34 CFR 685.100 - The William D. Ford Federal Direct Loan Program.

Science.gov (United States)

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false The William D. Ford Federal Direct Loan Program. 685...) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION WILLIAM D. FORD FEDERAL DIRECT LOAN PROGRAM Purpose and Scope § 685.100 The William D. Ford Federal Direct Loan Program. (a) Under the William D. Ford...

Test at Ford

NARCIS (Netherlands)

Davidsson, A.; Rhijn, G. van

2002-01-01

This report describes the test of the Ergotool module of the E/S tool and the participative procedure performed at the Final Assembly shop of the Wayne plant at Ford Motor Company, Michigan, USA. Three stations were selected. videotaped, measured, and evaluated according to the Ergotool and

Startup on Third Phase of Ford-China R&D Fund

Institute of Scientific and Technical Information of China (English)

2002-01-01

<正> According to Ford Auto (China) Co., Ltd., the third phase project of Ford-China Research and Development Fund, jointly established by China National Natural Science Foundation of China and American Ford Motor Co. was initiated on Jan.21 2002 in Sino-Germany Center in Beijing. The name list of the financed projects was published at the same time (See the table).

75 FR 31839 - Ford Motor Company, Receipt of Petition for Decision of Inconsequential Noncompliance

Science.gov (United States)

2010-06-04

...-0060; Notice 1] Ford Motor Company, Receipt of Petition for Decision of Inconsequential Noncompliance The Ford Motor Company (Ford) \\1\\ has determined that certain model year 2010 Ford Taurus passenger... Materials. On November 12, 2009, Ford filed an appropriate report pursuant to 49 CFR part 573, Defect and...

Ford Mustang review

DEFF Research Database (Denmark)

Herriott, Richard

2017-01-01

A review of the re-designed Ford Mustang, comparing it to the previous model. As well as making the car more refined and fluid in its appearance, the vehicle has lost some of its visual robustness. Redesigning iconic cars requires a tradeoff between visible changes from model to model but also...

76 FR 65507 - Notice of Petition for Rate Approval; Eagle Ford Midstream, LP

Science.gov (United States)

2011-10-21

... Petition for Rate Approval; Eagle Ford Midstream, LP Take notice that on October 11, 2011, (Eagle Ford..., and its initial baseline Statement of Operating Conditions. Eagle Ford states that it is an existing..., currently providing intrastate services to its customers. Eagle Ford proposed rates for Section 311...

Henry Ford Health Systems

Science.gov (United States)

Henry Ford Health Systems evolved from a hospital into a system delivering care to 2.5 million patients and includes the Cancer Epidemiology, Prevention and Control Program, which focuses on epidemiologic and public health aspects of cancer.

INOVATION AND ANTREPRENEURIAL CREATIVITY BUSINESS DURING HENRY FORD

Directory of Open Access Journals (Sweden)

GHICAJANU MIHAELA

2015-03-01

Full Text Available In this paper I presented the innovation and entrepeneurial creativity as a basis in the process of business redesign. I chose as a case study the the Ford brand products, because it is considered that Henry Ford is one of the greatest innovators and entrepreneurs of all time and I decided to present and to analyze these things. The first part of the paper will include theoretical approaches on the innovation and creativity business concepts and premises, and then I showed the ways in which four types of economic innovation under the leadership of Henry Ford (innovation in product, in process, market and organizational were achieved, with the purpose to recognize them in other companies, nowadays .

78 FR 71030 - Ford Motor Company, Denial of Petition for Decision of Inconsequential Noncompliance

Science.gov (United States)

2013-11-27

...-0005; Notice 2] Ford Motor Company, Denial of Petition for Decision of Inconsequential Noncompliance...). ACTION: Denial of Petition. SUMMARY: Ford Motor Company (Ford) has determined that certain model year 2011 Ford E-150, E-250, E-350 and E-450 motor vehicles manufactured [[Page 71031

78 FR 32531 - Ford Motor Company, Grant of Petition for Decision of Inconsequential Noncompliance

Science.gov (United States)

2013-05-30

...-0060; Notice 2] Ford Motor Company, Grant of Petition for Decision of Inconsequential Noncompliance AGENCY: National Highway Traffic Safety Administration, DOT. ACTION: Grant of Petition. SUMMARY: The Ford Motor Company (Ford), has determined that certain model year 2010 Ford Taurus passenger cars and certain...

77 FR 5301 - Ford Motor Company, Receipt of Petition for Decision of Inconsequential Noncompliance

Science.gov (United States)

2012-02-02

...-0005; Notice 1] Ford Motor Company, Receipt of Petition for Decision of Inconsequential Noncompliance AGENCY: National Highway Traffic Safety Administration, DOT. ACTION: Receipt of petition. SUMMARY: Ford Motor Company \\1\\ (Ford) has determined that certain model year 2011 Ford E-150, E-250, E-350 and E-450...

78 FR 52169 - Agency Information Collection Activities; Comment Request; Federal Direct Stafford/Ford Loan and...

Science.gov (United States)

2013-08-22

...; Comment Request; Federal Direct Stafford/Ford Loan and Federal Direct Subsidized/ Unsubsidized Stafford/Ford Loan Master Promissory Note AGENCY: Department of Education (ED), Federal Student Aid (FSA... Stafford/Ford Loan and Federal Direct Subsidized/Unsubsidized Stafford/Ford Loan Master Promissory Note...

Selection bias and the Rubin-Ford effect

International Nuclear Information System (INIS)

James, P.A.; Joseph, R.D.; Collins, C.A.

1991-01-01

We have re-examined the 'Rubin-Ford effect', and more recent claims of galaxy streaming from the same galaxy sample, to investigate the impact of selection effects on these results. A 'Monte Carlo'-type analysis was applied to simulate the selection procedure used to obtain this sample, and a strong bias was identified, resulting in apparent velocity flows at 600-800 km s -1 . Thus the 'Rubin-Ford effect' and the associated galaxy streaming are spurious effects resulting from the method of sample selection. (author)

Edificio Ford

Directory of Open Access Journals (Sweden)

Skidmore, Owings y Merrill, Arquitectos Ingenieros

1962-07-01

Full Text Available El nuevo y moderno Centro Administrativo de la Ford ocupa una de las dos torres prismáticas de la Ciudad del Automóvil, entre las cuales, un edificio bajo y espacioso que se destina a garaje, cumple el papel de plaza y jardín. Los tres bloques fundamentales están servidos por una compleja y perfecta red de tráfico rodado de acceso a los diversos servicios a distintos niveles, resuelta con maestría encomiable y funcionalismo excepcional.

Arbitraging a Discriminatory Labor Market: Black Workers at the Ford Motor Company, 19181947

OpenAIRE

Christopher L. Foote; Warren C. Whatley; Gavin Wright

2003-01-01

The 191847 employee records of the Ford Motor Company provide a rare opportunity to study a firm willing to hire black workers when similar firms would not. The evidence suggests that Ford did profit from discrimination elsewhere, but not by paying blacks less than whites. An apparent "wage-equity constraint" prevailed, resulting in virtually no racial variation in wages inside Ford. An implication was that blacks quit Ford jobs less often than whites, holding working conditions constant. Arb...

Ford's E-450 H2ICE program

International Nuclear Information System (INIS)

Williams, R.

2006-01-01

In 4th quarter of 2006, Ford delivered the first Hydrogen powered Internal Combustion Engine (ICE) vehicles to customers. Ford is a leader in alternative fuels and engine strategies for future applications, and these vehicles serve as a bridge to Fuel Cell Vehicle acceptance and continued development of the hydrogen economy. This program also supports continued growth in hydrogen fueling infrastructure and vehicle hydrogen storage development. This presentation provided a program summary and discuss some of the lessons learned in dealing with placements of hydrogen powered vehicles. (author)

The Pioneering Legacy of Betty Ford | NIH MedlinePlus the Magazine

Science.gov (United States)

... Ford Photo: AP “Mrs. Ford was a courageous pioneer, a groundbreaking First Lady , and a forceful advocate ... and drug addiction, located next to the Eisenhower Medical Center in Rancho Mirage, California. The facility offers ...

Tom Ford Construction, LLC Information Sheet

Science.gov (United States)

Tom Ford Construction, LLC (the Company) is located in Brentwood, Tennessee. The settlement involves renovation activities conducted at a property constructed prior to 1978, located in Nashville, Tennessee.

75 FR 14192 - Grant of Individual Exemption Involving Ford Motor Company, Located in Detroit, MI

Science.gov (United States)

2010-03-24

... lieu of some or all of the investments in the TAA, (b) two promissory notes issued by Ford in an... commenter's concerns, Ford contends that the fundamental deal reached by the parties is that Ford will make... investment return on the TAA assets paid to Ford in exchange for the TAA Note. Based on year-end returns...

Champion of Cultural Competence: An Interview with Donna Y. Ford

Science.gov (United States)

Henshon, Suzanna E.

2008-01-01

This article presents an interview with Donna Y. Ford, a Professor of Education and Human Development at Vanderbilt University where she teaches in the Department of Special Education. Ford has been a Professor of Special Education at the Ohio State University, an Associate Professor of Educational Psychology at the University of Virginia, and a…

Ford foundation report 'too optimistic' on US uranium supplies

International Nuclear Information System (INIS)

Marshall, P.

1977-01-01

Delegates to the Uranium Institutes London Symposium on supply and demand heard two extremes of opinion over the extent of recovery of uranium reserves from representative of the Ford/Mitre Group and the National Academy of Sciences Panel. The Ford/Mitre group were accused of taking too optimistic a view. A more pessimistic attitude was shown by the Academy studies whose figures for projected annual uranium production, and uranium requirements are quoted. (U.K.)

75 FR 50036 - Petition To Modify an Exemption of a Previously Approved Antitheft Device; Ford Motor Company

Science.gov (United States)

2010-08-16

... Exemption of a Previously Approved Antitheft Device; Ford Motor Company AGENCY: National Highway Traffic..., the National Highway Traffic Safety Administration (NHTSA) granted in full Ford Motor Company's (Ford... Prevention Standard for the Ford Focus vehicle line beginning with model year (MY 2006). On June 18, 2010...

77 FR 35112 - Petition To Modify an Exemption of a Previously Approved Antitheft Device; Ford Motor Company

Science.gov (United States)

2012-06-12

... Exemption of a Previously Approved Antitheft Device; Ford Motor Company AGENCY: National Highway Traffic... Traffic Safety Administration (NHTSA) granted in full Ford Motor Company's (Ford) petition for an... Standard for the Ford Fusion vehicle line beginning with its model year (MY) 2012 vehicles. On February 16...

78 FR 11857 - Agency Information Collection Activities; Comment Request; William D. Ford Federal Direct Loan...

Science.gov (United States)

2013-02-20

...; Comment Request; William D. Ford Federal Direct Loan Program (DL) Regulations AGENCY: Department of... in response to this notice will be considered public records. Title of Collection: William D. Ford.... Abstract: The William D. Ford Federal Direct Loan Program regulations cover areas of program administration...

The Ford Foundation and the rise of behavioralism in political science.

Science.gov (United States)

Hauptmann, Emily

2012-01-01

How did behavioralism, one of the most influential approaches to the academic study of politics in the twentieth century, become so prominent so quickly? I argue that many political scientists have either understated or ignored how the Ford Foundation's Behavioral Sciences Program gave form to behavioralism, accelerated its rise, and helped root it in political science. I then draw on archived documents from Ford as well as one of its major grantees, U. C. Berkeley, to present several examples of how Ford used its funds to encourage the behavioral approach at a time when it had few adherents among political scientists. © 2012 Wiley Periodicals, Inc.

The Ford Partnership for Advanced Studies: A New Case for Curriculum Integration in Technology Education

Science.gov (United States)

Zinser, Richard; Poledink, Paul

2005-01-01

The Ford Motor Company launched a new pre-engineering curriculum for high schools in the Fall of 2004. Building on an earlier manufacturing program, the development process for the Ford Partnership for Advanced Studies took approximately three years. Ford and the course designers wanted the new program to incorporate the best principles and…

Generalized Ford-Vilenkin approach for the dynamical Casimir effect

International Nuclear Information System (INIS)

Rego, Andreson L.C.; Alves, Danilo Teixeira; Alves, Joao Paulo da Silva

2012-01-01

Full text: In the 70s decade the first works investigating the quantum problem of the radiation emitted by moving mirrors in vacuum were published by Moore, DeWitt, Fulling and Davies. This effect, usually named dynamical Casimir effect (DCE). The DCE is also related to several other problems like particle creation in cosmological models and radiation emitted by collapsing black holes, decoherence, entanglement the Unruh effect. The DCE has been subject to experimental investigations: few months ago, Wilson and collaborators have announced the first experimental observation of the DCE. The theory of the DCE has been investigated by many authors, among them Ford and Vilenkin [L.H. Ford and A. Vilenkin, Phys. Rev. D 25, 2569 (1982)] who developed a perturbative method, which can be applied to moving mirrors in small displacements δq(t) = εF (t) and with nonrelativistic velocities. The usual application of the Ford-Vilenkin approach to the calculation of the spectrum of the created particles, results in the spectral distribution proportional to ε 2 . In the present paper, we consider a real massless scalar field and a moving mirror in a two-dimensional spacetime, satisfying Dirichlet boundary condition at the instantaneous position of the mirror, for large displacements and relativistic velocities. We generalize the Ford-Vilenkin approach to the calculation of the spectral density of the created particles, obtaining formulas for the spectrum up to order ε n . (author)

Operating manual for Ford's Farm Range air samplers

International Nuclear Information System (INIS)

Glissmeyer, J.A.; Halverson, M.A.

1980-10-01

An air-sampling program was designed for a target enclosure at the Ford's Farm Range, Aberdeen Proving Ground, Maryland, where the Army test-fires tungsten and depleted-uranium armor penetrators. The primary potential particle inhalation hazard is depleted uranium. The sampling program includes workplace and filtered exhaust air sampling. Conventional isokinetic stack sampling was employed for the filtered exhaust air. Because of the need for rapid monitor response to concentration increases and decreases, conventional radioactive particle monitors were not used. Instead, real-time aerosol monitors employing a light-scattering technique were used for monitors requiring a fast response. For other monitoring functions, piezoelectric and beta-attenuation respirable-particle sampling techniques were used. The application of these technologies to the monitoring of airborne radioactive contaminants is addressed. Sampler installation and operation are detailed

77 FR 43276 - Notice of Proposed Information Collection Requests; Federal Student Aid; William D. Ford Federal...

Science.gov (United States)

2012-07-24

...; William D. Ford Federal Direct Loan Program General Forbearance Request SUMMARY: Borrowers who receive loans through the William D. Ford Federal Direct Loan Program will use this form to request forbearance... considered public records. Title of Collection: William D. Ford Federal Direct Loan Program General...

Factor Analytic Validation of the Ford, Wolvin, and Chung Listening Competence Scale

Science.gov (United States)

Mickelson, William T.; Welch, S. A.

2012-01-01

This research begins to independently and quantitatively validate the Ford, Wolvin, and Chung (2000) Listening Competency Scale. Reliability and Confirmatory Factor analyses were conducted on two independent samples. The reliability estimates were found to be below those reported by Ford, Wolvin, and Chung (2000) and below acceptable levels for…

77 FR 47374 - Notice of Proposed Information Collection Requests; Federal Student Aid; William D. Ford Federal...

Science.gov (United States)

2012-08-08

...; William D. Ford Federal Direct Loan (Direct Loan) Program/ Federal Family Loan (FFEL) Program: Deferment... which borrowers in the William D. Ford Federal Direct Loan (Direct Loan) and Federal Family Education... considered public records. Title of Collection: William D. Ford Federal Direct Loan (Direct Loan) Program...

77 FR 19718 - Ford Motor Company Twin Cities Assembly Plant Vehicle Operations Division Including On-Site...

Science.gov (United States)

2012-04-02

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-81,038] Ford Motor Company Twin... February 9, 2012, applicable to workers of Ford Motor Company, Twin Cities Assembly Plant, Vehicle..., and Pacer International were employed on-site at the St. Paul, Minnesota location of Ford Motor...

75 FR 3252 - Ford Motor Company, Dearborn Truck Plant, Dearborn, MI; Notice of Negative Determination on...

Science.gov (United States)

2010-01-20

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-70,326] Ford Motor Company... workers and former workers of Ford Motor Company, Dearborn Truck Plant, Dearborn, Michigan. The Department... separations were not related to an increase in imports of like or directly competitive products with Ford F...

76 FR 27669 - Automotive Components Holdings, LLC, a Subsidiary of Ford Motor Company, Saline Plant Division...

Science.gov (United States)

2011-05-12

... Holdings, LLC, a Subsidiary of Ford Motor Company, Saline Plant Division, Including Workers Whose Wages Were Reported Under Ford Company, Visteon, MSX International, W.J. O'Neil Company, and Unibar, Saline... workers of Automotive Components Holdings, LLC, a Subsidiary of Ford Motor Company, Saline Plant Division...

Validation of the German version of the Ford Insomnia Response to Stress Test.

Science.gov (United States)

Dieck, Arne; Helbig, Susanne; Drake, Christopher L; Backhaus, Jutta

2018-06-01

The purpose of this study was to assess the psychometric properties of a German version of the Ford Insomnia Response to Stress Test with groups with and without sleep problems. Three studies were analysed. Data set 1 was based on an initial screening for a sleep training program (n = 393), data set 2 was based on a study to test the test-retest reliability of the Ford Insomnia Response to Stress Test (n = 284) and data set 3 was based on a study to examine the influence of competitive sport on sleep (n = 37). Data sets 1 and 2 were used to test internal consistency, factor structure, convergent validity, discriminant validity and test-retest reliability of the Ford Insomnia Response to Stress Test. Content validity was tested using data set 3. Cronbach's alpha of the Ford Insomnia Response to Stress Test was good (α = 0.80) and test-retest reliability was satisfactory (r = 0.72). Overall, the one-factor model showed the best fit. Furthermore, significant positive correlations between the Ford Insomnia Response to Stress Test and impaired sleep quality, depression and stress reactivity were in line with the expectations regarding the convergent validity. Subjects with sleep problems had significantly higher scores in the Ford Insomnia Response to Stress Test than subjects without sleep problems (P Stress Test had significantly lower sleep quality (P = 0.01), demonstrating that vulnerability for stress-induced sleep disturbances accompanies poorer sleep quality in stressful episodes. The findings show that the German version of the Ford Insomnia Response to Stress Test is a reliable and valid questionnaire to assess the vulnerability to stress-induced sleep disturbances. © 2017 European Sleep Research Society.

Structural analysis during the development of the Ford Lion V6 engine; Strukturanalysen bei der Entwicklung des neuen Ford-Lion-V6-Dieselmotors

Energy Technology Data Exchange (ETDEWEB)

Parker, M.J.; Moore, D.S. [Perkins Engines Co., Peterborough (United Kingdom); Gill, S. [Ford Motor Co., Dearborn, MI (United States); Rowley, J. [Ford Motor Co. Ltd., Basildon (United Kingdom)

2006-04-15

Ford and PSA Peugeot Citroen have recently launched their new 2.7 litre Lion V6-HSDI engine for installation into the Jaguar 'S' type platform. The engine was developed to provide market leading noise, vibration and harshness whilst simultaneously providing high power density and meeting the Euro 4 emissions requirements. This paper describes the advanced computer based predictive analysis that was used to support and validate the design of core engine components at each of the individual Ford Product Development System (FPDS) phases for the Lion V6 engine. (orig.)

Fermentering af korn øger fordøjeligheden af næringsstoffer

DEFF Research Database (Denmark)

Pedersen, Anni Øyan; Jørgensen, Henry Johs. Høgh; Knudsen, Knud Erik Bach

2010-01-01

Et fordøjelighedsforsøg har vist, at energiværdien af byg og hvede steg ved fermentering. Effekten var størst ved fermentering af byg, hvor fordøjeligheden af organisk stof for enden af tyndtarmen steg statistisk sikkert med 9 %. Ved fermentering af hvede steg fordøjeligheden af organisk stof...... af vand og dels CO2-produktion og dermed tørstoftab. Anbefaling om beregning af energiværdi i fermenteret korn vil blive foretaget ud fra resultaterne af et produktionsforsøg med slagtesvin, som er under publicering. Fosforudnyttelse i fermenteret korn undersøges yderligere i et produktionsforsøg med...

78 FR 55076 - Ganley Ford West, Inc.; Analysis of Proposed Consent Order To Aid Public Comment

Science.gov (United States)

2013-09-09

... FEDERAL TRADE COMMISSION [File No. 122 3269] Ganley Ford West, Inc.; Analysis of Proposed Consent... for Comment part of the SUPPLEMENTARY INFORMATION section below. Write ``Ganley Ford, File No. 122... receive it on or before October 3, 2013. Write ``Ganley Ford, File No. 122 3269'' on your comment. Your...

76 FR 21637 - Safety Zone; Ford Estate Wedding Fireworks, Lake St. Clair, Grosse Pointe Shores, MI

Science.gov (United States)

2011-04-18

...-AA00 Safety Zone; Ford Estate Wedding Fireworks, Lake St. Clair, Grosse Pointe Shores, MI AGENCY: Coast... portion of Lake St. Clair River during the Ford Estate Wedding Fireworks. DATES: This rule is effective... vessels during the setup, loading, and launching of the Ford Estate Wedding Fireworks Display. The...

Development of Ford Island, Pearl Harbor, Hawaii

National Research Council Canada - National Science Library

Granetto, Paul

1994-01-01

.... The DoD Hotline complaint alleged that the Navy was not receiving the fair market value for the land, the Navy was understating the estimated cost to construct the causeway and to develop Ford Island...

Ford Class Aircraft Carrier: Poor Outcomes Are the Predictable Consequences of the Prevalent Acquisition Culture

Science.gov (United States)

2015-10-01

FORD CLASS AIRCRAFT CARRIER Poor Outcomes Are the Predictable Consequences of the Prevalent Acquisition Culture...2. REPORT TYPE 3. DATES COVERED 00-00-2015 to 00-00-2015 4. TITLE AND SUBTITLE Ford Class Aircraft Carrier: Poor Outcomes Are the Predictable...This Study The Navy set ambitious goals for the Ford -class program, including an array of new technologies and design features that were intended

Environmental Assessment for Ford Island Conference Center, Pearl Harbor Naval Complex, O'ahu, Hawaii

National Research Council Canada - National Science Library

2004-01-01

... (formerly the Ford Island Theater), a historic property, at Ford Island, Oahu, Hawaii. The Proposed Action would have an adverse effect on Building 89 due to its partial demolition and alterations to the interior...

78 FR 77397 - Flood Control Regulations, Marshall Ford Dam (Mansfield Dam and Lake Travis), Colorado River, Texas

Science.gov (United States)

2013-12-23

... Regulations, Marshall Ford Dam (Mansfield Dam and Lake Travis), Colorado River, Texas AGENCY: U.S. Army Corps... Marshall Ford Dam (Mansfield Dam and Lake Travis), Colorado River, Texas. In 1997, the Lower Colorado River... regulations to reflect changes in ownership and responsibilities of flood control management of Marshall Ford...

78 FR 36792 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Ford Motor...

Science.gov (United States)

2013-06-19

... Production Act of 1993--Ford Motor Company and General Motors Holdings LLC Collaboration Notice is hereby... Production Act of 1993, 15 U.S.C. 4301 et seq. (``the Act''), Ford Motor Company and General Motors Holdings LLC Collaboration (``Ford and GM'') has filed written notifications simultaneously with the Attorney...

33 CFR 208.19 - Marshall Ford Dam and Reservoir (Mansfield Dam and Lake Travis), Colorado River, Tex.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Marshall Ford Dam and Reservoir... Marshall Ford Dam and Reservoir (Mansfield Dam and Lake Travis), Colorado River, Tex. The Secretary of the Interior, through his agent, the Lower Colorado River Authority (LCRA) shall operate the Marshall Ford Dam...

77 FR 40515 - Safety Zone; Detroit Symphony Orchestra at Ford House Fireworks, Lake St. Clair, Grosse Pointe...

Science.gov (United States)

2012-07-10

...-AA00 Safety Zone; Detroit Symphony Orchestra at Ford House Fireworks, Lake St. Clair, Grosse Pointe... Detroit Symphony Orchestra at the Ford House Fireworks. This zone will be effective and enforced from 10.... 165.T09-0600 Safety Zone; Detroit Symphony Orchestra at Ford House Fireworks, Lake St. Clair, Grosse...

Corporate ergonomics programme at Ford Motor Company.

Science.gov (United States)

Joseph, Bradley S

2003-01-01

The use of ergonomic principles in automobile assembly and manufacturing operations has become an important part of a comprehensive health and safety process as well as an integral part of the engineering systems. Ford Motor Company has developed an ergonomics process to manage issues related to injury and illness (e.g., musculoskeletal diseases) and to ensure the appropriate use of human resources on the plant floor. The ergonomics programme uses joint labour and management teams to identify and evaluate jobs and develop and implement solutions. This paper summarises the efforts of the Ford Motor Company in implementing and maintaining the programme. Key strategies are outlined that provide important links to internal organisational units that are critical to fully utilise the ergonomics process. In addition, the paper outlines differences between proactive and reactive efforts and shows the importance of using the information generated by the initiatives for process improvement.

Driving change: an interview with Ford Motor Company's Jacques Nasser. Interview by Suzy Wetlaufer.

Science.gov (United States)

Nasser, J

1999-01-01

What happens when the world is changing but your organization isn't? And what if that organization has 340,000 employees in 200 countries? In this interview, Jacques Nasser, the new CEO of Ford Motor Company, talks with HBR editor Suzy Wetlaufer about these challenges and explains how his company is overcoming them through a unique education program. Since its very beginnings, says Nasser, Ford has comprised dozens of far-flung divisions and units, each with its own "fiefdom" mind-set. The fiefdoms didn't share information, let alone great ideas. Such behavior stifled creativity and drove up costs. Today's global environment demands a new and different way of doing business, says Nasser, and to that end, Ford has launched a multifaceted teaching initiative that will reach every one of Ford's employees by year-end. The goal of the program: to help employees view the company in its entirety as shareholders do, and then act that way too. At the heart of the initiative is the teachable point of view, a five-part written explanation of what a person knows and believes about what it takes to succeed in business. It is more than just a document to be discussed and then filed. It has proven to be a powerful tool for organizational transformation, and not only at Ford. In a commentary accompanying Nasser's interview, Noel Tichy, leadership expert and consultant to Ford describes the building blocks of the teachable point of view and explores how it can be implemented in any organization determined to change for the better.

Bellman Ford algorithm - in Routing Information Protocol (RIP)

Science.gov (United States)

Krianto Sulaiman, Oris; Mahmud Siregar, Amir; Nasution, Khairuddin; Haramaini, Tasliyah

2018-04-01

In a large scale network need a routing that can handle a lot number of users, one of the solutions to cope with large scale network is by using a routing protocol, There are 2 types of routing protocol that is static and dynamic, Static routing is manually route input based on network admin, while dynamic routing is automatically route input formed based on existing network. Dynamic routing is efficient used to network extensively because of the input of route automatic formed, Routing Information Protocol (RIP) is one of dynamic routing that uses the bellman-ford algorithm where this algorithm will search for the best path that traversed the network by leveraging the value of each link, so with the bellman-ford algorithm owned by RIP can optimize existing networks.

77 FR 58819 - Notice of Submission for OMB Review; Federal Student Aid; William D. Ford Federal Direct Loan...

Science.gov (United States)

2012-09-24

... DEPARTMENT OF EDUCATION Notice of Submission for OMB Review; Federal Student Aid; William D. Ford... William D. Ford Federal Direct Loan Program will use this form to request forbearance on their loans when... of Collection: William D. Ford Federal Direct Loan Program General Forbearance Request. OMB Control...

77 FR 29988 - Notice of Submission for OMB Review; Federal Student Aid; William D. Ford Federal Direct Loan...

Science.gov (United States)

2012-05-21

... DEPARTMENT OF EDUCATION Notice of Submission for OMB Review; Federal Student Aid; William D. Ford... borrowers in the William D. Ford Federal Direct Loan (Direct Loan) and Federal Family Education Loan (FFEL... of Collection: William D. Ford Federal Direct Loan Program Deferment Request Forms. OMB Control...

Øget NDF fordøjelighed i grovfoderet øger mælkeproduktionen

DEFF Research Database (Denmark)

Lehmann, J O; Thøgersen, R; Weisbjerg, Martin Riis

2010-01-01

En stigning på ét procentpoint i grovfoderets NDF fordøjelighed medførte en ydelsesstigning på 0,25 kg EKM pr. ko pr. dag i et produktionsforsøg med majsensilage på Forskningscenter Foulum. I forsøget varierede fordøjeligheden af NDF i majs, høsttidspunktet for majsen, samt hvorvidt grovfoderet...

75 FR 34526 - Ford Petition for Exemption From the Vehicle Theft Prevention Standard; Correction

Science.gov (United States)

2010-06-17

... Exemption From the Vehicle Theft Prevention Standard; Correction AGENCY: National Highway Traffic Safety..., granting in full Ford Motor Company's (Ford) petition for an exemption of its new Explorer vehicle line in accordance with 49 CFR part 543, Exemption from the Theft Prevention Standard. This document corrects certain...

President Ford and both the Soviet and American ASTP crews

Science.gov (United States)

1974-01-01

President Gerald R. Ford removes the Soviet Soyuz spacecraft model from a model set depicting the 1975 Apollo Soyuz Test Project (ASTP), an Earth orbital docking and rendezvous mission with crewmen from the U.S. and USSR. From left to right, Vladamir A. Shatalov, Chief, Cosmonaut training; Valeriy N. Kubasov, ASTP Soviet engineer; Aleksey A. Leonov, ASTP Soviet crew commander; Thomas P. Stafford, commander of the American crew; Donald K. Slayton, American docking module pilot; Vance D. Brand, command module pilot for the American crew. Dr. George M Low, Deputy Administrator for NASA is partially obscured behind President Ford.

Completion evaluation of the Eagle Ford formation with heterogeneous proppant placement

Energy Technology Data Exchange (ETDEWEB)

Viswanathan, A.; Altman, R.; Oussoltsev, D.; Kanneganti, K.; Xu, J.; Grant, D.; Indriati, S.; Pena, A.; Loayza, M.; Kirkham, B.; Rhein, T. [Society of Petroleum Engineers (Canada)

2011-07-01

With the major developments of the Eagle Ford shale in Texas, there has been an increasing focus on the optimization of stimulation techniques. Many techniques have already been implemented in order to improve productivity across Eagle Ford. This paper analyzes completion techniques currently in place through the Hawkville field with the goal of determining key parameters and their impact on the well. The paper focuses mainly on channel fracturing based on a heterogeneous proppant placement technique and evaluates it against current slickwater and hybrid stimulation treatments. The evaluation described in the paper was conducted by first collecting data from 51 horizontal wells in the Eagle Ford formation. It then follows through the evaluation completing a normalized production comparison, a productivity index analysis, neural network trained self-organizing maps, and numerical simulations. Through evaluations and comparisons the paper shows that channel fracturing can allow for a significant improvement in production of dry gas wells.

Critique of the Ford-Andresen film rupture model for aqueous stress corrosion cracking

International Nuclear Information System (INIS)

Hall, M.M.

2009-01-01

The Ford-Andresen film rupture model for aqueous stress corrosion cracking has obtained a prominent position in the nuclear reactor industry. The model is said to have superior predictive capabilities because it is derived from a fundamental understanding of the film rupture-repassivation mechanism of crack advance. However, a critical review shows that there are conceptual and mathematical problems with the Ford-Andresen model development; there are inconsistencies among the stated and implied assumptions, the crack tip current density expression lacks the necessary dependence on crack tip strain rate and the fundamental proportionality that exists between crack tip strain rate and crack growth rate is overlooked and omitted from the model development. Consequently, the Ford-Andresen model must be considered neither phenomenologically nor fundamentally supported.

78 FR 45515 - Agency Information Collection Activities; Comment Request; William D. Ford Federal Direct Loan...

Science.gov (United States)

2013-07-29

... DEPARTMENT OF EDUCATION [Docket No.: ED-2013-ICCD-0099] Agency Information Collection Activities; Comment Request; William D. Ford Federal Direct Loan Program Repayment Plan Selection Form AGENCY... notice will be considered public records. Title of Collection: William D. Ford Federal Direct Loan...

Theoretical Foundation for Electric-Dipole-Allowed Chiral-Specific Fluorescence Optical Rotary Dispersion (F-ORD) from Interfacial Assemblies.

Science.gov (United States)

Deng, Fengyuan; Ulcickas, James R W; Simpson, Garth J

2016-11-03

Fluorescence optical rotary dispersion (F-ORD) is proposed as a novel chiral-specific and interface-specific spectroscopic method. F-ORD measurements of uniaxial assemblies are predicted to be fully electric-dipole-allowed, with corresponding increases in sensitivity to chirality relative to chiral-specific measurements in isotropic assemblies that are commonly interpreted through coupling between electric and magnetic dynamic dipoles. Observations of strong chiral sensitivity in prior single-molecule fluorescence measurements of chiral interfacial molecules are in excellent qualitative agreement with the predictions of the F-ORD mechanism and challenging to otherwise explain. F-ORD may provide methods to suppress background fluorescence in studies of biological interfaces, as the detected signal requires both polar local order and interfacial chirality. In addition, the molecular-level descriptions of the mechanisms underpinning F-ORD may also potentially apply to aid in interpreting chiral-specific Raman and surface-enhanced Raman spectroscopy measurements of uniaxially oriented assemblies, opening up opportunities for chiral-specific and interface-specific vibrational spectroscopy.

78 FR 52169 - Agency Information Collection Activities; Comment Request; William D. Ford Federal Direct Loan...

Science.gov (United States)

2013-08-22

... DEPARTMENT OF EDUCATION [Docket No. ED-2013-ICCD-0109] Agency Information Collection Activities; Comment Request; William D. Ford Federal Direct Loan (Direct Loan) Program Federal Direct PLUS Loan Master... to this notice will be considered public records. Title of Collection: William D. Ford Federal Direct...

Ford: Not a Lincoln but a Hayes? A Lesson in History and Political Science

Science.gov (United States)

Donnangelo, John A.

2007-01-01

History or social studies teachers are constantly striving to make the past come alive for their students and to help them see that not only does the past relate to the present, but it can also give insights into the future. The recent passing of former President Gerald R. Ford provides social studies teachers with just such an opportunity. Ford's…

The 'Overly-Broad' Selden Patent, Henry Ford and Development in the Early US Automobile Industry

DEFF Research Database (Denmark)

Howells, John; Katznelson, Ron D

of the Selden patent claims. We use new primary sources to show how Henry Ford and others engaged in what today is called “Freedom to Operate” patent analysis when it most mattered commercially. We show that Ford correctly anticipated that a future court adjudication of the Selden patent claims would...

77 FR 58818 - Notice of Proposed Information Collection Requests; Federal Student Aid; William D. Ford Federal...

Science.gov (United States)

2012-09-24

... DEPARTMENT OF EDUCATION Notice of Proposed Information Collection Requests; Federal Student Aid; William D. Ford Federal Direct Loan Program Regulations-- Servicemembers Civil Relief Act SUMMARY: Upon a... in response to this notice will be considered public records. Title of Collection: William D. Ford...

Energy Intensity and Greenhouse Gas Emissions from Oil Production in the Eagle Ford Shale

Energy Technology Data Exchange (ETDEWEB)

Yeh, Sonia; Ghandi, Abbas; Scanlon, Bridget R.; Brandt, Adam R.; Cai, Hao; Wang, Michael Q.; Vafi, Kourosh; Reedy, Robert C.

2017-01-30

A rapid increase in horizontal drilling and hydraulic fracturing in shale and “tight” formations that began around 2000 has resulted in record increases in oil and natural gas production in the U.S. This study examines energy consumption and greenhouse gas (GHG) emissions from crude oil and natural gas produced from ~8,200 wells in the Eagle Ford Shale in southern Texas from 2009 to 2013. Our system boundary includes processes from primary exploration wells to the refinery entrance gate (henceforth well-to-refinery or WTR). The Eagle Ford includes four distinct production zones—black oil (BO), volatile oil (VO), condensate (C), and dry gas (G) zones—with average monthly gas-to-liquids ratios (thousand cubic feet per barrel—Mcf/bbl) varying from 0.91 in the BO zone to 13.9 in the G zone. Total energy consumed in drilling, extracting, processing, and operating an Eagle Ford well is ~1.5% of the energy content of the produced crude and gas in the BO and VO zones, compared with 2.2% in the C and G zones. On average, the WTR GHG emissions of gasoline, diesel, and jet fuel derived from crude oil produced in the BO and VO zones in the Eagle Ford play are 4.3, 5.0, and 5.1 gCO2e/MJ, respectively. Comparing with other known conventional and unconventional crude production where upstream GHG emissions are in the range 5.9–30 gCO2e/MJ, oil production in the Eagle Ford has lower WTR GHG emissions.

Leslie Ford, MD | Division of Cancer Prevention

Science.gov (United States)

Dr. Leslie Ford built clinical cancer prevention research as a scientific field when few people were considering the possibility of prevention, and is recognized as a national and international leader in cancer prevention research. She has a passion for prevention and strong belief that all clinical science must, to the fullest extent possible, derive as a translation of basic

76 FR 88 - Voluntary Termination of Foreign-Trade Subzone 102A, Ford Motor Corporation, Hazelwood, MO

Science.gov (United States)

2011-01-03

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [Order No. 1728] Voluntary Termination of Foreign-Trade Subzone 102A, Ford Motor Corporation, Hazelwood, MO Pursuant to the authority granted in the... the Ford Motor Corporation plant in Hazelwood, Missouri (Board Order 252, 49 FR 19541, 5/8/84...

Geochemical and mineralogical characterization of the Eagle Ford Shale: Results from the USGS Gulf Coast #1 West Woodway core

Science.gov (United States)

Birdwell, Justin E.; Boehlke, Adam; Paxton, Stanley T.; Whidden, Katherine J.; Pearson, Ofori N.

2017-01-01

The Eagle Ford shale is a major continuous oil and gas resource play in southcentral Texas and a source for other oil accumulations in the East Texas Basin. As part of the U.S. Geological Survey’s (USGS) petroleum system assessment and research efforts, a coring program to obtain several immature, shallow cores from near the outcrop belt in central Texas has been undertaken. The first of these cores, USGS Gulf Coast #1 West Woodway, was collected near Waco, Texas, in September 2015 and has undergone extensive geochemical and mineralogical characterization using routine methods to ascertain variations in the lithologies and chemofacies present in the Eagle Ford at this locale. Approximately 270 ft of core was examined for this study, focusing on the Eagle Ford Group interval between the overlying Austin Chalk and underlying Buda Limestone (~20 ft of each). Based on previous work to identify the stratigraphy of the Eagle Ford Group in the Waco area and elsewhere (Liro et al., 1994; Robison, 1997; Ratcliffe et al., 2012; Boling and Dworkin, 2015; Fairbanks et al., 2016, and references therein), several lithological units were expected to be present, including the Pepper Shale (or Woodbine), the Lake Waco Formation (or Lower Eagle Ford, including the Bluebonnet, Cloice, and Bouldin or Flaggy Cloice members), and the South Bosque Member (Upper Eagle Ford). The results presented here indicate that there are three major chemofacies present in the cored interval, which are generally consistent with previous descriptions of the Eagle Ford Group in this area. The relatively high-resolution sampling (every two ft above the Buda, 432.8 ft depth, and below the Austin Chalk, 163.5 ft depth) provides great detail in terms of geochemical and mineralogical properties supplementing previous work on immature Eagle Ford Shale near the outcrop belt.

The Impact of the Ford Fellowship Program in the Creation of Latina/o Academic Generations

Science.gov (United States)

Velez-Ibanez, Carlos; Szecsy, Elsie; Pena, Courtney

2013-01-01

On October 18, 2003, one of the authors had the privilege of giving one of the keynote speeches to the Ford Foundation Fellows Conference in San Juan, Puerto Rico, that was titled "The Making of a Ford Fellow: A Trek Towards Excellence in Applied Social Science," which explained that he managed to develop some of the ideas that led to the…

77 FR 2605 - Public Notice for Waiver of Aeronautical Land-Use Assurance; Gerald R. Ford International Airport...

Science.gov (United States)

2012-01-18

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Public Notice for Waiver of Aeronautical Land-Use Assurance; Gerald R. Ford International Airport, Grand Rapids, MI AGENCY: Federal... this FAA action may be reviewed at this same location or at Gerald R. Ford International Airport, Grand...

78 FR 63464 - William D. Ford Federal Direct Loan Program Repayment Plan Selection Form; Extension of Public...

Science.gov (United States)

2013-10-24

... DEPARTMENT OF EDUCATION William D. Ford Federal Direct Loan Program Repayment Plan Selection Form; Extension of Public Comment Period; Correction AGENCY: Department of Education. ACTION: Correction notice... entitled, ``William D. Ford Federal Direct Loan Program Repayment Plan Selection Form''. ED is extending...

Assisted suicide and assisted voluntary euthanasia: Stransham-Ford ...

African Journals Online (AJOL)

The decision in Stransham-Ford v Minister of Justice and Correctional. Services and Others[1] by the North Gauteng High Court held that a terminally ill patient with intractable suffering was entitled to commit suicide with the assistance of his doctor, whose conduct would not be unlawful. The evidence was that the applicant ...

Analýza sortimentu společnosti Ford Motor Company s.r.o.

OpenAIRE

Bencová, Petra

2013-01-01

This thesis analyzes the products of Ford Motor Company s.r.o. which is a company operating on the Czech car market. The work is based on the theoretical knowledge described in the first part. The first part is followed by a practical section, in which I first describe the current market situation in the automotive industry in Czech Republic. Further I characterize the company Ford Motor Company s.r.o. itself, then I describe the most important car models and related market segments. Later in...

Geologic and Engineering Characterization of East Ford Field, Reeves County, Texas

Energy Technology Data Exchange (ETDEWEB)

Dutton, Shirley P.; Flanders, William A.; Guzman, Jose I.; Zirczy, Helena

1999-08-16

The objective of this Class III project is to demonstrate that detailed reservoir characterization of slope and basin clastic reservoirs in sandstones of the Delaware Mountain Group in the Delaware Basin of West Texas and New Mexico is a cost-effective way to recover a higher percentage of the original oil in place through geologically based field development. The project focused on reservoir characterization of the East Ford unit, a representative Delaware Mountain Group field that produces from the upper Bell Canyon Formation (Ramsey Sandstone). The field, discovered in 1960, is operated by Oral Petco, Inc., as the East Ford unit: it contained an estimated 18.4 million barrels (MMbbl) of original oil in place.

Isotropic cosmic expansion and the Rubin-Ford effect

International Nuclear Information System (INIS)

Fall, S.M.; Jones, B.J.T.

1976-01-01

It is shown that the Rubin-Ford data (Astrophys. J. Lett. 183:L111 (1973)), often taken as evidence for large scale anisotropic cosmic expansion, probably only reflect the inhomogeneous distribution of galaxies in the region of the sample. The data presented are consistent with isotropic expansion, an unperturbed galaxy velocity field, and hence a low density Universe. (author)

Fast Forward: An Upskilling Programme for Ford Motor Company Foundry Workers.

Science.gov (United States)

Cousin, Glynis; Pound, Gill

1991-01-01

The purpose of an upgrading program for British Ford Motor Company employees was getting trainees back into learning environments and improving communication, listening, calculation, reading, and cooperation. (SK)

Ford Hatchery; Washington Department of Fish and Wildlife Fish Program, Hatcheries Division, Annual Report 2003.

Energy Technology Data Exchange (ETDEWEB)

Lovrak, Jon; Ward, Glen

2004-01-01

Bonneville Power Administration's participation with the Washington Department of Fish and Wildlife, Ford Hatchery, provides the opportunity for enhancing the recreational and subsistence kokanee fisheries in Banks Lake. The artificial production and fisheries evaluation is done cooperatively through the Spokane Hatchery, Sherman Creek Hatchery (WDFW), Banks Lake Volunteer Net Pen Project, and the Lake Roosevelt Fisheries Evaluation Program. Ford Hatchery's production, together with the Sherman Creek and the Spokane Tribal Hatchery, will contribute to an annual goal of one million kokanee yearlings for Lake Roosevelt and 1.4 million kokanee fingerlings and fry for Banks Lake. The purpose of this multi-agency program is to restore and enhance kokanee salmon and rainbow trout populations in Lake Roosevelt and Banks Lake due to Grand Coulee Dam impoundments. The Ford Hatchery will produce 9,533 lbs. (572,000) kokanee annually for release as fingerlings into Banks Lake in October. An additional 2,133 lbs. (128,000) kokanee will be transferred to net pens on Banks Lake at Electric City in October. The net pen raised kokanee will be reared through the fall, winter, and early spring to a total of 8,533 lbs and released in May. While the origin of kokanee comes from Lake Whatcom, current objectives will be to increase the use of native (or, indigenous) stocks for propagation in Banks Lake and the Upper Columbia River. Additional stocks planned for future use in Banks Lake include Lake Roosevelt kokanee and Meadow Creek kokanee. The Ford Hatchery continues to produce resident trout (80,584 lb. per year) to promote the sport fisheries in trout fishing lakes in eastern Washington (WDFW Management, Region 1). Operation and maintenance funding for the increased kokanee program was implemented in FY 2001 and scheduled to continue through FY 2010. Funds from BPA allow for an additional employee at the Ford Hatchery to assist in the operations and maintenance associated

77 FR 66087 - Federal Perkins Loan Program, Federal Family Education Loan Program, and William D. Ford Federal...

Science.gov (United States)

2012-11-01

..., and 685 Federal Perkins Loan Program, Federal Family Education Loan Program, and William D. Ford... 685 RIN 1840-AD05 [Docket ID ED-2012-OPE-0010] Federal Perkins Loan Program, Federal Family Education... (Perkins Loan) program, Federal Family Education Loan (FFEL) program, and William D. Ford Federal Direct...

78 FR 33395 - Annual Updates to the Income Contingent Repayment (ICR) Plan Formula for 2013-William D. Ford...

Science.gov (United States)

2013-06-04

... DEPARTMENT OF EDUCATION Annual Updates to the Income Contingent Repayment (ICR) Plan Formula for 2013--William D. Ford Federal Direct Loan Program Catalog of Federal Domestic Assistance (CFDA) Number... free, at 1- 800-877-8339. SUPPLEMENTARY INFORMATION: Under the William D. Ford Federal Direct Loan...

77 FR 76414 - William D. Ford Federal Direct Loan Program

Science.gov (United States)

2012-12-28

... Federal Direct Loan Program AGENCY: Department of Education. ACTION: Final regulations; correction... Loan (Perkins Loan) Program; the Federal Family Education Loan (FFEL) Program; and the William D. Ford Federal Direct Loan (Direct Loan) Program, including the Public Service Loan Forgiveness (PSLF) Program...

Effectiveness of Ford's belt reminder system in increasing seat belt use

OpenAIRE

Williams, A; Wells, J; Farmer, C

2002-01-01

Objectives: The study investigated the effectiveness in increasing seat belt use of Ford's belt reminder system, a supplementary system that provides intermittent flashing lights and chimes for five minutes if drivers are not belted.

77 FR 30266 - Annual Updates to the Income Contingent Repayment (ICR) Plan Formula for 2012; William D. Ford...

Science.gov (United States)

2012-05-22

... DEPARTMENT OF EDUCATION Annual Updates to the Income Contingent Repayment (ICR) Plan Formula for 2012; William D. Ford Federal Direct Loan Program AGENCY: Federal Student Aid, Department of Education... announces the annual updates to the ICR plan formula for 2012. Under the William D. Ford Federal Direct Loan...

77 FR 20796 - Annual Updates to the Income Contingent Repayment (ICR) Plan Formula for 2011; William D. Ford...

Science.gov (United States)

2012-04-06

... DEPARTMENT OF EDUCATION Annual Updates to the Income Contingent Repayment (ICR) Plan Formula for 2011; William D. Ford Federal Direct Loan Program AGENCY: Federal Student Aid, Department of Education... announces the annual updates to the ICR plan formula for 2011. Under the William D. Ford Federal Direct Loan...

77 FR 72960 - William D. Ford Federal Direct Loan Program

Science.gov (United States)

2012-12-07

... Federal Direct Loan Program AGENCY: Office of Postsecondary Education, Department of Education. ACTION... document to establish the date for the early implementation of William D. Ford Federal Direct Loan (Direct Loan) program regulations that establish a new income-contingent repayment plan based on the President...

Ford Taurus Ethanol-Fueled Sedan

International Nuclear Information System (INIS)

Eudy, Leslie

1999-01-01

The U.S. Department of Energy (DOE) is encouraging the use of alternative fuels and alternative fuel vehicles (AFVs). To support this activity, DOE has directed the National Renewable Energy Laboratory (NREL) to conduct projects to evaluate the performance and acceptability of light-duty AFVs. In this study, we tested a pair of 1998 Ford Tauruses: one E85 (85% gasoline/15% ethanol) model (which was tested on both E85 and gasoline) and a gasoline model as closely matched as possible. Each vehicle was run through a series of tests to evaluate acceleration, fuel economy, braking, and cold-start capabilities, as well as more subjective performance indicators such as handling, climate control, and noise

Capital estrangeiro e agricultura na Amazônia: a experiência da Ford Motor Company (1922-1945)

OpenAIRE

Costa, Francisco de Assis

2012-01-01

O objetivo deste trabalho é a reconstituição histórica da Companhia Ford Industrial do Brasil entendida, de um lado, como um momento do processo de concentração e centralização do capital empreendido pela Ford Motor Company enquanto parcela individual do capital global; de outro, como forma especifica de materialização deste processo.

Neutronic analysis of the ford nuclear reactor leu core

International Nuclear Information System (INIS)

Raza, S.S.; Hayat, T.

1989-08-01

Neutronic analysis of the ford nuclear reactor low enriched uranium core has been carried out to gain confidence in the com puting methodology being used for Pakistan Research Reactor-1 core conversion calculations. The computed value of the effective multiplication factor (Keff) is found to be in good agreement with that quoted by others. (author). 6 figs

Fordlândia e Belterra: as cidades de Henry Ford na Amazônia

OpenAIRE

Duarte Jr., Antonio Marcos; UERJ & Ibmec/RJ

2015-01-01

Ao final de 1945, a Ford Motor Company apresenta sérios problemas de gestão. Nesse contexto, Henry Ford II precisa decidir o que fazer com Fordlândia e Belterra, as duas problemáticas cidades construídas por seu avô na Amazônia brasileira.O caso foi elaborado para utilização em disciplinas na área de finanças corporativas, abordando temas relacionados a análise econômica e de riscos presentes em projetos de investimento.  Pode ser interessante também em diferentes disciplinas que tratem de te...

Determination of the neutron flux for the Yankee Rowe experiment in the Ford Nuclear Reactor

International Nuclear Information System (INIS)

Cacciapouti, R.J.; Petrusha, L.

1994-01-01

Yankee Atomic Electric Company undertook a Test Irradiation Program at the Ford Nuclear Reactor of the University of Michigan. The program was implemented to characterize the irradiation response of representative Yankee Rowe reactor vessel beltline plate materials. The program was also intended to remove uncertainties in the existing reactor vessel fluence and damage predictions on the Yankee Rowe reactor vessel steel. Since this is the first in-core experiment of this type for the Ford Nuclear Reactor, the measurement of the reaction rate and the estimate of the fluence are presented

Ford F250 Dedicated CNG Pickup

International Nuclear Information System (INIS)

Eudy, Leslie

1999-01-01

The U.S. Department of Energy (DOE) is encouraging the use of alternative fuels and alternative fuel vehicles (AFVs). To support this activity, DOE has directed the National Renewable Energy Laboratory (NREL) to conduct projects to evaluate the performance and acceptability of light-duty AFVs. In this study, we tested a pair of 1998 Ford F-250 pickups: one dedicated compressed natural gas (CNG) model and a gasoline model as closely matched as possible. Each vehicle was run through a series of tests to evaluate acceleration, fuel economy, braking, and cold-start capabilities, as well as more subjective performance indicators such as handling, climate control, and noise

External Financing of Foreign Study: The Ford Foundation in Peru.

Science.gov (United States)

Myers, Robert G.

1983-01-01

The Ford Foundation provided postgraduate scholarships for approximately 12,000 people from Africa, Asia, Latin America, and the Middle East to study abroad between 1960 and 1980. A case study of Peruvian recipients shows how shifts in national policies and international events affected how those trained abroad made use of their experience. (IS)

Identifying At-Risk Individuals for Insomnia Using the Ford Insomnia Response to Stress Test

Science.gov (United States)

Kalmbach, David A.; Pillai, Vivek; Arnedt, J. Todd; Drake, Christopher L.

2016-01-01

Study Objectives: A primary focus of the National Institute of Mental Health's current strategic plan is “predicting” who is at risk for disease. As such, the current investigation examined the utility of premorbid sleep reactivity in identifying a specific and manageable population at elevated risk for future insomnia. Methods: A community-based sample of adults (n = 2,892; 59.3% female; 47.9 ± 13.3 y old) with no lifetime history of insomnia or depression completed web-based surveys across three annual assessments. Participants reported parental history of insomnia, demographic characteristics, sleep reactivity on the Ford Insomnia in Response to Stress Test (FIRST), and insomnia symptoms. DSM-IV diagnostic criteria were used to determine insomnia classification. Results: Baseline FIRST scores were used to predict incident insomnia at 1-y follow-up. Two clinically meaningful FIRST cutoff values were identified: FIRST ≥ 16 (sensitivity 77%; specificity 50%; odds ratio [OR] = 2.88, P insomnia onset, even after controlling for stress exposure and demographic characteristics. Of the incident cases, insomniacs with highly reactive sleep systems reported longer sleep onset latencies (FIRST ≥ 16: 65 min; FIRST ≥ 18: 68 min) than participants with nonreactive insomnia (FIRST insomnia based on trait sleep reactivity. The FIRST accurately identifies a focused target population in which the psychobiological processes complicit in insomnia onset and progression can be better investigated, thus improving future preventive efforts. Citation: Kalmbach DA, Pillai V, Arnedt JT, Drake CL. Identifying at-risk individuals for insomnia using the ford insomnia response to stress test. SLEEP 2016;39(2):449–456. PMID:26446111

Edificio para la Libbey-Owens-Ford Glass Company

Directory of Open Access Journals (Sweden)

Skidmore, Owings & Merrill, Arquitectos

1965-04-01

Full Text Available This is a 15 storey building, located in Toledo, Ohio, and will house the general offices of the Libbey-Owens-Ford Company. There is a basement, which contains air conditioning equipment, stores, service rooms, and similar facilities. The ground floor occupies a smaller area than the floors above, and the difference in area provides a covered arcade round the building. The main hall and lift shafts take up most of the ground floor space. All the remaining storeys are devoted to offices. This is a good example of contemporary functional architecture and also an exciting manifestation of the use of glass in this type of buildings.Este edificio, de 15 plantas de altura, construido en Toledo, Ohio, para oficinas generales de la Libbey-Owens- Ford Glass Company, consta de: un sótano destinado a albergar los equipos mecánicos para el acondicionamiento de aire, etc., almacén, departamentos de servicio, etc. El cuerpo de edificación de la planta baja, que aparece retranqueado de los soportes perimetrales creando una zona porticada, aloja el vestíbulo principal, núcleo de comunicaciones verticales, etcétera. Las restantes plantas están ocupadas por oficinas. No solamente este edificio es un destacado ejemplo de arquitectura moderna, sino que también es una suscitante manifestación de las ideas arquitectónicas en cristal.

Minority and female training programs at the Ford Nuclear Reactor, University of Michigan

International Nuclear Information System (INIS)

Burn, R.R.

1992-01-01

Nuclear power industry operations staffs are composed predominantly of white males because most of the personnel come from the nuclear submarine and surface branches of the U.S. Navy. The purpose of the minority and female training programs sponsored by the Ford Nuclear Reactor at the University of Michigan is to provide a path for minorities and women to enter the nuclear industry as operators, technicians, and, in the long term, as graduate engineers. The training programs are aimed at high school students, preferably juniors. While the training is directed toward operation of a nuclear reactor, it is equally applicable to careers in most other technical fields. It is hoped that some of the participants will remain at the Ford Nuclear Reactor as reactor operators, enter college, and obtain college degrees, after which they will enter the nuclear industry as graduate engineers

Overview of superplastic forming research at ford motor company

Science.gov (United States)

Friedman, P. A.; Luckey, S. G.; Copple, W. B.; Allor, R.; Miller, C. E.; Young, C.

2004-12-01

In an effort to reduce vehicle weight, the automotive industry has switched to aluminum sheet for many closure panels. Although the application of aluminum is compatible with existing manufacturing processes and has attractive qualities such as low density, good mechanical properties, and high corrosion resistance, it has less room-temperature formability than steel. The expanded forming limits that are possible with superplastic forming can significantly improve the ability to manufacture complex shapes from materials with limited formability. Aluminum closure panels produced by superplastic forming have been used by Ford Motor Company for over a decade. However, applications have been limited to low-volume, specialty vehicles due to the relatively slow cycle time and the cost penalty associated with the specially processed sheet alloys. While there has been substantial research on the superplastic characteristics of aluminum alloys, the bulk of this work has focused on the development of aerospace alloys, which are often too costly and perhaps inappropriate for automotive applications. Additionally, there has been a limited amount of work done to develop the technologies required to support the higher production volumes of the automotive industry. This work presents an automotive perspective on superplastic forming and an overview of the research being performed at Ford Motor Company to increase the production volume so superplastic forming can be cost competitive with more traditional forming technologies.

Building Local Capacity to Bring Arts Education to All Children: Lessons Learned from the First Half of the Ford Foundation's National Demonstration

Science.gov (United States)

Spilka, Gertrude; Long, Meg

2009-01-01

Interested in bringing the benefits of the arts as integral to quality education for all children, in 2004 the Ford Foundation launched the National Arts Education Initiative, a seven-year demonstration in nine communities across the United States. Building from arts education programs that serve "pockets" of children, Ford investments…

Geochemistry of Eagle Ford group source rocks and oils from the first shot field area, Texas

Science.gov (United States)

Edman, Janell D.; Pitman, Janet K.; Hammes, Ursula

2010-01-01

Total organic carbon, Rock-Eval pyrolysis, and vitrinite reflectance analyses performed on Eagle Ford Group core and cuttings samples from the First Shot field area, Texas demonstrate these samples have sufficient quantity, quality, and maturity of organic matter to have generated oil. Furthermore, gas chromatography and biomarker analyses performed on Eagle Ford Group oils and source rock extracts as well as weight percent sulfur analyses on the oils indicate the source rock facies for most of the oils are fairly similar. Specifically, these source rock facies vary in lithology from shales to marls, contain elevated levels of sulfur, and were deposited in a marine environment under anoxic conditions. It is these First Shot Eagle Ford source facies that have generated the oils in the First Shot Field. However, in contrast to the generally similar source rock facies and organic matter, maturity varies from early oil window to late oil window in the study area, and these maturity variations have a pronounced effect on both the source rock and oil characteristics. Finally, most of the oils appear to have been generated locally and have not experienced long distance migration. 

ANALISIS PENGARUH STRES KERJA DAN ORGANIZATIONAL CITIZENSHIP BEHAVIOUR TERHADAP KEPUASAN KERJA DAN DAMPAKNYA TERHADAP RETENSI KARYAWAN PADA FORD JAKARTA PUSAT

OpenAIRE

Stefhani; Laksmi Sito Dwi Irvianti

2014-01-01

Ford Jakarta Pusat is an authorized automotive dealer company. This study was conducted to determine how much influence of work stress and Organizational Citizenship Behaviour on job satisfaction and the impact on employee retention. There were 50 employees in Ford Jakarta Pusat used as research object. Data were obtained by spreading the questionnaire to the respondents using Cross Sectional Time Horizon. The data have been collected and processed using Path Analysis approach. According to t...

Influences of Eagle Ford Shale Development on Superintendent Leadership Experiences: A Phenomenological Narrative

Science.gov (United States)

Moczygemba, Jeanette Winn

2017-01-01

This phenomenological narrative study examined the effects of the Eagle Ford Shale development upon public school superintendent leadership experiences during the boom phase of the energy industry expansion. The four research questions investigated the shale development's influence on experiences in the areas of instruction, finance and…

Becoming through Revolutionary Pedagogy: An Interview with Curry Malott and Derek R. Ford

Science.gov (United States)

Wubbena, Zane C.

2016-01-01

In this interview, Curry Malott and Derek R. Ford discuss their new book, "Marx, Capital, and Education: Towards a Critical Pedagogy of Becoming." The interview begins with a general inquiry into their intellectual backgrounds as scholar-activists and, importantly, comrades. The authors then discuss the process of collaborating together…

A Semiotic Analysis of Visual Elements Particular to the Medium of Comics in Alan Ford by Max Bunker and Magnus

Directory of Open Access Journals (Sweden)

Hrvoje Gržina

2014-12-01

Full Text Available This paper presents the results of a semiotic analysis of visual elements characteristic for the medium of comic books applied to the first seventy-five issues of the Croatian edition of Alan Ford. After a description of the cultural and historical framework, it analyzes individual signs in comics and different elements specific for expression in comic books in Western culture with the aim of exploring which of these signs are present in Alan Ford, and to what extent. The results show that the analyzed comic book is deeply rooted in the visual and literary Western tradition, and that it contains virtually all the characteristic elements of representation in comic books. However, the paper also concludes that certain iconic elements of the vocabulary of comics – i.e. onomatopoeic neologisms – are to a certain extent specific and typical only for Alan Ford.

The Eagle Ford Shale, Texas: an initial insight into Late Cretaceous organic-rich mudrock palaeoenvironments

Science.gov (United States)

Forshaw, Joline; Jarvis, Ian; Trabucho-Alexandre, João; Tocher, Bruce; Pearce, Martin

2014-05-01

The hypothesised reduction of oxygen within the oceans during the Cretaceous is believed to have led to extended intervals of regional anoxia in bottom waters, resulting in increased preservation of organic matter and the deposition of black shales. Episodes of more widespread anoxia, and even euxinia, in both bottom and surface waters are associated with widespread black shale deposition during Ocean Anoxic Events (OAEs). The most extensive Late Cretaceous OAE, which occurred ~ 94 Ma during Cenomanian-Turonian boundary times, and was particularly well developed in the proto-North Atlantic and Tethyan regions, lasted for around 500 kyr (OAE2). Although the causes of this and other events are still hotly debated, research is taking place internationally to produce a global picture of the causes and consequences of Cretaceous OAEs. Understanding OAEs will enable a better interpretation of the climate fluctuations that ensued, and their association with the widespread deposition of black shales, rising temperatures, increased pCO2, enhanced weathering, and increased nutrient fluxes. The Eagle Ford Formation, of Cenomanian - Turonian age, is a major shale gas play in SW and NE Texas, extending over an area of more than 45,000 km2. The formation, which consists predominantly of black shales (organic-rich calcareous mudstones), was deposited during an extended period of relative tectonic quiescence in the northern Gulf Coast of the Mexico Basin, bordered by reefs along the continental shelf. The area offers an opportunity to study the effects of OAE2 in an organic-rich shelf setting. The high degree of organic matter preservation in the formation has produced excellent oil and gas source rocks. Vast areas of petroleum-rich shales are now being exploited in the Southern States of the US for shale gas, and the Eagle Ford Shale is fast becoming one of the countries largest producers of gas, oil and condensate. The Eagle Ford Shale stratigraphy is complex and heterogeneous

Geology and sequence stratigraphy of undiscovered oil and gas resources in conventional and continuous petroleum systems in the Upper Cretaceous Eagle Ford Group and related strata, U.S. Gulf Coast Region

Science.gov (United States)

Dubiel, Russell F.; Pearson, Ofori N.; Pitman, Janet K.; Pearson, Krystal M.; Kinney, Scott A.

2012-01-01

The U.S. Geological Survey (USGS) recently assessed the technically recoverable undiscovered oil and gas onshore and in State waters of the Gulf Coast region of the United States. The USGS defined three assessment units (AUs) with potential undiscovered conventional and continuous oil and gas resources in Upper Cretaceous (Cenomanian to Turonian) strata of the Eagle Ford Group and correlative rocks. The assessment is based on geologic elements of a total petroleum system, including hydrocarbon source rocks (source rock maturation, hydrocarbon generation and migration), reservoir rocks (sequence stratigraphy and petrophysical properties), and traps (formation, timing, and seals). Conventional oil and gas undiscovered resources are in updip sandstone reservoirs in the Upper Cretaceous Tuscaloosa and Woodbine Formations (or Groups) in Louisiana and Texas, respectively, whereas continuous oil and continuous gas undiscovered resources reside in the middip and downdip Upper Cretaceous Eagle Ford Shale in Texas and the Tuscaloosa marine shale in Louisiana. Conventional resources in the Tuscaloosa and Woodbine are included in the Eagle Ford Updip Sandstone Oil and Gas AU, in an area where the Eagle Ford Shale and Tuscaloosa marine shale display vitrinite reflectance (Ro) values less than 0.6%. The continuous Eagle Ford Shale Oil AU lies generally south of the conventional AU, is primarily updip of the Lower Cretaceous shelf edge, and is defined by thermal maturity values within shales of the Eagle Ford and Tuscaloosa that range from 0.6 to 1.2% Ro. Similarly, the Eagle Ford Shale Gas AU is defined downdip of the shelf edge where source rocks have Ro values greater than 1.2%. For undiscovered oil and gas resources, the USGS assessed means of: 1) 141 million barrels of oil (MMBO), 502 billion cubic feet of natural gas (BCFG), and 4 million barrels of natural gas liquids (MMBNGL) in the Eagle Ford Updip Sandstone Oil and Gas AU; 2) 853 MMBO, 1707 BCFG, and 34 MMBNGL in the

Assessment of undiscovered oil and gas resources in conventional and continuous petroleum systems in the Upper Cretaceous Eagle Ford Group, U.S. Gulf Coast region, 2011

Science.gov (United States)

Dubiel, Russell F.; Pitman, Janet K.; Pearson, Ofori N.; Pearson, Krystal; Kinney, Scott A.; Lewan, Michael D.; Burke, Lauri; Biewick, Laura; Charpentier, Ronald R.; Cook, Troy A.; Klett, Timothy R.; Pollastro, Richard M.; Schenk, Christopher J.

2012-01-01

Using a geology-based assessment methodology, the U.S. Geological Survey assessed means of (1) 141 million barrels of oil (MMBO), 502 billion cubic feet of natural gas (BCFG), and 16 million barrels of natural gas liquids (MMBNGL) in the conventional Eagle Ford Updip Sandstone Oil and Gas Assessment Unit (AU); (2) 853 MMBO, 1,707 BCFG, and 34 MMBNGL in the continuous Eagle Ford Shale Oil AU; and (3) 50,219 BCFG and 2,009 MMBNGL in the continuous Eagle Ford Shale Gas AU in onshore lands and State waters of the Gulf Coast.

Baseflow recession analysis across the Eagle Ford shale play (Texas, USA)

Science.gov (United States)

Arciniega, Saul; Brena-Naranjo, Agustin; Hernandez-Espriu, Jose Antonio; Pedrozo-Acuña, Adrian

2016-04-01

Baseflow is an important process of the hydrological cycle as it can be related to aquatic ecosystem health and groundwater recharge. The temporal and spatial dynamics of baseflow are typically governed by fluctuations in the water table of shallow aquifers hence groundwater pumping and return flow can greatly modify baseflow patterns. More recently, in some regions of the world the exploitation of gas trapped in shale formations by means of hydraulic fracturing (fracking) has raised major concerns on the quantitative and qualitative groundwater impacts. Although fracking implies massive amounts of groundwater withdrawals, its contribution on baseflow decline has not yet been fully investigated. Furthermore, its impact with respect to other human activities or climate extremes such as irrigation or extreme droughts, respectively, remain largely unknown. This work analyzes baseflow recession time-space patterns for a set of watersheds located across the largest shale producer in the world, the Eagle Ford shale play in Texas (USA). The period of study (1985-2014) includes a pre-development and post-development period. The dataset includes 56 hydrometric time series located inside and outside the shale play. Results show that during the development and expansion of the Eagle Ford play, around 70 % of the time series displayed a significant decline wheras no decline was observed during the pre-development)

76 FR 16472 - Petition for Exemption From the Vehicle Theft Prevention Standard; Ford Motor Company

Science.gov (United States)

2011-03-23

... From the Vehicle Theft Prevention Standard; Ford Motor Company AGENCY: National Highway Traffic Safety... vehicle line in accordance with Sec. 543.9(c)(2) of 49 CFR part 543, Exemption from the Theft Prevention... vehicle theft as compliance with [[Page 16473

77 FR 5302 - Ford Motor Company, Receipt of Petition for Decision of Inconsequential Noncompliance

Science.gov (United States)

2012-02-02

..., Light Vehicle Brake Systems. Ford has filed an appropriate report pursuant to 49 CFR Part 573, Defect... clarity. (b) Vehicles manufactured with a split service brake system may use a common brake warning... the telltales used for Brake Warning, Park Brake Warning and Antilock Braking System (ABS) failure...

Late Holocene Hydrologic Variability in the southeast Mojave Desert using sediments from Ford Lake, California

Science.gov (United States)

Leidelmeijer, J.; Kirby, M.; Anderson, W. T., Jr.; Mayer, S. A.; Palermo, J. A.; Stout, C.; Shellhorn, A.; Weisberg, G.; Rangel, H.; Hess, B.

2017-12-01

Most published lacustrine studies located in the Mojave Desert focus on lakes that receive the majority of their water from the Mojave River (e.g., Silver Lake, Cronese Lakes, Soda Lake, etc). Consequently, these Mojave River-fed lake sites record coastal hydroclimatic signals rather than a solely Mojave-only signal. The reason for this signal-disconnect is that the Mojave River is sourced in the San Bernardino Mountains, where annual precipitation is dictated by coastal hydroclimates. Therefore, much remains unknown about how the Mojave Desert changed during the Holocene at sub-millennial time scales. To address this problem and fill in an important geographical gap, we focus on Ford Lake in the southeastern Mojave Desert. Ford Lake is an internally drained, closed basin, and it is completely disconnected from the Mojave River. As a result, it represents one of the first lakes studied in the Mojave Desert with a climate signal that is 100% Mojave. Sediments from Ford Lake provide valuable context for understanding hydroclimatic variability exclusive to the Mojave Desert. To date, two hand-dug 1.5 m trenches (depocenter and littoral zone) and 3 overlapping sediments cores from the lake's depocenter have been sampled. The total core length is 3.55 m and bottomed in coarse alluvium, suggesting we captured the complete lacustrine sediment package. Initial results by Mayer (2016) focused on the most recent 1200 calendar years before present, or the upper 2.16 m. Mayer (2016) found evidence for increased run-off (wetter climate) during the Little Ice Age and reduced run-off (drier climate) during the Medieval Climatic Anomaly. Here, we complete the study, improving age control using sediment charcoal. Grain size, magnetic susceptibility, percent total organic matter, percent total carbonate content, C:N ratios and C and N isotopic analyses are (will be) measured at 1 cm contiguous intervals. The Ford Lake record has been (will be) compared to pre-existing regional

Grantee Spotlight: Marvella Ford, Ph.D. - Reducing Barriers to Surgical Cancer Care among African Am

Science.gov (United States)

Drs. Marvella E. Ford and Nestor F. Esnaola were awarded a five-year NIH/NIMHD R01 grant to evaluate a patient navigation intervention to reduce barriers to surgical cancer care and improving surgical resection rates in African Americans with lung cancer.

Marketingová strategie společnosti Ford na domácím a zahraničních trzích

OpenAIRE

Hamáčková, Lucie

2010-01-01

The main objective of this bachelor's thesis is the analysis of marketing strategy of the Ford Motor Company on the domestic market and on the foreign markets. The thesis summarizes all marketing instruments used for achievement of strategic and marketing objectives. Also is in the thesis Explorer how deep marketing strategies are influenced by globalization and how the current financial crisis change marketing policy of Ford Motor Company.

Regional ozone impacts of increased natural gas use in the Texas power sector and development in the Eagle Ford shale.

Science.gov (United States)

Pacsi, Adam P; Kimura, Yosuke; McGaughey, Gary; McDonald-Buller, Elena C; Allen, David T

2015-03-17

The combined emissions and air quality impacts of electricity generation in the Texas grid and natural gas production in the Eagle Ford shale were estimated at various natural gas price points for the power sector. The increased use of natural gas in the power sector, in place of coal-fired power generation, drove reductions in average daily maximum 8 h ozone concentration of 0.6-1.3 ppb in northeastern Texas for a high ozone episode used in air quality planning. The associated increase in Eagle Ford upstream oil and gas production nitrogen oxide (NOx) emissions caused an estimated local increase, in south Texas, of 0.3-0.7 ppb in the same ozone metric. In addition, the potential ozone impacts of Eagle Ford emissions on nearby urban areas were estimated. On the basis of evidence from this work and a previous study on the Barnett shale, the combined ozone impact of increased natural gas development and use in the power sector is likely to vary regionally and must be analyzed on a case by case basis.

Installation and evaluation of a nitrogen-16 detector in the Ford nuclear reactor

International Nuclear Information System (INIS)

Burn, R.R.

1995-01-01

Core differential temperature is the final measure of steady-state power at the Ford nuclear reactor. During some evolutions, such as changing the number of cooling-tower fans in operation, differential temperature undergoes a transient and does not provide an accurate measure of true power. A 16 N detector was installed to provide a more stable measure of power, even under transient conditions

78 FR 69931 - Ford Motor Company, Grant of Petition for Decision of Inconsequential Noncompliance

Science.gov (United States)

2013-11-21

... and Displays and the requirements of S5.5.5 of FMVSS No. 135, Light Vehicle Brake Systems. Ford has... clarity. (b) Vehicles manufactured with a split service brake system may use a common brake warning... braking system occur, even in the absence of the required BRAKE label on the indicator. The manufacturer...

Supporting Teaching and Learning Using Authentic Scientific Texts: A Rejoinder to Danielle J. Ford

Science.gov (United States)

Yarden, Anat; Falk, Hedda; Federico-Agraso, Marta; Jimenez-Aleixandre, Maria Pilar; Norris, Stephen P.; Phillips, Linda M.

2009-01-01

In her commentary Danielle J. Ford mainly focused on three issues that highlight the promises and challenges for the use of Adapted Primary Literature (APL) in science curricula: the possible contribution of APL to authentic experiences in secondary schools, implementation issues of APL including the support required for the teachers, and the…

76 FR 2444 - Petition for Exemption From the Vehicle Theft Prevention Standard; Ford Motor Company

Science.gov (United States)

2011-01-13

... From the Vehicle Theft Prevention Standard; Ford Motor Company AGENCY: National Highway Traffic Safety... vehicle line in accordance with 49 CFR Part 543, Exemption from the Theft Prevention Standard. This... standard equipment is likely to be as effective in reducing and deterring motor vehicle theft as compliance...

78 FR 5560 - Ford Motor Company, Receipt of Petition for Decision of Inconsequential Noncompliance

Science.gov (United States)

2013-01-25

... turned to the ``on'' (run) position when the engine is not running, or when the ignition (start) switch is in a position between ``on'' (run) and ``start'' that is designated by the manufacturer as a check... driven over 4 miles-per-hour. (7) Ford is unaware of any field or owner complaints or injuries regarding...

Service to the Electric Utility Industry by the Ford Nuclear Reactor, University of Michigan

International Nuclear Information System (INIS)

Burn, R.R.; Simpson, P.A.; Cook, G.M.

1993-01-01

Since 1977, the staff of the University of Michigan's Ford Nuclear Reactor has been providing irradiation, testing, analytical, and training services to electric utilities and to suppliers of the nuclear electric utility industry. This paper discusses the reactor's irradiation facilities; reactor programs and utilization; materials testing programs; neutron activation analysis activities; and training programs conducted

Changes of Proteases, Antiproteases, and Pathogens in Cystic Fibrosis Patients’ Upper and Lower Airways after IV-Antibiotic Therapy

Directory of Open Access Journals (Sweden)

Ulrike Müller

2015-01-01

Full Text Available Background. In cystic fibrosis (CF the upper (UAW and lower airways (LAW are reservoirs for pathogens like Pseudomonas aeruginosa. The consecutive hosts’ release of proteolytic enzymes contributes to inflammation and progressive pulmonary destruction. Objectives were to assess dynamics of protease : antiprotease ratios and pathogens in CF-UAW and LAW sampled by nasal lavage (NL and sputum before and after intravenous- (IV- antibiotic therapy. Methods. From 19 IV-antibiotic courses of 17 CF patients NL (10 mL/nostril and sputum were collected before and after treatment. Microbiological colonization and concentrations of NE/SLPI/CTSS (ELISA and MMP-9/TIMP-1 (multiplex bead array were determined. Additionally, changes of sinonasal symptoms were assessed (SNOT-20. Results. IV-antibiotic treatment had more pronounced effects on inflammatory markers in LAW, whereas trends to decrease were also found in UAW. Ratios of MMP-9/TIMP-1 were higher in sputum, and ratios of NE/SLPI were higher in NL. Remarkably, NE/SLPI ratio was 10-fold higher in NL compared to healthy controls. SNOT-20 scores decreased significantly during therapy (P=0.001. Conclusion. For the first time, changes in microbiological patterns in UAW and LAW after IV-antibiotic treatments were assessed, together with changes of protease/antiprotease imbalances. Delayed responses of proteases and antiproteases to IV-antibiotic therapy were found in UAW compared to LAW.

Changes in baseflow patterns in water-limited shale oil and gas regions: the Eagle Ford play

Science.gov (United States)

Arciniega, S.; Brena-Naranjo, J. A.; Hernández-Espriú, A.; Pedrozo-Acuña, A.

2016-12-01

Quantifying and analyzing the contribution of groundwater from shallow aquifers to rivers as baseflow is very important for water supply and riverine ecosystem health, especially in water-limited catchments. Baseflow depends on the water available (precipitation), vegetation (land use, water use), aquifer properties and water-table depth. In this context, human activities such as groundwater abstraction for multiple purposes can alter the relationship between aquifer storage and baseflow. In this study, we analyzed observed changes in baseflow patterns of 40 catchments located across the Eagle Ford shale gas/oil play (Texas) during the period 1986-2015. The Eagle Ford sedimentary formation is actually the largest shale oil producing region in the US with large production in shale gas. Intensive unconventional resources extraction in the Eagle Ford play started in 2009 and gas/oil production increased faster than in other plays, accompanied by a rise in groundwater consumption for HF purposes. Spatial and temporal impacts on baseflow at the Eagle Ford play derived from HF were assessed by means of different patterns such as baseflow hydrograph separation, flow-duration curves, empirical storage-discharge relationships and streamflow recession curve analysis. A comparison during different periods of water use for HF activities was performed: pre-development period (1986-2000); moderate period (2001-2008); and intensive period (2009-2015). The pre-development period was considered as a baseline and catchments located inside and outside the play area were separately analyzed. The results show negative changes on baseflow patterns during the intensive HF period that were not observed during the moderate period, especially in catchments located inside the play. These changes were also characterized by a decline on mean annual baseflow volume and shorter hydrograph recession times, that led to a shift in the streamflow regime in some catchments from perennial to

Evaluation of Military Fuels Using a Ford 6.7L Powerstroke Diesel Engine

Science.gov (United States)

2011-08-01

engine exhaust backpressure to the Ford recommended 11psi specification. 5  Emissions were directly sampled from an exhaust probe installed...between the engine and exhaust system backpressure valve. Emissions were measured using a Horiba MEXA- 1600D Motor Exhaust Gas Analyzer. Exhaust ... engine load increases the pilot fuel injection parameters are relatively more effective in rate-shaping the combustion event and the relative

Redes de producción global y aprendizaje local para la competitividad en el sector automotriz: los casos de Ford-Hermosillo y Toyota-Tijuana

Directory of Open Access Journals (Sweden)

Óscar Contreras

2016-03-01

Full Text Available Este trabajo tiene tres objetivos: a mostrar las características de la nueva organización de producción en Ford Hermosillo y Toyota Tijuana; b analizar las consecuencias de incorporar compañías locales en la cadena de proveedores, y c analizar los mecanismos de transferencia de conocimiento de manufactura y capacidades gerenciales de las firmas líderes hacia las empresas locales. Los datos utilizados para el análisis en el caso de Ford provienen de un estudio reciente coordinado por óscar Contreras, basado en una encuesta con proveedores de Ford-Hermosillo, y en entrevistas con gerentes de empresas proveedoras de primera y segunda línea. En el caso de Tijuana, el análisis se basa en entrevistas realizadas con Toyota en el periodo 2003-2005, y con proveedores en 2006.

78 FR 4192 - Petition for Exemption From the Vehicle Theft Prevention Standard; Ford Motor Company

Science.gov (United States)

2013-01-18

... From the Vehicle Theft Prevention Standard; Ford Motor Company AGENCY: National Highway Traffic Safety... vehicle line in accordance with Sec. 543.9(c)(2) of 49 CFR part 543, Exemption from the Theft Prevention... vehicle theft as compliance with the parts-marking requirements of the Theft Prevention Standard (49 CFR...

75 FR 30103 - Petition for Exemption From the Vehicle Theft Prevention Standard; Ford Motor Company

Science.gov (United States)

2010-05-28

... From the Vehicle Theft Prevention Standard; Ford Motor Company AGENCY: National Highway Traffic Safety... vehicle line in accordance with Sec. 543.9(c)(2) of 49 CFR Part 543, Exemption from the Theft Prevention... vehicle theft as compliance with the parts-marking requirements of the Theft Prevention Standard (49 CFR...

75 FR 65514 - Automotive Components Holdings, LLC, A Subsidiary of Ford Motor Company, Saline Plant Division...

Science.gov (United States)

2010-10-25

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,029] Automotive Components Holdings, LLC, A Subsidiary of Ford Motor Company, Saline Plant Division, Saline, MI; Notice of Affirmative Determination Regarding Application for Reconsideration By application sent to this office on April 8, 2010, the...

Effective biofilm removal and changes in bacterial biofilm building capacity after wound debridement with low-frequency ultrasound as part of wound bed preparation before skin grafting

Directory of Open Access Journals (Sweden)

Yarets Y

2017-03-01

Full Text Available Yuliya Yarets Clinical Laboratory Medicine Department, The Republican Scientific Centre for Radiation Medicine and Human Ecology, Gomel, Belarus Abstract: The aim of the study was to evaluate the efficacy of ultrasonic-assisted wound debridement (UAW used for wound bed preparation of chronic wounds prior to skin grafting. Initially, 140 patients were enrolled into study. Group 1 patients (n=53 with critically colonized wounds underwent a single UAW procedure before skin grafting. Group 2 patients (n=87 with colonized wounds received two UAW sessions, skin grafting followed by the second UAW treatment. Initial wound classification in colonized and critically colonized wounds did not correlate with results from microbiological analysis of wound swab samples. Hence, comparison of efficacy of one or two debridement sessions was conducted solely for a similar group of patients, that is, patients with colonized wounds of group 1 (n=40 and group 2 (n=47. In wounds of group 1 patients, a single debridement session resulted in reduction of bacteria from >104 to <104 CFU/mL. However, bacteria remaining at wound site showed minor differences in biofilm slime production, with skin graft failure being observed in 25% cases. In wounds of group 2 patients, two debridement sessions significantly reduced bacterial presence up to <102 CFU/mL. Bacteria remaining at wound site showed low capacity for biofilm slime production and high accumulation of biomass; a complete graft healing was observed in all patients. We suggest two to three debridement sessions with UAW to be most effective in wound bed preparation before skin grafting of chronic wounds. UAW showed to be effective in cleaning the wound bed, destroying the extracellular substances in biofilms, and influencing biofilm slime building capacity of bacteria left at wound site. Keywords: wound debridement, wound bed preparation, biofilm, low-frequency ultrasound, skin grafting, biofilm assay

Petrophysical characterization of the Eagle Ford Shale in south Texas

Energy Technology Data Exchange (ETDEWEB)

Mullen, J [Halliburton, Houston, TX (United States)

2010-07-01

The Eagle Ford shale play extends from the Mexican border in south Texas to the East Texas Basin. There are many challenges in developing the play into an economically viable venture. The shale production characteristics vary across the play, and the shale is producing dry gas in some areas and wet gas or oil in others. Some regions are naturally fractured, while others are not, and the play must be hydraulically fractured to be economically productive. It is therefore important to understand the local-area reservoir characteristics when trying to complete each well, particularly since successful completion techniques in one well may not necessarily work in another, even in the same field. This paper discussed the integration of different data-acquisition and reservoir-characterization techniques, such as mudlogs, basic openhole logs, and advanced logs, including dipole sonic; geochemical; magnetic resonance-imaging log; and core analysis. These techniques provide a better understanding of the reservoir and help to determine the shale's petrophysical characteristics and build a locally validated petrophysical model that can be applied to future wells with reduced data-acquisition programs to grade the reservoir. A model was developed to determine the surrounding lithology and clay typing in addition to the hydrocarbon resource potential of the well. The tool was also used to determine the location of organic-rich zones and to determine where to perforate based on geomechanical issues. The model provided information on the Eagle Ford shale play such as location of brittle zones; location of permeable zones; frac-design parameters; clay typing; organic content; volumetric assessment; porosity, permeability, and free fluid; and plasticity. 9 refs., 1 tab., 17 figs.

Methane and benzene in drinking-water wells overlying the Eagle Ford, Fayetteville, and Haynesville Shale hydrocarbon production areas

Data.gov (United States)

Department of the Interior — Groundwater samples were collected from domestic and public-supply wells in the Eagle Ford study area in 2015–16, in the Fayetteville study area in 2015, and in the...

Mobile equipment maintenance at Elk Valley Coal Corporation Fording River

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-01

Major loading and support equipment, haul trucks, and the number of staff and hourly tradesmen working in the maintenance manpower division at Elk Valley Coal are listed. Maintenance strategies are safety, high maintenance of equipment availabilities and reliability, cost reduction, and maximized productivity of assets. Maintenance assets comprise a large shop, shovel and drill crew, machine shop, light vehicle facility, line crew, radio technicians, and cranes. Most maintenance work is completed in- house. Fording River uses a Computerized Maintenance Management System (CMMS) that was developed in-house to match business needs. Several examples of the application of Reliability Centered Maintenance (RCM) are described. 12 figs., 2 tabs.

Mid-to-Late Holocene Hydrologic Variability in the Southeastern Mojave Desert Using Sediments from Ford Lake

Science.gov (United States)

Mayer, S. A.; Kirby, M. E.; Anderson, W. T., Jr.; Stout, C.; Palermo, J. A.

2015-12-01

The focal point of most lacustrine studies in the Mojave National Preserve (MNP) to date has been on lakes fed by the Mojave River. The source of the Mojave River is found on the northern flank of the San Bernardino Mountains. Consequently, the lakes that receive these waters are predominantly responding to the winter-only coastal southwest United States climate (e.g., Kirby et al., 2015 - Silver Lake); to a lesser degree, these lakes are also influenced by the Mojave's bimodal winter/summer climate. Ford Lake, located in the southeastern Mojave Desert is a small closed basin lake with its drainage basin located exclusively within the Mojave Desert. Therefore, sediment collected from Ford Lake contains a 100% Mojave-only climate signal. A 2.18 m sediment core was collected from the lake's depocenter in May 2015. Sediment analyses at 1 cm contiguous intervals include: magnetic susceptibility (MS), percent total organic matter, percent total carbonate content, and grain size analysis; C:N ratios, C and N isotope (δ13C and δ15N) analyses, and macrofossil counts are determined at 2 cm intervals. The site's age model is based on accelerator mass spectrometry (AMS) radiocarbon ages from discrete organic macrofossils or bulk organic carbon. To deconvolve the coastal climate, winter-only signal from the Mojave-only climate signal the data from Ford Lake will be compared to one Mojave River fed lake (Silver) and several southern California lakes (Lower Bear, Lake Elsinore, Dry Lake, and Zaca Lake). Our results will be analyzed in the context of climate forcings such as insolation and ocean - atmosphere dynamics.

Record of Decision for the Ford Building Waste Unit (643-11G) Operable Unit; FINAL

International Nuclear Information System (INIS)

Fraley, S.

2002-01-01

This decision document presents the selected remedial for the Ford Building Waste Unit (FBWU), in Aiken, South Carolina, which was chosen in accordance with CERCLA, as amended by SARA, and, to the extent practical, the National Oil and Hazardous Substances Pollution Contingency Plan (NCP). This decision is based on the Administrative Record File for this specific RCRA/CERCLA site

An Appreciation of Clinton B. Ford and the AAVSO of Fifty Years Ago

Science.gov (United States)

Hull, T.

2012-06-01

This is a rather personal story about Clinton B. Ford, my boyhood mentor in astronomy, and about the influence of the AAVSO and Clint on my life and career. While much has been written on Clint, this addresses the man, and his kindness. Naturally I joined the AAVSO (a little early, I was fifteen) and attended the AAVSO 50th Annual Meeting at Harvard College Observatory. Remembrance of Clint and the 50th Annual Meeting is given.

Poverty and Malnutrition in Latin America. Early Childhood Intervention Programs: A Report to the Ford Foundation.

Science.gov (United States)

Pollitt, Ernesto; And Others

This book presents a comprehensive review of empirical research on early childhood education and human development in Latin America. Commissioned in 1976 by the Office of Latin America and the Caribbean, part of the International Division of the Ford Foundation, New York, the study was two-faceted. First, researchers were instructed to review…

Source apportionment of hydrocarbons measured in the Eagle Ford shale

Science.gov (United States)

Roest, G. S.; Schade, G. W.

2016-12-01

The rapid development of unconventional oil and gas in the US has led to hydrocarbon emissions that are yet to be accurately quantified. Emissions from the Eagle Ford Shale in southern Texas, one of the most productive shale plays in the U.S., have received little attention due to a sparse air quality monitoring network, thereby limiting studies of air quality within the region. We use hourly atmospheric hydrocarbon and meteorological data from three locations in the Eagle Ford Shale to assess their sources. Data are available from the Texas commission of environmental quality (TCEQ) air quality monitors in Floresville, a small town southeast of San Antonio and just north of the shale area; and Karnes city, a midsize rural city in the center of the shale. Our own measurements were carried out at a private ranch in rural Dimmit County in southern Texas from April to November of 2015. Air quality monitor data from the TCEQ were selected for the same time period. Non-negative matrix factorization in R (package NMF) was used to determine likely sources and their contributions above background. While the TCEQ monitor data consisted mostly of hydrocarbons, our own data include both CO, CO2, O3, and NOx. We find that rural Dimmit County hydrocarbons are dominated by oil and gas development sources, while central shale hydrocarbons at the TCEQ monitoring sites have a mix of sources including car traffic. However, oil and gas sources also dominate hydrocarbons at Floresville and Karnes City. Toxic benzene is nearly exclusively due to oil and gas development sources, including flaring, which NMF identifies as a major hydrocarbon source in Karnes City. Other major sources include emissions of light weight alkanes (C2-C5) from raw natural gas emissions and a larger set of alkanes (C2-C10) from oil sources, including liquid storage tanks.

Status of the Ford program to evaluate ceramics for stator applications in automotive gas turbine engines

Science.gov (United States)

Trela, W.

1980-01-01

The paper reviews the progress of the major technical tasks of the DOE/NASA/Ford program Evaluation of Ceramics for Stator Applications in Automotive Gas Turbine Engines: reliability prediction, stator fabrication, material characterization, and stator evaluation. A fast fracture reliability model was prepared for a one-piece ceramic stator. Periodic inspection results are presented.

Inter-Organizational Trust in EDI Adoption: The Case of Ford Motor Company and PBR Limited in Australia.

Science.gov (United States)

Ratnasingam, Pauline

2001-01-01

This study examines behavioral dimensions of trading partner trust in EDI (electronic data interchange) adoption via a qualitative interpretative case study conducted between an automotive manufacturer (Ford Motor Company) in Australia and their first tier supplier, PBR Limited. Findings suggest that trust is important for cooperative long-term…

Ford motor company NDE facility shielding design

International Nuclear Information System (INIS)

Metzger, R. L.; Van Riper, K. A.; Jones, M. H.

2005-01-01

Ford Motor Company proposed the construction of a large non-destructive evaluation laboratory for radiography of automotive power train components. The authors were commissioned to design the shielding and to survey the completed facility for compliance with radiation doses for occupationally and non-occupationally exposed personnel. The two X-ray sources are Varian Linatron 3000 accelerators operating at 9-11 MV. One performs computed tomography of automotive transmissions, while the other does real-time radiography of operating engines and transmissions. The shield thickness for the primary barrier and all secondary barriers were determined by point-kernel techniques. Point-kernel techniques did not work well for skyshine calculations and locations where multiple sources (e.g. tube head leakage and various scatter fields) impacted doses. Shielding for these areas was determined using transport calculations. A number of MCNP [Briesmeister, J. F. MCNPCA general Monte Carlo N-particle transport code version 4B. Los Alamos National Laboratory Manual (1997)] calculations focused on skyshine estimates and the office areas. Measurements on the operational facility confirmed the shielding calculations. (authors)

Ford Motor Company NDE facility shielding design.

Science.gov (United States)

Metzger, Robert L; Van Riper, Kenneth A; Jones, Martin H

2005-01-01

Ford Motor Company proposed the construction of a large non-destructive evaluation laboratory for radiography of automotive power train components. The authors were commissioned to design the shielding and to survey the completed facility for compliance with radiation doses for occupationally and non-occupationally exposed personnel. The two X-ray sources are Varian Linatron 3000 accelerators operating at 9-11 MV. One performs computed tomography of automotive transmissions, while the other does real-time radiography of operating engines and transmissions. The shield thickness for the primary barrier and all secondary barriers were determined by point-kernel techniques. Point-kernel techniques did not work well for skyshine calculations and locations where multiple sources (e.g. tube head leakage and various scatter fields) impacted doses. Shielding for these areas was determined using transport calculations. A number of MCNP [Briesmeister, J. F. MCNPCA general Monte Carlo N-particle transport code version 4B. Los Alamos National Laboratory Manual (1997)] calculations focused on skyshine estimates and the office areas. Measurements on the operational facility confirmed the shielding calculations.

Cross-Border Labor Organizing in the Garment and Automobile Industries: The Phillips Van-Heusen and Ford Cuautitlan Cases

Directory of Open Access Journals (Sweden)

Ralph Armbruster

2015-08-01

Full Text Available The globalization of the world economy has created new opportunities for cross-border labor organizing. In this paper I examine two case studies of cross -border labor organizing. One case involves Phillips Van-Hernen (PVH workers in Guatemala City, and the other Ford automobile workers in Cuautitlan, Mexico. The PVH case illustrates the potential for cross-border labor organizing in the highly mobile garment industry. The PVH workers' union and their cross-border allies adopted a "strategic cross-border organizing model" that included consumer and trade pressure, an active international trade secretariat, and several other strategies, to achieve an amazing victory. However, the Ford Cuautitlan case demonstrates that corporatist state-labor relations and internal union conflicts have limited cross-border organizing in the automobile industry. These two case studies and their different outcomes have many important lessons for academics and activists interested in cross-border labor organizing.

Static and dynamic traversable wormhole geometries satisfying the Ford-Roman constraints

International Nuclear Information System (INIS)

Kuhfittig, Peter K.F.

2002-01-01

It was shown by Ford and Roman in 1996 that quantum field theory severely constrains wormhole geometries on a macroscopic scale. The first part of this paper discusses a wide class of wormhole solutions that meet these constraints. The type of shape function used is essentially generic. The constraints are then discussed in conjunction with various redshift functions. Violations of the weak energy condition and traversability criteria are also considered. The second part of the paper analyzes analogous time-dependent (dynamic) wormholes with the aid of differential forms. It is shown that a violation of the weak energy condition is not likely to be avoidable even temporarily

Ford/BASF/UM Activities in Support of the Hydrogen Storage Engineering Center of Excellence

Energy Technology Data Exchange (ETDEWEB)

Veenstra, Mike [Ford Motor Company, Dearborn, MI (United States); Purewal, Justin [Ford Motor Company, Dearborn, MI (United States); Xu, Chunchuan [Ford Motor Company, Dearborn, MI (United States); Yang, Jun [Ford Motor Company, Dearborn, MI (United States); Blaser, Rachel [Ford Motor Company, Dearborn, MI (United States); Sudik, Andrea [Ford Motor Company, Dearborn, MI (United States); Siegel, Don [Univ. of Michigan, Ann Arbor, MI (United States); Ming, Yang [Univ. of Michigan, Ann Arbor, MI (United States); Liu, Dong' an [Univ. of Michigan, Ann Arbor, MI (United States); Chi, Hang [Univ. of Michigan, Ann Arbor, MI (United States); Gaab, Manuela [BASF SE, Ludwigshafen (Germany); Arnold, Lena [BASF SE, Ludwigshafen (Germany); Muller, Ulrich [BASF SE, Ludwigshafen (Germany)

2015-06-30

Widespread adoption of hydrogen as a vehicular fuel depends critically on the development of low-cost, on-board hydrogen storage technologies capable of achieving high energy densities and fast kinetics for hydrogen uptake and release. As present-day technologies -- which rely on physical storage methods such as compressed hydrogen -- are incapable of attaining established Department of Energy (DOE) targets, development of materials-based approaches for storing hydrogen have garnered increasing attention. Material-based storage technologies have potential to store hydrogen beyond twice the density of liquid hydrogen. To hasten development of these ‘hydride’ materials, the DOE previously established three centers of excellence for materials storage R&D associated with the key classes of materials: metal hydrides, chemical hydrogen, and adsorbents. While these centers made progress in identifying new storage materials, the challenges associated with the engineering of the system around a candidate storage material are in need of further advancement. In 2009 the DOE established the Hydrogen Storage Engineering Center of Excellence with the objective of developing innovative engineering concepts for materials-based hydrogen storage systems. As a partner in the Hydrogen Storage Engineering Center of Excellence, the Ford-UM-BASF team conducted a multi-faceted research program that addresses key engineering challenges associated with the development of materials-based hydrogen storage systems. First, we developed a novel framework that allowed for a material-based hydrogen storage system to be modeled and operated within a virtual fuel cell vehicle. This effort resulted in the ability to assess dynamic operating parameters and interactions between the storage system and fuel cell power plant, including the evaluation of performance throughout various drive cycles. Second, we engaged in cost modeling of various incarnations of the storage systems. This analysis

Daily Management System of the Henry Ford Production System: QTIPS to Focus Continuous Improvements at the Level of the Work.

Science.gov (United States)

Zarbo, Richard J; Varney, Ruan C; Copeland, Jacqueline R; D'Angelo, Rita; Sharma, Gaurav

2015-07-01

To support our Lean culture of continuous improvement, we implemented a daily management system designed so critical metrics of operational success were the focus of local teams to drive improvements. We innovated a standardized visual daily management board composed of metric categories of Quality, Time, Inventory, Productivity, and Safety (QTIPS); frequency trending; root cause analysis; corrective/preventive actions; and resulting process improvements. In 1 year (June 2013 to July 2014), eight laboratory sections at Henry Ford Hospital employed 64 unique daily metrics. Most assessed long-term (>6 months), monitored process stability, while short-term metrics (1-6 months) were retired after successful targeted problem resolution. Daily monitoring resulted in 42 process improvements. Daily management is the key business accountability subsystem that enabled our culture of continuous improvement to function more efficiently at the managerial level in a visible manner by reviewing and acting based on data and root cause analysis. Copyright© by the American Society for Clinical Pathology.

Quantifying alkane emissions in the Eagle Ford Shale using boundary layer enhancement

Science.gov (United States)

Roest, Geoffrey; Schade, Gunnar

2017-09-01

The Eagle Ford Shale in southern Texas is home to a booming unconventional oil and gas industry, the climate and air quality impacts of which remain poorly quantified due to uncertain emission estimates. We used the atmospheric enhancement of alkanes from Texas Commission on Environmental Quality volatile organic compound monitors across the shale, in combination with back trajectory and dispersion modeling, to quantify C2-C4 alkane emissions for a region in southern Texas, including the core of the Eagle Ford, for a set of 68 days from July 2013 to December 2015. Emissions were partitioned into raw natural gas and liquid storage tank sources using gas and headspace composition data, respectively, and observed enhancement ratios. We also estimate methane emissions based on typical ethane-to-methane ratios in gaseous emissions. The median emission rate from raw natural gas sources in the shale, calculated as a percentage of the total produced natural gas in the upwind region, was 0.7 % with an interquartile range (IQR) of 0.5-1.3 %, below the US Environmental Protection Agency's (EPA) current estimates. However, storage tanks contributed 17 % of methane emissions, 55 % of ethane, 82 % percent of propane, 90 % of n-butane, and 83 % of isobutane emissions. The inclusion of liquid storage tank emissions results in a median emission rate of 1.0 % (IQR of 0.7-1.6 %) relative to produced natural gas, overlapping the current EPA estimate of roughly 1.6 %. We conclude that emissions from liquid storage tanks are likely a major source for the observed non-methane hydrocarbon enhancements in the Northern Hemisphere.

78 FR 59011 - Annual Notice of Interest Rates of Federal Student Loans Made Under the William D. Ford Federal...

Science.gov (United States)

2013-09-25

... DEPARTMENT OF EDUCATION Annual Notice of Interest Rates of Federal Student Loans Made Under the... Aid announces the interest rates for loans made under the William D. Ford Federal Direct Loan (Direct...(b)), provides formulas for determining the interest rates charged to borrowers for loans made under...

78 FR 53431 - Annual Notice of Interest Rates of Federal Student Loans Made Under the William D. Ford Federal...

Science.gov (United States)

2013-08-29

... Notice of Interest Rates of Federal Student Loans Made Under the William D. Ford Federal Direct Loan... Operating Officer for Federal Student Aid announces the interest rates for the period July 1, 2013, through...(b)), provides formulas for determining the interest rates charged to borrowers for loans made under...

William D. Ford Federal Direct Loan Program. Final Regulations. Federal Register, Department of Education, 34 CFR Part 685

Science.gov (United States)

National Archives and Records Administration, 2014

2014-01-01

The purpose of this regulatory action is to amend the regulations governing the William D. Ford Federal Direct Loan (Direct Loan) Program (§ 685.200 of title 34 of the Code of Federal Regulations (CFR)). These regulations strengthen and improve administration of the Federal Direct PLUS Loan Program authorized under title IV of the Higher Education…

Quantifying alkane emissions in the Eagle Ford Shale using boundary layer enhancement

Directory of Open Access Journals (Sweden)

G. Roest

2017-09-01

Full Text Available The Eagle Ford Shale in southern Texas is home to a booming unconventional oil and gas industry, the climate and air quality impacts of which remain poorly quantified due to uncertain emission estimates. We used the atmospheric enhancement of alkanes from Texas Commission on Environmental Quality volatile organic compound monitors across the shale, in combination with back trajectory and dispersion modeling, to quantify C2–C4 alkane emissions for a region in southern Texas, including the core of the Eagle Ford, for a set of 68 days from July 2013 to December 2015. Emissions were partitioned into raw natural gas and liquid storage tank sources using gas and headspace composition data, respectively, and observed enhancement ratios. We also estimate methane emissions based on typical ethane-to-methane ratios in gaseous emissions. The median emission rate from raw natural gas sources in the shale, calculated as a percentage of the total produced natural gas in the upwind region, was 0.7 % with an interquartile range (IQR of 0.5–1.3 %, below the US Environmental Protection Agency's (EPA current estimates. However, storage tanks contributed 17 % of methane emissions, 55 % of ethane, 82 % percent of propane, 90 % of n-butane, and 83 % of isobutane emissions. The inclusion of liquid storage tank emissions results in a median emission rate of 1.0 % (IQR of 0.7–1.6 % relative to produced natural gas, overlapping the current EPA estimate of roughly 1.6 %. We conclude that emissions from liquid storage tanks are likely a major source for the observed non-methane hydrocarbon enhancements in the Northern Hemisphere.

Ford Plug-In Project: Bringing PHEVs to Market Demonstration and Validation Project

Energy Technology Data Exchange (ETDEWEB)

D' Annunzio, Julie [Ford Motor Company, Dearborn, MI (United States); Slezak, Lee [U.S. DOE Office of Energy Efficiency & Renewable Energy, Washington, DC (United States); Conley, John Jason [National Energy Technology Lab. (NETL), Albany, OR (United States)

2014-03-26

This project is in support of our national goal to reduce our dependence on fossil fuels. By supporting efforts that contribute toward the successful mass production of plug-in hybrid electric vehicles, our nation’s transportation-related fuel consumption can be offset with energy from the grid. Over four and a half years ago, when this project was originally initiated, plug-in electric vehicles were not readily available in the mass marketplace. Through the creation of a 21 unit plug-in hybrid vehicle fleet, this program was designed to demonstrate the feasibility of the technology and to help build cross-industry familiarity with the technology and interface of this technology with the grid. Ford Escape PHEV Demonstration Fleet 3 March 26, 2014 Since then, however, plug-in vehicles have become increasingly more commonplace in the market. Ford, itself, now offers an all-electric vehicle and two plug-in hybrid vehicles in North America and has announced a third plug-in vehicle offering for Europe. Lessons learned from this project have helped in these production vehicle launches and are mentioned throughout this report. While the technology of plugging in a vehicle to charge a high voltage battery with energy from the grid is now in production, the ability for vehicle-to-grid or bi-directional energy flow was farther away than originally expected. Several technical, regulatory and potential safety issues prevented progressing the vehicle-to-grid energy flow (V2G) demonstration and, after a review with the DOE, V2G was removed from this demonstration project. Also proving challenging were communications between a plug-in vehicle and the grid or smart meter. While this project successfully demonstrated the vehicle to smart meter interface, cross-industry and regulatory work is still needed to define the vehicle-to-grid communication interface.

A labor perspective on workplace reproductive hazards: past history, current concerns, and positive directions.

OpenAIRE

Graham, T; Lessin, N; Mirer, F

1993-01-01

The Supreme Court's March 1991 ruling in United Automobile Workers (UAW) versus Johnson Controls barring corporate "fetal protection policies" was a major victory for women's employment rights and has health and safety implications for both sexes. However, 2 years after the Court's decision, the union's work is far from over. The UAW has yet to see what policy Johnson Controls will implement in place of the old one. Formulating solutions to the concerns of workers who are exposed daily to rep...

Origin Of Black Shale (Marl) Formation Aided By Continuous Volcanism For 10Ma Including Oceanic Anoxic Event, OAE2 (93-93.5 Ma) In The Eagle Ford Formation In South Texas

Science.gov (United States)

Chakrabarty, P.; Basu, A. R.

2017-12-01

We report LA-ICPMS U-Pb ages and Hf isotopes of zircons, petrography, major and trace elements and X-ray diffraction (XRD) analyses of whole rock black shales(marls) from volcanic subsurface as well as surface exposure ash beds of the Eagle Ford and Boquillas Formations in South Texas. Zircons from the middle part of the 300ft long Eagle Ford cores yield ages of 93.2±1.66 Ma, 94.13±1.25 Ma and 93.7±1.9 Ma. These ages are consistent with the Cenomanian-Turonian (C-T) age of deposition in three contiguous cores with spatial separation of 140 miles. An approximate 10Ma duration of deposition of volcanic ash and marl, at a rate of 28ft/Ma for the Eagle Ford is suggested from the 85.76 to 95.5 Ma ages. These ages are from the Eagle Ford ash beds, below the Austin Chalk and above the Buda Limestone and cover the Oceanic Anoxic Event 2 at the C-T boundary. Zircons from 7 ash beds in the surface exposures of the Boquillas Formation near Del Rio, yield ages between 84.63 Ma - 90.91 Ma, implying younger than C-T boundary ages for these samples. The mineralogy, major and trace elements of the ash beds suggest their source from nearby arc-derived calc-alkaline volcanism. The ɛHf(T) of the analyzed ash bed zircons yield values between 0 - +8 averaging at +3.5, clearly indicating a mantle component in the host magmas of the zircons. This initial range of ɛHf(T) is similar to arc-volcanism signatures such as the Quaternary andesitic volcanism in Central Mexico. Petrographic analyses of marls away from the visible tuff layer contain phenocrysts of biotite, alkali feldspar and andesitic rock fragments. The whole rock marl with high concentration of some transition metals (V, Zn, Ni, Pb, Mo) and relatively higher MgO and TiO2 contents indicate contemporaneous arc volcanic activity at the time of marl deposition. XRD of subsurface Eagle Ford bulk marl samples from different depths in 4 cores, show volcanogenic clays, such as montmorillonite, vermiculite, dickite and halloysite

The Uhlenbeck-Ford model: Exact virial coefficients and application as a reference system in fluid-phase free-energy calculations

Science.gov (United States)

Paula Leite, Rodolfo; Freitas, Rodrigo; Azevedo, Rodolfo; de Koning, Maurice

2016-11-01

The Uhlenbeck-Ford (UF) model was originally proposed for the theoretical study of imperfect gases, given that all its virial coefficients can be evaluated exactly, in principle. Here, in addition to computing the previously unknown coefficients B11 through B13, we assess its applicability as a reference system in fluid-phase free-energy calculations using molecular simulation techniques. Our results demonstrate that, although the UF model itself is too soft, appropriately scaled Uhlenbeck-Ford (sUF) models provide robust reference systems that allow accurate fluid-phase free-energy calculations without the need for an intermediate reference model. Indeed, in addition to the accuracy with which their free energies are known and their convenient scaling properties, the fluid is the only thermodynamically stable phase for a wide range of sUF models. This set of favorable properties may potentially put the sUF fluid-phase reference systems on par with the standard role that harmonic and Einstein solids play as reference systems for solid-phase free-energy calculations.

Geologic and engineering characterization of Geraldine Ford field, Reeves and Culberson Counties, Texas. Topical report -- 1997

Energy Technology Data Exchange (ETDEWEB)

Dutton, S.P.; Malik, M.A.; Asquith, G.B.; Barton, M.D.; Cole, A.G.; Gogas, J.; Clift, S.J.; Guzman, J.I.

1998-04-01

The objective of this Class III project is to demonstrate that detailed reservoir characterization of clastic reservoirs in basinal sandstones of the Delaware Mountain Group in the Delaware Basin of West Texas and New Mexico is a cost-effective way to recover more of the original oil in place by strategic infill-well placement and geologically based field development. The study focused on Geraldine Ford field, which produces from the upper Bell Canyon formation (Ramsey sandstone). Petrophysical characterization of the Ford Geraldine unit was accomplished by integrating core and log data and quantifying petrophysical properties from wireline logs. The petrophysical data were used to map porosity, permeability, net pay, water saturation, mobile oil saturation, and other reservoir properties. Once the reservoir-characterization study was completed, a demonstration area of approximately 1 mi{sup 2} in the northern part of the unit was chosen for reservoir modeling/simulation. A quarter of a five-spot injection pattern in the demonstration area was selected for flow simulations, and two cases of permeability distribution were considered, one using stochastic permeability distribution generated by conditional simulation and the other using layered permeabilities. Flow simulations were performed using UTCOMP, an isothermal, three-dimensional, compositional simulator for miscible gas flooding. Results indicate that 10--30% (1 to 3 MMbbl) of remaining oil in place in the demonstration area can be produced by CO{sub 2} injection.

Identifying At-Risk Individuals for Insomnia Using the Ford Insomnia Response to Stress Test.

Science.gov (United States)

Kalmbach, David A; Pillai, Vivek; Arnedt, J Todd; Drake, Christopher L

2016-02-01

A primary focus of the National Institute of Mental Health's current strategic plan is "predicting" who is at risk for disease. As such, the current investigation examined the utility of premorbid sleep reactivity in identifying a specific and manageable population at elevated risk for future insomnia. A community-based sample of adults (n = 2,892; 59.3% female; 47.9 ± 13.3 y old) with no lifetime history of insomnia or depression completed web-based surveys across three annual assessments. Participants reported parental history of insomnia, demographic characteristics, sleep reactivity on the Ford Insomnia in Response to Stress Test (FIRST), and insomnia symptoms. DSM-IV diagnostic criteria were used to determine insomnia classification. Baseline FIRST scores were used to predict incident insomnia at 1-y follow-up. Two clinically meaningful FIRST cutoff values were identified: FIRST ≥ 16 (sensitivity 77%; specificity 50%; odds ratio [OR] = 2.88, P insomnia onset, even after controlling for stress exposure and demographic characteristics. Of the incident cases, insomniacs with highly reactive sleep systems reported longer sleep onset latencies (FIRST ≥ 16: 65 min; FIRST ≥ 18: 68 min) than participants with nonreactive insomnia (FIRST insomnia based on trait sleep reactivity. The FIRST accurately identifies a focused target population in which the psychobiological processes complicit in insomnia onset and progression can be better investigated, thus improving future preventive efforts. © 2016 Associated Professional Sleep Societies, LLC.

Integrated ground-based hyperspectral imaging and geochemical study of the Eagle Ford Group in West Texas

Science.gov (United States)

Sun, Lei; Khan, Shuhab; Godet, Alexis

2018-01-01

This study used ground-based hyperspectral imaging to map an outcrop of the Eagle Ford Group in west Texas. The Eagle Ford Group consists of alternating layers of mudstone - wackestone, grainstone - packstone facies and volcanic ash deposits with high total organic content deposited during the Cenomanian - Turonian time period. It is one of the few unconventional source rock and reservoirs that have surface representations. Ground-based hyperspectral imaging scanned an outcrop and hand samples at close ranges with very fine spatial resolution (centimeter to sub-millimeter). Spectral absorption modeling of clay minerals and calcite with the modified Gaussian model (MGM) allowed quantification of variations of mineral abundances. Petrographic analysis confirmed mineral identifications and shed light on sedimentary textures, and major element geochemistry supported the mineral quantification. Mineral quantification resulted in mapping of mudstone - wackestone, grainstone - packstone facies and bentonites (volcanic ash beds). The lack of spatial associations between the grainstones and bentonites on the outcrop calls into question the hypothesis that the primary productivity is controlled by iron availability from volcanic ash beds. Enrichment of molybdenum (Mo) and uranium (U) indicated "unrestricted marine" paleo-hydrogeology and anoxic to euxinic paleo-redox bottom water conditions. Hyperspectral remote sensing data also helped in creating a virtual outcrop model with detailed mineralogical compositions, and provided reservoir analog to extract compositional and geo-mechanical characteristics and variations. The utilization of these new techniques in geo-statistical analysis provides a workflow for employing remote sensing in resource exploration and exploitation.

Analisis Pengaruh Stres Kerja dan Organizational Citizenship Behavior terhadap Kepuasan Kerja dan Dampaknya terhadap Retensi Karyawan di Ford Jakarta Pusat

Directory of Open Access Journals (Sweden)

Stefhani Stefhani

2014-05-01

Full Text Available Ford Jakarta Pusat is an authorized automotive dealer company. This study was conducted to determine how much influence of work stress and Organizational Citizenship Behaviour on job satisfaction and the impact on employee retention. There were 50 employees in Ford Jakarta Pusat used as research object. Data were obtained by spreading the questionnaire to the respondents using Cross Sectional Time Horizon. The data have been collected and processed using Path Analysis approach. According to the research result, it shows that work stress and Organizational Citizenship Behaviour have a simultaneous and significant effect on job satisfaction although work stress individually does not have a significant effect on job satisfaction. Then, work stress, Organizational Citizenship Behaviour, and job satisfaction have a simultaneous and significant effect on employee retention although work stress individually does not have a significant effect on employee retention. After trimming process, the result shows that Organizational Citizenship Behaviour and job satisfaction have a simultaneous and significant effect on employee retention. It means that if the company wants to maintain and improve employee retention, it must improve the Organizational Citizenship Behaviour through Job Satisfaction.

COMPARTILHANDO CONHECIMENTO EM PROJETO AUTOMOTIVO: O ECOSPORT DA FORD DO BRASIL

Directory of Open Access Journals (Sweden)

Renelson Ribeiro Sampaio

2014-06-01

Full Text Available The experience lived by a project development team for the new EcoSport at Ford Motor in Camaçari, Bahia was investigated regarding the knowledge sharing between its members. The goal was to evaluate that process, aimed at improving the team’s work on new projects. The research focus was placed on two questions: a what modes of knowledge sharing were preferably practiced. b What was the effectiveness of these modes on the development process? To answer these questions, we conducted a survey among team’s members followed by an analysis of their social network. The research found isolated members or with few ties between them. The network was also isolated in relation to other important actors of the company. The modes of socialization for capturing knowledge and externalization for the transmission of knowledge were the most preferred and effective by the majority of the team members. The authors concluded that it is highly recommended to increase the balance of the knowledge sharing via the stimulation of modes of combination and internalization.

Assessing Stress-Induced Sleep Reactivity in College Students: The European Portuguese Version of the Ford Insomnia Response to Stress Test (FIRST)

OpenAIRE

Marques, Daniel Ruivo; Allen Gomes, Ana; Drake, Christopher Lawrence; Roth, Thomas; de Azevedo, Maria Helena Pinto

2016-01-01

Over the past few years, the comprehensive models of insomnia have exhibited impressive developments. However, there is scarce knowledge on predisposing or vulnerability factors for insomnia. One of the most promising constructs to aid in filling this gap is stress-induced sleep reactivity assessed through self-report. Our aim was to study the psychometric properties of the European Portuguese version of the Ford Insomnia Response to Stress Test (FIRST).

Statistical Process Control Techniques for the Telecommunications Systems Manager

Science.gov (United States)

1992-03-01

when Ford compared its transmissions with those made by Mazda for the same automobile. Ford found that the rework, scrap, warranty nad production costs...for Ford transmissions were significantly higher than Mazda’s. Internal investigations of the transmissions revealed that while all transmissions were...within specification limits, the Mazda transmissions 60 demonstrated no variability whatsoever from target values. The Mazda transmissions were built

Measurements of the HEU and LEU in-core spectra at the Ford Nuclear Reactor

Energy Technology Data Exchange (ETDEWEB)

Wehe, D K [Oak Ridge National Laboratory, Oak Ridge, TN (United States); King, J S; Lee, J C; Martin, W R [Department of Nuclear Engineering, University of Michigan, Ann Arbor, MI (United States)

1985-07-01

The Ford Nuclear Reactor (FNR) at the University of Michigan has been serving as the test site for a low-enriched uranium (LEU) fuel whole-core demonstration. As part of the experimental program, the differential neutron spectrum has been measured in a high-enriched uranium (HEU) core and an LEU core. The HEU and LEU spectra were determined by unfolding the measured activities of foils that were irradiated in the reactor. When the HEU and LEU spectra are compared from meV to 10 MeV, significant differences between the two spectra are apparent below 10 eV. These are probably caused by the additional {sup 238}U resonance absorption in the LEU fuel. No measurable difference occurs in the shape of the spectra above MeV. (author)

Uhlenbeck-Ford model: Phase diagram and corresponding-states analysis

Science.gov (United States)

Paula Leite, Rodolfo; Santos-Flórez, Pedro Antonio; de Koning, Maurice

2017-09-01

Using molecular dynamics simulations and nonequilibrium thermodynamic-integration techniques we compute the Helmholtz free energies of the body-centered-cubic (bcc), face-centered-cubic (fcc), hexagonal close-packed, and fluid phases of the Uhlenbeck-Ford model (UFM) and use the results to construct its phase diagram. The pair interaction associated with the UFM is characterized by an ultrasoft, purely repulsive pair potential that diverges logarithmically at the origin. We find that the bcc and fcc are the only thermodynamically stable crystalline phases in the phase diagram. Furthermore, we report the existence of two reentrant transition sequences as a function of the number density, one featuring a fluid-bcc-fluid succession and another displaying a bcc-fcc-bcc sequence near the triple point. We find strong resemblances to the phase behavior of other soft, purely repulsive systems such as the Gaussian-core model (GCM), inverse-power-law, and Yukawa potentials. In particular, we find that the fcc-bcc-fluid triple point and the phase boundaries in its vicinity are in good agreement with the prediction supplied by a recently proposed corresponding-states principle [J. Chem. Phys. 134, 241101 (2011), 10.1063/1.3605659; Europhys. Lett. 100, 66004 (2012), 10.1209/0295-5075/100/66004]. The particularly strong resemblance between the behavior of the UFM and GCM models are also discussed.

The Ford Nuclear Reactor demonstration project for the evaluation and analysis of low enrichment fuel

International Nuclear Information System (INIS)

Kerr, W.; King, J.S.; Lee, J.C.; Martin, W.R.; Wehe, D.K.

1991-07-01

The whole-core LEU fuel demonstration project at the University of Michigan was begun in 1979 as part of the Reduced Enrichment Research and Test Reactor (RERTR) Program at Argonne National Laboratory. An LEU fuel design was selected which would produce minimum perturbations in the neutronic, operations, and safety characteristics of the 2-MW Ford Nuclear Reactor (FNR). Initial criticality with a full LEU core on December 8, 1981, was followed by low- and full-power testing of the fresh LEU core, transitional operation with mixed HEU-LEU configurations, and establishment of full LEU equilibrium core operation. The transition from the HEU to the LEU configurations was achieved with negligible impact on experimental utilization and safe operation of the reactor. 78 refs., 74 figs., 84 tabs

[The PreFord Study. A prospective cohort study to evaluate the risk of a cardiovascular event (overall-collective) as well as a prospective, randomized, controlled, multicentre clinical intervention study (high-risk-collective) on primary prevention of cardiovascular diseases in the Ford Motor Company employees in Germany].

Science.gov (United States)

Gysan, D B; Latsch, J; Bjarnason-Wehrens, B; Albus, C; Falkowski, G; Herold, G; Mey, E; Heinzler, R; Montiel, G; Schneider, C A; Stützer, H; Türk, S; Weisbrod, M; Predel, H G

2004-02-01

The PreFord Study is a multicenter prospective cohort study to evaluate guideline based risk management on primary prevention of cardiovascular diseases. Furthermore a randomised controlled trial (RCT) will be designed to analyse the effect of a special intervention program. 40,000 employees of the Ford Motor Company, Visteon Company and Deutz Company in Germany will be included, monitored for ten years and the following primary endpoints will be investigated: 1. evaluation and comparison of established and newly developed risk-scores, 2. the relative impact of single and combined cardiovascular risk factors on cardiovascular diseases, 3. the influence of a novel occupationally integrated ambulant rehabilitation program in combination with a guideline oriented optimal drug therapy within a high risk group on the primary endpoint: risk reduction by, 4. the influence of this intervention on secondary endpoints: death, myocardial infarction and stroke, combined appearance of angina pectoris and hospitalisation, occurrence of cerebral circulatory disorder and hospitalisation, occurrence of peripheral occlusive arterial disease and hospitalisation and single cardiovascular risk factors and cost-benefit-analysis. Beginning with an cross sectional study there will be a systemic screening of cardiovascular risk profiles, of anthropometric data and different lifestyle-factors. Based on these data participants will be differentiated into three risk-groups according to the risk score of the European Society of Cardiology (risk of a lethal primary acute cardiovascular event: I 1- or = 5%). In the following longitudinal study different strategies will be applied: Group I: low risk ( 1.5% per year or >15% within the next 10 years) will be randomised into two interventional groups. The first one, the intervention-group "PreFord" will perform an occupational integrated rehabilitation program (2,5-3 hours twice a week, for 15 weeks according to the BAR guidelines) with a following

The RERTR demonstration experiments program at the Ford Nuclear Reactor

Energy Technology Data Exchange (ETDEWEB)

Wehe, D K; King, J S [Department of Nuclear Engineering, University of Michigan (United States)

1983-08-01

The purpose of this paper is to highlight a major part of the experimental work which is being carried out at the Ford Nuclear Reactor (FNR) in conjunction with the RERTR program. A demonstration experiments program has been developed to: 1) characterize the FNR in sufficient detail to discern and quantify neutronic differences between the high and low enriched cores; 2) provide the theoretical group with measurements to benchmark their calculations. As with any experimental program associated with a reactor, stringent constraints limit the experiments which can be performed. Some experiments are performed routinely on the FNR (such as control rod calibrations), and much data is already available. Unfortunately, the accuracy we demand precludes using much of this earlier data. And in many cases, the requirement of precise (and copious) data has led to either developing new techniques (as in the case of rhodium mapping and neutron diffraction) or to further refinements on existing methods (as in the case of spectral unfolding). Nevertheless, we have tried to stay within the realm of recognized, well-established experimental methods in order to assuage any doubts about measured differences between HEU and LEU core parameters. This paper describes the principal results of the experiments performed so far.

Los Hispanos: Problemas y Oportunidades. Resumen de la Actual Situacion Demografica, Economica, Social y Politica de los Hispanos en los Estados Unidos y de las Iniciativas Tomadas por la Fundacion Ford Para Hacer Frente a las Necesidades de esta Poblacion en Aumento y Determinar sus Efectos Sobre la Sociedad Estadounidense. Documento de Trabajo de la Fundacion Ford, No. 436.

Science.gov (United States)

Ford Foundation, New York, NY.

The Hispanic population's growing impact on American society has caused the Ford Foundation to explore new Foundation initiatives. The 1980 census revealed 14.6 million Hispanics: 60% Mexican American; 14% Puerto Rican; 6% Cuban, and 20% Other. The Hispanic population in the United States is growing and is characterized by diversity; rapid growth…

Operational impacts of low-enrichment uranium fuel conversion on the Ford Nuclear Reactor

International Nuclear Information System (INIS)

Bernal, F.E.; Brannon, C.C.; Burgard, N.E.; Burn, R.R.; Cook, G.M.; Simpson, P.A.

1985-01-01

The University of Michigan Department of Nuclear Engineering and the Michigan Memorial-Phoenix Project have been engaged in a cooperative effort with Argonne National Laboratory to test and analyze low-enrichment fuel in the Ford Nuclear Reactor (FNR). The effort was begun in 1979, as part of the Reduced Enrichment Research and Test Reactor Program, to demonstrate on a whole-core basis the feasibility of enrichment reduction from 93% to <20% in Materials Test Reactor-type fuel designs. The first low-enrichment uranium (LEU) core was loaded into the FNR and criticality was achieved on December 8, 1981. The final LEU core was established October 11, 1984. No significant operational impacts have resulted from conversion of the FNR to LEU fuel. Thermal flux in the core has decreased slightly; thermal leakage flux has increased. Rod worths, temperature coefficient, and void coefficient have changed imperceptibly. Impressions from the operators are that power defect has increased slightly and that fuel lifetime has increased

Propuesta de un plan estratégico de mercadeo para la marca de vehículos Ford en Costa Rica

OpenAIRE

Rodríguez Arguedas, Ronald; Solís Arce, Rita

2003-01-01

Universidad de Costa Rica. Posgrado en Administración y Dirección de Empresas. Maestría Profesional en Administración y Dirección de Empresas con énfasis en Mercadeo y Ventas Se propone un plan estratégico de mercadeo para la empresa Nacional Automotriz (NASA), distribuidor exclusivo de las líneas de vehículos Ford en Costa Rica, mediante una evaluación de las actuales estrategias aplicadas por la empresa y del mercado nacional automotriz, que permita a NASA aumentar su competitividad, inc...

Insect and avian fauna presence on the Ford assembly plant ecoroof

Energy Technology Data Exchange (ETDEWEB)

Coffman, R.R. [Ohio State Univ., Columbus, OH (United States). Dept. of Horticulture; Davis, G. [Ohio State Univ., Columbus, OH (United States). Dept. of Entomology

2005-07-01

This paper presented the results of a single season descriptive study of the insect and avian fauna present on a green roof installed at the Ford Motor Company's River Rouge assembly plant in Dearborn, Michigan. The study was part of a larger project investigating the similarities and differences between green roofs and terrestrial urban landscapes. Sweep netting was used to collect the insects, which were then placed in killing jars, separated, identified and stored. Invertebrates were identified and confirmed by entomology and arachnology taxonomic specialists. Bird observation times coincided with the insect sweeps, and data were recorded a total of 4 times during a period of 4 weeks. The study identified 29 insect species, 7 spider species, and 2 bird species. Winged insect families included flies, beetles, wasps, grasshoppers, plant bugs and leaf hoppers. Several types of spider and several species of birds were also observed. Findings supported the general assumption that ecoroofs create habitat. It was concluded that more studies are needed to better comprehend the behavior of invertebrate species and birds, as well as the population dynamics and community structure of the ecosystem. Future ecoroof community ecology studies may include varied collection methods and seasonal distribution of collection times. 10 refs., 4 tabs., 5 figs.

Correction to white-johnson, ford, and sellers (2010).

Science.gov (United States)

2015-01-01

Reports an error in "Parental racial socialization profiles: Association with demographic factors, racial discrimination, childhood socialization, and racial identity" by Rhonda L. White-Johnson, Kahlil R. Ford and Robert M. Sellers (Cultural Diversity and Ethnic Minority Psychology, 2010[Apr], Vol 16[2], 237-247). In the article, there was an error in the Measures subsection. The following citation should have been included in the third paragraph " Mothers' childhood racial socialization experiences. Prior racial socialization messages were assessed using four items adapted from the Comprehensive Race Socialization Inventory (Lesane- Brown, Brown, Caldwell, & Sellers, 2005)." Additionally, the included reference should have been included in the Reference section. (The following abstract of the original article appeared in record 2010-07475-016.) The authors examined patterns of racial socialization practices in a sample of 212 African American mothers. They investigated the relation between parent profiles of racial socialization messages with child and parent demographic factors and race-related experiences, as well as parent racial identity attitudes. Using latent class analyses, the authors identified 3 patterns of parent-reported racial socialization experiences: multifaceted, low race salience, and unengaged. In general, findings indicate that mothers in the multifaceted profile were more educated, experienced more racial discrimination, and talked about race during their childhood more than mothers in the unengaged profile. The multifaceted profile also differed from the low race salience and unengaged profiles on several racial identity dimensions. Although the patterned approach used in this study lends itself to a more complex study of racial socialization in future research, it also highlights the associations between parent's race-relevant experiences and the messages they communicate to their children about race. (PsycINFO Database Record (c) 2015 APA

Estratégias e Geração de Vantagem Competitiva no Mercado de Veículos Off Road: Análise Fenomenológica do Lançamento do Modelo Ford Ecosport no Brasil

Directory of Open Access Journals (Sweden)

Roberto Bazanini

2011-05-01

Full Text Available No universo da administração existem poucas pesquisas que fazem uso do método fenomenológico. O objetivo central da pesquisa está em identificar as inovações e o empreendedorismo decorrentes das principais estratégias empregadas pela Ford do Brasil, no projeto e lançamento do veículo EcoSport, em 2003, tendo como referencial teórico os pressupostos da teoria da RBV (Resource Based View complementada pelas vertentes estratégicas propostas pela Escola empreendedora, Escola do posicionamento e Escola ambiental. Por meio do emprego do método fenomenológico na pesquisa qualitativa, análise pós-factum, instrumentalizada através de entrevistas com especialista do mercado Off-Road, executivos da Ford, vendedores de concessionárias de automóveis próprias e concorrentes, buscou-se identificar os recursos geradores de vantagens competitivas. Os resultados da pesquisa apontam para a pertinência da análise fenomenológica ao detectar os recursos empregados pela Ford na perspectiva das estratégias de negócios: a presença do líder empreendedor; posicionamento do produto e capacidade produtiva em consonância com as exigências do ambiente. DOI: 10.5585/remark.v10i1.2203

RECYCLED TEXTILES USED IN AUTOMOTIVE INTERIORS. CASE STUDY- FORD MOTOR COMPANY

Directory of Open Access Journals (Sweden)

CUC Sunhilde

2017-05-01

Full Text Available The environmental movement is affecting all industries, but the textile and automotive industries are two of the few that are constantly being criticized. The automotive industry is the subject of much research, it is the largest manufacturing activity, there is a complex supply chain, is resource intensive and emits various hazardous gases and waste products. The article reviews the current state of automotive industry regarding the textile application. Automotive textiles have been classified as belonging to a category called “Mobiltech” which is one of the main streams of technical textiles. The term means all type of textile components e.g. fibers, filaments, yarns and the fabric used in automobiles. They are classed as technical textile because of the very high performance specifications and special properties required, different from those used in clothing and other applications. The performance of the automotive textiles depends on the fibre properties, fabric structures and various finishes used in the manufacturing processes. After a short presentation of used fibres in car interiors, with advantages and disadvantages it is presented the sustainable textile solutions for the automotive industry. The paper focuses in particular of the use of recycling of textile waste to highlight how the processes of recycled textiles and sustainable textiles production are linked in the automotive sector. A case study with Ford Motor Company outlines and examines their design, development and manufacture process for automotive textiles for car seat coverings and interiors

76 FR 30974 - Amended Revised Determination on Reconsideration

Science.gov (United States)

2011-05-27

... Training Center, Technology Training Joint Programs Staff, Including On-Site Leased Workers from Manpower... locations of UAW-Chrysler National Training Center, Technology Training Joint Programs Staff. The Department..., Technology Training Joint Programs Staff, including on-site leased workers from Manpower, Detroit, Michigan...

Hyperspectral-Augmented Target Tracking

Science.gov (United States)

2008-03-01

Make Model 1 White Volvo 740 GL 2 Black Mitsubishi Montero 3 White Honda Accord 4 Black Jeep Grand Cherokee 5 Maroon Toyota Camry 6 Dark Blue...Landrover Discovery 7 Blue Chevy Colorado 8 Gold Honda Odyssey 9 Silver Nissan Altima 10 Gold Honda Accord 11 Red VW Beetle Continued on next page 3-11 Table...Gold Saturn SL2 16 Gold Nissan Maxima 17 Red Saturn SL2 18 Black Pontiac Grand Am 19 Silver Ford Focus 20 Gray with Black top Chrysler Sebring

Why Sustainers Should Care About the Targeting Process

Science.gov (United States)

2016-02-29

1200 T: Recon GOLD / 13B SP TBD AWT/ AVN T: SPT Convoy GOLD / 13B SP 1315 / 1415 T: SPT Convoy Turani SP 1115 T: SPT Convoy GOLD / 13B SP 1315 / 1415 T...on the lookout for a white Ford observed). Legend A/DACG = Arrival/departure airfield control group AWT/ AVN = Air weapons teams/aviation BSA

Mechanical-Stratigraphic Characterization of the Eagle Ford Formation in Outcrop and Core, McMullen and Terrell Counties, Texas

Science.gov (United States)

Xu, G.; Chester, J. S.; Chester, F. M.

2017-12-01

The objective of this project is to characterize the geomechanical properties of individual and composite lithologic units over length scales of decimeter to tens of meters. We have characterized the stratigraphy and lithology of the Eagle Ford Formation in outcrops at Lozier and Antonio Canyons of West TX, and in core taken at 3.2 km depth in McMullen County, TX. Dominant lithologies examined include reworked ash layers, argillaceous mudstone, organic-rich mudstone, foraminifera wackestone, packstone, pyritic packstone, and foraminifera/dolomitic packstone-grainstone. Samples of these units are deformed in triaxial compression at 1- 40 MPa confining pressure (Pc), and room temperature and humidity. The elastic properties, pre-fracture yielding (ductility), and fracture strength are primarily a function of particle size, texture (degree of mud versus grain support), and composition. Young's Modulus (YM) and Poison's Ratio (PR) increase similarly with an increase in grain-support and carbonate content, and a decrease in organic matter and clay. The greatest change occurs at the transition from mud-supported to grain-supported textures where YM and PR increase by a factor of 3 and 1.5, respectively. Both YM and PR can display anisotropy with directional variation of 30%, most notably in micro-laminated units, but also in the more massive pyritic packstones. Overall, pre-fracture ductility decreases with an increase in carbonate content; ductile strain in the argillaceous- and organic-rich-mudstones is 1.4%, 3-4 times greater than that in the packstone/grainstone. Fracture strength increases with an increase in carbonate content and a decrease in clay content. The organic rich mudstone fails at 130 MPa, is nearly 2 times stronger than argillaceous mudstones, and 50% weaker than packstone/grainstones at 1 MPa Pc. The angle of internal friction is 45 degrees for all lithologies, consistent with a transition in fracture from opening- to shear-mode between 1 to 15 MPa Pc

The Impacts of Hydraulic Fracturing in the Eagle Ford Shale Region, South Texas: Hands-On Activities for Middle and High School Students

Science.gov (United States)

Kohlmeyer, C.; Loisel, J.; Schade, G. W.

2016-12-01

The Eagle Ford Shale (EFS) region of south-central Texas is strongly affected by a rapid increase in unconventional oil and gas production, and it ranks amongst the top production regions of the country. Across the EFS region and elsewhere, the fracking boom has been causing large emissions of methane (CH4) and non-methane hydrocarbons to the atmosphere, with direct consequences on atmospheric GHG concentration and air quality. An increase in seismic activity has also been reported in the area. Since these effects were initially underestimated, fracking operations remain largely unmitigated by regulation. As a result, large-scale oil and gas operations are found in close geographical proximity to rural communities who are uninformed and/or not accustomed to such operations and their effects on the environment and human health. Here we present a few hands-on activities that are being developed to educate middle and high school students on hydraulic fracturing and associated land-use change, water and air pollution, and seismicity induced by deep well injection. Modules on the carbon cycle (with an emphasis on CO2 and CH4), global environmental change, and human energy consumption around the world and main energy sources are also under development. Each activity is either based on scientific data gathered by students or information that is freely available; mapping exercises and time series analysis are included. For example, students will implement a geographic information system (GIS) to study local land-use change using satellite imagery analysis. These activities will be implemented in Fall 2016 and Spring 2017 in at least one Independent School District of the Eagle Ford Shale area. A broadly applicable educational booklet/teaching module on atmospheric CH4 emissions, with an emphasis on the environmental impacts of the oil and gas industry as the dominant source of emissions and land use change in shale areas, will be published.

Human Resource Development and New Technology in the Automobile Industry: A Case Study of Ford Motor Company's Dearborn Engine Plant. The Development and Utilization of Human Resources in the Context of Technological Change and Industrial Restructuring.

Science.gov (United States)

Chen, Kan; And Others

This report centers around a plant-level study of the development and utilization of human resources in the context of technological change and industrial restructuring in the crankshaft production area of Ford Motor Company's Dearborn Engine Plant (DEP). The introductory chapter describes how the study was conducted, provides an introduction to…

76 FR 10403 - General Motors Company, Pontiac Assembly; Pontiac, MI; Notice of Negative Determination on...

Science.gov (United States)

2011-02-24

... Agricultural Implement Workers of America (UAW) stated that production of standard cab and extended cab GMC... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,554] General Motors Company... October 25, 2010 (75 FR 65513). Workers at GM-Pontiac are engaged in employment related to the production...

StranshamFord v Minister of Justice and Correctional Services and Others: Can active voluntary euthanasia and doctorassisted suicide be legally justified and are they consistent with the biomedical ethical principles Some suggested guidelines for doct

Directory of Open Access Journals (Sweden)

David McQuoid-Mason

2015-11-01

Full Text Available The recent case of Stransham-Ford v Minister of Justice and Correctional Services and Others held that voluntary active euthanasia and doctor assisted suicide may be legally justified in certain circumstances. The court observed that the distinction between ‘active’ and ‘passive’ voluntary euthanasia is not legally tenable as in both instances the doctors concerned have the ‘actual’ or ‘eventual’ intention to terminate the patient’s life and have caused or hastened the patient’s death. It is argued that as the South African Constitution is the supreme law of the country, the fundamental rights of patients guaranteed in the Constitution cannot be undermined by ethical duties imposed on health care practitioners by international and national professional bodies. The court in the Stransham-Ford case did not use ethical theories and principles to decide the matter. It simply applied the values in the Constitution and the provisions of the Bill of Rights. However, in order to assist medical practitioners with practical guidelines with which many of them are familiar - rather than complicated unfamiliar philosophical arguments - the biomedical ethical principles of patient autonomy, beneficence, non-maleficence and justice or fairness are applied to active voluntary euthanasia and doctor-assisted suicide in the context of the Stransham-Ford case. Although the case has not set a precedent or opened the floodgates to doctor-assisted voluntary active euthanasia and it is open to Parliament, the Constitutional Court or other courts to develop the concept or outlaw it, some guidelines are offered for doctors to consider should they be authorized by a court to assist with voluntary active euthanasia.

La industria automotriz y el fomento a las cadenas productivas en Sonora: el caso de la Ford en Hermosillo

Directory of Open Access Journals (Sweden)

Fabiola Galicia-Bretón Mora

2011-01-01

Full Text Available La formación de cadenas productivas es una condición indispensable para el desarrollo económico local en el nuevo escenario que genera un entorno globalmente competitivo. En el caso de Sonora, a partir de la instalación de la planta de estampado y ensamble de la Ford Motor Company en Hermosillo en 1986, las empresas locales no han podido integrarse plenamente a los procesos productivos de la planta. Este fracaso tiene su principal origen en la inadecuada política industrial aplicada por los organismos gubernamentales y privados, junto con la falta de una cultura emprendedora que asuma mayores riesgos. En este artículo se presenta la historia de la industria automotriz en México, en especial el caso de Sonora. Los resultados permiten prever que difícilmente -en el corto plazo- se generarán encadenamientos productivos.

The Language of Colours. A Semiotic Analysis of Colours and Symbolic Imagery in Francis Ford Coppola’s "Bram Stoker’s Dracula" (1992

Directory of Open Access Journals (Sweden)

Veronika Bernard

2011-10-01

Full Text Available Reviews referring to Francis Ford Coppola’s Columbia Pictures Bram Stoker’s Dracula classic of 1992 recurrently mention the images owing to the camera work of Michael Ballhaus as the striking feature of the movie and highly praise them for their thematically coherent effect.. The colours, if mentioned at all, leave reviewers undecided to sceptical when it comes to evaluating their contribution to the overall composition of the film, though. By providing a semiotic analysis of colours and symbolic imagery the below article will show how colours and imagery in their inter-relatedness create coherence and cohesion with Coppola’s interpretation of Stoker’s Dracula as a religiously inspired morality play set in the context of Victorian cultural values and self-perception.

Deviation Management: Key Management Subsystem Driver of Knowledge-Based Continuous Improvement in the Henry Ford Production System.

Science.gov (United States)

Zarbo, Richard J; Copeland, Jacqueline R; Varney, Ruan C

2017-10-01

To develop a business subsystem fulfilling International Organization for Standardization 15189 nonconformance management regulatory standard, facilitating employee engagement in problem identification and resolution to effect quality improvement and risk mitigation. From 2012 to 2016, the integrated laboratories of the Henry Ford Health System used a quality technical team to develop and improve a management subsystem designed to identify, track, trend, and summarize nonconformances based on frequency, risk, and root cause for elimination at the level of the work. Programmatic improvements and training resulted in markedly increased documentation culminating in 71,641 deviations in 2016 classified by a taxonomy of 281 defect types into preanalytic (74.8%), analytic (23.6%), and postanalytic (1.6%) testing phases. The top 10 deviations accounted for 55,843 (78%) of the total. Deviation management is a key subsystem of managers' standard work whereby knowledge of nonconformities assists in directing corrective actions and continuous improvements that promote consistent execution and higher levels of performance. © American Society for Clinical Pathology, 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

Air sampler performance at Ford's farm range

International Nuclear Information System (INIS)

Glissmeyer, J.A.; Johnston, J.W.

1984-07-01

An air-sampling system for a large-caliber depleted uranium (DU) penetrator firing range was tested. The objectives of the test were: to determine the bias between the monitoring readings and DU concentrations; and to determine if the target bay real-time monitor (RTM) tracks the decaying dust concentration. The test procedure was to operate total and respirable airborne particle samplers adjacent to the target bay monitors. A series of air samples was also taken after the test firings adjacent to the target bay RTM. Exhaust particle samples were analyzed for gross alpha, gross beta and uranium content. The target bay RTM correlated well (0.977) with the sequential samples. Average concentration from the RTM did not correlate with either the long-term total or respirable sampler DU concentrations. The monitor used to confirm a low dust concentration when the door is open correlated well (0.810) with the RTM; the other bay monitor did not. In the ventilation discharge, the long-term average monitor readings did not correlate with DU concentrations, probably due to levels near lower detection limits. Smearable surface-contamination samples showed highest contamination on the equipment, gravel floor and exhaust intake. The location air-intake contamination increased over the first 3 rounds. Contamination was reduced by a low-pressure water spray washdown to about the same concentration as often the second round, then remained at about twice the level. 2 references, 18 figures, 16 tables. (MF)

Contribution of developing advanced engineering methods in interdisciplinary studying the piston rings from 1.6 spark ignited Ford engine at Technical University of Cluj-Napoca

Science.gov (United States)

-Aurel Cherecheş, Ioan; -Ioana Borzan, Adela; -Laurean Băldean, Doru

2017-10-01

Study of construction and wearing process in the case of piston-rings and other significant components from internal combustion engines leads at any time to creative and useful optimizing ideas, both in designing and manufacturing phases. Main objective of the present paper is to realize an interdisciplinary research using advanced methods in piston-rings evaluation of a common vehicle on the streets which is Ford Focus FYDD. Specific objectives are a theoretical study of the idea for advanced analysis method in piston-rings evaluation and an applied research developed in at Technical University from Cluj-Napoca with the motor vehicle caught in the repairing process.

Methane and Benzene in Drinking-Water Wells Overlying the Eagle Ford, Fayetteville, and Haynesville Shale Hydrocarbon Production Areas.

Science.gov (United States)

McMahon, Peter B; Barlow, Jeannie R B; Engle, Mark A; Belitz, Kenneth; Ging, Patricia B; Hunt, Andrew G; Jurgens, Bryant C; Kharaka, Yousif K; Tollett, Roland W; Kresse, Timothy M

2017-06-20

Water wells (n = 116) overlying the Eagle Ford, Fayetteville, and Haynesville Shale hydrocarbon production areas were sampled for chemical, isotopic, and groundwater-age tracers to investigate the occurrence and sources of selected hydrocarbons in groundwater. Methane isotopes and hydrocarbon gas compositions indicate most of the methane in the wells was biogenic and produced by the CO 2 reduction pathway, not from thermogenic shale gas. Two samples contained methane from the fermentation pathway that could be associated with hydrocarbon degradation based on their co-occurrence with hydrocarbons such as ethylbenzene and butane. Benzene was detected at low concentrations (2500 years, indicating the benzene was from subsurface sources such as natural hydrocarbon migration or leaking hydrocarbon wells. One sample contained benzene that could be from a surface release associated with hydrocarbon production activities based on its age (10 ± 2.4 years) and proximity to hydrocarbon wells. Groundwater travel times inferred from the age-data indicate decades or longer may be needed to fully assess the effects of potential subsurface and surface releases of hydrocarbons on the wells.

Spontaneous imbibition of water and determination of effective contact angles in the Eagle Ford Shale Formation using neutron imaging

Energy Technology Data Exchange (ETDEWEB)

DiStefano, Victoria H.; Cheshire, Michael C.; McFarlane, Joanna; Kolbus, Lindsay M.; Hale, Richard E.; Perfect, Edmund; Bilheux, Hassina Z.; Santodonato, Louis J.; Hussey, Daniel S.; Jacobson, David L.; LaManna, Jacob M.; Bingham, Philip R.; Starchenko, Vitaliy; Anovitz, Lawrence M.

2017-10-01

Understanding of fundamental processes and prediction of optimal parameters during the horizontal drilling and hydraulic fracturing process results in economically effective improvement of oil and natural gas extraction. Although, the modern analytical and computational models can capture fracture growth, there is a lack of experimental data on spontaneous imbibition and wettability in oil and gas reservoirs for the validation of further model development. In this work, we used neutron imaging to measure the spontaneous imbibition of water into fractures of Eagle Ford Shale with known geometries and fracture orientations. An analytical solution for a set of nonlinear second-order differential equations was applied to the measured imbibition data to determine effective contact angles. The analytical solution fit the measured imbibition data reasonably well and determined effective contact angles were slightly higher than static contact angles due to effects of in-situ changes in velocity, surface roughness, and heterogeneity of mineral surfaces on the fracture surface. Additionally, small fracture widths may have retarded imbibition and affected model fits, which suggests that average fracture widths are not satisfactory for modeling imbibition in natural systems.

Screening of extraction methods for glycoproteins from jellyfish ( Rhopilema esculentum) oral-arms by high performance liquid chromatography

Science.gov (United States)

Ren, Guoyan; Li, Bafang; Zhao, Xue; Zhuang, Yongliang; Yan, Mingyan; Hou, Hu; Zhang, Xiukun; Chen, Li

2009-03-01

In order to select an optimum extraction method for the target glycoprotein (TGP) from jellyfish ( Rhopilema esculentum) oral-arms, a high performance liquid chromatography (HPLC)-assay for the determination of the TGP was developed. Purified target glycoprotein was taken as a standard glycoprotein. The results showed that the calibration curves for peak area plotted against concentration for TGP were linear ( r = 0.9984, y = 4.5895 x+47.601) over concentrations ranging from 50 to 400 mgL-1. The mean extraction recovery was 97.84% (CV2.60%). The fractions containing TGP were isolated from jellyfish ( R. esculentum) oral-arms by four extraction methods: 1) water extraction (WE), 2) phosphate buffer solution (PBS) extraction (PE), 3) ultrasound-assisted water extraction (UA-WE), 4) ultrasound-assisted PBS extraction (UA-PE). The lyophilized extract was dissolved in Milli-Q water and analyzed directly on a short TSK-GEL G4000PWXL (7.8 mm×300 mm) column. Our results indicated that the UA-PE method was the optimum extraction method selected by HPLC.

Enrichment Of Volcanogenic Trace Elements, Co, Cr, Cu, Ni, Mo And Zr In A Continuous Subsurface Eagle Ford Core In South Texas And Origin Of The Oceanic Anoxic Event II At The Cenomanian-Turonian (C/T) Boundary

Science.gov (United States)

Valencia, D.; Basu, A. R.; Loocke, M. P.

2017-12-01

The Eagle Ford Formation containing the Cenomanian-Turonian (C/T) boundary continues to be studied globally not only for its economic potential and analog for `frack-able' unconventional organic-rich formations, but it is of particular interest to researchers because it was deposited across the C/T boundary recording an Oceanic Anoxic Event (OAE2). OAEs are short lived episodes (matter into the sedimentary record remains enigmatic. Geochemical and geochronological analysis of a subsurface 300ft long continuous core of the Eagle Ford Formation of South Texas shows evidence for volcanism throughout. This is confirmed by multiple thin intermittent bentonite beds. The whole rock black shale (marl) shows elevated concentrations of volcanogenic trace elements (Co, Cr, Cu, Ni, Mo and Zn) throughout the core. By sampling bentonite bed zircons near the inferred C/T boundary, U-Pb age of 93.2 ±1.7 Ma for the Eagle Ford is established. Using this horizon, the onset of OAE2 is constrained and well-correlated with the positive δ13C excursion. For the trace element analysis, the core was sampled at 10ft intervals for ICP-MS. The analytical results show significantly increased volcanogenic trace metal input correlating with increased Total Organic Carbon and positive δ13C values at the C/T dated zircon horizon. OAE2, defined by the positive δ13C excursion, was found to span over an interval of 85ft. With a definitive constraint for OAE2 established, this well-defined interval was analyzed at a much higher resolution using ED-XRF. The core was then sampled at 6' intervals throughout the C/T boundary at OAE2. The high-resolution sampling of the core shows 80-99% increase in abundance of Co, Cr, Cu, Ni, Mo, Zn over the average Post Australian Archean Shale(PAAS), representative of average continental crust. These volcanogenic-rich intervals reach peak values before the onset of OAE2 and at the maximum values for the positive δ13C isotope excursion directly after the 93.2 ±1

Propulsion and Power Rapid Response Research and Development (R&D) Support. Delivery Order 0011: Advanced Propulsion Fuels R&D, Subtask: Evaluation of 50/50 Hydroprocessed Renewable Jet Fuel and JP8 in the Ford 6.7L High-Pressure Common Rail Design Engine

Science.gov (United States)

2012-12-01

47 42. AF7938 50/50 JP-8/HRJ, Rear Pump Body Camshaft Bushing ........................................... 48 iii Approved for public...release; distribution unlimited. LIST OF FIGURES (Cont’d) Figure Page 43. AF7938 50/50 JP-8/HRJ, Front Pump Body Camshaft Bushing ...atmosphere. A butterfly valve was used to regulate engine exhaust backpressure to the Ford recommended 11psi specification. • Emissions were

PENERAPAN METODE ALGORITMA BELLMAN – FORD DALAM APLIKASI PENCARIAN LOKASI PERSEROAN TERBATAS DI PT. JAKARTA INDUSTRIAL ESTATE PULOGADUNG (PT. JIEP

Directory of Open Access Journals (Sweden)

Fenny Anggraini

2015-01-01

Full Text Available Kemacetan yang terjadi selama perjalanan sering mengganggu kegiatan sehari-hari. Setiap manusia ingin sampai ke tujuan dengan tepat waktu. Tetapi sering kali kemacetan menyebabkan keinginan manusia terhambat. Oleh karena itu, dibutuhkan suatu cara untuk menanggulangi masalah tersebut yaitu dengan mengetahui jarak tempuh minimum untuk mencapai suatu tempat. Persoalan lintasan terpendek yaitu menemukan lintasan terpendek antara dua atau beberapa simpul lebih yang berhubungan. Tujuannya memberikan informasi pencarian perusahaan di Kawasan Industri Pulogadung untuk memudahkan para pencari posisi perseroan terbatas menemukan letak perseroan terbatas yang dituju. Algoritma Bellman – Ford menghitung jarak terpendek (dari satu sumber pada sebuah graph berbobot, dimana dari satu sumber menghitung semua jarak terpendek yang berawal dari satu titik node. OpenStreetMap adalah sebuah proyek berbasis web untuk membuat peta seluruh dunia yang gratis dan terbuka, dibangun sepenuhnya oleh sukarelawan dengan melakukan survey menggunakan GPS, mendigitasi citra satelit, dan mengumpulan serta membebaskan data geografis yang tersedia di publik. Open Source Routing Machine atau OSRM adalah C ++ pelaksanaan mesin routing kinerja tinggi untuk jalur terpendek di jaringan jalan. Output berupa jarak terpendek dari titik awal pengguna berada sampai ke titik tujuan pengguna.

A labor perspective on workplace reproductive hazards: past history, current concerns, and positive directions.

Science.gov (United States)

Graham, T; Lessin, N; Mirer, F

1993-07-01

The Supreme Court's March 1991 ruling in United Automobile Workers (UAW) versus Johnson Controls barring corporate "fetal protection policies" was a major victory for women's employment rights and has health and safety implications for both sexes. However, 2 years after the Court's decision, the union's work is far from over. The UAW has yet to see what policy Johnson Controls will implement in place of the old one. Formulating solutions to the concerns of workers who are exposed daily to reproductive health hazards on the job will continue to be on labor's agenda. Preventing hazardous exposures is the first priority. This goal would be furthered by setting occupational health and safety standards designed to protect workers' general and reproductive health. Support for the Comprehensive Occupational Safety and Health Reform Act (COSHRA) would also positively affect health and safety in the workplace. Where hazards have not yet been abated, the framework of transfers and income protections for all workers with temporary job restrictions should be examined. The Legal/Labor Working Group convened at the Occupational and Environmental Reproductive Hazards Working Conference authored guidelines for developing a model reproductive hazards policy. These recommendations can serve as a guide for implementation of nondiscriminatory and health-protective policies by employers.

A SUSTENTABILIDADE EM FUNÇÃO DO USO NÃO SUSTENTÁVEL DOS RECURSOS NATURAIS NO OESTE BAIANO E EAGLE FORD TEXANO

Directory of Open Access Journals (Sweden)

Christian Brannstrom

2015-01-01

Full Text Available El artículo compara dos regiones con base en los discursos publicados em publicaciones bien diseminadas, complementada con investigación de campo. La región Oeste de Bahia, con agricultura intensive, compárase con el Eagle Ford Shale, región de producción no convencional de petroleo e gas natural. El trabajo focalízase en como las elites usan la sustentabilidad en la gobernanza ambiental para justificar el uso de los recursos naturales en la agricultura e los hidrocarbonos. Enfatizo como el espetáculo sirve para augmenter el “prestigio regional” (CHASE, 2003 e como los aspectos sociales de la sustentabilidad ajudan a consolidar las ambiciones de explotación de los recursos naturales. En los dos casos las elites regionals no reproducem verbatim los discursos nacionales, pero sí las elites investen en traduzir los discursos en formato regional o canalizar las preocupaciones regionales e los parametros regionales en nuevas soluciones discursivos para mantener la explotación de los recursos naturales.

The Impact Of The Definition Of Target Market On The Design Process In New Product Development: The Case Of New Ford Cargo

OpenAIRE

Tokatlı, Akgün

2004-01-01

The economic success of manufacturing companies depends on their ability to identify the needs of the customers and to develop new products to meet those needs rapidly. Achieving this goal is not solely a marketing problem, nor it is solely a design or a manufacturing problem; it is in fact a product development problem involving all of these functions. The subject of this study is to analyse the concept of target market in the product development process and its interaction with product desi...

Aerial radiological survey of the William B. McGuire Nuclear Station and surrounding area, Cowans Ford Dam, North Carolina, April 13-24, 1981

International Nuclear Information System (INIS)

Hobaugh, J.L.

1981-08-01

An aerial radiological survey was performed from 13 to 24 April 1981 over a 235 square kilometer area centered on the William B. McGuire Nuclear Station at Cowans Ford Dam, North Carolina. All gamma-photon data were collected by flying North-South lines spaced 228 meters apart at an altitude of 122 meters above ground level. Processed data showed that all gamma-photons detected within the survey area were those expected from naturally occurring terrestrial background emitters. Count rates obtained from the aerial platform were converted to exposure rates at 1 meter above the ground and are presented in the form of an isoradiation contour map. The observed exposure rates were between 5 and 22 microroentgens per hour (μR/h), with most of the area ranging from 5 to 9 μR/h. These values include an estimated cosmic ray contribution of 4.0 μR/h. The exposure rate obtained from soil samples taken from within the survey site displayed positive agreement with the aerial data

Time Series Analysis of Energy Production and Associated Landscape Fragmentation in the Eagle Ford Shale Play

Science.gov (United States)

Pierre, Jon Paul; Young, Michael H.; Wolaver, Brad D.; Andrews, John R.; Breton, Caroline L.

2017-11-01

Spatio-temporal trends in infrastructure footprints, energy production, and landscape alteration were assessed for the Eagle Ford Shale of Texas. The period of analysis was over four 2-year periods (2006-2014). Analyses used high-resolution imagery, as well as pipeline data to map EF infrastructure. Landscape conditions from 2006 were used as baseline. Results indicate that infrastructure footprints varied from 94.5 km2 in 2008 to 225.0 km2 in 2014. By 2014, decreased land-use intensities (ratio of land alteration to energy production) were noted play-wide. Core-area alteration by period was highest (3331.6 km2) in 2008 at the onset of play development, and increased from 582.3 to 3913.9 km2 by 2014, though substantial revegetation of localized core areas was observed throughout the study (i.e., alteration improved in some areas and worsened in others). Land-use intensity in the eastern portion of the play was consistently lower than that in the western portion, while core alteration remained relatively constant east to west. Land alteration from pipeline construction was 65 km2 for all time periods, except in 2010 when alteration was recorded at 47 km2. Percent of total alteration from well-pad construction increased from 27.3% in 2008 to 71.5% in 2014. The average number of wells per pad across all 27 counties increased from 1.15 to 1.7. This study presents a framework for mapping landscape alteration from oil and gas infrastructure development. However, the framework could be applied to other energy development programs, such as wind or solar fields, or any other regional infrastructure development program.

The U.S. Automobile Industry: Will It Survive Increasing International Competition

Science.gov (United States)

1991-04-22

the small car sales prize with its Escort. In model year 1991 Ford introduced a new Escort. The new Escort borrows heavily 54 from Mazda to include the...by Chrysler, Ford and General Motors to transition from the post World War II period through the 1973 oil crisis to the present, and examine the...Auto Industry In 1903 Henry Ford founded the Ford Motor Company. Ford was born on a farm in Dearborn Michigan to Irish immigrant parents. The Ford

Fra Ford Ka til Ford Galaxy

DEFF Research Database (Denmark)

Rødgaard, Tove Schmidt

2007-01-01

Uddannelsespolitisk har det seneste år været det mest mærkelige, jeg har oplevet i mine mange år i denne sektor: i det tidlige forår 2006 begyndte de første rygter om en stor uddannelsesreform at dukke op – en reform der skulle omfatte hele det store felt af uddannelser indenfor det mellemlange, ...

76 FR 78043 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-Toyota Motor...

Science.gov (United States)

2011-12-15

... Production Act of 1993--Toyota Motor Corporation and Ford Motor Company Collaboration Notice is hereby given... Ford Motor Company Collaboration (``Toyota and Ford'') has filed written notifications simultaneously... venture are: Toyota Motor Corporation, Toyota City, JAPAN; and Ford Motor Company, Dearborn, MI. The...

Exercise Capacity and the Obesity Paradox in Heart Failure: The FIT (Henry Ford Exercise Testing) Project.

Science.gov (United States)

McAuley, Paul A; Keteyian, Steven J; Brawner, Clinton A; Dardari, Zeina A; Al Rifai, Mahmoud; Ehrman, Jonathan K; Al-Mallah, Mouaz H; Whelton, Seamus P; Blaha, Michael J

2018-05-03

To assess the influence of exercise capacity and body mass index (BMI) on 10-year mortality in patients with heart failure (HF) and to synthesize these results with those of previous studies. This large biracial sample included 774 men and women (mean age, 60±13 years; 372 [48%] black) with a baseline diagnosis of HF from the Henry Ford Exercise Testing (FIT) Project. All patients completed a symptom-limited maximal treadmill stress test from January 1, 1991, through May 31, 2009. Patients were grouped by World Health Organization BMI categories for Kaplan-Meier survival analyses and stratified by exercise capacity (<4 and ≥4 metabolic equivalents [METs] of task). Associations of BMI and exercise capacity with all-cause mortality were assessed using multivariable-adjusted Cox proportional hazards models. During a mean follow-up of 10.1±4.6 years, 380 patients (49%) died. Kaplan-Meier survival plots revealed a significant positive association between BMI category and survival for exercise capacity less than 4 METs (log-rank, P=.05), but not greater than or equal to 4 METs (P=.76). In the multivariable-adjusted models, exercise capacity (per 1 MET) was inversely associated, but BMI was not associated, with all-cause mortality (hazard ratio, 0.89; 95% CI, 0.85-0.94; P<.001 and hazard ratio, 0.99; 95% CI, 0.97-1.01; P=.16, respectively). Maximal exercise capacity modified the relationship between BMI and long-term survival in patients with HF, upholding the presence of an exercise capacity-obesity paradox dichotomy as observed over the short-term in previous studies. Copyright © 2018 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Predicting diabetes mellitus using SMOTE and ensemble machine learning approach: The Henry Ford ExercIse Testing (FIT) project.

Science.gov (United States)

Alghamdi, Manal; Al-Mallah, Mouaz; Keteyian, Steven; Brawner, Clinton; Ehrman, Jonathan; Sakr, Sherif

2017-01-01

Machine learning is becoming a popular and important approach in the field of medical research. In this study, we investigate the relative performance of various machine learning methods such as Decision Tree, Naïve Bayes, Logistic Regression, Logistic Model Tree and Random Forests for predicting incident diabetes using medical records of cardiorespiratory fitness. In addition, we apply different techniques to uncover potential predictors of diabetes. This FIT project study used data of 32,555 patients who are free of any known coronary artery disease or heart failure who underwent clinician-referred exercise treadmill stress testing at Henry Ford Health Systems between 1991 and 2009 and had a complete 5-year follow-up. At the completion of the fifth year, 5,099 of those patients have developed diabetes. The dataset contained 62 attributes classified into four categories: demographic characteristics, disease history, medication use history, and stress test vital signs. We developed an Ensembling-based predictive model using 13 attributes that were selected based on their clinical importance, Multiple Linear Regression, and Information Gain Ranking methods. The negative effect of the imbalance class of the constructed model was handled by Synthetic Minority Oversampling Technique (SMOTE). The overall performance of the predictive model classifier was improved by the Ensemble machine learning approach using the Vote method with three Decision Trees (Naïve Bayes Tree, Random Forest, and Logistic Model Tree) and achieved high accuracy of prediction (AUC = 0.92). The study shows the potential of ensembling and SMOTE approaches for predicting incident diabetes using cardiorespiratory fitness data.

Predicting diabetes mellitus using SMOTE and ensemble machine learning approach: The Henry Ford ExercIse Testing (FIT project.

Directory of Open Access Journals (Sweden)

Manal Alghamdi

Full Text Available Machine learning is becoming a popular and important approach in the field of medical research. In this study, we investigate the relative performance of various machine learning methods such as Decision Tree, Naïve Bayes, Logistic Regression, Logistic Model Tree and Random Forests for predicting incident diabetes using medical records of cardiorespiratory fitness. In addition, we apply different techniques to uncover potential predictors of diabetes. This FIT project study used data of 32,555 patients who are free of any known coronary artery disease or heart failure who underwent clinician-referred exercise treadmill stress testing at Henry Ford Health Systems between 1991 and 2009 and had a complete 5-year follow-up. At the completion of the fifth year, 5,099 of those patients have developed diabetes. The dataset contained 62 attributes classified into four categories: demographic characteristics, disease history, medication use history, and stress test vital signs. We developed an Ensembling-based predictive model using 13 attributes that were selected based on their clinical importance, Multiple Linear Regression, and Information Gain Ranking methods. The negative effect of the imbalance class of the constructed model was handled by Synthetic Minority Oversampling Technique (SMOTE. The overall performance of the predictive model classifier was improved by the Ensemble machine learning approach using the Vote method with three Decision Trees (Naïve Bayes Tree, Random Forest, and Logistic Model Tree and achieved high accuracy of prediction (AUC = 0.92. The study shows the potential of ensembling and SMOTE approaches for predicting incident diabetes using cardiorespiratory fitness data.

Especialización regional, integración de proveedores e impactos locales. El nuevo proyecto de expansión de Ford-Hermosillo

Directory of Open Access Journals (Sweden)

Sergio A. Sandoval Godoy

2005-01-01

Full Text Available Este artículo ofrece una explicación acerca de las razones estratégicas de la gerencia de la empresa Ford Motor Company para impulsar un nuevo proyecto de expansión productiva en Hermosillo, Sonora, en el norte de México, a partir de 2005. Entre otros aspectos, se pretende demostrar que además de los factores relacionados con las ventajas comparativas y competitivas locales ya consolidadas, la instrumentación de un nuevo modelo de proveedores es el componente estratégico más importante que actualmente determina lo s programas de especialización regional y de expansión productiva de la corporación. Dicho componente está asociado con la consolidación de un modelo de aprendizaje y desarrollo organizacional de la firma en el sector de autopartes, que implica, entre otros aspectos, intercambio mutuo de información, relaciones sociales basadas en el dominio y la confianza, y cooperación técnica directa con proveedores. Asimismo, con el fin de aprovechar cabalmente esta nueva fase en la región, se advierte sobre la necesidad de potenciar endógenamente el proyecto, y adoptar una visión proactiva de mediano y largo plazo.

Analysis of Air Force Compliance with Executive Order 13149

Science.gov (United States)

2004-03-23

Stratus x x Dodge Minivan x x x Dodge Pickup x Ford Taurus x x x x Ford Explorer x x x x Ford Ranger x x x Mazda B3000 x x x Chevrolet S10 x x Chevrolet...from General Motors, Ford , Daimler Chrysler, Toyota, Honda, and many others. Although prices vary around the country, it is estimated that, CNG will...20-40%. Nitrogen Oxides are reduced by 15-20%. Particulates are reduced by 80-95% (Triangle Clean Cities Coalition, 2003). Ford is currently

Sodium-sulfur battery development. Phase VB final report, October 1, 1981--February 28, 1985

Energy Technology Data Exchange (ETDEWEB)

NONE

1985-04-01

This report describes the technical progress made under Contract No. DE-AM04-79CH10012 between the U.S. Department of Energy, Ford Aerospace & Communications Corporations and Ford Motor Company, for the period 1 October 1981 through 28 February 1985, which is designated as Phase VB of the Sodium-Sulfur Battery Development Program. During this period, Ford Aerospace held prime technical responsibility and Ford Motor Company carried out supporting research. Ceramatec, Inc., was a major subcontractor to Ford Aerospace for electrolyte development and production.

Assessment of Water Resource Sustainability in Energy Production for Hydraulic Fracturing in the Eagle Ford Shale Play, Texas

Science.gov (United States)

Obkirchner, G.; Knappett, P.; Burnett, D.; Bhatia, M.; Mohtar, R.

2017-12-01

The Eagle Ford shale is one of the largest producers of shale oil globally. It is located in a semi-arid region of South Central Texas where hydraulic fracturing for oil and gas production accounts for 16% of total water consumption in Region L Groundwater Management Area (GMA). Because water is largely supplied through groundwater sources, it is critical to understand, monitor, and predict future groundwater budgets to keep up with growing demands from the municipal and energy sectors to improve its management and sustainability. Within the Texas A&M University Water-Energy-Food (WEF) Nexus Initiative and research group, tools have been developed that quantify the interrelations between water, energy, and transportation within Region L and calculate the environmental needs/outcomes to reach optimum levels of oil and gas production. These tools will be combined with a groundwater budget model to fully integrate groundwater limitations and enhance the resiliency of energy production. With about half of oil and gas production wells located in high to extremely high water stress areas, monitoring and modeling must be drastically improved to predict the impacts of various spatial distributions of pumping rates on future aquifer conditions. These changing conditions will impact the cost of water production in an aquifer. Combining the WEF Nexus tools with hydrologic models creates a multi-disciplinary sustainability assessment model that calculates social and economic constraints from an area's limited water resources. This model will allow industry, governments and scientists to plan through evaluating the impacts of any number of growth, conservation and reuse scenarios across different water usage sectors on groundwater supplies.

The status of water demand management in selected cities of southern Africa

Science.gov (United States)

Gumbo, Bekithemba

As a result of the rapid rate of urbanisation throughout Africa, many African cities face mounting challenges of providing their increasing populations with adequate and sustainable water services. Water demand management (WDM) offers a sustainable solution to water woes experienced in most cities in the southern Africa region. The region is characterised by frequent droughts, floods and erratic, unevenly distributed rainfall. Meanwhile nearly half of the southern Africa’s 200 million inhabitants do not have access to safe water and sanitation. This paper makes an assessment of the status of WDM in eight cities in the region based on published data and reports. It provides a basis of benchmarking the progress and success in WDM programmes by using selected key performance indicators. Gross unaccounted-for-water (UAW) is used as a crude measure of WDM good practice. From the eight selected case studies, Windhoek, Bulawayo and Hermanus have achieved considerable success in water use efficiency, implementing WDM programmes and recording UAW values of less than 20%, whilst Johannesburg; Maputo; Maseru; Lusaka and Mutare cannot account for about 40-60% of the water introduced into the distribution system. WDM projects require some key performance indicators which need to be recorded systematically by water supply agencies to enable a consistent monitoring and evaluation of programme. Finally for WDM to succeed, a new breed of professionals with multi-disciplinary skills is required as well as training of operatives, i.e. technicians, plumbers and meter readers.

77 FR 31577 - Non-Malleable Cast Iron Pipe Fittings From the People's Republic of China: Final Results of...

Science.gov (United States)

2012-05-29

... the PRC.\\3\\ On March 6, 2012, Ford Motor Company (``Ford'') requested revocation in part of the AD...''), with respect to Ford's connector. The domestic industry has affirmatively expressed a lack of interest...

Eagle Ford Shale BTEX and NOx concentrations are dominated by oil and gas industry emissions

Science.gov (United States)

Schade, G. W.; Roest, G. S.

2017-12-01

US shale oil and gas exploration has been identified as a major source of greenhouse gases and non-methane hydrocarbon (NMHC) emissions to the atmosphere. Here, we present a detailed analysis of 2015 air quality data acquired by the Texas Commission on Environmental Quality (TCEQ) at an air quality monitoring station in Karnes County, TX, central to Texas' Eagle Ford shale area. Data include time series of hourly measured NMHCs, nitrogen oxides (NOx), and hydrogen sulfide (H2S) alongside meteorological measurements. The monitor was located in Karnes City, and thus affected by various anthropogenic emissions, including traffic and oil and gas exploration sources. Highest mixing ratios measured in 2015 included nearly 1 ppm ethane, 0.8 ppm propane, alongside 4 ppb benzene. A least-squares minimization non-negative matrix factorization (NMF) analysis, tested with prior data analyzed using standard PMF-2 software, showed six major emission sources: an evaporative and fugitive source, a flaring source, a traffic source, an oil field source, a diesel source, and an industrial manufacturing source, together accounting for more than 95% of data set variability, and interpreted using NMHC composition and meteorological data. Factor scores strongly suggest that NOx emissions are dominated by flaring and associated sources, such as diesel compressor engines, likely at midstream facilities, while traffic in this rural area is a minor NOx source. The results support, but exceed existing 2012 emission inventories estimating that local traffic emitted seven times fewer NOx than oil and gas exploration sources in the county. Sources of air toxics such as the BTEX compounds are also dominated by oil and gas exploration sources, but are more equally distributed between the associated factors. Benzene abundance is only 20-40% associated with traffic sources, and may thus be 2.5-5 times higher now than prior to the shale boom in this area. Although the monitor was located relatively

Analysis of burnable poison in Ford Nuclear Reactor fuel to extend fuel lifetime. Final report, August 1, 1994--September 29, 1996

Energy Technology Data Exchange (ETDEWEB)

Burn, R.R.; Lee, J.C.

1996-12-01

The objective of the project was to establish the feasibility of extending the lifetime of fuel elements for the Ford Nuclear Reactor (FNR) by replacing current aluminide fuel with silicide fuel comprising a heavier uranium loading but with the same fissile enrichment of 19.5 wt% {sup 235}U. The project has focused on fuel designs where burnable absorbers, in the form of B{sub 4}C, are admixed with uranium silicide in fuel plates so that increases in the control reactivity requirements and peak power density, due to the heavier fuel loading, may be minimized. The authors have developed equilibrium cycle models simulating current full-size aluminide core configurations with 43 {approximately} 45 fuel elements. Adequacy of the overall equilibrium cycle approach has been verified through comparison with recent FNR experience in spent fuel discharge rates and simulation of reactor physics characteristics for two representative cycles. Fuel cycle studies have been performed to compare equilibrium cycle characteristics of silicide fuel designs, including burnable absorbers, with current aluminide fuel. These equilibrium cycle studies have established the feasibility of doubling the fuel element lifetime, with minimal perturbations to the control reactivity requirements and peak power density, by judicious additions of burnable absorbers to silicide fuel. Further study will be required to investigate a more practical silicide fuel design, which incorporates burnable absorbers in side plates of each fuel element rather than uniformly mixes them in fuel plates.

RECENT DEVELOPMENT

Institute of Scientific and Technical Information of China (English)

1994-01-01

<正> Ford Revealed China Strategy Ford plans to enhance its efforts in China in accordance with the industrial policy, more joint ventures on components and complete vehicles are to be closely followed. Ford looks China as its strategic produc

The Nature of Temporally Variable Methane Emissions at Oil and Natural Gas Operations in the Eagle Ford Basin

Science.gov (United States)

Lavoie, T. N.; Shepson, P. B.; Cambaliza, M. O. L.; Stirm, B. H.; Conley, S. A.; Mehrotra, S.; Faloona, I. C.; Mayfield, M.; Lyon, D. R.; Alvarez, R.

2015-12-01

To understand the current state of U.S. greenhouse gas emissions from oil and gas operations, policy makers refer to national inventories and reporting programs, and therefore, it is imperative that these reports are accurate and representative. Many studies exist that investigate the reliability of current monitoring methods, however, to our knowledge the temporal variability of the magnitude and source of methane (CH4) emissions from oil and gas facilities has not been reported in the literature. We present results from a field campaign conducted in June 2014 in the Eagle Ford basin, Texas to assess the temporal variability of emissions from a variety of facilities using data obtained through four different methods. The variability of total CH4 emission rate from individual facilities was investigated by repeated measurement of emissions from five gathering facilities using two aircraft-based mass balance approaches. Basin-wide emissions variation was examined by conducting a series of eight four hour afternoon aerial surveys of two 35 x 35 km areas, with transects oriented perpendicular to the prevailing wind direction. The emission source-type and magnitude were further investigated using helicopter-based FLIR camera observations conducted repeatedly at eight oil wells, one gas well, and four gathering facilities. Results indicate a high degree of variability in day-to-day and sometimes hour-to-hour CH4 emissions magnitude. FLIR camera observations suggest that the component-level source of facility emissions is also highly variable over time, with both storage tank vent stacks and tank hatches representing important components of the observed day-to-day variability. While some emissions were due to scheduled maintenance, others appeared to occur due to faulty and/or aging equipment. Here we discuss what was learned in terms of factors that explain the observed emission rate variability.

Formulation of a correlated variables methodology for assessment of continuous gas resources with an application to the Wood ford play, Arkoma Basin, eastern Oklahoma

Energy Technology Data Exchange (ETDEWEB)

Olea, R. A.; Houseknecht, D. W.; Garrity, C. P.; Cook, T. A.

2011-07-01

Shale gas is a form of continuous unconventional hydrocarbon accumulation whose resource estimation is unfeasible through the inference of pore volume. Under these circumstances, the usual approach is to base the assessment on well productivity through estimated ultimate recovery (EUR). Unconventional resource assessments that consider uncertainty are typically done by applying analytical procedures based on classical statistics theory that ignores geographical location, does not take into account spatial correlation, and assumes independence of EUR from other variables that may enter into the modeling. We formulate a new, more comprehensive approach based on sequential simulation to test methodologies known to be capable of more fully utilizing the data and overcoming unrealistic simplifications. Theoretical requirements demand modeling of EUR as areal density instead of well EUR. The new experimental methodology is illustrated by evaluating a gas play in the Wood ford Shale in the Arkoma Basin of Oklahoma. Differently from previous assessments, we used net thickness and vitrinite reflectance as secondary variables correlated to cell EUR. In addition to the traditional probability distribution for undiscovered resources, the new methodology provides maps of EUR density and maps with probabilities to reach any given cell EUR, which are useful to visualize geographical variations in prospectivity. (Author) 21 refs.

Tippvormis Harrison Ford / Harrison Ford ; toim. Robert Aps

Index Scriptorium Estoniae

Ford, Harrison

2008-01-01

Näitleja järjekordse Indiana Jones'i filmi "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") väljatuleku eel. Sama ka Teleleht nr. 23, lk. 47 : ill

On the implementation of the Ford | Fulkerson algorithm on the Multiple Instruction and Single Data computer system

Directory of Open Access Journals (Sweden)

A. Yu. Popov

2014-01-01

Full Text Available Algorithms of optimization in networks and direct graphs find a broad application when solving the practical tasks. However, along with large-scale introduction of information technologies in human activity, requirements for volumes of input data and retrieval rate of solution are aggravated. In spite of the fact that by now the large number of algorithms for the various models of computers and computing systems have been studied and implemented, the solution of key problems of optimization for real dimensions of tasks remains difficult. In this regard search of new and more efficient computing structures, as well as update of known algorithms are of great current interest.The work considers an implementation of the search-end algorithm of the maximum flow on the direct graph for multiple instructions and single data computer system (MISD developed in BMSTU. Key feature of this architecture is deep hardware support of operations over sets and structures of data. Functions of storage and access to them are realized on the specialized processor of structures processing (SP which is capable to perform at the hardware level such operations as: add, delete, search, intersect, complete, merge, and others. Advantage of such system is possibility of parallel execution of parts of the computing tasks regarding the access to the sets to data structures simultaneously with arithmetic and logical processing of information.The previous works present the general principles of the computing process arrangement and features of programs implemented in MISD system, describe the structure and principles of functioning the processor of structures processing, show the general principles of the graph task solutions in such system, and experimentally study the efficiency of the received algorithms.The work gives command formats of the SP processor, offers the technique to update the algorithms realized in MISD system, suggests the option of Ford-Falkersona algorithm

Study on Ballistic Absorbing Energy Character of High Performance Polyethylene Needle Felt

Science.gov (United States)

Kailiang, Zhu; Jianqiao, Fu

2017-11-01

The ballistic performance of polyethylene needle felt is tested and the failure morphology after test is also observed. The results showed that when the non-dimensionally non-stressed fibers in polyethylene needles are subjected to high-speed projectile, secondary movement such as stretching and twisting occurs first. This secondary movement is very full, it is the main way of ballistic absorbing energy of the polyethylene needle felt which can avoid the polyethylene fiber short-term rapid heating-up and destroyed. Analysis results show that under normal temperature and humidity conditions, the V50 of 6-layer forded polyethylene needle felt sample is 250m/s. At (450 ± 50) m/s speed range of the target missile, the mean value of the penetrative specific energy absorption for 3-layer forded polyethylene needle felt anti-1.1g simulated projectiles (tapered column) reaches 24.1J·m2/kg.

77 FR 43216 - Denial of Motor Vehicle Defect Petition and Petition for a Hearing

Science.gov (United States)

2012-07-24

... hearing to address whether Ford Motor Company (Ford) and Mazda North American Operations (Mazda) met their... Denial of Motor Vehicle Defect Petition and Petition for a Hearing AGENCY: National Highway Traffic... petitioned NHTSA to open defect investigations on Model Year (MY) 2002-2004 Ford Escape and 2001-2004 Mazda...

Hydraulic Fracturing and Production Optimization in Eagle Ford Shale Using Coupled Geomechanics and Fluid Flow Model

Science.gov (United States)

Suppachoknirun, Theerapat; Tutuncu, Azra N.

2017-12-01

With increasing production from shale gas and tight oil reservoirs, horizontal drilling and multistage hydraulic fracturing processes have become a routine procedure in unconventional field development efforts. Natural fractures play a critical role in hydraulic fracture growth, subsequently affecting stimulated reservoir volume and the production efficiency. Moreover, the existing fractures can also contribute to the pressure-dependent fluid leak-off during the operations. Hence, a reliable identification of the discrete fracture network covering the zone of interest prior to the hydraulic fracturing design needs to be incorporated into the hydraulic fracturing and reservoir simulations for realistic representation of the in situ reservoir conditions. In this research study, an integrated 3-D fracture and fluid flow model have been developed using a new approach to simulate the fluid flow and deliver reliable production forecasting in naturally fractured and hydraulically stimulated tight reservoirs. The model was created with three key modules. A complex 3-D discrete fracture network model introduces realistic natural fracture geometry with the associated fractured reservoir characteristics. A hydraulic fracturing model is created utilizing the discrete fracture network for simulation of the hydraulic fracture and flow in the complex discrete fracture network. Finally, a reservoir model with the production grid system is used allowing the user to efficiently perform the fluid flow simulation in tight formations with complex fracture networks. The complex discrete natural fracture model, the integrated discrete fracture model for the hydraulic fracturing, the fluid flow model, and the input dataset have been validated against microseismic fracture mapping and commingled production data obtained from a well pad with three horizontal production wells located in the Eagle Ford oil window in south Texas. Two other fracturing geometries were also evaluated to optimize

76 FR 14972 - Granting of Request for Early Termination of the Waiting Period Under the Premerger Notification...

Science.gov (United States)

2011-03-18

... William Clay Ford, Jr.; Ford Motor Company; William Clay Ford, Jr. 20110535 G Rock-Tenn Company; Smurfit-Stone Container Corporation; Rock-Tenn Company. 02/07/2011 20110383 G Paychex, Inc.; SurePayroll, Inc... 20110513 G General Electric Company; Gores Capital Partners II, L.P.; General Electric Company. 02/09/2011...

40 CFR 85.2217 - Loaded test-EPA 91.

Science.gov (United States)

2010-07-01

.... (1) Loaded mode—(i) Ford Motor Company and Honda vehicles. (Optional.) The engines of 1981-1987 model year Ford Motor Company vehicles and 1984-1985 model year Honda Preludes must be shut off for not more... Motor Company and Honda vehicles. (Optional.) The engines of 1981-1987 model year Ford Motor Company...

40 CFR 85.2218 - Preconditioned idle test-EPA 91.

Science.gov (United States)

2010-07-01

.... (2) Idle mode—(i) Ford Motor Company and Honda vehicles. The engines of 1981-1987 model year Ford Motor Company vehicles and 1984-1985 model year Honda Preludes must be shut off for not more than ten...-1989 model year Ford Motor Company vehicles but may not be used for other vehicles. (ii) The mode timer...

77 FR 22562 - Non-Malleable Cast Iron Pipe Fittings From the People's Republic of China: Initiation and...

Science.gov (United States)

2012-04-16

... section 751(b) of the Tariff Act of 1930, as amended (the Act), and 19 CFR 351.216(b), Ford Motor Company (Ford) filed a request for a changed circumstances review of the antidumping duty (AD) order on non... PRC.\\1\\ On March 6, 2012, Ford requested revocation in part of the AD order pursuant to sections 751(b...

Application of Advanced Reservoir Characterization, Simulation, and Production Optimization Strategies to Maximize Recovery in Slope and Basin Clastic Reservoirs, West Texas (Delaware Basin), Class III

Energy Technology Data Exchange (ETDEWEB)

Dutton, Shirley P.; Flanders, William A.

2001-11-04

The objective of this Class III project was demonstrate that reservoir characterization and enhanced oil recovery (EOR) by CO2 flood can increase production from slope and basin clastic reservoirs in sandstones of the Delaware Mountain Group in the Delaware Basin of West Texas and New Mexico. Phase 1 of the project, reservoir characterization, focused on Geraldine Ford and East Ford fields, which are Delaware Mountain Group fields that produce from the upper Bell Canyon Formation (Ramsey sandstone). The demonstration phase of the project was a CO2 flood conducted in East Ford field, which is operated by Orla Petco, Inc., as the East Ford unit.

Smoother Sailing Ahead: Integrating Information Technology into the Surface Navy.

Science.gov (United States)

1994-09-01

foreign competition, Ford Motor Company examined many areas of its operations. In its supply procurement division Ford employed over 500 personnel...generating reams of paperwork that contained many inventory discrepancies and billing errors. Mazda Motors in Japan performed the same function better...with five employees. (Schnitt, 1993, p. 19) The competition forced Ford to adopt new methods using modem information technology. Instead of pieces of

40 CFR 85.2219 - Idle test with loaded preconditioning-EPA 91.

Science.gov (United States)

2010-07-01

... (5.1-6.3). 7 or more 32-35 (52-56) 8.4-10.8 (6.3-8.1). (2) Idle mode—(i) Ford Motor Company and Honda vehicles. (Optional.) The engines of 1981-1987 model year Ford Motor Company vehicles and 1984-1985 model... also be used for 1988-1989 model year Ford Motor Company vehicles but may not be used for other...

Application of Advanced Reservoir Characterization, Simulation, and Production Optimization Strategies to Maximize Recovery in Slope and Basin Clastic Reservoirs, West Texas (Delaware Basin)

Energy Technology Data Exchange (ETDEWEB)

Dutton, S.P.; Flanders, W.A.; Guzman, J.I.; Zirczy, H.

1999-06-08

The objective of this Class III project is to demonstrate that detailed reservoir characterization of slope and basin clastic reservoirs in sandstones of the Delaware Mountain Group in the Delaware Basin of West Texas and New Mexico is a cost-effective way to recover a higher percentage of the original oil in place through geologically based field development. This year the project focused on reservoir characterization of the East Ford unit, a representative Delaware Mountain Group field that produces from the upper Bell Canyon Formation (Ramsey Sandstone). The field, discovered in 1960, is operated by Orla Petco, Inc., as the East Ford unit; it contained an estimated 19.8 million barrels (MMbbl) of original oil in place. Petrophysical characterization of the East Ford unit was accomplished by integrating core and log data and quantifying petrophysical properties from wireline logs. Most methods of petrophysical analysis that had been developed during an earlier study of the Ford Geraldine unit were successfully transferred to the East Ford unit. The approach that was used to interpret water saturation from resistivity logs, however, had to be modified because in some East Ford wells the log-calculated water saturation was too high and inconsistent with observations made during the actual production. Log-porosity to core-porosity transforms and core-porosity to core-permeability transforms were derived from the East Ford reservoir. The petrophysical data were used to map porosity, permeability, net pay, water saturation, mobil-oil saturation, and other reservoir properties.

Comparison of machine learning techniques to predict all-cause mortality using fitness data: the Henry ford exercIse testing (FIT) project.

Science.gov (United States)

Sakr, Sherif; Elshawi, Radwa; Ahmed, Amjad M; Qureshi, Waqas T; Brawner, Clinton A; Keteyian, Steven J; Blaha, Michael J; Al-Mallah, Mouaz H

2017-12-19

Prior studies have demonstrated that cardiorespiratory fitness (CRF) is a strong marker of cardiovascular health. Machine learning (ML) can enhance the prediction of outcomes through classification techniques that classify the data into predetermined categories. The aim of this study is to present an evaluation and comparison of how machine learning techniques can be applied on medical records of cardiorespiratory fitness and how the various techniques differ in terms of capabilities of predicting medical outcomes (e.g. mortality). We use data of 34,212 patients free of known coronary artery disease or heart failure who underwent clinician-referred exercise treadmill stress testing at Henry Ford Health Systems Between 1991 and 2009 and had a complete 10-year follow-up. Seven machine learning classification techniques were evaluated: Decision Tree (DT), Support Vector Machine (SVM), Artificial Neural Networks (ANN), Naïve Bayesian Classifier (BC), Bayesian Network (BN), K-Nearest Neighbor (KNN) and Random Forest (RF). In order to handle the imbalanced dataset used, the Synthetic Minority Over-Sampling Technique (SMOTE) is used. Two set of experiments have been conducted with and without the SMOTE sampling technique. On average over different evaluation metrics, SVM Classifier has shown the lowest performance while other models like BN, BC and DT performed better. The RF classifier has shown the best performance (AUC = 0.97) among all models trained using the SMOTE sampling. The results show that various ML techniques can significantly vary in terms of its performance for the different evaluation metrics. It is also not necessarily that the more complex the ML model, the more prediction accuracy can be achieved. The prediction performance of all models trained with SMOTE is much better than the performance of models trained without SMOTE. The study shows the potential of machine learning methods for predicting all-cause mortality using cardiorespiratory fitness

40 CFR 85.2201 - Applicability.

Science.gov (United States)

2010-07-01

... for Ford Motor Company and Honda Prelude vehicles. Due to unique emission control systems, 1981 through 1987 model year vehicles manufactured by Ford Motor Company and 1984 through 1985 model year Honda...

Modular Electric Vehicle Program (MEVP). Final technical report

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-03-01

The Modular Electric Vehicle Program (MEVP) was an EV propulsion system development program in which the technical effort was contracted by DOE to Ford Motor Company. The General Electric Company was a major subcontractor to Ford for the development of the electric subsystem. Sundstrand Power Systems was also a subcontractor to Ford, providing a modified gas turbine engine APU for emissions and performance testing as well as a preliminary design and producibility study for a Gas Turbine-APU for potential use in hybrid/electric vehicles. The four-year research and development effort was cost-shared between Ford, General Electric, Sundstrand Power Systems and DOE. The contract was awarded in response to Ford`s unsolicited proposal. The program objective was to bring electric vehicle propulsion system technology closer to commercialization by developing subsystem components which can be produced from a common design and accommodate a wide range of vehicles; i.e., modularize the components. This concept would enable industry to introduce electric vehicles into the marketplace sooner than would be accomplished via traditional designs in that the economies of mass production could be realized across a spectrum of product offerings. This would eliminate the need to dedicate the design and capital investment to a limited volume product offering which would increase consumer cost and/or lengthen the time required to realize a return on the investment.

[Target volume margins for lung cancer: internal target volume/clinical target volume].

Science.gov (United States)

Jouin, A; Pourel, N

2013-10-01

The aim of this study was to carry out a review of margins that should be used for the delineation of target volumes in lung cancer, with a focus on margins from gross tumour volume (GTV) to clinical target volume (CTV) and internal target volume (ITV) delineation. Our review was based on a PubMed literature search with, as a cornerstone, the 2010 European Organisation for Research and Treatment of Cancer (EORTC) recommandations by De Ruysscher et al. The keywords used for the search were: radiotherapy, lung cancer, clinical target volume, internal target volume. The relevant information was categorized under the following headings: gross tumour volume definition (GTV), CTV-GTV margin (first tumoural CTV then nodal CTV definition), in field versus elective nodal irradiation, metabolic imaging role through the input of the PET scanner for tumour target volume and limitations of PET-CT imaging for nodal target volume definition, postoperative radiotherapy target volume definition, delineation of target volumes after induction chemotherapy; then the internal target volume is specified as well as tumoural mobility for lung cancer and respiratory gating techniques. Finally, a chapter is dedicated to planning target volume definition and another to small cell lung cancer. For each heading, the most relevant and recent clinical trials and publications are mentioned. Copyright © 2013. Published by Elsevier SAS.

Learning Distance Functions for Exemplar-Based Object Recognition

Science.gov (United States)

2007-08-08

1962 Ferrari 250 Ferrari 348T Ferrari F40 Ferrari F50 Fiat 500 Ford GT90 Ford Mustang GT London Taxi Ford GT40 1984 Ferrari GTO Toyota Land Cruiser...BMW Isetta 250 Jaguar Jaguar XJ 220 1968 VW Karmann Ghia Lamborghini Countach 1995 Lancia Aurelia B24 Spider Toyota Lucida Mercedes 300 SE Mercedes 300...SL Mercedes A-Class Mercedes S600 Messerschmitt KR 200 1964 Mini Coopers Mustang Mark III Nissan Patrol GR Honda NSX Porsche 356 Honda Prelude Renault

Translations on Narcotics and Dangerous Drugs, Number 296.

Science.gov (United States)

1977-04-27

Mazda Familia car with license plate H-2115 in front of the cooperative barber shop on Latha Street this morning. They seized 5 grams of heroin in 15...pesos on the black market. The police also illegally seized a 1963 Ford stake bed truck and a 1971 Ford truck belonging to the La Sierrita ejido...security service jeeps, disguised in the clothing worn by guards. Investigators claimed that they transferred from the jeep to a brown Ford LTD in the

Ford og fordismen

DEFF Research Database (Denmark)

Wagner, Michael

2010-01-01

Stort set alle politiske retninger, fra kommunisme til fascisme, såvel som demokratiske samfund, var tiltrukket af fordismen i teori og praksis.s......Stort set alle politiske retninger, fra kommunisme til fascisme, såvel som demokratiske samfund, var tiltrukket af fordismen i teori og praksis.s...

Water use competition scenarios during the upcoming development of shale gas reserves across the Mexican Eagle Ford play Image already added

Science.gov (United States)

Arciniega, S.; Breña-Naranjo, J. A.; Hernaández Espriú, A.; Pedrozo-Acuña, A.

2017-12-01

Mexico has significant shale oil and gas resources mainly contained within the Mexican part of the Eagle Ford play (Mex-EF), in the Burgos Basin located in northern Mexico. Over the last years, concerns about the water use associated to shale gas development using hydraulic fracturing (HF) have been increasing in the United States and Canada. In Mexico, the recent approval of a new energy bill allows the exploration, development and production of shale gas reserves. However, several of the Mexican shale gas resources are located in water-limited environments, such as the Mex-EF. The lack of climate and hydrological gauging stations across this region constrains information about how much freshwater from surface and groundwater sources is available and whether its interannual water availability is sufficient to satisfy the water demand by other users (agricultural, urban) of the region This work projects the water availability across the Mex-EF and its water use derived from the expansion of unconventional gas developments over the next 15 years. Water availability is estimated using a water balance approach, where the irrigation's groundwater withdrawals time series were reconstructed using remote sensing products (vegetation index and hydrological outputs from LSMs) and validated with in situ observed water use at three different irrigation districts of the region. Water use for HF is inferred using type curves of gas production, flowback and produced (FP) water and curves of drilled wells per year from the US experience, mainly from the Texas-EF play. Scenarios that combine freshwater use and FP water use for HF are developed and the spatial distribution of HF well pads is projected using random samples with a range of wells' horizontal length. This proposed methodology can be applied in other shale formations of the world under water stress and it also helps to determine whether water scarcity can be a limiting factor for the shale gas industry over the next

Molecular Targets for Targeted Radionuclide Therapy

International Nuclear Information System (INIS)

Mather, S.J.

2009-01-01

Molecular targeted radionuclide cancer therapy is becoming of increasing importance, especially for disseminated diseases. Systemic chemotherapies often lack selectivity while targeted radionuclide therapy has important advantages as the radioactive cytotoxic unit of the targeting vector is specifically directed to the cancer, sparing normal tissues. The principle strategy to improve cancer selectivity is to couple therapeutic agents to tumour-targeting vectors. In targeted radionuclide therapy (TRT), the cytotoxic portion of the conjugates normally contains a therapeutic radiometal immobilised by a bifunctional chelator. The aim is therefore to use as ligand-targeted therapeutics vectors coupled to Auger-, alpha- and/or beta-emitting radionuclides. An advantage of using radiation instead of chemotherapeutics as the cytotoxic agent is the so called 'crossfire effect'. This allows sterilisation of tumour cells that are not directly targeted due to heterogeneity in target molecule expression or inhomogeneous vector delivery. However, before the targeting ligands can be selected, the target molecule on the tumour has to be selected. It should be uniquely expressed, or at least highly overexpressed, on or in the target cells relative to normal tissues. The target should be easily accessible for ligand delivery and should not be shed or down- regulated after ligand binding. An important property of a receptor (or antigen) is its potential to be internalized upon binding of the ligand. This provides an active uptake mechanism and allows the therapeutic agent to be trapped within the tumour cells. Molecular targets of current interest include: Receptors: G-protein coupled receptors are overexpressed on many major human tumours. The prototype of these receptors are somatostatin receptors which show very high density in neuroendocrine tumours, but there are many other most interesting receptors to be applied for TRT. The targeting ligands for these receptors are

Program "Whip Inflation Now" a jeho vliv na inflaci a nezaměstnanost v USA v 70. letech

OpenAIRE

Sirový, Michal

2012-01-01

The topic of this thesis is the Gerald Ford's program WIN as a policy aimed at inflation. WIN is certainly determined by the time it was developer in. The essential aspects are unemployment rate, which had reached 9 percents in the 1970s, and the neglect of monetary policy. Ford's announced policy was the exact opposite of that of Nixon's. The infamous saving in the times of crisis was relatively mild, thus the speculations of an attempt of Ford's PR is an explanation. The CPI level had lower...

Inner bremsstrahlung accompanying β-decay of 170Tm

International Nuclear Information System (INIS)

Gundu Rao, K.S.; Venkataramaiah, P.; Gopala, K.; Sanjeeviah, H.

1981-01-01

Inner bremsstrahlung accompanying non-unique first-forbidden β-decay of 170 Tm has been measured employing a magnetic deflection technique with a (4.5 x 5.1 cm) NaI(Tl) scintillation spectrometer in the energy region 200 keV to 900 keV. The raw spectrum is unfolded using the Liden and Starfelt procedure, and compared with the theories of KUB, Lewis and Ford, and Ford and Martin. The results are close to the Lewis and Ford theory over the major portion of the measured spectrum. (orig.)

Harrison Ford : opjat skripit potertoje sedlo... / Harrison Ford ; interv. Barbara Hanson

Index Scriptorium Estoniae

Ford, Harrison

2008-01-01

Näitleja järjekordse (arvult neljanda, 19-aastase vaheaja järel!) Indiana Jones'i filmi "Indiana Jones ja kristallpealuu kuningriik" ("Indiana Jones and the Kingdom of the Crystal Skull") väljatuleku eel. Väljaandest Famous

77 FR 729 - Airworthiness Directives; Enstrom Helicopter Corporation Helicopters

Science.gov (United States)

2012-01-06

... to the specified helicopters with a reversible trim motor, P/N 28-16621 (Ford Motor Company C1AZ... helicopters with a reversible trim motor, P/N 28-16621 (Ford Motor Company C1AZ- 14553A) or P/N AD1R-10...

Application of advanced reservoir characterization, simulation and production optimization strategies to maximize recovery in slope and basin clastic reservoirs, West Texas (Delaware Basin). Annual report

Energy Technology Data Exchange (ETDEWEB)

Dutton, S.P.; Asquith, G.B.; Barton, M.D.; Cole, A.G.; Gogas, J.; Malik, M.A.; Clift, S.J.; Guzman, J.I.

1997-11-01

The objective of this project is to demonstrate that detailed reservoir characterization of slope and basin clastic reservoirs in sandstones of the Delaware Mountain Group in the Delaware Basin of West Texas and New Mexico is a cost-effective way to recover a higher percentage of the original oil in place through strategic placement of infill wells and geologically based field development. This project involves reservoir characterization of two Late Permian slope and basin clastic reservoirs in the Delaware Basin, West Texas, followed by a field demonstration in one of the fields. The fields being investigated are Geraldine Ford and Ford West fields in Reeves and Culberson Counties, Texas. Project objectives are divided into two major phases, reservoir characterization and implementation. The objectives of the reservoir characterization phase of the project were to provide a detailed understanding of the architecture and heterogeneity of the two fields, the Ford Geraldine unit and Ford West field. Reservoir characterization utilized 3-D seismic data, high-resolution sequence stratigraphy, subsurface field studies, outcrop characterization, and other techniques. Once reservoir characterized was completed, a pilot area of approximately 1 mi{sup 2} at the northern end of the Ford Geraldine unit was chosen for reservoir simulation. This report summarizes the results of the second year of reservoir characterization.

Salt formations offer disposal alternative

International Nuclear Information System (INIS)

Funderburk, R.

1990-01-01

This paper discusses how three U.S. firms are spending millions to permit and build underground disposal sites in salt formations. These companies claim salt is the ideal geological medium for holding hazardous wastes. Two Texas locations and one in Michigan have been targeted as future sites for hazardous waste disposal. The Michigan site, outside Detroit, is a former salt mine 2,000 feet beneath the Ford Motor Co. (Detroit) assembly works in Dearborn. Both Texas sites are atop salt domes---one east and one west of Houston

76 FR 62790 - Combined Notice of Filings #1

Science.gov (United States)

2011-10-11

... Tuesday, October 18, 2011. Docket Numbers: ER11-4651-000. Applicants: Ford Motor Company. Description: Notice of Termination of Ford Motor Company. Filed Date: 09/27/2011. Accession Numbers: 20110927-5136... England Power Company. Description: New England Power Company submits tariff filing per 35.17(b...

Kubens fascination

DEFF Research Database (Denmark)

Skude, Flemming

2002-01-01

Anmeldelse af Nykredits domicil på Kalvebod Brygge referende til Ford Foundation i New York og nutidens præference for minimalistisk kubisme.......Anmeldelse af Nykredits domicil på Kalvebod Brygge referende til Ford Foundation i New York og nutidens præference for minimalistisk kubisme....

Human dignity and the future of the voluntary active euthanasia debate in South Africa.

Science.gov (United States)

Jordaan, Donrich W

2017-04-25

The issue of voluntary active euthanasia was thrust into the public policy arena by the Stransham-Ford lawsuit. The High Court legalised voluntary active euthanasia - however, ostensibly only in the specific case of Mr Stransham-Ford. The Supreme Court of Appeal overturned the High Court judgment on technical grounds, not on the merits. This means that in future the courts can be approached again to consider the legalisation of voluntary active euthanasia. As such, Stransham-Ford presents a learning opportunity for both sides of the legalisation divide. In particular, conceptual errors pertaining to human dignity were made in Stransham-Ford, and can be avoided in future. In this article, I identify these errors and propose the following three corrective principles to inform future debate on the subject: (i) human dignity is violable; (ii) human suffering violates human dignity; and (iii) the 'natural' causes of suffering due to terminal illness do not exclude the application of human dignity.

Human dignity and the future of the voluntary active euthanasia debate in South Africa

Directory of Open Access Journals (Sweden)

Donrich W Jordaan

2017-05-01

Full Text Available The issue of voluntary active euthanasia was thrust into the public policy arena by the Stransham-Ford lawsuit. The High Court legalised voluntary active euthanasia – however, ostensibly only in the specific case of Mr Stransham-Ford. The Supreme Court of Appeal overturned the High Court judgment on technical grounds, not on the merits. This means that in future the courts can be approached again to consider the legalisation of voluntary active euthanasia. As such, Stransham-Ford presents a learning opportunity for both sides of the legalisation divide. In particular, conceptual errors pertaining to human dignity were made in Stransham-Ford, and can be avoided in future. In this article, I identify these errors and propose the following three corrective principles to inform future debate on the subject: (i human dignity is violable; (ii human suffering violates human dignity; and (iii the ‘natural’ causes of suffering due to terminal illness do not exclude the application of human dignity.

Reduceret fosforindhold i foder til søer

DEFF Research Database (Denmark)

Sørensen, Gunner; Poulsen, Hanne Damgaard

2011-01-01

Foderblandinger med et gennemsnitligt indhold på 5,4 gram total-fosfor pr. FEs (Forsøg) blev sammenlignet med foderblandinger med et gennemsnitligt indhold på 6,5 gram total-fosfor pr. FEs (Kontrol). Blandingerne havde et indhold af calcium på omkring 7,2 gram pr. FEs. Af­prøvningen blev gennemført......- og balanceforsøg på Danmarks JordbrugsForskning (tidligere Statens Husdyrbrugsforsøg). Der blev fundet et lidt lavere indhold af fordøjeligt fosfor end beregnet. Der var ikke effekt af at reducere indholdet af fordøjeligt fosfor i foder på de opnåede produktionsresultater i diegivningsperioden...... moderegen­skaber, reproduktion eller holdbarhed, når foderets indhold af fosfor blev reduceret til 5,4 g total-fosfor pr. FEs, svarende til et indhold - bestemt ved fordøjelighedsforsøg på Danmarks JordbrugsFor­skning, Foulum - på omkring 2,5 g ford. fosfor pr. FEs....

Update on the Vancouver Fuel Cell Vehicle Program

International Nuclear Information System (INIS)

Rothwell, B.

2004-01-01

'Full text:' The Vancouver Fuel Cell Vehicle Program (VFCVP) is a $5.8 million initiative designed to test four Ford Focus Fuel Cell Vehicles for three years in the Lower Mainland of British Columbia. The project is the first of its kind in Canada and is led by Fuel Cells Canada (FCC), the Ford Motor Company (Ford), and the Governments of Canada and British Columbia. This presentation will provide program details and an update on activities leading up to currently planned delivery to Vancouver in November 2004. The VFCVP will test the performance, durability and reliability of the Ford fuel cell vehicle cars in real-world conditions and will examine fuelling issues and solutions, the reduction of greenhouse gas emissions and public acceptance of hydrogen fuel cell vehicles. The program will generate data to help evolve the technology and develop international codes and standards E cents Epnd the implementation and adoption of fuel cell technology. (author)

Organelle targeting: third level of drug targeting

Directory of Open Access Journals (Sweden)

Sakhrani NM

2013-07-01

Full Text Available Niraj M Sakhrani, Harish PadhDepartment of Cell and Molecular Biology, BV Patel Pharmaceutical Education and Research Development (PERD Centre, Gujarat, IndiaAbstract: Drug discovery and drug delivery are two main aspects for treatment of a variety of disorders. However, the real bottleneck associated with systemic drug administration is the lack of target-specific affinity toward a pathological site, resulting in systemic toxicity and innumerable other side effects as well as higher dosage requirement for efficacy. An attractive strategy to increase the therapeutic index of a drug is to specifically deliver the therapeutic molecule in its active form, not only into target tissue, nor even to target cells, but more importantly, into the targeted organelle, ie, to its intracellular therapeutic active site. This would ensure improved efficacy and minimize toxicity. Cancer chemotherapy today faces the major challenge of delivering chemotherapeutic drugs exclusively to tumor cells, while sparing normal proliferating cells. Nanoparticles play a crucial role by acting as a vehicle for delivery of drugs to target sites inside tumor cells. In this review, we spotlight active and passive targeting, followed by discussion of the importance of targeting to specific cell organelles and the potential role of cell-penetrating peptides. Finally, the discussion will address the strategies for drug/DNA targeting to lysosomes, mitochondria, nuclei and Golgi/endoplasmic reticulum.Keywords: intracellular drug delivery, cancer chemotherapy, therapeutic index, cell penetrating peptides

36 CFR 261.77 - Prohibitions in Region 8, Southern Region.

Science.gov (United States)

2010-07-01

... Service Registration Stations abutting the Chattooga River located at Highway 28, Low-Water Bridge, Earl's Ford, Sandy Ford, Highway 76, Woodall Shoals, or Overflow Bridge or unless authorized under special use... this section is prohibited. (d) Entering, going, riding, or floating upon any portion or segment of the...

77 FR 24762 - Mitsubishi Motors North America, Inc., Grant of Petition for Decision of Inconsequential...

Science.gov (United States)

2012-04-25

... instruction standards. Refer to Hyundai Motor Company (74 FR 9125, March 2, 209); Ford Motor Company (73 FR 11462, March 3, 2008); Mazda North America Operations (73 FR 11464, March 3, 2008); Ford Motor Company...-0176; Notice 2] Mitsubishi Motors North America, Inc., Grant of Petition for Decision of...

Chuaria circularis from the early Mesoproterozoic Suket Shale ...

Indian Academy of Sciences (India)

The origin and nature of Chuaria circularis has long been a topic of debate in Precambrian paleo- ... inorganic remains in various studies (see Hofmann. 1992). Ford and Breed (1973) concluded that. Chuaria was a plant, ..... and may be diagnostic criterion and argued that the marginal flange described by Ford and Breed.

A Benchmark Study of Large Contract Supplier Monitoring Within DOD and Private Industry

Science.gov (United States)

1994-03-01

capability to improve their processes, Ford took a tip from Mazda (25t owned by Ford) and established a technical assistance branch within their buying...thorough assessment of a company’s financial viability prior to contract award), on a contractor which had a long history of successful 72 Ii Government

76 FR 48009 - Federal Motor Vehicle Safety Standards; Lamps, Reflective Devices, and Associated Equipment

Science.gov (United States)

2011-08-08

... (AAM), Ford Motor Company (Ford), Nissan North America (Nissan), Toyota Motor North America (Toyota... ``* * * of multiple compartment lamps or * * *''. Toyota requested that paragraph S14.3.1 be modified to use... photometric requirements of DRLs. Valeo claimed that there is no way to reconcile Table 1 of SAE J222 (DEC...

Human dignity and the future of the voluntary active euthanasia ...

African Journals Online (AJOL)

The issue of voluntary active euthanasia was thrust into the public policy arena by the Stransham-Ford lawsuit. The High Court legalised voluntary active euthanasia – however, ostensibly only in the specific case of Mr Stransham-Ford. The Supreme Court of Appeal overturned the High Court judgment on technical grounds, ...

Operational forest stream crossings effects on water quality in the Virginia Piedmont

Science.gov (United States)

Wallace M. Aust; Matthew B. Carroll; M. Chad Bolding; Andy Dolloff

2011-01-01

Water quality indices were examined for paired upstream and downstream samples for 23 operational stream crossings and approaches during four periods. Stream crossings were (1) portable bridges (BRIDGE), (2) culverts backfilled with poles (POLE), (3) culverts with earth backfill (CULVERT), and (4) reinforced fords (FORD). The four operational periods were (1) prior to...

New treatment options for severe Arvophillia

International Development Research Centre (IDRC) Digital Library (Canada)

Carrie-Anne Whyte

Adaptation practice and policy. Climate change hotspots in South and Central Asia and Africa. Arctic North Consulting, 2012. Our role: 1. methodological consultants. 2. systematic review of adaptation practice and policy literature. Our team: • James Ford. • Lea Berrang –Ford. • Anna Bunce. • Maya Irwin. • Courtney McKay ...

Moral leaders in the making

DEFF Research Database (Denmark)

Mehlsen, Camilla

2009-01-01

Dr. Joan Dassin and Dr. Fulvia Rosemberg explain how the Ford Foundation International Fellowships Program has an impact on social justice and contributes to 'brain gain'.......Dr. Joan Dassin and Dr. Fulvia Rosemberg explain how the Ford Foundation International Fellowships Program has an impact on social justice and contributes to 'brain gain'....

Heavy-ion targets

International Nuclear Information System (INIS)

Adair, H.L.; Kobisk, E.H.

1985-01-01

This chapter examines the characteristics of targets required in heavy-ion accelerator physics experiments. The effects of target parameters on heavy-ion experimental results are reviewed. The target fabrication and characterization techniques used to minimize experimental problems during heavy-ion bombardment are described. Topics considered include target thickness and uniformity, target lifetime, target purity, substrate materials, Doppler shift effects, metal preparations, and target preparation methods

Antiproton Target

CERN Multimedia

1980-01-01

Antiproton target used for the AA (antiproton accumulator). The first type of antiproton production target used from 1980 to 1982 comprised a rod of copper 3mm diameter and 120mm long embedded in a graphite cylinder that was itself pressed into a finned aluminium container. This assembly was air-cooled and it was used in conjunction with the Van der Meer magnetic horn. In 1983 Fermilab provided us with lithium lenses to replace the horn with a view to increasing the antiproton yield by about 30%. These lenses needed a much shorter target made of heavy metal - iridium was chosen for this purpose. The 50 mm iridium rod was housed in an extension to the original finned target container so that it could be brought very close to the entrance to the lithium lens. Picture 1 shows this target assembly and Picture 2 shows it mounted together with the lithium lens. These target containers had a short lifetime due to a combination of beam heating and radiation damage. This led to the design of the water-cooled target in...

Target laboratory

International Nuclear Information System (INIS)

Ephraim, D.C.; Pednekar, A.R.

1993-01-01

A target laboratory to make stripper foils for the accelerator and various targets for use in the experiments is set up in the pelletron accelerator facility. The facilities available in the laboratory are: (1) D.C. glow discharge setup, (2) carbon arc set up, and (3) vacuum evaporation set up (resistance heating), electron beam source, rolling mill - all for target preparation. They are described. Centrifugal deposition technique is used for target preparation. (author). 3 figs

75 FR 26796 - Investigations Regarding Certifications of Eligibility To Apply for Worker Adjustment Assistance

Science.gov (United States)

2010-05-12

...) New York, NY 04/19/10 04/16/10 73961 Speidel (Workers) Cranston, RI 04/20/10 04/13/10 73962 Ford Motor... 73969 Cummins, Inc. (Company).... El Paso, TX 04/21/10 04/19/10 73970 CareFusion (Company)....... San.../One-Stop)...... Bothell, WA 04/23/10 04/19/10 73987 Ford Motor Credit (Company) Colorado Springs, CO...

Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing

Science.gov (United States)

Lee, Ciaran M; Cradick, Thomas J; Fine, Eli J; Bao, Gang

2016-01-01

The rapid advancement in targeted genome editing using engineered nucleases such as ZFNs, TALENs, and CRISPR/Cas9 systems has resulted in a suite of powerful methods that allows researchers to target any genomic locus of interest. A complementary set of design tools has been developed to aid researchers with nuclease design, target site selection, and experimental validation. Here, we review the various tools available for target selection in designing engineered nucleases, and for quantifying nuclease activity and specificity, including web-based search tools and experimental methods. We also elucidate challenges in target selection, especially in predicting off-target effects, and discuss future directions in precision genome editing and its applications. PMID:26750397

The target effect: visual memory for unnamed search targets.

Science.gov (United States)

Thomas, Mark D; Williams, Carrick C

2014-01-01

Search targets are typically remembered much better than other objects even when they are viewed for less time. However, targets have two advantages that other objects in search displays do not have: They are identified categorically before the search, and finding them represents the goal of the search task. The current research investigated the contributions of both of these types of information to the long-term visual memory representations of search targets. Participants completed either a predefined search or a unique-object search in which targets were not defined with specific categorical labels before searching. Subsequent memory results indicated that search target memory was better than distractor memory even following ambiguously defined searches and when the distractors were viewed significantly longer. Superior target memory appears to result from a qualitatively different representation from those of distractor objects, indicating that decision processes influence visual memory.

Literature evidence in open targets - a target validation platform.

Science.gov (United States)

Kafkas, Şenay; Dunham, Ian; McEntyre, Johanna

2017-06-06

We present the Europe PMC literature component of Open Targets - a target validation platform that integrates various evidence to aid drug target identification and validation. The component identifies target-disease associations in documents and ranks the documents based on their confidence from the Europe PMC literature database, by using rules utilising expert-provided heuristic information. The confidence score of a given document represents how valuable the document is in the scope of target validation for a given target-disease association by taking into account the credibility of the association based on the properties of the text. The component serves the platform regularly with the up-to-date data since December, 2015. Currently, there are a total number of 1168365 distinct target-disease associations text mined from >26 million PubMed abstracts and >1.2 million Open Access full text articles. Our comparative analyses on the current available evidence data in the platform revealed that 850179 of these associations are exclusively identified by literature mining. This component helps the platform's users by providing the most relevant literature hits for a given target and disease. The text mining evidence along with the other types of evidence can be explored visually through https://www.targetvalidation.org and all the evidence data is available for download in json format from https://www.targetvalidation.org/downloads/data .

VizieR Online Data Catalog: Virgo cluster ETGs: GC and galaxy diffuse light (Li+, 2015)

Science.gov (United States)

Li, B.; Peng, E. W.; Zhang, H.-X.; Blakeslee, J. P.; Cote, P.; Ferrarese, L.; Jordan, A.; Liu, C.; Mei, S.; Puzia, T. H.; Takamiya, M.; Trancho, G.; West, M. J.

2017-09-01

We selected four intermediate-luminosity ETGs from the ACS Virgo Cluster Survey (ACSVCS; Cote et al. 2004, J/ApJS/153/223), a homogeneous Hubble Space Telescope survey of 100 ETGs in the nearby Virgo cluster of galaxies using the Advanced Camera for Surveys (ACS; Ford et al. 1998SPIE.3356..234F). We observed these galaxies with the Gemini Multi-Object Spectrographs (GMOS, Hook et al. 2004PASP..116..425H), twin instruments on the Gemini North and Gemini South telescopes. Our target galaxies have sizes (Re~10-18") that fit well within the GMOS field of view (5.5 arcmin2), providing coverage out to 10-16Re. Each galaxy contained ~50 targetable GCs with VGMOS-South, whereas data for VCC 685 was taken with GMOS-North. (3 data files).

Study of target and non-target interplay in spatial attention task.

Science.gov (United States)

Sweeti; Joshi, Deepak; Panigrahi, B K; Anand, Sneh; Santhosh, Jayasree

2018-02-01

Selective visual attention is the ability to selectively pay attention to the targets while inhibiting the distractors. This paper aims to study the targets and non-targets interplay in spatial attention task while subject attends to the target object present in one visual hemifield and ignores the distractor present in another visual hemifield. This paper performs the averaged evoked response potential (ERP) analysis and time-frequency analysis. ERP analysis agrees to the left hemisphere superiority over late potentials for the targets present in right visual hemifield. Time-frequency analysis performed suggests two parameters i.e. event-related spectral perturbation (ERSP) and inter-trial coherence (ITC). These parameters show the same properties for the target present in either of the visual hemifields but show the difference while comparing the activity corresponding to the targets and non-targets. In this way, this study helps to visualise the difference between targets present in the left and right visual hemifields and, also the targets and non-targets present in the left and right visual hemifields. These results could be utilised to monitor subjects' performance in brain-computer interface (BCI) and neurorehabilitation.

Using the Nova target chamber for high-yield targets

International Nuclear Information System (INIS)

Pitts, J.H.

1987-01-01

The existing 2.2-m-radius Nova aluminum target chamber, coated and lined with boron-seeded carbon shields, is proposed for use with 1000-MJ-yield targets in the next laser facility. The laser beam and diagnostic holes in the target chamber are left open and the desired 10 -2 Torr vacuum is maintained both inside and outside the target chamber; a larger target chamber room is the vacuum barrier to the atmosphere. The hole area available is three times that necessary to maintain a maximum fluence below 12 J/cm 2 on optics placed at a radius of 10 m. Maximum stress in the target chamber wall is 73 MPa, which complies with the intent of the ASME Pressure Vessel Code. However, shock waves passing through the inner carbon shield could cause it to comminute. We propose tests and analyses to ensure that the inner carbon shield survives the environment. 13 refs

Ice targets

International Nuclear Information System (INIS)

Pacheco, C.; Stark, C.; Tanaka, N.; Hodgkins, D.; Barnhart, J.; Kosty, J.

1979-12-01

This report presents a description of ice targets that were constructed for research work at the High Resolution Spectrometer (HRS) and at the Energetic Pion Channel and Spectrometer (EPICS). Reasons for using these ice targets and the instructions for their construction are given. Results of research using ice targets will be published at a later date

SeedVicious: Analysis of microRNA target and near-target sites.

Science.gov (United States)

Marco, Antonio

2018-01-01

Here I describe seedVicious, a versatile microRNA target site prediction software that can be easily fitted into annotation pipelines and run over custom datasets. SeedVicious finds microRNA canonical sites plus other, less efficient, target sites. Among other novel features, seedVicious can compute evolutionary gains/losses of target sites using maximum parsimony, and also detect near-target sites, which have one nucleotide different from a canonical site. Near-target sites are important to study population variation in microRNA regulation. Some analyses suggest that near-target sites may also be functional sites, although there is no conclusive evidence for that, and they may actually be target alleles segregating in a population. SeedVicious does not aim to outperform but to complement existing microRNA prediction tools. For instance, the precision of TargetScan is almost doubled (from 11% to ~20%) when we filter predictions by the distance between target sites using this program. Interestingly, two adjacent canonical target sites are more likely to be present in bona fide target transcripts than pairs of target sites at slightly longer distances. The software is written in Perl and runs on 64-bit Unix computers (Linux and MacOS X). Users with no computing experience can also run the program in a dedicated web-server by uploading custom data, or browse pre-computed predictions. SeedVicious and its associated web-server and database (SeedBank) are distributed under the GPL/GNU license.

The drug target genes show higher evolutionary conservation than non-target genes.

Science.gov (United States)

Lv, Wenhua; Xu, Yongdeng; Guo, Yiying; Yu, Ziqi; Feng, Guanglong; Liu, Panpan; Luan, Meiwei; Zhu, Hongjie; Liu, Guiyou; Zhang, Mingming; Lv, Hongchao; Duan, Lian; Shang, Zhenwei; Li, Jin; Jiang, Yongshuai; Zhang, Ruijie

2016-01-26

Although evidence indicates that drug target genes share some common evolutionary features, there have been few studies analyzing evolutionary features of drug targets from an overall level. Therefore, we conducted an analysis which aimed to investigate the evolutionary characteristics of drug target genes. We compared the evolutionary conservation between human drug target genes and non-target genes by combining both the evolutionary features and network topological properties in human protein-protein interaction network. The evolution rate, conservation score and the percentage of orthologous genes of 21 species were included in our study. Meanwhile, four topological features including the average shortest path length, betweenness centrality, clustering coefficient and degree were considered for comparison analysis. Then we got four results as following: compared with non-drug target genes, 1) drug target genes had lower evolutionary rates; 2) drug target genes had higher conservation scores; 3) drug target genes had higher percentages of orthologous genes and 4) drug target genes had a tighter network structure including higher degrees, betweenness centrality, clustering coefficients and lower average shortest path lengths. These results demonstrate that drug target genes are more evolutionarily conserved than non-drug target genes. We hope that our study will provide valuable information for other researchers who are interested in evolutionary conservation of drug targets.

Oral History Project: Advanced ESL Class, Local 259 U.A.W. 1985-86.

Science.gov (United States)

Colon, Maria, Comp.; And Others

A class project undertaken in an English-as-a-Second-Language class is described and presented. Students participating in the project were union employees in a Manhattan electronics factory, and most were native Spanish speakers. The project's objective was to produce an illustrated book and tapes to document work and union experience in the…

Nova target experiments

International Nuclear Information System (INIS)

Drake, R.P.

1985-11-01

The Nova laser, at the Lawrence Livermore National Laboratory, provides unique opportunities for target experiments. It has unprecedented energy on target and significant flexibility. The paper presented by John Hunt described the capabilities and the status of Nova. This paper discusses plans for future experiments using Nova, and the present status of target experiments. We plan to perform high-quality physics experiments that exploit the unique capabilities of Nova. Because this is our goal, we are fielding an extensive array of well-characterized target diagnostics to measure the emissions from the target. The first section of this paper discusses the basic target diagnostics. We are also taking care to quantify the performance of the laser

Cardiorespiratory fitness attenuates risk for major adverse cardiac events in hyperlipidemic men and women independent of statin therapy: The Henry Ford ExercIse Testing Project.

Science.gov (United States)

Hung, Rupert K; Al-Mallah, Mouaz H; Qadi, Mohamud A; Shaya, Gabriel E; Blumenthal, Roger S; Nasir, Khurram; Brawner, Clinton A; Keteyian, Steven J; Blaha, Michael J

2015-08-01

We sought to evaluate the effect of cardiorespiratory fitness (CRF) in predicting mortality, myocardial infarction (MI), and revascularization in patients with hyperlipidemia after stratification by gender and statin therapy. This retrospective cohort study included 33,204 patients with hyperlipidemia (57 ± 12 years old, 56% men, 25% black) who underwent physician-referred treadmill stress testing at the Henry Ford Health System from 1991 to 2009. Patients were stratified by gender, baseline statin therapy, and estimated metabolic equivalents from stress testing. We computed hazard ratios using Cox regression models after adjusting for demographics, cardiac risk factors, comorbidities, pertinent medications, interaction terms, and indication for stress testing. There were 4,851 deaths, 1,962 MIs, and 2,686 revascularizations over a median follow-up of 10.3 years. In men and women not on statin therapy and men and women on statin therapy, each 1-metabolic equivalent increment in CRF was associated with hazard ratios of 0.86 (95% CI 0.85-0.88), 0.83 (95% CI 0.81-0.85), 0.85 (95% CI 0.83-0.87), and 0.84 (95% CI 0.81-0.87) for mortality; 0.93 (95% CI 0.90-0.96), 0.87 (95% CI 0.83-0.91), 0.89 (95% CI 0.86-0.92), and 0.90 (95% CI 0.86-0.95) for MI; and 0.91 (95% CI 0.88-0.93), 0.87 (95% CI 0.83-0.91), 0.89 (95% CI 0.87-0.92), and 0.90 (95% CI 0.86-0.94) for revascularization, respectively. No significant interactions were observed between CRF and statin therapy (P > .23). Higher CRF attenuated risk for mortality, MI, and revascularization independent of gender and statin therapy in patients with hyperlipidemia. These results reinforce the prognostic value of CRF and support greater promotion of CRF in this patient population. Copyright © 2015 Elsevier Inc. All rights reserved.

NYPA/TH!NK Clean Commute Program Final Report - Inception through December 2004

Energy Technology Data Exchange (ETDEWEB)

James Francfort; Don Karner

2005-11-01

The Clean Commute Program uses TH!NK city electric vehicles from Ford Motor Company’s electric vehicle group, TH!NK Mobility, to demonstrate the feasibility of using electric transportation in urban applications. Suburban New York City railroad commuters use the TH!NK city vehicles to commute from their private residences to railroad stations, where they catch commuter trains into New York City. Electric vehicle charging infrastructure for the TH!NK city vehicles is located at the commuters’ private residences as well as seven train stations. Ford leased at total of 97 TH!NK city electric vehicles to commuters from Westchester, Putnam, Rockland, Queens, Nassau, and Suffolk counties for $199 per month. First Clean Commute Program vehicle deliveries occurred late in 2001, with data collection commencing in February 2002. Through May, 2004, 24 of the lessees have returned their vehicles to Ford and no longer participate in the Clean Commute Program. Reasons given for leaving the Program include relocation out of the Program area, change in employment status, change in commuting status, and, in a few cases, dissatisfaction with the vehicle. Additionally, 13 vehicles were returned to Ford when the lease was completed. In August 2002, Ford announced that it was ceasing production of the TH!NK city and would not extend any TH!NK city leases. Mileage accumulation dropped in the last quarter of the program as vehicle leases were returned to Ford. The impact of the program overall was significant as participants in the Clean Commute Program drove their vehicles over 406,074 miles, avoiding the use of over 18,887 gallons of gasoline. During the active portion of the program, the TH!NK city vehicles were driven an average of between 180 and 230 miles per month. Over 95% of all trips taken with the TH!NK city vehicles replaced trips previously taken in gasoline vehicles. This report covers the period from Program inception through December 2004.

Memory for found targets interferes with subsequent performance in multiple-target visual search.

Science.gov (United States)

Cain, Matthew S; Mitroff, Stephen R

2013-10-01

Multiple-target visual searches--when more than 1 target can appear in a given search display--are commonplace in radiology, airport security screening, and the military. Whereas 1 target is often found accurately, additional targets are more likely to be missed in multiple-target searches. To better understand this decrement in 2nd-target detection, here we examined 2 potential forms of interference that can arise from finding a 1st target: interference from the perceptual salience of the 1st target (a now highly relevant distractor in a known location) and interference from a newly created memory representation for the 1st target. Here, we found that removing found targets from the display or making them salient and easily segregated color singletons improved subsequent search accuracy. However, replacing found targets with random distractor items did not improve subsequent search accuracy. Removing and highlighting found targets likely reduced both a target's visual salience and its memory load, whereas replacing a target removed its visual salience but not its representation in memory. Collectively, the current experiments suggest that the working memory load of a found target has a larger effect on subsequent search accuracy than does its perceptual salience. PsycINFO Database Record (c) 2013 APA, all rights reserved.

Internal Targeting and External Control: Phototriggered Targeting in Nanomedicine.

Science.gov (United States)

Arrue, Lily; Ratjen, Lars

2017-12-07

The photochemical control of structure and reactivity bears great potential for chemistry, biology, and life sciences. A key feature of photochemistry is the spatiotemporal control over secondary events. Well-established applications of photochemistry in medicine are photodynamic therapy (PDT) and photopharmacology (PP). However, although both are highly localizable through the application of light, they lack cell- and tissue-specificity. The combination of nanomaterial-based drug delivery and targeting has the potential to overcome limitations for many established therapy concepts. Even more privileged seems the merger of nanomedicine and cell-specific targeting (internal targeting) controlled by light (external control), as it can potentially be applied to many different areas of medicine and pharmaceutical research, including the aforementioned PDT and PP. In this review a survey of the interface of photochemistry, medicine and targeted drug delivery is given, especially focusing on phototriggered targeting in nanomedicine. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Advanced Gasoline Turbocharged Direction Injection (GTDI) Engine Development

Energy Technology Data Exchange (ETDEWEB)

Wagner, Terrance [Ford Motor Co., Dearborn, MI (United States)

2015-12-31

This program was undertaken in response to US Department of Energy Solicitation DE-FOA-0000079, resulting in a cooperative agreement with Ford and MTU to demonstrate improvement of fuel efficiency in a vehicle equipped with an advanced GTDI engine. Ford Motor Company has invested significantly in GTDI engine technology as a cost effective, high volume, fuel economy solution, marketed globally as EcoBoost technology. Ford envisions additional fuel economy improvement in the medium and long term by further advancing EcoBoost technology. The approach for the project was to engineer a comprehensive suite of gasoline engine systems technologies to achieve the project objectives, and to progressively demonstrate the objectives via concept analysis / computer modeling, single-cylinder and multi-cylinder engine testing on engine dynamometer, and vehicle level testing on chassis rolls.

Radar automatic target recognition (ATR) and non-cooperative target recognition (NCTR)

CERN Document Server

Blacknell, David

2013-01-01

The ability to detect and locate targets by day or night, over wide areas, regardless of weather conditions has long made radar a key sensor in many military and civil applications. However, the ability to automatically and reliably distinguish different targets represents a difficult challenge. Radar Automatic Target Recognition (ATR) and Non-Cooperative Target Recognition (NCTR) captures material presented in the NATO SET-172 lecture series to provide an overview of the state-of-the-art and continuing challenges of radar target recognition. Topics covered include the problem as applied to th

About miRNAs, miRNA seeds, target genes and target pathways.

Science.gov (United States)

Kehl, Tim; Backes, Christina; Kern, Fabian; Fehlmann, Tobias; Ludwig, Nicole; Meese, Eckart; Lenhof, Hans-Peter; Keller, Andreas

2017-12-05

miRNAs are typically repressing gene expression by binding to the 3' UTR, leading to degradation of the mRNA. This process is dominated by the eight-base seed region of the miRNA. Further, miRNAs are known not only to target genes but also to target significant parts of pathways. A logical line of thoughts is: miRNAs with similar (seed) sequence target similar sets of genes and thus similar sets of pathways. By calculating similarity scores for all 3.25 million pairs of 2,550 human miRNAs, we found that this pattern frequently holds, while we also observed exceptions. Respective results were obtained for both, predicted target genes as well as experimentally validated targets. We note that miRNAs target gene set similarity follows a bimodal distribution, pointing at a set of 282 miRNAs that seems to target genes with very high specificity. Further, we discuss miRNAs with different (seed) sequences that nonetheless regulate similar gene sets or pathways. Most intriguingly, we found miRNA pairs that regulate different gene sets but similar pathways such as miR-6886-5p and miR-3529-5p. These are jointly targeting different parts of the MAPK signaling cascade. The main goal of this study is to provide a general overview on the results, to highlight a selection of relevant results on miRNAs, miRNA seeds, target genes and target pathways and to raise awareness for artifacts in respective comparisons. The full set of information that allows to infer detailed results on each miRNA has been included in miRPathDB, the miRNA target pathway database (https://mpd.bioinf.uni-sb.de).

The Consortium Cooperation Versus Competition

Science.gov (United States)

1990-02-01

access to the results is unlimited. By our definition, consortia, strategic alliances , joint ventures, and other commonly used terms all refer to... Strategic Alliances Make Marketing and Manufacturing an International Game Compater-ALded Engineering (Nov 1988): p. 1M24 58tusiness Finance. Vol. 4, No...different cultures and regulations. Ford has solicited the help of Mazda in exporting the Ford Probe and Taurus automobiles to Japan. THE STRUCTURE OF

Integrated Genomic Biomarkers to Identify Aggressive Disease in African Americans with Prostate Cancer

Science.gov (United States)

2017-09-01

Cancer” PRINCIPAL INVESTIGATOR: Dr. Albert Levin CONTRACTING ORGANIZATION: Henry Ford Health System Detroit, MI 48202 REPORT DATE: September 2017 TYPE...hfhs.org 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Henry Ford Health System 1...methylation sites associated with biochemical recurrence in European American men are also associated with risk of recurrence in AA men. In addition , we also

Behavioral Reliability. A Review of Academic Literature and Organizational Programs.

Science.gov (United States)

1984-12-31

Sul & Ml ,n. 1- 1981 ). t’svcholoJical outcomes. Although the impact of life event. on neli ,, .i outcomes ihan also been investigated, much of the...and adjustment in a variety of specific stressful environments (Cooper & Green, 1976; Ford & Spaulding , 1973; Lachar, ...... ’’, Sparks, Larsen...sonality characteristics may play a key role in adjustment and work performance in isolated work environments. Finally, Ford and Spaulding (1973

Target assignment for security officers to K targets (TASK)

International Nuclear Information System (INIS)

Rowland, J.R.; Shelton, K.W.; Stunkel, C.B.

1983-02-01

A probabilistic algorithm is developed to provide an optimal Target Assignment for Security officers to K targets (TASK) using a maximin criterion. Under the assumption of only a limited number (N) of security officers, the TASK computer model determines deployment assignments which maximize the system protection against sabotage by an adversary who may select any link in the system, including the weakest, for the point of attack. Applying the TASK model to a hypothetical nuclear facility containing a nine-level building reveals that aggregate targets covering multiple vital areas should be utilized to reduce the number of possible target assignments to a value equal to or only slightly larger than N. The increased probability that a given aggregate target is covered by one or more security officers offsets the slight decrease in interruption probability due to its occurring earlier in the adversary's path. In brief, the TASK model determines the optimal maximin deployment strategy for limited numbers of security officers and calculates a quantitative measure of the resulting system protection

Deuterium pass through target

International Nuclear Information System (INIS)

Alger, D.L.

1975-01-01

A neutron emitting target is described for use in neutron generating apparatus including a deuteron source and an accelerator vacuum chamber. The target consists of a tritium-containing target layer, a deuteron accumulation layer, and a target support containing passages providing communication between the accumulation layer and portions of the surface of the support exposed to the accelerator vacuum chamber. With this arrangement, deuterons passing through the target layer and implanting in and diffusing through the accumulation layer, diffuse into the communicating passages and are returned to the accelerator vacuum chamber. The invention allows the continuous removal of deuterons from the target in conventional water cooled neutron generating apparatus. Preferably, the target is provided with thin barrier layers to prevent undesirable tritium diffusion out of the target layer, as well as deuteron diffusion into the target layer

Eye tracking a self-moved target with complex hand-target dynamics

Science.gov (United States)

Landelle, Caroline; Montagnini, Anna; Madelain, Laurent

2016-01-01

Previous work has shown that the ability to track with the eye a moving target is substantially improved when the target is self-moved by the subject's hand compared with when being externally moved. Here, we explored a situation in which the mapping between hand movement and target motion was perturbed by simulating an elastic relationship between the hand and target. Our objective was to determine whether the predictive mechanisms driving eye-hand coordination could be updated to accommodate this complex hand-target dynamics. To fully appreciate the behavioral effects of this perturbation, we compared eye tracking performance when self-moving a target with a rigid mapping (simple) and a spring mapping as well as when the subject tracked target trajectories that he/she had previously generated when using the rigid or spring mapping. Concerning the rigid mapping, our results confirmed that smooth pursuit was more accurate when the target was self-moved than externally moved. In contrast, with the spring mapping, eye tracking had initially similar low spatial accuracy (though shorter temporal lag) in the self versus externally moved conditions. However, within ∼5 min of practice, smooth pursuit improved in the self-moved spring condition, up to a level similar to the self-moved rigid condition. Subsequently, when the mapping unexpectedly switched from spring to rigid, the eye initially followed the expected target trajectory and not the real one, thereby suggesting that subjects used an internal representation of the new hand-target dynamics. Overall, these results emphasize the stunning adaptability of smooth pursuit when self-maneuvering objects with complex dynamics. PMID:27466129

Critical Difference and Biological Variation in Biomarkers of Oxidative Stress and Nutritional Status in Athletes.

Directory of Open Access Journals (Sweden)

Nathan A Lewis

Full Text Available The longitudinal monitoring of oxidative stress (OS in athletes may enable the identification of fatigued states and underperformance. The application of OS biomarker monitoring programs in sport are hindered by reliability and repeatability of in-the-field testing tools, the turnaround of results, and the understanding of biological variation (BV. Knowledge of BV and critical difference values (CDV may assist with data interpretation in the individual athlete.We aimed firstly to assess the repeatability of the clinical point of care redox test, Free Oxygen Radical Test (FORT and the Free Oxygen Radical Defence (FORD in trained participants and elite athletes and secondly to calculate the analytical, BV, CDV and index of individuality (II for FORT, FORD, red blood cell glutathione, lutein, α and γ-tocopherol. Part 1: Fifteen elite athletes were sampled in duplicate for calculation of the repeatability of the FORT and FORD tests. Part 2: Twelve well-trained athletes had venous samples drawn every 2 hours from 0800 to 1800 for calculation of BV, CDV, II for FORT, FORD, RBC GSH, lutein, α-tocopherol and γ-tocopherol.Repeatability of the FORT and FORD assay was 3.9% and 3.7% respectively. Biomarker CDV ranged from 12.8% to 37%, with a circadian effect for FORT, α-tocopherol and γ-tocopherol (p<0.01, with all biomarker indices of individuality < 0.8 arbitrary units.We report that the use of the novel redox test in athletes is practical, and the generation of BV and CDV for biomarkers of OS enhances the interpretation of physiologically meaningful changes in individuals above the use of clinical reference ranges alone.

Argus target chamber

International Nuclear Information System (INIS)

Rienecker, F. Jr.; Glaros, S.S.; Kobierecki, M.

1975-01-01

A target chamber for application in the laser fusion program must satisfy some very basic requirements. (1) Provide a vacuum on the order of 10 -6 torr. (2) Support a microscopically small target in a fixed point in space and verify its location within 5 micrometers. (3) Contain an adjustable beam focusing system capable of delivering a number of laser beams onto the target simultaneously, both in time and space. (4) Provide access for diagnostics to evaluate the results of target irradiation. (5) Have flexibility to allow changes in targets, focusing optics and number of beams. The ARGUS laser which is now under construction at LLL will have a target chamber which meets these requirements in a simple economic manner. The chamber and auxiliary equipment are described, with reference to two double beam focusing systems; namely, lenses and ellipsoidal mirrors. Provision is made for future operation with four beams, using ellipsoidal mirrors for two-sided illumination and lens systems for tetragonal and tetrahedral irradiation

Study on aerodynamics characteristics an urban concept car for energy-efficient race

Science.gov (United States)

Ambarita, H.; Siregar, M. R.; Kawai, H.

2018-03-01

"Horas Mesin USU" is a prototype of urban concept vehicle designed by University of Sumatera Utara to participate in the energy-efficient competition. This paper deals with a numerical study on aerodynamic characteristics of the Horas Mesin USU. The numerical analyses are carried out by solving the governing equations using CFD FLUENT commercial code. The turbulent flow is closed using k-epsilon turbulence model. In the results, pathline, velocity vector and pressure distribution are plotted. By using the pressure distributions, drag and lift coefficients are calculated. In order to make a comparison, the aerodynamic characteristics of the present design are compared with commercial city car Ford-Fiesta. The averaged drag coefficients of Horas Mesin USU and Ford-Fiesta are 0.24320 and 0.29598, respectively. On the other hand, the averaged lift coefficients of the Horas Mesin USU and Ford-Fiesta are 0.03192202 and 0.09485621, respectively. This fact suggests that Ford-Fiesta has a better aerodynamic performance in comparison with Horas Mesin USU. The flow field analysis shows that there are many modifications can be proposed to improve the aerodynamic performance of the Horas Mesin USU. It is suggested to perform further analysis to improve the aerodynamic performance of Horas Mesin USU.

Internal bremsstrahlung spectra from 185W and 32P

International Nuclear Information System (INIS)

Babu, R.P.; Murty, K.N.; Murty, V.A.N.

1976-01-01

The internal bremsstrahlung spectra from the β decay of 185 W and 32 P were measured using a NaI(Tl) scintillation spectrometer with a standard geometrical arrangement. After making all the necessary corrections the experimental results are compared with the allowed theory of the Knipp, Uhlenbeck, and Bloch (KUB theory) and also with the Coulomb corrected theories of Lewis, Ford, and Nilsson. In the case of 185 W it is found that from 78 to 200 keV the experimental distribution is in good agreement with the KUB theory whereas beyond 200 keV and below 78 keV the experimental points are far above even the highest Coulomb corrected theoretical distribution of Nilsson. The internal bremsstrahlung from this isotope has not been previously investigated. In the case of 32 P the experimental relative intensity spectrum is compared with the KUB theory and also with the Coulomb corrected theory of Lewis and Ford. Fairly good agreement is obtained from 30 to 200 keV with the KUB theory but in the energy region from 200 to 900 keV, the experimental results deviate positively from both the KUB and Lewis and Ford theories. The experimental excess over the Lewis and Ford theory is 15% on the average

PRICE-LEVEL TARGETING – A VIABLE ALTERNATIVE TO INFLATION TARGETING?

Directory of Open Access Journals (Sweden)

Iulian Vasile Popescu

2012-12-01

Full Text Available The recent financial crisis that has led some central banks reaching the zero lower bound of their interest rate to use unconventional monetary policy instruments, has brought to the forefront theacademic discussions on the shift from inflation targeting (IT to price level targeting. This paper provides a comparative analysis on IT strategy and targeting the price level, assesses the implications and highlights the challenges of an eventual transition to a new monetary policy strategy. Balancing the advantages (mainly better anchored inflation expectations and disadvantages (communication difficulties generated by following a potential price-level targeting strategy and the necessary prerequisites for its functionality (predictive agents, fully familiar with the implications of such a strategy and with complete confidence in themonetary authority has led us to the conclusion that there is no common acceptance that price level targeting strategy might replace the present IT framework.

Wake Shield Target Protection

International Nuclear Information System (INIS)

Valmianski, Emanuil I.; Petzoldt, Ronald W.; Alexander, Neil B.

2003-01-01

The heat flux from both gas convection and chamber radiation on a direct drive target must be limited to avoid target damage from excessive D-T temperature increase. One of the possibilities of protecting the target is a wake shield flying in front of the target. A shield will also reduce drag force on the target, thereby facilitating target tracking and position prediction. A Direct Simulation Monte Carlo (DSMC) code was used to calculate convection heat loads as boundary conditions input into ANSYS thermal calculations. These were used for studying the quality of target protection depending on various shapes of shields, target-shield distance, and protective properties of the shield moving relative to the target. The results show that the shield can reduce the convective heat flux by a factor of 2 to 5 depending on pressure, temperature, and velocity. The protective effect of a shield moving relative to the target is greater than the protective properties of a fixed shield. However, the protective effect of a shield moving under the drag force is not sufficient for bringing the heat load on the target down to the necessary limit. Some other ways of diminishing heat flux using a protective shield are discussed

Internal Bremsstrahlung accompanying beta decay of 90 Y

International Nuclear Information System (INIS)

Elsayed, A.M.A.; Abdelhady, E.E.

1992-01-01

The internal Bremsstrahlung (IB) spectrum associated with the unique first-forbidden β decay of 9 0Y is measured employing the conventional β-stopper technique with a 5 x 5 cm NaI (T 1) scintillation spectrometer in the energy range (50-2000 keV). All the necessary corrections are made. In order to analyze the experimental data, a response matrix having the dimensions of 64 energy bins and 474 channels is constructed.with the help of the detector assembly response matrix, the true IB energy spectrum is obtained by iteratively unfolding the experimental pulse-height spectrum. The experimental results are compared with the corresponding theoretical distributions due to Knipp and Uhlenbeck and Bloch (KUB), lewis and ford (L F), and ford and martin (FM). The results show reasonable agreement with the detour theory of ford and martin.3 fig

Post-targeting strategy for ready-to-use targeted nanodelivery post cargo loading.

Science.gov (United States)

Zhu, J Y; Hu, J J; Zhang, M K; Yu, W Y; Zheng, D W; Wang, X Q; Feng, J; Zhang, X Z

2017-12-14

Based on boronate formation, this study reports a post-targeting methodology capable of readily installing versatile targeting modules onto a cargo-loaded nanoplatform in aqueous mediums. This permits the targeted nanodelivery of broad-spectrum therapeutics (drug/gene) in a ready-to-use manner while overcoming the PEGylation-dilemma that frequently occurs in conventional targeting approaches.

Polygons, Stars, and Clusters; an Investigation of Polygon Displays

Science.gov (United States)

1988-01-01

variables were chosen, nine in each case , to give reasonably complex polygons without being too complex. I have seen no reported studies of the relation...Pont. Catalina C Datsun 210, Toyota Corolla, Dodge Colt, Honda Civic, Mazda GLC, Subaru, Ford Fiesta, Plym. Champ Figure 6. Clusters on the basis of...Merc. Marquis, Pont. Catalina, Pont. Grand Prix C Datsun 210, Toyota Corolla, Dodge Colt, Honda Civic, Mazda GLC, Subaru, Ford Fiesta, Plym. Champ

Impact of the Phase 2 Infantry Advanced Leader Course (ALC)

Science.gov (United States)

2012-07-01

as well as interpersonal skills (Baldwin & Ford, 1988; Baldwin cited in Baldwin & Ford, 1988). In a meta-analysis of 117 studies, Taylor, Russ- Eft ... tapping each of the nine competencies. Correlations were computed among the competencies at the start-/end-of-course and follow-on. These... tapping each of the seven tasks. Intercorrelations among ALC task categories were also calculated at both the start and end of the course as well as

Business Process Re-Engineering Applied to the Air Force Institute of Technology Office of the Registrar, Records Management.

Science.gov (United States)

1994-12-01

and create new ones. An example of this can be seen in the following case study involving the Ford Motor Company (Hammer, 1993:39-41). In the early...executives had an opportunity to observe the operations of Mazda’s accounts payable department. Although Mazda is a smaller organization, the Ford...to reconsider their selection of redesign methodology. Mazda recognized the compelling need to totally restructure the way they did business and

Spreadable media: Creating value and meaning in a networked culture

Directory of Open Access Journals (Sweden)

Moderated by Louisa Stein

2014-09-01

Full Text Available Online Roundtable on Spreadable Media, by Henry Jenkins, Sam Ford, and Joshua Green, with participants Paul Booth, Kristina Busse, Melissa Click, Sam Ford, Henry Jenkins, Xiaochang Li, and Sharon Ross. Section 1 first published as the article "Spreadable Media: Creating Value and Meaning in a Networked Culture", by Louisa Stein, from Cinema Journal Volume 53 Issue 3, pp152-177. Copyright 2014 by The University of Texas Press. All rights reserved.

A peculiar distribution of radial velocities of faint radio-galaxies with 13.0<=msub(corr)<=15.5

International Nuclear Information System (INIS)

Karoji, H.; Nottale, L.; Vigier, J.-P.

1976-01-01

A sample of 41 radio-galaxies with 13.0<=msub(corr)<=15.5 has been analyzed to test the angular redshift anisotropy discovered on Sc I galaxies by Rubin, Rubin and Ford (1973). The sample does not present their anisotropy but contains an even more curious distribution of radial velocities which suggests that the Rubin-Ford effect results from an anomalous redshift of light when it travels through clusters of galaxies. (Auth.)

Inner bremsstrahlung accompanying beta decay of 170Tm

International Nuclear Information System (INIS)

Sanjeeviah, H.; Venkataramaiah, P.; Gundu Rao, K.S.

1980-01-01

The inner bremmsstrahlung (IB) spectrum accompanying beta decay of 170 Tm was measured using magnetic deflection technique. The raw spectrum was unfolded using the procedure of Liden and Starfelt. The unfolded IB spectrum was compared with the theories of Knipp and Uhlenbeck and Bloch; Lewis and Ford. Comparison was made with Ford and Martin theory in order to estimate the contribution of detour transitions to the IB spectrum of 170 Tm. (author)

Targeting an efficient target-to-target interval for P300 speller brain–computer interfaces

Science.gov (United States)

Sellers, Eric W.; Wang, Xingyu

2013-01-01

Longer target-to-target intervals (TTI) produce greater P300 event-related potential amplitude, which can increase brain–computer interface (BCI) classification accuracy and decrease the number of flashes needed for accurate character classification. However, longer TTIs requires more time for each trial, which will decrease the information transfer rate of BCI. In this paper, a P300 BCI using a 7 × 12 matrix explored new flash patterns (16-, 18- and 21-flash pattern) with different TTIs to assess the effects of TTI on P300 BCI performance. The new flash patterns were designed to minimize TTI, decrease repetition blindness, and examine the temporal relationship between each flash of a given stimulus by placing a minimum of one (16-flash pattern), two (18-flash pattern), or three (21-flash pattern) non-target flashes between each target flashes. Online results showed that the 16-flash pattern yielded the lowest classification accuracy among the three patterns. The results also showed that the 18-flash pattern provides a significantly higher information transfer rate (ITR) than the 21-flash pattern; both patterns provide high ITR and high accuracy for all subjects. PMID:22350331

Monitoring production target thickness

International Nuclear Information System (INIS)

Oothoudt, M.A.

1993-01-01

Pion and muon production targets at the Clinton P. Anderson Meson Physics Facility consist of rotating graphite wheels. The previous target thickness monitoring Procedure scanned the target across a reduced intensity beam to determine beam center. The fractional loss in current across the centered target gave a measure of target thickness. This procedure, however, required interruption of beam delivery to experiments and frequently indicated a different fractional loss than at normal beam currents. The new monitoring Procedure compares integrated ups and downs toroid current monitor readings. The current monitors are read once per minute and the integral of readings are logged once per eight-hour shift. Changes in the upstream to downstream fractional difference provide a nonintrusive continuous measurement of target thickness under nominal operational conditions. Target scans are now done only when new targets are installed or when unexplained changes in the current monitor data are observed

Liquid helium target

International Nuclear Information System (INIS)

Fujii, Y.; Kitami, T.; Torikoshi, M.

1984-12-01

A liquid helium target system has been built and used for the experiment on the reaction 4 He(γ, p). The target system has worked satisfactorily; the consumption rate of liquid helium is 360 ml/h and the cryogenic system retains liquid helium for about ten hours. The structure, operation and performance of the target system are reported. (author)

The ISIS target

International Nuclear Information System (INIS)

Carne, A.; Broome, T.A.; Hogston, J.R.; Holding, M.

1989-01-01

This presentation discusses the two target failures that have occurred, gives the understanding of the causes and indicates the steps being taken to alleviate the problems. At the outset of the design it was understood that the target would have a finite lifetime, due to radiation damage effects, exacerbated by mechanical damage due to thermal cycling and fatigue. Estimates of target lifetime at full intensity are about 2 years for radiation damage swelling and about 10E4 gross thermal excursions. The latter number is the one which gives uncertainty in defining the life of the target, since it is dependent on the reliability of the accelerator and quality of the proton beam. The commissioning of an accelerator system and bringing it up to high beam intensities have their own special problems. There must be protection of components against uncontrolled beam loss, which produces thermal damage, prompt radiation and induced activity. Fast beam trips for beam loss protection, or equipment failures, result in quenches from high temperature in the target which get bigger with increasing beam intensity. But the target itself is a difficult device to make, taking about 12 months to manufacture. Further, changing one is a complex and time consuming task, not without its hazards. There is thus something of a balancing act to bring the accelerator towards specification before the target fails due to thermal cycling fatigue. In the early days of ISIS beam loss protection was the dominant consideration and the target was regarded somewhat as a sacrificial lamb to the goddess of machine reliability. 2 refs., 6 figs

Pilots' Attention Distributions Between Chasing a Moving Target and a Stationary Target.

Science.gov (United States)

Li, Wen-Chin; Yu, Chung-San; Braithwaite, Graham; Greaves, Matthew

2016-12-01

Attention plays a central role in cognitive processing; ineffective attention may induce accidents in flight operations. The objective of the current research was to examine military pilots' attention distributions between chasing a moving target and a stationary target. In the current research, 37 mission-ready F-16 pilots participated. Subjects' eye movements were collected by a portable head-mounted eye-tracker during tactical training in a flight simulator. The scenarios of chasing a moving target (air-to-air) and a stationary target (air-to-surface) consist of three operational phases: searching, aiming, and lock-on to the targets. The findings demonstrated significant differences in pilots' percentage of fixation during the searching phase between air-to-air (M = 37.57, SD = 5.72) and air-to-surface (M = 33.54, SD = 4.68). Fixation duration can indicate pilots' sustained attention to the trajectory of a dynamic target during air combat maneuvers. Aiming at the stationary target resulted in larger pupil size (M = 27,105, SD = 6565), reflecting higher cognitive loading than aiming at the dynamic target (M = 23,864, SD = 8762). Pilots' visual behavior is not only closely related to attention distribution, but also significantly associated with task characteristics. Military pilots demonstrated various visual scan patterns for searching and aiming at different types of targets based on the research settings of a flight simulator. The findings will facilitate system designers' understanding of military pilots' cognitive processes during tactical operations. They will assist human-centered interface design to improve pilots' situational awareness. The application of an eye-tracking device integrated with a flight simulator is a feasible and cost-effective intervention to improve the efficiency and safety of tactical training.Li W-C, Yu C-S, Braithwaite G, Greaves M. Pilots' attention distributions between chasing a moving target and a stationary target. Aerosp Med

TargetSpy: a supervised machine learning approach for microRNA target prediction.

Science.gov (United States)

Sturm, Martin; Hackenberg, Michael; Langenberger, David; Frishman, Dmitrij

2010-05-28

Virtually all currently available microRNA target site prediction algorithms require the presence of a (conserved) seed match to the 5' end of the microRNA. Recently however, it has been shown that this requirement might be too stringent, leading to a substantial number of missed target sites. We developed TargetSpy, a novel computational approach for predicting target sites regardless of the presence of a seed match. It is based on machine learning and automatic feature selection using a wide spectrum of compositional, structural, and base pairing features covering current biological knowledge. Our model does not rely on evolutionary conservation, which allows the detection of species-specific interactions and makes TargetSpy suitable for analyzing unconserved genomic sequences.In order to allow for an unbiased comparison of TargetSpy to other methods, we classified all algorithms into three groups: I) no seed match requirement, II) seed match requirement, and III) conserved seed match requirement. TargetSpy predictions for classes II and III are generated by appropriate postfiltering. On a human dataset revealing fold-change in protein production for five selected microRNAs our method shows superior performance in all classes. In Drosophila melanogaster not only our class II and III predictions are on par with other algorithms, but notably the class I (no-seed) predictions are just marginally less accurate. We estimate that TargetSpy predicts between 26 and 112 functional target sites without a seed match per microRNA that are missed by all other currently available algorithms. Only a few algorithms can predict target sites without demanding a seed match and TargetSpy demonstrates a substantial improvement in prediction accuracy in that class. Furthermore, when conservation and the presence of a seed match are required, the performance is comparable with state-of-the-art algorithms. TargetSpy was trained on mouse and performs well in human and drosophila

TargetSpy: a supervised machine learning approach for microRNA target prediction

Directory of Open Access Journals (Sweden)

Langenberger David

2010-05-01

Full Text Available Abstract Background Virtually all currently available microRNA target site prediction algorithms require the presence of a (conserved seed match to the 5' end of the microRNA. Recently however, it has been shown that this requirement might be too stringent, leading to a substantial number of missed target sites. Results We developed TargetSpy, a novel computational approach for predicting target sites regardless of the presence of a seed match. It is based on machine learning and automatic feature selection using a wide spectrum of compositional, structural, and base pairing features covering current biological knowledge. Our model does not rely on evolutionary conservation, which allows the detection of species-specific interactions and makes TargetSpy suitable for analyzing unconserved genomic sequences. In order to allow for an unbiased comparison of TargetSpy to other methods, we classified all algorithms into three groups: I no seed match requirement, II seed match requirement, and III conserved seed match requirement. TargetSpy predictions for classes II and III are generated by appropriate postfiltering. On a human dataset revealing fold-change in protein production for five selected microRNAs our method shows superior performance in all classes. In Drosophila melanogaster not only our class II and III predictions are on par with other algorithms, but notably the class I (no-seed predictions are just marginally less accurate. We estimate that TargetSpy predicts between 26 and 112 functional target sites without a seed match per microRNA that are missed by all other currently available algorithms. Conclusion Only a few algorithms can predict target sites without demanding a seed match and TargetSpy demonstrates a substantial improvement in prediction accuracy in that class. Furthermore, when conservation and the presence of a seed match are required, the performance is comparable with state-of-the-art algorithms. TargetSpy was trained on

TBC2target: A Resource of Predicted Target Genes of Tea Bioactive Compounds

Directory of Open Access Journals (Sweden)

Shihua Zhang

2018-02-01

Full Text Available Tea is one of the most popular non-alcoholic beverages consumed worldwide. Numerous bioactive constituents of tea were confirmed to possess healthy benefits via the mechanisms of regulating gene expressions or protein activities. However, a complete interacting profile between tea bioactive compounds (TBCs and their target genes is lacking, which put an obstacle in the study of healthy function of tea. To fill this gap, we developed a database of target genes of TBCs (TBC2target, http://camellia.ahau.edu.cn/TBC2target based on a pharmacophore mapping approach. In TBC2target, 6,226 interactions between 240 TBCs and 673 target genes were documented. TBC2target contains detailed information about each interacting entry, such as TBC, CAS number, PubChem CID, source of compound (e.g., green, black, compound type, target gene(s of TBC, gene symbol, gene ID, ENSEMBL ID, PDB ID, TBC bioactivity and the reference. Using the TBC-target associations, we constructed a bipartite network and provided users the global network and local sub-network visualization and topological analyses. The entire database is free for online browsing, searching and downloading. In addition, TBC2target provides a BLAST search function to facilitate use of the database. The particular strengths of TBC2target are the inclusion of the comprehensive TBC-target interactions, and the capacity to visualize and analyze the interacting networks, which may help uncovering the beneficial effects of tea on human health as a central resource in tea health community.

TBC2target: A Resource of Predicted Target Genes of Tea Bioactive Compounds.

Science.gov (United States)

Zhang, Shihua; Zhang, Liang; Wang, Yijun; Yang, Jian; Liao, Mingzhi; Bi, Shoudong; Xie, Zhongwen; Ho, Chi-Tang; Wan, Xiaochun

2018-01-01

Tea is one of the most popular non-alcoholic beverages consumed worldwide. Numerous bioactive constituents of tea were confirmed to possess healthy benefits via the mechanisms of regulating gene expressions or protein activities. However, a complete interacting profile between tea bioactive compounds (TBCs) and their target genes is lacking, which put an obstacle in the study of healthy function of tea. To fill this gap, we developed a database of target genes of TBCs (TBC2target, http://camellia.ahau.edu.cn/TBC2target) based on a pharmacophore mapping approach. In TBC2target, 6,226 interactions between 240 TBCs and 673 target genes were documented. TBC2target contains detailed information about each interacting entry, such as TBC, CAS number, PubChem CID, source of compound (e.g., green, black), compound type, target gene(s) of TBC, gene symbol, gene ID, ENSEMBL ID, PDB ID, TBC bioactivity and the reference. Using the TBC-target associations, we constructed a bipartite network and provided users the global network and local sub-network visualization and topological analyses. The entire database is free for online browsing, searching and downloading. In addition, TBC2target provides a BLAST search function to facilitate use of the database. The particular strengths of TBC2target are the inclusion of the comprehensive TBC-target interactions, and the capacity to visualize and analyze the interacting networks, which may help uncovering the beneficial effects of tea on human health as a central resource in tea health community.

PRICE-LEVEL TARGETING – A VIABLE ALTERNATIVE TO INFLATION TARGETING?

OpenAIRE

Iulian Vasile Popescu

2012-01-01

The recent financial crisis that has led some central banks reaching the zero lower bound of their interest rate to use unconventional monetary policy instruments, has brought to the forefront the academic discussions on the shift from inflation targeting (IT) to price level targeting. This paper provides a comparative analysis on IT strategy and targeting the price level, assesses the implications and highlights the challenges of an eventual transition to a new monetary policy strategy. Bala...

Progress in ISOL target-ion source systems

Energy Technology Data Exchange (ETDEWEB)

Koester, U. [Institut Laue Langevin, 6 Rue Jules Horowitz, F-38042 Grenoble Cedex 9 (France); ISOLDE, CERN, CH-1211 Geneve 23 (Switzerland)], E-mail: koester@ill.fr; Arndt, O. [HGF VISTARS and Institut fuer Kernchemie, Johannes-Gutenberg Universitaet Mainz, D-55128 Mainz (Germany); Bouquerel, E.; Fedoseyev, V.N. [ISOLDE, CERN, CH-1211 Geneve 23 (Switzerland); Franberg, H. [ISOLDE, CERN, CH-1211 Geneve 23 (Switzerland); Laboratory for Radio- and Environmental Chemistry, Paul Scherrer Institut, CH-5232 Villigen PSI (Switzerland); Joinet, A. [ISOLDE, CERN, CH-1211 Geneve 23 (Switzerland); Centre d' Etude Spatiale des Rayonnements, 9 Av. du Colonel Roche, F-31028 Toulouse Cedex 4 (France); Jost, C. [HGF VISTARS and Institut fuer Kernchemie, Johannes-Gutenberg Universitaet Mainz, D-55128 Mainz (Germany); Kerkines, I.S.K. [Laboratory of Physical Chemistry, National and Kapodistrian University of Athens, Department of Chemistry, Zografou 157 71, GR (Greece); Cherry L. Emerson Center for Scientific Computation and Department of Chemistry, Emory University, Atlanta, GA 30322 (United States); Kirchner, R. [Gesellschaft fuer Schwerionenforschung, Planckstr. 1, D-64291 Darmstadt (Germany)

2008-10-15

The heart of every ISOL (isotope separation on-line) facility is its target and ion source system. Its efficiency, selectivity and rapidity is decisive for the production of intense and pure ion beams of short-lived isotopes. Recent progress in ISOL target and ion source technology is discussed at the examples of radioactive ion beams of exotic zinc and tin isotopes that were purified by isothermal chromatography and molecular sideband separation respectively. An outlook is given to which other elements these purification methods are applicable.

Progress in ISOL target-ion source systems

International Nuclear Information System (INIS)

Koester, U.; Arndt, O.; Bouquerel, E.; Fedoseyev, V.N.; Franberg, H.; Joinet, A.; Jost, C.; Kerkines, I.S.K.; Kirchner, R.

2008-01-01

The heart of every ISOL (isotope separation on-line) facility is its target and ion source system. Its efficiency, selectivity and rapidity is decisive for the production of intense and pure ion beams of short-lived isotopes. Recent progress in ISOL target and ion source technology is discussed at the examples of radioactive ion beams of exotic zinc and tin isotopes that were purified by isothermal chromatography and molecular sideband separation respectively. An outlook is given to which other elements these purification methods are applicable.

Polarized targets and beams

International Nuclear Information System (INIS)

Meyer, W.

1985-01-01

First the experimental situation of the single-pion photoproduction and the photodisintegration of the deuteron is briefly discussed. Then a description of the Bonn polarization facilities is given. The point of main effort is put on the polarized target which plays a vital role in the program. A facility for photon induced double polarization experiments at ELSA will be presented in section 4. Properties of a tensor polarized deuteron target are discussed in section 5. The development in the field of polarized targets, especially on new target materials, enables a new generation of polarized target experiments with (polarized) electrons. Some comments on the use of a polarized target in combination with electron beams will be discussed in section 6. Electron deuteron scattering from a tensor polarized deuteron target is considered and compared with other experimental possibilities. (orig./HSI)

Targeted Radionuclide Therapy

Directory of Open Access Journals (Sweden)

David Cheng

2011-10-01

Full Text Available Targeted radiotherapy is an evolving and promising modality of cancer treatment. The killing of cancer cells is achieved with the use of biological vectors and appropriate radionuclides. Among the many advantages of this approach are its selectiveness in delivering the radiation to the target, relatively less severe and infrequent side effects, and the possibility of assessing the uptake by the tumor prior to the therapy. Several different radiopharmaceuticals are currently being used by various administration routes and targeting mechanisms. This article aims to briefly review the current status of targeted radiotherapy as well as to outline the advantages and disadvantages of radionuclides used for this purpose.

Targeted Radionuclide Therapy

Energy Technology Data Exchange (ETDEWEB)

Ersahin, Devrim, E-mail: devrimersahin@yahoo.com; Doddamane, Indukala; Cheng, David [Department of Diagnostic Radiology, School of Medicine, Yale University, 333 Cedar St., New Haven, CT 06520 (United States)

2011-10-11

Targeted radiotherapy is an evolving and promising modality of cancer treatment. The killing of cancer cells is achieved with the use of biological vectors and appropriate radionuclides. Among the many advantages of this approach are its selectiveness in delivering the radiation to the target, relatively less severe and infrequent side effects, and the possibility of assessing the uptake by the tumor prior to the therapy. Several different radiopharmaceuticals are currently being used by various administration routes and targeting mechanisms. This article aims to briefly review the current status of targeted radiotherapy as well as to outline the advantages and disadvantages of radionuclides used for this purpose.

Targeted Radionuclide Therapy

International Nuclear Information System (INIS)

Ersahin, Devrim; Doddamane, Indukala; Cheng, David

2011-01-01

Targeted radiotherapy is an evolving and promising modality of cancer treatment. The killing of cancer cells is achieved with the use of biological vectors and appropriate radionuclides. Among the many advantages of this approach are its selectiveness in delivering the radiation to the target, relatively less severe and infrequent side effects, and the possibility of assessing the uptake by the tumor prior to the therapy. Several different radiopharmaceuticals are currently being used by various administration routes and targeting mechanisms. This article aims to briefly review the current status of targeted radiotherapy as well as to outline the advantages and disadvantages of radionuclides used for this purpose

Contractors on the Battlefield: A Case Study of the Airborne Reconnaissance Low (ARL) Life-Cycle Logistics Support Contract - March 2000 Through August 2001

Science.gov (United States)

2001-12-01

military vehicles, so they were forced to go to Heidelberg, Germany, to rent Ford Broncos (equivalent to U.S. Ford Explorers). They were also...several of the technicians had family ties to the area. The unit was relocated to El Paso, Texas, in late 1999. Following the relocation, more than...half of the contractor’s personnel resigned. Several were transferred to South Korea. Many individuals did not want to live in the El Paso area, and

Kayak Club

CERN Multimedia

Kayak Club

2014-01-01

                        Canoë Kayak CERN (CKC)   Le Partenariat entre la concession Ford Pays de Gex du groupe Maurin et le Canoë kayak CERN (CKC), s'est concrétisé le jeudi 12 juin lors de la livraison du Ford transit Custom que la concession met à disposition du club pour favoriser le développement  de ses activités dans le bassin Lémanique,  eau vive sur le bassin d'Etrembières et Chancy , eau plate à Aire-la-Ville et le lac Leman, ou encore le Dragon boat à Divonne les Bains. Pour la remise des clés, Philippe Murgia directeur commercial Ford Pays de Gex, Olivier Barriere président du CKC et Yann Dunant jeune stagiaire a...

NYPA/TH!NK Clean Commute Program Report – Inception Through May 2004

Energy Technology Data Exchange (ETDEWEB)

Don Karner; James Francfort; Randall Solomon

2004-11-01

The Clean Commute Program uses TH!NK city electric vehicles from Ford Motor Company’s electric vehicle group, TH!NK Mobility, to demonstrate the feasibility of using electric vehicles for transportation in urban applications. Suburban New York City railroad commuters use the TH!NK city vehicles to commute from their private residences to railroad stations, where they catch commuter trains into New York City. Electric vehicle charging infrastructure for the TH!NK city vehicles is located at the commuters’ private residences as well as seven train stations. Ford leased 97 TH!NK city electric vehicles to commuters from Westchester, Putnam, Rockland, Queens, Nassau, and Suffolk counties for $199 per month per vehicle. The first Clean Commute Program vehicle deliveries occurred late in 2001, with data collection commencing in February 2002. Through May 2004, 24 of the lessees have returned their vehicles to Ford and no longer participate in the Clean Commute Program. Reasons given for returning the vehicles include relocation out of the Program area, change in employment status, change in commuting status, and, in a few cases, dissatisfaction with the vehicle. Additionally, 13 vehicles have been returned to Ford as their leases have completed. In August 2002, Ford announced that it was ceasing production of the TH!NK city and would not extend any TH!NK city leases. Through May 2004, participants in the Clean Commute Program have driven their vehicles over 370,000 miles, avoiding the use of over 17,000 gallons of gasoline. The TH!NK city vehicles are driven an average of between 180 and 230 miles per month, and over 95% of all trips taken with the TH!NK city vehicles replace trips previously taken in gasoline vehicles. This report covers the period from Program inception through May 2004.

Experimental investigation of the role of rock fabric in gas generation and expulsion during thermal maturation: Anhydrous closed-system pyrolysis of a bitumen-rich Eagle Ford Shale

Science.gov (United States)

Shao, Deyong; Ellis, Geoffrey S.; Li, Yanfang; Zhang, Tongwei

2018-01-01

Gold-tube pyrolysis experiments were conducted on miniature core plugs and powdered rock from a bitumen-rich sample of Eagle Ford Shale to investigate the role of rock fabric in gas generation and expulsion during thermal maturation. The samples were isothermally heated at 130, 300, 310, 333, 367, 400, and 425 °C for 72 h under a confining pressure of 68.0 MPa, corresponding to six levels of induced thermal maturity: pre-oil generation (130 °C/72 h), incipient oil/bitumen generation (300 and 310 °C/72 h), early oil generation (333 °C/72 h), peak oil generation (367 °C/72 h), early oil cracking (400 °C/72 h), and late oil cracking (425 °C/72 h). Experimental results show that gas retention coupled with compositional fractionation occurs in the core plug experiments and varies as a function of thermal maturity. During the incipient oil/bitumen generation stage, yields of methane through pentane (C1–C5) from core plugs are significantly lower than those from rock powder, and gases from core plugs are enriched in methane. However, the differences in C1–C5 gas yield and composition decrease throughout the oil generation stage, and by the oil cracking stage no obvious compositional difference in C1–C5 gases exists. The decrease in the effect of rock fabric on gas yield and composition with increasing maturity is the result of an increase in gas expulsion efficiency. Pyrolysis of rock powder yields 4–16 times more CO2 compared to miniature core plugs, with δ13CCO2 values ranging from −2.9‰ to −0.6‰, likely due to carbonate decomposition accelerated by reactions with organic acids. Furthermore, lower yields of gaseous alkenes and H2 from core plug experiments sugge

Using the Dual-Target Cost to Explore the Nature of Search Target Representations

Science.gov (United States)

Stroud, Michael J.; Menneer, Tamaryn; Cave, Kyle R.; Donnelly, Nick

2012-01-01

Eye movements were monitored to examine search efficiency and infer how color is mentally represented to guide search for multiple targets. Observers located a single color target very efficiently by fixating colors similar to the target. However, simultaneous search for 2 colors produced a dual-target cost. In addition, as the similarity between…

Target size matters: target errors contribute to the generalization of implicit visuomotor learning.

Science.gov (United States)

Reichenthal, Maayan; Avraham, Guy; Karniel, Amir; Shmuelof, Lior

2016-08-01

The process of sensorimotor adaptation is considered to be driven by errors. While sensory prediction errors, defined as the difference between the planned and the actual movement of the cursor, drive implicit learning processes, target errors (e.g., the distance of the cursor from the target) are thought to drive explicit learning mechanisms. This distinction was mainly studied in the context of arm reaching tasks where the position and the size of the target were constant. We hypothesize that in a dynamic reaching environment, where subjects have to hit moving targets and the targets' dynamic characteristics affect task success, implicit processes will benefit from target errors as well. We examine the effect of target errors on learning of an unnoticed perturbation during unconstrained reaching movements. Subjects played a Pong game, in which they had to hit a moving ball by moving a paddle controlled by their hand. During the game, the movement of the paddle was gradually rotated with respect to the hand, reaching a final rotation of 25°. Subjects were assigned to one of two groups: The high-target error group played the Pong with a small ball, and the low-target error group played with a big ball. Before and after the Pong game, subjects performed open-loop reaching movements toward static targets with no visual feedback. While both groups adapted to the rotation, the postrotation reaching movements were directionally biased only in the small-ball group. This result provides evidence that implicit adaptation is sensitive to target errors. Copyright © 2016 the American Physiological Society.

High-efficiency target-ion sources for RIB generation

International Nuclear Information System (INIS)

Alton, G.D.

1993-01-01

A brief review is given of high-efficiency ion sources which have been developed or are under development at ISOL facilities which show particular promise for use at existing, future, or radioactive ion beam (RIB) facilities now under construction. Emphasis will be placed on those sources which have demonstrated high ionization efficiency, species versatility, and operational reliability and which have been carefully designed for safe handling in the high level radioactivity radiation fields incumbent at such facilities. Brief discussions will also be made of the fundamental processes which affect the realizable beam intensities in target-ion sources. Among the sources which will be reviewed will be selected examples of state-of-the-art electron-beam plasma-type ion sources, thermal-ionization, surface-ionization, ECR, and selectively chosen ion source concepts which show promise for radioactive ion beam generation. A few advanced, chemically selective target-ion sources will be described, such as sources based on the use of laser-resonance ionization, which, in principle, offer a more satisfactory solution to isobaric contamination problems than conventional electromagnetic techniques. Particular attention will be given to the sources which have been selected for initial or future use at the Holifield Radioactive Ion Beam Facility now under construction at the Oak Ridge National Laboratory

TargetCompare: A web interface to compare simultaneous miRNAs targets.

Science.gov (United States)

Moreira, Fabiano Cordeiro; Dustan, Bruno; Hamoy, Igor G; Ribeiro-Dos-Santos, André M; Dos Santos, Andrea Ribeiro

2014-01-01

MicroRNAs (miRNAs) are small non-coding nucleotide sequences between 17 and 25 nucleotides in length that primarily function in the regulation of gene expression. A since miRNA has thousand of predict targets in a complex, regulatory cell signaling network. Therefore, it is of interest to study multiple target genes simultaneously. Hence, we describe a web tool (developed using Java programming language and MySQL database server) to analyse multiple targets of pre-selected miRNAs. We cross validated the tool in eight most highly expressed miRNAs in the antrum region of stomach. This helped to identify 43 potential genes that are target of at least six of the referred miRNAs. The developed tool aims to reduce the randomness and increase the chance of selecting strong candidate target genes and miRNAs responsible for playing important roles in the studied tissue. http://lghm.ufpa.br/targetcompare.

Complete fabrication of target experimental chamber and implement initial target diagnostics to be used for the first target experiments in NDCX-1

International Nuclear Information System (INIS)

Bieniosek, F.M.; Bieniosek, F.M.; Dickinson, M.R.; Henestroza, E.; Katayanagi, T.; Jung, J.Y.; Lee, C.W.; Leitner, M.; Ni, P.; Roy, P.; Seidl, P.; Waldron, W.; Welch, D.

2008-01-01

The Heavy Ion Fusion Science Virtual National Laboratory (HIFS-VNL) has completed the fabrication of a new experimental target chamber facility for future Warm Dense Matter (WDM) experiments, and implemented initial target diagnostics to be used for the first target experiments in NDCX-1. The target chamber has been installed on the NDCX-I beamline. This achievement provides to the HIFS-VNL unique and state-of-the-art experimental capabilities in preparation for the planned target heating experiments using intense heavy ion beams

Structured cylindrical targets

International Nuclear Information System (INIS)

Arnold, R.

1986-01-01

A variety of experimental concepts using high-energy heavy-ion beams in cylindrical targets have been studied through numerical simulation. With an accelerator planned for GSl, plasma temperatures of 100 eV can be reached by cylindrical compression, using inhomogeneous hollow-shell targets. Magnetic insulation, using external fields, has been explored as an aid in reaching high core temperatures. Experiments on collision-pumped x-ray laser physics are also discussed. (ii) Two-dimensional PlC code simulations of homogeneous solid targets show hydrodynamic effects not found in previous 1-D calculations. (iii) Preliminary ideas for an experiment on non-equilibrium heavy-ion charge-states using an existing accelerator and a pre-formed plasma target are outlined. (author)

Structured cylindrical targets

International Nuclear Information System (INIS)

Arnold, R.; Lackner-Russo, D.; Meyer-ter-Vehn, J.; Hoffmann, I.

1986-01-01

A variety of experimental concepts using high-energy heavy-ion beams in cylindrical targets have been studied through numerical simulation. With an accelerator planned for GSl, plasma temperatures of 100 eV can be reached by cylindrical compression, using inhomogenous hollow-shell targets. Magnetic insulation, using external fields, has been explored as an aid in reaching high core temperatures. Experiments on collision-pumped x-ray laser physics are also discussed. (ii) Two-dimensional PlC code simulations of homogeneous solid targets show hydrodynamic effects not found in previous l-D calculations. (iii) Preliminary ideas for an experiment on non-equilibrium heavy-ion charge-states using an existing accelerator and a pre-formed plasma target are outlined. (author)

Target Price Accuracy

Directory of Open Access Journals (Sweden)

Alexander G. Kerl

2011-04-01

Full Text Available This study analyzes the accuracy of forecasted target prices within analysts’ reports. We compute a measure for target price forecast accuracy that evaluates the ability of analysts to exactly forecast the ex-ante (unknown 12-month stock price. Furthermore, we determine factors that explain this accuracy. Target price accuracy is negatively related to analyst-specific optimism and stock-specific risk (measured by volatility and price-to-book ratio. However, target price accuracy is positively related to the level of detail of each report, company size and the reputation of the investment bank. The potential conflicts of interests between an analyst and a covered company do not bias forecast accuracy.

TargetRNA: a tool for predicting targets of small RNA action in bacteria

OpenAIRE

Tjaden, Brian

2008-01-01

Many small RNA (sRNA) genes in bacteria act as posttranscriptional regulators of target messenger RNAs. Here, we present TargetRNA, a web tool for predicting mRNA targets of sRNA action in bacteria. TargetRNA takes as input a genomic sequence that may correspond to an sRNA gene. TargetRNA then uses a dynamic programming algorithm to search each annotated message in a specified genome for mRNAs that evince basepair-binding potential to the input sRNA sequence. Based on the calculated basepair-...

Development of distributed target

CERN Document Server

Yu Hai Jun; Li Qin; Zhou Fu Xin; Shi Jin Shui; Ma Bing; Chen Nan; Jing Xiao Bing

2002-01-01

Linear introduction accelerator is expected to generate small diameter X-ray spots with high intensity. The interaction of the electron beam with plasmas generated at the X-ray converter will make the spot on target increase with time and debase the X-ray dose and the imaging resolving power. A distributed target is developed which has about 24 pieces of thin 0.05 mm tantalum films distributed over 1 cm. due to the structure adoption, the distributed target material over a large volume decreases the energy deposition per unit volume and hence reduces the temperature of target surface, then reduces the initial plasma formalizing and its expansion velocity. The comparison and analysis with two kinds of target structures are presented using numerical calculation and experiments, the results show the X-ray dose and normalized angle distribution of the two is basically the same, while the surface of the distributed target is not destroyed like the previous block target

Internal targets for LEAR

International Nuclear Information System (INIS)

Kilian, K.; Gspann, J.; Mohl, D.; Poth, H.

1984-01-01

This chapter considers the use of thin internal targets in conjunction with phase-space cooling at the Low-Energy Antiproton Ring (LEAR). Topics considered include the merits of internal target operation; the most efficient use of antiprotons and of proton synchrotron (PS) protons, highest center-of-mass (c.m.) energy resolution; highest angular resolution and access to extreme angles; the transparent environment for all reaction products; a windowless source and pure targets; highest luminosity and count rates; access to lowest energies with increasing resolution; internal target thickness and vacuum requirements; required cooling performance; and modes of operation. It is demonstrated that an internal target in conjunction with phase-space cooling has the potential of better performance in terms of the economic use of antiprotons and consequently of PS protons; energy resolution; angular resolution; maximum reaction rate capability (statistical precision); efficient parasitic operation; transparency of the target for reaction products; access to low energies; and the ease of polarized target experiments. It is concluded that all p - experiments which need high statistics and high p - flux, such as studies of rare channels or broad, weak resonance structures, would profit from internal targets

TargetMine, an integrated data warehouse for candidate gene prioritisation and target discovery.

Directory of Open Access Journals (Sweden)

Yi-An Chen

Full Text Available Prioritising candidate genes for further experimental characterisation is a non-trivial challenge in drug discovery and biomedical research in general. An integrated approach that combines results from multiple data types is best suited for optimal target selection. We developed TargetMine, a data warehouse for efficient target prioritisation. TargetMine utilises the InterMine framework, with new data models such as protein-DNA interactions integrated in a novel way. It enables complicated searches that are difficult to perform with existing tools and it also offers integration of custom annotations and in-house experimental data. We proposed an objective protocol for target prioritisation using TargetMine and set up a benchmarking procedure to evaluate its performance. The results show that the protocol can identify known disease-associated genes with high precision and coverage. A demonstration version of TargetMine is available at http://targetmine.nibio.go.jp/.

HIRFL–CSR internal cluster target

International Nuclear Information System (INIS)

Shao, Caojie; Lu, Rongchun; Cai, Xiaohong; Yu, Deyang; Ruan, Fangfang; Xue, Yingli; Zhang, Jianming; Torpokov, D.K.; Nikolenko, D.

2013-01-01

Highlights: • An internal cluster target was built and installed at HIRFL–CSR. • The target thickness for H 2 amounts up to 6.6 × 10 12 atoms/cm 2 . • The feasibility and stability of the internal cluster target were verified by on-line experiments. -- Abstract: Since HIRFL–CSR internal cluster target was built, it has played a key role in in-ring experiments at HIRFL–CSR. So far it have been operated with five gas species as targets for scattering experiments, i.e. hydrogen, nitrogen, argon, neon, and krypton. The obtained highest thickness for hydrogen target amounts up to 10 12 atoms/cm 2 , and those of other targets are larger than 10 13 atoms/cm 2 with the background pressure of 10 −11 mbar in CSR. The target thickness can be varied by regulating the nozzle temperature and pressure of the inlet gas. The first online internal target experiment dedicated to investigate radioactive electron capture (REC) process with Xe 54+ ions colliding with the nitrogen target demonstrated the stability and reliability of the internal target system. In addition, hydrogen and krypton were also tested online in recent experiments, which indicate the target system can meet experimental requirements for the thickness of target, pressure in scattering chamber, and long-term stability

TU-PIS-Exhibit Hall-5: Use of the Enterprise-wide Dose Tracking Software Radimetrics In an Academic Medical System

International Nuclear Information System (INIS)

Goode, A.

2015-01-01

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant

TU-PIS-Exhibit Hall-2: How to Move Beyond Dose Monitoring to Imaging Performance Utilization

International Nuclear Information System (INIS)

Valencia, D.

2015-01-01

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant

TU-PIS-Exhibit Hall-3: Simultaneous tracking of patient and real time staff dose to optimize interventional workflow

International Nuclear Information System (INIS)

Boon, S.

2015-01-01

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant

TU-F-BRB-03: Clinical Implementation of MR-Based Motion Management

International Nuclear Information System (INIS)

Glide-Hurst, C.

2015-01-01

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant

TU-F-BRB-02: Motion Artifacts and Suppression in MRI

International Nuclear Information System (INIS)

Zhong, X.

2015-01-01

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant

TU-PIS-Exhibit Hall-1: Tools for Collecting and Analyzing Patient Dose Index Information from Imaging Equipment

International Nuclear Information System (INIS)

Wang, J.

2015-01-01

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant

TU-PIS-Exhibit Hall-4: How to implement a dose monitoring solution in the real world: a technical perspective

International Nuclear Information System (INIS)

Massey, S.

2015-01-01

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant

TU-F-BRB-00: MRI-Based Motion Management for RT

International Nuclear Information System (INIS)

2015-01-01

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant

TU-PIS-Exhibit Hall-4: How to implement a dose monitoring solution in the real world: a technical perspective

Energy Technology Data Exchange (ETDEWEB)

Massey, S. [PACSHealth (United States)

2015-06-15

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant.

TU-PIS-Exhibit Hall-5: Use of the Enterprise-wide Dose Tracking Software Radimetrics In an Academic Medical System

Energy Technology Data Exchange (ETDEWEB)

Goode, A. [Bayer Healthcare (Germany)

2015-06-15

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant.

TU-PIS-Exhibit Hall-1: Tools for Collecting and Analyzing Patient Dose Index Information from Imaging Equipment

Energy Technology Data Exchange (ETDEWEB)

Wang, J. [Rush University Medical Center, Chicago, IL (United States); Stanford University: Introduction (United States)

2015-06-15

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant.

TU-PIS-Exhibit Hall-2: How to Move Beyond Dose Monitoring to Imaging Performance Utilization

Energy Technology Data Exchange (ETDEWEB)

Valencia, D. [Imalogix (United States)

2015-06-15

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant.

TU-F-BRB-03: Clinical Implementation of MR-Based Motion Management

Energy Technology Data Exchange (ETDEWEB)

Glide-Hurst, C. [Henry Ford Health System (United States)

2015-06-15

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant.

TU-F-BRB-00: MRI-Based Motion Management for RT

Energy Technology Data Exchange (ETDEWEB)

NONE

2015-06-15

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant.

TU-F-BRB-01: Resolving and Characterizing Breathing Motion for Radiotherapy with MRI

Energy Technology Data Exchange (ETDEWEB)

Tryggestad, E. [Mayo Clinic (United States)

2015-06-15

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant.

TU-PIS-Exhibit Hall-3: Simultaneous tracking of patient and real time staff dose to optimize interventional workflow

Energy Technology Data Exchange (ETDEWEB)

Boon, S.

2015-06-15

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant.

TU-F-BRB-02: Motion Artifacts and Suppression in MRI

Energy Technology Data Exchange (ETDEWEB)

Zhong, X. [Siemens (Germany)

2015-06-15

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant.

TU-F-BRB-01: Resolving and Characterizing Breathing Motion for Radiotherapy with MRI

International Nuclear Information System (INIS)

Tryggestad, E.

2015-01-01

The current clinical standard of organ respiratory imaging, 4D-CT, is fundamentally limited by poor soft-tissue contrast and imaging dose. These limitations are potential barriers to beneficial “4D” radiotherapy methods which optimize the target and OAR dose-volume considering breathing motion but rely on a robust motion characterization. Conversely, MRI imparts no known radiation risk and has excellent soft-tissue contrast. MRI-based motion management is therefore highly desirable and holds great promise to improve radiotherapy of moving cancers, particularly in the abdomen. Over the past decade, MRI techniques have improved significantly, making MR-based motion management clinically feasible. For example, cine MRI has high temporal resolution up to 10 f/s and has been used to track and/or characterize tumor motion, study correlation between external and internal motions. New MR technologies, such as 4D-MRI and MRI hybrid treatment machines (i.e. MR-linac or MR-Co60), have been recently developed. These technologies can lead to more accurate target volume determination and more precise radiation dose delivery via direct tumor gating or tracking. Despite all these promises, great challenges exist and the achievable clinical benefit of MRI-based tumor motion management has yet to be fully explored, much less realized. In this proposal, we will review novel MR-based motion management methods and technologies, the state-of-the-art concerning MRI development and clinical application and the barriers to more widespread adoption. Learning Objectives: Discuss the need of MR-based motion management for improving patient care in radiotherapy. Understand MR techniques for motion imaging and tumor motion characterization. Understand the current state of the art and future steps for clinical integration. Henry Ford Health System holds research agreements with Philips Healthcare. Research sponsored in part by a Henry Ford Health System Internal Mentored Grant

Vibration Analysis Of Automotive Structures Using Holographic Interferometry

Science.gov (United States)

Brown, G. M.; Wales, R. R.

1983-10-01

Since 1979, Ford Motor Company has been developing holographic interferometry to supplement more conventional test methods to measure vehicle component vibrations. An Apollo PHK-1 Double Pulse Holographic Laser System was employed to visualize a variety of complex vibration modes, primarily on current production and prototype powertrain components. Design improvements to reduce powertrain response to problem excitations have been deter-mined through pulsed laser holography, and have, in several cases, been put into production in Ford vehicles. Whole-field definition of vibration related deflections provide continuity of information missed by accelerometer/modal analysis techniaues. Certain opera-tional problems, common among pulsed ruby holographic lasers, have reauired ongoing hardware and electronics improvements to minimize system downtime. Real-time, time-averaged and stroboscopic C. W. laser holographic techniques are being developed at Ford to complement the double pulse capabilities and provide rapid identification of modal frequencies and nodal lines for analysis of powertrain structures. Methods for mounting and exciting powertrains to minimize rigid body motions are discussed. Work at Ford will continue toward development of C. W. holographic techniques to provide refined test methodology dedicated to noise and vibration diagnostics with particular emphasis on semi-automated methods for quantifying displacement and relative phase using high resolution digitized video and computers. Continued use of refined pulsed and CW laser holographic interferometry for the analysis of complex structure vibrations seems assured.

Differing Levels of Forestry Best Management Practices at Stream Crossing Structures Affect Sediment Delivery and Installation Costs

Directory of Open Access Journals (Sweden)

Brian C. Morris

2016-03-01

Full Text Available Forestry best management practices (BMPs are used to reduce sedimentation from forest stream crossings. Three BMP treatments (BMP−, BMP-std, and BMP+ were applied to three forest road stream crossings (bridge, culvert, and ford. BMP− did not meet existing BMP guidelines, BMP-std met standard recommendations, and BMP+ treatments exceeded recommendations. Following BMP applications, three simulated rainfall intensities (low, medium, and high were applied in order to evaluate sediment delivery from crossing type and BMP level. During rainfall simulation, sediment concentrations (mg/L were collected with automated samplers and discharge (L/s was estimated to calculate total sediment loading. Costs of stream crossings and BMP levels were also quantified. Mean sediment associated with the three stream crossings were 3.38, 1.87, and 0.64 Mg for the BMP−, BMP-std, and BMP+ levels, respectively. Ford, culvert, and bridge crossings produced 13.04, 12.95, and 0.17 Mg of sediment during construction, respectively. BMP enhancement was more critical for sediment control at the culvert and ford crossings than at the bridge. Respective costs for BMP−, BMP-std, and BMP+ levels were $5,368, $5,658, and $5,858 for the bridge; $3,568, $4,166 and $4,595 for the culvert; and $180, $420 and $1,903 for the ford. Costs and sediment values suggest that current standard BMP levels effectively reduce stream sediment while minimizing costs.

New type of metal targets

International Nuclear Information System (INIS)

Bukharov, A.V.; Ankudinov, V.B.; Ogorodnikov, V.P.; Marukhin, Y.A.

2014-01-01

Now the technologies based on interaction of high-intensity beams with substance of a target are being intensively developed. As a target it is possible to use the new type of monodisperse metal targets. The principal advantages of new targets type are: target cooling isn't required; there is no induced activity: the target can be used many times; small dispersion on the speed, the size and interaction points with a beam. The basis of a target is the jet of molten metal, following in the vacuum chamber .Under the influence of the special disturbance superimposed on the liquid jet, the jet disintegrated into identical drops. In the vacuum chamber the drops freeze and form into the solid granules. It is possible to receive monodisperse targets from different metals, alloys and salts (diameter of targets is from 30 .m to 1.5 mm). Dispersion by the sizes and speed is less than 1%. The technique allows to receive not only continuous targets, but also hollow targets with dispersion on thickness of wall within 1...2%.

Heavy water jet target and a beryllium target for production of fast neutrons

International Nuclear Information System (INIS)

Logan, C.M.; Anderson, J.D.; Barschall, H.H.; Davis, J.C.

1975-01-01

A limitation on the neutron flux obtainable from proton or deuteron induced reactions is the heating of the target by the accelerated charged particles. The heat can be removed more easily if the target moves. The possibility of using a rotating Be target and a heavy water jet as a target for bombardment by 35-MeV deuterons was studied. In a thick Be metal target moving at 10 m/sec through such a beam of 1 cm diameter a temperature pulse of about 300 0 C will be produced by the 0.3 MW beam. The Be target should be able to withstand such a temperature pulse. A Be target suitable for 3 MW of power in a 1 cm diameter beam would require internal cooling and a higher velocity. A free jet of heavy water is also a possible target. Laser photographs of water jets in vacuum show small angles of divergence. The effect of heating by a 0.3 MW beam is probably not important because the temperature rise produced by the beam is small compared to the absolute temperature of the unheated jet. (auth)

Just in TIME (Jit): Sebuah Panduan Menuju Keunggulan Kompetitif

OpenAIRE

Johan S, Andi

2008-01-01

The most people think that JIT developing by Toyota Motor about 1970. This system integration product and assembly industry in Detroit by Henry Ford. Ford say that “Waste is the stock of materials in goods in excess of requirement that turns up in high prices and low wages” (Jhonson and Wood, 1996). In 1980, industries in USA and Eropa begin to use JIT and adoption from Jepang. One people say that “zero inventory system, lean production system, synchronous manufacturing, stockless production...

Miscellany

OpenAIRE

Baillet, Françoise; Bazin, Claire; Bonifas, Gilbert; Bouvard, Luc; Bullen, J.-B.; Bury, Laurent; Bury, Laurent; Cachin, Marie-Françoise; Chassagnol, Anne; Clais, Jacqueline; Davie, Neil; Davison-Pégon, Claire; Doussot, Audrey; Dupeyron-Lafay, Françoise; Énaud-Lechien, Isabelle

2015-01-01

Le numéro 73 des Cahiers victoriens et édouardiens rassemble 10 contributions diverses portant sur des sujets variés comme le Cardinal Manning, Emily Brontë, George Eliot, Robert Browning, Whistler, Ford Madox Brown, Arthur Conan Doyle, Laurence Housman, les parodies de dandies au music-hall, et Oscar Wilde. This issue of Cahiers victoriens et édouardiens gathers 10 contributions on subjects as varied as Cardinal Manning, Emily Brontë, George Eliot, Robert Browning, Whistler, Ford Madox Brow...

Christiane's Hair

OpenAIRE

Lévy Véhel , Jacques; Mendivil , Franklin

2013-01-01

Paul R. Halmos - Lester R. Ford Award http://www.maa.org/programs/maa-awards/writing-awards/paul-halmos-lester-ford-awards; International audience; We explore the geometric and measure-theoretic properties of a set built by stacking central Cantor sets with continuously varying scaling factors. By using self-similarity, we are able to describe in a fairly complete way its main features. We show that it is made of an uncountable number of analytic curves, compute the exact areas of the gaps of...

Intensity measurement of automotive headlamps using a photometric vision system

Science.gov (United States)

Patel, Balvant; Cruz, Jose; Perry, David L.; Himebaugh, Frederic G.

1996-01-01

Requirements for automotive head lamp luminous intensity tests are introduced. The rationale for developing a non-goniometric photometric test system is discussed. The design of the Ford photometric vision system (FPVS) is presented, including hardware, software, calibration, and system use. Directional intensity plots and regulatory test results obtained from the system are compared to corresponding results obtained from a Ford goniometric test system. Sources of error for the vision system and goniometer are discussed. Directions for new work are identified.

ATLAS 60’ Fording Study

Science.gov (United States)

1992-03-03

8217orma parta~ do la pieze utilizable inmediatarnente quo se encuentra en ef cubretabloro. arriba . Los distribuidores Caterpillar necesitaii estos n...ER91 1 CBEA.-ET T RE 14 985721 2 P.CLIP l~mm EAR3T190H ALAS ATF 1 SENDER UEEA LG-6PNM 34 842 I WSE2 G372 TURSEASPLU-S IN 35 EARTH7 WAHE

Laser targets: introduction

International Nuclear Information System (INIS)

Rosen, M.D.

1985-01-01

The laser target design group was engaged in three main tasks in 1984: (1) analyzing Novette implosion and hohlraum-scaling data, (2) planning for the first experiments on Nova, and (3) designing laboratory x-ray laser targets and experiments. The Novette implosion and hohlraum scaling data are mostly classified and are therefore not discussed in detail here. The authors achieved average final/initial pusher pr ratios of about 50, some 3 times higher than the value achieved in the best Shiva shots. These pr values imply a fuel compression to 100 times liquid density, although this figure and other aspects of the experiments are subject to further interpretation because of detailed questions of target symmetry and stability. Their main long-term goal for Nova is to produce a so-called hydrodynamically equivalent target (HET) - that is, a target whose hydrodynamic behavior (implosion velocity, convergence ratio, symmetry and stability requirements, etc.) is very much like that of a high-gain target, but one that is scaled down in size to match the energy available from Nova and is too small to achieve enough hot-spot pr to ignite the cold, near-Fermi-degenerate fuel around it. Their goal for Nova's first year is to do experiments that will teach them how to achieve the symmetry and stability conditions required by an HET

A method for comparing impacts with real targets to impacts onto the IAEA unyielding target

International Nuclear Information System (INIS)

Ammerman, D.J.

1991-01-01

The severity of the IAEA accident conditions test requirement (IAEA 1990) of an impact onto an essentially unyielding target from a drop height of 9 meters encompasses a large fraction of all real world impacts. This is true, in part, because of the unyielding nature of the impact target. Impacts onto the unyielding target have severities equivalent to higher velocity impacts onto real targets which are not unyielding. The severity of impacts with yielding targets is decreased by the amount of the impact energy absorbed in damaging the target. In demonstrating the severity of the regulatory impact event it is advantageous to be able to relate this impact onto an essentially unyielding target to impacts with yielding targets

Immunotherapy Targets in Pediatric Cancer

International Nuclear Information System (INIS)

Orentas, Rimas J.; Lee, Daniel W.; Mackall, Crystal

2012-01-01

Immunotherapy for cancer has shown increasing success and there is ample evidence to expect that progress gleaned in immune targeting of adult cancers can be translated to pediatric oncology. This manuscript reviews principles that guide selection of targets for immunotherapy of cancer, emphasizing the similarities and distinctions between oncogene-inhibition targets and immune targets. It follows with a detailed review of molecules expressed by pediatric tumors that are already under study as immune targets or are good candidates for future studies of immune targeting. Distinctions are made between cell surface antigens that can be targeted in an MHC independent manner using antibodies, antibody derivatives, or chimeric antigen receptors versus intracellular antigens which must be targeted with MHC restricted T cell therapies. Among the most advanced immune targets for childhood cancer are CD19 and CD22 on hematologic malignancies, GD2 on solid tumors, and NY-ESO-1 expressed by a majority of synovial sarcomas, but several other molecules reviewed here also have properties which suggest that they too could serve as effective targets for immunotherapy of childhood cancer.

Immunotherapy Targets in Pediatric Cancer

Energy Technology Data Exchange (ETDEWEB)

Orentas, Rimas J.; Lee, Daniel W.; Mackall, Crystal, E-mail: rimas.orentas@nih.gov, E-mail: mackallc@mail.nih.gov [Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD (United States)

2012-01-30

Immunotherapy for cancer has shown increasing success and there is ample evidence to expect that progress gleaned in immune targeting of adult cancers can be translated to pediatric oncology. This manuscript reviews principles that guide selection of targets for immunotherapy of cancer, emphasizing the similarities and distinctions between oncogene-inhibition targets and immune targets. It follows with a detailed review of molecules expressed by pediatric tumors that are already under study as immune targets or are good candidates for future studies of immune targeting. Distinctions are made between cell surface antigens that can be targeted in an MHC independent manner using antibodies, antibody derivatives, or chimeric antigen receptors versus intracellular antigens which must be targeted with MHC restricted T cell therapies. Among the most advanced immune targets for childhood cancer are CD19 and CD22 on hematologic malignancies, GD2 on solid tumors, and NY-ESO-1 expressed by a majority of synovial sarcomas, but several other molecules reviewed here also have properties which suggest that they too could serve as effective targets for immunotherapy of childhood cancer.

Bradycardia During Targeted Temperature Management

DEFF Research Database (Denmark)

Thomsen, Jakob Hartvig; Nielsen, Niklas; Hassager, Christian

2016-01-01

OBJECTIVES: Bradycardia is common during targeted temperature management, likely being a physiologic response to lower body temperature, and has recently been associated with favorable outcome following out-of-hospital cardiac arrest in smaller observational studies. The present study sought...... to confirm this finding in a large multicenter cohort of patients treated with targeted temperature management at 33°C and explore the response to targeted temperature management targeting 36°C. DESIGN: Post hoc analysis of a prospective randomized study. SETTING: Thirty-six ICUs in 10 countries. PATIENTS......: We studied 447 (targeted temperature management = 33°C) and 430 (targeted temperature management = 36°C) comatose out-of-hospital cardiac arrest patients with available heart rate data, randomly assigned in the targeted temperature management trial from 2010 to 2013. INTERVENTIONS: Targeted...

26 CFR 1.338-1 - General principles; status of old target and new target.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 4 2010-04-01 2010-04-01 false General principles; status of old target and new target. 1.338-1 Section 1.338-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... of old target and new target. (a) In general—(1) Deemed transaction. Elections are available under...

26 CFR 1.430(d)-1 - Determination of target normal cost and funding target.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Determination of target normal cost and funding target. 1.430(d)-1 Section 1.430(d)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... of target normal cost and funding target. (a) In general—(1) Overview. This section sets forth rules...

Target support for inertial confinement fusion

International Nuclear Information System (INIS)

Schultz, K.R.

1995-08-01

General Atomics (GA) plays an important industrial support role for the US Inertial Confinement Fusion (ICF) program in the area of target technology. This includes three major activities: target fabrication support, target handling systems development, and target chamber design. The work includes target fabrication for existing ICF experiments, target and target system development for future experiments, and target research and target chamber design for experiments on future machines, such as the National Ignition Facility (NIF)

Target-oriented chaos control

International Nuclear Information System (INIS)

Dattani, Justine; Blake, Jack C.H.; Hilker, Frank M.

2011-01-01

Designing intervention methods to control chaotic behavior in dynamical systems remains a challenging problem, in particular for systems that are difficult to access or to measure. We propose a simple, intuitive technique that modifies the values of the state variables directly toward a certain target. The intervention takes into account the difference to the target value, and is a combination of traditional proportional feedback and constant feedback methods. It proves particularly useful when the target corresponds to the equilibrium of the uncontrolled system, and is available or can be estimated from expert knowledge (e.g. in biology and economy). -- Highlights: → We propose a chaos control method that forces the system to a certain target. → The intervention takes into account the difference to the target value. → It can be seen as a combination of proportional and constant feedback methods. → The method is very robust and highly efficient in the long-term. → It is particularly applicable when suitable target values are known or available.

Combinatorial microRNA target predictions

DEFF Research Database (Denmark)

Krek, Azra; Grün, Dominic; Poy, Matthew N.

2005-01-01

MicroRNAs are small noncoding RNAs that recognize and bind to partially complementary sites in the 3' untranslated regions of target genes in animals and, by unknown mechanisms, regulate protein production of the target transcript1, 2, 3. Different combinations of microRNAs are expressed...... in different cell types and may coordinately regulate cell-specific target genes. Here, we present PicTar, a computational method for identifying common targets of microRNAs. Statistical tests using genome-wide alignments of eight vertebrate genomes, PicTar's ability to specifically recover published micro......RNA targets, and experimental validation of seven predicted targets suggest that PicTar has an excellent success rate in predicting targets for single microRNAs and for combinations of microRNAs. We find that vertebrate microRNAs target, on average, roughly 200 transcripts each. Furthermore, our results...

The effect of target and non-target similarity on neural classification performance: A boost from confidence

Directory of Open Access Journals (Sweden)

Amar R Marathe

2015-08-01

Full Text Available Brain computer interaction (BCI technologies have proven effective in utilizing single-trial classification algorithms to detect target images in rapid serial visualization presentation tasks. While many factors contribute to the accuracy of these algorithms, a critical aspect that is often overlooked concerns the feature similarity between target and non-target images. In most real-world environments there are likely to be many shared features between targets and non-targets resulting in similar neural activity between the two classes. It is unknown how current neural-based target classification algorithms perform when qualitatively similar target and non-target images are presented. This study address this question by comparing behavioral and neural classification performance across two conditions: first, when targets were the only infrequent stimulus presented amongst frequent background distracters; and second when targets were presented together with infrequent non-targets containing similar visual features to the targets. The resulting findings show that behavior is slower and less accurate when targets are presented together with similar non-targets; moreover, single-trial classification yielded high levels of misclassification when infrequent non-targets are included. Furthermore, we present an approach to mitigate the image misclassification. We use confidence measures to assess the quality of single-trial classification, and demonstrate that a system in which low confidence trials are reclassified through a secondary process can result in improved performance.

Optimization of in-target yields for RIB production: Part 1: direct targets

International Nuclear Information System (INIS)

Chabod, S.; Thiolliere, N.; David, J.Ch.; Dore, D.; Ene, D.; Rapp, B.; Ridikas, D.; Chabod, S.; Blideanu, V.

2008-03-01

In the framework of the EURISOL-DS project and within Task-11, we have performed in-target yield calculations for different configurations of thick direct targets. The target materials tested are Al 2 O 3 , SiC, Pb(molten), Ta and UC 3 . The target was irradiated with protons of 0.5, 1.0, 1.5 and 2.0 GeV. The production rates have been computed using the MCNPX transport/generation code, coupled with the CINDER-90 evolution program. The yield distributions as a function of charge number Z and mass number A have been evaluated. Their production rates have been optimized for 11 selected elements (Li, Be, Ne, Mg, Ar, Ni, Ga, Kr, Hg, Sn and Fr) and 23 of their isotopes of interest. Finally, the isotopic distributions for each of these 11 elements have been optimized in terms of the target material, its geometry, and incident proton energy

Targeted radionuclide therapy

African Journals Online (AJOL)

target for which a speci c treatment/drug is intended (Fig. 1). eranostics .... Using an anti-CD20 antibody as a delivery device to target the follicular ... systems combine diagnostic imaging (Ga-68-DOTATATE PET/CT) .... Intra-articular injected ...

Changing paradigm from one target one ligand towards multi target directed ligand design for key drug targets of Alzheimer disease: An important role of Insilco methods in multi target directed ligands design.

Science.gov (United States)

Kumar, Akhil; Tiwari, Ashish; Sharma, Ashok

2018-03-15

Alzheimer disease (AD) is now considered as a multifactorial neurodegenerative disorder and rapidly increasing to an alarming situation and causing higher death rate. One target one ligand hypothesis is not able to provide complete solution of AD due to multifactorial nature of disease and one target one drug seems to fail to provide better treatment against AD. Moreover, current available treatments are limited and most of the upcoming treatments under clinical trials are based on modulating single target. So the current AD drug discovery research shifting towards new approach for better solution that simultaneously modulate more than one targets in the neurodegenerative cascade. This can be achieved by network pharmacology, multi-modal therapies, multifaceted, and/or the more recently proposed term "multi-targeted designed drugs. Drug discovery project is tedious, costly and long term project. Moreover, multi target AD drug discovery added extra challenges such as good binding affinity of ligands for multiple targets, optimal ADME/T properties, no/less off target side effect and crossing of the blood brain barrier. These hurdles may be addressed by insilico methods for efficient solution in less time and cost as computational methods successfully applied to single target drug discovery project. Here we are summarizing some of the most prominent and computationally explored single target against AD and further we discussed successful example of dual or multiple inhibitors for same targets. Moreover we focused on ligand and structure based computational approach to design MTDL against AD. However is not an easy task to balance dual activity in a single molecule but computational approach such as virtual screening docking, QSAR, simulation and free energy are useful in future MTDLs drug discovery alone or in combination with fragment based method. However, rational and logical implementations of computational drug designing methods are capable of assisting AD drug

Komunikační strategie vybrané firmy

OpenAIRE

Andrlová, Kateřina

2015-01-01

This Bachelor thesis is dedicated on communication strategy of company Ford MotoTrade VM and its goal is an evaluation of this strategy. In the introduction to the theoretical part I occupy with marketing, its definition and brief history. The separate sub-chapter is devoted to marketing mix as the key issue of this work. At the end of first chapter SWOT analysis is described. The practical part is then focused on the company Ford MotoTrade VM itself, mainly focused on the description of her ...

Environmental Assessment: Disposition of Chiefs’ Circle Residential Structures

Science.gov (United States)

2012-04-27

five structures ranged from Page 4 of 5  $200,000 (with bricks removed) to $500,000 (with bricks intact). Mike Ford, CEO of NewTown Macon, echoed Mr...feasibility 25-Jul-08 and practicality of moving the Chief’s Circle duplexes Mike Ford NewTown Macon 23-Jul-08 478-722-9909 President of NewTown Macon...Daniel.Chavira@ Gave a tour of Chiefs’ Circle huntcompanies.com Not interested in using the houses Bob Sharples RAFB 26-Oct-10 robert.sharples

Energy deposition in a thin copper target downstream and off-axis of a proton-radiography target

International Nuclear Information System (INIS)

Greene, G.A.; Finfrock, C.C.; Snead, C.L.; Hanson, A.L.; Murray, M.M.

2002-01-01

A series of proton energy-deposition experiments was conducted to measure the energy deposited in a copper target located downstream and off-axis of a high-energy proton-radiography target. The proton/target interactions involved low-intensity bunches of protons at 24 GeV/c onto a spherical target consisting of concentric shells of tungsten and copper. The energy-deposition target was placed at five locations downstream of the proton-radiography target, off-axis of the primary beam transport, and was either unshielded or shielded by 5 or 10 cm of lead. Maximum temperature rises measured in the energy-deposition target due to single bunches of 5x10 10 protons on the proton-radiography target were approximately 20 mK per bunch. The data indicated that the scattered radiation was concentrated close to the primary transport axis of the beam line. The energy deposited in the energy-deposition target was reduced by moving the target radially away from the primary transport axis. Placing lead shielding in front of the target further reduced the energy deposition. The measured temperature rises of the energy-deposition target were empirically correlated with the distance from the source, the number of protons incident on the proton-radiography target, the thickness of the lead shielding, and the angle of the energy-deposition target off-axis of the beam line from the proton-radiography target. The correlation of the experimental data that was developed provides a starting point for the evaluation of the shielding requirements for devices downstream of proton-radiography targets such as superconducting magnets

TargetNet: a web service for predicting potential drug-target interaction profiling via multi-target SAR models

Science.gov (United States)

Yao, Zhi-Jiang; Dong, Jie; Che, Yu-Jing; Zhu, Min-Feng; Wen, Ming; Wang, Ning-Ning; Wang, Shan; Lu, Ai-Ping; Cao, Dong-Sheng

2016-05-01

Drug-target interactions (DTIs) are central to current drug discovery processes and public health fields. Analyzing the DTI profiling of the drugs helps to infer drug indications, adverse drug reactions, drug-drug interactions, and drug mode of actions. Therefore, it is of high importance to reliably and fast predict DTI profiling of the drugs on a genome-scale level. Here, we develop the TargetNet server, which can make real-time DTI predictions based only on molecular structures, following the spirit of multi-target SAR methodology. Naïve Bayes models together with various molecular fingerprints were employed to construct prediction models. Ensemble learning from these fingerprints was also provided to improve the prediction ability. When the user submits a molecule, the server will predict the activity of the user's molecule across 623 human proteins by the established high quality SAR model, thus generating a DTI profiling that can be used as a feature vector of chemicals for wide applications. The 623 SAR models related to 623 human proteins were strictly evaluated and validated by several model validation strategies, resulting in the AUC scores of 75-100 %. We applied the generated DTI profiling to successfully predict potential targets, toxicity classification, drug-drug interactions, and drug mode of action, which sufficiently demonstrated the wide application value of the potential DTI profiling. The TargetNet webserver is designed based on the Django framework in Python, and is freely accessible at http://targetnet.scbdd.com.

TargetNet: a web service for predicting potential drug-target interaction profiling via multi-target SAR models.

Science.gov (United States)

Yao, Zhi-Jiang; Dong, Jie; Che, Yu-Jing; Zhu, Min-Feng; Wen, Ming; Wang, Ning-Ning; Wang, Shan; Lu, Ai-Ping; Cao, Dong-Sheng

2016-05-01

Drug-target interactions (DTIs) are central to current drug discovery processes and public health fields. Analyzing the DTI profiling of the drugs helps to infer drug indications, adverse drug reactions, drug-drug interactions, and drug mode of actions. Therefore, it is of high importance to reliably and fast predict DTI profiling of the drugs on a genome-scale level. Here, we develop the TargetNet server, which can make real-time DTI predictions based only on molecular structures, following the spirit of multi-target SAR methodology. Naïve Bayes models together with various molecular fingerprints were employed to construct prediction models. Ensemble learning from these fingerprints was also provided to improve the prediction ability. When the user submits a molecule, the server will predict the activity of the user's molecule across 623 human proteins by the established high quality SAR model, thus generating a DTI profiling that can be used as a feature vector of chemicals for wide applications. The 623 SAR models related to 623 human proteins were strictly evaluated and validated by several model validation strategies, resulting in the AUC scores of 75-100 %. We applied the generated DTI profiling to successfully predict potential targets, toxicity classification, drug-drug interactions, and drug mode of action, which sufficiently demonstrated the wide application value of the potential DTI profiling. The TargetNet webserver is designed based on the Django framework in Python, and is freely accessible at http://targetnet.scbdd.com .

Strategic Targeted Advertising

NARCIS (Netherlands)

A. Galeotti; J.L. Moraga-Gonzalez (José Luis)

2003-01-01

textabstractWe present a strategic game of pricing and targeted-advertising. Firms can simultaneously target price advertisements to different groups of customers, or to the entire market. Pure strategy equilibria do not exist and thus market segmentation cannot occur surely. Equilibria exhibit

Charged particle fusion targets

International Nuclear Information System (INIS)

Bangerter, R.O.; Meeker, D.J.

1977-01-01

The power, voltage, energy and other requirements of electron and ion beam fusion targets are reviewed. Single shell, multiple shell and magnetically insulated target designs are discussed. Questions of stability are also considered. In particular, it is shown that ion beam targets are stabilized by an energy spread in the ion beam

Graphite targets at LAMPF

International Nuclear Information System (INIS)

Brown, R.D.; Grisham, D.L.

1983-01-01

Rotating polycrystalline and stationary pyrolytic graphite target designs for the LAMPF experimental area are described. Examples of finite element calculations of temperatures and stresses are presented. Some results of a metallographic investigation of irradiated pyrolytic graphite target plates are included, together with a brief description of high temperature bearings for the rotating targets

A blow-in windowless gas target

International Nuclear Information System (INIS)

Sagara, K.; Motoshima, A.; Fujita, T.; Akiyoshi, H.; Nishimori, N.

1996-01-01

A new-type windowless gas target has been developed to realize a dense target with a low gas flow rate. The target is similar to the conventional differentially pumped windowless gas target except that the target gas is blown into the target region from both the side holes of the beam entrance and exit. Due to the gas-confining action caused by the blown-in gas, the target thickness is about twice increased and the target density sharply falls in the holes. Most of the target gas is at rest and the density is uniform. The gas flow rate is the same as that of the conventional target and is about an order of magnitude lower than that of the dense gas-jet target. (orig.)

Simulations of effusion from ISOL target/ion source systems

International Nuclear Information System (INIS)

Mustapha, B.; Nolen, J.A.

2004-01-01

Monte Carlo simulations of the low- and high-conductivity Target/Ion Source systems used at Oak Ridge National Laboratory for effusion measurements are performed. Comparisons with the corresponding experimental data for the different geometries are presented and discussed. Independent checks of the simulation using data for simple geometries and using the conductance approach well known in vacuum technology are performed. A simulation-based comparison between the low- and high-conductivity systems is also presented

Inflation targeting and core inflation

OpenAIRE

Julie Smith

2005-01-01

This paper examines the interaction of core inflation and inflation targeting as a monetary policy regime. Interest in core inflation has grown because of inflation targeting. Core inflation is defined in numerous ways giving rise to many potential measures; this paper defines core inflation as the best forecaster of inflation. A cross-country study finds before the start of inflation targeting, but not after, core inflation differs between non-inflation targeters and inflation targeters. Thr...

An ISOLDE target unit

CERN Multimedia

Maximilien Brice

2002-01-01

A good dozen different targets are available for ISOLDE, made of different materials and equipped with different kinds of ion-sources, according to the needs of the experiments. Each separator (GPS: general purpose; HRS: high resolution) has its own target. Because of the high radiation levels, robots effect the target changes, about 80 times per year. In the standard unit shown in picture _01, the target is the cylindrical object in the front. It contains uranium-carbide kept at a temperature of 2200 deg C, necessary for the isotopes to be able to escape. At either end, one sees the heater current leads, carrying 700 A. The Booster beam, some 3E13 protons per pulse, enters the target from left. The evaporated isotope atoms enter a hot-plasma ion source (the black object behind the target). The whole unit sits at 60 kV potential (pulsed in synchronism with the arrival of the Booster beam) which accelerates the ions (away from the viewer) towards one of the 2 separators.

STANFORD: Internal targets

Energy Technology Data Exchange (ETDEWEB)

Riordan, Michael

1989-05-15

Of burgeoning interest to many nuclear and particle physicists is a storage ring technique for fixed target experiments. It hinges on the use of gas-jet targets, shooting a narrow stream of atoms through a circulating beam of electrons or protons. Pioneered at CERN and the Soviet Novosibirsk Laboratory, more such 'internal targets' are being built or contemplated for storage rings in Europe, the Soviet Union, and the United States. From 9-12 January, physicists from around the world met at the Stanford Linear Accelerator Center (SLAC) to discuss prospects and problems in this expanding field.

Burglar Target Selection

Science.gov (United States)

Townsley, Michael; Bernasco, Wim; Ruiter, Stijn; Johnson, Shane D.; White, Gentry; Baum, Scott

2015-01-01

Objectives: This study builds on research undertaken by Bernasco and Nieuwbeerta and explores the generalizability of a theoretically derived offender target selection model in three cross-national study regions. Methods: Taking a discrete spatial choice approach, we estimate the impact of both environment- and offender-level factors on residential burglary placement in the Netherlands, the United Kingdom, and Australia. Combining cleared burglary data from all study regions in a single statistical model, we make statistical comparisons between environments. Results: In all three study regions, the likelihood an offender selects an area for burglary is positively influenced by proximity to their home, the proportion of easily accessible targets, and the total number of targets available. Furthermore, in two of the three study regions, juvenile offenders under the legal driving age are significantly more influenced by target proximity than adult offenders. Post hoc tests indicate the magnitudes of these impacts vary significantly between study regions. Conclusions: While burglary target selection strategies are consistent with opportunity-based explanations of offending, the impact of environmental context is significant. As such, the approach undertaken in combining observations from multiple study regions may aid criminology scholars in assessing the generalizability of observed findings across multiple environments. PMID:25866418

Targeted Nanotechnology for Cancer Imaging

Science.gov (United States)

Toy, Randall; Bauer, Lisa; Hoimes, Christopher; Ghaghada, Ketan B.; Karathanasis, Efstathios

2014-01-01

Targeted nanoparticle imaging agents provide many benefits and new opportunities to facilitate accurate diagnosis of cancer and significantly impact patient outcome. Due to the highly engineerable nature of nanotechnology, targeted nanoparticles exhibit significant advantages including increased contrast sensitivity, binding avidity and targeting specificity. Considering the various nanoparticle designs and their adjustable ability to target a specific site and generate detectable signals, nanoparticles can be optimally designed in terms of biophysical interactions (i.e., intravascular and interstitial transport) and biochemical interactions (i.e., targeting avidity towards cancer-related biomarkers) for site-specific detection of very distinct microenvironments. This review seeks to illustrate that the design of a nanoparticle dictates its in vivo journey and targeting of hard-to-reach cancer sites, facilitating early and accurate diagnosis and interrogation of the most aggressive forms of cancer. We will report various targeted nanoparticles for cancer imaging using X-ray computed tomography, ultrasound, magnetic resonance imaging, nuclear imaging and optical imaging. Finally, to realize the full potential of targeted nanotechnology for cancer imaging, we will describe the challenges and opportunities for the clinical translation and widespread adaptation of targeted nanoparticles imaging agents. PMID:25116445

High or Low Target Prevalence Increases the Dual-Target Cost in Visual Search

Science.gov (United States)

Menneer, Tamaryn; Donnelly, Nick; Godwin, Hayward J.; Cave, Kyle R.

2010-01-01

Previous studies have demonstrated a dual-target cost in visual search. In the current study, the relationship between search for one and search for two targets was investigated to examine the effects of target prevalence and practice. Color-shape conjunction stimuli were used with response time, accuracy and signal detection measures. Performance…

On the configuration of an active target for a fixed-target B experiment at SSC energies

International Nuclear Information System (INIS)

Dukes, E.C.

1993-01-01

The optimal configuration of target and silicon microvertex detector for fixed-target B experiments has yet to be determined. For fixed-target charm experiments the usual setup consists of a series of inert target foils - typically a few millimeters thick and separated by a few centimeters - immediately followed by a silicon microvertex detector. Because of the larger boost at the SSC, the efficacy of using active target foils - tightly packed silicon microstrip detectors - has been considered by at least one group: the SFT collaboration. It is hoped that with an active target the tracks of charged B's themselves can be measured, improving charged B reconstruction efficiencies. The author examines two issues concerning silicon active targets for fixed-target experiments at the SSC: (1) the effect on the acceptance of the requirement that the B decay vertices occur outside of the target foils, and (2) the ability of an active target to directly track charged B's

Target-Searching on Percolation

International Nuclear Information System (INIS)

Yang Shijie

2005-01-01

We study target-searching processes on a percolation, on which a hunter tracks a target by smelling odors it emits. The odor intensity is supposed to be inversely proportional to the distance it propagates. The Monte Carlo simulation is performed on a 2-dimensional bond-percolation above the threshold. Having no idea of the location of the target, the hunter determines its moves only by random attempts in each direction. For lager percolation connectivity p ∼> 0.90, it reveals a scaling law for the searching time versus the distance to the position of the target. The scaling exponent is dependent on the sensitivity of the hunter. For smaller p, the scaling law is broken and the probability of finding out the target significantly reduces. The hunter seems trapped in the cluster of the percolation and can hardly reach the goal.

HomoTarget: a new algorithm for prediction of microRNA targets in Homo sapiens.

Science.gov (United States)

Ahmadi, Hamed; Ahmadi, Ali; Azimzadeh-Jamalkandi, Sadegh; Shoorehdeli, Mahdi Aliyari; Salehzadeh-Yazdi, Ali; Bidkhori, Gholamreza; Masoudi-Nejad, Ali

2013-02-01

MiRNAs play an essential role in the networks of gene regulation by inhibiting the translation of target mRNAs. Several computational approaches have been proposed for the prediction of miRNA target-genes. Reports reveal a large fraction of under-predicted or falsely predicted target genes. Thus, there is an imperative need to develop a computational method by which the target mRNAs of existing miRNAs can be correctly identified. In this study, combined pattern recognition neural network (PRNN) and principle component analysis (PCA) architecture has been proposed in order to model the complicated relationship between miRNAs and their target mRNAs in humans. The results of several types of intelligent classifiers and our proposed model were compared, showing that our algorithm outperformed them with higher sensitivity and specificity. Using the recent release of the mirBase database to find potential targets of miRNAs, this model incorporated twelve structural, thermodynamic and positional features of miRNA:mRNA binding sites to select target candidates. Copyright © 2012 Elsevier Inc. All rights reserved.

Search for Two Categories of Target Produces Fewer Fixations to Target-Color Items

Science.gov (United States)

Menneer, Tamaryn; Stroud, Michael J.; Cave, Kyle R.; Li, Xingshan; Godwin, Hayward J.; Liversedge, Simon P.; Donnelly, Nick

2012-01-01

Searching simultaneously for metal threats (guns and knives) and improvised explosive devices (IEDs) in X-ray images is less effective than 2 independent single-target searches, 1 for metal threats and 1 for IEDs. The goals of this study were to (a) replicate this dual-target cost for categorical targets and to determine whether the cost remains…

Characterization of oil and gas reservoirs and recovery technology deployment on Texas State Lands

Energy Technology Data Exchange (ETDEWEB)

Tyler, R.; Major, R.P.; Holtz, M.H. [Univ. of Texas, Austin, TX (United States)] [and others

1997-08-01

Texas State Lands oil and gas resources are estimated at 1.6 BSTB of remaining mobile oil, 2.1 BSTB, or residual oil, and nearly 10 Tcf of remaining gas. An integrated, detailed geologic and engineering characterization of Texas State Lands has created quantitative descriptions of the oil and gas reservoirs, resulting in delineation of untapped, bypassed compartments and zones of remaining oil and gas. On Texas State Lands, the knowledge gained from such interpretative, quantitative reservoir descriptions has been the basis for designing optimized recovery strategies, including well deepening, recompletions, workovers, targeted infill drilling, injection profile modification, and waterflood optimization. The State of Texas Advanced Resource Recovery program is currently evaluating oil and gas fields along the Gulf Coast (South Copano Bay and Umbrella Point fields) and in the Permian Basin (Keystone East, Ozona, Geraldine Ford and Ford West fields). The program is grounded in advanced reservoir characterization techniques that define the residence of unrecovered oil and gas remaining in select State Land reservoirs. Integral to the program is collaboration with operators in order to deploy advanced reservoir exploitation and management plans. These plans are made on the basis of a thorough understanding of internal reservoir architecture and its controls on remaining oil and gas distribution. Continued accurate, detailed Texas State Lands reservoir description and characterization will ensure deployment of the most current and economically viable recovery technologies and strategies available.

Properties of Protein Drug Target Classes

Science.gov (United States)

Bull, Simon C.; Doig, Andrew J.

2015-01-01

Accurate identification of drug targets is a crucial part of any drug development program. We mined the human proteome to discover properties of proteins that may be important in determining their suitability for pharmaceutical modulation. Data was gathered concerning each protein’s sequence, post-translational modifications, secondary structure, germline variants, expression profile and drug target status. The data was then analysed to determine features for which the target and non-target proteins had significantly different values. This analysis was repeated for subsets of the proteome consisting of all G-protein coupled receptors, ion channels, kinases and proteases, as well as proteins that are implicated in cancer. Machine learning was used to quantify the proteins in each dataset in terms of their potential to serve as a drug target. This was accomplished by first inducing a random forest that could distinguish between its targets and non-targets, and then using the random forest to quantify the drug target likeness of the non-targets. The properties that can best differentiate targets from non-targets were primarily those that are directly related to a protein’s sequence (e.g. secondary structure). Germline variants, expression levels and interactions between proteins had minimal discriminative power. Overall, the best indicators of drug target likeness were found to be the proteins’ hydrophobicities, in vivo half-lives, propensity for being membrane bound and the fraction of non-polar amino acids in their sequences. In terms of predicting potential targets, datasets of proteases, ion channels and cancer proteins were able to induce random forests that were highly capable of distinguishing between targets and non-targets. The non-target proteins predicted to be targets by these random forests comprise the set of the most suitable potential future drug targets, and should therefore be prioritised when building a drug development programme. PMID

Liquid hydrogen and deuterium targets

International Nuclear Information System (INIS)

Bougon, M.; Marquet, M.; Prugne, P.

1961-01-01

A description is given of 1) Atmospheric pressure target: liquid hydrogen, 400 mm thickness; thermal insulation: styrofoam; the hydrogen vapors are used to improve the target cooling; Mylar windows. 2) Vacuum target: 12 liter content: hydrogen or deuterium; liquid thickness 400 mm; thermal insulation is afforded by a vacuum vessel and a liquid nitrogen shield. Recovery and liquefaction of deuterium vapors are managed in the vacuum vessel which holds the target. The target emptying system is designed for operating in a few minutes. (author) [fr

76 FR 34953 - Funding Opportunity Title: Risk Management Education in Targeted States (Targeted States Program...

Science.gov (United States)

2011-06-15

... Availability C. Location and Target Audience D. Maximum Award E. Project Period F. Description of Agreement..., 2011. C. Location and Target Audience The RMA Regional Offices that service the Targeted States are... marketing systems to pursue new markets. D. Purpose The purpose of the Targeted States Program is to provide...

40 CFR 80.60 - Test fleet requirements for exhaust emission testing.

Science.gov (United States)

2010-07-01

... Multi 3W+OX Air EGR 4 GM. 9 TBI 3W+OX Air EGR 7 Chrysler. 10 Multi 3W Air EGR 5 Toyota. 11 Multi 3W No Air EGR 1 Ford. 12 Multi 3W No Air No EGR 2 Chrysler. 13 Carb 3W+OX Air EGR 9 Toyota. 14 TBI 3W No Air EGR 3 Ford. 15 Multi 3W+OX Air EGR 4 GM. 16 Multi 3W No Air EGR 1 Toyota. 17 Multi 3W No Air No EGR 2...

Paranoia på Film

DEFF Research Database (Denmark)

Pedersen, Peter Ole

Filmbog med hovedfokus på temaet overvågning i thriller og science fiction-genren. Gennem omfattende analyser af Francis Ford Coppolas The Conversation (1974), David Finchers Panic Room (2002), George Lucas THX 1138 (1971) og Steven Spielbergs Minority Report (2002) gives kritisk bud på populærfi......Filmbog med hovedfokus på temaet overvågning i thriller og science fiction-genren. Gennem omfattende analyser af Francis Ford Coppolas The Conversation (1974), David Finchers Panic Room (2002), George Lucas THX 1138 (1971) og Steven Spielbergs Minority Report (2002) gives kritisk bud på...

TARGET Research Goals

Science.gov (United States)

TARGET researchers use various sequencing and array-based methods to examine the genomes, transcriptomes, and for some diseases epigenomes of select childhood cancers. This “multi-omic” approach generates a comprehensive profile of molecular alterations for each cancer type. Alterations are changes in DNA or RNA, such as rearrangements in chromosome structure or variations in gene expression, respectively. Through computational analyses and assays to validate biological function, TARGET researchers predict which alterations disrupt the function of a gene or pathway and promote cancer growth, progression, and/or survival. Researchers identify candidate therapeutic targets and/or prognostic markers from the cancer-associated alterations.

Modelling Recycling Targets

DEFF Research Database (Denmark)

hill, amanda; Leinikka Dall, Ole; Andersen, Frits Møller

2014-01-01

% for household waste, and sets an ambitious goal of a 50% recycling rate by 2020. This study integrates the recycling target into the FRIDA model to project how much waste and from which streams should be diverted from incineration to recycling in order to achieve the target. Furthermore, it discusses how...

Targeting the tumor microenvironment

Energy Technology Data Exchange (ETDEWEB)

Kenny, P.A.; Lee, G.Y.; Bissell, M.J.

2006-11-07

Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma. As the details of this dialogue emerge, new therapeutic targets have been proposed. The FDA has already approved drugs targeting microenvironmental components such as VEGF and aromatase and many more agents are in the pipeline. In this article, we describe some of the 'druggable' targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions.

Targeting and Persuasive Advertising

OpenAIRE

Egli, Alain (Autor/in)

2015-01-01

Firms face a prisoner's dilemma when advertising in a competitive environment. In a Hotelling framework with persuasive advertisingfirms counteract this prisoner's dilemma with targeting. The firms even solve the prisoner's problem if targeted advertising is effective enough. Advertising turns from wasteful competition into profits. This is in contrast to wasteful competition as argument for regulations. A further result is maximum advertising differentiation: thefirms target their advertisin...

Target preparation

International Nuclear Information System (INIS)

Hinn, G.M.

1984-01-01

A few of the more interesting of the 210 targets prepared in the Laboratory last year are listed. In addition the author continues to use powdered silver mixed with /sup 9,10/BeO to produce sources for accelerator radio dating of Alaskan and South Polar snow. Currently, he is trying to increase production by multiple sample processing. Also the author routinely makes 3 μg/cm 2 cracked slacked carbon stripper foils and is continuing research with some degree of success in making enriched 28 Si targets starting with the oxide

Preparation of thin nuclear targets

International Nuclear Information System (INIS)

Muggleton, A.H.F.

1979-03-01

Thin film backings, sources and targets are needed for many applications in low energy nuclear physics and nuclear chemistry experiments. A survey of techniques used in the preparation of nuclear targets is first briefly discussed. These are classified as chemical, mechanical and physical preparations. Vacuum evaporation, being the most generally used technique, is discussed in detail. It is highly desirable to monitor the film thickness and control the deposition rate during evaporation and to measure the final target thickness after deposition has concluded. The relative merits of various thickness measuring techniques are described. Stages in the fabrication and mounting of self-supporting foils are described in detail, with emphasis given to the preparation of thin self-supporting carbon foils used as target backings and stripper foils. Various target backings, and the merits of the more generally used release agents are described in detail. The preparations of more difficult elemental targets are discussed, and a comprehensive list of the common targets is presented

Controlled Hydrogen Fleet and Infrastructure Demonstration Project

Energy Technology Data Exchange (ETDEWEB)

Dr. Scott Staley

2010-03-31

This program was undertaken in response to the US Department of Energy Solicitation DE-PS30-03GO93010, resulting in this Cooperative Agreement with the Ford Motor Company and BP to demonstrate and evaluate hydrogen fuel cell vehicles and required fueling infrastructure. Ford initially placed 18 hydrogen fuel cell vehicles (FCV) in three geographic regions of the US (Sacramento, CA; Orlando, FL; and southeast Michigan). Subsequently, 8 advanced technology vehicles were developed and evaluated by the Ford engineering team in Michigan. BP is Ford's principal partner and co-applicant on this project and provided the hydrogen infrastructure to support the fuel cell vehicles. BP ultimately provided three new fueling stations. The Ford-BP program consists of two overlapping phases. The deliverables of this project, combined with those of other industry consortia, are to be used to provide critical input to hydrogen economy commercialization decisions by 2015. The program's goal is to support industry efforts of the US President's Hydrogen Fuel Initiative in developing a path to a hydrogen economy. This program was designed to seek complete systems solutions to address hydrogen infrastructure and vehicle development, and possible synergies between hydrogen fuel electricity generation and transportation applications. This project, in support of that national goal, was designed to gain real world experience with Hydrogen powered Fuel Cell Vehicles (H2FCV) 'on the road' used in everyday activities, and further, to begin the development of the required supporting H2 infrastructure. Implementation of a new hydrogen vehicle technology is, as expected, complex because of the need for parallel introduction of a viable, available fuel delivery system and sufficient numbers of vehicles to buy fuel to justify expansion of the fueling infrastructure. Viability of the fuel structure means widespread, affordable hydrogen which can return a reasonable profit to

Electron beam fusion targets

International Nuclear Information System (INIS)

Clauser, M.J.; Sweeney, M.A.

1975-01-01

R The behavior of the DT filled gold shells when irradiated by a variety of pulse shapes was studied. In these pulses the power (and beam current) was varied, but the voltage was kept constant at 1 MeV. In general the performance of the target, for a given peak power, was not significantly affected by the pulse shape. Pulses with rise times of up to half the implosion time do not significantly degrade the target performance. The use of the ''optimal pulse'' of laser fusion with a fixed peak power does not appear to improve the performance of these targets. The main function of the ''optimal pulse'' is to produce a large rho r of the target during the thermonuclear burn. In e-beam targets a total rho r of 5--10 g/cm 2 can be obtained without pulse shaping; the problem here is one of achieving high enough temperatures to ignite the DT. (U.S.)

Seedling root targets

Science.gov (United States)

Diane L. Haase

2011-01-01

Roots are critical to seedling performance after outplanting. Although root quality is not as quick and simple to measure as shoot quality, target root characteristics should be included in any seedling quality assessment program. This paper provides a brief review of root characteristics most commonly targeted for operational seedling production. These are: root mass...

Nuclear Security: Target Analysis-rev

Energy Technology Data Exchange (ETDEWEB)

Singh, Surinder Paul [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gibbs, Philip W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bultz, Garl A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2014-03-01

The objectives of this presentation are to understand target identification, including roll-up and protracted theft; evaluate target identification in the SNRI; recognize the target characteristics and consequence levels; and understand graded safeguards.

Stanford polarized atomic beam target

International Nuclear Information System (INIS)

Mavis, D.G.; Dunham, J.S.; Hugg, J.W.; Glavish, H.F.

1976-01-01

A polarized atomic beam source was used to produce an atomic hydrogen beam which was in turn used as a polarized proton target. A target density of 2 x 10'' atoms/cm 3 and a target polarization of 0.37 without the use of rf transitions were measured. These measurements indicate that a number of experiments are currently feasible with a variety of polarized target beams

Setting reference targets

International Nuclear Information System (INIS)

Ruland, R.E.

1997-04-01

Reference Targets are used to represent virtual quantities like the magnetic axis of a magnet or the definition of a coordinate system. To explain the function of reference targets in the sequence of the alignment process, this paper will first briefly discuss the geometry of the trajectory design space and of the surveying space, then continue with an overview of a typical alignment process. This is followed by a discussion on magnet fiducialization. While the magnetic measurement methods to determine the magnetic centerline are only listed (they will be discussed in detail in a subsequent talk), emphasis is given to the optical/mechanical methods and to the task of transferring the centerline position to reference targets

Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling.

Science.gov (United States)

Vlot, Anna H C; de Witte, Wilhelmus E A; Danhof, Meindert; van der Graaf, Piet H; van Westen, Gerard J P; de Lange, Elizabeth C M

2017-12-04

Selectivity is an important attribute of effective and safe drugs, and prediction of in vivo target and tissue selectivity would likely improve drug development success rates. However, a lack of understanding of the underlying (pharmacological) mechanisms and availability of directly applicable predictive methods complicates the prediction of selectivity. We explore the value of combining physiologically based pharmacokinetic (PBPK) modeling with quantitative structure-activity relationship (QSAR) modeling to predict the influence of the target dissociation constant (K D ) and the target dissociation rate constant on target and tissue selectivity. The K D values of CB1 ligands in the ChEMBL database are predicted by QSAR random forest (RF) modeling for the CB1 receptor and known off-targets (TRPV1, mGlu5, 5-HT1a). Of these CB1 ligands, rimonabant, CP-55940, and Δ 8 -tetrahydrocanabinol, one of the active ingredients of cannabis, were selected for simulations of target occupancy for CB1, TRPV1, mGlu5, and 5-HT1a in three brain regions, to illustrate the principles of the combined PBPK-QSAR modeling. Our combined PBPK and target binding modeling demonstrated that the optimal values of the K D and k off for target and tissue selectivity were dependent on target concentration and tissue distribution kinetics. Interestingly, if the target concentration is high and the perfusion of the target site is low, the optimal K D value is often not the lowest K D value, suggesting that optimization towards high drug-target affinity can decrease the benefit-risk ratio. The presented integrative structure-pharmacokinetic-pharmacodynamic modeling provides an improved understanding of tissue and target selectivity.

Impacts of transgenic poplar-cotton agro-ecosystems upon target pests and non-target insects under field conditions.

Science.gov (United States)

Zhang, D J; Liu, J X; Lu, Z Y; Li, C L; Comada, E; Yang, M S

2015-07-27

Poplar-cotton agro-ecosystems are the main agricultural planting modes of cotton fields in China. With increasing acres devoted to transgenic insect-resistant poplar and transgenic insect-resistant cotton, studies examining the effects of transgenic plants on target and non-target insects become increasingly important. We systematically surveyed populations of both target pests and non-target insects for 4 different combinations of poplar-cotton eco-systems over 3 years. Transgenic Bt cotton strongly resisted the target insects Fall webworm moth [Hyphantria cunea (Drury)], Sylepta derogata Fabrieius, and American bollworm (Heliothis armigera), but no clear impact on non-target insect cotton aphids (Aphis gossypii). Importantly, intercrops containing transgenic Pb29 poplar significantly increased the inhibitory effects of Bt cotton on Fall webworm moth in ecosystem IV. Highly resistant Pb29 poplar reduced populations of the target pests Grnsonoma minutara Hubner and non-target insect poplar leaf aphid (Chaitophorus po-pulialbae), while Fall webworm moth populations were unaffected. We determined the effects of Bt toxin from transgenic poplar and cotton on target and non-target pests in different ecosystems of cotton-poplar intercrops and identified the synergistic effects of such combinations toward both target and non-target insects.

Online manual movement adjustments in response to target position changes and apparent target motion

NARCIS (Netherlands)

Oostwoud Wijdenes, L.; Brenner, E.; Smeets, J.B.J.

2014-01-01

This study set out to determine whether the fastest online hand movement corrections are only responses to changing judgments of the targets' position or whether they are also influenced by the apparent target motion. Introducing a gap between when a target disappears and when it reappears at a new

The ISOLDE target robots

CERN Multimedia

Maximilein Brice

2002-01-01

ISOLDE targets need to be changed frequently, around 80 times per year. The high radiation levels do not permit this to be done by human hands and the target changes are effected by 2 industrial robots (picture _01). On the left, in the distance, the front-end of the GPS (General Purpose Separator) is seen, while the HRS (High Resolution Separator) is at the right. Also seen are the doors to the irradiated-target storage.

Deuterium high pressure target

International Nuclear Information System (INIS)

Perevozchikov, V.V.; Yukhimchuk, A.A.; Vinogradov, Yu.I.

2001-01-01

The design of the deuterium high-pressure target is presented. The target having volume of 76 cm 3 serves to provide the experimental research of muon catalyzed fusion reactions in ultra-pure deuterium in the temperature range 80-800 K under pressures of up to 150 MPa. The operation of the main systems of the target is described: generation and purification of deuterium gas, refrigeration, heating, evacuation, automated control system and data collection system

Techniques for preparing isotopic targets

International Nuclear Information System (INIS)

Xu Guoji; Guan Shouren; Luo Xinghua; Sun Shuhua

1987-12-01

The techniques of making isotopic targets for nuclear physics experiments are introduced. Vacuum evaporation, electroplating, centrifugal precipitation, rolling and focused heavy-ion beam sputtering used to prepare various isotopic targets at IAE are described. Reduction-distillation with active metals and electrolytic reduction for converting isotope oxides to metals are mentioned. The stripping processes of producing self-supporting isotopic targets are summarized. The store methods of metallic targets are given

Community composition of target vs. non-target fungi in fungicide treated wheat

DEFF Research Database (Denmark)

Knorr, Kamilla; Jørgensen, Lise Nistrup; Justesen, Annemarie Fejer

2012-01-01

disease in wheat and within the last decade, new aggressive strains of yellow rust has caused severe epidemics that lead to substantial yield losses. This study explored the community composition of target versus non-target fungi in yellow rust infected wheat as affected by treatment timing and dose......Fungicide treatments are common control strategies used to manage fungal pathogens in agricultural fields, however, effects of treatments on the composition of total fungal communities, including non-target fungi, in the phyllosphere is not well known. Yellow rust (Puccinia striiformis) is a common...

Feature-based RNN target recognition

Science.gov (United States)

Bakircioglu, Hakan; Gelenbe, Erol

1998-09-01

Detection and recognition of target signatures in sensory data obtained by synthetic aperture radar (SAR), forward- looking infrared, or laser radar, have received considerable attention in the literature. In this paper, we propose a feature based target classification methodology to detect and classify targets in cluttered SAR images, that makes use of selective signature data from sensory data, together with a neural network technique which uses a set of trained networks based on the Random Neural Network (RNN) model (Gelenbe 89, 90, 91, 93) which is trained to act as a matched filter. We propose and investigate radial features of target shapes that are invariant to rotation, translation, and scale, to characterize target and clutter signatures. These features are then used to train a set of learning RNNs which can be used to detect targets within clutter with high accuracy, and to classify the targets or man-made objects from natural clutter. Experimental data from SAR imagery is used to illustrate and validate the proposed method, and to calculate Receiver Operating Characteristics which illustrate the performance of the proposed algorithm.

Canoe-Kayak Club

CERN Multimedia

Canoe-Kayak Club

2017-01-01

Avec le printemps le Canoë Kayak CERN lance le coup d’envoi de la saison 2017. Cette nouvelle saison a commencé de la plus belle des manières, par la cérémonie de la remise des clés du nouveau camion, mercredi 22 mars, au garage du Lac à Segny. Ce camion est le fruit d’un partenariat entre le club et le garage FORD pays de Gex à Segny, dans le but de promouvoir le Canoë kayak, le dragon boat et le stand up paddle dans le bassin Genevois, mais également de promouvoir l’image de la concession FORD dans le Pays de Gex. Ce Partenariat est né au printemps 2014 avec un premier camion qui vient d’être renouvelé pour une durée de 30mois. Il faut noté également que depuis la fin de l’année 2016 Ford Pays de Gex est membre d’Interfon  proposant des remises sur certains...

Inertial-confinement-fusion targets

International Nuclear Information System (INIS)

Hendricks, C.D.

1982-01-01

Much of the research in laser fusion has been done using simple ball on-stalk targets filled with a deuterium-tritium mixture. The targets operated in the exploding pusher mode in which the laser energy was delivered in a very short time (approx. 100 ps or less) and was absorbed by the glass wall of the target. The high energy density in the glass literally exploded the shell with the inward moving glass compressing the DT fuel to high temperatures and moderate densities. Temperatures achieved were high enough to produce DT reactions and accompanying thermonuclear neutrons and alpha particles. The primary criteria imposed on the target builders were: (1) wall thickness, (2) sphere diameter, and (3) fuel in the sphere

Solid Polarized Targets and Applications

International Nuclear Information System (INIS)

Crabb, D. G.

2008-01-01

Examples are given of dynamically polarized targets in use today and how the subsystems have changed to meet the needs of todays experiments. Particular emphasis is placed on target materials such as ammonia and lithium deuteride. Recent polarization studies of irradiated materials such as butanol, deuterated butanol, polyethylene, and deuterated polyethylene are presented. The operation of two non-DNP target systems as well as applications of traditional DNP targets are briefly discussed

Nova target diagnostics control system

International Nuclear Information System (INIS)

Severyn, J.R.

1985-01-01

During the past year the Nova target diagnostics control system was finished and put in service. The diagnostics loft constructed to the north of the target room provides the environmental conditions required to collect reliable target diagnostic data. These improvements include equipment cooling and isolation of the power source with strict control of instrumentation grounds to eliminate data corruption due to electromagnetic pulses from the laser power-conditioning system or from target implosion effects

The effect of target and non-target similarity on neural classification performance: A boost from confidence

OpenAIRE

Amar R Marathe; Anthony J Ries; Vernon J Lawhern; Vernon J Lawhern; Brent J Lance; Jonathan eTouryan; Kaleb eMcDowell; Hubert eCecotti

2015-01-01

Brain computer interaction (BCI) technologies have proven effective in utilizing single-trial classification algorithms to detect target images in rapid serial visualization presentation tasks. While many factors contribute to the accuracy of these algorithms, a critical aspect that is often overlooked concerns the feature similarity between target and non-target images. In most real-world environments there are likely to be many shared features between targets and non-targets resulting in si...

The effect of target and non-target similarity on neural classification performance: a boost from confidence

OpenAIRE

Marathe, Amar R.; Ries, Anthony J.; Lawhern, Vernon J.; Lance, Brent J.; Touryan, Jonathan; McDowell, Kaleb; Cecotti, Hubert

2015-01-01

Brain computer interaction (BCI) technologies have proven effective in utilizing single-trial classification algorithms to detect target images in rapid serial visualization presentation tasks. While many factors contribute to the accuracy of these algorithms, a critical aspect that is often overlooked concerns the feature similarity between target and non-target images. In most real-world environments there are likely to be many shared features between targets and non-targets resulting in si...

Targeted Learning

CERN Document Server

van der Laan, Mark J

2011-01-01

The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the targe

The CNGS target

CERN Multimedia

Patrice Loïez

2005-01-01

The CERN Neutrinos to Gran Sasso (CNGS) target ‘magazine’ of five target units. Each unit contains a series of 10-cm long graphite rods distributed over a length of 2 m. It is designed to maximize the number of secondary particles produced and hence the number of neutrinos. One unit is used at a time to prevent over heating.

Fusion target design

International Nuclear Information System (INIS)

Bangerter, R.O.

1978-01-01

Most detailed fusion target design is done by numerical simulation using large computers. Although numerical simulation is briefly discussed, this lecture deals primarily with the way in which basic physical arguments, driver technology considerations and economical power production requirements are used to guide and augment the simulations. Physics topics discussed include target energetics, preheat, stability and symmetry. A specific design example is discussed

Beam heating of target foils

International Nuclear Information System (INIS)

Corwin, W.C.

1975-01-01

A target rotator, built to reduce the effects of beam spot heating, is fully adjustable, holds three targets, is chamber independent, and takes up limited space. The expected temperature rise in the target is calculated from the Stefan--Boltzmann law

Emotionally conditioning the target-speech voice enhances recognition of the target speech under "cocktail-party" listening conditions.

Science.gov (United States)

Lu, Lingxi; Bao, Xiaohan; Chen, Jing; Qu, Tianshu; Wu, Xihong; Li, Liang

2018-05-01

Under a noisy "cocktail-party" listening condition with multiple people talking, listeners can use various perceptual/cognitive unmasking cues to improve recognition of the target speech against informational speech-on-speech masking. One potential unmasking cue is the emotion expressed in a speech voice, by means of certain acoustical features. However, it was unclear whether emotionally conditioning a target-speech voice that has none of the typical acoustical features of emotions (i.e., an emotionally neutral voice) can be used by listeners for enhancing target-speech recognition under speech-on-speech masking conditions. In this study we examined the recognition of target speech against a two-talker speech masker both before and after the emotionally neutral target voice was paired with a loud female screaming sound that has a marked negative emotional valence. The results showed that recognition of the target speech (especially the first keyword in a target sentence) was significantly improved by emotionally conditioning the target speaker's voice. Moreover, the emotional unmasking effect was independent of the unmasking effect of the perceived spatial separation between the target speech and the masker. Also, (skin conductance) electrodermal responses became stronger after emotional learning when the target speech and masker were perceptually co-located, suggesting an increase of listening efforts when the target speech was informationally masked. These results indicate that emotionally conditioning the target speaker's voice does not change the acoustical parameters of the target-speech stimuli, but the emotionally conditioned vocal features can be used as cues for unmasking target speech.

Influence of lateral target size on hot electron production and electromagnetic pulse emission from laser-irradiated metallic targets

International Nuclear Information System (INIS)

Chen Ziyu; Li Jianfeng; Yu Yong; Li Xiaoya; Peng Qixian; Zhu Wenjun; Wang Jiaxiang

2012-01-01

The influences of lateral target size on hot electron production and electromagnetic pulse emission from laser interaction with metallic targets have been investigated. Particle-in-cell simulations at high laser intensities show that the yield of hot electrons tends to increase with lateral target size, because the larger surface area reduces the electrostatic field on the target, owing to its expansion along the target surface. At lower laser intensities and longer time scales, experimental data characterizing electromagnetic pulse emission as a function of lateral target size also show target-size effects. Charge separation and a larger target tending to have a lower target potential have both been observed. The increase in radiation strength and downshift in radiation frequency with increasing lateral target size can be interpreted using a simple model of the electrical capacity of the target.

Influence of lateral target size on hot electron production and electromagnetic pulse emission from laser-irradiated metallic targets

Energy Technology Data Exchange (ETDEWEB)

Chen Ziyu; Li Jianfeng; Yu Yong; Li Xiaoya; Peng Qixian; Zhu Wenjun [National Key Laboratory of Shock Wave and Detonation Physics, Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan 621900 (China); Wang Jiaxiang [State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200062 (China)

2012-11-15

The influences of lateral target size on hot electron production and electromagnetic pulse emission from laser interaction with metallic targets have been investigated. Particle-in-cell simulations at high laser intensities show that the yield of hot electrons tends to increase with lateral target size, because the larger surface area reduces the electrostatic field on the target, owing to its expansion along the target surface. At lower laser intensities and longer time scales, experimental data characterizing electromagnetic pulse emission as a function of lateral target size also show target-size effects. Charge separation and a larger target tending to have a lower target potential have both been observed. The increase in radiation strength and downshift in radiation frequency with increasing lateral target size can be interpreted using a simple model of the electrical capacity of the target.

Design of a covert RFID tag network for target discovery and target information routing.

Science.gov (United States)

Pan, Qihe; Narayanan, Ram M

2011-01-01

Radio frequency identification (RFID) tags are small electronic devices working in the radio frequency range. They use wireless radio communications to automatically identify objects or people without the need for line-of-sight or contact, and are widely used in inventory tracking, object location, environmental monitoring. This paper presents a design of a covert RFID tag network for target discovery and target information routing. In the design, a static or very slowly moving target in the field of RFID tags transmits a distinct pseudo-noise signal, and the RFID tags in the network collect the target information and route it to the command center. A map of each RFID tag's location is saved at command center, which can determine where a RFID tag is located based on each RFID tag's ID. We propose the target information collection method with target association and clustering, and we also propose the information routing algorithm within the RFID tag network. The design and operation of the proposed algorithms are illustrated through examples. Simulation results demonstrate the effectiveness of the design.

Target-ion source unit ionization efficiency measurement by method of stable ion beam implantation

CERN Document Server

Panteleev, V.N; Fedorov, D.V; Moroz, F.V; Orlov, S.Yu; Volkov, Yu.M

The ionization efficiency is one of the most important parameters of an on-line used target-ion source system exploited for production of exotic radioactive beams. The ionization efficiency value determination as a characteristic of a target-ion source unit in the stage of its normalizing before on-line use is a very important step in the course of the preparation for an on-line experiment. At the IRIS facility (Petersburg Nuclear Physics Institute, Gatchina) a reliable and rather precise method of the target-ion source unit ionization efficiency measurement by the method of stable beam implantation has been developed. The method worked out exploits an off-line mass-separator for the implantation of the ion beams of selected stable isotopes of different elements into a tantalum foil placed inside the Faraday cup in the focal plane of the mass-separator. The amount of implanted ions has been measured with a high accuracy by the current integrator connected to the Faraday cup. After the implantation of needed a...

Target-present guessing as a function of target prevalence and accumulated information in visual search.

Science.gov (United States)

Peltier, Chad; Becker, Mark W

2017-05-01

Target prevalence influences visual search behavior. At low target prevalence, miss rates are high and false alarms are low, while the opposite is true at high prevalence. Several models of search aim to describe search behavior, one of which has been specifically intended to model search at varying prevalence levels. The multiple decision model (Wolfe & Van Wert, Current Biology, 20(2), 121--124, 2010) posits that all searches that end before the observer detects a target result in a target-absent response. However, researchers have found very high false alarms in high-prevalence searches, suggesting that prevalence rates may be used as a source of information to make "educated guesses" after search termination. Here, we further examine the ability for prevalence level and knowledge gained during visual search to influence guessing rates. We manipulate target prevalence and the amount of information that an observer accumulates about a search display prior to making a response to test if these sources of evidence are used to inform target present guess rates. We find that observers use both information about target prevalence rates and information about the proportion of the array inspected prior to making a response allowing them to make an informed and statistically driven guess about the target's presence.

Facility target insert shielding assessment

Energy Technology Data Exchange (ETDEWEB)

Mocko, Michal [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2015-10-06

Main objective of this report is to assess the basic shielding requirements for the vertical target insert and retrieval port. We used the baseline design for the vertical target insert in our calculations. The insert sits in the 12”-diameter cylindrical shaft extending from the service alley in the top floor of the facility all the way down to the target location. The target retrieval mechanism is a long rod with the target assembly attached and running the entire length of the vertical shaft. The insert also houses the helium cooling supply and return lines each with 2” diameter. In the present study we focused on calculating the neutron and photon dose rate fields on top of the target insert/retrieval mechanism in the service alley. Additionally, we studied a few prototypical configurations of the shielding layers in the vertical insert as well as on the top.

Gas target neutron generator studies

International Nuclear Information System (INIS)

Chatoorgoon, V.

1978-01-01

The need for an intense neutron source for the study of radiation damage on materials has resulted in the proposal of various solid, liquid, and gas targets. Among the gas targets proposed have been the transonic gas target, two types of hypersonic gas target, and the subsonic gas target (SGT). It has been suggested that heat deposition in a subsonic channel might create a gas density step which would constitute an attractive gas target type. The first part of the present study examines this aspect of the SGT and shows that gas density gradients are indeed formed by heat deposition in subsonic flow. The variation of beam voltage, gas density, gas pressure, and gas temperature within the channel have been calculated as functions of the system parameters: beam voltage, beam current, channel diameter, stagnation tank temperature and pressure. The analysis is applicable to any beam particle and target gas. For the case of T + on D 2 , which is relevant to the fusion application, the 14 MeV neutron profiles are presented as a function of system parameters. It is found that the SGT is compatible with concentrated intense source operation. The possibility of instability was investigated in detail using a non-linear analysis which made it possible to follow the complete time development of the SGT. It was found that the SGT is stable against all small perturbations and certain types of large perturbations. It appears that the SGT is the most advantageous type of gas target, operating at a lower mass flow and less severe stagnation tank conditions than the other types. The second part of the thesis examines a problem associated with the straight hypersonic target, the deuterium spill into the tritium port. The regime of practical operation for this target is established. (auth)

TAPIR, a web server for the prediction of plant microRNA targets, including target mimics.

Science.gov (United States)

Bonnet, Eric; He, Ying; Billiau, Kenny; Van de Peer, Yves

2010-06-15

We present a new web server called TAPIR, designed for the prediction of plant microRNA targets. The server offers the possibility to search for plant miRNA targets using a fast and a precise algorithm. The precise option is much slower but guarantees to find less perfectly paired miRNA-target duplexes. Furthermore, the precise option allows the prediction of target mimics, which are characterized by a miRNA-target duplex having a large loop, making them undetectable by traditional tools. The TAPIR web server can be accessed at: http://bioinformatics.psb.ugent.be/webtools/tapir. Supplementary data are available at Bioinformatics online.

Inertial-confinement-fusion targets

International Nuclear Information System (INIS)

Hendricks, C.D.

1981-01-01

Inertial confinement fusion (ICF) targets are made as simple flat discs, as hollow shells or as complicated multilayer structures. Many techniques have been devised for producing the targets. Glass and metal shells are made by using drop and bubble techniques. Solid hydrogen shells are also produced by adapting old methods to the solution of modern problems. Some of these techniques, problems and solutions are discussed. In addition, the applications of many of the techniques to fabrication of ICF targets is presented

Targets and teamwork

DEFF Research Database (Denmark)

Skinner, Timothy C.; Lange, Karin S.; Hoey, Hilary

2017-01-01

differences in mean HbA1c between centers ranging from 7.3±0.8% (53mmol/mol±8.7) to 8.9±1.1% (74mmol/mol±12.0). Centers with lower mean HbA1c had (1) parents who reported lower targets for their children, (2) health-care professionals that reported lower targets and more frequent testing, and (3) teams...

Targets and processes for fabricating same

Science.gov (United States)

Adams, Jesse D; Malekos, Steven; Le Galloudec, Nathalie; Korgan, Grant; Cowan, Thomas; Sentoku, Yasuhiko

2016-05-17

In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 .mu.m. In particular examples, the distance is less than about 1 .mu.m. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.

Targets and processes for fabricating same

Science.gov (United States)

Cowan, Thomas [Dresden, DE; Malekos, Steven [Reno, NV; Korgan, Grant [Reno, NV; Adams, Jesse [Reno, NV; Sentoku, Yasuhiko [Reno, NV; Le Galloudec, Nathalie [Reno, NV; Fuchs, Julien [Paris, FR

2012-07-24

In particular embodiments, the present disclosure provides targets including a metal layer and defining a hollow inner surface. The hollow inner surface has an internal apex. The distance between at least two opposing points of the internal apex is less than about 15 .mu.m. In particular examples, the distance is less than about 1 .mu.m. Particular implementations of the targets are free standing. The targets have a number of disclosed shaped, including cones, pyramids, hemispheres, and capped structures. The present disclosure also provides arrays of such targets. Also provided are methods of forming targets, such as the disclosed targets, using lithographic techniques, such as photolithographic techniques. In particular examples, a target mold is formed from a silicon wafer and then one or more sides of the mold are coated with a target material, such as one or more metals.

Las empresas transnacionales y el aprendizaje local: la creación de las capacidades locales de la industria mundial del automóvil Transnational corporations and local learning: creating local capabilities from the global automotive industry

Directory of Open Access Journals (Sweden)

Oscar Contreras

2010-10-01

Full Text Available Desde los años 1980 México ha adquirido una mayor importancia en la industria del automóvil en Norte América. A medida que esta industria se ha ido concentrando en torno a un reducido número de grandes empresas ensambladoras y un grupo privilegiado de suministradores transnacionales globalizados, los beneficios para las localidades receptoras se ha convertido en una cuestión controvertida. En este contexto se presenta el caso en el que se analiza el papel de los suministradores locales dentro del complejo industrial liderado por Ford Motor en Hermosilla (México. El artículo explora los mecanismos de transferencia de conocimiento de Ford a sus suministradores globales en la economía local, y la aparición de pequeñas empresas locales que ofrecen servicios de intensivos en conocimiento.Ever since the 1980s Mexico has been taking on an increasingly important role in the manufacture of automobiles for North America. As this industry has become highly concentrated, driven by a small number of very large assembly firms and a privileged group of globalized transnational suppliers, the benefits for the host localities have turned into a controversial issue. With this controversy as the background, a case study was designed to analyze the role of local suppliers within the industrial complex led by the Ford Motor Company in Hermosillo, Mexico. This article explores the mechanisms of knowledge transfer from Ford and its global suppliers to the local economy, and the emergence of small local companies that provide knowledge-intensive services.

Bispecific antibodies targeting human CD73

DEFF Research Database (Denmark)

2017-01-01

The present invention relates to a bispecific antibody targeting CD73. In particular, the present invention relates to a bispecific antibody targeting different epitopes on CD73 or a bispecific antibody targeting an epitope on CD73 and an epitope on a different antigen.......The present invention relates to a bispecific antibody targeting CD73. In particular, the present invention relates to a bispecific antibody targeting different epitopes on CD73 or a bispecific antibody targeting an epitope on CD73 and an epitope on a different antigen....

Targets for heavy ion fusion

International Nuclear Information System (INIS)

Clauser, M.J.

1978-01-01

This paper describes some of the basic principles of fusion target implosions, using some simple targets designed for irradiation by ion beams. Present estimates are that ion beams with 1-5 MJ, and 100-500 TW will be required to ignite high gain targets. (orig.) [de

Experimental methods in radioactive ion-beam target/ion source development and characterization

International Nuclear Information System (INIS)

Welton, R.F.; Alton, G.D.; Cui, B.; Murray, S.N.

1998-01-01

We have developed off-line experimental techniques and apparatuses that permit direct measurement of effusive-flow delay times and ionization efficiencies for nearly any chemically reactive element in high-temperature target/ion sources (TIS) commonly used for on-line radioactive ion-beam (RIB) generation. The apparatuses include a hot Ta valve for effusive-flow delay-time measurements, a cooled molecular injection system for determination of ionization efficiencies, and a gas flow measurement/control system for introducing very low, well-defined molecular flows into the TIS. Measurements are performed on a test stand using molecular feed compounds containing stable complements of the radioactive nuclei of interest delivered to the TIS at flow rates commensurate with on-line RIB generation. In this article, the general techniques are described and effusive-flow delay times and ionization efficiency measurements are reported for fluorine in an electron-beam plasma target/ion source developed for RIB generation and operated in both positive- and negative-ion extraction modes. copyright 1998 American Institute of Physics

Target Capture during Mos1 Transposition*

Science.gov (United States)

Pflieger, Aude; Jaillet, Jerôme; Petit, Agnès; Augé-Gouillou, Corinne; Renault, Sylvaine

2014-01-01

DNA transposition contributes to genomic plasticity. Target capture is a key step in the transposition process, because it contributes to the selection of new insertion sites. Nothing or little is known about how eukaryotic mariner DNA transposons trigger this step. In the case of Mos1, biochemistry and crystallography have deciphered several inverted terminal repeat-transposase complexes that are intermediates during transposition. However, the target capture complex is still unknown. Here, we show that the preintegration complex (i.e., the excised transposon) is the only complex able to capture a target DNA. Mos1 transposase does not support target commitment, which has been proposed to explain Mos1 random genomic integrations within host genomes. We demonstrate that the TA dinucleotide used as the target is crucial both to target recognition and in the chemistry of the strand transfer reaction. Bent DNA molecules are better targets for the capture when the target DNA is nicked two nucleotides apart from the TA. They improve strand transfer when the target DNA contains a mismatch near the TA dinucleotide. PMID:24269942

Cooperative tumour cell membrane targeted phototherapy

Science.gov (United States)

Kim, Heegon; Lee, Junsung; Oh, Chanhee; Park, Ji-Ho

2017-06-01

The targeted delivery of therapeutics using antibodies or nanomaterials has improved the precision and safety of cancer therapy. However, the paucity and heterogeneity of identified molecular targets within tumours have resulted in poor and uneven distribution of targeted agents, thus compromising treatment outcomes. Here, we construct a cooperative targeting system in which synthetic and biological nanocomponents participate together in the tumour cell membrane-selective localization of synthetic receptor-lipid conjugates (SR-lipids) to amplify the subsequent targeting of therapeutics. The SR-lipids are first delivered selectively to tumour cell membranes in the perivascular region using fusogenic liposomes. By hitchhiking with extracellular vesicles secreted by the cells, the SR-lipids are transferred to neighbouring cells and further spread throughout the tumour tissues where the molecular targets are limited. We show that this tumour cell membrane-targeted delivery of SR-lipids leads to uniform distribution and enhanced phototherapeutic efficacy of the targeted photosensitizer.

Artificial Chemical Reporter Targeting Strategy Using Bioorthogonal Click Reaction for Improving Active-Targeting Efficiency of Tumor.

Science.gov (United States)

Yoon, Hong Yeol; Shin, Min Lee; Shim, Man Kyu; Lee, Sangmin; Na, Jin Hee; Koo, Heebeom; Lee, Hyukjin; Kim, Jong-Ho; Lee, Kuen Yong; Kim, Kwangmeyung; Kwon, Ick Chan

2017-05-01

Biological ligands such as aptamer, antibody, glucose, and peptide have been widely used to bind specific surface molecules or receptors in tumor cells or subcellular structures to improve tumor-targeting efficiency of nanoparticles. However, this active-targeting strategy has limitations for tumor targeting due to inter- and intraheterogeneity of tumors. In this study, we demonstrated an alternative active-targeting strategy using metabolic engineering and bioorthogonal click reaction to improve tumor-targeting efficiency of nanoparticles. We observed that azide-containing chemical reporters were successfully generated onto surface glycans of various tumor cells such as lung cancer (A549), brain cancer (U87), and breast cancer (BT-474, MDA-MB231, MCF-7) via metabolic engineering in vitro. In addition, we compared tumor targeting of artificial azide reporter with bicyclononyne (BCN)-conjugated glycol chitosan nanoparticles (BCN-CNPs) and integrin α v β 3 with cyclic RGD-conjugated CNPs (cRGD-CNPs) in vitro and in vivo. Fluorescence intensity of azide-reporter-targeted BCN-CNPs in tumor tissues was 1.6-fold higher and with a more uniform distribution compared to that of cRGD-CNPs. Moreover, even in the isolated heterogeneous U87 cells, BCN-CNPs could bind artificial azide reporters on tumor cells more uniformly (∼92.9%) compared to cRGD-CNPs. Therefore, the artificial azide-reporter-targeting strategy can be utilized for targeting heterogeneous tumor cells via bioorthogonal click reaction and may provide an alternative method of tumor targeting for further investigation in cancer therapy.

Strategic Targeted Advertising

OpenAIRE

Andrea Galeotti; Jose Luis Moraga

2003-01-01

textabstractWe present a strategic game of pricing and targeted-advertising. Firms can simultaneously target price advertisements to different groups of customers, or to the entire market. Pure strategy equilibria do not exist and thus market segmentation cannot occur surely. Equilibria exhibit random advertising --to induce an unequal distribution of information in the market-- and random pricing --to obtain profits from badly informed buyers--. We characterize a positive profits equilibrium...

Vision-Based Target Finding and Inspection of a Ground Target Using a Multirotor UAV System.

Science.gov (United States)

Hinas, Ajmal; Roberts, Jonathan M; Gonzalez, Felipe

2017-12-17

In this paper, a system that uses an algorithm for target detection and navigation and a multirotor Unmanned Aerial Vehicle (UAV) for finding a ground target and inspecting it closely is presented. The system can also be used for accurate and safe delivery of payloads or spot spraying applications in site-specific crop management. A downward-looking camera attached to a multirotor is used to find the target on the ground. The UAV descends to the target and hovers above the target for a few seconds to inspect the target. A high-level decision algorithm based on an OODA (observe, orient, decide, and act) loop was developed as a solution to address the problem. Navigation of the UAV was achieved by continuously sending local position messages to the autopilot via Mavros. The proposed system performed hovering above the target in three different stages: locate, descend, and hover. The system was tested in multiple trials, in simulations and outdoor tests, from heights of 10 m to 40 m. Results show that the system is highly reliable and robust to sensor errors, drift, and external disturbance.

Hvad siger forskningen om feedback?

DEFF Research Database (Denmark)

Holdt Christensen, Peter

2016-01-01

”Feedback skal serveres ligesom en gammeldags sandwich. Først lidt brød, så det lidt sejere kød og til sidst igen til lidt brød”. Sådan nogenlunde lyder en pragmatisk løsning på udfordringerne ved at give feedback. Når medarbejdere skal have negativ feedback, skal denne altså pakkes ind, så...... feedbacken indledes med let fordøjeligt positiv feedback, derefter kommer den negative – og noget sværere fordøjelige – feedback, og til sidst afrundes feedbacken med en god udgangsreplik, nemlig den positive feedback....

Tippude tipud / Robert Koistinen, Aimo Niemi

Index Scriptorium Estoniae

Koistinen, Robert

2013-01-01

TM testib sportautosid: Aston Martin Vantage Special Edition, Audi RS4, Audi RS6, Audi R8 V10 FSI Plus, Bentley Continental GT V8, BMW M135i, BMW M6 Gran Coupé, Ford Fiesta ST, Ford Focus ST, Jaguar F-type V8, Kia ProCeed GT, Lamborghini Aventador, Lotus Exige S, Lotus Evora S, Mini JCW GP, Nissan Juke Nismo, Nissan GT-R 2013, Opel Astra OPC, Peugeot 208 GTI, Porsche Cayman S, Porsche 911, Carrera 4S, Volkswagen Golf GTI Performance, Volvo V40 T5, Volvo S60 T6 AWD

Indigenous Peoples and Universities in Latin America: Policies, Social Actors and Challenges

OpenAIRE

Ossola, María Macarena

2015-01-01

El artículo reseña el libro de Antonio Carlos de SOUZA LIMA y Mariana PALADINO (Organizadores). 2012. Los Programas Pathways de la Fundación Ford para pueblos indígenas en México, Perú, Brasil y Chile.E-papers, Río de Janeiro. Se trata de una revisión crítica de los impactos de la implementación de las acciones afirmativas de la Fundación Ford en Universidades de México, Perú, Chile y Brasil. Fil: Ossola, María Macarena. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Ci...

Canada regroups for a renewed met assault

Energy Technology Data Exchange (ETDEWEB)

Hayes, J. [Coal Association of Canada (Canada)

2003-08-01

An agreement in early 2003 between Canada's largest coal producers and two Vancouver area coal handling terminals has resulted in a major realignment of the national coal industry. Sherritt International Corporation and Ontario Teachers' Pension Plan have acquired the thermal coal properties previously owned by Fording, Inc.; Fording Inc. paired with Teck Comince Ltd. to form the Elk Valley Coal Corporation, suppliers of metallurgical coal. Consolidations of operations under Elk Valley Coal realised substantial operating, capital, marketing and transportation synergies and should bring huge cost savings. The article describes Elk Valley's mining operations. 1 ref., 3 photos.

Mellem Detroit og Danmark

DEFF Research Database (Denmark)

Christensen, Lars K.

2013-01-01

Danmark var et af de første steder, man producerede Ford i Europa – fra 1919 på Nørrebro – og det blev hurtigt en succes. Sidenhen tvang danske arbejdere verdens største bilproducent til at acceptere »den danske model«. Dog kun for en tid.......Danmark var et af de første steder, man producerede Ford i Europa – fra 1919 på Nørrebro – og det blev hurtigt en succes. Sidenhen tvang danske arbejdere verdens største bilproducent til at acceptere »den danske model«. Dog kun for en tid....

Om distributionen af hvidhed

DEFF Research Database (Denmark)

Frello, Birgitta

2007-01-01

Med udgangspunkt i John Fords Western, Forfølgeren fra 1956, præsenteres en analyse af repræsentationer af race og overskridelse af raceskel, særligt i relation til konstitueringen af subjektpositioner, hvorfra spørgsmål om hvidhed og ikke-hvidhed kan afgøres.......Med udgangspunkt i John Fords Western, Forfølgeren fra 1956, præsenteres en analyse af repræsentationer af race og overskridelse af raceskel, særligt i relation til konstitueringen af subjektpositioner, hvorfra spørgsmål om hvidhed og ikke-hvidhed kan afgøres....

Targeting radiation to tumours

International Nuclear Information System (INIS)

Wheldon, T.E.; Greater Glasgow Health Board, Glasgow

1994-01-01

Biologically targeted radiotherapy entails the preferential delivery of radiation to solid tumours or individual tumour cells by means of tumour-seeking delivery vehicles to which radionuclides can be conjugated. Monoclonal antibodies have attracted attention for some years as potentially selective targeting agents, but advances in tumour and molecular biology are now providing a much wider choice of molecular species. General radiobiological principles may be derived which are applicable to most forms of targeted radiotherapy. These principles provide guidelines for the appropriate choice of radionuclide in specific treatment situations and its optimal combination with other treatment modalities. In future, the availability of gene targeting agents will focus attention on the use of Auger electron emitters whose high potency and short range selectivity makes them attractive choices for specific killing of cancer cells whose genetic peculiarities are known. (author)

75 FR 8902 - Funding Opportunity Title: Crop Insurance Education in Targeted States (Targeted States Program)

Science.gov (United States)

2010-02-26

... and Target Audience D. Maximum Award E. Project Period F. Description of Agreement Award--Awardee.... Location and Target Audience Targeted States serviced by RMA Regional Offices are listed below. Staff from... established farmers or ranchers who are converting production and marketing systems to pursue new markets. D...

AA antiproton production target

CERN Multimedia

CERN PhotoLab

1979-01-01

The first version of the antiproton production target was a tungsten rod, 11 cm long and 3 mm in diameter. The rod was embedded in graphite, pressure-seated into an outer casing of stainless steel. At the entrance to the target assembly was a scintillator screen, imprinted with circles every 5 mm in radius, which allowed to precisely aim the 26 GeV high-intensity proton beam from the PS onto the centre of the target rod. The scintillator screen was a 1 mm thick plate of Cr-doped alumina. See also 7903034 and 7905091.

Impact of Target Distance, Target Size, and Visual Acuity on the Video Head Impulse Test.

Science.gov (United States)

Judge, Paul D; Rodriguez, Amanda I; Barin, Kamran; Janky, Kristen L

2018-05-01

The video head impulse test (vHIT) assesses the vestibulo-ocular reflex. Few have evaluated whether environmental factors or visual acuity influence the vHIT. The purpose of this study was to evaluate the influence of target distance, target size, and visual acuity on vHIT outcomes. Thirty-eight normal controls and 8 subjects with vestibular loss (VL) participated. vHIT was completed at 3 distances and with 3 target sizes. Normal controls were subdivided on the basis of visual acuity. Corrective saccade frequency, corrective saccade amplitude, and gain were tabulated. In the normal control group, there were no significant effects of target size or visual acuity for any vHIT outcome parameters; however, gain increased as target distance decreased. The VL group demonstrated higher corrective saccade frequency and amplitude and lower gain as compared with controls. In conclusion, decreasing target distance increases gain for normal controls but not subjects with VL. Preliminarily, visual acuity does not affect vHIT outcomes.

Target for production of X-rays

Energy Technology Data Exchange (ETDEWEB)

Korenev, S.A. E-mail: sergey_korenev@steris.com

2004-10-01

The patented new type of X-ray target is considered in this report. The main concept of the target consists in developing a sandwich structure depositing a coating of materials with high Z on the substrate with low Z, high thermal conductivity and high thermal stability. The target presents multiple layers system. The thermal conditions for X-ray target are discussed. The experimental results for Ta target on the Al and Cu substrates are presented.

Target for production of X-rays

International Nuclear Information System (INIS)

Korenev, S.A.

2004-01-01

The patented new type of X-ray target is considered in this report. The main concept of the target consists in developing a sandwich structure depositing a coating of materials with high Z on the substrate with low Z, high thermal conductivity and high thermal stability. The target presents multiple layers system. The thermal conditions for X-ray target are discussed. The experimental results for Ta target on the Al and Cu substrates are presented

Target for production of X-rays

Science.gov (United States)

Korenev, S. A.

2004-09-01

The patented new type of X-ray target is considered in this report. The main concept of the target consists in developing a sandwich structure depositing a coating of materials with high Z on the substrate with low Z, high thermal conductivity and high thermal stability. The target presents multiple layers system. The thermal conditions for X-ray target are discussed. The experimental results for Ta target on the Al and Cu substrates are presented.

Targets development at Sandia National Laboratories

International Nuclear Information System (INIS)

Smith, M.L.; Hebron, D.; Derzon, M.; Olson, R.; Alberts, T.

1997-01-01

For many years, Sandia National Laboratories under contract to the Department of Energy has produced targets designed to understand complex ion beam and z-pinch plasma physics. This poster focuses on the features of target designs that make them suitable for Z-pinch plasma physics applications. Precision diagnostic targets will prove critical in understanding the plasma physics model needed for future ion beam and z-pinch design. Targets are designed to meet specific physics needs; in this case the authors have fabricated targets to maximize information about the end-on versus side-on x-ray emission and z-pinch hohlraum development. In this poster, they describe the fabrication and characterization techniques. They include discussion of current targets under development as well as target fabrication capabilities. Advanced target designs are fabricated by Sandia National Laboratories in cooperation with General Atomics of San Diego, CA and W.J. Schafer Associates, Inc. of Livermore, CA

Spallation source neutron target systems

International Nuclear Information System (INIS)

Russell, G.; Brown, R.; Collier, M.; Donahue, J.

1996-01-01

This is the final report for a two-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The project sought to design a next-generation spallation source neutron target system for the Manuel Lujan, Jr., Neutron Scattering Center (LANSCE) at Los Alamos. It has been recognized for some time that new advanced neutron sources are needed in the US if the country is to maintain a competitive position in several important scientific and technological areas. A recent DOE panel concluded that the proposed Advanced Neutron Source (a nuclear reactor at Oak Ridge National Laboratory) and a high-power pulsed spallation source are both needed in the near future. One of the most technically challenging designs for a spallation source is the target station itself and, more specifically, the target-moderator-reflector arrangement. Los Alamos has demonstrated capabilities in designing, building, and operating high-power spallation-neutron-source target stations. Most of the new design ideas proposed worldwide for target system design for the next generation pulsed spallation source have either been conceived and implemented at LANSCE or proposed by LANSCE target system designers. These concepts include split targets, flux-trap moderators, back scattering and composite moderators, and composite reflectors

Modelling Recycling Targets

DEFF Research Database (Denmark)

Hill, Amanda Louise; Leinikka Dall, Ole; Andersen, Frits M.

2014-01-01

Within the European Union (EU) a paradigm shift is currently occurring in the waste sector, where EU waste directives and national waste strategies are placing emphasis on resource efficiency and recycling targets. The most recent Danish resource strategy calculates a national recycling rate of 22......% for household waste, and sets an ambitious goal of a 50% recycling rate by 2020. This study integrates the recycling target into the FRIDA model to project how much waste and from which streams should be diverted from incineration to recycling in order to achieve the target. Furthermore, it discusses how...... the existing technological, organizational and legislative frameworks may affect recycling activities. The results of the analysis show that with current best practice recycling rates, the 50% recycling rate cannot be reached without recycling of household biowaste. It also shows that all Danish municipalities...

Analyzing the Impact of the 2012 Ford Focus Target Hunt: Can Student Managed Projects Accomplish Both Academic and Corporate Objectives?

Science.gov (United States)

Aurand, Timothy W.; St. Clair, Jordan; Sullivan, Ursula

2012-01-01

Student-managed business projects offer students the opportunity to garner valuable real world experience while businesses can fulfill corporate responsibilities utilizing relatively inexpensive manpower. This paper describes an event marketing/social media marketing project completed in conjunction with Jackson-Dawson Communications, representing…

Utilizing random Forest QSAR models with optimized parameters for target identification and its application to target-fishing server.

Science.gov (United States)

Lee, Kyoungyeul; Lee, Minho; Kim, Dongsup

2017-12-28

The identification of target molecules is important for understanding the mechanism of "target deconvolution" in phenotypic screening and "polypharmacology" of drugs. Because conventional methods of identifying targets require time and cost, in-silico target identification has been considered an alternative solution. One of the well-known in-silico methods of identifying targets involves structure activity relationships (SARs). SARs have advantages such as low computational cost and high feasibility; however, the data dependency in the SAR approach causes imbalance of active data and ambiguity of inactive data throughout targets. We developed a ligand-based virtual screening model comprising 1121 target SAR models built using a random forest algorithm. The performance of each target model was tested by employing the ROC curve and the mean score using an internal five-fold cross validation. Moreover, recall rates for top-k targets were calculated to assess the performance of target ranking. A benchmark model using an optimized sampling method and parameters was examined via external validation set. The result shows recall rates of 67.6% and 73.9% for top-11 (1% of the total targets) and top-33, respectively. We provide a website for users to search the top-k targets for query ligands available publicly at http://rfqsar.kaist.ac.kr . The target models that we built can be used for both predicting the activity of ligands toward each target and ranking candidate targets for a query ligand using a unified scoring scheme. The scores are additionally fitted to the probability so that users can estimate how likely a ligand-target interaction is active. The user interface of our web site is user friendly and intuitive, offering useful information and cross references.

A triple axes multiple target holder assembly

International Nuclear Information System (INIS)

Tribedi, L.C.; Narvekar, S.D.; Pillay, R.G.; Tandon, P.N.

1993-01-01

We have designed and fabricated a rotatable target holder assembly capable of accommodating 27 targets. The target foils are mounted along two concentric circles on a ss wheel. On the outer circle 18 targets can be mounted each 20deg apart, and on the inner circle the remaining targets are positioned each 40deg apart. The self supporting or carbon backed targets are mounted on thin frames and are placed concentrically at the targets are mounted on thin frames and are placed concentrically at the target position on the wheel. Three degrees of freedom are provided to the target holder assembly. (author). 1 fig

Right on Target, or Is it? The Role of Distributional Shape in Variance Targeting

Directory of Open Access Journals (Sweden)

Stanislav Anatolyev

2015-08-01

Full Text Available Estimation of GARCH models can be simplified by augmenting quasi-maximum likelihood (QML estimation with variance targeting, which reduces the degree of parameterization and facilitates estimation. We compare the two approaches and investigate, via simulations, how non-normality features of the return distribution affect the quality of estimation of the volatility equation and corresponding value-at-risk predictions. We find that most GARCH coefficients and associated predictions are more precisely estimated when no variance targeting is employed. Bias properties are exacerbated for a heavier-tailed distribution of standardized returns, while the distributional asymmetry has little or moderate impact, these phenomena tending to be more pronounced under variance targeting. Some effects further intensify if one uses ML based on a leptokurtic distribution in place of normal QML. The sample size has also a more favorable effect on estimation precision when no variance targeting is used. Thus, if computational costs are not prohibitive, variance targeting should probably be avoided.

Kettlebell swing targets semitendinosus and supine leg curl targets biceps femoris

DEFF Research Database (Denmark)

Zebis, Mette Kreutzfeldt; Skotte, Jørgen; Andersen, Christoffer H

2013-01-01

The medial hamstring muscle has the potential to prevent excessive dynamic valgus and external rotation of the knee joint during sports. Thus, specific training targeting the medial hamstring muscle seems important to avoid knee injuries.......The medial hamstring muscle has the potential to prevent excessive dynamic valgus and external rotation of the knee joint during sports. Thus, specific training targeting the medial hamstring muscle seems important to avoid knee injuries....

Target cells in internal dosimetry

Energy Technology Data Exchange (ETDEWEB)

Goessner, W

2003-07-01

Data related to radium induced bone sarcomas in humans are used as a model for defining target cells on bone surfaces and in the bone marrow. The differential distribution of radiation induced bone sarcoma types with a high ratio of non-bone producing, mainly fibroblastic tumours, challenges the ICRP concept that the bone lining cells are target cells. Multipotential mesenchymal stem cells are located within the range of alpha particles, and are the most likely target cells for the fibroblastic type of bone sarcoma. The histogenesis of bone sarcomas after irradiation with alpha emitters shows that their final histopathology is not dependent on a single target cell. Each target cell has a microenvironment, which has to be regarded as a synergistic morpho-functional tissue unit. For this the concept of 'histion', a term used in general pathology, is proposed. Interactions between target cells that have been hit by alpha-particles, leading to lethal, mutational or transformation events with all components of a 'histion', will prove critical to understanding the pathogenesis of both deterministic and stochastic late effects. (author)

Target cells in internal dosimetry

International Nuclear Information System (INIS)

Goessner, W.

2003-01-01

Data related to radium induced bone sarcomas in humans are used as a model for defining target cells on bone surfaces and in the bone marrow. The differential distribution of radiation induced bone sarcoma types with a high ratio of non-bone producing, mainly fibroblastic tumours, challenges the ICRP concept that the bone lining cells are target cells. Multipotential mesenchymal stem cells are located within the range of alpha particles, and are the most likely target cells for the fibroblastic type of bone sarcoma. The histogenesis of bone sarcomas after irradiation with alpha emitters shows that their final histopathology is not dependent on a single target cell. Each target cell has a microenvironment, which has to be regarded as a synergistic morpho-functional tissue unit. For this the concept of 'histion', a term used in general pathology, is proposed. Interactions between target cells that have been hit by alpha-particles, leading to lethal, mutational or transformation events with all components of a 'histion', will prove critical to understanding the pathogenesis of both deterministic and stochastic late effects. (author)

Autonomous Target Ranging Techniques

DEFF Research Database (Denmark)

Jørgensen, Peter Siegbjørn; Jørgensen, John Leif; Denver, Troelz

2003-01-01

of this telescope, a fast determination of the range to and the motion of the detected targets are important. This is needed in order to prepare the future observation strategy for each target, i.e. when is the closest approach where imaging will be optimal. In order to quickly obtain such a determination two...... ranging strategies are presented. One is an improved laser ranger with an effective range with non-cooperative targets of at least 10,000 km, demonstrated in ground tests. The accuracy of the laser ranging will be approximately 1 m. The laser ranger may furthermore be used for trajectory determination...... of nano-gravity probes, which will perform direct mass measurements of selected targets. The other is triangulation from two spacecraft. For this method it is important to distinguish between detection and tracking range, which will be different for Bering since different instruments are used...

Drug-induced regulation of target expression

DEFF Research Database (Denmark)

Iskar, Murat; Campillos, Monica; Kuhn, Michael

2010-01-01

Drug perturbations of human cells lead to complex responses upon target binding. One of the known mechanisms is a (positive or negative) feedback loop that adjusts the expression level of the respective target protein. To quantify this mechanism systems-wide in an unbiased way, drug......-induced differential expression of drug target mRNA was examined in three cell lines using the Connectivity Map. To overcome various biases in this valuable resource, we have developed a computational normalization and scoring procedure that is applicable to gene expression recording upon heterogeneous drug treatments....... In 1290 drug-target relations, corresponding to 466 drugs acting on 167 drug targets studied, 8% of the targets are subject to regulation at the mRNA level. We confirmed systematically that in particular G-protein coupled receptors, when serving as known targets, are regulated upon drug treatment. We...

Preliminary study of mercury target structure

Energy Technology Data Exchange (ETDEWEB)

Kaminaga, Masanori; Haga, Katsuhiro; Hino, Ryutaro [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Kumasaka, Katsuyuki; Uchida, Shoji; Nakagawa, Toshi; Mori, Seiji; Nishikawa, Akira

1997-11-01

Development of a proton accelerator based neutron source (1.5 GeV, 5.3 mA (for neutron source 3.3 mA), thermal power 8 MW) is currently conducted by the Special Task Force for Neutron Science Initiative, JAERI. Preliminary design studies and related R and D of a solid metal target for the first stage (1.5 GeV, 1 mA) and a liquid metal target for both the first and second stages (1.5 GeV, 3.3 mA) are conducted by the Target Group to develop both solid and liquid metal target systems. A few kinds of target structures have been investigated in FY 1996 and the preliminary results for the target structures are described in this paper. Investigation results of alternative materials for the target container are also described in this paper. (author)

The influence of drug distribution and drug-target binding on target occupancy : The rate-limiting step approximation

NARCIS (Netherlands)

Witte, de W.E.A.; Vauquelin, G.; Graaf, van der P.H.; Lange, de E.C.M.

2017-01-01

The influence of drug-target binding kinetics on target occupancy can be influenced by drug distribution and diffusion around the target, often referred to as "rebinding" or "diffusion-limited binding". This gives rise to a decreased decline of the drug-target complex concentration as a result of a

Target imaging and backlighting diagnosis

International Nuclear Information System (INIS)

Yaakobi, B.; Shvarts, D.; Marshall, F.J.; Epstein, R.; Su, Q.

1995-01-01

The expected backlighting and self-emission images of a particular CH target to be imploded on the Omega Upgrade are calculated for a variety of experimental parameters. It is shown that to overcome the problem of target self-emission, the image has to be monochromatized with a diffracting crystal. For the target studied, the two image components are then comparable in intensity and both provide useful information on target behavior. A particularly interesting feature is the appearance in the self-emission of a circular spike which closely delineates the fuel-shell interface, but requires high spatial resolution to be observed

Target validation: linking target and chemical properties to desired product profile.

Science.gov (United States)

Wyatt, Paul G; Gilbert, Ian H; Read, Kevin D; Fairlamb, Alan H

2011-01-01

The discovery of drugs is a lengthy, high-risk and expensive business taking at least 12 years and is estimated to cost upwards of US$800 million for each drug to be successfully approved for clinical use. Much of this cost is driven by the late phase clinical trials and therefore the ability to terminate early those projects destined to fail is paramount to prevent unwanted costs and wasted effort. Although neglected diseases drug discovery is driven more by unmet medical need rather than financial considerations, the need to minimise wasted money and resources is even more vital in this under-funded area. To ensure any drug discovery project is addressing the requirements of the patients and health care providers and delivering a benefit over existing therapies, the ideal attributes of a novel drug needs to be pre-defined by a set of criteria called a target product profile. Using a target product profile the drug discovery process, clinical study design, and compound characteristics can be defined all the way back through to the suitability or druggability of the intended biochemical target. Assessment and prioritisation of the most promising targets for entry into screening programmes is crucial for maximising chances of success.

Tritium target manufacturing for use in accelerators

Science.gov (United States)

Bach, P.; Monnin, C.; Van Rompay, M.; Ballanger, A.

2001-07-01

As a neutron tube manufacturer, SODERN is now in charge of manufacturing tritium targets for accelerators, in cooperation with CEA/DAM/DTMN in Valduc. Specific deuterium and tritium targets are manufactured on request, according to the requirements of the users, starting from titanium target on copper substrate, and going to more sophisticated devices. A wide range of possible uses is covered, including thin targets for neutron calibration, thick targets with controlled loading of deuterium and tritium, rotating targets for higher lifetimes, or large size rotating targets for accelerators used in boron neutron therapy. Activity of targets lies in the 1 to 1000 Curie, diameter of targets being up to 30 cm. Special targets are also considered, including surface layer targets for lowering tritium desorption under irradiation, or those made from different kinds of occluders such as titanium, zirconium, erbium, scandium, with different substrates. It is then possible to optimize either neutron output, or lifetime and stability, or thermal behavior.

ANITA (Advanced Network for Isotope and TArget laboratories) - The urgent need for a European target preparation network

Science.gov (United States)

Schumann, Dorothea; Sibbens, Goedele; Stolarz, Anna; Eberhardt, Klaus; Lommel, Bettina; Stodel, Christelle

2018-05-01

A wide number of research fields in the nuclear sector requires high-quality and well-characterized samples and targets. Currently, only a few laboratories own or have access to the equipment allowing fulfilling such demands. Coordination of activities and sharing resources is therefore mandatory to meet the increasing needs. This very urgent issue has now been addressed by six European target laboratories with an initiative called ANITA (Advanced Network for Isotope and TArget laboratories). The global aim of ANITA is to establish an overarching research infrastructure service for isotope and target production and develop a tight cooperation between the target laboratories in Europe in order to transfer the knowledge and improve the production techniques of well-characterized samples and targets. Moreover, the interaction of the target producers with the users shall be encouraged and intensified to deliver tailor-made targets best-suited to the envisaged experiments. For the realization of this ambitious goal, efforts within the European Commission and strong support by the target-using communities will be necessary. In particular, an appropriate funding instrument has to be found and applied, enabling ANITA to develop from an initiative employed by the interested parties to a real coordination platform.

Ice targets for use at NTOF

International Nuclear Information System (INIS)

Mercer, D.J.

1992-12-01

This report describes ice targets which were used during an experiment at the Neutron Time of Flight facility (NTOF) at LAMPF. Reasons for using the ice targets are given, and the construction, refrigeration system, and target preparation are detailed. Results of the research using these ice targets will be published at a later date

Shiva target irradiation facility

International Nuclear Information System (INIS)

Manes, K.R.; Ahlstrom, H.G.; Coleman, L.W.; Storm, E.K.; Glaze, J.A.; Hurley, C.A.; Rienecker, F.; O'Neal, W.C.

1977-01-01

The first laser/plasma studies performed with the Shiva laser system will be two sided irradiations extending the data obtained by other LLL lasers to higher powers. The twenty approximately 1 TW laser pulses will reach the target simultaneously from above and below in nested pentagonal clusters. The upper and lower clusters of ten beams each are radially polarized so that they strike the target in p-polarization and maximize absorption. This geometry introduces laser system isolation problems which will be briefly discussed. The layout and types of target diagnostics will be described and a brief status report on the facility given

Legal Issues in Cyber Targeting

DEFF Research Database (Denmark)

Juhlin, Jonas Alastair

Imagine this scenario: Two states are in armed conflict with each other. In order to gain an advantage, one side launches a cyber-attack against the opponent’s computer network. The malicious malware paralyze the military computer network, as intended, but the malware spreads into the civilian...... system with physical damage to follow. This can happen and the natural question arises: What must be considered lawful targeting according to the international humanitarian law in cyber warfare? What steps must an attacker take to minimize the damage done to unlawful targets when conducting an offensive...... operation? How can the attacker separate military targets from civilian targets in cyber space? This paper addresses these questions and argues that a network (civilian or military) consist of several software components and that it is the individual components that is the target. If the components are used...