to realize core cooling with, easier to handle, Low Voltage equipment. These systems are powered by several GenSets, especially designed and manufactured for this application. The outcome of this project are easy to use, ultimate means, that supply electric power to important safety systems in order to drastically reduce the risk of core damage, during a beyond design basis event. Additionally, for all ultimate means, procedures and training modules were developed for the operators. (authors)

  18. On the ultimate uncertainty of the top quark pole mass

    Energy Technology Data Exchange (ETDEWEB)

    Beneke, M. [Technische Univ. Muenchen, Garching (Germany). Physik-Department; Marquard, P. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Nason, P. [INFN, Sezione di Milano Bicocca (Italy); Steinhauser, M. [Karlsruher Institut fuer Technologie (Germany). Inst. fuer Theoretische Teilchenphysik


    We combine the known asymptotic behaviour of the QCD perturbation series expansion, which relates the pole mass of a heavy quark to the MS mass, with the exact series coefficients up to the four-loop order to determine the ultimate uncertainty of the top-quark pole mass due to the renormalon divergence. We perform extensive tests of our procedure by varying the number of colours and flavours, as well as the scale of the strong coupling and the MS mass, and conclude that this uncertainty is around 70 MeV. We further estimate the additional contribution to the mass relation from the five-loop correction and beyond to be 250 MeV.

  19. On the ultimate uncertainty of the top quark pole mass

    International Nuclear Information System (INIS)

    Beneke, M.; Nason, P.; Steinhauser, M.


    We combine the known asymptotic behaviour of the QCD perturbation series expansion, which relates the pole mass of a heavy quark to the MS mass, with the exact series coefficients up to the four-loop order to determine the ultimate uncertainty of the top-quark pole mass due to the renormalon divergence. We perform extensive tests of our procedure by varying the number of colours and flavours, as well as the scale of the strong coupling and the MS mass, and conclude that this uncertainty is around 70 MeV. We further estimate the additional contribution to the mass relation from the five-loop correction and beyond to be 250 MeV.

  20. On the ultimate uncertainty of the top quark pole mass (United States)

    Beneke, M.; Marquard, P.; Nason, P.; Steinhauser, M.


    We combine the known asymptotic behaviour of the QCD perturbation series expansion, which relates the pole mass of a heavy quark to the MS ‾ mass, with the exact series coefficients up to the four-loop order to determine the ultimate uncertainty of the top-quark pole mass due to the renormalon divergence. We perform extensive tests of our procedure by varying the number of colours and flavours, as well as the scale of the strong coupling and the MS ‾ mass. Including an estimate of the internal bottom and charm quark mass effect, we conclude that this uncertainty is around 110 MeV. We further estimate the additional contribution to the mass relation from the five-loop correction and beyond to be around 300 MeV.

  1. Multiple (Two) Met Bel 601 In Series Ultimate Vacuum Testing

    Energy Technology Data Exchange (ETDEWEB)

    Restivo, M. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)


    SRNL Environmental and Chemical Process Technology (E&CPT) was requested to perform testing of vacuum pumps per a verbal request from the Customer, SRNL Hydrogen Processing Technology. Tritium Operations is currently having difficulties procuring the Normetex™® Model 15 m3/hr (9 CFM) vacuum pump (formerly Normetex Pompes, now EumecaSARL). One possible solution proposed by Hydrogen Processing Technology personnel is to use two Senior Aerospace Metal Bellows MB-601 vacuum pumps piped with the heads in series, and the pumps in series (Figure 1 below). This memorandum documents the ultimate vacuum testing that was performed to determine if this concept was a viable alternate vacuum pump strategy. This testing dovetails with previous pump evaluations documented in references 1 and 2.

  2. Patient-relevant treatment goals in psoriasis. (United States)

    Blome, Christine; Gosau, Ramona; Radtke, Marc A; Reich, Kristian; Rustenbach, Stephan J; Spehr, Christina; Thaçi, Diamant; Augustin, Matthias


    Patient-oriented care requires therapeutic decisions to agree with the patients' treatment needs and goals. This study addressed the following questions: What is important to psoriasis patients starting systemic treatment? How stable are these preferences within the first year of treatment? Are treatment goals associated with age, gender, or treatment success? The importance of treatment goals was assessed for patients with moderate-to-severe psoriasis in the German Psoriasis Registry (PsoBest) at baseline (onset of a systemic treatment; n = 3066) and at a 1-year follow-up (n = 1444) using the Patient Benefit Index (PBI). Treatment success was measured with PBI global score and Psoriasis Area Severity Index (PASI). Patients with moderate-to-severe psoriasis pursued a wide range of different goals. The most general treatment goals were rated most relevant, including skin healing and quick skin improvement (94.8/94.5 % "quite" or "very" important), confidence in the therapy (93.0 %), control over the disease (92.3 %), and a clear diagnosis and therapy (89.6 %). Further important goals related to not being in fear of the disease getting worse (84.8 %), reduction in itching (83.9 %), burning (70.6 %), and pain (60.6 %) as well as attaining a normal everyday life (78.4 %) and low treatment burden (64.2-77.9 %). Goals were mostly not associated with sex and gender. Goal importance slightly increased with treatment success. In a substantial proportion of patients (30.3-54.7 %) goal importance changed within 1 year after onset of systemic treatment. We conclude that treatment goal importance should be assessed in clinical practice on a regular basis.

  3. Ultimate Drivers and Proximate Correlates of Polyandry in Predatory Mites.

    Directory of Open Access Journals (Sweden)

    Peter Schausberger

    Full Text Available Polyandry is more widespread than anticipated from Bateman's principle but its ultimate (evolutionary causes and proximate (mechanistic correlates are more difficult to pinpoint than those of polygyny. Here, we combined mating experiments, quantification of reproductive traits and microsatellite genotyping to determine the fitness implications of polyandry in two predatory mite species, where males are highly polygynous (up to 45 fertilized females during life, whereas females range from monandry to various polyandry levels. The medium-level polyandrous (up to eight male mates possible Neoseiulus californicus received clear direct and indirect benefits: multiply mated females produced more offspring with higher survival chances over longer times than singly mated females. In contrast, singly and multiply mated females of the low-level polyandrous (commonly two male mates at maximum Phytoseiulus persimilis produced similar numbers of offspring having similar survival chances. In both species, multiple mating resulted in mixed offspring paternities, opening the chance for indirect fitness benefits such as enhanced genetic compatibility, complementarity and/or variability. However, the female re-mating likelihood and the paternity chance of non-first male mates were lower in P. persimilis than in N. californicus. Regarding proximate factors, in both species first mating duration and female re-mating likelihood were negatively correlated. Based on occasional fertilization failure of first male mates in P. persimilis, and mixed offspring paternities in both species, we argue that fertilization assurance and the chance to gain indirect fitness benefits are the ultimate drivers of polyandry in P. persimilis, whereas those of N. californicus are higher offspring numbers coupled with enhanced offspring viability and possibly other indirect fitness benefits. Overall, the adaptive significance and proximate events well reflected the polyandry levels. Our

  4. Ultimate Drivers and Proximate Correlates of Polyandry in Predatory Mites. (United States)

    Schausberger, Peter; Patiño-Ruiz, J David; Osakabe, Masahiro; Murata, Yasumasa; Sugimoto, Naoya; Uesugi, Ryuji; Walzer, Andreas


    Polyandry is more widespread than anticipated from Bateman's principle but its ultimate (evolutionary) causes and proximate (mechanistic) correlates are more difficult to pinpoint than those of polygyny. Here, we combined mating experiments, quantification of reproductive traits and microsatellite genotyping to determine the fitness implications of polyandry in two predatory mite species, where males are highly polygynous (up to 45 fertilized females during life), whereas females range from monandry to various polyandry levels. The medium-level polyandrous (up to eight male mates possible) Neoseiulus californicus received clear direct and indirect benefits: multiply mated females produced more offspring with higher survival chances over longer times than singly mated females. In contrast, singly and multiply mated females of the low-level polyandrous (commonly two male mates at maximum) Phytoseiulus persimilis produced similar numbers of offspring having similar survival chances. In both species, multiple mating resulted in mixed offspring paternities, opening the chance for indirect fitness benefits such as enhanced genetic compatibility, complementarity and/or variability. However, the female re-mating likelihood and the paternity chance of non-first male mates were lower in P. persimilis than in N. californicus. Regarding proximate factors, in both species first mating duration and female re-mating likelihood were negatively correlated. Based on occasional fertilization failure of first male mates in P. persimilis, and mixed offspring paternities in both species, we argue that fertilization assurance and the chance to gain indirect fitness benefits are the ultimate drivers of polyandry in P. persimilis, whereas those of N. californicus are higher offspring numbers coupled with enhanced offspring viability and possibly other indirect fitness benefits. Overall, the adaptive significance and proximate events well reflected the polyandry levels. Our study provides a

  5. Selfish goals serve more fundamental social and biological goals. (United States)

    Becker, D Vaughn; Kenrick, Douglas T


    Proximate selfish goals reflect the machinations of more fundamental goals such as self-protection and reproduction. Evolutionary life history theory allows us to make predictions about which goals are prioritized over others, which stimuli release which goals, and how the stages of cognitive processing are selectively influenced to better achieve the aims of those goals.

  6. SoundScapes - Beyond Interaction... in search of the ultimate human-centred interface

    DEFF Research Database (Denmark)

    Brooks, Tony


    that can also benefit communication. To achieve this a new generation of intuitive natural interfaces will be required and SoundScapes (see below) is a step toward this goal to discover the ultimate interface for matching the human experience to technology. Emergent hypothesis that have developed...... as a result of the SoundScapes research will be discussed. Introduction to SoundScapes SoundScapes is a contemporary art concept that has become widely known as an interdisciplinary platform for knowledge exchange, innovative product creation of creative and scientific work that uses non-invasive sensor...... Resonance. The multimedia content is adaptable so that the environment is tailored for each participant according to a user profile. This full body movement or the smallest of gesture results in human data input to SoundScapes. The same technology that enables this empowerment is used for performance art...

  7. TARGET Research Goals (United States)

    TARGET researchers use various sequencing and array-based methods to examine the genomes, transcriptomes, and for some diseases epigenomes of select childhood cancers. This “multi-omic” approach generates a comprehensive profile of molecular alterations for each cancer type. Alterations are changes in DNA or RNA, such as rearrangements in chromosome structure or variations in gene expression, respectively. Through computational analyses and assays to validate biological function, TARGET researchers predict which alterations disrupt the function of a gene or pathway and promote cancer growth, progression, and/or survival. Researchers identify candidate therapeutic targets and/or prognostic markers from the cancer-associated alterations.

  8. Translational research in addiction: toward a framework for the development of novel therapeutics. (United States)

    Paterson, Neil E


    The development of novel substance use disorder (SUD) therapeutics is insufficient to meet the medical needs of a growing SUD patient population. The identification of translatable SUD models and tests is a crucial step in establishing a framework for SUD therapeutic development programs. The present review begins by identifying the clinical features of SUDs and highlights the narrow regulatory end-point required for approval of a novel SUD therapeutic. A conceptual overview of dependence is provided, followed by identification of potential intervention targets in the addiction cycle. The main components of the addiction cycle provide the framework for a discussion of preclinical models and their clinical analogs, all of which are focused on isolated behavioral end-points thought to be relevant to the persistence of compulsive drug use. Thus, the greatest obstacle to successful development is the gap between the multiplicity of preclinical and early clinical end-points and the regulatory end-point of sustained abstinence. This review proposes two pathways to bridging this gap: further development and validation of the preclinical extended access self-administration model; inclusion of secondary end-points comprising all of the measures highlighted in the present discussion in Phase 3 trials. Further, completion of the postdictive validation of analogous preclinical and clinical assays is of high priority. Ultimately, demonstration of the relevance and validity of a variety of end-points to the ultimate goal of abstinence will allow researchers to identify truly relevant therapeutic mechanisms and intervention targets, and establish a framework for SUD therapeutic development that allows optimal decision-making and resource allocation. 2011 Elsevier Inc. All rights reserved.

  9. Efficiency Of Different Teaching Models In Teaching Of Frisbee Ultimate

    Directory of Open Access Journals (Sweden)

    Žuffová Zuzana


    Full Text Available The aim of the study was to verify the efficiency of two frisbee ultimate teaching models at 8-year grammar schools relative to age. In the experimental group was used a game based model (Teaching Games for Understanding and in the control group the traditional model based on teaching techniques. 6 groups of female students took part in experiment: experimental group 1 (n=10, age=11.6, experimental group 2 (n=12, age=13.8, experimental group 3 (n=14, age =15.8, control group 1 (n=11, age =11.7, control group 2 (n=10, age =13.8 and control group 3 (n=9, age =15.8. Efficiency of the teaching models was evaluated based of game performance and special knowledge results. Game performance was evaluated by the method of game performance assessment based on GPAI (Game Performance Assessment Instrument through video record. To verify level of knowledge, we used a knowledge test, which consisted of questions related to the rules and tactics knowledge of frisbee ultimate. To perform statistical evaluation Mann-Whitney U-test was used. Game performance assessment and knowledge level indicated higher efficiency of TGfU in general, but mostly statistically insignificant. Experimental groups 1 and 2 were significantly better in the indicator that evaluates tactical aspect of game performance - decision making (p<0.05. Experimental group 3 was better in the indicator that evaluates skill execution - disc catching. The results showed that the students of the classes taught by game based model reached partially better game performance in general. Experimental groups achieved from 79.17 % to 80 % of correct answers relating to the rules and from 75 % to 87.5 % of correct answers relating to the tactical knowledge in the knowledge test. Control groups achieved from 57.69 % to 72.22 % of correct answers relating to the rules and from 51.92 % to 72.22 % of correct answers relating to the tactical knowledge in the knowledge test.

  10. Process Inherent Ultimate Safety (PIUS) reactor evaluation study: Final report

    International Nuclear Information System (INIS)


    This report presents the results of an independent study by United Engineers and Constructors (UNITED) of the SECURE-P Process Inherent Ultimate Safety (PIUS) Reactor Concept which is presently under development by the Swedish light water reactor vendor ASEA-ATOM of Vasteras, Sweden. This study was performed to investigate whether there is any realistic basis for believing that the PIUS reactor could be a viable competitor in the US energy market in the future. Assessments were limited to the technical, economic and licensing aspects of PIUS. Socio-political issues, while certainly important in answering this question, are so broad and elusive that it was considered that addressing them with the limited perspective of one small group from one company would be of questionable value and likely be misleading. Socio-political issues aside, the key issue is economics. For this reason, the specific objectives of this study were to determine if the estimated PIUS plant cost will be competitive in the US market and to identify and evaluate the technical and licensing risks that might make PIUS uneconomical or otherwise unacceptable

  11. Episodic foresight and anxiety: Proximate and ultimate perspectives. (United States)

    Miloyan, Beyon; Bulley, Adam; Suddendorf, Thomas


    In this paper, we examine the relationship between episodic foresight and anxiety from an evolutionary perspective, proposing that together they confer an advantage for modifying present moment decision-making and behaviour in the light of potential future threats to fitness. We review the body of literature on the role of episodic foresight in anxiety, from both proximate and ultimate perspectives. We propose that anxious feelings associated with episodic simulation of possible threat-related future events serve to imbue these simulations with motivational currency. Episodic and semantic details of a future threat may be insufficient for motivating its avoidance, but anxiety associated with a simulation can provoke adaptive threat management. As such, we detail how anxiety triggered by a self-generated, threat-related future simulation prepares the individual to manage that threat (in terms of its likelihood and/or consequences) over greater temporal distances than observed in other animals. We then outline how anxiety subtypes may represent specific mechanisms for predicting and managing particular classes of fitness threats. This approach offers an inroad for understanding the nature of characteristic future thinking patterns in anxiety disorders and serves to illustrate the adaptive function of the mechanism from which clinical anxiety deviates. © 2015 The British Psychological Society.

  12. Yield, utilization, storage and ultimate storage of depleted uranium

    International Nuclear Information System (INIS)

    Aumueller, L.; Hermann, J.


    More than 80% of the uranium leaving uranium enrichment plants is depleted to a residual content of about 0,25% U 235. Due to the present ineconomical further depletion to the technically possible residual content of 0,1% U 235, the so-called 'tails' are first of all stored. The quantity of stored depleted uranium in the FRG should be about 100.000 t by the year 2000. It represents a strategic reserve for future energy supply regardless of profitableness. The study analysis the conceivable possible uses for the tails quantity considered. These are, besides further depletion whose profitableness is considered, also the use as breeder material in breeder reactors and the use in the non-nuclear field. The main part of the study deals with the various storage possibilities of the depleted uranium in oxidic or fluoride form. A comparison of costs of alternative storage concepts showed a clear advantage for the storage of UF 6 in 48 inch containers already in use. The conceivable accidents in storing are analyzed and measures to reduce the consequences are discussed. Finally, the problems of ultimate storage for the remaining waste after further depletion or use are investigated and the costs arising here are also estimated. (RB) [de

  13. Optimized molten salt receivers for ultimate trough solar fields (United States)

    Riffelmann, Klaus-J.; Richert, Timo; Kuckelkorn, Thomas


    Today parabolic trough collectors are the most successful concentrating solar power (CSP) technology. For the next development step new systems with increased operation temperature and new heat transfer fluids (HTF) are currently developed. Although the first power tower projects have successfully been realized, up to now there is no evidence of an all-dominant economic or technical advantage of power tower or parabolic trough. The development of parabolic trough technology towards higher performance and significant cost reduction have led to significant improvements in competitiveness. The use of molten salt instead of synthetic oil as heat transfer fluid will bring down the levelized costs of electricity (LCOE) even further while providing dispatchable energy with high capacity factors. FLABEG has developed the Ultimate TroughTM (UT) collector, jointly with sbp Sonne GmbH and supported by public funds. Due to its validated high optical accuracy, the collector is very suitable to operate efficiently at elevated temperatures up to 550 °C. SCHOTT will drive the key-innovations by introducing the 4th generation solar receiver that addresses the most significant performance and cost improvement measures. The new receivers have been completely redesigned to provide a product platform that is ready for high temperature operation up to 550 °C. Moreover distinct product features have been introduced to reduce costs and risks in solar field assembly and installation. The increased material and design challenges incurred with the high temperature operation have been reflected in sophisticated qualification and validation procedures.

  14. Accounting conservatism,ultimate ownership and investment efficiency

    Institute of Scientific and Technical Information of China (English)

    Xiaodong Xu; Xia Wang; Nina Han


    Purpose-The purpose of this paper is to analyze and examine the role of accounting conservatism on firm investment behavior in China.Design/methodology/approach-By combining a developed theoretical framework and empirical study,this paper examines the impacts of accounting conservatism on firm investment.The sample and data are all collected from Wind and CAMAR databases.Findings-The paper finds that the association between accounting conservatism and capital expenditure is significantly positive when inside capital is not enough to use for investment,suggesting that conservatism can expend the level of investment by decreasing information asymmetry and cost of capital;however,the association between accounting conservatism and capital expenditure is significantly negative when inside capital is enough to use for investment,suggesting that conservatism can curtail the level of investment by mitigating the interest conflicts between management and outside shareholders and decreasing agency costs.Additionally,the paper finds that the severity of information asymmetry and agency problem affects the role of accounting conservatism on firm investment behaviour,and the association between accounting conservatism and capital expenditure is weaker for firms with ultimate ownership controller as local government or individuals.Originality/value-This is the first paper to analyze and examine the impacts of accounting conservatism on firm investment in China directly.The findings are also useful to explain the awkward predicament found by prior literature.

  15. Ultimate storage of radioactive wastes annual report, 1973

    International Nuclear Information System (INIS)

    The present report is a cooperative effort by the Company for Radiation and Environmental Research, Munich, and the Company for Nuclear Research, Karlsruhe, and provides a survey of work carried out during 1973 in the area of ultimate storage of radioactive wastes. Mining and construction works which were carried out in the Asse Salt Mine near Remlingen both underground as well as above the ground and which were used for repair, maintenance and expansion of the operation consistent with its future tasks are reported. The storage of low-level wastes at the 750 m level and also the test-oriented storage of medium-level waste materials at the 490 m level were carried out within the reporting period. Shielded storage casks S7V developed by the GfK were used for the first time in September for transporting 200 l iron-hooped drums filled with medium-level radioactive wastes to Asse, each shipment always containing seven drums. With two round-trips a week taking place between the Nuclear Research Center, Karlsruhe and the Asse II shaft installation, 14 drums were brought each week so that, by the end of the year, the quantity in storage amounted to a total of 233 drums. Further information is provided concerning the present status of research work in the fields of oromechanics, geology and hydrology as well as other findings. Further, storage techniques are discussed which are presently in the planning stage

  16. Thermal performance measurements on ultimate heat sinks--cooling ponds

    International Nuclear Information System (INIS)

    Hadlock, R.K.; Abbey, O.B.


    The primary objective of the studies described is to obtain the requisite data, with respect to modeling requirements, to characterize thermal performance of heat sinks for nuclear facilities existing at elevated water temperatures in result of experiencing a genuinely large heat load and responding to meteorological influence. The data should reflect thermal performance for combinations leading to worst-case meteorological influence. A geothermal water retention basin has been chosen as the site for the first measurement program and data have been obtained in the first of several experiments scheduled to be performed there. These data illustrate the thermal and water budgets during episodes of cooling from an initially high pond water bulk temperature. Monitoring proceeded while the pond experienced only meteorological and seepage influence. The data are discussed and are presented as a data volume which may be used for calculation purposes. Suggestions for future measurement programs are stated with the intent to maintain and improve relevance to nuclear ultimate heat sinks while continuing to examine the performance of the analog geothermal pond. It is further suggested that the geothermal pond, with some modification, may be a suitable site for spray pond measurements

  17. Exploring Ultimate Water Capillary Evaporation in Nanoscale Conduits. (United States)

    Li, Yinxiao; Alibakhshi, Mohammad Amin; Zhao, Yihong; Duan, Chuanhua


    Capillary evaporation in nanoscale conduits is an efficient heat/mass transfer strategy that has been widely utilized by both nature and mankind. Despite its broad impact, the ultimate transport limits of capillary evaporation in nanoscale conduits, governed by the evaporation/condensation kinetics at the liquid-vapor interface, have remained poorly understood. Here we report experimental study of the kinetic limits of water capillary evaporation in two dimensional nanochannels using a novel hybrid channel design. Our results show that the kinetic-limited evaporation fluxes break down the limits predicated by the classical Hertz-Knudsen equation by an order of magnitude, reaching values up to 37.5 mm/s with corresponding heat fluxes up to 8500 W/cm 2 . The measured evaporation flux increases with decreasing channel height and relative humidity but decreases as the channel temperature decreases. Our findings have implications for further understanding evaporation at the nanoscale and developing capillary evaporation-based technologies for both energy- and bio-related applications.

  18. Orienting Oneself for Leadership: The Role of Goal Orientation in Leader Developmental Readiness. (United States)

    Culbertson, Satoris S; Jackson, Alexander T


    The ways in which individuals approach achievement situations influence their use of self-management activities such as goal setting, feedback seeking, and developmental strategies, and ultimately impact success in leader development. © 2016 Wiley Periodicals, Inc., A Wiley Company.

  19. Ultimate compression after impact load prediction in graphite/epoxy coupons using neural network and multivariate statistical analyses (United States)

    Gregoire, Alexandre David


    The goal of this research was to accurately predict the ultimate compressive load of impact damaged graphite/epoxy coupons using a Kohonen self-organizing map (SOM) neural network and multivariate statistical regression analysis (MSRA). An optimized use of these data treatment tools allowed the generation of a simple, physically understandable equation that predicts the ultimate failure load of an impacted damaged coupon based uniquely on the acoustic emissions it emits at low proof loads. Acoustic emission (AE) data were collected using two 150 kHz resonant transducers which detected and recorded the AE activity given off during compression to failure of thirty-four impacted 24-ply bidirectional woven cloth laminate graphite/epoxy coupons. The AE quantification parameters duration, energy and amplitude for each AE hit were input to the Kohonen self-organizing map (SOM) neural network to accurately classify the material failure mechanisms present in the low proof load data. The number of failure mechanisms from the first 30% of the loading for twenty-four coupons were used to generate a linear prediction equation which yielded a worst case ultimate load prediction error of 16.17%, just outside of the +/-15% B-basis allowables, which was the goal for this research. Particular emphasis was placed upon the noise removal process which was largely responsible for the accuracy of the results.

  20. Predicting Subsequent Task Performance From Goal Motivation and Goal Failure

    Directory of Open Access Journals (Sweden)

    Laura Catherine Healy


    Full Text Available Recent research has demonstrated that the cognitive processes associated with goal pursuit can continue to interfere with unrelated tasks when a goal is unfulfilled. Drawing from the self-regulation and goal-striving literatures, the present study explored the impact of goal failure on subsequent cognitive and physical task performance. Furthermore, we examined if the autonomous or controlled motivation underpinning goal striving moderates the responses to goal failure. Athletes (75 male, 59 female, Mage = 19.90 years, SDage = 3.50 completed a cycling trial with the goal of covering a given distance in 8 minutes. Prior to the trial, their motivation was primed using a video. During the trial they were provided with manipulated performance feedback, thus creating conditions of goal success or failure. No differences emerged in the responses to goal failure between the primed motivation or performance feedback conditions. We make recommendations for future research into how individuals can deal with failure in goal striving.

  1. Motivational Goal Bracketing: An Experiment

    DEFF Research Database (Denmark)

    Koch, Alexander; Nafziger, Julia

    We study in an online, real-effort experiment how the bracketing of non-binding goals affects performance in a work-leisure self-control problem. We externally induce the goal bracket - daily goals or a weekly goal - and within that bracket let subjects set goals for how much they want to work over...... a one-week period. Our theoretical model predicts (i) that weekly goals create incentives to compensate for a lower than desired performance today with the promise to work harder tomorrow, whereas daily goals exclude such excuses; (ii) that subjects with daily goals set higher goals in aggregate...... and work harder than those with weekly goals. Our data support these predictions. Surprisingly, however, when goals are combined with an externally enforced commitment that requires subjects to spend less than a minute each day on the task to get started working, performance deteriorates because of high...

  2. Property company's sustainability goals. (United States)

    Ormsby, Kim


    In a keynote presentation on the second morning of this year's Healthcare Estates conference, Kim Ormsby (pictured), national corporate social responsibility (CSR) and sustainability manager at NHS Property Services, discussed how, as part of its broader goals of 'supporting the NHS in delivering clinical services', and 'helping to enhance the experience' of patients visiting its buildings, the organization would continue to pursue and embed in its activities sustainable policies wherever and whenever possible, encouraging both its staff and tenants to take a similar approach. In an informative address, she highlighted some of the key steps the property company had already taken to encourage a proactive approach. Echoing the sentiments of Day One keynote speaker, Julian Hartley (see pages 55-60), she argued that one of the fundamentals to success was wide-ranging staff engagement.

  3. Different way, same goal

    CERN Multimedia

    Antonella Del Rosso & Fabio Capello


    Radio-oncologists and radiotherapists represented a large proportion of the doctors and clinicians who attended the ICTR-PHE 2012 conference. With them were also biologists and doctors of nuclear medicine. They presented the state of the art of their research that touches on the genetics and biology of tumours as well as on futuristic drugs that selectively target malignant cells. The future of cancer treatment seems to lie in the personalised approach.   When the members of the life sciences community took over from the physicists, the focus remained basically the same. Just another sign of the fact that the different communities are leading the same battle and have the same goal. However, the methodologies and issues can be very different. The example of hadrontherapy illustrates the situation well: while for physicists this is a relatively well-established concept, medical doctors consider that the amount of patient data available is still very small. Several clinical trials are in progress ...

  4. DOE goals: Excellence, openness

    International Nuclear Information System (INIS)

    Isaacs, T.H.


    The author feels that the benefit of the experience and programmatic resources it has developed since passage of the Nuclear Waste Policy Act in 1982 and of the sound and flexible policy framework provided by the amendments, DOE is confident that program objectives can be met on a schedule that balances the needs for technical excellence, institutional openness, and timely acceptance. As the program evolves, DOE will continue to assess how effectively policies are serving program objectives. The need for flexibility in developing a first-of-a-kind system is essential. But flexibility does not alter the need for program stability, which, in turn, requires a commonly shared commitment to realizing the program's goals. This commitment must rest upon a pragmatic understanding of the realities of waste-management system development

  5. Seismic analysis - what goal

    International Nuclear Information System (INIS)

    Tagart, S.W.


    The seismic analysis of nuclear components is characterized today by extensive engineering computer calculations in order to satisfy both the component standard codes such as ASME III as well as federal regulations and guides. The current nuclear siesmic design procedure has envolved in a fragmented fashion and continues to change its elements as improved technology leads to changing standards and guides. The dominant trend is a monotonic increase in the overall conservation with time causing a similar trend in costs of nuclear power plants. Ironically the improvements in the state of art are feeding a process which is eroding the very incentives that attracted us to nuclear power in the first place. This paper examines the cause of this process and suggests that what is needed is a realistic goal which appropriately addresses the overall uncertainty of the seismic design process. (Auth.)

  6. BROOKHAVEN: Proton goal reached

    International Nuclear Information System (INIS)



    On March 30 the 35-year old Alternating Gradient Synchrotron (AGS) exceeded its updated design goal of 6 x 10 13 protons per pulse (ppp), by accelerating 6.3 x 10 13 ppp, a world record intensity. This goal was set 11 years ago and achieving it called for the construction of a new booster and the reconstruction of much of the AGS. The booster was completed in 1991, and reached its design intensity of 1.5 x 10 13 ppp in 1993. The AGS reconstruction was finished in 1994, and by July of that year the AGS claimed a new US record intensity for a proton synchrotron of 4 x 10 13 ppp, using four booster pulses. Reaching the design intensity was scheduled for 1995. In 1994, the AGS had seemed to be solidly limited to 4 x 10 13 ppp, but in 1995 the operations crew, working on their own in the quiet of the owl shift, steadily improved the intensity, regularly setting new records, much to the bemusement of the machine physicists. The physicists, however, did contribute. A second harmonic radiofrequency cavity in the booster increased the radiofrequency bucket area for capture, raising the booster intensity from 1.7 to 2.1 x 10 13 ppp. In the AGS, new radiofrequency power supplies raised the available voltage from 8 to 13 kV, greatly enhancing the beam loading capabilities of the system. A powerful new transverse damping system successfully controlled instabilities that otherwise would have destroyed the beam in less than a millisecond. Also in the AGS, 35th harmonic octupole resonances were found

  7. BROOKHAVEN: Proton goal reached

    Energy Technology Data Exchange (ETDEWEB)



    On March 30 the 35-year old Alternating Gradient Synchrotron (AGS) exceeded its updated design goal of 6 x 10{sup 13} protons per pulse (ppp), by accelerating 6.3 x 10{sup 13} ppp, a world record intensity. This goal was set 11 years ago and achieving it called for the construction of a new booster and the reconstruction of much of the AGS. The booster was completed in 1991, and reached its design intensity of 1.5 x 10{sup 13} ppp in 1993. The AGS reconstruction was finished in 1994, and by July of that year the AGS claimed a new US record intensity for a proton synchrotron of 4 x 10{sup 13} ppp, using four booster pulses. Reaching the design intensity was scheduled for 1995. In 1994, the AGS had seemed to be solidly limited to 4 x 10{sup 13} ppp, but in 1995 the operations crew, working on their own in the quiet of the owl shift, steadily improved the intensity, regularly setting new records, much to the bemusement of the machine physicists. The physicists, however, did contribute. A second harmonic radiofrequency cavity in the booster increased the radiofrequency bucket area for capture, raising the booster intensity from 1.7 to 2.1 x 10{sup 13} ppp. In the AGS, new radiofrequency power supplies raised the available voltage from 8 to 13 kV, greatly enhancing the beam loading capabilities of the system. A powerful new transverse damping system successfully controlled instabilities that otherwise would have destroyed the beam in less than a millisecond. Also in the AGS, 35th harmonic octupole resonances were found.

  8. R&D paths toward achieving ultimate capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Peter Kneisel


    Superconducting niobium cavities for particle accelerator application are performing nowadays better than ever and a series of procedures have been established--if applied properly--which will result in multi-cell cavity gradients of up to E{sub acc} = 35 MV/m, the design goal for the International Linear Collider (ILC). In several cases gradients above 40 MV/m have been measured in single cell tests. These gradients are close to or at the critical magnetic field value for niobium--at least what is believed to be the fundamental limitation of the material. However, there are still some open questions, whether the value for the superheated magnetic field of {approx} 180 mT is the final answer.

  9. Evolving paradigms in clinical pharmacology and therapeutics for the treatment of Duchenne muscular dystrophy. (United States)

    Huard, J; Mu, X; Lu, A


    Progressive muscle weakness and degeneration due to the lack of dystrophin eventually leads to the loss of independent ambulation by the middle of the patient's second decade, and a fatal outcome due to cardiac or respiratory failure by the third decade. More specifically, loss of sarcolemmal dystrophin and the dystrophin-associated glycoprotein (DAG) complex promotes muscle fiber damage during muscle contraction. This process results in an efflux of creatine kinase (CK), an influx of calcium ions, and the recruitment of T cells, macrophages, and mast cells to the damaged muscle, causing progressive myofiber necrosis. For the last 20 years, the major goal in the development of therapeutic approaches to alleviate muscle weakness in DMD has been centered on the restoration of dystrophin or proteins that are analogous to dystrophin, such as utrophin, through a variety of modalities including cell therapy, gene therapy, gene correction, and the highly promising techniques utilizing CRISPR/Cas9 technology. Despite the development of new therapeutic options, there still exist numerous challenges that we must face with regard to these new strategies and, consequently, we still do not have any feasible options available to ultimately slow the progression of this devastating disease. The purpose of this article is to highlight the current knowledge and advancements in the evolving paradigms in clinical pharmacology and therapeutics for this devastating musculoskeletal disease. © 2016 American Society for Clinical Pharmacology and Therapeutics.

  10. Ultimate strength of a large wind turbine blade

    Energy Technology Data Exchange (ETDEWEB)

    Moelholt Jensen, Find


    of the profile, also called 'local deformations', to verify a more complex response than that of a Bernoulli-Euler Beam. A large number of mechanical displacement sensors and strain gauges were mounted inside and outside the structure. These measurements further proved highly useful when validating Finite Element based analysis and failure mechanisms should be decided. Finally, comparisons of the ultimate failure loads observed in the full-scale tests are presented and conclusions are drawn based on the mechanisms found. (au)

  11. Ultimate resistance of a reinforced concrete foundation under impulsive loading

    International Nuclear Information System (INIS)

    Aquaro, D.; Forasassi, G.; Marconi, M.


    The impact of a spent nuclear fuel cask against a reinforced concrete slab of a temporary repository for spent nuclear fuel is numerically analysed. The analysis considers accidental events in which a spent nuclear fuel cask would drop against the floor of a repository during lifting operations. Two types of solutions have been taken into account: a simple reinforced concrete structure and a structure provided with a 40 mm thick steel liner on the impacted surface, connected to a 1600 mm thick concrete bed. The model is assumed to be axisymmetric and positioned on an elastic ground (Winkler model). The concrete has been simulated as: elastic perfectly plastic under compressive stresses limited by a crushing strain; elastic linear under tensile stresses until a cracking stress value and a following decrease of stress characterized by a constant or variable softening modulus; limited ability to resist at shear stresses after cracking characterized by a shear retention factor. The steel of the reinforcement bars and of the cask has been simulated as an elastic perfectly plastic material. Several numerical simulations have been performed in order to determine the influence, on the ultimate resistance of the structure under examination, of the steel liner, of some characteristic parameters of concrete (as the softening module and the shear retention factor) and of the Winkler coefficient values, simulating the elastic behaviour of the ground. The obtained results demonstrate that a steel liner produces a lower stress in the concrete as well as in the reinforcement but the bed is still subjected to the cracking phenomenon throughout its entire width although the crushing is localized to only a few elements near the impact zone. The use of a more complex constitutive equation for the concrete considering the shear retention factor and the softening module has given results which do not differ greatly from those related to a more simplified model. A different degree of

  12. on Goal Framing

    Directory of Open Access Journals (Sweden)

    Eulàlia P. Abril


    Full Text Available En respuesta a la enorme y algunas veces conceptualmente inconsistente literatura sobre valence framing,Levin y sus colegas (1998 desarrollaron una tipología de encuadre de valencia que organiza los diferentesresultados a partir de elección arriesgada, atributo, y encuadre de los resultados (goal framing. Este estudiofavorece la literatura sobre encuadre de los resultados mediante (a su aplicación en el contexto de una cuestiónsocial como la pobreza infantil extrema; y (b el examen de los mecanismos afectivos sobre el cual el encuadrede los resultados es de eficacia persuasiva. Los resultados experimentales (N = 197 mostraron que la exposiciónal mensaje de encuadre de pérdida permitió un apoyo mayor hacia las políticas públicas que buscan erradicar lapobreza infantil, en comparación con el mensaje de encuadre de ganancia. Los resultados también revelaronque el afecto negativo sirve como herramienta mediadora de apoyo hacia las políticas públicas. Estos hallazgossugieren que, en el contexto del apoyo social hacia la población pobre, la capacidad de persuasión dentro delencuadre de pérdida se facilita cuando los participantes experimentan afectos negativos.

  13. Treatment goals in psoriasis routine care. (United States)

    Radtke, M A; Reich, K; Spehr, C; Augustin, Matthias


    The treatment goal algorithm for psoriasis, first originated in 2007, has ever since been adopted into treatment guidelines. It remained unclear how many patients have experienced the use of treatment goals in routine care and how these are perceived. The aim of the pilot study was to get first insight in the use and impact of therapeutic goals in a large cohort of patients with psoriasis in routine care. This study is a multicenter, non-interventional, cross-sectional health care study in n = 213 dermatology centers across Germany. A standardized physician and patient questionnaire was used, including demographics, disease and treatment characteristics. To evaluate patient treatment perception and satisfaction, a questionnaire (PsoSat) addressing 8 specific items was designed. Consistency and validity of the questionnaire were controlled by factor analyses and reliability tests. In total n = 1,883 patients were included for analysis (54.2% male). Mean age was 52 years, mean disease duration 19 years. In total 45.5% (n = 856) stated an improvement of psoriatic symptoms in the last 4 weeks. In patients including treatment goals, the course of psoriasis in the last 4 weeks was rated significantly better and predicted significantly higher patient satisfaction. Patients reporting periodic outcomes measurement of psoriasis treatment, also had significantly better course of disease, higher satisfaction and a lower psoriasis severity. A majority of patients experienced the use of treatment goals in practice. The association of using treatment goals with clinical outcomes and treatment satisfaction was markedly positive. These findings indicate that the use of treatment goals and outcome measurements in fact improve psoriasis management.

  14. Goal difficulty and openness to interpersonal goal support.

    NARCIS (Netherlands)

    Righetti, F.; Kumashiro, M.; Campbell, S.


    When people pursue important goals, they are often surrounded by close others who could provide help and support for the achievement of these goals. The present work investigated whether people are more likely to be open to such interpersonal goal support from a romantic partner when they perceive

  15. 78 FR 69101 - Agency Information Collection Activities: Declaration of the Ultimate Consignee That Articles... (United States)


    ... Activities: Declaration of the Ultimate Consignee That Articles Were Exported for Temporary Scientific or... the Declaration of the Ultimate Consignee that Articles were Exported for Temporary Scientific or...: Title: Declaration of the Ultimate Consignee that Articles were Exported for Temporary Scientific or...

  16. Achievement Goals and their Underlying Goal Motivation: Does it Matter Why Sport Participants Pursue their Goals?

    Directory of Open Access Journals (Sweden)

    Patrick Gaudreau


    Full Text Available This study examined whether the good or bad outcomes associated with mastery-approach (MAP and performance-approach (PAP goals depend on the extent to which they are motivated by autonomous or controlled motivation. A sample of 515 undergraduate students who participated in sport completed measures of achievement goals, motivation of achievement goals, perceived goal attainment, sport satisfaction, and both positive and negative affect. Results of moderated regression analyses revealed that the positive relations of both MAP and PAP goals with perceived goal attainment were stronger for athletes pursuing these goals with high level of autonomous goal motivation. Also, the positive relations between PAP goals and both sport satisfaction and positive affect were stronger at high levels of autonomous goal motivation and controlled goal motivation. The shape of all these significant interactions was consistent with tenets of Self-Determination Theory as controlled goal motivation was negatively associated with positive affect and sport satisfaction and positively associated with negative affect. Overall, these findings demonstrated the importance of considering goal motivation in order to better understand the conditions under which achievement goals are associated with better experiential and performance outcomes in the lives of sport participants.

  17. Punishment goals of crime victims. (United States)

    Orth, Uli


    Research on subjective punishment goals has focused on the perspective of third-party observers of criminal offenses and neglected the perspective of victims. This study investigates punishment goals among 174 adult crime victims (rape and nonsexual assault) for each participant's real criminal case. Scales measuring support for punishment goals are constructed by factor analysis of an 18-item list. Results show that 5 highly supported goals can be distinguished: retaliation, recognition of victim status, confirmation of societal values, victim security, and societal security. Analysis of relations between punishment goal scales and personal variables, situational variables, and demanded punishment severity corroborates the view that the punishment goals revealed can be classified according to the two independent dichotomies of moral versus instrumental goals, and micro versus macro goals.

  18. BOOK REVIEW: Seeking Ultimates. An Intuitive Guide to Physics (United States)

    Brown, Neil


    Physics has the reputation of being a difficult and dry subject. Many books have been written in attempts to show that the difficulties are not insurmountable, even for the layman, and to convey some of the fascination it provides for those within it. In Seeking Ultimates Peter Landsberg avoids mathematics, the source of so many difficulties, entirely, and seeks to make physics comprehensible by what he terms intuition. He also emphasizes that there is almost no part of science that is completely understood; there are always areas of incompleteness and uncertainty, capable of providing exciting new results, and examples of this are highlighted throughout the book. After an introduction Landsberg starts with macroscopic phenomena for ease of understanding, though one might question whether the chosen topic of thermodynamics is ever going to be easy. Next he looks at microscopic effects, from atomic structure to the fundamental particles of the standard model and their interactions. There follow chapters on time and entropy, on chaos theory, on quantum mechanics and then cosmology. The final chapters look at physical constants (including the anthropic principle), whether physics has room for a creator God (the conclusion is that this is not the province of science), and some thoughts on science as a human activity. The chosen topics are those which have been important in the late twentieth century and remain important. Each chapter cites an eminent scientist as a `hero', though little is made of this. There are occasional historical notes, set in boxes, and a few short poems to leaven the text. What the book achieves is difficult to assess. Removing mathematics and adding a glossary of technical terms do not necessarily allow non-scientists to enjoy the text, as the publisher's note on the back cover suggests. The concepts can baffle the layman even more than the mathematics, and one of the most difficult of all physical concepts permeates so much of this book

  19. Teachers' goal orientations: Effects on classroom goal structures and emotions. (United States)

    Wang, Hui; Hall, Nathan C; Goetz, Thomas; Frenzel, Anne C


    Prior research has shown teachers' goal orientations to influence classroom goal structures (Retelsdorf et al., 2010, Learning and Instruction, 20, 30) and to also impact their emotions (Schutz et al., 2007, Emotion in education, Academic Press, Amsterdam, the Netherlands). However, empirical research evaluating possible causal ordering and mediation effects involving these variables in teachers is presently lacking. The present 6-month longitudinal study investigated the relations between varied motivational, behavioural, and emotional variables in practising teachers. More specifically, this study examined the reciprocal, longitudinal relations between teachers' achievement goals, classroom goal structures, and teaching-related emotions, as well as cumulative mediational models in which observed causal relations were evaluated. Participants were 495 practising teachers from Canada (86% female, M = 42 years). Teachers completed a web-based questionnaire at two time points assessing their instructional goals, perceived classroom goal structures, achievement emotions, and demographic items. Results from cross-lagged analyses and structural equation modelling showed teachers' achievement goals to predict their perceived classroom goal structures that, in turn, predicted their teaching-related emotions. The present results inform both Butler's (2012, Journal of Educational Psychology, 104, 726) theory on teachers' achievement goals and Frenzel's (2014, International handbook of emotions in education, Routledge, New York, NY) model of teachers' emotions in showing teachers' instructional goals to both directly predict their teaching-related emotions, as well as indirectly through the mediating effects of classroom goal structures. © 2016 The British Psychological Society.

  20. Teachers' Understanding of Learning Goals

    DEFF Research Database (Denmark)

    Krog Skott, Charlotte; Slot, Marie Falkesgaard; Carlsen, Dorthe

    will be presented. We expect to deepen our understanding of the relations between the various parameters in the teachers' practice in relation to learning goals and goal-oriented teaching. There is conducted research on the effects of goal-oriented teaching on students' learning both internationally...

  1. Financial Planning with Fractional Goals


    Goedhart, Marc; Spronk, Jaap


    textabstractWhen solving financial planning problems with multiple goals by means of multiple objective programming, the presence of fractional goals leads to technical difficulties. In this paper we present a straightforward interactive approach for solving such linear fractional programs with multiple goal variables. The approach is illustrated by means of an example in financial planning.

  2. Upcycling Secondary Physical Education: The Journey to Creating Goal-Oriented Courses (United States)

    Nye, Susan; Williams, Jacqueline


    The ultimate goal of a quality physical education program is to develop physically literate individuals who demonstrate skill competencies, apply knowledge, demonstrate health-enhancing behaviors, exhibit prosocial behaviors, and recognize the value of physical activity for a lifetime. The development and implementation of goal-oriented physical…

  3. The Predictiveness of Achievement Goals

    Directory of Open Access Journals (Sweden)

    Huy P. Phan


    Full Text Available Using the Revised Achievement Goal Questionnaire (AGQ-R (Elliot & Murayama, 2008, we explored first-year university students’ achievement goal orientations on the premise of the 2 × 2 model. Similar to recent studies (Elliot & Murayama, 2008; Elliot & Thrash, 2010, we conceptualized a model that included both antecedent (i.e., enactive learning experience and consequence (i.e., intrinsic motivation and academic achievement of achievement goals. Two hundred seventy-seven university students (151 women, 126 men participated in the study. Structural equation modeling procedures yielded evidence that showed the predictive effects of enactive learning experience and mastery goals on intrinsic motivation. Academic achievement was influenced intrinsic motivation, performance-approach goals, and enactive learning experience. Enactive learning experience also served as an antecedent of the four achievement goal types. On the whole, evidence obtained supports the AGQ-R and contributes, theoretically, to 2 × 2 model.

  4. (Goal Number 8) in achieving the Millennium Development Goals

    African Journals Online (AJOL)

    In 2000, the United Nations (UN) made a Millennium Declaration that commits governments across the globe to develop the lives of the people by 2015. This declaration is known as Millennium Development Goals (MDGs). This paper will examine the role that every government has to play in achieving the goals by focusing ...

  5. Systemic consultation and goal setting


    Carr, Alan


    Over two decades of empirical research conducted within a positivist framework has shown that goal setting is a particularly useful method for influencing task performance in occupational and industrial contexts. The conditions under which goal setting is maximally effective are now clearly established. These include situations where there is a high level of acceptance and commitment, where goals are specific and challenging, where the task is relatively simple rather than ...



    Yurtkoru, E. Serra; Bozkurt, Tulay; Bekta, Fatos; Ahmed, Mahir Jibril; Kola, Vehap


    The purpose of this study is to test the goal theorymodel originally developed by Locke and Latham in organizational setting inTurkey, and explain its influence on job satisfaction and affective commitment.Also mediating role of task specific strategy and moderating role ofselfefficacy are examined. Locke and Latham’s goal setting measure is adaptedto Turkish. Survey method is employed to collect data from 222 respondents fromautomotive industry. Goal setting dimensions predicted affective co...

  7. Alcohol myopia and goal commitment


    Sevincer, A. Timur; Oettingen, Gabriele


    According to alcohol myopia theory, acute alcohol consumption leads people to disproportionally focus on the salient rather than the peripheral aspects of a situation. We summarize various studies exploring how myopic processes resulting from acute alcohol intake affect goal commitment. After consuming alcohol student participants felt strongly committed to an important personal goal even though they had low expectations of successfully attaining the goal. However, once intoxicated participan...

  8. Achievement goals affect metacognitive judgments (United States)

    Ikeda, Kenji; Yue, Carole L.; Murayama, Kou; Castel, Alan D.


    The present study examined the effect of achievement goals on metacognitive judgments, such as judgments of learning (JOLs) and metacomprehension judgments, and actual recall performance. We conducted five experiments manipulating the instruction of achievement goals. In each experiment, participants were instructed to adopt mastery-approach goals (i.e., develop their own mental ability through a memory task) or performance-approach goals (i.e., demonstrate their strong memory ability through getting a high score on a memory task). The results of Experiments 1 and 2 showed that JOLs of word pairs in the performance-approach goal condition tended to be higher than those in the mastery-approach goal condition. In contrast, cued recall performance did not differ between the two goal conditions. Experiment 3 also demonstrated that metacomprehension judgments of text passages were higher in the performance-approach goal condition than in the mastery-approach goals condition, whereas test performance did not differ between conditions. These findings suggest that achievement motivation affects metacognitive judgments during learning, even when achievement motivation does not influence actual performance. PMID:28983496

  9. Goals and Personality in Adolescents (United States)

    Sanz de Acedo Lizarraga, M. L.; Ugarte, M. D.; Lumbreras, M. Victoria; Sanz de Acedo Baquedano, M. T.


    The purpose of this study was to investigate the influence of personality factors in the value allotted by adolescents to various groups of goals. For this purpose, the "Cuestionario de Personalidad Situacional, CPS" (Situational Personality Questionnaire) and the "Cuestionario de Metas para Adolescentes, CMA" (Goals for…

  10. Alcohol myopia and goal commitment

    Directory of Open Access Journals (Sweden)

    A. Timur Sevincer


    Full Text Available According to alcohol-myopia theory, acute alcohol consumption leads people to disproportionally focus on the salient rather than the peripheral aspects of a situation. We summarize various studies exploring how myopic processes resulting from acute alcohol intake affect goal commitment. After consuming alcohol student participants felt strongly committed to an important personal goal even though they had low expectations of successfully attaining the goal. However, once intoxicated participants were sober again (i.e., not myopic anymore they failed to act on their goal commitment. In line with alcohol-myopia theory, strong goal commitment as a result of alcohol intake was mediated by intoxicated (vs. sober participants disproportionally focusing on the desirability rather than the feasibility of their goal. Further supporting alcohol-myopia theory, when the low feasibility of attaining a particular goal was experimentally made salient (either explicitly or implicitly by subliminal priming, intoxicated participants felt less committed than those who consumed a placebo. We discuss these effects of acute alcohol intake in the context of research on the effects of chronic alcohol consumption on goal commitment.

  11. Goal Theory and Individual Productivity. (United States)

    Frost, Peter J.

    The paper provides a review of goal theory as articulated by Edwin Locke. The theory is evaluated in terms of laboratory and field research and its practical usefulnes is explored as a means to improving individual productivity in "real world" organizations Research findings provide support for some goal theory propositions but suggest also the…

  12. Safety goals for nuclear power

    International Nuclear Information System (INIS)

    Fischhoff, B.


    The key policy question in managing hazardous technologies is often some variant of How safe is safe enough. The US Nuclear Regulatory Commission has recently broached this topic by adopting safety goals defining acceptable risk levels for nuclear power plants. These goals are analyzed here with a general theory of standard setting (Fischhoff, 1983) which asks: (1) Are standards an appropriate policy tool in this case. (2) Can the Commission's safety philosophy be defended. (3) Do the operational goals capture that philosophy. The anlaysis shows the safety goals proposal to be sophisticated in some respects, incomplete in others. More generally, it points to difficulties with the concept of acceptable risk and any attempt to build policy instruments around it. Although focused on the NRC's safety goals, the present analysis is a prototype of what can be learned by similarly detailed consideration of other standards, not only for nuclear power but also for other hazardous technologies, as well as for issues unrelated to safety

  13. Ultimate architecture

    CERN Multimedia

    Jencks, Charles


    "European physics hothouse CERN recently unveiled Atlas, the world's most powerful particle detector, which it will use to search for the fundamental building blocks of nature from May next year. Charles Jencks describes the experience of getting up clsoe to the engineering marvel that could en up creating a mini-black hole."(5 pages with photos).

  14. Ultimate energy

    International Nuclear Information System (INIS)


    An explanation is given of the complexity faced by the scientific researcher in an effort to achieve fusion power. Outlines the theory and current experiments being pursued in this complex project, including visits to five major fusion research laboratories, and interviews with physicists

  15. Proximate and ultimate controls on carbon and nutrient dynamics of small agricultural catchments (United States)

    Thomas, Zahra; Abbott, Benjamin W.; Troccaz, Olivier; Baudry, Jacques; Pinay, Gilles


    Direct and indirect effects from human activity have dramatically increased nutrient loading to aquatic inland and estuarine ecosystems. Despite an abundance of studies investigating the impact of agricultural activity on water quality, our understanding of what determines the capacity of a watershed to remove or retain nutrients remains limited. The goal of this study was to identify proximate and ultimate controls on dissolved organic carbon and nutrient dynamics in small agricultural catchments by investigating the relationship between catchment characteristics, stream discharge, and water chemistry. We analyzed a 5-year, high-frequency water chemistry data set from three catchments in western France ranging from 2.3 to 10.8 km2. The relationship between hydrology and solute concentrations differed between the three catchments and was associated with hedgerow density, agricultural activity, and geology. The catchment with thicker soil and higher surface roughness had relatively invariant carbon and nutrient chemistry across hydrologic conditions, indicating high resilience to human disturbance. Conversely, the catchments with smoother, thinner soils responded to both intra- and interannual hydrologic variation with high concentrations of phosphate (PO43-) and ammonium (NH4+) in streams during low flow conditions and strong increases in dissolved organic carbon (DOC), sediment, and particulate organic matter during high flows. Despite contrasting agricultural activity between catchments, the physical context (geology, topography, and land-use configuration) appeared to be the most important determinant of catchment solute dynamics based on principle components analysis. The influence of geology and accompanying topographic and geomorphological factors on water quality was both direct and indirect because the distribution of agricultural activity in these catchments is largely a consequence of the geologic and topographic context. This link between inherent

  16. The establishment of MELCOR/SNAP model of Chinshan nuclear power plant for Ultimate Response Guideline

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, Wen-Sheng, E-mail: [Nuclear Science and Technology Development Center, Institute of Nuclear Engineering and Science, National Tsing Hua University, Nuclear and New Energy Education and Research Foundation, No. 101, Section 2, Kuang Fu Rd., HsinChu 30013, Taiwan, ROC (China); Chiang, Yu, E-mail: [Nuclear Science and Technology Development Center, Institute of Nuclear Engineering and Science, National Tsing Hua University, Nuclear and New Energy Education and Research Foundation, No. 101, Section 2, Kuang Fu Rd., HsinChu 30013, Taiwan, ROC (China); Wang, Jong-Rong, E-mail: [Nuclear Science and Technology Development Center, Institute of Nuclear Engineering and Science, National Tsing Hua University, Nuclear and New Energy Education and Research Foundation, No. 101, Section 2, Kuang Fu Rd., HsinChu 30013, Taiwan, ROC (China); Wang, Ting-Yi, E-mail: [Nuclear Science and Technology Development Center, Institute of Nuclear Engineering and Science, National Tsing Hua University, Nuclear and New Energy Education and Research Foundation, No. 101, Section 2, Kuang Fu Rd., HsinChu 30013, Taiwan, ROC (China); Wang, Te-Chuan, E-mail: [Institute of Nuclear Energy Research Atomic Energy Council, R.O.C., 1000, Wenhua Road Jiaan Village, Longtan Township, Taoyuan County 32546, Taiwan (China); Teng, Jyh-Tong, E-mail: [Department of Mechanical Engineering, Chung Yuan Christian University, 200, Chung Pei Rd, Chung Li 32023, Taiwan, ROC (China); Chen, Shao-Wen, E-mail: [Nuclear Science and Technology Development Center, Institute of Nuclear Engineering and Science, National Tsing Hua University, Nuclear and New Energy Education and Research Foundation, No. 101, Section 2, Kuang Fu Rd., HsinChu 30013, Taiwan, ROC (China); and others


    Highlights: • The establishment of a MELCOR/SNAP model of Chinshan (BWR/4). • MELCOR/SNAP model was used to estimate the effectiveness of URG for Chinshan. • The MELCOR results were compared to MAAP, TRACE and PCTRAN. • URG is a new method to prevent a Fukushima-like accident. • The low raw water (150 GPM) can make the cladding temperature below 1088.7 K. - Abstract: After Fukushima Daiichi disaster, the safety analysis of severe accidents became one of the safety concerns in Taiwan. The Emergency Operating Procedure (EOP) cannot cope with a multiple system failure situation under a severe accident since it is a “Symptom-basis” procedure. To deal with that, Taiwan Power Company built up a new strategy for Fukushima-like accident called Ultimate Response Guideline (URG). It is a simple strategy with three main conditions: loss of regular motor driven injection system, loss of all AC power and tsunami/earthquake warning. If two of three happen, the operating procedure will change from EOP to URG and start the main works by following the strategy. There are three main works in URG: controlled-depressurization, line up low pressure injection water and prepare containment venting. In this study, MELCOR2.1 was used to calculate the cases of URG and checked the goal of the strategy that prevents the accident or not. There were three steps in this research. First, a model of Chinshan nuclear power plant (NPP) was built. Second, one was the case with URG and the other was not by using the above MELCOR model. The results were compared to MAAP5.0, TRACE and PCTRAN. Finally, some sensitivity studies of depressurization and water injection rate were done.

  17. 75 FR 76746 - Agency Information Collection Activities: Declaration of Ultimate Consignee That Articles Were... (United States)


    ... Activities: Declaration of Ultimate Consignee That Articles Were Exported for Temporary Scientific or... That Articles Were Exported for Temporary Scientific or Educational Purposes. This is a proposed... forms of information. Title: Declaration of Ultimate Consignee That Articles Were Exported for Temporary...

  18. 7 CFR 4280.21 - Eligible REDG Ultimate Recipients and Projects. (United States)


    ... care providers; (5) Projects that utilize Advanced Telecommunications or computer networks to... 7 Agriculture 15 2010-01-01 2010-01-01 false Eligible REDG Ultimate Recipients and Projects. 4280... Economic Development Loan and Grant Programs § 4280.21 Eligible REDG Ultimate Recipients and Projects. The...

  19. 78 FR 55117 - Ultimate Heat Sink for Nuclear Power Plants; Draft Regulatory Guide (United States)


    ... NUCLEAR REGULATORY COMMISSION [NRC-2013-0203] Ultimate Heat Sink for Nuclear Power Plants; Draft... (DG), DG-1275, ``Ultimate Heat Sink for Nuclear Power Plants.'' This regulatory guide (RG) describes methods and procedures acceptable to the NRC staff that nuclear power plant facility licensees and...

  20. Career Goals in Young Adults: Personal Resources, Goal Appraisals, Attitudes, and Goal Management Strategies (United States)

    Haratsis, Jessica M.; Hood, Michelle; Creed, Peter A.


    We tested a model based on the dual-process framework that assessed the relationships among personal resources, career goal appraisals, career attitudes, and career goal management, which have not been previously assessed together. The model (tested on a sample of 486 young adults: 74% female, M[subscript]age = 22 years) proposed that personal…

  1. GOAL Agents Instantiate Intention Logic


    Hindriks, Koen; van der Hoek, Wiebe


    It is commonly believed there is a big gap between agent logics and computational agent frameworks. In this paper, we show that this gap is not as big as believed by showing that GOAL agents instantiate Intention Logic of Cohen and Levesque. That is, we show that GOAL agent programs can be formally related to Intention Logic.We do so by proving that the GOAL Verification Logic can be embedded into Intention Logic. It follows that (a fragment of) Intention Logic can be used t...

  2. Influence of cracks and pitting corrosion on residual ultimate strength of stiffened plates

    Directory of Open Access Journals (Sweden)

    ZHANG Jing


    Full Text Available [Objectives] Ships and offshore platforms serve in the harsh sea environment for a long time. Cracks and pitting corrosion will occur in such a structure and the damage will affect its ultimate strength.[Methods] To investigate the influence of cracks and pitting corrosion on ultimate bearing capacity, the ultimate strength of a structure under axial compression is studied by using a nonlinear finite element. The mesh size of a stiffened plate with cracks and pitting corrosion is first discussed. Then the influence of the relative positions of cracks and pitting corrosion, number of corrosion points and crack length impact on the residual ultimate strength of damaged stiffened plates is discussed via a series of calculations.[Results] The results indicate that the increase in crack length and pitting corrosion significantly decreases the ultimate strength of a stiffened plate. [Conclusions] This provides a useful reference for designing and maintaining ships and offshore structures in their life cycles.

  3. Ultimate capacity and influenced factors analysis of nuclear RC containment subjected to internal pressure

    International Nuclear Information System (INIS)

    Song Chenning; Hou Gangling; Zhou Guoliang


    Ultimate compressive bearing capacity, influenced factors and its rules of nuclear RC containment are key problems of safety assessment, accident treatment and structure design, etc. Ultimate compressive bearing capacity of nuclear RC containment is shown by concrete damaged plasticity model and steel double liner model of ABAQUS. The study shows that the concrete of nuclear RC containment cylinder wall becomes plastic when the internal pressure is up to 0.87 MPa, the maximum tensile strain of steel liner exceeds 3000 × 10 6 and nuclear RC containment reaches ultimate status when the internal pressure is up to 1.02 MPa. The result shows that nuclear RC containment is in elastic condition under the design internal pressure and the bearing capacity meets requirement. Prestress and steel liner play key parts in the ultimate internal pressure and failure mode of nuclear RC containment. The study results have value for the analysis of ultimate compressive bearing capacity, structure design and safety assessment. (authors)

  4. Pengaruh Goal Setting terhadap Performance : Tinjauan Teoritis


    Ginting, Surya Dharma; Ariani, D. Wahyu


    This article is the conceptual view of goal setting theory and effects of goal setting on individual performance. Goal setting is recognized, and is a major theory of work motivation. Difficult goals have consistently been shown to lead to higher levels of performance than easy goals. If there is no commitment, a goal can have no motivational effect. Goals are central to current treatments of work motivation, and goal commitment is a necessary condition for difficult goals to result in higher...

  5. A study on nonlinear behavior of reactor containment structures during ultimate accident condition(I)

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sun Hoon; Kim, Young Jin; Park, Joo Yeon [Youngdong Univ., Yeongdong (Korea, Republic of)] (and others)


    In this study, the following scope and contents are established for first year's study of determining ultimate pressure capacity of CANDU-type reactor containment. State-of-arts on the prediction of the ultimate pressure capacity of prestressed concrete reactor containment. Comparative study on structural characteristics and analysis model of CANDU-type reactor containment. State-of-arts on evaluation method of the ultimate pressure capacity of prestressed concrete reactor containment. Enhancement of evaluation method of the ultimate pressure capacity for PWR containment structure. In order to determine a realistic lower bound of a typical reactor containment structural capacity for internal pressure, modelling techniques and analytical investigation to predict its non-linear behavior up to ultimate capacity are required. Especially, the in-depth evaluation of modeling technique and analysis procedure for determining ultimate pressure capacity of CANDU-type reactor containment is required. Therefore, modelling techniques and analytical investigation to predict its non-linear behavior up to ultimate pressure capacity of CANDU-type reactor containment for internal pressure will be suggested in this study.

  6. A study on nonlinear behavior of reactor containment structures during ultimate accident condition(I)

    International Nuclear Information System (INIS)

    Kim, Sun Hoon; Kim, Young Jin; Park, Joo Yeon


    In this study, the following scope and contents are established for first year's study of determining ultimate pressure capacity of CANDU-type reactor containment. State-of-arts on the prediction of the ultimate pressure capacity of prestressed concrete reactor containment. Comparative study on structural characteristics and analysis model of CANDU-type reactor containment. State-of-arts on evaluation method of the ultimate pressure capacity of prestressed concrete reactor containment. Enhancement of evaluation method of the ultimate pressure capacity for PWR containment structure. In order to determine a realistic lower bound of a typical reactor containment structural capacity for internal pressure, modelling techniques and analytical investigation to predict its non-linear behavior up to ultimate capacity are required. Especially, the in-depth evaluation of modeling technique and analysis procedure for determining ultimate pressure capacity of CANDU-type reactor containment is required. Therefore, modelling techniques and analytical investigation to predict its non-linear behavior up to ultimate pressure capacity of CANDU-type reactor containment for internal pressure will be suggested in this study

  7. Empowerment: a goal or a means for health promotion? (United States)

    Tengland, Per-Anders


    Empowerment is a concept that has been much used and discussed for a number of years. However, it is not always explicitly clarified what its central meaning is. The present paper intends to clarify what empowerment means, and relate it to the goals of health promotion. The paper starts with the claim that health-related quality of life is the ultimate general goal for health promotion, and continues by briefly presenting definitions of some central concepts: "welfare", "health" and "quality of life". Several suggestions as to what empowerment is are then discussed: autonomy, freedom, knowledge, self-esteem, self-confidence, and control over health or life. One conclusion of this discussion is that empowerment can be seen as a complex goal which includes aspects of the three central concepts welfare, health and quality of life. To the extent that the empowerment goals aimed at are health-related, it is concluded that empowerment is a legitimate goal for health promotion. But empowerment is not only a goal, it can also be described as a process or as an approach. This process, or approach, in a fundamental way involves the participants in problem formulation, decision making and action, which means that the experts have to relinquish some of their control and power.

  8. Seismic shear wall ISP NUPEC's seismic ultimate dynamic response test. Comparison report

    International Nuclear Information System (INIS)


    In the seismic design of a nuclear power plant, evaluation of the ultimate strength of the nuclear reactor building is an important subject for assessment of seismic reliability of the plant. In order to carry out the evaluation, the response characteristics of reinforced concrete seismic shear walls up to their ultimate state have to be understood. For this purpose, there is a need to develop reliable non-linear response analysis methods which enables the reliable ultimate strength evaluation of nuclear reactor buildings. Along with this need, many computer codes have been developed. These computer codes are compared. (K.A.)

  9. A therapeutic HIV vaccine using coxsackie-HIV recombinants: a possible new strategy. (United States)

    Halim, S S; Collins, D N; Ramsingh, A I


    The ultimate goal in the treatment of HIV-infected persons is to prevent disease progression. A strategy to accomplish this goal is to use chemotherapy to reduce viral load followed by immunotherapy to stimulate HIV-specific immune responses that are observed in long-term asymptomatic individuals. An effective, live, recombinant virus, expressing HIV sequences, would be capable of inducing both CTL and CD4(+) helper T cell responses. To accomplish these goals, the viral vector must be immunogenic yet retain its avirulent phenotype in a T cell-deficient host. We have identified a coxsackievirus variant, CB4-P, that can induce protective immunity against a virulent variant. In addition, the CB4-P variant remains avirulent in mice lacking CD4(+) helper T cells, suggesting that CB4-P may be uniquely suited as a viral vector for a therapeutic HIV vaccine. Two strategies designed to elicit CTL and CD4(+) helper T cell responses were used to construct CB4-P/HIV recombinants. Recombinant viruses were viable, genetically stable, and retained the avirulent phenotype of the parental virus. In designing a viral vector for vaccine development, an issue that must be addressed is whether preexisting immunity to the vector would affect subsequent administration of the recombinant virus. Using a test recombinant, we showed that prior exposure to the parental CB4-P virus did not affect the ability of the recombinant to induce a CD4(+) T cell response against the foreign sequence. The results suggest that a "cocktail" of coxsackie/HIV recombinants may be useful as a therapeutic HIV vaccine.

  10. Power assistant systems as the ultimate goal. Exchanging meters is not enough; Energieassistenzsysteme als Zielsetzung. Wer nur an den Zaehleraustausch denkt, hat schon verloren

    Energy Technology Data Exchange (ETDEWEB)

    Hein, Franz [mpc Management Project Coaching, Esslingen (Germany)


    In the cost-profit calculation, the energy advantage of power assistant systems must be higher than their power consumption. It is inacceptable to regard only the views of individual market partners or only certain time periods during a system's life. Purely monetary considerations are off the mark because no amount of money can buy a new environment for mankind. The current one is the only one we have. (orig.)

  11. Goal-Oriented Ethics: Framing the Goal-Setting Concretely

    Directory of Open Access Journals (Sweden)

    Mathew Illathuparampil


    Full Text Available Joseph Selling, professor emeritus from KU Leuven, Belgium, recently made a significant contribution towards ethical methodology. It is in fact a continuation of the in-house conversations that have been in vogue about methods in moral reasoning since Vatican II in the discipline called theological ethics. What is specific about Selling’s attempt is that he re-orients or reframes the evaluation of the moral event to consider human intentionality or motivation before considering human behavior or human acts. He convincingly establishes his method by a meticulous reading of Thomas Aquinas. This paper is a response to the goal-oriented ethics that he has posited. As illustrated below, this paper evaluates the goal-oriented approach as solid and sufficient. While fully endorsing this approach, this paper argues that the process of ethical goal-setting is to be framed concretely. In a concrete historical context, so that a goal-oriented approach fully serves its purpose, this paper proposes that it is to be reinforced by four supportive pillars, which are in fact assumed by Selling in his work. They are openness to human sciences, conversation among various narratives, positing a theological frame for ethical reasoning, and recourse to non-discursive reasoning.

  12. Defining safety goals. 2. Basic Consideration on Defining Safety Goals

    International Nuclear Information System (INIS)

    Hakata, T.


    The purpose of this study is to develop basic safety goals that are rational and consistent for all nuclear facilities, including nuclear power plants and fuel cycle facilities. Basic safety goals (risk limits) by an index of radiation dose are discussed, which are based on health effects of detriment and fatality and risk levels presumably accepted by society. The contents of this paper are the personal opinions of the author. The desirable structure of safety goals is assumed to be 'basic safety goals plus specific safety goals (or supplemental safety goals) for each sort of facility, which reflects their characteristics'. The requisites of the basic safety goals must include (a) rational bases (scientific and social), (b) comprehensiveness (common to all sorts of nuclear facilities covering from normal to accidental conditions), and (c) applicability. To meet the requirements, the basic safety goals might have to be a risk profile expression by an index of radiation dose. The societal rationality is consideration of absolute risk levels (10 -6 or 10 -7 /yr) and/or relative risk factors (such as 0.1% of U.S. safety goals) that the general public accepts as tolerable. The following quantitative objectives are adopted in this study for protection of average individuals in the vicinity of a nuclear facility: 1. The additive annual radiation dose during normal operation must be -4 /yr (health detriment), 2x10 -6 /yr (latent cancer and severe hereditary effects), and 10 -7 /yr (acute fatality) from the statistics in Japan. The radiation effects on human beings are determined by recommendations of UNSCEAR (Ref. 1) and ICRP. The health effects considered are non-severe stochastic health detriment, i.e., detectable opacities of lens of eye (threshold 5 0.5 to 2 Sv), depression of hematopoiesis of bone marrow (0.5 Sv), and depression of reproductive capability (temporary sterility of testes ) (0.15 Sv). The LD 50/60 of acute fatality is ∼4 Sv, and fatalities by latent

  13. Ultimate Bound of a 3D Chaotic System and Its Application in Chaos Synchronization

    Directory of Open Access Journals (Sweden)

    Jiezhi Wang


    Full Text Available Two ellipsoidal ultimate boundary regions of a special three-dimensional (3D chaotic system are proposed. To this chaotic system, the linear coefficient of the ith state variable in the ith state equation has the same sign; it also has two one-order terms and one quadratic cross-product term in each equation. A numerical solution and an analytical expression of the ultimate bounds are received. To get the analytical expression of the ultimate boundary region, a new result of one maximum optimization question is proved. The corresponding ultimate boundary regions are demonstrated through numerical simulations. Utilizing the bounds obtained, a linear controller is proposed to achieve the complete chaos synchronization. Numerical simulation exhibits the feasibility of the designed scheme.

  14. LRFD software for design and actual ultimate capacity of confined rectangular columns. (United States)


    The analysis of concrete columns using unconfined concrete models is a well established practice. On the : other hand, prediction of the actual ultimate capacity of confined concrete columns requires specialized nonlinear : analysis. Modern codes and...

  15. [Deniss Hanovs, Valdis Tēraudkalns: Ultimate Freedom - no choice] / Olaf Mertelsmann

    Index Scriptorium Estoniae

    Mertelsmann, Olaf, 1969-


    Arvustus: Deniss Hanovs, Valdis Tēraudkalns: Ultimate Freedom - no choice. The culture of authoritarianism in Latvia, 1934-1940. (Central and Eastern Europe. Reginal perspectives in global context, Bd. 2.) Brill. Leiden-Boston 2013

  16. Reduced design load basis for ultimate blade loads estimation in multidisciplinary design optimization frameworks

    DEFF Research Database (Denmark)

    Pavese, Christian; Tibaldi, Carlo; Larsen, Torben J.


    The aim is to provide a fast and reliable approach to estimate ultimate blade loads for a multidisciplinary design optimization (MDO) framework. For blade design purposes, the standards require a large amount of computationally expensive simulations, which cannot be efficiently run each cost...... function evaluation of an MDO process. This work describes a method that allows integrating the calculation of the blade load envelopes inside an MDO loop. Ultimate blade load envelopes are calculated for a baseline design and a design obtained after an iteration of an MDO. These envelopes are computed...... for a full standard design load basis (DLB) and a deterministic reduced DLB. Ultimate loads extracted from the two DLBs with the two blade designs each are compared and analyzed. Although the reduced DLB supplies ultimate loads of different magnitude, the shape of the estimated envelopes are similar...

  17. Recommendation for basis for decision on a Danish ultimate storage for low and intermediate radioactive wastes

    International Nuclear Information System (INIS)


    In 2003 the Danish Parliament consented to let the government start the preparation of a basis for decision on a Danish ultimate storage for low and intermediate radioactive wastes. The present report is the result of the preparation process, and it describes the fundamental safety and environmental principles for establishing an ultimate storage, including determining the principles for the site selection, storage construction, and safety analyses. (LN)

  18. A Technique for Temperature and Ultimate Load Calculations of Thin Targets in a Pulsed Electron Beam

    DEFF Research Database (Denmark)

    Hansen, Jørgen-Walther; Lundsager, Per


    A technique is presented for the calculation of transient temperature distributions and ultimate load of rotationally symmetric thin membranes with uniform lateral load and exposed to a pulsed electron beam from a linear accelerator. Heat transfer by conduction is considered the only transfer...... mechanism. The ultimate load is calculated on the basis of large plastic strain analysis. Analysis of one aluminum and one titanium membrane is shown....

  19. Goal Setting as Teacher Development Practice (United States)

    Camp, Heather


    This article explores goal setting as a teacher development practice in higher education. It reports on a study of college teacher goal setting informed by goal setting theory. Analysis of study participants' goal setting practices and their experiences with goal pursuit offers a framework for thinking about the kinds of goals teachers might set…

  20. Educational attainment and ultimate fertility among Swedish women born in 1955-59

    Directory of Open Access Journals (Sweden)

    Gerda Neyer


    Full Text Available This is the second of two companion papers addressing the association between educational attainment and fertility for some sixty educational groups of Swedish women, defined according to field of education as well as level of education. The first paper is about childlessness and education, the present one about the mean number of children ever born. We find that ultimate fertility decreases somewhat with an increasing educational level, but its dependence on the field of education is much more impressive. In general, educational groups with relatively little childlessness also have relatively high ultimate fertility, and educational groups with much childlessness have relatively low ultimate fertility. In particular, women educated for the teaching or health-care professions have less childlessness and a higher ultimate fertility than others. Conversely, women with an education for esthetic or (non-teacher humanist occupations have unusually high fractions childless and low ultimate fertility. Women with religious educations stand out by having very high fractions childless but quite ordinary mean ultimate fertility nevertheless; such women have very little childbearing outside of marriage. Women with research degrees have remarkably ordinary childbearing behavior; they do not forego motherhood to the extent that some theories would predict.

  1. Excess glycogen does not resolve high ultimate pH of oxidative muscle. (United States)

    England, Eric M; Matarneh, Sulaiman K; Oliver, Emily M; Apaoblaza, Ariel; Scheffler, Tracy L; Shi, Hao; Gerrard, David E


    Skeletal muscle glycogen content can impact the extent of postmortem pH decline. Compared to glycolytic muscles, oxidative muscles contain lower glycogen levels antemortem which may contribute to the higher ultimate pH. In an effort to explore further the participation of glycogen in postmortem metabolism, we postulated that increasing the availability of glycogen would drive additional pH decline in oxidative muscles to equivalent pH values similar to the ultimate pH of glycolytic muscles. Glycolysis and pH declines were compared in porcine longissimus lumborum (glycolytic) and masseter (oxidative) muscles using an in vitro system in the presence of excess glycogen. The ultimate pH of the system containing longissimus lumborum reached a value similar to that observed in intact muscle. The pH decline of the system containing masseter samples stopped prematurely resulting in a higher ultimate pH which was similar to that of intact masseter muscle. To investigate further, we titrated powdered longissimus lumborum and masseter samples in the reaction buffer. As the percentage of glycolytic sample increased, the ultimate pH decreased. These data show that oxidative muscle produces meat with a high ultimate pH regardless of glycogen content and suggest that inherent muscle factors associated with glycolytic muscle control the extent of pH decline in pig muscles. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Assessment on Ultimate Load of Cold-formed Steel Channel (CFSC Stub Column

    Directory of Open Access Journals (Sweden)

    Mohd Sani Mohd Syahrul Hisyam


    Full Text Available Cold-formed steel is used as the non-structural and structural material in civil engineering work and building. Cold-formed steel channel is selected and cut into 100 mm, 200 mm, 300 mm, 400 mm and 500 mm. The slenderness ratio is calculated and noted as a stub or short column because below 40. The column is tested by using Universal Testing Machine to determine the ultimate load of the stub column. Besides, the CFSC is determined the material properties of CFSC for checking it’s the originality of steel based material. The experimental data are tested and compared with the Direct Strength Method (DSM. It showed that the CFSC1 with a height of 100 mm is reported to have a higher value of ultimate load when compared with other samples. When the height of the stub column increased, the ultimate load of the sample is decreased. Then, the CFSC1 also showed a higher in initial stiffness when compared with other samples. All samples are shown having a higher data in ultimate load when compared with the Direct Strength Method prediction. The ultimate load of experimental and DSM all gave a ratio below 1.03. Finally, all samples can further recommend determining the relation between the ultimate loads with variations of height of the column.

  3. Goals for nuclear waste management

    International Nuclear Information System (INIS)

    Watson, R.A.


    Establishing a publicly, politically, economically, and technologically acceptable waste management system for the fuel cycle is a necessary condition for accepting the nuclear program as a national energy option. Findings are given on the technology, politics, economics, morality, aesthetics, and societal impact of waste management. Proposed goals are outlined for the regulation of waste management

  4. New Goals of Sustainable Future

    Directory of Open Access Journals (Sweden)

    Arkady Ursul


    Full Text Available This article investigates the process of transition from the Millennium Development Goals to Sustainable Development Goals (SDGs. The authors have set an objective to demonstrate that SD as a future form of development of civilization from the very beginning had a “target orientation” and from the beginning and anticipated realization and staging of the whole hierarchy of objectives needed for the establishment of an effective global governance. In the future, global development in its “anthropogenic” aspect will be to implement the goals and principles of SD, which will be updated with each new stage of the implementation of this kind of socio-natural evolution. The paper argues the position that the concept of SD should be radically transformed into a “global dimension.” Attention is drawn to the fact that Russia recognized another distant, but very important in the conceptual and theoretical perspective, global goal of “sustainable transition” — formation of the noosphere.

  5. A Goal for Nursing Education. (United States)

    Marcinkiw, Karen L.


    Culturally competent nurses enable clients to feel respected, valued, and motivated to achieve health goals. A model for nursing education should develop cultural awareness, knowledge, and skills; provide cultural immersion experiences; and foster the desire to work with diverse clients. (Contains 48 references.) (SK)

  6. Relations between Classroom Goal Structures and Students' Goal Orientations in Mathematics Classes: When Is a Mastery Goal Structure Adaptive? (United States)

    Skaalvik, Einar M.; Federici, Roger A.


    The purpose of this study was to test possible interactions between mastery and performance goal structures in mathematics classrooms when predicting students' goal orientations. More specifically, we tested if the degree of performance goal structure moderated the associations between mastery goal structure and students' goal orientations.…

  7. [Treatment goals in FACE philosophy]. (United States)

    Martin, Domingo; Maté, Amaia; Zabalegui, Paula; Valenzuela, Jaime


    The FACE philosophy is characterized by clearly defined treatment goals: facial esthetics, dental esthetics, periodontal health, functional occlusion, neuromuscular mechanism and joint function. The purpose is to establish ideal occlusion with good facial esthetics and an orthopedic stable joint position. The authors present all the concepts of FACE philosophy and illustrate them through one case report. Taking into account all the FACE philosophy concepts increases diagnostic ability and improves the quality and stability of treatment outcomes. The goal of this philosophy is to harmonize the facial profile, tooth alignment, periodontium, functional occlusion, neuromuscular mechanism and joint function. The evaluation and treatment approach to vertical problems are unique to the philosophy. © EDP Sciences, SFODF, 2017.

  8. Motivational beliefs, values, and goals. (United States)

    Eccles, Jacquelynne S; Wigfield, Allan


    This chapter reviews the recent research on motivation, beliefs, values, and goals, focusing on developmental and educational psychology. The authors divide the chapter into four major sections: theories focused on expectancies for success (self-efficacy theory and control theory), theories focused on task value (theories focused on intrinsic motivation, self-determination, flow, interest, and goals), theories that integrate expectancies and values (attribution theory, the expectancy-value models of Eccles et al., Feather, and Heckhausen, and self-worth theory), and theories integrating motivation and cognition (social cognitive theories of self-regulation and motivation, the work by Winne & Marx, Borkowski et al., Pintrich et al., and theories of motivation and volition). The authors end the chapter with a discussion of how to integrate theories of self-regulation and expectancy-value models of motivation and suggest new directions for future research.

  9. Iterative Goal Refinement for Robotics (United States)


    Researchers have used a variety of ways to represent such constraints (e.g., as a constraint satisfaction problem ( Scala , to appear), in PDDL (Vaquro...lifecycle to recent models of replanning (Talamadupala et al., 2013) and continual planning ( Scala , to appear). We described goal reasoning in...F., & Barreiro, J. (2013). Towards deliberative control in marine robotics. In Marine Robot Autonomy (pp. 91–175). Springer. Scala , E. (to appear

  10. Physics goals of future colliders

    International Nuclear Information System (INIS)

    Kane, G.L.


    These lectures describe some of the physics goals that future colliders are designed to achieve. Emphasis is on the SSC, but its capabilities are compared to those of other machines, and set in a context of what will be measured before the SSC is ready. Physics associated with the Higgs sector is examined most thoroughly, with a survey of the opportunities to find evidence of extended gauge theories

  11. Therapeutic targets in liver fibrosis. (United States)

    Fallowfield, Jonathan A


    Detailed analysis of the cellular and molecular mechanisms that mediate liver fibrosis has provided a framework for therapeutic approaches to prevent, slow down, or even reverse fibrosis and cirrhosis. A pivotal event in the development of liver fibrosis is the activation of quiescent hepatic stellate cells (HSCs) to scar-forming myofibroblast-like cells. Consequently, HSCs and the factors that regulate HSC activation, proliferation, and function represent important antifibrotic targets. Drugs currently licensed in the US and Europe for other indications target HSC-related components of the fibrotic cascade. Their deployment in the near future looks likely. Ultimately, treatment strategies for liver fibrosis may vary on an individual basis according to etiology, risk of fibrosis progression, and the prevailing pathogenic milieu, meaning that a multiagent approach could be required. The field continues to develop rapidly and starts to identify exciting potential targets in proof-of-concept preclinical studies. Despite this, no antifibrotics are currently licensed for use in humans. With epidemiological predictions for the future prevalence of viral, obesity-related, and alcohol-related cirrhosis painting an increasingly gloomy picture, and a shortfall in donors for liver transplantation, the clinical urgency for new therapies is high. There is growing interest from stakeholders keen to exploit the market potential for antifibrotics. However, the design of future trials for agents in the developmental pipeline will depend on strategies that enable equal patient stratification, techniques to reliably monitor changes in fibrosis over time, and the definition of clinically meaningful end points.

  12. The contribution of goal specificity to goal achievement in collaborative goal setting for the management of asthma. (United States)

    Smith, Lorraine; Alles, Chehani; Lemay, Kate; Reddel, Helen; Saini, Bandana; Bosnic-Anticevich, Sinthia; Emmerton, Lynne; Stewart, Kay; Burton, Debbie; Krass, Ines; Armour, Carol


    Goal setting was investigated as part of an implementation trial of an asthma management service (PAMS) conducted in 96 Australian community pharmacies. Patients and pharmacists identified asthma-related issues of concern to the patient and collaboratively set goals to address these. Although goal setting is commonly integrated into disease state management interventions, the nature of goals, and their contribution to goal attainment and health outcomes are not well understood. To identify and describe: 1) goals set collaboratively between adult patients with asthma and their pharmacist, 2) goal specificity and goal achievement, and 3) describe the relationships between specificity, achievement, asthma control and asthma-related quality of life. Measures of goal specificity, and goal achievement were developed and applied to patient data records. Goals set were thematically analyzed into goal domains. Proportions of goals set, goals achieved and their specificity were calculated. Correlational and regression analyses were undertaken to determine the relationships between goal specificity, goal achievement, asthma control and asthma-related quality of life. Data were drawn from 498 patient records. Findings showed that patients set a wide range and number of asthma-related goals (N = 1787) and the majority (93%) were either achieved or being working toward by the end of the study. Goal achievement was positively associated with specific and moderately specific goals, but not non-specific goals. However, on closer inspection, an inconsistent pattern of relationships emerged as a function of goal domain. Findings also showed that goal setting was associated with end-of-study asthma control but not to asthma-related quality of life. Pharmacists can help patients to set achievable and specific asthma management goals, and these have the potential to directly impact health outcomes such as asthma control. Goal specificity appears to be an important feature in the

  13. The interaction between dietary and life goals: using goal systems theory to explore healthy diet and life goals. (United States)

    Turner-McGrievy, Gabrielle M; Wright, Julie A; Migneault, Jeffrey P; Quintiliani, Lisa; Friedman, Robert H


    Objective : To examine the types of life and dietary goals individuals report and how these goal domains interact as framed by goal systems theory. Methods : This work is a cross-sectional survey study. Measures included the incidence of common life and dietary goals and how these goals interact with and facilitate each other. Results : The results of a quantitative survey ( n  = 46 participants), which was informed by two focus groups ( n  = 17 participants), showed that participants are trying to achieve several different life (e.g. achieving financial success) and dietary goals (e.g. eating more fruits and vegetables, drinking more water, and losing weight) and that these two types of goals interact to both facilitate and conflict with each other. Having a life goal of exercising was significantly associated with healthy eating goals when compared with other life goals ( p 's goals may be linked and help to facilitate one another. Being in the maintenance phase with the goal of healthy eating was associated with participants feeling like they were more successful in their other non-diet-related health goals ( p  goals can facilitate success in achieving other goals. Conclusions : Life goals can have an impact on a person's ability to achieve and maintain dietary and other health goals. Health educators may help to facilitate long-term behavior change by examining a person's life goals as well as dietary goals.

  14. Novel therapeutic approaches in chondrosarcoma. (United States)

    Polychronidou, Genovefa; Karavasilis, Vasilios; Pollack, Seth M; Huang, Paul H; Lee, Alex; Jones, Robin L


    Chondrosarcoma is a malignant tumor of bones, characterized by the production of cartilage matrix. Due to lack of effective treatment for advanced disease, the clinical management of chondrosarcomas is exceptionally challenging. Current research focuses on elucidating the molecular events underlying the pathogenesis of this rare bone malignancy, with the goal of developing new molecularly targeted therapies. Signaling pathways suggested to have a role in chondrosarcoma include Hedgehog, Src, PI3k-Akt-mTOR and angiogenesis. Mutations in IDH1/2, present in more than 50% of primary conventional chondrosarcomas, make the development of IDH inhibitors a promising treatment option. The present review discusses the preclinical and early clinical data on novel targeted therapeutic approaches in chondrosarcoma.

  15. Therapeutic options for lip augmentation. (United States)

    Segall, Lorne; Ellis, David A F


    Aesthetic ideals vary with emerging fashion trends and within different cultures. However, over the past few decades, fuller lips have been considered a desirable trait. Many younger patients are presenting for lip augmentation to achieve the sought-after look commonly seen in many fashion magazines. In addition, as individuals age, they lose lip volume, with a thinning of the red lip, some effacement of the vermillion border, and elongation and flattening of the white portion of the lip. Rejuvenation of the lips plays a key role in restoring a more youthful appearance. As a result, lip augmentation appeals to a wide spectrum of patients who present with various different aesthetic goals and expectations. Numerous therapeutic options exist for aesthetic lip augmentation, ranging from temporary and permanent injectable fillers to implants and other surgical techniques.

  16. Ultimate dynamics of the Kirschner-Panetta model: Tumor eradication and related problems (United States)

    Starkov, Konstantin E.; Krishchenko, Alexander P.


    In this paper we consider the ultimate dynamics of the Kirschner-Panetta model which was created for studying the immune response to tumors under special types of immunotherapy. New ultimate upper bounds for compact invariant sets of this model are given, as well as sufficient conditions for the existence of a positively invariant polytope. We establish three types of conditions for the nonexistence of compact invariant sets in the domain of the tumor-cell population. Our main results are two types of conditions for global tumor elimination depending on the ratio between the proliferation rate of the immune cells and their mortality rate. These conditions are described in terms of simple algebraic inequalities imposed on model parameters and treatment parameters. Our theoretical studies of ultimate dynamics are complemented by numerical simulation results.

  17. Revisiting perceptions of quality of hospice care: managing for the ultimate referral. (United States)

    Churchman, Richard; York, Grady S; Woodard, Beth; Wainright, Charles; Rau-Foster, Mary


    Hospice services provided in the final months of life are delivered through complex interpersonal relationships between caregivers, patients, and families. Often, service value and quality are defined by these interpersonal interactions. This understanding provides hospice leaders with an enormous opportunity to create processes that provide the optimal level of care during the last months of life. The authors argue that the ultimate referral is attained when a family member observes the care of a loved one, and the family member conveys a desire to receive the same quality of services their loved one received at that facility. The point of this article is to provide evidence that supports the methods to ultimately enhance the patient's and family's experience and increase the potential for the ultimate referral. © The Author(s) 2013.

  18. Ultimate Owner and Firm Performance - Evidence from Romanian Mining and Quarrying Listed Firms

    Directory of Open Access Journals (Sweden)

    Cosmin MIHAI


    Full Text Available The main objectives of this paper are to describe the necessary steps to identify the ultimate owner and to investigate the relation between the ultimate ownership and the financial performance of Romanian mining and quarrying listed firms. The study was conducted for the companies listed on Bucharest Stock Exchange, in both regulated and non-regulated segments. The final sample included 17 companies of mining and quarrying. Return on Equity was used for measuring the financial performance of the firms. The ultimate ownership was measured by the percentage of voting rights held by a shareholder. Econometric tools like multiple linear regression analysis were used for analysis. The results of the study suggest that there is a significant negative link between financial performance and divergence between voting rights and cash-flow rights.

  19. The importance of mines for ultimate storage at Deilmann-Haniel Shaft Sinking

    International Nuclear Information System (INIS)

    Greinacher, Jochen; Oellers, Thomas; Ahlbrecht, Thomas


    Deilmann-Haniel Shaft Sinking GmbH and its predecessor and associate companies have been involved in projects for underground ultimate storage in Germany, Europe and America for over 45 years. The field of activities previously comprised surveying, planning and sinking of shafts, repair and conversion work, design of underground sealing structures, planning of conveyors and support of the BfS in planning approval procedures. Following discontinuation of activities in the German coal mining industry the use of mines for ultimate storage is an important support for German specialist mining companies. The use of mines for ultimate storage ensures that the existing mining know how in Germany is maintained, because training of the younger generation on the commercial and engineering side of the companies is made possible by the imminent major projects.

  20. On the decrease of ultimate elongation of gum elastomer by irradiation

    International Nuclear Information System (INIS)

    Ito, Masayuki


    The reason why the ultimate elongation of gum elastomer decreases by irradiation was studied. The sample used is tetrafluoroethylenepropylene copolymer vulcanized which is a heat resistant elastomer. The sample was irradiated by a electron beam at room temperature. Cross-linking predominate in the operation. (Case 1) Scission predominant condition (Case 2) was given by irradiation of Co-60 γ ray at 100 deg C. Alternative irradiation of γ ray and electron beam under above condition can keep the original cross-linking density by the appropriate choice of each of the doses. (Case 3) The three cases mentioned above involve all of the cases of radiation induced aging of elastomers. Therefor, the following explanation for three cases shows the reason why the ultimate elongation of gum elastomer decreases by irradiation. Case 1. Cross-linking predominant condition. Ultimate elongation is proportional to -0.5 power of the dose. This fact can be explicable by the model of Buche, i.e. the breaking of a short chain causes another to break and that so on throughout the whole sample. Case 2. Chain scission predominant condition. Ultimate elongation increases by irradiation for a certain dose. This fact can understand by the model of Buche. But from a certain dose ultimate elongation does not increase. In the period the structure of the sample turned to be the same structure as the low molecular weight amorphose polymer vulcanized. Case 3. Rate of cross-linking and scission is the same. The average chain length does not chainge in the condition. But the distribution of chain length became wider and wider by irradiation. The increase of short chain result the decrease in ultimate elongation. (author)

  1. [Therapeutic Aggressiveness and Liquid Oncology]. (United States)

    Barón Duarte, F J; Rodríguez Calvo, M S; Amor Pan, J R


    Aggressiveness criteria proposed in the scientific literature a decade ago provide a quality judgment and are a reference in the care of patients with advanced cancer, but their use is not generalized in the evaluation of Oncology Services. In this paper we analyze the therapeutic aggressiveness, according to standard criteria, in 1.001 patients with advanced cancer who died in our Institution between 2010 and 2013. The results seem to show that aggressiveness at the end of life is present more frequently than experts recommend. About 25% of patients fulfill at least one criterion of aggressiveness. This result could be explained by a liquid Oncology which does not prioritize the patient as a moral subject in the clinical appointment. Medical care is oriented to necessities and must be articulated in a model focused on dignity and communication. Its implementation through Advanced Care Planning, consideration of patient's values and preferences, and Limitation of therapeutic effort are ways to reduce aggressiveness and improve clinical practice at the end of life. We need to encourage synergic and proactive attitudes, adding the best of cancer research with the best clinical care for the benefit of human being, moral subject and main goal of Medicine.

  2. Ultimate strength and ductility of steel reinforced concrete beam-columns

    International Nuclear Information System (INIS)

    Shohara, Ryoichi


    The ultimate strength and ductility of SRC beam-columns are investigated using the data gathered in Architectural Institute of Japan. Though the simple superposed strength formula in AIJ standard underestimates the strength of SRC beam-column failed in flexure, the generalized superposed strength formula estimates it satisfactory. The strength formula in AIJ standard does not good agreement with test data. The SRC beam-column failed in shear has almost equalductility with that failed in flexure owing to the encased steel. Author presents the formulas which estimate the ultimate deformation angle for SRC beam-columns. (author)

  3. Maintained ship hull girder ultimate strength reliability considering corrosion and fatigue

    DEFF Research Database (Denmark)

    Hu, Yong; Cui, W.; Pedersen, Preben Terndrup


    The prupose of this paper is to propose a methodology to assess the time-variant ultimate strength of ship hull girder under the degradations of corrosion and fatigue. The effects of fatigue cracks on the tensile and compressive residual ultimate strength of stiffened panels and unstiffened plates......, webs and flanges, respectively. The effects of inspections and repair are taken into account. A minimum net thickness rule is used to determine repair policies. A procedure is proposed to determine the maximum allowable corrosion thickness of different parts of the hull cross section. The procedure...

  4. Behaviour of concrete nuclear containment structures upto ultimate failure with special reference to MAPP-1 containment

    International Nuclear Information System (INIS)

    Appa Rao, T.V.S.R.


    Theoretical and experimental methods for investigating the behaviour of concrete secondary containment structures subjected to loads upto their ultimate failure have been discussed in the paper. Need for inelastic nonlinear analysis of containments has been emphasized. Different contitutive models of concrete that can be employed in the nonlinear analysis of concrete structures were briefly reviewed. Based on the experimental results obtained in a 1:12 scale model test conducted at the Structural Engineering Research (Regional) Centre, Madras, behaviour of the MAPP-1 containment to internal pressure loading upto its ultimate failure has been discussed. (author)

  5. Decision basis for a Danish ultimate storage for low and intermediate radioactive wastes

    International Nuclear Information System (INIS)


    In 2003 the Danish Parliament consented to let the government start the preparation of a basis for decision on a Danish ultimate storage for low and intermediate radioactive wastes. The present report was prepared by a working group and it presents the final proposal for such a decision basis. The report describes the fundamental safety and environmental principles for establishing an ultimate storage, including determining the principles for site selection, storage construction, and safety analysis. In an appendix, the amount, types, and activity level of the Danish radioactive wastes are presented. (ln)

  6. Conception of electron beam-driven subcritical molten salt ultimate safety reactor

    Energy Technology Data Exchange (ETDEWEB)

    Abalin, S.S.; Alekseev, P.N.; Ignat`ev, V.V. [Kurchatov Institute, Moscow (Russian Federation)] [and others


    This paper is a preliminary sketch of a conception to develop the {open_quotes}ultimate safety reactor{close_quotes} using modern reactor and accelerator technologies. This approach would not require a long-range R&D program. The ultimate safety reactor could produce heat and electric energy, expand the production of fuel, or be used for the transmutation of long-lived wastes. The use of the combined double molten salt reactor system allows adequate neutron multiplication to permit using an electron accelerator for the initial neutron flux. The general parameters of such a system are discussed in this paper.

  7. Dynamics of multiple-goal pursuit. (United States)

    Louro, Maria J; Pieters, Rik; Zeelenberg, Marcel


    The authors propose and test a model of multiple-goal pursuit that specifies how individuals allocate effort among multiple goals over time. The model predicts that whether individuals decide to step up effort, coast, abandon the current goal, or switch to pursue another goal is determined jointly by the emotions that flow from prior goal progress and the proximity to future goal attainment, and proximally determined by changes in expectancies about goal attainment. Results from a longitudinal diary study and 2 experiments show that positive and negative goal-related emotions can have diametrically opposing effects on goal-directed behavior, depending on the individual's proximity to goal attainment. The findings resolve contrasting predictions about the influence of positive and negative emotions in volitional behavior, critically amend the goal gradient hypothesis, and provide new insights into the dynamics and determinants of multiple-goal pursuit.

  8. Update on therapeutic management of idiopathic pulmonary fibrosis (United States)

    Tzouvelekis, Argyris; Bonella, Francesco; Spagnolo, Paolo


    Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive diffuse parenchymal lung disease of unknown origin, with a mortality rate exceeding that of many cancers. The diagnostic process is complex and relies on the clinician integrating clinical, laboratory, radiological, and histological data. In the last decade, major advances in our understanding of the pathogenesis of IPF have shifted the paradigm from a primarily inflammatory process evolving to fibrosis to a condition driven by aberrant wound healing following alveolar epithelial cell injury that results in scarring of the lung, architectural distortion, and irreversible loss of function. Improved understanding of disease pathogenesis has led to the identification of several therapeutic targets and the design of high-quality clinical trials evaluating novel compounds. However, the results of these studies have been mostly disappointing, probably due to the plethora of mediators, growth factors, and signaling pathways involved in the fibrotic process. Most recently, pirfenidone and nintedanib, two compounds with pleiotropic anti-fibrotic properties, have been proven effective in reducing functional decline and disease progression in IPF. This is a major breakthrough. Nevertheless, we still have a long way to go. In fact, neither pirfenidone nor nintedanib is a cure for IPF, and most patients continue to progress despite treatment. As such, comprehensive care of patients with IPF, including management of concomitant conditions and physical debility, as well as timely referral for lung transplantation, remains essential. Several agents with a high potential are currently being tested, and many more are ready for clinical trials. Their completion is critical for achieving the ultimate goal of curing patients with IPF. PMID:25767391

  9. Prediction of Local Ultimate Strain and Toughness of Trabecular Bone Tissue by Raman Material Composition Analysis

    Directory of Open Access Journals (Sweden)

    Roberto Carretta


    Full Text Available Clinical studies indicate that bone mineral density correlates with fracture risk at the population level but does not correlate with individual fracture risk well. Current research aims to better understand the failure mechanism of bone and to identify key determinants of bone quality, thus improving fracture risk prediction. To get a better understanding of bone strength, it is important to analyze tissue-level properties not influenced by macro- or microarchitectural factors. The aim of this pilot study was to identify whether and to what extent material properties are correlated with mechanical properties at the tissue level. The influence of macro- or microarchitectural factors was excluded by testing individual trabeculae. Previously reported data of mechanical parameters measured in single trabeculae under tension and bending and its compositional properties measured by Raman spectroscopy was evaluated. Linear and multivariate regressions show that bone matrix quality but not quantity was significantly and independently correlated with the tissue-level ultimate strain and postyield work (r=0.65–0.94. Principal component analysis extracted three independent components explaining 86% of the total variance, representing elastic, yield, and ultimate components according to the included mechanical parameters. Some matrix parameters were both included in the ultimate component, indicating that the variation in ultimate strain and postyield work could be largely explained by Raman-derived compositional parameters.

  10. Molar mass of poly(ethylene terephthalate) (PET) during ultimate uniaxial drawing

    NARCIS (Netherlands)

    Göschel, U.; Cools, P.J.C.H.


    The changes of the average molar mass Mw, Mn, Mz, and molar mass distributions during multistep uniaxial drawing of poly(ethylene terephthalate) (PET) to achieve ultimate mechanical properties have been studied in detail by means of size exclusion chromatography (SEC) with triple detection:

  11. Molar-Mass of Poly(Ethylene-Terephthalate) (PET) During Ultimate Uniaxial Drawing

    NARCIS (Netherlands)

    Göschel, A.G.P.U.; Cools, P.J.C.H.


    The changes of the average molar mass Mw, Mn, Mz, and molar mass distributions during multistep uniaxial drawing of poly(ethylene terephthalate) (PET) to achieve ultimate mechanical properties have been studied in detail by means of size exclusion chromatography (SEC) with triple detection:

  12. Prisoner Fasting as Symbolic Speech: The Ultimate Speech-Action Test. (United States)

    Sneed, Don; Stonecipher, Harry W.

    The ultimate test of the speech-action dichotomy, as it relates to symbolic speech to be considered by the courts, may be the fasting of prison inmates who use hunger strikes to protest the conditions of their confinement or to make political statements. While hunger strikes have been utilized by prisoners for years as a means of protest, it was…

  13. Reliability analysis of production ships with emphasis on load combination and ultimate strength

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xiaozhi


    This thesis deals with ultimate strength and reliability analysis of offshore production ships, accounting for stochastic load combinations, using a typical North Sea production ship for reference. A review of methods for structural reliability analysis is presented. Probabilistic methods are established for the still water and vertical wave bending moments. Linear stress analysis of a midships transverse frame is carried out, four different finite element models are assessed. Upon verification of the general finite element code ABAQUS with a typical ship transverse girder example, for which test results are available, ultimate strength analysis of the reference transverse frame is made to obtain the ultimate load factors associated with the specified pressure loads in Det norske Veritas Classification rules for ships and rules for production vessels. Reliability analysis is performed to develop appropriate design criteria for the transverse structure. It is found that the transverse frame failure mode does not seem to contribute to the system collapse. Ultimate strength analysis of the longitudinally stiffened panels is performed, accounting for the combined biaxial and lateral loading. Reliability based design of the longitudinally stiffened bottom and deck panels is accomplished regarding the collapse mode under combined biaxial and lateral loads. 107 refs., 76 refs., 37 tabs.

  14. Magnetic surfaces, particle orbits and neutral injection in conventional and ultimate torsatrons

    International Nuclear Information System (INIS)

    Anderson, D.T.; Derr, J.A.; Kruckewitt, T.; Shohet, J.L.; Rehker, S.; Tataronis, J.A.


    Capabilities in fully non-axisymmetric numerical methods have resulted in a parametric study of various conventional and ultimate torsatron configurations. No superbananas are found in torsatrons without local magnetic wells. Neutral injection calculations show that, if the vacuum magnetic surfaces are well defined, tangential injection is very efficient

  15. Study of ultimate heat sink to Angra-1,2 and 3 Nuclear Power Plants

    International Nuclear Information System (INIS)

    Moreira, R.M.; Pinto, A.M.F.


    This report presents the premises, results and conclusion of study done to ultimate heat sink of Angra 1,2 and 3 units, with base in postulated accidents that generate transient heat discharges to environment. It's explicitily presumed the eventuality of discharging heat water recirculation. (C.M.) [pt

  16. Method for ultimate disposition of borate containing radioactive wastes by vitrification

    International Nuclear Information System (INIS)

    Bege, D.; Faust, H.J.; Puthawala, A.; Stunkel, H.


    Method for the ultimate disposition of radioactive wastes by vitrification, in which weak to medium radioactive waste concentrates from borate-containing radioactive liquids are mixed with added glass-forming materials, maximally in a ratio of 1:3, and the mixture heated to obtain a glass-forming melt

  17. 26 CFR 48.6427-10 - Kerosene; claims by registered ultimate vendors (blocked pumps). (United States)


    ... (blocked pumps). 48.6427-10 Section 48.6427-10 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE...; claims by registered ultimate vendors (blocked pumps). (a) Overview. This section provides rules under... allowed by section 6427(l)(5)(B)(i). These claims relate to kerosene sold from a blocked pump. Claims...

  18. Discussion of the Method to Determine the Ultimate Bearing Capacity of Soil Foundation (United States)

    Du, Peng; Liu, Xiaoling; Zhang, Yangfu


    Combining literature examples, this paper has carried out Contrastive analysis of the theoretical formula method and finite element method about the ultimate bearing capacity of foundation, To verify rationality and superiority of the incremental load method in finite element ABAQUS in solving the bearing capacity of foundation soil. The study can provide certain reference for practical engineering calculation and analysis of foundation bearing capacity.

  19. Too many journals? Towards a theory of repeated rejections and ultimate acceptance

    NARCIS (Netherlands)

    Oosterhaven, Jan

    Under a set of reasonable assumptions, it is shown that all manuscripts submitted to any journal will ultimately be published, either by the first journal or by one of the following journals to which a manuscript is resubmitted. This suggests that low quality manuscripts may also be published, which

  20. proximate and ultimate analysis of fuel pellets from oil palm residues

    African Journals Online (AJOL)


    Keywords: Oil Palm Residues, Fuel Pellets, Proximate Analysis, Ultimate Analysis. 1. INTRODUCTION ... Pelletizing of this biomass resources into pellets is a way of ensuring a ... demand for pellets [3], and alternative feed-stocks such as palm kernel ... agro-residues, selection of the best pellets has to be made based on ...

  1. 7 CFR 4280.29 - Supplemental financing required for the Ultimate Recipient Project. (United States)


    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Supplemental financing required for the Ultimate Recipient Project. 4280.29 Section 4280.29 Agriculture Regulations of the Department of Agriculture... AND GRANTS Rural Economic Development Loan and Grant Programs § 4280.29 Supplemental financing...

  2. Identification of unique expression signatures and therapeutic targets in esophageal squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Yan Wusheng


    Full Text Available Abstract Background Esophageal squamous cell carcinoma (ESCC, the predominant histological subtype of esophageal cancer, is characterized by high mortality. Previous work identified important mRNA expression differences between normal and tumor cells; however, to date there are limited ex vivo studies examining expression changes occurring during normal esophageal squamous cell differentiation versus those associated with tumorigenesis. In this study, we used a unique tissue microdissection strategy and microarrays to measure gene expression profiles associated with cell differentiation versus tumorigenesis in twelve cases of patient-matched normal basal squamous epithelial cells (NB, normal differentiated squamous epithelium (ND, and squamous cell cancer. Class comparison and pathway analysis were used to compare NB versus tumor in a search for unique therapeutic targets. Results As a first step towards this goal, gene expression profiles and pathways were evaluated. Overall, ND expression patterns were markedly different from NB and tumor; whereas, tumor and NB were more closely related. Tumor showed a general decrease in differentially expressed genes relative to NB as opposed to ND that exhibited the opposite trend. FSH and IgG networks were most highly dysregulated in normal differentiation and tumorigenesis, respectively. DNA repair pathways were generally elevated in NB and tumor relative to ND indicating involvement in both normal and pathological growth. PDGF signaling pathway and 12 individual genes unique to the tumor/NB comparison were identified as therapeutic targets, and 10 associated ESCC gene-drug pairs were identified. We further examined the protein expression level and the distribution patterns of four genes: ODC1, POSTN, ASPA and IGF2BP3. Ultimately, three genes (ODC1, POSTN, ASPA were verified to be dysregulated in the same pattern at both the mRNA and protein levels. Conclusions These data reveal insight into genes and

  3. Goals? What goals? Europeans to hear more about the world's millennium development goals

    International Nuclear Information System (INIS)

    Bianchi, S.


    The European Union (EU) is quickly becoming the front-runner of development aid to regions in Africa and other developing countries. However, over three-quarters of EU citizens are unaware of development efforts being made on the part of the Union to Third World countries, according to a public opinion poll released by Eurobarometer. In light of the low awareness of the EU's development agenda and the United Nations's Millennium Development Goals, the EU Humanitarian Aid and Development Commission has employed a campaign to raise the level of awareness among the EU's 460 million citizens

  4. Goal motives and multiple-goal striving in sport and academia: A person-centered investigation of goal motives and inter-goal relations. (United States)

    Healy, Laura C; Ntoumanis, Nikos; Duda, Joan L


    This investigation extended the goal striving literature by examining motives for two goals being pursued simultaneously. Grounded in self-determination theory, we examined how student-athletes' motives for their sporting and academic goals were associated with inter-goal facilitation and interference. Cross-sectional survey. UK university student-athletes (n=204) identified their most important sporting and academic goals. They then rated their extrinsic, introjected, identified and intrinsic motives for these goals and completed questionnaires assessing inter-goal facilitation and interference. Using a person-centered approach via latent profile analysis, we identified three distinct profiles of goal motives. Auxiliary analyses showed that the profile with high identified motives for both goals reported greater inter-goal facilitation. Extending the previous literature, the findings demonstrate the benefits of autonomous motives when simultaneously pursing goals in sport and academia. Copyright © 2016. Published by Elsevier Ltd.


    Directory of Open Access Journals (Sweden)

    Denys Yu. Lapigin


    Full Text Available Currently the tools to identify strategicallyimportant objectives of regional development is not enough to build a developmentperspective, relying on something special,what distinguishes each region from therest. The article discusses approaches to the formation of the regional developmentstrategy, which is based on goals set by the results of the analysis of the main factors inthe development of the region. The study is based on the methodology of systems theoryand methods of strategic management. The most important results should include tools tobuild the tree of strategic objectives resultingfrom the implementation of the algorithm forconstructing planes of analysis and development of the region. The results can be used to develop a strategy for the developmentof socio-economic systems of various typesand forms.

  6. The goal of ape pointing. (United States)

    Halina, Marta; Liebal, Katja; Tomasello, Michael


    Captive great apes regularly use pointing gestures in their interactions with humans. However, the precise function of this gesture is unknown. One possibility is that apes use pointing primarily to direct attention (as in "please look at that"); another is that they point mainly as an action request (such as "can you give that to me?"). We investigated these two possibilities here by examining how the looking behavior of recipients affects pointing in chimpanzees (Pan troglodytes) and bonobos (Pan paniscus). Upon pointing to food, subjects were faced with a recipient who either looked at the indicated object (successful-look) or failed to look at the indicated object (failed-look). We predicted that, if apes point primarily to direct attention, subjects would spend more time pointing in the failed-look condition because the goal of their gesture had not been met. Alternatively, we expected that, if apes point primarily to request an object, subjects would not differ in their pointing behavior between the successful-look and failed-look conditions because these conditions differed only in the looking behavior of the recipient. We found that subjects did differ in their pointing behavior across the successful-look and failed-look conditions, but contrary to our prediction subjects spent more time pointing in the successful-look condition. These results suggest that apes are sensitive to the attentional states of gestural recipients, but their adjustments are aimed at multiple goals. We also found a greater number of individuals with a strong right-hand than left-hand preference for pointing.

  7. Goal-setting in clinical medicine. (United States)

    Bradley, E H; Bogardus, S T; Tinetti, M E; Inouye, S K


    The process of setting goals for medical care in the context of chronic disease has received little attention in the medical literature, despite the importance of goal-setting in the achievement of desired outcomes. Using qualitative research methods, this paper develops a theory of goal-setting in the care of patients with dementia. The theory posits several propositions. First, goals are generated from embedded values but are distinct from values. Goals vary based on specific circumstances and alternatives whereas values are person-specific and relatively stable in the face of changing circumstances. Second, goals are hierarchical in nature, with complex mappings between general and specific goals. Third, there are a number of factors that modify the goal-setting process, by affecting the generation of goals from values or the translation of general goals to specific goals. Modifying factors related to individuals include their degree of risk-taking, perceived self-efficacy, and acceptance of the disease. Disease factors that modify the goal-setting process include the urgency and irreversibility of the medical condition. Pertinent characteristics of the patient-family-clinician interaction include the level of participation, control, and trust among patients, family members, and clinicians. The research suggests that the goal-setting process in clinical medicine is complex, and the potential for disagreements regarding goals substantial. The nature of the goal-setting process suggests that explicit discussion of goals for care may be necessary to promote effective patient-family-clinician communication and adequate care planning.

  8. Stress distribution difference between Lava Ultimate full crowns and IPS e.max CAD full crowns on a natural tooth and on tooth-shaped implant abutments. (United States)

    Krejci, Ivo; Daher, René


    The goal of this short communication is to present finite element analysis comparison of the stress distribution between CAD/CAM full crowns made of Lava Ultimate and of IPS e.max CAD, adhesively luted to natural teeth and to implant abutments with the shape of natural teeth. Six 3D models were prepared using a 3D content-creating software, based on a micro-CT scan of a human mandibular molar. The geometry of the full crown and of the abutment was the same for all models representing Lava Ultimate full crowns (L) and IPS e.max CAD full crowns (E) on three different abutments: prepared natural tooth (n), titanium abutment (t) and zirconia abutment (z). A static load of 400 N was applied on the vestibular and lingual cusps, and fixtures were applied to the base of the models. After running the static linear analysis, the post-processing data we analyzed. The stress values at the interface between the crown and the abutment of the Lt and Lz groups were significantly higher than the stress values at the same interface of all the other models. The high stress concentration in the adhesive at the interface between the crown and the abutment of the Lava Ultimate group on implants might be one of the factors contributing to the reported debondings of crowns.

  9. Therapeutic HIV Peptide Vaccine

    DEFF Research Database (Denmark)

    Fomsgaard, Anders


    Therapeutic vaccines aim to control chronic HIV infection and eliminate the need for lifelong antiretroviral therapy (ART). Therapeutic HIV vaccine is being pursued as part of a functional cure for HIV/AIDS. We have outlined a basic protocol for inducing new T cell immunity during chronic HIV-1...... infection directed to subdominant conserved HIV-1 epitopes restricted to frequent HLA supertypes. The rationale for selecting HIV peptides and adjuvants are provided. Peptide subunit vaccines are regarded as safe due to the simplicity, quality, purity, and low toxicity. The caveat is reduced immunogenicity...

  10. Illegitimacy Improves Goal Pursuit in Powerless Individuals


    Willis , Guillermo B.; Guinote , Ana; Rodríguez-Bailón , Rosa


    Abstract The effects of power legitimacy on self-regulation during goal pursuit were examined. Study 1 focused on goal-setting and goal-striving. Specifically, it examined how much time legitimate and illegitimate powerless individuals needed to set goals, and how many means they generated to pursue these goals. Study 2 examined persistence in the face of difficulties. Consistently across these studies illegitimacy improved self-regulation in powerless individuals. Illegitimate pow...

  11. Goal-based dictator game (United States)

    Zaibidi, Nerda Zura; Ibrahim, Adyda; Abidin, Norhaslinda Zainal


    A considerable number of studies have been conducted to study fairness issues using two-player game. Dictator Game is one of the two-player games that receive much attention. In this paper, we develop an evolutionary approach to the Dictator Game by using Goal programming to build a model of human decision-making for cooperation. The model is formulated based on the theories of cognitive neuroscience that is capable in capturing a more realistic fairness concerns between players in the games. We show that fairness will evolve by taking into account players' aspirations and preferences explicitly in terms of profit and fairness concerns. The model is then simulated to investigate any possible effective strategy for people in economics to deal with fairness coalition. Parallels are drawn between the approach and concepts of human decision making from the field of cognitive neuroscience and psychology. The proposed model is also able to help decision makers to plan or enhance the effective strategies for business purposes.

  12. Ultimate uniaxial compressive strength of stiffened panel with opening under lateral pressure

    Directory of Open Access Journals (Sweden)

    Chang-Li Yu


    Full Text Available This paper concentrated on the ultimate uniaxial compressive strength of stiffened panel with opening under lateral load and also studied the design-oriented formulae. For this purpose, three series of well executed experiments on longitudinal stiffened panel with rectangular opening subjected to the combined load have been selected as test models. The finite element analysis package, ABAQUS, is used for simulation with considering the large elasticplastic deflection behavior of stiffened panels. The feasibility of the numerical procedure is verified by a good agreement of experimental results and numerical results. More cases studies are executed employing nonlinear finite element method to analyze the influence of design variables on the ultimate strength of stiffened panel with opening under combined pressure. Based on data, two design formulae corresponding to different opening types are fitted, and accuracy of them is illustrated to demonstrate that they could be applied to basic design of practical engineering structure.

  13. The Assessment of the Ultimate Hull Girder Strength of RO-RO Ship after Damages (United States)

    Zubair Muis Alie, Muhammad; Sitepu, Ganding; Izaak Latumahin, Samuel


    Many accidents of Ro-Ro ships happen in Indonesia such as collision and grounding. When the collision or grounding takes place on the Ro-Ro ship, the ultimate strength of hull structure after damage becomes decrease. Car and passenger decks are critical location since collision and/or grounding occur. In the present study, the assessment of the ultimate hull girder strength is conducted. The cross section of Ro-Ro ship is taken to be analyzed. The collision and grounding damages are assumed to be palced on the side and bottom area, respectively. The damages are created by removing the element from the side shell and bottom part. Finally, the result obtained is compared with one another.

  14. Accelerator physics and technology limitations to ultimate energy and luminosity in very large hadron colliders

    Energy Technology Data Exchange (ETDEWEB)

    P. Bauer et al.


    The following presents a study of the accelerator physics and technology limitations to ultimate energy and luminosity in very large hadron colliders (VLHCs). The main accelerator physics limitations to ultimate energy and luminosity in future energy frontier hadron colliders are synchrotron radiation (SR) power, proton-collision debris power in the interaction regions (IR), number of events-per-crossing, stored energy per beam and beam-stability [1]. Quantitative estimates of these limits were made and translated into scaling laws that could be inscribed into the particle energy versus machine size plane to delimit the boundaries for possible VLHCs. Eventually, accelerator simulations were performed to obtain the maximum achievable luminosities within these boundaries. Although this study aimed at investigating a general VLHC, it was unavoidable to refer in some instances to the recently studied, [2], 200 TeV center-of-mass energy VLHC stage-2 design (VLHC-2). A more thorough rendering of this work can be found in [3].

  15. Ultimate Limit State Model Basis for Assessment of Offshore Wind Energy Converters

    DEFF Research Database (Denmark)

    Thöns, Sebastian; Faber, M. H.; Rücker, W.


    then in combina-tion with the ultimate limit state requirements leads to the specific constitutive relations. As a result finite element models based on shell elements incorporating a structural and a loading model are introduced and described in detail. Applying these models the ultimate capacity of the support...... on the basis of literature review and measurement data from a prototype Multibrid M5000 support structure. In combination with the developed structural and loading models, sensitivity analyses in regard to the responses are peiformed to enhance the understanding and to refine the developed models. To this end...... variables on the responses including nonlinearity the refinement of the model is performed on a quantitative basis....

  16. Evaluation of time-accelerated irradiation method of elastomer by modulus-ultimate elongation profile

    International Nuclear Information System (INIS)

    Ito, Masayuki; Oka, Toshitaka; Hama, Yosimasa


    'Generalized modulus-ultimate elongation profile' was induced from the relationship between the modulus and the ultimate elongation of an elastomer that was quantitatively added crosslinking and scission. This profile can be used to evaluate the time-accelerated irradiation methods of ethylene-propylene-diene elastomer. The irradiation under low dose rate (0.33 kGy/h) at room temperature was the reference condition. The short-time irradiation condition was 4.2 kGy/h in 0.5 MPa oxygen at room temperature and 5.0 kGy/h in air at 70 o C. The former tended to bring about the higher ratio of scission than the reference condition; the latter tended to bring about the higher ratio of crosslinking.

  17. Out-of-plane ultimate shear strength of RC mat-slab foundations

    International Nuclear Information System (INIS)

    Kumagai, Hitoshi; Nukui, Yasushi; Imamura, Akira; Terayama, Takeshi; Hagiwara, Tetsuya; Kojima, Isao


    There have been few studies on the out-of-plane shear in RC mat-slab foundations, and the reasonable method has been demanded to estimate ultimate shear strength of RC mat-slab foundations in the nuclear facilities. In the previous study, the out-of-plane loading tests on the 20 square slab specimens had been performed to collect the fundamental data. In this study, the test results were successfully predicted by 3D non-linear Finite Element Analysis. It has been confirmed that the ultimate shear stress in the slab specimen can be estimated by the Arakawa's formula, which is commonly used to estimate the shear strength of RC beams. (author)

  18. Ultimate analysis of PWR prestressed concrete containment subjected to internal pressure

    International Nuclear Information System (INIS)

    Hu, H.-T.; Lin, Y.-H.


    Numerical analyses are carried out by using the ABAQUS finite element program to predict the ultimate pressure capacity and the failure mode of the PWR prestressed concrete containment at Maanshan nuclear power plant. Material nonlinearity such as concrete cracking, tension stiffening, shear retention, concrete plasticity, yielding of prestressing tendon, yielding of steel reinforcing bar and degradation of material properties due to high temperature are all simulated with proper constitutive models. Geometric nonlinearity due to finite deformation has also been considered. The results of the analysis show that when the prestressed concrete containment fails, extensive cracks take place at the apex of the dome, the junction of the dome and cylinder, and the bottom of the cylinder connecting to the base slab. In addition, the ultimate pressure capacity of the containment is higher than the design pressure by 86%

  19. Nonlinear finite element analysis of nuclear reinforced prestressed concrete containments up to ultimate load capacity

    International Nuclear Information System (INIS)

    Gupta, A.; Singh, R.K.; Kushwaha, H.S.; Mahajan, S.C.; Kakodkar, A.


    For safety evaluation of nuclear structures a finite element code ULCA (Ultimate Load Capacity Assessment) has been developed. Eight/nine noded isoparametric quadrilateral plate/shell element with reinforcement as a through thickness discrete but integral smeared layer of the element is presented to analyze reinforced and prestressed concrete structures. Various constitutive models such as crushing, cracking in tension, tension stiffening and rebar yielding are studied and effect of these parameters on the reserve strength of structures is brought out through a number of benchmark tests. A global model is used to analyze the prestressed concrete containment wall of a typical 220 MWe Pressurized Heavy Water Reactor (PHWR) up to its ultimate capacity. This demonstrates the adequacy of Indian PHWR containment design to withstand severe accident loads

  20. A Holistic Quality Evaluation, Selection and Improvement Approach driven by Multilevel Goals and Strategies

    Directory of Open Access Journals (Sweden)

    Belen Rivera


    Full Text Available Organizations should establish business goals and check for their achievement in a systematic and disciplined way. In order to know if a business goal is achieved, it should be necessary to consider information need goals that also can require satisfying measurement and evaluation goals at operational level. Furthermore, if measurement and evaluation goals are not aligned with top-level business goals such as tactical or strategic level goals, the organization could waste its effort and resources. Usually, the different goals established in an organization are operationalized through projects. For a given project, strategies should be used in order to help in the goal achievement. A strategy defines a set of activities and methods to be followed for a specific goal purpose. Ultimately, to engineering all these issues in a systematic way, organizations should adopt a holistic evaluation approach supported by a set of integrated strategies. By means of a systematic literature review as research method, we have observed that very few approaches support integrated strategies and multilevel goals. To bridge this gap, we have developed a holistic quality multilevel and multipurpose evaluation approach that ties together multilevel goals, projects and integrated strategies. As contributions, this paper discusses an enhanced conceptual base (specified by ontologies for linking business and information need goal concepts with project, strategy and nonfunctional requirements concepts. Then, it defines the step by step of our holistic quality evaluation approach, by listing the necessary activities to establish goals and projects at different organizational levels. Lastly, it specifies and illustrates evaluation scenarios for business/information need goal purposes such as understanding, improving, monitoring and controlling, comparing and selecting entities, which are supported by strategies and strategy patterns.

  1. Qualtum cosmics-and-chaotics--the ultimate tortoise in physics and modern medicine.

    Directory of Open Access Journals (Sweden)

    Kothari M


    Full Text Available Qualtum cosmics is the qualitative opposite of quantum mechanics. The flip-side of qualtum cosmics is qualtum chaotics, the two governing much of what is seen as inscrutable in medicine. The Ultimate (Last Tortoise is close to Einsteinean idea of a Unified Theory, a single concept that can explain whatsoever there is in physics, (and in medicine, or what have you.

  2. Utilization of metal scrap for the production of waste drums for ultimate disposal

    International Nuclear Information System (INIS)

    Janberg, K.; Rittscher, D.


    The contribution reviews the history of development of the techniques for treatment of decommissioning scrap from the beginning of the 1980's onwards (decommissioning of the Niederaichbach and Gundremmingen nuclear power stations), together with the radiological measuring methods required for regulatory purposes. The advantages of the recycling of the metal scrap by means of melting, and of materials utilization for production of waste containers for ultimate storage are discussed together with product quality assurance criteria. (RB) [de

  3. The Influence of Wagon Structure Part Shape Optimization on Ultimate Fatigue Strength


    Milovanović, Vladimir; Živković, Miroslav; Jovičić, Gordana; Živković, Jelena; Kozak, Dražan


    This study investigates how shape optimisation affects the ultimate fatigue strength of a mechanical part. The mechanical part chosen for this investigation is an axle guard of running gear elements of the Hccrrs 2x2 axle car-carrying wagon. The static and fatigue strength analysis procedure according to the UIC 517 standard and numerical methods have been applied. Material properties were determined experimentally and the necessary numerical calculations were performed by using the finite el...

  4. The ultimate safe (US) Reactor: A concept for the third millenium

    International Nuclear Information System (INIS)

    Gat, U.


    The Ultimate Safe (U.S.) Reactor is based on a novel safety concept. Fission products in the reactor are allowed to accumulate only to a level at which they would constitute a harmless source term. Removal of fission products also removes the decay heat - the driving force for the source term. The reactor has no excess criticality and is controlled by the reactivity temperature coefficient. Safety is inherent and passive. Waste is removed from the site promptly

  5. Modeling and simulation of loss of the ultimate heat sink in a typical material testing reactor

    International Nuclear Information System (INIS)

    El-Khatib, Hisham; El-Morshedy, Salah El-Din; Higazy, Maher G.; El-Shazly, Karam


    Highlights: ► A thermal–hydraulic model has been developed to simulate loss of the ultimate heat sink in MTR. ► The model involves three coupled sub-models for core, heat exchanger and cooling tower. ► The model is validated against PARET for steady-state and verified by operation data for transients. ► The model is used to simulate the behavior of the reactor under a loss of the ultimate heat sink. ► The model results are analyzed and discussed. -- Abstract: A thermal–hydraulic model has been developed to simulate loss of the ultimate heat sink in a typical material testing reactor (MTR). The model involves three interactively coupled sub-models for reactor core, heat exchanger and cooling tower. The model is validated against PARET code for steady-state operation and verified by the reactor operation records for transients. Then, the model is used to simulate the thermal–hydraulic behavior of the reactor under a loss of the ultimate heat sink event. The simulation is performed for two operation regimes: regime I representing 11 MW power and three cooling tower cells operated, and regime II representing 22 MW power and six cooling tower cells operated. In regime I, the simulation is performed for 1, 2 and 3 cooling tower cells failed while in regime II, it is performed for 1, 2, 3, 4, 5 and 6 cooling tower cells failed. The simulation is performed under protected conditions where the safety action called power reduction is triggered by reactor protection system to decrease the reactor power by 20% when the coolant inlet temperature to the core reaches 43 °C and scram is triggered if the core inlet temperature reaches 44 °C. The model results are analyzed and discussed.

  6. Tasks of radiation protection in the centralized collection and ultimate disposal of radioactive waste

    International Nuclear Information System (INIS)

    Boerst, F.M.; Fasten, C.; Koerner, W.; Oppermann, U.; Werner, H.J.; Zappe, D.


    In the GDR, the ERAM (Endlager fuer radioaktive Abfaelle, Morsleben), an operating unit of Volkseigenes Kombinat Kernkraftwerke 'Bruno Leuschner' in Greifswald, is responsible for the central collection and ultimate disposal of radioactive waste. From the licensing body's point of view an assessment is given of the legislation for radioactive wastes, especially as to their collection, transport to and handling in the final repository. As a result, some conclusions are drawn concerning future work in this field. 9 tabs., 34 refs. (author)

  7. Effects of urbanization on animal behaviour : patterns, underlying mechanisms and ultimate causes


    Miranda, Ana Catarina Sequeira Nunes Coutinho de


    Human-altered environmental conditions affect many species at the global scale. An extreme form of anthropogenic alteration is the existence and rapid increase of urban areas. A key question is how animals cope with urbanization. In order to live in cities, animals have to adjust their behaviour and life histories to the urban novel environment.The main objectives of this thesis were to investigate (i) the existence of behavioural changes related to the urbanization process, (ii) the ultimate...

  8. Dual characteristics of yield and ultimate strength as applied to two grades of beryllium

    International Nuclear Information System (INIS)

    Priddy, T.G.; Benzley, S.E.; Johnson, R.L.


    Published yield and ultimate biaxial strength data for two grades of beryllium are correlated with the use of a macroscopic failure model. Cross sections of the resulting surfaces in three-dimensional stress space are drawn to illustrate the expected transition from ductile to brittle fracture for triaxial tension states of stress. The usefulness of these models to the prediction of fracture in ductile materials is discussed. 5 tables, 8 figures, 11 references

  9. Marketing therapeutic recreation services. (United States)

    Thorn, B E


    The use of marketing strategies can enhance the delivery of therapeutic recreation services. This article discusses how agencies can adapt marketing techniques and use them to identify potential markets, improve image, evaluate external pressures, and maximize internal strengths. Four variables that can be controlled and manipulated in a proposed marketing plan are product, price, place and promotion.

  10. Therapeutic Recombinant Monoclonal Antibodies (United States)

    Bakhtiar, Ray


    During the last two decades, the rapid growth of biotechnology-derived techniques has led to a myriad of therapeutic recombinant monoclonal antibodies with significant clinical benefits. Recombinant monoclonal antibodies can be obtained from a number of natural sources such as animal cell cultures using recombinant DNA engineering. In contrast to…

  11. Therapeutic applications of radiopharmaceuticals

    International Nuclear Information System (INIS)

    Baker, W.J.; Datz, F.L.; Beightol, R.W.


    Whether a radiopharmaceutical has diagnostic or therapeutic application depends on both the isotope and pharmaceutical used. For diagnostic applications, the isotope should undergo only γ-decay, since usually only γ-radiation is detected by nuclear medicine cameras. The half-life should be just long enough to allow the procedure to be performed. In contrast, the isotope needed for therapeutic purposes should have particulate radiation, such as a β-particle (electron), since these are locally absorbed an increase the local radiation dose. γ-Radiation, which penetrates the tissues, produces less radiation dose than do Β-particles. Several references dealing with radioactive decay, particulate interactions, and diagnostic and therapeutic applications of radiopharmaceuticals are available. Radiopharmaceuticals can legally be used only by physicians who are qualified by specific training in the safe handling of radionuclides. The experience and training of these physicians must be approved by the Nuclear Regulatory Commission or Agreement State Agency authorized to license the use of radiopharmaceuticals. A list of all byproduct material and procedures is available in the Code of Federal Regulations. Of the many radiopharmaceuticals available for diagnostic and therapeutic use, only those commonly used are discussed in this chapter

  12. Numerical Study on Ultimate Behaviour of Bolted End-Plate Steel Connections

    Directory of Open Access Journals (Sweden)

    R.E.S. Ismail

    Full Text Available Abstract Bolted end-plate steel connections have become more popular due to ease of fabrication. This paper presents a three dimension Finite Element Model (FEM, using the multi-purpose software ABAQUS, to study the effect of different geometrical parameters on the ultimate behavior of the connection. The proposed model takes into account material and geometrical non-linearities, initial imperfection, contact between adjacent surfaces and the pretension force in the bolts. The Finite Element results are calibrated with published experimental results ''briefly reviewed in this paper'' and verified that the numerical model can simulate and analyze the overall and detailed behavior of different types of bolted end-plate steel connections. Using verified FEM, parametric study is then carried out to study the ultimate behavior with variations in: bolt diameter, end-plate thickness, length of column stiffener, angle of rib stiffener. The results are examined with respect to the failure modes, the evolution of the resistance, the initial stiffness, and the rotation capacity. Finally, the ultimate behavior of the bolted end-plate steel connection is discussed in detail, and recommendations for the design purpose are made.

  13. Methodology for predicting ultimate pressure capacity of the ACR-1000 containment structure

    International Nuclear Information System (INIS)

    Saudy, A.M.; Awad, A.; Elgohary, M.


    The Advanced CANDU Reactor or the ACR-1000 is developed by Atomic Energy of Canada Limited (AECL) to be the next step in the evolution of the CANDU product line. It is based on the proven CANDU technology and incorporates advanced design technologies. The ACR containment structure is an essential element of the overall defense in depth approach to reactor safety, and is a physical barrier against the release of radioactive material to the environment. Therefore, it is important to provide a robust design with an adequate margin of safety. One of the key design requirements of the ACR containment structure is to have an ultimate pressure capacity that is at least twice the design pressure Using standard design codes, the containment structure is expected to behave elastically at least up to 1.5 times the design pressure. Beyond this pressure level, the concrete containment structure with reinforcements and post-tension tendons behaves in a highly non-linear manner and exhibits a complex response when cracks initiate and propagate. To predict the structural non-linear responses, at least two critical features are involved. These are: the structural idealization by the geometry and material property models, and the adopted solution algorithm. Therefore, detailed idealization of the concrete structure is needed in order to accurately predict its ultimate pressure capacity. This paper summarizes the analysis methodology to be carried out to establish the ultimate pressure capacity of the ACR containment structure and to confirm that the structure meets the specified design requirements. (author)

  14. Transition to the Ultimate Regime in Two-Dimensional Rayleigh-Bénard Convection (United States)

    Zhu, Xiaojue; Mathai, Varghese; Stevens, Richard J. A. M.; Verzicco, Roberto; Lohse, Detlef


    The possible transition to the so-called ultimate regime, wherein both the bulk and the boundary layers are turbulent, has been an outstanding issue in thermal convection, since the seminal work by Kraichnan [Phys. Fluids 5, 1374 (1962), 10.1063/1.1706533]. Yet, when this transition takes place and how the local flow induces it is not fully understood. Here, by performing two-dimensional simulations of Rayleigh-Bénard turbulence covering six decades in Rayleigh number Ra up to 1 014 for Prandtl number Pr =1 , for the first time in numerical simulations we find the transition to the ultimate regime, namely, at Ra*=1013 . We reveal how the emission of thermal plumes enhances the global heat transport, leading to a steeper increase of the Nusselt number than the classical Malkus scaling Nu ˜Ra1 /3 [Proc. R. Soc. A 225, 196 (1954), 10.1098/rspa.1954.0197]. Beyond the transition, the mean velocity profiles are logarithmic throughout, indicating turbulent boundary layers. In contrast, the temperature profiles are only locally logarithmic, namely, within the regions where plumes are emitted, and where the local Nusselt number has an effective scaling Nu ˜Ra0.38 , corresponding to the effective scaling in the ultimate regime.

  15. Ultimate strength analysis of ring-stiffened cylinders subjected to hydrostatic pressure

    International Nuclear Information System (INIS)

    Park, Chi Mo


    In this study, ultimate strength analysis of ring-stiffened cylinders have been performed, considering the elasto-plastic large deflection. In the elasto-plastic analysis, von Mises yield criteria, the plastic flow theory and the layered approach have been adopted. In order to take into account the follower force effect of the hydrostatic pressure, the incremental load components have been updated at every loading step. As collapse modes, axisymmetric yielding, interframe shell buckling and general buckling are considered, while local buckling of ring-stiffener is not considered. Initial shape imperfection is assumed to be the elastic buckling mode to obtain the lower bound of the ultimate strength. Results of numerical analysis are compared with the experimental results to show the validity of the present approach. It has been drawn that the present numerical results are closely correlated with the experimental results. On the other hand, the effects of initial shape imperfection and condition on the ultimate strength have been investigated. (Author)

  16. Ultimate load design and testing of a cylindrical prestressed concrete vessel

    International Nuclear Information System (INIS)

    Stefanou, G.D.


    The object of this research was to design, construct and test to failure a prestressed concrete pressure vessel model that could be used to investigate the behavior of a full scale structure underworking and ultimate load. The properties and the design of the model was based generally on full scale vessels already constructed to house the nuclear reactors used in atomic power stations. To design the model the ultimate load approach was adopted throughout. All load factors associated with the prestressing have been defined and kept to a minimum in order that the vessel's behavior may be predicted. The tests on the vessel were carried out first on the elastic range to observe its behavior at working load and then at the ultimate range to observe the modes of failure and compare the actual results in both cases with the predicted values. Although full agreement between observed results and predicted values was not obtained, the conclusions drawn from the study were useful for the design of full scale vessels. (author)

  17. Goal conflicts, attainment of new goals, and well-being among managers. (United States)

    Kehr, Hugo M


    Researchers widely understand that conflicts among goals inhibit the attainment of these goals. However, this notion comes close to tautological reasoning. To avert this problem, this study examined whether preexisting goal conflict also inhibits success in newly set goals. Using the context of management training, in which managers collectively set new goals, the study variables were assessed at 3 testing periods covering 5 months. Results indicate that goal conflicts that persevere over time were associated with inhibited attainment of new goals but not with decreased subjective well-being (SWB). Goal attainment, however, was positively related to SWB. Interactions of residual changes in goal conflict and goal attainment were associated with positive affect.

  18. Scientific goals of SCHOOLS & QUAKES (United States)

    Brückl, Ewald; Köberl, Christian; Lenhardt, Wolfgang; Mertl, Stefan; Rafeiner-Magor, Walter; Stark, Angelika; Stickler, Gerald; Weber, Robert


    In many countries around the world seismometers are used in schools to broaden the knowledge in seismology in a vivid way and to take part in the observation of the current worldwide seismic activity. SCHOOLS & QUAKES is a project within the Sparkling Science program (, which not only pursues the given educational goals but also integrates scholars in seismological research permitting their own contributions. Research within SCHOOLS & QUAKES concentrates on the seismic activity of the Mürz Valley - Semmering - Vienna Basin transfer fault system in Austria because of its relatively high earthquake hazard and risk. The detection of low magnitude local earthquakes (magnitude ≤ 2), precise location of hypocenters, determination of the focal mechanisms, and correlation of hypocenters with active geological structures are the main scientific goals in this project. Furthermore, the long term build-up of tectonic stress, slip deficit and aseismic slip, and the maximum credible earthquake in this area are issues to be addressed. The scientific efforts of SCHOOLS & QUAKES build on the work of the Seismological Service of Austria at the Zentralanstalt für Meteorologie und Geodynamik (ZAMG), and benefit from the findings on the lithospheric structure of the Eastern Alps gained by the CELEBRATION 2000 and ALP 2002 projects. Regional Vp and Vs-models were derived from this data covering the SCHOOLS & QUAKES target area. Within the ALPAACT project (Seismological and geodetic monitoring of ALpine-PAnnonian ACtive Tectonics) the seismic network of the target area was densified by 7 broadband und 2 short period stations. Relocations based on a 3D-velocity model and the densified seismic network yielded substantially higher spatial resolution of seismically active structures. A new method based on waveform stacking (GRA, 16, EGU2014-5722) allowed for focal mechanism solutions of low magnitude (Ml ~2.5) events. Data from 22 GNSS stations have been

  19. Pro-Social Goals in Achievement Situations: Amity Goal Orientation Enhances the Positive Effects of Mastery Goal Orientation. (United States)

    Levontin, Liat; Bardi, Anat


    Research has neglected the utility of pro-social goals within achievement situations. In this article, four studies demonstrate that amity goal orientation, promoting mutual success of oneself together with others, enhances the utility of mastery goal orientation. We demonstrate this in longitudinally predicting performance (Studies 1 and 2) and in maintaining motivation after a disappointing performance (Studies 3 and 4). The studies demonstrate the same interaction effect in academic and in work achievement contexts. Specifically, whereas amity goal orientation did not predict achievement on its own, it enhanced the positive effect of mastery goal orientation. Together, these studies establish the importance of amity goal orientation while also advancing our understanding of the effects of other achievement goal orientations. We suggest future directions in examining the utility of amity goals in other contexts.

  20. Get a taste of your goals: promoting motive-goal congruence through affect-focus goal fantasy. (United States)

    Job, Veronika; Brandstätter, Veronika


    Studies show that motive-goal congruence is an important predictor of well-being (Baumann, Kaschel, & Kuhl, 2005; Brunstein, Schultheiss, & Grässmann, 1998). However, little is known about the factors that promote congruence between implicit motives and goals. Relying on McClelland's (1985) concept of implicit motives and the theory of fantasy realization (Oettingen, 1999), we postulated that goal fantasies focusing on motive-specific affective incentives promote motive-congruent goal setting. This hypothesis was tested in 3 experimental studies. In Study 1 (n=46) and Study 2 (n=48), participants were asked to select goals in a hypothetical scenario. In Study 3 (n=179), they rated their commitment to personal goals for their actual life situation. The results of all 3 studies supported our hypothesis that participants who focus on motive-specific affective incentives in their goal fantasies set their goals in line with their corresponding implicit motive dispositions.

  1. Comparative study of goal contents and goal characteristics between medical and business students. (United States)

    Park, Soowon; Kim, Ji Eun; Lee, Jun-Young; Shin, Jongho


    Medical and business are one of the most popular majors among students, and both fields require intensive training to reach certain level of expertise. During the development of professionalism, goal can become a crucial role in psychological impetus. The purpose of this study is to compare goal contents, goal characteristics, and effect of goal characteristics on student's major satisfaction between medical and business. A total of 193 undergraduate students (97 medical students, 96 business students) answered survey questions including goal contents, goal characteristics (goal autonomy, goal attainability, social value of goal) and satisfaction on their majors. Qualitative analysis of goal contents and quantitative analysis of goal characteristics, and their effects on student major satisfaction were performed. Goal content analysis showed percentage of social concern goal was higher in medical students (25.8%) than business students (6.3%), whereas percentage of wealth goal was higher business students (24.0%) than medical students (3.1%). Among goal characteristics, goal attainability and social value of goal were higher in medical students than business students. In both groups, social value of goal was significantly predict major satisfaction. Goal contents and goal characteristics are different between medical and business students. Curriculum and educational interventions that concerning students' goal and developing programs to enhance students' social value of goal is necessary.

  2. Self-regulation through Goal Setting

    DEFF Research Database (Denmark)

    Koch, Alexander; Nafziger, Julia


    Goals are an important motivator. But little is known about why and how people set them. We address this issue in a model based on two stylized facts. i) Goals serve as reference points for performance. ii) Present-biased preferences create self-control problems. We show the power and limits...... of self-regulation through goals. Goals increase an individual's motivation - but only up to a certain point. And they are painful self-disciplining devices. Greater self-control problems may result in tougher goals; but for a severe present bias goals either lack motivating force, or are too painful...

  3. Therapeutic neuroprotective agents for amyotrophic lateral sclerosis (United States)

    Pandya, Rachna S.; Zhu, Haining; Li, Wei; Bowser, Robert; Friedlander, Robert M.


    Amyotrophic lateral sclerosis (ALS) is a fatal chronic neurodegenerative disease whose hallmark is proteinaceous, ubiquitinated, cytoplasmic inclusions in motor neurons and surrounding cells. Multiple mechanisms proposed as responsible for ALS pathogenesis include dysfunction of protein degradation, glutamate excitotoxicity, mitochondrial dysfunction, apoptosis, oxidative stress, and inflammation. It is therefore essential to gain a better understanding of the underlying disease etiology and search for neuroprotective agents that might delay disease onset, slow progression, prolong survival, and ultimately reduce the burden of disease. Because riluzole, the only Food and Drug Administration (FDA)-approved treatment, prolongs the ALS patient’s life by only 3 months, new therapeutic agents are urgently needed. In this review, we focus on studies of various small pharmacological compounds targeting the proposed pathogenic mechanisms of ALS and discuss their impact on disease progression. PMID:23864030

  4. Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals

    DEFF Research Database (Denmark)

    Campbell, Meghan A; Wengel, Jesper


    Oligonucleotide chemistry has been developed greatly over the past three decades, with many advances in increasing nuclease resistance, enhancing duplex stability and assisting with cellular uptake. Locked nucleic acid (LNA) is a structurally rigid modification that increases the binding affinity...... of a modified-oligonucleotide. In contrast, unlocked nucleic acid (UNA) is a highly flexible modification, which can be used to modulate duplex characteristics. In this tutorial review, we will compare the synthetic routes to both of these modifications, contrast the structural features, examine...... the hybridization properties of LNA and UNA modified duplexes, and discuss how they have been applied within biotechnology and drug research. LNA has found widespread use in antisense oligonucleotide technology, where it can stabilize interactions with target RNA and protect from cellular nucleases. The newly...

  5. Are therapeutic LDL goals justified? Controversies between the European and American guidelines

    Directory of Open Access Journals (Sweden)

    Vicente Bertomeu-Martínez


    Full Text Available Resumen La dislipemia es uno de los factores de riesgo más importantes de las enfermedades cardiovasculares, por lo que su tratamiento es una de las estrategias claves de la prevención cardiovascular. Las estatinas se han consolidado como el tratamiento de referencia para la reducción de los niveles séricos de colesterol. Existen algunas divergencias entre las guías americana y europea en el tratamiento de la dislipemia. En esta revisión narrativa se discuten los puntos clave de esta controversia.

  6. The Relation Between Goals and Autobiographical Memory

    DEFF Research Database (Denmark)

    Johannessen, Kim Berg; Rasmussen, Anne Scharling; Berntsen, Dorthe

    facilitate recall of goal congruent autobiographical memories which supports the idea of autobiographical memory facilitating goal attainment. Further, no differences between involuntary and voluntary memories with regard to frequency or characteristics of goal related content were found. Yet memories...... related to goals were rated as more central to the person's identity, life story and expectations for the future than non-goal related memories, irrespective of mode of recall. Interestingly, depression and PTSD symptoms correlated positively with the proportion of goal related memories, thereby......The present study examines involuntary (spontaneously retrieved) versus voluntary (deliberately retrieved) autobiographical memories in relation to earlier registered goals measured by the Personal Concern Inventory (Cox & Klinger, 2000). We found that the important and not yet planned goals...

  7. Growth goals, maturity, and well-being. (United States)

    Bauer, Jack J; McAdams, Dan P


    In 2 studies (125 college students and 51 adults), 2 forms of growth goals (exploratory and intrinsic) were compared with 2 forms of personality development (social-cognitive maturity and social-emotional well-being). Participants whose narratives of major life goals emphasized conceptual exploration were especially likely to have high levels of maturity (measured as ego development; J. Loevinger, 1976), whereas those whose goals emphasized intrinsic interests (K. M. Sheldon & T. Kasser, 1995) were especially likely to have high levels of well-being. Participants who had coherent hierarchies of growth goals on the levels of major life goals and everyday goals were especially likely to have high levels of personality development. Finally, growth goals accounted for some relationships between age and personality development. Growth goals are discussed in terms of intentional self-development and specific developmental paths. (c) 2003 APA

  8. Goal setting: Eating, Physical activity & Weight loss (United States)

    No matter what your weight loss goal is, the key to reaching your goals is to make changes to your lifestyle behaviors like eating and physical activity. This involves setting realistic expectations and making a plan.

  9. Goals, ways and the roots of our economic crisis

    Directory of Open Access Journals (Sweden)

    Bob Goudzwaard


    Full Text Available This article deals with the question if and how far religious points of view and messages of churches involved matter in the analysis of the roots of the present global economic crisis, and even more in the discussion about how to overcome the crisis itself. Economic experts such as Stiglitz point to the presence of factors such as greed, fear and utmost selfish behaviour. It inevitably leads to the ethical, but in fact also the religious question of how far people, especially economic agents, can go in the pursuit of their own economic interests without doing harm to others. Jesus asked his disciples to follow him: with Bonhoeffer, we could call that a Way-orientation. Where and how far can a conflict therefore arise between human goal-orientations, on the one hand, and a biblical Way-orientation, on the other hand? And is it indeed relevant when considering our present economic crisis? This article defends the last position, describing some categories (such as the choice of ultimate meaning, the sacro-sanctity of chosen instruments, and the demonisation of opponents which indicate that the borderline has been passed between responsible and irresponsible goal-orientations. The glorification of greed and the delegation of ultimate power to financial markets indicate that at this moment elements of idolatry (or the obedience to Mammon are at hand. They are also aggravating the present economic crisis. This implies that returning to the choice for decisive normative Way-orientations in economic life is possibly the only true way out of the present economic crisis.

  10. Stability and Change in Social Goals as Related to Goal Structures and Engagement in School (United States)

    Madjar, Nir


    The current studies explored (a) the extended external validity of social-goal-orientation framework; (b) the mediating role of social goals between classroom goal structures and students' engagement; and (c) whether changes in social goals can be explained by classroom goal structures and engagement. Study 1 was cross-sectional (N = 317), and…

  11. 15 CFR Supplement No. 3 to Part 748 - BIS-711, Statement by Ultimate Consignee and Purchaser Instructions (United States)


    ...” include: contractual, franchise, distributor, wholesaler, continuing and regular individual business, etc... persons, other than employees of the ultimate consignee or purchaser, who assisted in the preparation of...

  12. The actual goals of geoethics (United States)

    Nemec, Vaclav


    The most actual goals of geoethics have been formulated as results of the International Conference on Geoethics (October 2013) held at the geoethics birth-place Pribram (Czech Republic): In the sphere of education and public enlightenment an appropriate needed minimum know how of Earth sciences should be intensively promoted together with cultivating ethical way of thinking and acting for the sustainable well-being of the society. The actual activities of the Intergovernmental Panel of Climate Changes are not sustainable with the existing knowledge of the Earth sciences (as presented in the results of the 33rd and 34th International Geological Congresses). This knowledge should be incorporated into any further work of the IPCC. In the sphere of legislation in a large international co-operation following steps are needed: - to re-formulate the term of a "false alarm" and its legal consequences, - to demand very consequently the needed evaluation of existing risks, - to solve problems of rights of individuals and minorities in cases of the optimum use of mineral resources and of the optimum protection of the local population against emergency dangers and disasters; common good (well-being) must be considered as the priority when solving ethical dilemmas. The precaution principle should be applied in any decision making process. Earth scientists presenting their expert opinions are not exempted from civil, administrative or even criminal liabilities. Details must be established by national law and jurisprudence. The well known case of the L'Aquila earthquake (2009) should serve as a serious warning because of the proven misuse of geoethics for protecting top Italian seismologists responsible and sentenced for their inadequate superficial behaviour causing lot of human victims. Another recent scandal with the Himalayan fossil fraud will be also documented. A support is needed for any effort to analyze and to disclose the problems of the deformation of the contemporary


    Directory of Open Access Journals (Sweden)

    C. M. C. Falcão


    Full Text Available Pythiosis, a disease caused by the oomycete Pythium insidiosum, often presents inefficient response to chemotherapy. It is a consensus that, in spite the several therapeutic protocols, a combination of surgery, chemotherapy and immunotherapy should be used. Surgical excision requires the removal of the entire affected area, with a wide margin of safety. The use of antifungal drugs has resulted in variable results, both in vitro and in vivo, and presents low therapeutic efficiency due to differences in the agent characteristics, which differ from true fungi. Immunotherapy is a non-invasive alternative for the treatment of pythiosis, which aims at modifying the immune response of the host, thereby producing an effective response to the agent. Photodynamic therapy has emerged as a promising technique, with good activity against P. insidiosum in vitro and in vivo. However, more studies are necessary to increase the efficiency of the current treatment protocols and consequently improve the cure rates. This paper aims to conduct a review covering the conventional and recent therapeutic methods against P. insidiosum infections

  14. National Education Goals: Can We Afford Them? (United States)

    Guthrie, James W.

    Financial estimates for achieving the six national education goals proposed at the Charlottesville Education Summit are provided in this paper. Specific objectives under each goal, as outlined by the National Goals Panel, are assessed. A conclusion is that although the cost estimates have involved huge assumptions and sometimes wide variations,…

  15. The selfish goal meets the selfish gene. (United States)

    Neuberg, Steven L; Schaller, Mark


    The connection between selfish genes and selfish goals is not merely metaphorical. Many goals that shape contemporary cognition and behavior are psychological products of evolutionarily fundamental motivational systems and thus are phenotypic manifestations of genes. An evolutionary perspective can add depth and nuance to our understanding of "selfish goals" and their implications for human cognition and behavior.

  16. From Desires, Obligations and Norms to Goals

    NARCIS (Netherlands)

    Dignum, F.P.M.; Kinny, D.; Sonenberg, L.


    Traditional models of agents based on Beliefs, Desires and Intentions usually only include either desires or goals. Therefore the process whereby goals arise from desires is given scant attention. In this paper we argue that the inclusion of both desires and goals in the same model can be

  17. Goal Expectations as Predictors of Retirement Intentions (United States)

    Brougham, Ruby R.; Walsh, David A.


    The current study explored the contribution of personal goals to retirement decisions. A SMARTER methodology (to assess multiattribute utility) and taxonomy of human goals were used to investigate the relationship between older workers' personal goals and their retirement intentions. Two hundred and fifty-one employees of a large university,…




  19. Self-regulation through Goal Setting

    DEFF Research Database (Denmark)

    Koch, Alexander; Nafziger, Julia

    self-control problems. We show how goals permit self-regulation, but also that they are painful self-disciplining devices. Greater self-control problems therefore lead to stronger self-regulation through goals only up to a certain point. For severely present-biased preferences, the required goal...... for self-regulation is too painful and the individual rather gives up....

  20. Cookery demonstrations in GOAL supported clinics

    African Journals Online (AJOL)

    stunting are high, and various micronutrient deficiencies, including those of ... the household are the underlying causes seen in GOAL- assisted areas. ... feeding. Thus, the nutrition cookery demonstration activity has come to play an important role in mother and child health activities in GOAL-supported clinics and GOAL's.

  1. Parametric Study on Ultimate Failure Criteria of Elbow Piping Components in Seismically Isolated NPP

    Energy Technology Data Exchange (ETDEWEB)

    Hahm, Dae Gi; Ki, Min Kyu [KAERI, Daejeon (Korea, Republic of); Jeon, Bub Gyu; Kim, Nam Sik [Pusan National University, Busan (Korea, Republic of)


    It is well known that the interface pipes between isolated and non-isolated structures will become the most critical in the seismically isolated NPPs. Therefore, seismic performance of such interface pipes should be evaluated comprehensively especially in terms of the seismic fragility capacity. To evaluate the seismic capacity of interface pipes in the isolated NPP, firstly, we should define the failure mode and failure criteria of critical pipe components. Hence, in this study, we performed the dynamic tests of elbow components which were installed in a seismically isolated NPP, and evaluated the ultimate failure mode and failure criteria by using the test results. To do this, we manufactured 25 critical elbow component specimens and performed cyclic loading tests under the internal pressure condition. The failure mode and failure criteria of a pipe component will be varied by the design parameters such as the internal pressure, pipe diameter, loading type, and loading amplitude. From the tests, we assessed the effects of the variation parameters onto the failure criteria. For the tests, we generated the seismic input protocol of relative displacement between the ends of elbow component. In this paper, elbow in piping system was defined as a fragile element and numerical model was updated by component test. Failure mode of piping component under seismic load was defined by the dynamic tests of ultimate pipe capacity. For the interface piping system, the seismic capacity should be carefully estimated since that the required displacement absorption capacity will be increased significantly by the adoption of the seismic isolation system. In this study, the dynamic tests were performed for the elbow components which were installed in an actual NPPs, and the ultimate failure mode and failure criteria were also evaluated by using the test results.

  2. Ultimate pressures achieved in TiZrV sputter-coated vacuum chambers

    CERN Document Server

    Benvenuti, Cristoforo; Ruzinov, V


    Two metre long, cylindrical vacuum chambers of diameter ranging from 34 to 100 mm, coated with TiZrV getter films by sputtering, have been baked for about 24 h at temperatures from 120 to 250 degrees C. The ultimate pressures achieved after bakeout were found to correspond to the ratio of the pressure gauge degassing to the effective pumping speed provided by the chamber at the location of the gauge. The results covering a pressure range from 10/sup -11/ Torr down to 10 /sup -13/ Torr are presented and discussed. (6 refs).

  3. DHC in Helsinki - The Ultimate Heating and Cooling Solution for a Large Urban Area

    Energy Technology Data Exchange (ETDEWEB)

    Wirgentius, Niko; Riipinen, Marko


    Since the 1950s there has been successful district energy business in Helsinki. It has been the main factor for superior energy efficiency and low CO2 emissions both in heating and cooling as well as providing clean air for the metropolitan area. The system has been grown by commercial basis based on customers' own willingness to select district energy solution. It also provided a profitable energy business to local energy company, Helsinki Energy. Helsinki DHC system is a good example of ultimate urban energy solution that provides benefits for the customer, energy company, metropolitan area and for the whole society as well.

  4. Investigations on the ultimate compressive strength of composite plates with geometrical imperfections

    DEFF Research Database (Denmark)

    Misirlis, K.; Downes, J.; Dow, R.S.


    with initial geometric imperfections. This paper presents the validation of finite element models against a series of plate tests that were performed within this framework and parametric studies that were carried out to identify the effects of geometric imperfections on the ultimate compressive strength......A series of studies has been performed within the MARSTRUCT Network of Excellence on Marine Structures in order to investigate the buckling response of glass fibre reinforced polymer plates. These studies include the fabrication, testing and finite element analysis of a large number of plates...

  5. Lava ultimate resin nano ceramic for CAD/ CAM: customization case study. (United States)

    Koller, M; Arnetzl, G V; Holly, L; Arnetzl, G


    Lava Ultimate Resin Nano Ceramic (RNC) blocks are innovative new CAD/CAM materials that make it possible to achieve superior esthetic results in easy steps. The blocks are made of nano ceramic particles embedded in a highly cured resin matrix. Therefore, composite materials can be used to characterize and adjust resin nano ceramic restorations after milling. The milled RNC restorations can be individualized intra-orally or extra-orally, either before or after insertion. Unlike conventional ceramic restorations, customization and glaze firing is neither necessary nor possible with RNC restorations. This opens up the opportunity for intraoral individualization and adaptation of the restorations.

  6. Reflecting on impact, changes and continuities: restructuring workplace cultures: the ultimate work-family challenge.


    Lewis, Suzan


    Purpose – The purpose of this paper is to reflect on the paper “Restructuring workplace cultures: the ultimate work-family challenge?” is published in Women in Management Review, Vol. 16 No. 1, 2001, pp. 21-9. \\ud \\ud Design/methodology/approach – The impact of the paper is considered within a framework that takes account of national discursive and political contexts in the UK in 2001 and in the present and uses a gendered organisation lens. \\ud \\ud Findings – The 2001 paper demonstrates that...

  7. The legal ensurance of underground ultimate storage of radioactive wastes without risk

    International Nuclear Information System (INIS)

    Prasse, R.


    1. The legal position towards the property owner: a) with a view to the freedom of property claim, b) in the light of the influence of the property owner. 2. The legal position towards the neighbouring property owners: a) resistance rights of the body corporate responsible for the ultimate storage, b) resistance rights of the neighbouring property owner. 3. The legal position towards those authorized to mine: a) mining free minerals, b) mining minerals reserved for the state. 4. The legal position towards prospectors. (orig./HP) [de

  8. Seismic proving test of ultimate piping strength (current status of preliminary tests)

    International Nuclear Information System (INIS)

    Suzuki, K.; Namita, Y.; Abe, H.; Ichihashi, I.; Suzuki, K.; Ishiwata, M.; Fujiwaka, T.; Yokota, H.


    In 1998 Fiscal Year, the 6 year program of piping tests was initiated with the following objectives: i) to clarify the elasto-plastic response and ultimate strength of nuclear piping, ii) to ascertain the seismic safety margin of the current seismic design code for piping, and iii) to assess new allowable stress rules. In order to resolve extensive technical issues before proceeding on to the seismic proving test of a large-scale piping system, a series of preliminary tests of materials, piping components and simplified piping systems is intended. In this paper, the current status of the material tests and the piping component tests is reported. (author)

  9. A New Algorithm for Determining Ultimate Pit Limits Based on Network Optimization


    Ali Asghar Khodayari


    One of the main concerns of the mining industry is to determine ultimate pit limits. Final pit is a collection of blocks, which can be removed with maximum profit while following restrictions on the slope of the mine’s walls. The size, location and final shape of an open-pit are very important in designing the location of waste dumps, stockpiles, processing plants, access roads and other surface facilities as well as in developing a production program. There are numerous methods for designing...

  10. Pathogenesis of Graves' disease and therapeutic implications

    International Nuclear Information System (INIS)

    Seif, F.J.


    Graves' disease presents itself clinically mainly as hyperthyroidism and infiltrative ophthalmopathy and to a minimal extent also as dermopathy and acropachy. Autoimmune processes are the basic pathogenesis. Stimulating antibodies against the TSH receptor cause hyperthyroidism. Autoantibodies and autoreactive T lymphocytes against primarily thyroidal antigens cross-react with similar antigens of the eye muscles and orbital connective tissue, thus spreading the disease from the thyroid to the eyes. The therapeutic goal comprises not only the treatment of hyperthyroidism, but also the induction of a steady immuntolerance in order to minimize the irreversible damage to the eye. The therapeutic armamentarium is formed by antithyroid drugs, glucocorticoids, retrobulbar radition and thyroid ablation, either by nearly total thyroidectomy or by radioiodine. The different indications for both ablative procedures are discussed. (orig.) [de

  11. Quantitative HTGR safety and forced outage goals

    International Nuclear Information System (INIS)

    Houghton, W.J.; Parme, L.L.; Silady, F.A.


    A key step in the successful implementation of the integrated approach is the definition of the overall plant-level goals. To be effective, the goals should provide clear statements of what is to be achieved by the plant. This can be contrasted to the current practice of providing design-prescriptive criteria which implicitly address some higher-level objective but restrict the designer's flexibility. Furthermore, the goals should be quantifiable in such a way that satisfaction of the goal can be measured. In the discussion presented, two such plant-level goals adopted for the HTGR and addressing the impact of unscheduled occurrences are described. 1 fig

  12. Goals of measurement systems for international safeguards

    International Nuclear Information System (INIS)

    de Montmollin, J.M.; Weinstock, E.V.


    The safeguards applied by the International Atomic Energy Agency are based on technical performance goals and criteria that have been developed, but not officially adopted by the Agency. The goals derive in part from the external consequences that safeguards are intended to prevent and in some cases on internal considerations of feasibility. To the extent that these goals may not be attainable, as may be the case with large-throughput bulk reprocessing plants, the Agency is placed in a difficult position. In this paper safeguards goals and criteria and their underlying rationales are critically examined. Suggestions for a more rational and workable structure of performance goals are offered

  13. Safety goals for commercial nuclear power plants

    International Nuclear Information System (INIS)

    Roe, J.W.


    In its official policy statement on safety goals for the operation of nuclear power plants, the Nuclear Regulatory Commission (NRC) set two qualitative goals, supported by two quantitative objectives. These goals are that (1) individual members of the public should be provided a level of protection from the consequences of nuclear power plant operation such that individuals bear no significant additional risk to life and health; and (2) societal risks to life and health from nuclear power plant operation should be comparable to or less than the risks of generating electricity by viable competing technologies and should not be a significant addition to other societal risks. As an alternative, this study proposes four quantitative safety goals for nuclear power plants. It begins with an analysis of the NRC's safety-goal development process, a key portion of which was devoted to delineating criteria for evaluating goal-development methods. Based on this analysis, recommendations for revision of the NRC's basic benchmarks for goal development are proposed. Using the revised criteria, NRC safety goals are evaluated, and the alternative safety goals are proposed. To further support these recommendations, both the NRC's goals and the proposed goals are compared with the results of three major probabilistic risk assessment studies. Finally, the potential impact of these recommendations on nuclear safety is described

  14. The Best of Two Worlds. Article 6 mechanisms shall contribute to Sustainable Development Goals (SDGs)

    DEFF Research Database (Denmark)

    Olsen, Karen Holm; Soezer, Alexandra


    The Paris Agreement and the UN Sustainable Development Goals (SDGs) were two milestone achievements in 2015. The Intended Nationally Determined Contributions (INDCs) put forward by Parties before the Climate Conference in Paris will have to be fully embedded in the 2030 agenda to achieve truly...... transformational, lasting impacts for low carbon and SDGs and, ultimately, resilient communities that are able to quickly respond to and recover from adverse situations....

  15. [Therapeutic algorithm of idiopathic scoliosis in children]. (United States)

    Ciortan, Ionica; Goţia, D G


    Acquired deformations of spinal cord (scoliosis, kyphosis, lordosis) represent a frequent pathology in child; their treatment is complex, with variable results which depend on various parameters. Mild scoliosis, with an angle less than 30 degrees, is treated with physiotherapy and regular follow-up. If the angle is higher than 30 degrees, the orthopedic corset is required; the angle over 45 degrees impose surgically correction. The indications of every therapeutic method depend on many factors, the main target of the treatment is to prevent the aggravation of the curvature; concerning the surgery, the goal is to obtain a correction as normal as possible of the spinal axis.

  16. The theoretical ultimate magnetoelectric coefficients of magnetoelectric composites by optimization design

    International Nuclear Information System (INIS)

    Wang, H.-L.; Liu, B.


    This paper investigates what is the largest magnetoelectric (ME) coefficient of ME composites, and how to realize it. From the standpoint of energy conservation, a theoretical analysis is carried out on an imaginary lever structure consisting of a magnetostrictive phase, a piezoelectric phase, and a rigid lever. This structure is a generalization of various composite layouts for optimization on ME effect. The predicted theoretical ultimate ME coefficient plays a similar role as the efficiency of ideal heat engine in thermodynamics, and is used to evaluate the existing typical ME layouts, such as the parallel sandwiched layout and the serial layout. These two typical layouts exhibit ME coefficient much lower than the theoretical largest values, because in the general analysis the stress amplification ratio and the volume ratio can be optimized independently and freely, but in typical layouts they are dependent or fixed. To overcome this shortcoming and achieve the theoretical largest ME coefficient, a new design is presented. In addition, it is found that the most commonly used electric field ME coefficient can be designed to be infinitely large. We doubt the validity of this coefficient as a reasonable ME effect index and consider three more ME coefficients, namely the electric charge ME coefficient, the voltage ME coefficient, and the static electric energy ME coefficient. We note that the theoretical ultimate value of the static electric energy ME coefficient is finite and might be a more proper measure of ME effect

  17. Experimental study on ultimate strength and strain behavior of concrete under biaxial compressive stresses

    International Nuclear Information System (INIS)

    Onuma, Hiroshi; Aoyagi, Yukio


    The purpose of this investigation was to study the ultimate strength failure mode and deformation behavior of concrete under short-term biaxial compressive stresses, as an aid to design and analyze the concrete structures subjected to multiaxial compression such as prestressed or reinforced concrete vessel structures. The experimental work on biaxial compression was carried out on the specimens of three mix proportions and different ages with 10cm x 10cm x 10cm cubic shape in a room controlled at 20 0 C. The results are summarized as follows. (1) To minimize the surface friction between specimens and loading platens, the pads of teflon sheets coated with silicone grease were used. The coefficient of friction was measured and was 3 percent on the average. (2) The test data showed that the strength of the concrete subjected to biaxial compression increased as compared to uniaxial compressive strength, and that the biaxial strength increase was mainly dependent on the ratio of principal stresses, and it was hardly affected by mix proportions and ages. (3) The maximum increase of strength, which occurred at the stress ratio of approximately sigma 2 /sigma 1 = 0.6, was about 27 percent higher than the uniaxial strength of concrete. (4) The ultimate strength in case of biaxial compression could be approximated by the parabolic equation. (Kako, I.)

  18. Secondary Moments due to Prestressing with Different Bond at the Ultimate Limit State

    Directory of Open Access Journals (Sweden)

    Halvoník Jaroslav


    Full Text Available Secondary effects of prestressing develop in statically indeterminate structures (e.g., continuous beams due to the restraint of deformations imposed by hyperstatic restraints. These effects may significantly influence internal forces and stresses in prestressed structures. Secondary effects are influenced by the redundancy of a structural system, which raises the question of whether they will remain constant after a change in the structural system, e.g., due to the development of plastic hinge(s in a critical cross-section(s or after the development of a kinematic mechanism, or if they will disappear when the structure changes into a sequence of simply supported beams. The paper deals with an investigation of the behavior of continuous post-tensioned beams subjected to an ultimate load with significant secondary effects from prestressing. A total of 6 two-span beams prestressed by tendons with different bonds were tested in a laboratory with a load that changed their structural system into a kinematic mechanism. The internal forces and secondary effects of the prestressing were controlled through measurements of the reactions in all the supports. The results revealed that the secondary effects remained as a permanent part of the action on the experimental beams, even after the development of the kinematic mechanism. The results obtained confirmed that secondary effects should be included in all combinations of actions for verifications of ultimate limit states (ULS.

  19. Secondary Moments due to Prestressing with Different Bond at the Ultimate Limit State (United States)

    Halvoník, Jaroslav; Pažma, Peter; Vida, Radoslav


    Secondary effects of prestressing develop in statically indeterminate structures (e.g., continuous beams) due to the restraint of deformations imposed by hyperstatic restraints. These effects may significantly influence internal forces and stresses in prestressed structures. Secondary effects are influenced by the redundancy of a structural system, which raises the question of whether they will remain constant after a change in the structural system, e.g., due to the development of plastic hinge(s) in a critical cross-section(s) or after the development of a kinematic mechanism, or if they will disappear when the structure changes into a sequence of simply supported beams. The paper deals with an investigation of the behavior of continuous post-tensioned beams subjected to an ultimate load with significant secondary effects from prestressing. A total of 6 two-span beams prestressed by tendons with different bonds were tested in a laboratory with a load that changed their structural system into a kinematic mechanism. The internal forces and secondary effects of the prestressing were controlled through measurements of the reactions in all the supports. The results revealed that the secondary effects remained as a permanent part of the action on the experimental beams, even after the development of the kinematic mechanism. The results obtained confirmed that secondary effects should be included in all combinations of actions for verifications of ultimate limit states (ULS).

  20. Bootstrap calculation of ultimate strength temperature maxima for neutron irradiated ferritic/martensitic steels (United States)

    Obraztsov, S. M.; Konobeev, Yu. V.; Birzhevoy, G. A.; Rachkov, V. I.


    The dependence of mechanical properties of ferritic/martensitic (F/M) steels on irradiation temperature is of interest because these steels are used as structural materials for fast, fusion reactors and accelerator driven systems. Experimental data demonstrating temperature peaks in physical and mechanical properties of neutron irradiated pure iron, nickel, vanadium, and austenitic stainless steels are available in the literature. A lack of such an information for F/M steels forces one to apply a computational mathematical-statistical modeling methods. The bootstrap procedure is one of such methods that allows us to obtain the necessary statistical characteristics using only a sample of limited size. In the present work this procedure is used for modeling the frequency distribution histograms of ultimate strength temperature peaks in pure iron and Russian F/M steels EP-450 and EP-823. Results of fitting the sums of Lorentz or Gauss functions to the calculated distributions are presented. It is concluded that there are two temperature (at 360 and 390 °C) peaks of the ultimate strength in EP-450 steel and single peak at 390 °C in EP-823.

  1. Application of risk-informed design methods to select the PSACS ultimate heat sink

    International Nuclear Information System (INIS)

    Elliott, Michael A.; Apostolakis, George E.


    In the early phases of advanced system design, information is scarce. The technologies, components and processes to be used have not been specified adequately or are not well understood and uncertainties are very large. Yet, it is during these early phases that design teams and other stakeholders are required to make critical decisions to guide the development of the system. To aid in this decision making, a formal process is proposed based on the Analytic-Deliberative Decision-Making Process (ADP) that allows stakeholders to synthesize rationally their knowledge and experience and facilitate learning and sharing of best practices. The ADP identifies and prioritizes attributes relevant to a decision problem and supports the formulation of metrics to measure the performance of different design options. This paper reports on an application of the ADP to the selection of an ultimate heat sink for the Flexible Conversion Ratio (FCR) reactor's Passive Secondary Auxiliary Cooling System (PSACS). Two ultimate heat sink options are identified and evaluated, air and water.

  2. Plasticity and constraints on social evolution in African mole-rats: ultimate and proximate factors. (United States)

    Faulkes, Chris G; Bennett, Nigel C


    Here, we review comparative studies of African mole-rats (family Bathyergidae) to explain how constraints acting at the ultimate (environmental) and proximate (organismal) levels have led to convergent gains and losses of sociality within this extensive adaptive radiation of subterranean rodents endemic to sub-Saharan Africa. At the ultimate level, living in environments that range from mesic through to arid has led to both variation and flexibility in social organization among species, culminating in the pinnacle of social evolution in the eusocial naked and Damaraland mole-rats (Heterocephalus glaber and Fukomys damarensis). The common mole-rat (Cryptomys hottentotus) provides a model example of how plasticity in social traits exists within a single species inhabiting areas with different ecological constraint. At the proximate level, reproductive strategies and cooperative breeding may be constrained by the correlated evolution of a suite of traits including physiological suppression of reproduction, the development of physiological and morphological castes, and the mode of ovulatory control and seasonality in breeding. Furthermore, recent neurobiological advances indicate that differential patterns of neurotransmitter expression within the forebrain may underpin (and limit) either a solitary or group living/cooperative lifestyle not only in mole-rats, but also more widely among disparate mammalian taxa.

  3. Evaluation of the ultimate pressure capacity of rectangular HVAC ducts for nuclear pwoer plants

    International Nuclear Information System (INIS)

    Wedellsborg, B.W.


    Typical Category I HVAC ducts in a nuclear plant must be designed for loads and load combinations including positive and negative pressure loads which are generated due to the normal operation and postulated accident conditions. These pressure loads most often govern the design of the HVAC ducts. Structural design criteria are presently based on the AISI Code which limits the duct panel width-to-thickness ratio to a maximum of 500 and the maximum height-to-thickness ratio to 200, unless it can be shown by structural tests that larger ratios can be used. Test Programs performed on rectangular HVAC ducts subjected to vacumm loads have substantiated the use of ducts having panel width to thickness ratios of up to 1600. The results of the test programs were subsequently incorporated into the design through a more rational analytical design method which was developed from and correlates well with the test results. The purpose of this paper is to present the analytical design method and its correlation with the test results. Simple formulae for the design of rectangular HVAC ducts are presented. Lower bound values of duct sheet, and stiffener ultimate loads are derived, and correlated with recent test results. Analytically predicted ultimate pressures are also compared with other available duct test data

  4. ULtiMATE system for rapid assembly of customized TAL effectors.

    Directory of Open Access Journals (Sweden)

    Junjiao Yang

    Full Text Available Engineered TAL-effector nucleases (TALENs and TALE-based constructs have become powerful tools for eukaryotic genome editing. Although many methods have been reported, it remains a challenge for the assembly of designer-based TALE repeats in a fast, precise and cost-effective manner. We present an ULtiMATE (USER-based Ligation Mediated Assembly of TAL Effector system for speedy and accurate assembly of customized TALE constructs. This method takes advantage of uracil-specific excision reagent (USER to create multiple distinct sticky ends between any neighboring DNA fragments for specific ligation. With pre-assembled templates, multiple TALE DNA-binding domains could be efficiently assembled in order within hours with minimal manual operation. This system has been demonstrated to produce both functional TALENs for effective gene knockout and TALE-mediated gene-specific transcription activation (TALE-TA. The feature of both ease-of-operation and high efficiency of ULtiMATE system makes it not only an ideal method for biologic labs, but also an approach well suited for large-scale assembly of TALENs and any other TALE-based constructions.

  5. Ultimate shearing strength of aseismatic walls with many small holes for reactor buildings

    International Nuclear Information System (INIS)

    Yoshizaki, Seiji; Ezaki, Tetsuro; Korenaga, Takeyoshi; Sotomura, Kentaro.


    The aseismatic walls for reactor buildings have complicated forms, and are characterized by large wall thickness and high reinforcement ratio as compared with ordinary aseismatic walls. The forms are mainly box, cylinder or irregular polygonal prism and their combination. The design of the walls with many small holes has been performed on the basis of the reinforced concrete structure calculation standard of the Architectural Institute of Japan, following the case with large opening. When there are many small holes, the arrangement of reinforcement for the openings becomes complex, and the construction is difficult. It is necessary to rationalize the design and to simplify the reinforcement work. Under the background like this, the experiment to examine the shearing property in bending of the aseismatic walls with many small holes for reactor buildings was carried out, and horizontal loading test was performed on 43 specimens. The method of calculating the ultimate shearing strength of a wall without opening was proposed, and the method of applying it to a wall with many small holes is shown. The experimental method and the results, the examination of the experimental results, and the ultimate shearing strength of the aseismatic walls are reported. (Kako, I.)

  6. Ultimate strength performance of tankers associated with industry corrosion addition practices

    Directory of Open Access Journals (Sweden)

    Kim Do Kyun


    Full Text Available In the ship and offshore structure design, age-related problems such as corrosion damage, local denting, and fatigue damage are important factors to be considered in building a reliable structure as they have a significant influence on the residual structural capacity. In shipping, corrosion addition methods are widely adopted in structural design to prevent structural capacity degradation. The present study focuses on the historical trend of corrosion addition rules for ship structural design and investigates their effects on the ultimate strength performance such as hull girder and stiffened panel of double hull oil tankers. Three types of rules based on corrosion addition models, namely historic corrosion rules (pre-CSR, Common Structural Rules (CSR, and harmonised Common Structural Rules (CSRH are considered and compared with two other corrosion models namely UGS model, suggested by the Union of Greek Shipowners (UGS, and Time-Dependent Corrosion Wastage Model (TDCWM. To identify the general trend in the effects of corrosion damage on the ultimate longitudinal strength performance, the corrosion addition rules are applied to four representative sizes of double hull oil tankers namely Panamax, Aframax, Suezmax, and VLCC. The results are helpful in understanding the trend of corrosion additions for tanker structures

  7. Ultimate strength performance of tankers associated with industry corrosion addition practices

    Directory of Open Access Journals (Sweden)

    Do Kyun Kim


    Full Text Available In the ship and offshore structure design, age-related problems such as corrosion damage, local denting, and fatigue damage are important factors to be considered in building a reliable structure as they have a significant influence on the residual structural capacity. In shipping, corrosion addition methods are widely adopted in structural design to prevent structural capacity degradation. The present study focuses on the historical trend of corrosion addition rules for ship structural design and investigates their effects on the ultimate strength performance such as hull girder and stiffened panel of double hull oil tankers. Three types of rules based on corrosion addition models, namely historic corrosion rules (pre-CSR, Common Structural Rules (CSR, and harmonised Common Structural Rules (CSRH are considered and compared with two other corrosion models namely UGS model, suggested by the Union of Greek Shipowners (UGS, and Time-Dependent Corrosion Wastage Model (TDCWM. To identify the general trend in the effects of corrosion damage on the ultimate longitudinal strength performance, the corrosion addition rules are applied to four representative sizes of double hull oil tankers namely Panamax, Aframax, Suezmax, and VLCC. The results are helpful in understanding the trend of corrosion additions for tanker structures.

  8. A New Algorithm for Determining Ultimate Pit Limits Based on Network Optimization

    Directory of Open Access Journals (Sweden)

    Ali Asghar Khodayari


    Full Text Available One of the main concerns of the mining industry is to determine ultimate pit limits. Final pit is a collection of blocks, which can be removed with maximum profit while following restrictions on the slope of the mine’s walls. The size, location and final shape of an open-pit are very important in designing the location of waste dumps, stockpiles, processing plants, access roads and other surface facilities as well as in developing a production program. There are numerous methods for designing ultimate pit limits. Some of these methods, such as floating cone algorithm, are heuristic and do not guarantee to generate optimum pit limits. Other methods, like Lerchs–Grossmann algorithm, are rigorous and always generate the true optimum pit limits. In this paper, a new rigorous algorithm is introduced. The main logic in this method is that only positive blocks, which can pay costs of their overlying non-positive blocks, are able to appear in the final pit. Those costs may be paid either by positive block itself or jointly with other positive blocks, which have the same overlying negative blocks. This logic is formulated using a network model as a Linear Programming (LP problem. This algorithm can be applied to two- and three-dimension block models. Since there are many commercial programs available for solving LP problems, pit limits in large block models can be determined easily by using this method.

  9. Self-regulation of unattainable goals in suicide attempters: the relationship between goal disengagement, goal reengagement and suicidal ideation.

    LENUS (Irish Health Repository)

    O'Connor, Rory C


    There is growing interest in models of adaptive self-regulation. Recent research suggests that goal disengagement and goal reengagement (i.e., goal adjustment) are implicated in the self-regulation of emotion. This study extends the self-regulation research to investigate the utility of goal adjustment in understanding suicidal risk. To this end, two hundred adults hospitalised following a suicidal episode completed a range of clinical and psychological measures in hospital and were followed up approximately 2.5 months after discharge (Time 2). Hierarchical regression analyses showed that goal reengagement predicted suicidal ideation at Time 2. In addition, the lack of goal reengagement was especially pernicious when reported concomitantly with high disengagement. These predictive effects were independent of baseline mood, attempt status and suicidal intent. The theoretical and clinical implications are discussed.

  10. Empathic curiosity: resolving goal conflicts that generate emotional distress. (United States)

    McEvoy, P; Baker, D; Plant, R; Hylton, K; Mansell, W


    The quality of the therapeutic alliance between therapist and client is consistently identified as a key component of cognitive behavioural interventions. However, relatively little is known about the causal mechanisms that generate the effects that are ascribed to the therapeutic alliance. This paper outlines how one such causal mechanism, empathic curiosity, may operate. The explanation is rooted in control theory, a theory that explains the link between our experiences and our goal-directed behaviour. Empathic curiosity is underpinned by the core skills of empathic listening and maintaining a curious attitude. From a control theory perspective, the value of this type of listening may be reinforced when speak to people about their salient concerns, as they perceive them in the current flow of their conscious thoughts. This can be facilitated by linking curious questions to the non-verbal disruptions in their body posture and conversational flow. The approach is illustrated using three case examples. In all three examples, the clients involved were able to reflect upon and re-organize conflicting goals that had been a source of significant emotional distress. © 2012 Blackwell Publishing.

  11. Teachers' instructional goals for science practice: Identifying knowledge gaps using cultural-historical activity theory (CHAT) (United States)

    Farrar, Cynthia Hamen

    In AP Biology, the course goal, with respect to scientific acts and reasoning, has recently shifted toward a reform goal of science practice, where the goal is for students to have a scientific perspective that views science as a practice of a community rather than a body of knowledge. Given this recent shift, this study is interested in the gaps that may exist between an individual teacher's instructional goal and the goals of the AP Biology course. A Cultural-Historical Activity Theory (CHAT) methodology and perspective is used to analyze four teachers' knowledge, practice, and learning. Teachers have content knowledge for teaching, a form of knowledge that is unique for teaching called specialized content knowledge. This specialized content knowledge (SCK) defines their instructional goals, the student outcomes they ultimately aim to achieve with their students. The study employs a cultural-historical continuum of scientific acts and reasoning, which represents the development of the AP Biology goal over time, to study gaps in their instructional goal. The study also analyzes the contradictions within their teaching practice and how teachers address those contradictions to shift their instructional practice and learn. The findings suggest that teachers have different interpretations of the AP Biology goals of science practice, placing their instructional goal at different points along the continuum. Based on the location of their instructional goal, different micro-communities of teachers exist along the continuum, comprised of teachers with a shared goal, language, and culture of their AP Biology teaching. The in-depth study of one teacher's AP Biology teaching, using a CHAT perspective, provides a means for studying the mechanisms that connect SCK to classroom actions and ultimately to instructional practice. CHAT also reveals the nature and importance of contradictions or cognitive dissonance in teacher learning and the types of support teachers need to

  12. Therapeutic nanomedicine surmounts the limitations of pharmacotherapy

    Directory of Open Access Journals (Sweden)

    Odiba Arome


    Full Text Available Science always strives to find an improved way of doing things and nanoscience is one such approach. Nanomaterials are suitable for pharmaceutical applications mostly because of their size which facilitates absorption, distribution, metabolism and excretion of the nanoparticles. Whether labile or insoluble nanoparticles, their cytotoxic effect on malignant cells has moved the use of nanomedicine into focus. Since nanomedicine can be described as the science and technology of diagnosing, treating and preventing diseases towards ultimately improving human health, a lot of nanotechnology options have received approval by various regulatory agencies. Nanodrugs also have been discovered to be more precise in targeting the desired site, hence maximizing the therapeutic effects, while minimizing side-effects on the rest of the body. This unique property and more has made nanomedicine popular in therapeutic medicine employing nanotechnology in genetic therapy, drug encapsulation, enzyme manipulation and control, tissue engineering, target drug delivery, pharmacogenomics, stem cell and cloning, and even virus-based hybrids. This review highlights nanoproducts that are in development and have gained approval through one clinical trial stage or the other.

  13. Long-term experience in salt mining and experience in salt mine decommissioning - a chance for ultimate storage?

    International Nuclear Information System (INIS)

    Sitz, P.; Rauche, H.


    The author discusses similarities between salt mining and ultimate storage and the possibility of using abandoned salt mines as ultimate storage site. He states that with all the numeric prediction tools now available, expert knowledge of mining engineers is still indispensable [de

  14. Stroke and Therapeutic Hypothermia

    Directory of Open Access Journals (Sweden)

    Ozlem Ozkan Kuscu


    Full Text Available Stroke is significant cause of morbidity and mortality caused by disruption of blood flow. Neural injury occurs with two stage; while primary neural injury occurs with disruption of blood flow, after days and hours with metabolic processes secondary injury develops in tissues which is non injured in the first stage. Therefore it is important to prevent and treat the secondary injury as much as preventing and treating the primary neural injury. In this article developing pathophysiological changes after stroke, mechanisms of therapeutic hypothermia, application methods, the factors that determine the effectiveness, side effects and complications were reviewed. [Archives Medical Review Journal 2016; 25(3.000: 351-368

  15. Neurodevelopmental Treatment (NDT): Therapeutic Intervention and Its Efficacy. (United States)

    Stern, Francine Martin; Gorga, Delia


    Use of neurodevelopmental treatment, also known as the Bobath method, is discussed, including its history, philosophy, goals, and treatment emphasis with infants and children with movement disorders. Examples of children before and after therapeutic intervention illustrate use of the technique, and controversies in measuring therapy efficacy are…

  16. Vocational Education and Training and the Therapeutic Turn (United States)

    Hyland, Terry


    The concept of "therapeutic education" is being increasingly used in contemporary education policy studies to identify learning initiatives which are dominated by objectives linked to personal and social skills, emotional intelligence and building self-esteem. Contemporary educational goals connected with such strategies have been…

  17. Pharmacogenetics approach to therapeutics. (United States)

    Koo, Seok Hwee; Lee, Edmund Jon Deoon


    1. Pharmacogenetics refers to the study of genetically controlled variations in drug response. Functional variants caused by single nucleotide polymorphisms (SNPs) in genes encoding drug-metabolising enzymes, transporters, ion channels and drug receptors have been known to be associated with interindividual and interethnic variation in drug response. Genetic variations in these genes play a role in influencing the efficacy and toxicity of medications. 2. Rapid, precise and cost-effective high-throughput technological platforms are essential for performing large-scale mutational analysis of genetic markers involved in the aetiology of variable responses to drug therapy. 3. The application of a pharmacogenetics approach to therapeutics in general clinical practice is still far from being achieved today owing to various constraints, such as limited accessibility of technology, inadequate knowledge, ambiguity of the role of variants and ethical concerns. 4. Drug actions are determined by the interplay of several genes encoding different proteins involved in various biochemical pathways. With rapidly emerging SNP discovery technological platforms and widespread knowledge on the role of SNPs in disease susceptibility and variability in drug response, the pharmacogenetics approach to therapeutics is anticipated to take off in the not-too-distant future. This will present profound clinical, economic and social implications for health care.

  18. Therapeutic nuclear medicine

    International Nuclear Information System (INIS)

    Baum, Richard P.


    Discusses all aspects of radionuclide therapy, including basic principles, newly available treatments, regulatory requirements, and future trends. Provides the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Explains the role of the therapeutic nuclear physician in effectively coordinating a diverse multidisciplinary team. Written by leading experts. The recent revolution in molecular biology offers exciting new opportunities for targeted radionuclide therapy. The selective irradiation of tumor cells through molecular biological mechanisms is now permitting the radiopharmaceutical control of tumors that are unresectable and unresponsive to either chemotherapy or conventional radiotherapy. In this up-to-date, comprehensive book, world-renowned experts discuss the basic principles of radionuclide therapy, explore in detail the available treatments, explain the regulatory requirements, and examine likely future developments. The full range of clinical applications is considered, including thyroid cancer, hematological malignancies, brain tumors, liver cancer, bone and joint disease, and neuroendocrine tumors. The combination of theoretical background and practical information will provide the reader with all the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Careful attention is also paid to the important role of the therapeutic nuclear physician in delivering the effective coordination of a diverse multidisciplinary team that is essential to the safe provision of treatment.

  19. Mechanisms of Plasma Therapeutics (United States)

    Graves, David


    In this talk, I address research directed towards biomedical applications of atmospheric pressure plasma such as sterilization, surgery, wound healing and anti-cancer therapy. The field has seen remarkable growth in the last 3-5 years, but the mechanisms responsible for the biomedical effects have remained mysterious. It is known that plasmas readily create reactive oxygen species (ROS) and reactive nitrogen species (RNS). ROS and RNS (or RONS), in addition to a suite of other radical and non-radical reactive species, are essential actors in an important sub-field of aerobic biology termed ``redox'' (or oxidation-reduction) biology. It is postulated that cold atmospheric plasma (CAP) can trigger a therapeutic shielding response in tissue in part by creating a time- and space-localized, burst-like form of oxy-nitrosative stress on near-surface exposed cells through the flux of plasma-generated RONS. RONS-exposed surface layers of cells communicate to the deeper levels of tissue via a form of the ``bystander effect,'' similar to responses to other forms of cell stress. In this proposed model of CAP therapeutics, the plasma stimulates a cellular survival mechanism through which aerobic organisms shield themselves from infection and other challenges.

  20. Therapeutic nuclear medicine

    Energy Technology Data Exchange (ETDEWEB)

    Baum, Richard P. (ed.) [ENETS Center of Excellence, Bad Berka (Germany). THERANOSTICS Center for Molecular Radiotherapy and Molecular Imaging


    Discusses all aspects of radionuclide therapy, including basic principles, newly available treatments, regulatory requirements, and future trends. Provides the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Explains the role of the therapeutic nuclear physician in effectively coordinating a diverse multidisciplinary team. Written by leading experts. The recent revolution in molecular biology offers exciting new opportunities for targeted radionuclide therapy. The selective irradiation of tumor cells through molecular biological mechanisms is now permitting the radiopharmaceutical control of tumors that are unresectable and unresponsive to either chemotherapy or conventional radiotherapy. In this up-to-date, comprehensive book, world-renowned experts discuss the basic principles of radionuclide therapy, explore in detail the available treatments, explain the regulatory requirements, and examine likely future developments. The full range of clinical applications is considered, including thyroid cancer, hematological malignancies, brain tumors, liver cancer, bone and joint disease, and neuroendocrine tumors. The combination of theoretical background and practical information will provide the reader with all the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Careful attention is also paid to the important role of the therapeutic nuclear physician in delivering the effective coordination of a diverse multidisciplinary team that is essential to the safe provision of treatment.

  1. Health care quality, access, cost, workforce, and surgical education: the ultimate perfect storm. (United States)

    Schwartz, Marshall Z


    The discussions on health care reform over the past two years have focused on cost containment while trying to maintain quality of care. Focusing on just cost and quality unfortunately does not address other very important factors that impact on our health care delivery system. Availability of a well-trained workforce, maintaining the sophisticated medical/surgical education system, and ultimately access to quality care by the public are critical to maintaining and enhancing our health care delivery system. Unfortunately, all five of these components are under at risk. Thus, we have evolving the ultimate perfect storm affecting our health care delivery system. Although not ideal and given the uniqueness of our population and their expectations, our current delivery system is excellent compared to other countries. However, the cost of our current system is rising at an alarming rate. Currently, health care consumes 17% of our gross domestic product. If our system is not revised this will continue to rise and by 2025 it will consume 48%. The dilemma, given the current state of our overall economy and rising debt, is how to address this major problem. Unfortunately, the Affordable Care Act, which is now law, does not address most of the issues and the cost was initially grossly under estimated. Furthermore, the law does not address the issues of workforce, maintaining our medical education system or ultimately, access. A major revision of our system will be necessary to truly create a system that protects and enhances all five of the components of our health care delivery system. To effectively accomplish this will require addressing those issues that lead to wasteful spending and diversion of our health care dollars to profit instead of care. Improved and efficient delivery systems that reduce complications, reduction of duplication of tertiary and quaternary programs or services within the same markets (i.e. regionalization of care), health insurance reform, and

  2. Integrated learning through student goal development. (United States)

    Price, Deborah; Tschannen, Dana; Caylor, Shandra


    New strategies are emerging to promote structure and increase learning in the clinical setting. Nursing faculty designed a mechanism by which integrative learning and situated coaching could occur more readily in the clinical setting. The Clinical Goals Initiative was implemented for sophomore-, junior-, and senior-level students in their clinical practicums. Students developed weekly goals reflecting three domains of professional nursing practice. Goals were shared with faculty and staff nurse mentors at the beginning of the clinical day to help guide students and mentors with planning for learning experiences. After 6 weeks, faculty and students were surveyed to evaluate project effectiveness. Faculty indicated that goal development facilitated clinical learning by providing more student engagement, direction, and focus. Students reported that goal development allowed them to optimize clinical learning opportunities and track their growth and progress. Faculty and students indicated the goals promoted student self-learning, autonomy, and student communication with nurse mentors and faculty. Copyright 2013, SLACK Incorporated.

  3. Safety goals for future nuclear power plants

    International Nuclear Information System (INIS)

    Todreas, Neil E.


    This talk presents technology goals developed for Generation IV nuclear energy systems that can be made available to the market by 2030 or earlier. These goals are defined in the broad areas of sustainability, safety and reliability, and economics. Sustainability goals focus on fuel utilization, waste management, and proliferation resistance. Safety and reliability goals focus on safe and reliable operation, investment protection, and essentially eliminating the need for emergency response. Economics goals focus on competitive life cycle and energy production costs and financial risk. Future reactors fall in three categories - those which are: Certified or derivatives; Designed to a reasonable extent and based on available technology; In conceptual form only with potential to most fully satisfy the GENIV goals

  4. Safety guidelines of ultimate hull girder strength for grounded container ships

    DEFF Research Database (Denmark)

    Kim, Do Kyun; Pedersen, Preben Terndrup; Paik, Jeom Kee


    Various accidents commonly occur on operating ships. The structural damage caused by such accidents is often accompanied by casualties and serious pollution. In this regard, an accidental risk-based approach that is in line with the Goal Based Standard (GBS) of the International Maritime Organiza...

  5. Investigation of Ultimate Strength of Composite Open-Web Joist-Girders


    Showalter, Sheldon Lee


    The goal of this research was to study several methods of generating composite action using open-web joist-girders, designed and manufactured by Nucor Corporation. In addition to comparing the relative performance of these systems, it was intended to determine whether the current accepted design procedure for composite joists could be extended to joist-girders.

  6. Parental goals and talk with toddlers


    Rowe, Meredith Lee; Casillas, Allison


    Myriad studies support a relation between parental beliefs and behaviours. This study adds to the literature by focusing on the specific relationship between parental goals and their communication with toddlers. Do parents with different goals talk about different topics with their children? Parents’ goals for their 30-month olds were gathered using semi-structured interviews with 47 primary caregivers, whereas the topics of conversations that took place during interactio...

  7. Achievement goals and interpersonal behaviour: How mastery and performance goals shape information exchange

    NARCIS (Netherlands)

    Poortvliet, P.M.; Janssen, O.; Van Yperen, N.W.; Van de Vliert, E.


    The present research examines the impact of achievement goals on task-related information exchange. Studies 1 and 2 reveal that relative to those with mastery goals or no goal, individuals pursuing performance goals were less open in their information giving to exchange partners. Study 2 further

  8. Performance-approach and performance-avoidance classroom goals and the adoption of personal achievement goals. (United States)

    Schwinger, Malte; Stiensmeier-Pelster, Joachim


    Students' perceptions of classroom goals influence their adoption of personal goals. To assess different forms of classroom goals, recent studies have favoured an overall measure of performance classroom goals, compared to a two-dimensional assessment of performance-approach and performance-avoidance classroom goals (PAVCG). This paper considered the relationship between students' perceptions of classroom goals and their endorsement of personal achievement goals. We proposed that three (instead of only two) classroom goals need to be distinguished. We aimed to provide evidence for this hypothesis by confirmatory factor analysis (CFA) and also by divergent associations between the respective classroom goal and students' personal goal endorsement. A total of 871 (474 female) 10th grade students from several German high schools participated in this study. Students responded to items assessing their perception of mastery, performance-approach, and performance-avoidance goals in the classroom. Additionally, the students reported how much they personally pursue mastery, performance-approach, and performance-avoidance goals. All items referred to German as a specific school subject. RESULTS.A CFA yielded empirical support for the proposed distinction of three (instead of only two) different kinds of classroom goals. Moreover, in hierarchical linear modelling (HLM) analyses all three classroom goals showed unique associations with students' personal goal adoption. The findings emphasized the need to distinguish performance-approach and PAVCG. Furthermore, our results suggest that multiple classroom goals have interactive effects on students' personal achievement strivings. ©2010 The British Psychological Society.

  9. Aging characteristics of containment building and sensitivity on ultimate pressure capacity

    International Nuclear Information System (INIS)

    Seo, Jeong Moon; Choun, Young Sun; Choi, In Kil; Ha, Jae Joo


    For the reliable safety assessment of the containment building, structural and material conditions can be investigated in detail and pertinent assessment technologies have to be established. Also, an understanding on the aging-related degradations for the construction materials is required to predict long-term structural safety of the containment building. For the development of reliable aging prediction models, an extensive data base system related to aging properties of the containment building has to be prepared. The objectives of this research are to develop aging models representing long-term degradation of materials and a structural performance assessment program for containment building considering aging-related degradation. According to the results of sensitivity analysis, as the mechanical properties of the constituent materials degrade, the ultimate pressure capacity of containment building may decrease and severe damage may occur around the mid-level of the containment wall. (author). 28 refs., 11 tabs., 36 figs

  10. Ultimate Limit State Design Of Sheet Pile Walls By Finite Elements And Nonlinear Programming

    DEFF Research Database (Denmark)

    Krabbenhøft, Kristian; Damkilde, Lars; Krabbenhøft, Sven


    Limit analysis has been used for decades in civil and mechanical engineering practice as a means of analyzing structures of materials which with reasonable accuracy can be described as being rigid-perfectly plastic. Such materials include steel, concrete and soils. Traditionally, most attention has...... been given to the problem which consists of determining the ultimate magnitude of a given set of loads acting on a structure with a given geometry. This problem is relevant when determining e.g. the necessary extrusion pressure in metal forming problems, when evaluating the bearing capacity...... is the load intensity. In the paper we consider the latter of these problems with particular reference to the design of sheet pile walls....

  11. Patient dose rate: An ultimate limit for spatial and density resolution of scanning systems

    International Nuclear Information System (INIS)

    Kowalski, G.; Wagner, W.


    In X-ray scanning systems, picture quality of the reconstructed slices is limited to a maximum spatial as well as density resolution by the applied radiation dose. Density resolution can be improved in proportion to the root of the patient dose, whereas a doubled spatial resolving power requires an eight times higher patient dose, assuming a fixed slice thickness. Only a careful trade-off between the applied patient dose, density resolution and spatial resolution yields a maximal diagnostic value for the physician. Specifications of a scanning system have to take into account these ultimate restrictions, so that picture quality really is limited by the patient's dose rather than by technical constraints. In addition a method is given by which the applied dose can be reduced by focusing the main intensity onto the region of interest, in case that region is known a priori. (orig.) [de

  12. Methodological Challenges of Identifying Ultimate Land Use Changes Caused by Biofuel Production

    DEFF Research Database (Denmark)

    Wenzel, Henrik; Kløverpris, Jesper; Nielsen, Per Henning


    that is only poorly dealt with by LCA methods. Even though the use of land, or change of land cover and its eco-systems, is acknowledged to be a very important impact of human activities, a methodology for assessing this impact category has not yet  been properly developed within LCA. Some LCA scientists have...... looked into methods for assessing the impacts of given changes of land use, i.e. the impact assessment component of the LCA, but very few have looked into how to actually do the inventory modelling, i.e. how to identify which land is ultimately affected by the decision and system under study. State...... in the systems being studied. The aims of this paper is to analyse the mechanisms influencing the long-term land use consequences of changes in crop demand and propose a methodological framework for identifying these consequences within a global scope. The outset of the paper is the principles of consequential...

  13. An experimental investigation on the ultimate strength of epoxy repaired braced partial infilled RC frames (United States)

    Dubey, Shailendra Kumar Damodar; Kute, Sunil


    Due to earthquake, buildings are damaged partially or completely. Particularly structures with soft storey are mostly affected. In general, such damaged structures are repaired and reused. In this regard, an experimental investigation was planned and conducted on models of single-bay, single-storey of partial concrete infilled reinforced concrete (RC) frames up to collapse with corner, central and diagonal steel bracings. Such collapsed frames were repaired with epoxy resin and retested. The initiative was to identify the behaviour, extent of restored ultimate strength and deflection of epoxy-retrofitted frames in comparison to the braced RC frames. The performance of such frames has been considered only for lateral loads. In comparison to bare RC frames, epoxy repaired partial infilled frames have significant increase in the lateral load capacity. Central bracing is more effective than corner and diagonal bracing. For the same load, epoxy repaired frames have comparable deflection than similar braced frames.

  14. Silicon coupled-ring resonator structures for slow light applications: potential, impairments and ultimate limits

    International Nuclear Information System (INIS)

    Canciamilla, A; Torregiani, M; Ferrari, C; Morichetti, F; Melloni, A; De La Rue, R M; Samarelli, A; Sorel, M


    Coupled-ring resonator-based slow light structures are reported and discussed. By combining the advantages of high index contrast silicon-on-insulator technology with an efficient thermo-optical activation, they provide an on-chip solution with a bandwidth of up to 100 GHz and a slowdown factor of up to 16, as well as a continuous reconfiguration scheme and a fine tunability. The performance of these devices is investigated in detail for both static and dynamic operation, in order to evaluate their potential in optical signal processing applications at high bit rate. The main impairments imposed by fabrication imperfections are also discussed in relation to the slowdown factor. In particular, the analysis of the impact of backscatter, disorder and two-photon absorption on the device transfer function reveals the ultimate limits of these structures and provides valuable design rules for their optimization

  15. Process for extracting residual heat and device for the ultimate absorption of heat for nuclear reactors

    International Nuclear Information System (INIS)

    Bernard, Lawrence Jr.


    This invention concerns a 'heat sink' or device for the ultimate absorption of heat for electric power stations using the most widespread thermal neutron nuclear reactors, namely 'light water' reactors such as boiling or pressurized water reactors. The residual heat given off by these reactors can be safely extracted with this method by using dry cooling. However, the invention does not concern the problems arising from the cooling of the steam used for actuating the steam turbine nor the cooling of the steam exhausted by the turbine or coming from it, but it does concern the 'safety' part of the nuclear power station in which the residual heat discharged in the reactor is controlled and dissipated [fr

  16. Design proposal for ultimate shear strength of tapered steel plate girders

    Directory of Open Access Journals (Sweden)

    A. Bedynek


    Full Text Available Numerous experimental and numerical studies on prismatic plate girders subjected to shear can be found in the literature. However, the real structures are frequently designed as non-uniform structural elements. The main objective of the research is the development of a new proposal for the calculation of the ultimate shear resistance of tapered steel plate girders taking into account the specific behaviour of such members. A new mechanical model is presented in the paper and it is used to show the differences between the behaviour of uniform and tapered web panels subjected to shear. EN 1993-1-5 design specifications for the determination of the shear strength for rectangular plates are improved in order to assess the shear strength of tapered elements. Numerical studies carried out on tapered steel plate girders subjected to shear lead to confirm the suitability of the mechanical model and the proposed design expression.

  17. Determination of the ultimate load in concrete slabs by the yield line finite element method

    International Nuclear Information System (INIS)

    Vaz, L.E.; Feijo, B.; Martha, L.F.R.; Lopes, M.M.


    A method for calculating the ultimate load in reinforced concrete slabs is proposed. The method follows the finite element aproach representating the continuum slab as an assembly of rigid triangular plates connected along their sides through yield line elements. This approach leads to the definition of the displacement configuration of the plate only as a function of the transversal displacement at the nodes of the mesh (1 DOF per node) reducing significantly the number of DOF's in relation to the conventional formulation by means of the finite element method (minimum of 3 DOF per node). Nonlinear behaviour of the reinforced concrete section is considered in the definition of the moment rotation curve of the yield lines. The effect of the in plane forces acting in the middle surface of the plate is also taken into account. The validity of the model is verified comparing the numerical solutions with the results of the classical yield line theory. (Author) [pt

  18. Fuzzy stochastic analysis of serviceability and ultimate limit states of two-span pedestrian steel bridge (United States)

    Kala, Zdeněk; Sandovič, GiedrÄ--


    The paper deals with non-linear analysis of ultimate and serviceability limit states of two-span pedestrian steel bridge. The effects of random material and geometrical characteristics on limit states are analyzed. The Monte Carlo method was applied to stochastic analysis. For the serviceability limit state, also influence of fuzzy uncertainty of the limit deflection value on random characteristics of load capacity of variable action was studied. The results prove that, for the type of structure studied, the serviceability limit state is decisive from the point of view of design. The present paper opens a discussion on the use of stochastic analysis to verify the limit deflections given in the standards EUROCODES.

  19. Review of ultimate pressure capacity test of containment structure and scale model design techniques

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Jeong Moon; Choi, In Kil [Korea Atomic Energy Research Institute, Taejeon (Korea)


    This study was performed to obtain the basic knowledge of the scaled model test through the review of experimental studies conducted in foreign countries. The results of this study will be used for the wall segment test planed in next year. It was concluded from the previous studies that the larger the model, the greater the trust of the community in the obtained results. It is recommended that a scale model 1/4 - 1/6 be suitable considering the characteristics of concrete, reinforcement, liner and tendon. Such a large scale model test require large amounts of time and budget. Because of these reasons, it is concluded that the containment wall segment test with analytical studies is efficient for the verification of the ultimate pressure capacity of the containment structures. 57 refs., 46 figs., 11 tabs. (Author)

  20. Assessment of Wind Parameter Sensitivity on Ultimate and Fatigue Wind Turbine Loads: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Robertson, Amy N [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Sethuraman, Latha [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Jonkman, Jason [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Quick, Julian [National Renewable Energy Laboratory (NREL), Golden, CO (United States)


    Wind turbines are designed using a set of simulations to ascertain the structural loads that the turbine could encounter. While mean hub-height wind speed is considered to vary, other wind parameters such as turbulence spectra, sheer, veer, spatial coherence, and component correlation are fixed or conditional values that, in reality, could have different characteristics at different sites and have a significant effect on the resulting loads. This paper therefore seeks to assess the sensitivity of different wind parameters on the resulting ultimate and fatigue loads on the turbine during normal operational conditions. Eighteen different wind parameters are screened using an Elementary Effects approach with radial points. As expected, the results show a high sensitivity of the loads to the turbulence standard deviation in the primary wind direction, but the sensitivity to wind shear is often much greater. To a lesser extent, other wind parameters that drive loads include the coherence in the primary wind direction and veer.

  1. Ultimate Pressure Capacity of Prestressed Concrete Containment Vessels with Steel Fibers

    Energy Technology Data Exchange (ETDEWEB)

    Hahm, Dae Gi; Choun, Young Sun; Choi, In Kil [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)


    The ultimate pressure capacity (UPC) of the prestressed concrete containment vessel (PCCV) is very important since the PCCV are final protection to prevent the massive leakage of a radioactive contaminant caused by the severe accident of nuclear power plants (NPPs). The tensile behavior of a concrete is an important factor which influence to the UPC of PCCVs. Hence, nowadays, it is interested that the application of the steel fiber to the PCCVs since that the concrete with steel fiber shows an improved performance in the tensile behavior compared to reinforced concrete (RC). In this study, we performed the UPC analysis of PCCVs with steel fibers corresponding to the different volume ratio of fibers to verify the effectiveness of steel fibers on PCCVs

  2. La simplexité, ultime avatar de la complexité ?


    Demongeot, Jacques; Amor, Hedi Ben; Hazgui, Hana; Lontos, Athanasios


    1. Introduction La simplexité peut être considérée comme l’émergence de nouvelles fonctionnalités, issues des interactions entre sous-systèmes (ou modules) d’un système complexe : elle apparaît ainsi comme l’ultime avatar de la complexité, ce qui permet de la définir, sans rupture épistémologique avec le courant scientifique des systèmes complexes, comme la tendance qu’a la nature de sélectionner les fonctions vitales des êtres vivants, en particulier celles les plus utiles à la spécificité e...

  3. Assessing Fatigue and Ultimate Load Uncertainty in Floating Offshore Wind Turbines Due to Varying Simulation Length

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, G.; Lackner, M.; Haid, L.; Matha, D.; Jonkman, J.; Robertson, A.


    With the push towards siting wind turbines farther offshore due to higher wind quality and less visibility, floating offshore wind turbines, which can be located in deep water, are becoming an economically attractive option. The International Electrotechnical Commission's (IEC) 61400-3 design standard covers fixed-bottom offshore wind turbines, but there are a number of new research questions that need to be answered to modify these standards so that they are applicable to floating wind turbines. One issue is the appropriate simulation length needed for floating turbines. This paper will discuss the results from a study assessing the impact of simulation length on the ultimate and fatigue loads of the structure, and will address uncertainties associated with changing the simulation length for the analyzed floating platform. Recommendations of required simulation length based on load uncertainty will be made and compared to current simulation length requirements.

  4. Perception in the service of goal pursuit : Motivation to attain goals enhances the perceived size of goal instrumental objects.

    NARCIS (Netherlands)

    Veltkamp, M.; Aarts, H.; Custers, R.


    Two experiments tested the functional perception hypothesis (Bruner, 1957) according to which objects that are instrumental in attaining ones' goals are perceived to be bigger if one is motivated to attain these goals. Study 1 demonstrated that participants perceived a glass of water to be bigger

  5. Stapledon's Interplanetary Man: A Commonwealth of Worlds and the Ultimate Purpose of Space Colonisation (United States)

    Crawford, Ian A.

    In his 1948 lecture to the British Interplanetary Society Stapledon considered the ultimate purpose of colonising other worlds. Having examined the possible motivations arising from improved scientific knowledge and access to extraterrestrial raw materials, he concludes that the ultimate benefits of space colonisation will be the increased opportunities for developing human (and post-human) diversity, intellectual and aesthetic potential and, especially, `spirituality'. By the latter concept he meant a striving for ``sensitive and intelligent awareness of things in the universe (including persons), and of the universe as a whole.'' A key insight articulated by Stapledon in this lecture was that this should be the aspiration of all human development anyway, with or without space colonisation, but that the latter would greatly increase the scope for such developments. Another key aspect of his vision was the development of a diverse, but connected, `Commonwealth of Worlds' extending throughout the Solar System, and eventually beyond, within which human potential would be maximised. In this paper I analyse Stapledon's vision of space colonisation, and will conclude that his overall conclusions remain sound. However, I will also argue that he was overly utopian in believing that human social and political unity are prerequisites for space exploration (while agreeing that they are desirable objectives in their own right), and that he unnecessarily downplayed the more prosaic scientific and economic motivations which are likely to be key drivers for space exploration (if not colonisation) in the shorter term. Finally, I draw attention to some recent developments in international space policy which, although probably not influenced by Stapledon's work, are nevertheless congruent with his overarching philosophy as outlined in `Interplanetary Man?'.

  6. Ultimate internal pressure capacity of a reinforced concrete Mark III containment

    International Nuclear Information System (INIS)

    McGaughy, J.P. Jr.; Lin, F.T.; Sen, S.K.


    The static ultimate capacity of a Mark III BWR pressure suppression type containment has been investigated with a view to determine its capability to withstand the internal pressure associated with a postulated hydrogen burn. The reinforced concrete containment consists of a right circular cylinder covered by a hemispherical dome and supported on a flat circular foundation mat. A 1/4'' thick welded steel liner plate covers the inside surface of the containment shell. The cylinder is a 3.5 ft. thick shell with an inside radius of 62.0 feet. The thickness of the dome is 3.5 feet. Reinforcement in the shell is comprised of multi-layers of circumferential, meridional and diagonal rebars. Major containment penetrations consists of a circular equipment hatch and two personnel airlock assemblies. The containment ultimate capacity is determined by performing a non-linear analysis using the proprietary finite element computer code 'FINEL'. The code has the capability of modelling concrete cracking in tension and redistribution forces and moments to account for such phenomenon. For analysis purposes, the finite element model included the containment dome and the upper portion of the containment cylinder with appropriate boundary conditions applied at the model cut off region. This portion of the containment structure is selected because the segment of the cylinder that is included in the model has the least amount of hopp reinforcement, and when the general yield state is reached, the hoop reinforcement will be the limiting element. The containment structure has been treated as an axisymmetric shell using axisymmetric quadrilateral finite elements in the radial plane to model the liner plate and concrete. The reinforcing steel have been idealized by finite elements with unidirectional stiffness. (orig./RW)

  7. Ultimate refrigerating conditions, behavior turning and a thermodynamic analysis for absorption–compression hybrid refrigeration cycle

    International Nuclear Information System (INIS)

    Zheng Danxing; Meng Xuelin


    Highlights: ► Two novel fundamental concepts of the absorption refrigeration cycle were proposed. ► The interaction mechanism of compressor pressure increasing with other key-parameters was investigated. ► A set of optimal operating condition of hybrid refrigeration cycle was found. ► A simulation and investigation for R134a-DMF hybrid refrigeration cycle was performed. - Abstract: The absorption–compression hybrid refrigeration cycle has been considered as an effective approach to reduce the mechanical work consumption by using low-grade heat, such as solar energy. This work aims at studying the thermodynamic mechanism of the hybrid refrigeration cycle. Two fundamental concepts have been proposed, which are the ultimate refrigerating temperature (or the ultimate temperature lift) and the behavior turning. On the basis of that, the interaction mechanism of compressor pressure increasing with other key-parameters and the impact of compressor pressure increasing on the cycle performance have been investigated. The key-parameters include the concentration difference, the circulation ratio of working fluid, etc. The work points out that the hybrid refrigeration cycle performance varies with the change of compressor outlet pressure and depends on which one achieves dominance in the hybrid refrigeration cycle, the absorption sub-system or the compression sub-system. The behavior turning point during parameters changing corresponds to a maximum value of the heat powered coefficient of performance. In this case, the hybrid refrigeration cycle performance is optimal because the low-grade heat utilization is the most effective. In addition, to validate the theoretical analysis, a solar hybrid refrigeration cycle with R134a–DMF as working pair was simulated. The Peng–Robinson equation of state was adopted to calculate thermophysical properties when the reliability assessment of the prediction models on the available literature data of R134a–DMF system had been

  8. Goals and everyday problem solving: manipulating goal preferences in young and older adults. (United States)

    Hoppmann, Christiane A; Blanchard-Fields, Fredda


    In the present study, we examined the link between goal and problem-solving strategy preferences in 130 young and older adults using hypothetical family problem vignettes. At baseline, young adults preferred autonomy goals, whereas older adults preferred generative goals. Imagining an expanded future time perspective led older adults to show preferences for autonomy goals similar to those observed in young adults but did not eliminate age differences in generative goals. Autonomy goals were associated with more self-focused instrumental problem solving, whereas generative goals were related to more other-focused instrumental problem solving in the no-instruction and instruction conditions. Older adults were better at matching their strategies to their goals than young adults were. This suggests that older adults may become better at selecting their strategies in accordance with their goals. Our findings speak to a contextual approach to everyday problem solving by showing that goals are associated with the selection of problem-solving strategies.

  9. Antibody Engineering and Therapeutics (United States)

    Almagro, Juan Carlos; Gilliland, Gary L; Breden, Felix; Scott, Jamie K; Sok, Devin; Pauthner, Matthias; Reichert, Janice M; Helguera, Gustavo; Andrabi, Raiees; Mabry, Robert; Bléry, Mathieu; Voss, James E; Laurén, Juha; Abuqayyas, Lubna; Barghorn, Stefan; Ben-Jacob, Eshel; Crowe, James E; Huston, James S; Johnston, Stephen Albert; Krauland, Eric; Lund-Johansen, Fridtjof; Marasco, Wayne A; Parren, Paul WHI; Xu, Kai Y


    The 24th Antibody Engineering & Therapeutics meeting brought together a broad range of participants who were updated on the latest advances in antibody research and development. Organized by IBC Life Sciences, the gathering is the annual meeting of The Antibody Society, which serves as the scientific sponsor. Preconference workshops on 3D modeling and delineation of clonal lineages were featured, and the conference included sessions on a wide variety of topics relevant to researchers, including systems biology; antibody deep sequencing and repertoires; the effects of antibody gene variation and usage on antibody response; directed evolution; knowledge-based design; antibodies in a complex environment; polyreactive antibodies and polyspecificity; the interface between antibody therapy and cellular immunity in cancer; antibodies in cardiometabolic medicine; antibody pharmacokinetics, distribution and off-target toxicity; optimizing antibody formats for immunotherapy; polyclonals, oligoclonals and bispecifics; antibody discovery platforms; and antibody-drug conjugates. PMID:24589717

  10. Therapeutic and diagnostic nanomaterials

    CERN Document Server

    Devasena T


    This brief highlights nanoparticles used in the diagnosis and treatment of prominent diseases and toxic conditions. Ecofriendly methods which are ideal for the synthesis of medicinally valued nanoparticles are explained and the characteristic features of these particles projected. The role of these particles in the therapeutic field, and the induced biological changes in some diseases are discussed. The main focus is on inflammation, oxidative stress and cellular membrane integrity alterations. The effect of nanoparticles on these changes produced by various agents are highlighted using in vitro and in vivo models. The mechanism of nanoparticles in ameliorating the biological changes is supported by relevant images and data. Finally, the brief demonstrates recent developments on the use of nanoparticles in diagnosis or sensing of some biological materials and biologically hazardous environmental materials.

  11. [Therapeutic education didactic techniques]. (United States)

    Valverde, Maite; Vidal, Mercè; Jansa, Margarida


    This article includes an introduction to the role of Therapeutic Education for Diabetes treatment according to the recommendations of the American Diabetes Association (ADA), the Diabetes Education Study Group (DESG) of the "European Association for Study of Diabetes (EASD) and the clinical Practice Guidelines (CPG) of the Spanish Ministry of Health. We analyze theoretical models and the differences between teaching vs. learning as well as current trends (including Internet), that can facilitate meaningful learning of people with diabetes and their families and relatives. We analyze the differences, similarities, advantages and disadvantages of individual and group education. Finally, we describe different educational techniques (metaplan, case method, brainstorming, role playing, games, seminars, autobiography, forums, chats,..) applicable to individual, group or virtual education and its application depending on the learning objective.

  12. Therapeutic strategies in pulmonary hypertension

    Directory of Open Access Journals (Sweden)

    Leonello eFuso


    Full Text Available Pulmonary hypertension (PH is a life-threatening condition characterized by elevated pulmonary arterial pressure. It is clinically classified into five groups: patients in the first group are considered to have pulmonary arterial hypertension (PAH whereas patients of the other groups have PH that is due to cardiopulmonary or other systemic diseases. The management of patients with PH has advanced rapidly over the last decade and the introduction of specific treatments especially for PAH has lead to an improved outcome. However, despite the progress in the treatment, the functional limitation and the survival of these patients remain unsatisfactory and there is no cure for PAH. Therefore the search for an ideal therapy still goes on. At present, two levels of treatment can be identified: primary and specific therapy. Primary therapy is directed at the underlying cause of the PH. It also includes a supportive therapy consisting in oxygen supplementation, diuretics, and anticoagulation which should be considered in all patients with PH. Specific therapy is directed at the PH itself and includes treatment with vasodilatators such as calcium channel blockers and with vasodilatator and pathogenetic drugs such as prostanoids, endothelin receptor antagonists and phosphodiesterase type-5 inhibitors. These drugs act in several pathogenetic mechanisms of the PH and are specific for PAH although they might be used also in the other groups of PH. Finally, atrial septostomy and lung transplantation are reserved for patients refractory to medical therapy. Different therapeutic approaches can be considered in the management of patients with PH. Therapy can be established on the basis of both the clinical classification and the functional class. It is also possible to adopt a goal-oriented therapy in which the timing of treatment escalation is determined by inadequate response to known prognostic indicators.

  13. Multiple goals, motivation and academic learning. (United States)

    Valle, Antonio; Cabanach, Ramón G; Núnez, José C; González-Pienda, Julio; Rodríguez, Susana; Piñeiro, Isabel


    The type of academic goals pursued by students is one of the most important variables in motivational research in educational contexts. Although motivational theory and research have emphasised the somewhat exclusive nature of two types of goal orientation (learning goals versus performance goals), some studies (Meece, 1994; Seifert, 1995, 1996) have shown that the two kinds of goals are relatively complementary and that it is possible for students to have multiple goals simultaneously, which guarantees some flexibility to adapt more efficaciously to various contexts and learning situations. The principal aim of this study is to determine the academic goals pursued by university students and to analyse the differences in several very significant variables related to motivation and academic learning. Participants were 609 university students (74% women and 26% men) who filled in several questionnaires about the variables under study. We used cluster analysis ('quick cluster analysis' method) to establish the different groups or clusters of individuals as a function of the three types of goals (learning goals, performance goals, and social reinforcement goals). By means of MANOVA, we determined whether the groups or clusters identified were significantly different in the variables that are relevant to motivation and academic learning. Lastly, we performed ANOVA on the variables that revealed significant effects in the previous analysis. Using cluster analysis, three groups of students with different motivational orientations were identified: a group with predominance of performance goals (Group PG: n = 230), a group with predominance of multiple goals (Group MG: n = 238), and a group with predominance of learning goals (Group LG: n = 141). Groups MG and LG attributed their success more to ability, they had higher perceived ability, they took task characteristics into account when planning which strategies to use in the learning process, they showed higher persistence

  14. Consumer Buying Goals and Communication Behavior. (United States)

    Moore, Roy L.; Moschis, George P.

    Four hundred eight female users of cosmetics in Madison, Wisconsin, responded to questionnaires which sought to discover correlations among the goal of the purchaser and the type and source of information sought in the buying decision. Two goals were identified: rational (cost, functional benefits of product, or possible undesirable consequences…

  15. 33 CFR 385.38 - Interim goals. (United States)


    ..., monitoring and assessment; (ii) Be provided to the independent scientific review panel established in.... The interim goals shall be developed through the use of appropriate models and tools and shall provide... to be required to meet long-term hydrological and ecological restoration goals, based on best...

  16. Management Matters: Planning Goals and Time (United States)

    Pappas, Marjorie L.


    This article discusses the importance of setting and implementing goals that can help change and improve a library media program over time--goals that go beyond merely keeping the library media center running. Suggestions for developing an action plan and strategies for effective time management are also presented.

  17. Maternal death and the Millennium Development Goals

    DEFF Research Database (Denmark)

    Rasch, Vibeke


    Maternal health is one of the main global health challenges and reduction of the maternal mortality ratio, from the present 0.6 mio. per year, by three-quarters by 2015 is the target for the fifth Millennium Development Goal (MDG 5). However this goal is the one towards which the least progress h...

  18. Comparing the achievement goal orientation of mathematics ...

    African Journals Online (AJOL)

    Comparing the achievement goal orientation of mathematics learners with and without attention-deficit hyperactivity disorder. ... in recognising methods to direct learners' goals for better engagement with and improved results in mathematics, which could support learners to develop to their full potential in the subject.

  19. Cattle breeding goals and production circumstances

    NARCIS (Netherlands)

    Groen, A.F.


    This thesis gives the results of a study on the relationship between cattle breeding goals and production circumstances. The relationship between breeding goals and production circumstances mostly arises from the influences of production circumstances on the economic values of

  20. Comparing the achievement goal orientation of mathematics ...

    African Journals Online (AJOL)

    A quantitative, exploratory research design was used. ... Goals affect how learners approach mathematics learning activities, which could ... research on academic success and ADHD has focused on reading ... from the data analysis process. ... Achievement goal orientation is based on a ...... Research design: Qualitative,.

  1. GOAL-to-HAL translation study (United States)

    Flanders, J. H.; Helmers, C. T.; Stanten, S. F.


    This report deals with the feasibility, problems, solutions, and mapping of a GOAL language to HAL language translator. Ground Operations Aerospace Language, or GOAL, is a test-oriented higher order language developed by the John F. Kennedy Space Center to be used in checkout and launch of the space shuttle. HAL is a structured higher order language developed by the Johnson Space Center to be used in writing the flight software for the onboard shuttle computers. Since the onboard computers will extensively support ground checkout of the space shuttle, and since these computers and the software development facilities on the ground use the HAL language as baseline, the translation of GOAL to HAL becomes significant. The issue of feasibility was examined and it was found that a GOAL to HAL translator is feasible. Special problems are identified and solutions proposed. Finally, examples of translation are provided for each category of complete GOAL statement.

  2. Constellation Stretch Goals: Review of Industry Inputs (United States)

    Lang, John


    Many good ideas received based on industry experience: a) Shuttle operations; b) Commercial aircraft production; c) NASA's historical way of doing business; d) Military and commercial programs. Aerospace performed preliminary analysis: a) Potential savings; b) Cost of implementation; c) Performance or other impact/penalties; d) Roadblocks; e) Unintended consequences; f) Bottom line. Significant work ahead for a "Stretch Goal"to become a good, documented requirement: 1) As a group, the relative "value" of goals are uneven; 2) Focused analysis on each goal is required: a) Need to ensure that a new requirement produces the desired consequence; b) It is not certain that some goals will not create problems elsewhere. 3) Individual implementation path needs to be studied: a) Best place to insert requirement (what level, which document); b) Appropriate wording for the requirement. Many goals reflect "best practices" based on lessons learned and may have value beyond near-term CxP requirements process.

  3. The neuroanatomist's dream, the problems and solutions, and the ultimate aim


    Felipe, Javier de


    The principal goal in neuroanatomy is to define the detailed structural design of the nervous system. This challenge is one of the first steps towards understanding how neural circuits contribute to the functional organization of the nervous system, both in health and disease. The main difficulties involve unraveling the extraordinary complexity of the nervous system and to define how information flows through this finely organized synaptic network. Over the years, neuroanatomy has evolved co...

  4. Achievement goals, social goals, and motivational regulations in physical education settings. (United States)

    Cecchini Estrada, José A; González González-Mesa, Carmen; Méndez-Giménez, Antonio; Fernández-Río, Javier


    This study examined the relationship between achievement and social goals, and explored how both goals affect students' level of informed self-determination in Physical Education. Participants were 395 high school students. Three scales were used to assess achievement, social goals, and motivation. Several hierarchical regression analyses revealed that mastery-approach goals were the greatest contributors to the individuals' levels of self-determination. Achievement and social goals were found to be separate predictors of students' levels of self-determination, and this highlights the importance of separating mastery and performance goals into avoidance and approach profiles. Girls reported significantly higher values than boys on responsibility, relationship, and mastery-avoidance goals, whereas boys scored higher on performance-approach goals. Researchers could use achievement and social goals to study students' motivation and achievement in Physical Education settings.

  5. [Perceptions of classroom goal structures, personal achievement goal orientations, and learning strategies]. (United States)

    Miki, Kaori; Yamauchi, Hirotsugu


    We examined the relations among students' perceptions of classroom goal structures (mastery and performance goal structures), students' achievement goal orientations (mastery, performance, and work-avoidance goals), and learning strategies (deep processing, surface processing and self-handicapping strategies). Participants were 323 5th and 6th grade students in elementary schools. The results from structural equation modeling indicated that perceptions of classroom mastery goal structures were associated with students' mastery goal orientations, which were in turn related positively to the deep processing strategies and academic achievement. Perceptions of classroom performance goal stractures proved associated with work avoidance-goal orientations, which were positively related to the surface processing and self-handicapping strategies. Two types of goal structures had a positive relation with students' performance goal orientations, which had significant positive effects on academic achievement. The results of this study suggest that elementary school students' perceptions of mastery goal structures are related to adaptive patterns of learning more than perceptions of performance goal structures are. The role of perceptions of classroom goal structure in promoting students' goal orientations and learning strategies is discussed.

  6. Key components of effective collaborative goal setting in the chronic care encounter. (United States)

    Bigi, Sarah


    Collaborative goal setting in patient-provider communication with chronic patients is the phase in which--after collecting the data regarding the patient's health--it is necessary to make a decision regarding the best therapy and behaviors the patient should adopt until the next encounter. Although it is considered a pivotal phase of shared decision making, there remain a few open questions regarding its components and its efficacy: What are the factors that improve or impede agreement on treatment goals and strategies?; What are the 'success conditions' of collaborative goal setting?; How can physicians effectively help patients make their preferences explicit and then co-construct with them informed preferences to help them reach their therapeutic goals? Using the theoretical framework of dialogue types, an approach developed in the field of Argumentation Theory, it will be possible to formulate hypotheses on the success conditions' and effects on patient commitment of collaborative goal setting.

  7. Treatment of the loss of ultimate heat sink initiating events in the IRSN level 1 PSA

    International Nuclear Information System (INIS)

    Dupuy, Patricia; Georgescu, Gabriel; Corenwinder, Francois


    The total loss of the ultimate heat sink is an initiating event which, even it is mainly of external origin, has been considered in the frame of internal events Level 1 PSA by IRSN. The on-going actions on the development of external hazards PSA and the recent incident of loss of the heat sink induced by the ingress of vegetable matter that occurred in France in 2009 have pointed out the need to improve the modeling of the loss of the heat sink initiating event and sequences to better take into account the fact that this loss may be induced by external hazards and thus affect all the site units. The paper presents the historical steps of the modeling of the total loss of the heat sink, the safety stakes of this modeling, the main assumptions used by IRSN in the associated PSA for the 900 MWe reactors and the results obtained. The total loss of the heat sink was not initially addressed in the safety demonstration of French NPPs. On the basis of the insights of the first probabilistic assessments performed in the 80's, the risks associated to this 'multiple failure situation' turned out to be very significant and design and organisational improvements were implemented on the plants. Reviews of the characterization of external hazards and of their consequences on the installations and French operating feedback have revealed that extreme hazards may induce a total loss of the heat sink. Moreover, the accident that occurred at Fukushima in 2011 has pointed out the risk of such a loss of long duration at all site units in case of extreme hazards. In this context, it seems relevant to further improve the modelling of the total loss of the heat sink by considering the external hazards that may cause this loss. In a first step, IRSN has improved the assumptions and data used in the loss of the heat sink PSA model, in particular by considering that such a loss may affect all the site units. The next challenge will be the deeper analysis of the impact of external hazards on

  8. NEOCE: a new external occulting coronagraph experiment for ultimate observations of the chromosphere, corona and interface (United States)

    Damé, Luc; Fineschi, Silvano; Kuzin, Sergey; Von Fay-Siebenburgen, Erdélyi Robert

    Several ground facilities and space missions are currently dedicated to the study of the Sun at high resolution and of the solar corona in particular. However, and despite significant progress with the advent of space missions and UV, EUV and XUV direct observations of the hot chromosphere and million-degrees coronal plasma, much is yet to be achieved in the understanding of these high temperatures, fine dynamic dissipative structures and of the coronal heating in general. Recent missions have shown the definite role of a wide range of waves and of the magnetic field deep in the inner corona, at the chromosphere-corona interface, where dramatic and physically fundamental changes occur. The dynamics of the chromosphere and corona is controlled and governed by the emerging magnetic field. Accordingly, the direct measurement of the chromospheric and coronal magnetic fields is of prime importance. The solar corona consists of many localised loop-like structures or threads with the plasmas brightening and fading independently. The plasma evolution in each thread is believed to be related to the formation of filaments, each one being dynamic, in a non-equilibrium state. The mechanism sustaining this dynamics, oscillations or waves (Alfvén or other magneto-plasma waves), requires both very high-cadence, multi-spectral observations, and high resolution and coronal magnetometry. This is foreseen in the future Space Mission NEOCE (New External Occulting Coronagraph Experiment), the ultimate new generation high-resolution coronagraphic heliospheric mission, to be proposed for ESA M4. NEOCE, an evolution of the HiRISE mission, is ideally placed at the L5 Lagrangian point (for a better follow-up of CMEs), and provides FUV imaging and spectro-imaging, EUV and XUV imaging and spectroscopy, and ultimate coronagraphy by a remote external occulter (two satellites in formation flying 375 m apart minimizing scattered light) allowing to characterize temperature, densities and

  9. Kansas Department of Transportation column expert : ultimate shear capacity of circular columns using the simplified modified compression field theory. (United States)


    The importance of the analysis of circular columns to accurately predict their ultimate confined : capacity under shear-flexure-axial force interaction domain is recognized in light of the extreme load event : imposed by the current American Associat...

  10. Millennium development goals: Examining Kenya constraints in achieving the eight goals

    Directory of Open Access Journals (Sweden)

    Wambua Leonard Munyao


    Full Text Available This paper examines Kenya’s performance in achieving the famous millennium development goals. The paper provides the government and other stakeholders with proper understanding of the constraints of achieving the millennium development goals as well as reflecting the phase and the passion of the country in achieving this important development goal. The paper further seeks to stress the importance of this goal in reducing poverty in the country. The paper has cited some key factors undermining achieving of the millennium development goals in Kenya. Major recommendations that can contribute towards achieving of the millennium development goals have also been made.

  11. [Nuclear transfer and therapeutic cloning]. (United States)

    Xu, Xiao-Ming; Lei, An-Min; Hua, Jin-Lian; Dou, Zhong-Ying


    Nuclear transfer and therapeutic cloning have widespread and attractive prospects in animal agriculture and biomedical applications. We reviewed that the quality of oocytes and nuclear reprogramming of somatic donor cells were the main reasons of the common abnormalities in cloned animals and the low efficiency of cloning and showed the problems and outlets in therapeutic cloning, such as some basic problems in nuclear transfer affected clinical applications of therapeutic cloning. Study on isolation and culture of nuclear transfer embryonic stem (ntES) cells and specific differentiation of ntES cells into important functional cells should be emphasized and could enhance the efficiency. Adult stem cells could help to cure some great diseases, but could not replace therapeutic cloning. Ethics also impeded the development of therapeutic cloning. It is necessary to improve many techniques and reinforce the research of some basic theories, then somatic nuclear transfer and therapeutic cloning may apply to agriculture reproduction and benefit to human life better.

  12. Molecularly targeted therapeutic radiopharmaceuticals

    International Nuclear Information System (INIS)

    Saw, M.M.


    Full text: It is generally agreed that current focus of nuclear medicine development should be on molecular imaging and therapy. Though, the widespread use of the terminology 'molecular imaging' is quite recent, nuclear medicine has used molecular imaging techniques for more than 20 years ago. A variety of radiopharmaceuticals have been introduced for the internal therapy of malignant and inflammatory lesions in nuclear medicine. In the field of bio/medical imaging, nuclear medicine is one of the disciplines which has the privilege of organized and well developed chemistry/ pharmacy section; radio-chemistry/radiopharmacy. Fundamental principles have been developed more than 40 years ago and advanced research is going well into postgenomic era. The genomic revolution and dramatically increased insight in the molecular mechanisms underlying pathology have led to paradigm shift in drug development. Likewise does in the nuclear medicine. Here, the author will present current clinical and pre-clinical therapeutic radiopharmaceuticals based on molecular targets such as membrane-bound receptors, enzymes, nucleic acids, sodium iodide symporter, etc, in correlation with fundamentals of radiopharmacy. (author)

  13. A probabilistics safety assessment of ultimate response guidelines of Maanshan Nuclear Power Plant

    Energy Technology Data Exchange (ETDEWEB)

    Wang, P-Y.; Lee, M. [National Tsing Hua Univ., Hsinchu, Taiwan (China); Chao, C-C. [Inst. of Nuclear Energy Research, Taoyuan, Taiwan (China)


    Ultimate Response Guidelines (URGs) was proposed to mitigate the so called 'Fukushima type accident' of nuclear power plants (NPPs). As specified in URGs, if it is necessary, operators will depressurize the secondary side of steam generators (SGs) to bring in the low pressure water. The injection damages the economic value of the plant. However, the injection prevents the cladding temperature from rising above 1500 F (1089 K), which is the temperature that release of volatile fission products from gap is initiated. In the present study, the impact of URGs on the Core Damage Frequency (CDF) in a SBO (Station Blackout) accident of a Pressurized Water Reactor (PWR) designed by Westinghouse and adopts large dry containment is quantified. In the Base Case analysis of the study, the actions in the URGs are not considered. The CDF of SBO in the base case calculation is 2.49x10{sup -7} year. The actions specified in URGs can reduce CDF by 62%. The strategies in URGs are very effective in enhancing the reliability of decay heat removal via SG secondary side. Therefore, the implementation of these strategies can reduce the CDF of sequences involving late failure of AFWS. After the incorporation URGs, the dominant sequences of SBO are the sequences with seal failure. (author)

  14. Ultimate pressure capacity assessment of R FRC PCCV based on the tension stiffening tests

    International Nuclear Information System (INIS)

    Hahm, Dae Gi; Choun, Young Sun


    The use of fibers in concrete or cement composites can enhance the performance of structural elements. Fibers have been used for a cement mixture to increase the toughness and tensile strength, and to improve the cracking and deformation characteristics. The addition of fibers into concrete can improve the ductility and increase the tensile resistance of concrete structures. Recently, the application of fibers to prestressed concrete containment vessels (PCCVs) has been a major research topic. However, the tensile stiffening behavior of reinforced - fiber reinforced concrete (RFRC) is not fully developed yet especially for specimens using large diameter re bars. In nuclear power plant (NPP) PCCVs, large diameter re bars are applied. Therefore, the tensile stiffening behavior model should be developed to assess ultimate pressure capacity (UPC) of R FRC PCCVs. In this study, we modeled the tensile stiffening behavior of R FRC PCCVs by using recently developed model, and assessed the UPC of R FRC PCCVs. To do this, we performed tension stiffening test of R FRC with large diameter re bar

  15. Ultimate disposal of radioactive waste in the FRG - current progress of projects and perspectives

    International Nuclear Information System (INIS)

    Roesel, H.


    In the Federal Republic of Germany, the state is responsible for providing for the ultimate disposal of radioactive waste, whereas the cost is borne by the waste producing establishments. The Federal Ministry for the Environment, Nature Conservation and Reactor Safety, (BMU), as the competent state authority has delegated its responsibilities in this matter to the Physikalisch-Technische Bundesanstalt (PTB). The PTB is allowed to have work done by third parties. For this purpose, the Deutsche Gesellschaft zum Bau und Betrieb von Endlagern fuer Abfallstoffe mbH (DBE) has been founded, which since 1979 is investigating the Gorleben salt dome for suitability to serve as a repository for all type of solid, radioactive waste. The final decisions on site approval can be taken after completion of the underground exploration work, which according to current schedules is expected to be achieved at the end of the 1990s. The other candidate site, the Konrad mine, has been investigated by the GSF in the years 1976 to 1982, and on August 31, 1982 the PTB has filed an application to institute the plan approval procedure for the Konrad mine to be prepared to serve as a waste repository. The plan is expected to be laid open in the first half of 1989, and hearings possibly be held in the second half. In case of plan approval, the site preparation will probably take 3 years, so that the Konrad mine will be ready to receive radioactive waste by the year 1993. (orig.) [de

  16. An Experimental Investigation on the Ultimate Strength of Partially Infilled: Braced Steel Frames (United States)

    Dubey, Shailendra Kumar Damodar; Kute, Sunil Y.


    Infilled walls are usually, considered as non-structural elements. However, these walls are effective in carrying lateral loads. In this regard, an experimental investigation was planned and conducted to study the effect of braced and partially infilled steel frames with cement mortar and concrete in comparison to the bare frames. All these frames were tested up to collapse and subjected only to horizontal loads to obtain an effective and possible solution for soft storey which are generally not infilled. In comparison to bare steel frames, partially infilled frames have an increase of lateral load capacity by 45-60%. Central bracing is more effective than that of the corner bracing. For the same load partially infilled frames have significantly less deflection than that of the bare frames. A reduced load factor is suggested for the design of soft storey columns with the partial infills. A mathematical model has been proposed to calculate the theoretical ultimate load for the braced, cement mortar and concrete partial infilled frames.

  17. Hierarchical nanoporous metals as a path toward the ultimate three-dimensional functionality. (United States)

    Fujita, Takeshi


    Nanoporous metals prepared via dealloying or selective leaching of solid solution alloys and compounds represent an emerging class of materials. They possess a three-dimensional (3D) structure of randomly interpenetrating ligaments/nanopores with sizes between 5 nm and several tens of micrometers, which can be tuned by varying their preparation conditions (such as dealloying time and temperature) or additional thermal coarsening. As compared to other nanostructured materials, nanoporous metals have many advantages, including their bicontinuous structure, tunable pore sizes, bulk form, good electrical conductivity, and high structural stability. Therefore, nanoporous metals represent ideal 3D materials with versatile functionality, which can be utilized in various fields. In this review, we describe the recent applications of nanoporous metals in molecular detection, catalysis, 3D graphene synthesis, hierarchical pore formation, and additive manufacturing (3D printing) together with our own achievements in these areas. Finally, we discuss possible ways of realizing the ultimate 3D functionality beyond the scope of nanoporous metals.


    Delcourt, Johann; Bode, Nikolai W F; Denoël, Mathieu


    Ant mill, caterpillar circle, bat doughnut, amphibian vortex, duck swirl, and fish torus are different names for rotating circular animal formations, where individuals turn around a common center. These "collective vortex behaviors" occur at different group sizes from pairs to several million individuals and have been reported in a large number of organisms, from bacteria to vertebrates, including humans. However, to date, no comprehensive review and synthesis of the literature on vortex behaviors has been conducted. Here, we review the state of the art of the proximate and ultimate causes of vortex behaviors. The ubiquity of this behavioral phenomenon could suggest common causes or fundamental underlying principles across contexts. However, we find that a variety of proximate mechanisms give rise to vortex behaviors. We highlight the potential benefits of collective vortex behaviors to individuals involved in them. For example, in some species, vortices increase feeding efficiency and could give protection against predators. It has also been argued that vortices could improve collective decision-making and information transfer. We highlight gaps in our understanding of these ubiquitous behavioral phenomena and discuss future directions for research in vortex studies.

  19. Ultimate intra-wafer critical dimension uniformity control by using lithography and etch tool corrections (United States)

    Kubis, Michael; Wise, Rich; Reijnen, Liesbeth; Viatkina, Katja; Jaenen, Patrick; Luca, Melisa; Mernier, Guillaume; Chahine, Charlotte; Hellin, David; Kam, Benjamin; Sobieski, Daniel; Vertommen, Johan; Mulkens, Jan; Dusa, Mircea; Dixit, Girish; Shamma, Nader; Leray, Philippe


    With shrinking design rules, the overall patterning requirements are getting aggressively tighter. For the 7-nm node and below, allowable CD uniformity variations are entering the Angstrom region (ref [1]). Optimizing inter- and intra-field CD uniformity of the final pattern requires a holistic tuning of all process steps. In previous work, CD control with either litho cluster or etch tool corrections has been discussed. Today, we present a holistic CD control approach, combining the correction capability of the etch tool with the correction capability of the exposure tool. The study is done on 10-nm logic node wafers, processed with a test vehicle stack patterning sequence. We include wafer-to-wafer and lot-to-lot variation and apply optical scatterometry to characterize the fingerprints. Making use of all available correction capabilities (lithography and etch), we investigated single application of exposure tool corrections and of etch tool corrections as well as combinations of both to reach the lowest CD uniformity. Results of the final pattern uniformity based on single and combined corrections are shown. We conclude on the application of this holistic lithography and etch optimization to 7nm High-Volume manufacturing, paving the way to ultimate within-wafer CD uniformity control.

  20. Measurement of ultimate tensile strength and Young modulus in LYSO scintillating crystals

    Energy Technology Data Exchange (ETDEWEB)

    Scalise, Lorenzo, E-mail: [Dipartimento di Meccanica, Universita Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona (Italy); Rinaldi, Daniele [Dipartimento di Fisica e Ingegneria dei Materiali e del Territorio, Universita Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona (Italy); Istituto Nazionale di Fisica Nucleare, Section of Perugia (Italy); Davi, Fabrizio [Dipartimento di Architettura Costruzioni e Strutture, Universita Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona (Italy); Paone, Nicola [Dipartimento di Meccanica, Universita Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona (Italy)


    Scintillating crystals are employed in high energy physics, in medical imaging, diagnostic and security. Two mechanical properties of lutetium-yttrium oxyorthosilicate cerium-doped Lu{sub 2(1-x)}Y{sub 2x}SiO{sub 5}:Ce with x=0.1 (LYSO) crystals have been measured: the ultimate tensile stress ({sigma}{sub UTS}) and the Young elastic modulus (E). Measurements are made by means of a 4-points loading device and the experimental results account for an elastic-brittle stress-strain relation, which depends heavily on the specimen preparation and the material defects. {sigma}{sub UTS} along the [0 1 0] tensile direction ranges within 68.14 and 115.61 MPa, which, in the lowest case, is more than twice with respect to those measured for PbWO{sub 4} (PWO), exhibiting a marked difference between the annealed and the not-annealed samples. The mean elastic modulus (E), along the same direction, is E=1.80x10{sup 11} ({+-}2.15x10{sup 10}) N/m{sup 2}, with lower dispersion respect to UTS data. This type of analysis and study can be included into quality control procedures of crystals, based on samples taken out of production; such procedures can be established for industrial processing of crystals aimed to the high energy physics (calorimeters) and medical imaging (PET, etc.) applications.

  1. PEP-X: An Ultimate Storage Ring Based on Fourth-Order Geometric Achromats

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Yunhai; Bane, Karl; Hettel, Robert; Nosochkov, Yuri; Wang, Min-Huey; /SLAC


    We have designed an 'ultimate' storage ring for the PEP-X light source that achieves the diffraction limited emittances (at 1.5 {angstrom}) of 12 pm-rad in both horizontal and vertical planes with a 4.5-GeV beam. These emittances include the contribution of intrabeam scattering at a nominal current of 200 mA in 3300 bunches. This quality beam in conjunction with a conventional 4-m undulator in a straight section can generate synchrotron radiation having a spectral brightness above 10{sup 22} [photons/s/mm{sup 2}/mrad{sup 2}/0.1% BW] at a 10 keV photon energy. The high coherence at the diffraction limit makes PEP-X competitive with 4th generation light sources based on an energy recovery linac. In addition, the beam lifetime is several hours and the dynamic aperture is large enough to allow off-axis injection. The alignment and stability tolerances, though challenging, are achievable. A ring with all these properties is only possible because of several major advances in mitigating the effects of nonlinear resonances.

  2. A new approach to the modeling of ultimate heat sink cooling ponds

    International Nuclear Information System (INIS)

    Policastro, A.J.; Wastag, M.; Paul, J.; Carhart, R.A.


    Ultimate heat sink (UHS) cooling pond thermal performance is analyzed by a new method in which zero, one, and three-dimensional models are used in combination. A typical UHS pond has an irregular shape covering 20 hectares at an average depth of 4 m with a heavy thermal load of 40 MWt (megawatts thermal) per hectare. The resulting flow field can be one, two or three dimensional. A three-dimensional numerical model (Paul 1983) is modified and used to determine the effective dimensionality of the pond under accident conditions. The model's surface heat transfer formulas and its predictions of thermal hydraulics are verified using laboratory and field data. The Paul model shows that, unlike normal cooling ponds, a typical UHS pond is vertically-mixed with only a longitudinal temperature variation. Buoyancy-driven circulations, strong discharge-to-intake flow, and rapid surface heat removal break down the usual vertical stratification. Predictions of the one-dimensional MITEMP model are shown to agree with Paul model predictions for a typical UHS pond at the Catawba Nuclear Power Plant

  3. Test research and analysis for ultimate capacity of Qinshan NPP PCCV

    International Nuclear Information System (INIS)

    Zufeng, X.


    This paper introduces design and research for containment of Qinshan NPP which is the first PWR in CHINA designed and constructed by ourselves. The PCCV design is basically in conformity to ASME code. To verify the structural integrity capacity of Qinshan NPP containment, we fulfilled SIT and ILRT successfully in June, 1991. The special attention of the paper is focused on the ultimate capacity of the PCCV under severe accidents and earthquake. A study comprised of five different independent parts has been performed for the development of containment model test and corresponding nonlinear analysis. There are two prestressed concrete containment models with equipment hatch. One is 1/15 scale with steel liner tested on shake table and then moved out loaded with atmospheric pressure. The other is 1/10 scale without steel liner loaded with water pressure until destruction. From different methods including model test and nonlinear analysis, all obtained unanimous conclusion. The capacity under internal pressure and earthquake is reliable. The safety margin is enough. Consequently, in the second phase of Qinshan NPP and other PWR NPP under design, PCCV should be a better selection in China since it's more economic, rational and safe. (author)

  4. Ultimate methane yield from beef cattle manure: effect of temperature, ration constituents, antibiotics and manure age

    Energy Technology Data Exchange (ETDEWEB)

    Hashimoto, A G; Varel, V H; Chen, Y R


    The effects of temperature, ration constituents, antibiotics and manure age on the ultimate methane yield (Bo, litre CH4/g volatile solids fed (VSf)) were investigated using 4-litre batch fermenters. The average Bo for fermenters maintained at 30-60 degrees Celcius (at 5 degrees Celcius intervals) was 0.328 litre CH4/g VSf. The Bo at 65 degrees Celcius averaged 0.118 litre CH4g VSf, but this low yield was attributed to unstable fermentation rather than decreased substrate availability at that temperature. These results agreed well with Bo values estimated from daily-fed fermenters. Chlortetracycline and monensin did not affect Bo; however, monensin did delay the start of active fermentation in batch fermenters. The average Bo of manure from cattle fed 91.5, 40 and 7% corn silage were 0.173, 0.232 and 0.290 litre CH4/g VSf, respectively. The average Bo for 6-8 week old manure from a dirt feedlot was 0.210 litre CH4/g VSf. (Refs. 14).

  5. Ultimate disposition of aluminum clad spent nuclear fuel in the United States

    International Nuclear Information System (INIS)

    Messick, C.E.; Clark, W.D.; Clapper, M.; Mustin, T.P.


    Treatment and disposition of spent nuclear fuel (SNF) in the United States has changed significantly over the last decade due to change in world climate associated with nuclear material. Chemical processing of aluminum based SNF is ending and alternate disposition paths are being developed that will allow for the ultimate disposition of the enriched uranium in this SNF. Existing inventories of aluminum based SNF are currently being stored primarily in water-filled basins at the Savannah River Site (SRS) while these alternate disposition paths are being developed and implemented. Nuclear nonproliferation continues to be a worldwide concern and it is causing a significant influence on the development of management alternatives for SNF. SRS recently completed an environmental impact statement for the management of aluminum clad SNF that selects alternatives for all of the fuels in inventory. The U.S. Department of Energy and SRS are now implementing a dual strategy of processing small quantities of 'problematic' SNF while developing an alternative technology to dispose of the remaining aluminum clad SNF in the proposed monitored geologic repository. (author)

  6. Structural Phenomenon of Cement-Based Composite Elements in Ultimate Limit State

    Directory of Open Access Journals (Sweden)

    I. Iskhakov


    Full Text Available Cement-based composite materials have minimum of two components, one of which has higher strength compared to the other. Such materials include concrete, reinforced concrete (RC, and ferrocement, applied in single- or two-layer RC elements. This paper discusses experimental and theoretical results, obtained by the authors in the recent three decades. The authors have payed attention to a structural phenomenon that many design features (parameters, properties, etc. at ultimate limit state (ULS of a structure are twice higher (or lower than at initial loading state. This phenomenon is evident at material properties, structures (or their elements, and static and/or dynamic structural response. The phenomenon is based on two ideas that were developed by first author: quasi-isotropic state of a structure at ULS and minimax principle. This phenomenon is supported by experimental and theoretical results, obtained for various structures, like beams, frames, spatial structures, and structural joints under static or/and dynamic loadings. This study provides valuable indicators for experiments’ planning and estimation of structural state. The phenomenon provides additional equation(s for calculating parameters that are usually obtained experimentally and can lead to developing design concepts and RC theory, in which the number of empirical design coefficients will be minimal.

  7. Thermal performance experiments on ultimate heat sinks, spray ponds, and cooling ponds

    International Nuclear Information System (INIS)

    Hadlock, R.K.


    A program of measurement on a Battelle-Northwest (BNW) spray pond has been completed to prove an integrated instrumentation system for application in future field experiments. The measurement programs in the field will produce data of relevance to the design and understanding of performance for ultimate heat sinks as components of emergency core cooling systems. In the absence of active emergency cooling systems, the data will be obtained on analog systems--prime candidates among these are the naturally-occurring hot ponds at Yellowstone National Park and man-made hot cooling ponds at Savannah River National Laboratory as well as spray ponds at various industrial facilities. The proof experiment has provided data that not only illustrate the effectiveness of the instrumentation system but also display interesting site-specific heat transfer processes. The data to be obtained in the field will also be site specific but must be of generic applicability in modeling for design and performance purposes. The integrated instrumentation system will evolve, through modest modifications and substantial supplementation, to provide the requisite data for the more demanding situation of work in and about hot water

  8. Genotyping by sequencing (GBS, an ultimate marker-assisted selection (MAS tool to accelerate plant breeding

    Directory of Open Access Journals (Sweden)

    Jiangfeng eHe


    Full Text Available Marker-assisted selection (MAS refers to the use of molecular markers to assist phenotypic selections in crop improvement. Several types of molecular markers, such as single nucleotide polymorphism (SNP, have been identified and effectively used in plant breeding. The application of next-generation sequencing (NGS technologies has led to remarkable advances in whole genome sequencing, which provides ultra-throughput sequences to revolutionize plant genotyping and breeding. To further broaden NGS usages to large crop genomes such as maize and wheat, genotyping by sequencing (GBS has been developed and applied in sequencing multiplexed samples that combine molecular marker discovery and genotyping. GBS is a novel application of NGS protocols for discovering and genotyping SNPs in crop genomes and populations. The GBS approach includes the digestion of genomic DNA with restriction enzymes followed by the ligation of barcode adapter, PCR amplification and sequencing of the amplified DNA pool on a single lane of flow cells. Bioinformatic pipelines are needed to analyze and interpret GBS datasets. As an ultimate MAS tool and a cost-effective technique, GBS has been successfully used in implementing genome-wide association study (GWAS, genomic diversity study, genetic linkage analysis, molecular marker discovery and genomic selection (GS under a large scale of plant breeding programs.

  9. Ultimate pressure capacity assessment of R FRC PCCV based on the tension stiffening tests

    Energy Technology Data Exchange (ETDEWEB)

    Hahm, Dae Gi; Choun, Young Sun [KAERI, Daejeon (Korea, Republic of)


    The use of fibers in concrete or cement composites can enhance the performance of structural elements. Fibers have been used for a cement mixture to increase the toughness and tensile strength, and to improve the cracking and deformation characteristics. The addition of fibers into concrete can improve the ductility and increase the tensile resistance of concrete structures. Recently, the application of fibers to prestressed concrete containment vessels (PCCVs) has been a major research topic. However, the tensile stiffening behavior of reinforced - fiber reinforced concrete (RFRC) is not fully developed yet especially for specimens using large diameter re bars. In nuclear power plant (NPP) PCCVs, large diameter re bars are applied. Therefore, the tensile stiffening behavior model should be developed to assess ultimate pressure capacity (UPC) of R FRC PCCVs. In this study, we modeled the tensile stiffening behavior of R FRC PCCVs by using recently developed model, and assessed the UPC of R FRC PCCVs. To do this, we performed tension stiffening test of R FRC with large diameter re bar.

  10. The CRISPR-Cas9 technology: Closer to the ultimate toolkit for targeted genome editing. (United States)

    Quétier, Francis


    The first period of plant genome editing was based on Agrobacterium; chemical mutagenesis by EMS (ethyl methanesulfonate) and ionizing radiations; each of these technologies led to randomly distributed genome modifications. The second period is associated with the discoveries of homing and meganuclease enzymes during the 80s and 90s, which were then engineered to provide efficient tools for targeted editing. From 2006 to 2012, a few crop plants were successfully and precisely modified using zinc-finger nucleases. A third wave of improvement in genome editing, which led to a dramatic decrease in off-target events, was achieved in 2009-2011 with the TALEN technology. The latest revolution surfaced in 2013 with the CRISPR-Cas9 system, whose high efficiency and technical ease of use is really impressive; scientists can use in-house kits or commercially available kits; the only two requirements are to carefully choose the location of the DNA double strand breaks to be induced and then to order an oligonucleotide. While this close-to- ultimate toolkit for targeted editing of genomes represents dramatic scientific progress which allows the development of more complex useful agronomic traits through synthetic biology, the social acceptance of genome editing remains regularly questioned by anti-GMO citizens and organizations. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  11. Design Dependent Cutoff Frequency of Nanotransistors Near the Ultimate Performance Limit (United States)

    Kordrostami, Zoheir; Sheikhi, M. Hossein; Zarifkar, Abbas


    We have studied the effect of different structural designs of double gate MOSFETs (DG-MOSFETs) and carbon nanotube field effect transistors (CNTFETs) on the cutoff frequency (fT). The effects of metallic contacts with Schottky barriers, gate work function, dual material gate (DMG), halo doped channel and lightly doped drain and source (LDDS) architectures on the fT have been investigated for DG-MOSFETs and CNTFETs and the design dependent fT for both types of transistors has been studied for the first time. The simulations are based on the Schrödinger-Poisson solvers developed for each nanotransistor separately. The ballistic limit has been studied as the ultimate performance limit of the DG-MOSFETs and CNTFETs. The results of this paper, for the first time, show how some designations used for modification of short channel effects or current-voltage characteristics affect the fT. The results revealed that the cutoff frequencies of both types of the transistors exhibit the same behavior with changing design parameters. We have shown that the Schottky barriers, parasitic capacitances and halo doping reduce the fT and have proposed the DMG and LDDS artchitectures as ways to increase the fT for DG-MOSFETs and CNTFETs for the first time.

  12. Pareto-Optimal Evaluation of Ultimate Limit States in Offshore Wind Turbine Structural Analysis

    Directory of Open Access Journals (Sweden)

    Michael Muskulus


    Full Text Available The ultimate capacity of support structures is checked with extreme loads. This is straightforward when the limit state equations depend on a single load component, and it has become common to report maxima for each load component. However, if more than one load component is influential, e.g., both axial force and bending moments, it is not straightforward how to define an extreme load. The combination of univariate maxima can be too conservative, and many different combinations of load components can result in the worst value of the limit state equations. The use of contemporaneous load vectors is typically non-conservative. Therefore, in practice, limit state checks are done for each possible load vector, from each time step of a simulation. This is not feasible when performing reliability assessments and structural optimization, where additional, time-consuming computations are involved for each load vector. We therefore propose to use Pareto-optimal loads, which are a small set of loads that together represent all possible worst case scenarios. Simulations with two reference wind turbines show that this approach can be very useful for jacket structures, whereas the design of monopiles is often governed by the bending moment only. Even in this case, the approach might be useful when approaching the structural limits during optimization.

  13. Rethinking Therapeutic Misconception in Biobanking

    DEFF Research Database (Denmark)

    Tupasela, Aaro; Snell, Karoliina; Cañada, Jose


    Some authors have noted that in biobank research participants may be guided by what is called therapeutic misconception, whereby participants attribute therapeutic intent to research procedures.This article argues that the notion of therapeutic misconception is increasingly less justified when...... underpinnings for the need to separate research and treatment, and thus the notion of therapeutic misconception in the fi rst place. We call this tension between research and treatment ambivalent research advancement to highlight the difficulties that various actors have in managing such shifts within...

  14. Therapeutic cloning: The ethical limits

    International Nuclear Information System (INIS)

    Whittaker, Peter A.


    A brief outline of stem cells, stem cell therapy and therapeutic cloning is given. The position of therapeutic cloning with regard to other embryonic manipulations - IVF-based reproduction, embryonic stem formation from IVF embryos and reproductive cloning - is indicated. The main ethically challenging stages in therapeutic cloning are considered to be the nuclear transfer process including the source of eggs for this and the destruction of an embryo to provide stem cells for therapeutic use. The extremely polarised nature of the debate regarding the status of an early human embryo is noted, and some potential alternative strategies for preparing immunocompatible pluripotent stem cells are indicated

  15. Therapeutic cloning in the mouse (United States)

    Mombaerts, Peter


    Nuclear transfer technology can be applied to produce autologous differentiated cells for therapeutic purposes, a concept termed therapeutic cloning. Countless articles have been published on the ethics and politics of human therapeutic cloning, reflecting the high expectations from this new opportunity for rejuvenation of the aging or diseased body. Yet the research literature on therapeutic cloning, strictly speaking, is comprised of only four articles, all in the mouse. The efficiency of derivation of embryonic stem cell lines via nuclear transfer is remarkably consistent among these reports. However, the efficiency is so low that, in its present form, the concept is unlikely to become widespread in clinical practice. PMID:12949262

  16. A Verification Logic for GOAL Agents (United States)

    Hindriks, K. V.

    Although there has been a growing body of literature on verification of agents programs, it has been difficult to design a verification logic for agent programs that fully characterizes such programs and to connect agent programs to agent theory. The challenge is to define an agent programming language that defines a computational framework but also allows for a logical characterization useful for verification. The agent programming language GOAL has been originally designed to connect agent programming to agent theory and we present additional results here that GOAL agents can be fully represented by a logical theory. GOAL agents can thus be said to execute the corresponding logical theory.

  17. Path-Goal Theory of Leadership (United States)


    Leadership and Turnover Among Managers ," Organization Behavior and Human Performance, 10(1973), pp. 184-200; R. J. House, "A Path-Goal Theory of...of Leadership ." 6R. J. House and G. Dessler, "Path-Goal Theory of Leadership " R. M. Stqg- dill. Managers , Employees, Organization (Ohio State...of Control." 23 R. J. House, "Notes on the Path-Goal Theory of Leadership " (University of Toronto, Faculty of Management Studies, May 1974). 24 R

  18. The Use of Personal Projects Analysis to Enhance Occupational Therapy Goal Identification

    Directory of Open Access Journals (Sweden)

    Mary Egan


    Full Text Available Background: Client-centered occupational therapy begins with the identification of personally-relevant patient goals. This study aimed to determine whether the elicitation module of Personal Projects Analysis (PPA could help patients in an acquired brain injury day hospital program identify more meaningful goals than those identified using the Canadian Occupational Performance Measure (COPM alone. Method: Ten patients completed the COPM. They rated the importance of each goal and their confidence that they could attain each goal. During the next session, using the elicitation module of PPA, they identified personal projects just prior to their brain injuries, current personal projects, and future desired personal projects. They were then invited to revise their COPM goals and re-rate them for importance and confidence. Results: Following completion of the elicitation module of PPA, seven participants changed at least one goal. Of the goals that were changed, half were revised to include the mention of another person. There were no significant changes in average goal importance or perceived attainability. Occupational therapists reported that the elicitation module of PPA helped them get to know their patients better and identify potential therapeutic occupations. Discussion: The elicitation module of PPA may help people develop goals that are more embedded in their social contexts.

  19. Development and construct validation of the Client-Centredness of Goal Setting (C-COGS) scale. (United States)

    Doig, Emmah; Prescott, Sarah; Fleming, Jennifer; Cornwell, Petrea; Kuipers, Pim


    Client-centred philosophy is integral to occupational therapy practice and client-centred goal planning is considered fundamental to rehabilitation. Evaluation of whether goal-planning practices are client-centred requires an understanding of the client's perspective about goal-planning processes and practices. The Client-Centredness of Goal Setting (C-COGS) was developed for use by practitioners who seek to be more client-centred and who require a scale to guide and evaluate individually orientated practice, especially with adults with cognitive impairment related to acquired brain injury. To describe development of the C-COGS scale and examine its construct validity. The C-COGS was administered to 42 participants with acquired brain injury after multidisciplinary goal planning. C-COGS scores were correlated with the Canadian Occupational Performance Measure (COPM) importance scores, and measures of therapeutic alliance, motivation, and global functioning to establish construct validity. The C-COGS scale has three subscales evaluating goal alignment, goal planning participation, and client-centredness of goals. The C-COGS subscale items demonstrated moderately significant correlations with scales measuring similar constructs. Findings provide preliminary evidence to support the construct validity of the C-COGS scale, which is intended to be used to evaluate and reflect on client-centred goal planning in clinical practice, and to highlight factors contributing to best practice rehabilitation.

  20. Predicting race performance in triathlon: the role of perfectionism, achievement goals, and personal goal setting. (United States)

    Stoeber, Joachim; Uphill, Mark A; Hotham, Sarah


    The question of how perfectionism affects performance is highly debated. Because empirical studies examining perfectionism and competitive sport performance are missing, the present research investigated how perfectionism affected race performance and what role athletes' goals played in this relationship in two prospective studies with competitive triathletes (Study 1: N = 112; Study 2: N = 321). Regression analyses showed that perfectionistic personal standards, high performance-approach goals, low performance-avoidance goals, and high personal goals predicted race performance beyond athletes' performance level. Moreover, the contrast between performance-avoidance and performance-approach goals mediated the relationship between perfectionistic personal standards and performance, whereas personal goal setting mediated the relationship between performance-approach goals and performance. The findings indicate that perfectionistic personal standards do not undermine competitive performance, but are associated with goals that help athletes achieve their best possible performance.

  1. Shopping the way to my goals: an analysis of purchase impact on perceived goal progress

    Directory of Open Access Journals (Sweden)

    Manuela Albornoz Gonçalves

    Full Text Available Abstract This article examines the impact of goal related purchases on goal progress perception, and whether this perception depends on the strength of association between product and goal. To test how consumers perceive the act of purchasing goal-related products, three experiments were conducted in an online setting. Participants exposed to purchasing situations perceived greater goal progress than participants exposed to usage situation or a control group. In addition, studies show that this effect is a result of strength of association between product and goal, since participants exposed to more instrumental products perceived greater goal progress than participants exposed to less instrumental products. Therefore, these studies demonstrate how consumers interpret goal related purchases, and the mechanism that influences this interpretation.

  2. Voluntary euthanasia, physician-assisted suicide, and the goals of medicine. (United States)

    Varelius, Jukka


    It is plausible that what possible courses of action patients may legitimately expect their physicians to take is ultimately determined by what medicine as a profession is supposed to do and, consequently, that we can determine the moral acceptability of voluntary euthanasia and physician-assisted suicide on the basis of identifying the proper goals of medicine. This article examines the main ways of defining the proper goals of medicine found in the recent bioethics literature and argues that they cannot provide a clear answer to the question of whether or not voluntary euthanasia and physician-assisted suicide are morally acceptable. It is suggested that to find a plausible answer to this question and to complete the task of defining the proper goals of medicine, we must determine what is the best philosophical theory about the nature of prudential value.

  3. Undergraduate students' goals for chemistry laboratory coursework (United States)

    DeKorver, Brittland K.

    Chemistry laboratory coursework has the potential to offer many benefits to students, yet few of these learning goals are realized in practice. Therefore, this study seeks to characterize undergraduate students' learning goals for their chemistry laboratory coursework. Data were collected by recording video of students completing laboratory experiments and conducting interviews with the students about their experiences that were analyzed utilizing the frameworks of Human Constructivism and Self-Regulated Learning. A cross-sectional sampling of students allowed comparisons to be made among students with varying levels of chemistry experience and interest in chemistry. The student goals identified by this study were compared to previously described laboratory learning goals of the faculty who instruct these courses in an effort to identify potential avenues to improve laboratory learning.

  4. Integration of Millennium Development Goals into Physical ...

    African Journals Online (AJOL)

    Integration of Millennium Development Goals into Physical Education programme: ... African Journal for Physical Activity and Health Sciences ... the UN in terms of sustainable human development and how graduates of physical education and ...

  5. Achieving the sustainable development goals: transforming public ...

    African Journals Online (AJOL)

    Achieving the sustainable development goals: transforming public health ... PROMOTING ACCESS TO AFRICAN RESEARCH ... The conference focused on transforming public health education and practice in the context of South Africa.

  6. Purinergic Signalling: Therapeutic Developments

    Directory of Open Access Journals (Sweden)

    Geoffrey Burnstock


    Full Text Available Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and characterised, which includes four subtypes of the P1 (adenosine receptor, seven subtypes of P2X ion channel receptors and 8 subtypes of the P2Y G protein-coupled receptor. Early studies were largely concerned with the physiology, pharmacology and biochemistry of purinergic signalling. More recently, the focus has been on the pathophysiology and therapeutic potential. There was early recognition of the use of P1 receptor agonists for the treatment of supraventricular tachycardia and A2A receptor antagonists are promising for the treatment of Parkinson’s disease. Clopidogrel, a P2Y12 antagonist, is widely used for the treatment of thrombosis and stroke, blocking P2Y12 receptor-mediated platelet aggregation. Diquafosol, a long acting P2Y2 receptor agonist, is being used for the treatment of dry eye. P2X3 receptor antagonists have been developed that are orally bioavailable and stable in vivo and are currently in clinical trials for the treatment of chronic cough, bladder incontinence, visceral pain and hypertension. Antagonists to P2X7 receptors are being investigated for the treatment of inflammatory disorders, including neurodegenerative diseases. Other investigations are in progress for the use of purinergic agents for the treatment of osteoporosis, myocardial infarction, irritable bowel syndrome, epilepsy, atherosclerosis, depression, autism, diabetes, and cancer.

  7. Dental therapeutic systems. (United States)

    Iqbal, Zeenat; Jain, Nilu; Jain, Gaurav K; Talegaonkar, Sushama; Ahuja, Alka; Khar, Roop K; Ahmad, Farhan J


    The recognition of periodontal diseases as amenable to local antibiotherapy has resulted in a paradigmatic shift in treatment modalities of dental afflictions. Moreover the presence of antimicrobial resistance, surfacing of untoward reactions owing to systemic consumption of antibiotics has further advocated the use of local delivery of physiologically active substances into the periodontal pocket. While antimicrobials polymerized into acrylic strips, incorporated into biodegradable collagen and hollow permeable cellulose acetate fibers, multiparticulate systems, bio-absorbable dental materials, biodegradable gels/ointments, injectables, mucoadhesive microcapsules and nanospheres will be more amenable for direct placement into the periodontal pockets the lozenges, buccoadhesive tablets, discs or gels could be effectively used to mitigate the overall gingival inflammation. Whilst effecting controlled local delivery of a few milligram of an antibacterial agent within the gingival crevicular fluid for a longer period of time, maintaining therapeutic concentrations such delivery devices will circumvent all adverse effects to non- oral sites. Since the pioneering efforts of Goodson and Lindhe in 1989, delivery at gingival and subgingival sites has witnessed a considerable progress. The interest in locally active systems is evident from the patents being filed and granted. The present article shall dwell in reviewing the recent approaches being proffered in the field. Patents as by Shefer, et al. US patent, 6589562 dealing with multicomponent biodegradable bioadhesive controlled release system for oral care products, Lee, et al. 2001, US patent 6193994, encompassing a locally administrable, biodegradable and sustained-release pharmaceutical composition for periodontitis and process for preparation thereof and method of treating periodontal disease as suggested by Basara in 2004via US patent 6830757, shall be the types of intellectual property reviewed and presented in

  8. Goal-Directed Visual Attention Drives Health Goal Priming: An Eye-Tracking Experiment

    NARCIS (Netherlands)

    Laan, van der Laura N.; Hooge, I.T.C.; Smeets, P.A.M.


    Objective: Several lab and field experiments have shown that goal priming interventions can be highly effective in promoting healthy food choices. Less is known, however, about the mechanisms by which goal priming affects food choice. This experiment tested the hypothesis that goal priming affects

  9. Curricular Goals and Personal Goals in Master's Thesis Projects: Dutch Student-Supervisor Dyads (United States)

    de Kleijn, Renske A. M.; Meijer, Paulien C.; Brekelmans, Mieke; Pilot, Albert


    To be effective, feedback should be goal-related. In order to better understand goal-related feedback in Master's thesis projects, the present study explores the goals of supervisors and students in supervision dyads and similarities and differences within and between these dyads. Twelve supervisors and students were interviewed, and their goals…

  10. Goal-Directed and Goal-Less Imitation in Autism Spectrum Disorder (United States)

    Wild, Kelly S.; Poliakoff, Ellen; Jerrison, Andrew; Gowen, Emma


    To investigate how people with Autism are affected by the presence of goals during imitation, we conducted a study to measure movement kinematics and eye movements during the imitation of goal-directed and goal-less hand movements. Our results showed that a control group imitated changes in movement kinematics and increased the level that they…

  11. Goal Conflict and Goal Commitment among Campus Parking Administrators in Higher Education (United States)

    McKinney, David R.


    The purpose of this study was to determine the degree to which campus parking administrators in public higher education perceive they are experiencing goal conflict and the degree to which they differ in commitment to goals related to generating revenue and goals related to academics and service. The study also sought to determine the relationship…

  12. Different Goals for Different Folks: A Cross-Cultural Study of Achievement Goals across Nine Cultures (United States)

    King, Ronnel B.; McInerney, Dennis M.; Nasser, Ramzi


    Goals are important predictors of key educational outcomes. However, most of the research on goal theory has been conducted in Western societies. In this study we examine how different types of goals (mastery, performance, social, and extrinsic) derived from personal investment theory are associated with key learning outcomes across nine cultural…

  13. Goal Orientations of General Chemistry Students via the Achievement Goal Framework (United States)

    Lewis, Scott E.


    The Achievement Goal Framework describes students' goal orientations as: task-based, focusing on the successful completion of the task; self-based, evaluating performance relative to one's own past performance; or other-based, evaluating performance relative to the performance of others. Goal orientations have been used to explain student success…

  14. Goal Setting in Principal Evaluation: Goal Quality and Predictors of Achievement (United States)

    Sinnema, Claire E. L.; Robinson, Viviane M. J.


    This article draws on goal-setting theory to investigate the goals set by experienced principals during their performance evaluations. While most goals were about teaching and learning, they tended to be vaguely expressed and only partially achieved. Five predictors (commitment, challenge, learning, effort, and support) explained a significant…

  15. Self-regulation of health behavior: social psychological approaches to goal setting and goal striving. (United States)

    Mann, Traci; de Ridder, Denise; Fujita, Kentaro


    The goal of this article is to review and highlight the relevance of social psychological research on self-regulation for health-related theory and practice. We first review research on goal setting, or determining which goals to pursue and the criteria to determine whether one has succeeded. We discuss when and why people adopt goals, what properties of goals increase the likelihood of their attainment, and why people abandon goals. We then review research on goal striving, which includes the planning and execution of actions that lead to goal attainment, and the processes that people use to shield their goals from being disrupted by other competing goals, temptations, or distractions. We describe four types of strategies that people use when pursuing goals. We find that self-regulation entails the operation of a number of psychological mechanisms, and that there is no single solution that will help all people in all situations. We recommend a number of strategies that can help people to more effectively set and attain health-related goals. We conclude that enhancing health behavior requires a nuanced understanding and sensitivity to the varied, dynamic psychological processes involved in self-regulation, and that health is a prototypical and central domain in which to examine the relevance of these theoretical models for real behavior. We discuss the implications of this research for theory and practice in health-related domains. PsycINFO Database Record (c) 2013 APA, all rights reserved.

  16. Achievement goals, self-handicapping, and performance: a 2 x 2 achievement goal perspective. (United States)

    Ntoumanis, Nikos; Thøgersen-Ntoumani, Cecilie; Smith, Alison L


    Elliot and colleagues (2006) examined the effects of experimentally induced achievement goals, proposed by the trichotomous model, on self-handicapping and performance in physical education. Our study replicated and extended the work of Elliot et al. by experimentally promoting all four goals proposed by the 2 x 2 model (Elliot & McGregor, 2001), measuring the participants' own situational achievement goals, using a relatively novel task, and testing the participants in a group setting. We used a randomized experimental design with four conditions that aimed to induce one of the four goals advanced by the 2 x 2 model. The participants (n = 138) were undergraduates who engaged in a dart-throwing task. The results pertaining to self-handicapping partly replicated Elliot and colleagues' findings by showing that experimentally promoted performance-avoidance goals resulted in less practice. In contrast, the promotion of mastery-avoidance goals did not result in less practice compared with either of the approach goals. Dart-throwing performance did not differ among the four goal conditions. Personal achievement goals did not moderate the effects of experimentally induced goals on self-handicapping and performance. The extent to which mastery-avoidance goals are maladaptive is discussed, as well as the interplay between personal and experimentally induced goals.

  17. Goals, Methods, and Progress in Neuroeconomics


    Colin F. Camerer


    Neuroeconomics shares the main goals of microeconomics: to understand what causes choices, and the welfare properties of choice. The novel goal is linking mathematical constructs and observable behavior to mechanistic details of neural circuitry. Several complementary methods are used. An initial insight from neuroscience is that distinct systems guide choice: Pavlovian and instrumental conditioning (learning) of state-value and response-value associations, overlearned habits, and model- (or ...

  18. Responding to the Millennium Development Goals

    DEFF Research Database (Denmark)

    Enemark, Stig


    , disease, illiteracy, environmental degradation and discrimination of women. These goals are now placed at the heart of the global agenda. The Summit’s Millennium Declaration also outlined a wide range of commitments in human rights, good governance, and democracy. This paper presents the Millennium Goals......-agencies and especially the World Bank to develop a FIG strategy and advise the FIG council on necessary actions....

  19. Driving Danish Defence Towards Political Goals (United States)


    discuss the political agreement.90 The Defence Chief of Staff is interviewed in the same paper along the same lines, where he provides an in- depth ...DRIVING DANISH DEFENCE TOWARDS POLITICAL GOALS A thesis presented to the Faculty of the U.S. Army Command and General Staff...4. TITLE AND SUBTITLE Driving Danish Defence Towards Political Goals 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

  20. Therapeutical aspect of trichomoniasis

    Directory of Open Access Journals (Sweden)

    Vukićević Jelica


    Full Text Available Trichomoniasis is frequent, parasitic and sexually transmitted infection of genitourinary tract. It is treated by metronidazole (5-nitroimidazole according to protocol recommended by Center for Disease Control (CDC formerly called: Communicable Disease Center [19]. The resistance of Trichomonas vaginalis (TV strains to metronidazole (MND was described in USA in 1960, and later on in many European countries [8, 9, 10, 11, 12, 13]. In these cases, due to persistent trichomonas infection, it is necessary to repeat MND treatment with moderate modification of dose and/or length of its application. Nevertheless, oncogenic and toxic effects of MND have to be taken into consideration. OBJECT The aim of this study was to investigate and analyze the incidence of TV in STD and lower susceptibility of certain TV strains to MND were analyzed. MATERIAL AND METHODS In three-year period (1999-2001 612 patients (244 females and 368 males suspected of STD were examined clinically and microbiologically at the Institute of Dermatovenereology in Belgrade. The patients detected for TV were treated according to CDC protocol. The affected were considered cured if there was no manifest clinical infection, and no TV verified by microbiological test. Results TV was isolated in 216 patients (35.29 % of all subjects. Trichomonas infection was found in 90 (36.88 % out of 244 tested females and in 126 (32.34 % of 368 males. Clinically manifested infection, with extensive urethral and vaginal secretion, was recorded in 161 patients, while the asymptomatic form was found in 55 subjects. This result indicates the predominance of manifested trichomonas infections (75.54 % of cases. The difference of distribution of clinical forms of trichomoniasis, in relation to sex, was not statistically significant (c2=0.854; p>0.05. The patients with verified trichomonas infection were treated by metronidazole according to CDC protocol. The recommended therapeutical scheme consisted of three

  1. A preliminary declaration of sustainability ethics: making peace with the ultimate bioexecutioner

    Directory of Open Access Journals (Sweden)

    John Cairns Jr.


    Full Text Available Sustainability is a utopian vision that requires living harmoniously with nature, which will exact harsh penalties on species that exceed Earth's carrying capacity and violate nature's laws. To make this vision a reality, humankind needs a global ethical consensus on sustainable use of the planet - sustainability ethics. Sustainability ethics has the goal of developing a sustainable, mutualistic relationship between humankind and the interdependent web of life that serves as Earth's ecological life support system. The quest for sustainable use of the planet is a value judgment that has more than one component. Arguably, the most important is increased attention to and compassion for posterity's quality of life, in short, leaving a habitable planet for future generations. This requires leaving natural capital and the ecosystem serves it provides undiminished at the least and increased at best. Although material possessions can be left to direct descendants, protecting the planet's ecological life support system must not only be for all of humankind's descendants but those of the 30+ million other species with which we share the planet. This is difficult because the recipients are distance (as individuals both temporally and spatially. Therefore, this quest will not be realised until an agreement emerges on the values and attitudes necessary to make sustainbility a reality. Science can then develop the standards and criteria necessary to reach this goal. In view of present unsustainable practices, a basis ethical consensus is necessary to develop sustainable practices.

  2. Safety goals for nuclear power plant operation

    International Nuclear Information System (INIS)


    This report presents and discusses the Nuclear Regulatory Commission's, Policy Statement on Safety Goals for the Operation of Nuclear Power Plants. The safety goals have been formulated in terms of qualitative goals and quantitative design objectives. The qualitative goals state that the risk to any individual member of the public from nuclear power plant operation should not be a significant contributor to that individual's risk of accidental death or injury and that the societal risks should be comparable to or less than those of viable competing technologies. The quantitative design objectives state that the average risks to individual and the societal risks of nuclear power plant operation should not exceed 0.1% of certain other risks to which members of the US population are exposed. A subsidiary quantitative design objective is established for the frequency of large-scale core melt. The significance of the goals and objectives, their bases and rationale, and the plan to evaluate the goals are provided. In addition, public comments on the 1982 proposed policy statement and responses to a series of questions that accompanied the 1982 statement are summarized

  3. Motivational Function of Plans and Goals

    Directory of Open Access Journals (Sweden)

    Sabina Alispahić


    Full Text Available The academic literature shows that by helping tune out distractions, goals can get individuals' to try harder, work longer, and achieve more. Goals that people set for themselves and that are devoted to attaining mastery are usually healthy. But goals imposed by others—sales targets, quarterly returns, standardized test scores—can sometimes have dangerous side effects (Pink, 2009. Because understanding action demands understanding intention, the idea of motivation is natural and readily expressed in everyday language. Cognitive mental events like goals and expectancies can function as a “spring to action”, a moving force that energizes and directs action in purposive ways (Reeve, 2005. Cognitive studies of motivation are dealing with relationship between cognition and action. Literature is indicating a few cognitive elements that can have motivational significance. The article presents the overview of theory and research about the motivational function of plans and goals, according to Goal setting theory (Locke & Latham, 1990 and Self-determination Theory (Deci & Ryan, 2000. Suggestions for additional research are also indicated.

  4. An integrated framework for sustainable development goals

    Directory of Open Access Journals (Sweden)

    David Griggs


    Full Text Available The United Nations (UN Rio+20 summit committed nations to develop a set of universal sustainable development goals (SDGs to build on the millennium development goals (MDGs set to expire in 2015. Research now indicates that humanity's impact on Earth's life support system is so great that further global environmental change risks undermining long-term prosperity and poverty eradication goals. Socioeconomic development and global sustainability are often posed as being in conflict because of trade-offs between a growing world population, as well as higher standards of living, and managing the effects of production and consumption on the global environment. We have established a framework for an evidence-based architecture for new goals and targets. Building on six SDGs, which integrate development and environmental considerations, we developed a comprehensive framework of goals and associated targets, which demonstrate that it is possible, and necessary, to develop integrated targets relating to food, energy, water, and ecosystem services goals; thus providing a neutral evidence-based approach to support SDG target discussions. Global analyses, using an integrated global target equation, are close to providing indicators for these targets. Alongside development-only targets and environment-only targets, these integrated targets would ensure that synergies are maximized and trade-offs are managed in the implementation of SDGs.

  5. The millennium development goals and tobacco control. (United States)

    Collishaw, Neil E


    The eight Millennium Development Goals were proposed by the UN Secretary-General in 2001. They are goals with measurable targets to be achieved by 2015 or earlier. The Goals were distilled from the 2000 United Nations Millennium Declaration, a sweeping statement of development values, principles, objectives and proposed actions. The Framework Convention on Tobacco Control (FCTC) is a demonstrable translation of some of the ideas in the Millennium Declaration into reality. With 165(i) Parties, the FCTC does more than just improve global tobacco control: * The FCTC contributes to achievement of many of the Millennium Development Goals, and benefits from success in implementation of the Goals in other sectors. * The treaty itself is a demonstration of strengthened international and national rule of law, central tenets of the Millennium Declaration. * The FCTC expands international law into the health sector and provides better balance of international law among economic, environmental, social and health sectors. The Millennium Declaration calls for a more equitable distribution of the benefits of globalization, and the FCTC delivers this result. * The FCTC provides a model for addressing other unsolved global problems through greater use of international law. Alcohol control and dietary improvements including greater control of empty calories in manufactured foods are examples of problems that may benefit from greater governance by international law. Were that to come to pass, those new treaties would also improve implementation of the Millennium Declaration and the Millennium Development Goals.

  6. Probabilistic safety assessment goals in Canada

    International Nuclear Information System (INIS)

    Snell, V.G.


    CANDU safety philosphy, both in design and in licensing, has always had a strong bias towards quantitative probabilistically-based goals derived from comparative safety. Formal probabilistic safety assessment began in Canada as a design tool. The influence of this carried over later on into the definition of the deterministic safety guidelines used in CANDU licensing. Design goals were further developed which extended the consequence/frequency spectrum of 'acceptable' events, from the two points defined by the deterministic single/dual failure analysis, to a line passing through lower and higher frequencies. Since these were design tools, a complete risk summation was not necessary, allowing a cutoff at low event frequencies while preserving the identification of the most significant safety-related events. These goals gave a logical framework for making decisions on implementing design changes proposed as a result of the Probabilistic Safety Analysis. Performing this analysis became a regulatory requirement, and the design goals remained the framework under which this was submitted. Recently, there have been initiatives to incorporate more detailed probabilistic safety goals into the regulatory process in Canada. These range from far-reaching safety optimization across society, to initiatives aimed at the nuclear industry only. The effectiveness of the latter is minor at very low and very high event frequencies; at medium frequencies, a justification against expenditures per life saved in other industries should be part of the goal setting

  7. Flexible goal attribution in early mindreading. (United States)

    Michael, John; Christensen, Wayne


    The 2-systems theory developed by Apperly and Butterfill (2009; Butterfill & Apperly, 2013) is an influential approach to explaining the success of infants and young children on implicit false-belief tasks. There is extensive empirical and theoretical work examining many aspects of this theory, but little attention has been paid to the way in which it characterizes goal attribution. We argue here that this aspect of the theory is inadequate. Butterfill and Apperly's characterization of goal attribution is designed to show how goals could be ascribed by infants without representing them as related to other psychological states, and the minimal mindreading system is supposed to operate without employing flexible semantic-executive cognitive processes. But research on infant goal attribution reveals that infants exhibit a high degree of situational awareness that is strongly suggestive of flexible semantic-executive cognitive processing, and infants appear moreover to be sensitive to interrelations between goals, preferences, and beliefs. Further, close attention to the structure of implicit mindreading tasks--for which the theory was specifically designed--indicates that flexible goal attribution is required to succeed. We conclude by suggesting 2 approaches to resolving these problems. (c) 2016 APA, all rights reserved).

  8. The U.S. Gas Flooding Experience: CO2 Injection Strategies and Impact on Ultimate Recovery

    Energy Technology Data Exchange (ETDEWEB)

    Nunez-Lopez, Vanessa [The University of Texas at Austin; Hosseini, Seyyed; Gil-Egui, Ramon


    The Permian Basin in West Texas and southwestern New Mexico has seen 45 years of oil reserve growth through CO2 enhanced oil recovery (CO2 EOR). More than 60 CO2 EOR projects are currently active in the region’s limestone, sandstone and dolomite reservoirs. Water alternating gas (WAG) has been the development strategy of choice in the Permian for several technical and economic reasons. More recently, the technology started to get implemented in the much more porous and permeable clastic depositional systems of the onshore U.S. Gulf Coast. Continued CO2 injection (CGI), as opposed to WAG, was selected as the injection strategy to develop Gulf Coast oil fields, where CO2 injection volumes are significantly larger (up to 6 times larger) than those of the Permian. We conducted a compositional simulation based study with the objective of comparing the CO2 utilization ratios (volume of CO2 injected to produce a barrel of oil) of 4 conventional and novel CO2 injection strategies: (1) continuous gas injection (CGI), (2) water alternating gas (WAG), (3) water curtain injection (WCI), and (4) WAG and WCI combination. These injection scenarios were simulated using the GEM module from the Computer Modeling Group (CMG). GEM is an advanced general equation-of-state compositional simulator, which includes equation of state, CO2 miscible flood, CO2/brine interactions, and complex phase behavior. The simulator is set up to model three fluid phases including water, oil, and gas. Our study demonstrates how the selected field development strategy has a significant impact on the ultimate recovery of CO2-EOR projects, with GCI injection providing maximum oil recovery in absolute volume terms, but with WAG offering a more balanced technical-economical approach.

  9. Squat Biomechanical Modeling Results from Exercising on the Hybrid Ultimate Lifting Kit (United States)

    Gallo, Christopher A.; Thompson, William K.; Lewandowski, Beth E.; Jagodnik, Kathleen M.


    Long duration space travel will expose astronauts to extended periods of reduced gravity. Since gravity is not present to aid loading, astronauts will use resistive and aerobic exercise regimes for the duration of the space flight to minimize loss of bone density, muscle mass and aerobic capacity that occurs during exposure to a reduced gravity environment. Unlike the International Space Station (ISS), the area available for an exercise device in the next generation of spacecraft is limited and therefore compact resistance exercise device prototypes are being developed. The Advanced Resistive Exercise Device (ARED) currently on the ISS is being used as a benchmark for the functional performance of these new devices. Biomechanical data collection and computational modeling aid the device design process by quantifying the joint torques and the musculoskeletal forces that occur during exercises performed on the prototype devices. The computational models currently under development utilize the OpenSim software, an open source code for musculoskeletal modeling, with biomechanical input data from test subjects for estimation of muscle and joint loads. The subjects are instrumented with reflective markers for motion capture data collection while exercising on the Hybrid Ultimate Lifting Kit (HULK) prototype device. Ground reaction force data is collected with force plates under the feet and device loading is recorded through load cells internal to the HULK. Test variables include applied device load, narrow or wide foot stance, slow or fast cadence and the harness or long bar interface between the test subject and the device. Data is also obtained using free weights for a comparison to the resistively loaded exercise device. This data is input into the OpenSim biomechanical model, which has been scaled to match the anthropometrics of the test subject, to calculate the body loads. The focus of this presentation is to summarize the results from the full squat exercises

  10. The ultimate response guideline simulation and analysis by using (TRACE) for Lungmen ABWR nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Hao-Tzu [Atomic Energy Council, Inst. of Nuclear Energy Research, Taoyuan City, Taiwan (China); Yang, Shu-Ming; Chen, Shao-Wen; Wang, Jong-Rong; Shih, Chunkuan [National Tsing Hua Univ., Inst. of Nuclear Engineering and Science, HsinChu, Taiwan (China)


    In this research, the TRACE/SNAP model of Lungmen ABWR nuclear power plant (NPP) has been established for the simulation and analysis of ultimate response guideline (URG). The main actions of URG are depressurization and low pressure water injection of reactor and containment venting. This research focuses to assess the URG utility of Lungmen NPP under Fukushima-like conditions. This study consists of three steps. The first step is the establishment of Lungmen NPP TRACE/SNAP model. In order to evaluate the system response of TRACE/SNAP model, FSAR data (MSIV closure and loss of feedwater flow transient) were used to compare with the results of TRACE. The second step is the URG simulation and analysis under Fukushima-like conditions by using Lungmen NPP TRACE/SNAP model. In this step, the no URG case was also performed in order to evaluate the URG effectiveness of Lungmen NPP. In order to confirm the mechanical property and integrity of fuel rods, the final step is FRAPTRAN analysis. According to TRACE analysis results, the URG can keep the peak cladding temperature (PCT) below the criteria 1088.7 K under Fukushima-like conditions which indicates that Lungmen NPP can be controlled in a safe situation. Nevertheless, if Lungmen NPP does not perform the URG under Fukushima-like conditions, the water level may drop lower than TAF after 1100 s which means a safety issue about the fuel rods may be generated. The analysis results of FRAPTRAN also indicate the integrity of fuel rods cannot be kept under the above conditions.

  11. The in vitro digestibility of beef varies with its inherent ultimate pH. (United States)

    Farouk, Mustafa M; Wu, Guojie; Frost, Deborah A; Clerens, Stefan; Knowles, Scott O


    Animal carcasses and cuts of meat are usually differentiated and valued according to size and compositional attributes. An underappreciated variable of red meat is its inherent ultimate pH (pHu) value, which affects organoleptic and processing characteristics. This study tests the hypothesis that high pHu aged meat would be more digestible than low pHu unaged (fresh) meat. Longissimus dorsi muscles collected from 59 bull carcasses had pHu values of 5.6-6.9. These were aged for 21 days at -1.5 °C, then raw and cooked (72 °C) samples were enzymatically digested at 37 °C with pepsin (pH 1.9 for 90 min) followed by pancreatin (pH 8.0 for an additional 120 min) to simulate conditions in the stomach and small intestine, respectively. Meat proteins and peptides in the digests were separated by 1D SDS PAGE. Regardless of pHu, ageing or cooking, most sarcoplasmic and myofibrillar proteins were rapidly digested by pepsin, with concomitant release of products identified by LC-MS/MS as mainly myosin-1, -2 and -7, α-actinin-2 or -3 and tropomyosin beta and alpha chains. These products were resistant to further digestion for the entire 210 min duration of the incubation. In terms of rate and extent of digestibility of these resistant products, high pHu > low pHu (P unaged (P meat samples increased with increasing pHu (P meat was highly digestible but could be further differentiated on the basis of its pHu and the ease of digestibility of proteins. Specific carcasses or cuts could be targeted to consumer groups in order to provide benefits and add value.

  12. Long-time safety aspects of ultimate storage of transuranium elements

    International Nuclear Information System (INIS)

    Storck, R.


    Based on the amounts of transuranium elements generated in nuclear reactors, the inventories of these elements in the repository are described for various ultimate disposal strategies. The data are used to give an outline description of accident-induced ingress of brines into the backfilled repository shaft during the post-closure period and the resulting mechanisms of a mobilization of the transuranium elements and their escape from the repository, and to calculate amounts released. The effects of the released transuranium elements on the biosphere and the different contributions of the various isotopes to the calculated radiation exposure are given as an estimate and are described in more detail by means of data determined by parameter variation. The effects of transuranium elements during the entire migration process are restricted to the production of daughter nuclides, especially of the uranium isotopes. They give no particular contribution to environmental radiation exposure because of their low mobility. With the only exception of Np-237 which, due to its long half-time and relatively good migration capacity, can reach the biosphere. The contributions of the transuranium elements to the dose maxima, caused by the daughter products, of the uranium isotopes or the neptunium are calculated to be about 50%. All publications to date presenting a safety analysis of the site of the Gorleben repository assume the dose maxima of all uranium isotopes together to be approx. 10%, and those of the neptunium isotope approx. 20%, referring to the most significant fission products. This indicates that uranium or neptunium are of secondary significance in the process, and the other transuranium elements are only third-rate. (orig./HP) [de


    International Nuclear Information System (INIS)



    The Nuclear Power Engineering Corporation (NUPEC) of Japan has been conducting a multi-year research program to investigate the behavior of nuclear power plant piping systems under large seismic loads. The objectives of the program are: to develop a better understanding of the elasto-plastic response and ultimate strength of nuclear piping; to ascertain the seismic safety margin of current piping design codes; and to assess new piping code allowable stress rules. Under this program, NUPEC has performed a large-scale seismic proving test of a representative nuclear power plant piping system. In support of the proving test, a series of materials tests, static and dynamic piping component tests, and seismic tests of simplified piping systems have also been performed. As part of collaborative efforts between the United States and Japan on seismic issues, the US Nuclear Regulatory Commission (USNRC) and its contractor, the Brookhaven National Laboratory (BNL), are participating in this research program by performing pre-test and post-test analyses, and by evaluating the significance of the program results with regard to safety margins. This paper describes BNL's pre-test analysis to predict the elasto-plastic response for one of NUPEC's simplified piping system seismic tests. The capability to simulate the anticipated ratcheting response of the system was of particular interest. Analyses were performed using classical bilinear and multilinear kinematic hardening models as well as a nonlinear kinematic hardening model. Comparisons of analysis results for each plasticity model against test results for a static cycling elbow component test and for a simplified piping system seismic test are presented in the paper

  14. The Ultimate Pile Bearing Capacity from Conventional and Spectral Analysis of Surface Wave (SASW) Measurements (United States)

    Faizah Bawadi, Nor; Anuar, Shamilah; Rahim, Mustaqqim A.; Mansor, A. Faizal


    A conventional and seismic method for determining the ultimate pile bearing capacity was proposed and compared. The Spectral Analysis of Surface Wave (SASW) method is one of the non-destructive seismic techniques that do not require drilling and sampling of soils, was used in the determination of shear wave velocity (Vs) and damping (D) profile of soil. The soil strength was found to be directly proportional to the Vs and its value has been successfully applied to obtain shallow bearing capacity empirically. A method is proposed in this study to determine the pile bearing capacity using Vs and D measurements for the design of pile and also as an alternative method to verify the bearing capacity from the other conventional methods of evaluation. The objectives of this study are to determine Vs and D profile through frequency response data from SASW measurements and to compare pile bearing capacities obtained from the method carried out and conventional methods. All SASW test arrays were conducted near the borehole and location of conventional pile load tests. In obtaining skin and end bearing pile resistance, the Hardin and Drnevich equation has been used with reference strains obtained from the method proposed by Abbiss. Back analysis results of pile bearing capacities from SASW were found to be 18981 kN and 4947 kN compared to 18014 kN and 4633 kN of IPLT with differences of 5% and 6% for Damansara and Kuala Lumpur test sites, respectively. The results of this study indicate that the seismic method proposed in this study has the potential to be used in estimating the pile bearing capacity.

  15. Effect of Incorporation of Antifungal Agents on the Ultimate Tensile Strength of Temporary Soft Denture Liners. (United States)

    Neppelenbroek, Karin Hermana; Lima, Jozely Francisca Mello; Hotta, Juliana; Galitesi, Lucas Lulo; Almeida, Ana Lucia Pompéia Fraga; Urban, Vanessa Migliorini


    To investigate the ultimate tensile strength of temporary soft denture liners modified by minimum inhibitory concentrations (MICs) of antifungal agents for Candida albicans biofilm (SC5314) determined in previous microbiological research. Dumbbell-shaped specimens (n = 7) with a central cross-sectional area of 6 × 3 × 33 mm were produced by Softone and Trusoft, without (control) or with incorporation of drugs in powder form at MICs for C. albicans biofilm (per g of material powder): nystatin (0.032 g), chlorhexidine diacetate (0.064 g), ketoconazole (0.128 g), miconazole (0.256 g), and itraconazole (0.256 g). After plasticization, specimens were immersed in distilled water at 37°C for 24 hours, 7 or 14 days, and then tested in tension in a universal testing machine at 40 mm/min. Data of tensile strength (MPa) and elongation percentage (%) were submitted to 3-way ANOVA and Tukey's test (α = 0.05). At the end of 14 days, the tensile strength for both materials was significantly lower in the groups modified by miconazole and itraconazole compared to the other groups (p 0.05). After 7 and 14 days in water, miconazole and itraconazole added into both materials resulted in significantly lower elongation percentages compared to the other antifungal agents and control (p 0.05). The addition of the nystatin, chlorhexidine, and ketoconazole at MICs for C. albicans biofilm resulted in no harmful effects on the tensile strength and elongation percentage of the temporary soft denture liner materials up to 14 days. © 2017 by the American College of Prosthodontists.

  16. Different Ultimate Factors Define Timing of Breeding in Two Related Species.

    Directory of Open Access Journals (Sweden)

    Veli-Matti Pakanen

    Full Text Available Correct reproductive timing is crucial for fitness. Breeding phenology even in similar species can differ due to different selective pressures on the timing of reproduction. These selection pressures define species' responses to warming springs. The temporal match-mismatch hypothesis suggests that timing of breeding in animals is selected to match with food availability (synchrony. Alternatively, time-dependent breeding success (the date hypothesis can result from other seasonally deteriorating ecological conditions such as intra- or interspecific competition or predation. We studied the effects of two ultimate factors on the timing of breeding, synchrony and other time-dependent factors (time-dependence, in sympatric populations of two related forest-dwelling passerine species, the great tit (Parus major and the willow tit (Poecile montanus by modelling recruitment with long-term capture-recapture data. We hypothesized that these two factors have different relevance for fitness in these species. We found that local recruitment in both species showed quadratic relationships with both time-dependence and synchrony. However, the importance of these factors was markedly different between the studied species. Caterpillar food played a predominant role in predicting the timing of breeding of the great tit. In contrast, for the willow tit time-dependence modelled as timing in relation to conspecifics was more important for local recruitment than synchrony. High caterpillar biomass experienced during the pre- and post-fledging periods increased local recruitment of both species. These contrasting results confirm that these species experience different selective pressures upon the timing of breeding, and hence responses to climate change may differ. Detailed information about life-history strategies is required to understand the effects of climate change, even in closely related taxa. The temporal match-mismatch hypothesis should be extended to consider

  17. Assessment of cooling tower (ultimate heat sink) performance in the Byron individual plant examination

    International Nuclear Information System (INIS)

    Campbell, H.D.; Hawley, J.T.; Klopp, G.T.; Thelen, W.A.


    A time-dependent model of the Byron Nuclear Generation Station safety-related cooling towers has been developed for use with the Byron PRA (IPE). The model can either be run in a stand-alone program with externally supplied heat loads, or can be directly coupled into MAAP (Modular Accident Analysis Program). The primary feature of the model is a careful tracking of the basin temperature through the progression of different severe accidents. Heat removal rates from containment, both from containment fan-coolers and the residual heat removal system, are determined by the feed-back of this time-varying return temperature. Also, the inventory of the basin is tracked in time, and this is controlled by make-up, evaporative losses due to the heat load supplied to the towers, and the possibility of unsecured blowdown. The model has been used to determine the overall capabilities and vulnerabilities of the Byron Ultimate Heat Sink (UHS). It was determined that the UHS is very reliable with respect to maintaining acceptably low basin temperatures, requiring only at most two of eight operating cooling tower fans. Further, when the two units have their Essential Service Water (ESW) systems cross-tied, one of four ESW operating pumps is sufficient to handle the loads from the accident unit with the other unit proceeding to an orderly shutdown. The major vulnerability of the Byron UHS is shown to be the ability to maintain inventory, although the time-scales for basin dry-out are relatively long, being eight to twenty-one hours, depending upon when blowdown is secured. (author)

  18. Human performance evaluation: The procedures of ultimate response guideline for nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Kang-Hung, E-mail: [Institute of Nuclear Energy Research, Atomic Engery Council, No. 1000, Whenhua Road, Jiaan Village, Longtan Township, Taoyuan County, Taiwan (China); Hwang, Sheue-Ling, E-mail: [Department of Industrial Engineering and Engineering Management, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu, Taiwan 30013, Taiwan (China)


    Highlights: • This study adopts SPAR-H to evaluate HEPs in the URG procedures. • The involvement of URG procedures could reduce CDF significantly. • Upgrading the training level of staff will enhance the reliability effectively. • Aiding the plant manager in making URG decision will enhance the reliability. - Abstract: In the nuclear accident which occurred in Japan on March 11, 2011, several units of Fukushima conventional BWR experienced a total loss of power and water supply triggered by a heavy earthquake and subsequent Tsunami which were outside design models. In the past, when an accident occurred, operators in nuclear power plants (NPP) followed emergency operating procedures (EOPs) or severe accident management guidance (SAMG). However, EOP and SAMG are symptom-based procedures to cope with severe transients and accidents, depending on real-time operational parameters. Ultimate response guidelines (URG), a plant specific interim remedy action plan, was developed to manage accidents caused by compound disasters which exceed design models. The URG guides the plant operators’ conduct of reactor depressurization, core cooling water injection, and containment venting. This study adopts NUREG/CR-6883 (Standardized Plant Analysis Risk Human Reliability Analysis, SPAR-H) to evaluate human error probabilities (HEPs) of action and diagnosis in the current URG procedures. We found the human reliability of URG procedures analyzed by SPAR-H is about 85% (depending on different decision makers). Upgrading the training level of staff or enhancing plant managers ability to decide whether to execute URG will enhance the human reliability of URG procedures.

  19. Exubera. Inhale therapeutic systems. (United States)

    Bindra, Sanjit; Cefalu, William T


    Inhale, in colaboration with Pfizer and Aventis Pharma (formerly Hoechst Marion Roussel; HMR), is developing an insulin formulation utilizing its pulmonary delivery technology for macromolecules for the potential treatment of type I and II diabetes. By July 2001, the phase III program had been completed and the companies had begun to assemble data for MAA and NDA filings; however, it was already clear at this time that additional data might be required for filing. By December 2001, it had been decided that the NDA should include an increased level of controlled, long-term pulmonary safety data in diabetic patients and a major study was planned to be completed in 2002, with the NDA filed thereafter (during 2002). US-05997848 was issued to Inhale Therapeutic Systems in December 1999, and corresponds to WO-09524183, filed in February 1995. Equivalent applications have appeared to date in Australia, Brazil, Canada, China, Czech Republic, Europe, Finland, Hungary, Japan, Norway, New Zealand, Poland and South Africa. This family of applications is specific to pulmonary delivery of insulin. In February 1999, Lehman Brothers gave this inhaled insulin a 60% probability of reaching market, with a possible launch date of 2001. The analysts estimated peak sales at $3 billion in 2011. In May 2000, Aventis predicted that estimated peak sales would be in excess of $1 billion. In February 2000, Merrill Lynch expected product launch in 2002 and predicted that it would be a multibillion-dollar product. Analysts Merril Lynch predicted, in September and November 2000, that the product would be launched by 2002, with sales in that year of e75 million, rising to euro 500 million in 2004. In April 2001, Merrill Lynch predicted that filing for this drug would occur in 2001. Following the report of the potential delay in regulatory filing, issued in July 2001, Deutsche Banc Alex Brown predicted a filing would take place in the fourth quarter of 2002 and launch would take place in the first

  20. Goal conflict and goal facilitation as predictors of daily accelerometer-assessed physical activity. (United States)

    Presseau, Justin; Tait, Richard I; Johnston, Derek W; Francis, Jill J; Sniehotta, Falko F


    To test whether perceptions of conflicting and facilitating personal goals, and actual daily time spent in their pursuit, predict accelerometer-assessed physical activity (PA). A prospective multilevel design with a daily accelerometer-based assessment of PA over 1 week was used (N = 106). Participants' personal goals were elicited using personal projects analysis. Participants then rated their personal goals in terms of how they were perceived to facilitate and conflict with their regular PA. Items assessing PA-specific intention and perceived behavioral control (PBC) were also embedded within the baseline measures. For the subsequent 7 consecutive days, participants completed a daily diary based on the day reconstruction method, indicating the time spent in daily episodes involving each of their personal goals, and wore an RT3 tri-axial accelerometer. The main outcome was accelerometer-assessed daily time spent in moderate to vigorous physical activity (MVPA). Random intercept multilevel models indicated that perceived goal facilitation, but not perceived goal conflict, predicted MVPA over and above intention and PBC. Daily time pursuing conflicting goals negatively predicted MVPA when subsequently added to the model and in so doing, attenuated the association between perceived goal facilitation and MVPA. Perceived goal facilitation predicts objectively measured PA over and above intention and PBC, but daily time spent in pursuit of conflicting personal goals provides a better account of how alternative goals relate to engaging in regular PA.

  1. Does monitoring goal progress promote goal attainment? A meta-analysis of the experimental evidence. (United States)

    Harkin, Benjamin; Webb, Thomas L; Chang, Betty P I; Prestwich, Andrew; Conner, Mark; Kellar, Ian; Benn, Yael; Sheeran, Paschal


    Control theory and other frameworks for understanding self-regulation suggest that monitoring goal progress is a crucial process that intervenes between setting and attaining a goal, and helps to ensure that goals are translated into action. However, the impact of progress monitoring interventions on rates of behavioral performance and goal attainment has yet to be quantified. A systematic literature search identified 138 studies (N = 19,951) that randomly allocated participants to an intervention designed to promote monitoring of goal progress versus a control condition. All studies reported the effects of the treatment on (a) the frequency of progress monitoring and (b) subsequent goal attainment. A random effects model revealed that, on average, interventions were successful at increasing the frequency of monitoring goal progress (d+ = 1.98, 95% CI [1.71, 2.24]) and promoted goal attainment (d+ = 0.40, 95% CI [0.32, 0.48]). Furthermore, changes in the frequency of progress monitoring mediated the effect of the interventions on goal attainment. Moderation tests revealed that progress monitoring had larger effects on goal attainment when the outcomes were reported or made public, and when the information was physically recorded. Taken together, the findings suggest that monitoring goal progress is an effective self-regulation strategy, and that interventions that increase the frequency of progress monitoring are likely to promote behavior change. (c) 2016 APA, all rights reserved).

  2. Goal setting in psychotherapy: the relevance of approach and avoidance goals for treatment outcome. (United States)

    Wollburg, Eileen; Braukhaus, Christoph


    The present study is the first aimed at investigating the influence of goal definition on treatment outcome in a sample of depressed patients. Data from 657 inpatients admitted to a psychosomatic clinic in Germany being treated in a cognitive-behavioral therapy program were analyzed. Treatment goals were identified as either approach or avoidance, and the sample was classified accordingly. Patients who identified approach goals only were placed in the approach group, and those who identified at least one avoidance goal were placed in the avoidance group. Results showed that framing goals using avoidance terms was associated with less symptomatic improvement but did not affect goal attainment. Findings from this research should be utilized in practice not only for process management such as individual treatment planning but also to control outcome quality. Furthermore, goal definition should be considered as a control variable in research on depression.

  3. Teaching practical wisdom in medicine through clinical judgement, goals of care, and ethical reasoning. (United States)

    Kaldjian, Lauris Christopher


    Clinical decision making is a challenging task that requires practical wisdom-the practised ability to help patients choose wisely among available diagnostic and treatment options. But practical wisdom is not a concept one typically hears mentioned in medical training and practice. Instead, emphasis is placed on clinical judgement. The author draws from Aristotle and Aquinas to describe the virtue of practical wisdom and compare it with clinical judgement. From this comparison, the author suggests that a more complete understanding of clinical judgement requires its explicit integration with goals of care and ethical values. Although clinicians may be justified in assuming that goals of care and ethical values are implicit in routine decision making, it remains important for training purposes to encourage habits of clinical judgement that are consciously goal-directed and ethically informed. By connecting clinical judgement to patients' goals and values, clinical decisions are more likely to stay focused on the particular interests of individual patients. To cultivate wise clinical judgement among trainees, educational efforts should aim at the integration of clinical judgement, communication with patients about goals of care, and ethical reasoning. But ultimately, training in wise clinical judgement will take years of practice in the company of experienced clinicians who are able to demonstrate practical wisdom by example. By helping trainees develop clinical judgement that incorporates patients' goals of care and ethical reasoning, we may help lessen the risk that 'clinical judgement' will merely express 'the clinician's judgement.'

  4. Achieving Sustainable Development Goals from a Water Perspective

    Directory of Open Access Journals (Sweden)

    Anik Bhaduri


    Full Text Available Efforts to meet human water needs only at local scales may cause negative environmental externality and stress on the water system at regional and global scales. Hence, assessing SDG targets requires a broad and in-depth knowledge of the global to local dynamics of water availability and use. Further, Interconnection and trade-offs between different SDG targets may lead to sub-optimal or even adverse outcome if the set of actions are not properly pre-designed considering such interlinkages. Thus scientific research and evidence have a role to play in facilitating the implementation of SDGs through assessments and policy engagement from global to local scales. The paper addresses some of these challenges related to implementation and monitoring the targets of the Sustainable Development Goals from a water perspective, based on the key findings of a conference organised in 2015 with the focus on three essential aspects of SDGs- indicators, interlinkages and implementation. The paper discusses that indicators should not be too simple but ultimately deliver sustainability measures. The paper finds that remote sensing and earth observation technologies can play a key role in supporting the monitoring of water targets. It also recognises that implementing SDGs is a societal process of development, and there is need to link how SDGs relate to public benefits and communicate this to the broader public.

  5. Concept for an ultimate storage facility for heat-generating radioactive waste in clay stone in Germany

    International Nuclear Information System (INIS)

    Bollingerfehr, Wilhelm; Poehler, Matthias


    According to the German reference ultimate storage concept heat-generating radioactive waste from the operation of nuclear power stations should be stored permanently maintenance-free and in a non-recoverable manner in a salt formation. Within the framework of investigations into the utilisation of alternative host rocks a concept for an ultimate storage facility in clay stone was developed in an R and D project. For this purpose all important aspects of the design, development, operation and shutdown were taken into account for a model region in northern Germany. It was established that storage in 50 m deep vertical boreholes in a mine at a depth of about 350 m appears to be the most practical solution for an ultimate storage facility in clay stone. Compared to the reference concept in salt an ultimate storage facility in clay stone requires solid support of all mine openings with steel arches or shotcrete. Because of the lower maximum permissible temperature in the backfilling material (bentonite) the area required for the ultimate storage facility is about five times larger. A period of more than 100 years is estimated from survey to shutdown. (orig.)

  6. Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges (United States)

    Vugmeyster, Yulia; Xu, Xin; Theil, Frank-Peter; Khawli, Leslie A; Leach, Michael W


    Significant progress has been made in understanding pharmacokinetics (PK), pharmacodynamics (PD), as well as toxicity profiles of therapeutic proteins in animals and humans, which have been in commercial development for more than three decades. However, in the PK arena, many fundamental questions remain to be resolved. Investigative and bioanalytical tools need to be established to improve the translation of PK data from animals to humans, and from in vitro assays to in vivo readouts, which would ultimately lead to a higher success rate in drug development. In toxicology, it is known, in general, what studies are needed to safely develop therapeutic proteins, and what studies do not provide relevant information. One of the major complicating factors in nonclinical and clinical programs for therapeutic proteins is the impact of immunogenicity. In this review, we will highlight the emerging science and technology, as well as the challenges around the pharmacokinetic- and safety-related issues in drug development of mAbs and other therapeutic proteins. PMID:22558487

  7. Health, vital goals, and central human capabilities. (United States)

    Venkatapuram, Sridhar


    I argue for a conception of health as a person's ability to achieve or exercise a cluster of basic human activities. These basic activities are in turn specified through free-standing ethical reasoning about what constitutes a minimal conception of a human life with equal human dignity in the modern world. I arrive at this conception of health by closely following and modifying Lennart Nordenfelt's theory of health which presents health as the ability to achieve vital goals. Despite its strengths I transform Nordenfelt's argument in order to overcome three significant drawbacks. Nordenfelt makes vital goals relative to each community or context and significantly reflective of personal preferences. By doing so, Nordenfelt's conception of health faces problems with both socially relative concepts of health and subjectively defined wellbeing. Moreover, Nordenfelt does not ever explicitly specify a set of vital goals. The theory of health advanced here replaces Nordenfelt's (seemingly) empty set of preferences and society-relative vital goals with a human species-wide conception of basic vital goals, or 'central human capabilities and functionings'. These central human capabilities come out of the capabilities approach (CA) now familiar in political philosophy and economics, and particularly reflect the work of Martha Nussbaum. As a result, the health of an individual should be understood as the ability to achieve a basic cluster of beings and doings-or having the overarching capability, a meta-capability, to achieve a set of central or vital inter-related capabilities and functionings. © 2012 John Wiley & Sons Ltd.

  8. Rational quantitative safety goals: a summary

    International Nuclear Information System (INIS)

    Unwin, S.D.; Hayns, M.R.


    We introduce the notion of a Rational Quantitative Safety Goal. Such a goal reflects the imprecision and vagueness inherent in any reasonable notion of adequate safety and permits such vagueness to be incorporated into the formal regulatory decision-making process. A quantitative goal of the form, the parameter x, characterizing the safety level of the nuclear plant, shall not exceed the value x 0 , for example, is of a non-rational nature in that it invokes a strict binary logic in which the parameter space underlying x is cut sharply into two portions: that containing those values of x that comply with the goal and that containing those that do not. Here, we utilize an alternative form of logic which, in accordance with any intuitively reasonable notion of safety, permits a smooth transition of a safety determining parameter between the adequately safe and inadequately safe domains. Fuzzy set theory provides a suitable mathematical basis for the formulation of rational quantitative safety goals. The decision-making process proposed here is compatible with current risk assessment techniques and produces results in a transparent and useful format. Our methodology is illustrated with reference to the NUS Corporation risk assessment of the Limerick Generating Station

  9. Proposed goals for radioactive waste management

    International Nuclear Information System (INIS)

    Bishop, W.P.; Hoos, I.R.; McGrath, P.E.; Metlay, D.S.; Stoneman, W.C.


    A special, seven member, interdisciplinary task group of consultants was established in January 1976 to propose goals for the national waste management program. This is the report of that group. The proposed goals are intended as a basis for the NRC to establish a policy by which to guide and coordinate the activities of government, business, and academic organizations whose responsibility it will be to manage radioactive wastes. The report is based on findings, interpretations and analysis by the authors who examined selected primary literature and interviewed many individuals concerned with waste management. The authors extended the scope of their inquiry and proposed goals to cover 'all technical and societal aspects necessary to an operating waste management system, rather than dealing with the regulatory process alone.' The waste management goals as developed are simple statements of principles which appear to the authors to be important conditions to insure the proper establishment and operation of a system to manage radioactive wastes.' In brief, the goals are designed to protect people and things of value in an equitable manner

  10. Goal Setting to Promote a Health Lifestyle. (United States)

    Paxton, Raheem J; Taylor, Wendell C; Hudnall, Gina Evans; Christie, Juliette


    The purpose of this parallel-group study was to determine whether a feasibility study based on newsletters and telephone counseling would improve goal- setting constructs; physical activity (PA); and fruit and vegetable (F & V) intake in a sample of older adults. Forty-three older adults ( M age = 70 years, >70% Asian, 54% female) living in Honolulu, Hawaii were recruited and randomly assigned to either a PA or F & V intake condition. All participants completed measures of PA, F & V intake, and goal setting mechanisms (i.e., specificity, difficulty, effort, commitment, and persistence) at baseline and 8-weeks. Paired t -tests were used to evaluate changes across time. We found that F & V participants significantly increased F & V intake and mean scores of goal specificity, effort, commitment, and persistence (all p goal setting mechanisms were observed for participants in the PA condition. Overall, our results show that a short-term intervention using newsletters and motivational calls based on goal- setting theory was effective in improving F & V intake; however, more research is needed to determine whether these strategies are effective for improving PA among a multiethnic sample of older adults.

  11. Criteria for achieving actinide reduction goals

    International Nuclear Information System (INIS)

    Liljenzin, J.O.


    In order to discuss various criteria for achieving actinide reduction goals, the goals for actinide reduction must be defined themselves. In this context the term actinides is interpreted to mean plutonium and the so called ''minor actinides'' neptunium, americium and curium, but also protactinium. Some possible goals and the reasons behind these will be presented. On the basis of the suggested goals it is possible to analyze various types of devices for production of nuclear energy from uranium or thorium, such as thermal or fast reactors and accelerator driven system, with their associated fuel cycles with regard to their ability to reach the actinide reduction goals. The relation between necessary single cycle burn-up values, fuel cycle processing losses and losses to waste will be defined and discussed. Finally, an attempt is made to arrange the possible systems on order of performance with regard to their potential to reduce the actinide inventory and the actinide losses to wastes. (author). 3 refs, 3 figs, 2 tabs

  12. Predictors of binge drinking in adolescents: ultimate and distal factors - a representative study

    Directory of Open Access Journals (Sweden)

    Donath Carolin


    Full Text Available Abstract Background As epidemiological surveys have shown, binge drinking is a constant and wide-spread problem behavior in adolescents. It is not rare to find that more than half of all adolescents engage in this behavior when assessing only the last 4 weeks of time independent of the urbanity of the region they live in. There have been several reviews on predictors of substance consumption in adolescents in general, but there has been less high quality research on predictors of binge drinking, and most studies have not been theoretically based. The current study aimed to analyze the ultimate and distal factors predicting substance consumption according to Petraitis' theory of triadic influence. We assessed the predictive value of these factors with respect to binge drinking in German adolescents, including the identification of influence direction. Methods In the years 2007/2008, a representative written survey of N = 44,610 students in the 9th grade of different school types in Germany was carried out (net sample. The return rate of questionnaires was 88% regarding all students whose teachers or school directors had agreed to participate in the study. In this survey, prevalence of binge drinking was investigated as well as potential predictors from the social/interpersonal, the attitudinal/environmental, and the intrapersonal fields (3 factors of Petraitis. In a multivariate logistic regression analysis, these variables were included after testing for multicollinearity in order to assess their ability to predict binge drinking. Results Prevalence of binge drinking in the last 30 days was 52.3% for the surveyed adolescents with a higher prevalence for boys (56.9% than for girls (47.5%. The two most influential factors found to protect against binge drinking with p p Conclusions Whereas some of the risk and protective factors for binge drinking are not surprising since they are known for substance abuse in general, there are two points that

  13. Proximate and Ultimate Compositional Changes in Corn Stover during Torrefaction using Thermogravimetric Analyzer and Microwaves

    Energy Technology Data Exchange (ETDEWEB)

    Jaya Shankar Tumuluru


    regular and microwaves and their effect on proximate and ultimate composition. Studies indicated that microwave torrefaction is a good way to torrefy the biomass in short periods of time. A maximum calorific value of 21 MJ/kg is achievable at 6 min residence time compared to 15 min using the dry torrefaction technique. Increasing the residence time increased the carbon content where a maximum carbon content of 52.20 % was achievable at lower residence time. The loss of volatiles is comparatively lower compared to dry torrefaction technique. Moisture content of microwave torrefied samples was in between 2-2.5 % (w.b).

  14. Therapeutic Songwriting in Music Therapy Part I

    DEFF Research Database (Denmark)

    Baker, Felicity; Wigram, Tony; Stott, Dave


    Songwriting as therapeutic intervention has received increasing attention in the field of music therapy over the past decade however much of the publications focus on clinical outcomes rather than methods of practice. This paper, part of a two-part research report into trends in the clinical...... practice of songwriting, aims to describe the most frequently employed goal areas across a range of clinical populations and compare these findings with the published literature. Responses to a 21-question on-line survey were obtained from 477 professional music therapists practicing in 29 countries which...... of songwriting clinical practice and the frequency with which songwriting is employed in practice. The data highlights that songwriting is frequently employed in developmental disability and ASD practice, with reports on songwriting with these diagnostic groups being underrepresented in the music therapy...

  15. Human Factor in Therapeutic Relationship

    Directory of Open Access Journals (Sweden)

    Ramazan Akdogan


    Full Text Available herapeutic relationship is a professional relationship that has been structured based on theoretical props. This relationship is a complicated, wide and unique relationship which develops between two people, where both sides' personality and attitudes inevitably interfere. Therapist-client relationship experienced through transference and counter transference, especially in psychodynamic approaches, is accepted as the main aspect of therapeutic process. However, the approaches without dynamic/deterministic tendency also take therapist-client relationship into account seriously and stress uniqueness of interaction between two people. Being a person and a human naturally sometimes may negatively influence the relationship between the therapist and client and result in a relationship going out of the theoretical frame at times. As effective components of a therapeutic process, the factors that stem from being human include the unique personalities of the therapist and the client, their values and their attitude either made consciously or subconsciously. Literature has shown that the human-related factors are too effective to be denied in therapeutic relationship process. Ethical and theoretical knowledge can be inefficient to prevent the negative effects of these factors in therapeutic process at which point a deep insight and supervision would have a critical role in continuing an acceptable therapeutic relationship. This review is focused on the reflection of some therapeutic factors resulting from being human and development of counter transference onto the therapeutic process.

  16. Goal-oriëntation, goal-setting and goal-driven behavior in (minimalist) user instructions

    NARCIS (Netherlands)

    van der Meij, Hans


    This paper opens with a summary of minimalist design strategies that aim to optimize user instructions. Next, it discusses three recent research efforts to further improve these strategies. The common focus in these efforts is the attention to people’s goal-related management and control of

  17. Ultimate Tensile Strength as a Function of Test Rate for Various Ceramic Matrix Composites at Elevated Temperatures (United States)

    Choi, Sung R.; Bansal, Narottam P.; Gyekenyesi, John P.


    Ultimate tensile strength of five different continuous fiber-reinforced ceramic composites, including SiC/BSAS (2D 2 types), SiC/MAS-5 (2D), SiC/SiC (2D enhanced), and C/SiC(2D) was determined as a function of test rate at I 100 to 1200 'C in air. All five composite materials exhibited a significant dependency of ultimate strength on test rate such that the ultimate strength decreased with decreasing test rate, similar to the behavior observed in many advanced monolithic ceramics at elevated temperatures. The application of the preloading technique as well as the prediction of life from one loading configuration (constant stress rate) to another (constant stress loading) for SiC/BSAS suggested that the overall macroscopic failure mechanism of the composites would be the one governed by a power-law type of damage evolution/accumulation, analogous to slow crack growth commonly observed in advanced monolithic ceramics.

  18. Duties of the Physikalisch-Technische Bundesanstalt (PTB) in connection with radioactive waste safeguarding and ultimate storage

    International Nuclear Information System (INIS)

    Roethemeyer, H.


    An outline of the history and duties of the Physikalisch-Technische Bundesanstalt (PTB) is to illustrate that the new duties of the PTB in connection with radioactive substance safeguarding and ultimate storage fit in very well with the range of duties of the PTB. The organisatory and technical accomplishment of these duties in cooperation with a building and operating company and with industry is explained. The department of the PTB for the 'safeguarding and ultimate storage of radioactive wastes' has an examining, appraising and licensing function in connection with construction, operation and shutdown of safety facilities. Methods for the safeguarding and ultimate storage of all the radioactive wastes in the Federal Republic of Germany are described. (HS) [de

  19. Goals and plans in decision making

    Directory of Open Access Journals (Sweden)

    David H. Krantz


    Full Text Available We propose a constructed-choice model for general decision making. The model departs from utility theory and prospect theory in its treatment of multiple goals and it suggests several different ways in which context can affect choice. It is particularly instructive to apply this model to protective decisions, which are often puzzling. Among other anomalies, people insure against non-catastrophic events, underinsure against catastrophic risks, and allow extraneous factors to influence insurance purchases and other protective decisions. Neither expected-utility theory nor prospect theory can explain these anomalies satisfactorily. To apply this model to the above anomalies, we consider many different insurance-related goals, organized in a taxonomy, and we consider the effects of context on goals, resources, plans and decision rules. The paper concludes by suggesting some prescriptions for improving individual decision making with respect to protective measures.

  20. How the Organizational Goals Affect Knowledge Management

    Directory of Open Access Journals (Sweden)

    Wei-Shong Lin


    Full Text Available How to enhance customer satisfaction and technology innovation have been topics of discussion for some time; however, few studies have explored the two issues by applying the knowledge creation theory, and analyzed their differences in knowledge creation activities. The present study aims to explore how the firm’s organizational goal affects its knowledge creation process. Based on Nonaka’s knowledge creation theory, questionnaires were developed and sent to Taiwanese firms in various industries, including the manufacturing and service industries. These questionnaires were collected either by mail or interview. Our findings suggest that externalization and combination activities should be emphasized when the organizational goal is innovation, whereas internalization activity should be emphasized when the organizational goal is customer satisfaction.