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Sample records for ucu ccc uuc

  1. Hot pressing of U-UC cermets and stoichiometric uranium monocarbide; Preparation par frittage sous charge de cermets U-UC et de monocarbure stoechiometrique

    Energy Technology Data Exchange (ETDEWEB)

    Dubuisson, J; Houyvet, A; Le Boulbin, E; Lucas, R; Moranville, C [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    High density fuels, either in uranium monocarbide or in U-UC cermets have been prepared on laboratory-scale, by hot pressing of mixtures of uranium powder and graphite in suitable proportions. Uranium powder is prepared by calcium reduction of UO{sub 2} followed by an acetic leaching at low temperature. An adequate protection-treatment permits the manipulation of the powder in the open air. Uranium and Graphite powders are intimately mixed and then hot pressed in a double effect graphite die at a temperature of 900-1000 deg. C under a charge of 200 kg/cm{sup 2} during 3 hours. A special design of the die avoids the breaking of the graphite during the sintering. In this way, samples are prepared, the characteristics of which are: 1) {+-} 5 pour cent of homogeneity for a ratio height/diameter = 2. 2) almost theoretical density (98 pour cent) 3) low concentration of unreacted carbon (heat treatment of stoichiometric monocarbide can be useful for completion of reaction) 4) the micrographic examination shows: - a network of monocarbide surrounding uranium in the case of low concentration cermets (<2,5 per cent C) - two networks intimately mixed for high concentration cermets (<2,5 per cent C) - a fine grain structure for the monocarbide (10 u). 5) In every case, the X rays examinations show a fine grain structure without any orientation, and no UC{sub 2}. Some indications are given on the physical (thermal cycling, conductibility) and chemical properties (corrosion, reaction with cladding materials). (author)Fren. [French] Une methode de preparation de combustibles de haute densite, soit en monocarbure d'uranium, soit en cermets U-UC, a ete mise au point au laboratoire. Il s'agit du frittage sous charge de melanges de poudres d'uranium et de graphite en proportion convenable. La poudre d'uranium est elaboree par calciothermie de l'oxyde UO{sub 2} suivie d'un lavage acetique a basse temperature. Un traitement de protection adequat pe sa manipulation a l'air. Les poudres

  2. High-field magnetization of UCuGe single crystal

    Czech Academy of Sciences Publication Activity Database

    Andreev, Alexander V.; Mushnikov, N. V.; Gozo, T.; Honda, F.; Sechovský, V.; Prokeš, K.

    346-347, - (2004), s. 132-136 ISSN 0921-4526 R&D Projects: GA ČR GA202/02/0739 Institutional research plan: CEZ:AV0Z1010914 Keywords : uranium intermetallics * UCuGe * high fields * magnetic anisotropy * field-induced phase transition Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.679, year: 2004

  3. Numerical model CCC

    International Nuclear Information System (INIS)

    Bodvarsson, G.S.; Lippmann, M.J.

    1980-01-01

    The computer program CCC (conduction-convection-consolidation), developed at Lawrence Berkeley Laboratory, solves numerically the heat and mass flow equations for a fully saturated medium, and computes one-dimensional consolidation of the simulated systems. The model employs the Integrated Finite Difference Method (IFDM) in discretizing the saturated medium and formulating the governing equations. The sets of equations are solved either by an iterative solution technique (old version) or an efficient sparse solver (new version). The deformation of the medium is calculated using the one-dimensional consolidation theory of Terzaghi. In this paper, the numerical code is described, validation examples given and areas of application discussed. Several example problems involving flow through fractured media are also presented

  4. Crystallographic and magnetic properties of Ba/sub 2/(UCu)O/sub 6/

    Energy Technology Data Exchange (ETDEWEB)

    Padel, L; Poix, P [Paris-11 Univ., 91 - Orsay (France)

    1975-07-07

    Ba/sub 2/(UCu)O/sub 6/ structure can be described by a tetragonal unit cell whose parameters are a=5.777A and c=8.838A. Tetragonal distorsion is attributed to the Jahn-Teller effect of Cu/sup 2 +/; Copper octahedral sites are irregular. The compound presents antiferromagnetic properties with a Neel's temperature of 13K.

  5. XPS study of U, UNi5, UCu5 and UNisub(0.5)Cusub(4.5)

    International Nuclear Information System (INIS)

    Grohs, H.; Hoechst, H.; Steiner, P.; Huefner, S.; Buschow, K.H.J.

    1980-01-01

    Core and valence band spectra of U metal and the intermetallic compounds UNi 5 , UCu 5 and UNisub(0.5)Cusub(4.5) have been measured by X-ray excited photoelectron spectroscopy (XPS). The data indicate that in UNi 5 the configuration is 5f 3 , and in UCu 5 and UNisub(0.5)Cusub(4.5) a mixed valence configuration with fewer 5f electrons than in UNi 5 is present. (author)

  6. Fresh Water Cyanobacteria Geitlerinema sp. CCC728 and Arthrospira sp. CCC729 as an Anticancer Drug Resource

    OpenAIRE

    Srivastava, Akanksha; Tiwari, Ratnakar; Srivastava, Vikas; Singh, Tej Bali; Asthana, Ravi Kumar

    2015-01-01

    An increasing number of cancer patients worldwide, especially in third world countries, have raised concern to explore natural drug resources, such as the less explored fresh water filamentous cyanobacteria. Six strains of cyanobacteria (Phormidium sp. CCC727, Geitlerinema sp. CCC728, Arthrospira sp. CCC729, Phormidium sp. CCC731, Phormidium sp. CCC730, and Leptolyngbya sp. CCC732) were isolated (paddy fields and ponds in the Banaras Hindu University, campus) and five strains screened for ant...

  7. 7 CFR 1494.601 - Acceptance of offers by CCC.

    Science.gov (United States)

    2010-01-01

    ... exporting countries; and the cost effectiveness of the payment of a CCC bonus amount in view of CCC's... exporter's offer by CCC but not later than 10 a.m. of the next business day after the date the offer was... accepted by CCC by 10 a.m. of the next business day after the date for which the offer was submitted for...

  8. Regulation Mechanism of HBV cccDNA

    Directory of Open Access Journals (Sweden)

    Cheng Jun

    2012-06-01

    Full Text Available Covalently closed circular (ccc DNA of hepatitis B virus (HBV existed in the nuclei of HBV infected hepatocytes with a half-life time of 14.3 years in a mathematic model. Viral protein feedback regulation in HBV life cycle to maintain vital viral replication is an important mechanism. Interleukin-6, epithelial growth factor, heme oxygenase-1, histones, and hepatocyte nuclear factors are demonstrated as the key regulators for HBV life cycle. CpG island structure and methylation status are involved in the regulation of HBV DNA replication. Nucleos(tide analogues are widely used in the clinical practice for the treatment of chronic hepatitis B patients, although no evidence indicating a direct inhibiton of HBV cccDNA. In the future, along with the study of HBV life cycle, new drugs including RNA interference technique, will pave the way to eliminate the HBV cccDNA from infected hepatocytes resulting final cure of chronic hepatitis B.

  9. Optimal Kinematic Design of a 6-UCU Kind Gough-Stewart Platform with a Guaranteed Given Accuracy

    Directory of Open Access Journals (Sweden)

    Guojun Liu

    2018-06-01

    Full Text Available The 6-UCU (U-universal joint; C-cylinder joint kind Gough-Stewart platform is extensively employed in motion simulators due to its high accuracy, large payload, and high-speed capability. However, because of the manufacturing and assembling errors, the real geometry may be different from the nominal one. In the design process of the high-accuracy Gough-Stewart platform, one needs to consider these errors. The purpose of this paper is to propose an optimal design method for the 6-UCU kind Gough-Stewart platform with a guaranteed given accuracy. Accuracy analysis of the 6-UCU kind Gough-Stewart platform is presented by considering the limb length errors and joint position errors. An optimal design method is proposed by using a multi-objective evolutionary algorithm, the non-dominated sorting genetic algorithm II (NSGA-II. A set of Pareto-optimal parameters was found by applying the proposed optimal design method. An engineering design case was studied to verify the effectiveness of the proposed method.

  10. Natürel Zeytinyağındaki Uçucu Aroma Bileşenleri ve Duyusal Kalite Üzerine Etkileri

    Directory of Open Access Journals (Sweden)

    Dilşat Bozdoğan Konuşkan

    2015-02-01

    Full Text Available Natürel zeytinyağında bulunan uçucu aroma bileşenlerinin, zeytinyağının lezzet ve aroması üzerine etkisi oldukça önemlidir. Zeytinyağında 280’e yakın uçucu bileşen tespit edilmiş olup, bunlardan 70 kadarının aromaya direkt etkisi olduğu belirlenmiş ve zeytinyağında lezzetten sorumlu grup olarak tanımlanmıştır. Zeytinyağındaki uçucu aroma bileşenlerinin kompozisyonu, başta enzimatik reaksiyonlar olmak üzere, çevresel ve teknolojik faktörlere bağlı olarak değişmektedir. Yüksek kalitedeki zeytinyağlarında bulunan 5 ve 6 karbonlu bileşenler ile özellikle 6 karbonlu uçucu bileşenler, toplam uçucu bileşenlerin % 60-80’ini oluşturmaktadır. Natürel zeytinyağında algılanan meyvemsi, acı-yakıcı (bitter ve keskin-buruk tatlar, duyusal kaliteyi olumlu yönde etkileyerek, tüketici beğenisini sağlamaktadır. Bu çalışmada, natürel zeytinyağında bulunan uçucu aroma bileşenleri ve oluşumları üzerinde etkili olan faktörler ile bunların yağın duyusal kalitesi üzerine olan etkileri üzerinde durulmuştur.

  11. 7 CFR 1401.3 - Payments to persons with outstanding CCC loans.

    Science.gov (United States)

    2010-01-01

    ... sell to CCC a quantity of the commodity pledged as collateral for a CCC loan, as determined by CCC, in... loan collateral the person shall be required to redeem in order to receive payment. The purchase price... the subsequent sale to CCC of the commodity pledged as collateral for such CCC loan, CCC shall make...

  12. The Kondo contribution to the electrical resistivity in UCu sub 5 sub - sub x Ni sub x and the non-Fermi liquid behaviour of UCu sub 4 Ni

    CERN Document Server

    Torre, L D L; Ellerby, M; McEwen, K A

    2003-01-01

    We report on electrical resistivity measurements performed on polycrystalline samples of UCu sub 5 sub - sub x Ni sub x (x = 0.25, 1). In order to extract the Kondo contribution to the resistivity, the experiments were carried out over a wide temperature range (0.4-800 K). From the analysis of our results, we conclude that the Kondo temperature takes values of T sub K approx 240 K for x = 1 and T sub K approx 245 K for x = 0.25, and that for both Ni concentrations the dominant part of the remarkably high residual resistivity (rho(0) approx 400 mu OMEGA cm) corresponds to the Kondo contribution. These results are discussed in comparison with previous analysis of specific heat and magnetic susceptibility data that produced similar values of T sub K. We interpret our results in terms of disorder-driven non-Fermi liquid behaviour for UCu sub 4 Ni, as indicated by the anomalous temperature dependences of the electrical, thermal and magnetic properties previously observed in this compound.

  13. Fresh Water Cyanobacteria Geitlerinema sp. CCC728 and Arthrospira sp. CCC729 as an Anticancer Drug Resource.

    Directory of Open Access Journals (Sweden)

    Akanksha Srivastava

    Full Text Available An increasing number of cancer patients worldwide, especially in third world countries, have raised concern to explore natural drug resources, such as the less explored fresh water filamentous cyanobacteria. Six strains of cyanobacteria (Phormidium sp. CCC727, Geitlerinema sp. CCC728, Arthrospira sp. CCC729, Phormidium sp. CCC731, Phormidium sp. CCC730, and Leptolyngbya sp. CCC732 were isolated (paddy fields and ponds in the Banaras Hindu University, campus and five strains screened for anticancer potential using human colon adenocarcinoma (HT29 and human kidney adenocarcinoma (A498 cancer cell lines. Geitlerinema sp. CCC728 and Arthrospira sp. CCC729 were the most potent as determined by examination of morphological features and by inhibition of growth by graded concentrations of crude extracts and thin-layer chromatography (TLC eluates. Cell cycle analysis and multiplex assays using cancer biomarkers also confirmed Geitlerinema sp. CCC728 and Arthrospira sp. CCC729 as cancer drug resources. Apoptotic studies in the cells of A498 (cancer and MCF-10A (normal human epithelial exposed to crude extracts and TLC fractions revealed no significant impact on MCF-10A cells emphasizing its importance in the development of anticancer drug. Identification of biomolecules from these extracts are in progress.

  14. Fresh Water Cyanobacteria Geitlerinema sp. CCC728 and Arthrospira sp. CCC729 as an Anticancer Drug Resource.

    Science.gov (United States)

    Srivastava, Akanksha; Tiwari, Ratnakar; Srivastava, Vikas; Singh, Tej Bali; Asthana, Ravi Kumar

    2015-01-01

    An increasing number of cancer patients worldwide, especially in third world countries, have raised concern to explore natural drug resources, such as the less explored fresh water filamentous cyanobacteria. Six strains of cyanobacteria (Phormidium sp. CCC727, Geitlerinema sp. CCC728, Arthrospira sp. CCC729, Phormidium sp. CCC731, Phormidium sp. CCC730, and Leptolyngbya sp. CCC732) were isolated (paddy fields and ponds in the Banaras Hindu University, campus) and five strains screened for anticancer potential using human colon adenocarcinoma (HT29) and human kidney adenocarcinoma (A498) cancer cell lines. Geitlerinema sp. CCC728 and Arthrospira sp. CCC729 were the most potent as determined by examination of morphological features and by inhibition of growth by graded concentrations of crude extracts and thin-layer chromatography (TLC) eluates. Cell cycle analysis and multiplex assays using cancer biomarkers also confirmed Geitlerinema sp. CCC728 and Arthrospira sp. CCC729 as cancer drug resources. Apoptotic studies in the cells of A498 (cancer) and MCF-10A (normal human epithelial) exposed to crude extracts and TLC fractions revealed no significant impact on MCF-10A cells emphasizing its importance in the development of anticancer drug. Identification of biomolecules from these extracts are in progress.

  15. 76 FR 44836 - CCC Export Credit Guarantee (GSM-102) Program

    Science.gov (United States)

    2011-07-27

    ... with all regulatory requirements and U.S. anti-money laundering and terrorist financing statutes. The... this timeframe CCC hopes to mitigate the impact of any defaults, as the primary purpose of the NOD is... proposed rule, CCC would add new section 1493.160(c), ``Impact of a default on other existing payment...

  16. A computer simulation of the new Control Centre (CCC)

    CERN Multimedia

    2004-01-01

    In a development crucial for the success of the LHC, CERN will build a Control Centre (CCC) for the operation of all its beams and accelerators. The CCC will be an extension of the existing PCR building at Prévessin and is due to be operational by 1 February 2006.

  17. Kekik Uçucu Yağının Ruminant Beslemede Kullanımı

    OpenAIRE

    ÜNAL, Aylin; KOCABAĞLI, Neşe

    2014-01-01

    ÖZETGeçmiş yıllarda yem katkı maddesi olarak kullanılan antibiyotikler, ruminant beslenmesinde rumen fermantasyonunu geliştirmek, performansı ve yemden yararlanmayı artırmak amacıyla yaygın bir biçimde kullanılmaktaydı. Bu kimyasal yem katkı maddelerinin insan ve hayvan sağlığını olumsuz etkilemesinden dolayı, yeni bir alternatif olan bitkisel kaynaklı yem katkı maddelerine ilgi artmıştır. Bu derlemede, kekik uçucu yağının özellikleri ile ruminant beslemede kullanımları konusunda yurt dışında...

  18. Phenomenological crystal-field model of the magnetic and thermal properties of the Kondo-like system UCu2Si2

    Science.gov (United States)

    Troć, R.; Gajek, Z.; Pikul, A.; Misiorek, H.; Colineau, E.; Wastin, F.

    2013-07-01

    The transport properties described previously [Troć , Phys. Rev. BPRBMDO1098-012110.1103/PhysRevB.85.224434 85, 224434 (2012)] as well as the magnetic and thermal properties presented in this paper, observed for single-crystalline UCu2Si2, are discussed by assuming a dual (localized-itinerant) scenario. The electronic states of the localized 5f electrons in UCu2Si2 are constructed using the effective Hamiltonian known for ionic systems, allowing us to treat the Coulomb, spin-orbital, and crystal-field interactions on equal footing. The space of parameters has been restricted in the initial steps with the aid of the angular overlap model approximation. The final crystal-field parameters, obtained from the refined steps of calculations, are relatively large (in absolute values), which we attribute to the hybridization characteristic of the metallic systems on the verge of localization. The proposed crystal-field model reproduces correctly with satisfactory accuracy the magnetic and thermal properties of UCu2Si2 in agreement also with the transport properties reported previously. Considerable crystal-field splitting of the ground multiplet of 2760 K is responsible for a large anisotropy in the magnetic behavior, observed in the whole temperature range explored.

  19. 7 CFR 1962.19 - Claims against Commodity Credit Corporation (CCC).

    Science.gov (United States)

    2010-01-01

    ... sell or pledge to CCC as loan collateral under the Price Support Program, commodities on which FmHA or... County Supervisor will make immediate demand on the borrower for the amount of the CCC loan or the... CCC. (2) On receiving information from the State Director that CCC has called the borrower's loan, the...

  20. Continuing pollution from the Rum Jungle U-Cu project: A critical evaluation of environmental monitoring and rehabilitation

    Energy Technology Data Exchange (ETDEWEB)

    Mudd, Gavin M., E-mail: Gavin.Mudd@eng.monash.edu.a [Environmental Engineering, Dept of Civil Engineering, Monash University, Clayton, VIC 3800 (Australia); Patterson, James [Environmental Engineering Consultant, Sydney, NSW (Australia)

    2010-05-15

    The former Rum Jungle uranium-copper project, Australia, is an internationally important case study on environmental pollution from and rehabilitation of mining. The Rum Jungle mining project is briefly reviewed, followed by a critical evaluation of monitoring data and pollution loads prior to and after rehabilitation - leading to the conclusion that rehabilitation has clearly failed the test of time after just two decades. The most critical findings are the need to understand pollution cycles holistically, and designing monitoring regimes to match, explicit inclusion of radiological criteria (lacking in original planning), and finally the need to set targets based on environmental criteria. Two examples include polluted groundwater which was excluded from rehabilitation and the poor design, construction and/or performance of engineered soil covers - both leading to increasing acid drainage impacts on the Finniss River. The critical review therefore presents a valuable case study of the environmental performance of uranium mine site rehabilitation. - The Rum Jungle U-Cu project underwent extensive rehabilitation in the 1980's, however, it remains a major cause of pollution to the Finniss River.

  1. Fragmentation production of Ωccc baryons at LHC energies

    International Nuclear Information System (INIS)

    Saleev, V.A.

    2000-01-01

    Within the nonrelativistic quark-diquark model for heavy baryons, the fragmentation functions for the transitions of a c-quark and a doubly charmed vector diquark into an Ω ccc baryon are calculated in the leading order of perturbative QCD. The cross section for Ω ccc production in high-energy hadron interactions is estimated. It is assumed that Ω ccc baryons are formed via the fragmentation of a c quark or a vector (cc) diquark produced in the partonic subprocesses gg → cc-bar, qq-bar → cc-bar, gg → (cc) + c-bar + c-bar, and qq-bar → (cc) + c-bar + c-bar

  2. 76 FR 57940 - CCC Export Credit Guarantee (GSM-102) Program

    Science.gov (United States)

    2011-09-19

    ...: Federal eRulemaking Portal: Go to http://www.regulations.gov . Follow the online instructions to submit....usda.gov . SUPPLEMENTARY INFORMATION: Background On July 27, 2011, CCC published a proposed rule titled... revised program controls to improve program quality, reduce costs, and protect against waste and fraud...

  3. 7 CFR 1494.501 - Submission of offers to CCC.

    Science.gov (United States)

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS EXPORT BONUS PROGRAMS Export Enhancement... contract unit price, delivery terms (e.g., FOB, C&F, etc.); the nature of any arrangements or... CCC bonus; (B) The intention to submit an offer; or (C) The methods or factors used to calculate the...

  4. The cluster burn up programme CCC and a comparison of its results with NPD experiments

    International Nuclear Information System (INIS)

    Hoejerup, C.F.

    1976-10-01

    A brief description is given of the computer programme CCC, which can be used for rod/rod cluster burn up calculations. A comparison of CCC results with some Canadian measurements on NPD fuel is also included. (author)

  5. El Centro de Cardioestimuladores del Uruguay. CCC Medical Devices

    Directory of Open Access Journals (Sweden)

    Pablo Darscht

    2011-05-01

    Full Text Available Estudio de caso del Centro de Cardioestimuladores del Uruguay - CCC Medical Devices preparado a solicitud de Ingenio en el marco del proyecto financiado por la Iniciativa para Incubadoras de InfoDev - Grupo Banco Mundial. Este estudio detalla los pasos seguidos por una empresa nacional con un fuerte factor de innovación y los cambios producidos en el entorno de los negocios de la empresa. El comienzo de una pequeña empresa de marcapasos que tras pasar por diferentes etapas hoy gana mercados en el área de ingeniería para dispositivos médicos para diferentes empresas de investigación biomédica a nivel internacional.AbstractCase study of the Centro de Cardioestimuladores del Uruguay - CCC Medical Devices prepared on behalf of Ingenio within the project financed by de Incubator Initiative of InfoDev-World Bank Group. This study refers to the steps followed by a highly innovative local company and to the changes in its business environment. The start up of a small pacemakers company that after going through different stages is presently increasing its market share in the area of engineering of medical devices for biomedic research companies worldwide.

  6. Passive AC network supplying the integration of CCC-HVDC and VSC-HVDC systems

    OpenAIRE

    BIDADFAR, Ali; ABEDI, Mehrdad; KARRARI, Mehdi

    2014-01-01

    The integration of a capacitor-commutated converter (CCC) high-voltage direct current (HVDC) (CCC-HVDC) and voltage source converter (VSC) HVDC (VSC-HVDC) is proposed in this paper to supply entirely passive AC networks. The key point of this integration is the flat characteristic of the DC voltage of the CCC-HVDC, which provides the condition for the VSC to connect to the CCC DC link via a current regulator. The advantages of the proposed combined infeeding system are the requirement o...

  7. STACHYS RUPESTRIS (LAMIACEAE’İN UÇUCU YAĞ BİLEŞİMİ VE ANTİMİKROBİYAL ETKİLERİ

    Directory of Open Access Journals (Sweden)

    GÖKALP İŞCAN

    2015-12-01

    Full Text Available Stachys cinsi (Lamiaceae dünya üzerinde tanımlanmış yaklaşık 300 türle geniş bir yayılış gösterirken, bu cins ülkemizde %48 endemizm oranıyla 91 tür ve 116 taksa ile temsil edilmektedir. Anadolu’da “Deli adaçayı” veya “Dağ çayı” isimleriyle bilinen Stachys türleri sahip olduğu antibakteriyel, antienflamatuvar, antipiretik, antioksidan ve sitotoksik etkilerinden dolayı, halk arasında cilt hastalıkları, ülser, kanser, solunum rahatsızlıkları ve böbrek hastalıklarında kullanılmaktadır. Yapılan çalışmalarda sekonder metabolitlerinin genellikle iridoit ve flavon glikozitleri ile diterpenler ve uçucu yağlar olduğu ortaya konmuştur.Çalışmamızda Mersin ve civarı için endemik olan Stachys rupestris Montbret et Aucher ex Benth.’in çiçekli toprak üstü kısımlarından hidrodistilasyon ile elde edilen uçucu yağın kompozisyonu gaz kromatografisi/alev iyonlaşma dedektörü ve gaz kromatografisi/kütle spektrometresi ile ortaya konmuştur,  Ana bileşenler a-pinen (%14.4, tetradekanoik asit (%10.3 ve β-karyofillen (%5.3 olarak saptanmıştır.Uçucu yağın patojen bakteri ve maya türlerine karşı antimikrobiyal özellikleri “Klinik ve Laboratuvar Standartları Enstitüsü”nün yayımladığı CLSI M27-A2 ve M7-A7 protokolleri uyarınca mikrodilüsyon duyarlılık testleri ile ortaya konmuştur. Yağın bakterilere kıyasla test edilen Candida türlerine karşı daha etkili olduğu görülmüş, Candida parapsilosis, C. zeylanoides ve C. krusei’yi 31,25 µg/mL, C. zeylanoides’i ise 15,0 µg/mL konsantrasyonda (MİK inhibe ettiği belirlenmiştir.

  8. 7 CFR 1435.504 - Timing of distribution of CCC-owned sugar.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Timing of distribution of CCC-owned sugar. 1435.504... CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS SUGAR PROGRAM Processor Sugar Payment-In-Kind (PIK) Program § 1435.504 Timing of distribution of CCC-owned sugar. Distribution of sugar...

  9. 7 CFR 1486.406 - Will CCC make advance payments to Recipients?

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Will CCC make advance payments to Recipients? 1486... PROGRAM Contributions and Reimbursements § 1486.406 Will CCC make advance payments to Recipients? (a... may make advance payments to a Recipient against an approved project budget. Up to 40 percent of the...

  10. Farklı Tip Türk Rakılarında Temel Uçucu Bileşiklerin Gaz Kromatografisinde Doğrudan Enjeksiyonla Belirlenmesi

    Directory of Open Access Journals (Sweden)

    Seda Özkandan

    2015-02-01

    Full Text Available Bu çalışmada, tek üzüm çeşidinden (Misket, yaş üzümden ve kuru üzüm suması melas alkolü karışımından üretilen farklı tipteki rakıların bileşimleri ve temel uçucu bileşikleri araştırılmıştır. Metanol ve temel uçucu bileşikler (asetaldehit, asetal, metil asetat, etil asetat, 2-bütanol, n-propanol, izobütanol, n-bütanol, aktif amil alkol, izoamil alkol, trans anetol ve estragol AB referans yöntemine göre GC- FID ile belirlenmiştir. Rakıların temel uçucu bileşiklerini, sırasıyla, anason kaynaklı trans anetol ve suma kaynaklı yüksek alkoller, esterler, aldehitler ve uçucu asitler oluşturmuştur. Rakılarda, toplam uçucu madde miktarları uçar asit dahil, 124.99-163.40 g/hL mA arasında, trans anetol miktarları 1038-1380 mg/L arasında, metanol miktarları 43.96-56.91 g/hL mA arasında değişmiştir. En yüksek toplam uçucu madde miktarı Misket üzümünden elde edilen rakıda bulunmuştur. Tek çeşitten ve yaş üzümden üretilen rakıların, karışımdan üretilen rakılara göre daha yüksek miktarlarda toplam uçucu madde ve özellikle yüksek alkoller içerdikleri belirlenmiştir. Yüksek alkol miktarları bakımından tipler arasındaki fark önemli bulunmuştur (P<0.05. Trans anetol miktarı en yüksek yaş üzüm rakısında, en düşük misket rakısında belirlenmiştir. Öte yandan, genel olarak rakıların bileşimlerinin TGK Distile Alkollü İçkiler Tebliği’ne uygun oldukları saptanmıştır.

  11. Establishment of Cre-mediated HBV recombinant cccDNA (rcccDNA) cell line for cccDNA biology and antiviral screening assays.

    Science.gov (United States)

    Wu, Min; Li, Jin; Yue, Lei; Bai, Lu; Li, Yaming; Chen, Jieliang; Zhang, Xiaonan; Yuan, Zhenghong

    2018-04-01

    Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), existing in hepatocyte nuclei as a stable minichromosome, plays a central role in the life cycle of the virus and permits the persistence of infection. Despite being essential for HBV infection, little is known about the molecular mechanisms of cccDNA formation, regulation and degradation, and there is no therapeutic agents directly targeting cccDNA, fore mostly due to the lack of robust, reliable and quantifiable HBV cccDNA models. In this study, combined the Cre/loxP and sleeping beauty transposons system, we established HepG2-derived cell lines integrated with 2-60 copies of monomeric HBV genome flanked by loxP sites (HepG2-HBV/loxP). After Cre expression via adenoviral transduction, 3.3-kb recombinant cccDNA (rcccDNA) bearing a chimeric intron can be produced in the nuclei of these HepG2-HBV/loxP cells. The rcccDNA could be accurately quantified by quantitative PCR using specific primers and cccDNA pool generated in this model could be easily detected by Southern blotting using the digoxigenin probe system. We demonstrated that the rcccDNA was epigenetically organized as the natural minichromosome and served as the template supporting pgRNA transcription and viral replication. As the expression of HBV S antigen (HBsAg) is dependent on the newly generated cccDNA, HBsAg is the surrogate marker of cccDNA. Additionally, the efficacies of 3 classes of anti-HBV agents were evaluated in HepG2-HBV/loxP cells and antiviral activities with different mechanisms were confirmed. These data collectively suggested that HepG2-HBV/loxP cell system will be powerful platform for studying cccDNA related biological mechanisms and developing novel cccDNA targeting drugs. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

  12. Antiviral strategies to eliminate hepatitis B virus covalently closed circular DNA (cccDNA).

    Science.gov (United States)

    Revill, Peter; Locarnini, Stephen

    2016-10-01

    It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are effective at reducing viral replication, they have no impact on the existing cccDNA reservoir. Identifying mechanisms to either eliminate (complete cure) or inactivate (functional cure) HBV cccDNA are a major focus of HBV research worldwide. This review discusses recent advances in efforts to eliminate and/or regulate cccDNA, as well as future directions that may be considered in efforts to cure chronic HBV. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

  13. Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation.

    Science.gov (United States)

    Wei, Zhi-Qiang; Zhang, Yong-Hong; Ke, Chang-Zheng; Chen, Hong-Xia; Ren, Pan; He, Yu-Lin; Hu, Pei; Ma, De-Qiang; Luo, Jie; Meng, Zhong-Ji

    2017-09-14

    To investigate the potential effect of curcumin on hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and the underlying mechanism. A HepG2.2.15 cell line stably transfected with HBV was treated with curcumin, and HBV surface antigen (HBsAg) and e antigen (HBeAg) expression levels were assessed by ELISA. Intracellular HBV DNA replication intermediates and cccDNA were detected by Southern blot and real-time PCR, respectively. The acetylation levels of histones H3 and H4 were measured by Western blot. H3/H4-bound cccDNA was detected by chromatin immunoprecipitation (ChIP) assays. The deacetylase inhibitors trichostatin A and sodium butyrate were used to study the mechanism of action for curcumin. Additionally, short interfering RNAs (siRNAs) targeting HBV were tested along with curcumin. Curcumin treatment led to time- and dose-dependent reductions in HBsAg and HBeAg expression and significant reductions in intracellular HBV DNA replication intermediates and HBV cccDNA. After treatment with 20 μmol/L curcumin for 2 d, HBsAg and cccDNA levels in HepG2.2.15 cells were reduced by up to 57.7% ( P curcumin, accompanied by reductions in H3- and H4-bound cccDNA. Furthermore, the deacetylase inhibitors trichostatin A and sodium butyrate could block the effects of curcumin. Additionally, transfection of siRNAs targeting HBV enhanced the inhibitory effects of curcumin. Curcumin inhibits HBV gene replication via down-regulation of cccDNA-bound histone acetylation and has the potential to be developed as a cccDNA-targeting antiviral agent for hepatitis B.

  14. Pragmatics fragmented: the factor structure of the Dutch children's communication checklist (CCC).

    Science.gov (United States)

    Geurts, Hilde M; Hartman, Catharina; Verté, Sylvie; Oosterlaan, Jaap; Roeyers, Herbert; Sergeant, Joseph A

    2009-01-01

    A number of disorders are associated with pragmatic difficulties. Instruments that can make subdivisions within the larger construct of pragmatics could be important tools for disentangling profiles of pragmatic difficulty in different disorders. The deficits underlying the observed pragmatic difficulties may be different for different disorders. To study the construct validity of a pragmatic language questionnaire. The construct of pragmatics is studied by applying exploratory factor analysis (EFA) and confirmatory factor analysis to the parent version of the Dutch Children's Communication Checklist (CCC; Bishop 1998 ). Parent ratings of 1589 typically developing children and 481 children with a clinical diagnosis were collected. Four different factor models derived from the original CCC scales and five different factor models based on EFA were compared with each other. The models were cross-validated. The EFA-derived models were substantively different from the originally proposed CCC factor structure. EFA models gave a slightly better fit than the models based on the original CCC scales, though neither provided a good fit to the parent data. Coherence seemed to be part of language form and not of pragmatics, which is in line with the adaptation of the CCC, the CCC-2 (Bishop 2003 ). Most pragmatic items clustered together in one factor and these pragmatic items also clustered with items related to social relationships and specific interests. The nine scales of the original CCC do not reflect the underlying factor structure. Therefore, scale composition may be improved on and scores on subscale level need to be interpreted cautiously. Therefore, in interpreting the CCC profiles, the overall measure might be more informative than the postulated subscales as more information is needed to determine which constructs the suggested subscales are actually measuring.

  15. Final Corrective Action Study for the Former CCC/USDA Facility in Hanover, Kansas

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2013-11-01

    Low concentrations of carbon tetrachloride in groundwater and vapor intrusion into a limited number of residences (attributable to the contaminant concentrations in groundwater) have been identified in Hanover, Kansas, at and near a grain storage facility formerly leased and operated by the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA). At the request of the Kansas Department of Health and Environment (KDHE 2009h), the CCC/USDA has prepared this Corrective Action Study (CAS) for the facility. The CAS examines corrective actions to address the contamination in groundwater and soil vapor.

  16. Phase II Investigation at the Former CCC/USDA Grain Storage Facility in Savannah, Missouri

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M. [Argonne National Lab. (ANL), Argonne, IL (United States). Environmental Science Division. Applied Geosciences and Environmental Management Section

    2012-05-01

    From approximately 1949 until 1970, the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) operated a grain storage facility on federally owned property approximately 0.25 mi northwest of Savannah, Missouri. During this time, commercial grain fumigants containing carbon tetrachloride were commonly used by the CCC/USDA and the private grain storage industry to preserve grain in their facilities. In November 1998, carbon tetrachloride was detected in a private well (Morgan) roughly 50 ft south of the former CCC/USDA facility, as a result of statewide screening of private wells near former CCC/USDA facilities, conducted in Missouri by the U.S. Environmental Protection Agency (EPA 1999). The 1998 and subsequent investigations by the EPA and the Missouri Department of Natural Resources (MDNR) confirmed the presence of carbon tetrachloride in the Morgan well, as well as in a second well on property currently owned by the Missouri Department of Transportation (MoDOT), directly east of the former CCC/USDA facility. The identified concentrations in these two wells were above the EPA maximum contaminant level (MCL) and the Missouri risk-based corrective action default target level (DTL) values of 5.0 μg/L for carbon tetrachloride in water used for domestic purposes (EPA 1999; MDNR 2000a,b, 2006). Because the observed contamination in the Morgan and MoDOT wells might be linked to the past use of carbon tetrachloride-based fumigants at its former grain storage facility, the CCC/USDA is conducting an investigation to (1) characterize the source(s), extent, and factors controlling the subsurface distribution and movement of carbon tetrachloride and (2) evaluate the potential risks to human health, public welfare, and the environment posed by the contamination. This work is being performed in accord with an Intergovernmental Agreement established in 2007 between the Farm Service Agency of the USDA and the MDNR, to address carbon tetrachloride

  17. 78 FR 38286 - Notice of Change to the CCC Sugar Purchase and Exchange To Include Certificates of Quota...

    Science.gov (United States)

    2013-06-26

    ... DEPARTMENT OF AGRICULTURE Commodity Credit Corporation Notice of Change to the CCC Sugar Purchase... Credit Corporation. ACTION: Notice. SUMMARY: The Commodity Credit Corporation (CCC) announces the intent... for sugar was projected at 19 percent in the June 2013 USDA World Agricultural Supply and Demand...

  18. 78 FR 79253 - CCC Export Credit Guarantee (GSM-102) Program and Facility Guarantee Program (FGP)

    Science.gov (United States)

    2013-12-27

    ... been worked out in advance of the exporter's application for the payment guarantee. Foreign Financial... country of domicile must provide financial statements in accordance with prevailing accounting standards... smaller U.S. exporters. Changes are also intended to improve CCC's financial management of the program...

  19. Characterizing Frothers through Critical Coalescence Concentration (CCC95-Hydrophile-Lipophile Balance (HLB Relationship

    Directory of Open Access Journals (Sweden)

    Wei Zhang

    2012-08-01

    Full Text Available Frothers are surfactants commonly used to reduce bubble size in mineral flotation. This paper describes a methodology to characterize frothers by relating impact on bubble size reduction represented by CCC (critical coalescence concentration to frother structure represented by HLB (hydrophile-lipophile balance. Thirty-six surfactants were tested from three frother families: Aliphatic Alcohols, Polypropylene Glycol Alkyl Ethers and Polypropylene Glycols, covering a range in alkyl groups (represented by n, the number of carbon atoms and number of Propylene Oxide groups (represented by m. The Sauter mean size (D32 was derived from bubble size distribution measured in a 0.8 m3 mechanical flotation cell. The D32 vs. concentration data were fitted to a 3-parameter model to determine CCC95, the concentration giving 95% reduction in bubble size compared to water only. It was shown that each family exhibits a unique CCC95-HLB relationship dependent on n and m. Empirical models were developed to predict CCC95 either from HLB or directly from n and m. Commercial frothers of known family were shown to fit the relationships. Use of the model to predict D32 is illustrated.

  20. 76 FR 14370 - Information Collection; Representation for CCC and FSA Loans Authorization To File a Financing...

    Science.gov (United States)

    2011-03-16

    ...; Representation for CCC and FSA Loans Authorization To File a Financing Statement AGENCY: Commodity Credit... Commodity Credit Corporation or Farm Service Agency Loans and Authorization To File A Financing Statement... Financing Statement and Related Documents. OMB Control Number: 0560-0215. Expiration Date of Approval...

  1. 7 CFR 1494.801 - Enforcement and termination of agreements with CCC.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Enforcement and termination of agreements with CCC. 1494.801 Section 1494.801 Agriculture Regulations of the Department of Agriculture (Continued... PROGRAMS Export Enhancement Program Operations § 1494.801 Enforcement and termination of agreements with...

  2. A Role for the Host DNA Damage Response in Hepatitis B Virus cccDNA Formation—and Beyond?

    Directory of Open Access Journals (Sweden)

    Sabrina Schreiner

    2017-05-01

    Full Text Available Chronic hepatitis B virus (HBV infection puts more than 250 million people at a greatly increased risk to develop end-stage liver disease. Like all hepadnaviruses, HBV replicates via protein-primed reverse transcription of a pregenomic (pg RNA, yielding an unusually structured, viral polymerase-linked relaxed-circular (RC DNA as genome in infectious particles. Upon infection, RC-DNA is converted into nuclear covalently closed circular (ccc DNA. Associating with cellular proteins into an episomal minichromosome, cccDNA acts as template for new viral RNAs, ensuring formation of progeny virions. Hence, cccDNA represents the viral persistence reservoir that is not directly targeted by current anti-HBV therapeutics. Eliminating cccDNA will thus be at the heart of a cure for chronic hepatitis B. The low production of HBV cccDNA in most experimental models and the associated problems in reliable cccDNA quantitation have long hampered a deeper understanding of cccDNA molecular biology. Recent advancements including cccDNA-dependent cell culture systems have begun to identify select host DNA repair enzymes that HBV usurps for RC-DNA to cccDNA conversion. While this list is bound to grow, it may represent just one facet of a broader interaction with the cellular DNA damage response (DDR, a network of pathways that sense and repair aberrant DNA structures and in the process profoundly affect the cell cycle, up to inducing cell death if repair fails. Given the divergent interactions between other viruses and the DDR it will be intriguing to see how HBV copes with this multipronged host system.

  3. Effect of dietary 15N-CCC on 15N content of meat and eggs of ...

    African Journals Online (AJOL)

    Udo ter Meulen

    the control diet after 11 days of treatment and seven days after withdrawal of .... Similarly, the difference between δ value of the working ... (1975) who found that after 24 hours of oral application of 3 mg/kg CCC per laying ... the same row and with different superscripts differ (P < 0.05). 0. 0,3. 0,6. 0,9 .... Swedish University of.

  4. Tubing modifications for countercurrent chromatography (CCC): Stationary phase retention and separation efficiency.

    Science.gov (United States)

    Englert, Michael; Vetter, Walter

    2015-07-16

    Countercurrent chromatography (CCC) is a separation technique in which two immiscible liquid phases are used for the preparative purification of synthetic and natural products. In CCC the number of repetitive mixing and de-mixing processes, the retention of the stationary phase and the mass transfer between the liquid phases are significant parameters that influence the resolution and separation efficiency. Limited mass transfer is the main reason for peak broadening and a low number of theoretical plates along with impaired peak resolution in CCC. Hence, technical improvements with regard to column design and tubing modifications is an important aspect to enhance mixing and mass transfer. In this study we constructed a crimping tool which allowed us to make reproducible, semi-automated modifications of conventional round-shaped tubing. Six crimped tubing modifications were prepared, mounted onto multilayer coils which were subsequently installed in the CCC system. The stationary phase retention of the tubing modifications were compared to the conventional system with unmodified tubing in a hydrophobic, an intermediate and a hydrophilic two-phase solvent system. Generally, the tubing modifications provided higher capabilities to retain the stationary phase depending on the solvent system and flow rates. In the intermediate solvent system the separation efficiency was evaluated with a mixture of six alkyl p-hydroxybenzoates. The peak resolution could be increased up to 50% with one of the tubing modifications compared to the unmodified tubing. Using the most convincing tubing modification at fixed values for the stationary phase retention, a reasonable comparison to the unmodified tubing was achieved. The peak width could be reduced up to 49% and a strong positive impact at increased flow rates regarding peak resolution and theoretical plate number was observed compared to unmodified tubing. It could be concluded that the tubing modification enhanced the interphase

  5. Gene Therapy for Chronic HBV-Can We Eliminate cccDNA?

    Science.gov (United States)

    Bloom, Kristie; Maepa, Mohube Betty; Ely, Abdullah; Arbuthnot, Patrick

    2018-04-12

    Chronic infection with the hepatitis B virus (HBV) is a global health concern and accounts for approximately 1 million deaths annually. Amongst other limitations of current anti-HBV treatment, failure to eliminate the viral covalently closed circular DNA (cccDNA) and emergence of resistance remain the most worrisome. Viral rebound from latent episomal cccDNA reservoirs occurs following cessation of therapy, patient non-compliance, or the development of escape mutants. Simultaneous viral co-infections, such as by HIV-1, further complicate therapeutic interventions. These challenges have prompted development of novel targeted hepatitis B therapies. Given the ease with which highly specific and potent nucleic acid therapeutics can be rationally designed, gene therapy has generated interest for antiviral application. Gene therapy strategies developed for HBV include gene silencing by harnessing RNA interference, transcriptional inhibition through epigenetic modification of target DNA, genome editing by designer nucleases, and immune modulation with cytokines. DNA-binding domains and effectors based on the zinc finger (ZF), transcription activator-like effector (TALE), and clustered regularly interspaced short palindromic repeat (CRISPR) systems are remarkably well suited to targeting episomal cccDNA. This review discusses recent developments and challenges facing the field of anti-HBV gene therapy, its potential curative significance and the progress towards clinical application.

  6. Final work plan : investigation of potential contamination at the former CCC/USDA grain storage facility in Hanover, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2008-11-19

    The Commodity Credit Corporation (CCC), an agency of the U.S. Department of Agriculture (USDA), operated a grain storage facility at the northeastern edge of the city of Hanover, Kansas, from 1950 until the early 1970s. During this time, commercial grain fumigants containing carbon tetrachloride were in common use by the grain storage industry to preserve grain in their facilities. In February 1998, trace to low levels of carbon tetrachloride (below the maximum contaminant level [MCL] of 5.0 {micro}g/L) were detected in two private wells near the former grain storage facility at Hanover, as part of a statewide USDA private well sampling program that was implemented by the Kansas Department of Health and Environment (KDHE) near former CCC/USDA facilities. In April 2007, the CCC/USDA collected near-surface soil samples at 1.8-2 ft BGL (below ground level) at 61 locations across the former CCC/USDA facility. All soil samples were analyzed by the rigorous gas chromatograph-mass spectrometer analytical method (purge-and-trap method). No contamination was found in soil samples above the reporting limit of 10 {micro}g/kg. In July 2007, the CCC/USDA sampled indoor air at nine residences on or adjacent to its former facility to address the residents concerns regarding vapor intrusion. Low levels of carbon tetrachloride were detected at four of the nine homes. Because carbon tetrachloride found in private wells and indoor air at the site might be linked to historical use of fumigants containing carbon tetrachloride at its former grain storage facility, the CCC/USDA is proposing to conduct an investigation to determine the source and extent of the carbon tetrachloride contamination associated with the former facility. This investigation will be conducted in accordance with the intergovernmental agreement between the KDHE and the Farm Service Agency (FSA) of the USDA. The investigation at Hanover will be performed, on behalf of the CCC/USDA, by the Environmental Science

  7. Final corrective action study for the former CCC/USDA facility in Ramona, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M. (Environmental Science Division)

    2011-04-20

    Past operations at a grain storage facility formerly leased and operated by the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) in Ramona, Kansas, resulted in low concentrations of carbon tetrachloride in groundwater that slightly exceed the regulatory standard in only one location. As requested by the Kansas Department of Health and Environment, the CCC/USDA has prepared a Corrective Action Study (CAS) for the facility. The CAS examines corrective actions to address groundwater impacted by the former CCC/USDA facility but not releases caused by other potential groundwater contamination sources in Ramona. Four remedial alternatives were considered in the CAS. The recommended remedial alternative in the CAS consists of Environmental Use Control to prevent the inadvertent use of groundwater as a water supply source, coupled with groundwater monitoring to verify the continued natural improvement in groundwater quality. The Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) has directed Argonne National Laboratory to prepare a Corrective Action Study (CAS), consistent with guidance from the Kansas Department of Health and Environment (KDHE 2001a), for the CCC/USDA grain storage facility formerly located in Ramona, Kansas. This effort is pursuant to a KDHE (2007a) request. Although carbon tetrachloride levels at the Ramona site are low, they remain above the Kansas Tier 2 risk-based screening level (RBSL) and the U.S. Environmental Protection Agency (EPA) maximum contaminant level (MCL) of 5 {micro}g/L (Kansas 2003, 2004). In its request for the CAS, the KDHE (2007a) stated that, because of these levels, risk is associated with potential future exposure to contaminated groundwater. The KDHE therefore determined that additional measures are warranted to limit future use of the property and/or exposure to contaminated media as part of site closure. The KDHE further requested comparison of at least two corrective

  8. Work Plan: Phase II Investigation at the Former CCC/USDA Grain Storage Facility in Montgomery City, Missouri

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M [Argonne National Lab. (ANL), Argonne, IL (United States)

    2012-05-01

    From September 1949 until September 1966, the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) leased property at the southeastern end of Montgomery City, Missouri, for the operation of a grain storage facility. During this time, commercial grain fumigants containing carbon tetrachloride were commonly used by the CCC/USDA and the private grain storage industry to preserve grain in their facilities.

  9. Immunohistochemical Markers Distinguishing Cholangiocellular Carcinoma (CCC) from Pancreatic Ductal Adenocarcinoma (PDAC) Discovered by Proteomic Analysis of Microdissected Cells.

    Science.gov (United States)

    Padden, Juliet; Ahrens, Maike; Kälsch, Julia; Bertram, Stefanie; Megger, Dominik A; Bracht, Thilo; Eisenacher, Martin; Kocabayoglu, Peri; Meyer, Helmut E; Sipos, Bence; Baba, Hideo A; Sitek, Barbara

    2016-03-01

    Cholangiocellular carcinoma (CCC) and pancreatic ductal adenocarcinoma (PDAC) are two highly aggressive cancer types that arise from epithelial cells of the pancreatobiliary system. Owing to their histological and morphological similarity, differential diagnosis between CCC and metastasis of PDAC located in the liver frequently proves an unsolvable issue for pathologists. The detection of biomarkers with high specificity and sensitivity for the differentiation of these tumor types would therefore be a valuable tool. Here, we address this problem by comparing microdissected CCC and PDAC tumor cells from nine and eleven cancer patients, respectively, in a label-free proteomics approach. The novel biomarker candidates were subsequently verified by immunohistochemical staining of 73 CCC, 78 primary, and 18 metastatic PDAC tissue sections. In the proteome analysis, we found 180 proteins with a significantly differential expression between CCC and PDAC cells (p value 2). Nine candidate proteins were chosen for an immunohistochemical verification out of which three showed very promising results. These were the annexins ANXA1, ANXA10, and ANXA13. For the correct classification of PDAC, ANXA1 showed a sensitivity of 84% and a specificity of 85% and ANXA10 a sensitivity of 90% at a specificity of 66%. ANXA13 was higher abundant in CCC. It presented a sensitivity of 84% at a specificity of 55%. In metastatic PDAC tissue ANXA1 and ANXA10 showed similar staining behavior as in the primary PDAC tumors (13/18 and 17/18 positive, respectively). ANXA13, however, presented positive staining in eight out of eighteen secondary PDAC tumors and was therefore not suitable for the differentiation of these from CCC. We conclude that ANXA1 and ANXA10 are promising biomarker candidates with high diagnostic values for the differential diagnosis of intrahepatic CCC and metastatic liver tumors deriving from PDAC. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  10. Technical justification for a request to reclassify the former CCC/USDA facility at Canada, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2007-12-21

    Contamination in groundwater at Canada, Kansas, was discovered in 1997, during limited private well sampling near former grain storage facilities of the Commodity Credit Corporation, U.S. Department of Agriculture (CCC/USDA). Subsequent investigations by the Kansas Department of Health and Environment (KDHE) confirmed carbon tetrachloride and nitrate concentrations in groundwater above the respective maximum contaminant levels (MCLs) of 5.0 {micro}g/L and 10.0 mg/L. The KDHE investigations identified both the former CCC/USDA grain storage facility and a private grain storage facility as likely sources for the carbon tetrachloride contamination. The CCC/USDA funded extension of a rural water district line to provide a permanent alternate water supply, and the KDHE has conducted long-term monitoring under the State Water Plan. This document presents an analysis of the available information for the Canada site, acquired in previous investigations and the long-term KDHE monitoring. This analysis forms the technical justification for a request to reclassify the former CCC/USDA grain storage facility at Canada as a site requiring no further action under the Intergovernmental Agreement (IGA) between the KDHE and the USDA's Farm Service Agency. The KDHE's long-term water level monitoring results indicate a consistent groundwater flow direction to the east-southeast. Consequently, the wells with the highest overall concentrations of carbon tetrachloride are downgradient from the private grain storage facility but not downgradient from the former CCC/USDA facility. The KDHE criterion for reclassification of a site is that contamination there should not pose an unacceptable risk, on the basis of analytical results for four consecutive, equally timed, sequenced sampling episodes over a period of no less than two years. In seven KDHE sampling events over a period of six years (2001-2007), the concentrations of carbon tetrachloride in the monitoring well on the former

  11. Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation

    Science.gov (United States)

    Tropberger, Philipp; Mercier, Alexandre; Robinson, Margaret; Zhong, Weidong; Ganem, Don E.; Holdorf, Meghan

    2015-01-01

    Chronic hepatitis B virus (HBV) infection affects 240 million people worldwide and is a major risk factor for liver failure and hepatocellular carcinoma. Current antiviral therapy inhibits cytoplasmic HBV genomic replication, but is not curative because it does not directly affect nuclear HBV closed circular DNA (cccDNA), the genomic form that templates viral transcription and sustains viral persistence. Novel approaches that directly target cccDNA regulation would therefore be highly desirable. cccDNA is assembled with cellular histone proteins into chromatin, but little is known about the regulation of HBV chromatin by histone posttranslational modifications (PTMs). Here, using a new cccDNA ChIP-Seq approach, we report, to our knowledge, the first genome-wide maps of PTMs in cccDNA-containing chromatin from de novo infected HepG2 cells, primary human hepatocytes, and from HBV-infected liver tissue. We find high levels of PTMs associated with active transcription enriched at specific sites within the HBV genome and, surprisingly, very low levels of PTMs linked to transcriptional repression even at silent HBV promoters. We show that transcription and active PTMs in HBV chromatin are reduced by the activation of an innate immunity pathway, and that this effect can be recapitulated with a small molecule epigenetic modifying agent, opening the possibility that chromatin-based regulation of cccDNA transcription could be a new therapeutic approach to chronic HBV infection. PMID:26438841

  12. Inhibition of Hepatitis B virus cccDNA replication by siRNA

    International Nuclear Information System (INIS)

    Li Guiqiu; Gu Hongxi; Li Di; Xu Weizhen

    2007-01-01

    The development of an effective therapy for Hepatitis B virus (HBV) infection is still a challenge. Progress in RNA interference (RNAi) has shed slight on developing a new anti-HBV strategy. Here, we present a series of experiments showing a significant reduction in HBV transcripts and replication intermediates in HepG2.2.15 cells by vector-based siRNA targeted nuclear localization signal (NLS) region. More importantly, we showed that siRNA1 markedly inhibited HBV covalently closed circular DNA (cccDNA) replication. Our results indicated that HBV NLS may serve as a novel RNAi target to combat HBV infection, which can enhance anti-HBV efficacy and overcome the drawbacks of current therapies

  13. The Continuum of Conflict and Control Relationship Scale (CCC-RS): Psychometrics for a Measure Designed to Discriminate among Types of Intimate Partner Violence

    Science.gov (United States)

    Carlson, Ryan G.; Rogers, Tiffany L.; Wheeler, Naomi J.; Kelchner, Viki; Griffith, Sandy-Ann M.; Liu, Xun

    2017-01-01

    Intimate partner violence (IPV) classifications have treatment implications for couples. This study tested the psychometrics of the Continuum of Conflict and Control Relationship Scale (CCC-RS) and examined differences between violence severity and CCC-RS scales. A sample of 575 low-income, ethnically diverse participants contributed data. Results…

  14. HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways

    Science.gov (United States)

    Guo, Fang; Zhao, Qiong; Cheng, Junjun; Qi, Yonghe; Su, Qing; Wei, Lai; Li, Wenhui; Chang, Jinhong

    2017-01-01

    Hepatitis B virus (HBV) core protein assembles viral pre-genomic (pg) RNA and DNA polymerase into nucleocapsids for reverse transcriptional DNA replication to take place. Several chemotypes of small molecules, including heteroaryldihydropyrimidines (HAPs) and sulfamoylbenzamides (SBAs), have been discovered to allosterically modulate core protein structure and consequentially alter the kinetics and pathway of core protein assembly, resulting in formation of irregularly-shaped core protein aggregates or “empty” capsids devoid of pre-genomic RNA and viral DNA polymerase. Interestingly, in addition to inhibiting nucleocapsid assembly and subsequent viral genome replication, we have now demonstrated that HAPs and SBAs differentially modulate the biosynthesis of covalently closed circular (ccc) DNA from de novo infection and intracellular amplification pathways by inducing disassembly of nucleocapsids derived from virions as well as double-stranded DNA-containing progeny nucleocapsids in the cytoplasm. Specifically, the mistimed cuing of nucleocapsid uncoating prevents cccDNA formation during de novo infection of hepatocytes, while transiently accelerating cccDNA synthesis from cytoplasmic progeny nucleocapsids. Our studies indicate that elongation of positive-stranded DNA induces structural changes of nucleocapsids, which confers ability of mature nucleocapsids to bind CpAMs and triggers its disassembly. Understanding the molecular mechanism underlying the dual effects of the core protein allosteric modulators on nucleocapsid assembly and disassembly will facilitate the discovery of novel core protein-targeting antiviral agents that can more efficiently suppress cccDNA synthesis and cure chronic hepatitis B. PMID:28945802

  15. HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways.

    Science.gov (United States)

    Guo, Fang; Zhao, Qiong; Sheraz, Muhammad; Cheng, Junjun; Qi, Yonghe; Su, Qing; Cuconati, Andrea; Wei, Lai; Du, Yanming; Li, Wenhui; Chang, Jinhong; Guo, Ju-Tao

    2017-09-01

    Hepatitis B virus (HBV) core protein assembles viral pre-genomic (pg) RNA and DNA polymerase into nucleocapsids for reverse transcriptional DNA replication to take place. Several chemotypes of small molecules, including heteroaryldihydropyrimidines (HAPs) and sulfamoylbenzamides (SBAs), have been discovered to allosterically modulate core protein structure and consequentially alter the kinetics and pathway of core protein assembly, resulting in formation of irregularly-shaped core protein aggregates or "empty" capsids devoid of pre-genomic RNA and viral DNA polymerase. Interestingly, in addition to inhibiting nucleocapsid assembly and subsequent viral genome replication, we have now demonstrated that HAPs and SBAs differentially modulate the biosynthesis of covalently closed circular (ccc) DNA from de novo infection and intracellular amplification pathways by inducing disassembly of nucleocapsids derived from virions as well as double-stranded DNA-containing progeny nucleocapsids in the cytoplasm. Specifically, the mistimed cuing of nucleocapsid uncoating prevents cccDNA formation during de novo infection of hepatocytes, while transiently accelerating cccDNA synthesis from cytoplasmic progeny nucleocapsids. Our studies indicate that elongation of positive-stranded DNA induces structural changes of nucleocapsids, which confers ability of mature nucleocapsids to bind CpAMs and triggers its disassembly. Understanding the molecular mechanism underlying the dual effects of the core protein allosteric modulators on nucleocapsid assembly and disassembly will facilitate the discovery of novel core protein-targeting antiviral agents that can more efficiently suppress cccDNA synthesis and cure chronic hepatitis B.

  16. HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways.

    Directory of Open Access Journals (Sweden)

    Fang Guo

    2017-09-01

    Full Text Available Hepatitis B virus (HBV core protein assembles viral pre-genomic (pg RNA and DNA polymerase into nucleocapsids for reverse transcriptional DNA replication to take place. Several chemotypes of small molecules, including heteroaryldihydropyrimidines (HAPs and sulfamoylbenzamides (SBAs, have been discovered to allosterically modulate core protein structure and consequentially alter the kinetics and pathway of core protein assembly, resulting in formation of irregularly-shaped core protein aggregates or "empty" capsids devoid of pre-genomic RNA and viral DNA polymerase. Interestingly, in addition to inhibiting nucleocapsid assembly and subsequent viral genome replication, we have now demonstrated that HAPs and SBAs differentially modulate the biosynthesis of covalently closed circular (ccc DNA from de novo infection and intracellular amplification pathways by inducing disassembly of nucleocapsids derived from virions as well as double-stranded DNA-containing progeny nucleocapsids in the cytoplasm. Specifically, the mistimed cuing of nucleocapsid uncoating prevents cccDNA formation during de novo infection of hepatocytes, while transiently accelerating cccDNA synthesis from cytoplasmic progeny nucleocapsids. Our studies indicate that elongation of positive-stranded DNA induces structural changes of nucleocapsids, which confers ability of mature nucleocapsids to bind CpAMs and triggers its disassembly. Understanding the molecular mechanism underlying the dual effects of the core protein allosteric modulators on nucleocapsid assembly and disassembly will facilitate the discovery of novel core protein-targeting antiviral agents that can more efficiently suppress cccDNA synthesis and cure chronic hepatitis B.

  17. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

    NARCIS (Netherlands)

    Bartuzi, Paulina; Billadeau, Daniel D.; Favier, Robert; Rong, Shunxing; Dekker, Daphne; Fedoseienko, Alina; Fieten, Hille; Wijers, Melinde; Levels, Johannes H.; Huijkman, Nicolette; Kloosterhuis, Niels; Van der Molen, Henk; Brufau, Gemma; Groen, Albert K.; Elliott, Alison M.; Kuivenhoven, Jan Albert; Plecko, Barbara; Grangl, Gernot; McGaughran, Julie; Horton, Jay D.; Burstein, Ezra; Hofker, Marten H.; van de Sluis, Bart

    2016-01-01

    The low-density lipoprotein receptor (LDLR) plays a pivotal role in clearing atherogenic circulating low-density lipoprotein (LDL) cholesterol. Here we show that the COMMD/CCDC22/CCDC93 (CCC) and the Wiskott-Aldrich syndrome protein and SCAR homologue (WASH) complexes are both crucial for endosomal

  18. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

    NARCIS (Netherlands)

    Bartuzi, Paulina; Billadeau, Daniel D.; Favier, Robert; Rong, Shunxing; Dekker, Daphne; Fedoseienko, Alina; Fieten, Hille; Wijers, Melinde; Levels, Johannes H.; Huijkman, Nicolette; Kloosterhuis, Niels; van der Molen, Henk; Brufau, Gemma; Groen, Albert K.; Elliott, Alison M.; Kuivenhoven, Jan Albert; Plecko, Barbara; Grangl, Gernot; McGaughran, Julie; Horton, Jay D.; Burstein, Ezra; Hofker, Marten H.; van de Sluis, Bart

    The low-density lipoprotein receptor (LDLR) plays a pivotal role in clearing atherogenic circulating low-density lipoprotein (LDL) cholesterol. Here we show that the COMMD/CCDC22/CCDC93 (CCC) and the Wiskott-Aldrich syndrome protein and SCAR homologue (WASH) complexes are both crucial for endosomal

  19. 7 CFR 1486.301 - How is the working relationship established between CCC and the Recipient of program funding?

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false How is the working relationship established between... relationship established between CCC and the Recipient of program funding? (a) FAS will send an approval letter... agreement and submit it to the Director, Marketing Operations Staff, FAS, USDA. The applicant may not be...

  20. Creative contributory contests (CCC) to spur innovation in sexual health: Two cases and a guide for implementation

    Science.gov (United States)

    Zhang, Ye; Kim, Julie A.; Liu, Fengying; Tso, Lai Sze; Tang, Weiming; Wei, Chongyi; Bayus, Barry L.; Tucker, Joseph D.

    2015-01-01

    Sexual health campaigns are often designed “top-down” by public health experts, failing to engage key populations. Using the power of crowdsourcing to shape a “bottom-up” approach, this note describes two creative contributory contests (CCC) to enhance sexual health campaigns. We provide guidance for designing CCCs to improve HIV and other STD testing. PMID:26462186

  1. Effect of Chlorocholine Chloride (CCC on the Plants’ Height and Inulin Content in Jerusalem Artichoke (Helianthus tuberosus L.

    Directory of Open Access Journals (Sweden)

    Mikołaj Wawrzyniak

    2016-11-01

    Full Text Available Jerusalem artichoke (Helianthus tuberosus L. is herbaceous perennial plant rich in inulin and useful source of biomass. Due to its low agricultural requirements and high adaptability, it can provide very high biomass yields even on low quality sites. The plant is used in food industry, bio-fuel production, forage, pharmacy and nutrition. Its tubers accumulate approx. 10-20% of inulin in fresh weight. Currently, the use of the Helianthius tuberosus L. as a potential dietary strategy in patients affected by type 2 Diabetes is challenge. Moreover, deep understanding of the relationship between diet and composition of gut microbiota can bring the new insight in the treatment of inflammatory dependent diseases. The aim of this study was to examine an effect of plant growth retardant Chlorocholine Chloride (CCC on the plants’ height of H. tuberosus and inulin content in the tubers. We examined in the field a procedure for its shoots reduction. Material for the experiment were bought in a Polish commercial company and 528 tubers were planted in field in the middle of April 2014. Then, half of them were sprayed with 0.75% retardant of CCC . Furthermore, every week for 12 following weeks, the plants’ heights were measured. After the vegetation was over, 6 tubers for each treatment were dug out and chemically analyzed for inulin content using High Pressure Size Exclusion Chromatography. After first week of CCC use, 16% decrease of the heights plants was observed. Height of plants sprayed with CCC were significantly different comparing to Control. Weekly growth was significantly  slower in plants sprayed with CCC on first three weeks after applying retardant. Differences in plants height sustain to the end of measurements. Used retardant and its concentration did not affect the inulin content of the tubers.

  2. Final work plan : supplemental upward vapor intrusion investigation at the former CCC/USDA grain storage facility in Hanover, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2008-12-15

    The Commodity Credit Corporation (CCC), an agency of the U.S. Department of Agriculture (USDA), operated a grain storage facility at the northeastern edge of the city of Hanover, Kansas, from 1950 until the early 1970s. During this time, commercial grain fumigants containing carbon tetrachloride were in common use by the grain storage industry to preserve grain in their facilities. In February 1998, trace to low levels of carbon tetrachloride (below the maximum contaminant level [MCL] of 5.0 {micro}g/L) were detected in two private wells near the former grain storage facility at Hanover, as part of a statewide USDA private well sampling program that was implemented by the Kansas Department of Health and Environment (KDHE) near former CCC/USDA facilities. In 2007, the CCC/USDA conducted near-surface soil sampling at 61 locations and also sampled indoor air at nine residences on or adjacent to its former Hanover facility to address the residents concerns regarding vapor intrusion. Low levels of carbon tetrachloride were detected at four of the nine homes. The results were submitted to the KDHE in October 2007 (Argonne 2007). On the basis of the results, the KDHE requested sub-slab sampling and/or indoor air sampling (KDHE 2007). This Work Plan describes, in detail, the proposed additional scope of work requested by the KDHE and has been developed as a supplement to the comprehensive site investigation work plan that is pending (Argonne 2008). Indoor air samples collected previously from four homes at Hanover were shown to contain the carbon tetrachloride at low concentrations (Table 2.1). It cannot be concluded from these previous data that the source of the detected carbon tetrachloride is vapor intrusion attributable to former grain storage operations of the CCC/USDA at Hanover. The technical objective of the vapor intrusion investigation described here is to assess the risk to human health due to the potential for upward migration of carbon tetrachloride and

  3. CCC, Heat Flow and Mass Flow in Liquid Saturated Porous Media

    International Nuclear Information System (INIS)

    Mangold, D.C.; Lippmann, M.J.; Bodvarsson, G.S.

    1982-01-01

    1 - Description of problem or function: The numerical model CCC (conduction-convection-consolidation) solves the heat and mass flow equations for a fully, liquid-saturated, anisotropic porous medium and computes one-dimensional (vertical) consolidation of the simulated systems. The model has been applied to problems in the fields of geothermal reservoir engineering, aquifer thermal energy storage, well testing, radioactive waste isolation, and in situ coal combustion. The code has been validated against analytic solutions for fluid and heat flow, and against a field experiment for underground storage of hot water. 2 - Method of solution: The model employs the Integrated Finite Difference Method (IFDM) in discretizing the saturated porous medium and formulating the governing equations. The sets of equations are sol- ved by an iterative solution technique. The vertical deformation of the medium is calculated using the one-dimensional consolidation theory of Terzaghi. 3 - Restrictions on the complexity of the problem: Maximum of 12 materials. It is assumed that: (a) Darcy's law adequately describes fluid movement through fractured and porous media. (b) The rock and fluid are in thermal equilibrium at any given time. (c) Energy changes due to the fluid compressibility, acceleration and viscous dissipation are neglected. (d) One-dimensional consolidation theory adequately describes the vertical deformation of the medium

  4. Final master work plan : environmental investigations at former CCC/USDA facilities in Kansas, 2002 revision.

    Energy Technology Data Exchange (ETDEWEB)

    Burton, J. C.; Environmental Research

    2003-01-23

    The Commodity Credit Corporation (CCC) of the U.S. Department of Agriculture (USDA) has entered into an interagency agreement with the U.S. Department of Energy (DOE) under which Argonne National Laboratory provides technical assistance for hazardous waste site characterization and remediation for the CCC/USDA. Carbon tetrachloride is the contaminant of primary concern at sites in Kansas where former CCC/USDA grain storage facilities were located. Argonne applies its QuickSite(reg sign) Expedited Site Characterization (ESC) approach to these former facilities. The QuickSite environmental site characterization methodology is Argonne's proprietary implementation of the ESC process (ASTM 1998). Argonne has used this approach at several former CCC/USDA facilities in Kansas, including Agenda, Agra, Everest, and Frankfort. The Argonne ESC approach revolves around a multidisciplinary, team-oriented approach to problem solving. The basic features and steps of the QuickSite methodology are as follows: (1) A team of scientists with diverse expertise and strong field experience is required to make the process work. The Argonne team is composed of geologists, geochemists, geophysicists, hydrogeologists, chemists, biologists, engineers, computer scientists, health and safety personnel, and regulatory staff, as well as technical support staff. Most of the staff scientists are at the Ph.D. level; each has on average, more than 15 years of experience. The technical team works together throughout the process. In other words, the team that plans the program also implements the program in the field and writes the reports. More experienced scientists do not remain in the office while individuals with lesser degrees or experience carry out the field work. (2) The technical team reviews, evaluates, and interprets existing data for the site and the contaminants there to determine which data sets are technically valid and can be used in initially designing the field program. A basic

  5. SIRT3 restricts HBV transcription and replication via epigenetic regulation of cccDNA involving SUV39H1 and SETD1A histone methyltransferases.

    Science.gov (United States)

    Ren, Ji-Hua; Hu, Jie-Li; Cheng, Sheng-Tao; Yu, Hai-Bo; Wong, Vincent Kam Wai; Law, Betty Yuen Kwan; Yang, Yong-Feng; Huang, Ying; Liu, Yi; Chen, Wei-Xian; Cai, Xue-Fei; Tang, Hua; Hu, Yuan; Zhang, Wen-Lu; Liu, Xiang; Long, Quan-Xin; Zhou, Li; Tao, Na-Na; Zhou, Hong-Zhong; Yang, Qiu-Xia; Ren, Fang; He, Lin; Gong, Rui; Huang, Ai-Long; Chen, Juan

    2018-04-06

    Hepatitis B virus (HBV) infection remains a major health problem worldwide. Maintenance of the covalently closed circular DNA (cccDNA) which serves as a template for HBV RNA transcription is responsible for the failure of eradicating chronic HBV during current antiviral therapy. cccDNA is assembled with cellular histone proteins into chromatin, but little is known about the regulation of HBV chromatin by histone posttranslational modifications. In this study, we identified SIRT3 as a host factor restricting HBV transcription and replication by screening seven members of Sirtuin family which is the class III histone deacetylase. Ectopic SIRT3 expression significantly reduced total HBV RNAs, 3.5-kb RNA as well as replicative intermediate DNA in HBV-infected HepG2-NTCP cells and PHH. In contrast, gene silencing of SIRT3 promoted HBV transcription and replication. Mechanistic study found nuclear SIRT3 was recruited to the HBV cccDNA, where it deacetylated histone 3 lysine 9 (H3K9). Importantly, occupancy of SIRT3 onto cccDNA could increase the recruitment of histone methyltransferase SUV39H1 to cccDNA and decrease recruitment of SETD1A, leading to a marked increase of H3K9me3 and a decrease of H3K4me3 on cccDNA. Moreover, SIRT3-mediated HBV cccDNA transcriptional repression involved decreased binding of host RNA polymerase II and transcription factor YY1 to cccDNA. Finally, viral protein HBx could relieve SIRT3-mediated cccDNA transcriptional repression by inhibiting both SIRT3 expression and its recruitment to cccDNA. SIRT3 is a novel host factor epigenetically restricting HBV cccDNA transcription by acting cooperatively with histone methyltransferase. These data provided a rational for the use of SIRT3 activators in the prevention or treatment of HBV infection. This article is protected by copyright. All rights reserved. © 2018 by the American Association for the Study of Liver Diseases.

  6. CERN control centre (CCC) ou de la conception à l'exécution

    CERN Document Server

    Poehler, M

    2005-01-01

    Dès fin 2001, la section Design Office TS-CE est mandatée pour l’étude et la conception d’une nouvelle salle de contrôle des accélérateurs. Après de multiples variantes d’études et d’implantation, la direction CERN retient en début 2004, sur la base de facteurs économiques, le projet CCC, consistant en l’extension et le réaménagement de la PCR existante. Un Working Group TS Infrastructure est mis en place sous le pilotage TS-CE, avec pour objectifs de passer de la phase d’avant projet à la phase de projet définitif et d’étayer la faisabilité technique et économique de cette solution, dans le respect du cahier des charges des utilisateurs. Appuyé sur le rapport d’étude présenté à la direction CERN, cette dernière confirme son feu vert de lancement du projet dans les limites des coûts et des délais présentés. L’ouvrage et son infrastructure technique devant être livrés aux utilisat...

  7. Yağ Gülü (Rosa damascena Mill.’nde Tepe Boşluğu Katı Faz Mikro Ekstraksiyonu (HS-SPME ve Konvansiyonel Su Distilasyonu Yöntemleri ile Elde Edilen Uçucu Bileşenlerin Karşılaştırılması

    Directory of Open Access Journals (Sweden)

    Hasan BAYDAR

    2016-04-01

    Full Text Available Yağ gülü (Rosa damascena Mill., kendine özgü doğal koku bileşenleri nedeniyle parfüm ve kozmetik endüstrisinde değerlendirilen en önemli kokulu gül türüdür. Bu araştırmada, taze yağ gülü çiçeklerinin sepal (çanak yaprak, petal (taç yaprak, stamen (erkek organ ve pistil (dişi organ olarak ayrılan kısımlarının uçucu bileşenleri gaz kromatografisi/kütle spektrometresi (GC-MS ile kombine edilmiş Tepe Boşluğu-Katı Faz Mikro Ekstraksiyon (HS-SPME tekniği ile tespit edilmiştir. Ayrıca taze yağ gülü çiçekleri konvansiyonel hidro-Clevenger su distilasyonu yöntemi ile damıtılmış, elde edilen uçucu yağların bileşenleri GC-MS ile belirlendikten sonra HS-SPME sonuçları ile karşılaştırılmıştır. HS-SPME yönteminin yağ gülünde uçucu bileşenleri analizinde oldukça hassas ve etkili olduğu anlaşılmış, bir yağ gülü çiçeğinin farklı kısımların farklı koku bileşenlerine sahip olduğu belirlenmiştir. Ayrıca su distilasyonu ile elde edilen gül yağının uçucu yağ bileşenlerinin çiçeğin doğal koku bileşenlerinden farklı olduğu ve distilasyon sürecinde önemli bazı bileşenlerde değişimler ve kayıplar olduğu tespit edilmiştir. Taze gül çiçeğinin en önemli bileşeni olan feniletil alkol çiçeğin en fazla pembe renkli petallerinde (taç yapraklarında, gül yağında varlığı istenmeyen metil öjenol ise çiçeğin en fazla stamenlerinde (erkek organlarında bulunduğu belirlenmiştir.

  8. Tıbbi Adaçayı (Salvia officinalis L.’nda Farklı Hasat Zamanlarının Uçucu Yağ ve Fenolik Bileşikler ile Antioksidan Aktivite Üzerine Etkisi

    Directory of Open Access Journals (Sweden)

    Müge BAŞYİĞİT

    2016-11-01

    Full Text Available Bu araştırma, bir yıl süreyle 12 ayı temsil edecek şekilde farklı zamanlarda hasat edilen tıbbi adaçayı (Salvia officinalis L.’nın herba ve yaprak verimi, yaprakların taşıdığı uçucu yağ oranı ve kompozisyonu, ekstrede  Folin-Ciocalteu kolorimetrik metodu kullanılarak toplam fenolik madde miktarı, fenolik bileşikleri, serbest radikal süpürücü aktivitesi (DPPH ve demir iyonu indirgeme gücü (FRAP yöntemlerine göre antioksidan aktivitelerini belirlemek amacıyla yapılmıştır. Tıbbi adaçayında taze herba verimi 500.0-961.0 kg/da, kuru herba verimi 223.4-556.6 kg/da, kuru yaprak verimi 129.6-367.2 kg/da, uçucu yağ oranı %0.83-3.33, toplam fenolik madde miktarı 14.54-30.83 mg/g arasında değişim göstermiştir. Yaz ve güz aylarında hasat edilen bitkilerin herba ve yaprak verimleri, uçucu yağ oranları ve verimleri ile toplam fenolik madde miktarları kış ve bahar aylarında hasat edilen bitkilere göre daha yüksek bulunmuştur. Tıbbi adaçayının uçucu yağ kompozisyonunu oluşturan en önemli bileşenlerin 1,8-sineol (%11.93-31.87, α-tuyon (%15.72-26.26, β-tuyon (%4.51-27.67 ve kamfor (%3.65-23.02 olduğu, 1,8-sineol ve kamfor oranları ilkbahar aylarında daha düşük oranlarda, α- ve β-tuyon oranları ise ilkbahar aylarında daha yüksek oranlarda bulunduğu tespit edilmiştir. Tıbbi adaçayının en önemli fenolik bileşenlerinin ise rosmarinik asit (15.15-100.57 mg/g, naringin (9.59-41.81 mg/g, hesperidin (9.80-53.26 mg/g ve rutin (0.73-10.04 mg/g olduğu, en yüksek antioksidan aktivite Mayıs ve Haziran aylarında biçilen ve en düşük antioksidan aktivite ise Mart ve Nisan aylarında biçilen tıbbi adaçayı yapraklarında gözlenmiştir.

  9. Illicit drug use and abuse/dependence: modeling of two-stage variables using the CCC approach.

    Science.gov (United States)

    Agrawal, A; Neale, M C; Jacobson, K C; Prescott, C A; Kendler, K S

    2005-06-01

    Drug use and abuse/dependence are stages of a complex drug habit. Most genetically informative models that are fit to twin data examine drug use and abuse/dependence independent of each other. This poses an interesting question: for a multistage process, how can we partition the factors influencing each stage specifically from the factors that are common to both stages? We used a causal-common-contingent (CCC) model to partition the common and specific influences on drug use and abuse/dependence. Data on use and abuse/dependence of cannabis, cocaine, sedatives, stimulants and any illicit drug was obtained from male and female twin pairs. CCC models were tested individually for each sex and in a sex-equal model. Our results suggest that there is evidence for additive genetic, shared environmental and unique environmental influences that are common to illicit drug use and abuse/dependence. Furthermore, we found substantial evidence for factors that were specific to abuse/dependence. Finally, sexes could be equated for all illicit drugs. The findings of this study emphasize the need for models that can partition the sources of individual differences into common and stage-specific influences.

  10. Phase I Investigations at the Former CCC/USDA Grain Storage Facility in Montgomery City, Missouri, in 2010-2011

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M. [Argonne National Lab. (ANL), Argonne, IL (United States). Environmental Science Division. Applied Geoscience and Environmental Restoration Program

    2012-11-01

    This report presents the technical findings of Phase I of Argonne’s studies. The Phase I field investigation was initiated on October 18, 2010. The work was conducted in accord with (1) the final site-specific Phase I Work Plan for Montgomery City (Argonne 2010; approved by the MDNR [2010]); (2) applicable Missouri regulations; and (3) the standard operating procedures, quality assurance/quality control (QA/QC) measures, and general health and safety policies outlined in the Master Work Plan (Argonne 2002) for operations in Kansas, which was reviewed by the MDNR and accepted for current use. A draft master plan specific to work in Missouri and a set of draft standard operating procedures are in review with the MDNR. The site-specific Work Plan for Montgomery City (Argonne 2010) (1) summarizes the pre-existing knowledge base for the Montgomery City investigation site compiled by Argonne and (2) describes the site-specific technical objectives and the intended scope of work developed for the first phase of the investigation. Three primary technical objectives were identified for the Phase I studies, as follows: 1. Update the presently identified inventory and status of private and public drinking water wells in the immediate vicinity of the former CCC/USDA grain storage facility, and sample the identified wells for volatile organic compounds (VOCs) and geochemical analyses. In conjunction with this effort, determine the present sources(s) of drinking water for all residents in an approximate 0.5-mi radius of the former CCC/USDA facility. 2. Investigate for possible evidence of a soil source of carbon tetrachloride contamination in the unconsolidated sediments beneath the former CCC/USDA facility that might affect the underlying bedrock aquifer units. 3. Obtain preliminary information on the site-specific lithologic and hydrologic characteristics of the unconsolidated sediments overlying bedrock at the former CCC/USDA grain storage location. Section 2 of this report

  11. Development of "ultrasound-assisted dynamic extraction" and its combination with CCC and CPC for simultaneous extraction and isolation of phytochemicals.

    Science.gov (United States)

    Zhang, Yuchi; Liu, Chunming; Li, Jing; Qi, Yanjuan; Li, Yuchun; Li, Sainan

    2015-09-01

    A new method for the extraction of medicinal herbs termed ultrasonic-assisted dynamic extraction (UADE) was designed and evaluated. This technique was coupled with counter-current chromatography (CCC) and centrifugal partition chromatography (CPC) and then applied to the continuous extraction and online isolation of chemical constituents from Paeonia lactiflora Pall (white peony) roots. The mechanical parameters, including the pitch and diameter of the shaft, were optimized by means of mathematical modeling. Furthermore, the configuration and mechanism of online UADE coupled with CCC and CPC were elaborated. The stationary phases of the two-phase solvent systems from CCC and CPC were utilized as the UADE solution. The extraction solution was pumped into the sample loop and then introduced into the CCC column; the target compounds were eluted with the lower aqueous phase of the two-phase solvent system. During the CCC separation, the extraction solution was continuously fed in the sample loop by turning the ten-port valve; the extraction solution was then pumped into the CPC column and eluted by the mobile phase of the two-phase solvent system mentioned above. When the first cycle of the UADE/CCC/CPC was completed, the second cycle experiment could be carried out, and so on. Four target compounds (albiflorin, benzoylpaeoniflorin, paeoniflorin, and galloylpaeoniflorin) with purities above 94.96% were successfully extracted and isolated online using the two-phase solvent system comprising ethyl acetate-n-butanol-ethanol-water (1:3.5:2:4.5, v/v/v/v). Compared with conventional extraction methods, the instrumental setup of the present method offers the advantages of automation and systematic extraction and isolation of natural products. Crown Copyright © 2015. Published by Elsevier B.V. All rights reserved.

  12. SU-E-T-516: Dosimetric Validation of AcurosXB Algorithm in Comparison with AAA & CCC Algorithms for VMAT Technique.

    Science.gov (United States)

    Kathirvel, M; Subramanian, V Sai; Arun, G; Thirumalaiswamy, S; Ramalingam, K; Kumar, S Ashok; Jagadeesh, K

    2012-06-01

    To dosimetrically validate AcurosXB algorithm for Volumetric Modulated Arc Therapy (VMAT) in comparison with standard clinical Anisotropic Analytic Algorithm(AAA) and Collapsed Cone Convolution(CCC) dose calculation algorithms. AcurosXB dose calculation algorithm is available with Varian Eclipse treatment planning system (V10). It uses grid-based Boltzmann equation solver to predict dose precisely in lesser time. This study was made to realize algorithms ability to predict dose accurately as its delivery for which five clinical cases each of Brain, Head&Neck, Thoracic, Pelvic and SBRT were taken. Verification plans were created on multicube phantom with iMatrixx-2D detector array and then dose prediction was done with AcurosXB, AAA & CCC (COMPASS System) algorithm and the same were delivered onto CLINAC-iX treatment machine. Delivered dose was captured in iMatrixx plane for all 25 plans. Measured dose was taken as reference to quantify the agreement between AcurosXB calculation algorithm against previously validated AAA and CCC algorithm. Gamma evaluation was performed with clinical criteria distance-to-agreement 3&2mm and dose difference 3&2% in omnipro-I'MRT software. Plans were evaluated in terms of correlation coefficient, quantitative area gamma and average gamma. Study shows good agreement between mean correlation 0.9979±0.0012, 0.9984±0.0009 & 0.9979±0.0011 for AAA, CCC & Acuros respectively. Mean area gamma for criteria 3mm/3% was found to be 98.80±1.04, 98.14±2.31, 98.08±2.01 and 2mm/2% was found to be 93.94±3.83, 87.17±10.54 & 92.36±5.46 for AAA, CCC & Acuros respectively. Mean average gamma for 3mm/3% was 0.26±0.07, 0.42±0.08, 0.28±0.09 and 2mm/2% was found to be 0.39±0.10, 0.64±0.11, 0.42±0.13 for AAA, CCC & Acuros respectively. This study demonstrated that the AcurosXB algorithm had a good agreement with the AAA & CCC in terms of dose prediction. In conclusion AcurosXB algorithm provides a valid, accurate and speedy alternative to AAA

  13. Mixed Compound of DCPTA and CCC Increases Maize Yield by Improving Plant Morphology and Up-Regulating Photosynthetic Capacity and Antioxidants.

    Directory of Open Access Journals (Sweden)

    Yongchao Wang

    Full Text Available DCPTA (2-diethylaminoethyl-3, 4-dichlorophenylether and CCC (2-chloroethyltrimethyl- ammonium chloride have a great effect on maize growth, but applying DCPTA individually can promote the increase of plant height, resulting in the rise of lodging percent. Plant height and lodging percent decrease in CCC-treated plants, but the accumulation of biomass reduce, resulting in yield decrease. Based on the former experiments, the performance of a mixture which contained 40 mg DCPTA and 20 mg CCC as active ingredients per liter of solution, called PCH was tested with applying 40mg/L DCPTA and 20mg/L CCC individually. Grain yield, yield components, internode characters, leaf area per plant, plant height and lodging percent as well as chlorophyll content, chlorophyll fluorescence, enzymatic antioxidants, membranous peroxide and organic osmolyte were analyzed in two years (2011 and 2012, using maize hybrid, Zhengdan 958 (ZD 958 at density of 6.75 plants m-2. CCC, DCPTA and PCH were sprayed on the whole plant leaves at 7 expanded leaves stage and water was used as control. Compared to control, PCH significantly increased grain yield (by 9.53% and 6.68% from 2011 to 2012. CCC significantly decreased kernel number per ear (by 6.78% and 5.69% and thousand kernel weight (TKW (by 8.57% and 6.55% from 2011 to 2012. Kernel number per ear and TKW increased in DCPTA-treated and PCH-treated plants, but showed no significant difference between them. In CCC-treated and PCH-treated plants, internode length and plant height decreased, internode diameter increased, resulting in the significant decline of lodging percent. With DCPTA application, internode diameter increased, but internode length and plant height increased at the same time, resulting in the augment of lodging percent. Bending strength and puncture strength were increased by applying different plant growth regulators (PGRs. In PCH-treated plants, bending strength and puncture strength were greater than other

  14. Incentives for Part-Time Faculty to Participate in the Shared Governance Process within the Institution of California Community Colleges (CCC)

    Science.gov (United States)

    Huyck, Kristen J.

    2012-01-01

    The involvement of part-time faculty tends to be even lower than the engagement level of full-time faculty who partake in the system of shared governance in the California Community Colleges (CCC). During a time when state funds are diminishing, there is a projection of retirement for many community college leaders (Fulton-Calkins & Milling,…

  15. Final work plan : Phase I investigation of potential contamination at the former CCC/USDA grain storage facility in Savannah, Missouri.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2007-10-12

    From approximately 1949 until 1970, the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) operated a grain storage facility on federally owned property approximately 0.25 mi northwest of Savannah, Missouri. During this time, commercial grain fumigants containing carbon tetrachloride were commonly used by the CCC/USDA and the private grain storage industry to preserve grain in their facilities. In November 1998, carbon tetrachloride was detected in a private well (Morgan) roughly 50 ft south of the former CCC/USDA facility, as a result of state-wide screening of private wells near former CCC/USDA facilities, conducted in Missouri by the U.S. Environmental Protection Agency (EPA 1999). The 1998 and subsequent investigations by the EPA and the Missouri Department of Natural Resources (MoDNR) confirmed the presence of carbon tetrachloride in the Morgan well, as well as in a second well (on property currently occupied by the Missouri Department of Transportation [MoDOT]), approximately 400 ft east of the former CCC/USDA facility. Carbon tetrachloride concentrations in the Morgan well have ranged from the initial value of 29 {micro}g/L in 1998, up to a maximum of 61 {micro}g/L in 1999, and back down to 22 {micro}g/L in 2005. The carbon tetrachloride concentration in the MoDOT well in 2000 (the only time it was sampled) was 321 {micro}g/L. The concentrations for the two wells are above the EPA maximum contaminant level (MCL) of 5 {micro}g/L for carbon tetrachloride (EPA 1999; MoDNR 2000a,b). Because the observed contamination in the Morgan and MoDOT wells might be linked to the past use of carbon tetrachloride-based grain fumigants at its former grain storage facility, the CCC/USDA will conduct investigations to (1) characterize the source(s), extent, and factors controlling the subsurface distribution and movement of carbon tetrachloride at Savannah and (2) evaluate the health and environmental threats potentially posed by the contamination

  16. SU-E-T-220: Computational Accuracy of Adaptive Convolution (AC) and Collapsed Cone Convolution (CCC) Algorithms in the Presence of Air Gaps

    Energy Technology Data Exchange (ETDEWEB)

    Oyewale, S [Cancer Centers of Southwest Oklahoma, Lawton, OK (United States); Pokharel, S [21st Century Oncology, Naples, FL (United States); Rana, S [ProCure Proton Therapy Center, Oklahoma City, OK (United States)

    2015-06-15

    Purpose: To compare the percentage depth dose (PDD) computational accuracy of Adaptive Convolution (AC) and Collapsed Cone Convolution (CCC) algorithms in the presence of air gaps. Methods: A 30×30×30 cm{sup 3} solid water phantom with two 5cm air gaps was scanned with a CT simulator unit and exported into the Phillips Pinnacle™ treatment planning system. PDDs were computed using the AC and CCC algorithms. Photon energy of 6 MV was used with field sizes of 3×3 cm{sup 2}, 5×5 cm{sup 2}, 10×10 cm{sup 2}, 15×15 cm{sup 2}, and 20×20 cm{sup 2}. Ionization chamber readings were taken at different depths in water for all the field sizes. The percentage differences in the PDDs were computed with normalization to the depth of maximum dose (dmax). The calculated PDDs were then compared with measured PDDs. Results: In the first buildup region, both algorithms overpredicted the dose for all field sizes and under-predicted for all other subsequent buildup regions. After dmax in the three water media, AC under-predicted the dose for field sizes 3×3 and 5×5 cm{sup 2} and overpredicted for larger field sizes, whereas CCC under-predicted for all field sizes. Upon traversing the first air gap, AC showed maximum differences of –3.9%, −1.4%, 2.0%, 2.5%, 2.9% and CCC had maximum differences of −3.9%, −3.0%,–3.1%, −2.7%, −1.8% for field sizes 3×3, 5×5, 10×10, 15×15, and 20×20 cm{sup 2} respectively. Conclusion: The effect of air gaps causes a significant difference in the PDDs computed by both the AC and CCC algorithms in secondary build-up regions. AC computed larger values for the PDDs except at smaller field sizes. For CCC, the size of the errors in prediction of the PDDs has an inverse relationship with respect to field size. These effects should be considered in treatment planning where significant air gaps are encountered.

  17. Final work plan : phase I investigation of potential contamination at the former CCC/USDA grain storage facility in Montgomery City, Missouri.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2010-08-16

    From September 1949 until September 1966, the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) leased property at the southeastern end of Montgomery City, Missouri, for the operation of a grain storage facility. During this time, commercial grain fumigants containing carbon tetrachloride were commonly used by the CCC/USDA and the private grain storage industry to preserve grain in their facilities. In January 2000, carbon tetrachloride was detected in a soil sample (220 {micro}g/kg) and two soil gas samples (58 {micro}g/m{sup 3} and 550 {micro}g/m{sup 3}) collected at the former CCC/USDA facility, as a result of a pre-CERCLIS site screening investigation (SSI) performed by TN & Associates, Inc., on behalf of the U.S. Environmental Protection Agency (EPA), Region VII (MoDNR 2001). In June 2001, the Missouri Department of Natural Resources (MoDNR) conducted further sampling of the soils and groundwater at the former CCC/USDA facility as part of a preliminary assessment/site inspection (PA/SI). The MoDNR confirmed the presence of carbon tetrachloride (at a maximum identified concentration of 2,810 {micro}g/kg) and chloroform (maximum 82 {micro}g/kg) in the soils and also detected carbon tetrachloride and chloroform (42.2 {micro}g/L and 58.4 {micro}g/L, respectively) in a groundwater sample collected at the former facility (MoDNR 2001). The carbon tetrachloride levels identified in the soils and groundwater are above the default target level (DTL) values established by the MoDNR for this contaminant in soils of all types (79.6 {micro}g/kg) and in groundwater (5.0 {micro}g/L), as outlined in Missouri Risk-Based Corrective Action (MRBCA): Departmental Technical Guidance (MoDNR 2006a). The corresponding MRBCA DTL values for chloroform are 76.6 {micro}g/kg in soils of all types and 80 {micro}g/L in groundwater. Because the observed contamination at Montgomery City might be linked to the past use of carbon tetrachloride-based fumigants at its

  18. Quantitation of HBV cccDNA in anti-HBc-positive liver donors by droplet digital PCR: a new tool to detect occult infection.

    Science.gov (United States)

    Caviglia, Gian Paolo; Abate, Maria Lorena; Tandoi, Francesco; Ciancio, Alessia; Amoroso, Antonio; Salizzoni, Mauro; Saracco, Giorgio Maria; Rizzetto, Mario; Romagnoli, Renato; Smedile, Antonina

    2018-04-02

    The accurate diagnosis of occult HBV infection (OBI) requires the demonstration of HBV DNA in liver biopsies of HBsAg-negative subjects. However, in clinical practice a latent OBI is deduced by the finding of the antibody to the HB-core antigen (anti-HBc). We investigated the true prevalence of OBI and the molecular features of intrahepatic HBV in anti-HBc-positive subjects. The livers of 100 transplant donors (median age 68.2 years; 64 males, 36 females) positive for anti-HBc at standard serologic testing, were examined for total HBV DNA by nested-PCR and for the HBV covalently closed circular DNA (HBV cccDNA) with an in-house droplet digital PCR assay (ddPCR) (Linearity: R 2 = 0.9998; lower limit of quantitation and detection of 2.4 and 0.8 copies/10 5 cells, respectively). A true OBI status was found in 52% (52/100) of the subjects and cccDNA was found in 52% (27/52) of the OBI-positive, with a median 13 copies/10 5 cells (95% confidence interval 5-25). Using an assay specific for anti-HBc of IgG class, the median antibody level was significantly higher in HBV cccDNA-positive than negative donors (5.7 [3.6-9.7] vs. 17.0 [7.0-39.2] COI, p = 0.007). By multivariate analysis, an anti-HBc IgG value above a 4.4 cut-off index (COI) was associated with the finding of intrahepatic HBV cccDNA (OR = 8.516, p = 0.009); a lower value ruled out its presence with a negative predictive value of 94.6%. With a new in-house ddPCR-based method, intrahepatic HBV cccDNA was detectable in quantifiable levels in about half of the OBI cases examined. The titer of anti-HBc IgG may be a useful surrogate to predict the risk of OBI reactivation in immunosuppressed patients. The covalently closed circular DNA (cccDNA) form of the Hepatitis B virus (HBV) sustains the persistence of the virus even after decades of resolution of the florid infection (Occult HBV infection=OBI). In the present study we developed an highly sensitive method based on droplet digital PCR technology for the detection

  19. Analysis of alkaptonuria (AKU) mutations and polymorphisms reveals that the CCC sequence motif is a mutational hot spot in the homogentisate 1,2 dioxygenase gene (HGO).

    Science.gov (United States)

    Beltrán-Valero de Bernabé, D; Jimenez, F J; Aquaron, R; Rodríguez de Córdoba, S

    1999-01-01

    We recently showed that alkaptonuria (AKU) is caused by loss-of-function mutations in the homogentisate 1,2 dioxygenase gene (HGO). Herein we describe haplotype and mutational analyses of HGO in seven new AKU pedigrees. These analyses identified two novel single-nucleotide polymorphisms (INV4+31A-->G and INV11+18A-->G) and six novel AKU mutations (INV1-1G-->A, W60G, Y62C, A122D, P230T, and D291E), which further illustrates the remarkable allelic heterogeneity found in AKU. Reexamination of all 29 mutations and polymorphisms thus far described in HGO shows that these nucleotide changes are not randomly distributed; the CCC sequence motif and its inverted complement, GGG, are preferentially mutated. These analyses also demonstrated that the nucleotide substitutions in HGO do not involve CpG dinucleotides, which illustrates important differences between HGO and other genes for the occurrence of mutation at specific short-sequence motifs. Because the CCC sequence motifs comprise a significant proportion (34.5%) of all mutated bases that have been observed in HGO, we conclude that the CCC triplet is a mutational hot spot in HGO. PMID:10205262

  20. A custom correlation coefficient (CCC) approach for fast identification of multi-SNP association patterns in genome-wide SNPs data.

    Science.gov (United States)

    Climer, Sharlee; Yang, Wei; de las Fuentes, Lisa; Dávila-Román, Victor G; Gu, C Charles

    2014-11-01

    Complex diseases are often associated with sets of multiple interacting genetic factors and possibly with unique sets of the genetic factors in different groups of individuals (genetic heterogeneity). We introduce a novel concept of custom correlation coefficient (CCC) between single nucleotide polymorphisms (SNPs) that address genetic heterogeneity by measuring subset correlations autonomously. It is used to develop a 3-step process to identify candidate multi-SNP patterns: (1) pairwise (SNP-SNP) correlations are computed using CCC; (2) clusters of so-correlated SNPs identified; and (3) frequencies of these clusters in disease cases and controls compared to identify disease-associated multi-SNP patterns. This method identified 42 candidate multi-SNP associations with hypertensive heart disease (HHD), among which one cluster of 22 SNPs (six genes) included 13 in SLC8A1 (aka NCX1, an essential component of cardiac excitation-contraction coupling) and another of 32 SNPs had 29 from a different segment of SLC8A1. While allele frequencies show little difference between cases and controls, the cluster of 22 associated alleles were found in 20% of controls but no cases and the other in 3% of controls but 20% of cases. These suggest that both protective and risk effects on HHD could be exerted by combinations of variants in different regions of SLC8A1, modified by variants from other genes. The results demonstrate that this new correlation metric identifies disease-associated multi-SNP patterns overlooked by commonly used correlation measures. Furthermore, computation time using CCC is a small fraction of that required by other methods, thereby enabling the analyses of large GWAS datasets. © 2014 WILEY PERIODICALS, INC.

  1. Final work plan : indoor air and ambient air sampling near the former CCC/USDA grain storage facility in Everest, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M. (Environmental Science Division)

    2010-05-24

    The Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) operated a grain storage facility at the western edge of Everest, Kansas, from the early 1950s to the early 1970s. Sampling by the Kansas Department of Health and Environment (KDHE) in 1997 resulted in the detection of carbon tetrachloride in one domestic well (the Nigh well) northwest of the former facility. On behalf of the CCC/USDA, Argonne National Laboratory subsequently conducted a series of investigations to characterize the contamination (Argonne 2003, 2006a,b,c). Automatic, continuous monitoring of groundwater levels began in 2002 and is ongoing at six locations. The results have consistently indicated groundwater flow toward the north-northwest from the former CCC/USDA property to the Nigh property, then west-southwest from the Nigh property to the intermittent creek. Sitewide periodic groundwater and surface water sampling with analysis for volatile organic compounds (VOCs) began in 2008. Argonne's combined data indicate no significant downgradient extension of contamination since 2000. At present, the sampling is annual, as approved by the KDHE (2009) in response to a plan developed for the CCC/USDA (Argonne 2009). This document presents a plan for collecting indoor air samples in homes located along and adjacent to the defined extent of the carbon tetrachloride contamination. The plan was requested by the KDHE. Ambient air samples to represent the conditions along this pathway will also be taken. The purpose of the proposed work is to satisfy KDHE requirements and to collect additional data for assessing the risk to human health due to the potential upward migration of carbon tetrachloride and its primary degradation product (chloroform) into homes located in close proximity to the former grain storage facility, as well as along and within 100 ft laterally from the currently defined plume emanating from the former Everest facility. Investigation of the indoor air

  2. Progress Report on the ISCR Pilot Test Conducted at the Former CCC/USDA Grain Storage Facility in Montgomery City, Missouri, as of April 2013

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M. [Argonne National Lab. (ANL), Argonne, IL (United States). Environmental Science Division. Applied Geoscience and Environmental Restoration Program

    2013-06-01

    The Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) is conducting an environmental investigation at the former CCC/USDA grain storage facility on the county fairgrounds in Montgomery City, Missouri, to evaluate contamination associated with the former use of grain fumigants containing carbon tetrachloride at the site. The CCC/USDA studies have identified carbon tetrachloride in the soils (primarily unconsolidated glacial tills) at concentrations that exceed the U.S. Environmental Protection Agency (EPA) regional screening level (RSL) values for this compound in residential soils (610 μg/kg) but are below the corresponding RSL for industrial soils (3,000 μg/kg). Concentrations of carbon tetrachloride greater than the EPA maximum contaminant level (MCL; 5.0 μg/L) for this contaminant in drinking water were also identified in the shallow groundwater (Argonne 2012). On the basis of these findings, remedial actions are considered necessary to mitigate the present and potential future impacts of the contamination. In cooperation with the Missouri Department of Natural Resources (MDNR), the CCC/USDA has initiated a field-scale pilot test to evaluate an in situ technology for treatment of the carbon tetrachloride contamination. In this approach, a chemical amendment consisting primarily of slow-release organic matter and zero-valent iron is employed to induce oxygen-depleted, chemically reducing conditions in the subsurface. These conditions foster the in situ chemical reduction (ISCR) of carbon tetrachloride and its degradation products (chloroform, methylene chloride, and chloromethane) via both inorganic and biologically mediated processes. The chemical amendment being used, EHC™, was developed by the Adventus Group, Freeport, Illinois, and is now manufactured and distributed by FMC Environmental Solutions, Philadelphia, Pennsylvania. With the approval of the MDNR (2012), the ISCR technology is being tested in two target areas

  3. Progress report and technical evaluation of the ISCR pilot test conducted at the former CCC/USDA grain storage facility in Centralia, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2009-01-14

    In October, 2007, the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) presented the document Interim Measure Conceptual Design (Argonne 2007a) to the Kansas Department of Health and Environment, Bureau of Environmental Remediation (KDHE/BER), for a proposed non-emergency Interim Measure (IM) at the site of the former CCC/USDA grain storage facility in Centralia, Kansas (Figure 1.1). The IM was recommended to mitigate existing levels of carbon tetrachloride contamination identified in the vadose zone soils beneath the former facility and in the groundwater beneath and in the vicinity of the former facility, as well as to moderate or decrease the potential future concentrations of carbon tetrachloride in the groundwater. The Interim Measure Conceptual Design (Argonne 2007a) was developed in accordance with the KDHE/BER Policy No.BERRS-029, Policy and Scope of Work: Interim Measures (KDHE 1996). The hydrogeologic, geochemical, and contaminant distribution characteristics of the Centralia site, as identified by the CCC/USDA, factored into the development of the nonemergency IM proposal. These characteristics were summarized in the Interim Measure Conceptual Design (Argonne 2007a) and were discussed in detail in previous Argonne reports (Argonne 2002a, 2003, 2004, 2005a,b,c, 2006a,b, 2007b). The identified remedial goals of the proposed IM were as follows: (1) To reduce the existing concentrations of carbon tetrachloride in groundwater in three 'hot spot' areas identified at the site (at SB01, SB05, and SB12-MW02; Figure 1.2) to levels acceptable to the KDHE. (2) To reduce carbon tetrachloride concentrations in the soils near the location of former soil boring SB12 and existing monitoring well MW02 (Figure 1.2) to levels below the KDHE Tier 2 Risk-Based Screening Level (RBSL) of 200 {micro}g/kg for this contaminant. To address these goals, the potential application of an in situ chemical reduction (ISCR) treatment technology

  4. Interim measure conceptual design for remediation at the former CCC/USDA grain storage facility at Centralia, Kansas : pilot test and remedy implementation.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2007-11-09

    This document presents an Interim Measure Work Plan/Design for the short-term, field-scale pilot testing and subsequent implementation of a non-emergency Interim Measure (IM) at the site of the former grain storage facility operated by the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) in Centralia, Kansas. The IM is recommended to mitigate both (1) localized carbon tetrachloride contamination in the vadose zone soils beneath the former facility and (2) present (and potentially future) carbon tetrachloride contamination identified in the shallow groundwater beneath and in the immediate vicinity of the former CCC/USDA facility. Investigations conducted on behalf of the CCC/USDA by Argonne National Laboratory have demonstrated that groundwater at the Centralia site is contaminated with carbon tetrachloride at levels that exceed the Kansas Tier 2 Risk-Based Screening Level (RBSL) and the U.S. Environmental Protection Agency's maximum contaminant level of 5.0 {micro}g/L for this compound. Groundwater sampling and analyses conducted by Argonne under a monitoring program approved by the Kansas Department of Health and Environment (KDHE) indicated that the carbon tetrachloride levels at several locations in the groundwater plume have increased since twice yearly monitoring of the site began in September 2005. The identified groundwater contamination currently poses no unacceptable health risks, in view of the absence of potential human receptors in the vicinity of the former CCC/USDA facility. Carbon tetrachloride contamination has also been identified at Centralia in subsurface soils at concentrations on the order of the Kansas Tier 2 RBSL of 200 {micro}g/kg in soil for the soil-to-groundwater protection pathway. Soils contaminated at this level might pose some risk as a potential source of carbon tetrachloride contamination to groundwater. To mitigate the existing contaminant levels and decrease the potential future concentrations of

  5. Magneto-acoustic properties of UCuGe single crystal

    Czech Academy of Sciences Publication Activity Database

    Yasin, S.; Andreev, Alexander V.; Sytcheva, A.; Wosnitza, J.; Zherlitsyn, S.

    2010-01-01

    Roč. 159, 1-2 (2010), 105-108 ISSN 0022-2291 R&D Projects: GA ČR GA202/09/0339 Grant - others:EuroMagNET(XE) 228043 Institutional research plan: CEZ:AV0Z10100520 Keywords : ultrasound * UTX compounds * pulse fields * field-induced transition Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.403, year: 2010

  6. Comparison of build-up region doses in oblique tangential 6 MV photon beams calculated by AAA and CCC algorithms in breast Rando phantom

    Science.gov (United States)

    Masunun, P.; Tangboonduangjit, P.; Dumrongkijudom, N.

    2016-03-01

    The purpose of this study is to compare the build-up region doses on breast Rando phantom surface with the bolus covered, the doses in breast Rando phantom and also the doses in a lung that is the heterogeneous region by two algorithms. The AAA in Eclipse TPS and the collapsed cone convolution algorithm in Pinnacle treatment planning system were used to plan in tangential field technique with 6 MV photon beam at 200 cGy total doses in Breast Rando phantom with bolus covered (5 mm and 10 mm). TLDs were calibrated with Cobalt-60 and used to measure the doses in irradiation process. The results in treatment planning show that the doses in build-up region and the doses in breast phantom were closely matched in both algorithms which are less than 2% differences. However, overestimate of doses in a lung (L2) were found in AAA with 13.78% and 6.06% differences at 5 mm and 10 mm bolus thickness, respectively when compared with CCC algorithm. The TLD measurements show the underestimate in buildup region and in breast phantom but the doses in a lung (L2) were overestimated when compared with the doses in the two plannings at both thicknesses of the bolus.

  7. Hepatitis B virus DNA quantification with the three-in-one (3io) method allows accurate single-step differentiation of total HBV DNA and cccDNA in biopsy-size liver samples.

    Science.gov (United States)

    Taranta, Andrzej; Tien Sy, Bui; Zacher, Behrend Johan; Rogalska-Taranta, Magdalena; Manns, Michael Peter; Bock, Claus Thomas; Wursthorn, Karsten

    2014-08-01

    Hepatitis B virus (HBV) replicates via reverse transcription converting its partially double stranded genome into the covalently closed circular DNA (cccDNA). The long-lasting cccDNA serves as a replication intermediate in the nuclei of hepatocytes. It is an excellent, though evasive, parameter for monitoring the course of liver disease and treatment efficiency. To develop and test a new approach for HBV DNA quantification in serum and small-size liver samples. The p3io plasmid contains an HBV fragment and human β-actin gene (hACTB) as a standard. Respective TaqMan probes were labeled with different fluorescent dyes. A triplex real-time PCR for simultaneous quantification of total HBV DNA, cccDNA and hACTB could be established. Three-in-one method allows simultaneous analysis of 3 targets with a lower limit of quantification of 48 copies per 20 μl PCR reaction and a wide range of linearity (R(2)>0.99, pDNA samples from HBV infected patients. Total HBV DNA and cccDNA could be quantified in 32 and 22 of 33 FFPE preserved liver specimens, respectively. Total HBV DNA concentrations quantified by the 3io method remained comparable with Cobas TaqMan HBV Test v2.0. The three-in-one protocol allows the single step quantification of viral DNA in samples from different sources. Therefore lower sample input, faster data acquisition, a lowered error and significantly lower costs are the advantages of the method. Copyright © 2014 Elsevier B.V. All rights reserved.

  8. KDHE POroject Code: C6-074-00002: Progress and Monitoring Report for the LBD/SVE/AS System at the Former CCC/USDA Grain Storage Facility, Agra, Kansas, in January-June 2016

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-09-01

    In 2008-2009, to address the carbon tetrachloride contamination detected on its former property, the CCC/USDA implemented a source area cleanup in accord with the document Interim Measure Work Plan/Design for Agra, Kansas (IMWP/D; Argonne 2008). The cleanup involves five large-diameter boreholes (LDBs) coupled with soil vapor extraction (SVE) and air sparge (AS) systems. The work plan was approved by the Kansas Department of Health and Environment (KDHE) in November 2008 (KDHE 2008b), and operation began in May 2009.

  9. KDHE Project Code: C6-074-00002: Progress and Monitoring Report for the LDB/SVE/AS System at the Former CCC/USDA Grain Storage Facility, Agra, Kansas, in January-June 2015

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-09-01

    In 2008-2009, to address the carbon tetrachloride contamination detected on its former property, the CCC/USDA implemented a source area cleanup in accord with the document Interim Measure Work Plan/Design for Agra, Kansas (IMWP/D; Argonne 2008). The cleanup involves five large-diameter boreholes (LDBs) coupled with soil vapor extraction (SVE) and air sparge (AS) systems. The work plan was approved by the Kansas Department of Health and Environment (KDHE) in November 2008 (KDHE 2008b), and operation began in May 2009.

  10. KDHE Project Code: C6-074-00002: Progress and Monitoring Report for the LDB/SVE/AS System at the Former CCC/USDA Grain Storage Facility, Agra, Kansas, in January-June 2013

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine [Argonne National Lab. (ANL), Argonne, IL (United States)

    2014-04-01

    In 2008-2009, to address the carbon tetrachloride contamination detected on its former property, the CCC/USDA implemented a source area cleanup in accord with the document Interim Measure Work Plan/Design for Agra, Kansas (IMWP/D; Argonne 2008). The cleanup involves five large-diameter boreholes (LDBs) coupled with soil vapor extraction (SVE) and air sparging (AS). The work plan was approved by the Kansas Department of Health and Environment (KDHE) in November 2008 (KDHE 2008b), and operation began in May 2009.

  11. KDHE Project Code: C6-074-00002: Progress and Monitoring Report for the LDB/SVE/AS System at the Former CCC/USDA Grain Storage Facility, Agra, Kansas, in July-December 2015

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-02-01

    The Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) operated a grain storage facility at Agra, Kansas, from the 1950s to the early 1970s. No structures remain on the property, and the land is used for agricultural purposes, specifically wheat production. The property is currently owned by the Kyle Railroad Co. and is leased to Mr. Herb VanEaton. The Pro-Ag Marketing grain storage facility is directly south of the former CCC/USDA facility. Quarterly progress reports for October-December 2008, January-March 2009, and April- June 2009 (Argonne 2009a,b,c) provided detailed information regarding construction and startup of the cleanup. Previous periodic monitoring reports (Argonne 2010a,b,c,d, 2011a,b,c, 2012, 2013a,b,c, 2014a,b) have tracked the subsequent progress of the cleanup effort. Data for evaluation of system performance are collected primarily by sampling SVE effluents, soil gas monitoring points, and groundwater wells for analysis for volatile organic compounds (VOCs). Table 1.1 provides a detailed chronological summary of activities during implementation of the cleanup.

  12. A proposal for the alteration of the Law 10438/02 (9648/98), viewing the keeping of mini and micro hydroelectric power plants, as far the sub-rogation is concerning for benefit of the Fuel Consumption Account (CCC); Uma proposta para alteracao da Lei 10.438/02 (9.648/98), visando o resguardo das mini e micro centrais hidreletricas, no que tange a sub-rogacao do beneficio da Conta de Consumo de Combustiveis (CCC)

    Energy Technology Data Exchange (ETDEWEB)

    Tiago Filho, Geraldo L.; Ferrari, Jason T. [CERPCH - Centro Nacional de Referencia para Pequenos Aproveitamentos Hidroenergeticos, Itajuba, MG (Brazil)

    2006-07-01

    Observed the minimum limits of power the SHP and MHP(Mini and Micro hydropower) - in which the generation is subject just for record - and the maximum limits - in which the generation depends on Authorization - the enterprises that promote the reduction of the expenditure of CCC (Conta Consumo de Combustiveis in portuguese) in the isolated electric systems deserve the sub-rogation of the referred counts, disposition consonant contained in art. 18 of the Law no. 10.438, of 26 of April 2002. However, this is an affirmation that brings dubious interpretation to the light of the Right, since the Law above referred says in enterprises with Authorization and does not treat in no moment of those that just need record, only the who does is the Federal Constitution /88, in your art.176, paragraph 4. This way, necessary inclusion is done in the Law of the enterprises with Record, in other words, the ones that have potential lower than 1 MW(MHP), so that these have your legal well defined back-up. (author)

  13. Invasive Management Strategies and Antithrombotic Treatments in Patients With Non-ST-Segment-Elevation Acute Coronary Syndrome in China: Findings From the Improving CCC Project (Care for Cardiovascular Disease in China).

    Science.gov (United States)

    Yang, Qing; Wang, Ying; Liu, Jing; Liu, Jun; Hao, Yongchen; Smith, Sidney C; Huo, Yong; Fonarow, Gregg C; Ma, Changsheng; Ge, Junbo; Taubert, Kathryn A; Morgan, Louise; Guo, Yang; Wang, Wei; Zhou, Yujie; Zhao, Dong

    2017-06-01

    Early invasive strategies and antithrombotic treatments are key treatments of non-ST-segment-elevation acute coronary syndrome (NSTE-ACS). Few studies have examined the use of these strategies in patients with NSTE-ACS in China. This study aimed to assess the applications of invasive strategies and antithrombotic treatments in patients with NSTE-ACS and compare their outcomes. A nationwide registry study, Improving CCC (Care for Cardiovascular Disease in China) ACS project, was launched in 2014 as a collaborative study of the American Heart Association and Chinese Society of Cardiology (CSC), with 142 participating hospitals reporting details of clinical management and outcomes of patients with NSTE-ACS. The use of invasive strategies and antithrombotic treatments was examined based on updated guidelines. Major adverse cardiovascular events were analyzed. A total of 9953 patients with NSTE-ACS were enrolled. Angiography was performed in 63.1% of these patients, and 58.2% underwent percutaneous coronary intervention (PCI). However, 40.6% of patients did not undergo early risk assessment, and very-high-risk patients had the lowest proportion of PCI (41.7%). PCI was performed within recommended times in 11.1% of very-high-risk patients and 26.3% of high risk patients. Those who underwent PCI within 2 hours had higher mortality in high-risk and very-high-risk patients who received PCI. Early dual antiplatelet treatment was given in 88.3% of patients. There are notable differences between guideline recommendations and the clinical management of patients with NSTE-ACS in China. The reasons for very-high-risk NSTE-ACS patients not undergoing PCI, and the optimal timing of PCI, require further clarification. URL: http://www.clinicaltrials.gov. Unique identifier: NCT02306616. © 2017 American Heart Association, Inc.

  14. Technical infrastructure monitoring from the CCC

    CERN Document Server

    Stowisek, J; Suwalska, A; CERN. Geneva. TS Department

    2005-01-01

    In the summer of 2005, the Technical Infrastructure Monitoring (TIM) system will replace the Technical Data Server (TDS) as the monitoring system of CERN’s technical services. Whereas the TDS was designed for the LEP, TIM will have to cope with the much more extensive monitoring needs of the LHC era. To cater for this, the new system has been built on industry-standard hardware and software components, using Java 2 Enterprise Edition (J2EE) technology to create a highly available, reliable, scalable and flexible control system. A first version of TIM providing the essential functionality will be deployed in the MCR in June 2005. Additional functionality and more sophisticated tools for system maintenance will be ready before the start-up of the LHC in 2007, when CERN’s technical infrastructure will be monitored from the future CERN Control Centre.

  15. High field magnetism and magnetoacoustics in UCu.sub.0.95./sub.Ge

    Czech Academy of Sciences Publication Activity Database

    Zvyagin, A.A.; Yasin, S.; Skourski, Y.; Andreev, Alexander V.; Zherlitsyn, S.; Wosnitza, J.

    2012-01-01

    Roč. 528, JUL (2012), s. 51-57 ISSN 0925-8388 R&D Projects: GA ČR GAP204/12/0150 Grant - others:EuroMagNET(XE) 228043 Institutional research plan: CEZ:AV0Z10100520 Keywords : uranium intermetallics * single crystals * antiferromagnetism * high fields * acoustics * magnetoelasticity Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.390, year: 2012

  16. Occurence of non-Fermi-liquid behaviour in the f electron systems Ce1-xLaxNi9Ge4, UCu5-xPdx and UCu9Sn4

    International Nuclear Information System (INIS)

    Killer, U.

    2005-01-01

    In the present thesis the experimental determination of lattice parameters, electrical conductivity, magnetic susceptibility, and specific heat of the named substances at ultralow temperatures is described. (HSI)

  17. New data on the Hyrkkoelae U-Cu mineralization: the behaviour of native copper in a natural environment

    Energy Technology Data Exchange (ETDEWEB)

    Marcos, N. [Helsinki Univ. of Technology, Espoo (Finland); Ahonen, L. [Geological Survey of Finland, Helsinki (Finland)

    1999-05-01

    The Hyrkkoelae Cu-U mineralisation (SW Finland) is studied as an analogue to the behaviour of copper canister in crystalline bedrock. Uranium-native copper and uranium-copper corrosion products interactions are also addressed in this study. The integration of uranium series disequilibrium (USD) studies gives an estimate of the time-scales of the corrosion processes. The mineral assemblages native copper-copper sulfide, copper sulfides - copper iron sulfides, and native copper-copper oxide (cuprite) occur in open fractures at several depth intervals within granite pegmatites (GP). The surfaces of these open fractures have accumulations of uranophane crystals and other unidentified uranyl compounds. The secondary uranium minerals are mainly distributed around copper sulfide grains. Microscopic intergrowths of copper sulfides and uranyl compounds also have been observed. The surface of the fracture where native copper and cuprite occur is covered with uranium-rich smectite. The very low {sup 234}U/{sup 238}U activity ratio (0.29 - 0.39) in the main uranium fraction in smectite indicates chemical stable conditions (e.g., oxidising) during at least a time period comparable to the half-life of the {sup 234}U isotope (T{sub 1/2} = 2.44 x 10{sup 5} a). Groundwater samples were collected from intervals where copper minerals occur within open fractures. The Eh and pH conditions were measured during long-term pumping (2-4 weeks per sample). Eh was measured both in situ and an the surface using three electrodes (Pt, Au, C). The actual groundwater conditions are oxidising and would not allow the sulfidization of native copper. Sulfidization may be considered as on old phenomenon, older than the precipitation of uranyl phases in the samples. The end of sulfidization may be earlier than the precipitation and/or remobilisation of U(VI) phases in a time span from about 2 x 10{sup 5} years (precipitation of uranophane) to 2.44 x 10{sup 5} (remobilisation of U from smectite). (orig.)

  18. New data on the Hyrkkoelae U-Cu mineralization: the behaviour of native copper in a natural environment

    International Nuclear Information System (INIS)

    Marcos, N.; Ahonen, L.

    1999-05-01

    The Hyrkkoelae Cu-U mineralisation (SW Finland) is studied as an analogue to the behaviour of copper canister in crystalline bedrock. Uranium-native copper and uranium-copper corrosion products interactions are also addressed in this study. The integration of uranium series disequilibrium (USD) studies gives an estimate of the time-scales of the corrosion processes. The mineral assemblages native copper-copper sulfide, copper sulfides - copper iron sulfides, and native copper-copper oxide (cuprite) occur in open fractures at several depth intervals within granite pegmatites (GP). The surfaces of these open fractures have accumulations of uranophane crystals and other unidentified uranyl compounds. The secondary uranium minerals are mainly distributed around copper sulfide grains. Microscopic intergrowths of copper sulfides and uranyl compounds also have been observed. The surface of the fracture where native copper and cuprite occur is covered with uranium-rich smectite. The very low 234 U/ 238 U activity ratio (0.29 - 0.39) in the main uranium fraction in smectite indicates chemical stable conditions (e.g., oxidising) during at least a time period comparable to the half-life of the 234 U isotope (T 1/2 = 2.44 x 10 5 a). Groundwater samples were collected from intervals where copper minerals occur within open fractures. The Eh and pH conditions were measured during long-term pumping (2-4 weeks per sample). Eh was measured both in situ and an the surface using three electrodes (Pt, Au, C). The actual groundwater conditions are oxidising and would not allow the sulfidization of native copper. Sulfidization may be considered as on old phenomenon, older than the precipitation of uranyl phases in the samples. The end of sulfidization may be earlier than the precipitation and/or remobilisation of U(VI) phases in a time span from about 2 x 10 5 years (precipitation of uranophane) to 2.44 x 10 5 (remobilisation of U from smectite). (orig.)

  19. Reconstruction de la PCR/CCC - French version only

    CERN Multimedia

    2004-01-01

    La salle de contrôle PCR sur le site de Prévessin va être entièrement reconstruite pour accueillir la nouvelle salle de contrôle commune. Un nombre important d'équipements (tables, chaises, consoles en bois, armoire anti-feu, écrans CRT, ...) ne sera plus utilisé après le mois de décembre 2004. Les personnes intéressées par un tel équipement au titre d'une utilisation CERN sont invitées à contacter Claes Frisk (email ou 75170) ou Pierre Charrue (email ou 75410).

  20. Dichlorvos’un (DDVP Allium cepa L. Kök Ucu Meristem Hücrelerinde Mitoz Bölünme ve Kromozomlar Üzerine Etkileri

    Directory of Open Access Journals (Sweden)

    Hatice Soykan

    2014-06-01

    Full Text Available Özet. Çalışmamızda, DDVP’nin A. cepa’da kök uzunluğu, kök sayısı, mitoz bölünme ve kromozomlar üzerine olan etkileri araştırılmıştır. DDVP’nin 2ml/L, 4ml/L, 6 ml/L dozları 12, 24 ve 48 saat olmak üzere üç farklı süre ile A. cepa bitkisinin köklerine uygulanmıştır. Uygulama sonucu her soğandaki kökler sayılmış ve kök uzunlukları ölçülmüştür. Yapılan değerlendirmeler sonucu kontrol gruplarına göre uygulama gruplarının kök sayısının süreye bağlı olarak azalma gösterdiği görülmüştür. Uygulama gruplarının kök uzunlukları kontrol grupları ile karşılaştırıldıklarında uzunluğun genellikle doz ve süreye bağlı olarak azalma gösterdiği belirlenmiştir. Mikroskobik gözlemler sonucu elde edilen veriler tablolara aktarılmış ve SPSS 12.0 programında yapılan istatistiksel analizler ile sonuçlar değerlendirilmiştir. Elde edilen verilere göre DDVP’nin A.cepa bitkisinin köklerinde mitotik indeksi azalttığı saptanmıştır. Mitotik indeksin azalması süre artışına bağlı bir paralellik gösterirken, doz artışına bağlı bir paralellik göstermemektedir. İnsektisitin A.cepa bitkisinin köklerine uygulanması sonucu kromozomlarda hasarlar meydana gelmiştir. En fazla gözlenen kromozom hasarları yapışkanlık, yanlış kutuplaşma ve fragment oluşumudur. Bundan başka anafaz köprüsü ve mikronükleus oluşumları da görülmüştür. Abstract. In our study, effects of DDVP on A.cepa root length, root number, mitosis and chromosomes are determined.  Different doses of DDVP (2ml/L, 4 ml/L, 6 ml/L were applied to A. cepar oots with three different application periods (12h, 24h, 48h. Roots of tubers were counted and root lengths were measured after applications. Our results show that root numbers of application groups are decreased correlated with application time. When root length of application groups with control group is compared, root length decrease is generally seems to be correlated with application dosage and time. The data of microscobical observations were put in tables and evaluated with statistical analysis using SPSS 12.0. DDVP is determined to have a decreasing effect on mitoticindex of A. cepa .Decrease of mitotic index is correlated within crease of application time but not cerrelated with increase in appplication dosage. Chromosme aberrations were occured in A. cepa roots, after application of insecticide. Most observed chromosome defects are stickiness, pole deviation and fragmentation. Anaphase bridges and micro nuclei are also observed.

  1. KANADA’DA YETİŞEN İKİ Thuja L. (CUPRESSACEAE) TÜRÜNÜN UÇUCU YAĞ KOMPOZİSYONU

    OpenAIRE

    KILIÇ, Ömer

    2014-01-01

    Kanada’da yetişen Thuja occidentalis L. ve Tetraclinis articulate (Vahl) Masters (synonym: Thuja articulate) türlerinin ibrelerinden elde edilen yağlar HS-SPME / GC-MS tekniği ile analiz  edildi. Sırasıyla %92.30 and %93.42’lik toplam yağ miktarında otuzbir ve ellibir bileşen tespit edildi. Thuja occidentalis’in ana bileşenleri bornilasetat (%30.00), limonen (%7.56), kamfor (%7.33), α-pinen (%7.18) ve δ-kadinen (%6.01) olarak belirlendi; Tetraclinis articulata’da ise α pinen (%32.67), 3-karen...

  2. Occurence of non-Fermi-liquid behaviour in the f electron systems Ce{sub 1-x}La{sub x}Ni{sub 9}Ge{sub 4}, UCu{sub 5-x}Pd{sub x} and UCu{sub 9}Sn{sub 4}; Auftreten von Nicht-Fermi-Fluessigkeitsverhalten in den f-Elektronen-Systemen Ce{sub 1-x}La{sub x}Ni{sub 9}Ge{sub 4}, UCu{sub 5-x}Pd{sub x} und UCu{sub 9}Sn{sub 4}

    Energy Technology Data Exchange (ETDEWEB)

    Killer, U.

    2005-07-01

    In the present thesis the experimental determination of lattice parameters, electrical conductivity, magnetic susceptibility, and specific heat of the named substances at ultralow temperatures is described. (HSI)

  3. Pressure and magnetic field effects in heavy-fermion UCu.sub.3.5./sub.Al.sub.1.5./sub..

    Czech Academy of Sciences Publication Activity Database

    Nasreen, F.; Kothapalli, K.; Nakotte, H.; Alsmadi, A.M.; Zapf, V.; Fabris, F.; Lacerda, A.; Kamarád, Jiří

    2009-01-01

    Roč. 105, č. 7 (2009), 07E112/1-07E112/3 ISSN 0021-8979 R&D Projects: GA ČR GA202/09/1027 Institutional research plan: CEZ:AV0Z10100521 Keywords : aluminium alloys * copper alloys * crystallisation * heavy fermion systems * high-pressure effects * long-range order * magnetic field effects * magnetoresis Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.072, year: 2009

  4. Strategies for Faith Engagement within One's Career: The Role of Uganda Christian University in Preparing Students for Postgraduation Life

    Science.gov (United States)

    Rugyendo, Medard

    2015-01-01

    This article examines the role of Uganda Christian University (UCU) in devising strategies for the sustenance of Christian faith in one's career for the betterment of the society despite its social ills. The current theme of UCU is "A Complete Education for a Complete Person." As a Christian university, UCU seeks to provide a positive…

  5. SPACE SHUTTLE STS-134 CREW VISITS THE CCC Oct 15, 2009.

    CERN Multimedia

    Maximilien Brice

    2009-01-01

    From left to right, standing: Mission Specialists Mike Fincke (USAF Colonel), Allison Bolinger (NASA training engineer), flight director Derek Hassmann (NASA), Pilot Gregory Johnson (USAF), professor Sam Ting (AMS spokesperson), Paul Collier (CERN Beams department leader), mission specialist Andrew Feustel (NASA). sitting: flight director Gary Horlache (NASA), Mission Specialist Gregory Chamitoff ( NASA), Commander Mark Kelly (US Navy), Steve Myers (CERN, Director for Accelerators), Mission Specialist Colonel Roberto Vittori (ESA and ASI).

  6. Complete ccc Boolean algebras, the order sequential topology, and a problem of von Neumann

    Czech Academy of Sciences Publication Activity Database

    Balcar, Bohuslav; Jech, Thomas; Pazák, Tomáš

    2005-01-01

    Roč. 37, č. 6 (2005), s. 885-898 ISSN 0024-6093 Institutional research plan: CEZ:AV0Z10750506; CEZ:AV0Z10190503 Keywords : Boolean algebras * Maharam submeasure * weak distributivity * independent reals Subject RIV: BA - General Mathematics Impact factor: 0.477, year: 2005

  7. Complete CCC Boolean Algebras, the order Sequential Topology, and a Problem of von Neumann

    Czech Academy of Sciences Publication Activity Database

    Balcar, Bohuslav; Jech, Thomas; Pazák, Tomáš

    2005-01-01

    Roč. 37, č. 6 (2005), s. 885-898 ISSN 0024-6093 R&D Projects: GA ČR(CZ) GA201/02/0857; GA ČR(CZ) GA201/03/0933 Institutional research plan: CEZ:AV0Z10190503 Keywords : Boolean algebra * Maharam submeasure * weak distributivity Subject RIV: BA - General Mathematics Impact factor: 0.477, year: 2005

  8. Targeting estimation of CCC-GARCH models with infinite fourth moments

    DEFF Research Database (Denmark)

    Pedersen, Rasmus Søndergaard

    . In this paper we consider the large-sample properties of the variance targeting estimator for the multivariate extended constant conditional correlation GARCH model when the distribution of the data generating process has infinite fourth moments. Using non-standard limit theory we derive new results...... for the estimator stating that its limiting distribution is multivariate stable. The rate of consistency of the estimator is slower than √Τ (as obtained by the quasi-maximum likelihood estimator) and depends on the tails of the data generating process....

  9. Consenso Iberoamericano sobre un Core Curriculum de Competencias Comunicacionales (CCC) para estudiantes de medicina.

    OpenAIRE

    García de Leonardo Mena, Cristina

    2016-01-01

    A diferencia de las iniciativas desarrolladas en otros entornos culturales y lingüísticos (germánico, británico, europeo, norteamericano,…) hasta la fecha no existe ninguna propuesta propia de los países de habla española y portuguesa (Iberoamérica, Portugal y España) sobre las competencias comunicacionales necesarias para el ejercicio de la medicina. En respuesta a este vacío, el presente proyecto pretende alcanzar un consenso de ámbito iberoamericano sobre el perfil de compet...

  10. CERN Control Centre (CCC) - Collision tests at record-breaking energy of 13 TeV

    CERN Multimedia

    Brice, Maximilien

    2015-01-01

    during the night of 20 May, protons collided in the Large Hadron Collider (LHC) at the record-breaking energy of 13 TeV for the first time. These pictures show the LHC operations team on the morning of 21 of May.

  11. 7 CFR 1486.403 - What expenditures may CCC reimburse under the program?

    Science.gov (United States)

    2010-01-01

    ... budget, excluding indirect costs. Market development cooperators, state regional trade groups, for-profit..., dinner, and refreshments when part of an approved overseas trade activity; miscellaneous courtesies such.... Equipment rentals must be returned by the Recipient to the supplier in accordance with the lease agreements...

  12. A double base change in alternate base pairs induced by ultraviolet irradiation in a glycine transfer RNA gene

    International Nuclear Information System (INIS)

    Coleman, R.D.; Dunst, R.W.; Hill, C.W.; Pennsylvania State Univ., Hershey

    1980-01-01

    The glyUsusub(AGA) mutation affects Escherichia coli tRNAsup(Gly)sub(GGG), changing it to an AGA missense suppressor tRNA. Sequence studies have shown that the mutation involves a double base substitution at the first and third positions of the tRNA anticodon, the result being a change in the anticodon from CCC to UCU. A system has been developed to facilitate the detection of this novel mutation, and we have shown that ultraviolet irradiation and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) are effective in causing the double base change. A single observation of the mutation occuring spontaneously has been made also. The frequency of MNNG-induced glyUsusub(AGA) mutations is compatible with their being caused by two separate mutagenic events. The frequency of UV-induced glyUsusub(AGA) mutations, however, strongly suggests that the occurence of one base substitution strongly enhances the chance of finding the second substitution at the alternate position. In addition to the double change in the anticodon, the glyUsusub(AGA) tRNA differs from tRNAsup(gly)sub(GGG) in that it bears a modification of the A adjacent to the 3' position of the anticodon. Most likely, this modified base is N-[9-(β-D-ribofuranosyl)-purin-6-ylcarbamoyl] threonine. (orig.) 891 AJ/orig. 892 BRE [de

  13. Masses and Regge trajectories of triply heavy Ω{sub ccc} and Ω{sub bbb} baryons

    Energy Technology Data Exchange (ETDEWEB)

    Shah, Zalak; Rai, Ajay Kumar [Sardar Vallabhbhai National Institute of Technology, Department of Applied Physics, Surat, Gujarat (India)

    2017-10-15

    The excited state masses of triply charm and triply bottom Ω baryons are exhibited in the present study. The masses are computed for 1S-5S, 1P-5P, 1D-4D and 1F-2F states in the Hypercentral Constituent Quark Model (hCQM) with the hyper Coulomb plus linear potential. The triply charm/bottom baryon masses are experimentally unknown so that the Regge trajectories are plotted using computed masses to assign the quantum numbers of these unknown states. (orig.)

  14. A biocompatible micro cell culture chamber (mu CCC) for the culturing and on-line monitoring of eukaryote cells

    DEFF Research Database (Denmark)

    Stangegaard, Michael; Petronis, Sarunas; Jørgensen, Anders Michael

    2006-01-01

    culture chip compared to cell culture flasks. The cell culture chip could without further modification support cell growth of two other cell lines. Light coming from the microscope lamp during optical recordings of the cells was the only external factor identified, that could have a negative effect...... on cell survival. Low grade light exposure was however compatible with optical recordings as well as cell viability. These results strongly indicate that a cell culture chip could be constructed that allowed for on-line optical recording of cellular events without affecting the cell culturing condition...

  15. A biocompatible micro cell culture chamber (microCCC) for the culturing and on-line monitoring of eukaryote cells

    DEFF Research Database (Denmark)

    Stangegaard, Michael; Petronis, Sarunas; Jørgensen, A M

    2006-01-01

    culture chip compared to cell culture flasks. The cell culture chip could without further modification support cell growth of two other cell lines. Light coming from the microscope lamp during optical recordings of the cells was the only external factor identified, that could have a negative effect...... on cell survival. Low grade light exposure was however compatible with optical recordings as well as cell viability. These results strongly indicate that a cell culture chip could be constructed that allowed for on-line optical recording of cellular events without affecting the cell culturing condition...

  16. The C-C-C bending modes of PAHs : a new emission plateau from 15 to 20 mu m

    NARCIS (Netherlands)

    Van Kerckhoven, C; Hony, S; Peeters, E; Tielens, A. G. G. M.; Allamandola, LJ; Hudgins, DM; Cox, P; Roelfsema, PR; Voors, RHM; Waelkens, C; Waters, LBFM; Wesselius, PR

    We have obtained 2.5-45 mu m spectra of a sample of compact H II regions, YSOs and evolved stars in order to study the origin and evolution of interstellar Polycyclic Aromatic Hydrocarbon molecules (PAHs). Besides the well-known, strong PAH bands at 3.3, 6.2, 7.7, 8.6, and 11.2 mu m, these spectra

  17. The CCC2000 Birth Cohort Study of Register-Based Family History of Mental Disorders and Psychotic Experiences in Offspring

    DEFF Research Database (Denmark)

    Jeppesen, Pia; Tidselbak Larsen, Janne; Clemmensen, Lars

    2015-01-01

    in childhood was predicted by a family history of mental disorder with psychosis rather than a family history of nonpsychotic mental disorder and whether this association differed by severity of PE. The study examined data on 1632 children from a general population birth cohort assessed at age 11-12 years...... by use of a semistructured interview covering 22 psychotic symptoms. The Danish national registers were linked to describe the complete family history of hospital-based psychiatric diagnoses. Uni- and multivariable logistic regressions were used to test whether a family history of any mental disorder...... with psychosis, or of nonpsychotic mental disorder, vs no diagnoses was associated with increased risk of PE in offspring (hierarchical exposure variable). The occurrence of PE in offspring was significantly associated with a history of psychosis among the first-degree relatives (adjusted relative risk [RR] = 3...

  18. Mandolesi, Reno (INAF IASF Bologna) give a talk about the Planck Mission at CERN. Photo taken in the CCC.

    CERN Multimedia

    Maximilien Brice

    2009-01-01

    The European Space Agency’s Planck satellite, launched the 14th of May 2009, is the next-generation space experiment in the field of Cosmic Microwave Background (CMB) research. It will image the anisotropies of the CMB over the whole sky, with unprecedented sensitivity and angular resolution. Planck will provide a major source of information relevant to many fundamental cosmological problems and will test current theories of the early evolution of the universe and the origin of structure. It will also address a wide range of areas of astrophysical research related to the our Galaxy as well as external galaxies and clusters of galaxies. The ability of Planck to measure polarization across a wide frequency range (30-350 GHz), with high precision and accuracy, and over the whole sky, will provide unique insight not only into specific cosmological questions, but also into the properties of the interstellar medium. This paper is part of a larger package which describes the technical capabilities of the Planck sc...

  19. Opto-electronic scanning of colour pictures with P/sup 2/CCC-all solid state line sensors

    Energy Technology Data Exchange (ETDEWEB)

    Damann, H; Rabe, G; Zinke, M; Herrmann, M; Imjela, R; Laasch, I; Mueller, J; Neumann, K; Tauchen, G; Woelber, J

    1982-04-01

    A new one-chip all solid state line sensor (P/sup 2/CCD-Tricoli) has been realized as a basis for the opto-electronic scanning of colour pictures. The three photosensitive lines for the colour components red, green and blue contain each 652 photo elements. They are arranged in parallel on one silicon crystal, with distances of some 100 ..mu..m. The line sensor is supplied with an extra designed driving circuitry and a signal processing. For colour splitting a colour separating digital phase grating has been developed which generates the three colour components in its three central diffraction orders. Using all the development components ('Tricoli'-line-sensor, electronic circuitry, colour separation grating) a model of a slide scanner has been built up, which succesfully demonstrates the feasibility of the proposed colour scanning system.

  20. Parental-reported health anxiety symptoms in 5- to 7-year old children: The Copenhagen Child Cohort CCC 2000

    DEFF Research Database (Denmark)

    Rask, Charlotte Ulrikka; Elberling, Hanne; Skovgaard, Anne Mette

    2012-01-01

    Hypochondriasis, now often designated as health anxiety, is important in terms of prevalence, levels of suffering, and health services cost in adults. Whereas the DSM-IV-TR suggests that the condition primarily begins in adulthood, retrospective reports point to a possible origin in childhood wit...

  1. Continental rift-setting and evolution of Neoproterozoic Sindreth ...

    Indian Academy of Sciences (India)

    Stefan Schöbel

    2017-09-05

    Sep 5, 2017 ... evolution; a period of global scale plate break-up .... Provenance analysis of LCU and UCU. The left column shows thin ... analysis allows the determination of principal .... ity, partly even in the sub-meter scale, between.

  2. High Frequency Acoustic Propagation using Level Set Methods

    Science.gov (United States)

    2007-01-01

    solution of the high frequency approximation to the wave equation. Traditional solutions to the Eikonal equation in high frequency acoustics are...the Eikonal equation derived from the high frequency approximation to the wave equation, ucuH ∇±=∇ )(),( xx , with the nonnegative function c(x...For simplicity, we only consider the case ucuH ∇+=∇ )(),( xx . Two difficulties must be addressed when solving the Eikonal equation in a fixed

  3. Statistics of the thyroid pathology operated in the ORL-CCC service of the Hospital Rafael Angel Calderon Guardia, between 2008-2012

    International Nuclear Information System (INIS)

    Ramos Castro, Paula

    2013-01-01

    The statistics of the Servicio de Otorrinolaringologia y Cirugia de Cabeza y Cuello de Hospital Rafael Angel Calderon Guardia were described, in terms of thyroid surgery; in the period from January 1, 2008 to December 31, 2012, compiling 200 cases of operated patients. Due to the increase in the diagnosis of these diseases in the Costa Rican hospital environment and the lack of an instrument to evaluate the therapeutic action, the need to perform an evaluation of the surgical management given to thyroid pathology is born. Through a table of data complications and the systematic review of the records of the population, the presentation of the results obtained was made using the inclusion criteria such as: patients older than 12 years, diagnosis of benign or malignant thyroid pathology with need of surgical resolution, presence of BAAF reported in medical record, case report of patient in interdisciplinary thyroid session, with surgery or surgeries performed in the period between January 2008 and December 2012, with a written report of surgery and biopsy defined with medical record. The exclusion criteria were: patients without reports of FNAB, operative sheet and/or defined biopsy with medical record, patients whose medical record will not be located in the hospital center to collect the information. (author) [es

  4. Predictors (0-10 months) of psychopathology at age 1 1/2 years - a general population study in The Copenhagen Child Cohort CCC 2000

    DEFF Research Database (Denmark)

    Skovgaard, Anne Mette; Olsen, Else Marie; Christiansen, E.

    2008-01-01

    /2-5), Infant Toddler Symptom Check List (ITSCL), Checklist for Autism in Toddlers (CHAT), Bayley Scales of Infant Development (BSID II), Mannheim Eltern Interview (MEI), Parent Child Early Relational Assessment (PC ERA) and Parent Infant Relationship Global Assessment Scale (PIR-GAS), and disordered children...... were diagnosed according to the International Classification of Diseases (ICD-10) and Diagnostic Classification Zero to Three (DC: 0-3). Results: Deviant language development in the first 10 months of life predicted the child having any disorder at 11/2 years, OR 3.3 (1.4-8.0). Neuro-developmental...... disorders were predicted by deviant neuro-cognitive functioning, OR 6.8 (2.2-21.4), deviant language development, OR 5.9 (1.9-18.7) and impaired social interaction and communication, OR 3.8 (1.3-11.4). Unwanted pregnancy and parents' negative expectations of the child recorded in the first months...

  5. The influence of pressure on diffusion leading to intermetallic compounds

    International Nuclear Information System (INIS)

    Adda, Y.; Beyeler, M.; Kirianenko, A.; Pernot, B.

    1961-01-01

    Some investigators A.D. LE CLAIRE, J.L. ZAMBROW, L. CASTLEMAN, have shown that the application of uniaxial pressure parallel to the direction of diffusion may notably modify the kinetics of growth of the intermediate phases which can be formed in this direction. The interpretation of this phenomenon being obscure, an attempt is made to explain it by detailed analysis of the experimental facts. The microscopic studies of the kinetics of growth of the zones formed shows particularly in the couples Uranium-Copper and Uranium-Nickel that it is influenced in a similar manner by a uniaxial pressure and a hydrostatic one. On the other hand the rate of growth of these zones increases as a function of the applied pressure in the systems Uranium-Copper, Uranium-Nickel and Uranium-Aluminium (this effect being particularly marked in Uranium-Aluminium). To determine with precision the limits of the range of stability of the intermetallic compounds, the curves of concentration penetration characteristics of the diffusion have been established by means of the CASTAING electronic microanalyser. The examination of the results indicates that when diffusion takes place without external pressure (couples U-Cu and U-Ni) or with a pressure less than 300 kg/cm 2 (couple U-Al) the concentration varies notably in the compounds obtained, which theoretically are stoichiometric. Thus, when crossing the zone of diffusion of one base metal to another one notes a continual passage of: UCu 4.70 to UCu 5.25 in the couple U-Cu; UNi 4.75 to UNi 5.25 in the couple U-Ni; UAl 2.2 to UAl 3.3 in the couple U-Al. If an uniaxial or hydrostatic pressure above 500 kg/cm 2 is applied to the couples U-Cu and U-Ni, or above 1000 kg/cm 2 for the couple U-Al, the composition is then constant in the zones formed. It corresponds to: UCu 5 in the couple U-Cu; UNi 5 in the couple U-Ni; UAl 3 in the couple U-Al. These results are confirmed by an X-ray diffraction study, mainly in the U-Cu system. Experiments in

  6. 7 CFR 1427.1088 - Contract fees.

    Science.gov (United States)

    2010-01-01

    ... storage and handling of CCC-owned cotton or cotton pledged to CCC as loan collateral must pay an annual... storage and handling of CCC-owned cotton or cotton pledged to CCC as loan collateral but who desires such... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COTTON Standards for Approval of Warehouses for...

  7. 7 CFR 1421.109 - Personal liability of the producer.

    Science.gov (United States)

    2010-01-01

    ...) Remove or dispose of a quantity of commodity that is collateral for a CCC farm-stored loan without prior... CCC. CCC will demand delivery of any remaining loan collateral if not repaid within the 30 calendar... the loan collateral without the approval of CCC. (m) A producer shall be personally liable for damages...

  8. Retención y Penetración en Estacones de Eucalyptus Saligna. Sometidos a Tratamiento con CuSO4 y Sal CCC, en Baño Caliente y frio y Vacio-Presión

    Directory of Open Access Journals (Sweden)

    Escobar C. Oscar

    1987-09-01

    Full Text Available Este trabajo describe y da los resultados obtenidos con el pretratamiento de estacones de Eucalyptus saligna a tres soluciones de CUS04 y su posterior tratamiento con sales CCA (OSMOSE K-33. El sulfato de cobre se aplicó por el método de baño caliente y frío, seguido por el proceso de difusión durante una semana; para los anteriores tratamientos se usó madera verde o parcialmente seca al aire; las sales CCA se aplicaron a madera seca por el método de vacío-presión. Una de las razones para llevar a cabo este refuerzo de las sales CCA, es haber encontrado postes de eucalipto severamente atacados por hongos, en especial con pudrición blanda. Los estacones fueron tratados inicialmente con soluciones de sulfato de cobre a 1 %, 2% y 3% de concentración; luego los estacones fueron tratados con una solución de sal CCA al 2.5% de concentración por vacío-presión. Se usaron 40 estacones distribuídos en 4 grupos de 10: tres (3 grupos fueron usados para el tratamiento con las soluciones de CUS04 y solución de CCA; el grupo restante fue tratado con la sal CCA únicamente, el cual fue usado como grupo testigo para fines de comparación en los ensayos de campo (cementerios.

  9. Can a general health surveillance between birth and 10 months identify children with mental disorder at 1(1/2) year? A case-control study nested in cohort CCC 2000

    DEFF Research Database (Denmark)

    Skovgaard, Anne Mette; Houmann, Tine; Christiansen, Eva Storgaard

    2008-01-01

    Mental health surveillance in infancy was studied in an existing child health surveillance programme with child psychiatric disorder at 1(1/2) year as the outcome.......Mental health surveillance in infancy was studied in an existing child health surveillance programme with child psychiatric disorder at 1(1/2) year as the outcome....

  10. Walter Reed Army Medical Center, Washington, DC Annual Progress Report FY-89. Volume 2. Part 1

    Science.gov (United States)

    1990-01-02

    stew , 15 lamb liver cubes, and 250 cc of water, each labeled with 50 uCu of 99m Technesium sulfur-colloid. The patients lay on the left and right side...meal of commercial beef stew and a liquid radionuclide are ingested. Patients are monitored for 20 minutes in the recumbent position by Nuclear Medicine

  11. The influence of pressure on diffusion leading to intermetallic compounds; Influence de la pression sur les diffusions donnant naissance a des composes intermetalliques

    Energy Technology Data Exchange (ETDEWEB)

    Adda, Y; Beyeler, M; Kirianenko, A; Pernot, B [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1961-07-01

    Some investigators A.D. LE CLAIRE, J.L. ZAMBROW, L. CASTLEMAN, have shown that the application of uniaxial pressure parallel to the direction of diffusion may notably modify the kinetics of growth of the intermediate phases which can be formed in this direction. The interpretation of this phenomenon being obscure, an attempt is made to explain it by detailed analysis of the experimental facts. The microscopic studies of the kinetics of growth of the zones formed shows particularly in the couples Uranium-Copper and Uranium-Nickel that it is influenced in a similar manner by a uniaxial pressure and a hydrostatic one. On the other hand the rate of growth of these zones increases as a function of the applied pressure in the systems Uranium-Copper, Uranium-Nickel and Uranium-Aluminium (this effect being particularly marked in Uranium-Aluminium). To determine with precision the limits of the range of stability of the intermetallic compounds, the curves of concentration penetration characteristics of the diffusion have been established by means of the CASTAING electronic microanalyser. The examination of the results indicates that when diffusion takes place without external pressure (couples U-Cu and U-Ni) or with a pressure less than 300 kg/cm{sup 2} (couple U-Al) the concentration varies notably in the compounds obtained, which theoretically are stoichiometric. Thus, when crossing the zone of diffusion of one base metal to another one notes a continual passage of: UCu{sub 4.70} to UCu{sub 5.25} in the couple U-Cu; UNi{sub 4.75} to UNi{sub 5.25} in the couple U-Ni; UAl{sub 2.2} to UAl{sub 3.3} in the couple U-Al. If an uniaxial or hydrostatic pressure above 500 kg/cm{sup 2} is applied to the couples U-Cu and U-Ni, or above 1000 kg/cm{sup 2} for the couple U-Al, the composition is then constant in the zones formed. It corresponds to: UCu{sub 5} in the couple U-Cu; UNi{sub 5} in the couple U-Ni; UAl{sub 3} in the couple U-Al. These results are confirmed by an X

  12. Effect of Curved Radial Vane Cavity Arrangements on Predicted Inter-Turbine Burner (ITB) Performance

    Science.gov (United States)

    2007-06-01

    in the cavity, and the vaporization, mixing of fuel and air, and combustion amount of unburned fuel shedding out of the becomes very challenging ...the payoff UUC/ITB concepts becomes critical. UCC/ITB was provided to define the geometry and served flamy hco de wih a ane as the staring point for...for the development and equations for mass, momentum, energy, chemical species, modification of the computer- aided design models, as and turbulence were

  13. Low frequency of defective mismatch repair in a population-based series of upper urothelial carcinoma

    International Nuclear Information System (INIS)

    Ericson, Kajsa M; Isinger, Anna P; Isfoss, Björn L; Nilbert, Mef C

    2005-01-01

    Upper urothelial cancer (UUC), i.e. transitional cell carcinomas of the renal pelvis and the ureter, occur at an increased frequency in patients with hereditary nonpolyposis colorectal cancer (HNPCC). Defective mismatch repair (MMR) specifically characterizes HNPCC-associated tumors, but also occurs in subsets of some sporadic tumors, e.g. in gastrointestinal cancer and endometrial cancer. We assessed the contribution of defective MMR to the development of UUC in a population-based series from the southern Swedish Cancer Registry, through microsatellite instability (MSI) analysis and immunohistochemical evaluation of expression of the MMR proteins MLH1, PMS2, MSH2, and MSH6. A MSI-high phenotype was identified in 9/216 (4%) successfully analyzed patients and a MSI-low phenotype in 5/216 (2%). Loss of MMR protein immunostaining was found in 11/216 (5%) tumors, and affected most commonly MSH2 and MSH6. This population-based series indicates that somatic MMR inactivation is a minor pathway in the development of UUC, but tumors that display defective MMR are, based on the immunohistochemical expression pattern, likely to be associated with HNPCC

  14. Low frequency of defective mismatch repair in a population-based series of upper urothelial carcinoma

    Directory of Open Access Journals (Sweden)

    Isfoss Björn L

    2005-03-01

    Full Text Available Abstract Background Upper urothelial cancer (UUC, i.e. transitional cell carcinomas of the renal pelvis and the ureter, occur at an increased frequency in patients with hereditary nonpolyposis colorectal cancer (HNPCC. Defective mismatch repair (MMR specifically characterizes HNPCC-associated tumors, but also occurs in subsets of some sporadic tumors, e.g. in gastrointestinal cancer and endometrial cancer. Methods We assessed the contribution of defective MMR to the development of UUC in a population-based series from the southern Swedish Cancer Registry, through microsatellite instability (MSI analysis and immunohistochemical evaluation of expression of the MMR proteins MLH1, PMS2, MSH2, and MSH6. Results A MSI-high phenotype was identified in 9/216 (4% successfully analyzed patients and a MSI-low phenotype in 5/216 (2%. Loss of MMR protein immunostaining was found in 11/216 (5% tumors, and affected most commonly MSH2 and MSH6. Conclusion This population-based series indicates that somatic MMR inactivation is a minor pathway in the development of UUC, but tumors that display defective MMR are, based on the immunohistochemical expression pattern, likely to be associated with HNPCC.

  15. Low frequency of defective mismatch repair in a population-based series of upper urothelial carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Ericson, Kajsa M; Isinger, Anna P [Departments of Oncology, University Hospital, Lund (Sweden); Isfoss, Björn L [Departments of Pathology, University Hospital, Lund (Sweden); Nilbert, Mef C [Departments of Oncology, University Hospital, Lund (Sweden)

    2005-01-01

    Upper urothelial cancer (UUC), i.e. transitional cell carcinomas of the renal pelvis and the ureter, occur at an increased frequency in patients with hereditary nonpolyposis colorectal cancer (HNPCC). Defective mismatch repair (MMR) specifically characterizes HNPCC-associated tumors, but also occurs in subsets of some sporadic tumors, e.g. in gastrointestinal cancer and endometrial cancer. We assessed the contribution of defective MMR to the development of UUC in a population-based series from the southern Swedish Cancer Registry, through microsatellite instability (MSI) analysis and immunohistochemical evaluation of expression of the MMR proteins MLH1, PMS2, MSH2, and MSH6. A MSI-high phenotype was identified in 9/216 (4%) successfully analyzed patients and a MSI-low phenotype in 5/216 (2%). Loss of MMR protein immunostaining was found in 11/216 (5%) tumors, and affected most commonly MSH2 and MSH6. This population-based series indicates that somatic MMR inactivation is a minor pathway in the development of UUC, but tumors that display defective MMR are, based on the immunohistochemical expression pattern, likely to be associated with HNPCC.

  16. The prevalence of mental health problems in children 1(1/2) years of age - the Copenhagen Child Cohort 2000

    DEFF Research Database (Denmark)

    Skovgaard, Anne Mette; Houmann, Tine; Christiansen, Eva Storgaard

    2007-01-01

    The Copenhagen Child Cohort, CCC 2000, was established to investigate developmental psychopathology prospectively from birth in a general population.......The Copenhagen Child Cohort, CCC 2000, was established to investigate developmental psychopathology prospectively from birth in a general population....

  17. 7 CFR 1427.3 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... they conflict with definitions in this section. Adjusted spot price means the spot price adjusted to... to CCC; and (5) Providing loan, loan deficiency payment, and accounting data to CCC for statistical...

  18. Clear cell carcinomas of the ovary have poorer outcomes compared with serous carcinomas: Results from a single-center Taiwanese study

    Directory of Open Access Journals (Sweden)

    Fei-Chun Ku

    2018-02-01

    Conclusion: The clinical outcomes of CCC are generally poorer than SC. Complete cytoreduction to no gross residual disease should be ideally achieved in CCC patients. A greater understanding of the molecular pathogenesis of CCC may lead to tailored therapies, ultimately optimizing outcomes.

  19. Duck hepatitis B virus covalently closed circular DNA appears to survive hepatocyte mitosis in the growing liver

    International Nuclear Information System (INIS)

    Reaiche-Miller, Georget Y.; Thorpe, Michael; Low, Huey Chi; Qiao, Qiao; Scougall, Catherine A.; Mason, William S.; Litwin, Samuel; Jilbert, Allison R.

    2013-01-01

    Nucleos(t)ide analogues that inhibit hepatitis B virus (HBV) DNA replication are typically used as monotherapy for chronically infected patients. Treatment with a nucleos(t)ide analogue eliminates most HBV DNA replication intermediates and produces a gradual decline in levels of covalently closed circular DNA (cccDNA), the template for viral RNA synthesis. It remains uncertain if levels of cccDNA decline primarily through hepatocyte death, or if loss also occurs during hepatocyte mitosis. To determine if cccDNA survives mitosis, growing ducklings infected with duck hepatitis B virus (DHBV) were treated with the nucleoside analogue, Entecavir. Viremia was suppressed at least 10 5 -fold, during a period when average liver mass increased 23-fold. Analysis of the data suggested that if cccDNA synthesis was completely inhibited, at least 49% of cccDNA survived hepatocyte mitosis. However, there was a large duck-to-duck variation in cccDNA levels, suggesting that low level cccDNA synthesis may contribute to this apparent survival through mitosis. - Highlights: • The hepatitis B virus nuclear template is covalently closed circular DNA (cccDNA). • cccDNA was studied during liver growth in duck hepatitis B virus infected ducks. • Virus DNA replication and new cccDNA synthesis were inhibited with Entecavir. • At least 49% of cccDNA appeared to survive hepatocyte mitosis. • Low level virus DNA synthesis may contribute to survival of cccDNA through mitosis

  20. Duck hepatitis B virus covalently closed circular DNA appears to survive hepatocyte mitosis in the growing liver

    Energy Technology Data Exchange (ETDEWEB)

    Reaiche-Miller, Georget Y.; Thorpe, Michael; Low, Huey Chi; Qiao, Qiao; Scougall, Catherine A. [School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005 (Australia); Mason, William S.; Litwin, Samuel [Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111 (United States); Jilbert, Allison R., E-mail: allison.jilbert@adelaide.edu.au [School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005 (Australia)

    2013-11-15

    Nucleos(t)ide analogues that inhibit hepatitis B virus (HBV) DNA replication are typically used as monotherapy for chronically infected patients. Treatment with a nucleos(t)ide analogue eliminates most HBV DNA replication intermediates and produces a gradual decline in levels of covalently closed circular DNA (cccDNA), the template for viral RNA synthesis. It remains uncertain if levels of cccDNA decline primarily through hepatocyte death, or if loss also occurs during hepatocyte mitosis. To determine if cccDNA survives mitosis, growing ducklings infected with duck hepatitis B virus (DHBV) were treated with the nucleoside analogue, Entecavir. Viremia was suppressed at least 10{sup 5}-fold, during a period when average liver mass increased 23-fold. Analysis of the data suggested that if cccDNA synthesis was completely inhibited, at least 49% of cccDNA survived hepatocyte mitosis. However, there was a large duck-to-duck variation in cccDNA levels, suggesting that low level cccDNA synthesis may contribute to this apparent survival through mitosis. - Highlights: • The hepatitis B virus nuclear template is covalently closed circular DNA (cccDNA). • cccDNA was studied during liver growth in duck hepatitis B virus infected ducks. • Virus DNA replication and new cccDNA synthesis were inhibited with Entecavir. • At least 49% of cccDNA appeared to survive hepatocyte mitosis. • Low level virus DNA synthesis may contribute to survival of cccDNA through mitosis.

  1. Conseil de la Cooperation Culturelle et Fonds Culturel. Rapport Annuel 1972. (Council for Cultural Co-operation and Cultural Fund. Annual Report 1972.)

    Science.gov (United States)

    Council for Cultural Cooperation, Strasbourg (France).

    This document is a report on the activities of the Council for Cultural Co-Operation (CCC) and Cultural Fund for 1972. The CCC is briefly defined as being designed to reinforce educational and cultural cooperation among the 21 countries of the CCC, especially in matters of research, information, and documentation. The document is composed of…

  2. 7 CFR 1435.103 - Availability, disbursement, and maturity of loans.

    Science.gov (United States)

    2010-01-01

    ... information as prescribed by CCC of the commodity to be pledged as collateral; (4) Pay CCC a loan service fee... on sugar or in-process sugar pledged as loan collateral, obtain waivers that fully protect CCC's... produced and are otherwise established as being eligible to be pledged as loan collateral. (c)(1) A...

  3. 7 CFR 1435.503 - In-kind payments.

    Science.gov (United States)

    2010-01-01

    ... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS SUGAR PROGRAM Processor Sugar Payment-In-Kind... CCC-owned inventory is dependent upon the storage location of the sugar and the type of sugar (raw or... dividing: (1) The total of the processor's bid amount that CCC accepts, by (2) The value of CCC's inventory...

  4. Censorship during the Depression: The Banning of "You and Machines."

    Science.gov (United States)

    Barry, Arlene L.

    2001-01-01

    Provides background information on the Civilian Conservation Corps (CCC) focusing on the educational programs for the CCC. Presents a lesson on the censorship of the booklet "You and Machines" from the CCC programs. Includes excerpts from "You and Machines," copies of newspaper articles about the booklet, and a student handout.…

  5. 7 CFR 1400.502 - Compliance and enforcement.

    Science.gov (United States)

    2010-01-01

    ... CCC from a certified public accountant or attorney that the average adjusted gross income of the... supporting financial data as requested by CCC. Supporting financial data may include State income tax returns... the person's or legal entity's income; or (4) Authorization for CCC to obtain tax data from the...

  6. 7 CFR 1493.80 - Evidence of export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Evidence of export. 1493.80 Section 1493.80... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Export Credit Guarantee Program (GSM-102) and CCC Intermediate Export Credit Guarantee Program (GSM-103...

  7. Eskişehir koşullarında yetiştirilen Reyhan (Ocimum basilicum L.) bitkisinin bazı bitkisel özelliklerin ve diurnal varyabilitesinin belirlenmesi

    OpenAIRE

    Kulan, Engin Gökhan

    2013-01-01

    Bu çalışma Eskişehir Osmangazi Üniversitesi Ziraat Fakültesi Tarla Bitkileri Bölümü deneme alanında 2010 yılında yürütülmüştür. Denemede Eskişehir ekolojik koşullarında yetiştirilen reyhan (Ocimum basilicum L.) bitkisinin verim ve verim özellikleri ile farklı biçim saatlerinin reyhanın uçucu yağı ve uçucu yağ bileşimi üzerine olan etkileri incelenmiştir. Tesadüf bloklarında bölünmüş parseller deneme desenine göre 3 tekerrürlü olarak kurulan denemede reyhan bitkileri çiçeklen...

  8. Fitoterapide karminatif olarak kullanılan Apiaceae Meyvaları (Foeniculum vulgare, Pimpinella anisum)

    OpenAIRE

    ORTANCIL, Mahmut

    2006-01-01

    Bu çalışmada halk arasında karminatif olarak kullanılan Apiacea bitkileri Foeniculum vulgareve Pimpinella anisum'un kimyasal özellikleri ve biyolojik etkileri literatür verilerine dayanılarak incelenmiştir.Pimpinella anisum uçucu yağının büyük kısmını anetol oluşturmaktadır. Uçucu yağda ayrıcaöstragol, kumarin yapısında bileşikler (bergapten, umbelliferon ve skopoletol), lipitler(petroselinik asit, palmitik asit, linoleik asit) ve flavonoitler de bulunmaktadır.Pimpinella ...

  9. Neoliberalismo en la Universidad Metropolitana de Manchester... y una alternativa

    Directory of Open Access Journals (Sweden)

    Third Person

    2012-12-01

    Full Text Available Una campaña contra la persecución a miembros del sindicato de la Metropolitan University of Manchester (MMU ha logrado una victoria importante. La campaña ha sido liderada por el University and College Union (UCU y un grupo de estudiantes de postgrado y profesores visitantes. Todos ellos aunaron esfuerzos en acto de solidaridad con Ian Parker, catedrático de psicología crítica y representante sindical de la  UCU, tras su suspensión provisional del Departamento de Psicología desde principios del mes de octubre. La campaña también ha permitido reforzar el apoyo a Christine Vié, Copresidenta de la sede de UCU en la MMU, también cesada tras la suspensión de las asignaturas de postgrados que impartía. Los motivos de la suspensión de Ian Parker, la campaña a favor de su caso (y el de otros colegas en situación parecida y el posterior intento de la MMU de desdecirse para intentar salir bien parada, son todos ellos representativos de una política de gestión neoliberal universitaria así como de acciones posibles para contrarrestarla.

  10. Assessment of training needs and preferences for geographic information systems (GIS) mapping in state comprehensive cancer-control programs.

    Science.gov (United States)

    Hopfer, Suellen; Chadwick, Amy E; Parrott, Roxanne L; Ghetian, Christie B; Lengerich, Eugene J

    2009-10-01

    Geographic information systems (GIS) mapping technologies have potential to advance public health promotion by mapping regional differences in attributes (e.g., disease burden, environmental exposures, access to health care services) to suggest priorities for public health interventions. Training in GIS for comprehensive cancer control (CCC) has been overlooked. State CCC programs' GIS training needs were assessed by interviewing 49 state CCC directors. A majority perceived a need for GIS training, slightly more than half of state CCC programs had access to geocoded data, and the majority of programs did not require continuing education credits of their staff. CCC directors perceived judging maps and realizing their limitations as important skills and identified epidemiologists, CCC staff, public health officials, policy makers, and cancer coalition members as training audiences. They preferred in-class training sessions that last a few hours to a day. Lessons learned are shared to develop training programs with translatable GIS skills for CCC.

  11. Bitki Sıklığının İki Farklı Kişniş (Coriandrum sativum L. Çeşidinde Verim ve Verim Unsurları Üzerine Etkisinin Belirlenmesi

    Directory of Open Access Journals (Sweden)

    Duran Katar

    2016-05-01

    Full Text Available Çalışma; çeşitlerin ve bitki sıklığının kişniş (Coriandrum sativum L. bitkisinin verim, verim unsurları ve uçucu yağ verimi üzerine etkisini belirlemek amacıyla; 2012 ve 2013 yıllarında Eskişehir Osmangazi Üniversitesi Ziraat Fakültesi Tarla Bitkileri Bölümü deneme tarlasında, Tesadüf Bloklarında Faktöriyel Deneme Desenine göre 8 uygulama ve 3 tekerrürlü olarak yürütülmüştür. Faktörler; çeşitler (Arslan ve Gürbüz ve 4 farklı bitki sıklığı (20, 30, 40 ve 50 bitki m-2’dır. Çalışma sonuçları; Arslan çeşidine kıyasla Gürbüz çeşidinden daha yüksek bitki boyu, uçucu yağ oranı ve uçucu yağ verimi elde edildiğini göstermiştir. Ayrıca bitki sıklığı değerlendirmeye alınan özelliklerin tümü üzerinde önemli etkiler göstermiştir. Maksimum bitki boyu, uçucu yağ oranı ve uçucu yağ verimi 50 bitki m-2; en yüksek bitki başına şemsiye sayısı, 1000 tohum ağırlığı ve tohum verimi sırasıyla 20, 30 ve 40 bitki m-2 bitki sıklıklarından elde edilmiştir.

  12. 22nd and 23rd June 2009-Mexico,Mtro. Enrique Agüera Ibanez,Rector of Benemerita Universidad Autonoma de Puebla-visiting CMS and ALICE underground areas,AD,CCC,Grid with Adviser for Latin America J. Salicio

    CERN Multimedia

    Maximilien Brice

    2009-01-01

    Tirage 1-5:ALICE underground area with ALICE Collaboration Spokesperson J. Schukraft Tirage 6-10: ALICE exhibition Tirage 16-25:signing the Guest book with Director for Research and Scientific Computing S. Bertolucci and Coordinator for External Relations F. Pauss

  13. Pretreatment Neutrophil-Lymphocyte Ratio as a Predictor in Bladder Cancer and Metastatic or Unresectable Urothelial Carcinoma Patients: a Pooled Analysis of Comparative Studies.

    Science.gov (United States)

    Wu, Shuiqing; Zhao, Xiaokun; Wang, Yinhuai; Zhong, Zhaohui; Zhang, Lei; Cao, Jian; Ai, Kai; Xu, Ran

    2018-01-01

    Emerging studies have shown that the neutrophil-lymphocyte ratio (NLR) is a potential predictor in various tumors. Our study was conducted to assess the prognostic value of the pretreatment NLR in bladder cancer and metastatic or unresectable urothelial carcinoma (mUC or uUC) patients up to July 2017. The correlation between the pretreatment NLR and pathological characteristics was also evaluated in bladder cancer patients. The hazard ratio (HR) and odds ratio (OR) with the 95% confidence interval (CI) were extracted or calculated from the included studies for further pooled analysis. A total of 21 studies were included in a pooled analysis. The pooled results indicated that a high pretreatment NLR was associated with reduced overall survival (OS) (HR=1.27, 95% CI=1.12-1.43), relapse-free survival (RFS) (HR=1.41, 95% CI=1.23-1.60), progression-free survival (PFS) (HR=1.75, 95% CI=1.36-2.15), disease-specific survival (DSS) and cancer-specific survival (CSS) (HR=1.27, 95% CI=1.19-1.35) in the bladder cancer patients. Additionally, an elevated pretreatment NLR suggested a worse OS rate in the mUC or uUC patients (HR=1.63, 95% CI=1.34-1.91). The pooled ORs and 95% CIs showed that a high pretreatment NLR could be a risk indicator for certain pathological features, such as lymphovascular invasion, a positive margin status and advanced tumor stage. our results showed that a high pretreatment NLR predicted poor prognosis in bladder cancer, mUC and uUC patients. © 2018 The Author(s). Published by S. Karger AG, Basel.

  14. Simultaneous Bilateral Ureteral Calculi: A New Paradigm for Management.

    Science.gov (United States)

    Scotland, Kymora B; Hubosky, Scott G; Tanimoto, Ryuta; Cooper, Robert; Healy, Kelly A; Bagley, Demetrius H

    2018-05-21

    To define the need for emergent intervention between patients with simultaneous bilateral ureteral calculi (SBUC) compared to unilateral ureteral calculi (UUC). Patients with SBUC represent a potential urological emergency due to possible anuria or electrolyte imbalance. While conventional practice mandates immediate intervention in these patients, little data exist to define the rate of these events. Records of all patients with ureteral stones treated ureteroscopically over an 11-year period were reviewed to identify those with SBUC. Patient presenting characteristics, time from diagnosis to intervention, and postoperative outcomes were noted. To determine the need for emergent intervention, we compared metabolic and infectious parameters between SBUC patients and age- and sex-matched patients with UUC. A total of 3800 patients presented with ureteral calculi including 42 (1.1%) with SBUC. Two-thirds of patients with SBUC had an established diagnosis of nephrolithiasis. Among the 42 patients with SBUC, 11 (26.2%) were considered emergent due to metabolic (5 of 11, 45.5%), infectious (1 of 11, 9.1%), or both metabolic and infectious indications (5 of 11, 45.5%). No patients required acute dialysis before surgical intervention. Compared to patients with UUC, those with SBUC were significantly more likely to require emergent management (P = .03, odds ratio 2.3). Univariate and multivariate analyses showed this to be due to anuria (P = .001) and acidosis (P = .003). SBUC is an uncommon condition and, in this series, only the minority of patients presented emergently. Therefore, patients with SBUC can often be managed electively if counseled on clinical signs warranting emergent medical attention. Appropriately selected patients have excellent outcomes following single stage bilateral ureteroscopy. Copyright © 2018. Published by Elsevier Inc.

  15. Evidence for the horizontal transfer of an integrase gene from a fusellovirus to a pRN-like plasmid within a single strain of Sulfolobus and the implications for plasmid survival

    DEFF Research Database (Denmark)

    Peng, Xu

    2008-01-01

    of the integrase gene occurs in the viral attachment site (attP), which corresponds to the anticodon region of the targeted tRNA gene in the host chromosome. This point mutation confers on pXZ1 the ability to integrate into the tRNA(Glu)[CUC] gene, which differs from the integration site of SSV4, t......RNA(Glu)[UUC]. SSV4 and pXZ1 were also shown experimentally to integrate into separate sites on the host chromosome. This is believed to be the first report of a pRN plasmid sharing its natural host with a fusellovirus and carrying a highly similar integrase gene....

  16. A Study to Determine the Feasibility of Implementing Same-Day Surgery at Brooke Army Medical Center

    Science.gov (United States)

    1989-02-01

    trend was well received by hospitals because of the shortage of health facilities and sparse hospital construction during the Depression and World Same...4.4c; Ř ... UM zCCWIAOOO W’ MAMA 0 Cd CdLf% w a z Cd*@44M~ _ __ ’ MOM. - 00000 I~4lBA0.4g%ly0 0 aC." g~ e .... a . u VIC .40 9 Cd Cd WW 00" TW1 uuc O...OF STEROID R 9924 INJECTION OF OTHER HORMONE 9925 INJECT/INFUSE CANCER CHEMOTHERAPEUTIC SUBSTANCE (REV 1/88) 9926 INJECTION OF TRANQUILIZER 9927

  17. Transcription of hepatitis B virus covalently closed circular DNA is regulated by CpG methylation during chronic infection.

    Directory of Open Access Journals (Sweden)

    Yongmei Zhang

    Full Text Available The persistence of hepatitis B virus (HBV infection is maintained by the nuclear viral covalently closed circular DNA (cccDNA, which serves as transcription template for viral mRNAs. Previous studies suggested that cccDNA contains methylation-prone CpG islands, and that the minichromosome structure of cccDNA is epigenetically regulated by DNA methylation. However, the regulatory effect of each CpG island methylation on cccDNA activity remains elusive. In the present study, we analyzed the distribution of CpG methylation within cccDNA in patient samples and investigated the impact of CpG island methylation on cccDNA-driven virus replication. Our study revealed the following observations: 1 Bisulfite sequencing of cccDNA from chronic hepatitis B patients indicated that CpG island I was seldom methylated, 2 CpG island II methylation was correlated to the low level of serum HBV DNA in patients, and in vitro methylation studies confirmed that CpG island II methylation markedly reduced cccDNA transcription and subsequent viral core DNA replication, 3 CpG island III methylation was associated with low serum HBsAg titers, and 4 Furthermore, we found that HBV genotype, HBeAg positivity, and patient age and liver fibrosis stage were also relevant to cccDNA CpG methylation status. Therefore, we clearly demonstrated that the status of cccDNA methylation is connected to the biological behavior of HBV. Taken together, our study provides a complete profile of CpG island methylation within HBV cccDNA and new insights for the function of CpG methylation in regulating HBV cccDNA transcription.

  18. Comparison of Clinical Characteristic and Prognosis between Ovarian Clear Cell Carcinoma and Serous Carcinoma: A 10-Year Cohort Study of Chinese Patients.

    Science.gov (United States)

    Ye, Shuang; Yang, Jiaxin; You, Yan; Cao, Dongyan; Huang, Huifang; Wu, Ming; Chen, Jie; Lang, Jinghe; Shen, Keng

    2015-01-01

    To compare the clinicopathologic features and prognosis of Chinese patients with ovarian clear cell carcinoma (CCC) and serous carcinoma (SC). A retrospective cohort study was designed to investigate the clinicopathologic characteristic and prognosis of patients with CCC and SC who were diagnosed and treated in in a tertiary referral center (Peking Union Medical College Hospital) between 1999 and 2009. The Kaplan-Meier method and Cox regression were employed in the survival analysis. A total of 504 cases were included in the study, comprising 197 cases of CCC and 307 cases of SC. The mean age of the patients with SC was greater than of CCC patients (3.6±0.94, PPatients with CCC were more likely to be early-stage and optimally debulked (Ppatients with CCC had normal values, and the level was significantly lower than in patients with SC (Ppatients had platinum-resistant tumors compared with platinum-sensitive disease (45.7% in CCC vs. 61.0% in SC [P=0.008]). The 5-year survival rate was 51.2% in the CCC group vs. 49.8% in the SC group (P=0.428). Patients with advanced CCC had a statistically significant poorer overall survival (OS) compared with their SC counterparts (38.0 vs. 52.0 months; hazard ratio 1.584, 95% confidence interval [CI] 1.167-2.150, P=0.003). However, the advantage of improved progression-free survival (PFS) existed across all stages. Women with ovarian CCC presented at a younger age and early stage. Patients with ovarian CCC also had improved PFS, but they had similar OS compared to patients with SC. However, patients with advanced CCC had decreased survival.

  19. Detection of HBV Covalently Closed Circular DNA

    Directory of Open Access Journals (Sweden)

    Xiaoling Li

    2017-06-01

    Full Text Available Chronic hepatitis B virus (HBV infection affects approximately 240 million people worldwide and remains a serious public health concern because its complete cure is impossible with current treatments. Covalently closed circular DNA (cccDNA in the nucleus of infected cells cannot be eliminated by present therapeutics and may result in persistence and relapse. Drug development targeting cccDNA formation and maintenance is hindered by the lack of efficient cccDNA models and reliable cccDNA detection methods. Southern blotting is regarded as the gold standard for quantitative cccDNA detection, but it is complicated and not suitable for high-throughput drug screening, so more sensitive and simple methods, including polymerase chain reaction (PCR-based methods, Invader assays, in situ hybridization and surrogates, have been developed for cccDNA detection. However, most methods are not reliable enough, and there are no unified standards for these approaches. This review will summarize available methods for cccDNA detection. It is hoped that more robust methods for cccDNA monitoring will be developed and that standard operation procedures for routine cccDNA detection in scientific research and clinical monitoring will be established.

  20. Technical note: Evaluation of the uncertainties in (choline+creatine)/citrate ratios measured by proton MR spectroscopic imaging in patients suspicious for prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Zbyn, S.; Krssak, M.; Memarsadeghi, M.; Gholami, B.; Haitel, A.; Weber, M.; Helbich, T.H.; Trattnig, S.; Moser, E.; Gruber, S.

    2014-07-15

    The presented evaluation of the relative uncertainty (δ'CCC) of the (choline + creatine)/citrate (CC/C) ratios can provide objective information about the quality and diagnostic value of prostate MR spectroscopic imaging data. This information can be combined with the numeric values of CC/C ratios and provides metabolic-quality maps enabling accurate cancer detection and user-independent data evaluation. In addition, the prostate areas suffering most from the low precision of CC/C ratios (e. g., prostate base) were identified.

  1. Using cover, copy, and compare spelling with and without timing for elementary students with behavior disorders

    Directory of Open Access Journals (Sweden)

    Danette Darrow

    2012-04-01

    Full Text Available The purpose of this study was to determine the effectiveness of cover, copy, and compare (CCC procedures on spelling performance with two students. The participants were two elementary students enrolled in a self-contained behavior intervention classroom. A multiple baseline design across participants was employed to evaluate the effects of CCC on time to completion and words spelled correctly. Improvements in all measures were found when CCC was in effect. The participants enjoyed the procedures and each improved their spelling over baseline performance. The applicability of CCC across academic contexts and for students with behavior disorders was discussed.

  2. Cryogenic Current Comparator for Storage Rings and Accelerators

    OpenAIRE

    Geithner, Rene; Fernandes, Miguel; Kurian, Febin; Neubert, Ralf; Reeg, Hansjörg; Schwickert, Marcus; Seidel, Paul; Sieber, Thomas; Stöhlker, Thomas

    2016-01-01

    A Cryogenic Current Comparator (CCC) was developed for a non-destructive, highly sensitive monitoring of nA beams at the planned FAIR accelerator facility at GSI. The sensor part of the CCC was optimized for lowest possible noise-limited current resolution in combination with a high system bandwidth of about 200 kHz. It is foreseen to install the CCC inside the CRYRING, which will act as a well-suited test bench for further optimization of the CCC performance and the cryostat. In the meantime...

  3. A short note on jackknifing the concordance correlation coefficient.

    Science.gov (United States)

    Feng, Dai; Baumgartner, Richard; Svetnik, Vladimir

    2014-02-10

    Lin's concordance correlation coefficient (CCC) is a very popular scaled index of agreement used in applied statistics. To obtain a confidence interval (CI) for the estimate of CCC, jackknifing was proposed and shown to perform well in simulation as well as in applications. However, a theoretical proof of the validity of the jackknife CI for the CCC has not been presented yet. In this note, we establish a sufficient condition for using the jackknife method to construct the CI for the CCC. Copyright © 2013 John Wiley & Sons, Ltd.

  4. Influence of oxygen, nitrogen and carbon on the lattice parameter of uranium mono-carbide; Influence de l'oxygene, de l'azote et du carbone sur le parametre reticulaire du monocarbure d'uranium

    Energy Technology Data Exchange (ETDEWEB)

    Magnier, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1966-04-15

    The author studies the influence of oxygen and nitrogen contents on the lattice parameter of U(C,O,N) solid solutions around UC composition. The whole data conducts to a determination of the solubility of oxygen in UC: a U(C(1-x)O(x)) solid solution exist if x if smaller than 0.37. The author studies also the influence of carbon content on the lattice parameter of U-UC solid solutions around UC. This study conducts to the determination of the solubility of U in UC at the different temperatures. Consequences upon uranium-carbon diagram are envisaged. (author) [French] L'auteur etudie quantitativement l'influence de l'oxygene et de l'azote sur le parametre reticulaire des solutions solides U(C,O,N) proches de UC. Cette etude permet la determination de la solubilite de l'oxygene dans UC: on montre l'existence d'une solution solide U(C(1-x)O(x)) lorsque x est compris entre 0 et 0,37. Par ailleurs l'auteur etudie l'influence de la teneur en carbone sur le parametre des solutions solides U-UC proches de UC. Cette etude permet la determination de la solubilite de l'uranium dans UC aux differentes temperatures. On envisage enfin les modifications apportees par cette etude au diagramme uranium-carbone. (auteur)

  5. A global analysis of the comparability of winter chill models for fruit and nut trees.

    Science.gov (United States)

    Luedeling, Eike; Brown, Patrick H

    2011-05-01

    Many fruit and nut trees must fulfill a chilling requirement to break their winter dormancy and resume normal growth in spring. Several models exist for quantifying winter chill, and growers and researchers often tacitly assume that the choice of model is not important and estimates of species chilling requirements are valid across growing regions. To test this assumption, Safe Winter Chill (the amount of winter chill that is exceeded in 90% of years) was calculated for 5,078 weather stations around the world, using the Dynamic Model [in Chill Portions (CP)], the Chilling Hours (CH) Model and the Utah Model [Utah Chill Units (UCU)]. Distributions of the ratios between different winter chill metrics were mapped on a global scale. These ratios should be constant if the models were strictly proportional. Ratios between winter chill metrics varied substantially, with the CH/CP ratio ranging between 0 and 34, the UCU/CP ratio between -155 and +20 and the UCU/CH ratio between -10 and +5. The models are thus not proportional, and chilling requirements determined in a given location may not be valid elsewhere. The Utah Model produced negative winter chill totals in many Subtropical regions, where it does not seem to be useful. Mean annual temperature and daily temperature range influenced all winter chill ratios, but explained only between 12 and 27% of the variation. Data on chilling requirements should always be amended with information on the location and experimental conditions of the study in which they were determined, ideally including site-specific conversion factors between winter chill models. This would greatly facilitate the transfer of such information across growing regions, and help prepare growers for the impact of climate change.

  6. Mersin Bitkisi (Myrtus communis L.'nde Farklı Hasat Zamanlarının

    Directory of Open Access Journals (Sweden)

    Ayşe Betül AVCI

    2009-04-01

    Full Text Available Bu çalışma Ege Üniversitesi Ziraat Fakültesi Bornova araştırma alanında bulunan Mersin (Myrtus communis L. bitkilerinde farklı hasat zamanlarının uçucu yağ oranlarına etkisini araştırmak amacıyla yürütülmüştür. Araştırmada, Mersin bitkisinden Ekim 2002 tarihinden itibaren bir yıl boyunca her ayın 15'inde ve günün üç farklı saatinde (08:00, 13:00, 18:00 olacak şekilde yapraklı dal örnekleri alınmıştır. Mersin (Myrtus communis L. bitkisinde en yüksek uçucu yağ oranı ortalama % 0.725 ile Temmuz ayında saat 18.00'de yapılan hasatta, en düşük oran ise ortalama % 0.250 ile mart ayında saat 13.00'de yapılan hasatta elde edildiği gözlenmiştir. Yapılan LSD testine göre farklı aylara ve saatlere göre belirlenen uçucu yağ değerleri arasındaki fark istatistiksel açıdan önemli bulunmuştur.

  7. MR spectroscopy of prostate cancer: correlation study of metabolic characters with Gleason score

    International Nuclear Information System (INIS)

    Wang Xiaoying; Li Feiyu; Jiang Xuexiang; Shan Gangzhi; Zhou Liangping; Ding Jianping

    2006-01-01

    Objective: Using magnetic resonance spectroscopy (MRS) to measure the metabolic ratio [(choline + creatine)/citrate, CC/C] of prostate cancer(PCa) and to probe the correlation between the value of CC/C ratio and Gleason score. Methods: Twenty-one cases of PCa proved by operation or systemic biopsy were examined by MRS. The prostate was divided into 6 regions (left/right bottom, middle and tip), and the CC/C value of each region was measured. After biopsy, all the puncture locations were marked and enrolled in one of the regions mentioned above and the Gleason scores were recorded. The ratio of CC/C measured by MRS was compared with Gleason score in the corresponding regions. Results: The average CC/C ratio of the 74 regions with PCa was 2.13±0.82, whereas the average CC/C ratio of the 52 regions without PCa was 0.59±0.20. The difference of CC/C value was statistically significant (t=7.72, P=0.00). The ratios of CC/C in the regions of PCa were correlated with Gleason score (r=0.659, P=0.01). In group 1 (Gleason score≥7), the average CC/C ratio was 2.61±0.79. However, in group 2 (Gleasonscore <7) the average CC/C ratio was 1.69±0.59. There was statistically difference between the two groups (t=3.06, P=0.01). Conclusion: The metabolic ratio of CC/C is correlated to the Gleason score of PCa. MRS may be a useful method to evaluate the malignancy of PCa noninvasively. (authors)

  8. Chinese University Students and Their Experiences of Acculturation at an Ethnic Christian Church

    Science.gov (United States)

    Sun, Xiaoyang; Rhoads, Robert A.

    2018-01-01

    This paper examines the experiences of Chinese international students from East Coast University (a pseudonym) in the United States through their participation in a Chinese ethnic-based Christian church (CCC). Employing ethnographic-based fieldwork, the study highlights how Chinese international students see their experiences in CCC as a source of…

  9. 1990-1991 Marketing Plan. Year II: Planning To Meet the Future.

    Science.gov (United States)

    Turcott, Frances; And Others

    In Maryland, Catonsville Community College's (CCC) 1990-91 marketing plan deals with the community's perceptions of the institution and strategies to improve CCC's image. Both the 1989-90 and 1990-91 plans targeted the same markets for special recruitment strategies; i.e., high school graduates with transfer plans, part-time adult students,…

  10. 7 CFR 1421.11 - Spot checks.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Spot checks. 1421.11 Section 1421.11 Agriculture... ASSISTANCE LOANS AND LOAN DEFICIENCY PAYMENTS FOR 2008 THROUGH 2012 General § 1421.11 Spot checks. (a) CCC... CCC access to the farm and storage facility as necessary to conduct collateral inspections, or “spot...

  11. 7 CFR 1427.21 - Settlement.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Settlement. 1427.21 Section 1427.21 Agriculture... § 1427.21 Settlement. (a) The settlement of cotton loans will be made by CCC on the basis of the quality... maximum storage credit rates as determined and announced by CCC. (b) For purposes of settlements for...

  12. Chlorocholine chloride residue distribution in eggs, breast and ...

    African Journals Online (AJOL)

    The distribution of chlorocholine chloride (CCC) residue or its metabolites in the meat and eggs of laying hens was studied using the 15N delta value (d15N) and 15N atom % derived from 15N-CCC containing diets. In a completely randomised design, 20 laying hens were divided into four groups allocated four different ...

  13. The Effects of a Modified Cover, Copy, Compare on Spelling Tests and in Written Compositions for Three Students with Specific Learning Disabilities

    Science.gov (United States)

    Goodman, Ashley; McLaughlin, T. F.; Derby, K. Mark; Everson, Mary

    2015-01-01

    Spelling skills are vital in teaching students to read and write effectively. One method to help students learn to spell words correctly is called cover, copy, and compare (CCC). This study was designed to evaluate the effects of using CCC on the spelling and writing skills of three students with learning disabilities. These skills were measured…

  14. The relationship of plasma decoy receptor 3 and coronary collateral circulation in patients with coronary artery disease.

    Science.gov (United States)

    Yan, Youyou; Song, Dandan; Liu, Lulu; Meng, Xiuping; Qi, Chao; Wang, Junnan

    2017-11-15

    Previously, decoy receptor 3 (DcR3) was found to be a potential angiogenetic factor, while the relationship of DcR3 with coronary collateral circulation formation has not been investigated. In this study, we aimed to investigate whether plasma decoy receptor 3 levels was associated with CCC formation and evaluate its predictive power for CCC status in patients with coronary artery disease. Among patients who underwent coronary angiography with coronary artery disease and had a stenosis of ≥90% were included in our study. Collateral degree was graded according to Rentrope Cohen classification. Patients with grade 2 or 3 collateral degree were enrolled in good CCC group and patients with grade 0 or 1 collateral degree were enrolled in poor CCC group. Plasma DcR3 level was significantly higher in good CCC group (328.00±230.82 vs 194.84±130.63ng/l, p<0.01) and positively correlated with Rentrope grade (p<0.01). In addition, plasma DcR3 was also positively correlated with VEGF-A. Both ROC (receiver operating characteristic curve) and multinomial logistical regression analysis showed that plasma DcR3 displayed potent predictive power for CCC status. Higher plasma DcR3 level was related to better CCC formation and displayed potent predictive power for CCC status. Copyright © 2017. Published by Elsevier Inc.

  15. Screening for pragmatic language impairment: the potential of the children’s communication checklist

    NARCIS (Netherlands)

    Ketelaars, M.P.; Cuperus, J.; van Daal, J.; Jansonius, K.; Verhoeven, L.

    2009-01-01

    The present study examines the validity of the Dutch Children's Communication Checklist (CCC) for children in kindergarten in a community sample, in order to assess the feasibility of using it as a screening instrument in the general population. Teachers completed the CCC for a representative sample

  16. Screening for pragmatic language impairment: The potential of the children's communication checklist

    NARCIS (Netherlands)

    Ketelaars, M.P.; Cuperus, J.M.; Daal, J.G.H.L. van; Jansonius-Schultheiss, K.; Verhoeven, L.T.W.

    2009-01-01

    The present study examines the validity of the Dutch Children's Communication Checklist (CCC) for children in kindergarten in a community sample, in order to assess the feasibility of using it as a screening instrument in the general population. Teachers completed the CCC for a representative sample

  17. 7 CFR 1436.16 - Foreclosure, liquidation, assumptions, sales or conveyance, or bankruptcy.

    Science.gov (United States)

    2010-01-01

    ... used to foreclose on the property. (3) For loans with movable collateral and no real estate lien, CCC... convey the collateral or property securing the loan to another eligible borrower, or the borrower is dead... or conveyance, or bankruptcy. (a) The collateral or land securing a loan may be sold by CCC whenever...

  18. 7 CFR 1436.14 - Taxes.

    Science.gov (United States)

    2010-01-01

    ... Taxes. The borrower must pay, when due, all real and personal property taxes that may affect CCC's security interest in all collateral or land securing the note evidencing the loan. To protect its interests, CCC may pay any unpaid taxes with respect to the collateral or land securing a loan made in accordance...

  19. Factors influencing compliance to tactical driver advice: an assessment using a think-aloud protocol

    NARCIS (Netherlands)

    Risto, Malte; Martens, Marieke Hendrikje

    2013-01-01

    Connected Cruise Control (CCC) is an in-car driver support systems that aims to improve throughput in dense motorway traffic by advising drivers how to drive. The system is currently under development within a HTAS project. It will integrate lane advice, headway advice and speed advice. CCC will not

  20. 7 CFR 1403.9 - Late payment interest and administrative charges.

    Science.gov (United States)

    2010-01-01

    ... apply: (i) To debts owed by Federal agencies and State and local governments. Interest on debts owed by... the rate of interest charged by the U.S. Treasury for funds borrowed by CCC on the day the debt became... shall be expressed as an annual rate of interest which CCC charges on delinquent debts. The late payment...

  1. 7 CFR 1488.6 - Amendments to financing agreement.

    Science.gov (United States)

    2010-01-01

    ... been delivered, CCC will consider requests to increase the amount of the sale registration value for... CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS FINANCING OF SALES OF AGRICULTURAL COMMODITIES Financing of Export Sales of Agricultural Commodities From Private Stocks Under CCC...

  2. 7 CFR 1405.9 - Commodity assessments.

    Science.gov (United States)

    2010-01-01

    ... Commodity assessments. (a) CCC will deduct from the proceeds of a marketing assistance loan an amount equal... collected in one of the following ways, as requested by the State, but not both: (i) When the proceeds of... the State. (2) CCC will deduct from the proceeds of a marketing assistance loan an amount equal to the...

  3. 75 FR 65423 - Crop Assistance Program

    Science.gov (United States)

    2010-10-25

    ... operating plan for individual or legal entity; (2) Average adjusted gross income statement for 2009; and (3... payment limits and adjusted gross income (AGI) limits that apply to other CCC and FSA programs apply to... attribution is done for other FSA and CCC programs. Payment and average adjusted gross income (AGI) limits...

  4. 7 CFR 1493.520 - Recovery of losses.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Recovery of losses. 1493.520 Section 1493.520... Supplier Credit Guarantee Program Operations § 1493.520 Recovery of losses. (a) Notification. Upon payment of loss to the exporter or the exporter's assignee, CCC will notify the importer of CCC's rights...

  5. 7 CFR 1493.320 - Recovery of losses.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Recovery of losses. 1493.320 Section 1493.320... Facility Guarantee Program (FGP) Operations § 1493.320 Recovery of losses. (a) Notification. Upon payment of loss to the exporter or the exporter's assignee, CCC will notify the foreign bank of CCC's rights...

  6. 78 FR 23539 - National Marine Fisheries Service, Pacific Fishery Management Council (Pacific Council); May 6...

    Science.gov (United States)

    2013-04-19

    ..., including: budget issues, CCC meeting protocols, Managing Our Nation's Fisheries 3 (MONF3) conference...: The meeting will be held at the Mayflower Renaissance Hotel, 1127 Connecticut Avenue NW., Washington... Fisheries III Conference 12 p.m.-1:30 p.m. Lunch 1:30-4 p.m. CCC Meeting Guidance Budget Issues 4-5 p.m. The...

  7. 78 FR 45494 - Notice of Second Sugar Purchase and Exchange for Re-export Program Credits

    Science.gov (United States)

    2013-07-29

    ... have saved CCC $66.9 million in Sugar Program costs by reducing the amount of sugar loan collateral... collateral for CCC loan, as the purpose of this action is to reduce the forfeitures of loan collateral under... of later acquiring the sugar through loan forfeiture under the Sugar Program. The purchase invitation...

  8. 7 CFR 1435.104 - Loan maintenance.

    Science.gov (United States)

    2010-01-01

    ... quality and quantity as collateral to satisfy the processor's loan indebtedness to CCC. CCC shall not assume any loss in quantity or quality of the loan collateral. (2) The processor is responsible for... and in-process sugar pledged as loan collateral need not be stored identity preserved. (4) When the...

  9. 7 CFR 1427.13 - Fees, charges and interest.

    Science.gov (United States)

    2010-01-01

    ... the loan collateral to CCC, the producer shall pay to CCC, at the rates that are specified in the... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COTTON Nonrecourse Cotton Loan and Loan Deficiency Payments § 1427.13 Fees, charges and interest. (a) A producer shall pay a nonrefundable loan...

  10. 7 CFR 1427.10 - Approved storage.

    Science.gov (United States)

    2010-01-01

    ... § 1427.10 Approved storage. (a) Eligible cotton may be pledged as collateral for loans only if stored at... receipt for any bale or bales of cotton pledged as collateral for a CCC loan must include the dates that... cotton pledged as collateral for a CCC loan that are stored outside, and (ii) Through their electronic...

  11. 7 CFR 1493.210 - Definition of terms.

    Science.gov (United States)

    2010-01-01

    ... States including goods which contain imported raw materials or imported components. U.S. services... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Facility Guarantee Program (FGP) Operations § 1493.210 Definition of terms. Terms set forth in this subpart...

  12. Hedgehog pathway as a potential treatment target in human cholangiocarcinoma.

    Science.gov (United States)

    Riedlinger, Dorothee; Bahra, Marcus; Boas-Knoop, Sabine; Lippert, Steffen; Bradtmöller, Maren; Guse, Katrin; Seehofer, Daniel; Bova, Roberta; Sauer, Igor M; Neuhaus, Peter; Koch, Arend; Kamphues, Carsten

    2014-08-01

    Innovative treatment concepts targeting essential signaling pathways may offer new chances for patients suffering from cholangiocarcinoma (CCC). For that, we performed a systematic molecular genetic analysis concerning the Hedgehog activity in human CCC samples and analyzed the effect of Hh inhibition on CCC cells in vitro and in vivo. Activation of the Hh pathway was analyzed in 50 human CCC samples using quantitative polymerase chain reaction (qPCR). The efficacy of Hh inhibition using cyclopamine and BMS-833923 was evaluated in vitro. In addition, the effect of BMS-833923, alone or in combination with gemcitabine, was analyzed in vivo in a murine subcutaneous xenograft model. Expression analysis revealed a significant activation of the Hh-signaling pathway in nearly 50% of CCCs. Hh inhibition resulted in a significant decrease in cell proliferation of CCC cells. Moreover, a distinct inhibition of tumor growth could be seen as a result of a combined therapy with BMS-833923 and gemcitabine in CCC xenografts. The results of our study suggest that the Hh pathway plays a relevant role at least in a subset of human CCC. Inhibition of this pathway may represent a possible treatment option for CCC patients in which the Hh pathway is activated. © 2014 Japanese Society of Hepato-Biliary-Pancreatic Surgery.

  13. Critical Community Conversations: Cultivating the Elusive Dialogue about Racism with Parents, Community Members, and Teachers

    Science.gov (United States)

    Love, Bettina L.; Muhammad, Gholnecsar E.

    2017-01-01

    This article highlights how two researchers started Critical Community Conversations (CCC) with a school community in an effort to learn from one another and build solidarity. The intent was for CCC to focus on some of the most pressing issues facing our nation, state, and local neighborhoods, with a special lens on racism.

  14. 7 CFR 1485.18 - Advances.

    Science.gov (United States)

    2010-01-01

    ... operates MAP and EIP/MAP on a reimbursable basis. CCC will not advance funds to an EIP/MAP participant or... generic activity budget. However, CCC will not make any advance to an MAP participant where an advance is... 7 Agriculture 10 2010-01-01 2010-01-01 false Advances. 1485.18 Section 1485.18 Agriculture...

  15. 23P excitation of helium by electron impact

    International Nuclear Information System (INIS)

    Roeder, J.; Ehrhardt, H.; Bray, I.; Fursa, D.

    1996-03-01

    We present highly accurate relative measurements of 23P excitation of helium by electron impact at 30, 40 and 50 eV. These, when normalised to the convergent close-coupling (CCC) theory at one angle, yield excellent agreement at the remaining angles. This resolves some of the outstanding discrepancies between the CCC theory and earlier measurements. (authors). 14 refs., 3 figs

  16. 5 CFR 1315.13 - Commodity Credit Corporation payments.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Commodity Credit Corporation payments... PAYMENT § 1315.13 Commodity Credit Corporation payments. As provided in § 1315.1(d), the provisions of... Credit Corporation (CCC) pursuant to Section 4(h) of the Act of June 29, 1948 (15 U.S.C. 714b(h)) (“CCC...

  17. 7 CFR 1488.8 - Documents required after delivery.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Documents required after delivery. 1488.8 Section... delivery. (a) CCC will purchase an exporter's account receivable only if the Treasurer, Commodity Credit... or Assistant Treasurer, CCC, after date of delivery of commodities exported or to be exported under...

  18. 7 CFR 1493.470 - Evidence of export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Evidence of export. 1493.470 Section 1493.470... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Supplier Credit Guarantee Program Operations § 1493.470 Evidence of export. (a) Report of export. The...

  19. 7 CFR 1493.280 - Evidence of export report.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Evidence of export report. 1493.280 Section 1493.280... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Facility Guarantee Program (FGP) Operations § 1493.280 Evidence of export report. (a) Report of export. The...

  20. Association of conjunctival and corneal calcification with vascular calcification among hepatitis-C-seropositive hemodialysis patients.

    Science.gov (United States)

    AbouSeif, Khaled; Sany, Dawlat; Elshahawy, Yasser; Seddik, Ayman; Rahman, Khedr; Gaber, Moustapha

    2016-01-01

    Disorders associated with the hepatitis C virus (HCV) have been reported including cardiovascular, metabolic, and central nervous system diseases. Since chronic HCV infections may be curable, their identification as causal contributors to cardiovascular risk could offer new perspectives in the prevention of cardiovascular disease. The aim of this study is to investigate the association between HCV and aortic arch calcification (AAC) and corneal and conjunctival calcification (CCC) in maintenance hemodialysis (MHD) patients; further, we assessed the correlation of CCC with vascular calcification. A total of 100 patients undergoing hemodialysis (HD) in our hospital were included in this study. Patients underwent a complete ocular examination including intraocular pressure, and CCC was looked for by slit lamp and fundoscopy. CCC was graded according to modified Porter and Crombie classification system described by Tokuyama et al. Helical computerized tomographic chest examination was used to evaluate the grading of AAC. Demographic, hematological, biochemical, and dialysis-related data were obtained. There was significant difference between seropositive (n = 51) and seronegative patients (n = 49) regarding grading of AAC and CCC (P <0.001). Significant positive correlation was found between grading of CCC, AAC, age (P <0.001), duration on HD (P <0.001), HCV-antibody positivity (P <0.001), serum calcium level (P <0.001), serum phosphorus level (P <0.001), calcium × phosphorus product (P <0.001), and i-parathormone level (P < 0.001). In addition, CCC grading positively correlated with AAC. Our results suggest that patients undergoing HD infected with the HCV have high degree of CCC, AAC, and mineral metabolism disorder. The strong correlation between CCC and AAC indicates that CCC evaluation is an easy, fast, non-invasive method, and might be used as an indirect indicator to detect vascular calcification in patients undergoing MHD.

  1. Association of conjunctival and corneal calcification with vascular calcification among hepatitis-C-seropositive hemodialysis patients

    Directory of Open Access Journals (Sweden)

    Khaled AbouSeif

    2016-01-01

    Full Text Available Disorders associated with the hepatitis C virus (HCV have been reported including cardiovascular, metabolic, and central nervous system diseases. Since chronic HCV infections may be curable, their identification as causal contributors to cardiovascular risk could offer new perspectives in the prevention of cardiovascular disease. The aim of this study is to investigate the association between HCV and aortic arch calcification (AAC and corneal and conjunctival calcification (CCC in maintenance hemodialysis (MHD patients; further, we assessed the correlation of CCC with vascular calcification. A total of 100 patients undergoing hemodialysis (HD in our hospital were included in this study. Patients underwent a complete ocular examination including intraocular pressure, and CCC was looked for by slit lamp and fundoscopy. CCC was graded according to modified Porter and Crombie classification system described by Tokuyama et al. Helical computerized tomographic chest examination was used to evaluate the grading of AAC. Demographic, hematological, biochemical, and dialysis-related data were obtained. There was significant difference between seropositive (n = 51 and seronegative patients (n = 49 regarding grading of AAC and CCC (P <0.001. Significant positive correlation was found between grading of CCC, AAC, age (P <0.001, duration on HD (P <0.001, HCV-antibody positivity (P <0.001, serum calcium level (P <0.001, serum phosphorus level (P <0.001, calcium × phosphorus product (P <0.001, and i-parathormone level (P < 0.001. In addition, CCC grading positively correlated with AAC. Our results suggest that patients undergoing HD infected with the HCV have high degree of CCC, AAC, and mineral metabolism disorder. The strong correlation between CCC and AAC indicates that CCC evaluation is an easy, fast, non-invasive method, and might be used as an indirect indicator to detect vascular calcification in patients undergoing MHD.

  2. Yabani Hardal (Sinapsis arvensis L. Tohumu ve Yağlarının Bazı Bileşim Özellikleri

    Directory of Open Access Journals (Sweden)

    Musa Özcan

    2015-02-01

    Full Text Available Tohum örneğinde bin tane ağırlığı ve irilik, su, ham kül, protein, yağ ve selüloz uçucu yağ miktarları belirlenmiştir. Tohum yağında nispi yoğunluk, kırılma indisi, serbest yağ asitleri, peroksit sayısı, iyot sayısı, sabunlaşma sayısı ve sabunlaşmayan madde tayin edilmiştir. Gaz kromatografisi yöntemiyle %0.25 uçucu yağda %95.40 allil izotiyosiyanat, %22.52 sabit yağda başlıca; %29.62 oleik, %24.18 linoleik, %20.65 erüsik ve %16.52 linolenik asitler saptanmıştır.

  3. SU iÇERiSiNDE AGIRLIGI DiKKATE ALINAN BiR KOLONUN BURKULMA ANALiZi

    Directory of Open Access Journals (Sweden)

    Yeliz PEKBEY

    2008-02-01

    Full Text Available EULER, 1744 yılında sabit enine kesitli çubukların kritik burkulma kuvvetlerini, çubuk agırlıgını ihmal ederek hesaplamıstır. Daha ekonomik çubuklar için, çubuk agırlıgının da dikkate alınması ve çözüm yapılması gerekir. Literatürde, 10 degisik mesnetleme durumu için çubuk agırlıgı da dikkate alınarak hava ortamında kritik burkulma kuvvetleri ve asimptotik burkulma kuvvetleri hesaplanmıs ve bu kuvvetlerden hareketle 4 mesnetleme durumu için sudaki kritik kuvvetlerin bulunabilecegi, diger 6 mesnetleme durumuna ait sudaki kritik burkulma kuvvetlerinin ise hava ortamındakinden hesaplanamayacagı belirtilmistir. Bu çalısmada, bugüne kadar kritik burkulma kuvvetleri hesaplanmamıs, su içerisinde, üst ucu ankastre mesnetli alt ucu ankastreli kayıcı mesnetli çubuk için çözüm verilmistir.

  4. Non-Fermi liquid scaling in UPdxCu5-x(x = 1,1.5)

    International Nuclear Information System (INIS)

    Aronson, M.C.; Osborn, R.; Lynn, J.W.; Chau, R.; Seaman, C.L.; Maple, M.B.

    1994-08-01

    The family of uranium based intermetallics UPd x Cu 5-x offers an ideal isostructural system to study the interplay of the impurity Kondo effect with the stability of long range magnetic order in a Kondo lattice. The parent compound UCu 5 is a prototypical Kondo impurity system at high temperatures, with Kondo temperature T K ∼ 5--10 meV. As the temperature is lowered, intersite interactions drive a transition to long-range antiferromagnetic order of the incompletely compensated uranium moments at 15 K. As Pd is substituted on the Cu sites, the antiferromagnetism is suppressed, with the ordering temperature driven to zero slightly below the composition UPdCu 4 . Unusual temperature and magnetic field scaling is observed in the magnetization, specific heat, and electrical resistivity of both UPdCu 4 and UPd 1.5 Cu 3.5 , inconsistent with the Fermi liquid description appropriate for many Kondo lattice systems, and in particular the parent compound UCu 5 . The authors report here the first direct measurements of the fundamental magnetic response for both compounds, providing a clear demonstration of non-Fermi liquid frequency and temperature scaling

  5. Menemen Ekolojik Koşullarında Lavanta (Lavandula spp.) Tür ve Çeşitlerinin Morfolojik, Verim ve Kalite Özelliklerinin Belirlenmesi

    OpenAIRE

    Karık, Ünal; Çiçek, Fatih; Çınar, Orçun

    2017-01-01

    Bu çalışma Menemen ekolojik koşullarında lavanta (Lavandula spp.) tür ve çeşitlerininmorfolojik, verim ve kalite özelliklerini belirlemek amacı ile 2015-2016yılları arasında yürütülmüştür. Çalışmada 2 farklı türe ait 8 farklı ticarilavanta çeşidi kullanılmıştır. 2 yıl sonucunda elde edilen veriler ışığında türve çeşitler arasında önemli farklılıklar bulunduğu tespit edilmiştir. Lavandintipi çeşitler, verim özellikleri açısından lavander tipi çeşitlerin önünegeçerken,  uçucu yağ oranı ve uçucu...

  6. Retinoid X Receptor α-Dependent HBV Minichromosome Remodeling and Viral Replication.

    Science.gov (United States)

    Zhang, Yan; He, Song; Guo, Jin-Jun; Peng, Hong; Fan, Jia-Hao; Li, Qing-Ling

    2017-01-01

    The HBV covalently closed circular DNA (cccDNA) is organized into a minichromosome in the nuclei of infected hepatocytes through interactions with histone and nonhistone proteins. Retinoid X receptor α (RXRα), a liver-enriched nuclear receptor, participates in regulation of HBV replication and transcription through modulation of HBV enhancer 1 and core promoter activity. This study investigated RXRα involvement in HBV cccDNA epigenetic modifications. Quantitative cccDNA chromatin immunoprecipitation (ChIP) was applied to study the recruitment of RXRα, histones, and chromatin-modifying enzymes to HBV minichromosome in HepG2 cells after transfection of the linear HBV genome. RXRα Was found to directly bind to HBV cccDNA; recruitment of RXRα to HBV mini-chromosome paralleled HBV replication, histone recruitment, and histone acetylation in HBVcccDNA. Moreover, RXRα overexpression or knock-down significantly increased or impaired the recruitment of the p300 acetyltransferase to cccDNAminichromosome. Our results confirmed the regulation of RXRα on HBV replication in vitro and demonstrated the modulation of RXRα on HBV cccDNA epigenetics. These findings provide a profound theoretical and experimental basis for late-model antiviral treatment acting on the HBV cccDNA and minichromosome.

  7. Visualization of coronary arteries in patients after childhood Kawasaki syndrome: value of multidetector CT and MR imaging in comparison to conventional coronary catheterization

    International Nuclear Information System (INIS)

    Arnold, Raoul; Ley, Sebastian; Ley-Zaporozhan, Julia; Kauczor, Hans-Ulrich; Eichhorn, Joachim; Ulmer, Herbert; Schenk, Jens-Peter

    2007-01-01

    After childhood Kawasaki syndrome (KS) the coronary arteries undergo a lifelong dynamic pathological change, and follow-up coronary artery imaging is essential. At present, conventional coronary catheterization (CCC) and angiography is still regarded as the gold standard. Less-invasive methods such as multidetector CT angiography (MDCT-A) and MRI have been used sporadically. To compare the diagnostic quality of MDCT-A and MRI with that of CCC for coronary imaging in a group of patients with coronary artery pathology after childhood KS. A total of 16 patients (aged 5-27 years) underwent CCC and 16-row MDCT-A and 14 patients MRI (1.5 T). There was 100% agreement between MDCT-A and CCC in the detection of coronary aneurysms and stenoses. MDCT-A was superior for the visualization of calcified lesions. MRI and CCC showed 93% agreement for the detection of aneurysms. Visualization of coronary artery stenoses was difficult using MRI - one stenosis was missed. MDCT-A has excellent correlation with CCC regarding all changes affecting the coronary arteries in the follow-up of childhood KS. In comparison to MDCT-A and CCC, MRI is less precise in the detection of stenotic lesions. Due to its high image quality and ease of performance MDCT-A should be the primary diagnostic modality in patients following childhood KS. (orig.)

  8. Potential of plant growth regulator and chlormequat chloride on alfalfa seed components

    International Nuclear Information System (INIS)

    Chen, J. S.; Lin, H.; Han, W.

    2016-01-01

    The use of plant growth regulators (PGRs) has opened new prospects for increased seed production in grasses and legumes, but little information is available on the effects of PGRs combination with chlormequat chloride (CCC) on alfalfa (Medicago sativa L.) seed yield components. This study was conducted to evaluate the effects of applying chlormequat chloride in combination with three PGRs (Naphthylacetic acid (NAA), gibberellic acid 3 (GA), and brassinolide (BR)) on seed yield, aboveground biomass, plant height, lodging, yield components. CCC was applied annually at the stooling stage while three PGRs were applied twice each year at the stages of flower bud formation and peak flowering. Results provides evidence that: (i) each PGR consistently increased seed yields, and the numbers of seeds per stem compared to untreated plants; (ii) CCC treatment reduced plant height and lodging, but also significantly decreased seed yield and did not affect aboveground biomass. (iii) effectiveness of CCC application depends on climatic conditions, especially in North-east China. (iiii) the optimum combination of CCC with a PGR to increase alfalfa seed production was failed to identify. (iiiii) no interactions between PGRs and CCC on seed yield were observed and neither the PGRs nor the CCC. But alfalfa seed yield could be improved by combining a PGR such as NAA. Our Results suggest that these PGRs could be used in alfalfa breeding to increase seed yield while maintaining high seed quality. (author)

  9. Non-intercepting beam intensity measurements towards pico-ampere. Cryogenic current comparators for FAIR

    Energy Technology Data Exchange (ETDEWEB)

    Kurian, Febin [GSI Helmholtzzentrum fuer Schwerionenforschung (Germany); Goethe University, Frankfurt am Main (Germany); Helmholtz Institute Jena (Germany); Schwickert, Marcus; Sieber, Thomas; Kowina, Piotr; Reeg, Hansjoerg [GSI Helmholtzzentrum fuer Schwerionenforschung (Germany); Geithner, Rene; Neubert, Ralf; Seidel, Paul; Golm, Jessica [Friedrich-Schiller-Universitaet Jena (Germany); Stoehlker, Thomas [GSI Helmholtzzentrum fuer Schwerionenforschung (Germany); Helmholtz Institute Jena (Germany); Friedrich-Schiller-Universitaet Jena (Germany)

    2016-07-01

    To satisfy the requirement of non-interceptive measurement of beam intensity down to nA range foreseen in the upcoming FAIR accelerator facility, several Cryogenic Current Comparator (CCC) systems are planned to be installed in its beam transfer lines and storage rings. As a test bench for the development of advanced CCC systems for these installations, the existing CCC system at GSI has been recommissioned and upgraded with advanced sensor components. Successful beam intensity measurements using this upgraded CCC system will be reported in this contribution. Apart from the beam measurements, several operational aspects of the CCC system were investigated, such as the baseline drifts and various noise influences. Combining the operational experiences and boundary conditions given at various installation locations in the FAIR facility, an advanced CCC system is currently under development and is planned to be installed at the Cryring facility at GSI for test measurements. Details on the development of this advanced CCC system will also be presented in this contribution.

  10. Comparative study on Ti/Zr/V and chromate conversion treated aluminum alloys: Anti-corrosion performance and epoxy coating adhesion properties

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Wen; Li, Wenfang, E-mail: mewfli@163.com; Mu, Songlin; Fu, Nianqing; Liao, Zhongmiao

    2017-05-31

    Highlights: • The surface roughness and surface free energy of the AA6063 are significantly increased after TZVCC treatment. • The anti-corrosion performance of the AA6063 is effectively enhanced after TZVCC treatment. • Both the corrosion resistance and wet adhesion properties of the epoxy coating on the AA6063 are noticeably improved after TZVCC treatment. - Abstract: In this study, a Ti/Zr/V conversion coating (TZVCC) was deposited on the surface of aluminum alloy 6063 (AA6063) as an alternative of the chromate conversion coating (CCC). Both the TZVCC treated AA6063 (TZVCC/AA6063) and CCC treated AA6063 (CCC/AA6063) were characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), atomic force microscope (AFM) and contact angle measuring device. The anti-corrosion performance of the TZVCC/AA6063 and CCC/AA6063 was evaluated by electrochemical measurements and neutral salt spray tests. It showed that both the surface roughness and surface free energy of the AA6063 were significantly increased after TZVCC treatment. The anti-corrosion performance of TZVCC/AA6063 was superior to that of CCC/AA6063. In addition, the effects of the TZVCC and CCC on the adhesion properties and anti-corrosion performance of epoxy coating applied on samples were examined by pull-off tests and electrochemical impedance spectroscopy (EIS). The dry, wet and recovery adhesive strengths of the epoxy coating on TZVCC treated samples (epoxy coated TZVCC/AA6063) were very close to those of epoxy coating on CCC treated ones (epoxy coated CCC/AA6063). The epoxy coated TZVCC/AA6063 showed better corrosion resistance than the epoxy coated CCC/AA6063 and epoxy coated AA6063.

  11. Angiotensin-converting enzyme DD polymorphism is associated with poor coronary collateral circulation in patients with coronary artery disease.

    Science.gov (United States)

    Ceyhan, Koksal; Kadi, Hasan; Celik, Atac; Burucu, Turgay; Koc, Fatih; Sogut, Erkan; Sahin, Semsettin; Onalan, Orhan

    2012-01-01

    Although association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and cardiovascular diseases was reported by many studies, the relation between ACE I/D polymorphism and coronary collateral circulation (CCC) has not been studied yet. The aim of the present study was to investigate a possible relationship between ACE I/D polymorphism and CCC. Patients who were subjected to coronary angiography in the 2006 to 2009 period and had at least a completely occluded major artery were included in this study. To classify collateral circulation, we used the Rentrop classification. Patients were classified as having poor CCC (Rentrop grades 0 to 1) or good CCC (Rentrop grades 2 to 3). Gene polymorphism was detected through the detailed melting curve analysis of polymerase chain reaction products after amplification using real-time polymerase chain reaction method and LightCycler 1.5 apparatus. We prospectively studied 113 patients who had at least 1 totally occluded major epicardial coronary artery. Forty-seven patients had poor CCC and 67 patients had good CCC. There were no differences among groups in age, sex, risk factors, lipid profile, uses of cardiovascular drugs, and number of diseased vessels. Plasma ACE levels were significantly higher in poor CCC group (P DD polymorphism was higher in the poor CCC group (P DD genotype (95% CI, 2.55-12.79; P = 0.001), presence of diabetes (95% CI, 1.03-3.16; P = 0.005), and pulse pressure (95% CI, 1.04-1.56; P = 0.045) were independent determinants of poor coronary collateral development. This study showed that ACE DD polymorphism is associated with poor CCC. Poor collateral circulation in patients carrying the D allele may be associated with endothelial dysfunction and elevated blood ACE levels in these patients.

  12. Cervi cornus Colla (deer antler glue) induce epidermal differentiation in the reconstruction of skin equivalents.

    Science.gov (United States)

    Choi, H-R; Nam, K-M; Kim, D-S; Huh, C-H; Na, J-I; Park, K-C

    2013-06-01

    In the reconstruction of skin equivalents (SEs), keratinocyte differentiation is important because epidermal differentiation is closely related with barrier function. The aim of this study was to investigate the effects of Cervi cornus Colla (CCC) on the stem cell activity and epidermal differentiation in the reconstruction of skin equivalent. Four different models were constructed according to different composition of dermal substitute. Results showed similar morphologic findings when hyaluronic acid (HA) and/or CCC was added. But, immunohistochemical staining showed that p63 was significantly increased by addition of HA and/or CCC. Increased staining of integrin α6 and β1 was variably observed when HA and/or CCC was added to make dermal substitute. These finding showed that addition of HA and/or CCC may affect the stem cell activity in the reconstruction of skin. Furthermore, filaggrin expression was much increased when CCC was added. It showed that epidermal differentiation was significantly improved by addition of CCC. In conclusion, simultaneous presence of HA and CCC contributed to the stem cell activity and epidermal differentiation in the reconstruction of SE. Legislation in the EU prohibits marketing cosmetics and personal care products that contain constituents that have been examined through animal experiments. To avoid these limitations, SEs can be used for testing the safety or the efficacy of cosmetic ingredients. Therefore, our results showed that combined use of HA and CCC can be helpful for the reconstruction of SE with good stem cell activity and epidermal differentiation. © 2013 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

  13. Temporal variation of clear-water scour at compound Abutments

    Directory of Open Access Journals (Sweden)

    Aminuddin Ab. Ghani

    2016-12-01

    Full Text Available Most of actual abutments in rivers are built on foundation, while there is limited number of study available on the effects of the foundation on the local scour. In this study, temporal variation of local scour around compound abutment was investigated experimentally under clear-water conditions. The results showed that a suitable level of foundation is able to decrease the scour depth and increase scour time during the flood events. The trend of temporal scour depth at compound pier and abutment is similar. The scour depth develops to top of foundation quickly, and then the foundation postpones the scour development (lag–time. Duration of lag–time depends on the foundation level, velocity ratio (U/Uc and foundation dimension. This study highlights that proper design of foundation level increases duration of scouring and provides enough time to treat bridge foundation after the flood events.

  14. Demographic Clinical and Prognostic Factors of Primary Ovarian Adenocarcinomas of Serous and Clear Cell Histology—A Comparative Study

    DEFF Research Database (Denmark)

    Schnack, Tine H; Høgdall, Estrid; Nedergaard, Lotte

    2016-01-01

    -based prospectively collected data on oCCC (n = 179) and oSAC (n = 2363) cases were obtained from the Danish Gynecological Cancer Database. χ, Fischer or Wilcoxon-Mann-Whitney, multivariate logistic regression, univariate Kaplan-Meier, and multivariate Cox regression tests were used. Statistical tests were 2-sided. P......, 0.62; 95% confidence interval, 0.37-0.92).Although more oSAC than oCCC cases diagnosed in stage III or IV were referred to neoadjuvant chemotherapy, a higher proportion of oCCC achieved complete cytoreduction at primary debulking surgery and/or had lymphadenectomy performed; overall survival were...

  15. Contribution to the study of the uranium-hydrogen system; Contribution a l'etude du systeme uranium-hydrogene

    Energy Technology Data Exchange (ETDEWEB)

    Chevallier, J [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1965-01-01

    Previous work on uranium-hydrogen system is reviewed. The U-H{sub 2}-UH{sub n} equilibrium is then investigated at pressures below one atmosphere, i.e. at temperatures lower than 430 deg. C. The hydride obtained at equilibrium is deficient in hydrogen (UH{sub n<3}), the hydrogen deficit increasing as the temperature rises. Thermodynamic functions for the formation of non-stoichiometric hydride and of one hydrogen vacancy are derived from pressure composition isotherms, in U-H phase diagram is proposed. The hydrogenation of U-UC alloys is also examined at pressures below one atmosphere with regard to the equilibrium: (free U + UC) - H{sub 2}-UH{sub n}. The equilibrium conditions are found different from that observed for pure uranium. (author) [French] Une etude bibliographique du systeme uranium-hydrogene est exposee. L'equilibre U-H{sub 2}-UH{sub n} est ensuite etudie sous des pressions inferieures a une atmosphere, soit aux temperatures inferieures a environ 430 degs. C. L'hydrure obtenu a l'equilibre est deficitaire en hydrogene - UH{sub n<3} - et d'autant plus que la temperature s'eleve. Les grandeurs thermodynamiques relatives a la formation et a la saturation de l'hydrure, ainsi qu'a la formation d'une lacune d'hydrogene sont deduites des pressions d'equilibre. Un modele de diagramme de phases U-H est propose. L'hyduration des alliages U-UC est etudiee egalement sous des pressions inferieures a l'atmosphere, au point de vue de l'equilibre (U libre + UC) - H{sub 2}-UH{sub n}. Les conditions d'equilibre sont trouvees differentes de celles observees sur l'uranium pur. (auteur)

  16. Method to generate the first design of the reload pattern to be used with the Presto-B code in the simulation of the CNLV U-1 reactor

    International Nuclear Information System (INIS)

    Montes T, J.L.; Cortes C, C.C.

    1992-08-01

    This guide is applied for the reload pattern's formation for mirror symmetry of a core room and in accordance with the Control Cell core technique (of the english Control Cell Core - CCC) for the PRESTO-B code. (Author)

  17. 7 CFR 1425.5 - Confidentiality.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COOPERATIVE MARKETING ASSOCIATIONS § 1425.5 Confidentiality. Information submitted to CCC related to trade secrets, financial or commercial operations, or the financial...

  18. 7 CFR 1465.3 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... CCC. Nonindustrial private forest land means rural land that has existing tree cover or is suitable..., filterstrips, critical area plantings, tree plantings, establishment or improvement of wildlife habitat, and...

  19. ONLINE RESOURCES

    Indian Academy of Sciences (India)

    Navya

    Low genetic diversity of the endangered Indian wild ass Equus hemionus khur, as revealed by microsatellite ... species of the Asiatic wild asses, Equus hemionus and Equus kiang, have been .... 5'-TCA CCC ACT AAA TCT CAA ATC C-3'.

  20. Treatment results and prognostic factors of clear cell ovarian carcinomas and ovarian carcinomas with clear cell component

    Directory of Open Access Journals (Sweden)

    M. D. Ahmedova

    2012-01-01

    Full Text Available The most important prognostic factors for clear cell carcinoma (CCC are clinical and morphological signs and clinical stage of the disease. Analyses of 5-year survival in patients with I stage of CCC is 69 %, in II stage – 55 %, in III stage – 14 % and in IV stage – 4 % patients. We analyzed distant results of treatment of 71 patients with CCC and of 25 patients with mixed malignant ovaries neoplasm with obligatory clear cell component taking into consideration main clinical and morphological sings of disease. On the base of performed reseal we revealed that morphological structure of the tumors and stage of the disease exerted heist influence on the exponent of survival of the patients with clear CCC ovaries neoplasm. Besides, there is a correlation between exponent of patients’ survival and radicalized of surgery, character of tumor growth, differentiation degree, cell anaplasia and mitotic activity of tumor cells.

  1. 7 CFR 1437.310 - Sea grass and sea oats.

    Science.gov (United States)

    2010-01-01

    ...) Irrigation and water quality; (5) Weed control; (6) Pest and disease control; (7) Rodent and wildlife control... a region or controlled environment conducive to successful production, as determined by CCC; and (2...

  2. 7 CFR 1468.21 - Contract requirements.

    Science.gov (United States)

    2010-01-01

    ... net environmental and societal benefits; (ii) Refund with interest any program payments received and... under the CFO contract; (v) Supply information as required by CCC to determine compliance with the...

  3. 7 CFR 1499.5 - Agreements.

    Science.gov (United States)

    2010-01-01

    ... designed to ensure that the participant is aware of, and has the capacity to complete, all required... provide donated commodities and CCC-provided funds under a multiyear agreement contingent upon the...

  4. Can the Children's Communication Checklist differentiate within the autistic spectrum?

    NARCIS (Netherlands)

    Verte, S; Geurts, H.M.; Roeyers, H.; Rosseel, Y.; Oosterlaan, J.; Sergeant, J.A.

    2006-01-01

    The study explored whether children with high functioning autism (HFA), Asperger syndrome (AS), and pervasive developmental disorder not otherwise specified (PDD-NOS) can be differentiated on the Children's Communication Checklist (CCC). The study also investigated whether empirically derived

  5. 7 CFR 1403.11 - Administrative appeal.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT... within 15 days of the date of CCC's initial demand letter, unless a longer period is specified in the initial demand letter. [56 FR 66956, Dec. 27, 1991] ...

  6. A squid-based beam current monitor for FAIR/CRYRING

    International Nuclear Information System (INIS)

    Geithner, Rene; Stöhlker, Thomas; Kurian, Febin; Reeg, Hansjörg; Schwickert, Marcus; Neubert, Ralf; Seidel, Paul

    2015-01-01

    A SQUID-based beam current monitor was developed for the upcoming FAIR-Project, providing a non-destructive online monitoring of the beam currents in the nA-range. The cryogenic current comparator (CCC) was optimized for lowest possible noise-limited current resolution together with a high system bandwidth. This CCC is foreseen to be installed in the CRYRING facility (CRYRING@ESR: A study group report www.gsi.de/fileadmin/SPARC/documents/Cryring/ReportCryring-40ESR.PDF), working as a test bench for FAIR. In this contribution we present results of the completed CCC for FAIR/CRYRING and also arrangements that have been done for the installation of the CCC at CRYRING, regarding the cryostat design. (paper)

  7. 76 FR 21323 - Notice of Funds Availability: Inviting Applications for the Technical Assistance for Specialty...

    Science.gov (United States)

    2011-04-15

    ... through the Unified Export Strategy (UES): Organizations are strongly encouraged to submit their..., or other promotional expenses, as set forth in the written program agreement between CCC and the...

  8. 7 CFR 1434.14 - Loss or damage.

    Science.gov (United States)

    2010-01-01

    ... the honey pledged as collateral for a loan. CCC shall not assume any loss in quantity or quality of the loan collateral. ... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS NONRECOURSE MARKETING ASSISTANCE LOAN AND LDP REGULATIONS...

  9. 7 CFR 1435.303 - Adjustment of the overall allotment quantity.

    Science.gov (United States)

    2010-01-01

    ...) To avoid forfeiture of sugar loan collateral to CCC, (2) Ensure adequate supplies of raw and refined... CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS SUGAR PROGRAM...

  10. Electron-impact ionization doubly differential cross sections of helium

    International Nuclear Information System (INIS)

    Bray, Igor; Fursa, Dmitry V; Stelbovics, Andris T

    2003-01-01

    The convergent close-coupling (CCC) method is applied to the calculation of electron-helium ionization doubly differential cross sections (DDCSs) at low to intermediate incident energies. We re-examine the CCC calculations and measurements of Roeder et al (1997 J. Phys. B: At. Mol. Opt. Phys. 30 1309-22) by making allowance for the step-function behaviour of the underlying CCC-calculated amplitudes. As done previously, the experimental DDCS were normalized at energies below 100 eV using the 100 eV CCC calculation to determine analyser properties at several secondary energies. In addition, substantially larger calculations are presented, to check the convergence. The agreement between the experiment and the calculations as a whole is much improved on the situation reported earlier

  11. Demographic, Clinical, and Prognostic Factors of Ovarian Clear Cell Adenocarcinomas According to Endometriosis Status

    DEFF Research Database (Denmark)

    Schnack, Tine H; Høgdall, Estrid; Thomsen, Lotte Nedergaard

    2017-01-01

    OBJECTIVES: Women with endometriosis carry an increased risk for ovarian clear cell adenocarcinomas (CCCs). Clear cell adenocarcinoma may develop from endometriosis lesions. Few studies have compared clinical and prognostic factors and overall survival in patients diagnosed as having CCC according...... to endometriosis status. METHODS: Population-based prospectively collected data on CCC with coexisting pelvic (including ovarian; n = 80) and ovarian (n = 46) endometriosis or without endometriosis (n = 95) were obtained through the Danish Gynecological Cancer Database. χ Test, independent-samples t test, logistic...... regression, Kaplan-Meier test, and Cox regression were used. Statistical tests were 2 sided. P values less than 0.05 were considered statistically significant. RESULTS: Patients with CCC and pelvic or ovarian endometriosis were significantly younger than CCC patients without endometriosis, and a higher...

  12. The 9th International Countercurrent Chromatography Conference held at Dominican University, Chicago, USA, August 1-3, 2016.

    Science.gov (United States)

    Friesen, J Brent; McAlpine, James B; Chen, Shao-Nong; Pauli, Guido F

    2017-10-20

    The 9th International Countercurrent Chromatography Conference (CCC 2016) was held at Dominican University near Chicago, IL (USA), from August 1st-3rd, 2016. The biennial CCC 20XX conferences provide an opportunity for countercurrent chromatography and centrifugal partition chromatography (CCC/CPC) manufactures, marketers, theorists, and research scientists to gather together socially, learn from each other, and advance countercurrent separation technology. A synopsis of the conference proceedings as well as a series of short reviews of the special edition articles is included in this document. Many productive discussions and collegial conversation at CCC 2016 attested to the liveliness, connectivity, and productivity of the global countercurrent research community and bodes well for the success of the 10th conference at the University of Braunschweig, Germany on August 1-3, 2018. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Sitewide Monitoring at Agra, Kansas, in 2015

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-05-01

    The CCC/USDA is currently implementing a KDHE-approved interim measure (IM) to address the contamination identified on its former property. This source control IM consists of large-diameter boreholes coupled with soil vapor extraction (SVE) and air sparging (AS). The CCC/USDA completed installation of the IM in May 2009. Assessment of the performance and effectiveness of the IM is being reported separately. Pro-Ag is conducting its own site investigation (KDHE 2011c).

  14. Ramona, Kansas, Corrective Action Monitoring Report for 2015

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-04-01

    This report describes groundwater monitoring in 2015 for the property at Ramona, Kansas, on which a grain storage facility was formerly operated by the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA). The monitoring was implemented on behalf of the CCC/USDA by Argonne National Laboratory and was conducted as specified in the Long-Term Groundwater Monitoring Plan (Argonne 2012) approved by the Kansas Department of Health and Environment (KDHE 2012).

  15. Exotic heavy baryons at LHC

    International Nuclear Information System (INIS)

    Biro, T.S.; Zimanyi, J.

    1993-06-01

    A heavy bottom-charm six-quark baryon is considered. A semiclassical and a Gaussian estimate show that the octet-octet bbb-ccc configuration can be favoured energetically rather than the singlet-singlet one. This result suggests that a confined bbb-ccc six-quark state may exist. Such objects may be produced in suitable amounts by heavy-ion collisions at Large Hadronic Collider energies. (R.P.) 8 refs. 1 fig

  16. DNA Polymerase κ Is a Key Cellular Factor for the Formation of Covalently Closed Circular DNA of Hepatitis B Virus.

    Directory of Open Access Journals (Sweden)

    Yonghe Qi

    2016-10-01

    Full Text Available Hepatitis B virus (HBV infection of hepatocytes begins by binding to its cellular receptor sodium taurocholate cotransporting polypeptide (NTCP, followed by the internalization of viral nucleocapsid into the cytoplasm. The viral relaxed circular (rc DNA genome in nucleocapsid is transported into the nucleus and converted into covalently closed circular (ccc DNA to serve as a viral persistence reservoir that is refractory to current antiviral therapies. Host DNA repair enzymes have been speculated to catalyze the conversion of rcDNA to cccDNA, however, the DNA polymerase(s that fills the gap in the plus strand of rcDNA remains to be determined. Here we conducted targeted genetic screening in combination with chemical inhibition to identify the cellular DNA polymerase(s responsible for cccDNA formation, and exploited recombinant HBV with capsid coding deficiency which infects HepG2-NTCP cells with similar efficiency of wild-type HBV to assure cccDNA synthesis is exclusively from de novo HBV infection. We found that DNA polymerase κ (POLK, a Y-family DNA polymerase with maximum activity in non-dividing cells, substantially contributes to cccDNA formation during de novo HBV infection. Depleting gene expression of POLK in HepG2-NTCP cells by either siRNA knockdown or CRISPR/Cas9 knockout inhibited the conversion of rcDNA into cccDNA, while the diminished cccDNA formation in, and hence the viral infection of, the knockout cells could be effectively rescued by ectopic expression of POLK. These studies revealed that POLK is a crucial host factor required for cccDNA formation during a de novo HBV infection and suggest that POLK may be a potential target for developing antivirals against HBV.

  17. On-line coupling of counter-current chromatography and macroporous resin chromatography for continuous isolation of arctiin from the fruit of Arctium lappa L.

    Science.gov (United States)

    Guo, Mengzhe; Liang, Junling; Wu, Shihua

    2010-08-13

    In this work, we have developed a novel hybrid two-dimensional counter-current chromatography and liquid chromatography (2D CCC x LC) system for the continuous purification of arctiin from crude extract of Arctium lappa. The first dimensional CCC column has been designed to fractionalize crude complex extract into pure arctiin effluent using a one-component organic/salt-containing system, and the second dimensional LC column has been packed with macroporous resin for on-line adsorption, desalination and desorption of arctiin which was effluent purified from the first CCC dimension. Thus, the crude arctiin mixture has been purified efficiently and conveniently by on-line CCC x LC in spite of the use of a salt-containing solvent system in CCC separation. As a result, high purity (more than 97%) of arctiin has been isolated by repeated injections both using the ethyl acetate-8% sodium chloride aqueous solution and butanol-1% sodium chloride aqueous solution. By contrast with the traditional CCC processes using multi-component organic/aqueous solvent systems, the present on-line CCC x LC process only used a one-component organic solvent and thus the solvent is easier to recover and regenerate. All of used solvents such as ethyl acetate, n-butanol and NaCl aqueous solution are low toxicity and environment-friendly. Moreover, the lower phase of salt-containing aqueous solution used as mobile phase, only contained minor organic solvent, which will save much organic solvent in continuous separation. In summary, our results indicated that the on-line hybrid 2D CCC x LC system using one-component organic/salt-containing aqueous solution is very promising and powerful tool for high-throughput purification of arctiin from fruits of A. lappa. 2010 Elsevier B.V. All rights reserved.

  18. Clear cell carcinoma of the ovary: Is there a role of histology-specific treatment?

    Directory of Open Access Journals (Sweden)

    Takano Masashi

    2012-06-01

    Full Text Available Abstract Several clinical trials to establish standard treatment modality for ovarian cancers included a high abundance of patients with serous histologic tumors, which were quite sensitive to platinum-based chemotherapy. On the other hand, ovarian tumor with rare histologic subtypes such as clear cell or mucinous tumors have been recognized to show chemo-resistant phenotype, leading to poorer prognosis. Especially, clear cell carcinoma of the ovary (CCC is a distinctive tumor, deriving from endometriosis or clear cell adenofibroma, and response rate to platinum-based therapy is extremely low. It was implied that complete surgical staging enabled us to distinguish a high risk group of recurrence in CCC patients whose disease was confined to the ovary (pT1M0; however, complete surgical staging procedures could not lead to improved survival. Moreover, the status of peritoneal cytology was recognized as an independent prognostic factor in early-staged CCC patients, even after complete surgical staging. In advanced cases with CCC, the patients with no residual tumor had significantly better survival than those with the tumor less than 1 cm or those with tumor diameter more than 1 cm. Therefore, the importance of achieving no macroscopic residual disease at primary surgery is so important compared with other histologic subtypes. On the other hand, many studies have shown that conventional platinum-based chemotherapy regimens yielded a poorer prognosis in patients with CCC than in patients with serous subtypes. The response rate by paclitaxel plus carboplatin (TC was slightly higher, ranging from 22% to 56%, which was not satisfactory enough. Another regimen for CCC tumors is now being explored: irinotecan plus cisplatin, and molecular targeting agents. In this review article, we discuss the surgical issues for early-staged and advanced CCC including possibility of fertility-sparing surgery, and the chemotherapy for CCC disease.

  19. Convergent close-coupling method: a `complete scattering theory`?

    Energy Technology Data Exchange (ETDEWEB)

    Bray, I; Fursa, D V

    1995-09-01

    It is demonstrated that a single convergent close-coupling (CCC) calculation of 100 eV electron impact on the ground state of helium is able to provide accurate elastic and inelastic (n {<=} 3 levels) differential cross sections, as well as singly-, doubly-, and triply-, differential ionization cross sections. Hence, it is suggested that the CCC theory deserve the title of a `complete scattering theory`. 28 refs., 5 figs.

  20. Milestones: a rapid assessment method for the Clinical Competency Committee

    OpenAIRE

    Nabors, Christopher; Forman, Leanne; Peterson, Stephen J.; Gennarelli, Melissa; Aronow, Wilbert S.; DeLorenzo, Lawrence; Chandy, Dipak; Ahn, Chul; Sule, Sachin; Stallings, Gary W.; Khera, Sahil; Palaniswamy, Chandrasekar; Frishman, William H.

    2016-01-01

    Introduction Educational milestones are now used to assess the developmental progress of all U.S. graduate medical residents during training. Twice annually, each program?s Clinical Competency Committee (CCC) makes these determinations and reports its findings to the Accreditation Council for Graduate Medical Education (ACGME). The ideal way to conduct the CCC is not known. After finding that deliberations reliant upon the new milestones were time intensive, our internal medicine residency pr...

  1. Selective decrease of components of the creatine kinase system and ATP synthase complex in chronic Chagas disease cardiomyopathy.

    Directory of Open Access Journals (Sweden)

    Priscila Camillo Teixeira

    2011-06-01

    Full Text Available BACKGROUND: Chronic Chagas disease cardiomyopathy (CCC is an inflammatory dilated cardiomyopathy with a worse prognosis than other cardiomyopathies. CCC occurs in 30 % of individuals infected with Trypanosoma cruzi, endemic in Latin America. Heart failure is associated with impaired energy metabolism, which may be correlated to contractile dysfunction. We thus analyzed the myocardial gene and protein expression, as well as activity, of key mitochondrial enzymes related to ATP production, in myocardial samples of end-stage CCC, idiopathic dilated (IDC and ischemic (IC cardiomyopathies. METHODOLOGY/PRINCIPAL FINDINGS: Myocardium homogenates from CCC (N=5, IC (N=5 and IDC (N=5 patients, as well as from heart donors (N=5 were analyzed for protein and mRNA expression of mitochondrial creatine kinase (CKMit and muscular creatine kinase (CKM and ATP synthase subunits aplha and beta by immunoblotting and by real-time RT-PCR. Total myocardial CK activity was also assessed. Protein levels of CKM and CK activity were reduced in all three cardiomyopathy groups. However, total CK activity, as well as ATP synthase alpha chain protein levels, were significantly lower in CCC samples than IC and IDC samples. CCC myocardium displayed selective reduction of protein levels and activity of enzymes crucial for maintaining cytoplasmic ATP levels. CONCLUSIONS/SIGNIFICANCE: The selective impairment of the CK system may be associated to the loss of inotropic reserve observed in CCC. Reduction of ATP synthase alpha levels is consistent with a decrease in myocardial ATP generation through oxidative phosphorylation. Together, these results suggest that the energetic deficit is more intense in the myocardium of CCC patients than in the other tested dilated cardiomyopathies.

  2. Substance use disorder and compulsory commitment to care: a care-ethical decision-making framework.

    Science.gov (United States)

    Nicolini, Marie; Vandenberghe, Joris; Gastmans, Chris

    2017-11-29

    In the era of deinstitutionalisation of psychiatric patients, steady or even increasing rates of compulsory commitment to care (CCC) are an intriguing phenomenon to analyse. From a clinical, legal and ethical perspective, CCC continues to be a controversial practice in psychiatry, and perhaps even more so when applied to patients with severe substance use disorder (SUD). Several reasons make it controversial. The lack of consensus about the benefits of CCC and professional disagreement about what mental illness and autonomy mean in the case of SUD make it difficult to apply ethically sound clinical decision-making in CCC. Also, the medico-legal framework underlying CCC use sometimes appears to foster the use of reductionist clinical evaluation. Layered on top of these issues is how stakeholders view coercion. There is a discrepancy between clinicians' and patients' perception of coercion, which leads to clinician-patient differences on whether CCC is necessary. Moreover, the way in which the evaluation is typically carried out influences patients' perception of coercion and subsequently their motivation for participating fully in treatment. In this article, we explore the value of care ethics, often applied to care practices such as nursing, when applied to more procedural medical practices, such as decision-making regarding CCC. The care-ethical approach views decision-making as part of a dynamic care process, within which the lived experience, interpretative dialogue and promotion of dignity are core features. Embracing this new framework means a paradigm shift in when the therapeutic relationship begins, namely, investing in it occurs while conducting an evaluation for a possible CCC procedure. Unlike in current typical evaluations, early cultivation of the therapeutic relationship enables the patient to participate in the definition of his needs, reduces perceived coercion and negative emotions and enhances treatment motivation. Finally, implications of this

  3. Cancer Care Coordinators to Improve Tamoxifen Persistence in Breast Cancer: How Heterogeneity in Baseline Prognosis Impacts on Cost-Effectiveness.

    Science.gov (United States)

    Nair, Nisha; Kvizhinadze, Giorgi; Blakely, Tony

    2016-12-01

    To assess the cost-effectiveness of a cancer care coordinator (CCC) in helping women with estrogen receptor positive (ER+) early breast cancer persist with tamoxifen for 5 years. We investigated the cost-effectiveness of a CCC across eight breast cancer subtypes, defined by progesterone receptor (PR) status, human epidermal growth factor receptor 2 (HER2) status, and local/regional spread. These subtypes range from excellent to poorer prognoses. The CCC helped in improving tamoxifen persistence by providing information, checking-in by phone, and "troubleshooting" concerns. We constructed a Markov macrosimulation model to estimate health gain (in quality-adjusted life-years or QALYs) and health system costs in New Zealand, compared with no CCC. Participants were modeled until death or till the age of 110 years. Some input parameters (e.g., the impact of a CCC on tamoxifen persistence) had sparse evidence. Therefore, we used estimates with generous uncertainty and conducted sensitivity analyses. The cost-effectiveness of a CCC for regional ER+/PR-/HER2+ breast cancer (worst prognosis) was NZ $23,400 (US $15,800) per QALY gained, compared with NZ $368,500 (US $248,800) for local ER+/PR+/HER2- breast cancer (best prognosis). Using a cost-effectiveness threshold of NZ $45,000 (US $30,400) per QALY, a CCC would be cost-effective only in the four subtypes with the worst prognoses. There is value in investigating cost-effectiveness by different subtypes within a disease. In this example of breast cancer, the poorer the prognosis, the greater the health gains from a CCC and the better the cost-effectiveness. Incorporating heterogeneity in a cost-utility analysis is important and can inform resource allocation decisions. It is also feasible to undertake in practice. Copyright © 2016 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  4. Good news and bad news: depressive symptoms decline and undertreatment increases with age in home care and institutional settings.

    Science.gov (United States)

    Szczerbińska, Katarzyna; Hirdes, John P; Zyczkowska, Jolanta

    2012-12-01

    Examination of prevalence of depressive symptoms among older persons in home care (HC) and complex continuing care (CCC) hospitals/units, factors associated with depressive symptoms in those settings, and rate of antidepressant use among older persons with depressive symptoms. Observational study using data from interRAI assessments used in normal clinical practice. Logistic regression models were used to identify factors associated with depressive symptoms in the frail elderly and treatment approaches were described. Fourteen HC agencies and 134 CCC hospitals/units in Ontario, Canada. Older persons (N = 191,9871) aged 65 years and older, including 114,497 persons from HC and 77,490 persons from CCC. Data were collected using Resident Assessment Instrument 2.0 (RAI 2.0) (1996-2004) in CCC and Resident Assessment Instrument for Home Care (RAI-HC) (2003-2004) in HC. Prevalence of depressive symptoms among older HC enrollees was lower (12.0%) than in CCC (23.6%). It decreased significantly with age in HC (to about 6% in those older than 95 years) but there were not substantial age differences in CCC. Common factors associated with depressive symptoms in both types of care were cognitive impairment, instability of health, daily pain, disability in activities of daily living; however, advanced age lost its protective effect in CCC. Less than half of the persons in HC and CCC with depressive symptoms were treated with antidepressants and their use decreased with age. Undertreatment of depressive symptoms among older persons remains a serious problem. Learning more about factors associated with depressive symptoms among the oldest old might improve detection and treatment of depression.

  5. Annual Report of Monitoring at Barnes, Kansas, in 2016

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-05-01

    In 2006, the CCC/USDA assumed responsibility for the site investigation relating to potential carbon tetrachloride contamination. Initially, the CCC/USDA developed and implemented a work plan for targeted groundwater sampling and monitoring well installation (KDHE 2009). The investigation and subsequent monitoring (Argonne 2008a-d, 2009a,b, 2010, 2011, 2012, 2013, 2015a,b, 2016) were performed by the Environmental Science Division of Argonne National Laboratory. The reports of environmental investigations at Barnes are summarized.

  6. Stock Markets Volatility Spillovers during Financial Crises : A DCC-MGARCH with Skew-t Approach

    OpenAIRE

    Bala, Dahiru A.; Takimoto, Taro

    2016-01-01

    We investigate stock markets volatility spillovers in selected emerging and major developed markets using multivariate GARCH (MGARCH) models [namely; DVECH, CCC-MGARCH, CCC-VARMA-(A)MGARCH, VAR-EGARCH, BEKK-(A)MGARCH, DCC-MGARCH (with Gaussian and t distributions) and DCC-with-skew-t density]. The paper analyses the impacts of recent global financial crisis (2007{2009) on stock market volatility and examines their dynamic interactions using several MGARCH model variants. Structural break dete...

  7. Field Testing of Cryogenic Carbon Capture

    Energy Technology Data Exchange (ETDEWEB)

    Sayre, Aaron [Sustainable Energy Solutions, LLC; Frankman, Dave [Sustainable Energy Solutions, LLC; Baxter, Andrew [Sustainable Energy Solutions, LLC; Stitt, Kyler [Sustainable Energy Solutions, LLC; Baxter, Larry [Sustainable Energy Solutions, LLC; Brigham Young Univ., Provo, UT (United States)

    2017-07-17

    Sustainable Energy Solutions has been developing Cryogenic Carbon Capture™ (CCC) since 2008. In that time two processes have been developed, the External Cooling Loop and Compressed Flue Gas Cryogenic Carbon Capture processes (CCC ECL™ and CCC CFG™ respectively). The CCC ECL™ process has been scaled up to a 1TPD CO2 system. In this process the flue gas is cooled by an external refrigerant loop. SES has tested CCC ECL™ on real flue gas slip streams from subbituminous coal, bituminous coal, biomass, natural gas, shredded tires, and municipal waste fuels at field sites that include utility power stations, heating plants, cement kilns, and pilot-scale research reactors. The CO2 concentrations from these tests ranged from 5 to 22% on a dry basis. CO2 capture ranged from 95-99+% during these tests. Several other condensable species were also captured including NO2, SO2 and PMxx at 95+%. NO was also captured at a modest rate. The CCC CFG™ process has been scaled up to a .25 ton per day system. This system has been tested on real flue gas streams including subbituminous coal, bituminous coal and natural gas at field sites that include utility power stations, heating plants, and pilot-scale research reactors. CO2 concentrations for these tests ranged from 5 to 15% on a dry basis. CO2 capture ranged from 95-99+% during these tests. Several other condensable species were also captured including NO2, SO2 and PMxx at 95+%. NO was also captured at 90+%. Hg capture was also verified and the resulting effluent from CCC CFG™ was below a 1ppt concentration. This paper will focus on discussion of the capabilities of CCC, the results of field testing and the future steps surrounding the development of this technology.

  8. Purification of drugs from biological fluids by counter-current chromatography.

    Science.gov (United States)

    Hochlowski, Jill E; Pan, Jeffrey Y; Searle, Philip A; Buck, Wayne R; Spanton, Stephen G

    2009-08-21

    Experiments were performed to demonstrate the potential of counter-current chromatography (CCC) for the isolation of drugs and their metabolites from biological matrices relevant to the metabolism studies of pharmaceutical research. Examples of typical drugs are spiked into biological media ex vivo to provide test samples for analysis. A mass spectrometer hyphenated to a CCC allows for the detection of small molecule drugs within the matrix through selected ion monitoring, and fraction collection can provide material for further structural elucidation by NMR.

  9. African Journal of Biotechnology Vol

    African Journals Online (AJOL)

    Gaga E Tonukari

    List of the random primers used, their nucleotide sequence and annealing temperatures. Primers. Sequence 5`- 3`. Annealing. Temperature. °C/time (s). 1. ATG ACG TTG A. 2. GGG CTA GGG T. 3. ACC GGG AAC G. 4. AGC AGG TGG A. 45/30. 5. AGG CCC CTG T. 6. ATG CCC CTG T. 7. AAA GCT GCG G. 8. ACC GCC GAA ...

  10. Star formation induced by cloud-cloud collisions and galactic giant molecular cloud evolution

    Science.gov (United States)

    Kobayashi, Masato I. N.; Kobayashi, Hiroshi; Inutsuka, Shu-ichiro; Fukui, Yasuo

    2018-05-01

    Recent millimeter/submillimeter observations towards nearby galaxies have started to map the whole disk and to identify giant molecular clouds (GMCs) even in the regions between galactic spiral structures. Observed variations of GMC mass functions in different galactic environments indicates that massive GMCs preferentially reside along galactic spiral structures whereas inter-arm regions have many small GMCs. Based on the phase transition dynamics from magnetized warm neutral medium to molecular clouds, Kobayashi et al. (2017, ApJ, 836, 175) proposes a semi-analytical evolutionary description for GMC mass functions including a cloud-cloud collision (CCC) process. Their results show that CCC is less dominant in shaping the mass function of GMCs than the accretion of dense H I gas driven by the propagation of supersonic shock waves. However, their formulation does not take into account the possible enhancement of star formation by CCC. Millimeter/submillimeter observations within the Milky Way indicate the importance of CCC in the formation of star clusters and massive stars. In this article, we reformulate the time-evolution equation largely modified from Kobayashi et al. (2017, ApJ, 836, 175) so that we additionally compute star formation subsequently taking place in CCC clouds. Our results suggest that, although CCC events between smaller clouds are more frequent than the ones between massive GMCs, CCC-driven star formation is mostly driven by massive GMCs ≳ 10^{5.5} M_{⊙} (where M⊙ is the solar mass). The resultant cumulative CCC-driven star formation may amount to a few 10 percent of the total star formation in the Milky Way and nearby galaxies.

  11. The skeletal developmental toxicity of chlormequat chloride and its underlying mechanisms

    International Nuclear Information System (INIS)

    Huang, Dan; Wu, Shuang; Hou, Xiaohong; Jia, Lixia; Meng, Qinghe; Chu, Hongqian; Jiang, Jianjun; Shang, Lanqin; Hao, Weidong

    2017-01-01

    Chlormequat Chloride (CCC), a widely used plant growth regulator, could decrease body weight in animals; however, the mechanism has not been well studied. This study was designed to evaluate the skeletal development toxicity of CCC on pubertal male Sprague-Dawley (SD) rats and to investigate whether CCC impacts the development of chondrocyte, osteoblast and osteoclast through growth hormone (GH) and insulin like growth factor 1 (IGF-I). Rats from 23 to 70 on postnatal days were exposed to CCC daily by gavage at doses of 0, 75, 150, and 300 mg/kg bw/d. The results showed that the size of femurs and tibias, bone mineral density and biomechanical parameters were significantly decreased in the 300 mg/kg bw/d group compared with the control group. The concentration of osteocalcin (OCN) and C-terminal telopeptide of type I collagen (CTX-I) in blood in the 150 mg/kg bw/d group was also changed. The mRNA expression ratio of the receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) in 150 and 300 mg/kg bw/d group was increased. Histological analysis of proximal and distal epiphyseal plates of the right femurs showed that both the proliferative zone and hypertrophic zone narrowed in CCC-treated groups. The concentration of IGF-I in blood was reduced with an increase in exposure doses of CCC. The mRNA expression of growth hormone receptor (GHR) in tibia was decreased in the CCC-treated group. The results indicated that CCC might indirectly impact the formation and activation of chondrocytes, osteoblasts and osteoclasts because of the decline of GHR and IGF-I, leading to skeletal development damage.

  12. The performance of low-cost commercial cloud computing as an alternative in computational chemistry.

    Science.gov (United States)

    Thackston, Russell; Fortenberry, Ryan C

    2015-05-05

    The growth of commercial cloud computing (CCC) as a viable means of computational infrastructure is largely unexplored for the purposes of quantum chemistry. In this work, the PSI4 suite of computational chemistry programs is installed on five different types of Amazon World Services CCC platforms. The performance for a set of electronically excited state single-point energies is compared between these CCC platforms and typical, "in-house" physical machines. Further considerations are made for the number of cores or virtual CPUs (vCPUs, for the CCC platforms), but no considerations are made for full parallelization of the program (even though parallelization of the BLAS library is implemented), complete high-performance computing cluster utilization, or steal time. Even with this most pessimistic view of the computations, CCC resources are shown to be more cost effective for significant numbers of typical quantum chemistry computations. Large numbers of large computations are still best utilized by more traditional means, but smaller-scale research may be more effectively undertaken through CCC services. © 2015 Wiley Periodicals, Inc.

  13. Use of Key Performance Indicators to Improve Milestone Assessment in Semi-Annual Clinical Competency Committee Meetings.

    Science.gov (United States)

    Chen, Fei; Arora, Harendra; Martinelli, Susan M

    2017-01-01

    The Accreditation Council for Graduate Medical Education's Next Accreditation System requires residency programs to semiannually submit composite milestone data on each resident's performance. This report describes and evaluates a new assessment review procedure piloted in our departmental Clinical Competency Committee (CCC) semi-annual meeting in June 2016. A modified Delphi technique was utilized to develop key performance indicators (KPI) linking milestone descriptors to clinical practice. In addition, the CCC identified six specific milestone sub-competencies that would be prescored with objective data prior to the meeting. Each resident was independently placed on the milestones by 3 different CCC faculty members. Milestone placement data of the same cohort of 42 residents (Clinical Anesthesia Years 1-3) were collected to calculate inter-rater reliability of the assessment procedures before and after the implemented changes. A survey was administrated to collect CCC feedback on the new procedure. The procedure assisted in reducing meeting time from 8 to 3.5 hours. Survey of the CCC members revealed positive perception of the procedure. Higher inter-rater reliability of the milestone placement was obtained using the implemented KPIs (Intraclass correlation coefficient [ICC] single measure range: before=.53-.94, after=.74-.98). We found the new assessment procedure beneficial to the efficiency and transparency of the assessment process. Further improvement of the procedure involves refinement of KPIs and additional faculty development on KPIs to allow non-CCC faculty to provide more accurate resident evaluations.

  14. Resident dashboards: helping your clinical competency committee visualize trainees’ key performance indicators

    Directory of Open Access Journals (Sweden)

    Karen A. Friedman

    2016-03-01

    Full Text Available Introduction: Under the Next Accreditation System, programs need to find ways to collect and assess meaningful reportable information on its residents to assist the program director regarding resident milestone progression. This paper discusses the process that one large Internal Medicine Residency Program used to provide both quantitative and qualitative data to its clinical competency committee (CCC through the creation of a resident dashboard. Methods: Program leadership at a large university-based program developed four new end of rotation evaluations based on the American Board of Internal Medicine (ABIM and Accreditation Council of Graduated Medical Education's (ACGME 22 reportable milestones. A resident dashboard was then created to pull together both milestone- and non-milestone-based quantitative data and qualitative data compiled from faculty, nurses, peers, staff, and patients. Results: Dashboards were distributed to the members of the CCC in preparation for the semiannual CCC meeting. CCC members adjudicated quantitative and qualitative data to present their cohort of residents at the CCC meeting. Based on the committee's response, evaluation scores remained the same or were adjusted. Final milestone scores were then entered into the accreditation data system (ADS on the ACGME website. Conclusions: The process of resident assessment is complex and should comprise both quantitative and qualitative data. The dashboard is a valuable tool for program leadership to use both when evaluating house staff on a semiannual basis at the CCC and to the resident in person.

  15. Resident dashboards: helping your clinical competency committee visualize trainees' key performance indicators.

    Science.gov (United States)

    Friedman, Karen A; Raimo, John; Spielmann, Kelly; Chaudhry, Saima

    2016-01-01

    Under the Next Accreditation System, programs need to find ways to collect and assess meaningful reportable information on its residents to assist the program director regarding resident milestone progression. This paper discusses the process that one large Internal Medicine Residency Program used to provide both quantitative and qualitative data to its clinical competency committee (CCC) through the creation of a resident dashboard. Program leadership at a large university-based program developed four new end of rotation evaluations based on the American Board of Internal Medicine (ABIM) and Accreditation Council of Graduated Medical Education's (ACGME) 22 reportable milestones. A resident dashboard was then created to pull together both milestone- and non-milestone-based quantitative data and qualitative data compiled from faculty, nurses, peers, staff, and patients. Dashboards were distributed to the members of the CCC in preparation for the semiannual CCC meeting. CCC members adjudicated quantitative and qualitative data to present their cohort of residents at the CCC meeting. Based on the committee's response, evaluation scores remained the same or were adjusted. Final milestone scores were then entered into the accreditation data system (ADS) on the ACGME website. The process of resident assessment is complex and should comprise both quantitative and qualitative data. The dashboard is a valuable tool for program leadership to use both when evaluating house staff on a semiannual basis at the CCC and to the resident in person.

  16. Final work plan : investigation of potential contamination at the former USDA facility in Powhattan, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2007-02-02

    This Work Plan outlines the scope of work to be conducted to investigate the subsurface contaminant conditions at the property formerly leased by the Commodity Credit Corporation (CCC) in Powhattan, Kansas (Figure 1.1). Data obtained during this event will be used to (1) evaluate potential contaminant source areas on the property; (2) determine the vertical and horizontal extent of potential contamination; and (3) provide recommendations for future action, with the ultimate goal of assigning this site No Further Action status. The planned investigation includes groundwater monitoring requested by the Kansas Department of Health and Environment (KDHE), in accordance with Section V of the Intergovernmental Agreement between the KDHE and the Farm Service Agency of the U.S. Department of Agriculture (USDA). The work is being performed on behalf of the CCC/USDA by the Environmental Science Division of Argonne National Laboratory. A nonprofit, multidisciplinary research center operated by the University of Chicago for the U.S. Department of Energy, Argonne provides technical assistance to the CCC/USDA with environmental site characterization and remediation at former CCC/USDA grain storage facilities. Argonne issued a Master Work Plan (Argonne 2002) that has been approved by the KDHE. The Master Work Plan describes the general scope of all investigations at former CCC/USDA facilities in Kansas and provides guidance for these investigations. It should be consulted for the complete details of plans for work associated with the former CCC/USDA facility at Powhattan.

  17. Revisiting resolution in hydrodynamic countercurrent chromatography: tubing bore effect.

    Science.gov (United States)

    Berthod, A; Faure, K

    2015-04-17

    A major challenge in countercurrent chromatography (CCC), the technique that works with a support-free biphasic liquid system, is to retain the liquid stationary phase inside the CCC column (Sf parameter). Two solutions are commercially available: the hydrostatic CCC columns, also called centrifugal partition chromatographs (CPC), with disks of interconnected channels and rotary seals, and the hydrodynamic CCC columns with bobbins of coiled open tube and no rotary seals. It was demonstrated that the amount of liquid stationary phase retained by a coiled tube was higher with larger bore tubing than with small bore tubes. At constant column volume, small bore tubing will be longer producing more efficiency than larger bore tube that will better retain the liquid stationary phase. Since the resolution equation in CCC is depending on both column efficiency and stationary phase retention ratio, the influence of the tubing bore should be studied. This theoretical work showed that there is an optimum tubing bore size depending on solute partition coefficient and mobile phase flow rate. The interesting result of the theoretical study is that larger tubing bores allow for dramatically reduced experiment durations for all solutes: in reversed phase CCC (polar mobile phase), hydrophobic solutes are usually highly retained. These apolar solutes can be separated by the same coil at high flow rates and reduced Sf with similar retention times as polar solutes separated at smaller flow rates and much higher Sf. Copyright © 2015 Elsevier B.V. All rights reserved.

  18. Schinus terebinthifolius countercurrent chromatography (Part II): Intra-apparatus scale-up and inter-apparatus method transfer.

    Science.gov (United States)

    Costa, Fernanda das Neves; Vieira, Mariana Neves; Garrard, Ian; Hewitson, Peter; Jerz, Gerold; Leitão, Gilda Guimarães; Ignatova, Svetlana

    2016-09-30

    Countercurrent chromatography (CCC) is being widely used across the world for purification of various materials, especially in natural product research. The predictability of CCC scale-up has been successfully demonstrated using specially designed instruments of the same manufacturer. The reality is that the most of CCC users do not have access to such instruments and do not have enough experience to transfer methods from one CCC column to another. This unique study of three international teams is based on innovative approach to simplify the scale-up between different CCC machines using fractionation of Schinus terebinthifolius berries dichloromethane extract as a case study. The optimized separation methodology, recently developed by the authors (Part I), was repeatedly performed on CCC columns of different design available at most research laboratories across the world. Hexane - ethyl acetate - methanol - water (6:1:6:1, v/v/v/v) was used as solvent system with masticadienonic and 3β-masticadienolic acids as target compounds to monitor stationary phase retention and calculate peak resolution. It has been demonstrated that volumetric, linear and length scale-up transfer factors based on column characteristics can be directly applied to different i.d., volume and length columns independently on instrument make in an intra-apparatus scale-up and inter-apparatus method transfer. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. Antimicrobial assay and genetic screening of selected freshwater Cyanobacteria and identification of a biomolecule dihydro-2H-pyran-2-one derivative.

    Science.gov (United States)

    Srivastava, A; Singh, V K; Patnaik, S; Tripathi, J; Singh, P; Nath, G; Asthana, R K

    2017-04-01

    Explorations of freshwater Cyanobacteria as antimicrobial (bacteria, fungi and methicillin-resistant Staphylococcus aureus (MRSA) strains) drug resource using bioassay, NRPS (non-ribosomal polypeptide synthetase) and PKS (polyketide synthase) genes, as well as in silico approach. We have bioassayed the extracts of Phormidium CCC727, Geitlerinema CCC728, Arthrospira CCC729, Leptolyngbya CCC732, Phormidium CCC730, Phormidium CCC731 against six pathogenic bacteria comprising Gram (+ve): S. aureus including seven clinical MRSA and Enterococcus faecalis, Gram (-ve): Escherichia coli, Salmonella Typhimurium, Klebsiella pneumoniae and Shigella boydii along with non-pathogenic Enterobacter aerogenes as well as fungal strains (Cryptococcus neoformans and Candida albicans, C. krusei, C. tropicalis and Aspergillus niger) exhibiting antimicrobial potential. The NRPS and PKS genes of the target strains were also amplified and sequenced. The putative protein structures were predicted using bioinformatics approach. PKS gene expression indicated β keto-acyl synthase as one of the important active domains in the biomolecules related to antitumour and antifungal group. The simultaneous identification of the biomolecule (dihydro-2H-pyran-2-one derivative) was also inferred spectroscopically. Freshwater Cyanobacteria are prolific producers of secondary metabolite(s) that may act as the antimicrobial drug resource in addition to their much explored marine counterpart. © 2016 The Society for Applied Microbiology.

  20. Use of limonene in countercurrent chromatography: a green alkane substitute.

    Science.gov (United States)

    Faure, Karine; Bouju, Elodie; Suchet, Pauline; Berthod, Alain

    2013-05-07

    Counter-current chromatography (CCC) is a preparative separation technique working with the two liquid phases of a biphasic liquid system. One phase is used as the mobile phase when the other, the stationary phase, is held in place by centrifugal fields. Limonene is a biorenewable cycloterpene solvent coming from orange peel waste. It was evaluated as a possible substitute for heptane in CCC separations. The limonene/methanol/water and heptane/methanol/water phase diagrams are very similar at room temperature. The double bonds of the limonene molecule allows for possible π-π interactions with solutes rendering limonene slightly more polar than heptane giving small differences in solute partition coefficients in the two systems. The 24% higher limonene density is a difference with heptane that has major consequences in CCC. The polar and apolar phases of the limonene/methanol/water 10/9/1 v/v have -0.025 g/cm(3) density difference (lower limonene phase) compared to +0.132 g/cm(3) with heptane (upper heptane phase). This precludes the use of this limonene system with hydrodynamic CCC columns that need significant density difference to retain a liquid stationary phase. It is an advantage with hydrostatic CCC columns because density difference is related to the working pressure drop: limonene allows one to work with high centrifugal fields and moderate pressure drop. Limonene has the capability to be a "green" alternative to petroleum-based solvents in CCC applications.

  1. Coronary collateral circulation in patients with chronic coronary total occlusion; its relationship with cardiac risk markers and SYNTAX score.

    Science.gov (United States)

    Börekçi, A; Gür, M; Şeker, T; Baykan, A O; Özaltun, B; Karakoyun, S; Karakurt, A; Türkoğlu, C; Makça, I; Çaylı, M

    2015-09-01

    Compared to patients without a collateral supply, long-term cardiac mortality is reduced in patients with well-developed coronary collateral circulation (CCC). Cardiovascular risk markers, such as N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitive C-reactive protein (hs-CRP) and high-sensitive cardiac troponin T (hs-cTnT) are independent predictors for cardiovascular mortality. The main goal of this study was to examine the relationship between CCC and cardiovascular risk markers. We prospectively enrolled 427 stable coronary artery disease patients with chronic total occlusion (mean age: 57.5±11.1 years). The patients were divided into two groups, according to their Rentrop scores: (a) poorly developed CCC group (Rentrop 0 and 1) and (b) well-developed CCC group (Rentrop 2 and 3). NT-proBNP, hs-CRP, hs-cTnT, uric acid and other biochemical markers were also measured. The SYNTAX score was calculated for all patients. The patients in the poorly developed CCC group had higher frequencies of diabetes and hypertension (prisk markers, such as NT-proBNP, hs-cTnT and hs-CRP are independently associated with CCC in stable coronary artery disease with chronic total occlusion. © The Author(s) 2014.

  2. Kefir Mikroflorası Üzerinde Araştırma

    OpenAIRE

    Erol Ergüllü; Mustafa Üçüncü

    2015-01-01

    Çalışmada, çeşitli yörelerden sağlanmış 7 kefir örneğinin mikroflorası araştırılmış ve elde edilen bulgulara göre, kefir mikroflorasında süt asidi bakterileri (Streptokok ve Laktobasiller) ile mayaların çoğunlukta olduğu belirlenmiştir. Bu bakteri türlerinden her birinin kefir oluşumunda ayrı bir yeri bulunmaktadır. Süt asidi bakterileri sütü pıhtılaştırmakta ve bunlardan bazıları da ayrıca uçucu asitler oluşturarak, kefirin tat ve kokusunun meydana gelmesine katkıda bulunmaktadırlar. Mayalar...

  3. UTILIZATION OF COAL FLY ASH AS LOW-COST ADSORBENT MATERIAL FOR NICKEL REMOVAL APPLICATIONS

    OpenAIRE

    KILIÇ, Murat; ÇEPELİOĞULLAR, Özge; KIRBIYIK, Çisem; PÜTÜN, Ayşe Eren; PÜTÜN, Ersan

    2015-01-01

    Bu çalışmada, kömür uçucu külü sulu çözeltilerden nikel(II) iyonlarının gideriminde düşük maliyetli adsorban olarak değerlendirilmiştir. pH, adsorban miktarı, temas süresi ve başlangıç ağır metal derişimi gibi adsorpsiyon işlemini etkileyen deneysel parametrelerin optimizasyonu gerçekleştirilmiştir. Elde edilen deneysel veriler Langmuir, Freundlich ve Dubinin-Radushkevich (D-R) izotermleri kullanılarak modellenmiştir. Langmuir modelinin adsorpsiyon verilerine daha iyi uyduğu belirlenmiştir. U...

  4. On the possibility of cyclic postvariscan exogene ore formation

    International Nuclear Information System (INIS)

    Schmid, H.

    1980-01-01

    The appearance of time-bound or time-related ore deposits is well known. As for the variscan-orogen-area, the author tries to explain the formation of time-related deposits of U-Cu in the Permian, Pb, Zn(Ba,Sr) in Muschelkalk and lower Keuper, Mn in Lias and Fe in Dogger by a systematic sequence of terrigene solutions from variscan weathering-detritus according to following scheme: Firstly, in the Permian, the mobile elements U and Cu were leached. In Muschelkalk and Keuper climatic (weathering) conditions caused decomposition of silicates (particularly potassium-feldspars), so that Pb, Ba, Sr and Zn became free. Then in special acid leaching conditions, Mn and Fe could be transported. This system allows to suppose exogene origin for some deposits for which in literature endogene-sedimentary formation is considered. (orig.) [de

  5. Kefir Mikroflorası Üzerinde Araştırma

    OpenAIRE

    Ergüllü, Erol; Üçüncü, Mustafa

    2014-01-01

      Çalışmada, çeşitli yörelerden sağlanmış 7 kefir örneğinin mikroflorası araştırılmış ve elde edilen bulgulara göre, kefir mikroflorasında süt asidi bakterileri (Streptokok ve Laktobasiller) ile mayaların çoğunlukta olduğu belirlenmiştir. Bu bakteri türlerinden her birinin kefir oluşumunda ayrı bir yeri bulunmaktadır. Süt asidi bakterileri sütü pıhtılaştırmakta ve bunlardan bazıları da ayrıca uçucu asitler oluşturarak, kefirin tat ve kokusunun meydana gelmesine katkıda bulunmaktadırlar. Mayal...

  6. Kefir Mikroflorası Üzerinde Araştırma

    OpenAIRE

    Ergüllü, Erol; Üçüncü, Mustafa

    2015-01-01

      Çalışmada, çeşitli yörelerden sağlanmış 7 kefir örneğinin mikroflorası araştırılmış ve elde edilen bulgulara göre, kefir mikroflorasında süt asidi bakterileri (Streptokok ve Laktobasiller) ile mayaların çoğunlukta olduğu belirlenmiştir. Bu bakteri türlerinden her birinin kefir oluşumunda ayrı bir yeri bulunmaktadır. Süt asidi bakterileri sütü pıhtılaştırmakta ve bunlardan bazıları da ayrıca uçucu asitler oluşturarak, kefirin tat ve kokusunun meydana gelmesine katkıda bulunmaktadırlar. Mayal...

  7. Contribution to the study of the hydrolysis of uranium carbides (1963); Contribution a l'etude de l'hydrolyse des carbures d'uranium (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Spitz, J [Commisariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1963-06-15

    The hydrolysis of uranium monocarbide in neutral or acid medium leads to the formation of a complex mixture of hydrogen and hydrocarbons mostly saturated. When UC-U alloys are dissolved in hydrochloric-phosphoric medium, the free uranium contents can be determined with good accuracy from the composition of the gaseous phase. The hydrolysis of mixtures of uranium mono - and dicarbide in neutral or acid medium, leads to the formation of a complex mixture of hydrogen and gaseous and condensed hydrocarbons, the composition of which is principally dependent upon the UC{sub 2} content. The reaction mechanisms which are presented in this paper for the hydrolysis of UC and UC{sub 2} provide account for all experimental observations. (author) [French] L'hydrolyse en milieu neutre ou acide du monocarbure d'uranium conduit a la formation d'un melange complexe d'hydrogene et d'hydrocarbures, satures en grande majorite. L'attaque en milieu chlorhydrique-phosphorique des alliages UC-U permet la determination avec une bonne precision, des teneurs en uranium libre a partir de la composition des gaz degages. L'hydrolyse en milieu neutre ou acide des melanges de mono - et dicarbure d'uranium conduit a la formation d'un melange complexe d'hydrogene et d'hydrocarbures gazeux et condenses, dont la composition est essentiellement fonction de la teneur en UC{sub 2}. Les mecanismes reactionnels proposes pour l'hydrolyse de UC et UC{sub 2} rendent compte de tous les faits experimentaux observes. (auteur)

  8. Design & fabrication of two seated aircraft with an advanced rotating leading edge wing

    Science.gov (United States)

    Al Ahmari, Saeed Abdullah Saeed

    The title of this thesis is "Design & Fabrication of two Seated Aircraft with an Advanced Rotating Leading Edge Wing", this gives almost a good description of the work has been done. In this research, the moving surface boundary-layer control (MSBC) concept was investigated and implemented. An experimental model was constructed and tested in wind tunnel to determine the aerodynamic characteristics using the leading edge moving surface of modified semi-symmetric airfoil NACA1214. The moving surface is provided by a high speed rotating cylinder, which replaces the leading edge of the airfoil. The angle of attack, the cylinder surfaces velocity ratio Uc/U, and the flap deflection angle effects on the lift and drag coefficients and the stall angle of attack were investigated. This new technology was applied to a 2-seat light-sport aircraft that is designed and built in the Aerospace Engineering Department at KFUPM. The project team is led by the aerospace department chairman Dr. Ahmed Z. AL-Garni and Dr. Wael G. Abdelrahman and includes graduate and under graduate student. The wing was modified to include a rotating cylinder along the leading edge of the flap portion. This produced very promising results such as the increase of the maximum lift coefficient at Uc/U=3 by 82% when flaps up and 111% when flaps down at 40° and stall was delayed by 8degrees in both cases. The laboratory results also showed that the effective range of the leading-edge rotating cylinder is at low angles of attack which reduce the need for higher angles of attack for STOL aircraft.

  9. Synthesis and characterization of the structural and magnetic properties of new uranium and copper-based silicides and germanides: study of the physical and hydridation properties of some compounds belonging to the Gd-Ni-X systems, where X = Ga, Al, Sn

    International Nuclear Information System (INIS)

    Pechev, St.

    1998-01-01

    Three novel phases, U 3 Cu 4 Si 4 , U 3 Cu 4 Ge 4 and UCuGe 1,77 , were prepared in the U - Cu - X (X = Si or Ge) ternary system. Their structural and magnetic properties were investigated. The magnetic structures of the first two compounds were determined by neutron diffraction. Structural and magnetic behaviour transitions occur as copper substitutes silicon atoms in the UCu x Si 2-x (0,28 ≤ x ≤ 0,96) solid solution. Thus, the structure of the compositions changes in the α-ThSi 2 (tetragonal) → AlB 2 (hexagonal) → Ni 2 In(hexagonal) sequence while a transition from a nonmagnetic to ferromagnetic then antiferromagnetic behaviour is observed. The magnetic properties of the different compositions are governed by a Kondo - RKKY -type interactions competition. Crystallographic disorder and magnetic frustrations are at the origin of a spin glass state between the ferro- and antiferromagnetic areas. The investigations of the GdNi 3 X 2 (X =Ga, Al, Sn) compounds revealed that their structural and magnetic properties are strongly dependent on the nature of the X element as well as the on thermal treatment. A CaCu 5 → HoNi 2,6 Ga 2,4 - type structure transition and a ferro - to antiferromagnetic behaviour evolution are favoured by the increase of the X - atom size. A commensurate modulated crystal structure (described also as a a HoNi 2,6 Ga 2,4 x a HoNi 2,6 Ga 2,4 x 2c HoNi 2,6 Ga 2,4 -type superstructure) has been observed for GdNi 3 Al 2 . Hydrogen absorption in Gd 3 Ni 6 Al 2 and GdNi 3 Al 2 weakens the strength of the magnetic interactions. (author)

  10. WE-A-17A-08: Evaluation of the OncentraBrachy Collapsed Cone Convolution Algorithm for Ir-192 Source Using Phantom and Real-Patient Heterogeneous Geometries

    International Nuclear Information System (INIS)

    Ma, Y; Lacroix, F; Lavallee, M; Beaulieu, L

    2014-01-01

    Purpose: To evaluate the commercially released Collapsed Cone convolution-based(CCC) dose calculation module of the Elekta OncentraBrachy(OcB) treatment planning system(TPS). Methods: An allwater phantom was used to perform TG43 benchmarks with single source and seventeen sources, separately. Furthermore, four real-patient heterogeneous geometries (chestwall, lung, breast and prostate) were used. They were selected based on their clinical representativity of a class of clinical anatomies that pose clear challenges. The plans were used as is(no modification). For each case, TG43 and CCC calculations were performed in the OcB TPS, with TG186-recommended materials properly assigned to ROIs. For comparison, Monte Carlo simulation was run for each case with the same material scheme and grid mesh as TPS calculations. Both modes of CCC (standard and high quality) were tested. Results: For the benchmark case, the CCC dose, when divided by that of TG43, yields hot-n-cold spots in a radial pattern. The pattern of the high mode is denser than that of the standard mode and is representative of angular dicretization. The total deviation ((hot-cold)/TG43) is 18% for standard mode and 11% for high mode. Seventeen dwell positions help to reduce “ray-effect”, with the total deviation to 6% (standard) and 5% (high), respectively. For the four patient cases, CCC produces, as expected, more realistic dose distributions than TG43. A close agreement was observed between CCC and MC for all isodose lines, from 20% and up; the 10% isodose line of CCC appears shifted compared to that of MC. The DVH plots show dose deviations of CCC from MC in small volume, high dose regions (>100% isodose). For patient cases, the difference between standard and high modes is almost undiscernable. Conclusion: OncentraBrachy CCC algorithm marks a significant dosimetry improvement relative to TG43 in real-patient cases. Further researches are recommended regarding the clinical implications of the above

  11. Does the Loss of ARID1A (BAF-250a Expression in Endometrial Clear Cell Carcinomas Have Any Clinicopathologic Significance? A Pilot Assessment

    Directory of Open Access Journals (Sweden)

    Oluwole Fadare, Idris L. Renshaw, Sharon X. Liang

    2012-01-01

    Full Text Available SWI/SNF chromatin-modification complexes use the energy of ATP hydrolysis to remodel nucleosomes and to affect transcription and several cellular processes. Accordingly, their loss of function has been associated with malignant transformation. ARID1A (the expression of whose product, BAF250a, a key complex component, is lost when mutated has recently been identified as a tumor suppressor gene that is mutated in 46-57% of ovarian clear cell carcinoma (CCC. The purposes of this study are to assess the frequency of loss of BAF250a expression in endometrial CCC and whether this loss has any discernable clinicopathologic implications. 34 endometrial carcinomas with a CCC component (including 22 pure CCC, 8 mixed carcinomas with a 10% CCC component, and 4 carcinosarcomas with a CCC epithelial component, were evaluated by immunohistochemistry using a monoclonal antibody directed against the human BAF250a protein. 5 (22.7% of the 22 pure CCC were entirely BAF250a negative, whereas the remainder showed diffuse immunoreactivity. None of 4 carcinosarcomas and only 1 (12.5% of the 8 mixed carcinomas were BAF250a negative. There was no discernable relationship between BAF250a immunoreactivity status and tumor architectural patterns (solid, papillary or tubulocystic areas or cell type (flat, hobnail or polygonal. Of the 22 patients with pure CCC, 14, 2, 3, and 3 were International Federation of Gynecology and Obstetrics stages 1, II, III and IV respectively. Interestingly, all 5 BAF250a negative cases were late stage [stages III or IV] as compared with 1 of 17 BAF250a positive cases (p=0.0002. Thus, 83% (5/6 of all late stage cases were BAF250a [-], as compared with 0 (0% of the 16 early stage (I or II cases (p=.0002. BAF250a negative and positive cases did not show any statistically significant difference regarding patient age and frequency of lymphovascular invasion or myometrial invasion. As may be anticipated from the concentration of late stage cases in

  12. Comparison of continuous compression with regular ventilations versus 30:2 compressions-ventilations strategy during mechanical cardiopulmonary resuscitation in a porcine model of cardiac arrest.

    Science.gov (United States)

    Yang, Zhengfei; Liu, Qingyu; Zheng, Guanghui; Liu, Zhifeng; Jiang, Longyuan; Lin, Qing; Chen, Rui; Tang, Wanchun

    2017-09-01

    A compression-ventilation (C:V) ratio of 30:2 is recommended for adult cardiopulmonary resuscitation (CPR) by the current American Heart Association (AHA) guidelines. However, continuous chest compression (CCC) is an alternative strategy for CPR that minimizes interruption especially when an advanced airway exists. In this study, we investigated the effects of 30:2 mechanical CPR when compared with CCC in combination with regular ventilation in a porcine model. Sixteen male domestic pigs weighing 39±2 kg were utilized. Ventricular fibrillation was induced and untreated for 7 min. The animals were then randomly assigned to receive CCC combined with regular ventilation (CCC group) or 30:2 CPR (VC group). Mechanical chest compression was implemented with a miniaturized mechanical chest compressor. At the same time of beginning of precordial compression, the animals were mechanically ventilated at a rate of 10 breaths-per-minute in the CCC group or with a 30:2 C:V ratio in the VC group. Defibrillation was delivered by a single 150 J shock after 5 min of CPR. If failed to resuscitation, CPR was resumed for 2 min before the next shock. The protocol was stopped if successful resuscitation or at a total of 15 min. The resuscitated animals were observed for 72 h. Coronary perfusion pressure, end-tidal carbon dioxide and carotid blood flow in the VC group were similar to those achieved in the CCC group during CPR. No significant differences were observed in arterial blood gas parameters between two groups at baseline, VF 6 min, CPR 4 min and 30, 120 and 360 min post-resuscitation. Although extravascular lung water index of both groups significantly increased after resuscitation, no distinct difference was found between CCC and VC groups. All animals were successfully resuscitated and survived for 72 h with favorable neurologic outcomes in both groups. However, obviously more numbers of rib fracture were observed in CCC animals in comparison with VC animals. There was no

  13. WE-A-17A-08: Evaluation of the OncentraBrachy Collapsed Cone Convolution Algorithm for Ir-192 Source Using Phantom and Real-Patient Heterogeneous Geometries

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Y; Lacroix, F; Lavallee, M [CHUQ Hotel-Dieu De Quebec, Quebec, QC (Canada); Beaulieu, L [CHUQ Hotel-Dieu De Quebec, Quebec, QC (Canada); Centre Hospitalier University de Quebec, Quebec, QC (Canada)

    2014-06-15

    Purpose: To evaluate the commercially released Collapsed Cone convolution-based(CCC) dose calculation module of the Elekta OncentraBrachy(OcB) treatment planning system(TPS). Methods: An allwater phantom was used to perform TG43 benchmarks with single source and seventeen sources, separately. Furthermore, four real-patient heterogeneous geometries (chestwall, lung, breast and prostate) were used. They were selected based on their clinical representativity of a class of clinical anatomies that pose clear challenges. The plans were used as is(no modification). For each case, TG43 and CCC calculations were performed in the OcB TPS, with TG186-recommended materials properly assigned to ROIs. For comparison, Monte Carlo simulation was run for each case with the same material scheme and grid mesh as TPS calculations. Both modes of CCC (standard and high quality) were tested. Results: For the benchmark case, the CCC dose, when divided by that of TG43, yields hot-n-cold spots in a radial pattern. The pattern of the high mode is denser than that of the standard mode and is representative of angular dicretization. The total deviation ((hot-cold)/TG43) is 18% for standard mode and 11% for high mode. Seventeen dwell positions help to reduce “ray-effect”, with the total deviation to 6% (standard) and 5% (high), respectively. For the four patient cases, CCC produces, as expected, more realistic dose distributions than TG43. A close agreement was observed between CCC and MC for all isodose lines, from 20% and up; the 10% isodose line of CCC appears shifted compared to that of MC. The DVH plots show dose deviations of CCC from MC in small volume, high dose regions (>100% isodose). For patient cases, the difference between standard and high modes is almost undiscernable. Conclusion: OncentraBrachy CCC algorithm marks a significant dosimetry improvement relative to TG43 in real-patient cases. Further researches are recommended regarding the clinical implications of the above

  14. Cancer care coordinators in stage III colon cancer: a cost-utility analysis.

    Science.gov (United States)

    Blakely, Tony; Collinson, Lucie; Kvizhinadze, Giorgi; Nair, Nisha; Foster, Rachel; Dennett, Elizabeth; Sarfati, Diana

    2015-08-05

    There is momentum internationally to improve coordination of complex care pathways. Robust evaluations of such interventions are scarce. This paper evaluates the cost-utility of cancer care coordinators for stage III colon cancer patients, who generally require surgery followed by chemotherapy. We compared a hospital-based nurse cancer care coordinator (CCC) with 'business-as-usual' (no dedicated coordination service) in stage III colon cancer patients in New Zealand. A discrete event microsimulation model was constructed to estimate quality-adjusted life-years (QALYs) and costs from a health system perspective. We used New Zealand data on colon cancer incidence, survival, and mortality as baseline input parameters for the model. We specified intervention input parameters using available literature and expert estimates. For example, that a CCC would improve the coverage of chemotherapy by 33% (ranging from 9 to 65%), reduce the time to surgery by 20% (3 to 48%), reduce the time to chemotherapy by 20% (3 to 48%), and reduce patient anxiety (reduction in disability weight of 33%, ranging from 0 to 55%). Much of the direct cost of a nurse CCC was balanced by savings in business-as-usual care coordination. Much of the health gain was through increased coverage of chemotherapy with a CCC (especially older patients), and reduced time to chemotherapy. Compared to 'business-as-usual', the cost per QALY of the CCC programme was $NZ 18,900 (≈ $US 15,600; 95% UI: $NZ 13,400 to 24,600). By age, the CCC intervention was more cost-effective for colon cancer patients costs, meaning the cost-effectiveness was roughly comparable between ethnic groups. Such a nurse-led CCC intervention in New Zealand has acceptable cost-effectiveness for stage III colon cancer, meaning it probably merits funding. Each CCC programme will differ in its likely health gains and costs, making generalisation from this evaluation to other CCC interventions difficult. However, this evaluation suggests

  15. Multi-channel counter-current chromatography for high-throughput fractionation of natural products for drug discovery.

    Science.gov (United States)

    Wu, Shihua; Yang, Lu; Gao, Yuan; Liu, Xiaoyue; Liu, Feiyan

    2008-02-08

    A multi-channel counter-current chromatography (CCC) method has been designed and fabricated for the high-throughput fractionation of natural products without complications sometimes encountered with other conventional chromatographic systems, such as irreversible adsorptive constituent losses and deactivation, tailing of solute peaks and contamination. It has multiple independent CCC channels and each channel connects independent separation column(s) by parallel flow tubes, and thus the multi-channel CCC apparatus can achieve simultaneously two or more independent chromatographic processes. Furthermore, a high-throughput CCC fractionation method for natural products has been developed by a combination of a new three-channel CCC apparatus and conventional parallel chromatographic devices including pumps, sample injectors, effluent detectors and collectors, and its performance has been displayed on the fractionation of ethyl acetate extracts of three natural materials Solidago canadensis, Suillus placidus, and Trichosanthes kirilowii, which are found to be potent cytotoxic to tumor cell lines in the course of screening the antitumor candidates. By combination of biological screening programs and preparative high-performance liquid chromatography (HPLC) purification, 22.8 mg 6 beta-angeloyloxykolavenic acid and 29.4 mg 6 beta-tigloyloxykolavenic acid for S. canadensis, 25.3mg suillin for S. placidus, and 6.8 mg 23,24-dihydrocucurbitacin B for T. Kirilowii as their major cytotoxic principles were isolated from each 1000 mg crude ethyl acetate extract. Their chemical structures were characterized by electrospray ionization mass spectrometry, one- and two-dimensional nuclear magnetic resonance. The overall results indicate the multi-channel CCC is very useful for high-throughput fractionation of natural products for drug discovery in spite of the solvent balancing requirement and the lower resolution of the shorter CCC columns.

  16. Polymorphisms in the gene for lymphotoxin-alpha predispose to chronic Chagas cardiomyopathy.

    Science.gov (United States)

    Ramasawmy, Rajendranath; Fae, Kellen C; Cunha-Neto, Edecio; Müller, Natalie G; Cavalcanti, Vanessa L; Ferreira, Renata C; Drigo, Sandra A; Ianni, Barbara; Mady, Charles; Goldberg, Anna C; Kalil, Jorge

    2007-12-15

    Chagas disease, caused by Trypanosoma cruzi infection, displays clinical heterogeneity and may be attributable to differential genetic susceptibility. Chronic Chagas cardiomyopathy (CCC) develops only in a subset of T. cruzi-infected individuals and may lead to heart failure that has a worse clinical course and that leads to reduced life expectancy, compared with heart failure of other etiologies. Proinflammatory cytokines play a key role in the development of CCC. Clinical, genetic, and epidemiological studies have linked lymphotoxin-alpha (LTA), a proinflammatory cytokine, to coronary artery disease and myocardial infarction. We used polymerase chain reaction to genotype the LTA +80A-->C and LTA +252A-->G variants in 169 patients with CCC and in 76 T. cruzi-infected asymptomatic (ASY) patients. Homozygosity with respect to the LTA +80C and LTA +252G alleles was significantly more frequent in the patients with CCC than in the ASY patients (homozygosity for LTA +80C, 47% vs. 33%; homozygosity for LTA +252G, 16% vs. 8%). Haplotype LTA +80A-252A was associated with protection against CCC, whereas haplotype LTA +80C-252G was associated with susceptibility to CCC. Furthermore, homozygosity for the LTA +80A allele correlated with the lowest levels of plasmatic tumor-necrosis factor-alpha. Our results suggest that the study of genetic variations in patients with Chagas disease may help in the identification of individuals at increased risk of progressing to CCC and, by providing early treatment, reduce the morbidity and mortality associated with this disease.

  17. Solubility and bioavailability of stabilized amorphous calcium carbonate.

    Science.gov (United States)

    Meiron, Oren E; Bar-David, Elad; Aflalo, Eliahu D; Shechter, Assaf; Stepensky, David; Berman, Amir; Sagi, Amir

    2011-02-01

    Since its role in the prevention of osteoporosis in humans was proven some 30 years ago, calcium bioavailability has been the subject of numerous scientific studies. Recent technology allowing the production of a stable amorphous calcium carbonate (ACC) now enables a bioavailability analysis of this unique form of calcium. This study thus compares the solubility and fractional absorption of ACC, ACC with chitosan (ACC-C), and crystalline calcium carbonate (CCC). Solubility was evaluated by dissolving these preparations in dilute phosphoric acid. The results demonstrated that both ACC and ACC-C are more soluble than CCC. Fractional absorption was evaluated by intrinsically labeling calcium carbonate preparations with (45)Ca, orally administrated to rats using gelatin capsules. Fractional absorption was determined by evaluating the percentage of the administrated radioactive dose per milliliter that was measured in the serum, calcium absorption in the femur, and whole-body retention over a 34-hour period. Calcium serum analysis revealed that calcium absorption from ACC and ACC-C preparations was up to 40% higher than from CCC, whereas retention of ACC and ACC-C was up to 26.5% higher than CCC. Absorbed calcium in the femurs of ACC-administrated rats was 30% higher than in CCC-treated animals, whereas 15% more calcium was absorbed following ACC-C treatment than following CCC treatment. This study demonstrates the enhanced solubility and bioavailability of ACC over CCC. The use of stable ACC as a highly bioavailable dietary source for calcium is proposed based on the findings of this study. Copyright © 2011 American Society for Bone and Mineral Research.

  18. Filtering mountain landscapes and hydrology through sediment transport

    Science.gov (United States)

    Phillips, C. B.; Jerolmack, D. J.

    2013-12-01

    Long-term denudation of landscapes is balanced, and sometimes limited by, the sediment mass flux leaving the system through rivers. Suspended sediment represents the largest fraction of mass exiting the landscape, however coarse bed load transport may be the rate-limiting process of landscape denudation through its control on bedrock channel erosion and incision. We present research linking particle mechanics for a coarse alluvial gravel stream at the flood scale to particle dynamics at the annual timescale, and examine the implications of these results on channel geometry and the hydrology of mountain rivers. We examine the transport dynamics of individual cobbles tagged with passive radio transponder tags from the Mameyes River in the Luquillo Mountains of Puerto Rico, in both bedrock and alluvial stretches. These data are composed of measured 'flight' lengths for each transported particle, the fraction of tagged particles mobilized, and high-resolution river stage measurements. At the single flood scale, measured tracer particle flight lengths are exponentially distributed, and modal flight lengths scale linearly with excess shear velocity (U*-U*c). This is in quantitative agreement with recent theory and laboratory experiments, suggesting that moving particles' velocity is determined by momentum balance with the fluid. Examining tracer displacement at long timescales we use a dimensionless impulse (I*) - obtained by integrating the cumulative excess shear velocity over the duration of a flood (normalized by grain size) - and find that the mean travel distance collapses onto a linear relationship. Data show that partial bed load transport with intermittent motion is the dominant mode for the duration of record. Examining flood statistics, we find that the frequency-magnitude distribution of shear velocity is a power law; however, this scaling is truncated at the threshold of motion, beyond which it displays exponential scaling. The thin-tailed scaling of (U*-U*c

  19. European laws on compulsory commitment to care of persons suffering from substance use disorders or misuse problems- a comparative review from a human and civil rights perspective.

    Science.gov (United States)

    Israelsson, Magnus; Nordlöf, Kerstin; Gerdner, Arne

    2015-08-28

    Laws on compulsory commitment to care (CCC) in mental health, social and criminal legislation for adult persons with alcohol and/or drug dependence or misuse problems are constructed to address different scenarios related to substance use disorders. This study examines how such CCC laws in European states vary in terms of legal rights, formal orders of decision and criteria for involuntary admission, and assesses whether three legal frameworks (criminal, mental and social law) equally well ensure human and civil rights. Thirty-nine laws, from 38 countries, were analysed. Respondents replied in web-based questionnaires concerning a) legal rights afforded the persons with substance use problems during commitment proceedings, b) sources of formal application, c) instances for decision on admission, and d) whether or not 36 different criteria could function as grounds for decisions on CCC according to the law in question. Analysis of a-c were conducted in bivariate cross-tabulations. The 36 criteria for admission were sorted in criteria groups based on principal component analysis (PCA). To investigate whether legal rights, decision-making authorities or legal criteria may discriminate between types of law on CCC, discriminant analyses (DA) were conducted. There are few differences between the three types of law on CCC concerning legal rights afforded the individual. However, proper safeguards of the rights against unlawful detention seem still to be lacking in some CCC laws, regardless type of law. Courts are the decision-making body in 80 % of the laws, but this varies clearly between law types. Criteria for CCC also differ between types of law, i.e. concerning who should be treated: dependent offenders, persons with substance use problems with acting out or aggressive behaviors, or other vulnerable persons with alcohol or drug problems. The study raises questions concerning whether various European CCC laws in relation to substance use disorder or misuse problems

  20. A clinical study of lung cancer dose calculation accuracy with Monte Carlo simulation.

    Science.gov (United States)

    Zhao, Yanqun; Qi, Guohai; Yin, Gang; Wang, Xianliang; Wang, Pei; Li, Jian; Xiao, Mingyong; Li, Jie; Kang, Shengwei; Liao, Xiongfei

    2014-12-16

    The accuracy of dose calculation is crucial to the quality of treatment planning and, consequently, to the dose delivered to patients undergoing radiation therapy. Current general calculation algorithms such as Pencil Beam Convolution (PBC) and Collapsed Cone Convolution (CCC) have shortcomings in regard to severe inhomogeneities, particularly in those regions where charged particle equilibrium does not hold. The aim of this study was to evaluate the accuracy of the PBC and CCC algorithms in lung cancer radiotherapy using Monte Carlo (MC) technology. Four treatment plans were designed using Oncentra Masterplan TPS for each patient. Two intensity-modulated radiation therapy (IMRT) plans were developed using the PBC and CCC algorithms, and two three-dimensional conformal therapy (3DCRT) plans were developed using the PBC and CCC algorithms. The DICOM-RT files of the treatment plans were exported to the Monte Carlo system to recalculate. The dose distributions of GTV, PTV and ipsilateral lung calculated by the TPS and MC were compared. For 3DCRT and IMRT plans, the mean dose differences for GTV between the CCC and MC increased with decreasing of the GTV volume. For IMRT, the mean dose differences were found to be higher than that of 3DCRT. The CCC algorithm overestimated the GTV mean dose by approximately 3% for IMRT. For 3DCRT plans, when the volume of the GTV was greater than 100 cm(3), the mean doses calculated by CCC and MC almost have no difference. PBC shows large deviations from the MC algorithm. For the dose to the ipsilateral lung, the CCC algorithm overestimated the dose to the entire lung, and the PBC algorithm overestimated V20 but underestimated V5; the difference in V10 was not statistically significant. PBC substantially overestimates the dose to the tumour, but the CCC is similar to the MC simulation. It is recommended that the treatment plans for lung cancer be developed using an advanced dose calculation algorithm other than PBC. MC can accurately

  1. PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation.

    Science.gov (United States)

    Zhang, Wen; Chen, Jieliang; Wu, Min; Zhang, Xiaonan; Zhang, Min; Yue, Lei; Li, Yaming; Liu, Jiangxia; Li, Baocun; Shen, Fang; Wang, Yang; Bai, Lu; Protzer, Ulrike; Levrero, Massimo; Yuan, Zhenghong

    2017-08-01

    Chronic hepatitis B virus (HBV) infection remains a major health problem worldwide. The covalently closed circular DNA (cccDNA) minichromosome, which serves as the template for the transcription of viral RNAs, plays a key role in viral persistence. While accumulating evidence suggests that cccDNA transcription is regulated by epigenetic machinery, particularly the acetylation of cccDNA-bound histone 3 (H3) and H4, the potential contributions of histone methylation and related host factors remain obscure. Here, by screening a series of methyltransferases and demethylases, we identified protein arginine methyltransferase 5 (PRMT5) as an effective restrictor of HBV transcription and replication. In cell culture-based models for HBV infection and in liver tissues of patients with chronic HBV infection, we found that symmetric dimethylation of arginine 3 on H4 on cccDNA was a repressive marker of cccDNA transcription and was regulated by PRMT5 depending on its methyltransferase domain. Moreover, PRMT5-triggered symmetric dimethylation of arginine 3 on H4 on the cccDNA minichromosome involved an interaction with the HBV core protein and the Brg1-based human SWI/SNF chromatin remodeler, which resulted in down-regulation of the binding of RNA polymerase II to cccDNA. In addition to the inhibitory effect on cccDNA transcription, PRMT5 inhibited HBV core particle DNA production independently of its methyltransferase activity. Further study revealed that PRMT5 interfered with pregenomic RNA encapsidation by preventing its interaction with viral polymerase protein through binding to the reverse transcriptase-ribonuclease H region of polymerase, which is crucial for the polymerase-pregenomic RNA interaction. PRMT5 restricts HBV replication through a two-part mechanism including epigenetic suppression of cccDNA transcription and interference with pregenomic RNA encapsidation; these findings improve the understanding of epigenetic regulation of HBV transcription and host

  2. Quantitative proton magnetic resonance spectroscopy of the normal liver and malignant hepatic lesions at 3.0 Tesla

    International Nuclear Information System (INIS)

    Fischbach, F.; Thormann, M.; Ricke, J.; Schirmer, T.; Freund, T.; Bruhn, H.

    2008-01-01

    This comparative study of tumour patients and volunteers aimed at differentiating liver parenchyma from neoplastic lesions by using localised 1 H MRS at 3.0 T as an adjunct to MRI. In total 186 single-voxel proton spectra of the liver were acquired at 3.0 T using the body transmit receive coil. Consecutive stacks of breath-hold spectra were acquired in the PRESS technique at a short echo time of 35 ms and a repetition time of 2,000 ms. Processing of the spectra included spectral alignment with the software package SAGE and quantitative processing with LCModel. The resulting metabolite concentrations were presented in arbitrary units relative to the internal water. In general, the spectra showed four main groups of resonances originating from the methyl protons (0.8-1.1 ppm) and methylene protons of the lipids (1.1-1.5 ppm; 2.0-2.2 ppm) as well as the methyl protons of choline-containing compounds (CCC) at 3.2 ppm. Overall, the CCC and lipid values in malignant liver tumours showed no significant differences to liver parenchyma. On average, total lipid measurements in normal liver parenchyma increased with age, while those of the CCC did not show pertinent changes. Significant differences between the contents of CCC in malignant liver tumours and normal liver parenchyma were not observed, because in patients and volunteers normal liver tissue showed a large variability in the content of CCC. (orig.)

  3. Efficient micropropagation and chlorocholine chloride induced stevioside production of Stevia rebaudiana Bertoni.

    Science.gov (United States)

    Dey, Avishek; Kundu, Sayanti; Bandyopadhyay, Abhijit; Bhattacharjee, Aloke

    2013-01-01

    A promising method of micropropagation of Stevia rebaudiana Bertoni has been developed with an aim to increase the biomass, survivability of the plantlets and stevioside production, using chlorocholine chloride (CCC). Microshoots transferred to the MS medium containing different combinations CCC and IBA were found to be most effective in terms of growth pattern, hardening ability of the plantlets and stevioside content, compared to MS medium containing either IBA or CCC. Among other combinations tested, MS medium supplemented with 3 mg/l CCC and 3 mg/l IBA was found most effective in inducing significant changes like reduced shoot length, increased number of roots, higher leaf size, increased biomass and chlorophyll retaining capacity, higher survival percentage and most importantly the elevated stevioside content. Collectively, the major observations of this research indicate that application of CCC in micropropagation of S. rebaudiana Bertoni is a promising approach and has commercial prospects. Copyright © 2012 Académie des sciences. Published by Elsevier SAS. All rights reserved.

  4. High-level secretion of tissue factor-rich extracellular vesicles from ovarian cancer cells mediated by filamin-A and protease-activated receptors.

    Science.gov (United States)

    Koizume, Shiro; Ito, Shin; Yoshioka, Yusuke; Kanayama, Tomohiko; Nakamura, Yoshiyasu; Yoshihara, Mitsuyo; Yamada, Roppei; Ochiya, Takahiro; Ruf, Wolfram; Miyagi, Etsuko; Hirahara, Fumiki; Miyagi, Yohei

    2016-01-01

    Thromboembolic events occur frequently in ovarian cancer patients. Tissue factor (TF) is often overexpressed in tumours, including ovarian clear-cell carcinoma (CCC), a subtype with a generally poor prognosis. TF-coagulation factor VII (fVII) complexes on the cell surface activate downstream coagulation mechanisms. Moreover, cancer cells secrete extracellular vesicles (EVs), which act as vehicles for TF. We therefore examined the characteristics of EVs produced by ovarian cancer cells of various histological subtypes. CCC cells secreted high levels of TF within EVs, while the high-TF expressing breast cancer cell line MDA-MB-231 shed fewer TF-positive EVs. We also found that CCC tumours with hypoxic tissue areas synthesised TF and fVII in vivo, rendering the blood of xenograft mice bearing these tumours hypercoagulable compared with mice bearing MDA-MB-231 tumours. Incorporation of TF into EVs and secretion of EVs from CCC cells exposed to hypoxia were both dependent on the actin-binding protein, filamin-A (filA). Furthermore, production of these EVs was dependent on different protease-activated receptors (PARs) on the cell surface. These results show that CCC cells could produce large numbers of TF-positive EVs dependent upon filA and PARs. This phenomenon may be the mechanism underlying the increased incidence of venous thromboembolism in ovarian cancer patients.

  5. Serum hepatitis B core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular DNA in chronic hepatitis B.

    Science.gov (United States)

    Chen, En-Qiang; Feng, Shu; Wang, Meng-Lan; Liang, Ling-Bo; Zhou, Ling-Yun; Du, Ling-Yao; Yan, Li-Bo; Tao, Chuan-Min; Tang, Hong

    2017-03-14

    Recently, hepatitis B core-related antigen (HBcrAg) has been suggested as an additional marker of hepatitis B virus (HBV) infection. This study aimed to investigate whether serum quantitative HBcrAg (qHBcrAg) was a satisfactory surrogate marker of intrahepatic covalently closed circular DNA (cccDNA). A total of 139 patients with liver biopsy were enrolled, consisting of 59 patients in immune tolerance (IT) phase, 52 patients in immune clearance (IC) phase, 18 patients in low-replication (LR) phase, and 10 patients in reactivation phase. All patients in IC phase have received entecavir (ETV) therapy, and 32 of them undergone a second liver biopsy at 24 months. Among those patients, qHBcrAg was strongly correlated with intrahepatic cccDNA, which is superior to that of qHBsAg and HBV DNA. And similar findings were also observed in patients in IT, IC, LR and reactivation phases. Among the 32 ETV-treated patients with a second liver biopsy in IC phase, the decline of intrahepatic cccDNA was accompanied by changes in both qHBcrAg and qHBsAg. However, as compared to qHBsAg, the change of qHBcrAg was more strongly associated with intrahepatic cccDNA-decline. In summary, serum qHBcrAg should be a satisfactory surrogate of intrahepatic HBV cccDNA in CHB patients.

  6. How do clinical competency committees use different sources of data to assess residents' performance on the internal medicine milestones?A mixed methods pilot study.

    Science.gov (United States)

    Ekpenyong, Andem; Baker, Elizabeth; Harris, Ilene; Tekian, Ara; Abrams, Richard; Reddy, Shalini; Park, Yoon Soo

    2017-10-01

    This study examines how Clinical Competency Committees (CCCs) synthesize assessment data to make judgments about residents' clinical performances. Between 2014 and 2015, after four six-month reporting periods to the Accreditation Council for Graduate Medical Education (ACGME), 7 of 16 CCC faculty at Rush University Medical Center completed questionnaires focused on their perspectives about rating residents on their achievement of the milestones and participated in a focus group. Qualitative data were analyzed using grounded theory. Milestones ratings for two six-month ACGME reporting cycles (n = 100 categorical residents) were also analyzed. CCC members weighted resident rotation ratings highest (weight = 37%), followed by faculty rotation comments (weight = 27%) and personal experience with residents (weight = 14%) for making judgments about learner's milestone levels. Three assessment issues were identified from qualitative analyses: (1) "design issues" (e.g. problems with available data or lack thereof); (2) "synthesis issues" (e.g. factors influencing ratings and decision-making processes) and (3) "impact issues" (e.g. how CCC generated milestones ratings are used). Identifying factors that affect assessment at all stages of the CCC process can contribute to improving assessment systems, including support for faculty development for CCCs. Recognizing challenges in synthesizing first and second-hand assessment data is an important step in understanding the CCC decision-making process.

  7. Effect of cycocel on photosynthetic activity and essential oil of fennel (Foeniculum vulgare Mill. under drought stress

    Directory of Open Access Journals (Sweden)

    Fatemeh Nouri

    2014-12-01

    Full Text Available Drought stress is one of the most important and most common environmental stresses that limit plant growth. Photosynthesis is the main determinant of plant growth and its retention ability under environmental stress condition is important for preservation of growth stability. To study the effect of spraying CCC on photosynthesis activity and essential oil content on 'Foeniculum vulgare', an experiment was done in split plot design based on complete block with four replications in research field of University of Zanjan in 2011. Levels of drought stress included, control, soft stress (when 30% of available water was out of soil, severe stress (when 90% of available water was out of soil, and three concentration of CCC 0, 1500 and 3000 mg/L. The results showed that between rates foliar application on physiologic characteristics as photosynthesis rate, transpiration severity, RWC and TΔ intercellular (Ci, stomata conductivity, mesophyll conductivity and essential oil content was significant. By spraying 3000 mg/L CCC, balanced the plant position against drought stress and could reduce negative effect. Foliar application of CCC caused significant increase in photosynthesis rate, mesophyll conductivity and significant decrease stomata conductivity, transpiration severity under drought stress and could increase essential oil content under soft stress. In this study, foliar application of CCC to content 3000 mg/L had the highest effect on this characters.

  8. Myocardial Gene Expression of T-bet, GATA-3, Ror-γt, FoxP3, and Hallmark Cytokines in Chronic Chagas Disease Cardiomyopathy: An Essentially Unopposed TH1-Type Response

    Directory of Open Access Journals (Sweden)

    Luciana Gabriel Nogueira

    2014-01-01

    Full Text Available Background. Chronic Chagas disease cardiomyopathy (CCC, a late consequence of Trypanosoma cruzi infection, is an inflammatory cardiomyopathy with prognosis worse than those of noninflammatory etiology (NIC. Although the T cell-rich myocarditis is known to play a pathogenetic role, the relative contribution of each of the functional T cell subsets has never been thoroughly investigated. We therefore assessed gene expression of cytokines and transcription factors involved in differentiation and effector function of each functional T cell subset (TH1/TH2/TH17/Treg in CCC, NIC, and heart donor myocardial samples. Methods and Results. Quantitative PCR showed markedly upregulated expression of IFN-γ and transcription factor T-bet, and minor increases of GATA-3; FoxP3 and CTLA-4; IL-17 and IL-18 in CCC as compared with NIC samples. Conversely, cytokines expressed by TH2 cells (IL-4, IL-5, and IL-13 or associated with Treg (TGF-β and IL-10 were not upregulated in CCC myocardium. Expression of TH1-related genes such as T-bet, IFN-γ, and IL-18 correlated with ventricular dilation, FoxP3, and CTLA-4. Conclusions. Results are consistent with a strong local TH1-mediated response in most samples, possibly associated with pathological myocardial remodeling, and a proportionally smaller FoxP3+CTLA4+ Treg cell population, which is unable to completely curb IFN-γ production in CCC myocardium, therefore fueling inflammation.

  9. Spectrometric study of the folding process of i-motif-forming DNA sequences upstream of the c-kit transcription initiation site

    International Nuclear Information System (INIS)

    Bucek, Pavel; Gargallo, Raimundo; Kudrev, Andrei

    2010-01-01

    The c-kit oncogene shows a cytosine-rich DNA region upstream of the transcription initiation site which forms an i-motif structure at slightly acidic pH values (Bucek et al. ). In the present study, the pH-induced formation of i-motif - forming sequences 5'-CCC CTC CCT CGC GCC CGC CCG-3' (ckitC1, native), 5'-CCC TTC CCT TGT GCC CGC CCG-3' (ckitC2) and 5'-CCCTT CCC TTTTT CCC T CCC T-3' (ckitC3) was studied by spectroscopic techniques, such as UV molecular absorption and circular dichroism (CD), in tandem with two multivariate data analysis methods, the hard modelling-based matrix method and the soft modelling-based MCR-ALS approach. Use of the hard chemical modelling enabled us to propose the equilibrium model, which describes spectral changes as functions of solution acidity. Additionally, the intrinsic protonation constant, K in , and the cooperativity parameters, ω c , and ω a , were calculated from the fitting procedure of the coupled CD and molecular absorption spectra. In the case of ckitC2 and ckitC3, the hard model correctly reproduced the spectral variations observed experimentally. The results indicated that folding was accompanied by a cooperative process, i.e. the enhancement of protonated structure stability upon protonation. In contrast, unfolding was accompanied by an anticooperative process. Finally, folding of the native sequence, ckitC1, seemed to follow a more complex mechanism.

  10. PREDICTIVE FACTORS FOR THE PROGRESSION OF CHRONIC CHAGAS CARDIOMYOPATHY IN PATIENTS WITHOUT LEFT VENTRICULAR DYSFUNCTION

    Directory of Open Access Journals (Sweden)

    Silvana de Araújo SILVA

    2015-04-01

    Full Text Available The identification of predictors for the progression of chronic Chagas cardiomyopathy (CCC is essential to ensure adequate patient management. This study looked into a non-concurrent cohort of 165 CCC patients between 1985 and 2010 for independent predictors for CCC progression. The outcomes were worsening of the CCC scores and the onset of left ventricular dysfunction assessed by means of echo-Doppler cardiography. Patients were analyzed for social, demographic, epidemiologic, clinical and workup-related variables. A descriptive analysis was conducted, followed by survival curves based on univariate (Kaplan-Meier and Cox’s univariate model and multivariate (Cox regression model analysis. Patients were followed from two to 20 years (mean: 8.2. Their mean age was 44.8 years (20-77. Comparing both iterations of the study, in the second there was a statistically significant increase in the PR interval and in the QRS duration, despite a reduction in heart rates (Wilcoxon < 0.01. The predictors for CCC progression in the final regression model were male gender (HR = 2.81, Holter monitoring showing pauses equal to or greater than two seconds (HR = 3.02 increased cardiothoracic ratio (HR = 7.87 and time of use of digitalis (HR = 1.41. Patients with multiple predictive factors require stricter follow-up and treatment.

  11. Expression of Tissue Factor in Epithelial Ovarian Carcinoma Is Involved in the Development of Venous Thromboembolism.

    Science.gov (United States)

    Sakurai, Manabu; Matsumoto, Koji; Gosho, Masahiko; Sakata, Akiko; Hosokawa, Yoshihiko; Tenjimbayashi, Yuri; Katoh, Takashi; Shikama, Ayumi; Komiya, Haruna; Michikami, Hiroo; Tasaka, Nobutaka; Akiyama-Abe, Azusa; Nakao, Sari; Ochi, Hiroyuki; Onuki, Mamiko; Minaguchi, Takeo; Yoshikawa, Hiroyuki; Satoh, Toyomi

    2017-01-01

    Our 2007 study of 32 patients with ovarian cancer reported the possible involvement of tissue factor (TF) in the development of venous thromboembolism (VTE) before treatment, especially in clear cell carcinoma (CCC). This follow-up study further investigated this possibility in a larger cohort. We investigated the intensity of TF expression (ITFE) and other variables for associations with VTE using univariate and multivariate analyses in 128 patients with epithelial ovarian cancer initially treated between November 2004 and December 2010, none of whom had received neoadjuvant chemotherapy. Before starting treatment, all patients were ultrasonographically screened for VTE. The ITFE was graded based on immunostaining of surgical specimens. Histological types were serous carcinoma (n = 42), CCC (n = 12), endometrioid carcinoma (n = 15), mucinous carcinoma (n = 53), and undifferentiated carcinoma (n = 6). The prevalence of VTE was significantly higher in CCC (34%) than in non-CCC (17%, P = 0.03). As ITFE increased, the frequencies of CCC and VTE increased significantly (P epithelial ovarian cancer may involve TF expression in cancer tissues.

  12. Gatekeepers of health: A qualitative assessment of child care centre staff's perspectives, practices and challenges to enteric illness prevention and management in child care centres

    Directory of Open Access Journals (Sweden)

    Adams Cindy L

    2008-06-01

    Full Text Available Abstract Background Enteric outbreaks associated with child care centres (CCC have been well documented internationally and in Canada. The current literature focuses on identifying potential risk factors for introduction and transmission of enteric disease, but does not examine why these risk factors happen, how the risk is understood and managed by the staff of CCCs, or what challenges they experience responding to enteric illness. The purpose of this study was to explore the understanding, knowledge and actions of CCC staff regarding enteric illness and outbreaks, and to identify challenges that staff encounter while managing them. Methods Focus groups were conducted with staff of regulated CCCs in Southern Ontario. Five focus groups were held with 40 participants. An open ended style of interviewing was used. Data were analyzed using content analysis. Results CCC staff play an important role in preventing and managing enteric illness. Staff used in-depth knowledge of the children, the centre and their personal experiences to assist in making decisions related to enteric illness. The decisions and actions may differ from guidance provided by public health officials, particularly when faced with challenges related to time, money, staffing and parents. Conclusion CCC staff relied on experience and judgment in coordination with public health information to assist decision-making in the management of enteric illness and outbreaks. Advice and guidance from public health officials to CCC staff needs to be consistent yet flexible so that it may be adapted in a variety of situations and meet regulatory and public health requirements.

  13. Continent catheterizable conduit for urinary diversion in children: Applicability and acceptability

    Directory of Open Access Journals (Sweden)

    Shailesh Solanki

    2015-01-01

    Full Text Available Background: Continent catheterizable conduit (CCC has made clean intermittent catheterization (CIC painless and easy. It is applicable in diverse clinical conditions. Nonetheless, convincing the parents for the need of conduit procedure is still difficult. Materials and Methods: A prospective study, included children who underwent CCC procedure from March 2008 to February 2013. The data were assessed for; diagnosis, type of conduit, number of preoperative counselling sessions before acceptance, role of "self-help group" in decision making, parental concern and satisfaction for the procedure. Results: Twenty-nine patients (males; 24, females; 5 underwent CCC procedure for various clinical conditions. The multiple preoperative counselling sessions and creation of "self-help groups" were helped them for decision making. The main concerns among parents were: (1 Impact of procedure on future fertility and sexual life. (2 Patency of native urethral channel. (3 Permanent urinary stoma over the abdomen. Conclusion: CCC procedures are applicable to a wide array of clinical situations with a good outcome. The acceptability of the CCC procedure improves with preoperative counselling of parent/child, initiation of preoperative per urethral CIC and creation of self-help groups.

  14. GUI2QAD, Graphical Interface for QAD-CGPIC, Point Kernel for Shielding Calculations

    International Nuclear Information System (INIS)

    2001-01-01

    1 - Description of program or function: GUI2QAD is an aid in preparation of input for the included QAD-CGPIC program, which is based on CCC-493/QAD-CGGP and PICTURE. QAD-CGPIC, which is included in this distribution, is a Fortran code for neutron and gamma-ray shielding calculations by the point kernel method. Provision is available to interactively view the geometry of the system. QAD-CG calculates fast-neutron and gamma-ray penetration through various shield configurations defined by combinatorial geometry specifications. The code can use the ANS-6.4.3 1990 buildup factor compilation (26 materials). 2 - Methods:The code QAD-CGPIC is based on point kernel method and has a provision to select either GP or Capo's build up factors. 3 - Restrictions on the complexity of the problem: Details on restrictions and limitations are available in the RSICC code manual CCC-493/QAD-CGGP. Because CCC-493 was obsoleted by CCC-645/QAD-CGGP-A, the CCC-493 documentation is not online but is included with this package. This package includes a Graphical User Interface to facilitate use

  15. Pore structure of natural and regenerated soil aggregates

    DEFF Research Database (Denmark)

    Naveed, Muhammad; Arthur, Emmanuel; de Jonge, Lis Wollesen

    2014-01-01

    Quantitative characterization of aggregate pore structure can reveal the evolution of aggregates under different land use and management practices and their effects on soil processes and functions. Advances in X-ray Computed Tomography (CT) provide powerful means to conduct such characterization....... This study examined aggregate pore structure of three differently managed same textured Danish soils (mixed forage cropping, MFC; mixed cash cropping, MCC; cereal cash cropping, CCC) for (i) natural aggregates, and (ii) aggregates regenerated after 20 months of incubation. In total, 27 aggregates (8-16 mm...... pore diameter of 200 and 170 Hm, respectively. Pore shape analysis indicated that CCC and MFC aggregates had an abundance of rounded and elongated pores, respectively, and those of MCC were in-between CCC and MFC. Aggregate pore structure development in the lysimeters was nearly similar irrespective...

  16. Resolution of gram quantities of racemates by high-speed counter-current chromatography.

    Science.gov (United States)

    Ma, Y; Ito, Y; Foucault, A

    1995-06-02

    Gram quantities of (+/-)-dinitrobenzoyl amino acids were separated by high-speed counter-current chromatography (CCC) using N-dodecanoyl-L-proline-3,5-dimethylanilide as a chiral selector (CS). Standard and pH-zone-refining CCC techniques were compared. By using the standard technique, 10 mg to a maximum of 1 g of samples was resolved in 2-9 h simply by increasing the concentration of the CS in the stationary phase. By using pH-zone-refining CCC, even more sample (2 g) was efficiently separated in less time (3 h). In both techniques, leakage of CS from the column was negligible. The method requires no solid support and the same column can be used repeatedly to separate a variety of enantiomers by dissolving appropriate chiral selectors in the stationary phase.

  17. A new measurement tool for characterization of superconducting rf accelerator cavities using high-performance LTS SQUIDs

    Energy Technology Data Exchange (ETDEWEB)

    Vodel, W [Friedrich-Schiller-University Jena, Helmholtzweg 5, 07743 Jena (Germany); Neubert, R [Friedrich-Schiller-University Jena, Helmholtzweg 5, 07743 Jena (Germany); Nietzsche, S [Friedrich-Schiller-University Jena, Helmholtzweg 5, 07743 Jena (Germany); Seidel, P [Friedrich-Schiller-University Jena, Helmholtzweg 5, 07743 Jena (Germany); Knaack, K [DESY Hamburg (Germany); Wittenburg, K [DESY Hamburg (Germany); Peters, A [Heidelberger Ionenstrahl-Therapiezentrum, Heidelberg (Germany)

    2007-11-15

    This paper presents a new system to measure very low currents in an accelerator environment, using a cryogenic current comparator (CCC). In principle a CCC is a conventional current transformer using the high-performance SQUID technology to sense the magnetic fields caused by the beam current. Since the system is sensitive on a pA level, it is an optimum device to detect dark currents of superconducting cavities. The system presented here is designed for the test facilities of the superconducting accelerator modules for the European XFEL at the Deutsches Elektronen-Synchrotron (DESY) in Hamburg. Measurements in a quiet environment showed that an intrinsic noise level of the CCC of 40 pA Hz{sup -1/2} could be achieved.

  18. Implementing a Rule-Based Contract Compliance Checker

    Science.gov (United States)

    Strano, Massimo; Molina-Jimenez, Carlos; Shrivastava, Santosh

    The paper describes the design and implementation of an independent, third party contract monitoring service called Contract Compliance Checker (CCC). The CCC is provided with the specification of the contract in force, and is capable of observing and logging the relevant business-to-business (B2B) interaction events, in order to determine whether the actions of the business partners are consistent with the contract. A contract specification language called EROP (for Events, Rights, Obligations and Prohibitions) for the CCC has been developed based on business rules, that provides constructs to specify what rights, obligation and prohibitions become active and inactive after the occurrence of events related to the execution of business operations. The system has been designed to work with B2B industry standards such as ebXML and RosettaNet.

  19. Evaluation of the benefits and risks of introducing Ebola community care centers, Sierra Leone.

    Science.gov (United States)

    Kucharski, Adam J; Camacho, Anton; Checchi, Francesco; Waldman, Ron; Grais, Rebecca F; Cabrol, Jean-Clement; Briand, Sylvie; Baguelin, Marc; Flasche, Stefan; Funk, Sebastian; Edmunds, W John

    2015-03-01

    In some parts of western Africa, Ebola treatment centers (ETCs) have reached capacity. Unless capacity is rapidly scaled up, the chance to avoid a generalized Ebola epidemic will soon diminish. The World Health Organization and partners are considering additional Ebola patient care options, including community care centers (CCCs), small, lightly staffed units that could be used to isolate patients outside the home and get them into care sooner than otherwise possible. Using a transmission model, we evaluated the benefits and risks of introducing CCCs into Sierra Leone's Western Area, where most ETCs are at capacity. We found that use of CCCs could lead to a decline in cases, even if virus transmission occurs between CCC patients and the community. However, to prevent CCC amplification of the epidemic, the risk of Ebola virus-negative persons being exposed to virus within CCCs would have to be offset by a reduction in community transmission resulting from CCC use.

  20. Design review report FFTF interim storage cask

    International Nuclear Information System (INIS)

    Scott, P.L.

    1995-01-01

    Final Design Review Report for the FFTF Interim Storage Cask. The Interim Storage Cask (ISC) will be used for long term above ground dry storage of FFTF irradiated fuel in Core Component Containers (CCC)s. The CCC has been designed and will house assemblies that have been sodium washed in the IEM Cell. The Solid Waste Cask (SWC) will transfer a full CCC from the IEM Cell to the RSB Cask Loading Station where the ISC will be located to receive it. Once the loaded ISC has been sealed at the RSB Cask Loading Station, it will be transferred by facility crane to the DSWC Transporter. After the ISC has been transferred to the Interim Storage Area (ISA), which is yet to be designed, a mobile crane will be used to place the ISC in its final storage location

  1. Final work plan : environmental site investigation at Sylvan Grove, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M. (Environmental Science Division)

    2012-07-15

    In 1998, carbon tetrachloride was found above the maximum contaminant level (MCL) of 5 {micro}g/L in groundwater from one private livestock well at Sylvan Grove, Kansas, by the Kansas Department of Health and Environment (KDHE). The 1998 KDHE sampling was conducted under the U.S. Department of Agriculture (USDA) private well sampling program. The Commodity Credit Corporation (CCC), a USDA agency, operated a grain storage facility in Sylvan Grove from 1954 to1966. Carbon tetrachloride is the contaminant of primary concern at sites associated with former CCC/USDA grain storage operations. Sylvan Grove is located in western Lincoln County, approximately 60 mi west of Salina (Figure 1.1). To determine whether the former CCC/USDA facility at Sylvan Grove is a potential contaminant source and its possible relationship to the contamination in groundwater, the CCC/USDA has agreed to conduct an investigation, in accordance with the Intergovernmental Agreement between the KDHE and the Farm Service Agency (FSA) of the USDA. This Work Plan presents historical data related to previous investigations, grain storage operations, local private wells and public water supply (PWS) wells, and local geologic and hydrogeologic conditions at Sylvan Grove. The findings from a review of all available documents are discussed in Section 2. On the basis of the analyses of historical data, the following specific technical objectives are proposed for the site investigation at Sylvan Grove: (1) Evaluate the potential source of carbon tetrachloride at the former CCC/USDA facility; (2) Determine the relationship of potential contamination (if present) at the former CCC/USDA facility to contamination identified in 1998 in groundwater samples from one private well to the west; and (3) Delineate the extent of potential contamination associated with the former CCC/USDA facility. The detailed scope of work is outlined in Section 3. The results of the proposed work will provide the basis for determining

  2. No effect of the plant growth regulator, chlormequat, on boar fertility

    DEFF Research Database (Denmark)

    Sørensen, M.T.; Poulsen, Mette Erecius; Leffers, H.

    2009-01-01

    levels (three treatment groups), i.e. 0 mg CCC/kg BW per day (Control), 0.025 mg CCC/kg BW per day and 0.05 mg CCC/kg BW per day. Eight mother sows per treatment group were used in the experiment From the day of insemination, the mother sows received the experimental diets. The piglets were weaned at 4...... intake. The fraction of oocytes developing to more than the one-cell stage at day 5 after IVF was not (P=0.88) detrimentally affected by chlormequat intake. Chlormequat intake did not detrimentally affect the fraction of gilts being pregnant after one insemination (P=0.65) or the number of Embryos...

  3. Specific functions of the Rep and Rep׳ proteins of porcine circovirus during copy-release and rolling-circle DNA replication.

    Science.gov (United States)

    Cheung, Andrew K

    2015-07-01

    The roles of two porcine circovirus replication initiator proteins, Rep and Rep׳, in generating copy-release and rolling-circle DNA replication intermediates were determined. Rep uses the supercoiled closed-circular genome (ccc) to initiate leading-strand synthesis (identical to copy-release replication) and generates the single-stranded circular (ssc) genome from the displaced DNA strand. In the process, a minus-genome primer (MGP) necessary for complementary-strand synthesis, from ssc to ccc, is synthesized. Rep׳ cleaves the growing nascent-strand to regenerate the parent ccc molecule. In the process, a Rep׳-DNA hybrid containing the right palindromic sequence (at the origin of DNA replication) is generated. Analysis of the virus particle showed that it is composed of four components: ssc, MGP, capsid protein and a novel Rep-related protein (designated Protein-3). Copyright © 2015. Published by Elsevier Inc.

  4. Carlsberg Circular Community: when a company and its suppliers join forces to implement eco-innovation

    DEFF Research Database (Denmark)

    Niero, Monia; Boas, S.H.; Olsen, Stig Irving

    2014-01-01

    Carlsberg, the fourth largest global brewer in the world, and a selection of global suppliers have created the Carlsberg Circular Community (CCC), a cooperation platform aiming at rethinking the design and production of traditional packaging material. The ambition of the CCC is to develop products...... that are optimized for recycling and reuse, while retaining their quality and their value. CCC will contribute to reduce the reliance on raw materials, involve consumers and customers, as well as create new types of cooperation among partners to generate resource efficient products. Both Carlsberg and its suppliers...... are familiar with the Life Cycle Assessment (LCA) methodology and have successfully integrated it in product development and improvement. However, being inspired by the eco-efficiency principle, LCA aims to reduce the negative environmental footprint of human activities by optimizing product system...

  5. International Business Students’ Cross-Cultural Competence Development

    Directory of Open Access Journals (Sweden)

    Natalie S. Mikhaylov

    2014-12-01

    Full Text Available This study explores the role of educational programs in promoting students’ cross-cultural competence (CCC development in international business education. Using constructivist grounded theory methodology (GTM, a comparative analysis of four extensive case studies was conducted within four schools, all of which offer international management education in English for local and international students. This study examines institutional contributions to an environment that supports students’ CCC development. A typology model consisting of four educational approaches to students’ CCC development is presented based on student experiences. The study provides recommendations regarding the steps that higher educational institutions (HEIs can take to promote educational environments that support cross-cultural exchange, cultural knowledge creation, and individual and organizational cross-cultural competence development.

  6. Primary clear cell carcinoma of parotid gland: Case report and review of literature.

    Science.gov (United States)

    Rodríguez, Marta Saldaña; Reija, Maria Fe García; Rodilla, Irene González

    2013-01-01

    Clear cell carcinoma (CCC) is a rare low-grade carcinoma that represents only 1% to 2% of all salivary glands tumors. The finding of a clear cell tumor in a parotid gland involves the necessity of differential diagnosis between primary clear cell parotid tumors and metastases, mainly from kidney. The biological behavior is not very aggressive and development, which is very slow, is usually asymptomatic and indeed, the tumor often reaches considerable dimensions before being diagnosed. The treatment of choice is the surgical excision. There are rare cases of local recurrence and distant metastases. The aim of this article is to report a primary CCC in the parotid gland that microscopically closely resembled a metastatic CCC of renal origin, making microscopic differentiation difficult.

  7. A robust bayesian estimate of the concordance correlation coefficient.

    Science.gov (United States)

    Feng, Dai; Baumgartner, Richard; Svetnik, Vladimir

    2015-01-01

    A need for assessment of agreement arises in many situations including statistical biomarker qualification or assay or method validation. Concordance correlation coefficient (CCC) is one of the most popular scaled indices reported in evaluation of agreement. Robust methods for CCC estimation currently present an important statistical challenge. Here, we propose a novel Bayesian method of robust estimation of CCC based on multivariate Student's t-distribution and compare it with its alternatives. Furthermore, we extend the method to practically relevant settings, enabling incorporation of confounding covariates and replications. The superiority of the new approach is demonstrated using simulation as well as real datasets from biomarker application in electroencephalography (EEG). This biomarker is relevant in neuroscience for development of treatments for insomnia.

  8. Faithful teleportation with partially entangled states

    International Nuclear Information System (INIS)

    Gour, Gilad

    2004-01-01

    We write explicitly a general protocol for faithful teleportation of a d-state particle (qudit) via a partially entangled pair of (pure) n-state particles. The classical communication cost (CCC) of the protocol is log 2 (nd) bits, and it is implemented by a projective measurement performed by Alice, and a unitary operator performed by Bob (after receiving from Alice the measurement result). We prove the optimality of our protocol by a comparison with the concentrate and teleport strategy. We also show that if d>n/2, or if there is no residual entanglement left after the faithful teleportation, the CCC of any protocol is at least log 2 (nd) bits. Furthermore, we find a lower bound on the CCC in the process transforming one bipartite state to another by means of local operation and classical communication

  9. Potential role of mTORC2 as a therapeutic target in clear cell carcinoma of the ovary.

    Science.gov (United States)

    Hisamatsu, Takeshi; Mabuchi, Seiji; Matsumoto, Yuri; Kawano, Mahiru; Sasano, Tomoyuki; Takahashi, Ryoko; Sawada, Kenjiro; Ito, Kimihiko; Kurachi, Hirohisa; Schilder, Russell J; Testa, Joseph R; Kimura, Tadashi

    2013-07-01

    The goal of this study was to examine the role of mTOR complex 2 (mTORC2) as a therapeutic target in ovarian clear cell carcinoma (CCC), which is regarded as an aggressive, chemoresistant histologic subtype. Using tissue microarrays of 98 primary ovarian cancers [52 CCCs and 46 serous adenocarcinomas (SAC)], activation of mTORC2 was assessed by immunohistochemistry. Then, the growth-inhibitory effect of mTORC2-targeting therapy, as well as the role of mTORC2 signaling as a mechanism for acquired resistance to the mTOR complex 1 (mTORC1) inhibitor RAD001 in ovarian CCC, were examined using two pairs of RAD001-sensitive parental (RMG2 and HAC2) and RAD001-resistant CCC cell lines (RMG2-RR and HAC2-RR). mTORC2 was more frequently activated in CCCs than in SACs (71.2% vs. 45.7%). Simultaneous inhibition of mTORC1 and mTORC2 by AZD8055 markedly inhibited the proliferation of both RAD001-sensitive and -resistant cells in vitro. Treatment with RAD001 induced mTORC2-mediated AKT activation in RAD001-sensitive CCC cells. Moreover, increased activation of mTORC2-AKT signaling was observed in RAD001-resistant CCC cells compared with the respective parental cells. Inhibition of mTORC2 during RAD001 treatment enhanced the antitumor effect of RAD001 and prevented CCC cells from acquiring resistance to RAD001. In conclusion, mTORC2 is frequently activated, and can be a promising therapeutic target, in ovarian CCCs. Moreover, mTORC2-targeted therapy may be efficacious in a first-line setting as well as for second-line treatment of recurrent disease developing after RAD001-treatment.

  10. The study of diagnostic efficacy of MR spectroscopy in prostate cancer

    International Nuclear Information System (INIS)

    Ye Jintang; Guo Xuemei; Wang Xiaoying; Li Feiyu; Jiang Xuexiang

    2009-01-01

    Objective: To evaluate the diagnostic efficacy of MRS in prostate cancer based on sextant localization. Methods: There were 110 patients, 54 patients with pathologically confirmed prostate cancer and 56 patients confirmed non-prostate cancer proved by ultrasound guided systemic biopsy. The (choline + creatine) / citrate (CC/C) value in each voxel and ratio of positive voxel (PVR) in sextant localization were measured. The ROC analysis was used to evaluate the diagnostic efficacy of CC/C in single voxel and PVR in sextant localization. Results: There are 1673 and 2426 voxel in prostate cancer and non-prostate cancer respectively. The median of CC/C in cancer sextants was 2.137; the median of CC/C in noncancer sextants was 0.600. The difference of these two groups was statistically significant (Z = -41.7, P < 0.01). The diagnostic sensitivity was 81.4% (1362/1673), the specificity was 83.1% (2018/2426), and the accuracy was 82.4% [(1362 + 2018)/4099] for prostatic cancer with the cutoff point 0.911 of the CC/C value. The median of PVR in cancer sextants and noncancer sextants were 1 and 0 respectively, the difference of PVR was statistically significant ( Z =-11.7, P < 0.01). The diagnostic sensitivity was 77.5% (148/191), the specificity was 76.9% (247/321), and the accuracy was 77.1%[(148 + 247)/512] for prostatic cancer with the cutoff point 0.519 of the PVR. Conclusion: Detecting the cutoff point of the CC/C value in single voxel and the PVR in sextant localization may be valuable in the diagnosis of prostate cancer. (authors)

  11. Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner.

    Directory of Open Access Journals (Sweden)

    Josef Köck

    Full Text Available Persistence of hepatitis B virus (HBV infection requires covalently closed circular (cccDNA formation and amplification, which can occur via intracellular recycling of the viral polymerase-linked relaxed circular (rc DNA genomes present in virions. Here we reveal a fundamental difference between HBV and the related duck hepatitis B virus (DHBV in the recycling mechanism. Direct comparison of HBV and DHBV cccDNA amplification in cross-species transfection experiments showed that, in the same human cell background, DHBV but not HBV rcDNA converts efficiently into cccDNA. By characterizing the distinct forms of HBV and DHBV rcDNA accumulating in the cells we find that nuclear import, complete versus partial release from the capsid and complete versus partial removal of the covalently bound polymerase contribute to limiting HBV cccDNA formation; particularly, we identify genome region-selectively opened nuclear capsids as a putative novel HBV uncoating intermediate. However, the presence in the nucleus of around 40% of completely uncoated rcDNA that lacks most if not all of the covalently bound protein strongly suggests a major block further downstream that operates in the HBV but not DHBV recycling pathway. In summary, our results uncover an unexpected contribution of the virus to cccDNA formation that might help to better understand the persistence of HBV infection. Moreover, efficient DHBV cccDNA formation in human hepatoma cells should greatly facilitate experimental identification, and possibly inhibition, of the human cell factors involved in the process.

  12. Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission.

    Science.gov (United States)

    Shi, Xiaohong; Wang, Xuefei; Xu, Xixi; Feng, Yongliang; Li, Shuzhen; Feng, Shuying; Wang, Bo; Wang, Suping

    2017-12-01

    This study determined the effect of hepatitis B virus (HBV) replication in peripheral blood mononuclear cell (PBMC) from HBsAg-positive mothers on HBV intrauterine transmission. A total of 150 HBsAg-positive mothers and their neonates were recruited in this study. Within 24 h after birth, HBV serological markers, serum HBV DNA, PBMC HBV relaxed circular DNA (rcDNA), and covalently closed circular DNA (cccDNA) were measured in the HBsAg-positive mothers and their neonates before passive-active immune prophylaxis. The relationship between HBV replication in PBMC and HBV intrauterine transmission was examined through Chisquare test and logistic regression. The rate of HBV intrauterine transmission was 8.00% (12/150) in the 150 neonates born to HBsAg-positive mothers. The positivities of PBMC HBV rcDNA and cccDNA in the HBsAg-positive mothers were 36.67% (55/150) and 10% (15/150), respectively. Maternal PBMC HBV cccDNA was a risk factor of HBV intrauterine transmission (OR = 6.003, 95% CI: 1.249-28.855). Maternal serum HBeAg was a risk factor of PBMC HBV rcDNA (OR = 3.896, 95% CI: 1.929-7.876) and PBMC HBV cccDNA (OR = 3.74, 95% CI: 1.186-11.793) in the HBsAg-positive mothers. Administration of hepatitis B immune globulin was a protective factor of PBMC HBV cccDNA (OR = 0.312, 95%CI: 0.102-0.954) during pregnancy. The positivity of PBMC HBV rcDNA was related to that of cccDNA in the HBsAg-positive mothers (χ 2 = 5.087, P = 0.024). This study suggests that PBMC is a reservoir of HBV and an extrahepatic site for virus replication and plays a critical role in HBV intrauterine transmission.

  13. Continuous Curvilinear Capsulorhexis Training and Non-Rhexis Related Vitreous Loss: The Specificity of Virtual Reality Simulator Surgical Training (An American Ophthalmological Society Thesis).

    Science.gov (United States)

    McCannel, Colin A

    2017-08-01

    To assess the specificity of simulation-based virtual reality ophthalmic cataract surgery training on the Eyesi ophthalmic virtual reality surgical simulator, and test the hypothesis that microsurgical motor learning is highly specific. Retrospective educational interventional case series. The rates of vitreous loss and retained lens material, and vitreous loss and retained lens material associated with an errant continuous curvilinear capsulorhexis (CCC) were assessed among 1037 consecutive cataract surgeries performed during four consecutive academic years at a teaching hospital. The data were grouped by Eyesi use and capsulorhexis intensive training curriculum (CITC) completion. The main intervention was the completion of the CITC on the Eyesi. In the Eyesi simulator experience-based stratification, the vitreous loss rate was similar in each group (chi square p=0.95) and was not preceded by an errant CCC in 86.2% for "CITC done at least once", 57.1% for "CITC not done, but some Eyesi use", and 48.9% for "none" training groups (p=4×10-5). Retained lens material overall and occurring among the errant CCC cases was similar among training groups (p=0.82 and p=0.71, respectively). Eyesi capsulorhexis training was not associated with lower vitreous loss rates overall. However, non-errant CCC associated vitreous loss was higher among those who underwent Eyesi capsulorhexis training. Training focused on the CCC portion of cataract surgery may not reduce vitreous loss unassociated with an errant CCC. It is likely that surgical training is highly specific to the task being trained. Residents may need to be trained for all surgical steps with adequate intensity to minimize overall complication rates.

  14. Congenital Cutaneous Candidiasis: Prompt Systemic Treatment Is Associated With Improved Outcomes in Neonates.

    Science.gov (United States)

    Kaufman, David A; Coggins, Sarah A; Zanelli, Santina A; Weitkamp, Jörn-Hendrik

    2017-05-15

    Congenital cutaneous candidiasis (CCC) is a challenging diagnosis due to various rash presentations. Inadequate early treatment is associated with high rates of dissemination and death. The effects of early diagnosis, dermatologic presentation, and antifungal treatment on outcomes are lacking. CCC cases were reviewed from 2 academic neonatal intensive care units (NICUs) from 2004 to 2015. We defined CCC as a diffuse rash involving the body, extremities, face or scalp, and/or funisitis, presenting in the first week (≤7 days), with identification of Candida species from skin or mucous membrane cultures, and/or by culture or staining of the placenta or umbilical cord. CCC occurred in 0.1% of all NICU admissions (21 of 19 303) and 0.6% of infants <1000 grams birth weight. Median gestational age of CCC infants was 26 3/7 (range, 23 0/7-40 4/7) weeks. Skin findings were commonly present on the day of birth [median (range): 0 (0-6) days], appearing most frequently as a desquamating, maculopapular, papulopustular, and/or erythematous diffuse rash. When systemic antifungal therapy was started empirically at the time of rash presentation and continued for a median (interquartile range) of 14 (14-15) days, all patients survived and none developed dissemination. Delaying systemic treatment, exclusive use of nystatin, and treating for <10 days was associated with Candida bloodstream dissemination. CCC is an invasive infection that presents as a diffuse rash in preterm and term infants. Prompt systemic antifungal treatment at the time of skin presentation for ≥14 days prevents dissemination and Candida-related mortality. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

  15. An analysis of content in comprehensive cancer control plans that address chronic hepatitis B and C virus infections as major risk factors for liver cancer.

    Science.gov (United States)

    Momin, Behnoosh; Richardson, Lisa

    2012-08-01

    Chronic hepatitis B and hepatitis C virus (HBV and HCV) infections are among the leading causes of preventable death worldwide. Chronic viral hepatitis is the cause of most primary liver cancer, which is the third leading cause of cancer deaths globally and the ninth leading cause of cancer deaths in the United States. The extent to which comprehensive cancer control (CCC) programs in states, tribal governments and organizations, territories, and Pacific Island jurisdictions address chronic hepatitis B and/or hepatitis C infections as risk factors for liver cancer or recommend interventions for liver cancer prevention in their CCC plans remains unknown. We searched CCC plans for this information using the search tool at http://www.cdc.gov/cancer/ncccp/ to access the content of plans for this information. A combination of key search terms including "liver cancer", "hepatitis", "chronic alcohol", and "alcohol abuse" were used to identify potential content regarding liver cancer risk factors and prevention. Relevant content was abstracted for further review and classification. Of 66 (Although CDC funds 65 programs, one of the Pacific Island Jurisdiction grantees is the Federated States of Micronesia (FSM). This national program supports four FSM states, each of which submits a cancer plan to CDC for a total of 69 plans. During this time period, 66 plans were available on the website.) CCC plans, 27% (n = 18) addressed liver cancer using the above-mentioned search terms. In the 23 plans that addressed HBV and/or HCV, there were 25 goals, objectives, strategies, and outcomes aimed at reducing the incidence or prevalence of HBV and/or HCV infection. While nearly a third of CCC programs identify at least one goal, objective, strategy, outcome, or prevention program to reduce cancer burden in their CCC plans, few plans discuss specific actions needed to reduce the burden of liver cancer.

  16. Competency champions in the clinical competency committee: a successful strategy to implement milestone evaluations and competency coaching.

    Science.gov (United States)

    Ketteler, Erika R; Auyang, Edward D; Beard, Kathy E; McBride, Erica L; McKee, Rohini; Russell, John C; Szoka, Nova L; Nelson, M Timothy

    2014-01-01

    To create a clinical competency committee (CCC) that (1) centers on the competency-based milestones, (2) is simple to implement, (3) creates competency expertise, and (4) guides remediation and coaching of residents who are not progressing in milestone performance evaluations. We created a CCC that meets monthly and at each meeting reviews a resident class for milestone performance, a competency (by a faculty competency champion), a resident rotation service, and any other resident or issue of concern. University surgical residency program. The CCC members include the program director, associate program directors, director of surgical curriculum, competency champions, departmental chair, 2 at-large faculty members, and the administrative chief residents. Seven residents were placed on remediation (later renamed as coaching) during the academic year after falling behind on milestone progression in one or more competencies. An additional 4 residents voluntarily placed themselves on remediation for medical knowledge after receiving in-training examination scores that the residents (not the CCC membership) considered substandard. All but 2 of the remediated/coached residents successfully completed all area milestone performance but some chose to stay on the medical knowledge competency strategy. Monthly meetings of the CCC make milestone evaluation less burdensome. In addition, the expectations of the residents are clearer and more tangible. "Competency champions" who are familiar with the milestones allow effective coaching strategies and documentation of clear performance improvements in competencies for successful completion of residency training. Residents who do not reach appropriate milestone performance can then be placed in remediation for more formal performance evaluation. The function of our CCC has also allowed us opportunity to evaluate the required rotations to ensure that they offer experiences that help residents achieve competency performance necessary

  17. Analysis of hepatitis B virus intrahepatic covalently closed circular DNA and serum viral markers in treatment-naive patients with acute and chronic HBV infection.

    Directory of Open Access Journals (Sweden)

    Weijie Li

    Full Text Available BACKGROUND: This study aimed to investigate the relationships of intrahepatic cccDNA with serum HBsAg and with HBV DNA in treatment-naive patients throughout acute and chronic HBV infection. METHODS: A total of 120 patients who had a liver biopsy were enrolled, including 19 with acute hepatitis B (AHB, and 101 patients with chronic HBV infection (CHB of whom were 10 in immune-tolerant (IT phase, 59 in immune-clearance (IC phase, 8 in low-replicative (LR phase, and 24 in HBeAg-negative hepatitis (ENH phase. Intrahepatic cccDNA, serum HBsAg and serum HBV DNA levels were comparatively analyzed. RESULTS: The median intrahepatic cccDNA levels were 0.18 4.80, 3.81, 0.22 and 0.97 copies/cell for patients with AHB, CHB-IT, CHB-IC, CHB-LR, and CHB-ENH, respectively. In AHB patients, intrahepatic cccDNA was positively correlated with serum HBsAg (r = 0.665, P = 0.003, as well as serum HBV DNA (r = 0.536, P = 0.022. In CHB patients, intrahepatic cccDNA was positively correlated with serum HBsAg in the IC phase (r = 0.392, P = 0.005, and with serum HBV DNA in the IC phase (r = 0.301, P = 0.036 and ENH phase (r = 0.588, P = 0.013. HBV replicative efficiency, defined as the ratio of serum HBV DNA to intrahepatic cccDNA, was obviously lower in AHB and CHB-LR patients than in CHB-IT, CHB-IC and CHB-ENH patients (0.70 and 0.53 vs. 1.12, 1.09 and 0.99, P<0.001, values were logarithmic transformed for analysis. In CHB-IC patients, HBV replicative efficiency was positively correlated with histological activity index of liver inflammation (r = 0.308, P = 0.009. CONCLUSION: Serum HBsAg and HBV DNA levels may reflect the amount of active intrahepatic cccDNA in treatment-naive AHB and CHB-IC patients. Reduced intrahepatic cccDNA and HBV replicative efficiency may imply effective immune control of HBV infection.

  18. Uracil DNA glycosylase counteracts APOBEC3G-induced hypermutation of hepatitis B viral genomes: excision repair of covalently closed circular DNA.

    Directory of Open Access Journals (Sweden)

    Kouichi Kitamura

    Full Text Available The covalently closed circular DNA (cccDNA of the hepatitis B virus (HBV plays an essential role in chronic hepatitis. The cellular repair system is proposed to convert cytoplasmic nucleocapsid (NC DNA (partially double-stranded DNA into cccDNA in the nucleus. Recently, antiviral cytidine deaminases, AID/APOBEC proteins, were shown to generate uracil residues in the NC-DNA through deamination, resulting in cytidine-to-uracil (C-to-U hypermutation of the viral genome. We investigated whether uracil residues in hepadnavirus DNA were excised by uracil-DNA glycosylase (UNG, a host factor for base excision repair (BER. When UNG activity was inhibited by the expression of the UNG inhibitory protein (UGI, hypermutation of NC-DNA induced by either APOBEC3G or interferon treatment was enhanced in a human hepatocyte cell line. To assess the effect of UNG on the cccDNA viral intermediate, we used the duck HBV (DHBV replication model. Sequence analyses of DHBV DNAs showed that cccDNA accumulated G-to-A or C-to-T mutations in APOBEC3G-expressing cells, and this was extensively enhanced by UNG inhibition. The cccDNA hypermutation generated many premature stop codons in the P gene. UNG inhibition also enhanced the APOBEC3G-mediated suppression of viral replication, including reduction of NC-DNA, pre-C mRNA, and secreted viral particle-associated DNA in prolonged culture. Enhancement of APOBEC3G-mediated suppression by UNG inhibition was not observed when the catalytic site of APOBEC3G was mutated. Transfection experiments of recloned cccDNAs revealed that the combination of UNG inhibition and APOBEC3G expression reduced the replication ability of cccDNA. Taken together, these data indicate that UNG excises uracil residues from the viral genome during or after cccDNA formation in the nucleus and imply that BER pathway activities decrease the antiviral effect of APOBEC3-mediated hypermutation.

  19. Cytokine production but lack of proliferation in peripheral blood mononuclear cells from chronic Chagas' disease cardiomyopathy patients in response to T. cruzi ribosomal P proteins.

    Directory of Open Access Journals (Sweden)

    Silvia A Longhi

    2014-06-01

    Full Text Available BACKGROUND: Trypanosoma cruzi ribosomal P proteins, P2β and P0, induce high levels of antibodies in patients with chronic Chagas' disease Cardiomyopathy (CCC. It is well known that these antibodies alter the beating rate of cardiomyocytes and provoke apoptosis by their interaction with β1-adrenergic and M2-muscarinic cardiac receptors. Based on these findings, we decided to study the cellular immune response to these proteins in CCC patients compared to non-infected individuals. METHODOLOGY/PRINCIPAL FINDINGS: We evaluated proliferation, presence of surface activation markers and cytokine production in peripheral blood mononuclear cells (PBMC stimulated with P2β, the C-terminal portion of P0 (CP0 proteins and T. cruzi lysate from CCC patients predominantly infected with TcVI lineage. PBMC from CCC patients cultured with P2β or CP0 proteins, failed to proliferate and express CD25 and HLA-DR on T cell populations. However, multiplex cytokine assays showed that these antigens triggered higher secretion of IL-10, TNF-α and GM-CSF by PBMC as well as both CD4+ and CD8+ T cells subsets of CCC subjects. Upon T. cruzi lysate stimulation, PBMC from CCC patients not only proliferated but also became activated within the context of Th1 response. Interestingly, T. cruzi lysate was also able to induce the secretion of GM-CSF by CD4+ or CD8+ T cells. CONCLUSIONS/SIGNIFICANCE: Our results showed that although the lack of PBMC proliferation in CCC patients in response to ribosomal P proteins, the detection of IL-10, TNF-α and GM-CSF suggests that specific T cells could have both immunoregulatory and pro-inflammatory potential, which might modulate the immune response in Chagas' disease. Furthermore, it was possible to demonstrate for the first time that GM-CSF was produced by PBMC of CCC patients in response not only to recombinant ribosomal P proteins but also to parasite lysate, suggesting the value of this cytokine to evaluate T cells responses in T

  20. Realce Tardio miocárdico por Ressonância Magnética Cardíaca pode identificar risco para Taquicardia Ventricular na Cardiopatia Chagásica Crônica

    OpenAIRE

    Ronaldo Peixoto de Mello; Gilberto Szarf; Paulo Roberto Schvartzman; Edson Minoru Nakano; Mariano Martinez Espinosa; Denis Szejnfeld; Verônica Fernandes; João A. C. Lima; Claudio Cirenza; Angelo A.V. De Paola

    2012-01-01

    FUNDAMENTO: Testes invasivos e não invasivos têm sido usados para identificar risco para Taquicardia Ventricular (TV) em pacientes com Cardiopatia Chagásica Crônica (CCC). Ressonância Magnética Cardíaca (RMC) pela técnica do Realce Tardio (RT) pode ser útil para selecionar pacientes com disfunção ventricular global ou segmentar, com alto grau de fibrose e maior risco para TV clínica. OBJETIVO: Melhorar a identificação de elementos preditivos de TV em pacientes com CCC. MÉTODO: Quarenta e um p...

  1. HBV-Specific shRNA is Capable of Reducing the Formation of Hepatitis B Virus Covalently Closed Circular DNA, but has No Effect on Established Covalently Closed Circular DNA in vitro

    OpenAIRE

    Starkey, Jason L.; Chiari, Estelle F.; Isom, Harriet C.

    2009-01-01

    Hepatitis B virus (HBV) covalently closed circular DNA (CCC DNA) is the source of HBV transcripts and persistence in chronically infected patients. The novel aspect of this study was to determine the effect of RNA interference (RNAi) on HBV CCC DNA when administered prior to establishment of HBV replication or during chronic HBV infection. HBV replication was initiated in HepG2 cells by transduction with HBV baculovirus. Subculture of HBV expressing HepG2 cells at 10 days post-transduction ge...

  2. Purification of a synthetic pterocarpanquinone by countercurrent chromatography

    International Nuclear Information System (INIS)

    Costa, Fernanda das Neves; Silva, Alcides Jose M. da; Domingos, Jorge L. de Oliveira; Costa, Paulo Roberto R.; Leitao, Gilda G.; Daher Netto, Chaquip

    2012-01-01

    Countercurrent chromatography (CCC) was employed as a useful, fast and economic alternative to conventional chromatography techniques for the purification of a synthetic pterocarpanquinone, LQB-118. The separation was performed in a two-step CCC with the solvent system hexanechloroform- methanol-water 2:1.5:5:2 in both steps. Traditional purification of these reaction products by silica gel column chromatography demanded a large amount of solvent and time, besides allowing the irreversible adsorption of the compound in the column. The use of 1 H NMR for the calculation of KD of target compound is proposed as an alternative for HPLC measurements. (author)

  3. Ki-67 as a prognostic marker in mantle cell lymphoma-consensus guidelines of the pathology panel of the European MCL Network

    DEFF Research Database (Denmark)

    Klapper, W.; Hoster, E.; Determann, O.

    2009-01-01

    powerful prognostic biomarker. The pathology panel of the European MCL Network evaluated methods to assess the Ki-67 index including stringent counting, digital image analysis, and estimation by eyeballing. Counting of 2 x 500 lymphoma cells is the gold standard to assess the Ki-67 index since this value...... has been shown to predict survival in prospective randomized trials of the European MCL Network. Estimation by eyeballing and digital image analysis showed a poor concordance with the gold standard (concordance correlation coefficients [CCC] between 0.29 and 0.61 for eyeballing and CCC of 0.24 and 0...

  4. LA FORMACIÓN UNIVERSITARIA Y EL EJERCICIO PROFESIONAL DE LOS EGRESADOS DE LAS CARRERAS DE COMPLEMENTACIÓN CURRICULAR DEL ÁREA DE EDUCACIÓN DE LA UNTREF.

    OpenAIRE

    Liliana, Mandolesi; Roberto, Canabal Ariel; Liliana, Varano

    2013-01-01

    Como todas las carreras de grado, las de complementación curricular (C.C.C) del área de Educación de la UNTREF, tienen como objetivo la formación de egresados para desempeñarse en las actividades y campo ocupacional vinculados a las respectivas titulaciones. En particular, al ser C.C.C. su especificidad es que la mayoría de sus alumnos han transitado por experiencias laborales en el ámbito educativo. Además, es requisito para incorporarse a estas carreras el poseer un título...

  5. Ab initio predictions on the rotational spectra of carbon-chain carbene molecules

    Science.gov (United States)

    Maluendes, S. A.; McLean, A. D.; Loew, G. H. (Principal Investigator)

    1992-01-01

    We predict rotational constants for the carbon-chain molecules H2C=(C=)nC, n=3-8, using ab initio computations, observed values for the earlier members in the series, H2CCC and H2CCCC with n=1 and 2, and empirical geometry corrections derived from comparison of computation and experiment on related molecules. H2CCC and H2CCCC have already been observed by radioastronomy; higher members in the series, because of their large dipole moments, which we have calculated, are candidates for astronomical searches. Our predictions can guide searches and assist in both astronomical and laboratory detection.

  6. The algebraic method of the scattering inverse problem solution under untraditional statements

    CERN Document Server

    Popushnoj, M N

    2001-01-01

    The algebraic method of the scattering inverse problem solution under untraditional statements is proposed consistently in this review, in the framework of which some quantum theory od scattering charged particles problem were researched afterwards. The inverse problem of scattering theory of charged particles on the complex plane of the Coulomb coupling constant (CCC) is considered. A procedure of interaction potential restoration is established for the case when the energy, orbital moment quadrate and CCC are linearly dependent. The relation between one-parametric problems of the potential scattering of charged particles is investigated

  7. A Comparison of Math Cover, Copy, Compare Intervention Procedures for Children with Autism Spectrum Disorder.

    Science.gov (United States)

    Morton, Reeva C; Gadke, Daniel L

    2018-03-01

    Cover, Copy, Compare (CCC) and Copy, Cover, Compare (MCCC) procedures are effective interventions for improving math fluency. However, there is a gap in literature exploring the use of these interventions for children with autism spectrum disorders (ASD). The purpose of the current study was to compare the use of CCC and MCCC for children with ASD using a multi-component single-case experimental design. The results showed no notable difference between the interventions. Implications and limitations, particularly surrounding experimental control, are discussed in detail.

  8. Calculation of electron-helium scattering

    International Nuclear Information System (INIS)

    Fursa, D.V.; Bray, I.

    1994-11-01

    We present the Convergent Close-Coupling (CCC) theory for the calculation of electron-helium scattering. We demonstrate its applicability at a range of projectile energies of 1.5 to 500 eV to scattering from the ground state to n ≤3 states. Excellent agreement with experiment is obtained with the available differential, integrated, ionization, and total cross sections, as well as with the electron-impact coherence parameters up to and including the 3 3 D state excitation. Comparison with other theories demonstrates that the CCC theory is the only general reliable method for the calculation of electron helium scattering. (authors). 66 refs., 2 tabs., 24 figs

  9. A Bayesian Framework for Estimating the Concordance Correlation Coefficient Using Skew-elliptical Distributions.

    Science.gov (United States)

    Feng, Dai; Baumgartner, Richard; Svetnik, Vladimir

    2018-04-05

    The concordance correlation coefficient (CCC) is a widely used scaled index in the study of agreement. In this article, we propose estimating the CCC by a unified Bayesian framework that can (1) accommodate symmetric or asymmetric and light- or heavy-tailed data; (2) select model from several candidates; and (3) address other issues frequently encountered in practice such as confounding covariates and missing data. The performance of the proposal was studied and demonstrated using simulated as well as real-life biomarker data from a clinical study of an insomnia drug. The implementation of the proposal is accessible through a package in the Comprehensive R Archive Network.

  10. Corporate Social Responsibility in the Garment Industry. The Case of the Clean Clothes Campaign and Developing States

    OpenAIRE

    Wawrzyniak, Tomasz

    2017-01-01

    The aim of the article is to investigate the Clean Clothes Campaign (CCC) organization and its efforts to alleviate the poor situation of workers in developing states and to promote the idea of Corporate Social Responsibility. It starts with a brief example of two such developing countries, Bangladesh and Cambodia, data for which has been drawn from Eurostat, Trading Economics, and the CIA’s World Factbook. It then moves to its main focus, that is, the description of the structure of the CCC,...

  11. Biological effects and oxidative stress responses in Arabidopsis thaliana following exposure to uranium and copper

    Energy Technology Data Exchange (ETDEWEB)

    Horemans, N.; Saenen, E.; Vandenhove, H.; Vanhoudt, N.; Wannijn, J.; Nauts, R. [Belgian Nuclear Research Centre SCK-CEN (Belgium); Vangronsveld, J.; Cuypers, A. [Hasselt University (Belgium)

    2014-07-01

    Since organisms are almost always exposed to multiple stressors, it is important to investigate the toxicity effects in plants in a multiple stressor context to provide a more realistic estimate of environmental risks. Therefore, we evaluated the toxicity of U and Cu individually and in combination. Arabidopsis thaliana plants were exposed during 3 days to 25 μM U, 2.5 μM Cu or 12.5 μM U + 1.25 μM Cu at pH 7.5. The concentrations of U and Cu administered to the plants were the derived EC30 values for plant growth reduction based on the single-dose response curves. When plants were exposed to U or Cu, this resulted in an increased metal concentration in both roots and shoots as compared to the control plants. The increased Cu content of the plant, led to a significant decrease in leaf and root growth, while U exposure did not affect plant growth. By exposing plants to both metals, it seems that Cu interferes with the translocation of U from the roots to the leaves. In addition, U interferes with the Cu uptake, since less Cu was found in the roots than expected. This can probably be explained by the fact that U causes a shift in the Cu speciation in our medium. As such, the percentage of the bioavailable fractions of Cu decreased, while the percentage Cu-EDTA (i.e. non-available fraction) increased. No effects on plant growth were observed by exposing plants to U+Cu. Exposing plants to heavy metals can lead to an increased production of reactive oxygen species (ROS). After U or Cu exposure, the transcript levels of different ROS-producing enzymes (NADPH oxidases and lipoxygenases (LOX)) were up-regulated in the roots. Furthermore, exposing plants to U+Cu resulted in a 20-fold increase in the expression of LOX1 as compared to the single stressor conditions. This possibly indicates an enhanced ROS production. In addition, the increased expression of LOX1 can also indicate an increased production of oxylipins, important molecules in inter-organ signalling. In the

  12. Umbelliferae Familyasından Bazı Önemli Kültür Türlerinin Isparta Ekolojik Koşullarında Tarımsal ve Teknolojik Özelliklerinin Belirlenmesi

    Directory of Open Access Journals (Sweden)

    Sevil KESKİN

    2016-04-01

    Full Text Available Anason (Pimpinella anisum L., dereotu (Anethum graveolens L., kimyon (Cuminum cyminum L., kişniş (Coriandrum sativum L., rezene (Foeniculum vulgare Mill. dünyada ve ülkemizde kültürü yapılan çok değerli tıbbi ve aromatik bitkilerdir. Bu araştırmada; anason, kimyon, kişniş, rezene ve dereotu türlerine ait çeşitlerin ve populasyonların Isparta ekolojik koşullarında bazı tarımsal ve teknolojik özelliklerinin belirlenmesi, uçucu yağ, sabit yağ ve petroselinik asit kaynağı olarak değerlendirme olanaklarının araştırılması amaçlanmıştır. Tarla ve laboratuvar araştırmalarından elde edilen sonuçlara göre, en yüksek tohum verimi anasonda “Yeşilova” populasyonundan (47.01 kg/da, dereotunda “Akşehir” populasyonundan (77.75 kg/da, kimyonda “Egebir09” çeşidinden (97.00 kg/da, kişnişte “Erbaa” çeşidinden (82.85 kg/da ve rezenede “Denizli” populasyonundan (63.66 kg/da elde edilmiştir. En yüksek uçucu yağ oranı anasonda “Burdur” populasyonunda (%3.60, dereotunda “Burdur” populasyonunda (%3.73, kimyonda “Türkmen09” çeşidinde (%2.13, kişnişte “Gamze” çeşidinde (%0.47 ve rezenede “Burdur” populasyonunda (%3.13 tespit edilmiştir. En önemli ana uçucu yağ bileşeni anasonda trans-anetol (%95.56-95.88, dereotunda D-karvon (%37.87-67.76, kimyonda a-thujenal (%30.90-42.52, kişnişte linalool (%81.85-88.94 ve rezenede trans-anetol (%79.67-89.13 olarak bulunmuştur. En yüksek sabit yağ oranı anasonda “Burdur” populasyonunda (%30.17, dereotunda “Burdur” populasyonunda (%21.24, kimyonda “Egebir09” çeşidinde (%29.03, kişnişte “Erbaa” çeşidinde (%25.42 ve rezenede “Denizli” populasyonunda (%23.67 belirlenmiştir. En yüksek petroselinik asit oranı ise anasonda “Çardak” populasyonunda (%63.37, dereotunda “Burdur” populasyonunda (%87.28, kimyonda “Türkmen09” çeşidinde (%60.18, kişnişte “Erbaa” çeşidinde (%79.89 ve

  13. Local and Macroscopic Properties of Stripe Ordered Conductors

    International Nuclear Information System (INIS)

    Kivelson, Steven A.

    2011-01-01

    The tendency of many strongly correlated electron systems to form locally inhomogeneous structures is now well established. This introduces new emergent length scales into the electronic structure. In the research supported by this grant, we examined some of the consequences of this new length scale. In particular, we showed that in the limit where the inhomogeneous structures are strong and of certain forms (we considered a checkerboard lattice as a concrete example), it is possible to examine how strong repulsive interactions give rise to a substantial superconducting pairing scale. Interestingly, even though the interactions are purely repulsive, there is a crossover as a function of U, much like the one that occurs in the attractive Hubbard model, from a region with relatively strong pairing, but with a small Tc due to the small superfluid stiffness, to a region with in which Tc tends to zero as the pairing scale vanishes. However, in contrast to the attractive model, in the repulsive checkerboard model, the pairing scale vanishes at a finite critical value of U=Uc, where the superfluid stiffness is largest, and drops with decreasing U. The other point of contrast is that the superconducting state has d-wave symmetry for the repulsive model.

  14. Fractional statistics and quantum scaling properties of the integrable Penson-Kolb-Hubbard chain

    Science.gov (United States)

    Vitoriano, Carlindo; Coutinho-Filho, M. D.

    2010-09-01

    We investigate the ground-state and low-temperature properties of the integrable version of the Penson-Kolb-Hubbard chain. The model obeys fractional statistical properties, which give rise to fractional elementary excitations and manifest differently in the four regions of the phase diagram U/t versus n , where U is the Coulomb coupling, t is the correlated hopping amplitude, and n is the particle density. In fact, we can find local pair formation, fractionalization of the average occupation number per orbital k , or U - and n -dependent average electric charge per orbital k . We also study the scaling behavior near the U -driven quantum phase transitions and characterize their universality classes. Finally, it is shown that in the regime of parameters where local pair formation is energetically more favorable, the ground state exhibits power-law superconductivity; we also stress that above half filling the pair-hopping term stabilizes local Cooper pairs in the repulsive- U regime for U1=-2tcos(nπ/2) .

  15. rRNA fragmentation induced by a yeast killer toxin.

    Science.gov (United States)

    Kast, Alene; Klassen, Roland; Meinhardt, Friedhelm

    2014-02-01

    Virus like dsDNA elements (VLE) in yeast were previously shown to encode the killer toxins PaT and zymocin, which target distinct tRNA species via specific anticodon nuclease (ACNase) activities. Here, we characterize a third member of the VLE-encoded toxins, PiT from Pichia inositovora, and identify PiOrf4 as the cytotoxic subunit by conditional expression in Saccharomyces cerevisiae. In contrast to the tRNA targeting toxins, however, neither a change of the wobble uridine modification status by introduction of elp3 or trm9 mutations nor tRNA overexpression rescued from PiOrf4 toxicity. Consistent with a distinct RNA target, expression of PiOrf4 causes specific fragmentation of the 25S and 18S rRNA. A stable cleavage product comprising the first ∼ 130 nucleotides of the 18S rRNA was purified and characterized by linker ligation and subsequent reverse transcription; 3'-termini were mapped to nucleotide 131 and 132 of the 18S rRNA sequence, a region showing some similarity to the anticodon loop of tRNA(Glu)(UUC), the zymocin target. PiOrf4 residues Glu9 and His214, corresponding to catalytic sites Glu9 and His209 in the ACNase subunit of zymocin are essential for in vivo toxicity and rRNA fragmentation, raising the possibility of functionally conserved RNase modules in both proteins. © 2013 John Wiley & Sons Ltd.

  16. Final Phase II report : QuickSite(R) investigation, Everest, Kansas.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M. (Environmental Research)

    2003-11-01

    The Commodity Credit Corporation (CCC), an agency of the U.S. Department of Agriculture (USDA), operated grain storage facilities at two different locations at Everest, Kansas (Figure 1.1). One facility (referred to in this report as the Everest facility) was at the western edge of the city of Everest. The CCC/USDA operated this facility from 1950 until the early 1970s. The second facility (referred to in this report as Everest East) was about 0.5 mi northeast of the town. The CCC/USDA operated this facility from 1954 until the early 1970s. While these two former CCC/USDA grain storage facilities were in operation, commercial grain fumigants containing carbon tetrachloride were in common use by the CCC/USDA and the private grain storage industry to preserve grain. In 1997, the Kansas Department of Health and Environment (KDHE) sampled several domestic drinking water and nondrinking water wells in the Everest area. The KDHE sampling was part of the CCC/USDA Private Well Sampling Program, which was initiated to determine whether carbon tetrachloride was present in domestic wells near former CCC/USDA grain storage facilities in Kansas. All of the sampled domestic drinking water wells were located outside the Everest city boundaries. As a result of this sampling, carbon tetrachloride contamination was identified at a single domestic drinking water well (the Nigh well; DW06) approximately 3/8 mi northwest of the former Everest CCC/USDA grain storage facility. The CCC/USDA subsequently connected the Nigh residence to the Everest municipal water system. As a result of the detection of carbon tetrachloride in this well, the KDHE conducted preliminary investigations to further evaluate the existence of contamination and its potential effect on public health and the environment. The KDHE concluded that carbon tetrachloride in groundwater at Everest might, in part, be linked to historical use of carbon tetrachloride-based grain fumigants at the former CCC/USDA facilities. For

  17. ÇİMENTO ENJEKSİYONLARINDA KULLANILAN KATKI MALZEMELERİNİN REOLOJİK ÖZELLİKLERE ETKİLERİNİN ARAŞTIRILMASI

    Directory of Open Access Journals (Sweden)

    Özcan TAN

    2004-02-01

    Full Text Available Bu çalışmada farklı oranlardaki bentonit (B, uçucu kül (UK ve silis dumanı (SD ile birlikte hazırlanan enjeksiyon karışımlarının reolojik özellikleri araştırılmıştır. Deneyler için Taguchi Yöntemine göre 3 parametreli 4 seviyeli L16 deney tasarım tablosu seçilmiştir. Enjeksiyon karışımlarının hazırlanmasında, kullanılan katı ağırlığının % 0, % 0.5, % 1 ve % 3'ü oranlarında bentonit, % 10, % 20, % 30 ve % 40'ı oranlarında uçucu kül ve % 0, % 5, % 10 ve % 20'i oranlarında silis dumanı kullanılmıştır. Hazırlanan enjeksiyon karışımları için laboratuarda çökelme ve Marsh Hunisi deneyleri yapılmıştır. Deneyler su/katı (S/K 1.25 için yapılmış olup deney sonuçları Taguchi Yöntemine göre ayrı ayrı değerlendirilmiştir. Yapılan değerlendirmeler sonucunda; Akma süresi ve çökelme miktarı üzerinde en etkili parametrenin silis dumanı olduğu belirlenmiştir. Enjeksiyon karışımlarının incelenen özellikleri için optimum karışım oranları Taguchi Yöntemi ile belirlenmiş ve bu oranlar için doğrulama deneyleri yapılmıştır.

  18. Bazı Biyolojik Preparatların Sitophilus granarius (Coleoptera: Curculionidae Erginlerine Etkileri

    Directory of Open Access Journals (Sweden)

    Tuğba AYYILDIZ

    2017-09-01

    Full Text Available Bu çalışmada, Entomopatojen funguslardan Biocatch, Nibortem (Verticillium lecani, BMAUM-M3-003 (Metharizum anisopliae ile okaliptus ve zencefil bitkilerinden elde edilen uçucu yağların ve bir bitkisel ekstrakt preparatı olan Nibedicine EC (Azadiractin’in buğdaylarda oldukça önemli zarara neden olan Sitophilus granarius (Coleoptera: Curculionidae erginlerine karşı laboratuar koşullarında etkinlikleri denenmiştir. 10x10x8 cm boyutlarında ağızları tül ile yapıştırılmış olan plastik kaplarda ve 25±1 °C sıcaklık, %60±5 nem oranlarında ve 16:8 saat ışıklandırma süresine ayarlı iklim odasında yetiştirilen S. granarius erginleri üzerine Biocatch, Nibortem (Verticillium lecanii entomopatojen funguslardan 1x109  cfu/mL, BMAUM-M3-003 (Metharizum anisopliae 1x108  cfu/mL dozunda, Nibedicine EC (Azadirachtin 3000 ppm dozunda, uçucu yağlar ise %1 (1 l/100 l dozunda uygulanmıştır. Çalışma sonucunda elde edilen verilere göre BMAUM-M3-003 kodlu entomopatojen fungus (M. anisopliae, S. granarius’u zamana bağlı olarak en fazla etkileyen etmen olmuştur. Yapılan değerlendirmeler sonucunda kullanılan preparatların 21 gün sonunda etkileri incelendiğinde, zencefilin %89.47, diğerlerinin ise %100 ölüm oranına sahip olduğu saptanmıştır.

  19. Kastamonu Sarmısağının (Allium sativum L. Kimyasal Bileşiminin Belirlenmesi Üzerine Araştırma

    Directory of Open Access Journals (Sweden)

    Nevzat Artık

    2015-02-01

    Full Text Available Sarımsak (Allium sativum L. antimikrobiyal etkisi ve çeşni verme özelliği nedeni ile üretilmektedir. Ülkemizde Kastamonu yöresinde yetiştirilen sarımsak, bileşimi ve etken maddesi nedeniyle tüm Avrupa ülkelerinde tanınmaktadır. Sarmısağın bileşim unsurları konusunda yeterli bilgi mevcut değildir. Bu araştırmada Kastamonu ilinden sağlanan 40 farklı sarımsak örneğinde fiziksel, kimyasal özellikler ve Hunter renk değerleri saptanmıştır. Sarımsak örneklerinde şeker analizleri enzimatik yöntemle belirlenmiştir. Sarımsak örneklerinde toplam şeker miktarı %33.41-49.67 sınırları arasında değişim göstermektedir. Toplam şekeri oluşturan şekerlerden D-glukoz %1.169-2.03, D-fruktoz %2.872-10.394 ve sakaroz %22.67-41.0 düzeyindedir. Sarımsak örneklerinde sarmısağın antimikrobiyal etki ve çeşni açısından önemli bileşiği olan uçucu organik sülfür bileşikleri, allil sülfür [(CH3H52S] cinsinden %0.097-0.214 arasında bulunmuştur. Kastamonu sarımsak örnekleri vitamin, mineral ve uçucu sülfür bileşikleri açısından zengin bir gıda maddesidir.

  20. 75 FR 76921 - Tobacco Transition Payment Program; Tobacco Transition Assessments

    Science.gov (United States)

    2010-12-10

    ... adjustments published on the FSA website both in the fall of 2009 and this year. CCC will, however, continue... authority for part 1463 to refer to the United States Code citation for FETRA, rather than the public law citation. Executive Order 12866 This technical amendment did not require Office of Management and Budget...

  1. Single Assignment C (SAC): High Productivity meets High Performance

    NARCIS (Netherlands)

    Grelck, C.; Zsók, V.; Horváth, Z.; Plasmeijer, R.

    2012-01-01

    We present the ins and outs of the purely functional, data parallel programming language SaC (Single Assignment C). SaC defines state- and side-effect-free semantics on top of a syntax resembling that of imperative languages like C/C++/C# or Java: functional programming with curly brackets. In

  2. The "Russian roulette" of soccer? : Perceived control and anxiety in a major tournament penalty shootout

    NARCIS (Netherlands)

    Jordet, Geir; T Elferink-Gemser, Marije; Lemmink, Koen A. P. M.; Visscher, Chris

    2006-01-01

    Kicks from the penalty mark (official term for the "penalty shootout") are regularly featured in major soccer tournaments to determine the outcome of tied games. Based on the contingency-competence-control (CCC) model (Weisz & Stipek, 1982), this study provides an examination of the control beliefs

  3. Effect of phytohormones on growth and ion accumulation of wheat ...

    African Journals Online (AJOL)

    ABA), benzyladenine (BA) and cycocel (CCC) on growth and ion accumulation of three spring wheat cultivars, cv. Wafaq-2001, cv. Inqulab-91, and cv. SAARC-1 under salinity stress. Seeds of all the cultivars were treated prior to sowing with ABA ...

  4. 7 CFR 1421.9 - Basic loan rates.

    Science.gov (United States)

    2010-01-01

    ..., oats, grain sorghum, rice, peanuts, soybean, canola, flaxseed, mustard seed, rapeseed, safflower, sunflower seed, dry peas, lentils, chickpeas, crambe, sesame seed, wool, mohair and other crops designated... by CCC to reflect grade, type, quality, location and other factors applicable to the commodity and as...

  5. 78 FR 42486 - Notice of New Recreation Fee; Federal Lands Recreation Enhancement Act

    Science.gov (United States)

    2013-07-16

    .../living room combination, and a fully-equipped kitchen. It can accommodate up to five people. The Portal... shower), and a small kitchen/dining room combination. It can accommodate up to four people. Both.... People wanting to rent the Portal CCC House or Portal Bunkhouse would need to do so through the National...

  6. "Climate Cost of Cultivation": A New Crop Index Method to Quantify Farmers' Cost of Climate Change Exemplified in Rural India

    NARCIS (Netherlands)

    N. Jangle (Nihar); M. Mehra (Mamta); D.M. Dror (David)

    2016-01-01

    textabstractWe model the impact of agricultural droughts with a new multi-parameter index (using both climatic and non-climatic parameters) and propose a new risk transfer solution for crop insurance, called Climate Cost of Cultivation (CCC). We used 1979/80 to 2012/13 data relevant for wheat in

  7. From the Ear to the Brain: Advances in Understanding Auditory Function, Technology and Spoken Language Development

    Science.gov (United States)

    Santos-Sacchi, Joseph; Allen, Jont B.; Dorman, Michael; Bergeson-Dana, Tonya R.

    2012-01-01

    These are the proceedings of 2012 AG Bell Research Symposium, presented July 1, 2012, as part of the AG Bell 2012 Convention. The session was moderated by Tamala S. Bradham, Ph.D., CCC-A. The papers presented at the proceedings are the following: (1) The Queens of Audition; (2) Speech Perception and Hearing Loss; (3) The Restoration of Speech…

  8. 7 CFR 1493.40 - Application for payment guarantee.

    Science.gov (United States)

    2010-01-01

    ... and allowances, if any. (11) Port value (includes upward loading tolerance, if any). (12) Guaranteed..., contract loading tolerance and, if necessary, a request for CCC to reserve coverage up to the maximum quantity permitted by the contract loading tolerance. (9) Unit sales price of the commodity, or a mechanism...

  9. 7 CFR 1493.430 - Application for a payment guarantee.

    Science.gov (United States)

    2010-01-01

    ... (includes upward loading tolerance, if any); (12) Guaranteed value; (13) Guarantee fee; (14) The term length... (including packaging, if any); (8) Mean quantity, contract loading tolerance and, if the exporter chooses, a request for CCC to reserve coverage up to the maximum quantity permitted by the contract loading tolerance...

  10. Dissolved carbon and nitrogen leaching following variable logging-debris retention and competing-vegetation control in Douglas-fir plantations of western Oregon and Washington

    Science.gov (United States)

    Robert A. Slesak; Stephen H. Schoenholtz; Timothy B. Harrington; Brian D. Strahm

    2009-01-01

    We examined the effect of logging-debris retention and competing-vegetation control (CCC, initial or annual applications) on dissolved organic carbon (DOC), dissolved organic nitrogen, and nitrate-N leaching to determine the relative potential of these practices to contribute to soil C and N loss at two contrasting sites. Annual CVC resulted in higher soil water...

  11. Effect of health education on oral health-related quality of life among ...

    African Journals Online (AJOL)

    Objective: To evaluate the effect of health education on quality of life of persons living with HIV/AIDS. Design: Quasi-Experimental study. Setting: Comprehensive Care Centres (CCC), at Kenyatta National Hospital and Mbagathi District Hospital. Subject: One hundred and ninety five persons living with HIV/AIDS attending ...

  12. Strategies to control tree vigour and optimise fruit production in 'Conference' pears

    NARCIS (Netherlands)

    Maas, F.M.

    2008-01-01

    The ban on the use of chlormequat (CCC) in pear orchards in 2001 forced Dutch pear growers to look for alternative methods to control tree vigour and stimulate flower bud development and fruit production. Root pruning and trunk notching have become the major growth retarding methods. In addition to

  13. Carbon carry capacity and carbon sequestration potential in China based on an integrated analysis of mature forest biomass.

    Science.gov (United States)

    Liu, YingChun; Yu, GuiRui; Wang, QiuFeng; Zhang, YangJian; Xu, ZeHong

    2014-12-01

    Forests play an important role in acting as a carbon sink of terrestrial ecosystem. Although global forests have huge carbon carrying capacity (CCC) and carbon sequestration potential (CSP), there were few quantification reports on Chinese forests. We collected and compiled a forest biomass dataset of China, a total of 5841 sites, based on forest inventory and literature search results. From the dataset we extracted 338 sites with forests aged over 80 years, a threshold for defining mature forest, to establish the mature forest biomass dataset. After analyzing the spatial pattern of the carbon density of Chinese mature forests and its controlling factors, we used carbon density of mature forests as the reference level, and conservatively estimated the CCC of the forests in China by interpolation methods of Regression Kriging, Inverse Distance Weighted and Partial Thin Plate Smoothing Spline. Combining with the sixth National Forest Resources Inventory, we also estimated the forest CSP. The results revealed positive relationships between carbon density of mature forests and temperature, precipitation and stand age, and the horizontal and elevational patterns of carbon density of mature forests can be well predicted by temperature and precipitation. The total CCC and CSP of the existing forests are 19.87 and 13.86 Pg C, respectively. Subtropical forests would have more CCC and CSP than other biomes. Consequently, relying on forests to uptake carbon by decreasing disturbance on forests would be an alternative approach for mitigating greenhouse gas concentration effects besides afforestation and reforestation.

  14. Expression and Purification of Coat Protein of Citrus Tristeza Virus ...

    African Journals Online (AJOL)

    5' TCA ACG TGT GTT AAA TTT CCC AAG C 3') and cloned into TOPO vector and transformed to TOP10 E. coli competent cell. Six colonies of TOP10 E. coli were selected and checked for the appropriate insertion of cp gene with PCR.

  15. 7 CFR 1434.19 - Settlement.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Settlement. 1434.19 Section 1434.19 Agriculture... FOR HONEY § 1434.19 Settlement. The value of the settlement of loans shall be made by CCC on the... commodity: (1) If the value of the collateral at settlement is less than the amount due, the producer shall...

  16. The Tudor domain protein Spindlin1 is involved in intrinsic antiviral defense against incoming hepatitis B Virus and herpes simplex virus type 1.

    Directory of Open Access Journals (Sweden)

    Aurélie Ducroux

    2014-09-01

    Full Text Available Hepatitis B virus infection (HBV is a major risk factor for the development of hepatocellular carcinoma. HBV replicates from a covalently closed circular DNA (cccDNA that remains as an episome within the nucleus of infected cells and serves as a template for the transcription of HBV RNAs. The regulatory protein HBx has been shown to be essential for cccDNA transcription in the context of infection. Here we identified Spindlin1, a cellular Tudor-domain protein, as an HBx interacting partner. We further demonstrated that Spindlin1 is recruited to the cccDNA and inhibits its transcription in the context of infection. Spindlin1 knockdown induced an increase in HBV transcription and in histone H4K4 trimethylation at the cccDNA, suggesting that Spindlin1 impacts on epigenetic regulation. Spindlin1-induced transcriptional inhibition was greater for the HBV virus deficient for the expression of HBx than for the HBV WT virus, suggesting that HBx counteracts Spindlin1 repression. Importantly, we showed that the repressive role of Spindlin1 is not limited to HBV transcription but also extends to other DNA virus that replicate within the nucleus such as Herpes Simplex Virus type 1 (HSV-1. Taken together our results identify Spindlin1 as a critical component of the intrinsic antiviral defense and shed new light on the function of HBx in HBV infection.

  17. Enacting Change through Action Learning: Mobilizing and Managing Power and Emotion

    Science.gov (United States)

    Conklin, James; Cohen-Schneider, Rochelle; Linkewich, Beth; Legault, Emma

    2012-01-01

    This paper reports on a study of how action learning facilitates the movement of knowledge between social contexts. The study involved a community organization that provides educational services related to aphasia and members of a complex continuing care (CCC) practice that received training from the agency. People with aphasia (PWA) (a disability…

  18. ISSN 1727-3781

    African Journals Online (AJOL)

    allyd

    This contribution is based on research undertaken by the author in partial fulfilment of the ... Senior Lecturer, Department of Law, Faculty of. Humanities ..... approach in R v Big M Drug Mart Ltd 1985 50 CCC (3d) 1 (SCC) which was followed by.

  19. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

    NARCIS (Netherlands)

    Phillips-Krawczak, Christine A.; Singla, Amika; Starokadomskyy, Petro; Deng, Zhihui; Osborne, Douglas G.; Li, Haiying; Dick, Christopher J.; Gomez, Timothy S.; Koenecke, Megan; Zhang, Jin-San; Dai, Haiming; Sifuentes-Dominguez, Luis F.; Geng, Linda N.; Kaufmann, Scott H.; Hein, Marco Y.; Wallis, Mathew; McGaughran, Julie; Gecz, Jozef; De Sluis, Bart van; Billadeau, Daniel D.; Burstein, Ezra

    2015-01-01

    COMMD1 deficiency results in defective copper homeostasis, but the mechanism for this has remained elusive. Here we report that COMMD1 is directly linked to early endosomes through its interaction with a protein complex containing CCDC22, CCDC93, and C16orf62. This COMMD/CCDC22/CCDC93 (CCC) complex

  20. Summary of operations and performance of the Murdock site restoration project in June 2005-December 2006.

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, L. M.; Environmental Science Division

    2007-05-31

    This document summarizes the performance of the groundwater and surface water restoration systems installed by the Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) at the former CCC/USDA grain storage facility in Murdock, Nebraska, during the initial period of systems operation, from June 2005 through December 2006. In the Murdock project, several innovative technologies are being used to remove carbon tetrachloride contamination from a shallow aquifer underlying the town, as well as from water naturally discharged to the surface at the headwaters of a small creek (a tributary to Pawnee Creek) north of the town (Figure 1.1). The restoration activities at Murdock are being conducted by the CCC/USDA as a non-time-critical removal action under the regulatory authority and supervision of the U.S. Environmental Protection Agency (EPA), Region VII. Argonne National Laboratory assisted the CCC/USDA by providing technical oversight for the restoration effort and facilities during this review period. Included in this report are the results of all sampling and monitoring activities performed in accord with the EPA-approved Monitoring Plan for this site (Argonne 2006), as well as additional investigative activities conducted during the review period. This document presents overviews of the treatment facilities (Section 2) and site operations and activities (Section 3), then describes the groundwater, surface water, vegetation, and atmospheric monitoring results (Section 4) and modifications and costs during the review period (Section 5). Section 6 summarizes the initial period of operation.

  1. Enhancing Cross-Cultural Competence in Multicultural Teacher Education: Transformation in Global Learning

    Science.gov (United States)

    Seeberg, Vilma; Minick, Theresa

    2012-01-01

    Teacher education needs to engage teacher candidates in developing cross-cultural competence so that they may be able to transmit global learning to their future students. This study theorizes cross-cultural competence (CCC) from the perspectives of multicultural and global education. During a four-year project at a mid-western US university,…

  2. Fuel Economy Impacts of Manual, Conventional Cruise Control, and Predictive Eco-Cruise Control Driving

    Directory of Open Access Journals (Sweden)

    Sangjun Park

    2013-09-01

    Full Text Available The paper presents the results of a field experiment that was designed to compare manual driving, conventional cruise control (CCC driving, and Eco-cruise control (ECC driving with regard to fuel economy. The field experiment was conducted on five test vehicles along a section of Interstate 81 that was comprised of ±4% uphill and downhill grade sections. Using an Onboard Diagnostic II reader, instantaneous fuel consumption rates and other driving parameters were collected with and without the CCC system enabled. The collected data were compared with regard to fuel economy, throttle control, and travel time. The results demonstrate that CCC enhances vehicle fuel economy by 3.3 percent on average relative to manual driving, however this difference was not found to be statistically significant at a 5 percent significance level. The results demonstrate that CCC driving is more efficient on downhill versus uphill sections. In addition, the study demonstrates that an ECC system can produce fuel savings ranging between 8 and 16 percent with increases in travel times ranging between 3 and 6 percent. These benefits appear to be largest for heavier vehicles (SUVs.

  3. Career Construction with a Gay Client: A Case Study

    Science.gov (United States)

    Maree, Jacobus Gideon

    2014-01-01

    This article reports on the value of career construction counselling (CCC) with a gay person. The participant was selected purposively, with the selection criteria calling for a mid-career woman who had sought career counselling. The intervention involved administration of the "Career Construction Interview" (CCI) and the creation of a…

  4. 7 CFR 1416.204 - Application process.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Application process. 1416.204 Section 1416.204 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT... PROGRAMS Livestock Indemnity Program II § 1416.204 Application process. (a) Applicants must submit to CCC a...

  5. 7 CFR 1416.103 - Application process.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Application process. 1416.103 Section 1416.103 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT... PROGRAMS Livestock Compensation Program § 1416.103 Application process. (a) Applicants must submit to CCC...

  6. 7 CFR 1493.4 - Criteria for country allocations.

    Science.gov (United States)

    2010-01-01

    ... export credit guarantees would provide for the development, expansion or maintenance of the market for particular U.S. agricultural commodities in the importing country; (b) Financial and economic ability of the importing country to adequately service CCC guaranteed debt; (c) Financial status of participating banks in...

  7. Effects of simultaneously elevated temperature and CO2 levels on Nicotiana benthamiana and its infection by different positive-sense RNA viruses are cumulative and virus type-specific.

    Science.gov (United States)

    Del Toro, Francisco J; Rakhshandehroo, Farshad; Larruy, Beatriz; Aguilar, Emmanuel; Tenllado, Francisco; Canto, Tomás

    2017-11-01

    We have studied how simultaneously elevated temperature and CO 2 levels [climate change-related conditions (CCC) of 30°C, 970 parts-per-million (ppm) of CO 2 vs. standard conditions (SC) of 25°C, ~ 405ppm CO 2 ] affect physiochemical properties of Nicotiana benthamiana leaves, and also its infection by several positive-sense RNA viruses. In previous works we had studied effects of elevated temperature, CO 2 levels separately. Under CCC, leaves of healthy plants almost doubled their area relative to SC but contained less protein/unit-of-area, similarly to what we had found under conditions of elevated CO 2 alone. CCC also affected the sizes/numbers of different foliar cell types differently. Under CCC, infection outcomes in titers and symptoms were virus type-specific, broadly similar to those observed under elevated temperature alone. Under either condition, infections did not significantly alter the protein content of leaf discs. Therefore, effects of elevated temperature and CO 2 combined on properties of the pathosystems studied were overall cumulative. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. 7 CFR 1423.2 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1423.2 Section 1423.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... Administration. On behalf of CCC, the Farm Service Agency (FSA) will administer this part under the supervision...

  9. Integrating Compassionate, Collaborative Care (the "Triple C") Into Health Professional Education to Advance the Triple Aim of Health Care.

    Science.gov (United States)

    Lown, Beth A; McIntosh, Sharrie; Gaines, Martha E; McGuinn, Kathy; Hatem, David S

    2016-03-01

    Empathy and compassion provide an important foundation for effective collaboration in health care. Compassion (the recognition of and response to the distress and suffering of others) should be consistently offered by health care professionals to patients, families, staff, and one another. However, compassion without collaboration may result in uncoordinated care, while collaboration without compassion may result in technically correct but depersonalized care that fails to meet the unique emotional and psychosocial needs of all involved. Providing compassionate, collaborative care (CCC) is critical to achieving the "triple aim" of improving patients' health and experiences of care while reducing costs. Yet, values and skills related to CCC (or the "Triple C") are not routinely taught, modeled, and assessed across the continuum of learning and practice. To change this paradigm, an interprofessional group of experts recently recommended approaches and a framework for integrating CCC into health professional education and postgraduate training as well as clinical care. In this Perspective, the authors describe how the Triple C framework can be integrated and enhance existing competency standards to advance CCC across the learning and practice continuum. They also discuss strategies for partnering with patients and families to improve health professional education and health care design and delivery through quality improvement projects. They emphasize that compassion and collaboration are important sources of professional, patient, and family satisfaction as well as critical aspects of professionalism and person-centered, relationship-based high-quality care.

  10. Infant behaviors are predictive of functional somatic symptoms at ages 5-7 years

    DEFF Research Database (Denmark)

    Rask, Charlotte Ulrikka; Ørnbøl, Eva; Olsen, Else Marie

    2013-01-01

    OBJECTIVE: To investigate infancy predictors of impairing functional somatic symptoms (FSS) at child ages 5-7 years with a focus on problems with feeding, sleep, and tactile reactivity. STUDY DESIGN: This study is part of a longitudinal birth cohort study, Copenhagen Child Cohort CCC2000. Child h...

  11. 7 CFR 1410.10 - Restoration of wetlands.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Restoration of wetlands. 1410.10 Section 1410.10... Restoration of wetlands. (a) An owner or operator who entered into a CRP contract on land that is suitable for restoration to wetlands or that was restored to wetlands while under such contract, may, if approved by CCC...

  12. The effect of different lung densities on the accuracy of various radiotherapy dose calculation methods: implications for tumour coverage

    DEFF Research Database (Denmark)

    Aarup, Lasse Rye; Nahum, Alan E; Zacharatou, Christina

    2009-01-01

    PURPOSE: To evaluate against Monte-Carlo the performance of various dose calculations algorithms regarding lung tumour coverage in stereotactic body radiotherapy (SBRT) conditions. MATERIALS AND METHODS: Dose distributions in virtual lung phantoms have been calculated using four commercial Treatm...... target dose, the AAA(Ecl) and CCC(OMP) algorithms appear to be adequate alternatives to MC....

  13. Low genetic diversity of the endangered Indian wild ass Equus ...

    Indian Academy of Sciences (India)

    DEVENDRA KHAIRE

    (Equus hemionus khur) belongs to an endangered wild species/subspecies of wild ... species of the Asiatic wild asses, E. hemionus and E. kiang, have been described on .... 57.9. Tseng et al. (2010). 5 -TCA CCC ACT AAA TCT CAA ATC C-3.

  14. An Evaluation of Copy Cover and Compare Spelling Intervention for an Elementary Student with Learning Disabilities: A Replication

    Science.gov (United States)

    Breach, Celena; McLaughlin, T. F.; Derby, K. Mark

    2016-01-01

    The purpose of this study was to increase the spelling performance for a 4th grade student with learning disabilities. The second objective was to replicate the document with the efficacy of Copy, Cover, and Compare (CCC) in spelling. The study was conducted in a resource room in a low socio-economic school in the Pacific Northwest. The skill…

  15. A sense of green

    NARCIS (Netherlands)

    Nigten, Anne

    2015-01-01

    This booklet is a short reflection on the workshop activities by the research group, Popular culture Sustainability and Innovation (PSI), of the Hanze University in Groningen for the CCC Reloaded: CREALAB project over the last one and half years. Based on a series of explorative workshops this

  16. Can the Children's Communication Checklist differentiate between children with autism, children with ADHD, and normal controls?

    NARCIS (Netherlands)

    Geurts, H.M.; Verte, S.; Osterlaan, J.; Roeyers, H; Hartman, C.A.; Mulder, Erik J.; Berckelaer-Onnes, I.A.; Sergeant, J.A.; van Berckelaer-Onnes, IA

    2004-01-01

    Background:  The Children's Communication Checklist (CCC; Bishop, 1998) is a questionnaire that was developed to measure pragmatic language use and may be completed by parents and teachers. Two studies are reported, which were designed to investigate: (1) whether children with Attention Deficit

  17. Role of plant growth regulators on oil yield and biodiesel production of linseed (linum usitatissimum l)

    International Nuclear Information System (INIS)

    Faizanullah, A.; Bano, A.; Nosheen, A.

    2010-01-01

    A field experiment was conducted to compare the effect of plant growth regulators (PGRs) viz. kinetin (K), chlorocholine chloride (CCC) and salicylic acid (SA) on seed yield, oil content and oil quality of Linseed (Linum usitatissimum L) cv. Chandni with a new perspective to biodiesel production. The growth regulators (10-6M) were applied as seed soaking for 10 h prior to cultivation. Kinetin significantly increased the number of capsules/plant, seed number/capsule, 1000 seed weight and total seed yield (kg/h). The growth regulators increased the seed oil content maximum being in kinetin and CCC treatments. Kinetin and CCC significantly decreased the oil acid value, free fatty acid content (% oleic acid) and increased the pH of oil. Nevertheless, SA significantly decreased the oil specific gravity and did not alter the pH. Only kinetin significantly increased the oil iodine value. The oil extracted from seeds of kinetin and CCC treated plants showed maximum conversion (% w/w) to methyl esters/biodiesel after transesterification. It can be inferred that PGRs can be utilized successfully for improving the biodiesel yield of linseed. (author)

  18. Purification of Active Myrosinase from Plants by Aqueous Two-Phase Counter-Current Chromatography

    Science.gov (United States)

    Wade, Kristina L.; Ito, Yoichiro; Ramarathnam, Aarthi; Holtzclaw, W. David; Fahey, Jed W.

    2014-01-01

    Introduction Myrosinase (thioglucoside glucohydrolase; E.C. 3.2.1.147), is a plant enzyme of increasing interest and importance to the biomedical community. Myrosinase catalyses the formation of isothiocyanates such as sulforaphane (frombroccoli) and 4-(α-l-rhamnopyranosyloxy)benzyl isothiocyanate (from moringa), which are potent inducers of the cytoprotective phase-2 response in humans, by hydrolysis of their abundant glucosinolate (β-thioglucoside N-hydroxysulphate) precursors. Objective To develop an aqueous two-phase counter-current chromatography (CCC) system for the rapid, three-step purification of catalytically active myrosinase. Methods A high-concentration potassium phosphate and polyethylene glycol biphasic aqueous two-phase system (ATPS) is used with a newly developed CCC configuration that utilises spiral-wound, flat-twisted tubing (with an ovoid cross-section). Results Making the initial crude plant extract directly in the ATPS and injecting only the lower phase permitted highly selective partitioning of the myrosinase complex before a short chromatography on a spiral disk CCC. Optimum phase retention and separation of myrosinase from other plant proteins afforded a 60-fold purification. Conclusion Catalytically active myrosinase is purified from 3-day broccoli sprouts, 7-day daikon sprouts, mustard seeds and the leaves of field-grown moringa trees, in a CCC system that is predictably scalable. PMID:25130502

  19. Purification of active myrosinase from plants by aqueous two-phase counter-current chromatography.

    Science.gov (United States)

    Wade, Kristina L; Ito, Yoichiro; Ramarathnam, Aarthi; Holtzclaw, W David; Fahey, Jed W

    2015-01-01

    Myrosinase (thioglucoside glucohydrolase; E.C. 3.2.1.147), is a plant enzyme of increasing interest and importance to the biomedical community. Myrosinase catalyses the formation of isothiocyanates such as sulforaphane (from broccoli) and 4-(α-l-rhamnopyranosyloxy)benzyl isothiocyanate (from moringa), which are potent inducers of the cytoprotective phase-2 response in humans, by hydrolysis of their abundant glucosinolate (β-thioglucoside N-hydroxysulphate) precursors. To develop an aqueous two-phase counter-current chromatography (CCC) system for the rapid, three-step purification of catalytically active myrosinase. A high-concentration potassium phosphate and polyethylene glycol biphasic aqueous two-phase system (ATPS) is used with a newly developed CCC configuration that utilises spiral-wound, flat-twisted tubing (with an ovoid cross-section). Making the initial crude plant extract directly in the ATPS and injecting only the lower phase permitted highly selective partitioning of the myrosinase complex before a short chromatography on a spiral disk CCC. Optimum phase retention and separation of myrosinase from other plant proteins afforded a 60-fold purification. Catalytically active myrosinase is purified from 3-day broccoli sprouts, 7-day daikon sprouts, mustard seeds and the leaves of field-grown moringa trees, in a CCC system that is predictably scalable. Copyright © 2014 John Wiley & Sons, Ltd.

  20. Countercurrent chromatography separation of saponins by skeleton type from Ampelozizyphus amazonicus for off-line ultra-high-performance liquid chromatography/high resolution accurate mass spectrometry analysis and characterisation.

    Science.gov (United States)

    de Souza Figueiredo, Fabiana; Celano, Rita; de Sousa Silva, Danila; das Neves Costa, Fernanda; Hewitson, Peter; Ignatova, Svetlana; Piccinelli, Anna Lisa; Rastrelli, Luca; Guimarães Leitão, Suzana; Guimarães Leitão, Gilda

    2017-01-20

    Ampelozizyphus amazonicus Ducke (Rhamnaceae), a medicinal plant used to prevent malaria, is a climbing shrub, native to the Amazonian region, with jujubogenin glycoside saponins as main compounds. The crude extract of this plant is too complex for any kind of structural identification, and HPLC separation was not sufficient to resolve this issue. Therefore, the aim of this work was to obtain saponin enriched fractions from the bark ethanol extract by countercurrent chromatography (CCC) for further isolation and identification/characterisation of the major saponins by HPLC and MS. The butanol extract was fractionated by CCC with hexane - ethyl acetate - butanol - ethanol - water (1:6:1:1:6; v/v) solvent system yielding 4 group fractions. The collected fractions were analysed by UHPLC-HRMS (ultra-high-performance liquid chromatography/high resolution accurate mass spectrometry) and MS n . Group 1 presented mainly oleane type saponins, and group 3 showed mainly jujubogenin glycosides, keto-dammarane type triterpene saponins and saponins with C 31 skeleton. Thus, CCC separated saponins from the butanol-rich extract by skeleton type. A further purification of group 3 by CCC (ethyl acetate - ethanol - water (1:0.2:1; v/v)) and HPLC-RI was performed in order to obtain these unusual aglycones in pure form. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. 7 CFR 1412.76 - Payments.

    Science.gov (United States)

    2010-01-01

    ... with the highest and lowest yields, using National Agricultural Statistics Service data to the extent..., after the end of the applicable marketing year for the covered commodity or peanuts. (a) CCC will make... national average market price received by producers during the 12-month marketing year for the covered...

  2. Miocárdio não compactado, Doença de Chagas e disfunção: relato de caso Miocardio no compactado, Enfermedad de Chagas y disfunción: caso clínico Noncompaction of the myocardium, Chagas' disease and dysfunction: a case report

    Directory of Open Access Journals (Sweden)

    Ronaldo Peixoto de Mello

    2010-07-01

    Full Text Available Relatamos a associação entre a cardiopatia associada ao miocárdio não compactado do ventrículo esquerdo (MNCVE à cardiopatia chagásica crônica (CCC em paciente com clínica de insuficiência cardíaca, acidente vascular cerebral isquêmico e arritmia cardíaca. As imagens típicas de MNCVE e CCC foram documentadas pela ressonância magnética cardíaca (RMC.Relatamos la asociación entre la cardiopatía asociada al miocardio no compactado del ventrículo izquierdo (MNCVI con la cardiopatía chagásica crónica (CCC en paciente con clínica de insuficiencia cardíaca, accidente vascular cerebral isquémico y arritmia cardíaca. Las imágenes típicas de MNCVI y CCC fueron documentadas por resonancia magnética cardíaca (RMC.We report the association between heart disease associated with noncompaction of the left ventricular myocardium (NCLVM and chronic Chagas' heart disease (CCHD in a patient with heart failure, ischemic stroke and cardiac arrhythmia. Images typical of NCLVM and CCHD were documented by cardiac magnetic resonance imaging (CMRI.

  3. Start of run2 physics at the Large Hadron Collider (LHC)

    CERN Multimedia

    Brice, Maximilien

    2015-01-01

    Images from the CERN Control Centre (CCC), where operators control the LHC, and from the control rooms of the ALICE, ATLAS, CMS and LHCb experiments, where operators control huge detectors that capture data from collisions between beams of protons in the LHC.

  4. 7 CFR 1434.8 - Containers and drums.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Containers and drums. 1434.8 Section 1434.8... REGULATIONS FOR HONEY § 1434.8 Containers and drums. (a)(1) To be eligible for assistance under this part, honey must be packed in: (i) CCC-approved, 5-gallon plastic containers; (ii) 5-gallon metal containers...

  5. 7 CFR 17.10 - Refunds and insurance.

    Science.gov (United States)

    2010-01-01

    ... credit the account of the participant or will refund local currency in accordance with paragraph (e) of... for financing, in whole or in part, the supplier shall refund in dollars such excess price or... against CCC for recovery of the amount refunded or set off. (e) Refund of local currency or reduction of...

  6. 7 CFR Exhibit B to Subpart A of... - Memorandum of Understanding and Blanket Commodity Lien Waiver

    Science.gov (United States)

    2010-01-01

    ... commodity with respect to which the loan or purchase is made. The word “subordinated” means that, in the... makes loans to farmers on the security of agricultural commodities that are eligible for price support under loan and purchase programs conducted by the Commodity Credit Corporation (CCC). FmHA or its...

  7. Effect of the growth retardant Cycocel® in controlling the growth of ...

    African Journals Online (AJOL)

    STORAGESEVER

    2010-07-19

    Jul 19, 2010 ... Hydroponic culture of Gladiolus tristis: Application of paclobutrazol for flowering and height control. Afr. J. Biotechnol. 7(3): 239-243. Ninnemann H, Zeevaart JAD, Kende H, Lang A (1964). The plant growth retardant CCC as an inhibitor of gibberellin biosynthesis in. Fusarium moniliforme. Planta (Bert.) ...

  8. LAI and chlorophyll estimation for a heterogeneous grassland using hyperspectral measurements

    NARCIS (Netherlands)

    Darvishzadeh, R.; Skidmore, A.K.; Schlerf, M.; Atzberger, C.; Corsi, F.; Cho, M.A.

    2008-01-01

    The study shows that leaf area index (LAI), leaf chlorophyll content (LCC) and canopy chlorophyll content (CCC) can be mapped in a heterogeneous Mediterranean grassland from canopy spectral reflectance measurements. Canopy spectral measurements were made in the field using a GER 3700

  9. Detection and Management of Adverse Drug Reactions Related to ...

    African Journals Online (AJOL)

    The objective of this study was to establish the detection, prevalence and management of various adverse drug reactions associated with antiretroviral drugs occurring in patients attending Comprehensive Care Centre (CCC) of Kiambu District Hospital. The study was a cross sectional survey where the patients included ...

  10. 76 FR 36512 - USDA Increases the Domestic Sugar Overall Allotment Quantity, Reassigns Domestic Cane Sugar...

    Science.gov (United States)

    2011-06-22

    ... imports. The OAQ was increased due to an increase in estimated sugar demand since the FY 2011 OAQ was... sugar imports, as required by law. Upon review of the domestic sugarcane processors' sugar marketing allocations relative to their FY 2011 expected raw sugar supplies, CCC determined that all sugarcane...

  11. 7 CFR 1205.513 - Collecting handlers and time of collection of the supplemental assessment.

    Science.gov (United States)

    2010-01-01

    ... with the Cotton Board. (i) Any person who exports cotton of that person's own production shall be the... advance, any payment, or any credit to the producer's account for the cotton. Supplemental assessments due... value of cotton. The producer's copy of the Cotton Producer's Note (Form CCC Cotton A) shall show...

  12. 7 CFR 1205.512 - Collecting handlers and time of collection of $1 per bale assessment.

    Science.gov (United States)

    2010-01-01

    ... consumes domestically or exports cotton of that person's own production shall be the collecting handler for... handler first makes any payment or any credit to the producer's account for the cotton. The handler shall... disbursement based on the Form A loan documents. The producer's copy of the Cotton Producer's Note (Form CCC...

  13. 7 CFR 1427.1208 - Payment.

    Science.gov (United States)

    2010-01-01

    ...) Exported by the exporter on the date that CCC determines is the date on which the cotton is shipped for... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COTTON Extra Long Staple (ELS) Cotton Competitiveness... weight of bagging and ties) determined under paragraph (b) of this section, of eligible ELS cotton bales...

  14. Hiperuricemia y progresión del compromiso cardiorrenal crónico

    Directory of Open Access Journals (Sweden)

    Manuel A Virú-Loza

    Full Text Available Con el objetivo de determinar si la hiperuricemia está asociada con la progresión del compromiso cardiorrenal crónico (CCC se realizó un estudio de cohorte retrospectiva que incluyó a 103 pacientes en quienes se definió CCC como presencia simultánea de enfermedad renal crónica (ERC y enfermedad cardiaca crónica (ECC. Se definió progresión de la ERC como la reducción del 50% de la tasa de filtración glomerular estimada por la ecuación MDRD-4. Se definió hiperuricemia como niveles de ácido úrico basal ≥ 7 mg/dL. Ninguna de las variables estudiadas demostró asociación con la progresión del CCC o la ECC. Las variables que mostraron ser factores independientes de progresión de la ERC fueron hiperuricemia basal (HR 4,41; IC 95%: 1,02-18,94 y PAS en el seguimiento (HR 1,05; IC 95%: 1,01-1,09. Se concluye que la hiperuricemia mostró ser un factor de riesgo independiente de progresión de ERC en pacientes con CCC.

  15. Design of real-time communication system for image recognition based colony picking instrument

    Science.gov (United States)

    Wang, Qun; Zhang, Rongfu; Yan, Hua; Wu, Huamin

    2017-11-01

    In order to aachieve autommated observatiion and pickinng of monocloonal colonies, an overall dessign and realizzation of real-time commmunication system based on High-throoughput monooclonal auto-piicking instrumment is propossed. The real-time commmunication system is commposed of PCC-PLC commuunication systtem and Centrral Control CComputer (CCC)-PLC communicatioon system. Bassed on RS232 synchronous serial communnication methood to develop a set of dedicated shoort-range commmunication prootocol betweenn the PC and PPLC. Furthermmore, the systemm uses SQL SSERVER database to rrealize the dataa interaction between PC andd CCC. Moreoover, the commmunication of CCC and PC, adopted Socket Ethernnet communicaation based on TCP/IP protoccol. TCP full-dduplex data cannnel to ensure real-time data eexchange as well as immprove system reliability andd security. We tested the commmunication syystem using sppecially develooped test software, thee test results show that the sysstem can realizze the communnication in an eefficient, safe aand stable way between PLC, PC andd CCC, keep thhe real-time conntrol to PLC annd colony inforrmation collecttion.

  16. The reproducibility of quantitative measurements in lumbar magnetic resonance imaging of children from the general population

    DEFF Research Database (Denmark)

    Masharawi, Y; Kjær, Per; Bendix, T

    2008-01-01

    --zygoappophyseal tranverse superior facet angles, sagittal VB, and disc wedging, lumbar lordosis, and sacral inclination. Statistical analysis included the concordance correlation coefficient (CCC), and Bland and Altman's limits of agreement (LOA). RESULTS: A total of 6160 measurements were analyzed. Good to excellent...... intratester reproducibility (0.75 lordosis, and sacral inclination (LOA: 11.22 degrees ; 12.34 degrees). VB and disc...

  17. Changes in users' mental models of Web search engines after ten ...

    African Journals Online (AJOL)

    Ward's Cluster analyses including the Pseudo T² Statistical analyses were used to determine the mental model clusters for the seventeen salient design features of Web search engines at each time point. The cubic clustering criterion (CCC) and the dendogram were conducted for each sample to help determine the number ...

  18. 76 FR 21318 - Notice of Funds Availability; Inviting Applications for the Quality Samples Program

    Science.gov (United States)

    2011-04-15

    ... to the final destination will not be eligible for reimbursement. CCC will not reimburse the costs... run in the destination country). QSP projects shall target foreign importers and audiences who: Have... proposal that incorporates requests for funding and recommendations for virtually all of the FAS marketing...

  19. 77 FR 24166 - Notice of Funds Availability; Inviting Applications for the Quality Samples Program

    Science.gov (United States)

    2012-04-23

    ... to the final destination will not be eligible for reimbursement. CCC will not reimburse the costs... run in the destination country). QSP projects shall target foreign importers and audiences who: Have... proposal that incorporates requests for funding and recommendations for virtually all of the FAS marketing...

  20. Monothiodibenzoylmethane: Structural and vibrational assignments

    DEFF Research Database (Denmark)

    Hansen, Bjarke Knud Vilster; Gorski, Alexander; Posokhov, Yevgen

    2007-01-01

    vibrational spectra were compared with theoretical transitions obtained with B3LYP/cc-pVTZ density functional theory (DFT). The results leave no doubt that the stable ground state configuration of TDBM corresponds to the intramolecularly hydrogen bonded enol form (e-CCC), and that the photoproduct corresponds...

  1. 2 September 2009 - H.S.H. Prince Albert II of Monaco (second from right) visiting CMS underground experimental area with, from left to right, Ambassador R. Fillon, Collaboration Spokesperson T. Virdee and CERN Director-General R. Heuer.

    CERN Multimedia

    Maximilien Brice

    2009-01-01

    Tirage 1-28:caverne expérimentale CMS avec le Porte-parole de la Collaboration T. Virdee Tirage 29-42:CCC avec le Chef du Département Faisceaux(BE) P. Collier et Département Faisceaux, groupe opérations, LHC Ingénieur Responsable L. Ponce.

  2. A comparative study of four major approaches to predicting ATES performance

    Science.gov (United States)

    Doughty, C.; Buscheck, T. A.; Bodvarsson, G. S.; Tsang, C. F.

    1982-09-01

    The International Energy Agency test problem involving Aquifer Thermal Energy Storage was solved using four approaches: the numerical model PF (formerly CCC), the simpler numerical model SFM, and two graphical characterization schemes. Each of the four techniques, with the advantages and disadvantages of each, are discussed.

  3. 7 CFR 792.3 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... debts and claims. The late payment interest rate shall be determined as of the date a debt becomes... debt owed the Government, or any agency thereof. FSA means the Farm Service Agency of the United States..., data file, or similar record of debts owed to FSA, CCC, or any other Government Agency with respect to...

  4. Genetic association study of NLRP1, CARD, and CASP1 inflammasome genes with chronic Chagas cardiomyopathy among Trypanosoma cruzi seropositive patients in Bolivia.

    Science.gov (United States)

    Clipman, Steven J; Henderson-Frost, Josephine; Fu, Katherine Y; Bern, Caryn; Flores, Jorge; Gilman, Robert H

    2018-01-01

    About 20-30% of people infected with Chagas disease present with chronic Chagas cardiomyopathy (CCC), the most serious and frequent manifestation of the disease, while others remain asymptomatic and often do not experience Chagas-specific mortality. It is not currently well understood what causes these differential disease outcomes, but a genetic predisposition within the host could play an important role. This study examined variants in the NLRP1, CARD, and CASP1 inflammasome genes among 62 T. cruzi seropositive patients from Bolivia (38 cases with CCC and 24 asymptomatic controls) to uncover associations with CCC. All subjects underwent a complete medical examination including electrocardiogram (EKG) and echocardiogram. After genotype calling and quality control filtering with exclusion of 3 cases and 3 controls, association analysis was performed across 76 directly genotyped SNPs in NLRP1, CARD, and CASP1 genes, adjusting for age, sex, and population stratification. One SNP (rs11651270; Bonferroni-corrected p = 0.036) corresponding to a missense mutation in NLPR1 was found to be significant after adjustment for multiple testing, and a suggestive association was seen in CARD11 (rs6953573; Bonferroni-corrected p = 0.060). Although limited by sample size, the study results suggest variations in the inflammasome, particularly in NLRP1 and CARD11, may be associated with CCC.

  5. Bone mineral density abnormalities in HIV infected patients and HIV ...

    African Journals Online (AJOL)

    Bone mineral density abnormalities in HIV infected patients and HIV ... Comprehensive Care Clinic (CCC) and a HIV negative control group seen at the ... Older patients had lower levels of BMD (i.e. more negative BMD. p-value = 0.032).

  6. Communication Profile of Primary School-Aged Children with Foetal Growth Restriction

    Science.gov (United States)

    Partanen, Lea Aulikki; Olsén, Päivi; Mäkikallio, Kaarin; Korkalainen, Noora; Heikkinen, Hanna; Heikkinen, Minna; Yliherva, Anneli

    2017-01-01

    Foetal growth restriction is associated with problems in neurocognitive development. In the present study, prospectively collected cohorts of foetal growth restricted (FGR) and appropriate for gestational age grown (AGA) children were examined at early school-age by using the Children's Communication Checklist-2 (CCC-2) to test the hypothesis that…

  7. 7 CFR 1425.3 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... administration. The terms defined in parts 718 of this title and parts 1421 and 1427 of this chapter shall also... approved by CCC to obtain marketing assistance loans or Loan deficiency payments. Cooperative is a business... cooperative principles. Eligible commodity is a commodity which meets the commodity's eligibility requirements...

  8. 7 CFR 1491.30 - Violations and remedies.

    Science.gov (United States)

    2010-01-01

    ..., NRCS shall collect CCC's share of the conservation easement based on the appraised fair market value of... the conservation easement. (b) In the event that the entity fails to enforce any of the terms of the conservation easement, as determined in the sole discretion of the Chief, the Chief and his or her successors...

  9. Quantitative Evaluation of Temporal Regularizers in Compressed Sensing Dynamic Contrast Enhanced MRI of the Breast

    Directory of Open Access Journals (Sweden)

    Dong Wang

    2017-01-01

    Full Text Available Purpose. Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI is used in cancer imaging to probe tumor vascular properties. Compressed sensing (CS theory makes it possible to recover MR images from randomly undersampled k-space data using nonlinear recovery schemes. The purpose of this paper is to quantitatively evaluate common temporal sparsity-promoting regularizers for CS DCE-MRI of the breast. Methods. We considered five ubiquitous temporal regularizers on 4.5x retrospectively undersampled Cartesian in vivo breast DCE-MRI data: Fourier transform (FT, Haar wavelet transform (WT, total variation (TV, second-order total generalized variation (TGVα2, and nuclear norm (NN. We measured the signal-to-error ratio (SER of the reconstructed images, the error in tumor mean, and concordance correlation coefficients (CCCs of the derived pharmacokinetic parameters Ktrans (volume transfer constant and ve (extravascular-extracellular volume fraction across a population of random sampling schemes. Results. NN produced the lowest image error (SER: 29.1, while TV/TGVα2 produced the most accurate Ktrans (CCC: 0.974/0.974 and ve (CCC: 0.916/0.917. WT produced the highest image error (SER: 21.8, while FT produced the least accurate Ktrans (CCC: 0.842 and ve (CCC: 0.799. Conclusion. TV/TGVα2 should be used as temporal constraints for CS DCE-MRI of the breast.

  10. LDV measurement, flow visualization and numerical analysis of flow distribution in a close-coupled catalytic converter

    International Nuclear Information System (INIS)

    Kim, Duk Sang; Cho, Yong Seok

    2004-01-01

    Results from an experimental study of flow distribution in a Close-coupled Catalytic Converter (CCC) are presented. The experiments were carried out with a flow measurement system specially designed for this study under steady and transient flow conditions. A pitot tube was a tool for measuring flow distribution at the exit of the first monolith. The flow distribution of the CCC was also measured by LDV system and flow visualization. Results from numerical analysis are also presented. Experimental results showed that the flow uniformity index decreases as flow Reynolds number increases. In steady flow conditions, the flow through each exhaust pipe made some flow concentrations on a specific region of the CCC inlet. The transient test results showed that the flow through each exhaust pipe in the engine firing order, interacted with each other to ensure that the flow distribution was uniform. The results of numerical analysis were qualitatively accepted with experimental results. They supported and helped explain the flow in the entry region of CCC

  11. 7 CFR 1437.303 - Aquaculture, including ornamental fish.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Aquaculture, including ornamental fish. 1437.303... ASSISTANCE PROGRAM Determining Coverage Using Value § 1437.303 Aquaculture, including ornamental fish. (a... human consumption as determined by CCC. (2) Fish raised as feed for other fish that are consumed by...

  12. Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer

    DEFF Research Database (Denmark)

    Blomberg Jensen, Martin; Andersen, Claus B.; Nielsen, John E

    2010-01-01

    The vitamin D receptor (VDR), CYP27B1 and CYP24A1 are expressed in the human kidney, but the segmental expression of the 25-hydroxylases is unknown. A comprehensive analysis of CYP2R1, CYP27A1, CYP27B1, VDR and CYP24A1 expression in normal kidney and renal clear cell cancer (CCc) would reveal...

  13. 7 CFR 1488.3 - General.

    Science.gov (United States)

    2010-01-01

    ... increase total commercial sales of agricultural commodities to the importing country. ... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS FINANCING OF SALES OF AGRICULTURAL COMMODITIES Financing of Export Sales of Agricultural Commodities From Private Stocks Under CCC Export Credit Sales Program (GSM-5...

  14. Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?

    Science.gov (United States)

    Borges, Juliana Pereira; Mendes, Fernanda de Souza Nogueira Sardinha; Lopes, Gabriella de Oliveira; Sousa, Andréa Silvestre de; Mediano, Mauro Felippe Felix; Tibiriçá, Eduardo

    2018-08-15

    Chronic Chagas cardiomyopathy (CCC) and cardiomyopathies due to other etiologies involve differences in pathophysiological pathways that are still unclear. Systemic microvascular abnormalities are associated with the pathogenesis of ischemic heart disease. However, systemic microvascular endothelial function in CCC remains to be elucidated. Thus, we compared the microvascular endothelial function of patients presenting with CCC to those with ischemic cardiomyopathy disease. Microvascular reactivity was assessed in 21 patients with cardiomyopathy secondary to Chagas disease, 21 patients with cardiomyopathy secondary to ischemic disease and 21 healthy controls. Microvascular blood flow was assessed in the skin of the forearm using laser speckle contrast imaging coupled with iontophoresis of acetylcholine (ACh). Peak increase in forearm blood flow with ACh iontophoresis in relation to baseline was greater in healthy controls than in patients with heart disease (controls: 162.7 ± 58.4% vs. ischemic heart disease: 74.1 ± 48.3% and Chagas: 85.1 ± 68.1%; p < 0.0001). Patients with Chagas and ischemic cardiomyopathy presented similar ACh-induced changes from baseline in skin blood flow (p = 0.55). Endothelial microvascular function was equally impaired among patients with CCC and ischemic cardiomyopathy. Copyright © 2018 Elsevier B.V. All rights reserved.

  15. 7 CFR 1485.13 - Application process and strategic plan.

    Science.gov (United States)

    2010-01-01

    ... requested for brand activities; (J) Percentage of CCC resources requested for brand activities that will be... affiliated organizations; (D) A description of management and administrative capability; (E) A description of... entity. (iii) Applicants seeking funds for brand promotion shall contain the information required by...

  16. Simplified calculus for the design of a cryogenic current comparator

    NARCIS (Netherlands)

    Sesé, J.; Bartolomé, M.E.; Camón, A.; Flokstra, Jakob; Rietveld, G.; Rillo, C.

    2002-01-01

    The calculation of inductances of superconducting structures like the cryogenic current comparator (CCC) is not straightforward due to image effects. We have found a "rule of thumb" that maximizes the value of an inductance inside a superconducting shield. With this rule, the design of an optimum

  17. Simplified calculus for the Design of a Cryogenic Current Comparator

    NARCIS (Netherlands)

    Sesé, J.; Bartolomé, M.E.; Camón, Agustin; Flokstra, Jakob; Rietveld, Gert; Rillo, Conrado

    2003-01-01

    The calculation of inductances of superconducting structures like the cryogenic current comparator (CCC) is not straightforward due to image effects and unknown current distributions. By treating the problem as a magnetic circuit, an approximate analytical expression for the self-inductance of the

  18. Applying Cultura in the Community College Counseling Practice

    Science.gov (United States)

    Arteaga, Blanca E.

    2015-01-01

    Latino students represent the fastest-growing population in the state of California, the United States, and the California Community College (CCC) system. Unfortunately, compared to other ethnic groups, Latino community college students continue to lag academically. Given the importance of counseling services and the scarce research related to…

  19. Computer Programs in Marine Science

    Science.gov (United States)

    1976-04-01

    Technology Room 5-207 Cambridge, HA 02139 Telephone (617) 253-5941 Currcnt Profiles from Tilt Data Language - Hardware - ,.alculate3 current profiles gene ...HORIZCNTAL FANC -E 120 FORTRAN CCC 3800 LINE FRINTER PLOTS 16 FORTRAN CDC 1800 INTERNAL GkAVITY UAVLS CISPER 186 107 FIRTRAN CDC 3800 ANNOTATED TRACK ON

  20. The CERN Control Centre is up and running!

    CERN Multimedia

    Maximilien Brice

    2006-01-01

    The CERN Control Centre (CCC) that combines all the control rooms for the accelerators, the cryogenic system and the technical infrastructure came into operation on 1st February. On 1st February, at 2.00 p.m., Patrick Villeton Pachot started the first Technical Infrastructure shift at the brand new CERN Control Centre.

  1. 7 CFR 1425.23 - Reports.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Reports. 1425.23 Section 1425.23 Agriculture... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COOPERATIVE MARKETING ASSOCIATIONS § 1425.23 Reports. (a) CMA's shall annually provide CCC a report of all commodity deliveries involved in loans and LDP's by...

  2. 76 FR 50167 - Submission for OMB Review; Comment Request

    Science.gov (United States)

    2011-08-12

    ..., electronic, mechanical, or other technological collection techniques or other forms of information technology... 9 affects the manner in which the CCC and FSA, as well as any other creditor, perfect and liquidate... Programs will complete the ``Service Agreement and Attendance Record''. The Agency will use the recording...

  3. Fundamental particles Bat 774 at CERN

    CERN Document Server

    Soppelsa, Francesco

    2016-01-01

    The book talks about the design and construction of the building 774 at CERN. The building 774 is a unique building both for its architectural value and for its location. Located in front of of the CCC (Control Center) at CERN is the main door of more than 100,000 tourists come visiting CERN each year.

  4. 7 CFR 1435.200 - Information reporting.

    Science.gov (United States)

    2010-01-01

    ..., consumption, stocks and trade of sugar in Mexico and publish the data in each edition of the World... on the production, consumption, and trade of high fructose corn syrup in Mexico and publish the data... administered under the general supervision of the Executive Vice President, CCC. [67 FR 54928, Aug. 26, 2002...

  5. 7 CFR 1427.174 - Maturity of seed cotton loans.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Maturity of seed cotton loans. 1427.174 Section 1427.174 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION... Maturity of seed cotton loans. Seed cotton loans mature on demand by CCC but no later than May 31 following...

  6. 7 CFR 1488.18 - Covenant against contingent fees.

    Science.gov (United States)

    2010-01-01

    ... 1488.18 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT... Export Credit Sales Program (GSM-5) Miscellaneous Provisions § 1488.18 Covenant against contingent fees... financing agreement. Such amounts shall, on demand, be refunded to CCC by the exporter. ...

  7. 7 CFR 1403.4 - Demand for payment of debts.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Demand for payment of debts. 1403.4 Section 1403.4 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT... Demand for payment of debts. (a) When a debt is due CCC, an initial written demand for payment of such...

  8. SHORT COMMUNICATION ISOLATION OF CHLOROPHYLL A ...

    African Journals Online (AJOL)

    a

    chromatography (CCC) technique has been applied to the separation of chlorophyll a from ... auxiliary gas flow rate, 0.06 L min-1; ion spray voltage, 3.5 kV; capillary .... This work presents a successful application of column chromatography ...

  9. Tetra-cationic imidazoliumyl-substituted phosphorus-sulfur heterocycles from a cationic organophosphorus sulfide

    Czech Academy of Sciences Publication Activity Database

    Henne, F. D.; Watt, F. A.; Schwedtmann, K.; Hennersdorf, F.; Kokoschka, Malte; Weigand, J. J.

    2016-01-01

    Roč. 52, č. 10 (2016), s. 2023-2026 ISSN 1359-7345 Institutional support: RVO:61388963 Keywords : crystal structures * density * carbene Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 6.319, year: 2016 http://pubs.rsc.org/en/content/articlepdf/2016/cc/c5cc08182c

  10. Mannose-Binding Lectin and Toll-Like Receptor Polymorphisms and Chagas Disease in Chile

    Science.gov (United States)

    Zulantay, Inés; Danquah, Ina; Hamann, Lutz; Schumann, Ralf R.; Apt, Werner; Mockenhaupt, Frank P.

    2012-01-01

    Mannose-binding lectin (MBL) and Toll-like receptor (TLR) polymorphisms may influence susceptibility and manifestation of Trypanosoma cruzi infection. In northern Chile, we examined 61 asymptomatic patients with chronic Chagas disease (CD), 64 patients with chronic Chagas cardiomyopathy (CCC), and 45 healthy individuals. Low-producer MBL2*B genotypes were more common in CD patients (48%) than healthy individuals (31%; adjusted odds ratio = 2.3, 95% confidence interval = 1.01–5.4, P = 0.047) but did not differ with manifestation. In contrast, the heterozygous Toll-like receptor 4 (TLR4)-deficiency genotype D299G/T399I occurred more frequently in asymptomatic (14.8%) than CCC patients (3.1%; P = 0.02). TLR1-I602S, TLR2-R753Q, TLR6-S249P, and MAL/TIRAP-S180L did not associate with CD or CCC. These findings support the complement system to be involved in defense against Trypanosoma cruzi infection and indicate that curbed TLR4 activation might be beneficial in preventing CCC. PMID:22302853

  11. Evaluation of the Radiography Program at Caldwell Community College and Technical Institute--Summer, 1982.

    Science.gov (United States)

    Pipes, V. David

    As part of a periodic evaluation of the occupational programs at Caldwell Community College and Technical Institute (CCC&TI), a study of the radiography program was conducted to collect information to facilitate planning, aid in program improvement, and meet accountability demands. The specific objectives of the program evaluation were to…

  12. 7 CFR 1427.1081 - General statement and administration.

    Science.gov (United States)

    2010-01-01

    ... by the Director, KCCO, or the Director's designee, the financial statement of a parent company, which includes the financial position of a wholly-owned subsidiary, may be used to meet the CCC standards for... Linters,” (2) A current financial statement on Form WA-51, “Financial Statement”, supported by such...

  13. 7 CFR 1493.130 - Recovery of losses.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Recovery of losses. 1493.130 Section 1493.130...) Operations § 1493.130 Recovery of losses. (a) Notification. Upon payment of loss to the exporter or the... by CCC's Payment Guarantee: $4,668.55 Computation of Pro Rata Sharing in Recovery of Losses In...

  14. A review of the role and remit of the committee on climate change

    International Nuclear Information System (INIS)

    McGregor, Peter G.; Kim Swales, J.; Winning, Matthew A.

    2012-01-01

    Domestic action on climate change requires a combination of solutions, in terms of institutions and policy instruments. One way of achieving government carbon policy goals may be the creation of an independent body to advise on, or set, monitor policy. This paper critically assesses the Committee on Climate Change (CCC), which was created in 2008 as an independent body to help move the UK towards a low-carbon economy. We look at the motivation for its creation. In particular we consider its ability to overcome a time-inconsistency problem by comparing it to another independent body, the Monetary Policy Committee of the Bank of England. In practice the CCC appears to be the “inverse” of the Monetary Policy Committee, in that it advises on what the policy goal should be rather than being held responsible for achieving it. The CCC incorporates both advisory and monitoring functions to inform government and achieve a credible carbon policy over a long time frame. This is a similar framework to that adopted by , but the CCC operates on a continuing basis and also incorporates a unique climate change monitoring function. - Highlights: ► Compares Committee on Climate Change with Monetary Policy Committee to solve time-inconsistency. ► No delegation of independent instrument to Committee on Climate Change. ► Committee on Climate Change best viewed as a continuous version of the Stern Report. ► Also additional monitoring function to check government progress on climate change.

  15. Analysis of femtosecond laser assisted capsulotomy cutting edges and manual capsulorhexis using environmental scanning electron microscopy.

    Science.gov (United States)

    Serrao, Sebastiano; Lombardo, Giuseppe; Desiderio, Giovanni; Buratto, Lucio; Schiano-Lomoriello, Domenico; Pileri, Marco; Lombardo, Marco

    2014-01-01

    Purpose. To investigate the structure and irregularity of the capsulotomy cutting edges created by two femtosecond (FS) laser platforms in comparison with manual continuous circular capsulorhexis (CCC) using environmental scanning electron microscopy (eSEM). Methods. Ten anterior capsulotomies were obtained using two different FS laser cataract platforms (LenSx, n = 5, and Victus, n = 5). In addition, five manual CCC (n = 5) were obtained using a rhexis forceps. The specimens were imaged by eSEM (FEI Quanta 400, OR, USA). Objective metrics, which included the arithmetic mean deviation of the surface (Sa) and the root-mean-square deviation of the surface (Sq), were used to evaluate the irregularity of both the FS laser capsulotomies and the manual CCC cutting edges. Results. Several microirregularities were shown across the FS laser capsulotomy cutting edges. The edges of manually torn capsules were shown, by comparison of Sa and Sq values, to be smoother (P < 0.05) than the FS laser capsulotomy edges. Conclusions. Work is needed to understand whether the FS laser capsulotomy edge microirregularities, not seen in manual CCC, may act as focal points for the concentration of stress that would increase the risk of capsular tear during phacoemulsification as recently reported in the literature.

  16. Analysis of Femtosecond Laser Assisted Capsulotomy Cutting Edges and Manual Capsulorhexis Using Environmental Scanning Electron Microscopy

    Directory of Open Access Journals (Sweden)

    Sebastiano Serrao

    2014-01-01

    Full Text Available Purpose. To investigate the structure and irregularity of the capsulotomy cutting edges created by two femtosecond (FS laser platforms in comparison with manual continuous circular capsulorhexis (CCC using environmental scanning electron microscopy (eSEM. Methods. Ten anterior capsulotomies were obtained using two different FS laser cataract platforms (LenSx, n=5, and Victus, n=5. In addition, five manual CCC (n=5 were obtained using a rhexis forceps. The specimens were imaged by eSEM (FEI Quanta 400, OR, USA. Objective metrics, which included the arithmetic mean deviation of the surface (Sa and the root-mean-square deviation of the surface (Sq, were used to evaluate the irregularity of both the FS laser capsulotomies and the manual CCC cutting edges. Results. Several microirregularities were shown across the FS laser capsulotomy cutting edges. The edges of manually torn capsules were shown, by comparison of Sa and Sq values, to be smoother (P<0.05 than the FS laser capsulotomy edges. Conclusions. Work is needed to understand whether the FS laser capsulotomy edge microirregularities, not seen in manual CCC, may act as focal points for the concentration of stress that would increase the risk of capsular tear during phacoemulsification as recently reported in the literature.

  17. 7 CFR 1416.201 - Definitions.

    Science.gov (United States)

    2010-01-01

    .... Goats will be further delineated by sex (bucks and does) and age (kids). Kid means a goat less than 1... geese. Poultry will be further delineated by sex, age and purpose of production, as determined by CCC... further delineated by sex (rams and ewes) and age (lambs). Swine means domesticated omnivorous pigs, hogs...

  18. Contrast-Induced Nephropathy Is Less Common in Patients with Good Coronary Collateral Circulation.

    Science.gov (United States)

    Avci, Eyup; Yildirim, Tarik; Kadi, Hasan

    2017-10-01

    Contrast-induced nephropathy (CIN) is a typically reversible type of acute renal failure that develops after exposure to contrast agents; underlying endothelial dysfunction is thought to be an important risk factor for CIN. Although the mechanism of coronary collateral circulation (CCC) is not fully understood, a pivotal role of the endothelium has been reported in many studies. The aim of this study was to investigate whether there is a relationship between CCC and CIN. Patients with at least one occluded major coronary artery and blood creatinine analyses performed before and on the second day after angiography were included in the study. CIN was defined as a 25% or greater elevation of creatinine on the second day after exposure to the contrast agent. Collateral grading was performed according to the Rentrop classification. Patients were grouped according to whether they developed CIN or not, i.e., CIN(-) and CIN(+) group. A total of 214 patients who met the inclusion criteria were included in the study. CIN was diagnosed in 43 patients (20.1%) in the study population. Good CCC was identified in 112 patients (65.5%) in the CIN(-) group, whereas it was identified in 13 patients (30.2%) in the CIN(+) group. In the CIN(-) group, good CCC was significantly more frequent ( p Good collateral circulation was associated with a lower frequency of CIN, and poor collateral circulation was an independent predictor of CIN.

  19. US Army Order of Battle 1919-1941. Volume 4. The Services: Quartermaster, Medical, Military Police, Signal Corps, Chemical Warfare, and Miscellaneous Organizations, 1919-41

    Science.gov (United States)

    2010-01-01

    Battalion from the 320th Wagon Company at Alpena , MI. E Company from the 320th Motor Repair Section at Pontiac, MI. F Company from the 310th Motorcycle...of the following counties in Michigan: Alpena , Oscoda, Alcona, Osco, and parts of Crawford and Montmorency. Discontinued 31 March 1935. 4th CCC

  20. 7 CFR 1410.22 - CRP conservation plan.

    Science.gov (United States)

    2010-01-01

    ... productive capability of the soil, improve water quality, protect wildlife or wetlands, protect a public well... plans and revisions of such plans shall be subject to the approval of CCC. (f) Mid-cover management... 7 Agriculture 10 2010-01-01 2010-01-01 false CRP conservation plan. 1410.22 Section 1410.22...

  1. 7 CFR 1486.103 - Are regional projects possible under the program?

    Science.gov (United States)

    2010-01-01

    ... consideration provided such projects target qualifying emerging markets in the specified region. CCC may consider activities which target qualified emerging markets in a specific region, but are conducted in a non-emerging market because of its importance as a central location and ease of access to that region. ...

  2. A Qualitative Metasynthesis of Consultation Process Research: What We Know and Where to Go

    Science.gov (United States)

    Newman, Daniel S.; McKenney, Elizabeth L. W.; Silva, Arlene E.; Clare, Mary; Salmon, Diane; Jackson, Safiyah

    2017-01-01

    Qualitative metasynthesis (QM) is a research methodology that permits the meaningful integration and interpretation of qualitative research. This study applies a QM approach combined with constructivist grounded theory methods, bolstered by several features of research credibility, to examine the state of consultee-centered consultation (CCC) and…

  3. 76 FR 2728 - Securities Investor Protection Corporation; Order Approving a Proposed Bylaw Change Relating to...

    Science.gov (United States)

    2011-01-14

    ... on SIPC Members January 10, 2011. On October 8, 2010, the Securities Investor Protection Corporation... pursuant to Section 3(e)(1) of the Securities Investor Protection Act of 1970 (``SIPA''), 15 U.S.C. 78ccc(e... SECURITIES AND EXCHANGE COMMISSION [Release No. SIPA-170; File No. SIPC-2010-01] Securities...

  4. Foliar application of chlorocholine chloride improves leaf mineral nutrition, antioxidant enzyme activity, and tuber yield of potato (Solanum tuberosum L.)

    DEFF Research Database (Denmark)

    Wang, Huigun; Xiao, Langtao; Tong, Jianhua

    2010-01-01

    activity. Results showed that 1.5 and 2.0 g l-1 CCC treatments significantly increased the contents of P, K, Ca, Mg, Fe, Mn, Zn and Cu in potato leaves. These treatments also increased superoxide dismutase (SOD), peroxidases (POD) and catalase (CAT) activities in the leaves. A positive linear relationship...

  5. 7 CFR 1485.15 - Activity plan.

    Science.gov (United States)

    2010-01-01

    ... any changes in strategy from the strategic plan; (iii) A budget for each proposed activity... with respect to contributions and program evaluations. A participant may undertake promotional... accountable to CCC for all such promotional activities and related expenditures. (g) Activity plan changes. (1...

  6. 7 CFR 1436.8 - Security for loan.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Security for loan. 1436.8 Section 1436.8 Agriculture... Security for loan. (a) Except as agreed to by CCC, all loans must be secured by a promissory note and... prior lien holders. (2) A loan will be considered to be adequately secured when the real estate security...

  7. Effect of growth regulators on growth, flowering and rhizome yield of ...

    African Journals Online (AJOL)

    Field experiments were conducted in 2001 and 2002, to study the effect of foliar application of growth regulators on growth; flowering and rhizome yield of ginger (Zingiber officinale Rosc.). Treatments consisted of gibberellic acid (GA3) at 0,150 and 300 ppm; ethrel at 0,100 and 200 ppm and cycocel (CCC) at 0,250 ppm ...

  8. 7 CFR 1421.6 - Beneficial interest.

    Science.gov (United States)

    2010-01-01

    ... tendered to CCC as collateral for a marketing assistance loan or of the commodity that will be used to... interest in the commodity tendered as collateral for the loan, a person must: (1) Be the producer of the... whether the commodity will be tendered as collateral for a loan, when the loan will be repaid, or if the...

  9. 7 CFR 1401.4 - Commodity certificates.

    Science.gov (United States)

    2010-01-01

    ... this section of loan collateral by a person to whom a loan secured by such collateral is made): or... loan collateral—(1) General. Except as otherwise provided in this paragraph and in paragraphs (f) and... commodities pledged as collateral for CCC loans made to such person, at any time on or before the expiration...

  10. 7 CFR 1427.175 - Liability of the producer.

    Science.gov (United States)

    2010-01-01

    ..., maintaining a loan, or settling a loan or if the producer disposes of or moves the loan collateral without the... disposition or movement of the loan collateral; (iv) Applicable interest on such amounts; and (v) Liquidated... moved, the loan collateral without prior written approval from CCC, the value of such collateral...

  11. 7 CFR 1435.102 - Eligibility requirements.

    Science.gov (United States)

    2010-01-01

    ... to be eligible to be pledged as loan collateral: (1) Refined beet sugar to be pledged as loan... yield raw cane sugar or refined beet sugar, as determined by CCC. (e) The loan collateral must be stored... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS SUGAR PROGRAM Sugar Loan Program § 1435.102...

  12. 7 CFR 1421.113 - Recourse marketing assistance loans.

    Science.gov (United States)

    2010-01-01

    ... assistance loan collateral may not be delivered or forfeited to CCC in satisfaction of the loan indebtedness... 7 Agriculture 10 2010-01-01 2010-01-01 false Recourse marketing assistance loans. 1421.113 Section... CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS GRAINS AND SIMILARLY HANDLED...

  13. 7 CFR 1435.105 - Loan settlement and foreclosure.

    Science.gov (United States)

    2010-01-01

    ... all or any part of the loan collateral by paying CCC the applicable principal and interest. (b) Forfeiture of sugar loan collateral will be accepted as payment in full of the principal and interest due...) Forfeiture of in-process sugar serving as loan collateral will be accepted as payment in full of principal...

  14. 7 CFR 1427.12 - Liens.

    Science.gov (United States)

    2010-01-01

    ... tendered as collateral for a loan, even though the liens or encumbrances are satisfied from the loan... less than $50,000. (b) CCC may elect to accept cotton as loan collateral that has warehouse receiving... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS COTTON Nonrecourse Cotton Loan and Loan Deficiency Payments...

  15. Creating and Maintaining a Wellness Environment in Child Care Centers Participating in the Child and Adult Care Food Program

    Science.gov (United States)

    Lofton, Kristi L.; Carr, Deborah H.

    2010-01-01

    Purpose/Objectives: This study identifies issues associated with creating and maintaining a wellness environment in child care centers (CCCs) participating in the Child and Adult Care Food Program (CACFP). Methods: Structured interviews and focus groups were conducted with CCC professionals and state agency personnel to develop a survey to assess…

  16. The Coast Artillery Journal. Volume 78, Number 2, March-April 1935

    Science.gov (United States)

    1935-04-01

    Craig, C.A.C., assigned to command Battery "B" Captain Oren A. Mulkey, Infantry, assigned to Headquarters Company Pacific Sec- tor; and Lieutenant Norman ...a blow to the pride of our :1ble corps of instructors. By Lieutenant Eugene C. Smallwood , C.A .C. JENROLL~vrENT for additional members in the C.c.c

  17. 7 CFR 1436.13 - Loan installments, delinquency, and acceleration of maturity date.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Loan installments, delinquency, and acceleration of... FACILITY LOAN PROGRAM REGULATIONS § 1436.13 Loan installments, delinquency, and acceleration of maturity... delinquency, CCC may permit a rescheduling of the debt or other measures consistent with the collection of...

  18. Growing Our Workforce through Business and Education

    Science.gov (United States)

    Pauley, Douglas R.; Davidchik, Daniel

    2010-01-01

    In 2004, Central Community College (CCC) established the Mechatronics Education Center (MEC), a regional center of excellence, to help the state address the shortage of skilled technicians in the area of industrial automation. The MEC addresses the needs of the current and future workforce through the implementation of its three main components:…

  19. Specific functions of the Rep and Rep' proteins of porcine circovirus during copy-release and rolling-circle DNA replication

    Science.gov (United States)

    The roles of two porcine circovirus replication initiator proteins, Rep and Rep', in generating copy-release and rolling-circle DNA replication intermediates were determined. Rep uses the supercoiled closed-circular genome (ccc) to initiate leading-strand synthesis (identical to copy-release replica...

  20. 7 CFR Exhibit C to Subpart A of... - Memorandum of Understanding Between Farmers Home Administration or its successor agency under...

    Science.gov (United States)

    2010-01-01

    ... Grain Reserve Program, a producer may request to rotate or exchange new crop grain for the original crop... is impossible for FmHA or its successor agency under Public Law 103-354 or CCC to have a first lien...

  1. Factors Affecting Student Success in Distance Learning Courses at a Local California Community College: Joint Governance Perspectives

    Science.gov (United States)

    Gonzalez, Luis A.

    2012-01-01

    The purpose of this study was to explore the perspectives of staff and faculty regarding factors affecting student success in distance learning at a California community college (CCC). Participants were members of the leadership group known as the distance learning committee. Data were collected through in-depth interviews using open-ended…

  2. Concussion Assessment in California Community College Football: Athletic Trainers' Strides toward a Safer Return to Play

    Science.gov (United States)

    Chinn, Nancy Resendes

    2010-01-01

    The purpose of this mixed method study was to compare current practices of athletic trainers in the management of concussion in football at California Community Colleges (CCC) with the concussion management guidelines set forth by the National Athletic Trainers Association (NATA). The study also set out to gain understanding of why some athletic…

  3. The three-dimensional model for helical columns on type-J synchronous counter-current chromatography.

    Science.gov (United States)

    Guan, Y H; van den Heuvel, Remco

    2011-08-05

    Unlike the existing 2-D pseudo-ring model for helical columns undergoing synchronous type-J planetary motion of counter-current chromatograph (CCC), the 3-D "helix" model developed in this work shows that there is a second normal force (i.e. the binormal force) applied virtually in the axial direction of the helical column. This force alternates in the two opposite directions and intensifies phase mixing with increasing the helix angle. On the contrary, the 2-D spiral column operated on the same CCC device lacks this third-dimensional mixing force. The (principal) normal force quantified by this "helix" model has been the same as that by the pseudo-ring model. With β>0.25, this normal centrifugal force has been one-directional and fluctuates cyclically. Different to the spiral column, this "helix" model shows that the centrifugal force (i.e. the hydrostatic force) does not contribute to stationary phase retention in the helical column. Between the popular helical columns and the emerging spiral columns for type-J synchronous CCC, this work has thus illustrated that the former is associated with better phase mixing yet poor retention for the stationary phase whereas the latter has potential for better retention for the stationary phase yet poor phase mixing. The methodology developed in this work may be regarded as a new platform for designing optimised CCC columns for analytical and engineering applications. Copyright © 2011 Elsevier B.V. All rights reserved.

  4. 7 CFR 1493.330 - Miscellaneous provisions.

    Science.gov (United States)

    2010-01-01

    ..., shall be admitted to any share or part of the facility payment guarantee or to any benefit that may... condition, as determined by the Treasurer of CCC; or (2) Is the financial institution issuing the letter of... that owns or controls the financial institution issuing the letter of credit; or (4) Is the U.S. parent...

  5. Identification of single nucleotide polymorphism of growth hormone ...

    African Journals Online (AJOL)

    Yurnalis

    TCG, TGG, CTT, GGG, CCC, and CTG to TCG, TGG, CTG, GGC, CCT. These data provide evidence that. GH gene of this breed is slightly different from other breeds. This polymorphic source can be used to refer to performance and to investigate whether these polymorphics are responsible for quantitative variation in growth ...

  6. Preliminary genetic linkage map of Indian major carp, Labeo rohita ...

    Indian Academy of Sciences (India)

    R: TGC TGC GGG TCA TTA GTA TTC ATC. F: TTCACGGACAGATTTGACCCAG. R: AGTCTTTTCAGGAGATTAGCAG. F: TGA GAT GTT CAG CAG GAG CTC. R: GAG CGT CGA GTGGCG TTT C. F: GAT CCC AGC AGA GGC TGT G. R: AGT CTG TGC TCT CTG GAG TG. F: TGCACA CCT CGA GGT TAG CAA C. R: TCA GCT ...

  7. DQA2

    Indian Academy of Sciences (India)

    mukesh

    , GGT, CCC, TCT, GGC, CAG, TAC, ACC, CAG, GAA, TTT, GAT, GGA, GAC, GAG, ATG, TTT, TAT, GTG, GAC, CTG, GGG, AAG, AAG, GAG, ACT, GTC, TGG, AGG, CTG, CCT, ATG, TTT, AGC, CAG, TTT, GCA, GGT, TTT, GAC, CCA, CAG, GCT ...

  8. DQA1

    Indian Academy of Sciences (India)

    mukesh

    2, GAC, CAC, ATT, GGC, ACC, TAT, GGC, GTA, AGC, TTC, TAC, CAC, TCT, TAT, GGT, CCC, TCT, GGC, TAC, TAT, ATC, CAT, GAA, TTT, GAT, GGA, GAT, GAA, GAG, TTT, TAT, GTG, GAC, CTG, GAG, AAG, AGG, GAG, ACT, GTC, TGG, CAT, CTG, CCT, GTG, TTT, AGT, GAA, TTT, GCA, AGT, TTT, GAC, CCT, CAG, GAT, GGG ...

  9. Electron impact excitation of helium: A ploarization correlation study of the 31P state at 40 eV incident energy

    International Nuclear Information System (INIS)

    Harris, C.L.; Dorio, L.A.; Neill, P.A.

    1996-01-01

    Recently the Convergent Close-Coupling calculations, (CCC), of Fursa and Bray have been very successful predicting the behavior of the electron impact coherence parameters (EICP) for electron impact excitation of helium. In the present experimental study the linear Stokes parameters P 1 and P 2 have been measured for He(3 1 P) excitation using the polarization correlation technique. Data will be presented for electron impact energies of 40eV and 50eV. At present no other experimental data is available at 40eV. At 50eV angular correlation data measured using the VUV 3 1 P-1 1 S photons are available only out to a maximum electron scattering angle of 85 degrees. Due to the disadvantageous differential cross section and 40:1 branching ratio in favor of the VUV decay, the uncertainties in the present data are large. However, at selected electron scattering angles they are sufficient to distinguish the lack of convergence of the CCC predictions for the 69 state calculations (CCC69) in comparison with the 75 state model (CCC75). In particular at 50 eV incident electron energy and 120 degrees scattering angle the charge cloud alignment angles predicted by the two calculations differ by 90 degrees

  10. Position statement and guidelines on support personnel in audiology. American Speech-Language Hearing Association.

    Science.gov (United States)

    1998-01-01

    This policy document of the American Speech-Language-Hearing Association (ASHA) reflects the Association's position that the Certificate of Clinical Competence-Audiology (CCC-A) is a nationally recognized quality indicator and education standard for the profession. The following statement includes the CCC-A as the appropriate credential for audiologists supervising support personnel. The consensus panel document's exclusion of the CCC-A conflicts with ASHA's policy. Member organizations that composed the consensus panel on support personnel in audiology included: Academy of Dispensing Audiologists (ADA), American Academy of Audiology (AAA), ASHA, Educational Audiology Association (EAA), Military Audiology Association (MAA), and the National Hearing Conservation Association (NHCA). Representatives to the panel included Donald Bender (AAA) and Evelyn Cherow (ASHA), co-chairs; James McDonald and Meredy Hase (ADA); Albert deChiccis and Cheryl deConde Johnson (AAA); Chris Halpin and Deborah Price (ASHA); Peggy Benson (EAA); James Jerome (MAA); and Lloyd Bowling and Richard Danielson (NHCA). ASHA's Legislative Council and Executive Board elected not to adopt the consensus panel document because it excluded the CCC-A. In all others aspects, the documents remain similar. This position statement and guidelines supersede the audiology sections of the Guidelines for the Employment and Utilization of Supportive Personnel (LC 32-80).

  11. 7 CFR 1402.2 - Sales of inventory.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Sales of inventory. 1402.2 Section 1402.2 Agriculture... AGRICULTURE GENERAL REGULATIONS AND POLICIES POLICY FOR CERTAIN COMMODITIES AVAILABLE FOR SALE § 1402.2 Sales... owned by CCC, including those commodities that are marketed through commercial, Internet-based marketing...

  12. Modeling Concordance Correlation Coefficient for Longitudinal Study Data

    Science.gov (United States)

    Ma, Yan; Tang, Wan; Yu, Qin; Tu, X. M.

    2010-01-01

    Measures of agreement are used in a wide range of behavioral, biomedical, psychosocial, and health-care related research to assess reliability of diagnostic test, psychometric properties of instrument, fidelity of psychosocial intervention, and accuracy of proxy outcome. The concordance correlation coefficient (CCC) is a popular measure of…

  13. The Chicago Landscape of Career and Technical Education. Feature on Research and Leadership. Vol. 2, No. 1

    Science.gov (United States)

    Owens, Devean R.; Welton, Anjalé D.

    2016-01-01

    In this brief, Owens and Welton provide an introductory overview of career and technical education (CTE) programs in both Chicago Public Schools (CPS) and the City Colleges of Chicago (CCC). They report that the State of Illinois, and the City of Chicago in particular, have some of the highest unemployment rates in the country for youth ages 16 to…

  14. 7 CFR 1436.1 - Applicability.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... and security interests related to this activity may be governed by State law, CCC may adapt certain procedures relating to those issues that may vary between States. [66 FR 4612, Jan. 18, 2001, as amended at...

  15. Deriving a light use efficiency estimation algorithm using in situ hyperspectral and eddy covariance measurements for a maize canopy in Northeast China.

    Science.gov (United States)

    Zhang, Feng; Zhou, Guangsheng

    2017-07-01

    We estimated the light use efficiency ( LUE ) via vegetation canopy chlorophyll content ( CCC canopy ) based on in situ measurements of spectral reflectance, biophysical characteristics, ecosystem CO 2 fluxes and micrometeorological factors over a maize canopy in Northeast China. The results showed that among the common chlorophyll-related vegetation indices (VIs), CCC canopy had the most obviously exponential relationships with the red edge position (REP) ( R 2  = .97, p  <   .001) and normalized difference vegetation index (NDVI) ( R 2  = .91, p  <   .001). In a comparison of the indicating performances of NDVI, ratio vegetation index (RVI), wide dynamic range vegetation index (WDRVI), and 2-band enhanced vegetation index (EVI2) when estimating CCC canopy using all of the possible combinations of two separate wavelengths in the range 400-1300 nm, EVI2 [1214, 1259] and EVI2 [726, 1248] were better indicators, with R 2 values of .92 and .90 ( p  <   .001). Remotely monitoring LUE through estimating CCC canopy derived from field spectrometry data provided accurate prediction of midday gross primary productivity ( GPP ) in a rainfed maize agro-ecosystem ( R 2  = .95, p  <   .001). This study provides a new paradigm for monitoring vegetation GPP based on the combination of LUE models with plant physiological properties.

  16. A new risk scoring model for prediction of poor coronary collateral circulation in acute non-ST-elevation myocardial infarction.

    Science.gov (United States)

    İleri, Mehmet; Güray, Ümit; Yetkin, Ertan; Gürsoy, Havva Tuğba; Bayır, Pınar Türker; Şahin, Deniz; Elalmış, Özgül Uçar; Büyükaşık, Yahya

    2016-01-01

    We aimed to investigate the clinical features associated with development of coronary collateral circulation (CCC) in patients with acute non-ST-elevation myocardial infarction (NSTEMI) and to develop a scoring model for predicting poor collateralization at hospital admission. The study enrolled 224 consecutive patients with NSTEMI admitted to our coronary care unit. Patients were divided into poor (grade 0 and 1) and good (grade 2 and 3) CCC groups. In logistic regression analysis, presence of diabetes mellitus, total white blood cell (WBC) and neutrophil counts and neutrophil to lymphocyte ratio (NLR) were found as independent positive predictors of poor CCC, whereas older age (≥ 70 years) emerged as a negative indicator. The final scoring model was based on 5 variables which were significant at p risk score ≤ 1, 29 had good CCC (with a 97% negative predictive value). On the other hand, 139 patients had risk score ≥ 4; out of whom, 130 (with a 93.5% positive predictive value) had poor collateralization. Sensitivity and specificity of the model in predicting poor collateralization in patients with scores ≤ 1 and ≥ 4 were 99.2% (130/131) and +76.3 (29/38), respectively. This study represents the first prediction model for degree of coronary collateralization in patients with acute NSTEMI.

  17. Lipoprotein(a as a predictor of poor collateral circulation in patients with chronic stable coronary heart disease

    Directory of Open Access Journals (Sweden)

    Y. Fan

    Full Text Available As a mechanism compensating for obstructive coronary artery disease, coronary collateral circulation (CCC has attracted cardiologists for a long time to explore its potential impact. In the present study, Chinese patients suffering from ≥95% coronary stenosis, as diagnosed by angiography, have been investigated for the correlation between CCC and lipoprotein(a [Lp(a] levels. A cohort of 654 patients was divided into four categories according to Rentrop grades 0, 1, 2, and 3. Lp(a levels were divided into model 1, discretized with critical values of 33 and 66%, and model 2, discretized with a cutoff value of 30.0 mg/dL. Furthermore, we evaluated the correlation between CCC and serum Lp(a levels. The four groups had significantly different Lp(a levels (25.80±24.72, 18.99±17.83, 15.39±15.80, and 8.40±7.75 mg/dL; P30.0 group (OR=6.77, 95%CI=4.44-10.4 was greater than that of Lp(a <30.0 mg/dL. The worst condition of CCC can be predicted independently by Lp(a levels. In addition to clinical usage, Lp(a levels can also be utilized as biological markers.

  18. 75 FR 70811 - Commodity Assessments; Loans, Purchases, and Other Operations

    Science.gov (United States)

    2010-11-19

    ... (Braille, large print, audiotape, etc.) should contact the USDA Target Center at 202-720-2600 (voice and... assessments. When authorized by State law, CCC deducts the assessment from the proceeds of a Marketing... save producers, their marketing associations, and the States about $15,000 per year. Notice and Comment...

  19. Harmonising Nursing Terminologies Using a Conceptual Framework.

    Science.gov (United States)

    Jansen, Kay; Kim, Tae Youn; Coenen, Amy; Saba, Virginia; Hardiker, Nicholas

    2016-01-01

    The International Classification for Nursing Practice (ICNP®) and the Clinical Care Classification (CCC) System are standardised nursing terminologies that identify discrete elements of nursing practice, including nursing diagnoses, interventions, and outcomes. While CCC uses a conceptual framework or model with 21 Care Components to classify these elements, ICNP, built on a formal Web Ontology Language (OWL) description logic foundation, uses a logical hierarchical framework that is useful for computing and maintenance of ICNP. Since the logical framework of ICNP may not always align with the needs of nursing practice, an informal framework may be a more useful organisational tool to represent nursing content. The purpose of this study was to classify ICNP nursing diagnoses using the 21 Care Components of the CCC as a conceptual framework to facilitate usability and inter-operability of nursing diagnoses in electronic health records. Findings resulted in all 521 ICNP diagnoses being assigned to one of the 21 CCC Care Components. Further research is needed to validate the resulting product of this study with practitioners and develop recommendations for improvement of both terminologies.

  20. Clinical role of early dynamic FDG-PET/CT for the evaluation of renal cell carcinoma.

    Science.gov (United States)

    Nakajima, Reiko; Abe, Koichiro; Kondo, Tsunenori; Tanabe, Kazunari; Sakai, Shuji

    2016-06-01

    We studied the usefulness of early dynamic (ED) and whole-body (WB) FDG-PET/CT for the evaluation of renal cell carcinoma (RCC). One hundred patients with 107 tumours underwent kidney ED and WB FDG-PET/CT. We visually and semiquantitatively evaluated the FDG accumulation in RCCs in the ED and WB phases, and compared the accumulation values with regard to histological type (clear cell carcinoma [CCC] vs. non-clear cell carcinoma [N-CCC]), the TNM stage (high stage [3-4] vs. low stage [1-2]), the Fuhrman grade (high grade [3-4] vs. low grade [1-2]) and presence versus absence of venous (V) and lymphatic (Ly) invasion. In the ED phase, visual evaluation revealed no significant differences in FDG accumulation in terms of each item. However, the maximum standardized uptake value and tumour-to-normal tissue ratios were significantly higher in the CCCs compared to the N-CCCs (p PET/CT is a useful tool for the evaluation of RCCs. • ED and WB FDG-PET/ CT helps to assess patients with RCC • ED FDG-PET/CT enabled differentiation between CCC and N-CCC • FDG accumulation in the WB phase reflects tumour aggressiveness • Management of RCC is improved by ED and WB FDG-PET/CT.

  1. Method to generate the first design of the reload pattern to be used with the Presto-B code in the simulation of the CNLV U-1 reactor; Metodo para generar el primer diseno del patron de recarga a ser utilizado con el codigo Presto-B, en la simulacion del reactor de la CNLV U-1

    Energy Technology Data Exchange (ETDEWEB)

    Montes T, J.L.; Cortes C, C.C. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    1992-08-15

    This guide is applied for the reload pattern's formation for mirror symmetry of a core room and in accordance with the Control Cell core technique (of the english Control Cell Core - CCC) for the PRESTO-B code. (Author)

  2. Dicty_cDB: VHH513 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available KIKKK--- ---HFHTLKTLNKYIIYNDLASIRR*qltwcwfriscsfrcc*r*clgtlswiqcr*r*g nnrtfskgwscirnwhprcw*eiyghqk*hqiclr*ir...lltvn*vlvvlfalkp*lvssllsmmtn ynqvllltllkn*pii*ltttvklvffskinnvk*y Frame C: hfhtlktlnkyiiyndlasirr*qltwcwfrisc...**qittr ccc*hc*kisrlfn*qqlln*ysfqk*it*nni*nkkk--- ---HFHTLKTLNKYIIYNDLASIRR*qltwcwfriscsfrcc*r*clgtlswiqcr*r

  3. 7 CFR 1427.7 - Maturity of loans.

    Science.gov (United States)

    2010-01-01

    ... than the last day of the 9th calendar month following the month in which the note and security agreement is filed under § 1427.5(a). (2) CCC may at any time accelerate the loan maturity date by providing... cotton may have in excess of the amount of the loan, plus interest and charges. (c) Following written...

  4. Serving Canada's exporters and their customers abroad since 1946

    International Nuclear Information System (INIS)

    Benson, T.

    2000-01-01

    The Canadian Commercial Corporation (CCC) is a federal Crown corporation whose mandate is to facilitate trade between Canada and other nations, principally by partnering with Canadian suppliers in the sale of goods and services, and serving as a prime contractor and guarantor for sales by Canadian exporters to foreign buyers. CCC also acts as the purchasing agent contractor and manager for the U.S. Department of Defence of Canadian suppliers under a bilateral treaty. In essence, CCC participation constitutes a guarantee by the Canadian government that the Canadian supplier is capable, qualified, and that the contract terms will be met. The paper discusses the potential benefits of CCC participation in transactions for buyers, and for exporters, the intricacies of the progress payment program designed to provide working capital over and above normal cash flow, to share the risks amongst the parties to obtain pre-shipment financing for export sales, and to free up credit facilities. Eligibility criteria for the progress payment program, the process involved in becoming a participant, and associated costs to participants are also explained

  5. 7 CFR 1488.9 - Evidence of export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Evidence of export. 1488.9 Section 1488.9 Agriculture... Export Sales of Agricultural Commodities From Private Stocks Under CCC Export Credit Sales Program (GSM-5) Documents Required for Financing § 1488.9 Evidence of export. (a) If the commodity is exported by rail or...

  6. 7 CFR 1493.120 - Payment for loss.

    Science.gov (United States)

    2010-01-01

    ... Credit Guarantee Program (GSM-102) and CCC Intermediate Export Credit Guarantee Program (GSM-103... credit, or any obligation owed by the foreign bank to the assignee U.S. financial institution which is... with the reporting requirements under § 1493.80 and § 1493.90, excluding post-export adjustments (i.e...

  7. Enantioselective hydrogenation of cyclic imines catalysed by Noyori-Ikariya half-sandwich complexes and their analogues

    Czech Academy of Sciences Publication Activity Database

    Vilhanová, B.; Václavík, Jiří; Šot, P.; Pecháček, J.; Zápal, J.; Pažout, R.; Maixner, J.; Kuzma, M.; Kačer, P.

    2016-01-01

    Roč. 52, č. 2 (2016), s. 362-365 ISSN 1359-7345 Institutional support: RVO:61388963 Keywords : asymmetric transfer hydrogenation * ruthenium catalysts * aromatic ketones Subject RIV: CC - Organic Chemistry Impact factor: 6.319, year: 2016 http://pubs.rsc.org/en/content/articlepdf/2016/cc/c5cc06712j

  8. On Thursday 28 February, a ceremony was held to lay the foundation stone of Building 774

    CERN Multimedia

    2013-01-01

    in attendance were Stéphane Donnot, Sub-Prefect of the Ain, Octavio Mestre and Francesco Soppelsa, the building's architects, and Sigurd Lettow, Director of Administration and Infrastructure. The building will be located just opposite the CERN Control Centre (CCC); its construction is to be completed by early 2014.

  9. Evidence of impact of aviation on cirrus cloud formation

    Directory of Open Access Journals (Sweden)

    C. S. Zerefos

    2003-01-01

    Full Text Available This work examines changes in cirrus cloud cover (CCC in possible association with aviation activities at congested air corridors. The analysis is based on the latest version of the International Satellite Cloud Climatology Project D2 data set and covers the period 1984-1998. Over the studied areas, the effect of large-scale modes of natural climate variability such as ENSO, QBO and NAO as well as the possible influence of the tropopause variability, were first removed from the cloud data set in order to calculate long-term changes of observed cirrus cloudiness. The results show increasing trends in (CCC between 1984 and 1998 over the high air traffic corridors of North America, North Atlantic and Europe. Of these upward trends, only in the summertime over the North Atlantic and only in the wintertime over North America are statistically significant (exceeding +2.0% per decade. Over adjacent locations with low air traffic, the calculated trends are statistically insignificant and in most cases negative both during winter and summer in the regions studied. These negative trends, over low air traffic regions, are consistent with the observed large scale negative trends seen in (CCC over most of the northern middle latitudes and over the tropics. Moreover, further investigation of vertical velocities over high and low air traffic regions provide evidence that the trends of opposite signs in (CCC over these regions, do not seem to be caused by different trends in dynamics. It is also shown that the longitudinal distribution of decadal changes in (CCC along the latitude belt centered at the North Atlantic air corridor, parallels the spatial distribution of fuel consumption from highflying air traffic, providing an independent test of possible impact of aviation on contrail cirrus formation. The correlation between the fuel consumption and the longitudinal variability of (CCC is significant (+0.7 over the middle latitudes but not over the tropics

  10. A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation

    International Nuclear Information System (INIS)

    Wiegand, Kimberly C; Lu, Yiling; Zhang, Fan; Anglesio, Michael S; Gilks, Blake; Mills, Gordon B; Huntsman, David G; Carey, Mark S; Hennessy, Bryan T; Leung, Samuel; Wang, Yemin; Ju, Zhenlin; McGahren, Mollianne; Kalloger, Steve E; Finlayson, Sarah; Stemke-Hale, Katherine

    2014-01-01

    Ovarian cancer is now recognized as a number of distinct diseases primarily defined by histological subtype. Both clear cell ovarian carcinomas (CCC) and ovarian endometrioid carcinomas (EC) may arise from endometriosis and frequently harbor mutations in the ARID1A tumor suppressor gene. We studied the influence of histological subtype on protein expression with reverse phase protein array (RPPA) and assessed proteomic changes associated with ARID1A mutation/BAF250a expression in EC and CCC. Immunohistochemistry (IHC) for BAF250a expression was performed on 127 chemotherapy-naive ovarian carcinomas (33 CCC, 29 EC, and 65 high-grade serous ovarian carcinomas (HGSC)). Whole tumor lysates were prepared from frozen banked tumor samples and profiled by RPPA using 116 antibodies. ARID1A mutations were identified by exome sequencing, and PIK3CA mutations were characterized by MALDI-TOF mass spectrometry. SAM (Significance Analysis of Microarrays) was performed to determine differential protein expression by histological subtype and ARID1A mutation status. Multivariate logistic regression was used to assess the impact of ARID1A mutation status/BAF250a expression on AKT phosphorylation (pAKT). PIK3CA mutation type and PTEN expression were included in the model. BAF250a knockdown was performed in 3 clear cell lines using siRNA to ARID1A. Marked differences in protein expression were observed that are driven by histotype. Compared to HGSC, SAM identified over 50 proteins that are differentially expressed in CCC and EC. These included PI3K/AKT pathway proteins, those regulating the cell cycle, apoptosis, transcription, and other signaling pathways including steroid hormone signaling. Multivariate models showed that tumors with loss of BAF250a expression showed significantly higher levels of AKT-Thr 308 and AKT-Ser 473 phosphorylation (p < 0.05). In 31 CCC cases, pAKT was similarly significantly increased in tumors with BAF250a loss on IHC. Knockdown of BAF250a by siRNA in

  11. Study of 201 Non-Small Cell Lung Cancer Patients Given Stereotactic Ablative Radiation Therapy Shows Local Control Dependence on Dose Calculation Algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Latifi, Kujtim, E-mail: Kujtim.Latifi@Moffitt.org [Department of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida (United States); Oliver, Jasmine [Department of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida (United States); Department of Physics, University of South Florida, Tampa, Florida (United States); Baker, Ryan [University of South Florida School of Medicine, Tampa, Florida (United States); Dilling, Thomas J.; Stevens, Craig W. [Department of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida (United States); Kim, Jongphil; Yue, Binglin [Department of Biostatics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida (United States); DeMarco, MaryLou; Zhang, Geoffrey G.; Moros, Eduardo G.; Feygelman, Vladimir [Department of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida (United States)

    2014-04-01

    Purpose: Pencil beam (PB) and collapsed cone convolution (CCC) dose calculation algorithms differ significantly when used in the thorax. However, such differences have seldom been previously directly correlated with outcomes of lung stereotactic ablative body radiation (SABR). Methods and Materials: Data for 201 non-small cell lung cancer patients treated with SABR were analyzed retrospectively. All patients were treated with 50 Gy in 5 fractions of 10 Gy each. The radiation prescription mandated that 95% of the planning target volume (PTV) receive the prescribed dose. One hundred sixteen patients were planned with BrainLab treatment planning software (TPS) with the PB algorithm and treated on a Novalis unit. The other 85 were planned on the Pinnacle TPS with the CCC algorithm and treated on a Varian linac. Treatment planning objectives were numerically identical for both groups. The median follow-up times were 24 and 17 months for the PB and CCC groups, respectively. The primary endpoint was local/marginal control of the irradiated lesion. Gray's competing risk method was used to determine the statistical differences in local/marginal control rates between the PB and CCC groups. Results: Twenty-five patients planned with PB and 4 patients planned with the CCC algorithms to the same nominal doses experienced local recurrence. There was a statistically significant difference in recurrence rates between the PB and CCC groups (hazard ratio 3.4 [95% confidence interval: 1.18-9.83], Gray's test P=.019). The differences (Δ) between the 2 algorithms for target coverage were as follows: ΔD99{sub GITV} = 7.4 Gy, ΔD99{sub PTV} = 10.4 Gy, ΔV90{sub GITV} = 13.7%, ΔV90{sub PTV} = 37.6%, ΔD95{sub PTV} = 9.8 Gy, and ΔD{sub ISO} = 3.4 Gy. GITV = gross internal tumor volume. Conclusions: Local control in patients receiving who were planned to the same nominal dose with PB and CCC algorithms were statistically significantly different. Possible

  12. Cryogenic current comparators for precise ion beam current measurements

    International Nuclear Information System (INIS)

    Kurian, Febin

    2015-01-01

    The planned Facility for Antiproton and Ion Research (FAIR) at GSI has to cope with a wide range of beam intensities in its high-energy beam transport systems and in the storage rings. To meet the requirements of a non-intercepting intensity measurement down to nA range, it is planned to install a number of Cryogenic Current Comparator (CCC) units at different locations in the FAIR beamlines. In this work, the first CCC system for intensity measurement of heavy ion beams, which was developed at GSI, was re-commissioned and upgraded to be used as a 'GSI - CCC prototype' for extensive optimization and development of an improved CCC for FAIR. After installation of a new SQUID sensor and related electronics, as well as implementation of improved data acquisition components, successful beam current measurements were performed at a SIS18 extraction line. The measured intensity values were compared with those of a Secondary Electron Monitor (SEM). Furthermore, the spill-structure of a slowly extracted beam was measured and analyzed, investigating its improvement due to bunching during the slow-extraction process. Due to the extreme sensitivity of the superconducting sensor, the determined intensity values as well as the adjustment of the system for optimal performance are strongly influenced by the numerous noise sources of the accelerators environment. For this reason, detailed studies of different effects caused by noise have been carried out, which are presented together with proposals to reduce them. Similarly, studies were performed to increase the dynamic range and overcome slew rate limitations, the results of which are illustrated and discussed as well. By combining the various optimizations and characterizations of the GSI CCC prototype with the experiences made during beam operation, criteria for a more efficient CCC System could be worked out, which are presented in this work. The details of this new design are worked out with respect to the

  13. Does flat epithelial atypia have rounder nuclei than columnar cell change/hyperplasia? A morphometric approach to columnar cell lesions of the breast.

    Science.gov (United States)

    Yamashita, Yoshiko; Ichihara, Shu; Moritani, Suzuko; Yoon, Han-Seung; Yamaguchi, Masahiro

    2016-06-01

    Columnar cell lesions of the breast encompass columnar cell change/hyperplasia (CCC/CCH) and flat epithelial atypia (FEA). These have attracted researchers because emerging data suggest that FEA may represent the earliest histologically detectable non-obligate precursor of breast cancer. However, it is occasionally difficult to distinguish FEA from CCC/CCH because of similar histology. Although the nuclei of FEA are frequently described as relatively round compared with those of CCC/CCH, there are few morphometric studies to support this statement. The aim of this study was to provide objective data as to the nuclear shape in columnar cell lesions. As a shape descriptor, we adopted ellipticity that is defined by the formula 2b/2a, where a is the length of the long axis of the ellipse and b is the length of the short axis. Contrary to circularity, ellipticity reflects the overall configuration of an ellipse irrespective of surface irregularity. Our image analysis included generating whole slide images, extracting glandular cell nuclei, measuring nuclear ellipticity, and superimposing graded colors based on execution of results on the captured images. A total of 7917 nuclei extracted from 22 FEA images and 5010 nuclei extracted from 13 CCC/CCH images were analyzed. There was a significant difference in nuclear roundness between FEA and CCC/CCH with mean ellipticity values of 0.723 and 0.679, respectively (p < 0.001, Welch's t test). Furthermore, FEA with malignancy had significantly rounder nuclei than FEA without malignancy (p < 0.001). Our preliminary results suggest that nuclear ellipticity is a key parameter in reproducibly classifying columnar cell lesions of the breast.

  14. MicroRNA-939 governs vascular integrity and angiogenesis through targeting γ-catenin in endothelial cells

    International Nuclear Information System (INIS)

    Hou, Shiqiang; Fang, Ming; Zhu, Qian; Liu, Ying; Liu, Liang; Li, Xinming

    2017-01-01

    Coronary collateral circulation (CCC) functions as a natural bypass in the event of coronary obstruction, which markedly improves prognosis in patients with coronary artery disease (CAD). MicroRNAs (miRNAs) have been implicated in multiple physiological and pathological processes, including angiogenesis involved in CCC growth. The roles that miRNA-939 (miR-939) plays in angiogenesis remain largely unknown. We conducted this study to explore the expression of miR-939 in CAD patients and its role in angiogenesis. For the first time, our results indicated that the expression of circulating miR-939 was down-regulated in patients with sufficient CCC compared with patients with poor CCC. Overexpression of miR-939 in primary human umbilical vein endothelial cells (HUVECs) significantly inhibited the proliferation, adhesion and tube formation, but promoted the migration of cells. In contrast, miR-939 knockdown exerted reverse effects. We further identified that γ-catenin was a novel target of miR-939 by translational repression, which could rescue the effects of miR-939 in HUVECs. In summary, this study revealed that the expression of circulating miR-939 was down-regulated in CAD patients with sufficient CCC. MiR-939 abolished vascular integrity and repressed angiogenesis through directly targeting γ-catenin. It provided a potential biomarker and a therapeutic target for CAD. - Highlights: • Circulating miR-939 is decreased in sufficient coronary collateral circulation. • MiR-939 abolishes vascular integrity in endothelial cells. • MiR-939 represses angiogenesis. • γ-catenin is a novel target of miR-939.

  15. Bystander fatigue and CPR quality by older bystanders: a randomized crossover trial comparing continuous chest compressions and 30:2 compressions to ventilations.

    Science.gov (United States)

    Liu, Shawn; Vaillancourt, Christian; Kasaboski, Ann; Taljaard, Monica

    2016-11-01

    This study sought to measure bystander fatigue and cardiopulmonary resuscitation (CPR) quality after five minutes of CPR using the continuous chest compression (CCC) versus the 30:2 chest compression to ventilation method in older lay persons, a population most likely to perform CPR on cardiac arrest victims. This randomized crossover trial took place at three tertiary care hospitals and a seniors' center. Participants were aged ≥55 years without significant physical limitations (frailty score ≤3/7). They completed two 5-minute CPR sessions (using 30:2 and CCC) on manikins; sessions were separated by a rest period. We used concealed block randomization to determine CPR method order. Metronome feedback maintained a compression rate of 100/minute. We measured heart rate (HR), mean arterial pressure (MAP), and Borg Exertion Scale. CPR quality measures included total number of compressions and number of adequate compressions (depth ≥5 cm). Sixty-three participants were enrolled: mean age 70.8 years, female 66.7%, past CPR training 60.3%. Bystander fatigue was similar between CPR methods: mean difference in HR -0.59 (95% CI -3.51-2.33), MAP 1.64 (95% CI -0.23-3.50), and Borg 0.46 (95% CI 0.07-0.84). Compared to 30:2, participants using CCC performed more chest compressions (480.0 v. 376.3, mean difference 107.7; pCPR quality decreased significantly faster when performing CCC compared to 30:2. However, performing CCC produced more adequate compressions overall with a similar level of fatigue compared to the 30:2 method.

  16. High-stability cryogenic scanning tunneling microscope based on a closed-cycle cryostat.

    Science.gov (United States)

    Hackley, Jason D; Kislitsyn, Dmitry A; Beaman, Daniel K; Ulrich, Stefan; Nazin, George V

    2014-10-01

    We report on the design and operation of a cryogenic ultra-high vacuum (UHV) scanning tunneling microscope (STM) coupled to a closed-cycle cryostat (CCC). The STM is thermally linked to the CCC through helium exchange gas confined inside a volume enclosed by highly flexible rubber bellows. The STM is thus mechanically decoupled from the CCC, which results in a significant reduction of the mechanical noise transferred from the CCC to the STM. Noise analysis of the tunneling current shows current fluctuations up to 4% of the total current, which translates into tip-sample distance variations of up to 1.5 picometers. This noise level is sufficiently low for atomic-resolution imaging of a wide variety of surfaces. To demonstrate this, atomic-resolution images of Au(111) and NaCl(100)/Au(111) surfaces, as well as of carbon nanotubes deposited on Au(111), were obtained. Thermal drift analysis showed that under optimized conditions, the lateral stability of the STM scanner can be as low as 0.18 Å/h. Scanning Tunneling Spectroscopy measurements based on the lock-in technique were also carried out, and showed no detectable presence of noise from the closed-cycle cryostat. Using this cooling approach, temperatures as low as 16 K at the STM scanner have been achieved, with the complete cool-down of the system typically taking up to 12 h. These results demonstrate that the constructed CCC-coupled STM is a highly stable instrument capable of highly detailed spectroscopic investigations of materials and surfaces at the atomic scale.

  17. Electron-impact-excitation cross sections of hydrogenlike ions

    International Nuclear Information System (INIS)

    Fisher, V.I.; Ralchenko, Y.V.; Bernshtam, V.A.; Goldgirsh, A.; Maron, Y.; Vainshtein, L.A.; Bray, I.; Golten, H.

    1997-01-01

    Convergent close-coupling (CCC) and Coulomb-Born with exchange and normalization (CBE) methods are used to study electron-impact excitation of hydrogenlike ions. The nl→n ' l ' cross sections demonstrate (i) good agreement between the CCC and CBE results, (ii) a scaling over ion nuclear charge z, (iii) a domination of the dipole (l ' =l±1) contributions in total n→n ' cross sections, and (iv) significant effect of electron exchange in the energy range x n,n ' ). For ions with z>5 the n→n ' cross sections obtained in the CCC and CBE approximations agree with each other to better than 10% for any x. An accuracy of the cross sections scaling over z 4 depends on z: for z=6 endash 18 the scaling is accurate to better than 10% (quantitative analysis is done for n ' 4 scaling more significantly (at x about unity). The n→n ' cross sections are presented by a formula which fits our CCC and CBE results with an accuracy to better than 10% (for transitions with n ' 5). The new Gaunt factor G(x) suggested for the widely used Van Regemorter formula [Astrophys. J. 136, 906 (1962)] makes this formula accurate to better than 50% in the x>3 range and to better than 20% in the x>100 range. It is shown that the semiempirical formula by Vainshtein, Sobelman, and Yukov provides an accuracy to better than 50% for any incident electron energy. For x<2 this formula is accurate to better than 30%. These accuracy assessments are based on a comparison with our CCC and CBE results. copyright 1997 The American Physical Society

  18. FInal Report: Site Investigation Results, 2009-2011, at Inman, Kansas

    Energy Technology Data Exchange (ETDEWEB)

    LaFreniere, Lorraine M. [Argonne National Lab. (ANL), Argonne, IL (United States). Environmental Sciences Div.

    2015-05-01

    The Commodity Credit Corporation of the U.S. Department of Agriculture (CCC/USDA) operated a grain storage facility at the southern edge of the city of Inman, Kansas, from 1954 to 1965. During this time, commercial grain fumigants containing carbon tetrachloride were in common use by the grain storage industry to preserve grain in their facilities. In 1997, trace to low levels of carbon tetrachloride (below the maximum contamination level [MCL] of 5.0 μg/L) were detected in three private wells near the former grain storage facility at Inman, as part of a statewide USDA private well sampling program that was implemented by the Kansas Department of Health and Environment (KDHE) near former CCC/USDA facilities. No public water supply wells were identified in 1998 by the KDHE within 1 mi of the town. Carbon tetrachloride is the contaminant of primary concern at sites associated with grain storage operations. To determine whether the former CCC/USDA facility at Inman is a potential contaminant source and its possible relationship to the contamination in groundwater, the CCC/USDA agreed to conduct investigations at Inman. The investigations were performed by the Environmental Science Division of Argonne National Laboratory in accordance with the Intergovernmental Agreement between the KDHE and the Farm Service Agency of the USDA. Argonne, on behalf of the CCC/USDA, developed a Work Plan (Argonne 2007) and subsequently a Summary of Investigation Results and Proposed Work Plan (Appendix A) for a phased site investigation. The proposed work was approved by the KDHE (2007, 2011). The investigations were conducted from November 2009 to September 2011, as proposed in the two work plans. This report presents the findings of the 2009-2011 investigations at Inman.

  19. A Comparative Study of the Retentive Strengths of Commercial and Indigenously Developed Luting Cements using Both Lathe-cut and Clinically Simulated Specimens.

    Science.gov (United States)

    Mathew, Joe; Kurian, Byju P; Philip, Biju; Mohammed, Sunil; Menon, Preetha; Raj, Rajan S

    2016-08-01

    Superior adhesive strength in luting agents is of paramount significance in fixed partial denture success. In this in vitro study five cements were tested for retentive qualities, using both lathe-cut and hand-prepared specimens. A total of 104 freshly extracted tooth specimens were prepared. Seventy of them were lathe-cut and 30 specimens were hand-prepared to simulate clinical conditions. Five different cements were tested, which included a compomer, a composite, a zinc phosphate, and 2 glass-ionomer luting cements. Of the 5, 2 trial cements were indigenously developed by Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Trivandrum, India - a glass-ionomer cement (Chitra GIC) and a chemical-cure composite (Chitra CCC). All cements were compared within each group and between groups (lathe-prepared and hand-prepared). GC Fuji 1 (GC America) exhibited superior retentive strengths in both lathe-cut and hand-prepared specimens, whereas the compomer cement displayed the lowest values when tested. In lathe-cut specimens, statistical analysis showed no significant difference between GC Fuji 1 and indigenously developed Chitra CCC. Both Chitra CCC and GC Fuji 1 have comparable strengths in lathe-cut samples, making Chitra CCC a potential luting agent. Statistical analysis reveals that all cements, except GC Fuji 1, exhibited a significant decrease in strength due to the change in design uniformity. The chemical bonding of GC Fuji 1 proves to be quite strong irrespective of shape and precision of the tooth crown. The indigenously developed Chitra GIC and Chitra CCC showed promising results to be used as a potential luting agent.

  20. A simple method of measuring tibial tubercle to trochlear groove distance on MRI: description of a novel and reliable technique.

    Science.gov (United States)

    Camp, Christopher L; Heidenreich, Mark J; Dahm, Diane L; Bond, Jeffrey R; Collins, Mark S; Krych, Aaron J

    2016-03-01

    Tibial tubercle-trochlear groove (TT-TG) distance is a variable that helps guide surgical decision-making in patients with patellar instability. The purpose of this study was to compare the accuracy and reliability of an MRI TT-TG measuring technique using a simple external alignment method to a previously validated gold standard technique that requires advanced software read by radiologists. TT-TG was calculated by MRI on 59 knees with a clinical diagnosis of patellar instability in a blinded and randomized fashion by two musculoskeletal radiologists using advanced software and by two orthopaedists using the study technique which utilizes measurements taken on a simple electronic imaging platform. Interrater reliability between the two radiologists and the two orthopaedists and intermethods reliability between the two techniques were calculated using interclass correlation coefficients (ICC) and concordance correlation coefficients (CCC). ICC and CCC values greater than 0.75 were considered to represent excellent agreement. The mean TT-TG distance was 14.7 mm (Standard Deviation (SD) 4.87 mm) and 15.4 mm (SD 5.41) as measured by the radiologists and orthopaedists, respectively. Excellent interobserver agreement was noted between the radiologists (ICC 0.941; CCC 0.941), the orthopaedists (ICC 0.978; CCC 0.976), and the two techniques (ICC 0.941; CCC 0.933). The simple TT-TG distance measurement technique analysed in this study resulted in excellent agreement and reliability as compared to the gold standard technique. This method can predictably be performed by orthopaedic surgeons without advanced radiologic software. II.