Quantum classical crossover of the escape rate in the two-parameter doubly periodic potential

Science.gov (United States)

Zhou, Bin

2005-05-01

The transition from the quantum tunneling to classical hopping for a two-parameter doubly periodic potential is investigated. According to the Chudnovsky's criterion for the first-order transition, it is shown that there is the first- or second-order transition depending on different parameters regions. The phase boundary lines between first- and second-order transitions are calculated, and a complete phase diagram is presented.

Targeted HIV Screening in Eight Emergency Departments: The DICI-VIH Cluster-Randomized Two-Period Crossover Trial.

Science.gov (United States)

Leblanc, Judith; Hejblum, Gilles; Costagliola, Dominique; Durand-Zaleski, Isabelle; Lert, France; de Truchis, Pierre; Verbeke, Geert; Rousseau, Alexandra; Piquet, Hélène; Simon, François; Pateron, Dominique; Simon, Tabassome; Crémieux, Anne-Claude

2017-10-30

This study compares the effectiveness and cost-effectiveness of nurse-driven targeted HIV screening alongside physician-directed diagnostic testing (intervention strategy) with diagnostic testing alone (control strategy) in 8 emergency departments. In this cluster-randomized, 2-period, crossover trial, 18- to 64-year-old patients presenting for reasons other than potential exposure to HIV were included. The strategy applied first was randomly assigned. During both periods, diagnostic testing was prescribed by physicians following usual care. During the intervention periods, patients were asked to complete a self-administered questionnaire. According to their answers, the triage nurse suggested performing a rapid test to patients belonging to a high-risk group. The primary outcome was the proportion of new diagnoses among included patients, which further refers to effectiveness. A secondary outcome was the intervention's incremental cost (health care system perspective) per additional diagnosis. During the intervention periods, 74,161 patients were included, 16,468 completed the questionnaire, 4,341 belonged to high-risk groups, and 2,818 were tested by nurses, yielding 13 new diagnoses. Combined with 9 diagnoses confirmed through 97 diagnostic tests, 22 new diagnoses were established. During the control periods, 74,166 patients were included, 92 were tested, and 6 received a new diagnosis. The proportion of new diagnoses among included patients was higher during the intervention than in the control periods (3.0 per 10,000 versus 0.8 per 10,000; difference 2.2 per 10,000, 95% CI 1.3 to 3.6; relative risk 3.7, 95% CI 1.4 to 9.8). The incremental cost was €1,324 per additional new diagnosis. The combined strategy of targeted screening and diagnostic testing was effective. Copyright © 2017 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.

Crossover learning of gestures in two ideomotor apraxia patients: A single case experimental design study.

Science.gov (United States)

Shimizu, Daisuke; Tanemura, Rumi

2017-06-01

Crossover learning may aid rehabilitation in patients with neurological disorders. Ideomotor apraxia (IMA) is a common sequela of left-brain damage that comprises a deficit in the ability to perform gestures to verbal commands or by imitation. This study elucidated whether crossover learning occurred in two post-stroke IMA patients without motor paralysis after gesture training approximately 2 months after stroke onset. We quantitatively analysed the therapeutic intervention history and investigated whether revised action occurred during gesture production. Treatment intervention was to examine how to influence improvement and generalisation of the ability to produce the gesture. This study used an alternating treatments single-subject design, and the intervention method was errorless learning. Results indicated crossover learning in both patients. Qualitative analysis indicated that revised action occurred during the gesture-production process in one patient and that there were two types of post-revised action gestures: correct and incorrect gestures. We also discovered that even when a comparably short time had elapsed since stroke onset, generalisation was difficult. Information transfer between the left and right hemispheres of the brain via commissural fibres is important in crossover learning. In conclusion, improvements in gesture-production skill should be made with reference to the left cerebral hemisphere disconnection hypothesis.

Effects of food intake on the pharmacokinetics of diclofenac potassium soft gelatin capsules: a single-dose, randomized, two-way crossover study.

Science.gov (United States)

Scallion, Ralph; Moore, Keith A

2009-10-01

Diclofenac potassium liquid-filled soft gelatin capsule (DPSGC) is an investigational formulation that uses dispersing agents designed to facilitate rapid and consistent absorption of this NSAID. The aim of this study was to characterize the effects of food intake on the pharmacokinetic (PK) profile of oral DPSGC at doses of 25 and 50 mg. In this open-label, randomized, single-dose (2 distinct doses), 2-way crossover bioavailability study, healthy adult volunteers were randomly assigned to receive a single dose of DPSGC 25 or 50 mg after an overnight fast (fasted condition) or high-fat breakfast (fed condition) (period 1). After 7 days, the participants received the same dose under the opposite fed/fasted condition (period 2). Serial blood samples were obtained before and through 6 hours after study drug administration. Concentrations of diclofenac in plasma were determined using HPLC, and PK profiles were studied using ANCOVA. Adverse events (AEs) were monitored and recorded on each in-clinic day. Of 47 participants included in the study, 24 received the 25-mg dose of DPSGC and 23 received the 50-mg dose. The majority of participants were male (80.9%), and the mean age was 28.6 years. The mean (SD) AUC values for the fasted and fed states were 691 (195) and 680 (184) ng x h/mL, respectively, with the 25-mg dose, and 1521 (377) and 1416 (366) ng . h/mL, respectively, with the 50-mg dose, suggesting that the extent of absorption was similar with both dietary conditions at each dose. Food intake was associated with decreases in C(max) by nearly half in the 25-mg group (fasted vs fed, 1156 [482] vs 686 [411] ng/mL, respectively; P < 0.05) and the 50-mg group (2365 [1034] vs 1154 [592 ng/mL; P < 0.05) and delayed T(max) in the 25-mg group (0.49 [0.16] vs 1.02 [0.55] hours; P < 0.05) and 50-mg group (0.51 [0.19] vs 1.28 [0.71] hours; P < 0.05). Two mild AEs (nasal congestion and light-headedness) were reported in 2 participants who received 25 mg under fed conditions

Two-way regularization for MEG source reconstruction via multilevel coordinate descent

KAUST Repository

Siva Tian, Tian

2013-12-01

Magnetoencephalography (MEG) source reconstruction refers to the inverse problem of recovering the neural activity from the MEG time course measurements. A spatiotemporal two-way regularization (TWR) method was recently proposed by Tian et al. to solve this inverse problem and was shown to outperform several one-way regularization methods and spatiotemporal methods. This TWR method is a two-stage procedure that first obtains a raw estimate of the source signals and then refines the raw estimate to ensure spatial focality and temporal smoothness using spatiotemporal regularized matrix decomposition. Although proven to be effective, the performance of two-stage TWR depends on the quality of the raw estimate. In this paper we directly solve the MEG source reconstruction problem using a multivariate penalized regression where the number of variables is much larger than the number of cases. A special feature of this regression is that the regression coefficient matrix has a spatiotemporal two-way structure that naturally invites a two-way penalty. Making use of this structure, we develop a computationally efficient multilevel coordinate descent algorithm to implement the method. This new one-stage TWR method has shown its superiority to the two-stage TWR method in three simulation studies with different levels of complexity and a real-world MEG data analysis. © 2013 Wiley Periodicals, Inc., A Wiley Company.

Seismic isolation of two dimensional periodic foundations

International Nuclear Information System (INIS)

Yan, Y.; Mo, Y. L.; Laskar, A.; Cheng, Z.; Shi, Z.; Menq, F.; Tang, Y.

2014-01-01

Phononic crystal is now used to control acoustic waves. When the crystal goes to a larger scale, it is called periodic structure. The band gaps of the periodic structure can be reduced to range from 0.5 Hz to 50 Hz. Therefore, the periodic structure has potential applications in seismic wave reflection. In civil engineering, the periodic structure can be served as the foundation of upper structure. This type of foundation consisting of periodic structure is called periodic foundation. When the frequency of seismic waves falls into the band gaps of the periodic foundation, the seismic wave can be blocked. Field experiments of a scaled two dimensional (2D) periodic foundation with an upper structure were conducted to verify the band gap effects. Test results showed the 2D periodic foundation can effectively reduce the response of the upper structure for excitations with frequencies within the frequency band gaps. When the experimental and the finite element analysis results are compared, they agree well with each other, indicating that 2D periodic foundation is a feasible way of reducing seismic vibrations.

Three-way, three-period, crossover bioequivalence study of single oral dose of three brands of 300 mg phenytoin sodium tablets marketed in India, on healthy Indian human volunteers.

Science.gov (United States)

Doshi, Maulik S; Naik, Anuja A; Mehta, Mohit R; Gogtay, Nithya J; Thatte, Urmila M; Menon, Mala D

2013-10-01

To compare the bioavailability of two brands of phenytoin sodium tablets available in the Indian market using Eptoin™ as the reference. A randomized, assessor-blind, three-way crossover design study was carried out over a period of 6 months after approval from the Institutional Review Board (IRB). Twenty-two healthy male participants received a single oral 300 mg oral tablet of either of the formulations with a 2-week washout. Blood samples were collected predose and at regular intervals postdose. Plasma phenytoin levels were estimated by high-performance liquid chromatography. Calculation of Cmax, AUC0-t, and AUC0-∞ was done by the linear trapezoidal rule and 90-110% margin (90% confidence interval (CI)) was used to assess bioequivalence. Twenty volunteers completed the study. It was seen that the log-transformed values of Cmax, AUC0-t, and AUC0-∞ of the test formulations were not within the specified limits. Bioinequivalence of available phenytoin brands indicates that switching brands could lead to variations in blood concentrations and thus impact safety and efficacy. If a brand switch is done for any reason, stringent drug-level monitoring is advised.

Two-way and three-way negativities of three-qubit entangled states

International Nuclear Information System (INIS)

Sharma, S. Shelly; Sharma, N. K.

2007-01-01

We propose to quantify three-qubit entanglement using global negativity along with K-way negativities, where K=2 and 3. The principle underlying the definition of K-way negativity for pure and mixed states of N subsystems is a positive partial transpose sufficient condition. However, K-way partial transpose with respect to a subsystem is defined so as to shift the focus to K-way coherences instead of K subsystems of the composite system. A quantum state of a three-qubit system is characterized by the coherences measured by global, two-way, and three-way negativities. For a canonical state of three-qubit system, entanglement measures for genuine tripartite entanglement, W-like entanglement, and bipartite entanglement can be related to two-way and three-way negativities

Influence of pressure and interactions strength on hysteretic behavior in two-dimensional polymeric spin crossover compounds

Energy Technology Data Exchange (ETDEWEB)

Chiruta, Daniel [GEMAC, Université de Versailles Saint-Quentin-en-Yvelines, CNRS-UVSQ (UMR 8635), 78035 Versailles Cedex (France); LISV, Université de Versailles Saint-Quentin-en-Yvelines, 78140 Velizy (France); Faculty of Electrical Engineering and Computer Science, Stefan cel Mare University, 720229 Suceava (Romania); Linares, Jorge [GEMAC, Université de Versailles Saint-Quentin-en-Yvelines, CNRS-UVSQ (UMR 8635), 78035 Versailles Cedex (France); Richard Dahoo, Pierre [LATMOS, Université de Versailles-Saint-Quentin-en-Yvelines, CNRS-UPMC-UVSQ (UMR 8190), 78280 Guyancourt (France); Dimian, Mihai, E-mail: dimian@usv.ro [Faculty of Electrical Engineering and Computer Science, Stefan cel Mare University, 720229 Suceava (Romania)

2014-02-15

A study of thermal behavior for two-dimensional spin-crossover compounds is performed by using an Ising-like model including both short-range and long-range interactions and a Monte Carlo entropic sampling technique for determining the associated density of states. The effects of various factors, such as external pressure, internal interaction strength or system size, on the thermal transition are analyzed and compared to several experimental findings in this area. The study is focused on two-step transitions and the conditions for hysteresis behavior at each step which are especially important for the potential applications of spin-crossover materials in data storage devices or smart sensors.

Two- to three-dimensional crossover in a dense electron liquid in silicon

Science.gov (United States)

Matmon, Guy; Ginossar, Eran; Villis, Byron J.; Kölker, Alex; Lim, Tingbin; Solanki, Hari; Schofield, Steven R.; Curson, Neil J.; Li, Juerong; Murdin, Ben N.; Fisher, Andrew J.; Aeppli, Gabriel

2018-04-01

Doping of silicon via phosphine exposures alternating with molecular beam epitaxy overgrowth is a path to Si:P substrates for conventional microelectronics and quantum information technologies. The technique also provides a well-controlled material for systematic studies of two-dimensional lattices with a half-filled band. We show here that for a dense (ns=2.8 ×1014 cm-2) disordered two-dimensional array of P atoms, the full field magnitude and angle-dependent magnetotransport is remarkably well described by classic weak localization theory with no corrections due to interaction. The two- to three-dimensional crossover seen upon warming can also be interpreted using scaling concepts developed for anistropic three-dimensional materials, which work remarkably except when the applied fields are nearly parallel to the conducting planes.

Two types of mental fatigue affect spontaneous oscillatory brain activities in different ways

OpenAIRE

Shigihara, Yoshihito; Tanaka, Masaaki; Ishii, Akira; Kanai, Etsuko; Funakura, Masami; Watanabe, Yasuyoshi

2013-01-01

Abstract Background Fatigue has a multi-factorial nature. We examined the effects of two types of mental fatigue on spontaneous oscillatory brain activity using magnetoencephalography (MEG). Methods Participants were randomly assigned to two groups in a single-blinded, crossover fashion to perform two types of mental fatigue-inducing experiments. Each experiment consisted of a 30-min fatigue-inducing 0- or 2-back test session and two evaluation sessions performed just before and after the fat...

Inhibitory effects of intravenous lansoprazole 30 mg and pantoprazole 40 mg twice daily on intragastric acidity in healthy Chinese volunteers: a randomized, open-labeled, two-way crossover study.

Science.gov (United States)

Zhan, Xian-Bao; Guo, Xiao-Rong; Li, Zhao-Shen; Gong, Yan-Fang; Gao, Jun; Liao, Zhuan; Li, Zhen; Gao, Shen; Liu, Pei

2012-02-01

Until now there has been no study that directly compares the effect of lansoprazole and pantoprazole administered intravenously on intragastric acidity. The aim of this study is to compare the effect of lansoprazole (30 mg) and pantoprazole (40 mg) administered intravenously on gastric acidity. Helicobacter pylori-negative healthy volunteers were recruited in this open-label, randomized, two-way crossover, single centre study. Lansoprazole at 30 mg or pantoprazole at 40 mg was intravenously administered twice daily for 5 consecutive days with at least a 14-day washout interval. Twenty-four-hour intragastric pH was continuously monitored on days 1 and 5 of each dosing period. Twenty-five volunteers completed the 2 dosing periods. The mean intragastric pH values were higher in subjects treated with lansoprazole than those with pantoprazole on both day 1 (6.41 ± 0.14 vs. 5.49 ± 0.13, P=0.0003) and day 5 (7.09 ± 0.07 vs. 6.64 ± 0.07, P=0.0002). Significantly higher percentages of time with intragastric pH >4 and pH >6 were found in the subjects treated with lansoprazole than those with pantoprazole on day 1 (pH >4, 87.12 ± 4.55% vs. 62.28 ± 4.15%, P=0.0012; pH >6, 62.12 ± 4.12% vs. 47.25 ± 3.76%, P=0.0216) and pH >6 on day 5 (76.79 ± 3.77% vs. 58.20 ± 3.77%, P=0.0025). Intravenous lansoprazole produces a longer and more potent inhibitory effect on intragastric acidity than does intravenous pantoprazole.

FVCOM one-way and two-way nesting using ESMF: Development and validation

Science.gov (United States)

Qi, Jianhua; Chen, Changsheng; Beardsley, Robert C.

2018-04-01

Built on the Earth System Modeling Framework (ESMF), the one-way and two-way nesting methods were implemented into the unstructured-grid Finite-Volume Community Ocean Model (FVCOM). These methods help utilize the unstructured-grid multi-domain nesting of FVCOM with an aim at resolving the multi-scale physical and ecosystem processes. A detail of procedures on implementing FVCOM into ESMF was described. The experiments were made to validate and evaluate the performance of the nested-grid FVCOM system. The first was made for a wave-current interaction case with a two-domain nesting with an emphasis on qualifying a critical need of nesting to resolve a high-resolution feature near the coast and harbor with little loss in computational efficiency. The second was conducted for the pseudo river plume cases to examine the differences in the model-simulated salinity between one-way and two-way nesting approaches and evaluate the performance of mass conservative two-way nesting method. The third was carried out for the river plume case in the realistic geometric domain in Mass Bay, supporting the importance for having the two-way nesting for coastal-estuarine integrated modeling. The nesting method described in this paper has been used in the Northeast Coastal Ocean Forecast System (NECOFS)-a global-regional-coastal nesting FVCOM system that has been placed into the end-to-end forecast and hindcast operations since 2007.

Accumulation of unstable periodic orbits and the stickiness in the two-dimensional piecewise linear map.

Science.gov (United States)

Akaishi, A; Shudo, A

2009-12-01

We investigate the stickiness of the two-dimensional piecewise linear map with a family of marginal unstable periodic orbits (FMUPOs), and show that a series of unstable periodic orbits accumulating to FMUPOs plays a significant role to give rise to the power law correlation of trajectories. We can explicitly specify the sticky zone in which unstable periodic orbits whose stability increases algebraically exist, and find that there exists a hierarchy in accumulating periodic orbits. In particular, the periodic orbits with linearly increasing stability play the role of fundamental cycles as in the hyperbolic systems, which allows us to apply the method of cycle expansion. We also study the recurrence time distribution, especially discussing the position and size of the recurrence region. Following the definition adopted in one-dimensional maps, we show that the recurrence time distribution has an exponential part in the short time regime and an asymptotic power law part. The analysis on the crossover time T(c)(*) between these two regimes implies T(c)(*) approximately -log[micro(R)] where micro(R) denotes the area of the recurrence region.

Multi-modal distribution crossover method based on two crossing segments bounded by selected parents applied to multi-objective design optimization

Energy Technology Data Exchange (ETDEWEB)

Ariyarit, Atthaphon; Kanazaki, Masahiro [Tokyo Metropolitan University, Tokyo (Japan)

2015-04-15

This paper discusses airfoil design optimization using a genetic algorithm (GA) with multi-modal distribution crossover (MMDX). The proposed crossover method creates four segments from four parents, of which two segments are bounded by selected parents and two segments are bounded by one parent and another segment. After these segments are defined, four offsprings are generated. This study applied the proposed optimization to a real-world, multi-objective airfoil design problem using class-shape function transformation parameterization, which is an airfoil representation that uses polynomial function, to investigate the effectiveness of this algorithm. The results are compared with the results of the blend crossover (BLX) and unimodal normal distribution crossover (UNDX) algorithms. The objective of these airfoil design problems is to successfully find the optimal design. The outcome of using this algorithm is superior to that of the BLX and UNDX crossover methods because the proposed method can maintain higher diversity than the BLX and UNDX methods. This advantage is desirable for real-world problems.

Multi-modal distribution crossover method based on two crossing segments bounded by selected parents applied to multi-objective design optimization

International Nuclear Information System (INIS)

Ariyarit, Atthaphon; Kanazaki, Masahiro

2015-01-01

This paper discusses airfoil design optimization using a genetic algorithm (GA) with multi-modal distribution crossover (MMDX). The proposed crossover method creates four segments from four parents, of which two segments are bounded by selected parents and two segments are bounded by one parent and another segment. After these segments are defined, four offsprings are generated. This study applied the proposed optimization to a real-world, multi-objective airfoil design problem using class-shape function transformation parameterization, which is an airfoil representation that uses polynomial function, to investigate the effectiveness of this algorithm. The results are compared with the results of the blend crossover (BLX) and unimodal normal distribution crossover (UNDX) algorithms. The objective of these airfoil design problems is to successfully find the optimal design. The outcome of using this algorithm is superior to that of the BLX and UNDX crossover methods because the proposed method can maintain higher diversity than the BLX and UNDX methods. This advantage is desirable for real-world problems.

Two measures of bilingualism in the memories of immigrants and indigenous minorities: crossover memories and codeswitching.

Science.gov (United States)

Altman, Carmit

2015-04-01

Two indices of bilingualism, crossover memories and codeswitching (CS), were explored in five groups of immigrant (English-Hebrew, Georgian-Hebrew Russian-Hebrew) and indigenous bilinguals (Arabic-Hebrew, Hebrew-English). Participants recalled memories in response to cue words and then were asked to report the language of retrieval and provide a more elaborate narrative. More memories were 'same language' memories, recalled in the language of the experimental session/cue word, but as many as 48 % of the memories were crossovers, i.e. memories reported in a language other than the language of the session/cue word. In an effort to examine the ecological validity of the self-reported language of the memories, the frequency of CS in the elaborated narratives was investigated. For the entire sample, more CS was found for self-reported crossover memories in L2 sessions. In a further analysis of CS in crossover memories, collapsed across L1 and L2 sessions, significant differences emerged between immigrants and indigenous bilinguals. Differences between immigrant and non-immigrant bilinguals are discussed in terms of the role of activation in crossover memories.

Separating variables in two-way diffusion equations

International Nuclear Information System (INIS)

Fisch, N.J.; Kruskal, M.D.

1979-10-01

It is shown that solutions to a class of diffusion equations of the two-way type may be found by a method akin to separation of variables. The difficulty with such equations is that the boundary data must be specified partly as initial and partly as final conditions. In contrast to the one-way diffusion equation, where the solution separates only into decaying eigenfunctions, the two-way equations separate into both decaying and growing eigenfunctions. Criteria are set forth for the existence of linear eigenfunctions, which may not be found directly by separating variables. A speculation with interesting ramifications is that the growing and decaying eigenfunctions are separately complete in an appropriate half of the problem domain

Non-perturbative effects in two-dimensional lattice O(N) models

International Nuclear Information System (INIS)

Ogilvie, M.C.; Maryland Univ., College Park

1981-01-01

Non-abelian analogues of Kosterlitz-Thouless vortices may have important effects in two-dimensional lattice spin systems with O(N) symmetries. Renormalization group equations which include these effects are developed in two ways. The first set of equations extends the renormalization group equations of Kosterlitz to 0(N) spin systems, in a form suggested by Cardy and Hamber. The second is derived from a Villain-type 0(N) model using Migdal's recursion relations. Using these equations, the part played by topological excitations int he crossover from weak to strong coupling behavior is studied. Another effect which influences crossover behavior is also discussed; irrelevant operators which occur naturally in lattice theories can make important contributions to the renormalization group flow in the crossover region. When combined with conventional perturbative results, these two effects may explain the observed crossover behavior of these models. (orig.)

Numerical simulation of the optimal two-mode attacks for two-way continuous-variable quantum cryptography in reverse reconciliation

International Nuclear Information System (INIS)

Zhang, Yichen; Zhao, Yijia; Yu, Song; Li, Zhengyu; Guo, Hong

2017-01-01

We analyze the security of the two-way continuous-variable quantum key distribution protocol in reverse reconciliation against general two-mode attacks, which represent all accessible attacks at fixed channel parameters. Rather than against one specific attack model, the expression of secret key rates of the two-way protocol are derived against all accessible attack models. It is found that there is an optimal two-mode attack to minimize the performance of the protocol in terms of both secret key rates and maximal transmission distances. We identify the optimal two-mode attack, give the specific attack model of the optimal two-mode attack and show the performance of the two-way protocol against the optimal two-mode attack. Even under the optimal two-mode attack, the performances of two-way protocol are still better than the corresponding one-way protocol, which shows the advantage of making double use of the quantum channel and the potential of long-distance secure communication using a two-way protocol. (paper)

Diffusionless phase transition with two order parameters in spin-crossover solids

Energy Technology Data Exchange (ETDEWEB)

Gudyma, Iurii, E-mail: yugudyma@gmail.com; Ivashko, Victor [Department of General Physics, Chernivtsi National University, 58012 Chernivtsi (Ukraine); Linares, Jorge [Groupe d' Etude de la Matière Condensée (GEMAC), UMR 8635, CNRS, Université de Versailles Saint Quentin, 45 avenue des Etats-Unis, 78035 Versailles (France)

2014-11-07

The quantitative analysis of the interface boundary motion between high-spin and low-spin phases is presented. The nonlinear effect of the switching front rate on the temperature is shown. A compressible model of spin-crossover solid is studied in the framework of the Ising-like model with two-order parameters under statistical approach, where the effect of elastic strain on interaction integral is considered. These considerations led to examination of the relation between the order parameters during temperature changes. Starting from the phenomenological Hamiltonian, entropy has been derived using the mean field approach. Finally, the phase diagram, which characterizes the system, is numerically analyzed.

A Randomized, Two-Way Crossover Study to Evaluate the Pharmacokinetics of Caffeine Delivered Using Caffeinated Chewing Gum Versus a Marketed Caffeinated Beverage in Healthy Adult Volunteers.

Science.gov (United States)

Sadek, Paul; Pan, Xiao; Shepherd, Phil; Malandain, Elise; Carney, John; Coleman, Hugh

2017-12-01

Background: This study was conducted to compare the pharmacokinetics of caffeine delivered using caffeinated chewing gum to that delivered using a marketed caffeinated beverage (instant coffee) in 16 healthy adult volunteers. Materials and Methods: This was a controlled open-label, randomized, two-period crossover study. Caffeinated chewing gum and a serving of instant coffee, each containing ∼50 mg caffeine, were administered with blood samples collected before and up to 24 hours after administration starts. Plasma caffeine levels were analyzed using validated liquid chromatography coupled with tandem mass spectrometry methodology. Results: There were no statistical differences between the two caffeine products in t max ( p  = 0.3308) and k a ( p  = 0.3894). Although formulated at ∼50 mg caffeine each, mean dose released from chewing gum was ∼18% less than beverage. Dose-normalized area under the concentration-time curve (AUC) 0-t , AUC 0-∞ , and C max was similar between products. Although the criteria were not set a priori and the study was not powered for concluding bioequivalence, the 90% confidence intervals fell within the bioequivalence limit of 80% to 125%. Conclusions: Existing scientific literature on caffeine, based mostly on data from caffeinated beverages, can be leveraged to support the safety of caffeine delivered by chewing gum and current maximum safe caffeine dose advice should be applicable irrespective of delivery method.

Two randomized cross-over trials assessing the impact of dietary gluten or wholegrain on the gut microbiome and host metabolic health

DEFF Research Database (Denmark)

Ibrügger, Sabine; Gøbel, Rikke Juul; Vestergaard, Henrik

2014-01-01

as baseline characteristics of two human intervention studies, within the Gut, Grain and Greens (3G) Center, investigating the effects of a gluten-poor and wholegrain-rich diet on microbiota composition and metabolic health. Design: The gluten and wholegrain studies had a randomized, controlled, cross......-over design each comprising two eight-week dietary intervention periods, separated by a six-week wash-out period. Each trial included 60 men and women exhibiting an increased metabolic risk. In the gluten study a gluten-poor diet was compared with a gluten-rich dietary fiber-controlled diet......, and in the wholegrain study a wholegrain-rich diet was compared with a refined grain diet. The control diet was identical in both studies, being concomitantly high in gluten and refined. Participants substituted all cereal products with provided intervention products which they consumed ad libitum. Before and after...

Comparative analysis of the performance of One-Way and Two-Way urban road networks

Science.gov (United States)

Gheorghe, Carmen

2017-10-01

The fact that the number of vehicles is increasing year after year represents a challenge in road traffic management because it is necessary to adjust the road traffic, in order to prevent any incidents, using mostly the same road infrastructure. At this moment one-way road network provides efficient traffic flow for vehicles but it is not ideal for pedestrians. Therefore, a proper solution must be found and applied when and where it is necessary. Replacing one-way road network with two-way road network may be a viable solution especially if in the area is high pedestrian traffic. The paper aims to highlight the influence of both, one-way and two-way urban road networks through an experimental research which was performed by using traffic data collected in the field. Each of the two scenarios analyzed were based on the same traffic data, the same geometrical conditions of the road (lane width, total road segment width, road slopes, total length of the road network) and also the same signaling conditions (signalised intersection or roundabout). The analysis which involves two-way scenario reveals changes in the performance parameters like delay average, stops average, delay stop average and vehicle speed average. Based on the values obtained, it was possible to perform a comparative analysis between the real, one-way, scenario and the theoretical, two-way, scenario.

Two-way digital communications

Science.gov (United States)

Glenn, William E.; Daly, Ed

1996-03-01

The communications industry has been rapidly converting from analog to digital communications for audio, video, and data. The initial applications have been concentrating on point-to-multipoint transmission. Currently, a new revolution is occurring in which two-way point-to-point transmission is a rapidly growing market. The system designs for video compression developed for point-to-multipoint transmission are unsuitable for this new market as well as for satellite based video encoding. A new system developed by the Space Communications Technology Center has been designed to address both of these newer applications. An update on the system performance and design will be given.

Moments Based Framework for Performance Analysis of One-Way/Two-Way CSI-Assisted AF Relaying

KAUST Repository

Xia, Minghua

2012-09-01

When analyzing system performance of conventional one-way relaying or advanced two-way relaying, these two techniques are always dealt with separately and, thus, their performance cannot be compared efficiently. Moreover, for ease of mathematical tractability, channels considered in such studies are generally assumed to be subject to Rayleigh fading or to be Nakagami-$m$ channels with integer fading parameters, which is impractical in typical urban environments. In this paper, we propose a unified moments-based framework for general performance analysis of channel-state-information (CSI) assisted amplify-and-forward (AF) relaying systems. The framework is applicable to both one-way and two-way relaying over arbitrary Nakagami-$m$ fading channels, and it includes previously reported results as special cases. Specifically, the mathematical framework is firstly developed under the umbrella of the weighted harmonic mean of two Gamma-distributed variables in conjunction with the theory of Pad\\\\\\'e approximants. Then, general expressions for the received signal-to-noise ratios of the users in one-way/two-way relaying systems and the corresponding moments, moment generation function, and cumulative density function are established. Subsequently, the mathematical framework is applied to analyze, compare, and gain insights into system performance of one-way and two-way relaying techniques, in terms of outage probability, average symbol error probability, and achievable data rate. All analytical results are corroborated by simulation results as well as previously reported results whenever available, and they are shown to be efficient tools to evaluate and compare system performance of one-way and two-way relaying.

Relay Selection and Resource Allocation in One-Way and Two-Way Cognitive Relay Networks

KAUST Repository

Alsharoa, Ahmad M.

2013-05-08

In this work, the problem of relay selection and resource power allocation in one- way and two-way cognitive relay networks using half duplex channels with different relaying protocols is investigated. Optimization problems for both single and multiple relay selection that maximize the sum rate of the secondary network without degrading the quality of service of the primary network by respecting a tolerated interference threshold were formulated. Single relay selection and optimal power allocation for two-way relaying cognitive radio networks using decode-and-forward and amplify-and-forward protocols were studied. Dual decomposition and subgradient methods were used to find the optimal power allocation. The transmission process to exchange two different messages between two transceivers for two-way relaying technique takes place in two time slots. In the first slot, the transceivers transmit their signals simultaneously to the relay. Then, during the second slot the relay broadcasts its signal to the terminals. Moreover, improvement of both spectral and energy efficiency can be achieved compared with the one-way relaying technique. As an extension, a multiple relay selection for both one-way and two-way relaying under cognitive radio scenario using amplify-and-forward were discussed. A strong optimization tool based on genetic and iterative algorithms was employed to solve the 
formulated optimization problems for both single and multiple relay selection, where discrete relay power levels were considered. Simulation results show that the practical and low-complexity heuristic approaches achieve almost the same performance of the optimal relay selection schemes either with discrete or continuous power distributions while providing a considerable saving in terms of computational complexity.

Investigation of pedestrian crashes on two-way two-lane rural roads in Ethiopia.

Science.gov (United States)

Tulu, Getu Segni; Washington, Simon; Haque, Md Mazharul; King, Mark J

2015-05-01

Understanding pedestrian crash causes and contributing factors in developing countries is critically important as they account for about 55% of all traffic crashes. Not surprisingly, considerable attention in the literature has been paid to road traffic crash prediction models and methodologies in developing countries of late. Despite this interest, there are significant challenges confronting safety managers in developing countries. For example, in spite of the prominence of pedestrian crashes occurring on two-way two-lane rural roads, it has proven difficult to develop pedestrian crash prediction models due to a lack of both traffic and pedestrian exposure data. This general lack of available data has further hampered identification of pedestrian crash causes and subsequent estimation of pedestrian safety performance functions. The challenges are similar across developing nations, where little is known about the relationship between pedestrian crashes, traffic flow, and road environment variables on rural two-way roads, and where unique predictor variables may be needed to capture the unique crash risk circumstances. This paper describes pedestrian crash safety performance functions for two-way two-lane rural roads in Ethiopia as a function of traffic flow, pedestrian flows, and road geometry characteristics. In particular, random parameter negative binomial model was used to investigate pedestrian crashes. The models and their interpretations make important contributions to road crash analysis and prevention in developing countries. They also assist in the identification of the contributing factors to pedestrian crashes, with the intent to identify potential design and operational improvements. Copyright © 2015. Published by Elsevier Ltd.

A single-dose, randomized, two-way crossover study comparing two olanzapine tablet products in healthy adult male volunteers under fasting conditions.

Science.gov (United States)

Elshafeey, Ahmed H; Elsherbiny, Mohamed A; Fathallah, Mohsen M

2009-03-01

Olanzapine is a psychotropic agent that belongs to the thienobenzodiazepine class. The aim of this study was to assess the bioequivalence of 2 commercial 10-mg tablet formulations of olanzapine by statistical analysis of the pharmacokinetic parameters C(max), AUC from 0 to 72 hours after dosing (AUC(0-72)), and AUC(0-infinity) as required by the Egyptian health authority for the marketing of a generic product. This bioequivalence study was carried out in healthy male volunteers using a single-dose, randomized, 2-way crossover design under fasting conditions. Statistical analysis of the pharmacokinetic parameters C(max), AUC(0-72), and AUC(0-infinity) was conducted to determine bioequivalence (after log-transformation of data using analysis of variance and 90% CIs) and to gain marketing approval in Egypt. The formulations were considered to be bioequivalent if the log-transformed ratios of the 3 pharmacokinetic parameters were within the predetermined bioequivalence range (ie, 80%-125%), as established by the US Food and Drug Administration (FDA). Both the test product (Trademark: Integrol((R)) [Global Napi Pharmaceuticals, Cairo, Egypt]) and the reference product (Trademark: Zyprexa((R)) [Eli Lilly and Company, Basingstoke, Hampshire, United Kingdom]) were administered as 10-mg tablets with 240 mL of water after an overnight fast on 2 treatment days, separated by a 2-week washout period. After dosing, serial blood samples were collected for 72 hours. Plasma samples were analyzed using a sensitive, reproducible, and accurate liquid chromatography-tandem mass spectrometry method capable of quantitating olanzapine in the range of 0.167 to 16.7 ng/mL, with a lower limit of quantitation of 0.167 ng/mL. Adverse events were reported by the volunteers as instructed or observed by the resident physician, and were recorded, tabulated, and evaluated. Twenty-four healthy adult male volunteers participated in this study. Their mean (SD) age was 24.7 (6.2) years (range, 19

Coordination of Cooperative Advertising in a Two-Period Fashion and Textiles Supply Chain

Directory of Open Access Journals (Sweden)

Yi He

2014-01-01

Full Text Available Previous studies related to cooperative advertising mainly focus on the one-period supply chain. In the fashion and textiles (FT supply chain, the demand of most FT products (fashion clothing, vogue handbags, fashion shoes, and so on varies over time due to the trends of fashion. In these conditions, a decision-making framework with a multiple-period supply chain becomes more realistic. In view of this, we investigate the optimal cooperative advertising strategies in a two-period FT supply chain consisting of a manufacturer and a retailer in two different scenarios: (i each channel member makes decisions within a cooperative program; (ii the retailer is vertically integrated with a manufacturer. Also, we introduce a two-way subsidy contract to coordinate the supply chain.

Deterministic one-way simulation of two-way, real-time cellular automata and its related problems

Energy Technology Data Exchange (ETDEWEB)

Umeo, H; Morita, K; Sugata, K

1982-06-13

The authors show that for any deterministic two-way, real-time cellular automaton, m, there exists a deterministic one-way cellular automation which can simulate m in twice real-time. Moreover the authors present a new type of deterministic one-way cellular automata, called circular cellular automata, which are computationally equivalent to deterministic two-way cellular automata. 7 references.

General immunity and superadditivity of two-way Gaussian quantum cryptography.

Science.gov (United States)

Ottaviani, Carlo; Pirandola, Stefano

2016-03-01

We consider two-way continuous-variable quantum key distribution, studying its security against general eavesdropping strategies. Assuming the asymptotic limit of many signals exchanged, we prove that two-way Gaussian protocols are immune to coherent attacks. More precisely we show the general superadditivity of the two-way security thresholds, which are proven to be higher than the corresponding one-way counterparts in all cases. We perform the security analysis first reducing the general eavesdropping to a two-mode coherent Gaussian attack, and then showing that the superadditivity is achieved by exploiting the random on/off switching of the two-way quantum communication. This allows the parties to choose the appropriate communication instances to prepare the key, accordingly to the tomography of the quantum channel. The random opening and closing of the circuit represents, in fact, an additional degree of freedom allowing the parties to convert, a posteriori, the two-mode correlations of the eavesdropping into noise. The eavesdropper is assumed to have no access to the on/off switching and, indeed, cannot adapt her attack. We explicitly prove that this mechanism enhances the security performance, no matter if the eavesdropper performs collective or coherent attacks.

Two-stage crossover from thermal to quantum flux creep of dilute vortex ensembles in various high-Tc superconducting thin films

International Nuclear Information System (INIS)

Akerman, Johan J.; Venturini, E. L.; Siegal, M. P.; Yun, S. H.; Karlsson, U. O.; Rao, K. V.

2001-01-01

The thermal-to-quantum flux creep crossover at low vortex densities has been studied in YBa 2 Cu 3 O 7 , TlBa 2 CaCu 2 O 7-δ , and HgBa 2 CaCu 2 O 6+δ thin films using ac susceptibility. The crossover temperatures T cr are 10--11, 17, and 30 K, respectively. Both thermal and quantum flux creep is suppressed as the vortex density is decreased. We observe a two-stage nature in the crossover behavior which appears to be a general property of all the three materials studied

Comparative bioavailability and pharmacokinetics of two oral formulations of flurbiprofen: a single-dose, randomized, open-label, two-period, crossover study in Pakistani subjects.

Science.gov (United States)

Qayyum, Aisha; Najmi, Muzammil Hasan; Abbas, Mateen

2013-11-01

Comparative bioavailability studies are conducted to establish the bioequivalence of generic formulation with that of branded reference formulation, providing confidence to clinicians to use these products interchangeably. This study was carried out to compare a locally manufactured formulation of flurbiprofen with that of a branded product. Twenty two healthy male adults received a single dose of flurbiprofen (100mg) either generic or branded product according to randomization scheme on each of 2 periods. Blood samples were collected and plasma flurbiprofen concentration was determined by a validated HPLC method. Pharmacokinetic parameters like AUC(0-t), AUC(0-oo), Cmax, Tmax, t½, Vd and clearance were determined. The 90% CI for the ratio of geometric means of test to reference product's pharmacokinetic variables was calculated. Pharmacokinetic parameters for two formulations were comparable. Ratio of means of AUC(0-24), AUC(0-oo) and Cmax for test to reference products and 90% CI for these ratios were within the acceptable range. The p-values calculated by TOST were much less than the specified value (p-0.05). ANOVA gave p-values which were more than the specified value (p-0.05) for sequence, subject, period and formulation. Test formulation of flurbiprofen (tablet Flurso) was found to meet the criteria for bioequivalence to branded product (tablet Ansaid) based on pharmacokinetic parameters.

Two-Way Regularized Fuzzy Clustering of Multiple Correspondence Analysis.

Science.gov (United States)

Kim, Sunmee; Choi, Ji Yeh; Hwang, Heungsun

2017-01-01

Multiple correspondence analysis (MCA) is a useful tool for investigating the interrelationships among dummy-coded categorical variables. MCA has been combined with clustering methods to examine whether there exist heterogeneous subclusters of a population, which exhibit cluster-level heterogeneity. These combined approaches aim to classify either observations only (one-way clustering of MCA) or both observations and variable categories (two-way clustering of MCA). The latter approach is favored because its solutions are easier to interpret by providing explicitly which subgroup of observations is associated with which subset of variable categories. Nonetheless, the two-way approach has been built on hard classification that assumes observations and/or variable categories to belong to only one cluster. To relax this assumption, we propose two-way fuzzy clustering of MCA. Specifically, we combine MCA with fuzzy k-means simultaneously to classify a subgroup of observations and a subset of variable categories into a common cluster, while allowing both observations and variable categories to belong partially to multiple clusters. Importantly, we adopt regularized fuzzy k-means, thereby enabling us to decide the degree of fuzziness in cluster memberships automatically. We evaluate the performance of the proposed approach through the analysis of simulated and real data, in comparison with existing two-way clustering approaches.

One-Particle vs. Two-Particle Crossover in Weakly Coupled Hubbard Chains and Ladders: Perturbative Renormalization Group Approach

OpenAIRE

Kishine, Jun-ichiro; Yonemitsu, Kenji

1997-01-01

Physical nature of dimensional crossovers in weakly coupled Hubbard chains and ladders has been discussed within the framework of the perturbative renormalization-group approach. The difference between these two cases originates from different universality classes which the corresponding isolated systems belong to.

Probability representations of a class of two-way diffusions

Energy Technology Data Exchange (ETDEWEB)

Clifford, P.; Green, N.J.P. [Department of Statistics, University of Oxford, Oxford (United Kingdom); Feng, J.F. [COGS, Sussex University, Brighton (United Kingdom); Wei, G. [Department of Mathematics, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong (China)

2002-07-19

There has been little progress in the analysis of two-way diffusion in the last few decades due to the difficulties brought by the interface section similar to a free boundary condition. In this paper, however, the equivalent probability model is considered and the interface section is precisely described by an integral equation. The solution of two-way diffusion is then expressed in an integral form with the integrand being the solution of a classical first passage time model and the solution of a one-dimensional integral equation which is relatively easier to solve. The exact expression of the two-way diffusion enables us to find the explicit solution of the model with infinite horizontal boundaries and without drifting. (author)

Numerical study of two disks settling in an Oldroyd-B fluid: From periodic interaction to chaining

Science.gov (United States)

Pan, Tsorng-Whay; Glowinski, Roland

2017-12-01

In this article, we present a numerical study of the dynamics of two disks sedimenting in a narrow vertical channel filled with an Oldroyd-B fluid. Two kinds of particle dynamics are observed: (i) a periodic interaction between the two disks, and (ii) the formation of a two-disk chain. For the periodic interaction of the two disks, two different motions are observed: (a) the two disks stay far apart and interact periodically, and (b) the two disks interact closely and then far apart in a periodic way, like the drafting, kissing, and tumbling of two disks sedimenting in a Newtonian fluid, due to a weak elastic force. Concerning the formation of a two-disk chain occurring at higher values of the elasticity number, either a tilted chain or a vertical chain is observed. Our simulations show that, as expected, the values of the elasticity and Mach numbers are the determining factors concerning the particle chain formation and its orientation.

Two-Way Satellite Time Transfer Between USNO and PTB

National Research Council Canada - National Science Library

Piester, D; Bauch, A; Becker, J; Polewka, T; McKinley, A; Breakiron, L; Smith, A; Fonville, B; Matsakis, D

2005-01-01

Two completely independent two-way time and frequency transfer (TWSTFT) links have been established between the institutions of USNO and PTB, with transponder frequencies in the Ku-band and X-band, respectively...

Catalytic Activity Control via Crossover between Two Different Microstructures

KAUST Repository

Zhou, Yuheng

2017-09-08

Metal nanocatalysts hold great promise for a wide range of heterogeneous catalytic reactions, while the optimization strategy of catalytic activity is largely restricted by particle size or shape control. Here, we demonstrate that a reversible microstructural control through the crossover between multiply-twinned nanoparticle (MTP) and single crystal (SC) can be readily achieved by solvent post-treatment on gold nanoparticles (AuNPs). Polar solvents (e.g. water, methanol) direct the transformation from MTP to SC accompanied by the disappearance of twinning and stacking faults. A reverse transformation from SC to MTP is achieved in non-polar solvent (e.g. toluene) mixed with thiol ligands. The transformation between two different microstructures is directly observed by in-situ TEM and leads to a drastic modulation of catalytic activity towards the gas-phase selective oxidation of alcohols. There is a quasi-linear relationship between TOFs and MTP concentrations. Based on the combined experimental and theoretical investigations of alcohol chemisorption on these nanocatalysts, we propose that the exposure of {211}-like microfacets associated with twin boundaries and stack faults accounts for the strong chemisorption of alcohol molecules on MTP AuNPs and thus the exceptionally high catalytic activity.

An exploratory, randomized, parallel-group, open-label, relative bioavailability study with an additional two-period crossover food-effect study exploring the pharmacokinetics of two novel formulations of pexmetinib (ARRY-614

Directory of Open Access Journals (Sweden)

Wollenberg LA

2015-09-01

Full Text Available Lance A Wollenberg,1 Donald T Corson,2,3 Courtney A Nugent,1 Farran L Peterson,1 Ann M Ptaszynski,1 Alisha Arrigo,2,3 Coralee G Mannila,2,3 Kevin S Litwiler,1 Stacie J Bell1,4 1Array BioPharma, Boulder, 2Array BioPharma, Longmont, CO, 3Avista Pharma Solutions, Longmont, CO, 4Mallinckrodt Pharmaceuticals, Ellicott City, MD, USA Background: Pexmetinib (ARRY-614 is a dual inhibitor of p38 mitogen-activated protein kinase and Tie2 signaling pathways implicated in the pathogenesis of myelodysplastic syndromes. Previous clinical experience in a Phase I dose-escalation study of myelodysplastic syndrome patients using pexmetinib administered as neat powder-in-capsule (PIC exhibited high variability in pharmacokinetics and excessive pill burden, prompting an effort to improve the formulation of pexmetinib. Methods: A relative bioavailability assessment encompassed three parallel treatment cohorts of unique subjects comparing the two new formulations (12 subjects per cohort, a liquid oral suspension (LOS and liquid-filled capsule (LFC and the current clinical PIC formulation (six subjects in a fasted state. The food-effect assessment was conducted as a crossover of the LOS and LFC formulations administered under fed and fasted conditions. Subjects were divided into two groups of equal size to evaluate potential period effects on the food-effect assessment. Results: The geometric mean values of the total plasma exposures based upon area-under-the-curve to the last quantifiable sample (AUClast of pexmetinib were approximately four- and twofold higher after administration of the LFC and LOS formulations, respectively, than after the PIC formulation, when the formulations were administered in the fasted state. When the LFC formulation was administered in the fed state, pexmetinib AUClast decreased by <5% compared with the fasted state. After administration of the LOS formulation in the fed state, pexmetinib AUClast was 34% greater than observed in the fasted

Decoy-state quantum key distribution with two-way classical postprocessing

International Nuclear Information System (INIS)

Ma Xiongfeng; Fung, C.-H.F.; Chen Kai; Lo, H.-K.; Dupuis, Frederic; Tamaki, Kiyoshi

2006-01-01

Decoy states have recently been proposed as a useful method for substantially improving the performance of quantum key distribution (QKD) protocols when a coherent-state source is used. Previously, data postprocessing schemes based on one-way classical communications were considered for use with decoy states. In this paper, we develop two data postprocessing schemes for the decoy-state method using two-way classical communications. Our numerical simulation (using parameters from a specific QKD experiment as an example) results show that our scheme is able to extend the maximal secure distance from 142 km (using only one-way classical communications with decoy states) to 181 km. The second scheme is able to achieve a 10% greater key generation rate in the whole regime of distances. We conclude that decoy-state QKD with two-way classical postprocessing is of practical interest

Bioequivalence of generic lamotrigine 100-mg tablets in healthy Thai male volunteers: a randomized, single-dose, two-period, two-sequence crossover study.

Science.gov (United States)

Srichaiya, Arunee; Longchoopol, Chaowanee; Oo-Puthinan, Sarawut; Sayasathid, Jarun; Sripalakit, Pattana; Viyoch, Jarupa

2008-10-01

Lamotrigine is an antiepileptic drug which has been used in the treatment of epilepsy and bipolar disorder. A search of the literature did not find previously published bioequivalence and pharmacokinetic evaluations of lamotrigine in healthy Thai male volunteers. The aim of this study was to compare the pharmacokinetic parameters between 2 brands of lamotrigine in healthy Thai male volunteers. A randomized, single-dose, 2-period, 2-sequence, crossover study design with a 2-week washout period was conducted in healthy Thai males. Subjects were randomized to receive either the test or reference formulation in the first period. All subjects were required to be nonsmokers and without a history of alcohol or drug abuse. Plasma samples were collected over a 120-hour period after 100-mg lamotrigine administration in each period. A validated high-performance liquid chromatography ultraviolet method was used to analyze lamotrigine concentration in plasma. Pharmacokinetic parameters were determined using a noncompartmental method. Bioequivalence between the test and reference products, as defined by the US Food and Drug Administration (FDA), is determined when the ratio for the 90% CIs of the difference in the means of the log-transformed AUC(0-t), AUC(0-infinity), and C(max) of the 2 products are within 0.80 and 1.25. Adverse events were determined by measuring vital signs after dosing. Subjects were also asked if they suffered from undesirable effects such as nausea, vomiting, dizziness, and headache. This bioequivalence study was performed in 24 healthy Thai males (mean [SD] age, 20.5 [1.3] years; range, 19-24 years; weight, 62.5 [7.4] kg; height, 172.8 [6.9] cm; body mass index, 20.9 [2.0] kg/m(2)). The mean (SD) C(max) and T(max) of the test formulation of lamotrigine were 1.7 (0.3) microg/mL and 1.2 (0.9) hours, respectively. The mean (SD) C(max) and T(max) of the reference formulation of lamotrigine were 1.7 (0.3) microg/mL and 1.4 (1.0) hours, respectively. The mean

Two-way visible light communication and illumination with LEDs

NARCIS (Netherlands)

Li, S.; Pandharipande, A.; Willems, F.M.J.

2017-01-01

Visible light communications (VLC) with light-emitting diodes (LEDs) has attracted applications, such as data communications, lighting control, and light interaction. In this paper, we propose a system by which two LED devices are used for two-way VLC while also providing illumination. We consider

Engineering of spatial solitons in two-period QPM structures

DEFF Research Database (Denmark)

Johansen, Steffen Kjær; Carrasco, Silvia; Torner, Lluis

2002-01-01

We report on a scheme which might make it practically possible to engineer the effective competing nonlinearities that on average govern the light propagation in quasi-phase-matching (QPM) gratings. Modulation of the QPM period with a second longer period, introduces an extra degree of freedom...... relative lengths of the two periods and we consider the effect on solitons and the bandwidth for their generation. We derive an expression for the bandwidth of multicolor soliton generation in two-period QPM samples and we predict and confirm numerically that the bandwidth is broader in the two-period QPM...

Relay Selection and Resource Allocation in One-Way and Two-Way Cognitive Relay Networks

KAUST Repository

Alsharoa, Ahmad M.

2013-01-01

In this work, the problem of relay selection and resource power allocation in one- way and two-way cognitive relay networks using half duplex channels with different relaying protocols is investigated. Optimization problems for both single

Notes on testing equality and interval estimation in Poisson frequency data under a three-treatment three-period crossover trial.

Science.gov (United States)

Lui, Kung-Jong; Chang, Kuang-Chao

2016-10-01

When the frequency of event occurrences follows a Poisson distribution, we develop procedures for testing equality of treatments and interval estimators for the ratio of mean frequencies between treatments under a three-treatment three-period crossover design. Using Monte Carlo simulations, we evaluate the performance of these test procedures and interval estimators in various situations. We note that all test procedures developed here can perform well with respect to Type I error even when the number of patients per group is moderate. We further note that the two weighted-least-squares (WLS) test procedures derived here are generally preferable to the other two commonly used test procedures in the contingency table analysis. We also demonstrate that both interval estimators based on the WLS method and interval estimators based on Mantel-Haenszel (MH) approach can perform well, and are essentially of equal precision with respect to the average length. We use a double-blind randomized three-treatment three-period crossover trial comparing salbutamol and salmeterol with a placebo with respect to the number of exacerbations of asthma to illustrate the use of these test procedures and estimators. © The Author(s) 2014.

Catalytic Activity Control via Crossover between Two Different Microstructures

KAUST Repository

Zhou, Yuheng; Zhu, Yihan; Wang, Zhi-Qiang; Zou, Shihui; Ma, Guicen; Xia, Ming; Kong, Xueqian; Xiao, Liping; Gong, Xue-Qing; Fan, Jie

2017-01-01

microstructural control through the crossover between multiply-twinned nanoparticle (MTP) and single crystal (SC) can be readily achieved by solvent post-treatment on gold nanoparticles (AuNPs). Polar solvents (e.g. water, methanol) direct the transformation from

Bioavailability of two single-dose oral formulations of omeprazole 20 mg: an open-label, randomized sequence, two-period crossover comparison in healthy Mexican adult volunteers.

Science.gov (United States)

Poo, Jorge Luis; Galán, Juan Francisco; Rosete, Alejandra; de Lago, Alberto; Oliva, Iván; González-de la Parra, Mario; Jiménez, Patricia; Burke-Fraga, Victoria; Namur, Salvador

2008-04-01

Omeprazole is a proton-pump inhibitor that acts to reduce acid secretion in the stomach and is used for treating various acid-related gastrointestinal disorders. There are several generic formulations of omeprazole available in Mexico; however, a literature search failed to identify published data concerning the bioavailability of these formulations in the Mexican population. The aim of this study was to compare the bioavailability of 2 oral formulations of omeprazole 20-mg capsules, marketed for use in Mexico, in healthy volunteers: Inhibitron (test formulation) and LosecA 20 mg (reference formulation). This study used a single-dose, open-label, randomized sequence, 2 x 2 crossover (2 administration periods x 2 treatments) design to compare the 2 formulations. Eligible subjects were healthy adult Mexican volunteers of both sexes. Subjects were randomly assigned in a 1:1 ratio to receive a single 20-mg dose of the test formulation followed by the reference formulation, or vice versa, with a 7-day washout period between administration periods. After a 12-hour (overnight) fast, subjects received a single, 20-mg dose of the corresponding formulation. Plasma samples were obtained over a 12-hour period after administration. Plasma omeprazole concentrations were analyzed by a nonstereospecific high-performance liquid chromatography method. For analysis of pharmacokinetic properties, including C(max), AUC from time 0 (baseline) to time t (AUC(0-t)), and AUC from baseline to infinity (AUC(0-infinity)), blood samples were drawn at baseline and 0.17, 0.33, 0.50, 0.75, 1, 1.25, 1.50, 1.75, 2, 2.50, 3, 4, 6, 8, and 12 hours after administration. The formulations were considered bioequivalent if the natural log (ln)-transformed ratios of C(max) and AUC were within the predetermined equivalence range of 80% to 125%, and if P disability, or required intervention to prevent permanent impairment or damage. Thirty-four subjects were enrolled and completed the study (25 men and 9

Testing equality and interval estimation in binary responses when high dose cannot be used first under a three-period crossover design.

Science.gov (United States)

Lui, Kung-Jong; Chang, Kuang-Chao

2015-01-01

When comparing two doses of a new drug with a placebo, we may consider using a crossover design subject to the condition that the high dose cannot be administered before the low dose. Under a random-effects logistic regression model, we focus our attention on dichotomous responses when the high dose cannot be used first under a three-period crossover trial. We derive asymptotic test procedures for testing equality between treatments. We further derive interval estimators to assess the magnitude of the relative treatment effects. We employ Monte Carlo simulation to evaluate the performance of these test procedures and interval estimators in a variety of situations. We use the data taken as a part of trial comparing two different doses of an analgesic with a placebo for the relief of primary dysmenorrhea to illustrate the use of the proposed test procedures and estimators.

A two-way regularization method for MEG source reconstruction

KAUST Repository

Tian, Tian Siva; Huang, Jianhua Z.; Shen, Haipeng; Li, Zhimin

2012-01-01

The MEG inverse problem refers to the reconstruction of the neural activity of the brain from magnetoencephalography (MEG) measurements. We propose a two-way regularization (TWR) method to solve the MEG inverse problem under the assumptions that only a small number of locations in space are responsible for the measured signals (focality), and each source time course is smooth in time (smoothness). The focality and smoothness of the reconstructed signals are ensured respectively by imposing a sparsity-inducing penalty and a roughness penalty in the data fitting criterion. A two-stage algorithm is developed for fast computation, where a raw estimate of the source time course is obtained in the first stage and then refined in the second stage by the two-way regularization. The proposed method is shown to be effective on both synthetic and real-world examples. © Institute of Mathematical Statistics, 2012.

A two-way regularization method for MEG source reconstruction

KAUST Repository

Tian, Tian Siva

2012-09-01

The MEG inverse problem refers to the reconstruction of the neural activity of the brain from magnetoencephalography (MEG) measurements. We propose a two-way regularization (TWR) method to solve the MEG inverse problem under the assumptions that only a small number of locations in space are responsible for the measured signals (focality), and each source time course is smooth in time (smoothness). The focality and smoothness of the reconstructed signals are ensured respectively by imposing a sparsity-inducing penalty and a roughness penalty in the data fitting criterion. A two-stage algorithm is developed for fast computation, where a raw estimate of the source time course is obtained in the first stage and then refined in the second stage by the two-way regularization. The proposed method is shown to be effective on both synthetic and real-world examples. © Institute of Mathematical Statistics, 2012.

The Multicultural Science Framework: Research on Innovative Two-Way Immersion Science Classrooms.

Science.gov (United States)

Hadi-Tabassum, Samina

2000-01-01

Reviews the different approaches to multicultural science teaching that have emerged in the past decade, focusing on the Spanish-English two-way immersion classroom, which meets the needs of Spanish speakers learning English and introduces students to the idea of collaboration across languages and cultures. Two urban two-way immersion classrooms…

Two-way quantum key distribution at telecommunication wavelength

International Nuclear Information System (INIS)

Kumar, Rupesh; Lucamarini, Marco; Di Giuseppe, Giovanni; Natali, Riccardo; Mancini, Giorgio; Tombesi, Paolo

2008-01-01

We report on a quantum key distribution effected with a two-way deterministic protocol over a standard telecommunication fiber. Despite the common belief of a prohibitive loss rate for such a scheme, our results show its feasibility on distances of few tenths of kilometers

Two-way and three-way approaches to ultra high performance liquid chromatography-photodiode array dataset for the quantitative resolution of a two-component mixture containing ciprofloxacin and ornidazole.

Science.gov (United States)

Dinç, Erdal; Ertekin, Zehra Ceren; Büker, Eda

2016-09-01

Two-way and three-way calibration models were applied to ultra high performance liquid chromatography with photodiode array data with coeluted peaks in the same wavelength and time regions for the simultaneous quantitation of ciprofloxacin and ornidazole in tablets. The chromatographic data cube (tensor) was obtained by recording chromatographic spectra of the standard and sample solutions containing ciprofloxacin and ornidazole with sulfadiazine as an internal standard as a function of time and wavelength. Parallel factor analysis and trilinear partial least squares were used as three-way calibrations for the decomposition of the tensor, whereas three-way unfolded partial least squares was applied as a two-way calibration to the unfolded dataset obtained from the data array of ultra high performance liquid chromatography with photodiode array detection. The validity and ability of two-way and three-way analysis methods were tested by analyzing validation samples: synthetic mixture, interday and intraday samples, and standard addition samples. Results obtained from two-way and three-way calibrations were compared to those provided by traditional ultra high performance liquid chromatography. The proposed methods, parallel factor analysis, trilinear partial least squares, unfolded partial least squares, and traditional ultra high performance liquid chromatography were successfully applied to the quantitative estimation of the solid dosage form containing ciprofloxacin and ornidazole. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Two-stage crossover from thermal to quantum flux creep of dilute vortex ensembles in various high-T{sub c} superconducting thin films

Energy Technology Data Exchange (ETDEWEB)

Akerman, Johan J.; Venturini, E. L.; Siegal, M. P.; Yun, S. H.; Karlsson, U. O.; Rao, K. V.

2001-09-01

The thermal-to-quantum flux creep crossover at low vortex densities has been studied in YBa{sub 2}Cu{sub 3}O{sub 7}, TlBa{sub 2}CaCu{sub 2}O{sub 7-{delta}}, and HgBa{sub 2}CaCu{sub 2}O{sub 6+{delta}} thin films using ac susceptibility. The crossover temperatures T{sub cr} are 10--11, 17, and 30 K, respectively. Both thermal and quantum flux creep is suppressed as the vortex density is decreased. We observe a two-stage nature in the crossover behavior which appears to be a general property of all the three materials studied.

The crossover from collective motion to periphery diffusion for two-dimensional adatom-islands on Cu(111)

International Nuclear Information System (INIS)

Karim, Altaf; Kara, Abdelkader; Rahman, Talat S; Trushin, Oleg

2011-01-01

The diffusion of two-dimensional adatom-islands (up to 100 atoms) on Cu(111) has been studied, using the self-learning kinetic Monte Carlo method (Trushin et al 2005 Phys. Rev. B 72 115401). A variety of multiple- and single-atom processes are revealed in the simulations, and the size dependences of the diffusion coefficients and effective diffusion barriers are calculated for each. From the tabulated frequencies of events found in the simulation, we show a crossover from diffusion due to the collective motion of the island to a regime in which the island diffuses through periphery-dominated mass transport. This crossover occurs for island sizes between 13 and 19 atoms. For islands containing 19-100 atoms the scaling exponent is 1.5, which is in good agreement with previous work. The diffusion of islands containing 2-13 atoms can be explained primarily on the basis of a linear increase of the barrier for the collective motion with the size of the island. (fast track communication)

Two-way text messaging: an interactive mobile learning environment in higher education

OpenAIRE

Premadasa, H. K. Salinda; Meegama, R. G. N.

2016-01-01

Short messaging service (SMS) is perhaps the most popular mobile technology prevalent among students in higher education due to its ubiquitous nature and the capability of two-way communication. However, a major limitation in two-way text messaging is sending back a part of received data with the reply message. This limitation results in users of a mobile learning environment being unable to reply back to the correct destination. This article presents a two-way text messaging system that can ...

Effect of a timebase mismatch in two-way optical frequency transfer

Science.gov (United States)

Tampellini, Anna; Clivati, Cecilia; Levi, Filippo; Mura, Alberto; Calonico, Davide

2017-12-01

Two-way frequency transfer on optical fibers is a powerful technique for the comparison of distant clocks over long and ultra-long hauls. In contrast to traditional Doppler noise cancellation, it is capable of sustaining higher link attenuation, mitigating the need of optical amplification and regeneration and thus reducing the setup complexity. We investigate the ultimate limitations of the two-way approach on a 300 km multiplexed fiber haul, considering fully independent setups and acquisition systems at the two link ends. We derive a theoretical model to predict the performance deterioration due to a bad synchronisation of the measurements, which is confirmed by experimental results. This study demonstrates that two-way optical frequency transfer is a reliable and performing technique, capable of sustaining remote clocks comparisons at the 10-19 resolution, and is relevant for the development of a fiber network of continental scale for frequency metrology in Europe.

Optimal design of work zone median crossovers.

Science.gov (United States)

2010-09-01

The use of temporary median crossovers in work zones allows for the closure of one side of a multi-lane roadway while : maintaining two-way traffic on the opposite side. This process provides the ability for construction and maintenance crews : to co...

Distributed cognitive two-way relay beamformer designs under perfect and imperfect CSI

KAUST Repository

Pandarakkottilil, Ubaidulla; Aissa, Sonia

2011-01-01

In this paper, we present distributed two-way relay beamformer designs for a cognitive radio network (CRN) in which a pair of cognitive (or secondary) transceiver nodes communicate with each other assisted by a set of cognitive two-way relay nodes

Two-way shape memory effect induced by repetitive compressive loading cycles

International Nuclear Information System (INIS)

Kim, Hyun-Chul; Yoo, Young-Ik; Lee, Jung-Ju

2009-01-01

The NiTi alloy can be trained by repetitive loading or heating cycles. As a result of the training, a two-way shape memory effect (TWSME) can be induced. Considerable research has been reported regarding the TWSME trained by tensile loading. However, the TWSME trained by compressive loading has not been investigated nearly as much. In this paper, the TWSME is induced by compressive loading cycles and the two-way shape memory strain is evaluated by using two types of specimen: a solid cylinder type and a tube type. The TWSME trained by compressive loading is different from that trained by tensile loading owing to the severe tension/compression asymmetry as described in previous research. After repetitive compressive loading cycles, strain variation upon cooling is observed, and this result proves that the TWSME is induced by compressive loading cycles. By performing compressive loading cycles, plastic deformation in NiTi alloy occurs more than for tensile loading cycles, which brings about the appearance of TWSME. It can be said that the TWSME is induced by compressive loading cycles more easily. The two-way shape memory strain increases linearly as the maximum strain of compressive loading cycles increases, regardless of the shape and the size of the NiTi alloy; this two-way shape memory strain then shows a tendency towards saturation after some repeated cycles

The impact of nurse-driven targeted HIV screening in 8 emergency departments: study protocol for the DICI-VIH cluster-randomized two-period crossover trial.

Science.gov (United States)

Leblanc, Judith; Rousseau, Alexandra; Hejblum, Gilles; Durand-Zaleski, Isabelle; de Truchis, Pierre; Lert, France; Costagliola, Dominique; Simon, Tabassome; Crémieux, Anne-Claude

2016-02-01

In 2010, to reduce late HIV diagnosis, the French national health agency endorsed non-targeted HIV screening in health care settings. Despite these recommendations, non-targeted screening has not been implemented and only physician-directed diagnostic testing is currently performed. A survey conducted in 2010 in 29 French Emergency Departments (EDs) showed that non-targeted nurse-driven screening was feasible though only a few new HIV diagnoses were identified, predominantly among high-risk groups. A strategy targeting high-risk groups combined with current practice could be shown to be feasible, more efficient and cost-effective than current practice alone. DICI-VIH (acronym for nurse-driven targeted HIV screening) is a multicentre, cluster-randomized, two-period crossover trial. The primary objective is to compare the effectiveness of 2 strategies for diagnosing HIV among adult patients visiting EDs: nurse-driven targeted HIV screening combined with current practice (physician-directed diagnostic testing) versus current practice alone. Main secondary objectives are to compare access to specialist consultation and how early HIV diagnosis occurs in the course of the disease between the 2 groups, and to evaluate the implementation, acceptability and cost-effectiveness of nurse-driven targeted screening. The 2 strategies take place during 2 randomly assigned periods in 8 EDs of metropolitan Paris, where 42 % of France's new HIV patients are diagnosed every year. All patients aged 18 to 64, not presenting secondary to HIV exposure are included. During the intervention period, patients are invited to fill a 7-item questionnaire (country of birth, sexual partners and injection drug use) in order to select individuals who are offered a rapid test. If the rapid test is reactive, a follow-up visit with an infectious disease specialist is scheduled within 72 h. Assuming an 80 % statistical power and a 5 % type 1 error, with 1.04 and 3.38 new diagnoses per 10,000 patients in

Overlay cognitive radio systems with adaptive two-way relaying

KAUST Repository

Hyadi, Amal

2013-12-01

In this paper, we propose a spectrum sharing mechanism with a two-phase two-way relaying protocol for an overlay cognitive network. The system comprises two primary users (PUs) and two secondary users (SUs). One of the SUs acts as a relay for the PUs and gains spectrum sharing as long as he respects outage probability constraints of the primary system. Moreover, we consider that the relaying node performs an optimal power allocation scheme that minimizes the outage performance of the secondary receiver. Closed form expressions for the outage probability are derived for the cases of Decode-and-Forward (DF), Amplify-and-Forward (AF), and adaptive relaying. Numerical simulations are presented to illustrate and compare the obtained results. © 2013 IEEE.

Diffraction patterns in Fresnel approximation of periodic objects for a colorimeter of two apertures

Science.gov (United States)

Cortes-Reynoso, Jose-German R.; Suarez-Romero, Jose G.; Hurtado-Ramos, Juan B.; Tepichin-Rodriguez, Eduardo; Solorio-Leyva, Juan Carlos

2004-10-01

In this work, we present a study of Fresnel diffraction of periodic structures in an optical system of two apertures. This system of two apertures was used successfully for measuring color in textile samples solving the problems of illumination and directionality that present current commercial equipments. However, the system is sensible to the spatial frequency of the periodic sample"s area enclosed in its optical field of view. The study of Fresnel diffraction allows us to establish criteria for geometrical parameters of measurements in order to assure invariance in angular rotations and spatial positions. In this work, we use the theory of partial coherence to calculate the diffraction through two continuous apertures. In the calculation process, we use the concept of point-spread function of the system for partial coherence, in this way we avoid complicated statistical processes commonly used in the partial coherence theory.

Two-Way Multi-Antenna Relaying with Simultaneous Wireless Information and Power Transfer

Directory of Open Access Journals (Sweden)

Thanaphat Srivantana

2017-03-01

Full Text Available In this paper, we propose various kinds of two-way multi-antenna relaying with simultaneous wireless information and power transfer (SWIPT and investigate their performance. Specifically, we first consider a two-way relay network where two single-antenna end nodes communicate with each other through a multi-antenna relay node that is energy constrained. This relay node harvests energy from the two end nodes and use the harvested energy for forwarding their information. Six relaying schemes that support the considered network then build on the power splitting-based relaying and time switching-based relaying protocols. The average bit error rates of these schemes are evaluated and compared by computer simulations considering several network parameters, including the number of relay antennas, power splitting ratio, and energy harvesting time. Such evaluation and comparison provide useful insights into the performance of SWIPT-based two-way multi-antenna relaying.

Outage Analysis and Optimization of SWIPT in Network-Coded Two-Way Relay Networks

Directory of Open Access Journals (Sweden)

Ruihong Jiang

2017-01-01

Full Text Available This paper investigates the outage performance of simultaneous wireless information and power transfer (SWIPT in network-coded two-way relay systems, where a relay first harvests energy from the signals transmitted by two sources and then uses the harvested energy to forward the received information to the two sources. We consider two transmission protocols, power splitting two-way relay (PS-TWR and time switching two-way relay (TS-TWR protocols. We present two explicit expressions for the system outage probability of the two protocols and further derive approximate expressions for them in high and low SNR cases. To explore the system performance limits, two optimization problems are formulated to minimize the system outage probability. Since the problems are nonconvex and have no known solution methods, a genetic algorithm- (GA- based algorithm is designed. Numerical and simulation results validate our theoretical analysis. It is shown that, by jointly optimizing the time assignment and SWIPT receiver parameters, a great performance gain can be achieved for both PS-TWR and TS-TWR. Moreover, the optimized PS-TWR always outperforms the optimized TS-TWR in terms of outage performance. Additionally, the effects of parameters including relay location and transmit powers are also discussed, which provide some insights for the SWIPT-enabled two-way relay networks.

Two-way against one-way nesting for climate downscaling in Europe and the Mediterranean region using LMDZ4

Science.gov (United States)

Li, Shan; Li, Laurent; Le Treut, Hervé

2016-04-01

In the 21st century, the estimated surface temperature warming projected by General Circulation Models (GCMs) is between 0.3 and 4.8 °C, depending on the scenario considered. GCMs exhibit a good representation of climate on a global scale, but they are not able to reproduce regional climate processes with the same level of accuracy. Society and policymakers need model projections to define climate change adaptation and mitigation policies on a global, regional and local scale. Climate downscaling is mostly conducted with a regional model nested into the outputs of a global model. This one-way nesting approach is generally used in the climate community without feedbacks from Regional Climate Models (RCMs) to GCMs. This lack of interaction between the two models may affect regional modes of variability, in particular those with a boundary conflict. The objective of this study is to evaluate a two-way nesting configuration that makes an interactive coupling between the RCM and the GCM, an approach against the traditional configuration of one-way nesting system. An additional aim of this work is to examine if the two-way nesting system can improve the RCM performance. The atmospheric component of the IPSL integrated climate model (LMDZ) is configured at both regional (LMDZ-regional) and global (LMDZ-global) scales. The two models have the same configuration for the dynamical framework and the physical forcings. The climatology values of sea surface temperature (SST) are prescribed for the two models. The stretched-grid of LMDZ-global is applied to a region defined by Europe, the Mediterranean, North Africa and Western North Atlantic. To ensure a good statistical significance of results, all simulations last at least 80 years. The nesting process of models is performed by a relaxation procedure of a time scale of 90 minutes. In the case of two-way nesting, the exchange between the two models is every two hours. The relaxation procedure induces a boundary conflict

Crossover dynamics of dispersive shocks in Bose-Einstein condensates characterized by two- and three-body interactions

KAUST Repository

Crosta, M.; Trillo, S.; Fratalocchi, Andrea

2012-01-01

We show that the perturbative nonlinearity associated with three-atom interactions, competing with standard two-body repulsive interactions, can change dramatically the evolution of one-dimensional (1D) dispersive shock waves in a Bose-Einstein condensate. In particular, we prove the existence of a rich crossover dynamics, ranging from the formation of multiple shocks regularized by nonlinear oscillations culminating in coexisting dark and antidark matter waves to 1D-soliton collapse. For a given scattering length, all these different regimes can be accessed by varying the density of atoms in the condensate.

Crossover dynamics of dispersive shocks in Bose-Einstein condensates characterized by two- and three-body interactions

KAUST Repository

Crosta, M.

2012-04-10

We show that the perturbative nonlinearity associated with three-atom interactions, competing with standard two-body repulsive interactions, can change dramatically the evolution of one-dimensional (1D) dispersive shock waves in a Bose-Einstein condensate. In particular, we prove the existence of a rich crossover dynamics, ranging from the formation of multiple shocks regularized by nonlinear oscillations culminating in coexisting dark and antidark matter waves to 1D-soliton collapse. For a given scattering length, all these different regimes can be accessed by varying the density of atoms in the condensate.

Two-way CSI-assisted AF relaying with HPA nonlinearity

KAUST Repository

Qi, Jian; Aissa, Sonia; Alouiniz, Mohamed-Slim

2015-01-01

In this paper, we investigate half-duplex two-way dual-hop channel state information (CSI)-assisted amplify-andforward (AF) relaying in the presence of high-power amplifier (HPA) nonlinearity at relays. The expression for the end-toend signal

[Vaginitis and vaginosis. Comparison of two periods].

Science.gov (United States)

Ceruti, M; Canestrelli, M; Piantelli, G; Amone, F; Condemi, V; De Paolis, P; Ludovici, G; Somenzi, P

1993-10-01

Vaginitis is the most frequent gynecological disease. It is characterized by objective and subjective signs of inflammation and differs from bacterial vaginosis (BV) which is an abnormal condition of the vaginal ecosystem caused by the excessive growth of aerobic and anaerobic flora normally present in the vagina with an increased risk of pelvic inflammatory disease (PID). The authors report the results of a study carried out at the Centre for Gynecological Infections at the Clinic of Obstetrics and Gynecology of the University of Parma. 828 patients were enrolled in the study during the period 1985-86 and 1559 patients during the two-year period 1991-92. The aim of the study was to evaluate variations in epidemiological data for vaginitis and bacterial vaginosis in the two periods examined. No significant changes were observed (p > 0.05) with regard to the prevalence of Ca, Tv and BV forms. On the other hand, there was a significant reduction (p vaginitis and BV showed a reduction of other microorganisms and an increase in negative vaginal swabs in adults (> 20 years old).

A prospective, double-blind, randomized, two-period crossover, multicenter study to evaluate tolerability and patient preference between mirabegron and tolterodine in patients with overactive bladder (PREFER study).

Science.gov (United States)

Staskin, David; Herschorn, Sender; Fialkov, Jonathan; Tu, Le Mai; Walsh, Terry; Schermer, Carol R

2018-02-01

The objective of this study was to assess the tolerability and treatment preference in patients with overactive bladder (OAB) treated with mirabegron or tolterodine. This was a two-period, 8-week crossover, double-blind, phase IV study (PREFER; NCT02138747) in treatment-naive adults with OAB for 3 months or longer randomized to one of four treatment sequences in a 5:5:1:1 ratio (mirabegron/tolterodine, tolterodine/mirabegron, mirabegron/mirabegron, or tolterodine/tolterodine), separated by a washout period of 2 weeks. The primary endpoint was drug tolerability using the Medication Tolerability scale of the OAB Treatment Satisfaction (OAB-S) questionnaire at end of treatment (EoT). Period-by-treatment interactions were analyzed to determine any effect of drug order. Patient preference, change from baseline in OAB symptoms, and treatment-emergent adverse events (TEAEs) were assessed. A total of 358 randomized patients completed the OAB-S Medication Tolerability scale questionnaire at one or more visits after the baseline evaluation. The mean (95% CI) OAB-S Medication Tolerability scores were significantly higher (better tolerability) for mirabegron (86.29 [83.50, 89.08]) than for tolterodine (83.40 [80.59, 86.20]; p = 0.004). The period-by-treatment interaction was not significant (p = 0.955). Improvements in OAB-S Medication Tolerability scores at EoT were more evident in women, patients aged ≥65 years, and in patients without baseline incontinence, and were greater with mirabegron than with tolterodine extended release. There were no significant differences in patient preference or improvements in OAB symptoms. Significant differences in favor of mirabegron were observed for anticholinergic TEAEs (20.4% vs. 27.4%; p = 0.042) and specifically for gastrointestinal disorders (14.7% vs. 22.5%; p = 0.015). Tolerability of mirabegron was significantly higher than that of tolterodine, and patient preference and improvements in OAB symptoms were comparable

Experimental Validation of Methanol Crossover in a Three-dimensional, Two-Fluid Model of a Direct Methanol Fuel Cell

DEFF Research Database (Denmark)

Olesen, Anders Christian; Berning, Torsten; Kær, Søren Knudsen

2012-01-01

A fully coupled three-dimensional, steady-state, two-fluid, multi-component and non-isothermal DMFC model has been developed in the commercial CFD package CFX 13 (ANSYS inc.). It accounts for the presence of micro porous layers, non-equilibrium phase change, and methanol and water uptake...... in the ionomer phase of the catalytic layer, and detailed membrane transport of methanol and water. In order to verify the models ability to predict methanol crossover, simulation results are compared with experimental measurements under different current densities along with air and methanol stoichiometries....... Methanol crossover is indirectly measured based on the combined anode and cathode exhaust CO2 mole fraction and by accounting for the CO2 production at the anode as a function of current density. This approach is simple and assumes that all crossed over methanol is oxidized. Moreover, it takes CO2...

Improvement of two-way continuous variable quantum cryptography by using additional noise

International Nuclear Information System (INIS)

Wang Minjie; Pan Wei

2010-01-01

The performance of quantum key distribution such as one-way continuous variable protocols, can be increased by adding some noise on the reference side of error correction in the error-correction phase. For this reason, we here study this possibility in the case of two-way continuous variable system. Finally, the numerical results show that the using of additional noise gives two-way schemes better security performance in terms of secret key rates and resistance to channel excess noise.

Two-Way Text Messaging: An Interactive Mobile Learning Environment in Higher Education

Science.gov (United States)

Premadasa, H. K. Salinda; Meegama, R. G. N.

2016-01-01

Short messaging service (SMS) is perhaps the most popular mobile technology prevalent among students in higher education due to its ubiquitous nature and the capability of two-way communication. However, a major limitation in two-way text messaging is sending back a part of received data with the reply message. This limitation results in users of…

Two-Way Outsourcing, International Migration, and Wage Inequality

OpenAIRE

Morihiro Yomogida; Laixun Zhao

2009-01-01

This paper develops a general equilibrium model with a vertical production structure to examine the relationship between offshore outsourcing and international migration,especially emphasizing their effects on the wages of skilled and unskilled workers. Two-way outsourcing (simultaneous insourcing and outsourcing) in skilled-labor intensive services arises due to product differentiation and scale economies, and outsourcing in unskilled-labor intensive processing occurs because of factor endow...

Bioequivalence and pharmacokinetic evaluation of two formulations of risperidone 2 mg : an open-label, single-dose, fasting, randomized-sequence, two-way crossover study in healthy male Chinese volunteers.

Science.gov (United States)

Liu, Yun; Zhang, Meng-qi; Jia, Jing-ying; Liu, Yan-mei; Liu, Gang-yi; Li, Shui-jun; Wang, Wei; Weng, Li-ping; Yu, Chen

2013-03-01

Risperidone is a benzisoxazole derivate and is effective in the treatment of schizophrenia and other psychiatric illnesses in adults and children. Although there are a few reports in the literature regarding the pharmacokinetic characteristics of risperidone, insufficient data on its pharmacokinetic properties in a Chinese population are available. To meet the requirements for marketing a new generic product, this study was designed to compare the pharmacokinetic properties and bioequivalence of two 2 mg tablet formulations of risperidone: a newly developed generic formulation (test) and a branded formulation (reference) in healthy adult male Chinese volunteers. A single-dose, open-label, randomized-sequence, 2 × 2 crossover study was conducted in fasted healthy male Chinese volunteers. Eligible participants were randomly assigned in a 1:1 ratio to receive 1 tablet (2 mg each) of the test formulation (Risperidone tablet; Dr. Reddy's Laboratories Ltd., Hyderabad, India) or the reference formulation (Risperdal(®) tablet; Xian-Janssen Pharmaceutical Ltd., Xi-an, China), followed by a 2-week washout period and subsequent administration of the alternate formulation. The study drugs were administered after a 10-hour overnight fast. Plasma samples were collected over 96 hours. Plasma concentrations of the parent drug, risperidone, and its active metabolite, 9-hydroxy-risperidone, were analyzed by a liquid chromatography-tandem mass spectrometry method. The formulations would be considered bioequivalent if the 90% confidence intervals (CIs) of the natural log-transformed values were within the predetermined 80-125% equivalence range for the maximum plasma drug concentration (Cmax) and the area under the plasma concentration-time curve (AUC), in accordance with guidelines issued by the US Food and Drug Administration. Assessment of tolerability was based on recording of adverse events (AEs), monitoring of vital signs, electrocardiograms, and laboratory tests at baseline

Two Fundamental Problems and Two Periods of German Speculative Idealism

Directory of Open Access Journals (Sweden)

V. ZOLOTUKHIN

2015-02-01

Full Text Available The author’s concerns are with the philosophical and theological problems integral to German Speculative Idealism. Two key ideas permeated the whole of German Idealism: the idea of divine self-realization / self-understanding and the idea of gravitating between the poles of theism and pantheism. The author attempts to explain how these two ideas are related throughout the course of German Idealism. He includes in this study not only Fichte /the elder/, Schelling, and Hegel, but also the so-called speculative theists (Fichte /the younger/ and others, whose thought in both ideology and methodology resembles that of Schelling and Hegel. The author demonstrates using the writings of the philosophers that the two ideas may be related though the concept of creativity . If God realizes himself in the world and through the world, then it makes sense to say that philosophical theology is replete with pantheism. But if the divine realization takes place ontologically before the process of creation and is in itself an act which takes place within the divine Being Himself, the process is then clearly theistic. Idealists of the older school do not link creation with the Absolute - they reject this point or they speak about creation in reference to the act of divine self-realization. Idealists of the younger generation, on the contrary, hold that the act of divine self-realization precedes that of creation. The author opines that it is this point which allows us to diff erentiate between a philosophical system which leans towards pantheism from one which tends toward theism. The older idealists were indeed mostly pantheists, while the younger generation was mostly theistic. In view of this, German Idealism may be considered to be divided into two periods

Electric crossover

International Nuclear Information System (INIS)

Schuster, R.M.; Luria, N.G.

1977-01-01

This invention concerns an electric crossover that makes a steam and pressure-tight seal for a conductor crossing two separate walls of a nuclear reactor vessel that seismic tremors or thermal expansion of the walls and conductor subject to relative displacements. The conductors, that have to cross the vessels, are fixed to the walls of the vessel in crossover systems fitted in crossover channels made in the walls of the vessel on their initial manufacture. The separate walls of the vessel move independently when they undergo an earth tremor or a temperature change between the walls or between the conductor. This shift can damage the conductor or the crossover system and this could give rise to cause steam or other materials to leak in the reactor should leaks occur in the primary system. Furthermore, in the case of medium or high power conductors, which are relatively rigid, the non-alignment of the crossover channels can bring about awkward stresses in the conductors or their protective sheathing. The aims of this invention are fulfilled by designing an electric crossover to pass at least one conductor through the two separate walls of a vessels, that includes an initial sub-assembly crossover, secured in a leak-tight manner to the first wall and a second sub-sessembly crossover in sliding or rolling contact with the second wall, whilst forming a leak-tight seal with it [fr

Periodic trajectories for two-dimensional nonintegrable Hamiltonians

International Nuclear Information System (INIS)

Davies, K.T.R.

1990-02-01

I want to report on some calculations of classical periodic trajectories in a two-dimensional nonintegrable potential. After a brief introduction, I will present some details of the theory. The main part of this report will be devoted to showing pictures of the various families of trajectories and to discussing the topology (in E-τ space) and branching behavior of these families. Then I will demonstrate the connection between periodic trajectories and ''nearby'' nonperiodic trajectories, which nicely illustrates the relationship of this work to chaos. Finally, I will discuss very briefly how periodic trajectories can be used to calculate tori. 12 refs., 40 figs

Second-order two-scale method for bending behaviors of composite plate with periodic configuration

International Nuclear Information System (INIS)

Zhu Guoqing; Cui Junzhi

2010-01-01

In this paper, the second-order two-scale analysis method for bending behaviors of the plate made from composites with 3-D periodic configuration is presented by means of construction way. It can capture the microscopic 3-D mechanics behaviors caused from 3-D micro-structures. First, directly starting from the 3-D elastic plate model of composite materials with 3-D periodic configuration, three cell models are defined, and correspondingly the three classes of cell functions only defined on 3 normalized cells are constructed. And then, the effective homogenization parameters of composites are calculated from those local functions, it leads to a 2-D homogenized laminar plate problem. Next, to solve it the homogenization solution is obtained. Finally, the second-order two-scale solution is constructed from the micro-cell functions and the homogenization solution.

78 FR 31576 - Enforcement Proceeding; Certain Two-Way Global Satellite Communication Devices, System and...

Science.gov (United States)

2013-05-24

...-Way Global Satellite Communication Devices, System and Components Thereof; Notice of Institution of... importation of certain two-way global satellite communication devices, system and components thereof by reason... importation any two-way global satellite communication devices, system, and components thereof that infringe...

Technology transfer, a two-way street

International Nuclear Information System (INIS)

Martin, H.L.

1994-01-01

Technology transfer through the Pollution Prevention ampersand Control Conferences, which have been cosponsored by the Environmental Protection Agency and by the professional societies of industry, greatly improved the environmental projects of the Department of Energy at Savannah River Site (SRS) in the mid-1980's. Those technologies, used in the liquid effluent treatment of the metal finishing liquid effluents from aluminum cleaning and nickel plating of fuel and targets for the nuclear production reactors, have been enhanced by the research and development of SRS engineers and scientists. The technology transfer has now become a two-way street to the benefit of our Nation's environment as these enhancements are being adopted in the metal finishing industry. These success stories are examples of the achievements anticipated in the 1990's as technology development in the federal facilities is shared with commercial industry

Bioequivalence of two film-coated tablets of imatinib mesylate 400 mg: a randomized, open-label, single-dose, fasting, two-period, two-sequence crossover comparison in healthy male South American volunteers.

Science.gov (United States)

Parrillo-Campiglia, Susana; Ercoli, Mónica Cedres; Umpierrez, Ofelia; Rodríguez, Patricia; Márquez, Sara; Guarneri, Carolina; Estevez-Parrillo, Francisco T; Laurenz, Marilena; Estevez-Carrizo, Francisco E

2009-10-01

Imatinib is a tyrosine kinase inhibitor that has been established as a highly effective therapy for chronic myelogenous leukemia and gastrointestinal stromal tumors. A new generic, once-daily 400-mg tablet of imatinib has been developed by a pharmaceutical company in Argentina, where the regulatory standard for marketing authorization of an imatinib generic is in vitro dissolution testing. The aim of this study was to assess the bioequivalence of a new generic film-coated test tablet formulation versus a film-coated reference tablet formulation of imatinib 400 mg. The local manufacturer seeks to validate the in vitro performance of this new formulation with a bioequivalence study. A randomized, open-label, single-dose, fasting, 2-period, 2-sequence crossover design with a 2-week washout period was used in this study. The study population consisted of healthy male South American (Uruguayan) volunteers, who were assigned in a 1:1 ratio to a randomized sequence (test-reference or reference-test). In each period, the test or reference formulation was administered after an overnight fast. During the 72-hour follow-up period, participants were monitored for vital signs and symptoms. Blood samples were collected at 15 time points, including baseline, until 72 hours. Physical examination and laboratory tests (blood, urine) were repeated 1 week after study completion. A noncompartmental model was used to determine the pharmacokinetic parameters of imatinib. The 90% CIs of the test/reference ratios for AUC(0-infinity) and C(max) were determined; the test and reference formulations were considered bioequivalent if the 90% CIs were between 0.80 and 1.25. Adverse events were assessed by a nurse who administered a questionnaire while the healthy volunteers were admitted in the unit. The bioequivalence study was conducted in 30 Uruguayan male volunteers. Demographic characteristics (mean [SD]) included age, 27.8 (6.5) years; weight, 71.2 (9.8) kg; height, 1.71 (0.09) m; and body

Sum-Rate Optimization in a Two-Way Relay Network with Buffering

DEFF Research Database (Denmark)

Liu, Huaping; Popovski, Petar; De Carvalho, Elisabeth

2013-01-01

A Relay Station (RS) uses a buffer to store and process the received data packets before forwarding them. Recently, the buffer has been exploited in one-way relaying to opportunistically schedule the two different links according to their channel quality. The intuition is that, if the channel...... to the destination is poor, then RS stores more data from the source, in order to use it when the channel to the destination is good. We apply this intuition to the case of half-duplex two-way relaying, where the interactions among the buffers and links become more complex. We investigate the sum-rate maximization...

Two-way communication promote value-added services

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-06-01

This article reviews a number of developments in the efforts of electric utilities to establish two-way communications with their customers in order to develop products and services to fit each customer`s needs. In their efforts, utilities are facing an array of technology, including broadband, radio frequency, cellular, satellite, dial inbound, and power line carrier current. Individual efforts with each technology are noted. In many cases, the utilities are finding that existing cable and telephone companies are powerful allies in their efforts. Finding that their technology is marketable, the electric utilities are also diversifying horizontally and marketing their communications tools to other, both inside and outside of the utility industry.

Two-way radios and scanners for dummies

CERN Document Server

Silver, H Ward

2013-01-01

Discover a fun new hobby with helpful possibilities Get directions, talk to folks overseas, or find out whether the fish are biting Want to check out the morning news in London, help out in emergencies, or tune in to the big race? Two-way radios open up a world of possibilities - literally. This handy guide tells you about the equipment you need, fills you in on radio etiquette, shows you how to stay legal, and gives you lots of cool ideas for family-friendly radio activities. Discover how to * Use the right radio lingo * Choose and operate different types of radios * Get a license if you n

Two-period resource duopoly with endogenous intertemporal capacity constraints

International Nuclear Information System (INIS)

Berk, Istemi

2014-01-01

This paper analyzes the strategic firm behavior within the context of a two-period resource duopoly model in which firms face endogenous intertemporal capacity constraints. Firms are allowed to invest in capacity in between two periods in order to increase their initial endowment of exhaustible resource stocks. Using this setup, we nd that the equilibrium price weakly decreases over time. Moreover, asymmetric distribution of initial resource stocks leads to a significant change in equilibrium outcome, provided that firms do not have the same cost structure in capacity additions. It is also verified that if only one company is capable of investment in capacity, the market moves to a more concentrated structure in the second period.

Two-period resource duopoly with endogenous intertemporal capacity constraints

Energy Technology Data Exchange (ETDEWEB)

Berk, Istemi

2014-07-15

This paper analyzes the strategic firm behavior within the context of a two-period resource duopoly model in which firms face endogenous intertemporal capacity constraints. Firms are allowed to invest in capacity in between two periods in order to increase their initial endowment of exhaustible resource stocks. Using this setup, we nd that the equilibrium price weakly decreases over time. Moreover, asymmetric distribution of initial resource stocks leads to a significant change in equilibrium outcome, provided that firms do not have the same cost structure in capacity additions. It is also verified that if only one company is capable of investment in capacity, the market moves to a more concentrated structure in the second period.

Generalized periodic EEG activity in two cases of neurosyphilis

Directory of Open Access Journals (Sweden)

Anghinah Renato

2006-01-01

Full Text Available Neurosyphilis is a recognized cause of epileptic seizures and cognitive impairment, but is not usually associated with the finding of generalized periodic activity in the EEG. We report two similar cases characterized by progressive cognitive impairment followed by partial complex seizures, in whom the EEG showed generalized periodic activity. Both cerebrospinal fluid and the response to penicillin therapy confirmed the diagnoses of neurosyphilis in the two cases. The finding of EEG generalized periodic activity in patients with cognitive or behavioral disorders is usually associated with Creutzfeldt-Jakob disease, although there are other conditions, some of them potentially reversible, which may also present this EEG abnormality. Neurosyphilis has tended not to be included among them, and our present findings support the importance of first ruling out neurosyphilis in those patients with cognitive or behavioral disorders associated with generalized periodic epileptiform discharges.

Energy Efficient Design for Two-Way AF Relay Networks

Directory of Open Access Journals (Sweden)

Yong Li

2014-01-01

Full Text Available Conventional designs on two-way relay networks mainly focus on the spectral efficiency (SE rather than energy efficiency (EE. In this paper, we consider a system where two source nodes communicate with each other via an amplify-and-forward (AF relay node and study the power allocation schemes to maximize EE while ensuring a certain data rate. We propose an optimal energy-efficient power allocation algorithm based on iterative search technique. In addition, a closed-form suboptimal solution is derived with reduced complexity and negligible performance degradation. Numerical results show that the proposed schemes can achieve considerable EE improvement compared with conventional designs.

Numerical simulation of a device with two spin crossover complexes: application for temperature and pressure sensors

Science.gov (United States)

Linares, Jorge; Eddine Allal, Salah; Dahoo, Pierre Richard; Garcia, Yann

2017-12-01

The spin-crossover (SCO) phenomenon is related to the ability of a transition metal to change its spin state vs. a given perturbation. For an iron(II) SCO complexes the reversible changes involve the diamagnetic low-spin (S = 0) and the paramagnetic high-spin (HS S = 2) states [1,2,3]. In this contribution we simulate the HS Fraction (nHS) for different set values of temperature and pressure for a device using two SCO complexes with weak elastic interactions. We improve the calculation given by Linares et al. [4], taking also into account different volume (VHS, VLS) changes of the SCO. We perform all the calculation in the frame work of an Ising-like model solved in the mean-field approximation. The two SCO show in the case of “weak elastic interactions”, gradual spin transitions such that both temperature and pressure values can be obtained from the optical observation in the light of calculations discussed in this article.

Formation of two-way shape memory effect in rapid-quenched TiNiCu alloys

International Nuclear Information System (INIS)

Shelyakov, A.V.; Bykovsky, Yu.A.; Matveeva, N.M.; Kovneristy, Yu.K.

1995-01-01

Recently we have developed a number of devices for an optical radiation control based on the shape memory effect. A blind of rapid-quenched TiNiCu alloy having a two-way shape memory in bending was used as a basic element. So far as the rapid quenched alloy used is amorphous in initial state, it needs thermal annealing to form shape memory. This paper describes procedure of thermo-mechanical treatment, that allows to form desired two-way shape memory immediately during thermal annealing of amorphous alloy without training. It was shown that degree of two-way shape recovery depends critically on initial strain, temperature and duration of the annealing. It was experimentally determined optimum parameters of thermo-mechanical treatment to achieve maximum two-way shape memory. (orig.)

Improved two-way six-state protocol for quantum key distribution

International Nuclear Information System (INIS)

Shaari, J.S.; Bahari, Asma' Ahmad

2012-01-01

A generalized version for a qubit based two-way quantum key distribution scheme was first proposed in the paper [Phys. Lett. A 358 (2006) 85] capitalizing on the six quantum states derived from three mutually unbiased bases. While boasting of a higher level of security, the protocol was not designed for ease of practical implementation. In this work, we propose modifications to the protocol, resulting not only in improved security but also in a more efficient and practical setup. We provide comparisons for calculated secure key rates for the protocols in noisy and lossy channels. -- Highlights: ► Modification for efficient generalized two-way QKD is proposed. ► Calculations include secure key rates in noisy and lossy channels for selected attack scenario. ► Resulting proposal provides for higher secure key rate in selected attack scheme.

Improved two-way six-state protocol for quantum key distribution

Energy Technology Data Exchange (ETDEWEB)

Shaari, J.S., E-mail: jesni_shamsul@yahoo.com [Faculty of Science, International Islamic University Malaysia (IIUM), Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200 Kuantan, Pahang (Malaysia); Bahari, Asma' Ahmad [Faculty of Science, International Islamic University Malaysia (IIUM), Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200 Kuantan, Pahang (Malaysia)

2012-10-01

A generalized version for a qubit based two-way quantum key distribution scheme was first proposed in the paper [Phys. Lett. A 358 (2006) 85] capitalizing on the six quantum states derived from three mutually unbiased bases. While boasting of a higher level of security, the protocol was not designed for ease of practical implementation. In this work, we propose modifications to the protocol, resulting not only in improved security but also in a more efficient and practical setup. We provide comparisons for calculated secure key rates for the protocols in noisy and lossy channels. -- Highlights: ► Modification for efficient generalized two-way QKD is proposed. ► Calculations include secure key rates in noisy and lossy channels for selected attack scenario. ► Resulting proposal provides for higher secure key rate in selected attack scheme.

Comparative bioavailability and tolerability of a single 20-mg dose of two fluoxetine hydrochloride dispersible tablet formulations in fasting, healthy Chinese male volunteers: an open-label, randomized-sequence, two-period crossover study.

Science.gov (United States)

Shi, Shaojun; Liu, Yani; Wu, Jianhong; Li, Zhongfang; Zhao, Yan; Zhong, Dafang; Zeng, Fandian

2010-10-01

The proprietary formulation of fluoxetine hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor class. Pharmacokinetic studies investigating the bioequivalence of generic and branded formulations are needed to market generic fluoxetine in China. The aim of this study was to compare the bioavailability and tolerability of the proposed generic formulation with the established reference formulation of fluoxetine hydrochloride 20 mg in a fasting, healthy Chinese male population. This 10-week, open-label, randomized-sequence, single-dose, 2-period crossover study was conducted in healthy native Han Chinese male volunteers. Eligible subjects were randomly assigned in a 1:1 ratio to receive a single 20-mg dose of the test or reference formulation, followed by a 35-day washout period and administration of the alternate formulation. Doses were administered after a 12-hour overnight fast. For analysis of pharmacokinetic properties (including C(max), T(max), AUC(0-t), AUC(0-∞), and t(½)), blood samples were obtained over a 672-hour period after dosing. Plasma concentrations of fluoxetine and its active metabolite, norfluoxetine, were analyzed using a validated LC-MS/MS method. The formulations were to be considered bioequivalent if the ln-transformed ratios (test/ reference) of C(max) and AUC were within the predetermined bioequivalence range of 80% to 125%, as established by the US Food and Drug Administration, and if the P values were fasting, healthy Chinese male volunteers. Both formulations appeared to be well tolerated. Copyright © 2010 Excerpta Medica Inc. All rights reserved.

Comparison of several hydrological cycle parameters in Croatia for two periods

International Nuclear Information System (INIS)

Pandzic, Kreso; Trninic, Dusan

2004-01-01

Comparison of several hydrological cycle parameter averages for two periods in Croatia is considered. Parameters are: yearly averages of: 2m air temperature, precipitation amounts, potential and real evapotranspiration amounts. A basic period (1951-1980) and period for comparison (1981-1997) have been chosen. (These periods accepted at The First Sub-Regional Expert Meeting on the 'Assesment of Climate Change Impacts on the Hydrological Cycles in South-Eastern Europe' held in Sofia (Bulgaria) 17-20 February 1999.) Differences between two period averages for 30 weather stations have been calculated. Temperature differences and those for potential evaporation are positive while for precipitation they are mainly negative. Real evaporation differences for two periods are an exception i.e. they are positive in continental but negative in Mediterranean part of Croatia. These results agree with global warming trend. (Author)

Improvement of two-way continuous-variable quantum key distribution using optical amplifiers

International Nuclear Information System (INIS)

Zhang, Yi-Chen; Yu, Song; Gu, Wanyi; Li, Zhengyu; Sun, Maozhu; Peng, Xiang; Guo, Hong; Weedbrook, Christian

2014-01-01

The imperfections of a receiver's detector affect the performance of two-way continuous-variable (CV) quantum key distribution (QKD) protocols and are difficult to adjust in practical situations. We propose a method to improve the performance of two-way CV-QKD by adding a parameter-adjustable optical amplifier at the receiver. A security analysis is derived against a two-mode collective entangling cloner attack. Our simulations show that the proposed method can improve the performance of protocols as long as the inherent noise of the amplifier is lower than a critical value, defined as the tolerable amplifier noise. Furthermore, the optimal performance can approach the scenario where a perfect detector is used. (paper)

Response of stiff piles to random two-way lateral loading

DEFF Research Database (Denmark)

Bakmar, Christian LeBlanc; Byrne, B.W.; Houlsby, G. T.

2010-01-01

A model for predicting the accumulated rotation of stiff piles under random two-way loading is presented. The model is based on a strain superposition rule similar to Miner's rule and uses rainflow-counting to decompose a random time-series of varying loads into a set of simple load reversals. Th....... The method is consistent with the work of LeBlanc et al. (2010) and is supported by 1g laboratory tests. An example is given for an offshore wind turbine indicating that accumulated pile rotation during the life of the turbine is dominated by the worst expected load.......A model for predicting the accumulated rotation of stiff piles under random two-way loading is presented. The model is based on a strain superposition rule similar to Miner's rule and uses rainflow-counting to decompose a random time-series of varying loads into a set of simple load reversals...

An improved two-way continuous-variable quantum key distribution protocol with added noise in homodyne detection

International Nuclear Information System (INIS)

Sun Maozhu; Peng Xiang; Guo Hong

2013-01-01

We propose an improved two-way continuous-variable quantum key distribution (CV QKD) protocol by adding proper random noise on the receiver’s homodyne detection, the security of which is analysed against general collective attacks. The simulation result under the collective entangling cloner attack indicates that despite the correlation between two-way channels decreasing the secret key rate relative to the uncorrelated channels slightly, the performance of the two-way protocol is still far beyond that of the one-way protocols. Importantly, the added noise in detection is beneficial for the secret key rate and the tolerable excess noise of this two-way protocol. With the reasonable reconciliation efficiency of 90%, the two-way CV QKD with added noise allows the distribution of secret keys over 60 km fibre distance. (paper)

A bioequivalence study of two tamsulosin sustained-release tablets in Indonesian healthy volunteers.

Science.gov (United States)

Prasaja, Budi; Harahap, Yahdiana; Lusthom, Windy; Setiawan, Evy C; Ginting, Mena B; Hardiyanti; Lipin

2011-06-01

The bioavailability of two 0.4 mg tamsulosin sustained-release film-coated tablet formulations was compared; using generic tablets (Prostam(®)) as test formulation and the originator product as reference formulation. Twenty-four subjects were included in this single-dose, open-label, randomized two-way crossover design following an overnight fasting. A one-week wash-out period was applied. Blood samples were drawn up to 72 h following drug administration. Plasma concentration of tamsulosin was determined by liquid chromatography-tandem mass spectrometry method with TurboIonSpray mode. Pharmacokinetic parameters AUC(0-t,) AUC(0-∞), C (max) and t (½) were determined and used for bioequivalence evaluation after log-transformation, whereas t (max) ratios were evaluated non-parametrically. The estimated point and 90% confidence intervals (CI) for AUC(0-t,) AUC(0-∞), C (max) and t (½) were 109.55% (96.41-124.49%), 109.94% (96.85-124.81%), 105.87% (92.88-120.67%) and 100.00% (90.56-110.43%), respectively. These results indicated that the two formulations of tamsulosin were bioequivalent; therefore they may be prescribed interchangeably.

77 FR 58579 - Certain Two-Way Global Satellite Communication Devices, System and Components Thereof...

Science.gov (United States)

2012-09-21

... Communication Devices, System and Components Thereof; Institution of Investigation Pursuant to 19 U.S.C. 1337... certain two-way global satellite communication devices, system and components thereof that infringe one or... within the United States after importation of certain two-way global satellite communication devices...

Dynamics of two disks settling in a two-dimensional narrow channel: From periodic motion to vertical chain in Oldroyd-B fluid

Science.gov (United States)

Pan, Tsorng-Whay; Glowinski, Roland

2016-11-01

In this talk we present a numerical study of the dynamics of two disks settling in a narrow vertical channel filled with an Oldroyd-B fluid. Two kinds of particle dynamics are obtained: (i) periodic interaction between two disks and (ii) the formation of the chain of two disks. For the periodic interaction of two disks, two different motions are obtained: (a) two disks stay far apart and interact is periodically, which is similar to one of the motions of two disks settling in a narrow channel filled with a Newtonian fluid discussed by Aidun & Ding and (b) two disks draft, kiss and break away periodically and the chain is not formed due to not strong enough elastic force. For the formation of two disk chain occurred at higher values of the elasticity number, it is either a tilted chain or a vertical chain. The tilted chain can be obtained for either that the elasticity number is less than the critical value for having the vertical chain or that the Mach number is greater than the critical value for a long body to fall broadside-on, which is consistent with the results for the elliptic particles settling in Oldroyd-B fluids. NSF.

Gaussian elimination methods for calculating classical periodic trajectories in two dimensions

International Nuclear Information System (INIS)

Davies, K.T.R.

1991-08-01

A Gaussian-elimination method for calculating classical periodic trajectories is formulated for a two-dimensional system. Two variants of the theory are obtained, one assuming that the period of the motion is fixed and the other assuming that the total energy is fixed. Comparisons are made between various approaches. 14 refs

On the Achievable Rate-Regions for the Gaussian Two-way Diamond Channels

Directory of Open Access Journals (Sweden)

F. Askarian

2015-12-01

Full Text Available In this channel,we study rate region of a Gaussian two-way diamond channel which operates in half-duplex mode. In this channel, two transceiver (TR nodes exchange their messages with the help of two relay nodes. We consider a special case of the Gaussian two-way diamond channels which is called Compute-and-Forward Multiple Access Channel (CF-MAC. In the CF-MAC, the TR nodes transmit their messages to the relay nodes which are followed by a simultaneous communication from the relay nodes to the TRs. Adopting rate splitting method in the terminal encoders and then using Compute-and-Forward (CF relaying and decoding the sum of messages at the relay nodes, an achievable rate region for this channel is obtained. To this end, we use a superposition coding based on lattice codes. Using numerical results, we show that our proposed scheme has better performance than other similar methods and achieves a tighter gap to the outer bound.

A two-dimensional, two-phase mass transport model for liquid-feed DMFCs

International Nuclear Information System (INIS)

Yang, W.W.; Zhao, T.S.

2007-01-01

A two-dimensional, isothermal two-phase mass transport model for a liquid-feed direct methanol fuel cell (DMFC) is presented in this paper. The two-phase mass transport in the anode and cathode porous regions is formulated based on the classical multiphase flow in porous media without invoking the assumption of constant gas pressure in the unsaturated porous medium flow theory. The two-phase flow behavior in the anode flow channel is modeled by utilizing the drift-flux model, while in the cathode flow channel the homogeneous mist-flow model is used. In addition, a micro-agglomerate model is developed for the cathode catalyst layer. The model also accounts for the effects of both methanol and water crossover through the membrane. The comprehensive model formed by integrating those in the different regions is solved numerically using a home-written computer code and validated against the experimental data in the literature. The model is then used to investigate the effects of various operating and structural parameters, such as methanol concentration, anode flow rate, porosities of both anode and cathode electrodes, the rate of methanol crossover, and the agglomerate size, on cell performance

Two-Way Gene Interaction From Microarray Data Based on Correlation Methods.

Science.gov (United States)

Alavi Majd, Hamid; Talebi, Atefeh; Gilany, Kambiz; Khayyer, Nasibeh

2016-06-01

Gene networks have generated a massive explosion in the development of high-throughput techniques for monitoring various aspects of gene activity. Networks offer a natural way to model interactions between genes, and extracting gene network information from high-throughput genomic data is an important and difficult task. The purpose of this study is to construct a two-way gene network based on parametric and nonparametric correlation coefficients. The first step in constructing a Gene Co-expression Network is to score all pairs of gene vectors. The second step is to select a score threshold and connect all gene pairs whose scores exceed this value. In the foundation-application study, we constructed two-way gene networks using nonparametric methods, such as Spearman's rank correlation coefficient and Blomqvist's measure, and compared them with Pearson's correlation coefficient. We surveyed six genes of venous thrombosis disease, made a matrix entry representing the score for the corresponding gene pair, and obtained two-way interactions using Pearson's correlation, Spearman's rank correlation, and Blomqvist's coefficient. Finally, these methods were compared with Cytoscape, based on BIND, and Gene Ontology, based on molecular function visual methods; R software version 3.2 and Bioconductor were used to perform these methods. Based on the Pearson and Spearman correlations, the results were the same and were confirmed by Cytoscape and GO visual methods; however, Blomqvist's coefficient was not confirmed by visual methods. Some results of the correlation coefficients are not the same with visualization. The reason may be due to the small number of data.

Ferromagnetism in the two-dimensional periodic Anderson model

International Nuclear Information System (INIS)

Batista, C. D.; Bonca, J.; Gubernatis, J. E.

2001-01-01

Using the constrained-path Monte Carlo method, we studied the magnetic properties of the two-dimensional periodic Anderson model for electron fillings between 1/4 and 1/2. We also derived two effective low-energy theories to assist in interpreting the numerical results. For 1/4 filling, we found that the system can be a Mott or a charge-transfer insulator, depending on the relative values of the Coulomb interaction and the charge-transfer gap between the two noninteracting bands. The insulator may be a paramagnet or antiferromagnet. We concentrated on the effect of electron doping on these insulating phases. Upon doping we obtained a partially saturated ferromagnetic phase for low concentrations of conduction electrons. If the system were a charge-transfer insulator, we would find that the ferromagnetism is induced by the well-known Ruderman-Kittel-Kasuya-Yosida interaction. However, we found a novel correlated hopping mechanism inducing the ferromagnetism in the region where the nondoped system is a Mott insulator. Our regions of ferromagnetism spanned a much smaller doping range than suggested by recent slave boson and dynamical mean-field theory calculations, but they were consistent with that obtained by density-matrix renormalization group calculations of the one-dimensional periodic Anderson model

Two-dimensional wave propagation in layered periodic media

KAUST Repository

Quezada de Luna, Manuel

2014-09-16

We study two-dimensional wave propagation in materials whose properties vary periodically in one direction only. High order homogenization is carried out to derive a dispersive effective medium approximation. One-dimensional materials with constant impedance exhibit no effective dispersion. We show that a new kind of effective dispersion may arise in two dimensions, even in materials with constant impedance. This dispersion is a macroscopic effect of microscopic diffraction caused by spatial variation in the sound speed. We analyze this dispersive effect by using highorder homogenization to derive an anisotropic, dispersive effective medium. We generalize to two dimensions a homogenization approach that has been used previously for one-dimensional problems. Pseudospectral solutions of the effective medium equations agree to high accuracy with finite volume direct numerical simulations of the variable-coeffi cient equations.

Ka-Band Waveguide Two-Way Hybrid Combiner for MMIC Amplifiers

Science.gov (United States)

Simons, Rainee N.; Chevalier, Christine T.; Wintucky, Edwin G.; Freeman, Jon C.

2010-01-01

The design, simulation, and characterization of a novel Ka-band (32.05 0.25 GHz) rectangular waveguide two-way branch-line hybrid unequal power combiner (with port impedances matched to that of a standard WR-28 waveguide) has been created to combine input signals, which are in phase and with an amplitude ratio of two. The measured return loss and isolation of the branch-line hybrid are better than 22 and 27 dB, respectively. The measured combining efficiency is 92.9 percent at the center frequency of 32.05 GHz. This circuit is efficacious in combining the unequal output power from two Ka-band GaAs pseudomorphic high electron mobility transistor (pHEMT) monolithic microwave integrated circuit (MMIC) power amplifiers (PAs) with high efficiency. The component parts include the branch-line hybrid-based power combiner and the MMIC-based PAs. A two-way branch-line hybrid is a four-port device with all ports matched; power entering port 1 is divided in phase, and into the ratio 2:1 between ports 3 and 4. No power is coupled to port 2. MMICs are a type of integrated circuit fabricated on GaAs that operates at microwave frequencies, and performs the function of signal amplification. The power combiner is designed to operate over the frequency band of 31.8 to 32.3 GHz, which is NASA's deep space frequency band. The power combiner would have an output return loss better than 20 dB. Isolation between the output port and the isolated port is greater than 25 dB. Isolation between the two input ports is greater than 25 dB. The combining efficiency would be greater than 90 percent when the ratio of the two input power levels is two. The power combiner is machined from aluminum with E-plane split-block arrangement, and has excellent reliability. The flexibility of this design allows the combiner to be customized for combining the power from MMIC PAs with an arbitrary power output ratio. In addition, it allows combining a low-power GaAs MMIC with a high-power GaN MMIC. The arbitrary

Towards an explanation of age-related difficulties in crossing a two-way street

OpenAIRE

Dommes , Aurélie; LE LAY , Tristan; Vienne , Fabrice; DANG , Nguyen-Thong; PERROT BEAUDOIN , Alexandra; Do , Manh Cuong

2015-01-01

Crossing a two-way street is a complex task that involves visual, cognitive and motor abilities, all of which are known to decline with ageing. In particular, older pedestrians may experience difficulties when crossing two-way streets because of incorrect gap acceptance choices and impossible or unperceived evasive actions. To understand the overrepresentation of older pedestrians in crash statistics, several experimental studies have sought to identify traffic-related factors as well as thos...

Bifurcation analysis of the logistic map via two periodic impulsive forces

International Nuclear Information System (INIS)

Jiang Hai-Bo; Li Tao; Zeng Xiao-Liang; Zhang Li-Ping

2014-01-01

The complex dynamics of the logistic map via two periodic impulsive forces is investigated in this paper. The influences of the system parameter and the impulsive forces on the dynamics of the system are studied respectively. With the parameter varying, the system produces the phenomenon such as periodic solutions, chaotic solutions, and chaotic crisis. Furthermore, the system can evolve to chaos by a cascading of period-doubling bifurcations. The Poincaré map of the logistic map via two periodic impulsive forces is constructed and its bifurcation is analyzed. Finally, the Floquet theory is extended to explore the bifurcation mechanism for the periodic solutions of this non-smooth map. (general)

EEG/MEG Source Reconstruction with Spatial-Temporal Two-Way Regularized Regression

KAUST Repository

Tian, Tian Siva; Huang, Jianhua Z.; Shen, Haipeng; Li, Zhimin

2013-01-01

In this work, we propose a spatial-temporal two-way regularized regression method for reconstructing neural source signals from EEG/MEG time course measurements. The proposed method estimates the dipole locations and amplitudes simultaneously

A two-dimensional Fermi gas in the BEC-BCS crossover

Energy Technology Data Exchange (ETDEWEB)

Ries, Martin Gerhard

2016-01-21

This thesis reports on the preparation of a 2D Fermi gas in the BEC-BCS crossover and the observation of the BKT transition into a quasi long-range ordered superfluid phase. The pair momentum distribution of the gas is probed by means of a matter-wave focusing technique which relies on time-of-flight evolution in a weak harmonic potential. This distribution holds the coherence properties of the gas. The quasi long-range ordered phase manifests itself as a sharp low-momentum peak. The temperature where it forms is identified as the transition temperature. By tuning the temperature and the interaction strength, the phase diagram of the 2D Fermi gas in the BEC-BCS crossover is mapped out. The phase coherence is investigated in a self-interference experiment. Furthermore, algebraic decay of correlations is observed in the trap average of the first order correlation function, which is obtained from the Fourier transform of the pair momentum distribution. This is in qualitative agreement with predictions of homogeneous theory for the superfluid phase in a 2D gas. The presented results provide a foundation for future experimental and theoretical studies of strongly correlated 2D Fermi gases. They might thus help to elucidate complex systems such as the electron gas in high-T{sub c} superconductors.

Demonstration of Multisetting One-Way Einstein-Podolsky-Rosen Steering in Two-Qubit Systems

Science.gov (United States)

Xiao, Ya; Ye, Xiang-Jun; Sun, Kai; Xu, Jin-Shi; Li, Chuan-Feng; Guo, Guang-Can

2017-04-01

Einstein-Podolsky-Rosen (EPR) steering describes the ability of one party to remotely affect another's state through local measurements. One of the most distinguishable properties of EPR steering is its asymmetric aspect. Steering can work in one direction but fail in the opposite direction. This type of one-way steering, which is different from the symmetry concepts of entanglement and Bell nonlocality, has garnered much interest. However, an experimental demonstration of genuine one-way EPR steering in the simplest scenario, i.e., one that employs two-qubit systems, is still lacking. In this Letter, we experimentally demonstrate one-way EPR steering with multimeasurement settings for a class of two-qubit states, which are still one-way steerable even with infinite settings. The steerability is quantified by the steering radius, which represents a necessary and sufficient steering criterion. The demonstrated one-way steering in the simplest bipartite quantum system is of fundamental interest and may provide potential applications in one-way quantum information tasks.

Energy efficient design for MIMO two-way AF multiple relay networks

KAUST Repository

Alsharoa, Ahmad M.; Ghazzai, Hakim; Alouini, Mohamed-Slim

2014-01-01

This paper studies the energy efficient transmission and the power allocation problem for multiple two-way relay networks equipped with multi-input multi-output antennas where each relay employs an amplify-and-forward strategy. The goal

Study on stress characteristics of Francis hydraulic turbine runner based on two-way FSI

International Nuclear Information System (INIS)

Zhu, W R; Xiao, R F; Yang, W; Wang, F J; Liu, J

2012-01-01

In recent years, cracking phenomenon occurs in many large-sized turbines both nationally and internationally, which has threatened the stable operation of hydraulic turbines. Consequently, Stress characteristics calculation and analysis of a Francis hydraulic turbine runner by application of fluid-structure interaction (FSI) technology become significantly important. In order to introduce two-way coupling technology to hydraulic machinery, two-way FSI technology is applied in this article to calculate and analyze stress characteristics. Through coordinate system transformation, the continuity equations and Navier-Stokes equations in the Cartesian coordinates system are firstly transformed to ALE coordinates system. The fluid field control equations are then constructed and discrete equations can be obtained by using flow-condition-based interpolation (FBIC-C). The structure static mechanics equations used are established in rotation coordinate system, and modeled with the finite method. Two-way coupling is computed by using iteration method. The fluid equations and structure equations are iterated until coupling coefficients converge. According to structure result, the maximum stress, displacement as well as its location can be found. As a result, the most easily wear position can be discovered which provides valuable basis for optimized design and stable operation of Francis hydraulic turbines. After comparing the results with that of one-way coupling, it is discovered that displacements is the key factors which affects the results of one-way and two-way coupling.

Lexical need as a two-way reality cognition tool

OpenAIRE

Mark Kit; Elena Berg

2014-01-01

Lexical need as a two-way reality cognition tool In this paper a concept of lexical need is introduced and its application in research of cognitive aspects of translation is discussed. Further discussion elaborates mechanisms of development of translator’s lexical space in the course of translation. Authors discuss the importance and special nature of low-frequency lexical units and difficulties encountered when studying their usage and suggest that the lexical need concept help these stu...

Consumption of organic diets does not affect intake and absorption of zinc and copper in men-evidence from two cross-over trials

DEFF Research Database (Denmark)

Mark, Alicja Budek; Kápolna, Emese; Laursen, Kristian H.

2013-01-01

diets on intake and absorption of zinc and copper in men. Two double-blinded, cross-over, intervention trials (3 dietary periods of 12 days with 2-week-long wash-out) were performed in 2008 (n = 17) and 2009 (n = 16) in young men. The diets were based on 9 crops grown in rigidly controlled organic......Agricultural methods may affect the nutritional composition of plants and cause complex changes in the food matrix. Whether this affects the dietary absorption of minerals that are important for maintaining health thorough life remains unclear. We compared the effects of organic and conventional......; 12.35 ± 0.47 mg per 10 MJ and 44.6% ± 12.1, respectively) and copper (overall mean ± SD; 2.12 ± 0.28 mg per 10 MJ and 41.2% ± 13.2, respectively) were not different between the organic and conventional diets. The growing season had no effect on zinc intake and absorption, but the copper intake...

The Lack of Effect of Food on the Pharmacokinetics of ZX008 (Fenfluramine Oral Solution): Results of a Single-dose, Two-period Crossover Study.

Science.gov (United States)

Gammaitoni, Arnold; Smith, Steven; Boyd, Brooks

2018-06-22

Fenfluramine is being developed as a low-dose adjunctive treatment for seizures in patients with Dravet syndrome and other epileptic encephalopathies, including Lennox-Gastaut syndrome. Most patients with Dravet syndrome receive multiple antiepileptic drugs, making it challenging for caregivers to track correct administration times. The present Phase I study was conducted to determine the effect of food on the pharmacokinetic properties of fenfluramine. Healthy nonsmoking subjects aged 18 to 50years were enrolled in an open-label, crossover, Phase I pharmacokinetic and safety profile study and received 2 single 0.8-mg/kg doses of ZX008 (fenfluramine hydrochloride oral solution), 1 after a 10-hour overnight fast and the other 30 minutes after the start of consumption of a high-fat breakfast, in a randomly assigned order. A washout period of at least 9days separated the 2 treatment periods. Venous blood samples were taken before each dose and periodically for 72hours after each dose for determination of concentrations of fenfluramine and its active metabolite norfenfluramine. Plasma pharmacokinetic parameters were estimated for each subject by noncompartmental analysis. In the 13 subjects completing both treatment periods, food had no effect on the rate or extent of absorption and bioavailability of fenfluramine as assessed by fed vs fasted adjusted geometric mean observed plasma C max (59.1vs 56.7 ng/mL; NS) and AUC 0-∞ (1640vs 1600 ng · h/mL; NS). Additionally, there was no impact of food on systemic exposure of norfenfluramine. Seven subjects reported at least 1 treatment-emergent adverse event; all treatment-emergent adverse events were mild in severity. The bioequivalence and tolerability of single 0.8-mg/kg oral doses of ZX008 in the fed and fasted states support ZX008 administration without regard to meals. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

Relative bioavailability of two oral formulations of risperidone 2 mg: A single-dose, randomized-sequence, open-label, two-period crossover comparison in healthy Brazilian volunteers.

Science.gov (United States)

Belotto, Karisa Cristina Rodrigues; Raposo, Nádia Rezende Barbosa; Ferreira, Aline Siqueira; Gattaz, Wagner Farid

2010-11-01

Risperidone (RSP) is a benzisoxazole antipsychotic agent used to treat schizophrenia and other psychiatric illnesses in adults and children (including those with autism). After oral administration, RSP is completely absorbed from the gastrointestinal tract and undergoes hydroxylation to yield 9-hydroxyrisperidone (9-OH-RSP), an active metabolite that has a pharmacologic profile and potency similar to RSP. The aims of this study were to compare the relative bioavailability of a pharmaceutical-equivalent (test) formulation with a reference formulation of oral RSP 2 mg, both available commercially on the Brazilian pharmaceutical market, and to generate data regarding the oral bioavailability of the tested drug in healthy Brazilian volunteers. This single-dose, randomized-sequence, open-label, 2-period crossover study was conducted in healthy Brazilian volunteers from August to December 2008. Subjects were randomly assigned to receive the test formulation followed by the reference formulation or vice versa, with a 30-day washout period between doses. Study drugs were administered after a 12-hour overnight fast. For pharmacokinetic analysis, blood samples were drawn at 0 (baseline), 0.25, 0.5, 1, 1.5, 3, 5, 8, 12, 24, 48, 72, 96, and 120 hours after administration. Plasma concentrations of RSP and 9-OH-RSP were determined using LC-MS/MS. The test and reference formulations were to be considered bioequivalent if the 90% CIs for the geometric mean test/reference ratios were within a predetermined range of 80% to 125%, in accordance with the policies of the Brazilian Sanitary Surveillance Agency and the US Food and Drug Administration. Tolerability was determined using clinical assessments, monitoring of vital signs, analysis of laboratory test results, and subject interviews regarding adverse events. A total of 22 subjects were enrolled (11 men, 11 women; mean [SD] age, 32 [12] years [range, 1858 years]; weight, 70.4 [11.9] kg [range, 50-103 kg]; height, 1.67 [0.08] m

Measure of departure from marginal point-symmetry for two-way contingency tables

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Kouji Yamamoto

2013-05-01

Full Text Available For two-way contingency tables, Tomizawa (1985 considered the point-symmetry and marginal point-symmetry models, and Tomizawa, Yamamoto and Tahata (2007 proposed a measure to represent the degree of departure from point-symmetry. The present paper proposes a measure to represent the degree of departure from marginal pointsymmetry for two-way tables. The proposed measure is expressed by using Cressie-Read power-divergence or Patil-Taillie diversity index. This measure would be useful for comparing the degrees of departure from marginal point-symmetry in several tables. The relationship between the degree of departure from marginal point-symmetry and the measure is shown when it is reasonable to assume underlying bivariate normal distribution. Examples are shown.

Two-way text messaging: an interactive mobile learning environment in higher education

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H.K. Salinda Premadasa

2016-11-01

Full Text Available Short messaging service (SMS is perhaps the most popular mobile technology prevalent among students in higher education due to its ubiquitous nature and the capability of two-way communication. However, a major limitation in two-way text messaging is sending back a part of received data with the reply message. This limitation results in users of a mobile learning environment being unable to reply back to the correct destination. This article presents a two-way text messaging system that can be integrated into a learning management system (LMS to provide an interactive learning experience to the user community. Initially, a database is integrated into the LMS that holds message information such as recipient's phone number, message body and user data header. A specific port associated with the SMS is used to conceal and exchange data of a particular course unit. Subsequently, software in the student's mobile device captures this message and sends back the reply message to the appropriate course unit allowing both teachers and students to view messages sent and replies received pertaining to a particular course. Results indicate the educational impact of the proposed system in improving the learning environment and benefits it offers to the community in a campus-wide implementation.

Two-Phase Gas-Liquid Flow Structure Characteristics under Periodic Cross Forces Action

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V. V. Perevezentsev

2015-01-01

Full Text Available The article presents a study of two-phase gas-liquid flow under the action of periodic cross forces. The work objective is to obtain experimental data for further analysis and have structure characteristics of the two-phase flow movement. For research, to obtain data without disturbing effect on the flow were used optic PIV (Particle Image Visualization methods because of their noninvasiveness. The cross forces influence was provided by an experimental stand design to change the angular amplitudes and the periods of channel movement cycle with two-phase flow. In the range of volume gas rates was shown a water flow rate versus the inclination angle of immovable riser section and the characteristic angular amplitudes and periods of riser section inclination cycle under periodic cross forces. Data on distribution of average water velocity in twophase flow in abovementioned cases were also obtained. These data allowed us to draw a conclusion that a velocity distribution depends on the angular amplitude and on the period of the riser section roll cycle. This article belongs to publications, which study two-phase flows with no disturbing effect on them. Obtained data give an insight into understanding a pattern of twophase gas-liquid flow under the action of periodic cross forces and can be used to verify the mathematical models of the CFD thermo-hydraulic codes. In the future, the work development expects taking measurements with more frequent interval in the ranges of angular amplitudes and periods of the channel movement cycle and create a mathematical model to show the action of periodic cross forces on two-phase gas-liquid flow.

Towards an explanation of age-related difficulties in crossing a two-way street.

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Dommes, Aurélie; Lay, Tristan Le; Vienne, Fabrice; Dang, Nguyen-Thong; Beaudoin, Alexandra Perrot; Do, Manh Cuong

2015-12-01

Crossing a two-way street is a complex task that involves visual, cognitive and motor abilities, all of which are known to decline with ageing. In particular, older pedestrians may experience difficulties when crossing two-way streets because of incorrect gap acceptance choices and impossible or unperceived evasive actions. To understand the overrepresentation of older pedestrians in crash statistics, several experimental studies have sought to identify traffic-related factors as well as those related to the abilities of the individuals themselves. However, none of these studies has required participants to actually walk across an experimental two-way street with curbs, which is a particularly challenging situation for older pedestrians. To fill this research gap, a quasi-experiment was conducted in a simulator including a total of 58 healthy aged participants (25 younger-old [age 60-72] and 33 older-old [age 72-92]) and 25 young adults (aged 18-25 years). Participants carried out a street-crossing task in a simulated two-way traffic environment; curbs were present on both sides of the experimental street. Participants also undertook a battery of tests to assess their visual and cognitive abilities. In addition, during the experiment, the participants' gait parameters were recorded. In line with earlier findings, the older-old group of participants made a higher number of decisions that led to collisions with approaching cars compared with the other groups. The two groups of older participants experienced specific difficulties when vehicles were in the far lane or when they approached rapidly. A regression analysis identified visual acuity, speed of processing (assessed using the UFOV(®) test), and step length as significant predictors of collisions. Our results have implications for understanding the difficulties experienced by older pedestrians and allow to draw up several recommendations for improving their safety. Copyright © 2015 Elsevier Ltd. All rights

Discussing Difference: Color-Blind Collectivism and Dynamic Dissonance in Two-Way Immersion Contexts

Science.gov (United States)

Stolte, Laurel

2017-01-01

This comparative case study (based on observational, interview, and picture-sort data) examines how teachers and students talk about cultural, linguistic, racial, and socioeconomic difference in two elementary Spanish-English two-way immersion programs. In addition, I analyze how those discourses are associated with both contextual conditions and…

Improve the teaching quality by two-way education mode

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Hongyan Shi

2017-02-01

Full Text Available Teaching activities contain teaching and learning, and both teachers and students have to work hard to improve the quality of teaching. This essay introduced the basic conception of “two-way and five-ring” mode first, and expatiated on the structure of this mode. The author used her own experiences to combine the teaching mode with the real situation of military school, emphasized teaching itself and talked about some spe-cific plans. This will give a certain extend help in improving the quality of teaching in military school.

Self-similarities of periodic structures for a discrete model of a two-gene system

International Nuclear Information System (INIS)

Souza, S.L.T. de; Lima, A.A.; Caldas, I.L.; Medrano-T, R.O.; Guimarães-Filho, Z.O.

2012-01-01

We report self-similar properties of periodic structures remarkably organized in the two-parameter space for a two-gene system, described by two-dimensional symmetric map. The map consists of difference equations derived from the chemical reactions for gene expression and regulation. We characterize the system by using Lyapunov exponents and isoperiodic diagrams identifying periodic windows, denominated Arnold tongues and shrimp-shaped structures. Period-adding sequences are observed for both periodic windows. We also identify Fibonacci-type series and Golden ratio for Arnold tongues, and period multiple-of-three windows for shrimps. -- Highlights: ► The existence of noticeable periodic windows has been reported recently for several nonlinear systems. ► The periodic window distributions appear highly organized in two-parameter space. ► We characterize self-similar properties of Arnold tongues and shrimps for a two-gene model. ► We determine the period of the Arnold tongues recognizing a Fibonacci-type sequence. ► We explore self-similar features of the shrimps identifying multiple period-three structures.

Self-similarities of periodic structures for a discrete model of a two-gene system

Energy Technology Data Exchange (ETDEWEB)

Souza, S.L.T. de, E-mail: thomaz@ufsj.edu.br [Departamento de Física e Matemática, Universidade Federal de São João del-Rei, Ouro Branco, MG (Brazil); Lima, A.A. [Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, MG (Brazil); Caldas, I.L. [Instituto de Física, Universidade de São Paulo, São Paulo, SP (Brazil); Medrano-T, R.O. [Departamento de Ciências Exatas e da Terra, Universidade Federal de São Paulo, Diadema, SP (Brazil); Guimarães-Filho, Z.O. [Aix-Marseille Univ., CNRS PIIM UMR6633, International Institute for Fusion Science, Marseille (France)

2012-03-12

We report self-similar properties of periodic structures remarkably organized in the two-parameter space for a two-gene system, described by two-dimensional symmetric map. The map consists of difference equations derived from the chemical reactions for gene expression and regulation. We characterize the system by using Lyapunov exponents and isoperiodic diagrams identifying periodic windows, denominated Arnold tongues and shrimp-shaped structures. Period-adding sequences are observed for both periodic windows. We also identify Fibonacci-type series and Golden ratio for Arnold tongues, and period multiple-of-three windows for shrimps. -- Highlights: ► The existence of noticeable periodic windows has been reported recently for several nonlinear systems. ► The periodic window distributions appear highly organized in two-parameter space. ► We characterize self-similar properties of Arnold tongues and shrimps for a two-gene model. ► We determine the period of the Arnold tongues recognizing a Fibonacci-type sequence. ► We explore self-similar features of the shrimps identifying multiple period-three structures.

Data verification and materials accountancy for two accounting periods

International Nuclear Information System (INIS)

Beedgen, R.

1985-01-01

In the framework of near-real-time accountancy for nuclear materials, safeguards statistical analysis based on the operator's data of a sequence of materials balance periods has been performed. Up to now, it is assumed that the operator's data are correct. A statistical model is presented that enables inspector verification measurements for a sequence of accounting periods to be included into a safeguards procedure. The analysis uses a two balance period and statistical concepts which are applied in the case of one accounting period. The interconnection of different safeguards measures shall be studied to get a basic idea about the procedure and it is shown that there might be fundamental differences to the one balance case

Perspektif Karyawan Perbankan pada Komunikasi Internal dengan Two-Way Symmetrical Communication dan Internal Marketing

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Mia Angeline

2013-04-01

Full Text Available The article investigates the internal communication in the two branches of foreign banks in Kelapa Gading from the perspectives of two-way symmetrical communication and internal marketing. The second problem investigated is the effectiveness of the use of email as a means of internal communication. Data were collected through interviews and literature. The results showed that the perception of employees not in accordance with the concept of two-way communication and internal marketing, but this policy has led the organization to these concepts. In the use of email, employee perceptions still see that the email is an effective internal communication media despite having many weaknesses.  

Bioequivalence of Liposome-Entrapped Paclitaxel Easy-To-Use (LEP-ETU) formulation and paclitaxel in polyethoxylated castor oil: a randomized, two-period crossover study in patients with advanced cancer.

Science.gov (United States)

Slingerland, Marije; Guchelaar, Henk-Jan; Rosing, Hilde; Scheulen, Max E; van Warmerdam, Laurence J C; Beijnen, Jos H; Gelderblom, Hans

2013-12-01

Preclinical studies comparing paclitaxel formulated with polyethoxylated castor oil with the sonicated formulation of liposome-entrapped paclitaxel (LEP) have demonstrated that LEP was associated with reduced toxicity while maintaining similar efficacy. Preliminary studies on the pharmacokinetics in patients support earlier preclinical data, which suggested that the LEP Easy-to-Use (LEP-ETU) formulation and paclitaxel formulated with castor oil may have comparable pharmacokinetic properties. Our objectives were: (1) to determine bioequivalence of paclitaxel pharmaceutically formulated as LEP-ETU (test) and paclitaxel formulated with castor oil (reference); and (2) to assess the tolerability of LEP-ETU following intravenous administration. Patients with advanced cancer were studied in a randomized, 2-period crossover bioequivalence study. Patients received paclitaxel 175 mg/m(2) administered as an intravenous infusion over 180 minutes, either as a single-treatment cycle of the test formulation followed by a single-treatment cycle of the reference formulation, or vice versa. Thirty-two of 58 patients were evaluable and were included in the analysis for bioequivalence. Mean total paclitaxel Cmax values for the test and reference formulations were 4955.0 and 5108.8 ng/mL, respectively. Corresponding AUC0-∞ values were 15,853.8 and 18,550.8 ng·h/mL, respectively. Treatment ratios of the geometric means were 97% (90% CI, 91%-103%) for Cmax and 84% (90% CI, 80%-90%) for AUC0-∞. These results met the required 80% to 125% bioequivalence criteria. The most frequently reported adverse events after LEP-ETU administration were fatigue, alopecia, and myalgia. At the studied dose regimen, LEP-ETU showed bioequivalence with paclitaxel formulated with polyethoxylated castor oil. © 2013 Elsevier HS Journals, Inc. All rights reserved.

One-way versus two-way text messaging on improving medication adherence: meta-analysis of randomized trials.

Science.gov (United States)

Wald, David S; Butt, Shahena; Bestwick, Jonathan P

2015-10-01

Mobile telephone text messaging is a simple potential solution to the failure to take medications as directed. There is uncertainty over the effectiveness of 1-way text messaging (sending text message reminders only) compared with 2-way text messaging (sending reminders and receiving replies confirming whether medication has been taken) as a means of improving medication adherence. A meta-analysis of 8 randomized trials (1994 patients) that tested the effectiveness of text messaging on medication adherence was performed. The trials were divided into 2 groups: trials using 1-way text messaging versus no text messaging and trials using 2-way text messaging versus no text messaging. The summary estimates of the effect of the 2 methods of text messaging (1-way or 2-way) were compared. The summary relative risk estimate was 1.04 (95% confidence interval, 0.97-1.11) for 1-way text messaging and 1.23 (95% confidence interval, 1.13-1.35) for 2-way text messaging. The difference in effect between the 2 methods was statistically significant (P = .007). Two-way text messaging is associated with substantially improved medication adherence compared with 1-way text messaging. This has important implications in the provision of mobile-based messaging in the management of patients taking medication for the prevention of chronic disease. Copyright © 2015 Elsevier Inc. All rights reserved.

Thermomechanical behavior of a two-way shape memory composite actuator

International Nuclear Information System (INIS)

Ge, Qi; Westbrook, Kristofer K; Dunn, Martin L; Jerry Qi, H; Mather, Patrick T

2013-01-01

Shape memory polymers (SMPs) are a class of smart materials that can fix a temporary shape and recover to their permanent (original) shape in response to an environmental stimulus such as heat, electricity, or irradiation, among others. Most SMPs developed in the past can only demonstrate the so-called one-way shape memory effect; i.e., one programming step can only yield one shape memory cycle. Recently, one of the authors (Mather) developed a SMP that exhibits both one-way shape memory (1W-SM) and two-way shape memory (2W-SM) effects (with the assistance of an external load). This SMP was further used to develop a free-standing composite actuator with a nonlinear reversible actuation under thermal cycling. In this paper, a theoretical model for the PCO SMP based composite actuator was developed to investigate its thermomechanical behavior and the mechanisms for the observed phenomena during the actuation cycles, and to provide insight into how to improve the design. (paper)

Crossing rule for a PT-symmetric two-level time-periodic system

International Nuclear Information System (INIS)

Moiseyev, Nimrod

2011-01-01

For a two-level system in a time-periodic field we show that in the non-Hermitian PT case the level crossing is of two quasistationary states that have the same dynamical symmetry property. At the field's parameters where the two levels which have the same dynamical symmetry cross, the corresponding quasienergy states coalesce and a self-orthogonal state is obtained. This situation is very different from the Hermitian case where a crossing of two quasienergy levels happens only when the corresponding two quasistationary states have different dynamical symmetry properties and, unlike the situation in the non-Hermitian case, the spectrum remains complete also when the two levels cross.

77 FR 51045 - Certain Two-Way Global Satellite Communication Devices, System and Components Thereof; Notice of...

Science.gov (United States)

2012-08-23

... Certain Two-Way Global Satellite Communication Devices, System and Components Thereof, DN 2907; the... INTERNATIONAL TRADE COMMISSION [Docket No. 2907] Certain Two-Way Global Satellite Communication Devices, System and Components Thereof; Notice of Receipt of Complaint; Solicitation of Comments Relating...

Outage performance of two-way DF relaying systems with a new relay selection metric

KAUST Repository

Hyadi, Amal; Benjillali, Mustapha; Alouini, Mohamed-Slim

2012-01-01

This paper investigates a new constrained relay selection scheme for two-way relaying systems where two end terminals communicate simultaneously via a relay. The introduced technique is based on the maximization of the weighted sum rate of both

Secrecy in Wireless Information and Power Transfer for One-Way and Two-Way Untrusted Relaying with Friendly Jamming

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Lin Xiao

2017-01-01

Full Text Available An untrusted relay system combined with a simultaneous wireless information and power transfer (SWIPT scheme is considered in one-way and two-way relaying transmission strategies. In the system, two source nodes can only communicate with each other via an untrusted energy harvesting relay node, which sends the message by using its harvested energy from the source nodes. Specifically, we classify the intermediate relay as an eavesdropper into two modes: active eavesdropper and nonactive eavesdropper, depending on whether it has sufficient energy of its own to transmit the message or not. Under a simplified three-node fading wiretap channel setup, the transmit power allocation and power splitting ratio are jointly optimized to minimize the outage probability in the delay-sensitive case and to maximize the average rate in the delay-insensitive case, subject to the average and peak total power constraints. Applying the dual-decomposition method, the optimization problem can be efficiently solved in the delay-sensitive scenario. Moreover, an iterative algorithm is proposed to derive the solution to maximize the average rate in the delay-insensitive scenario. Numerical results demonstrate the performance of system outage probability in the two modes versus different rates and how efficiently the secrecy rate is improved compared with traditional schemes.

QCD thermodynamics with two flavors at Nt=6

Science.gov (United States)

Bernard, Claude; Ogilvie, Michael C.; Degrand, Thomas A.; Detar, Carleton; Gottlieb, Steven; Krasnitz, Alex; Sugar, R. L.; Toussaint, D.

1992-05-01

The first results of numerical simulations of quantum chromodynamics on the Intel iPSC/860 parallel processor are presented. We performed calculations with two flavors of Kogut-Susskind quarks at Nt=6 with masses of 0.15T and 0.075T (0.025 and 0.0125 in lattice units) in order to locate the crossover from the low-temperature regime of ordinary hadronic matter to the high-temperature chirally symmetric regime. As with other recent two-flavor simulations, these calculations are insufficient to distinguish between a rapid crossover and a true phase transition. The phase transition is either absent or feeble at this quark mass. An improved estimate of the crossover temperature in physical units is given and results are presented for the hadronic screening lengths in both the high- and low-temperature regimes.

Two-Way Communication with a Single Quantum Particle

Science.gov (United States)

Del Santo, Flavio; Dakić, Borivoje

2018-02-01

In this Letter we show that communication when restricted to a single information carrier (i.e., single particle) and finite speed of propagation is fundamentally limited for classical systems. On the other hand, quantum systems can surpass this limitation. We show that communication bounded to the exchange of a single quantum particle (in superposition of different spatial locations) can result in "two-way signaling," which is impossible in classical physics. We quantify the discrepancy between classical and quantum scenarios by the probability of winning a game played by distant players. We generalize our result to an arbitrary number of parties and we show that the probability of success is asymptotically decreasing to zero as the number of parties grows, for all classical strategies. In contrast, quantum strategy allows players to win the game with certainty.

Environmental periodicity and the coexistence problem for two competing and dispersive species

International Nuclear Information System (INIS)

Elion-Mboussa, A.

1994-11-01

The dynamic behaviour of two competing and dispersive species in a heterogeneous space and periodically fluctuating environment is studied. Periodic environmental factors were incorporated into a non-linear reaction-diffusion model, through intrinsic demographic parameters of one of the two species sharing the same favourable space. Furthermore, it was assumed that the physical environmental factors do not have an effect on the growth rate of one of the species. An ecological example of these assumptions is a host- parasite system where parasite reproduction is strongly seasonal, while host populations remain insensitive to physical environmental factors that affect the parasite populations. However, the induced effect of physical environmental factors on the non-affected species was established by means of computer calculations. The periodic oscillations which over the time lead to competitive coexistence of both species with periodic forced oscillations have been shown. It was also shown that, in a periodic environment and under appropriate initial conditions, two competing and dispersive species can coexist when in a constant environment they could not coexist. (author). 25 refs, 12 figs

Two-Way Multiuser Mixed RF/FSO Relaying: Performance Analysis and Power Allocation

KAUST Repository

Al-Eryani, Yasser F.; Salhab, Anas; Zummo, Salam A.; Alouini, Mohamed-Slim

2018-01-01

In this paper, the performance of two-way multiuser mixed radio frequency/free space optical (RF/FSO) relay networks with opportunistic user scheduling and asymmetric channel fading is studied. RF links are used to conduct data transmission between

Coordinating two-period ordering and advertising policies in a dynamic market with stochastic demand

Science.gov (United States)

Wang, Junping; Wang, Shengdong; Min, Jie

2015-03-01

In this paper, we study the optimal two-stage advertising and ordering policies and the channel coordination issues in a supply chain composed of one manufacturer and one retailer. The manufacturer sells a short-life-cycle product through the retailer facing stochastic demand in dynamic markets characterised by price declines and product obsolescence. Following a two-period newsvendor framework, we develop two members' optimal ordering and advertising models under both the centralised and decentralised settings, and present the closed-form solutions to the developed models as well. Moreover, we design a two-period revenue-sharing contract, and develop sufficient conditions such that the channel coordination can be achieved and a win-win outcome can be guaranteed. Our analysis suggests that the centralised decision creates an incentive for the retailer to increase the advertising investments in two periods and put the purchase forward, but the decentralised decision mechanism forces the retailer to decrease the advertising investments in two periods and postpone/reduce its purchase in the first period. This phenomenon becomes more evident when demand variability is high.

Conservative adaptivity and two-way self-nesting using discrete wavelets

Science.gov (United States)

Dubos, Thomas

2010-05-01

In simulating atmosphere and oceans, multiscale modelling is desirable to track high-intensity weather patterns, to investigate the interactions between the various spatio-temporal scales of the climate system, and to perform assessments of climate change at scales small enough to derive impacts on society and ecosystems. The mainstream approach to multiscale modelling is to nest a fine, limited-area model into a coarse, global model. These models are then coupled, either one-way or two-way, in order to combine the global coverage of the global model and the fine details of the fine model. In the long simulations typical of climate studies, initial conditions are unimportant, except for the few quantities like mass that are exactly conserved. In this context it is crucial that numerical models conserve at least mass exactly at the discrete level. However even with elaborate strategies like adaptive mesh refinement (AMR) conservation is not straightforwardly achieved. Although the continuous wavelet transform has become a standard tool of geophysical data analysis, it is less known that discrete wavelets and the associated transforms provide the basis for spatially adaptive numerical methods. Such methods are now well-developed in the fluid dynamics community. Since they allow spatial adaptivity, they can also be seen as two-way self-nesting methods. However since they are not specifically designed for geophysical purposes they are usually not exactly conservative. I present a fairly general framework in which a wavelet-based layer is added to an existing conservative scheme (finite-volume or finite-difference) to make it spatially adaptive without breaking the exact conservation of linear invariants. Discrete wavelet transforms involve an upscaling operation by which fields are transferred from a fine grid to a coarser grid with half the resolution. The method requires that mass fluxes be upscaled in a way that is consistent with the upscaling of mass. This

Bidirectional Active Learning: A Two-Way Exploration Into Unlabeled and Labeled Data Set.

Science.gov (United States)

Zhang, Xiao-Yu; Wang, Shupeng; Yun, Xiaochun

2015-12-01

In practical machine learning applications, human instruction is indispensable for model construction. To utilize the precious labeling effort effectively, active learning queries the user with selective sampling in an interactive way. Traditional active learning techniques merely focus on the unlabeled data set under a unidirectional exploration framework and suffer from model deterioration in the presence of noise. To address this problem, this paper proposes a novel bidirectional active learning algorithm that explores into both unlabeled and labeled data sets simultaneously in a two-way process. For the acquisition of new knowledge, forward learning queries the most informative instances from unlabeled data set. For the introspection of learned knowledge, backward learning detects the most suspiciously unreliable instances within the labeled data set. Under the two-way exploration framework, the generalization ability of the learning model can be greatly improved, which is demonstrated by the encouraging experimental results.

Optimal relay selection and power allocation for cognitive two-way relaying networks

KAUST Repository

Pandarakkottilil, Ubaidulla; Aï ssa, Sonia

2012-01-01

In this paper, we present an optimal scheme for power allocation and relay selection in a cognitive radio network where a pair of cognitive (or secondary) transceiver nodes communicate with each other assisted by a set of cognitive two-way relays

An approach to combining parallel and cross-over trials with and without run-in periods using individual patient data.

Science.gov (United States)

Tvete, Ingunn F; Olsen, Inge C; Fagerland, Morten W; Meland, Nils; Aldrin, Magne; Smerud, Knut T; Holden, Lars

2012-04-01

In active run-in trials, where patients may be excluded after a run-in period based on their response to the treatment, it is implicitly assumed that patients have individual treatment effects. If individual patient data are available, active run-in trials can be modelled using patient-specific random effects. With more than one trial on the same medication available, one can obtain a more precise overall treatment effect estimate. We present a model for joint analysis of a two-sequence, four-period cross-over trial (AABB/BBAA) and a three-sequence, two-period active run-in trial (AB/AA/A), where the aim is to investigate the effect of a new treatment for patients with pain due to osteoarthritis. Our approach enables us to separately estimate the direct treatment effect for all patients, for the patients excluded after the active run-in trial prior to randomisation, and for the patients who completed the active run-in trial. A similar model approach can be used to analyse other types of run-in trials, but this depends on the data and type of other trials available. We assume equality of the various carry-over effects over time. The proposed approach is flexible and can be modified to handle other designs. Our results should be encouraging for those responsible for planning cost-efficient clinical development programmes.

Lexical need as a two-way reality cognition tool

Directory of Open Access Journals (Sweden)

Mark Kit

2014-09-01

Full Text Available Lexical need as a two-way reality cognition tool In this paper a concept of lexical need is introduced and its application in research of cognitive aspects of translation is discussed. Further discussion elaborates mechanisms of development of translator’s lexical space in the course of translation. Authors discuss the importance and special nature of low-frequency lexical units and difficulties encountered when studying their usage and suggest that the lexical need concept help these studies. Lexical need analysis can be also used to learn specifics of translator’s lexical space and then to take measures for selection of translators and improvement of their skills.

Towards Efficient Wireless Body Area Network Using Two-Way Relay Cooperation.

Science.gov (United States)

Waheed, Maham; Ahmad, Rizwan; Ahmed, Waqas; Drieberg, Micheal; Alam, Muhammad Mahtab

2018-02-13

The fabrication of lightweight, ultra-thin, low power and intelligent body-borne sensors leads to novel advances in wireless body area networks (WBANs). Depending on the placement of the nodes, it is characterized as in/on body WBAN; thus, the channel is largely affected by body posture, clothing, muscle movement, body temperature and climatic conditions. The energy resources are limited and it is not feasible to replace the sensor's battery frequently. In order to keep the sensor in working condition, the channel resources should be reserved. The lifetime of the sensor is very crucial and it highly depends on transmission among sensor nodes and energy consumption. The reliability and energy efficiency in WBAN applications play a vital role. In this paper, the analytical expressions for energy efficiency (EE) and packet error rate (PER) are formulated for two-way relay cooperative communication. The results depict better reliability and efficiency compared to direct and one-way relay communication. The effective performance range of direct vs. cooperative communication is separated by a threshold distance. Based on EE calculations, an optimal packet size is observed that provides maximum efficiency over a certain link length. A smart and energy efficient system is articulated that utilizes all three communication modes, namely direct, one-way relay and two-way relay, as the direct link performs better for a certain range, but the cooperative communication gives better results for increased distance in terms of EE. The efficacy of the proposed hybrid scheme is also demonstrated over a practical quasi-static channel. Furthermore, link length extension and diversity is achieved by joint network-channel (JNC) coding the cooperative link.

Towards Efficient Wireless Body Area Network Using Two-Way Relay Cooperation

Directory of Open Access Journals (Sweden)

Maham Waheed

2018-02-01

Full Text Available The fabrication of lightweight, ultra-thin, low power and intelligent body-borne sensors leads to novel advances in wireless body area networks (WBANs. Depending on the placement of the nodes, it is characterized as in/on body WBAN; thus, the channel is largely affected by body posture, clothing, muscle movement, body temperature and climatic conditions. The energy resources are limited and it is not feasible to replace the sensor’s battery frequently. In order to keep the sensor in working condition, the channel resources should be reserved. The lifetime of the sensor is very crucial and it highly depends on transmission among sensor nodes and energy consumption. The reliability and energy efficiency in WBAN applications play a vital role. In this paper, the analytical expressions for energy efficiency (EE and packet error rate (PER are formulated for two-way relay cooperative communication. The results depict better reliability and efficiency compared to direct and one-way relay communication. The effective performance range of direct vs. cooperative communication is separated by a threshold distance. Based on EE calculations, an optimal packet size is observed that provides maximum efficiency over a certain link length. A smart and energy efficient system is articulated that utilizes all three communication modes, namely direct, one-way relay and two-way relay, as the direct link performs better for a certain range, but the cooperative communication gives better results for increased distance in terms of EE. The efficacy of the proposed hybrid scheme is also demonstrated over a practical quasi-static channel. Furthermore, link length extension and diversity is achieved by joint network-channel (JNC coding the cooperative link.

Relating two proposed methods for speedup of algorithms for fitting two- and three-way principal component and related multilinear models

NARCIS (Netherlands)

Kiers, Henk A.L.; Harshman, Richard A.

Multilinear analysis methods such as component (and three-way component) analysis of very large data sets can become very computationally demanding and even infeasible unless some method is used to compress the data and/or speed up the algorithms. We discuss two previously proposed speedup methods.

QCD thermodynamics with two flavors at Nt=6

International Nuclear Information System (INIS)

Bernard, C.; Ogilvie, M.C.; DeGrand, T.A.; DeTar, C.; Gottlieb, S.; Krasnitz, A.; Sugar, R.L.; Toussaint, D.

1992-01-01

The first results of numerical simulations of quantum chromodynamics on the Intel iPSC/860 parallel processor are presented. We performed calculations with two flavors of Kogut-Susskind quarks at N t =6 with masses of 0.15T and 0.075T (0.025 and 0.0125 in lattice units) in order to locate the crossover from the low-temperature regime of ordinary hadronic matter to the high-temperature chirally symmetric regime. As with other recent two-flavor simulations, these calculations are insufficient to distinguish between a rapid crossover and a true phase transition. The phase transition is either absent or feeble at this quark mass. An improved estimate of the crossover temperature in physical units is given and results are presented for the hadronic screening lengths in both the high- and low-temperature regimes

Influence of compressive load conditions and thickness on the two-way shape memory behavior in tube-shaped NiTi alloy

International Nuclear Information System (INIS)

Yoo, Young Ik; Shin, Dong Kil; Lee, Jung Ju; Lee, Chang Ho

2012-01-01

The two-way shape memory behavior of Ni 55 Ti 45 was investigated to develop a tube-shaped NiTi actuator which could generate a large amount of force. The two-way shape memory effect (TWSME) was induced by thermal cycling under various amounts of constant compressive stress. Six specimens with the same outer diameter and different thickness were used to apply the TWSME to an actuator. A fast saturation tendency of the recovery strain was shown through training at each level of constant stress, after which the two-way shape memory strain was quantitatively measured during thermal cycling for each level of applied stress. From the results, the maximum two-way strain value was obtained after training at a constant level of stress and then decreased thereafter. In addition, the two-way strain was found to depend on the thickness of the tube-shaped specimen. All specimens could be divided into two groups depending on the rate of increase in the two-way strain. After two-way strain was obtained, the two-way recovery stress was measured to verify the performance of the sample as an actuator. The results showed that the two-way recovery stress behavior was similar to the two-way strain; if the optimal thickness of the specimen and the stress applied for training are used for the development of the TWSME, tube-shaped NiTi using the TWSME can replace one-way shape memory alloys. (paper)

Evaluation of two supplements for the prevention of alfalfa bloat.

OpenAIRE

Hall, J W; Walker, I; Majak, W

1994-01-01

Poloxalene and a mineral mixture feed supplement patented for the treatment of emphysema, polyarthritis, and other pectin related diseases were tested in two trials for their ability to prevent bloat in cattle fed fresh alfalfa. Each trial had a crossover design using three Jersey steers with rumen fistulas per group. Each trial period continued until the total number of cases of bloat reached > or = 24. Treatments were given at 0800 each day. The mineral mixture was given at 100 g/d and 190 ...

Relative bioavailability of generic and branded acetylcysteine effervescent tablets: A single-dose, open-label, randomized-sequence, two-period crossover study in fasting healthy Chinese male volunteers.

Science.gov (United States)

Liu, Yan-Mei; Liu, Yun; Lu, Chuan; Jia, Jing-Ying; Liu, Gang-Yi; Weng, Li-Ping; Wang, Jia-Yan; Li, Guo-Xiu; Wang, Wei; Li, Shui-Jun; Yu, Chen

2010-11-01

Acetylcysteine may be used as a muco- lytic agent for the treatment of chronic bronchitis, chronic obstructive pulmonary disease, and other pulmonary diseases complicated by the production of viscous mucus. However, little is known of its pharmacokinetic properties when given orally in healthy volunteers, particularly in a Chinese Han population. This study was conducted to provide support for the marketing of a generic product in China. The purpose of this study was to compare the pharmacokinetics and relative bioavailability of a generic test formulation and a branded reference formulation of acetylcysteine in fasting healthy Chinese male volunteers. A single-dose, open-label, randomized-sequence, 2-period crossover design with a 7-day washout period between doses was used in this study. Healthy Chinese male nonsmokers aged 18 to 40 years with a body mass index (BMI) of 19 to 25 kg/m(2) were selected. Eligible volunteers were randomly assigned to receive acetylcysteine 600 mg PO as either the test formulation (3 tablets of 200 mg each) or reference formulation (1 tablet of 600 mg) under fasting conditions. A total of 15 serial blood samples were collected over a 24-hour interval, and total plasma acetylcysteine concentrations were analyzed by a validated liquid chromatography-isotopic dilution mass spectrometry method. Pharmacokinetic parameters (C(max), T(max), t(½) AUC(0-t), and AUC(0-∞) were calculated and analyzed statistically. The 2 formulations were considered bioequivalent if the 90% CIs of the log-transformed ratios (test/reference) of C(max) and AUC were within the predetermined bioequivalence ranges (70%-143% for C(max); 80%-125% for AUC), as established by the State Food and Drug Administration of China. Tolerability was determined by vital signs, clinical laboratory tests, 12-lead ECGs, physical examinations, and interviews with the subjects about adverse events (AEs). A total of 24 healthy Chinese Han male volunteers were enrolled in and

Assessing Fan Flutter Stability in Presence of Inlet Distortion Using One-Way and Two-Way Coupled Methods

Science.gov (United States)

Herrick, Gregory P.

2014-01-01

Concerns regarding noise, propulsive efficiency, and fuel burn are inspiring aircraft designs wherein the propulsive turbomachines are partially (or fully) embedded within the airframe; such designs present serious concerns with regard to aerodynamic and aeromechanic performance of the compression system in response to inlet distortion. Previously, a preliminary design of a forward-swept high-speed fan exhibited flutter concerns in clean-inlet flows, and the present author then studied this fan further in the presence of off-design distorted in-flows. Continuing this research, a three-dimensional, unsteady, Navier-Stokes computational fluid dynamics code is again applied to analyze and corroborate fan performance with clean inlet flow and now with a simplified, sinusoidal distortion of total pressure at the aerodynamic interface plane. This code, already validated in its application to assess aerodynamic damping of vibrating blades at various flow conditions using a one-way coupled energy-exchange approach, is modified to include a two-way coupled timemarching aeroelastic simulation capability. The two coupling methods are compared in their evaluation of flutter stability in the presence of distorted in-flows.

Periodicity effects on compound waves guided by a thin metal slab sandwiched between two periodically nonhomogeneous dielectric materials

Science.gov (United States)

Chiadini, Francesco; Fiumara, Vincenzo; Scaglione, Antonio; Lakhtakia, Akhlesh

2017-10-01

Surface-plasmon-polariton waves can be compounded when a sufficiently thin metal layer is sandwiched between two half spaces filled with dissimilar periodically nonhomogeneous dielectric materials. We solved the boundary-value problem for compound waves guided by a layer of a homogeneous and isotropic metal sandwiched between a structurally chiral material (SCM) and a periodically multilayered isotropic dielectric (PMLID) material. We found that the periodicities of the PMLID material and the SCM are crucial to excite a multiplicity of compound guided waves arising from strong coupling between the two interfaces.

Antihyperalgesic efficacy of 5% lidocaine medicated plaster in capsaicin and sunburn pain models--two randomized, double-blinded, placebo-controlled crossover trials in healthy volunteers.

Science.gov (United States)

Gustorff, Burkhard; Hauer, David; Thaler, Johannes; Seis, Astrid; Draxler, Julia

2011-12-01

The aim of this research is to analyze analgesic efficacy of the 5% lidocaine medicated plaster in two randomized, double-blinded, placebo-controlled, crossover studies in 16 healthy volunteers using capsaicin and sunburn pain models. Lidocaine and placebo plasters were simultaneously applied to forearms and thighs at contralateral body sites for three alternating 12-h plaster-on/plaster-off periods. Between the second and third plaster-on period, 4.2-cm circular spots on both pretreated thighs were irradiated with three times the individual minimal erythema dose of UVB light. After the last plaster-on period, 20 μl of 0.1% capsaicin was injected intradermally into both forearms. The study was repeated using a single 12-h plaster application. The area of pinprick hyperalgesia was diminished by 53% (p sunburn model; the intensity of mechanical hyperalgesia to rigid filaments (8 - 512 mN) was reduced in both models. Cold pain perception threshold was reduced (19.7°C ± 8.0 vs 21.8°C ± 6.8 for placebo, p sunburn). Similar effects were observed in the 12-h exposure study. No effect was seen on capsaicin-induced spontaneous pain and flare size, or blood flow in the sunburn area, and heat hyperalgesia in either study. Lidocaine plaster effectively treats mechanical hyperalgesia and cold pain.

Periodic trajectories for a two-dimensional nonintegrable Hamiltonian

International Nuclear Information System (INIS)

Baranger, M.; Davies, K.T.R.

1987-01-01

A numerical study is made of the classical periodic trajectories for the two-dimensional nonintegrable Hamiltonian H = 1/2(p 2 /sub x/+p 2 /sub y/)+(y-1/2x 2 ) 2 +0.05 x 2 . In addition to x--y pictures of the trajectories, E--tau (energy--period) plots of the periodic families are presented. Efforts have been ade to include all trajectories with short periods and all simple branchings of these trajectories. The monodromy matrix has been calculated in all cases, and from it the stability properties are derived. The topology of the E--tau plot has been explored, with the following results. One family may have several stable regions. The plot is not completely connected; there are islands. The plot is not a tree; there are cycles. There are isochronous branchings, period-doublings, and period-multiplyings of higher orders, and examples of each of these are presented. There is often more than one branch issuing from a branch point. Some general empirical rules are inferred. In particular, the existence of isochronous branching is seen to be a consequence of the symmetry of the Hamiltonian. All these results agree with the general classification of possible branchings derived in Ref. [10]. (M. A. M. de Aguiar, C. P. Malta, M. Baranger, and K. T. R. Davies, in preparation). Finally, some nonperiodic trajectories are calculated to illustrate the fact that stable periodic trajectories lie in ''regular'' regions of phase space, while unstable ones lie in ''chaotic'' regions

Interesting new two-way communication system between power supplier and customer; Spennende toveisteknologi

Energy Technology Data Exchange (ETDEWEB)

Bakken, Stein Arne

2002-07-01

The Norwegian company Wireless Reading Systems (WRS) have developed a special solution for two-way communication, with relatively low costs of both investment and operation. This two-way technology is based on radio communication and so is wireless. What is unique lies in the small chip that is easily mounted on the electric meter. It reads the numbers on the electric meter optically and transmits the data to a server. The reader is a semiconductor in a very compact form and includes two processors, internal memory and a camera, with the optics directly on the electronics. The chip also includes a small radio. The device is called the Recaps Terminal. It has a serial input and can be connected directly to some kWh-meters. The Recaps can also be used to count pulses, it can be used as alarm monitor, to control relays etc. The data coming from the terminals at the customers are transmitted as radio signals to a so-called Cecaps base station. This is a concentrator that covers 500-2000 Recaps units in a geographic area. This concentrator communicates with C31 data centre by way of WLAN, LAN, GSM or other means. The supervising unit in the system is the C31 data centre, which is a central data system for receiving readings and controlling the radio network.

Sociolinguistic Variation and Acquisition in Two-Way Language Immersion: Negotiating the Standard

Science.gov (United States)

Starr, Rebecca Lurie

2016-01-01

This book investigates the acquisition of sociolinguistic knowledge in the early elementary school years of a Mandarin-English two-way immersion program in the United States. Using ethnographic observation and quantitative analysis of data, the author explores how input from teachers and classmates shapes students' language acquisition. The book…

Secure Communication for Two-Way Relay Networks with Imperfect CSI

Directory of Open Access Journals (Sweden)

Cong Sun

2017-09-01

Full Text Available This paper considers a two-way relay network, where two legitimate users exchange messages through several cooperative relays in the presence of an eavesdropper, and the Channel State Information (CSI of the eavesdropper is imperfectly known. The Amplify-and-Forward (AF relay protocol is used. We design the relay beamforming weights to minimize the total relay transmit power, while requiring the Signal-to-Noise-Ratio (SNRs of the legitimate users to be higher than the given thresholds and the achievable rate of the eavesdropper to be upper-bounded. Due to the imperfect CSI, a robust optimization problem is summarized. A novel iterative algorithm is proposed, where the line search technique is applied, and the feasibility is preserved during iterations. In each iteration, two Quadratically-Constrained Quadratic Programming (QCQP subproblems and a one-dimensional subproblem are optimally solved. The optimality property of the robust optimization problem is analyzed. Simulation results show that the proposed algorithm performs very close to the non-robust model with perfect CSI, in terms of the obtained relay transmit power; it~achieves higher secrecy rate compared to the existing work. Numerically, the proposed algorithm converges very quickly, and more than 85% of the problems are solved optimally.

Two-way Fluid-Structure Interaction Simulation of a Micro Horizontal Axis Wind Turbine

Directory of Open Access Journals (Sweden)

Yi-Bao Chen

2015-01-01

Full Text Available A two-way Fluid-Structure Interaction (FSI analyses performed on a micro horizontal axis wind turbine (HAWT which coupled the CFX solver with Structural solver in ANSYS Workbench was conducted in this paper. The partitioned approach-based non-conforming mesh methods and the k-ε turbulence model were adopted to perform the study. Both the results of one-way and two-way FSI analyses were presented and compared with each other, and discrepancy of the results, especially the mechanical properties, were analysed. Grid convergence which is crucial to the results was performed, and the relationship between the inner flow field domain (rotational domain and the number of grids (number of cells, elements was verified for the first time. Dynamical analyses of the wind turbine were conducted using the torque as a reference value, to verify the rationality of the model which dominates the accuracy of results. The optimal case was verified and used to conduct the study, thus, the results derived from the simulation of the FSI are accurate and credible.

Quantum hacking of two-way continuous-variable quantum key distribution using Trojan-horse attack

International Nuclear Information System (INIS)

Ma Hong-Xin; Bao Wan-Su; Li Hong-Wei; Chou Chun

2016-01-01

We present a Trojan-horse attack on the practical two-way continuous-variable quantum key distribution system. Our attack mainly focuses on the imperfection of the practical system that the modulator has a redundancy of modulation pulse-width, which leaves a loophole for the eavesdropper inserting a Trojan-horse pulse. Utilizing the unique characteristics of two-way continuous-variable quantum key distribution that Alice only takes modulation operation on the received mode without any measurement, this attack allows the eavesdropper to render all of the final keys shared between the legitimate parties insecure without being detected. After analyzing the feasibility of the attack, the corresponding countermeasures are put forward. (paper)

Improved simulation of tropospheric ozone by a global-multi-regional two-way coupling model system

Directory of Open Access Journals (Sweden)

Y. Yan

2016-02-01

Full Text Available Small-scale nonlinear chemical and physical processes over pollution source regions affect the tropospheric ozone (O3, but these processes are not captured by current global chemical transport models (CTMs and chemistry–climate models that are limited by coarse horizontal resolutions (100–500 km, typically 200 km. These models tend to contain large (and mostly positive tropospheric O3 biases in the Northern Hemisphere. Here we use the recently built two-way coupling system of the GEOS-Chem CTM to simulate the regional and global tropospheric O3 in 2009. The system couples the global model (at 2.5° long.  ×  2° lat. and its three nested models (at 0.667° long.  ×  0.5° lat. covering Asia, North America and Europe, respectively. Specifically, the nested models take lateral boundary conditions (LBCs from the global model, better capture small-scale processes and feed back to modify the global model simulation within the nested domains, with a subsequent effect on their LBCs. Compared to the global model alone, the two-way coupled system better simulates the tropospheric O3 both within and outside the nested domains, as found by evaluation against a suite of ground (1420 sites from the World Data Centre for Greenhouse Gases (WDCGG, the United States National Oceanic and Atmospheric Administration (NOAA Earth System Research Laboratory Global Monitoring Division (GMD, the Chemical Coordination Centre of European Monitoring and Evaluation Programme (EMEP, and the United States Environmental Protection Agency Air Quality System (AQS, aircraft (the High-performance Instrumented Airborne Platform for Environmental Research (HIAPER Pole-to-Pole Observations (HIPPO and Measurement of Ozone and Water Vapor by Airbus In- Service Aircraft (MOZAIC and satellite measurements (two Ozone Monitoring Instrument (OMI products. The two-way coupled simulation enhances the correlation in day-to-day variation of afternoon mean surface O3

Large band gaps of water waves through two-dimensional periodic topography

International Nuclear Information System (INIS)

Yang Shaohua; Wu Fugen; Zhong Huilin; Zhong Lanhua

2006-01-01

In this Letter, the band structures and band gaps of liquid surface waves propagating over two-dimensional periodic topography was investigated by plane-waves expansion method. The periodic topography drilled by square hollows with square lattice was considered. And the effects of the filling fraction and the orientation of bottom-hollows on the band gaps are investigated in detail

Two-way CSI-assisted AF relaying with HPA nonlinearity

KAUST Repository

Qi, Jian

2015-09-11

In this paper, we investigate half-duplex two-way dual-hop channel state information (CSI)-assisted amplify-andforward (AF) relaying in the presence of high-power amplifier (HPA) nonlinearity at relays. The expression for the end-toend signal-to-noise ratio (SNR) is derived as per the modified system model by taking into account the interference caused by relaying scheme and HPA nonlinearity. The system performance of the considered relaying network is evaluated in terms of average symbol error probability (SEP) in Nakagami-m fading channels, by making use of the moment-generating function (MGF) approach. Numerical results are provided and show the effects of several parameters, such as quadrature amplitude modulation (QAM) order, number of relays, HPA parameters, and Nakagami parameter, on performance. © 2015 IEEE.

Unsupervised Two-Way Clustering of Metagenomic Sequences

Directory of Open Access Journals (Sweden)

Shruthi Prabhakara

2012-01-01

Full Text Available A major challenge facing metagenomics is the development of tools for the characterization of functional and taxonomic content of vast amounts of short metagenome reads. The efficacy of clustering methods depends on the number of reads in the dataset, the read length and relative abundances of source genomes in the microbial community. In this paper, we formulate an unsupervised naive Bayes multispecies, multidimensional mixture model for reads from a metagenome. We use the proposed model to cluster metagenomic reads by their species of origin and to characterize the abundance of each species. We model the distribution of word counts along a genome as a Gaussian for shorter, frequent words and as a Poisson for longer words that are rare. We employ either a mixture of Gaussians or mixture of Poissons to model reads within each bin. Further, we handle the high-dimensionality and sparsity associated with the data, by grouping the set of words comprising the reads, resulting in a two-way mixture model. Finally, we demonstrate the accuracy and applicability of this method on simulated and real metagenomes. Our method can accurately cluster reads as short as 100 bps and is robust to varying abundances, divergences and read lengths.

Periodic solutions for a two-species nonautonomous competition system with diffusion and impulses

International Nuclear Information System (INIS)

Dong Lingzhen; Chen Lansun; Shi Peilin

2007-01-01

By re-estimating the upper bound of ∫ 0 ω e u i (t) dt (i=1,2), we generalize a result about the existence of a positive periodic solution for a two-species nonautonomous patchy competition system with time delay. Based on that system, we consider the impulsive harvesting and stocking, and establish a two-species nonautonomous competition Lotka-Volterra system with diffusion and impulsive effects. With the continuation theorem of coincidence degree theory, we obtain the existence of a positive periodic solution for such a system. At last, two examples are given to demonstrate our results

Estimating reaction rate constants from a two-step reaction: a comparison between two-way and three-way methods

NARCIS (Netherlands)

Bijlsma, S.; Smilde, A. K.

2000-01-01

In this paper, two different spectral datasets are used in order to estimate reaction rate constants using different algorithms. Dataset 1 consists of short-wavelength near-infrared (SW NIR) spectra taken in time of the two-step epoxidation of 2,5-di-tert-butyl-1,4-benzoquinone using tert-butyl

Two-Way Communication between Scientists and the Public: A View from Science Communication Trainers in North America

Science.gov (United States)

Yuan, Shupei; Oshita, Tsuyoshi; AbiGhannam, Niveen; Dudo, Anthony; Besley, John C.; Koh, Hyeseung E.

2017-01-01

The current study explores the degree to which two-way communication is applied in science communication contexts in North America, based on the experiences of science communication trainers. Interviews with 24 science communication trainers suggest that scientists rarely focus on applying two-way communication tactics, such as listening to their…

Bandwidth and power allocation for two-way relaying in overlay cognitive radio systems

KAUST Repository

Alsharoa, Ahmad M.; Ghazzai, Hakim; Yaacoub, Elias E.; Alouini, Mohamed-Slim

2014-01-01

In this paper, the problem of both bandwidth and power allocation for two-way multiple relay systems in overlay cognitive radio (CR) setup is investigated. In the CR overlay mode, primary users (PUs) cooperate with cognitive users (CUs) for mutual

Patient-reported outcomes in patients with overactive bladder treated with mirabegron and tolterodine in a prospective, double-blind, randomized, two-period crossover, multicenter study (PREFER).

Science.gov (United States)

Herschorn, Sender; Staskin, David; Tu, Le Mai; Fialkov, Jonathan; Walsh, Terry; Gooch, Katherine; Schermer, Carol R

2018-04-19

The PREFER study was an assessment of medication tolerability, treatment preference and symptom improvement during treatment with mirabegron (M) and tolterodine (T) extended release (ER) in patients with overactive bladder (OAB). In this analysis of PREFER, patient-reported outcomes (PROs) were assessed during treatment. PREFER was a two-period, 8-week crossover, double-blind, phase IV study (NCT02138747) of treatment-naïve adults with OAB ≥3 months randomized to 1 of 4 treatment sequences (M/T; T/M; M/M; T/T), separated by a 2-week washout. Tolterodine ER was dosed at 4 mg for 8 weeks and mirabegron was dosed at 25 mg for 4 weeks then increased to 50 mg for the next 4 weeks. At each visit, PROs related to treatment satisfaction, quality of life and symptom bother were assessed using the OAB Satisfaction (OAB-S; 3 independent scales/5 single-item overall assessments), OAB-q (total health-related QoL [HRQoL] and subscales [Sleep, Social, Coping, Concern] and Symptom Bother scale) and Patient Perception of Bladder Condition (PPBC) questionnaires. Responder rates were reported for OAB-q subscales based on a minimal important difference (MID; ≥ 10-point improvement) and OAB-S Medication Tolerability score ≥ 90. In total, 358 randomized patients received ≥1 dose of double-blind study medication and completed ≥1 post-baseline value (OAB-S scale, OAB-q, PPBC): M/T (n = 154), T/M (n = 144), M/M (n = 30) or T/T (n = 30). At end of treatment (EoT), mirabegron and tolterodine ER were associated with similar mean improvements in 7 of the 8 OAB-S scores investigated, OAB-q scales and PPBC. A higher percentage of patients achieved clinically relevant improvements (MID) in OAB-q scales and OAB-S Medication Tolerability score during treatment with mirabegron than tolterodine ER. On average, patients with OAB experienced improvements in treatment satisfaction, HRQoL and symptom bother that were of a similar magnitude during treatment with

Obtaining local reflectivity at two-way travel time by filtering acoustic reflection data

NARCIS (Netherlands)

Slob, E.C.; Zhang, L.; Wapenaar, C.P.A.; Mihai Popovici, A.; Fomel, S.

2017-01-01

A modified implementation of Marchenko redatuming leads to a filter that removes internal multiples from reflection data. It produces local reflectivity at two-way travel time. The method creates new primary reflections resulting from emitted events that eliminate internal multiples. We call these

Development of a Portable Two-Way Communication and Information Device for Deafblind People.

Science.gov (United States)

Ozioko, Oliver; Hersh, Marion

2015-01-01

This paper presents research on the development of a wearable two-way communication and information device for deafblind people who use tactile communications methods, namely the British deafblind manual alphabet and/or Braille. The device has two components: a glove worn by the deafblind person and a handheld display with keypad to be used by their hearing and sighted communication partner. Users can send messages using pressure sensors embedded in the glove and receive them by means of vibration on the palm. The two components are linked by Bluetooth and the use of Bluetooth to communicate with computers, mobile phones and other Bluetooth enabled devices is being investigated. The design was informed by feedback obtained from a survey of deafblind people and interviews with staff in two organisations for deafblind people. Research and development of the device is still ongoing.

Mechanical properties of two-way grid shells optimized considering roundness and elastic stiffness

International Nuclear Information System (INIS)

Ogawa, Toshiyuki; Yuta, Nishikawa; Rie, Tateishi; Ohsaki, Makoto

2002-01-01

A single-layer two-way grid shell defined by Bezier surface is optimized by coordinates of the control points as design variables. The purpose of this paper is to find optimal shapes considering roundness and elastic stiffness, and to investigate their mechanical properties. The distance of the center of curvature from the specified point is used for formulating the objective function for generating a round shape. Consider next a problem of minimizing the compliance as mechanical performance measure. The compliance is defined by the external work against the static loads applied to the nodes. The mechanically optimal shape is different from the round shape. Therefore, the multi objective optimization problem is formulated for optimizing the two objectives, which are roundness and the elastic stiffness defined by using the compliance. The constraint method is used for obtaining Pareto optimal solutions between the two objectives. We optimize single-layer two-way grid shells with square and rectangle plans. Mechanical properties of the optimal shapes are investigated by compliance and the distributions of axial force and bending moment. The round shape is significantly dominated by the bending moment and its compliance is large. The bending moment of the mechanically optimal shape is not very large, and the latticed shell has large stiffness through axial deformation. A trade-off shape is round enough, and the influence of the bending moment is smaller than that of the optimal round shape and the elastic stiffness is moderately large

Two-Way Interactive Television: An Emerging Technology for University Level Business School Instruction.

Science.gov (United States)

Heiens, Richard A.; Hulse, Deborah B.

1996-01-01

An organizational behavior course was delivered via two-way interactive television to a campus site (71 students) and three remote locations (48 students). Remote students were slightly older and predominantly female. There were no significant differences in academic performance between on-campus and remote students. (SK)

Students' Ways of Thinking about Two-Variable Functions and Rate of Change in Space

Science.gov (United States)

Weber, Eric David

2012-01-01

This dissertation describes an investigation of four students' ways of thinking about functions of two variables and rate of change of those two-variable functions. Most secondary, introductory algebra, pre-calculus, and first and second semester calculus courses do not require students to think about functions of more than one variable. Yet…

Symmetry breaking in optimal timing of traffic signals on an idealized two-way street.

Science.gov (United States)

Panaggio, Mark J; Ottino-Löffler, Bertand J; Hu, Peiguang; Abrams, Daniel M

2013-09-01

Simple physical models based on fluid mechanics have long been used to understand the flow of vehicular traffic on freeways; analytically tractable models of flow on an urban grid, however, have not been as extensively explored. In an ideal world, traffic signals would be timed such that consecutive lights turned green just as vehicles arrived, eliminating the need to stop at each block. Unfortunately, this "green-wave" scenario is generally unworkable due to frustration imposed by competing demands of traffic moving in different directions. Until now this has typically been resolved by numerical simulation and optimization. Here, we develop a theory for the flow in an idealized system consisting of a long two-way road with periodic intersections. We show that optimal signal timing can be understood analytically and that there are counterintuitive asymmetric solutions to this signal coordination problem. We further explore how these theoretical solutions degrade as traffic conditions vary and automotive density increases.

Symmetry breaking in optimal timing of traffic signals on an idealized two-way street

Science.gov (United States)

Panaggio, Mark J.; Ottino-Löffler, Bertand J.; Hu, Peiguang; Abrams, Daniel M.

2013-09-01

Simple physical models based on fluid mechanics have long been used to understand the flow of vehicular traffic on freeways; analytically tractable models of flow on an urban grid, however, have not been as extensively explored. In an ideal world, traffic signals would be timed such that consecutive lights turned green just as vehicles arrived, eliminating the need to stop at each block. Unfortunately, this “green-wave” scenario is generally unworkable due to frustration imposed by competing demands of traffic moving in different directions. Until now this has typically been resolved by numerical simulation and optimization. Here, we develop a theory for the flow in an idealized system consisting of a long two-way road with periodic intersections. We show that optimal signal timing can be understood analytically and that there are counterintuitive asymmetric solutions to this signal coordination problem. We further explore how these theoretical solutions degrade as traffic conditions vary and automotive density increases.

Masticatory performance of complete denture wearers after using two adhesives: a crossover randomized clinical trial.

Science.gov (United States)

de Oliveira Junior, Norberto Martins; Rodriguez, Larissa Santana; Mendoza Marin, Danny Omar; Paleari, André Gustavo; Pero, Ana Carolina; Compagnoni, Marco Antonio

2014-11-01

Masticatory performance analysis of conventional complete denture wearers who use denture adhesives is scarce in the dental literature. The purpose of this study was to assess the effect of the use of 2 denture adhesives on the masticatory performance of conventional complete denture wearers by means of a crossover study. Forty individuals who were edentulous received new maxillary and mandibular complete dentures, and, after an adaptation period, were submitted to masticatory performance analysis without denture adhesive (control). The participants were randomly divided and assigned to 2 protocols: protocol 1, denture adhesive 1 (Ultra Corega cream tasteless) use during the first 15 days, followed by no use of denture adhesive over the next 15 days (washout), and then use of denture adhesive 2 (Ultra Corega powder tasteless) for 15 days; protocol 2, denture adhesive 2 (Ultra Corega powder tasteless) use during the first 15 days, followed by no use of denture adhesive during the next 15 days (washout), and then use of denture adhesive 1 (Ultra Corega cream tasteless) for 15 days. The masticatory performance was assessed immediately after the use of denture adhesive by means of the sieve method, in which participants were instructed to deliberately chew 5 almonds for 20 chewing strokes. Masticatory performance was calculated by the weight of comminuted material that passed through the sieves. Data were analyzed by a 1-way ANOVA for paired samples and the multiple comparison of means by using the Bonferroni test (α=.05). A significant increase in masticatory performance was noted after using the Ultra Corega cream (mean, 32.6%) and Ultra Corega powder (mean, 31.2%) when compared with the control group (mean, 19.8%) (Padhesives evaluated. The use of denture adhesive improved the masticatory performance of conventional complete denture wearers. No difference was found in masticatory performance with the use of cream or powder denture adhesive. Copyright © 2014

Rate Optimization of Two-Way Relaying with Wireless Information and Power Transfer

Directory of Open Access Journals (Sweden)

Thinh Phu Do

2017-11-01

Full Text Available We consider the simultaneous wireless information and power transfer in two-phase decode-and-forward two-way relaying networks, where a relay harvests the energy from the signal to be relayed through either power splitting or time splitting. Here, we formulate the resource allocation problems optimizing the time-phase and signal splitting ratios to maximize the sum rate of the two communicating devices. The joint optimization problems are shown to be convex for both the power splitting and time splitting approaches after some transformation if required to be solvable with an existing solver. To lower the computational complexity, we also present the suboptimal methods optimizing the splitting ratio for the fixed time-phase and derive a closed-form solution for the suboptimal method based on the power splitting. The results demonstrate that the power splitting approaches outperform their time splitting counterparts and the suboptimal power splitting approach provides a performance close to the optimal one while reducing the complexity significantly.

Two-way portable radios: monitoring exposure to EMF

International Nuclear Information System (INIS)

Aguiar Campos, Maria C.

2008-01-01

Full text: Hand-held two-way portable radios, also known as push-to-talk radios (PTT), radiate intense electromagnetic fields (EMF). Increasingly used for communications inside buildings, these devices should not be neglected as EMF sources in workplace environments. In contrast to mobile-phones, push-to-talk radios usually operate in a lower frequency range (450 < f < 470 MHz), where the reference levels, established by ICNIRP for human exposure, are more restrictive. The intrinsic hazard potential associated to these devices has motivated this assessment of occupational exposure to EMF. In spite of relatively low power levels, usually no more than a few watts, and the intermittency of transmissions, push-to-talk radios are operated close to the body, therefore exposure takes place in the near-field region. Measurements of electromagnetic field intensities were carried out for two push-to-talk models, operating at power levels of 2 W and 5 W, with a broad-band field monitor, EMR-300 (W and G), coupled to an E-field triaxial probe (type 8.0). Intensities were measured at various points surrounding the transmitter, to assess exposure levels of other workers sitting nearby during communications. Results show significant electric field intensities at points less than 10 cm away from the source. A personal monitor with triaxial E and H-field shaped probes, RadMan XT (Narda), was used as a dosimeter by workers operating both radio models, during 8 hours. This device measures E and H-field intensities and stores these values as a percentage of ICNIRP occupational limits, in a data logger. Results of both kind of measurements show that intense EMF are emitted during transmissions. Therefore, workers should be informed about possible EMF hazards and trained to properly operate these transmitters, in order to minimize exposure risks. (author)

ROTRAC electric shunters in two-way technology; ROTRAC-Elektro-Rangierfahrzeuge mit Zweiwege-Technik

Energy Technology Data Exchange (ETDEWEB)

Manthey, Maik [Linde Material Handling GmbH, Aschaffenburg (Germany); Zwiehoff, Stephan [G. Zwiehoff GmbH, Rosenheim (Germany)

2013-03-15

In view of their relatively small size, the remote-controlled ROTRAC electric shunters generate an amazingly high pulling force which is brought about by components known from fork lift truck production. Thanks to the two-way technology applied, the shunters can be easily manoeuvred even between rails. (orig.)

Relative bioequivalence evaluation of two oral atomoxetine hydrochloride capsules: a single dose, randomized, open-label, 2-period crossover study in healthy Chinese volunteers under fasting conditions.

Science.gov (United States)

Shang, D-W; Guo, W; Zhou, F-C; Wang, X-P; Li, A-N; Zhang, L; Li, W-B; Lu, W; Wang, C-Y

2013-11-01

To evaluate the bioequivalence of a new formulation of atomoxetine hydrochloride (CAS 82248-59-7) capsules (test) and an available branded capsules (reference) after administration of a single 40 mg dose, randomized, open-label, 2-period crossover study was conducted in 22 healthy male Chinese subjects with a 1-week wash-out period. This study was designed for/the Honglin Pharmaceutical Co. Ltd and contracted to be done by the Beijing Anding Hospital in order to satisfy Chinese regulatory requirements to allow marketing of this generic product and performed according to the criteria of SFDA. Blood samples were collected before and 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 16 and 24 h after drug administration. Plasma concentrations were determined by high-performance liquid chromatography (HPLC) with UV detection. A non-compartmental method was used to calculate the pharmacokinetic parameters and evaluate bioequivalence of the 2 formulations. The 90% confidence interval (CI) of the ratios (test/reference) of atomoxetine for AUC0-24, AUC0-∞ and Cmax were 100.9% (93.6-108.8%), 103.1% (95.1-111.7%) and 105.2% (92.8-119.4%), respectively, which fell within the interval of 80-125% and 75-133%. No clinically significant changes or abnormalities were noted in laboratory data and vital signs. From these results it can be concluded that the test formulation of atomoxetine capsules met the regulatory criterion for bioequivalence to the reference formulation. © Georg Thieme Verlag KG Stuttgart · New York.

Frequency transfer via a two-way optical phase comparison on a multiplexed fiber network.

Science.gov (United States)

Calosso, C E; Bertacco, E; Calonico, D; Clivati, C; Costanzo, G A; Frittelli, M; Levi, F; Mura, A; Godone, A

2014-03-01

We performed a two-way remote optical phase comparison on optical fiber. Two optical frequency signals were launched in opposite directions in an optical fiber and their phases were simultaneously measured at the other end. In this technique, the fiber noise is passively canceled, and we compared two optical frequencies at the ultimate 10(-21) stability level. The experiment was performed on a 47 km fiber that is part of the metropolitan network for Internet traffic. The technique relies on the synchronous measurement of the optical phases at the two ends of the link, which is here performed by digital electronics. This scheme offers some advantages with respect to active noise cancellation schemes, as the light travels only once in the fiber.

Oral Health-Related Quality of Life in Edentulous Patients with Two- vs Four-Locator-Retained Mandibular Overdentures: A Prospective, Randomized, Crossover Study.

Science.gov (United States)

Karbach, Julia; Hartmann, Sinsa; Jahn-Eimermacher, Antje; Wagner, Wilfried

2015-01-01

To compare the oral health-related quality of life (OHRQoL) in a prospective, randomized crossover trial in patients with mandibular overdentures retained with two or four locators. In 30 patients with edentulous mandibles, four implants (ICX-plus implants [Medentis Medical]) were placed in the intraforaminal area. Eight weeks after transgingival healing, patients were randomly assigned to have two or four implants incorporated in the prosthesis. After 3 months, the retention concepts were switched. The patients with a two-implant-supported overdenture had four implants incorporated, whereas patients with a four-implant-supported overdenture had two retention locators taken out. After 3 more months, all four implants were retained in the implant-supported overdenture in every patient. To measure OHRQoL of the patients, the Oral Health Impact Profile 14, German version (OHIP-14 G), was used. A considerable increase in OHRQoL could be seen in all patients after the prosthesis was placed on the implants. Also, a statistically significant difference of OHRQoL could be seen in the OHIP-14 G scores between two-implant and four-implant overdentures. Patients had a higher OHRQoL after incorporation of four implants in the overdenture compared with only two implants. Patients with implant-retained overdentures had better OHRQoL compared with those with conventional dentures. The number of incorporated implants in the locator-retained overdenture also influenced the increase in OHRQoL, with four implants having a statistically significant advantage over two implants.

A genetic algorithm for multiple relay selection in two-way relaying cognitive radio networks

KAUST Repository

Alsharoa, Ahmad M.; Ghazzai, Hakim; Alouini, Mohamed-Slim

2013-01-01

In this paper, we investigate a multiple relay selection scheme for two-way relaying cognitive radio networks where primary users and secondary users operate on the same frequency band. More specifically, cooperative relays using Amplifyand- Forward

Eavesdropping on the two-way quantum communication protocols with invisible photons

Energy Technology Data Exchange (ETDEWEB)

Cai Qingyu [State Key Laboratory of Magnetics Resonance and Atomic and Molecular Physics, Wuhan Institution of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071 (China)]. E-mail: qycai@wipm.ac.cn

2006-02-20

The crucial issue of quantum communication protocol is its security. In this Letter, we show that all the deterministic and direct two-way quantum communication protocols, sometimes called ping-pong (PP) protocols, are insecure when an eavesdropper uses the invisible photon to eavesdrop on the communication. With our invisible photon eavesdropping (IPE) scheme, the eavesdropper can obtain full information of the communication with zero risk of being detected. We show that this IPE scheme can be implemented experimentally with current technology. Finally, a possible improvement of PP communication protocols security is proposed00.

Eavesdropping on the two-way quantum communication protocols with invisible photons

International Nuclear Information System (INIS)

Cai Qingyu

2006-01-01

The crucial issue of quantum communication protocol is its security. In this Letter, we show that all the deterministic and direct two-way quantum communication protocols, sometimes called ping-pong (PP) protocols, are insecure when an eavesdropper uses the invisible photon to eavesdrop on the communication. With our invisible photon eavesdropping (IPE) scheme, the eavesdropper can obtain full information of the communication with zero risk of being detected. We show that this IPE scheme can be implemented experimentally with current technology. Finally, a possible improvement of PP communication protocols security is proposed

A novel two-way-controllable magneto-rheological fluid damper

International Nuclear Information System (INIS)

Aydar, Gokhan; Wang, Xiaojie; Gordaninejad, Faramarz

2010-01-01

In this paper, a disc type, radial flow-mode magneto-rheological (MR) fluid damper comprising a permanent magnet and an electromagnet is designed, built and tested. The proposed MR fluid damper has an MR valve with which two-way controllability through cancellation or enhancement of the magnetic field is obtained. This added feature provides damping forces less than or greater than that of a passive viscous original equipment manufacturer damper. A three-dimensional electromagnetic finite element analysis has been performed to realize this unique function in the proposed design. Experimental and theoretical studies have been conducted in order to demonstrate that this new design can provide softer damping properties by cancelling the effect of the permanent magnet, while at the same time enhancing the field effect, resulting in a harder damping device. Softer and harder damping refer to decrease and increase in the damping, respectively

Evaluation of two novel tablet formulations of artemether-lumefantrine (Coartem) for bioequivalence in a randomized, open-label, two-period study.

Science.gov (United States)

Lefèvre, Gilbert; Bhad, Prafulla; Jain, Jay Prakash; Kalluri, Sampath; Cheng, Yi; Dave, Hardik; Stein, Daniel S

2013-09-08

Artemether-lumefantrine (Coartem; AL) is a standard of care for malaria treatment as an oral six-dose regimen, given twice daily over three days with one to four tablets (20/120 mg) per dose, depending on patient body weight. In order to reduce the pill burden at each dose and potentially enhance compliance, two novel fixed-dose tablet formulations (80/480 mg and 60/360 mg) have been developed and tested in this study for bioequivalence with their respective number of standard tablets. A randomized, open-label, two-period, single-dose, within formulation crossover bioequivalence study comparing artemether and lumefantrine exposure between the novel 80/480 mg tablet and four standard tablets, and the novel 60/360 mg tablet and three standard tablets, was conducted in 120 healthy subjects under fed conditions. Artemether, dihydroartemisinin, and lumefantrine were measured in plasma by HPLC/UPLC-MS/MS. Pharmacokinetic (PK) parameters were determined by non-compartmental analyses. Adjusted geometric mean AUClast for artemether were 345 and 364 ng·h/mL (geometric mean ratio (GMR) 0.95; 90% CI 0.89-1.01) and for lumefantrine were 219 and 218 μg·h/mL (GMR 1.00; 90% CI 0.93-1.08) for 80/480 mg tablet versus four standard tablets, respectively. Corresponding Cmax for artemether were 96.8 and 99.7 ng/mL (GMR 0.97; 90% CI 0.89-1.06) and for lumefantrine were 8.42 and 8.71 μg/mL (GMR 0.97; 90% CI 0.89-1.05). For the 60/360 mg tablet versus three standard tablets, adjusted geometric mean AUClast for artemether were 235 and 231 ng·h/mL (GMR 1.02; 90% CI 0.94-1.10), and for lumefantrine were 160 and 180 μg·h/mL (GMR 0.89; 90% CI 0.83-0.96), respectively. Corresponding Cmax for artemether were 75.5 and 71.5 ng/mL (GMR 1.06; 90% CI 0.95-1.18), and for lumefantrine were 6.64 and 7.61 μg/mL (GMR 0.87; 90% CI 0.81-0.94), respectively. GMR for Cmax and AUClast for artemether and lumefantrine for all primary comparisons were within the bioequivalence acceptance criteria (0

Translanguaging and Positioning in Two-Way Dual Language Classrooms: A Case for Criticality

Science.gov (United States)

Hamman, Laura

2018-01-01

This article examines the role of translanguaging practices and pedagogies in two-way dual language classrooms. Much of the recent expansion of dual language programs across the US has occurred in mid-sized cities and rural communities where English monolingualism is the norm; however, the extant literature on flexible language practices in…

Diabetes and hepatitis C : A two-way association

Directory of Open Access Journals (Sweden)

Sara Salehi Hammerstad

2015-09-01

Full Text Available Diabetes and hepatitis C infection are both prevalent diseases worldwide, and are associated with increased morbidity and mortality. Most studies, but not all, have shown that patients with chronic hepatitis C are more prone to develop type 2 diabetes compared to healthy controls, as well as when compared to patients with other liver diseases including hepatitis B. Furthermore, epidemiological studies have revealed that patients with type 2 diabetes may also be at higher risk for worse outcomes of their hepatitis C infection, including reduced rate of sustained virologic response, progression to fibrosis and cirrhosis, and higher risk for development of hepatocellular carcinoma. Moreover, hepatitis C infection and mainly its treatment, interferon α, can trigger the development of type 1 diabetes. In this review we discuss the existing data on this two-way association between diabetes and hepatitis C infection with emphasis on possible mechanisms. It remains to be determined whether the new curative therapies for chronic hepatitis C will improve outcomes in diabetic hepatitis C patients, and conversely whether treatment with Metformin will reduce complications from HCV infection. We propose an algorithm for diabetes screening and follow-up in hepatitis C patients.

TWO NEW LONG-PERIOD HOT SUBDWARF BINARIES WITH DWARF COMPANIONS

Energy Technology Data Exchange (ETDEWEB)

Barlow, Brad N.; Wade, Richard A. [Department of Astronomy and Astrophysics, Pennsylvania State University, 525 Davey Lab, University Park, PA 16802 (United States); Liss, Sandra E. [Department of Astronomy, University of Virginia, P.O. Box 400325, Charlottesville, VA 22904-4325 (United States); Green, Elizabeth M., E-mail: bbarlow@psu.edu [Steward Observatory, University of Arizona, 933 N. Cherry Avenue, Tucson, AZ 85721 (United States)

2013-07-01

Hot subdwarf stars with F-K main sequence binary companions have been known for decades, but the first orbital periods for such systems were published just recently. Current observations suggest that most have long periods, on the order of years, and that some are or once were hierarchical triple systems. As part of a survey with the Hobby-Eberly Telescope, we have been monitoring the radial velocities of several composite-spectra binaries since 2005 in order to determine their periods, velocities, and eccentricities. Here we present observations and orbital solutions for two of these systems, PG 1449+653 and PG 1701+359. Similar to the other sdB+F/G/K binaries with solved orbits, their periods are long, 909 and 734 days, respectively, and pose a challenge to current binary population synthesis models of hot subdwarf stars. Intrigued by their relatively large systemic velocities, we also present a kinematical analysis of both targets and find that neither is likely a member of the Galactic thin disk.

TWO NEW LONG-PERIOD HOT SUBDWARF BINARIES WITH DWARF COMPANIONS

International Nuclear Information System (INIS)

Barlow, Brad N.; Wade, Richard A.; Liss, Sandra E.; Green, Elizabeth M.

2013-01-01

Hot subdwarf stars with F-K main sequence binary companions have been known for decades, but the first orbital periods for such systems were published just recently. Current observations suggest that most have long periods, on the order of years, and that some are or once were hierarchical triple systems. As part of a survey with the Hobby-Eberly Telescope, we have been monitoring the radial velocities of several composite-spectra binaries since 2005 in order to determine their periods, velocities, and eccentricities. Here we present observations and orbital solutions for two of these systems, PG 1449+653 and PG 1701+359. Similar to the other sdB+F/G/K binaries with solved orbits, their periods are long, 909 and 734 days, respectively, and pose a challenge to current binary population synthesis models of hot subdwarf stars. Intrigued by their relatively large systemic velocities, we also present a kinematical analysis of both targets and find that neither is likely a member of the Galactic thin disk.

Quantum hacking of two-way continuous-variable quantum key distribution using Trojan-horse attack

Science.gov (United States)

Ma, Hong-Xin; Bao, Wan-Su; Li, Hong-Wei; Chou, Chun

2016-08-01

We present a Trojan-horse attack on the practical two-way continuous-variable quantum key distribution system. Our attack mainly focuses on the imperfection of the practical system that the modulator has a redundancy of modulation pulse-width, which leaves a loophole for the eavesdropper inserting a Trojan-horse pulse. Utilizing the unique characteristics of two-way continuous-variable quantum key distribution that Alice only takes modulation operation on the received mode without any measurement, this attack allows the eavesdropper to render all of the final keys shared between the legitimate parties insecure without being detected. After analyzing the feasibility of the attack, the corresponding countermeasures are put forward. Project supported by the National Basic Research Program of China (Grant No. 2013CB338002) and the National Natural Science Foundation of China (Grant Nos. 11304397 and 61505261).

One-way quantum computation via manipulation of polarization and momentum qubits in two-photon cluster states

International Nuclear Information System (INIS)

Vallone, G; Pomarico, E; De Martini, F; Mataloni, P

2008-01-01

Four-qubit cluster states of two photons entangled in polarization and linear momentum have been used to realize a complete set of single qubit rotations and the C-NOT gate for equatorial qubits with high values of fidelity. By the computational equivalence of the two degrees of freedom our result demonstrate the suitability of two photon cluster states for rapid and efficient one-way quantum computing

Distributed cognitive two-way relay beamformer designs under perfect and imperfect CSI

KAUST Repository

Pandarakkottilil, Ubaidulla

2011-09-01

In this paper, we present distributed two-way relay beamformer designs for a cognitive radio network (CRN) in which a pair of cognitive (or secondary) transceiver nodes communicate with each other assisted by a set of cognitive two-way relay nodes. The secondary nodes share the spectrum with a licensed primary user (PU) node, and each node is assumed to be equipped with a single transmit/receive antenna. The interference to the PU resulting from the transmission from the cognitive nodes is kept below a specified limit. First, we consider relay beamformer designs assuming the availability of perfect channel state information (CSI). For this case, a mean-square error (MSE)-constrained beamformer that minimizes the total relay transmit power, and an MSE-balancing beamformer with a constraint on the total relay transmit power are proposed. Next, we consider relay beamformer designs assuming that the available CSI is imperfect. For this case too, we consider the same problems as those in the case of perfect CSI, and propose beamformer designs that are robust to the errors in the CSI. We show that the proposed designs can be reformulated as convex optimization problems that can be solved efficiently. Through numerical simulations, we illustrate the performance of the proposed designs. © 2011 IEEE.

Two-Way Social Media Messaging in Postoperative Cataract Surgical Patients: Prospective Interventional Study.

Science.gov (United States)

Sanguansak, Thuss; Morley, Katharine E; Morley, Michael G; Thinkhamrop, Kavin; Thuanman, Jaruwan; Agarwal, Isha

2017-12-19

Social media offers a new way to provide education, reminders, and support for patients with a variety of health conditions. Most of these interventions use one-way, provider-patient communication. Incorporating social media tools to improve postoperative (postop) education and follow-up care has only been used in limited situations. The aim of this study was to determine the feasibility and efficacy of two-way social media messaging to deliver reminders and educational information about postop care to cataract patients. A total of 98 patients undergoing their first eye cataract surgery were divided into two groups: a no message group receiving usual pre- and postop care and a message group receiving usual care plus messages in a mobile social media format with standardized content and timing. Each patient in the message group received nine messages about hand and face hygiene, medication and postop visit adherence, and links to patient education videos about postop care. Patients could respond to messages as desired. Main outcome measures included medication adherence, postop visit adherence, clinical outcomes, and patients' subjective assessments of two-way messaging. The number, types, content, and timing of responses by patients to messages were recorded. Medication adherence was better in the message group at postop day 7, with high adherence in 47 patients (96%, 47/49) versus 36 patients (73%, 36/49) in the no message group (P=.004), but no statistically significant differences in medication adherence between the groups were noted at preop and postop day 30. Visit adherence was higher at postop day 30 in the message group (100%, 49/49) versus the no message group (88%, 43/49; P=.03) but was 100% (49/49) in both groups at postop day 1 and 7. Final visual outcomes were similar between groups. A total of 441 standardized messages were sent to the message group. Out of 270 responses generated, 188 (70%) were simple acknowledgments or "thank you," and 82 (30

Impact of I/Q imbalance on the performance of two-way CSI-assisted AF relaying

KAUST Repository

Qi, Jian; Aï ssa, Sonia; Alouini, Mohamed-Slim

2013-01-01

In this paper, we investigate half-duplex two-way dual-hop channel state information (CSI)-assisted amplify-and-forward (AF) relaying in the presence of in-phase and quadrature-phase (I/Q) imbalance. A compensation approach for the I/Q imbalance is proposed, which employs the received signals together with their conjugations to detect the desired signal. We also derive the average symbol error probability of the considered half-duplex two-way dual-hop CSI-assisted AF relaying networks with and without compensation for I/Q imbalance in Rayleigh fading channels. Numerical results are provided and show that the proposed compensation method mitigates the impact of I/Q imbalance to a certain extent. © 2013 IEEE.

Impact of I/Q imbalance on the performance of two-way CSI-assisted AF relaying

KAUST Repository

Qi, Jian

2013-04-01

In this paper, we investigate half-duplex two-way dual-hop channel state information (CSI)-assisted amplify-and-forward (AF) relaying in the presence of in-phase and quadrature-phase (I/Q) imbalance. A compensation approach for the I/Q imbalance is proposed, which employs the received signals together with their conjugations to detect the desired signal. We also derive the average symbol error probability of the considered half-duplex two-way dual-hop CSI-assisted AF relaying networks with and without compensation for I/Q imbalance in Rayleigh fading channels. Numerical results are provided and show that the proposed compensation method mitigates the impact of I/Q imbalance to a certain extent. © 2013 IEEE.

Third Space Openings at a Two-Way Immersion Elementary School in North Carolina: Lessons from Parent Language Classes

Science.gov (United States)

Turner, Alison M.

2016-01-01

Two-way immersion schools are growing in popularity throughout the United States. An emerging issue is to what extent these schools are able to connect with parents from multiple communities. This article describes an effort to connect parents with the school and one another through parent language classes at a Spanish/English two-way immersion…

Two-way shape memory behavior of shape memory polyurethanes with a bias load

International Nuclear Information System (INIS)

Hong, Seok Jin; Yu, Woong-Ryeol; Youk, Ji Ho

2010-01-01

Thermo-responsive shape memory polyurethane (SMPU) is a smart material that can respond to external heat by changing its macroscopic shape from a temporary configuration to a memorized permanent one. The temporary shape can be processed using mechanical forces above a certain temperature (the transition temperature) and can be maintained until the material acquires a certain thermal energy. Thereafter, the material will recover its memorized permanent shape. However, it is unclear what will occur if the thermal energy is then dissipated, i.e., the material temperature decreases. There are two possibilities: the material will respond to the dissipated energy, resulting in another macroscopic shape change; or nothing will happen beyond the thermal contraction. The former is called two-way shape memory (TWSM) behavior and the latter is called one-way shape memory behavior. This paper reports novel findings showing that TWSM behavior can be imparted to SMPUs using a thermo-mechanical treatment, i.e., imposing a constant stress on them after their temporary shaping. A series of experiments were carried out to characterize the TWSM behavior of SMPUs and to explain its mechanism

Key rate of quantum key distribution with hashed two-way classical communication

International Nuclear Information System (INIS)

Watanabe, Shun; Matsumoto, Ryutaroh; Uyematsu, Tomohiko; Kawano, Yasuhito

2007-01-01

We propose an information reconciliation protocol that uses two-way classical communication. The key rates of quantum key distribution (QKD) protocols that use our protocol are higher than those using previously known protocols for a wide range of error rates for the Bennett-Brassard 1984 and six-state protocols. We also clarify the relation between the proposed and known QKD protocols, and the relation between the proposed protocol and entanglement distillation protocols

Two Ways of Learning Brand Associations

NARCIS (Netherlands)

S.M.J. van Osselaer (Stijn); C. Janiszewski (Chris)

2001-01-01

textabstractFour studies show that consumers have not one but two distinct learning processes that allow them to use brand names and other product features to predict consumption benefits. The first learning process is a relatively unfocused process in which all stimulus elements get

Inter-hospital communications and transport: turning one-way funnels into two-way networks.

Science.gov (United States)

Rokos, Ivan C; Sanddal, Nels D; Pancioli, Arthur M; Wolff, Catherine; Gaieski, David F

2010-12-01

The Inter-hospital Communications and Transport workgroup was charged with exploring the current status, barriers, and data necessary to optimize the initial destination and subsequent transfer of patients between and among acute care settings. The subtitle, "Turning Funnels Into Two-way Networks," is descriptive of the approach that the workgroup took by exploring how and when smaller facilities in suburban, rural, and frontier areas can contribute to the daily business of caring for emergency patients across the lower-acuity spectrum-in some instances with consultant support from academic medical centers. It also focused on the need to identify high-acuity patients and expedite triage and transfer of those patients to facilities with specialty resources. Draft research recommendations were developed through an iterative writing process and presented to a breakout session of Academic Emergency Medicine's 2010 consensus conference, "Beyond Regionalization: Integrated Networks of Emergency Care." Priority research areas were determined by informal consensus of the breakout group. A subsequent iterative writing process was undertaken to complete this article. A number of broad research questions are presented. 2010 by the Society for Academic Emergency Medicine.

Contrasted patterns of crossover and non-crossover at Arabidopsis thaliana meiotic recombination hotspots.

Directory of Open Access Journals (Sweden)

Jan Drouaud

2013-11-01

Full Text Available The vast majority of meiotic recombination events (crossovers (COs and non-crossovers (NCOs cluster in narrow hotspots surrounded by large regions devoid of recombinational activity. Here, using a new molecular approach in plants, called "pollen-typing", we detected and characterized hundreds of CO and NCO molecules in two different hotspot regions in Arabidopsis thaliana. This analysis revealed that COs are concentrated in regions of a few kilobases where their rates reach up to 50 times the genome average. The hotspots themselves tend to cluster in regions less than 8 kilobases in size with overlapping CO distribution. Non-crossover (NCO events also occurred in the two hotspots but at very different levels (local CO/NCO ratios of 1/1 and 30/1 and their track lengths were quite small (a few hundred base pairs. We also showed that the ZMM protein MSH4 plays a role in CO formation and somewhat unexpectedly we also found that it is involved in the generation of NCOs but with a different level of effect. Finally, factors acting in cis and in trans appear to shape the rate and distribution of COs at meiotic recombination hotspots.

A comparative study of two-piece ostomy appliances.

Science.gov (United States)

Welser, Marion; Riedlinger, Inge; Prause, Ulla

The quality of life of people with a stoma may be affected by peristomal skin disorders and by frequent unplanned changes of ostomy appliances due to problems with those appliances. The aim of this study was to evaluate two new, two-piece ostomy appliances with mechanical couplings (both from the SenSura range by Coloplast) and their ability to address areas that may be important to the quality of life of people with stomas, including appliance changes, stool seepage and overfilling. The study design featured two comparative, crossover, randomized multi-centre studies that were conducted in Germany. The SenSura appliances were evaluated against established reference appliances. Seventy-three individuals with a colostomy (closed-end appliances) and 75 individuals with an ileostomy (drainable appliances) participated in the studies. The participants tested 4-6 flanges of each type within a maximum period of two weeks. The results demonstrated that there was less seepage of stool observed under the SenSura flange when it was removed (pappliances. The SenSura flanges had better adhesion and flexibility and were easier to remove than the references (pappliances on quality of life indicators - there were fewer unplanned changes and less seepage of stool was observed in patients using the SenSura products.

Extended precedence preservative crossover for job shop scheduling problems

Science.gov (United States)

Ong, Chung Sin; Moin, Noor Hasnah; Omar, Mohd

2013-04-01

Job shop scheduling problems (JSSP) is one of difficult combinatorial scheduling problems. A wide range of genetic algorithms based on the two parents crossover have been applied to solve the problem but multi parents (more than two parents) crossover in solving the JSSP is still lacking. This paper proposes the extended precedence preservative crossover (EPPX) which uses multi parents for recombination in the genetic algorithms. EPPX is a variation of the precedence preservative crossover (PPX) which is one of the crossovers that perform well to find the solutions for the JSSP. EPPX is based on a vector to determine the gene selected in recombination for the next generation. Legalization of children (offspring) can be eliminated due to the JSSP representation encoded by using permutation with repetition that guarantees the feasibility of chromosomes. The simulations are performed on a set of benchmarks from the literatures and the results are compared to ensure the sustainability of multi parents recombination in solving the JSSP.

Double-Blind Crossover Study to Compare Pain Experience During Inferior Alveolar Nerve Block Administration Using Buffered Two Percent Lidocaine in Children.

Science.gov (United States)

Chopra, Radhika; Jindal, Garima; Sachdev, Vinod; Sandhu, Meera

2016-01-01

Buffering of anesthetic solutions has been suggested to reduce pain on injection and onset of anesthesia. The purpose of this study was to assess the reduction in pain on injection during inferior alveolar nerve block administration in children. A double blind crossover study was designed where 30 six- to 12-year-old patients received two sessions of inferior alveolar nerve block scheduled one week apart. Two percent lidocaine with 1:200,000 epinephrine was given during one appointment, and a buffered solution was given during the other. Pain on injection was assessed using the sound, eye, and motor (SEM) scale, and the time to onset was assessed after gingival probing. The Heft-Parker visual analogue scale (HP-VAS) was self recorded by the patient after administration of local anesthesia. When tested using Mann-Whitney analysis, no significant differences were found between the SEM scores (P=0.71) and HP-VAS scores (P=0.93) for the two solutions used. Student's t test was used to assess the difference in the onset of anesthesia, which was also found to be statistically insignificant (P=0.824). Buffered lidocaine did not reduce the pain on injection or time to onset of anesthesia for inferior alveolar nerve block in children.

Relay selection and resource allocation for two-way DF-AF cognitive radio networks

KAUST Repository

Alsharoa, Ahmad M.; Bader, Faouzi; Alouini, Mohamed-Slim

2013-01-01

In this letter, the problem of relay selection and optimal resource allocation for two-way relaying cognitive radio networks using half duplex amplify-and-forward and decode-and-forward protocols is investigated. The primary and secondary users are assumed to access the spectrum simultaneously, in a way that the interference introduced to the primary users should be below a certain tolerated limit. Dual decomposition and subgradient methods are used to find the optimal power allocation. A suboptimal approach based on a genetic algorithm is also presented. Simulation results show that the proposed suboptimal algorithm offers a performance close to the optimal performance with a considerable complexity saving. © 2013 IEEE.

Relay selection and resource allocation for two-way DF-AF cognitive radio networks

KAUST Repository

Alsharoa, Ahmad M.

2013-08-01

In this letter, the problem of relay selection and optimal resource allocation for two-way relaying cognitive radio networks using half duplex amplify-and-forward and decode-and-forward protocols is investigated. The primary and secondary users are assumed to access the spectrum simultaneously, in a way that the interference introduced to the primary users should be below a certain tolerated limit. Dual decomposition and subgradient methods are used to find the optimal power allocation. A suboptimal approach based on a genetic algorithm is also presented. Simulation results show that the proposed suboptimal algorithm offers a performance close to the optimal performance with a considerable complexity saving. © 2013 IEEE.

EEG/MEG Source Reconstruction with Spatial-Temporal Two-Way Regularized Regression

KAUST Repository

Tian, Tian Siva

2013-07-11

In this work, we propose a spatial-temporal two-way regularized regression method for reconstructing neural source signals from EEG/MEG time course measurements. The proposed method estimates the dipole locations and amplitudes simultaneously through minimizing a single penalized least squares criterion. The novelty of our methodology is the simultaneous consideration of three desirable properties of the reconstructed source signals, that is, spatial focality, spatial smoothness, and temporal smoothness. The desirable properties are achieved by using three separate penalty functions in the penalized regression framework. Specifically, we impose a roughness penalty in the temporal domain for temporal smoothness, and a sparsity-inducing penalty and a graph Laplacian penalty in the spatial domain for spatial focality and smoothness. We develop a computational efficient multilevel block coordinate descent algorithm to implement the method. Using a simulation study with several settings of different spatial complexity and two real MEG examples, we show that the proposed method outperforms existing methods that use only a subset of the three penalty functions. © 2013 Springer Science+Business Media New York.

Outage performance of two-way DF relaying systems with a new relay selection metric

KAUST Repository

Hyadi, Amal

2012-04-01

This paper investigates a new constrained relay selection scheme for two-way relaying systems where two end terminals communicate simultaneously via a relay. The introduced technique is based on the maximization of the weighted sum rate of both users. To evaluate the performance of the proposed system, the outage probability is derived in a general case (where an arbitrary channel is considered), and then over independently but not necessarily identically distributed (i.n.i.d.) Rayleigh fading channels. The analytical results are verified through simulations. © 2012 IEEE.

Inventories and Endogenous Stackelberg Leadership in Two-period Cournot Oligopoly

OpenAIRE

Mitraille, Sébastien; Moreaux, Michel

2012-01-01

Two-period Cournot competition between n identical firms producing at constant marginal cost and able to store before selling has pure strategy Nash- perfect equilibria, in which some firms store to exert endogenously a leader- ship over rivals. The number of firms storing balances market share gains, obtained by accumulating early the output, with losses in margin resulting from increased competition and higher operation costs. This number and the industry inventories are non monotonic in...

Two-echelon competitive integrated supply chain model with price and credit period dependent demand

Science.gov (United States)

Pal, Brojeswar; Sankar Sana, Shib; Chaudhuri, Kripasindhu

2016-04-01

This study considers a two-echelon competitive supply chain consisting of two rivaling retailers and one common supplier with trade credit policy. The retailers hope that they can enhance their market demand by offering a credit period to the customers and the supplier also offers a credit period to the retailers. We assume that the market demand of the products of one retailer depends not only on their own market price and offering a credit period to the customers, but also on the market price and offering a credit period of the other retailer. The supplier supplies the product with a common wholesale price and offers the same credit period to the retailers. We study the model under a centralised (integrated) case and a decentralised (Vertical Nash) case and compare them numerically. Finally, we investigate the model by the collected numerical data.

Anti-Money Laundry regulation and Crime: A two-period model of money-in-the-utility-function

OpenAIRE

Fanta, F; Mohsin, H

2010-01-01

The paper presents a two period model with two types of money i.e. dirty and cleans (legal) money in utility function. Clean money is earned from working in legal sector and dirty from illegal sector. Our two-two period model reveals that an increase in labor wage in legal sector unambiguously decease the labor hours allocated for illegal sector by increasing the opportunity cost for illegal activities. However, the crime-reducing impact of anti-money laundry regulation and the probability of...

Two-phase 1D+1D model of a DMFC: development and validation on extensive operating conditions range

Energy Technology Data Exchange (ETDEWEB)

Casalegno, A.; Marchesi, R.; Parenti, D. [Dipartimento di Energetica, Politecnico di Milano (Italy)

2008-02-15

A two-phase 1D+1D model of a direct methanol fuel cell (DMFC) is developed, considering overall mass balance, methanol transport in gas phase through anode diffusion layer, methanol and water crossover. The model is quantitatively validated on an extensive range of operating conditions, 24 polarisation curves. The model accurately reproduces DMFC performance in the validation range and, outside this, it is able to predict values under feasible operating conditions. Finally, the estimations of methanol crossover flux are qualitatively and quantitatively similar to experimental measures and the main local quantities' trends are coherent with results obtained with more complex models. (Abstract Copyright [2008], Wiley Periodicals, Inc.)

Periodic, quasiperiodic, and chaotic breathers in two-dimensional discrete β-Fermi—Pasta—Ulam lattice

International Nuclear Information System (INIS)

Xu Quan; Tian Qiang

2013-01-01

Using numerical method, we investigate whether periodic, quasiperiodic, and chaotic breathers are supported by the two-dimensional discrete Fermi—Pasta—Ulam (FPU) lattice with linear dispersion term. The spatial profile and time evolution of the two-dimensional discrete β-FPU lattice are segregated by the method of separation of variables, and the numerical simulations suggest that the discrete breathers (DBs) are supported by the system. By introducing a periodic interaction into the linear interaction between the atoms, we achieve the coupling of two incommensurate frequencies for a single DB, and the numerical simulations suggest that the quasiperiodic and chaotic breathers are supported by the system, too. (condensed matter: structural, mechanical, and thermal properties)

Cost analysis of two-dimensional warranty for products with periodic preventive maintenance

International Nuclear Information System (INIS)

Huang, Yeu-Shiang; Gau, Wei-Yo; Ho, Jyh-Wen

2015-01-01

This study uses a bivariate approach, which simultaneously considers the time and usage of a repairable product, and takes into account periodic preventive maintenance to develop a two-dimensional warranty policy for the repairable product. The proposed model is based on the bivariate Weibull process to analyze the breakdown process of a repairable product simultaneously in terms of time and usage. A repairable product may be differently utilized by various customers. We consider two types of customers: (1) customers whose product warranty is terminated because the warranty time limit has reached first; (2) customers whose product warranty is terminated because the warranty usage limit has reached first, to perform cost analyses for determining an appropriate warranty policy. However, since it is often the case that the repairable product may be equally likely purchased by the two types of customers who are equivalently important to the product manufacturer; the optimal warranty policy would thus be the equilibrium solution of the cost analyses which pay the same attention to both types of customers in order to maximize the total profit of the manufacturer. - Highlights: • We use a bivariate method to model the breakdown process. • We consider a periodic PM schedule. • We obtain an optimal two-dimensional warranty policy considering various customers. • The optimal 2D warranty is an equilibrium which satisfies both seller and buyer

Bandwidth and power allocation for two-way relaying in overlay cognitive radio systems

KAUST Repository

Alsharoa, Ahmad M.

2014-12-01

In this paper, the problem of both bandwidth and power allocation for two-way multiple relay systems in overlay cognitive radio (CR) setup is investigated. In the CR overlay mode, primary users (PUs) cooperate with cognitive users (CUs) for mutual benefits. In our framework, we propose that the CUs are allowed to allocate a part of the PUs spectrum to perform their cognitive transmission. In return, acting as an amplify-and-forward two-way relays, they are used to support PUs to achieve their target data rates over the remaining bandwidth. More specifically, CUs acts as relays for the PUs and gain some spectrum as long as they respect a specific power budget and primary quality-of-service constraints. In this context, we first derive closed-form expressions for optimal transmit power allocated to PUs and CUs in order to maximize the cognitive objective. Then, we employ a strong optimization tool based on particle swarm optimization algorithm to find the optimal relay amplification gains and optimal cognitive released bandwidths as well. Our numerical results illustrate the performance of our proposed algorithm for different utility metrics and analyze the impact of some system parameters on the achieved performance.

An Intervention with Mineral Water Decreases Cardiometabolic Risk Biomarkers. A Crossover, Randomised, Controlled Trial with Two Mineral Waters in Moderately Hypercholesterolaemic Adults

Directory of Open Access Journals (Sweden)

Laura Toxqui

2016-06-01

Full Text Available Water intake is essential for health maintenance and disease prevention. The effects of an intervention with two mineral waters, sodium-bicarbonated mineral water (BW or control mineral water low in mineral content (CW, on cardiometabolic risk biomarkers were studied. In a randomised-controlled crossover-trial, sixty-four moderately hypercholesterolaemic adults were randomly assigned to consume 1 L/day of either BW (sodium, 1 g/L; bicarbonate, 2 g/L or CW with the main meals for eight weeks, separated by an eight-week washout period. Blood lipids, lipid oxidation, glucose, insulin, aldosterone, urine pH, urinary electrolytes, blood pressure, body weight, fluid intake, energy, and nutrients from total diet and beverages were determined. Total cholesterol, LDL cholesterol, and glucose decreased (p < 0.01, oxidised LDL tended to decrease (p = 0.073, and apolipoprotein B increased during the intervention, without water type effect. Energy and carbohydrates from beverages decreased since soft drinks and fruit juice consumptions decreased throughout the trial. BW increased urinary pH (p = 0.006 and reduced calcium/creatinine excretion (p = 0.011. Urinary potassium/creatinine decreased with both waters. Consumption of 1 L/day of mineral water with the main meals reduces cardiometabolic risk biomarkers, likely to be attributed to a replacement of soft drinks by water. In addition, BW does not affect blood pressure and exerts a moderate alkalizing effect in the body.

Symmetric extension of bipartite quantum states and its use in quantum key distribution with two-way postprocessing

Energy Technology Data Exchange (ETDEWEB)

Myhr, Geir Ove

2010-11-08

Just like we can divide the set of bipartite quantum states into separable states and entangled states, we can divide it into states with and without a symmetric extension. The states with a symmetric extension - which includes all the separable states - behave classically in many ways, while the states without a symmetric extension - which are all entangled - have the potential to exhibit quantum effects. The set of states with a symmetric extension is closed under local quantum operations assisted by one-way classical communication (1-LOCC) just like the set of separable states is closed under local operations assisted by two-way classical communication (LOCC). Because of this, states with a symmetric extension often play the same role in a one-way communication setting as the separable states play in a two-way communication setting. We show that any state with a symmetric extension can be decomposed into a convex combination of states that have a pure symmetric extension. A necessary condition for a state to have a pure symmetric extension is that the spectra of the local and global density matrices are equal. This condition is also sufficient for two qubits, but not for any larger systems. We present a conjectured necessary and sufficient condition for two-qubit states with a symmetric extension. Proofs are provided for some classes of states: rank-two states, states on the symmetric subspace, Bell-diagonal states and states that are invariant under S x S, where S is a phase gate. We also show how the symmetric extension problem for multi-qubit Bell-diagonal states can be simplified and the simplified problem implemented as a semidefinite program. Quantum key distribution protocols such as the six-state protocol and the BB84 protocol effectively gives Alice and Bob Bell-diagonal states that they measure in the standard basis to obtain a raw key which they may then process further to obtain a secret error-free key. When the raw key has a high error rate, the

Symmetric extension of bipartite quantum states and its use in quantum key distribution with two-way postprocessing

International Nuclear Information System (INIS)

Myhr, Geir Ove

2010-01-01

Just like we can divide the set of bipartite quantum states into separable states and entangled states, we can divide it into states with and without a symmetric extension. The states with a symmetric extension - which includes all the separable states - behave classically in many ways, while the states without a symmetric extension - which are all entangled - have the potential to exhibit quantum effects. The set of states with a symmetric extension is closed under local quantum operations assisted by one-way classical communication (1-LOCC) just like the set of separable states is closed under local operations assisted by two-way classical communication (LOCC). Because of this, states with a symmetric extension often play the same role in a one-way communication setting as the separable states play in a two-way communication setting. We show that any state with a symmetric extension can be decomposed into a convex combination of states that have a pure symmetric extension. A necessary condition for a state to have a pure symmetric extension is that the spectra of the local and global density matrices are equal. This condition is also sufficient for two qubits, but not for any larger systems. We present a conjectured necessary and sufficient condition for two-qubit states with a symmetric extension. Proofs are provided for some classes of states: rank-two states, states on the symmetric subspace, Bell-diagonal states and states that are invariant under S x S, where S is a phase gate. We also show how the symmetric extension problem for multi-qubit Bell-diagonal states can be simplified and the simplified problem implemented as a semidefinite program. Quantum key distribution protocols such as the six-state protocol and the BB84 protocol effectively gives Alice and Bob Bell-diagonal states that they measure in the standard basis to obtain a raw key which they may then process further to obtain a secret error-free key. When the raw key has a high error rate, the

Extra virgin olive oil phenols and markers of oxidation in Greek smokers: a randomized cross-over study

NARCIS (Netherlands)

Moschandreas, J.; Vissers, M.N.; Wiseman, S.; Putte, van K.P.; Kafatos, A.

2002-01-01

Objective: To examine the effect of a low phenol olive oil and high phenol olive oil on markers of oxidation and plasma susceptibility to oxidation in normolipaemic smokers. Design: Randomized single-blind cross-over trial with two intervention periods. Setting: The Medical School and University

PERIODIC REVIEW SYSTEM FOR INVENTORY REPLENISHMENT CONTROL FOR A TWO-ECHELON LOGISTICS NETWORK UNDER DEMAND UNCERTAINTY: A TWO-STAGE STOCHASTIC PROGRAMING APPROACH

OpenAIRE

Cunha, P.S.A.; Oliveira, F.; Raupp, Fernanda M.P.

2017-01-01

ABSTRACT Here, we propose a novel methodology for replenishment and control systems for inventories of two-echelon logistics networks using a two-stage stochastic programming, considering periodic review and uncertain demands. In addition, to achieve better customer services, we introduce a variable rationing rule to address quantities of the item in short. The devised models are reformulated into their deterministic equivalent, resulting in nonlinear mixed-integer programming models, which a...

Two-way QKD with single-photon-added coherent states

Science.gov (United States)

Miranda, Mario; Mundarain, Douglas

2017-12-01

In this work we present a two-way quantum key distribution (QKD) scheme that uses single-photon-added coherent states and displacement operations. The first party randomly sends coherent states (CS) or single-photon-added coherent states (SPACS) to the second party. The latter sends back the same state it received. Both parties decide which kind of states they are receiving by detecting or not a photon on the received signal after displacement operations. The first party must determine whether its sent and received states are equal; otherwise, the case must be discarded. We are going to show that an eavesdropper provided with a beam splitter gets the same information in any of the non-discarded cases. The key can be obtained by assigning 0 to CS and 1 to SPACS in the non-discarded cases. This protocol guarantees keys' security in the presence of a beam splitter attack even for states with a high number of photons in the sent signal. It also works in a lossy quantum channel, becoming a good bet for improving long-distance QKD.

Joint Preprocesser-Based Detectors for One-Way and Two-Way Cooperative Communication Networks

KAUST Repository

Abuzaid, Abdulrahman I.

2014-05-01

Efficient receiver designs for cooperative communication networks are becoming increasingly important. In previous work, cooperative networks communicated with the use of L relays. As the receiver is constrained, channel shortening and reduced-rank techniques were employed to design the preprocessing matrix that reduces the length of the received vector from L to U. In the first part of the work, a receiver structure is proposed which combines our proposed threshold selection criteria with the joint iterative optimization (JIO) algorithm that is based on the mean square error (MSE). Our receiver assists in determining the optimal U. Furthermore, this receiver provides the freedom to choose U for each frame depending on the tolerable difference allowed for MSE. Our study and simulation results show that by choosing an appropriate threshold, it is possible to gain in terms of complexity savings while having no or minimal effect on the BER performance of the system. Furthermore, the effect of channel estimation on the performance of the cooperative system is investigated. In the second part of the work, a joint preprocessor-based detector for cooperative communication networks is proposed for one-way and two-way relaying. This joint preprocessor-based detector operates on the principles of minimizing the symbol error rate (SER) instead of minimizing MSE. For a realistic assessment, pilot symbols are used to estimate the channel. From our simulations, it can be observed that our proposed detector achieves the same SER performance as that of the maximum likelihood (ML) detector with all participating relays. Additionally, our detector outperforms selection combining (SC), channel shortening (CS) scheme and reduced-rank techniques when using the same U. Finally, our proposed scheme has the lowest computational complexity.

No-go theorem for one-way quantum computing on naturally occurring two-level systems

International Nuclear Information System (INIS)

Chen Jianxin; Chen Xie; Duan Runyao; Ji Zhengfeng; Zeng Bei

2011-01-01

The ground states of some many-body quantum systems can serve as resource states for the one-way quantum computing model, achieving the full power of quantum computation. Such resource states are found, for example, in spin-(5/2) and spin-(3/2) systems. It is, of course, desirable to have a natural resource state in a spin-(1/2), that is, qubit system. Here, we give a negative answer to this question for frustration-free systems with two-body interactions. In fact, it is shown to be impossible for any genuinely entangled qubit state to be a nondegenerate ground state of any two-body frustration-free Hamiltonian. What is more, we also prove that every spin-(1/2) frustration-free Hamiltonian with two-body interaction always has a ground state that is a product of single- or two-qubit states. In other words, there cannot be any interesting entanglement features in the ground state of such a qubit Hamiltonian.

Extra virgin olive oil phenols and markers of oxidation in Greek smokers: a randomized cross-over study.

Science.gov (United States)

Moschandreas, J; Vissers, M N; Wiseman, S; van Putte, K P; Kafatos, A

2002-10-01

To examine the effect of a low phenol olive oil and high phenol olive oil on markers of oxidation and plasma susceptibility to oxidation in normolipaemic smokers. Randomized single-blind cross-over trial with two intervention periods. The Medical School and University Hospital of the University of Crete, Heraklion, Crete, Greece. Twenty-five healthy males and females completed the study. Each intervention was of three weeks duration and intervention periods were separated by a two week washout. Seventy grams of extra virgin olive oil was supplied to each subject per day in the intervention periods. The olive oils supplied differed in their phenol content by 18.6 mg/day. Two fasting venous blood samples were taken at the end of each intervention period. The markers of antioxidant capacity measured in fasting plasma samples (total plasma resistance to oxidation, concentrations of protein carbonyl as a marker of protein oxidation, malondialdehyde and lipid hydroperoxides as markers of lipid oxidation and the ferric reducing ability of plasma) did not differ significantly between the low and high phenol olive oil diets. No effect of olive oil phenols on markers of oxidation in smokers was detected. It may be that the natural concentrations of phenols in olive oil are too low to produce an effect in the post-absorptive phase. Possible reasons for period effects and interactions between diet and administration period need attention to aid further cross-over trials of this kind. Unilever Research Vlaardingen, The Netherlands.

Cross-Layer Design for Two-Way Relaying Networks with Multiple Antennas

Directory of Open Access Journals (Sweden)

zhuo wu

2015-10-01

Full Text Available In this paper, we developed a cross-layer design for two-way relaying (TWR networks with multiple antennas, where two single antenna source nodes exchange information with the aid of one multiple antenna relay node. The proposed cross-layer design considers adaptive modulation (AM and space-time block coding (STBC at the physical layer with an automatic repeat request (ARQ protocol at the data link layer, in order to maximize the spectral efficiency under specific delay and packet error ratio (PER constraints. An MMSE-interference cancellation (IC receiver is employed at the relay node, to remove the interference in the fist phase of the TWR transmission. The transmission mode is updated for each phase of the TWR transmission on a frame-by-frame basis, to match the time-varying channel conditions and exploit the system performance and throughput gain. Simulation results show that retransmission at the data link layer could alleviate rigorous error-control requirements at the physical layer, and thereby allows higher data transmission. As a result, cross-layer design helps to achieve considerable system spectral efficiency gain for TWR networks, compared to those without cross-layer design.

Dimensional crossover in fragmentation

Science.gov (United States)

Sotolongo-Costa, Oscar; Rodriguez, Arezky H.; Rodgers, G. J.

2000-11-01

Experiments in which thick clay plates and glass rods are fractured have revealed different behavior of fragment mass distribution function in the small and large fragment regions. In this paper we explain this behavior using non-extensive Tsallis statistics and show how the crossover between the two regions is caused by the change in the fragments’ dimensionality during the fracture process. We obtain a physical criterion for the position of this crossover and an expression for the change in the power-law exponent between the small and large fragment regions. These predictions are in good agreement with the experiments on thick clay plates.

Outage performance of opportunistic two-way amplify-and-forward relaying with outdated channel state information

KAUST Repository

Hwang, Kyusung; Ju, Minchul; Alouini, Mohamed-Slim

2013-01-01

In this paper, we study the outage performance of an amplify-and-forward (AF)-based two-way relaying (TWR) system with multiple relays where a single relay selection is performed based on outdated channel state information (CSI). Specifically, we

Energy efficient design for MIMO two-way AF multiple relay networks

KAUST Repository

Alsharoa, Ahmad M.

2014-04-01

This paper studies the energy efficient transmission and the power allocation problem for multiple two-way relay networks equipped with multi-input multi-output antennas where each relay employs an amplify-and-forward strategy. The goal is to minimize the total power consumption without degrading the quality of service of the terminals. In our analysis, we start by deriving closed-form expressions of the optimal powers allocated to terminals. We then employ a strong optimization tool based on the particle swarm optimization technique to find the optimal power allocated at each relay antenna. Our numerical results illustrate the performance of the proposed scheme and show that it achieves a sub-optimal solution very close to the optimal one.

Methodological adequacy of articles published in two open-access Brazilian cardiology periodicals.

Science.gov (United States)

Macedo, Cristiane Rufino; Silva, Davi Leite da; Puga, Maria Eduarda

2010-01-01

The use of rigorous scientific methods has contributed towards developing scientific articles of excellent methodological quality. This has made it possible to promote their citation and increase the impact factor. Brazilian periodicals have had to adapt to certain quality standards demanded by these indexing organizations, such as the content and the number of original articles published in each issue. This study aimed to evaluate the methodological adequacy of two Brazilian periodicals within the field of cardiology that are indexed in several databases and freely accessible through the Scientific Electronic Library Online (SciELO), and which are now indexed by the Web of Science (Institute for Scientific Information, ISI). Descriptive study at Brazilian Cochrane Center. All the published articles were evaluated according to merit assessment (content) and form assessment (performance). Ninety-six percent of the articles analyzed presented study designs that were adequate for answering the objectives. These two Brazilian periodicals within the field of cardiology published methodologically adequate articles, since they followed the quality standards. Thus, these periodicals can be considered both for consultation and as vehicles for publishing future articles. For further analyses, it is essential to apply other indicators of scientific activity such as bibliometrics, which evaluates quantitative aspects of the production, dissemination and use of information, and scientometrics, which is also concerned with the development of science policies, within which it is often superimposed on bibliometrics.

Biliary atresia: evaluation on two distinct periods at a reference pediatric service.

Science.gov (United States)

Queiroz, Thais Costa Nascentes; Ferreira, Alexandre Rodrigues; Fagundes, Eleonora Druve Tavares; Roquete, Mariza Leitão Valadares; Penna, Francisco José

2014-01-01

Biliary atresia is a progressive, idiopathic, fibro-obliterative disease of the extrahepatic biliary tree that presents with biliary obstruction exclusively in the neonatal period. To assess the differences regarding age at referral, age at surgery, duration of propaedeutics and waiting time for surgery between two groups of infants in different periods. Retrospective study of infants diagnosed with biliary atresia on two periods: 1983-1993 and 1998-2011. Biliary atresia was diagnosed in 129 infants, being 48 in casuistic I and 81 in casuistic II. The median age at admission was 94 and 60 days, respectively (P = 0.0001). On evaluating patients who had undergone portoenterostomy before 120 days of age, no difference was observed regarding the duration of propaedeutics or waiting time for surgery (P = 0.15), but difference was found when comparing the age at surgery (P = 0.002). Among those infants with no biliary flow and without liver transplantation or death after 18 post-operative months, the estimated probability of survival was 44.6% and 38.7% in casuistics I and II, respectively. In casuistic I, all infants who showed biliary flow were alive during the observation period and, in casuistic II, 80.3% were alive after 7 years of follow-up. Even though patients were admitted and treated earlier, it is clear that surgery could be done sooner. Delay in referral and timely propaedeutics were the main contributors.

The influence of an atmospheric Two-Way coupled model system on the predictability of extratropical cyclones

Science.gov (United States)

Schuster, Mareike; Thürkow, Markus; Weiher, Stefan; Kirchner, Ingo; Ulbrich, Uwe; Will, Andreas

2016-04-01

A general bias of global atmosphere ocean models, and also of the MPI-ESM, is an under-representation of the high latitude cyclone activity and an overestimation of the mid latitude cyclone activity in the North Atlantic, thus representing the extra-tropical storm track too zonal. We will show, that this effect can be antagonized by applying an atmospheric Two-Way Coupling (TWC). In this study we present a newly developed Two-Way Coupled model system, which is based on the MPI-ESM, and show that it is able to capture the mean storm track location more accurate. It also influences the sub-decadal deterministic predictability of extra-tropical cyclones and shows significantly enhanced skill compared to the "uncoupled" MPI-ESM standalone system. This study evaluates a set of hindcast experiments performed with said Two-Way Coupled model system. The regional model COSMO CLM is Two-Way Coupled to the atmosphere of the global Max-Plack-Institute Earth System Model (MPI-ESM) and therefore integrates and exchanges the state of the atmosphere every 10 minutes (MPI-TWC-ESM). In the coupled source region (North Atlantic), mesoscale processes which are relevant for the formation and early-stage development of cyclones are expected to be better represented, and therefore influence the large scale dynamics of the target region (Europe). The database covers 102 "uncoupled" years and 102 Two-Way Coupled years of the recent climate (1960-2010). Results are validated against the ERA-Interim reanalysis. Besides the climatological point of view, the design of this single model ensemble allows for an analysis of the predictability of the first and second leadyears of the hindcasts. As a first step to understand the improved predictability of cyclones, we will show a detailed analysis of climatologies for specific cyclone categories, sorted by season and region. Especially for cyclones affecting Europe, the TWC is capable to counteract the AOGCM's biases in the North Atlantic. Also

Algorithm for determining two-periodic steady-states in AC machines directly in time domain

Directory of Open Access Journals (Sweden)

Sobczyk Tadeusz J.

2016-09-01

Full Text Available This paper describes an algorithm for finding steady states in AC machines for the cases of their two-periodic nature. The algorithm enables to specify the steady-state solution identified directly in time domain despite of the fact that two-periodic waveforms are not repeated in any finite time interval. The basis for such an algorithm is a discrete differential operator that specifies the temporary values of the derivative of the two-periodic function in the selected set of points on the basis of the values of that function in the same set of points. It allows to develop algebraic equations defining the steady state solution reached in a chosen point set for the nonlinear differential equations describing the AC machines when electrical and mechanical equations should be solved together. That set of those values allows determining the steady state solution at any time instant up to infinity. The algorithm described in this paper is competitive with respect to the one known in literature an approach based on the harmonic balance method operated in frequency domain.

Distributed Role Selection With ANC and TDBC Protocols in Two-Way Relaying Systems

KAUST Repository

Ding, Haiyang

2015-09-28

This paper advocates a distributed role selection strategy to coordinate two-way relaying transmissions among three cooperative nodes. For such, the local channel state information comparison and decision feedback mechanism are merged into classical analog network coding (ANC) and time division broadcast (TDBC) protocols such that the cooperative role of each node can be designated in a distributed fashion. We refer to this distributed role selection rule as d-ROSE. In both ANC-based and TDBC-based two-way relaying scenarios, strict proof for the equivalence of d-ROSE and optimal ROSE is given, which indicates that albeit the different form, their final role decision is essentially the same. Outage analysis for the d-ROSE strategy is carried out and the scaling law of the system outage behavior at high signal-to-noise ratio (SNR) is characterized, which manifests that d-ROSE can enhance the system diversity gain to one-order higher relative to the ANC and TDBC protocols. It is also shown that d-ROSE can reduce the signaling overhead upto 60% to perform the outage-optimal role selection. Finally, the impacts of node placement on the outage performance as well as the average signaling overhead of d-ROSE are numerically evaluated and some useful conclusions are drawn. © 2015 IEEE.

Modelling of the PROTO-II crossover network

International Nuclear Information System (INIS)

Proulx, G.A.; Lackner, H.; Spence, P.; Wright, T.P.

1985-01-01

In order to drive a double ring, symmetrically fed bremsstrahlung diode, the PROTO II accelerator was redesigned. The radially converging triplate water line was reconfigured to drive two radial converging triplate lines in parallel. The four output lines were connected to the two input lines via an electrically enclosed tubular crossover network. Low-voltage Time Domain Reflectrometry (TDR) experiments were conducted on a full scale water immersed model of one section of the crossover network as an aid in this design. A lumped element analysis of the power flow through the network was inadequate in explaining the observed wave transmission and reflection characteristics. A more detailed analysis was performed with a circuit code in which we considered both localized lump-element and transmission line features of the crossover network. Experimental results of the model tests are given and compared with the circuit simulations. 7 figs

Teacher and Student Language Practices and Ideologies in a Third-Grade Two-Way Dual Language Program Implementation

Science.gov (United States)

Henderson, Kathryn I.; Palmer, Deborah K.

2015-01-01

This article provides an in-depth exploration of the language ecologies of two classrooms attempting to implement a two-way dual language (TWDL) program and its mediating conditions. Drawing on ethnographic methods and a sociocultural understanding of language, we examined both teachers' and students' language ideologies and language practices,…

Homogenization of non-uniformly bounded periodic diffusion energies in dimension two

International Nuclear Information System (INIS)

Braides, Andrea; Briane, Marc; Casado-Díaz, Juan

2009-01-01

This paper deals with the homogenization of two-dimensional oscillating convex functionals, the densities of which are equicoercive but not uniformly bounded from above. Using a uniform-convergence result for the minimizers, which holds for this type of scalar problems in dimension two, we prove in particular that the limit energy is local and recover the validity of the analogue of the well-known periodic homogenization formula in this degenerate case. However, in the present context the classical argument leading to integral representation based on the use of cut-off functions is useless due to the unboundedness of the densities. In its place we build sequences with bounded energy, which converge uniformly to piecewise-affine functions, taking point-wise extrema of recovery sequences for affine functions

Polaron crossover in molecular solids

International Nuclear Information System (INIS)

Zoli, Marco; Das, A N

2004-01-01

An analytical variational method is applied to the molecular Holstein Hamiltonian in which the dispersive features of the dimension dependent phonon spectrum are taken into account by a force constant approach. The crossover between a large and a small size polaron is monitored, in one, two and three dimensions and for different values of the adiabatic parameter, through the behaviour of the effective mass as a function of the electron-phonon coupling. By increasing the strength of the intermolecular forces the crossover becomes smoother and occurs at higher e-ph couplings. These effects are more evident in three dimensions. We show that our modified Lang-Firsov method starts to capture the occurrence of a polaron self-trapping transition when the electron energies become of order of the phonon energies. The self-trapping event persists in the fully adiabatic regime. At the crossover we estimate polaron effective masses of order ∼ 5-40 times the bare band mass according to the dimensionality and the value of the adiabatic parameter. Modified Lang-Firsov polaron masses are substantially reduced in two and three dimensions. There is no self-trapping in the antiadiabatic regime

Two-thumb technique is superior to two-finger technique during lone rescuer infant manikin CPR.

Science.gov (United States)

Udassi, Sharda; Udassi, Jai P; Lamb, Melissa A; Theriaque, Douglas W; Shuster, Jonathan J; Zaritsky, Arno L; Haque, Ikram U

2010-06-01

Infant CPR guidelines recommend two-finger chest compression with a lone rescuer and two-thumb with two rescuers. Two-thumb provides better chest compression but is perceived to be associated with increased ventilation hands-off time. We hypothesized that lone rescuer two-thumb CPR is associated with increased ventilation cycle time, decreased ventilation quality and fewer chest compressions compared to two-finger CPR in an infant manikin model. Crossover observational study randomizing 34 healthcare providers to perform 2 min CPR at a compression rate of 100 min(-1) using a 30:2 compression:ventilation ratio comparing two-thumb vs. two-finger techniques. A Laerdal Baby ALS Trainer manikin was modified to digitally record compression rate, compression depth and compression pressure and ventilation cycle time (two mouth-to-mouth breaths). Manikin chest rise with breaths was video recorded and later reviewed by two blinded CPR instructors for percent effective breaths. Data (mean+/-SD) were analyzed using a two-tailed paired t-test. Significance was defined qualitatively as pCPR, but there was no significant difference in percent effective breaths delivered between the two techniques. Two-thumb CPR had 4 fewer delivered compressions per minute, which may be offset by far more effective compression depth and compression pressure compared to two-finger technique. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

Two new ways of mapping sea ice thickness using ocean waves

Science.gov (United States)

Wadhams, P.

2010-12-01

TWO NEW METHODS OF MAPPING SEA ICE THICKNESS USING OCEAN WAVES. P. Wadhams (1,2), Martin Doble (1,2) and F. Parmiggiani (3) (1) Dept. of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, UK. (2) Laboratoire d’Océanographie de Villefranche, Université Pierre et Marie Curie, 06234 Villefranche-sur-Mer, France (2) ISAC-CNR, Bologna, Italy Two new methods of mapping ice thickness have been recently developed and tested, both making use of the dispersion relation of ocean waves in ice of radically different types. In frazil-pancake ice, a young ice type in which cakes less than 5 m across float in a suspension of individual ice crystals, the propagation of waves has been successfully modelled by treating the ice layer as a highly viscous fluid. The model predicts a shortening of wavelengths within the ice. Two-dimensional Fourier analysis of successive SAR subscenes to track the directional spectrum of a wave field as it enters an ice edge shows that waves do indeed shorten within the ice, and the change has been successfully used to predict the thickness of the frazil-pancake layer. Concurrent shipborne sampling in the Antarctic has shown that the method is accurate, and we now propose its use throughout the important frazil-pancake regimes in the world ocean (Antarctic circumpolar ice edge zone, Greenland Sea, Bering Sea and others). A radically different type of dispersion occurs when ocean waves enter the continuous icefields of the central Arctic, when they couple with the elastic ice cover to propagate as a flexural-gravity wave. A two-axis tiltmeter array has been used to measure the resulting change in the dispersion relation for long ocean swell (15-30 s) originating from storms in the Greenland Sea. The dispersion relation is slightly different from swell in the open ocean, so if two such arrays are placed a substantial distance (100s of km) apart and used to observe the changing wave period of arrivals from a given

Two New Long-period Hot Subdwarf Binaries with Dwarf Companions

Science.gov (United States)

Barlow, Brad N.; Liss, Sandra E.; Wade, Richard A.; Green, Elizabeth M.

2013-07-01

Hot subdwarf stars with F-K main sequence binary companions have been known for decades, but the first orbital periods for such systems were published just recently. Current observations suggest that most have long periods, on the order of years, and that some are or once were hierarchical triple systems. As part of a survey with the Hobby-Eberly Telescope, we have been monitoring the radial velocities of several composite-spectra binaries since 2005 in order to determine their periods, velocities, and eccentricities. Here we present observations and orbital solutions for two of these systems, PG 1449+653 and PG 1701+359. Similar to the other sdB+F/G/K binaries with solved orbits, their periods are long, 909 and 734 days, respectively, and pose a challenge to current binary population synthesis models of hot subdwarf stars. Intrigued by their relatively large systemic velocities, we also present a kinematical analysis of both targets and find that neither is likely a member of the Galactic thin disk. Based on observations obtained with the Hobby-Eberly Telescope, which is a joint project of the University of Texas at Austin, the Pennsylvania State University, Stanford University, Ludwig-Maximilians-Universität München, and Georg-August-Universität Göttingen.

Extinction maps toward the Milky Way bulge: Two-dimensional and three-dimensional tests with apogee

Energy Technology Data Exchange (ETDEWEB)

Schultheis, M. [Université de Nice Sophia-Antipolis, CNRS, Observatoire de Côte d' Azur, Laboratoire Lagrange, 06304 Nice Cedex 4 (France); Zasowski, G. [Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD 21218 (United States); Allende Prieto, C. [Instituto de Astrofísica de Canarias, Calle Vía Láctea s/n, E-38205 La Laguna, Tenerife (Spain); Anders, F.; Chiappini, C. [Leibniz-Institut für Astrophysik Potsdam (AIP), D-14482 Potsdam (Germany); Beaton, R. L.; García Pérez, A. E.; Majewski, S. R. [Department of Astronomy, University of Virginia, Charlottesville, VA 22904 (United States); Beers, T. C. [National Optical Astronomy Observatory, Tucson, AZ 85719 (United States); Bizyaev, D. [Apache Point Observatory, Sunspot, NM 88349 (United States); Frinchaboy, P. M. [Department of Physics and Astronomy, Texas Christian University, TCU Box 298840, Fort Worth, TX 76129 (United States); Ge, J. [Astronomy Department, University of Florida, Gainesville, FL 32611 (United States); Hearty, F.; Schneider, D. P. [Department of Astronomy and Astrophysics, The Pennsylvania State University, University Park, PA 16802 (United States); Holtzman, J. [New Mexico State University, Las Cruces, NM 88003 (United States); Muna, D. [Department of Astronomy, The Ohio State University, Columbus, OH 43210 (United States); Nidever, D. [Department of Astronomy, University of Michigan, Ann Arbor, MI 48109 (United States); Shetrone, M., E-mail: mathias.schultheis@oca.eu, E-mail: gail.zasowski@gmail.com [McDonald Observatory, The University of Texas at Austin, Austin, TX 78712 (United States)

2014-07-01

Galactic interstellar extinction maps are powerful and necessary tools for Milky Way structure and stellar population analyses, particularly toward the heavily reddened bulge and in the midplane. However, due to the difficulty of obtaining reliable extinction measures and distances for a large number of stars that are independent of these maps, tests of their accuracy and systematics have been limited. Our goal is to assess a variety of photometric stellar extinction estimates, including both two-dimensional and three-dimensional extinction maps, using independent extinction measures based on a large spectroscopic sample of stars toward the Milky Way bulge. We employ stellar atmospheric parameters derived from high-resolution H-band Apache Point Observatory Galactic Evolution Experiment (APOGEE) spectra, combined with theoretical stellar isochrones, to calculate line-of-sight extinction and distances for a sample of more than 2400 giants toward the Milky Way bulge. We compare these extinction values to those predicted by individual near-IR and near+mid-IR stellar colors, two-dimensional bulge extinction maps, and three-dimensional extinction maps. The long baseline, near+mid-IR stellar colors are, on average, the most accurate predictors of the APOGEE extinction estimates, and the two-dimensional and three-dimensional extinction maps derived from different stellar populations along different sightlines show varying degrees of reliability. We present the results of all of the comparisons and discuss reasons for the observed discrepancies. We also demonstrate how the particular stellar atmospheric models adopted can have a strong impact on this type of analysis, and discuss related caveats.

Extinction maps toward the Milky Way bulge: Two-dimensional and three-dimensional tests with apogee

International Nuclear Information System (INIS)

Schultheis, M.; Zasowski, G.; Allende Prieto, C.; Anders, F.; Chiappini, C.; Beaton, R. L.; García Pérez, A. E.; Majewski, S. R.; Beers, T. C.; Bizyaev, D.; Frinchaboy, P. M.; Ge, J.; Hearty, F.; Schneider, D. P.; Holtzman, J.; Muna, D.; Nidever, D.; Shetrone, M.

2014-01-01

Galactic interstellar extinction maps are powerful and necessary tools for Milky Way structure and stellar population analyses, particularly toward the heavily reddened bulge and in the midplane. However, due to the difficulty of obtaining reliable extinction measures and distances for a large number of stars that are independent of these maps, tests of their accuracy and systematics have been limited. Our goal is to assess a variety of photometric stellar extinction estimates, including both two-dimensional and three-dimensional extinction maps, using independent extinction measures based on a large spectroscopic sample of stars toward the Milky Way bulge. We employ stellar atmospheric parameters derived from high-resolution H-band Apache Point Observatory Galactic Evolution Experiment (APOGEE) spectra, combined with theoretical stellar isochrones, to calculate line-of-sight extinction and distances for a sample of more than 2400 giants toward the Milky Way bulge. We compare these extinction values to those predicted by individual near-IR and near+mid-IR stellar colors, two-dimensional bulge extinction maps, and three-dimensional extinction maps. The long baseline, near+mid-IR stellar colors are, on average, the most accurate predictors of the APOGEE extinction estimates, and the two-dimensional and three-dimensional extinction maps derived from different stellar populations along different sightlines show varying degrees of reliability. We present the results of all of the comparisons and discuss reasons for the observed discrepancies. We also demonstrate how the particular stellar atmospheric models adopted can have a strong impact on this type of analysis, and discuss related caveats.

Circadian phase and period responses to light stimuli in two nocturnal rodents

NARCIS (Netherlands)

Sharma, Vijay Kumar; Daan, Serge

2002-01-01

We report period response curves (tauRC) for two nocturnal Murid species from India, Mus booduga and Mus platythrix. We further discuss the method of phase shift estimation in the presence of tau-changes, because such changes pose a serious methodological problem in the estimation of phase shifts.

Standardizing information exchange towards the end user. Present data models with two way communication over the Internet

International Nuclear Information System (INIS)

Saele, Hanne; Graabak, Ingeborg; Tangen, Grethe

2000-01-01

The two-way communication towards the end consumer is in little use so far. There are probably several reasons for this but one important reason may be the lack of standardized interfaces for the information exchange towards the end user. The lack of such standards results in substantial system investment risks for the network companies because the systems may not be developed further and maintained should the deliverer leave the market. The communication channel Internet has expanded quickly and in Norway of today (1999) 25 to 30 % of the households have an Internet connection. The use of existing infrastructure and already tried out technology for information transferrals may contribute to making two-way communication more reasonable and functional. In the report various alternatives of standardized information exchange towards the end users are evaluated. Various formats are discussed with the following demands in mind: 1) Shall be suited for all types of communication media. 2) An international standard followed by everyone. 3) Reliable information transferral and flexible. The focus is on what kind of information is being transferred and how this is organized, and not on how the information is transferred. The discussed alternatives are evaluated both regarding traditional solutions for two- way communication and the use of the Internet. The following format alternatives are discussed: EDIEL/EDIFACT, ODEL(GS2), LonWorks/Echelon, UCA, DLMS/COSEM, COBRA and DCOM. The formats represent communication at various levels but they are mentioned in the report because they are often mentioned as possible standard formats towards the end user: ODEL, DLSM/COSEM and UCA. EDIEL is not suited for this interface. The market for two-way communication systems is international and it does not seem to be practical to establish a joint Norwegian/Swedish standard. The work with establishing one standard should therefore be continued through international standardization

Sleep and health in oil rig workers--before and after a two week work period offshore.

Science.gov (United States)

Waage, Siri; Pallesen, Ståle; Moen, Bente Elisabeth; Bjorvatn, Bjørn

2013-01-01

This study compared subjective sleep and subjective health complaints among Norwegian oil rig workers, before and after a two week work period. The study also compared differences between two different work schedules. The workers worked either two weeks of day shift (n=90) or two weeks of a swing shift schedule (n=93), involving one week of night shifts, immediately followed by one week of day shifts. Overall, the workers reported significantly poorer sleep quality and more complaints of insomnia at the end compared to the start of the work period. However, there was no significant difference in terms of subjective health complaints. Furthermore, there were no clear differences in changes in sleep quality, insomnia or subjective health complaints during the work period between day- and swing shift workers. However, at the end of the work period a higher proportion of insomniacs were seen among swing shift workers compared with day workers. To conclude, sleep quality and complaints of insomnia became worse during the work period. However, there were few differences in changes in terms of sleep or subjective health complaints between day- and swing shift, suggesting that 12 h day shift affected sleep and health similarly to the schedule involving night work.

Comparative bioavailability of two formulations of sibutramine.

Science.gov (United States)

Franco Spínola, A C; Almeida, S; Filipe, A; Neves, R; Abolfathi, Z; Yritia, M; Anctil, D

2009-10-01

This study was conducted in order to compare the bioavailability of two capsule formulations containing 15 mg of sibutramine, N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine hydrochloride monohydrate, 84485-00-7 CAS registry number. 62 healthy subjects were enrolled in a single-center, randomized, single-dose, open-label, 2-way crossover study, with a minimum washout period of 14 days. Plasma samples were collected up to 72.0 hours post-dosing. R-sibutramine, S-sibutramine, N-mono-desmethyl-sibutramine (M1) and N-di-desmethyl-sibutramine (M2) levels were determined by reverse liquid chromatography and detected by tandem mass spectrometry detection, LC/MS/MS method. Pharmacokinetic parameters used for bioequivalence assessment were the area under the concentration-time curve from time zero to time of last non-zero concentration (AUC0-t) and the maximum observed concentration (Cmax). These parameters were determined from sibutramine enantiomers as well from M1 and M2 concentration data using non-compartmental analysis. The 90% confidence intervals obtained by analysis of variance were 89.25 - 122.88% for Cmax, 90.37 - 123.18% for AUC0-t and 91.20 - 122.38% for AUCinf for R-sibutramine and 88.27 - 124.08% for Cmax, 86.15 - 121.78% for AUC0-t and 88.02 - 120.96% for AUCinf for S-sibutramine. These results were all within the range of 80.00 - 125.00% established by regulatory requirements. Bioequivalence between formulations was concluded both in terms of rate and extent of absorption.

BILIARY ATRESIA: evaluation on two distinct periods at a reference pediatric service

Directory of Open Access Journals (Sweden)

Thais Costa Nascentes QUEIROZ

2014-03-01

Full Text Available Context Biliary atresia is a progressive, idiopathic, fibro-obliterative disease of the extrahepatic biliary tree that pre­sents with biliary obstruction exclusively in the neonatal period. Objectives To assess the differences regarding age at referral, age at surgery, duration of propaedeutics and waiting time for surgery between two groups of infants in different periods. Methods Retrospective study of infants diagnosed with biliary atresia on two periods: 1983-1993 and 1998-2011. Results Biliary atresia was diagnosed in 129 infants, being 48 in casuistic I and 81 in casuistic II. The median age at admission was 94 and 60 days, respectively (P = 0.0001. On evaluating patients who had undergone portoenterostomy before 120 days of age, no difference was observed regarding the duration of propaedeutics or waiting time for surgery (P = 0.15, but difference was found when comparing the age at surgery (P = 0.002. Among those infants with no biliary flow and without liver transplantation or death after 18 post-operative months, the estimated probability of survival was 44.6% and 38.7% in casuistics I and II, respectively. In casuistic I, all infants who showed biliary flow were alive during the observation period and, in casuistic II, 80.3% were alive after 7 years of follow-up. Conclusions Even though patients were admitted and treated earlier, it is clear that surgery could be done sooner. Delay in referral and timely propaedeutics were the main contributors.

Pharmacokinetic interaction of telmisartan with s-amlodipine: an open-label, two-period crossover study in healthy Korean male volunteers.

Science.gov (United States)

Noh, Yook-Hwan; Lim, Hyeong-Seok; Kim, Mi Jo; Kim, Yo Han; Choi, Hee Youn; Sung, Hye Ryoung; Jin, Seok-Joon; Lim, Jonglae; Bae, Kyun-Seop

2012-07-01

Telmisartan belongs to a class of orally active angiotensin II receptor blockers (ARBs), and S-amlodipine is an enantiomer of amlodipine. Amlodipine is a racemic mixture and the calcium channel blocking (CCB) effect is confined to S-amlodipine, whereas R-amlodipine has a 1000-fold lower activity and no racemization occurs in vivo in human plasma. Combination therapy of ARBs with CCBs provides advantages for blood pressure control and vascular protection over monotherapy. To investigate the effects of coadministration of telmisartan and S-amlodipine on the steady-state pharmacokinetic properties of each drug as a drug-drug interaction study required before developing the fixed-dose combination agent. This study comprised 2 separate parts, A and B; each was a multiple-dose, open-label, 2-sequence, 2-period, crossover study in healthy male Korean volunteers. In part A, volunteers were administered 80 mg of telmisartan, either alone or with 5 mg of S-amlodipine. In part B, volunteers were administered 5 mg of S-amlodipine, either alone or with 80 mg of telmisartan. Blood samples were taken on days 9 and 37, following the final dose of each treatment, and at 0 (predose), 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 10, 12, and 24 hours after administration in part A, and were taken at 0 (predose), 1, 2, 3, 4, 5, 6, 7, 8, 10, 12, 14, and 24 hours after administration in part B. Plasma concentrations were determined using LC-MS/MS. The pharmacokinetic properties of each drug after coadministration of telmisartan and S-amlodipine were compared with those of each drug administered alone. Tolerability was assessed using measurements of vital signs, clinical chemistry tests, and interviews. Fifty-six volunteers were enrolled (32 in part A and 24 in part B), and all completed except 4 volunteers (3 withdrawn in part A and 1 withdrawn in part B). The geometric mean ratios (GMRs) (90% CI) for the C(max,ss) and AUC(τ,ss) of telmisartan (with or without S-amlodipine) were 1.039 (0

The regional dimension of sectoral innovativeness: An empirical investigation of two specialized suppliers and two science-based industries

DEFF Research Database (Denmark)

Buerger, M.; Cantner, U.

2011-01-01

The aim of this paper is to test the way in which geographical proximity and technological relatedness relate to an industry's innovative output. Two mechanisms are therefore tested, namely, urbanization economies and the regional exploitation of technological relatedness. A new dataset is applied......, which includes German patent applications from within the period 1995 to 2006. Four industries are considered, two of which are science-based, whereas the remaining two are specialized supplier industries. While diversity is associated with high innovative output in the specialized supplier industries......, the same does not hold for science-based industries. However, both kinds of industries seem to benefit from recombinant innovation....

Thermomechanical cycling and two-way memory effect induced in Cu-Zn-Al

International Nuclear Information System (INIS)

Pons, J.

1999-01-01

The two-way shape memory effect (TWME) has been induced by thermomechanical cycling in Cu-Zn-Al alloys using a dedicated hydraulic mechanical testing soft machine with complete computer control of force, elongation and temperature. The results concerning single crystals (composition Cu-16.9 wt.% Zn-7.7 wt.% Al, nominal M s of 273 K) and polycrystals (Cu-15.8 wt.% Zn-8.3 wt.% Al, nominal M s of 230 K, mean grain size of 1 mm) are reported for two training protocols (sequence of one thermomechanical cycle of education followed by one stress free thermal cycle to check the TWME or twenty consecutive thermomechanical cycles followed by one or two checking thermal cycles). The capacity of the trained specimen for producing work under an antagonist compressive stress is also studied and the behaviour of the deformation of the specimen under such a condition at different temperatures is analysed in terms of a competition between the contributions of the different variants: trained variants with an intrinsic deformation in the direction of the tensile stress of the training process, trained variants with an intrinsic deformation which is not well orientated with respect to this direction (in the polycrystal) and new variants with an intrinsic deformation in the direction of the compressive stress which can replace the educated variants. (orig.)

Effect of relevant umklapp process on the two-leg Hubbard ladder with a half-filled band under pressure

International Nuclear Information System (INIS)

Haddad, S.; Bennaceur, R.

1999-01-01

By means of perturbative renormalization approach we study the effect of relevant umklapp process on dimensional crossover caused by interladder one particle hopping t bot in weakly coupled two-leg Hubbard ladders with a half filled-band. We found that a crossover takes place at a finite value t botc which increases as the amplitude of umklapp process increases. For t bot botc the system undergoes a phase transition to the spin density wave phase (SDW) via the two particle hopping process, while for t bot >t botc the system undergoes a crossover to the two dimensional Fermi liquid phase via one particle hopping process. (orig.)

Near-optimal power allocation with PSO algorithm for MIMO cognitive networks using multiple AF two-way relays

KAUST Repository

Alsharoa, Ahmad M.

2014-06-01

In this paper, the problem of power allocation for a multiple-input multiple-output two-way system is investigated in underlay Cognitive Radio (CR) set-up. In the CR underlay mode, secondary users are allowed to exploit the spectrum allocated to primary users in an opportunistic manner by respecting a tolerated temperature limit. The secondary networks employ an amplify-and-forward two-way relaying technique in order to maximize the sum rate under power budget and interference constraints. In this context, we formulate an optimization problem that is solved in two steps. First, we derive a closed-form expression of the optimal power allocated to terminals. Then, we employ a strong optimization tool based on particle swarm optimization algorithm to find the power allocated to secondary relays. Simulation results demonstrate the efficiency of the proposed solution and analyze the impact of some system parameters on the achieved performance. © 2014 IEEE.

Independent attacks in imperfect settings: A case for a two-way quantum key distribution scheme

International Nuclear Information System (INIS)

Shaari, J.S.; Bahari, Iskandar

2010-01-01

We review the study on a two-way quantum key distribution protocol given imperfect settings through a simple analysis of a toy model and show that it can outperform a BB84 setup. We provide the sufficient condition for this as a ratio of optimal intensities for the protocols.

Experimental investigation of cross-over jets in a rib-roughened trailing-edge cooling channel

Science.gov (United States)

Xue, Fei

Increasing the rotor inlet temperature can dramatically increase the efficiency and power output of the gas turbine engine. However, the melting point of turbine blade material limits the realistic upper bound of the rotor inlet temperature. As a result, the development of high temperature turbine blade material and advanced turbine blade cooling technology determines the future of turbine blade engine. Adding impingement jet holes and rib turbulators in the inner cooling channel of the gas turbine blades are two effective ways to enhance the cooling effects. The purpose of this study is to figure out the influence of different combinations of jet holes and rib turbulators on the heat transfer efficiency. A tabletop scale test model is used in the study to simulate the cooling cavity of trailing edge and its feed channel in a real gas turbine blade. The Dimensional Analysis Theory is used in the study to eliminate the influence of scaling. Two different crossover slots are tested with 5 different rib arrangements, and each of the test geometries is tested for 6 jet Reynolds numbers ranging from 10,000 to 36,000. The two different crossover slots are the crossover slots with 0 and 5 degree tilt angles. The four different rib arrangements are ribs with 0 degree, 45 degree, 90 degree and 135 degree angles of attack with respect to the flow direction. Furthermore, a smooth test section (no ribs) was also tested. The steady state liquid crystal thermography is used to quantify the heat transfer performance of the target areas. The variation of Nusselt number versus Reynolds number is plotted for each of the 10 geometries. Also, the variation of Nusselt number versus Reynolds number are compared for different rib angles of attack with the same crossover slot tilt angle, and between different crossover slots tilt angles with the same rib angle. The results show that, the area-weighted average Nusselt number increases monotonically with the Reynolds number; the target

Hybrid Genetic Algorithm with Multiparents Crossover for Job Shop Scheduling Problems

Directory of Open Access Journals (Sweden)

Noor Hasnah Moin

2015-01-01

Full Text Available The job shop scheduling problem (JSSP is one of the well-known hard combinatorial scheduling problems. This paper proposes a hybrid genetic algorithm with multiparents crossover for JSSP. The multiparents crossover operator known as extended precedence preservative crossover (EPPX is able to recombine more than two parents to generate a single new offspring distinguished from common crossover operators that recombine only two parents. This algorithm also embeds a schedule generation procedure to generate full-active schedule that satisfies precedence constraints in order to reduce the search space. Once a schedule is obtained, a neighborhood search is applied to exploit the search space for better solutions and to enhance the GA. This hybrid genetic algorithm is simulated on a set of benchmarks from the literatures and the results are compared with other approaches to ensure the sustainability of this algorithm in solving JSSP. The results suggest that the implementation of multiparents crossover produces competitive results.

Head-on crashes on two-way interurban roads: a public health concern in road safety.

Science.gov (United States)

Olabarria, Marta; Santamariña-Rubio, Elena; Marí-Dell'Olmo, Marc; Gotsens, Mercè; Novoa, Ana M; Borrell, Carme; Pérez, Katherine

2015-09-01

To describe the magnitude and characteristics of crashes and drivers involved in head-on crashes on two-way interurban roads in Spain between 2007 and 2012, and to identify the factors associated with the likelihood of head-on crashes on these roads compared with other types of crash. A cross-sectional study was conducted using the National Crash Register. The dependent variables were head-on crashes with injury (yes/no) and drivers involved in head-on crashes (yes/no). Factors associated with head-on crashes and with being a driver involved in a head-on crash versus other types of crash were studied using a multivariate robust Poisson regression model to estimate proportion ratios (PR) and confidence intervals (95% CI). There were 9,192 head-on crashes on two-way Spanish interurban roads. A total of 15,412 men and 3,862 women drivers were involved. Compared with other types of crash, head-on collisions were more likely on roads 7 m or more wide, on road sections with curves, narrowings or drop changes, on wet or snowy surfaces, and in twilight conditions. Transgressions committed by drivers involved in head-on crashes were driving in the opposite direction and incorrectly overtaking another vehicle. Factors associated with a lower probability of head-on crashes were the existence of medians (PR=0.57; 95%CI: 0.48-0.68) and a paved shoulder of less than 1.5 meters (PR=0.81; 95%CI: 0.77-0.86) or from 1.5 to 2.45 meters (PR=0.90; 95%CI: 0.84-0.96). This study allowed the characterization of crashes and drivers involved in head-on crashes on two-way interurban roads. The lower probability observed on roads with median strips point to these measures as an effective way to reduce these collisions. Copyright © 2014 SESPAS. Published by Elsevier Espana. All rights reserved.

Channel Estimation and Optimal Training Design for Correlated MIMO Two-Way Relay Systems in Colored Environment

OpenAIRE

Wang, Rui; Tao, Meixia; Mehrpouyan, Hani; Hua, Yingbo

2014-01-01

In this paper, while considering the impact of antenna correlation and the interference from neighboring users, we analyze channel estimation and training sequence design for multi-input multi-output (MIMO) two-way relay (TWR) systems. To this end, we propose to decompose the bidirectional transmission links into two phases, i.e., the multiple access (MAC) phase and the broadcasting (BC) phase. By considering the Kronecker-structured channel model, we derive the optimal linear minimum mean-sq...

Effect of indentation temperature on nickel-titanium indentation-induced two-way shape-memory surfaces

International Nuclear Information System (INIS)

Brinckmann, Stephan A.; Frensemeier, Mareike; Laursen, Christopher M.; Maier, Hans J.; Britz, Dominik; Schneider, Andreas S.; Mücklich, Frank; Frick, Carl P.

2016-01-01

This study investigated the effect of temperature on indentation-induced one-way and two-way shape memory properties in Ti-50.3 at% Ni alloy. Indentation temperatures ranged from below the martensite finish temperature (M f ) to above the austenite finish temperature (A f ) with the explicit intent of varying the indented phase. Samples used in the study were characterized by differential scanning calorimetry and transmission electron microscopy (TEM). The topographical behavior of the shape memory effect was investigated through Vickers indentation and laser scanning 3D confocal measurements. The magnitudes of deformation recovery associated with the one-way and two-way shape-memory effect (OWSME, TWSME) decreased with increasing indentation temperatures, which is a reflection of the decreasing volume of material experiencing martensitic reorientation during indentation. Indented and subsequently planarized samples exhibited TWSME protrusions when thermally cycled. Laser scanning measurements were used to characterize the height of the protrusions as increasing depths of material were polished away, which provided insight into the overall affected volume beneath the indent. As indentation temperatures increased, both the height of the protrusions, and consequently the polish depth necessary to completely remove the effect, decreased. TEM investigations revealed that directly underneath a nanoindent the microstructure was very fine due to the high-strain deformation; this was contrasted with a much coarser grain size in the undeformed bulk material. Overall these results strongly imply that the deformation recovery associated with the OWSME and TWSME can be maximized by indenting at temperatures at M f or below because the volume of deformed microstructure beneath the indent is maximized. This finding has important practical value for any potential application that utilizes indentation-induced phase transformation deformation recovery in NiTi.

Effect of indentation temperature on nickel-titanium indentation-induced two-way shape-memory surfaces

Energy Technology Data Exchange (ETDEWEB)

Brinckmann, Stephan A. [University of Wyoming, Mechanical Engineering Department, Laramie (United States); Frensemeier, Mareike [INM - Leibniz Institute for New Materials, Saarbrücken (Germany); Laursen, Christopher M. [University of Wyoming, Mechanical Engineering Department, Laramie (United States); Maier, Hans J. [Leibniz Universität Hannover, Institut für Werkstoffkunde (Materials Science), Garbsen (Germany); Britz, Dominik [Saarland University, Department of Materials Science and Engineering, Saarbrücken (Germany); Schneider, Andreas S. [AG der Dillinger Hüttenwerke, Department for Research, Development and Plate-Design, Dillingen (Germany); Mücklich, Frank [Saarland University, Department of Materials Science and Engineering, Saarbrücken (Germany); Frick, Carl P., E-mail: cfrick@uwyo.edu [University of Wyoming, Mechanical Engineering Department, Laramie (United States)

2016-10-15

This study investigated the effect of temperature on indentation-induced one-way and two-way shape memory properties in Ti-50.3 at% Ni alloy. Indentation temperatures ranged from below the martensite finish temperature (M{sub f}) to above the austenite finish temperature (A{sub f}) with the explicit intent of varying the indented phase. Samples used in the study were characterized by differential scanning calorimetry and transmission electron microscopy (TEM). The topographical behavior of the shape memory effect was investigated through Vickers indentation and laser scanning 3D confocal measurements. The magnitudes of deformation recovery associated with the one-way and two-way shape-memory effect (OWSME, TWSME) decreased with increasing indentation temperatures, which is a reflection of the decreasing volume of material experiencing martensitic reorientation during indentation. Indented and subsequently planarized samples exhibited TWSME protrusions when thermally cycled. Laser scanning measurements were used to characterize the height of the protrusions as increasing depths of material were polished away, which provided insight into the overall affected volume beneath the indent. As indentation temperatures increased, both the height of the protrusions, and consequently the polish depth necessary to completely remove the effect, decreased. TEM investigations revealed that directly underneath a nanoindent the microstructure was very fine due to the high-strain deformation; this was contrasted with a much coarser grain size in the undeformed bulk material. Overall these results strongly imply that the deformation recovery associated with the OWSME and TWSME can be maximized by indenting at temperatures at M{sub f} or below because the volume of deformed microstructure beneath the indent is maximized. This finding has important practical value for any potential application that utilizes indentation-induced phase transformation deformation recovery in NiTi.

Eigenfunctions of the continuous spectrum of a two-dimensional periodic optical waveguide

International Nuclear Information System (INIS)

Derguzov, V.I.

1986-01-01

One proves the existence of the eigenfunctions of the continuous spectrum of a two-dimensional periodic optical waveguide. One gives a normalization of the eigenfunctions of the continuous spectrum relative to an indefinite inner product. One defines the concept of the genus of the multipliers of a Hamiltonian equation, corresponding to the continuous spectrum of the optical waveguide

On achievable rate of two-way relaying cognitive radio with space alignment

KAUST Repository

Sboui, Lokman

2015-09-11

We study a multiple-antenna two-way relaying (TWR) spectrum sharing system. A space alignment (SA) technique is adopted by the secondary users (SU\\'s) to avoid interference with the primary users (PU\\'s). We derive the optimal power allocation that maximizes the TWR achievable sum-rate of the SU while respecting the total power budget and the relay power constraints. In the numerical results, we quantify the sum-rate gain of using the SA in the TWR CR and we show that the SU sum-rate is very limited when the relay power is low or the PU\\'s power and its resulting interference is high. © 2015 IEEE.

Relativistic BCS-BEC Crossover at Quark Level

Directory of Open Access Journals (Sweden)

Zhuang P.

2010-10-01

Full Text Available The non-relativistic G0G formalism of BCS-BEC crossover at finite temperature is extended to relativistic fermion systems. The theory recovers the BCS mean field approximation at zero temperature and the non-relativistic results in a proper limit. For massive fermions, when the coupling strength increases, there exist two crossovers from the weak coupling BCS superfluid to the non-relativistic BEC state and then to the relativistic BEC state. For color superconductivity at moderate baryon density, the matter is in the BCS-BEC crossover region, and the behavior of the pseudogap is quite similar to that found in high temperature superconductors.

CRCM + BATS-R-US two-way coupling

Science.gov (United States)

Glocer, A.; Fok, M.; Meng, X.; Toth, G.; Buzulukova, N.; Chen, S.; Lin, K.

2013-04-01

We present the coupling methodology and validation of a fully coupled inner and global magnetosphere code using the infrastructure provided by the Space Weather Modeling Framework (SWMF). In this model, the Comprehensive Ring Current Model (CRCM) represents the inner magnetosphere, while the Block-Adaptive-Tree Solar-Wind Roe-Type Upwind Scheme (BATS-R-US) represents the global magnetosphere. The combined model is a global magnetospheric code with a realistic ring current and consistent electric and magnetic fields. The computational performance of the model was improved to surpass real-time execution by the use of the Message Passing Interface (MPI) to parallelize the CRCM. Initial simulations under steady driving found that the coupled model resulted in a higher pressure in the inner magnetosphere and an inflated closed field-line region as compared to simulations without inner-magnetosphere coupling. Our validation effort was split into two studies. The first study examined the ability of the model to reproduce Dst for a range of events from the Geospace Environment Modeling (GEM) Dst Challenge. It also investigated the possibility of a baseline shift and compared two approaches to calculating Dst from the model. We found that the model did a reasonable job predicting Dst and Sym-H according to our two metrics of prediction efficiency and predicted yield. The second study focused on the specific case of the 22 July 2009 moderate geomagnetic storm. In this study, we directly compare model predictions and observations for Dst, THEMIS energy spectragrams, TWINS ENA images, and GOES 11 and 12 magnetometer data. The model did an adequate job reproducing trends in the data. Moreover, we found that composition can have a large effect on the result.

The German East-West Mortality Difference: Two Crossovers Driven by Smoking.

Science.gov (United States)

Vogt, Tobias; van Raalte, Alyson; Grigoriev, Pavel; Myrskylä, Mikko

2017-06-01

Before the fall of the Berlin Wall, mortality was considerably higher in the former East Germany than in West Germany. The gap narrowed rapidly after German reunification. The convergence was particularly strong for women, to the point that Eastern women aged 50-69 now have lower mortality despite lower incomes and worse overall living conditions. Prior research has shown that lower smoking rates among East German female cohorts born in the 1940s and 1950s were a major contributor to this crossover. However, after 1990, smoking behavior changed dramatically, with higher smoking intensity observed among women in the eastern part of Germany. We forecast the impact of this changing smoking behavior on East-West mortality differences and find that the higher smoking rates among younger East German cohorts will reverse their contemporary mortality advantage. Mortality forecasting methods that do not account for smoking would, perhaps misleadingly, forecast a growing mortality advantage for East German women. Experience from other countries shows that smoking can be effectively reduced by strict anti-smoking policies. Instead, East Germany is becoming an example warning of the consequences of weakening anti-smoking policies and changing behavioral norms.

Two-Way Tables: Issues at the Heart of Statistics and Probability for Students and Teachers

Science.gov (United States)

Watson, Jane; Callingham, Rosemary

2014-01-01

Some problems exist at the intersection of statistics and probability, creating a dilemma in relation to the best approach to assist student understanding. Such is the case with problems presented in two-way tables representing conditional information. The difficulty can be confounded if the context within which the problem is set is one where…

A Latent Class Multidimensional Scaling Model for Two-Way One-Mode Continuous Rating Dissimilarity Data

Science.gov (United States)

Vera, J. Fernando; Macias, Rodrigo; Heiser, Willem J.

2009-01-01

In this paper, we propose a cluster-MDS model for two-way one-mode continuous rating dissimilarity data. The model aims at partitioning the objects into classes and simultaneously representing the cluster centers in a low-dimensional space. Under the normal distribution assumption, a latent class model is developed in terms of the set of…

Two-way cooperative AF relaying in spectrum-sharing systems: Enhancing cell-edge performance

KAUST Repository

Xia, Minghua

2012-09-01

In this contribution, two-way cooperative amplify-and-forward (AF) relaying technique is integrated into spectrumsharing wireless systems to improve spectral efficiency of secondary users (SUs). In order to share the available spectrum resources originally dedicated to primary users (PUs), the transmit power of a SU is optimized with respect to the average tolerable interference power at primary receivers. By analyzing outage probability and achievable data rate at the base station and at a cell-edge SU, our results reveal that the uplink performance is dominated by the average tolerable interference power at primary receivers, while the downlink always behaves like conventional one-way AF relaying and its performance is dominated by the average signal-to-noise ratio (SNR). These important findings provide fresh perspectives for system designers to improve spectral efficiency of secondary users in next-generation broadband spectrum-sharing wireless systems. © 2012 IEEE.

Popov approximation for composite bosons in the BCS-BEC crossover

International Nuclear Information System (INIS)

Pieri, P.; Strinati, G.C.

2005-01-01

Theoretical treatments of the BCS-BEC crossover need to provide as accurate as possible descriptions of the two regimes where the diluteness condition applies, either in terms of the constituent fermions (BCS limit) or of the composite bosons which form as bound-fermion pairs (BEC limit). This has to occur via a single fermionic theory that bridges across these two limiting representations. In this paper, we set up successive improvements of the fermionic theory, that result into composite bosons described at the level of either the Bogoliubov or the Popov approximations for pointlike bosons. This work bears on the recent experimental advances on the BCS-BEC crossover with trapped Fermi atoms, which show the need for accurate theoretical descriptions of the BEC side of the crossover

Wireless Energy Harvesting Two-Way Relay Networks with Hardware Impairments.

Science.gov (United States)

Peng, Chunling; Li, Fangwei; Liu, Huaping

2017-11-13

This paper considers a wireless energy harvesting two-way relay (TWR) network where the relay has energy-harvesting abilities and the effects of practical hardware impairments are taken into consideration. In particular, power splitting (PS) receiver is adopted at relay to harvests the power it needs for relaying the information between the source nodes from the signals transmitted by the source nodes, and hardware impairments is assumed suffered by each node. We analyze the effect of hardware impairments [-20]on both decode-and-forward (DF) relaying and amplify-and-forward (AF) relaying networks. By utilizing the obtained new expressions of signal-to-noise-plus-distortion ratios, the exact analytical expressions of the achievable sum rate and ergodic capacities for both DF and AF relaying protocols are derived. Additionally, the optimal power splitting (OPS) ratio that maximizes the instantaneous achievable sum rate is formulated and solved for both protocols. The performances of DF and AF protocols are evaluated via numerical results, which also show the effects of various network parameters on the system performance and on the OPS ratio design.

Two-Way Multiuser Mixed RF/FSO Relaying: Performance Analysis and Power Allocation

KAUST Repository

Al-Eryani, Yasser F.

2018-03-21

In this paper, the performance of two-way multiuser mixed radio frequency/free space optical (RF/FSO) relay networks with opportunistic user scheduling and asymmetric channel fading is studied. RF links are used to conduct data transmission between users and relay node, while a FSO link is used to conduct data transmission on the last-mile communication link between the relay node and base station. The RF links are assumed to follow a Rayleigh fading model, while the FSO links are assumed to follow a unified Gamma-Gamma atmospheric turbulence fading model with pointing error. First, closed-form expressions for the exact outage probability, asymptotic (high signal-to-noise ratio) outage probability, average symbol error rate, and average ergodic channel capacity are derived assuming a heterodyne detection scheme. The asymptotic results are used to conduct a power optimization algorithm where expressions for optimal transmission power values for the transmitting nodes are provided. Additionally, performance comparisons between the considered two-way-relaying (TWR) network and the oneway- relaying (OWR) network are provided and discussed. Also, the impact of several system parameters, including number of users, pointing errors, atmospheric turbulence conditions, and outage probability threshold on the overall network performance are investigated. All the theoretical results are validated by Monte Carlo simulations. The results show that the TWR scheme almost doubles the network ergodic capacity compared to that of the OWR scheme with the same outage performance. Additionally, it is shown that under weak-to-moderate weather turbulence conditions and small pointing error, the outage probability is dominated by the RF downlink with a neglected effect for the user selection process at the RF uplink transmission. However, for severe pointing error, the outage probability is dominated by the FSO uplink/downlink transmission.

Complexity analyses show two distinct types of nonlinear dynamics in short heart period variability recordings

Science.gov (United States)

Porta, Alberto; Bari, Vlasta; Marchi, Andrea; De Maria, Beatrice; Cysarz, Dirk; Van Leeuwen, Peter; Takahashi, Anielle C. M.; Catai, Aparecida M.; Gnecchi-Ruscone, Tomaso

2015-01-01

Two diverse complexity metrics quantifying time irreversibility and local prediction, in connection with a surrogate data approach, were utilized to detect nonlinear dynamics in short heart period (HP) variability series recorded in fetuses, as a function of the gestational period, and in healthy humans, as a function of the magnitude of the orthostatic challenge. The metrics indicated the presence of two distinct types of nonlinear HP dynamics characterized by diverse ranges of time scales. These findings stress the need to render more specific the analysis of nonlinear components of HP dynamics by accounting for different temporal scales. PMID:25806002

Mechanical Design of Downhole Tractor Based on Two-Way Self-locking Mechanism

Science.gov (United States)

Fang, Delei; Shang, Jianzhong; Luo, Zirong; Wu, Guoheng; Liu, Yiying

2018-03-01

Based on the technology of horizontal well tractor, a kind of downhole tractor was developed which can realize Two-Way self-locking function. Aiming at the needs of horizontal well logging to realize the target of small size, high traction and high reliability, the tractor selects unique heart-shaped CAM as the locking mechanism. The motion principle of telescopic downhole tractor, the design of mechanical structure and locking principle of the locking mechanism are all analyzed. The mathematical expressions of traction are obtained by mechanical analysis of parallel support rod in the locking mechanism. The force analysis and contour design of the heart-shaped CAM are performed, which can lay the foundation for the development of tractor prototype.

Collaboration or negotiation: two ways of interacting suggest how shared thinking develops.

Science.gov (United States)

Mejía-Arauz, Rebeca; Rogoff, Barbara; Dayton, Andrew; Henne-Ochoa, Richard

2018-03-09

This paper contrasts two ways that shared thinking can be conceptualized: as negotiation, where individuals join their separate ideas, or collaboration, as people mutually engage together in a unified process, as an ensemble. We argue that these paradigms are culturally based, with the negotiation model fitting within an assumption system of separate entities-an assumption system we believe to be common in psychology and in middle-class European American society-and the collaboration model fitting within a holistic worldview that appears to be common in Indigenous-heritage communities of the Americas. We discuss cultural differences in children's interactions-as negotiation or collaboration-that suggest how these distinct paradigms develop. Copyright © 2018 Elsevier Ltd. All rights reserved.

Performance analysis of two-way amplify and forward relaying with adaptive modulation

KAUST Repository

Hwang, Kyusung

2009-09-01

In this paper, we study two-way amplify-and-forward relaying in conjunction with adaptive modulation over a multiple relay network. In order to keep the diversity order equal to the number of relays and maintain a low complexity, we consider the best relay selection scheme in this work. Based on the proposed selection criterion for the best relay, we analyze the average spectral efficiency by its approximated upper bound. In addition, we extend the proposed scheme to the case where a direct path between source and destination exists. Our numerical examples show that the proposed system offers a considerable gain in the spectral efficiency while satisfying the error rates requirements. ©2009 IEEE.

Chaotic advection and heat transfer in two similar 2-D periodic flows and in their corresponding 3-D periodic flows

Science.gov (United States)

Vinsard, G.; Dufour, S.; Saatdjian, E.; Mota, J. P. B.

2016-03-01

Chaotic advection can effectively enhance the heat transfer rate between a boundary and fluids with high Prandtl number. These fluids are usually highly viscous and thus turbulent agitation is not a viable solution since the energy required to mix the fluid would be prohibitive. Here, we analyze previously obtained results on chaotic advection and heat transfer in two similar 2-D periodic flows and on their corresponding 3-D periodic flows when an axial velocity component is superposed. The two flows studied are the flow between eccentric rotating cylinders and the flow between confocal ellipses. For both of these flows the analysis is simplified because the Stokes equations can be solved analytically to obtain a closed form solution. For both 2-D periodic flows, we show that chaotic heat transfer is enhanced by the displacement of the saddle point location during one period. Furthermore, the enhancement by chaotic advection in the elliptical geometry is approximately double that obtained in the cylindrical geometry because there are two saddle points instead of one. We also explain why, for high eccentricity ratios, there is no heat transfer enhancement in the cylindrical geometry. When an axial velocity component is added to both of these flows so that they become 3-D, previous work has shown that there is an optimum modulation frequency for which chaotic advection and heat transfer enhancement is a maximum. Here we show that the optimum modulation frequency can be derived from results without an axial flow. We also explain by physical arguments other previously unanswered questions in the published data.

Are two spaces better than one? The effect of spacing following periods and commas during reading.

Science.gov (United States)

Johnson, Rebecca L; Bui, Becky; Schmitt, Lindsay L

2018-04-24

The most recent edition of the American Psychological Association (APA) Manual states that two spaces should follow the punctuation at the end of a sentence. This is in contrast to the one-space requirement from previous editions. However, to date, there has been no empirical support for either convention. In the current study, participants performed (1) a typing task to assess spacing usage and (2) an eye-tracking experiment to assess the effect that punctuation spacing has on reading performance. Although comprehension was not affected by punctuation spacing, the eye movement record suggested that initial processing of the text was facilitated when periods were followed by two spaces, supporting the change made to the APA Manual. Individuals' typing usage also influenced these effects such that those who use two spaces following a period showed the greatest overall facilitation from reading with two spaces.

Using a Montessori method to increase eating ability for institutionalised residents with dementia: a crossover design.

Science.gov (United States)

Lin, Li-Chan; Huang, Ya-Ju; Watson, Roger; Wu, Shiao-Chi; Lee, Yue-Chune

2011-11-01

To investigate the efficacy of applying a Montessori intervention to improve the eating ability and nutritional status of residents with dementia in long-term care facilities. An early intervention for eating difficulties in patients with dementia can give them a better chance of maintaining independence and reduce the risk of malnutrition. An experimental crossover design was employed. Twenty-nine residents were chosen from two dementia special care units in metropolitan Taipei. To avoid contamination between participants in units using both Montessori and control interventions, two dementia special care units were randomly assigned into Montessori intervention (I1) and routine activities (I2) sequence groups. A two-period crossover design was used, with 15 residents assigned to Montessori intervention sequence I (I1, I2) and 14 residents assigned to Montessori intervention sequence II (I2, I1). On each intervention day, residents were given their assigned intervention. Montessori intervention was provided in 30-min sessions once every day, three days per week, for eight weeks. There was a two-week washout period between each intervention. There was a significant reduction in the Edinburgh Feeding Evaluation in Dementia score for the Montessori intervention period but not for the routine activities period, while the mean differences for the Eating Behavior Scale score, self-feeding frequency and self-feeding time were significantly higher than those of the routine activities period. Except for the Mini-Nutritional Assessment score post-test being significantly less than the pre-test for the routine activities period, no significant differences for any other variables were found for the routine activities period. This study confirms the efficacy of a Montessori intervention protocol on eating ability of residents with dementia. Adopting Montessori intervention protocols to maintain residents' self-feeding ability in clinical practice is recommended. Montessori

Crossover driven by time-reversal symmetry breaking in quantum chaos

International Nuclear Information System (INIS)

Taniguchi, N.; Hashimoto, A.; Simons, B.D.; Altshuler, B.L.

1994-01-01

Parametric correlations of the energy spectra of quantum chaotic systems are presented in the presence of time-reversal symmetry-breaking perturbations. The spectra disperse as a function of two external perturbations, one of which preserves time-reversal symmetry, while the other violates it. Exact analytical expressions for the parametric two-point autocorrelation function of the density of states are derived in the crossover region by means of the supermatrix method. For the orthogonal-unitary crossover, the velocity distribution is determined and shown to deviate from Gaussian. (orig.)

Study of active crossover network | Tyona | Nigerian Journal of Physics

African Journals Online (AJOL)

An active crossover network system has been realized using an active component LF356 with a JFET input. The net work has two drives, the low frequency drive (Bass) and the high frequency drive (Treble). It employs high level crossover technique. The circuit performance was adequately verified and the frequency ...

Study of Λ parameters and crossover phenomena in SU(N) x SU(N) sigma models in two dimensions

International Nuclear Information System (INIS)

Shigemitsu, J.; Kogut, J.B.

1981-01-01

The spin system analogues of recent studies of the string tension and Λ parameters of SU(N) gauge theories in 4 dimensions are carried out for the SU(N) x SU(N) and O(N) models in 2 dimensions. The relations between the Λ parameters of both the Euclidean and Hamiltonian formulation of the lattice models and the Λ parameter of the continuum models are obtained. The one loop finite renormalization of the speed of light in the lattice Hamiltonian formulations of the O(N) and SU(N) x SU(N) models is calculated. Strong coupling calculations of the mass gaps of these spin models are done for all N and the constants of proportionality between the gap and the Λ parameter of the continuum models are obtained. These results are contrasted with similar calculations for the SU(N) gauge models in 3+1 dimensions. Identifying suitable coupling constants for discussing the N → infinity limits, the numerical results suggest that the crossover from weak to strong coupling in the lattice O(N) models becomes less abrupt as N increases while the crossover for the SU(N) x SU(N) models becomes more abrupt. The crossover in SU(N) gauge theories also becomes more abrupt with increasing N, however, at an even greater rate than in the SU(N) x SU(N) spin models

Phase fluctuations in two coaxial quasi-one-dimensional superconducting cylindrical surfaces serving as a model system for superconducting nanowire bundles

Energy Technology Data Exchange (ETDEWEB)

Wong, C.H., E-mail: ch.kh.vong@urfu.ru [Institute of Physics and Technology, Ural Federal University, Clear Water Bay, Kowloon (Russian Federation); Wu, R.P.H., E-mail: pak-hong-raymond.wu@connect.polyu.hk [Department of Applied Physics, The Hong Kong Polytechnic University (Hong Kong); Lortz, R., E-mail: lortz@ust.hk [Department of Physics, Hong Kong University of Science and Technology (Hong Kong)

2017-03-15

The dimensional crossover from a 1D fluctuating state at high temperatures to a 3D phase coherent state in the low temperature regime in two coaxial weakly-coupled cylindrical surfaces formed by two-dimensional arrays of parallel nanowires is studied via an 8-state 3D-XY model. This system serves as a model for quasi-one-dimensional superconductors in the form of bundles of weakly-coupled superconducting nanowires. A periodic variation of the dimensional crossover temperature T{sub DC} is observed when the inner superconducting cylindrical surface is rotated in the angular plane. T{sub DC} reaches a maximum when the relative angle between the cylinders is 2.81°, which corresponds to the maximum separation of nanowires between the two cylindrical surfaces. We demonstrate that the relative strength of phase fluctuations in this system is controllable by the rotational angle between the two surfaces with a strong suppression of the fluctuation strength at 2.81°. The phase fluctuations are suppressed gradually upon cooling, before they abruptly vanish below T{sub DC}. Our model thus allows us to study how phase fluctuations can be suppressed in quasi-one-dimensional superconductors in order to achieve a global phase coherent state throughout the nanowire array with zero electric resistance.

Pinning synchronization of two general complex networks with periodically intermittent control

Directory of Open Access Journals (Sweden)

Meng Fanyu

2015-12-01

Full Text Available In this paper, the method of periodically pinning intermittent control is introduced to solve the problem of outer synchronization between two complex networks. Based on the Lyapunov stability theory, differential inequality method and adaptive technique, some simple synchronous criteria have been derived analytically. At last, both the theoretical and numerical analysis illustrate the effectiveness of the proposed control methodology. This method not only reduces the conservatism of control gain but also saves the cost of production.These advantages make this method having a large application scope in the real production process.

Simulation of Two-Way Pushdown Automata Revisited

Directory of Open Access Journals (Sweden)

Robert Glück

2013-09-01

Full Text Available The linear-time simulation of 2-way deterministic pushdown automata (2DPDA by the Cook and Jones constructions is revisited. Following the semantics-based approach by Jones, an interpreter is given which, when extended with random-access memory, performs a linear-time simulation of 2DPDA. The recursive interpreter works without the dump list of the original constructions, which makes Cook's insight into linear-time simulation of exponential-time automata more intuitive and the complexity argument clearer. The simulation is then extended to 2-way nondeterministic pushdown automata (2NPDA to provide for a cubic-time recognition of context-free languages. The time required to run the final construction depends on the degree of nondeterminism. The key mechanism that enables the polynomial-time simulations is the sharing of computations by memoization.

Explicit finite-difference solution of two-dimensional solute transport with periodic flow in homogenous porous media

Directory of Open Access Journals (Sweden)

Djordjevich Alexandar

2017-12-01

Full Text Available The two-dimensional advection-diffusion equation with variable coefficients is solved by the explicit finitedifference method for the transport of solutes through a homogenous two-dimensional domain that is finite and porous. Retardation by adsorption, periodic seepage velocity, and a dispersion coefficient proportional to this velocity are permitted. The transport is from a pulse-type point source (that ceases after a period of activity. Included are the firstorder decay and zero-order production parameters proportional to the seepage velocity, and periodic boundary conditions at the origin and at the end of the domain. Results agree well with analytical solutions that were reported in the literature for special cases. It is shown that the solute concentration profile is influenced strongly by periodic velocity fluctuations. Solutions for a variety of combinations of unsteadiness of the coefficients in the advection-diffusion equation are obtainable as particular cases of the one demonstrated here. This further attests to the effectiveness of the explicit finite difference method for solving two-dimensional advection-diffusion equation with variable coefficients in finite media, which is especially important when arbitrary initial and boundary conditions are required.

Periodic Sturm-Liouville problems related to two Riccati equations of constant coefficients

International Nuclear Information System (INIS)

Khmelnytskaya, K.V.; Rosu, H.C.; Gonzalez, A.

2010-01-01

We consider two closely related Riccati equations of constant parameters whose particular solutions are used to construct the corresponding class of supersymmetrically coupled second-order differential equations. We solve analytically these parametric periodic problems along the whole real axis. Next, the analytically solved model is used as a case study for a powerful numerical approach that is employed here for the first time in the investigation of the energy band structure of periodic not necessarily regular potentials. The approach is based on the well-known self-matching procedure of James (1949) and implements the spectral parameter power series solutions introduced by Kravchenko (2008). We obtain additionally an efficient series representation of the Hill discriminant based on Kravchenko's series.

Application of estimating effective dose from external radiation using two dosimeters during maintenance periods at KNPPS

International Nuclear Information System (INIS)

Kim, Hee Geun; Kong, Tae Young

2008-01-01

The application of a two-dosimeter and its algorithm and a test of its use in an inhomogeneous high radiation field are described. The goal was to develop an improved method for estimating the effective dose during maintenance periods at Korean nuclear power plants (NPPs). The use of the method in domestic and international NPPs including USA, Canada and Japan was also investigated. The algorithms used by the Canadian Ontario Power Generation (OPG) and American ANSI HPS N13.41, Lakshmanan, NCRP, EPRI and Texas A and M University were extensively analyzed as two-dosimeter algorithms. The possibility of their application to NPPs was evaluated using data for each algorithm from two-dosimeter results for an inhomogeneous high radiation field during maintenance periods at Korean NPPs. (author)

Joint Bandwidth and Power Allocation for MIMO Two-Way Relays-Assisted Overlay Cognitive Radio Systems

KAUST Repository

Alsharoa, Ahmad; Ghazzai, Hakim; Yaacoub, Elias; Alouini, Mohamed-Slim; Kamal, Ahmed

2015-01-01

This paper studies the achievable cognitive sum rate of an overlay cognitive radio (CR) system assisted with multiple antennas two-way relays in which primary users (PUs) cooperate with cognitive users (CUs) for mutual benefits. In this context, the problem of both bandwidth and power allocation is investigated. We propose that the CUs are allowed to allocate a part of the PUs spectrum to perform their cognitive transmission. In return, acting as amplify-and-forward two-way relays, they are exploited to support PUs to reach their target data rates over the remaining bandwidth. Power expressions for optimal transmit power allocated per PU and CU antenna are derived under primary quality-of-service constraint in addition to bandwidth and power budget constraints. More specifically, CUs act as relays for the PUs transmission and gain some spectrum as long as they respect these constraints. After deriving the optimal transmit powers, we employ a strong optimization tool based on swarm intelligence to optimize the full and complex relay amplification gain matrices in addition to the bandwidths released to primary and cognitive transmission. Furthermore, three different utility functions are considered in our optimization problems depending on the level of fairness among CUs.

Joint Bandwidth and Power Allocation for MIMO Two-Way Relays-Assisted Overlay Cognitive Radio Systems

KAUST Repository

Alsharoa, Ahmad

2015-10-08

This paper studies the achievable cognitive sum rate of an overlay cognitive radio (CR) system assisted with multiple antennas two-way relays in which primary users (PUs) cooperate with cognitive users (CUs) for mutual benefits. In this context, the problem of both bandwidth and power allocation is investigated. We propose that the CUs are allowed to allocate a part of the PUs spectrum to perform their cognitive transmission. In return, acting as amplify-and-forward two-way relays, they are exploited to support PUs to reach their target data rates over the remaining bandwidth. Power expressions for optimal transmit power allocated per PU and CU antenna are derived under primary quality-of-service constraint in addition to bandwidth and power budget constraints. More specifically, CUs act as relays for the PUs transmission and gain some spectrum as long as they respect these constraints. After deriving the optimal transmit powers, we employ a strong optimization tool based on swarm intelligence to optimize the full and complex relay amplification gain matrices in addition to the bandwidths released to primary and cognitive transmission. Furthermore, three different utility functions are considered in our optimization problems depending on the level of fairness among CUs.

On the thermal degradation of the two way memory effect in Cu-Al-Be alloys

International Nuclear Information System (INIS)

Flores-Zuniga, H.; Rios-Jara, D.

1994-01-01

The mechanisms associated to such a degradation of the Two Way Shape Memory Effect (TWSME) are still being discussed. In Cu-Al-Ni alloys two different steps, with different rates of degradation of the TWSME, were observed on aging at temperatures between 200 and 220 C. The first step was associated with the annihilation of the dislocations created during the training process. The second step was attributed to an oriented bainitic type precipitation. In Cu-Zn-Al alloys, the observed degradation of the TWSME with aging at temperatures between 100 and 140 C, was also associated with two mechanisms: first to the annihilation of dislocations and next to the precipitation of an α phase. In the present work, the same type of study was performed for Cu-Al-Be alloys. However, in-situ transmission electron microscopy (TEM) observations of the effect of temperature were included, which revealed the actual mechanisms driving the TWSME degradation process

Towards Understanding the Two Way Interaction Effects of Extraversion and Openness to Experience on Career Commitment

Science.gov (United States)

Arora, Ridhi; Rangnekar, Santosh

2016-01-01

In this study, we examined potential two-way interaction effects of the Big Five personality traits extraversion and openness to experience on career commitment measured in terms of three components of career identity, career resilience, and career planning. Participants included 450 managers from public and private sector organizations in North…

Optimal transmit power allocation for MIMO two-way cognitive relay networks with multiple relays using AF strategy

KAUST Repository

Alsharoa, Ahmad M.; Ghazzai, Hakim; Alouini, Mohamed-Slim

2014-01-01

In this letter, we consider a multiple-input multiple-output two-way cognitive radio system under a spectrum sharing scenario, where primary and secondary users operate on the same frequency band. The secondary terminals aims to exchange different

Examining Interior Grid Nudging Techniques Using Two-Way Nesting in the WRF Model for Regional Climate Modeling

Science.gov (United States)

This study evaluates interior nudging techniques using the Weather Research and Forecasting (WRF) model for regional climate modeling over the conterminous United States (CONUS) using a two-way nested configuration. NCEP–Department of Energy Atmospheric Model Intercomparison Pro...

Topical Nasal Anesthesia in Flexible Bronchoscopy--A Cross-Over Comparison between Two Devices.

Directory of Open Access Journals (Sweden)

Thomas Fuehner

Full Text Available Topical airway anesthesia is known to improve tolerance and patient satisfaction during flexible bronchoscopy (FB. Lidocaine is commonly used, delivered as an atomized spray. The current study assesses safety and patient satisfaction for nasal anesthesia of a new atomization device during outpatient bronchoscopy in lung transplant recipients.Using a prospective, non-blinded, cross-over design, patients enrolled between 01-10-2014 and 24-11-2014 received 2% lidocaine using the standard reusable nasal atomizer (CRNA. Those enrolled between 25-11-2014 and 30-01-2015, received a disposable intranasal mucosal atomization device (DIMAD. After each procedure, the treating physician, their assistant and the patient independently rated side-effects and satisfaction, basing their responses on visual analogue scales (VAS. At their next scheduled bronchoscopy during the study period, patients then received the alternative atomizer. Written consent was obtained prior to the first bronchoscopy, and the study approved by the institutional ethics committee.Of the 252 patients enrolled between 01-10-2014 and 30-01-2015, 80 (32% received both atomizers. Physicians reported better efficacy (p = 0.001 and fewer side effects (p< = 0.001 for DIMAD in patients exposed to both procedures. Among patients with one visit, physicians and their assistants reported improved efficacy (p = 0.018, p = 0.002 and fewer side effects (p< = 0.001, p = 0.029 for the disposable atomizer, whereas patients reported no difference in efficacy or side effects (p = 0.72 and p = 0.20. No severe adverse events were noted. The cost of the reusable device was 4.08€ per procedure, compared to 3.70€ for the disposable device.Topical nasal anesthesia via a disposable intranasal mucosal atomization device (DIMAD offers comparable safety and patient comfort, compared to conventional reusable nasal atomizers (CRNA in lung transplant recipients. Procedural costs were reduced by 0.34€ per

Understanding the cluster randomised crossover design: a graphical illustraton of the components of variation and a sample size tutorial.

Science.gov (United States)

Arnup, Sarah J; McKenzie, Joanne E; Hemming, Karla; Pilcher, David; Forbes, Andrew B

2017-08-15

In a cluster randomised crossover (CRXO) design, a sequence of interventions is assigned to a group, or 'cluster' of individuals. Each cluster receives each intervention in a separate period of time, forming 'cluster-periods'. Sample size calculations for CRXO trials need to account for both the cluster randomisation and crossover aspects of the design. Formulae are available for the two-period, two-intervention, cross-sectional CRXO design, however implementation of these formulae is known to be suboptimal. The aims of this tutorial are to illustrate the intuition behind the design; and provide guidance on performing sample size calculations. Graphical illustrations are used to describe the effect of the cluster randomisation and crossover aspects of the design on the correlation between individual responses in a CRXO trial. Sample size calculations for binary and continuous outcomes are illustrated using parameters estimated from the Australia and New Zealand Intensive Care Society - Adult Patient Database (ANZICS-APD) for patient mortality and length(s) of stay (LOS). The similarity between individual responses in a CRXO trial can be understood in terms of three components of variation: variation in cluster mean response; variation in the cluster-period mean response; and variation between individual responses within a cluster-period; or equivalently in terms of the correlation between individual responses in the same cluster-period (within-cluster within-period correlation, WPC), and between individual responses in the same cluster, but in different periods (within-cluster between-period correlation, BPC). The BPC lies between zero and the WPC. When the WPC and BPC are equal the precision gained by crossover aspect of the CRXO design equals the precision lost by cluster randomisation. When the BPC is zero there is no advantage in a CRXO over a parallel-group cluster randomised trial. Sample size calculations illustrate that small changes in the specification of

Two-way laser ranging and time transfer experiments between LOLA and an Earth-based satellite laser ranging station

Science.gov (United States)

Mao, D.; Sun, X.; Neumann, G. A.; Barker, M. K.; Mazarico, E. M.; Hoffman, E.; Zagwodzki, T. W.; Torrence, M. H.; Mcgarry, J.; Smith, D. E.; Zuber, M. T.

2017-12-01

Satellite Laser Ranging (SLR) has established time-of-flight measurements with mm precision to targets orbiting the Earth and the Moon using single-ended round-trip laser ranging to passive optical retro-reflectors. These high-precision measurements enable advances in fundamental physics, solar system dynamics. However, the received signal strength suffers from a 1/R4 decay, which makes it impractical for measuring distances beyond the Moon's orbit. On the other hand, for a two-way laser transponder pair, where laser pulses are both transmitted to and received from each end of the laser links, the signal strength at both terminals only decreases by 1/R2, thus allowing a greater range of distances to be covered. The asynchronous transponder concept has been previously demonstrated by a test in 2005 between the Mercury Laser Altimeter (MLA) aboard the MESSENGER (MErcury Surface, Space ENvironment, Geochemistry, and Ranging) spacecraft and NASA's Goddard Geophysical and Astronomical Observatory (GGAO) at a distance of ˜0.16 AU. In October 2013, regular two-way transponder-type range measurements were obtained over 15 days between the Lunar Laser Communication Demonstration (LLCD) aboard the Lunar Atmosphere and Dust Environment Explorer (LADEE) spacecraft and NASA's ground station at White Sands, NM. The Lunar Orbiter Laser Altimeter (LOLA) aboard the Lunar Reconnaissance Orbiter (LRO) provides us a unique capability to test time-transfer beyond near Earth orbit. Here we present results from two-way transponder-type experiments between LOLA and GGAO conducted in March 2014 and 2017. As in the time-transfer by laser link (T2L2) experiments between a ground station and an earth-orbiting satellite, LOLA and GGAO ranged to each other simultaneously in these two-way tests at lunar distance. We measured the time-of-flight while cross-referencing the spacecraft clock to the ground station time. On May 4th, 2017, about 20 minutes of two-way measurements were collected. The

Escitalopram in painful polyneuropathy: A randomized, placebo-controlled, cross-over trial

DEFF Research Database (Denmark)

Otto, Marit; Bach, Flemming W; Jensen, Troels S

2008-01-01

Serotonin (5-HT) is involved in pain modulation via descending pathways in the central nervous system. The aim of this study was to test if escitalopram, a selective serotonin reuptake inhibitor (SSRI), would relieve pain in polyneuropathy. The study design was a randomized, double-blind, placebo......-controlled cross-over trial. The daily dose of escitalopram was 20mg once daily. During the two treatment periods of 5 weeks duration, patients rated pain relief (primary outcome variable) on a 6-point ordered nominal scale. Secondary outcome measures comprised total pain and different pain symptoms (touch...

Magnetic anisotropy of two-dimensional nanostructures: Transition-metal triangular stripes

International Nuclear Information System (INIS)

Dorantes-Davila, J.; Villasenor-Gonzalez, P.; Pastor, G.M.

2005-01-01

The magnetic anisotropy energy (MAE) of one-dimensional stripes having infinite length and triangular lateral structure are investigated in the framework of a self-consistent tight-binding method. One observes discontinuous changes in the easy magnetization direction along the crossover from one to two dimensions. The MAE oscillates as a function of stripe width and depends strongly on the considered transition metal (TM). The MAE of the two-leg ladder is strongly reduced as compared to that of the monoatomic chain and the convergence to the two-dimensional limit is rather slow

Two-way quantum communication: Generalization of secure ...

Indian Academy of Sciences (India)

states among the n nodes of a quantum network, with the aid of a special kind of ... replica of the information state, i.e., this process has one-way quantum ... with respect to increase in the number of qubits going towards the controller Charlie.

A two-way nesting procedure for an ocean model with application to the Norwegian Sea

Energy Technology Data Exchange (ETDEWEB)

Heggelund, Yngve; Berntsen, Jarle

2000-11-01

Two-way nesting for a {sigma}-coordinate ocean model is implemented. The test case is a traveling low pressure along the west coast of Norway. Different methods for interaction between the coarse grid and the fine grid have been investigated. It is found that both a Dirichlet type and a FRS-type boundary condition for the fine grid give reasonable results for this test case. The FRS-type boundary condition gives a smoother transition between the coarse and fine grid, but more noise in the interior of the fine grid. With no feedback from the fine grid to the coarse grid, phase differences between the solutions on the two grids cause unphysical vortices to be found at the interface between the grids. (author)

Anomalous short period geomagnetic variations at two stations in Sri Lanka

International Nuclear Information System (INIS)

Kunaratnam, K.

1986-08-01

An analysis of the rates of change in the geomagnetic field components in the period range 20-600 sec recorded at Kondavil and Hikkaduwa, two stations in the equatorial electrojet belt near the northern and south western coasts respectively of Sri Lanka, shows anomalous variations. The results confirm induced current concentration in the Palk Strait and deflection of induced currents around the southerncoast of Sri Lanka postulated by earlier workers from observations of SSC and Bay events at Indian stations and from analogue and numerical model studies. At Kondavil, which is situated close to the geomagnetic equator, no appreciable difference in the night-time and day-time values of ΔZ/ΔH and ΔD/ΔH ratios was noticed while at Hikkaduwa, a station situated under the edge of the equatorial electrojet belt, a day-time enhancement of ΔZ/ΔH ratios was found at all periods in the observed range. An enhancement of the H component at Colombo over that at Hikkaduwa was also found at short periods, the enhancement being greater at day-time. The day-time enhancement in the ΔZ/ΔH ratios at Hikkaduwa and in the ratio of the H components at Colombo and Hikkaduwa could be due to the effect of the equatorial electrojet on the short period variations. (author)

Analysis of multi-step transitions in spin crossover nanochains

Energy Technology Data Exchange (ETDEWEB)

Chiruta, Daniel [GEMaC, Université de Versailles Saint-Quentin-en-Yvelines, CNRS-UVSQ (UMR 8635), 78035 Versailles Cedex (France); LISV, Université de Versailles Saint-Quentin-en-Yvelines, 78140 Velizy (France); Faculty of Electrical Engineering and Computer Science, Stefan cel Mare University, Suceava 720229 (Romania); Linares, Jorge, E-mail: jorge.linares@uvsq.fr [GEMaC, Université de Versailles Saint-Quentin-en-Yvelines, CNRS-UVSQ (UMR 8635), 78035 Versailles Cedex (France); Garcia, Yann, E-mail: yann.garcia@uclouvain.be [Institute of Condensed Matter and Nanosciences, Université Catholique de Louvain, Molecules, Solids and Reactivity (IMCN/MOST), Place Louis Pasteur, 1, 1348 Louvain-la-Neuve (Belgium); Dimian, Mihai [Faculty of Electrical Engineering and Computer Science, Stefan cel Mare University, Suceava 720229 (Romania); Dahoo, Pierre Richard [LATMOS, Université de Versailles-Saint-Quentin-en-Yvelines, CNRS-UPMC-UVSQ (UMR 8190), 78280 Guyancourt (France)

2014-02-01

The temperature driven phase transition occurring in spin crossover nanochains has been studied by an Ising-like model considering both short-range and long-range interactions. Various types of spin crossover profiles have been described in this framework, including a novel three-step transition identified in a nanosystem with eight molecules, which is modeled for the first time. A special interest has been also given to stepwise transitions accompanied by two hysteresis loops. The edge and size effects on spin crossover behavior have been investigated in order to get a deeper insight of the underlying mechanisms involved in these unusual spin transitions.

“Beyond Morality.” Discourse on Homosexuality in Croatian Newspapers from the Sociosemiotic Perspective: Comparison of Two Periods

Directory of Open Access Journals (Sweden)

Sandra Antulov

2011-06-01

Full Text Available This paper aims to analyse and compare two newspaper articles dealing with issues of gay people in Croatia that were published in two different periods. The first article dates from the early 1990s, which was the starting point of contemporary Croatian gay activism. The second was published 16 years later, in 2008, within a different social and political context. It was the period when gay activism in Croatia had already reached some of its aims, and when the discourse on homosexuality had become more visible and acceptable in the media. In comparing these two periods, we focus on surface differences between two newspaper articles, while at the deep level we look for similarities and unchanged features. Our perspective is sociosemiotic – it will be explained in more detail in the next section. For now, it needs to be stressed that we integrate both verbal and visual elements of the two articles, explore differences and similarities in the discursive strategies of constructing and representing homosexuality, and analyse differences and similarities in aspects of utterances and utterance actors involved.

A Prospective Randomized, Double-Blind, Two-Period Crossover Pharmacokinetic Trial Comparing Green Coffee Bean Extract-A Botanically Sourced Caffeine-With a Synthetic USP Control.

Science.gov (United States)

Morton, Kayce; Knight, Katelin; Kalman, Douglas; Hewlings, Susan

2018-04-16

Coffee is a primary dietary source of the chlorogenic acids (CGAs) of phenolic compounds. Coffee contains caffeine and other phytonutrients, including CGAs. Caffeine on its own has been well characterized and descried pharmacokinetically in the literature, less so for CGAs. The purpose of this double-blind crossover study was to determine the comparative pharmacokinetics of CGAs with caffeine (natural extract) with synthetic caffeine (US Pharmacopeia [USP] standard). Sixteen healthy male subjects were randomly assigned to take 1 dose of product 1, 60 mg of botanically sourced caffeine from 480 mg of green coffee bean extract, or product 2, 60 mg of synthetic USP caffeine, with 5 days between. Blood analysis was done to determine the levels of CGA compounds, more specifically 3-, 4-, and 5-caffeoylquinic acid (CQA), and serum caffeine. The natural caffeine extract exhibited mean peak concentrations (C max ) of 3-CQA (11.4 ng/mL), 4-CQA (6.84 ng/mL), and 5-CQA (7.20 ng/mL). The mean systemic 4-hour exposure (AUC 0-4 h ) was 3-CQA (27.3 ng·h/mL), 4-CQA (16.1 ng·h/mL), and 5-CQA (15.7 ng·h/mL). The median t max was 3-CQA (1.00 hour), 4-CQA (1.00 hour), and 5-CQA (1.50 hours). The t max of caffeine was 0.75 hours (natural extract) and 0.63 hours (synthetic caffeine). C max and AUC 0-4 h of serum caffeine were statistically equivalent between products. The geometric least-squares mean ratios (GMRs) of C max and AUC 0-4 h of caffeine were 97.77% (natural extract) and 98.33% (synthetic caffeine). It would appear that CGA compounds from the natural caffeine extract are bioavailable, and 3-CGA may be the compound most absorbed. In addition, caffeine sourced from natural extract versus synthetic were statistically similar for pharmacokinetic parameters. There were no adverse events or safety concerns. © 2018 The Authors. Clinical Pharmacology in Drug Development Published by Wiley Periodicals, Inc. on behalf of The American College of Clinical Pharmacology.

A class of conservative Hamiltonians with exactly integrable discrete two-dimensional parametric maps

International Nuclear Information System (INIS)

Dikande, Alain M; Njumbe, E Epie

2010-01-01

A class of discrete conservative Hamiltonians with completely integrable two-dimensional (2D) mappings is constructed whose generic models are three families of non-integrable discrete Hamiltonians with on-site potentials whose double-well shapes vary. Unlike the discrete 2D mappings associated with the generic models, which all display pitchfork bifurcations towards randomly pinned states with chaotic features, for the derived models the pitchfork bifurcation leads to fixed points always surrounded by periodic trajectories. A nonlinear stability analysis reveals a finite crossover on the bifurcation line at which the pitchfork transition takes the maps from regular real periodic trajectories towards a regime dominated by a cluster of periodic point trajectories representing the allowed real solutions. The rich variety of structures displayed by the new class of discrete maps, combined with their complete integrability, offer rich perspectives for theoretical modelling of a wide class of systems undergoing structural instabilities without noticeable chaotic precursors.

Two Red Clumps and the X-shaped Milky Way Bulge

Science.gov (United States)

McWilliam, Andrew; Zoccali, Manuela

2010-12-01

From Two Micron All Sky Survey infrared photometry, we find two red clump (RC) populations coexisting in fields toward the Galactic bulge at latitudes |b|>5fdg5, ranging over ~13° in longitude and 20° in latitude. These RC peaks indicate two stellar populations separated by ~2.3 kpc at (l, b) = (+1, - 8) the two RCs are located at 6.5 and 8.8 ± 0.2 kpc. The double-peaked RC is inconsistent with a tilted bar morphology. Most of our fields show the two RCs at roughly constant distance with longitude, also inconsistent with a tilted bar; however, an underlying bar may be present. Stellar densities in the two RCs change dramatically with longitude: on the positive longitude side the foreground RC is dominant, while the background RC dominates negative longitudes. A line connecting the maxima of the foreground and background populations is tilted to the line of sight by ~20°±4°, similar to claims for the tilt of a Galactic bar. The distance between the two RCs decreases toward the Galactic plane; seen edge-on the bulge is X-shaped, resembling some extragalactic bulges and the results of N-body simulations. The center of this X is consistent with the distance to the Galactic center, although better agreement would occur if the bulge is 2-3 Gyr younger than 47 Tuc. Our observations may be understood if the two RC populations emanate, nearly tangentially, from the Galactic bar ends, in a funnel shape. Alternatively, the X, or double funnel, may continue to the Galactic center. From the Sun, this would appear peanut/box shaped, but X-shaped when viewed tangentially.

Simulation and Analysis of Autonomous Time Synchronization Based on Asynchronism Two-way Inter-satellite Link

Science.gov (United States)

Fang, L.; Yang, X. H.; Sun, B. Q.; Qin, W. J.; Kong, Y.

2013-09-01

The measurement of the inter-satellite link is one of the key techniques in the autonomous operation of satellite navigation system. Based on the asynchronism inter-satellite two-way measurement mode in GPS constellation, the reduction formula of the inter-satellite time synchronization is built in this paper. Moreover, the corrective method of main systematic errors is proposed. Inter-satellite two-way time synchronization is simulated on the basis of IGS (International GNSS Service) precise ephemeris. The impacts of the epoch domestication of asynchronism inter-satellite link pseudo-range, the initial orbit, and the main systematic errors on satellite time synchronization are analyzed. Furthermore, the broadcast clock error of each satellite is calculated by the ``centralized'' inter-satellite autonomous time synchronization. Simulation results show that the epoch domestication of asynchronism inter-satellite link pseudo-range and the initial orbit have little impact on the satellite clock errors, and thus they needn't be taken into account. The errors caused by the relativistic effect and the asymmetry of path travel have large impact on the satellite clock errors. These should be corrected with theoretical formula. Compared with the IGS precise clock error, the root mean square of the broadcast clock error of each satellite is about 0.4 ns.

Two-way coupled simulation of a flow laden with metallic particulates in overexpanded TIC nozzle

International Nuclear Information System (INIS)

Moshfegh, Abouzar; Shams, Mehrzad; Ebrahimi, Reza; Farnia, Mohammad Ali

2009-01-01

A simulation of non-reacting dilute gas-solid flow in a truncated ideal contour nozzle with consideration of external stream interactions is performed. The Eulerian-Lagrangian approach involving a two-way momentum and thermal coupling between gas and particles phases is also adopted. Of interests are to investigate the effects of particles diameter and mass flow fraction on the flow pattern, Mach number, pressure and temperature contours and their distributions along the nozzle centerline and wall. The main goal is to determine the separation point quantitatively when the particles characteristics change. Particles sample trajectories are illustrated throughout the flow field and a qualitative discussion on the way that physical properties of the nozzle exit flow and particles trajectories oscillate is prepared. The existence of solid particulates delays the separation prominently in the cases studied. The bigger particles and the higher particles mass flow fractions respectively advance and delay the separation occurrence. The particles trajectories oscillate when they expose to the crisscrossing (or diamond-shape) shock waves generated outside the nozzle to approach the exit jet conditions to the ambient. The simulation code is validated and verified, respectively, against a one-phase 2D convergent-divergent nozzle flow and a two-phase Jet Propulsion Laboratory nozzle flow, and acceptable agreements are achieved.

Comparative study of the two-phonon Raman bands of silicene and graphene

International Nuclear Information System (INIS)

Popov, Valentin N; Lambin, Philippe

2016-01-01

We present a computational study of the two-phonon Raman spectra of silicene and graphene within a density-functional non-orthogonal tight-binding model. Due to the presence of linear bands close to the Fermi energy in the electronic structure of both structures, the Raman scattering by phonons is resonant. We find that the Raman spectra exhibit a crossover behavior for laser excitation close to the π-plasmon energy. This phenomenon is explained by the disappearance of certain paths for resonant Raman scattering and the appearance of other paths beyond this energy. Besides that, the electronic joint density of states (DOS) is divergent at this energy, which is reflected on the behavior of the Raman bands of the two structures in a qualitatively different way. Additionally, a number of Raman bands, originating from divergent phonon DOS at the M point and at points, inside the Brillouin zone, is also predicted. The calculated spectra for graphene are in excellent agreement with available experimental data. The obtained Raman bands can be used for structural characterization of silicene and graphene samples by Raman spectroscopy. (paper)

Wegner-type Bounds for a Two-particle Lattice Model with a Generic 'Rough' Quasi-periodic Potential

International Nuclear Information System (INIS)

Gaume, Martin

2010-01-01

In this paper, we consider a class of two-particle tight-binding Hamiltonians, describing pairs of interacting quantum particles on the lattice Z d , d ≥ 1, subject to a common external potential V(x) which we assume quasi-periodic and depending on auxiliary parameters. Such parametric families of ergodic deterministic potentials ('grands ensembles') have been introduced earlier in Chulaevsky (2007), in the framework of single-particle lattice systems, where it was proved that a non-uniform analog of the Wegner bound holds true for a class of quasi-periodic grands ensembles. Using the approach proposed in Chulaevsky and Suhov (Commun Math Phys 283(2):479-489, 2008), we establish volume-dependent Wegner-type bounds for a class of quasi-periodic two-particle lattice systems with a non-random short-range interaction.

Two-dimensional NMR spectrometry

International Nuclear Information System (INIS)

Farrar, T.C.

1987-01-01

This article is the second in a two-part series. In part one (ANALYTICAL CHEMISTRY, May 15) the authors discussed one-dimensional nuclear magnetic resonance (NMR) spectra and some relatively advanced nuclear spin gymnastics experiments that provide a capability for selective sensitivity enhancements. In this article and overview and some applications of two-dimensional NMR experiments are presented. These powerful experiments are important complements to the one-dimensional experiments. As in the more sophisticated one-dimensional experiments, the two-dimensional experiments involve three distinct time periods: a preparation period, t 0 ; an evolution period, t 1 ; and a detection period, t 2

Two-way DF relaying assisted D2D communication: ergodic rate and power allocation

Science.gov (United States)

Ni, Yiyang; Wang, Yuxi; Jin, Shi; Wong, Kai-Kit; Zhu, Hongbo

2017-12-01

In this paper, we investigate the ergodic rate for a device-to-device (D2D) communication system aided by a two-way decode-and-forward (DF) relay node. We first derive closed-form expressions for the ergodic rate of the D2D link under asymmetric and symmetric cases, respectively. We subsequently discuss two special scenarios including weak interference case and high signal-to-noise ratio case. Then we derive the tight approximations for each of the considered scenarios. Assuming that each transmitter only has access to its own statistical channel state information (CSI), we further derive closed-form power allocation strategy to improve the system performance according to the analytical results of the ergodic rate. Furthermore, some insights are provided for the power allocation strategy based on the analytical results. The strategies are easy to compute and require to know only the channel statistics. Numerical results show the accuracy of the analysis results under various conditions and test the availability of the power allocation strategy.

TWO RED CLUMPS AND THE X-SHAPED MILKY WAY BULGE

International Nuclear Information System (INIS)

McWilliam, Andrew; Zoccali, Manuela

2010-01-01

From Two Micron All Sky Survey infrared photometry, we find two red clump (RC) populations coexisting in fields toward the Galactic bulge at latitudes |b|>5. 0 5, ranging over ∼13 0 in longitude and 20 0 in latitude. These RC peaks indicate two stellar populations separated by ∼2.3 kpc; at (l, b) = (+1, - 8) the two RCs are located at 6.5 and 8.8 ± 0.2 kpc. The double-peaked RC is inconsistent with a tilted bar morphology. Most of our fields show the two RCs at roughly constant distance with longitude, also inconsistent with a tilted bar; however, an underlying bar may be present. Stellar densities in the two RCs change dramatically with longitude: on the positive longitude side the foreground RC is dominant, while the background RC dominates negative longitudes. A line connecting the maxima of the foreground and background populations is tilted to the line of sight by ∼20 0 ±4 0 , similar to claims for the tilt of a Galactic bar. The distance between the two RCs decreases toward the Galactic plane; seen edge-on the bulge is X-shaped, resembling some extragalactic bulges and the results of N-body simulations. The center of this X is consistent with the distance to the Galactic center, although better agreement would occur if the bulge is 2-3 Gyr younger than 47 Tuc. Our observations may be understood if the two RC populations emanate, nearly tangentially, from the Galactic bar ends, in a funnel shape. Alternatively, the X, or double funnel, may continue to the Galactic center. From the Sun, this would appear peanut/box shaped, but X-shaped when viewed tangentially.

Robust distributed two-way relay beamforming in cognitive radio networks

KAUST Repository

Pandarakkottilil, Ubaidulla

2012-04-01

In this paper, we present distributed beamformer designs for a cognitive radio network (CRN) consisting of a pair of cognitive (or secondary) transceiver nodes communicating with each other through a set of secondary non-regenerative two-way relays. The secondary network shares the spectrum with a licensed primary user (PU), and operates under a constraint on the maximum interference to the PU, in addition to its own resource and quality of service (QoS) constraints. We propose beamformer designs assuming that the available channel state information (CSI) is imperfect, which reflects realistic scenarios. The performance of proposed designs is robust to the CSI errors. Such robustness is critical in CRNs given the difficulty in acquiring perfect CSI due to loose cooperation between the PUs and the secondary users (SUs), and the need for strict enforcement of PU interference limit. We consider a mean-square error (MSE)-constrained beamformer that minimizes the total relay transmit power and an MSE-balancing beamformer with a constraint on the total relay transmit power. We show that the proposed designs can be reformulated as convex optimization problems that can be solved efficiently. Through numerical simulations, we illustrate the improved performance of the proposed robust designs compared to non-robust designs. © 2012 IEEE.

A correction procedure for thermally two-way coupled point-particles

Science.gov (United States)

Horwitz, Jeremy; Ganguli, Swetava; Mani, Ali; Lele, Sanjiva

2017-11-01

Development of a robust procedure for the simulation of two-way coupled particle-laden flows remains a challenge. Such systems are characterized by O(1) or greater mass of particles relative to the fluid. The coupling of fluid and particle motion via a drag model means the undisturbed fluid velocity evaluated at the particle location (which is needed in the drag model) is no longer equal to the interpolated fluid velocity at the particle location. The same issue arises in problems of dispersed flows in the presence of heat transfer. The heat transfer rate to each particle depends on the difference between the particle's temperature and the undisturbed fluid temperature. We borrow ideas from the correction scheme we have developed for particle-fluid momentum coupling by developing a procedure to estimate the undisturbed fluid temperature given the disturbed temperature field created by a point-particle. The procedure is verified for the case of a particle settling under gravity and subject to radiation. The procedure is developed in the low Peclet, low Boussinesq number limit, but we will discuss the applicability of the same correction procedure outside of this regime when augmented by appropriate drag and heat exchange correlations. Supported by DOE, J. H. Supported by NSF GRF

Performance analysis of amplify-and-forward two-way relaying with co-channel interference and channel estimation error

KAUST Repository

Yang, Liang

2013-04-01

In this paper, we consider the performance of a two-way amplify-and-forward relaying network (AF TWRN) in the presence of unequal power co-channel interferers (CCI). Specifically, we consider AF TWRN with an interference-limited relay and two noisy-nodes with channel estimation error and CCI. We derive the approximate signal-to-interference plus noise ratio expressions and then use these expressions to evaluate the outage probability and error probability. Numerical results show that the approximate closed-form expressions are very close to the exact ones. © 2013 IEEE.

Source-receiver two-way wave extrapolation for prestack exploding-reflector modelling and migration

KAUST Repository

Alkhalifah, Tariq Ali

2014-10-08

Most modern seismic imaging methods separate input data into parts (shot gathers). We develop a formulation that is able to incorporate all available data at once while numerically propagating the recorded multidimensional wavefield forward or backward in time. This approach has the potential for generating accurate images free of artiefacts associated with conventional approaches. We derive novel high-order partial differential equations in the source-receiver time domain. The fourth-order nature of the extrapolation in time leads to four solutions, two of which correspond to the incoming and outgoing P-waves and reduce to the zero-offset exploding-reflector solutions when the source coincides with the receiver. A challenge for implementing two-way time extrapolation is an essential singularity for horizontally travelling waves. This singularity can be avoided by limiting the range of wavenumbers treated in a spectral-based extrapolation. Using spectral methods based on the low-rank approximation of the propagation symbol, we extrapolate only the desired solutions in an accurate and efficient manner with reduced dispersion artiefacts. Applications to synthetic data demonstrate the accuracy of the new prestack modelling and migration approach.

A comparative bioavailability study of two formulations of pregabalin in healthy Chilean volunteers.

Science.gov (United States)

Quiñones, Luis; Sasso, Jaime; Tamayo, Evelyn; Catalán, Johanna; González, Juan Paplo; Escala, Mario; Varela, Nelson; León, Jorge; Cáceres, Dante Daniel; Saavedra, Iván

2010-07-01

The aim of this study was to compare the pharmacokinetic parameters between two brands of pregabalin in healthy Chilean volunteers. A randomized, single-dose, two-period, two-sequence, crossover study design with a 2-week washout period was conducted in healthy Chilean males. Plasma samples were collected over a 12-hour period after administration of 150 mg pregabalin in each period. A validated ultra-performance liquid chromatography with positive ionization mass spectrometric detection method was used to analyze pregabalin concentration in plasma. Pharmacokinetic parameters were determined using a noncompartmental method. Bioequivalence between the test and reference products was determined when the ratio for the 90% confidence intervals (CIs) of the difference in the means of the log-transformed area under the curve (AUC)(0-t), AUC(0-∞), and maximum concentration (C(max)) of the two products were within 0.80 and 1.25. The study was carried out on 22 healthy Chilean volunteers. The mean (SD) C(max), AUC(0-t) and AUC(0-∞) of the test formulation (Pregobin™) of pregabalin were 2.10 (0.56) μg/ml, 10.35 (2.00) μgxh/ml and 13.92 (2.74) μgxh/ml, respectively. The mean (SD) C(max), AUC(0-t) and AUC(0-∞) of the reference formulation (Lyrica™) of pregabalin were 2.15 (0.52) μg/ml, 10.31 (1.85) μgxh/ml and 13.78 (2.25) μgxh/ml, respectively. The parametric 90% CIs for C(max), AUC(0-t), and AUC(0-∞) were 0.97-1.13, 1.01-1.04, and 0.98-1.02, respectively. These results suggest that both products are bioequivalent and can be used as interchangeable options in the clinical setting.

DMFC performance and methanol cross-over: Experimental analysis and model validation

Energy Technology Data Exchange (ETDEWEB)

Casalegno, A.; Marchesi, R. [Dipartimento di Energia, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)

2008-10-15

A combined experimental and modelling approach is proposed to analyze methanol cross-over and its effect on DMFC performance. The experimental analysis is performed in order to allow an accurate investigation of methanol cross-over influence on DMFC performance, hence measurements were characterized in terms of uncertainty and reproducibility. The findings suggest that methanol cross-over is mainly determined by diffusion transport and affects cell performance partly via methanol electro-oxidation at the cathode. The modelling analysis is carried out to further investigate methanol cross-over phenomenon. A simple model evaluates the effectiveness of two proposed interpretations regarding methanol cross-over and its effects. The model is validated using the experimental data gathered. Both the experimental analysis and the proposed and validated model allow a substantial step forward in the understanding of the main phenomena associated with methanol cross-over. The findings confirm the possibility to reduce methanol cross-over by optimizing anode feeding. (author)

A practical two-way system of quantum key distribution with untrusted source

International Nuclear Information System (INIS)

Chen Ming-Juan; Liu Xiang

2011-01-01

The most severe problem of a two-way 'plug-and-play' (p and p) quantum key distribution system is that the source can be controlled by the eavesdropper. This kind of source is defined as an “untrusted source . This paper discusses the effects of the fluctuation of internal transmittance on the final key generation rate and the transmission distance. The security of the standard BB84 protocol, one-decoy state protocol, and weak+vacuum decoy state protocol, with untrusted sources and the fluctuation of internal transmittance are studied. It is shown that the one-decoy state is sensitive to the statistical fluctuation but weak+vacuum decoy state is only slightly affected by the fluctuation. It is also shown that both the maximum secure transmission distance and final key generation rate are reduced when Alice's laboratory transmittance fluctuation is considered. (general)

QCD thermodynamics with two flavors of quarks

International Nuclear Information System (INIS)

Bernard, C.; Ogilvie, M.C.; DeGrand, T.A.; DeTar, C.; Gottlieb, S.; Krasnitz, A.; Sugar, R.L.; Toussaint, D.

1992-01-01

We present results of numerical simulations of quantum chromo-dynamics at finite temperature on the Intel iPSC/860 parallel processor. We performed calculations with two flavors of Kogut-Susskind quarks and of Wilson quarks on 6 x 12 3 lattices in order to study the crossover from the low temperature hadronic regime to the high temperature regime. We investigate the properties of the objects whose exchange gives static screening lengths by reconstructing their correlated quark-antiquark structure. (orig.)

Joint terminals and relay optimization for two-way power line information exchange systems with QoS constraints

Science.gov (United States)

Wu, Xiaolin; Rong, Yue

2015-12-01

The quality-of-service (QoS) criteria (measured in terms of the minimum capacity requirement in this paper) are very important to practical indoor power line communication (PLC) applications as they greatly affect the user experience. With a two-way multicarrier relay configuration, in this paper we investigate the joint terminals and relay power optimization for the indoor broadband PLC environment, where the relay node works in the amplify-and-forward (AF) mode. As the QoS-constrained power allocation problem is highly non-convex, the globally optimal solution is computationally intractable to obtain. To overcome this challenge, we propose an alternating optimization (AO) method to decompose this problem into three convex/quasi-convex sub-problems. Simulation results demonstrate the fast convergence of the proposed algorithm under practical PLC channel conditions. Compared with the conventional bidirectional direct transmission (BDT) system, the relay-assisted two-way information exchange (R2WX) scheme can meet the same QoS requirement with less total power consumption.

Artificial muscles made of chiral two-way shape memory polymer fibers

Science.gov (United States)

Yang, Qianxi; Fan, Jizhou; Li, Guoqiang

2016-10-01

In this work, we demonstrate the unusual improvement of the tensile actuation of hierarchically chiral structured artificial muscle made of two-way shape memory polymer (2W-SMP) fiber. Experimental results show that the chemically cross-linked poly(ethylene-co-vinyl acetate) 2W-SMP fibers possess an average negative coefficient of thermal expansion (NCTE) that is at least one order higher than that of the polyethylene fiber used previously. As expected, the increase in axial thermal contraction of the precursor fiber leads to an increase in the recovered torque ( 4.4 Nmm ) of the chiral fiber and eventually in the tensile actuation of the twisted-then-coiled artificial muscle ( 67.81 ±1.82 % ). A mechanical model based on Castigliano's second theorem is proposed, and the calculated result is consistent with the experimental result (64.17% tensile stroke). The model proves the significance of the NCTE and the recovered torque on tensile actuation of the artificial muscle and can be used as a guidance for the future design.

Investigation of Power Losses of Two-Stage Two-Phase Converter with Two-Phase Motor

Directory of Open Access Journals (Sweden)

Michal Prazenica

2011-01-01

Full Text Available The paper deals with determination of losses of two-stage power electronic system with two-phase variable orthogonal output. The simulation is focused on the investigation of losses in the converter during one period in steady-state operation. Modeling and simulation of two matrix converters with R-L load is shown in the paper. The simulation results confirm a very good time-waveform of the phase current and the system seems to be suitable for low-cost application in automotive/aerospace industries and in application with high frequency voltage sources.

Comparison of two ways for electric power production

International Nuclear Information System (INIS)

Sauze, A.

1993-01-01

The paper describes briefly the fusion reaction of hydrogen isotopes, the Tokamak reactor and the photovoltaic conversion from solar energy produced by the same fusion reaction. Then the development, the domain of application, the market and the financing of these two forms of energy are reviewed and compared

Hall Conductivity in a Quasi-Two-Dimensional Disordered Electron System

Institute of Scientific and Technical Information of China (English)

YANG Yong-Hong; WANG Yong-Gang; LIU Mei

2002-01-01

By making use of the diagrammatic techniques in perturbation theory,we have investigated the Hall effect in a quasi-two-dimensional disordered electron system.In the weakly localized regime,the analytical expression for quantum correction to Hall conductivity has been obtained using the Kubo formalism and quasiclassical approximation.The relevant dimensional crossover behavior from three dimensions to two dimensions with decreasing the interlayer hopping energy is discussed.The quantum interference effect is shown to have a vanishing correction t,o the Hall coefficient.

On the performance of spectrum sharing systems with two-way relaying and multiuser diversity

KAUST Repository

Yang, Liang

2012-08-01

In this letter, we consider a spectrum sharing network with two-way relaying and multi-user diversity. More specifically, one secondary transmitter with the best channel quality is selected and splits its partial power to relay its received signals to the primary users by using the amplify-and-forward relaying protocol. We derive a tight approximation for the resulting outage probability. Based on this formula, the performance of the spectral sharing region and the cell coverage are analyzed. Numerical results are given to verify our analysis and are discussed to illustrate the advantages of our newly proposed scheme. © 1997-2012 IEEE.

Orbital period variations of two W UMa-type binaries: UY UMa and EF Boo

Science.gov (United States)

Yu, Yun-Xia; Zhang, Xu-Dong; Hu, Ke; Xiang, Fu-Yuan

2017-08-01

The orbital period variations of two W UMa-type contact binaries, UY UMa and EF Boo, are analyzed by using all available times of light minimum. It is detected that the general trends of their (O - C) curves show an upward parabolic variation, which reveals their continuous period increases at the rates of dP / dt = 2.545 ×10-7 days yr-1 and dP / dt = 2.623 ×10-7 days yr-1 , respectively. Meanwhile, UY UMa also shows a cyclic period variation with a small amplitude of A = 0.0026 days superposed on the long-term increase. Due to their contact configurations, the secular period increases are interpreted as a result of mass transfer from the less massive component to the more massive one. The cyclic period variation of UY UMa may be interpreted in terms of either the magnetic activity or the light time effect.

Natural gas in a D. I. diesel engine. A comparison of two different ways. [Direct injection diesel enginer

Energy Technology Data Exchange (ETDEWEB)

Jun-ming, Qu; Sorenson, S.C.; Kofoed, E.

1987-01-01

A D.I. diesel engine was modified for natural gas operation with pilot injection and with spark ignition so that a comparative analysis of these two different ways of using natural gas could be made. The results of the experiments indicate that for a diesel engine, it is possible that the operating characteristics of a straight natural gas engine are comparable with those of a diesel/gas engine at the same compression ratio and speed. For a dual fuel engine with pilot injection the best diesel/gas ratio by energy content is approximately 20/80 at full load operation. For straight natural gas engine with spark ignition, quality governed natural gas operation has good efficiency but poor NOx emissions. This problem could be improved through throttle controlled operation. These two different ways of using natural gas are best suited to stationary engines.

Optimal relay selection and power allocation for cognitive two-way relaying networks

KAUST Repository

Pandarakkottilil, Ubaidulla

2012-06-01

In this paper, we present an optimal scheme for power allocation and relay selection in a cognitive radio network where a pair of cognitive (or secondary) transceiver nodes communicate with each other assisted by a set of cognitive two-way relays. The secondary nodes share the spectrum with a licensed primary user (PU), and each node is assumed to be equipped with a single transmit/receive antenna. The interference to the PU resulting from the transmission from the cognitive nodes is kept below a specified limit. We propose joint relay selection and optimal power allocation among the secondary user (SU) nodes achieving maximum throughput under transmit power and PU interference constraints. A closed-form solution for optimal allocation of transmit power among the SU transceivers and the SU relay is presented. Furthermore, numerical simulations and comparisons are presented to illustrate the performance of the proposed scheme. © 2012 IEEE.

Frequency-Modulated Wave Dielectrophoresis of Vesicles And Cells: Periodic U-Turns at the Crossover Frequency

Science.gov (United States)

Frusawa, Hiroshi

2018-06-01

We have formulated the dielectrophoretic force exerted on micro/nanoparticles upon the application of frequency-modulated (FM) electric fields. By adjusting the frequency range of an FM wave to cover the crossover frequency f X in the real part of the Clausius-Mossotti factor, our theory predicts the reversal of the dielectrophoretic force each time the instantaneous frequency periodically traverses f X . In fact, we observed periodic U-turns of vesicles, leukemia cells, and red blood cells that undergo FM wave dielectrophoresis (FM-DEP). It is also suggested by our theory that the video tracking of the U-turns due to FM-DEP is available for the agile and accurate measurement of f X . The FM-DEP method requires a short duration, less than 30 s, while applying the FM wave to observe several U-turns, and the agility in measuring f X is of much use for not only salty cell suspensions but also nanoparticles because the electric-field-induced solvent flow is suppressed as much as possible. The accuracy of f X has been verified using two types of experiment. First, we measured the attractive force exerted on a single vesicle experiencing alternating-current dielectrophoresis (AC-DEP) at various frequencies of sinusoidal electric fields. The frequency dependence of the dielectrophoretic force yields f X as a characteristic frequency at which the force vanishes. Comparing the AC-DEP result of f X with that obtained from the FM-DEP method, both results of f X were found to coincide with each other. Second, we investigated the conductivity dependencies of f X for three kinds of cell by changing the surrounding electrolytes. From the experimental results, we evaluated simultaneously both of the cytoplasmic conductivities and the membrane capacitances using an elaborate theory on the single-shell model of biological cells. While the cytoplasmic conductivities, similar for these cells, were slightly lower than the range of previous reports, the membrane capacitances obtained

QCD thermodynamics with two flavors of quarks

Energy Technology Data Exchange (ETDEWEB)

Bernard, C.; Ogilvie, M.C. (Washington Univ., Saint Louis, MO (United States). Dept. of Physics); DeGrand, T.A. (Colorado Univ., Boulder, CO (United States). Physics Dept.); DeTar, C. (Utah Univ., Salt Lake City, UT (United States). Physics Dept.); Gottlieb, S.; Krasnitz, A. (Indiana Univ., Bloomington, IN (United States). Dept. of Physics); Sugar, R.L. (California Univ., Santa Barbara, CA (United States). Dept. of Physics); Toussaint, D. (Arizona Univ., Tucson, AZ (United States). Dept. of Physics); MIMD Lattice Computations (MILC) Collaboration

1992-05-01

We present results of numerical simulations of quantum chromo-dynamics at finite temperature on the Intel iPSC/860 parallel processor. We performed calculations with two flavors of Kogut-Susskind quarks and of Wilson quarks on 6 x 12[sup 3] lattices in order to study the crossover from the low temperature hadronic regime to the high temperature regime. We investigate the properties of the objects whose exchange gives static screening lengths by reconstructing their correlated quark-antiquark structure. (orig.).

Comparative study between EDXRF and ASTM E572 methods using two-way ANOVA

Science.gov (United States)

Krummenauer, A.; Veit, H. M.; Zoppas-Ferreira, J.

2018-03-01

Comparison with reference method is one of the necessary requirements for the validation of non-standard methods. This comparison was made using the experiment planning technique with two-way ANOVA. In ANOVA, the results obtained using the EDXRF method, to be validated, were compared with the results obtained using the ASTM E572-13 standard test method. Fisher's tests (F-test) were used to comparative study between of the elements: molybdenum, niobium, copper, nickel, manganese, chromium and vanadium. All F-tests of the elements indicate that the null hypothesis (Ho) has not been rejected. As a result, there is no significant difference between the methods compared. Therefore, according to this study, it is concluded that the EDXRF method was approved in this method comparison requirement.

Dealing with Activism in Canada: An Ideal Cultural Fit for the Two-Way Symmetrical Public Relations Model.

Science.gov (United States)

Guiniven, John E.

2002-01-01

Notes that disputes are seen as much less confrontational, much less zero-sum games in Canada than in the United States. Interviews 15 communications and public relations practitioners and professors with experiences on both sides of the 49th parallel and reviews relevant literature. Concludes that the greater acceptance of two-way symmetrical…

Meaning Making and Translanguaging in a Two-Way Dual-Language Program on the U.S.-Mexico Border

Science.gov (United States)

Esquinca, Alberto; Araujo, Blanca; de la Piedra, María Teresa

2014-01-01

The article analyzes meaning-making practices in a two-way dual-language (TWDL) program on the U.S.-Mexico border among "transfronterizo" and Mexican-origin youth. In the article, we show that emergent bilingual learners and their teacher participate in activities that mediate understanding of science content knowledge. We show how the…

Magnetoresistance calculations for a two-dimensional electron gas with unilateral short-period strong modulation

Czech Academy of Sciences Publication Activity Database

Výborný, Karel; Smrčka, Ludvík

2002-01-01

Roč. 66, č. 20 (2002), s. 205318-1 - 205318-8 ISSN 0163-1829 R&D Projects: GA ČR GA202/01/0754 Institutional research plan: CEZ:AV0Z1010914 Keywords : magnetoresistance * short-period superlattices * two-dimensional electron gas Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 3.327, year: 2002

Observation of the two-way shape memory effect in an atomistic model of martensitic transformation

Directory of Open Access Journals (Sweden)

Eduardo Jagla

2017-05-01

Full Text Available We study a system of classical particles in two dimensions interacting through an isotropic pair potential that displays a martensitic phase transition between a triangular and a rhomboidal structure upon the change of a single parameter. Previously it was shown that this potential is able to reproduce the shape memory effect and super-elasticity, among other well known features of the phenomenology of martensites. Here we extend those previous studies and describe the development of the more subtle two-way shape memory effect. We show that in a poly-crystalline sample, the effect is mostly due to the existence of retained martensite within the austenite phase. We also study the case of a single crystal sample where the effect is associated to particular orientations of the dislocations, either induced by training or by an ad hoc construction of a starting sample.

Two-body correlation functions in dilute nuclear matter

International Nuclear Information System (INIS)

Isayev, A A

2006-01-01

Finding the distinct features of the crossover from the regime of large overlapping Cooper pairs to the limit of non-overlapping pairs of fermions (Shafroth pairs) in multicomponent Fermi systems remains one of the actual problems in a quantum many-body theory. Here this transition is studied by calculating the two-body density, spin and isospin correlation functions in dilute asymmetric nuclear matter. It is shown that criterion of the crossover (Phys. Rev. Lett. 95, 090402 (2005)), consisting in the change of the sign of the density correlation function at low momentum transfer, fails to describe correctly the density-driven BEC-BCS transition at finite isospin asymmetry or finite temperature. As an unambiguous signature of the BEC-BCS transition, there can be used the presence (BCS regime) or absence (BEC regime) of the singularity in the momentum distribution of the quasiparticle density of states

Multi-pair cognitive two-way relaying and power allocation under imperfect CSI

KAUST Repository

Pandarakkottilil, Ubaidulla; Alouini, Mohamed-Slim; Aï ssa, Sonia

2013-01-01

In this paper, we present a robust joint relay precoder design and transceiver power allocation for a cognitive radio network under imperfect channel state information. The secondary (or cognitive) network consists of multiple pairs of single-antenna transceiver nodes and a non-regenerative two-way relay with multiple antennas which aids the intra-pair communication process of the transceiver nodes. The secondary nodes share the spectrum with a licensed primary user (PU) while guaranteeing that the interference to the PU receiver is maintained below a specified threshold. The proposed robust design is based on the minimization of the sum mean-square error (MSE) of the transceiver nodes under constraints on the secondary users' transmit powers and interference to PU the receiver. Though the original problem is non-convex, we show that the proposed design can be solved using alternating optimization of convex subproblems which have analytic or efficient numerical solutions. We illustrate the performance of the proposed designs through some selected numerical simulations. © 2013 IEEE.

Multi-pair cognitive two-way relaying and power allocation under imperfect CSI

KAUST Repository

Pandarakkottilil, Ubaidulla

2013-06-01

In this paper, we present a robust joint relay precoder design and transceiver power allocation for a cognitive radio network under imperfect channel state information. The secondary (or cognitive) network consists of multiple pairs of single-antenna transceiver nodes and a non-regenerative two-way relay with multiple antennas which aids the intra-pair communication process of the transceiver nodes. The secondary nodes share the spectrum with a licensed primary user (PU) while guaranteeing that the interference to the PU receiver is maintained below a specified threshold. The proposed robust design is based on the minimization of the sum mean-square error (MSE) of the transceiver nodes under constraints on the secondary users\\' transmit powers and interference to PU the receiver. Though the original problem is non-convex, we show that the proposed design can be solved using alternating optimization of convex subproblems which have analytic or efficient numerical solutions. We illustrate the performance of the proposed designs through some selected numerical simulations. © 2013 IEEE.

Cognitive two-way relay beamforming: Design with resilience to channel state uncertainties

KAUST Repository

Ubaidulla, P.

2016-07-26

In this paper, we propose a robust distributed relay beamformer design for cognitive radio network operating under uncertainties in the available channel state information. The cognitive network consists of a pair of transceivers and a set of non-regenerative two-way relays that assist the communication between the transceiver pair. The secondary nodes share the spectrum with a licensed primary user node while ensuring that the interference to the primary receiver is maintained below a certain threshold. The proposed robust design maximizes the worst-case signal-to-interference-plus-noise ratio at the secondary transceivers while satisfying constraints on the interference to the primary user and on the total relay transmit power. Though the robust design problem is not a convex problem in its original form, we show that it can be reformulated as a convex optimization problem, which can be solved efficiently. Numerical results are provided and illustrate the merits of the proposed design for various operating conditions and parameters. © 2016 IEEE.

Dimensional BCS-BEC crossover in ultracold Fermi gases

Energy Technology Data Exchange (ETDEWEB)

Boettcher, Igor

2014-12-10

We investigate thermodynamics and phase structure of ultracold Fermi gases, which can be realized and measured in the laboratory with modern trapping techniques. We approach the subject from a both theoretical and experimental perspective. Central to the analysis is the systematic comparison of the BCS-BEC crossover of two-component fermions in both three and two dimensions. A dimensional reduction can be achieved in experiments by means of highly anisotropic traps. The Functional Renormalization Group (FRG) allows for a description of both cases in a unified theoretical framework. In three dimensions we discuss with the FRG the influence of high momentum particles onto the density, extend previous approaches to the Unitary Fermi Gas to reach quantitative precision, and study the breakdown of superfluidity due to an asymmetry in the population of the two fermion components. In this context we also investigate the stability of the Sarma phase. For the two-dimensional system scattering theory in reduced dimension plays an important role. We present both the theoretically as well as experimentally relevant aspects thereof. After a qualitative analysis of the phase diagram and the equation of state in two dimensions with the FRG we describe the experimental determination of the phase diagram of the two-dimensional BCS-BEC crossover in collaboration with the group of S. Jochim at PI Heidelberg.

PERIODIC REVIEW SYSTEM FOR INVENTORY REPLENISHMENT CONTROL FOR A TWO-ECHELON LOGISTICS NETWORK UNDER DEMAND UNCERTAINTY: A TWO-STAGE STOCHASTIC PROGRAMING APPROACH

Directory of Open Access Journals (Sweden)

P.S.A. Cunha

Full Text Available ABSTRACT Here, we propose a novel methodology for replenishment and control systems for inventories of two-echelon logistics networks using a two-stage stochastic programming, considering periodic review and uncertain demands. In addition, to achieve better customer services, we introduce a variable rationing rule to address quantities of the item in short. The devised models are reformulated into their deterministic equivalent, resulting in nonlinear mixed-integer programming models, which are then approximately linearized. To deal with the uncertain nature of the item demand levels, we apply a Monte Carlo simulation-based method to generate finite and discrete sets of scenarios. Moreover, the proposed approach does not require restricted assumptions to the behavior of the probabilistic phenomena, as does several existing methods in the literature. Numerical experiments with the proposed approach for randomly generated instances of the problem show results with errors around 1%.

All-optical two-way relaying free-space optical communications for HAP-based broadband backhaul networks

Science.gov (United States)

Vu, Minh Q.; Nguyen, Nga T. T.; Pham, Hien T. T.; Dang, Ngoc T.

2018-03-01

High-altitude platforms (HAPs) are flexible, non-pollutant and cost-effective infrastructures compared to satellite or old terrestrial systems. They are being researched and developed widely in Europe, USA, Japan, Korea, and so on. However, the current limited data rates and the overload of radio frequency (RF) spectrum are problems which the developers for HAPs are confronting because most of them use RF links to communicate with the ground stations (GSs) or each other. In this paper, we propose an all-optical two-way half-duplex relaying free-space optical (FSO) communication for HAP-based backhaul networks, which connect the base transceiver station (BTS) to the core network (CN) via a single HAP. Our proposed backhaul solution can be deployed quickly and flexibly for disaster relief and for serving users in both urban environments and remote areas. The key subsystem of HAP is an optical regenerate-and-forward (ORF) equipped with an optical hard-limiter (OHL) and an optical XOR gate to perform all-optical processing and help mitigate the background noise. In addition, two-way half-duplex relaying can be provided thanks to the use of network coding scheme. The closed-form expression for the bit error rate (BER) of our proposed system under the effect of path loss, atmospheric turbulence, and noise induced by the background light is formulated. The numerical results are demonstrated to prove the feasibility of our proposed system with the verification by using Monte-Carlo (M-C) simulations.

Application of high-precision two-way ranging to Galileo Earth-1 encounter navigation

Science.gov (United States)

Pollmeier, V. M.; Thurman, S. W.

1992-01-01

The application of precision two-way ranging to orbit determination with relatively short data arcs is investigated for the Galileo spacecraft's approach to its first Earth encounter (December 8, 1990). Analysis of previous S-band (2.3-GHz) ranging data acquired from Galileo indicated that under good signal conditions submeter precision and 10-m ranging accuracy were achieved. It is shown that ranging data of sufficient accuracy, when acquired from multiple stations, can sense the geocentric angular position of a distant spacecraft. A range data filtering technique, in which explicit modeling of range measurement bias parameters for each station pass is utilized, is shown to largely remove the systematic ground system calibration errors and transmission media effects from the Galileo range measurements, which would otherwise corrupt the angle-finding capabilities of the data. The accuracy of the Galileo orbit solutions obtained with S-band Doppler and precision ranging were found to be consistent with simple theoretical calculations, which predicted that angular accuracies of 0.26-0.34 microrad were achievable. In addition, the navigation accuracy achieved with precision ranging was marginally better than that obtained using delta-differenced one-way range (delta DOR), the principal data type that was previously used to obtain spacecraft angular position measurements operationally.

Crossover ensembles of random matrices and skew-orthogonal polynomials

International Nuclear Information System (INIS)

Kumar, Santosh; Pandey, Akhilesh

2011-01-01

Highlights: → We study crossover ensembles of Jacobi family of random matrices. → We consider correlations for orthogonal-unitary and symplectic-unitary crossovers. → We use the method of skew-orthogonal polynomials and quaternion determinants. → We prove universality of spectral correlations in crossover ensembles. → We discuss applications to quantum conductance and communication theory problems. - Abstract: In a recent paper (S. Kumar, A. Pandey, Phys. Rev. E, 79, 2009, p. 026211) we considered Jacobi family (including Laguerre and Gaussian cases) of random matrix ensembles and reported exact solutions of crossover problems involving time-reversal symmetry breaking. In the present paper we give details of the work. We start with Dyson's Brownian motion description of random matrix ensembles and obtain universal hierarchic relations among the unfolded correlation functions. For arbitrary dimensions we derive the joint probability density (jpd) of eigenvalues for all transitions leading to unitary ensembles as equilibrium ensembles. We focus on the orthogonal-unitary and symplectic-unitary crossovers and give generic expressions for jpd of eigenvalues, two-point kernels and n-level correlation functions. This involves generalization of the theory of skew-orthogonal polynomials to crossover ensembles. We also consider crossovers in the circular ensembles to show the generality of our method. In the large dimensionality limit, correlations in spectra with arbitrary initial density are shown to be universal when expressed in terms of a rescaled symmetry breaking parameter. Applications of our crossover results to communication theory and quantum conductance problems are also briefly discussed.

Forty-two

Directory of Open Access Journals (Sweden)

John Dumay

2015-01-01

Full Text Available This article explores the meaning and context of intellectual capital (IC numbers to help break free from the domination of IC “accountingisation” . Offering a personal and reflective narrative about IC numbers, I first discuss what numbers mean by exploring the way we think about the number 42. This discussion is followed by two empirical sections examining the meaning and context of a common IC measure, employee turnover rates. Measuring any IC element is problematic from an IC accounting perspective because of the unique context in which each organization operates. The comparability of a number from one organization and one period with another is nearly impossible. The article is original because it takes a thought-provoking narrative journey into the use and meaning of applying IC numbers. It is a personal reflection on the implications of considering the meaning of numbers for IC practice, IC education and research, and IC’s future. It is particularly topical in light of the inclusion of IC in the recent Integrated Reporting ( Guidelines.

Short-term effects of crossover treatment with silodosin and tamsulosin hydrochloride for lower urinary tract symptoms associated with benign prostatic hyperplasia.

Science.gov (United States)

Miyakita, Hideshi; Yokoyama, Eiji; Onodera, Yasutada; Utsunomiya, Takuji; Tokunaga, Masatoshi; Tojo, Takanori; Fujii, Noriteru; Yanada, Shuichi

2010-10-01

To compare the efficacy and safety of silodosin and tamsulosin in patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) by a randomized crossover method. BPH patients with the complaint of LUTS were included in this study, and were randomly divided into two groups: a silodosin-preceding group (4 weeks of twice-daily administration of silodosin at 4 mg, followed by 4 weeks of once-daily administration of tamsulosin at 0.2 mg) or a tamsulosin-preceding group (4 weeks' administration of tamsulosin, followed by 4 weeks' administration of silodosin). No drug withdrawal period was provided when switching the drug. In the first treatment period, both drugs significantly improved the International Prostate Symptom Score total score, but the improvement by silodosin was significantly superior to that by tamsulosin. After crossover treatment, significant improvement was observed only with silodosin treatment. Moreover, intergroup comparison of changes revealed that silodosin showed significant improvement of straining and nocturia with first and crossover treatments, respectively, compared with tamsulosin. Silodosin also significantly improved quality of life (QOL) score in both treatment periods, while tamsulosin significantly improved QOL score only in the first treatment period. The most frequent adverse drug reaction was ejaculatory disorder with silodosin; however, the incidence of dizziness with silodosin was similar to that with tamsulosin. In BPH/LUTS patients, silodosin exhibits excellent efficacy in improving subjective symptoms in both initial and crossover treatment, and it appears to improve the QOL of patients. © 2010 The Japanese Urological Association.

Two Novel Methods and Multi-Mode Periodic Solutions for the Fermi-Pasta-Ulam Model

Science.gov (United States)

Arioli, Gianni; Koch, Hans; Terracini, Susanna

2005-04-01

We introduce two novel methods for studying periodic solutions of the FPU β-model, both numerically and rigorously. One is a variational approach, based on the dual formulation of the problem, and the other involves computer-assisted proofs. These methods are used e.g. to construct a new type of solutions, whose energy is spread among several modes, associated with closely spaced resonances.

The direct field boundary impedance of two-dimensional periodic structures with application to high frequency vibration prediction.

Science.gov (United States)

Langley, Robin S; Cotoni, Vincent

2010-04-01

Large sections of many types of engineering construction can be considered to constitute a two-dimensional periodic structure, with examples ranging from an orthogonally stiffened shell to a honeycomb sandwich panel. In this paper, a method is presented for computing the boundary (or edge) impedance of a semi-infinite two-dimensional periodic structure, a quantity which is referred to as the direct field boundary impedance matrix. This terminology arises from the fact that none of the waves generated at the boundary (the direct field) are reflected back to the boundary in a semi-infinite system. The direct field impedance matrix can be used to calculate elastic wave transmission coefficients, and also to calculate the coupling loss factors (CLFs), which are required by the statistical energy analysis (SEA) approach to predicting high frequency vibration levels in built-up systems. The calculation of the relevant CLFs enables a two-dimensional periodic region of a structure to be modeled very efficiently as a single subsystem within SEA, and also within related methods, such as a recently developed hybrid approach, which couples the finite element method with SEA. The analysis is illustrated by various numerical examples involving stiffened plate structures.

A Novel Secure Transmission Scheme in MIMO Two-Way Relay Channels with Physical Layer Approach

Directory of Open Access Journals (Sweden)

Qiao Liu

2017-01-01

Full Text Available Security issue has been considered as one of the most pivotal aspects for the fifth-generation mobile network (5G due to the increasing demands of security service as well as the growing occurrence of security threat. In this paper, instead of focusing on the security architecture in the upper layer, we investigate the secure transmission for a basic channel model in a heterogeneous network, that is, two-way relay channels. By exploiting the properties of the transmission medium in the physical layer, we propose a novel secure scheme for the aforementioned channel mode. With precoding design, the proposed scheme is able to achieve a high transmission efficiency as well as security. Two different approaches have been introduced: information theoretical approach and physical layer encryption approach. We show that our scheme is secure under three different adversarial models: (1 untrusted relay attack model, (2 trusted relay with eavesdropper attack model, and (3 untrusted relay with eavesdroppers attack model. We also derive the secrecy capacity of the two different approaches under the three attacks. Finally, we conduct three simulations of our proposed scheme. The simulation results agree with the theoretical analysis illustrating that our proposed scheme could achieve a better performance than the existing schemes.

QCD thermodynamics with two flavors of quarks[1

Science.gov (United States)

MIMD lattice Computations (MILC) Collaboration

We present results of numerical simulations of quantum chromodynamics at finite temperature on the Intel iPSC/860 parallel processor. We performed calculations with two flavors of Kogut-Susskind quarks and of Wilson quarks on 6 × 12 3 lattices in order to study the crossover from the low temperature hadronic regime to the high temperature regime. We investigate the properties of the objects whose exchange gives static screening lengths be reconstructing their correlated quark-antiquark structure.

Two-Way Multiple Relays Channel: Achievable Rate Region and Optimal Resources

Directory of Open Access Journals (Sweden)

Zouhair Al-Qudah

2016-01-01

Full Text Available This paper considers a communication model containing two users that exchange their information with the help of multiple parallel relay nodes. To avoid interference at these common nodes, two users are required to transmit over the different frequency bands. Based on this scenario, the achievable rate region is initially derived. Next, an optimization scheme is described to choose the best relays that can be used by each user. Then, two power allocation optimization schemes are investigated to allocate the proper average power value to each node. Finally, comparisons between these two optimization schemes are carried out through some numerical examples.

Pressure effect on hysteresis in spin-crossover solid materials

Energy Technology Data Exchange (ETDEWEB)

Gudyma, Iurii, E-mail: yugudyma@gmail.com [Department of General Physics, Chernivtsi National University, Chernivtsi 58012 (Ukraine); Ivashko, Victor [Department of General Physics, Chernivtsi National University, Chernivtsi 58012 (Ukraine); Dimian, Mihai [Department of Electrical and Computer Engineering, Howard University, Washington DC 20059 (United States); Faculty of Electrical Engineering and Computer Science & Integrated Center for Research, Development and Innovation in Advanced Materials, Nanotechnologies, and Distributed Systems for fabrication and control, Stefan cel Mare University, Suceava 720229 (Romania)

2016-04-01

A generalized microscopic Ising-like model is proposed to describe behavior of compressible spin-crossover solids with two states: low-spin and high-spin. The model was solved in mean-field approximation and shows hysteretic behavior at low energy difference between the states. We study the thermal transition between states under external hydrostatic pressure taking into account the changes in the volume of spin-crossover molecules in different states. Depending on the applied pressure, a spin-crossover system can have three types of behavior of molecular fraction in the high-spin state: hysteretic, second-order phase transition and no-phase transition. For the hysteretic regime, it is shown that the transition temperature under pressure is increased while the width of the hysteresis reduced.

Audiovisual distraction for pain relief in paediatric inpatients: A crossover study.

Science.gov (United States)

Oliveira, N C A C; Santos, J L F; Linhares, M B M

2017-01-01

Pain is a stressful experience that can have a negative impact on child development. The aim of this crossover study was to examine the efficacy of audiovisual distraction for acute pain relief in paediatric inpatients. The sample comprised 40 inpatients (6-11 years) who underwent painful puncture procedures. The participants were randomized into two groups, and all children received the intervention and served as their own controls. Stress and pain-catastrophizing assessments were initially performed using the Child Stress Scale and Pain Catastrophizing Scale for Children, with the aim of controlling these variables. The pain assessment was performed using a Visual Analog Scale and the Faces Pain Scale-Revised after the painful procedures. Group 1 received audiovisual distraction before and during the puncture procedure, which was performed again without intervention on another day. The procedure was reversed in Group 2. Audiovisual distraction used animated short films. A 2 × 2 × 2 analysis of variance for 2 × 2 crossover study was performed, with a 5% level of statistical significance. The two groups had similar baseline measures of stress and pain catastrophizing. A significant difference was found between periods with and without distraction in both groups, in which scores on both pain scales were lower during distraction compared with no intervention. The sequence of exposure to the distraction intervention in both groups and first versus second painful procedure during which the distraction was performed also significantly influenced the efficacy of the distraction intervention. Audiovisual distraction effectively reduced the intensity of pain perception in paediatric inpatients. The crossover study design provides a better understanding of the power effects of distraction for acute pain management. Audiovisual distraction was a powerful and effective non-pharmacological intervention for pain relief in paediatric inpatients. The effects were

Training and two-way shape memory in NiTi alloys: influence on thermal parameters

International Nuclear Information System (INIS)

Lahoz, R.; Puertolas, J.A.

2004-01-01

The two-way shape memory effect (TWSME) was studied in a near equiatomic commercial alloy. A training procedure based on a constant load applied in the temperature range of the parent → martensite transformation was carried out on NiTi wires. The efficiency of the method was determined from deformation-temperature measurements by MTA at different training stress and number of cycles. A maximum of two shape memory strain was obtained for a stress training of 115 MPa, independently of number of training cycles. A correlation was established between the TWSME arisen and the permanent strain generated during the training. The A s and A f transitions present a positive shift and the M s and M f a negative one with increasing training stress. All the transitions temperatures decrease with the training cycling. In the trained material, the P→M and M→P temperatures and the latent heat of these conversions undergoes a strong decrease with increasing training stress, with a strong asymmetry between the forward and the reversed transitions. The changes of these thermal parameters as a function of the training parameters were studied on a thermodynamic frame

Two-rate periodic protocol with dynamics driven through many cycles

Science.gov (United States)

Kar, Satyaki

2017-02-01

We study the long time dynamics in closed quantum systems periodically driven via time dependent parameters with two frequencies ω1 and ω2=r ω1 . Tuning of the ratio r there can unleash plenty of dynamical phenomena to occur. Our study includes integrable models like Ising and X Y models in d =1 and the Kitaev model in d =1 and 2 and can also be extended to Dirac fermions in graphene. We witness the wave-function overlap or dynamic freezing that occurs within some small/ intermediate frequency regimes in the (ω1,r ) plane (with r ≠0 ) when the ground state is evolved through a single cycle of driving. However, evolved states soon become steady with long driving, and the freezing scenario gets rarer. We extend the formalism of adiabatic-impulse approximation for many cycle driving within our two-rate protocol and show the near-exact comparisons at small frequencies. An extension of the rotating wave approximation is also developed to gather an analytical framework of the dynamics at high frequencies. Finally we compute the entanglement entropy in the stroboscopically evolved states within the gapped phases of the system and observe how it gets tuned with the ratio r in our protocol. The minimally entangled states are found to fall within the regime of dynamical freezing. In general, the results indicate that the entanglement entropy in our driven short-ranged integrable systems follow a genuine nonarea law of scaling and show a convergence (with a r dependent pace) towards volume scaling behavior as the driving is continued for a long time.

Approximating the Ising model on fractal lattices of dimension less than two

DEFF Research Database (Denmark)

Codello, Alessandro; Drach, Vincent; Hietanen, Ari

2015-01-01

We construct periodic approximations to the free energies of Ising models on fractal lattices of dimension smaller than two, in the case of a zero external magnetic field, based on the combinatorial method of Feynman and Vdovichenko. We show that the procedure is applicable to any fractal obtained...... with, possibly, arbitrary accuracy and paves the way for determination Tc of any fractal of dimension less than two. Critical exponents are more diffcult to determine since the free energy of any periodic approximation still has a logarithmic singularity at the critical point implying α = 0. We also...

Challenging the One-Way Paradigm for More Effective Science Communication: A Critical Review of Two Public Campaigns Addressing Contentious Environmental Issues

Science.gov (United States)

McEntee, Marie; Mortimer, Claire

2013-01-01

This article examines two large-scale public communication campaigns to explore the appropriateness and effectiveness of using one-way communication in contentious environmental issues. The findings show while one-way communication can be successfully employed in contentious issues, it is not appropriate for all contexts and may contribute to…

Bioavailability of two oral formulations of triazolam using radioreceptor assay

Energy Technology Data Exchange (ETDEWEB)

Lapka, R; Cepelakova, H; Rejholec, V; Franc, Z

1986-04-01

The radioreceptor assay (RRA) was used to quantitate plasma triazolam concentration in eight female volunteers following single 0.5 mg doses of two tablet formulations in a cross-over study. Bioavailability in terms of area under the plasma concentration versus time curve, maximum plasma concentration, time to maximum, and mean residence time was not statistically significantly different from one formulation to the other.

Outage Performance of Decode-and-Forward in Two-Way Relaying with Outdated CSI

KAUST Repository

Hyadi, Amal

2015-01-07

In this paper, we analyze the outage behavior of decode-and-forward relaying in the context of selective two-way cooperative systems. First, a new relay selection metric is proposed to take into consideration both transmission rates and instantaneous link conditions between cooperating nodes. Afterwards, the outage probability of the proposed system is derived for Nakagami-m fading channels in the case when perfect channel state information is available and then extended to the more realistic scenario where the available channel state information (CSI) is outdated due to fast fading. New expressions for the outage probability are obtained, and the impact of imperfect CSI on the performance is evaluated. Illustrative numerical results, Monte Carlo simulations, and comparisons with similar approaches are presented to assess the accuracy of our analytical derivations and confirm the performance gain of the proposed scheme.

Evaluation of two dairy herd reproductive performance indicators that are adjusted for voluntary waiting period

Directory of Open Access Journals (Sweden)

Löf Emma

2012-01-01

Full Text Available Abstract Background Overall reproductive performance of dairy herds is monitored by various indicators. Most of them do not consider all eligible animals and do not consider different management strategies at farm level. This problem can be alleviated by measuring the proportion of pregnant cows by specific intervals after their calving date or after a fixed time period, such as the voluntary waiting period. The aim of this study was to evaluate two reproductive performance indicators that consider the voluntary waiting period at the herd. The two indicators were: percentage of pregnant cows in the herd after the voluntary waiting period plus 30 days (PV30 and percentage of inseminated cows in the herd after the voluntary waiting period plus 30 days (IV30. We wanted to assess how PV30 and IV30 perform in a simulation of herds with different reproductive management and physiology and to compare them to indicators of reproductive performance that do not consider the herd voluntary waiting period. Methods To evaluate the reproductive indicators we used the SimHerd-program, a stochastic simulation model, and 18 scenarios were simulated. The scenarios were designed by altering the reproductive management efficiency and the status of reproductive physiology of the herd. Logistic regression models, together with receiver operating characteristics (ROC, were used to examine how well the reproductive performance indicators could discriminate between herds of different levels of reproductive management efficiency or reproductive physiology. Results The logistic regression models with the ROC analysis showed that IV30 was the indicator that best discriminated between different levels of management efficiency followed by PV30, calving interval, 200-days not-in calf-rate (NotIC200, in calf rate at100-days (IC100 and a fertility index. For reproductive physiology the ROC analysis showed that the fertility index was the indicator that best discriminated

Improved long-term outcomes after resection of pancreatic adenocarcinoma: a comparison between two time periods.

Science.gov (United States)

Serrano, Pablo E; Cleary, Sean P; Dhani, Neesha; Kim, Peter T W; Greig, Paul D; Leung, Kenneth; Moulton, Carol-Anne; Gallinger, Steven; Wei, Alice C

2015-04-01

Despite reduced perioperative mortality and routine use of adjuvant therapy following pancreatectomy for pancreatic ductal adenocarcinoma (PDAC), improvement in long-term outcome has been difficult to ascertain. This study compares outcomes in patients undergoing resection for PDAC within a single, high-volume academic institution over two sequential time periods. Retrospective review of patients with resected PDAC, in two cohorts: period 1 (P1), 1991-2000; and period 2 (P2), 2001-2010. Univariate and multivariate analyses using the Cox proportional hazards model were performed to determine prognostic factors associated with long-term survival. Survival was evaluated using Kaplan-Meier analyses. A total of 179 pancreatectomies were performed during P1 and 310 during P2. Perioperative mortality was 6.7 % (12/179) in P1 and 1.6 % (5/310) in P2 (p = 0.003). P2 had a greater number of lymph nodes resected (17 [0-50] vs. 7 [0-31]; p P2 (p P2 (p < 0.001). Factors associated with improved long-term survival remain comparable over time. Short- and long-term survival for patients with resected PDAC has improved over time due to decreased perioperative mortality and increased use of adjuvant therapy, although the proportion of 5-year survivors remains small.

Limit Cycles and Chaos via Quasi-periodicity in Two Coupled Ensembles of Ultra-cold Atoms.

Science.gov (United States)

Patra, Aniket; Yuzbashyan, Emil; Altshuler, Boris

We study the dynamics of two mesoscopic ensembles of ultra-cold two level atoms, which are collectively coupled to an optical cavity and are being pumped incoherently to the excited state. Whereas the time independent steady states are well understood, little is known about the time dependent ones. We explore and categorize various time dependent steady states, e.g. limit cycles and chaotic behavior. We draw a non-equilibrium phase diagram indicating different steady-state behaviors in different parts of the parameter space. We discuss the synchronization of the two ensembles in the time dependent steady states. We also show the onset of chaos via quasi-periodicity. The rich time dependent steady-state behavior, especially the existence of chaos, opens up possibilities for several engineering applications. Supported in part by the University and Louis Bevier Graduate Fellowship.

Modular invariance, universality and crossover in the quantum Hall effect

International Nuclear Information System (INIS)

Dolan, Brian P.

1999-01-01

An analytic form for the conductivity tensor in crossover between two quantum Hall plateaux is derived, which appears to be in good agreement with existing experimental data. The derivation relies on an assumed symmetry between quantum Hall states, a generalisation of the law of corresponding states from rational filling factors to complex conductivity, which has a mathematical expression in terms of an action of the modular group on the upper-half complex conductivity plane. This symmetry implies universality in quantum Hall crossovers. The assumption that the β-function for the complex conductivity is a complex analytic function, together with some experimental constraints, results in an analytic expression for the crossover, as a function of the external magnetic field

Tongues of periodicity in a family of two-dimensional discontinuous maps of real Moebius type

International Nuclear Information System (INIS)

Sushko, Iryna; Gardini, Laura; Puu, Toenu

2004-01-01

In this paper we consider a two-dimensional piecewise-smooth discontinuous map representing the so-called 'relative dynamics' of an Hicksian business cycle model. The main features of the dynamics occur in the parameter region in which no fixed points at finite distance exist, but we may have attracting cycles of any periods. The bifurcations associated with the periodicity tongues of the map are studied making use of the first-return map on a suitable segment of the phase plane. The bifurcation curves bounding the periodicity tongues in the parameter plane are related with saddle-node and border-collision bifurcations of the first-return map. Moreover, the particular 'sausages structure' of the bifurcation tongues is also explained

Simultaneous Two-Way Clustering of Multiple Correspondence Analysis

Science.gov (United States)

Hwang, Heungsun; Dillon, William R.

2010-01-01

A 2-way clustering approach to multiple correspondence analysis is proposed to account for cluster-level heterogeneity of both respondents and variable categories in multivariate categorical data. Specifically, in the proposed method, multiple correspondence analysis is combined with k-means in a unified framework in which "k"-means is…

Targeted energy transfers and passive acoustic wave redirection in a two-dimensional granular network under periodic excitation

Energy Technology Data Exchange (ETDEWEB)

Zhang, Yijing, E-mail: yzhng123@illinois.edu; Moore, Keegan J.; Vakakis, Alexander F. [Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 (United States); McFarland, D. Michael [Department of Aerospace Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 (United States)

2015-12-21

We study passive pulse redirection and nonlinear targeted energy transfer in a granular network composed of two semi-infinite, ordered homogeneous granular chains mounted on linear elastic foundations and coupled by weak linear stiffnesses. Periodic excitation in the form of repetitive half-sine pulses is applied to one of the chains, designated as the “excited chain,” whereas the other chain is initially at rest and is regarded as the “absorbing chain.” We show that passive pulse redirection and targeted energy transfer from the excited to the absorbing chain can be achieved by macro-scale realization of the spatial analog of the Landau-Zener quantum tunneling effect. This is realized by finite stratification of the elastic foundation of the excited chain and depends on the system parameters (e.g., the percentage of stratification) and on the parameters of the periodic excitation. Utilizing empirical mode decomposition and numerical Hilbert transforms, we detect the existence of two distinct nonlinear phenomena in the periodically forced network; namely, (i) energy localization in the absorbing chain due to sustained 1:1 resonance capture leading to irreversible pulse redirection from the excited chain, and (ii) continuous energy exchanges in the form of nonlinear beats between the two chains in the absence of resonance capture. Our results extend previous findings of transient passive energy redirection in impulsively excited granular networks and demonstrate that steady state passive pulse redirection in these networks can be robustly achieved under periodic excitation.

Hamiltonian bifurcation perspective on two interacting vortex pairs: From symmetric to asymmetric leapfrogging, period doubling, and chaos

Science.gov (United States)

Whitchurch, Brandon; Kevrekidis, Panayotis G.; Koukouloyannis, Vassilis

2018-01-01

In this work we study the dynamical behavior of two interacting vortex pairs, each one of them consisting of two point vortices with opposite circulation in the two-dimensional plane. The vortices are considered as effective particles and their interaction can be described in classical mechanics terms. We first construct a Poincaré section, for a typical value of the energy, in order to acquire a picture of the structure of the phase space of the system. We divide the phase space in different regions which correspond to qualitatively distinct motions and we demonstrate its different temporal evolution in the "real" vortex space. Our main emphasis is on the leapfrogging periodic orbit, around which we identify a region that we term the "leapfrogging envelope" which involves mostly regular motions, such as higher order periodic and quasiperiodic solutions. We also identify the chaotic region of the phase plane surrounding the leapfrogging envelope as well as the so-called walkabout and braiding motions. Varying the energy as our control parameter, we construct a bifurcation tree of the main leapfrogging solution and its instabilities, as well as the instabilities of its daughter branches. We identify the symmetry-breaking instability of the leapfrogging solution (in line with earlier works), and also obtain the corresponding asymmetric branches of periodic solutions. We then characterize their own instabilities (including period doubling ones) and bifurcations in an effort to provide a more systematic perspective towards the types of motions available to this dynamical system.

Interference-mediated synaptonemal complex formation with embedded crossover designation

Science.gov (United States)

Zhang, Liangran; Espagne, Eric; de Muyt, Arnaud; Zickler, Denise; Kleckner, Nancy E.

2014-01-01

Biological systems exhibit complex patterns at length scales ranging from the molecular to the organismic. Along chromosomes, events often occur stochastically at different positions in different nuclei but nonetheless tend to be relatively evenly spaced. Examples include replication origin firings, formation of chromatin loops along chromosome axes and, during meiosis, localization of crossover recombination sites (“crossover interference”). We present evidence in the fungus Sordaria macrospora that crossover interference is part of a broader pattern that includes synaptonemal complex (SC) nucleation. This pattern comprises relatively evenly spaced SC nucleation sites, among which a subset are crossover sites that show a classical interference distribution. This pattern ensures that SC forms regularly along the entire length of the chromosome as required for the maintenance of homolog pairing while concomitantly having crossover interactions locally embedded within the SC structure as required for both DNA recombination and structural events of chiasma formation. This pattern can be explained by a threshold-based designation and spreading interference process. This model can be generalized to give diverse types of related and/or partially overlapping patterns, in two or more dimensions, for any type of object. PMID:25380597

Exploring Associations among Writing Self-Perceptions, Writing Abilities, and Native Language of English-Spanish Two-Way Immersion Students

Science.gov (United States)

Neugebauer, Sabina R.; Howard, Elizabeth R.

2015-01-01

The current study, with 409 fourth graders in two-way immersion programs, explored the writing self-perceptions of native English and native Spanish speakers and the relationship between self-perceptions and writing performance. An adapted version of the Writer Self-Perception Scale (WSPS) was administered along with a writing task. Native English…

Bioequivalence study of two losartan tablet formulations with special emphasis on cardiac safety.

Science.gov (United States)

Khandave, Suhas S; Sawant, Satish V; Sahane, Rakhi V; Murthi, Vivekanand; Dhanure, Shivanand S; Surve, Pradeep G

2012-05-01

To study the bioequivalence of Losartan Potassium Tablets 50 mg manufactured by Micro Labs Ltd. India to Cozaar® Tablets 50 mg, manufactured by Merck Sharp and Dohme Ltd., UK in normal healthy adult subjects under fasting condition along with the comparative safety evaluation of both treatments. The in vitro dissolution studies were carried out on 12 units each of test and reference products using the paddle method and dissolution media like water, 0.1 N hydrochloric acid with pH 1.2, pH 4.5 acetate buffer and pH 6.8 phosphate buffer. An open label, randomized, two-treatment, two-period, two-sequence, crossover bioequivalence study with a washout period of 7 days was conducted in 60 healthy Indian male subjects. Serial blood samples were collected after drug administration in each study period. Plasma concentrations of losartan and losartan acid were determined using a validated LC-MS-MS method. The pharmacokinetic parameters of losartan and losartan acid were determined using a non compartmental model. Occurrence of adverse events, change in systolic blood pressure, diastolic blood pressure, heart rate and QT interval from the baseline to 3.50 h post dose were studied and compared between the two treatments as safety parameters. The in vitro study proved the essential similarity of both the formulations as evident from the similarity factor of > 50% in all the dissolution media. The ratios for geometric least square means and 90% confidence intervals were within the acceptance criteria of 80% to 125% for log transformed C(max), AUC(0-t) and AUC(0-∞) for losartan. No statistically significant difference between the two treatments was observed for either of the safety parameters. The test product Losartan Potassium tablets 50 mg manufactured by Micro Labs Limited, India was bioequivalent to Cozaar® tablets 50 mg, manufactured by Merck Sharp and Dohme Ltd., UK in terms of rate and extent of absorption. Both treatments were well tolerated and had similar non

Pondering Motivational Ups and Downs throughout a Two-Month Period: A Complex Dynamic System Perspective

Science.gov (United States)

Lasagabaster, David

2017-01-01

This paper describes a two-month longitudinal study in which five secondary education students learning English as a foreign language at school will be interviewed in order to analyse how their motivation varies during this period and what variables affect their motivational changes. The emphasis will thus be on motivation's dynamicity and…

Improve the open-circuit voltage of ZnO solar cells with inserting ZnS layers by two ways

International Nuclear Information System (INIS)

Sun, Yunfei; Yang, Jinghai; Yang, Lili; Cao, Jian; Gao, Ming; Zhang, Zhiqiang; Wang, Zhe; Song, Hang

2013-01-01

ZnS NPs layers were deposited on ZnO NRs by two different ways. One is spin coating; the other is successive ionic layer adsorption and reaction (SILAR) method. The ZnO NRs/ZnS NPs composites were verified by X-ray diffraction, X-ray photoelectron spectroscopy, and UV–visible spectrophotometer; their morphologies and thicknesses were examined by scanning electron microscopic and transmission electron microscopic images. The CdS quantum dot sensitized solar cells (QDSSCs) were constructed using ZnO NRs/ZnS NPs composites as photoanode and their photovoltaic characteristic was studied by J–V curves. The results indicated that the way of SILAR is more beneficial for retarding the back transfer of electrons to CdS and electrolyte than spin coating method. The open-circuit voltage increased to 0.59 V by introducing a ZnS layer through SILAR method. When ZnS NPs layer was deposited for 10 times on ZnO NRs, the conversion efficiency of QDSSC shows ∼3.3 folds increments of as-synthesized ZnO solar cell. - Graphical abstract: When ZnO nanorods were deposited by ZnS for 10 times, the conversion efficiency of QDSSC shows ∼3.3 folds increments of as-synthesized ZnO solar cell. Highlights: ► ZnS layers were deposited with two different ways. ► The way of SILAR is more beneficial for retarding the back transfer of electrons. ► The open-circuit voltage increased to 0.59 V by introducing a ZnS layer through SILAR method

Improve the open-circuit voltage of ZnO solar cells with inserting ZnS layers by two ways

Energy Technology Data Exchange (ETDEWEB)

Sun, Yunfei [State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033 (China); Graduate School of the Chinese Academy of Sciences, Beijing 100049 (China); Yang, Jinghai, E-mail: jhyang1@jlnu.edu.cn [Institute of Condensed State Physics, Jilin Normal University, Siping 136000 (China); Yang, Lili; Cao, Jian [Institute of Condensed State Physics, Jilin Normal University, Siping 136000 (China); Gao, Ming [State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033 (China); Graduate School of the Chinese Academy of Sciences, Beijing 100049 (China); Institute of Condensed State Physics, Jilin Normal University, Siping 136000 (China); Zhang, Zhiqiang; Wang, Zhe [Institute of Condensed State Physics, Jilin Normal University, Siping 136000 (China); Song, Hang [State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033 (China)

2013-04-15

ZnS NPs layers were deposited on ZnO NRs by two different ways. One is spin coating; the other is successive ionic layer adsorption and reaction (SILAR) method. The ZnO NRs/ZnS NPs composites were verified by X-ray diffraction, X-ray photoelectron spectroscopy, and UV–visible spectrophotometer; their morphologies and thicknesses were examined by scanning electron microscopic and transmission electron microscopic images. The CdS quantum dot sensitized solar cells (QDSSCs) were constructed using ZnO NRs/ZnS NPs composites as photoanode and their photovoltaic characteristic was studied by J–V curves. The results indicated that the way of SILAR is more beneficial for retarding the back transfer of electrons to CdS and electrolyte than spin coating method. The open-circuit voltage increased to 0.59 V by introducing a ZnS layer through SILAR method. When ZnS NPs layer was deposited for 10 times on ZnO NRs, the conversion efficiency of QDSSC shows ∼3.3 folds increments of as-synthesized ZnO solar cell. - Graphical abstract: When ZnO nanorods were deposited by ZnS for 10 times, the conversion efficiency of QDSSC shows ∼3.3 folds increments of as-synthesized ZnO solar cell. Highlights: ► ZnS layers were deposited with two different ways. ► The way of SILAR is more beneficial for retarding the back transfer of electrons. ► The open-circuit voltage increased to 0.59 V by introducing a ZnS layer through SILAR method.

Coherent transport in a system of periodic linear chain of quantum dots situated between two parallel quantum wires

International Nuclear Information System (INIS)

Petrosyan, Lyudvig S

2016-01-01

We study coherent transport in a system of periodic linear chain of quantum dots situated between two parallel quantum wires. We show that the resonant-tunneling conductance between the wires exhibits a Rabi splitting of the resonance peak as a function of Fermi energy in the wires. This effect is an electron transport analogue of the Rabi splitting in optical spectra of two interacting systems. The conductance peak splitting originates from the anticrossing of Bloch bands in a periodic system that is caused by a strong coupling between the electron states in the quantum dot chain and quantum wires. (paper)

Risk of injury after alcohol consumption from case-crossover studies in five countries from the America’s

Science.gov (United States)

Borges, Guilherme; Orozco, Ricardo; Monteiro, Maristela; Cherpitel, Cheryl; Then, Eddy Pérez; López, Víctor A.; Bassier-Paltoo, Marcia; Weil A., Donald; de Bradshaw, Aldacira M

2012-01-01

Aims This study aimed to: 1) provide relative risk (RR) estimates between acute alcohol use and injuries from emergency departments in the Dominican Republic, Guatemala, Guyana, Nicaragua and Panama, and 2) test whether the RR differs if two control periods for the estimates were used. Design Case-crossover methodology was used to obtain estimates of the RR of having an injury within six hours after drinking alcohol, using a pair-matching design with control periods of the same time of day the day prior to injury, and the same time of day and day of week the week prior to injury. Setting Emergency departments(EDs). Participants 2,503 injured patients from EDs were interviewed between 2010–2011, with a response rate of 92.6%. Measurements Number of drinks consumed within six hours prior to the injury and in the two control periods. Findings The RR of injury after drinking alcohol was 4.38 (95% confidence interval CI= 3.29–5.84) using as the control period the prior week, and 5.35 (CI=3.50–8.17) using as a control period the prior day. The RR was 5.08 (CI=4.15–6.23) in multiple matching. Those drinking 1–2 drinks had a RR of 4.85 (CI=3.12–7.54); those drinking 3–5 a RR of 5.00 (CI =3.47–7.18); those drinking 6–15 a RR of 4.54 (CI=3.36–6.14); and those drinking 16 or more a RR of 10.42 (CI=4.38–24.79). Conclusions As in other countries, alcohol drinking is a trigger for an injury in all five countries. The use of more than one control period give further strength to these findings from case-crossover analysis. PMID:22775508

Effective Two-way Communication of Environmental Hazards: Understanding Public Perception in the UK

Science.gov (United States)

Lorono-Leturiondo, Maria; O'Hare, Paul; Cook, Simon; Hoon, Stephen R.; Illingworth, Sam

2017-04-01

Climate change intensified hazards, such as floods and landslides, require exploring renewed ways of protecting at-risk communities (World Economic Forum 2016). Scientists are being encouraged to explore new pathways to work closely with affected communities in search of experiential knowledge that is able to complement and extend scientific knowledge (see for instance Whatmore and Landström 2011 and Höpner et al. 2010). Effective two-way communication of environmental hazards is, however, a challenge. Besides considering factors such as the purpose of communication, or the characteristics of the different formats; effective communication has to carefully acknowledge the personal framework of the individuals involved. Existing experiences, values, beliefs, and needs are critical determinants of the way they perceive and relate to these hazards, and in turn, of the communication process in which they are involved (Longnecker 2016 and Gibson et al. 2016). Our study builds on the need to analyze how the public perceives environmental hazards in order to establish forms of communication that work. Here we present early findings of a survey analysing the UK public's perception and outline how survey results can guide more effective two-way communication practices between scientists and affected communities. We explore the perception of environmental hazards in terms of how informed and concerned the public is, as well as how much ownership they claim over these phenomena. In order to gain a more accurate image, we study environmental hazards in relation to other risks threatening the UK, such as large-scale involuntary migration or unemployment (World Economic Forum 2016, Bord et al. 1998). We also explore information consumption in relation to environmental hazards and the public's involvement in advancing knowledge. All these questions are accompanied by an extensive demographics section that allows us to ascertain how the context or environment in which an

Precoder Design and Power Allocation for MIMO Cognitive Radio Two-Way Relaying Systems

KAUST Repository

Sboui, Lokman

2016-08-11

In this paper, we study a multiple-antenna two-way relaying (TWR) cognitive radio (CR) system. A space alignment (SA) technique is adopted by the secondary users (SUs) to avoid interference with the primary users (PUs). We derive the optimal power allocation that maximizes the TWR achievable SU sum- rate while respecting the total power budget and the relay power constraints. We also analyze the case in which the relay is able to optimize its gain matrix structure to enhance the SU sum-rate. In the numerical results, we quantify the sum-rate gain of using the SA in the TWR CR and we show that the SU sum-rate is very limited when the relay power is low or the PU power and its resulting interference are high. In addition, we optimize the relay gain using an iterative algorithm and compare between different relay matrix structures.

Two ways to handle a pension plan surplus.

Science.gov (United States)

Beautyman, M J

1991-01-01

A healthcare organization wanting to tap into its pension plan surplus may be reluctant to do so for fear of Medicare recapture. By following a recent court decision and a reasonable interpretation of Medicare regulations, however, a facility may terminate an existing pension plan, purchase a group annuity contract, and reduce Medicare recapture. Two methods for treating termination of a plan are in line with Medicare rules. A facility considering termination should analyze the effects of both and use the method likely to produce a better financial result.

A condition-based maintenance policy with non-periodic inspections for a two-unit series system

International Nuclear Information System (INIS)

Castanier, B.; Grall, A.; Berenguer, C.

2005-01-01

This paper considers a condition-based maintenance policy for a two-unit deteriorating system. Each unit is subject to gradual deterioration and is monitored by sequential non-periodic inspections. It can be maintained by good as new preventive or corrective replacements. Every inspection or replacement entails a set-up cost and a component-specific unit cost but if actions on the two components are combined, the set-up cost is charged only once. A parametric maintenance decision framework is proposed to coordinate inspection/replacement of the two components and minimize the long-run maintenance cost of the system. A stochastic model is developed on the basis of the semi-regenerative properties of the maintained system state and the associated cost model is used to assess and optimize the performance of the maintenance model. Numerical experiments emphasize the interest of a control of the operation groupings

Transport behavior and rice uptake of radiostrontium and radiocesium in flooded paddy soils contaminated in two contrasting ways

International Nuclear Information System (INIS)

Choi, Yong-Ho; Lim, Kwang-Muk; Jun, In; Keum, Dong-Kwon; Han, Moon-Hee; Kim, In-Gyu

2011-01-01

In order to investigate the transport behavior and rice uptake of radiostrontium and radiocesium in flooded rice fields, lysimeter experiments with two paddy soils were performed in a greenhouse. A solution containing 85 Sr and 137 Cs was applied in two different ways — being mixed with the top soil 27 d before transplanting or being dropped to the surface water 1 d after transplanting. Rice uptake was quantified with two kinds of transfer factor — TF m (dimensionless) and TF a (m 2 kg −1 -dry) for the pre- and post-transplanting depositions, respectively. For brown rice, the TF m values of 85 Sr and 137 Cs differed between the soils by factors of 2 (1.6 × 10 −2 and 2.5 × 10 −2 ) and 7 (2.2 × 10 −2 and 1.5 × 10 −1 ), respectively. Corresponding factors by the TF a values were 2 (2.5 × 10 −4 and 4.4 × 10 −4 ) for 85 Sr and 3 (1.1 × 10 −3 and 2.9 × 10 −3 ) for 137 Cs. Straws had several times higher TF m and TF a values of 85 Sr than of 137 Cs. The surface-water concentrations were substantially higher for the TF a than for the TF m , indicating the possibility of a much higher plant-base uptake for the TF a . In the TF a soils, 137 Cs and, to a lesser degree, 85 Sr were severely localized towards the soil surface, probably leading to an increased root uptake. The activity loss due to plant uptake and water percolation was generally inconsiderable. Time-dependent K d values of 85 Sr measured in a parallel experiment ranged from 20 to 170, whereas 137 Cs had much higher K d values. The use of TF a values instead of TF m values turned out to be a reasonable approach to the evaluation of a vegetation-period deposition.

Periodic electromagnetic vacuum in the two-dimensional Yang-Mills theory with the Chern-Simons mass

International Nuclear Information System (INIS)

Skalozub, V.V.; Vilensky, S.A.; Zaslavsky, A.Yu.

1993-06-01

The periodic vacuum structure formed from magnetic and electric fields is derived in the two-dimensional Yang-Mills theory with the Chern-Simons term. It is shown that both the magnetic flux quantization in the fundamental sell and conductivity quantization inherent to the vacuum. Hence, the quantum Hall effect gets its natural explanation. (author). 10 refs

A Two-Study Examination of Work-Family Conflict, Production Deviance and Gender

Science.gov (United States)

Ferguson, Merideth; Carlson, Dawn; Hunter, Emily M.; Whitten, Dwayne

2012-01-01

Building on the spillover and crossover literatures of work-family conflict and the theoretical framework of Conservation of Resources Theory (Hobfoll, 1989) we examine the effects of conflict on production deviance. Using a two-study constructive replication and extension design, we examine how partner work-to-family conflict contributes to job…

The BCS-BEC crossover: From ultra-cold Fermi gases to nuclear systems

Science.gov (United States)

Strinati, Giancarlo Calvanese; Pieri, Pierbiagio; Röpke, Gerd; Schuck, Peter; Urban, Michael

2018-04-01

This report addresses topics and questions of common interest in the fields of ultra-cold gases and nuclear physics in the context of the BCS-BEC crossover. By this crossover, the phenomena of Bardeen-Cooper-Schrieffer (BCS) superfluidity and Bose-Einstein condensation (BEC), which share the same kind of spontaneous symmetry breaking, are smoothly connected through the progressive reduction of the size of the fermion pairs involved as the fundamental entities in both phenomena. This size ranges, from large values when Cooper pairs are strongly overlapping in the BCS limit of a weak inter-particle attraction, to small values when composite bosons are non-overlapping in the BEC limit of a strong inter-particle attraction, across the intermediate unitarity limit where the size of the pairs is comparable with the average inter-particle distance. The BCS-BEC crossover has recently been realized experimentally, and essentially in all of its aspects, with ultra-cold Fermi gases. This realization, in turn, has raised the interest of the nuclear physics community in the crossover problem, since it represents an unprecedented tool to test fundamental and unanswered questions of nuclear many-body theory. Here, we focus on the several aspects of the BCS-BEC crossover, which are of broad joint interest to both ultra-cold Fermi gases and nuclear matter, and which will likely help to solve in the future some open problems in nuclear physics (concerning, for instance, neutron stars). Similarities and differences occurring in ultra-cold Fermi gases and nuclear matter will then be emphasized, not only about the relative phenomenologies but also about the theoretical approaches to be used in the two contexts. Common to both contexts is the fact that at zero temperature the BCS-BEC crossover can be described at the mean-field level with reasonable accuracy. At finite temperature, on the other hand, inclusion of pairing fluctuations beyond mean field represents an essential ingredient

EVALUATION OF MICROLEAKAGE DEGREE IN COMPOSITE RESIN RESTORATIONS BY COMPARING TWO ADHESIVES SYSTEMS AFTER DIFFERENT AGING PERIODS

OpenAIRE

Falconí-Borja, Gabriela Marina; Molina-Pule, Carla Grimaneza; Velásquez-Ron, Byron Vinicio; Armas-Vega, Ana del Carmen

2016-01-01

ABSTRACT Introduction: the clinical success of adhesive systems is based on the use of a responsible for creating microporosity in the dental structure acid and arises assess in vitro the degree of microfiltration in direct restorations with cavities class V where two adhesive systems differently used composition and at different periods of time. Methods: in the cervical third of 60 third molars extracted by therapeutic indication performed by diamond instruments, two cavities one on the ...

Advanced transportation system study: Manned launch vehicle concepts for two way transportation system payloads to LEO

Science.gov (United States)

Duffy, James B.

1993-01-01

The purpose of the Advanced Transportation System Study (ATSS) task area 1 study effort is to examine manned launch vehicle booster concepts and two-way cargo transfer and return vehicle concepts to determine which of the many proposed concepts best meets NASA's needs for two-way transportation to low earth orbit. The study identified specific configurations of the normally unmanned, expendable launch vehicles (such as the National Launch System family) necessary to fly manned payloads. These launch vehicle configurations were then analyzed to determine the integrated booster/spacecraft performance, operations, reliability, and cost characteristics for the payload delivery and return mission. Design impacts to the expendable launch vehicles which would be required to perform the manned payload delivery mission were also identified. These impacts included the implications of applying NASA's man-rating requirements, as well as any mission or payload unique impacts. The booster concepts evaluated included the National Launch System (NLS) family of expendable vehicles and several variations of the NLS reference configurations to deliver larger manned payload concepts (such as the crew logistics vehicle (CLV) proposed by NASA JSC). Advanced, clean sheet concepts such as an F-1A engine derived liquid rocket booster (LRB), the single stage to orbit rocket, and a NASP-derived aerospace plane were also included in the study effort. Existing expendable launch vehicles such as the Titan 4, Ariane 5, Energia, and Proton were also examined. Although several manned payload concepts were considered in the analyses, the reference manned payload was the NASA Langley Research Center's HL-20 version of the personnel launch system (PLS). A scaled up version of the PLS for combined crew/cargo delivery capability, the HL-42 configuration, was also included in the analyses of cargo transfer and return vehicle (CTRV) booster concepts. In addition to strictly manned payloads, two-way cargo

Two period measures for comparing the fertility of marriage and cohabitation

Directory of Open Access Journals (Sweden)

Benoît Laplante

2015-02-01

Full Text Available Background: The diffusion of cohabitation and, presumably, of childbearing within cohabitation, inspires interest in measuring the respective contribution of childbearing within marriage and within cohabitation to overall fertility. However, there is no consensus on a proper way to do so. Objective: Contribute to the development of tools for assessing the relative importance of marriage and cohabitation to overall fertility by developing period measures closely related to age-specific fertility rates and the total fertility rate. Methods: We introduce two measures: 1 the contribution of the conjugal state (living alone, living in a cohabiting union, being married to age-specific fertility rates (CASFR and 2 the contribution of the conjugal state to the TFR (CTFR. These measures are similar in construction to the marital (legitimate fertility rates and marital (legitimate TFR, but they are weighted by the proportion of women living alone, cohabiting, or being married at each age, so that their sum is the overall TFR. Taken together, they represent the fertility of the average woman of a synthetic cohort who moves across the various conjugal states (living alone, cohabiting, being married over her life course. They provide "realistic" estimates of completed fertility within each conjugal state. Conclusions: CASFRs provide a description of the fertility, over her life course, of a synthetic woman who would have spent her reproductive years living alone, cohabiting, and being married as the average woman of the synthetic cohort. CTFR provides a decomposition of the cumulative fertility of this synthetic woman. Over her life course, she would have had exactly the number of children computed using the overall TFR, but CTFR details the proportion of these children she would have had while living alone, while cohabiting, and while being married. Comments: Despite being defined as a conditional ASR weighted by the age-specific proportion of women living

High-pressure water electrolysis: Electrochemical mitigation of product gas crossover

International Nuclear Information System (INIS)

Schalenbach, Maximilian; Stolten, Detlef

2015-01-01

Highlights: • New technique to reduce gas crossover during water electrolysis • Increase of the efficiency of pressurized water electrolysis • Prevention of safety hazards due to explosive gas mixtures caused by crossover • Experimental realization for a polymer electrolyte membrane electrolyzer • Discussion of electrochemical crossover mitigation for alkaline water electrolysis - Abstract: Hydrogen produced by water electrolysis can be used as an energy carrier storing electricity generated from renewables. During water electrolysis hydrogen can be evolved under pressure at isothermal conditions, enabling highly efficient compression. However, the permeation of hydrogen through the electrolyte increases with operating pressure and leads to efficiency loss and safety hazards. In this study, we report on an innovative concept, where the hydrogen crossover is electrochemically mitigated by an additional electrode between the anode and the cathode of the electrolysis cell. Experimentally, the technique was applied to a proton exchange membrane water electrolyzer operated at a hydrogen pressure that was fifty times larger than the oxygen pressure. Therewith, the hydrogen crossover was reduced and the current efficiency during partial load operation was increased. The concept is also discussed for water electrolysis that is operated at balanced pressures, where the crossover of hydrogen and oxygen is mitigated using two additional electrodes

Two-fluid hydrodynamic modes in a trapped superfluid gas

International Nuclear Information System (INIS)

Taylor, E.; Griffin, A.

2005-01-01

In the collisional region at finite temperatures, the collective modes of superfluids are described by the Landau two-fluid hydrodynamic equations. This region can now be probed over the entire BCS-Bose-Einstein-condensate crossover in trapped Fermi superfluids with a Feshbach resonance, including the unitarity region. Building on the approach initiated by Zaremba, Nikuni, and Griffin in 1999 for trapped atomic Bose gases, we present a variational formulation of two-fluid hydrodynamic collective modes based on the work of Zilsel in 1950 developed for superfluid helium. Assuming a simple variational Ansatz for the superfluid and normal fluid velocities, the frequencies of the hydrodynamic modes are given by solutions of coupled algebraic equations, with constants only involving spatial integrals over various equilibrium thermodynamic derivatives. This variational approach is both simpler and more physical than a direct attempt to solve the Landau two-fluid differential equations. Our two-fluid results are shown to reduce to those of Pitaevskii and Stringari for a pure superfluid at T=0

Return Period of a Sea Storm with at Least Two Waves Higher than a Fixed Threshold

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Felice Arena

2013-01-01

Full Text Available Practical applications in ocean engineering require the long-term analysis for prediction of extreme waves, that identify design conditions. If extreme individual waves are investigated, we need to combine long-term statistical analysis of ocean waves with short-term statistics. The former considers the distribution of standard deviation of free surface displacement in the considered location in a long-time span, of order of 10 years or more. The latter analyzes the distribution of individual wave heights in a sea state, which is a Gaussian process in time domain. Recent advanced approaches enable the combination of the two analyses. In the paper the analytical solution is obtained for the return period of a sea storm with at least two individual waves higher than a fixed level. This solution is based on the application of the Equivalent Triangular Storm model for the representation of actual storms. One of the corollaries of the solution gives the exact expression for the probability that at least two waves higher than fixed level are produced during the lifetime of a structure. The previous solution of return period and the relative probability of exceedance may be effectively applied for the risk analysis of ocean structures.

Quantum phase crossovers with finite atom number in the Dicke model

International Nuclear Information System (INIS)

Hirsch, J G; Castaños, O; Nahmad-Achar, E; López-Peña, R

2013-01-01

Two-level atoms interacting with a one-mode cavity field at zero temperature have order parameters which reflect the presence of a quantum phase transition at a critical value of the atom–cavity coupling strength. Two popular examples are the number of photons inside the cavity and the number of excited atoms. Coherent states provide a mean field description, which becomes exact in the thermodynamic limit. Employing symmetry-adapted (SA) SU(2) coherent states the quantum crossover, precursor of the critical behavior, can be described for a finite number of atoms. A variation after projection treatment, involving a numerical minimization of the SA energy surface, associates the quantum crossover with a discontinuity in the order parameters, which originates from competition between two local minima in the SA energy surface. Although this discontinuity is not present in finite systems, it provides a good description of 1/N effects in the observables. (paper)

Single-crossover recombination in discrete time.

Science.gov (United States)

von Wangenheim, Ute; Baake, Ellen; Baake, Michael

2010-05-01

Modelling the process of recombination leads to a large coupled nonlinear dynamical system. Here, we consider a particular case of recombination in discrete time, allowing only for single crossovers. While the analogous dynamics in continuous time admits a closed solution (Baake and Baake in Can J Math 55:3-41, 2003), this no longer works for discrete time. A more general model (i.e. without the restriction to single crossovers) has been studied before (Bennett in Ann Hum Genet 18:311-317, 1954; Dawson in Theor Popul Biol 58:1-20, 2000; Linear Algebra Appl 348:115-137, 2002) and was solved algorithmically by means of Haldane linearisation. Using the special formalism introduced by Baake and Baake (Can J Math 55:3-41, 2003), we obtain further insight into the single-crossover dynamics and the particular difficulties that arise in discrete time. We then transform the equations to a solvable system in a two-step procedure: linearisation followed by diagonalisation. Still, the coefficients of the second step must be determined in a recursive manner, but once this is done for a given system, they allow for an explicit solution valid for all times.

Ser derivation and power optimization of a two-way multirelay cooperative communication system

International Nuclear Information System (INIS)

Rehman, S.U.; Shah, S.I.; Fareed, M.M.

2014-01-01

In this paper, we consider Rayleigh fading based cooperative communication system with AaF (Amplify and Forward) relaying using multiple relays. We take spectrally efficient two-way model of cooperative communication terminals and formulate performance evaluation framework in terms of SER (Symbol Error Rate). We not only consider fading channel for this performance evaluation but also consider the effect of relay terminal location into our model which does not require any CSI (Channel State Information) at transmitting nodes. We have proposed power allocation framework for these nodes and analytically derived SER performance results. We have numerically evaluated this framework for power optimization as well as minimizing required SER. Significant performance improvement as compared with equal power sharing among the cooperating terminals is achieved using our proposed framework. It is shown that virtual cooperative antenna configurations is able to demonstrate up to 3dB gain as compared with co-located antenna configurations. Thus incorporating relay location information for performance evaluation results significant power savings. (author)

Sparse Channel Estimation for MIMO-OFDM Two-Way Relay Network with Compressed Sensing

Directory of Open Access Journals (Sweden)

Aihua Zhang

2013-01-01

Full Text Available Accurate channel impulse response (CIR is required for equalization and can help improve communication service quality in next-generation wireless communication systems. An example of an advanced system is amplify-and-forward multiple-input multiple-output two-way relay network, which is modulated by orthogonal frequency-division multiplexing. Linear channel estimation methods, for example, least squares and expectation conditional maximization, have been proposed previously for the system. However, these methods do not take advantage of channel sparsity, and they decrease estimation performance. We propose a sparse channel estimation scheme, which is different from linear methods, at end users under the relay channel to enable us to exploit sparsity. First, we formulate the sparse channel estimation problem as a compressed sensing problem by using sparse decomposition theory. Second, the CIR is reconstructed by CoSaMP and OMP algorithms. Finally, computer simulations are conducted to confirm the superiority of the proposed methods over traditional linear channel estimation methods.

Figure-ground segregation requires two distinct periods of activity in V1: a transcranial magnetic stimulation study.

Science.gov (United States)

Heinen, Klaartje; Jolij, Jacob; Lamme, Victor A F

2005-09-08

Discriminating objects from their surroundings by the visual system is known as figure-ground segregation. This process entails two different subprocesses: boundary detection and subsequent surface segregation or 'filling in'. In this study, we used transcranial magnetic stimulation to test the hypothesis that temporally distinct processes in V1 and related early visual areas such as V2 or V3 are causally related to the process of figure-ground segregation. Our results indicate that correct discrimination between two visual stimuli, which relies on figure-ground segregation, requires two separate periods of information processing in the early visual cortex: one around 130-160 ms and the other around 250-280 ms.

On the large-scale structure and spectral dynamics of two-dimensional turbulence in a periodic channel

NARCIS (Netherlands)

Kramer, W.; Clercx, H.J.H.; van Heijst, G.J.F.

2008-01-01

This paper reports on a numerical study of forced two-dimensional turbulence in a periodic channel with flat no-slip walls. Since corners or curved domain boundaries, which are met in the standard rectangular, square, or circular geometries, are absent in this geometry, the (statistical) analysis of

On the large-scale structure and spectral dynamics of two-dimensional turbulence in a periodic channel

NARCIS (Netherlands)

Kramer, W.; Clercx, H.J.H.; Heijst, van G.J.F.

2008-01-01

This paper reports on a numerical study of forced two-dimensional turbulence in a periodic channel with flat no-slip walls. Since corners or curved domain boundaries, met in the standard rectangular, square or circular geometries, are absent in this geometry, the (statistical) analysis of the flow

Effects of regularly consuming dietary fibre rich soluble cocoa products on bowel habits in healthy subjects: a free-living, two-stage, randomized, crossover, single-blind intervention

Directory of Open Access Journals (Sweden)

Sarriá Beatriz

2012-04-01

Full Text Available Abstract Background Dietary fibre is both preventive and therapeutic for bowel functional diseases. Soluble cocoa products are good sources of dietary fibre that may be supplemented with this dietary component. This study assessed the effects of regularly consuming two soluble cocoa products (A and B with different non-starch polysaccharides levels (NSP, 15.1 and 22.0% w/w, respectively on bowel habits using subjective intestinal function and symptom questionnaires, a daily diary and a faecal marker in healthy individuals. Methods A free-living, two-stage, randomized, crossover, single-blind intervention was carried out in 44 healthy men and women, between 18-55 y old, who had not taken dietary supplements, laxatives, or antibiotics six months before the start of the study. In the four-week-long intervention stages, separated by a three-week-wash-out stage, two servings of A and B, that provided 2.26 vs. 6.60 g/day of NSP respectively, were taken. In each stage, volunteers' diet was recorded using a 72-h food intake report. Results Regularly consuming cocoa A and B increased fibre intake, although only cocoa B significantly increased fibre intake (p Conclusions Regular consumption of the cocoa products increases dietary fibre intake to recommended levels and product B improves bowel habits. The use of both objective and subjective assessments to evaluate the effects of food on bowel habits is recommended.

Evaluation of marginal fit of two all-ceramic copings with two finish lines

Science.gov (United States)

Subasi, Gulce; Ozturk, Nilgun; Inan, Ozgur; Bozogullari, Nalan

2012-01-01

Objectives: This in-vitro study investigated the marginal fit of two all-ceramic copings with 2 finish line designs. Methods: Forty machined stainless steel molar die models with two different margin designs (chamfer and rounded shoulder) were prepared. A total of 40 standardized copings were fabricated and divided into 4 groups (n=10 for each finish line-coping material). Coping materials tested were IPS e.max Press and Zirkonzahn; luting agent was Variolink II. Marginal fit was evaluated after cementation with a stereomicroscope (Leica MZ16). Two-way analysis of variance and Tukey-HSD test were performed to assess the influence of each finish line design and ceramic type on the marginal fit of 2 all-ceramic copings (α =.05). Results: Two-way analysis of variance revealed no statistically significant differences for marginal fit relative to finish lines (P=.362) and ceramic types (P=.065). Conclusion: Within the limitations of this study, both types of all-ceramic copings demonstrated that the mean marginal fit was considered acceptable for clinical application (⩽120 μm). PMID:22509119

A genetic algorithm for multiple relay selection in two-way relaying cognitive radio networks

KAUST Repository

Alsharoa, Ahmad M.

2013-09-01

In this paper, we investigate a multiple relay selection scheme for two-way relaying cognitive radio networks where primary users and secondary users operate on the same frequency band. More specifically, cooperative relays using Amplifyand- Forward (AF) protocol are optimally selected to maximize the sum rate of the secondary users without degrading the Quality of Service (QoS) of the primary users by respecting a tolerated interference threshold. A strong optimization tool based on genetic algorithm is employed to solve our formulated optimization problem where discrete relay power levels are considered. Our simulation results show that the practical heuristic approach achieves almost the same performance of the optimal multiple relay selection scheme either with discrete or continuous power distributions. Copyright © 2013 by the Institute of Electrical and Electronic Engineers, Inc.

Application of two way indicator species analysis in lowland plant types classification.

Science.gov (United States)

Kooch, Yahya; Jalilvand, Hamid; Bahmanyar, Mohammad Ali; Pormajidian, Mohammad Reza

2008-03-01

A TWINSPAN classification of 60 sample plots from the Khanikan forest (North of Iran) is presented. Plant types were determined from field observations and sample plot data arranged and analyzed in association tables. The types were defined on the basis of species patterns of presence, absence and coverage values. Vegetation was sampled with randomized-systematic method. Vegetation data including density and cover percentage were estimated quantitatively within each quadrate and using the two-way indicator species analysis. The objectives of the study were to plant type's classification for Khanikan lowland forest in North of Iran, Identification of indicator species in plant types and increase our understanding in regarding to one of Multivariate analysis methods (TWINSPAN). Five plant types were produced for the study area by TWINSPAN, i.e., Menta aquatica, Oplismenus undulatifolius, Carex grioletia, Viola odarata and Rubus caesius. Therefore, at each step of the process, the program identifies indicator species that show strongly differential distributions between groups and so can severe to distinguish the groups. The final result, incorporating elements of classification can provide a compact and powerful summary of pattern in the data set.

Two-way actuation behavior of shape memory polymer/elastomer core/shell composites

International Nuclear Information System (INIS)

Kang, Tae-Hyung; Lee, Jeong-Min; Yu, Woong-Ryeol; Youk, Ji Ho; Ryu, Hee Wook

2012-01-01

Semi-crystalline shape memory polymers (SMPs) show net two-way shape memory (2W-SM) behavior under constant stresses by the recoverable creep strain upon heating and stress-induced crystallization under the application of creep stress upon cooling. The applied constant stress is the key factor in this 2W-SM behavior. A core/shell structure is manufactured for the purpose of imparting a constant stress upon SMPs. An SMP in film or fiber form is dipped into a solution of an elastomer, photoinitiator, and curing agent and then dried out. After this dip coating process is repeatedly carried out, the SMP/elastomer core/shell composite is deformed into a temporary shape after being heated up above the transition temperature of the SMP. Under constant strain conditions, the composite is cooled down, after which the shell elastomer is cured using ultraviolet light. Then, the SMP/elastomer core/shell composite extends and contracts upon cooling and heating, respectively, without any external load. This cyclic deformation behavior is characterized, demonstrating that the current method offers a simple macroscopic processing technique to manufacture 2W-SM polymer composites. (paper)

Two-Dimensional Homogeneous Fermi Gases

Science.gov (United States)

Hueck, Klaus; Luick, Niclas; Sobirey, Lennart; Siegl, Jonas; Lompe, Thomas; Moritz, Henning

2018-02-01

We report on the experimental realization of homogeneous two-dimensional (2D) Fermi gases trapped in a box potential. In contrast to harmonically trapped gases, these homogeneous 2D systems are ideally suited to probe local as well as nonlocal properties of strongly interacting many-body systems. As a first benchmark experiment, we use a local probe to measure the density of a noninteracting 2D Fermi gas as a function of the chemical potential and find excellent agreement with the corresponding equation of state. We then perform matter wave focusing to extract the momentum distribution of the system and directly observe Pauli blocking in a near unity occupation of momentum states. Finally, we measure the momentum distribution of an interacting homogeneous 2D gas in the crossover between attractively interacting fermions and bosonic dimers.

Fine mapping of shattering locus Br2 reveals a putative chromosomal inversion polymorphism between the two lineages of Aegilops tauschii.

Science.gov (United States)

Zhang, Zhengzhi; Zhu, Huilan; Gill, Bikram S; Li, Wanlong

2015-04-01

This work laid the foundation for cloning of shattering gene Br2 and provided first line of evidence that two major Aegilops tauschii lineages are differentiated by an inversion polymorphism. Chromosome inversions often accompany population differentiation and capture local adaptation during speciation. Aegilops tauschii, the D-genome donor species of hexaploid wheat, consists of two genetically isolated lineages, L1 and L2, but little is known about the genetic mechanisms underlying the population differentiation in this diploid species. During fine mapping of the shattering gene Br2 using a large F2 population derived from a cross between TA1604 (an L1 accession) and AL8/78 (an L2 accession), we found contrasting patterns of crossover distribution in the Br2 interval and neighboring regions despite the high local gene synteny with Brachypodium distachyon and rice. Br2 was localized in a 0.08-cM interval, and 13 marker loci formed a block, where single-crossovers were completely suppressed, but double-crossovers were enriched with a recombination rate of ~11 cM/Mb. In contrast, in a neighboring region no double-crossover was recovered, but single-crossover rate reached 24 cM/Mb, which is much higher than the genome-wide average. This result suggests a putative inversion polymorphism between the parental lines in the Br2 region. Genotyping using the markers from the Br2 region divided a collection of 55 randomly sampled A. tauschii accessions into two major groups, and they are largely genetically isolated. The two groups correspond to the L1 and L2 lineages based on their geographic distribution patterns. This provides first evidence that inversions may underlie the evolution of A. tauschii lineages. The presence of inter-lineage inversions may complicate map-based cloning in A. tauschii and transfer of useful traits to wheat.

Photomagnetic studies on spin-crossover solid solutions containing two different metal complexes, [Fe(1-bpp)(2)](x)[M(terpy)2](1-x)[BF4]2 (M = Ru or Co).

Science.gov (United States)

Chastanet, Guillaume; Tovee, Clare A; Hyett, Geoffrey; Halcrow, Malcolm A; Létard, Jean-François

2012-04-28

The photomagnetic properties of two series of spin-crossover solid solutions, [Fe(1-bpp)(2)](x)[Ru(terpy)(2)](1-x)(BF(4))(2) and [Fe(1-bpp)(2)](x)[Co(terpy)(2)](1-x)(BF(4))(2) (1-bpp = 2,6-bis[pyrazol-1-yl]pyridine), have been investigated. For all the materials, the evolution of the T(LIESST) value, the high-spin → low-spin relaxation parameters and the LITH loops were thoroughly studied. Interestingly in the Fe:Co series, along the photo-excitation, cobalt ions are concomitantly converted from low-spin to high-spin states with the iron centres, and also fully relax after light excitation. This journal is © The Royal Society of Chemistry 2012

Crossover between the Gaussian orthogonal ensemble, the Gaussian unitary ensemble, and Poissonian statistics.

Science.gov (United States)

Schweiner, Frank; Laturner, Jeanine; Main, Jörg; Wunner, Günter

2017-11-01

Until now only for specific crossovers between Poissonian statistics (P), the statistics of a Gaussian orthogonal ensemble (GOE), or the statistics of a Gaussian unitary ensemble (GUE) have analytical formulas for the level spacing distribution function been derived within random matrix theory. We investigate arbitrary crossovers in the triangle between all three statistics. To this aim we propose an according formula for the level spacing distribution function depending on two parameters. Comparing the behavior of our formula for the special cases of P→GUE, P→GOE, and GOE→GUE with the results from random matrix theory, we prove that these crossovers are described reasonably. Recent investigations by F. Schweiner et al. [Phys. Rev. E 95, 062205 (2017)2470-004510.1103/PhysRevE.95.062205] have shown that the Hamiltonian of magnetoexcitons in cubic semiconductors can exhibit all three statistics in dependence on the system parameters. Evaluating the numerical results for magnetoexcitons in dependence on the excitation energy and on a parameter connected with the cubic valence band structure and comparing the results with the formula proposed allows us to distinguish between regular and chaotic behavior as well as between existent or broken antiunitary symmetries. Increasing one of the two parameters, transitions between different crossovers, e.g., from the P→GOE to the P→GUE crossover, are observed and discussed.

Give me five! - reasons for two-way communication between experts and citizens in relation to air pollution risk

Science.gov (United States)

Loroño-Leturiondo, Maria; O'Hare, Paul; Cook, Simon; Hoon, Stephen R.; Illingworth, Sam

2018-04-01

Air pollution is a major environmental concern for many populations worldwide. Communication efforts so far have been based on a one-way provision of evidence and information from experts to society, and have arguably failed in their mission to foster a more aware and engaged society, or to result in cleaner air. Globally we are facing both an air quality crisis and a communication emergency. This paper focuses on the communication of air pollution risk, from the threats it poses (e.g. severe impacts to human health) to the opportunities it can create (e.g. behavioural or technological alternatives that lead to cleaner air). It supports the case for moving away from one-way communication, and identifies five key benefits of a practical two-way communication between experts and citizens in order to engender positive change and improve global air quality.

Typical Periods for Two-Stage Synthesis by Time-Series Aggregation with Bounded Error in Objective Function

Energy Technology Data Exchange (ETDEWEB)

Bahl, Björn; Söhler, Theo; Hennen, Maike; Bardow, André, E-mail: andre.bardow@ltt.rwth-aachen.de [Institute of Technical Thermodynamics, RWTH Aachen University, Aachen (Germany)

2018-01-08

Two-stage synthesis problems simultaneously consider here-and-now decisions (e.g., optimal investment) and wait-and-see decisions (e.g., optimal operation). The optimal synthesis of energy systems reveals such a two-stage character. The synthesis of energy systems involves multiple large time series such as energy demands and energy prices. Since problem size increases with the size of the time series, synthesis of energy systems leads to complex optimization problems. To reduce the problem size without loosing solution quality, we propose a method for time-series aggregation to identify typical periods. Typical periods retain the chronology of time steps, which enables modeling of energy systems, e.g., with storage units or start-up cost. The aim of the proposed method is to obtain few typical periods with few time steps per period, while accurately representing the objective function of the full time series, e.g., cost. Thus, we determine the error of time-series aggregation as the cost difference between operating the optimal design for the aggregated time series and for the full time series. Thereby, we rigorously bound the maximum performance loss of the optimal energy system design. In an initial step, the proposed method identifies the best length of typical periods by autocorrelation analysis. Subsequently, an adaptive procedure determines aggregated typical periods employing the clustering algorithm k-medoids, which groups similar periods into clusters and selects one representative period per cluster. Moreover, the number of time steps per period is aggregated by a novel clustering algorithm maintaining chronology of the time steps in the periods. The method is iteratively repeated until the error falls below a threshold value. A case study based on a real-world synthesis problem of an energy system shows that time-series aggregation from 8,760 time steps to 2 typical periods with each 2 time steps results in an error smaller than the optimality gap of

Pharmacodynamics of alfaxalone after single-dose intramuscular administration in red-eared sliders (Trachemys scripta elegans): a comparison of two different doses at two different ambient temperatures.

Science.gov (United States)

Shepard, Molly K; Divers, Stephen; Braun, Christina; Hofmeister, Erik H

2013-11-01

This study compares the pharmacodynamics of two different doses of alfaxalone administered intramuscularly (IM) to red-eared sliders at two ambient temperatures. Prospective blinded crossover experimental study. Nine adult female sliders (Trachemys scripta elegans). Following a 2-week acclimation at 22-25 °C, nine sliders were randomly assigned to receive alfaxalone, 10 mg kg(-1) (W10), or 20 mg kg(-1) (W20) IM. Each turtle received each dose, with a minimum 7-day washout period. A blinded observer evaluated heart rate (HR), palpebral and corneal reflexes, muscle relaxation, handling, and response to toe pinch at the following points: pre-injection, and 5, 12, 20, 30, 45, 60, and 120 minutes post-injection. Turtles then acclimated to 18-20 °C for 63 days, and the experiment was repeated in this lower-temperature environment, with treatment groups C10 (alfaxalone 10 mg kg(-1)) and C20 (alfaxalone 20 mg kg(-1)) subjected to the same crossover design. C10 and C20 groups had significantly lower intraanesthetic HR than W10 or W20, respectively. C10 and W20 were significantly more relaxed and easier to handle than W10. No significant differences were observed in palpebral reflex, nor responsiveness to the toe pinch stimulus. None of the turtles lost corneal reflex. W20 and C20 had prolonged recoveries, compared to low-dose groups within the same temperature environment. Recovery was also longer at C20 and C10 compared to W10. Turtles given 10 mg kg(-1) were more relaxed and easier to handle in cold than warm conditions. Warm turtles were more relaxed and easier to handle when given 20 mg kg(-1) than those given 10 mg kg(-1). Cold conditions correlated with lower HR and longer recovery time for each dose category. The turtles had dose-dependent and inconsistent responses to alfaxalone. Lower ambient temperature augmented the behavioral effects of this drug. © 2013 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.

Lactitol, a second-generation disaccharide for treatment of chronic portal-systemic encephalopathy. A double-blind, crossover, randomized clinical trial.

Science.gov (United States)

Uribe, M; Toledo, H; Perez, F; Vargas, F; Gil, S; Garcia-Ramos, G; Ravelli, G P; Guevara, L

1987-12-01

A double-blind crossover trial was performed to test the therapeutic usefulness and safety of lactitol, a beta-galactoside sorbitol, against lactose in 18 patients with chronic portal-systemic encephalopathy (PSE). The study included four periods: two for washout and two for lactitol and lactose administration. During washout periods, which lasted two weeks each, patients were stabilized with neomycin plus milk of magnesia. Lactitol and lactose were administered during four weeks each. Ten patients were randomly assigned to receive lactose (group A) and eight patients to receive lactitol (group B) first. PSE parameters, ie, mental state, number connection test performance, asterixis and blood ammonia levels were assessed fortnightly. Electroencephalographic tracings and stool pHs were evaluated at the end of each study period. After the first administration of lactose and lactitol, no statistically significant differences in PSE parameters were found. At the same stage, a significant stool acidification (P less than 0.05) was detected. It is concluded that lactitol seems to be safe and efficacious in treating patients with chronic PSE.

Reproductive solution for grade-two fluid model in two dimensions

Directory of Open Access Journals (Sweden)

L. Friz

2009-06-01

Full Text Available We treat the existence of reproductive solution (weak periodic solution of a second-grade fluid system in two dimensions, by using the Galerkin approximation method and compactness arguments.

Comparison of hydro-environmental impacts for ebb-only and two-way generation for a Severn Barrage

Science.gov (United States)

Ahmadian, Reza; Falconer, Roger A.; Bockelmann-Evans, Bettina

2014-10-01

Marine renewable energy is playing an increasing significant role in many parts of the world, mainly due to a rise in the awareness of climate change, and its detrimental effects, and the increasing cost of natural resources. The Severn Estuary, located between South West England and South Wales, has a tidal range of up to 14 m which makes it the second highest tidal range in the world. There are a number of barrage proposals amongst various marine renewable energy schemes proposed to be built in the estuary. The Cardiff-Weston STPG (Severn Tidal Power Group) Barrage, which would be one of the world's largest tidal renewable energy schemes if built, is one of the most publicised schemes to-date. This barrage would generate about 17 TWh/annum of power, which is approximately 5% of the UK's electricity consumption, whilst causing significant hydro-environmental and ecological impact on the estuary. This study mainly focuses on investigating the hydro-environmental impacts of the STPG barrage for the option of two-way generation, and compares this with the commonly investigated option of ebb-only generation. The impacts of the barrage were modelled by implementing a linked 1-D/2-D hydro-environmental model, with the capability of modelling several key environmental processes. The model predictions show that the hydro-environmental impacts of the barrage on the Severn Estuary and Bristol Channel, such as changes in the maximum velocity and reduction in suspended sediment and bacteria levels, were less significant for the two-way generation scheme when compared with the corresponding impacts for ebb-only generation.

A comparison of two low grade heat recovery options

International Nuclear Information System (INIS)

Walsh, Conor; Thornley, Patricia

2013-01-01

Low grade heat (LGH) recovery is one way of increasing industrial energy efficiency and reducing associated greenhouse gas emissions. The organic Rankine cycle (ORC) and condensing boiler are two options that can be used to recover low grade heat ( 2 annually, but the high carbon intensity of the coking process means this has a negligible influence (<1%) on the overall process lifecycle impacts. However, if the electricity generated offsets the external purchasing of electricity this results in favourable economic payback periods of between 3 and 6 years. The operation of a condensing boiler within a woodchip boiler reduces the fuel required to achieve an increased thermal output. The thermal efficiency gains reduce the lifecycle impacts by between 11 and 21%, and reflect payback periods as low as 1.5–2 years, depending on the condenser type and wood supply chain. The two case studies are used to highlight the difficulty in identifying LGH recovery solutions that satisfy multiple environmental, economic and wider objectives

Dependence of synchronization transitions on mean field approach in two-way coupled neural system

Science.gov (United States)

Shi, J. C.; Luo, M.; Huang, C. S.

2018-03-01

This work investigates the synchronization transitions in two-way coupled neural system by mean field approach. Results show that, there exists a critical noise intensity for the synchronization transitions, i.e., above (or below) the critical noise intensity, the synchronization transitions are decreased (or hardly change) with increasing the noise intensity. Meanwhile, the heterogeneity effect plays a negative role for the synchronization transitions, and above critical coupling strength, the heterogeneity effect on synchronization transitions can be negligible. Furthermore, when an external signal is introduced into the coupled system, the novel frequency-induced and amplitude-induced synchronization transitions are found, and there exist an optimal frequency and an optimal amplitude of external signal which makes the system to display the best synchronization transitions. In particular, it is observed that the synchronization transitions can not be further affected above critical frequency of external signal.

A two-step patterning process increases the robustness of periodic patterning in the fly eye.

Science.gov (United States)

Gavish, Avishai; Barkai, Naama

2016-06-01

Complex periodic patterns can self-organize through dynamic interactions between diffusible activators and inhibitors. In the biological context, self-organized patterning is challenged by spatial heterogeneities ('noise') inherent to biological systems. How spatial variability impacts the periodic patterning mechanism and how it can be buffered to ensure precise patterning is not well understood. We examine the effect of spatial heterogeneity on the periodic patterning of the fruit fly eye, an organ composed of ∼800 miniature eye units (ommatidia) whose periodic arrangement along a hexagonal lattice self-organizes during early stages of fly development. The patterning follows a two-step process, with an initial formation of evenly spaced clusters of ∼10 cells followed by a subsequent refinement of each cluster into a single selected cell. Using a probabilistic approach, we calculate the rate of patterning errors resulting from spatial heterogeneities in cell size, position and biosynthetic capacity. Notably, error rates were largely independent of the desired cluster size but followed the distributions of signaling speeds. Pre-formation of large clusters therefore greatly increases the reproducibility of the overall periodic arrangement, suggesting that the two-stage patterning process functions to guard the pattern against errors caused by spatial heterogeneities. Our results emphasize the constraints imposed on self-organized patterning mechanisms by the need to buffer stochastic effects. Author summary Complex periodic patterns are common in nature and are observed in physical, chemical and biological systems. Understanding how these patterns are generated in a precise manner is a key challenge. Biological patterns are especially intriguing, as they are generated in a noisy environment; cell position and cell size, for example, are subject to stochastic variations, as are the strengths of the chemical signals mediating cell-to-cell communication. The need

Music exposure and maturation of late preterm sleep-wake cycles: a randomised crossover trial.

Science.gov (United States)

Stokes, Adia; Agthe, Alexander G; El Metwally, Dina

2018-04-01

To determine the effect of music on sleep-wake cycle (SWC) patterns in late preterm neonates. In a masked crossover study, infants between 32 and 36 6/7 weeks gestation were randomised to music exposure either during the first six or last six hours of a 12-hour observation period. SWC characteristics were determined by continuous amplitude-integrated electroencephalography (aEEG) read by two coders masked to exposure sequence. Analysis was performed in paired comparisons. ANOVA was used to assess the effects of music exposure, period and crossover on SWC outcomes: (i) Burdjalov Scores (BS) during active sleep (AS) (ii) per cent and duration of quiet sleep (QS). Thirty infants were studied. A total of 222 QS cycles (median seven per patient; range five to 12) were analysed. Music exposure was associated with higher BS (F = 10.60, p = 0.0019) in AS and decreased interruptions during QS. The advanced postconceptual age (PCA) SWC pattern during AS was equivalent to a one-week mean. Number, duration and ratio of QS cycles did not change with music exposure. Music exposure elicits an increasing PCA pattern in AS and fewer interruptions in QS. Music may benefit sleep in late preterm infants. ©2017 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

Towards molecular doping effect on the electronic properties of two-dimensional layered materials

International Nuclear Information System (INIS)

Arramel; Wang, Q.; Zheng, Y.; Zhang, W.; Wee, A. T. S.

2016-01-01

In recent advancements of an atomically-thick, flat, and flexible two-dimensional (2D) material has attracted tremendous interest. Graphene and 2D layered semiconductors such as transition-metal dichalcogenides (TMDs) pave the way on the exploration of their unique layer-number dependent electronic and optical properties. The latter have a promising future on the microelectronics due to their sizeable bandgaps, i.e., the crossover from indirect-direct bandgap transition occurs as the thickness of TMDs is decreased to a monolayer. In this work, we systematically investigated the optimum growth parameter of chemical vapor deposition of MoS2 and WSe2, respectively. It turns out that the temperature and the duration growth plays role to produce a large area of TMDs monolayers. Our studies suggest that a well-controlled high quality of TMDs could serves as template and interlayer in the TMD-organic heterointerfaces. Thus it is potentially an attractive approach towards a wide-ranging application in optoelectronics, nanoelectronics and energy-harvesting applications. (paper)

Test Equality between Three Treatments under an Incomplete Block Crossover Design.

Science.gov (United States)

Lui, Kung-Jong

2015-01-01

Under a random effects linear additive risk model, we compare two experimental treatments with a placebo in continuous data under an incomplete block crossover trial. We develop three test procedures for simultaneously testing equality between two experimental treatments and a placebo, as well as interval estimators for the mean difference between treatments. We apply Monte Carlo simulations to evaluate the performance of these test procedures and interval estimators in a variety of situations. We note that the bivariate test procedure accounting for the dependence structure based on the F-test is preferable to the other two procedures when there is only one of the two experimental treatments has a non-zero effect vs. the placebo. We note further that when the effects of the two experimental treatments vs. a placebo are in the same relative directions and are approximately of equal magnitude, the summary test procedure based on a simple average of two weighted-least-squares (WLS) estimators can outperform the other two procedures with respect to power. When one of the two experimental treatments has a relatively large effect vs. the placebo, the univariate test procedure with using Bonferroni's equality can be still of use. Finally, we use the data about the forced expiratory volume in 1 s (FEV1) readings taken from a double-blind crossover trial comparing two different doses of formoterol with a placebo to illustrate the use of test procedures and interval estimators proposed here.

The Representation of Francoist Spain by Two British Women Travel Writers

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Mulligan Maureen

2016-12-01

Full Text Available This article offers a discussion of two books by British women which describe travels in Spain during the post-war period, that is, during the dictatorship of General Franco. The aim is to analyse how Spanish culture and society are represented in these texts, and to what extent the authors engage with questions of the ethics of travelling to Spain in this period. Two different forms of travel - by car, and by horse - also influence the way the travellers can connect with local people; and the individual’s interest in Spain as a historical site, or as a timeless escape from industrial northern Europe, similarly affect the focus of the accounts. The global politics of travel writing, and the distinction between colonial and cosmopolitan travel writers, are important elements in our understanding of the way a foreign culture is articulated for the home market. Women’s travel writing also has its own discursive history which we consider briefly. In conclusion, texts involve common discursive and linguistic strategies which have to negotiate the specificity of an individual’s travels in a particular time and place. The authors and books referred to are Rose Macaulay’s Fabled Shore: From the Pyrenees to Portugal (1949 and Penelope Chetwode’s Two Middle-Aged Ladies in Andalusia (1963.

Trawl catch composition during different fishing intensity periods in two Mediterranean demersal fishing grounds

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Pilar Sánchez

2007-12-01

Full Text Available The study was carried out in two fishing grounds on the Mediterranean continental shelf: one in the Adriatic Sea and one in the Catalan Sea. Samplings on board otter trawlers were performed from November 2002 to December 2003 in the Catalan Sea and from February 2003 to January 2004 in the Adriatic Sea. The Adriatic fishing ground was affected by high fishing intensity from January to June, while the Catalan area was highly exploited from September to February. Fishing activity in the Adriatic area was closed for 45 days, and 62 days in the Catalan area; both periods were in summer. Totals of 92 and 88 species were collected in the Adriatic and Catalan fishing grounds respectively. The species composition of the retained and discarded fractions showed close agreement between the two areas. Mullus barbatus showed very low discard rates in both areas, as well as Loligo vulgaris in the Catalan Sea and Merluccius merluccius in the Adriatic Sea. In both fishing grounds Squilla mantis showed high catch rates with low discards, except in March in the Catalan area. In the Adriatic Sea Liocarcinus depurator was characterized by large discard fractions. In both fishing grounds the retained fraction was slightly higher in the high fishing intensity periods than in the low intensity ones (Adriatic Sea: 0.613 vs 0.524; Catalan Sea: 0.597 vs 0.539, even though the Kruskall Wallis test revealed significant differences (p

Transmission of light through periodic arrays of square holes : from a metallic wire mesh to an array of tiny holes

NARCIS (Netherlands)

Bravo-Abad, J.; Martin-Moreno, L.; Garcia-Vidal, F.J.; Hendry, E.; Gómez Rivas, J.

2007-01-01

A complete landscape is presented of the electromagnetic coupling between square holes forming a two-dimensional periodic array in a metallic film. By combining both experimental and theoretical results along with a first-principles Fano model, we study the crossover between the physics of metallic

Local and sex-specific biases in crossover vs. noncrossover outcomes at meiotic recombination hot spots in mice

Science.gov (United States)

de Boer, Esther; Jasin, Maria; Keeney, Scott

2015-01-01

Meiotic recombination initiated by programmed double-strand breaks (DSBs) yields two types of interhomolog recombination products, crossovers and noncrossovers, but what determines whether a DSB will yield a crossover or noncrossover is not understood. In this study, we analyzed the influence of sex and chromosomal location on mammalian recombination outcomes by constructing fine-scale recombination maps in both males and females at two mouse hot spots located in different regions of the same chromosome. These include the most comprehensive maps of recombination hot spots in oocytes to date. One hot spot, located centrally on chromosome 1, behaved similarly in male and female meiosis: Crossovers and noncrossovers formed at comparable levels and ratios in both sexes. In contrast, at a distal hot spot, crossovers were recovered only in males even though noncrossovers were obtained at similar frequencies in both sexes. These findings reveal an example of extreme sex-specific bias in recombination outcome. We further found that estimates of relative DSB levels are surprisingly poor predictors of relative crossover frequencies between hot spots in males. Our results demonstrate that the outcome of mammalian meiotic recombination can be biased, that this bias can vary depending on location and cellular context, and that DSB frequency is not the only determinant of crossover frequency. PMID:26251527

Effect of fluoxetine on the pharmacokinetics of lansoprazole: a two-treatment period study in healthy male subjects.

Science.gov (United States)

Vlase, Laurian; Popa, Adina; Neag, Maria; Muntean, Dana; Leucuta, Sorin E

2011-10-01

Fluoxetine is an inhibitor of the main metabolizing enzymes of lansoprazole and could influence the pharmacokinetics of lansoprazole. The changes in lansoprazole pharmacokinetics could have clinical significance concerning the safety of the therapy. The aim of this study was to evaluate the pharmacokinetic interaction between fluoxetine and lansoprazole in healthy subjects. A dose of lansoprazole 30 mg, alone or in combination with fluoxetine 60 mg, was administered to 18 healthy male subjects in a two-treatment study design, separated by an 8-day period in which fluoxetine alone was administered as a single oral daily dose. Plasma concentrations of lansoprazole were determined during a 12-hour period following drug administration. Lansoprazole plasma concentrations were determined by a validated liquid chromatography-mass spectrometry method. The pharmacokinetic parameters of lansoprazole were calculated using non-compartmental analysis. In the two periods of treatment, the mean maximum plasma concentration (C(max)) values were 817 ng/mL (lansoprazole alone) and 1370 ng/mL (lansoprazole in combination with fluoxetine after pre-treatment with fluoxetine for 8 days) [p lansoprazole and suggest that the observed interaction may be clinically significant, although its clinical relevance has yet to be confirmed.

Outage performance of opportunistic two-way amplify-and-forward relaying with outdated channel state information

KAUST Repository

Hwang, Kyusung

2013-09-01

In this paper, we study the outage performance of an amplify-and-forward (AF)-based two-way relaying (TWR) system with multiple relays where a single relay selection is performed based on outdated channel state information (CSI). Specifically, we propose a single relay selection scheme in AF-based TWR system under outdated CSI conditions. With this policy, we offer a statistical analysis of the signal-to-noise ratio per hop and analyze the outage probability with asymmetric outage thresholds based on CSI-assisted AF protocol. Additionally, we provide the exact and asymptotic expressions based on the provided statistical/joint statistical analyses of a dual-hop AF transmission. Finally, we verify our analytical results with some selected computer-based simulation results. © 1972-2012 IEEE.

PL/SQL and Bind Variable: the two ways to increase the efficiency of Network Databases

Directory of Open Access Journals (Sweden)

Hitesh KUMAR SHARMA

2011-12-01

Full Text Available Modern data analysis applications are driven by the Network databases. They are pushing traditional database and data warehousing technologies beyond their limits due to their massively increasing data volumes and demands for low latency. There are three major challenges in working with network databases: interoperability due to heterogeneous data repositories, proactively due to autonomy of data sources and high efficiency to meet the application demand. This paper provides the two ways to meet the third challenge of network databases. This goal can be achieved by network database administrator with the usage of PL/SQL blocks and bind variable. The paper will explain the effect of PL/SQL block and bind variable on Network database efficiency to meet the modern data analysis application demand.

Effect of two complex training protocols of back squats in blood indicators of muscular damage in military athletes.

Science.gov (United States)

Ojeda, Álvaro Huerta; Ríos, Luis Chirosa; Barrilao, Rafael Guisado; Ríos, Ignacio Chirosa; Serrano, Pablo Cáceres

2016-05-01

[Purpose] The aim of this study was to determine the variations in the blood muscular damage indicators post application of two complex training programs for back squats. [Subjects and Methods] Seven military athletes were the subjects of this study. The study had a quasi-experimental cross-over intra-subject design. Two complex training protocols were applied, and the variables to be measured were cortisol, metabolic creatine kinase, and total creatine kinase. For the statistical analysis, Student's t-test was used. [Results] Twenty-four hours post effort, a significant decrease in cortisol level was shown for both protocols; however, the metabolic creatine kinase and total creatine kinase levels showed a significant increase. [Conclusion] Both protocols lowered the indicator of main muscular damage in the blood supply (cortisol). This proved that the work weight did not generate significant muscular damage in the 24-hour post-exercise period.

Data Quality Assessment of In Situ and Altimeter Observations Through Two-Way Intercomparison Methods

Science.gov (United States)

Guinehut, Stephanie; Valladeau, Guillaume; Legeais, Jean-Francois; Rio, Marie-Helene; Ablain, Michael; Larnicol, Gilles

2013-09-01

This proceeding presents an overview of the two-way inter-comparison activities performed at CLS for both space and in situ observation agencies and why this activity is a required step to obtain accurate and homogenous data sets that can then be used together for climate studies or in assimilation/validation tools. We first describe the work performed in the frame of the SALP program to assess the stability of altimeter missions through SSH comparisons with tide gauges (GLOSS/CLIVAR network). Then, we show how the SSH comparison between the Argo array and altimeter time series allows the detection of drifts or jumps in altimeter (SALP program) but also for some Argo floats (Ifremer/Coriolis center). Lastly, we describe how the combine use of altimeter and wind observations helps the detection of drogue loss of surface drifting buoys (GDP network) and allow the computation of a correction term for wind slippage.

Spin crossover in Fe(phen)2(NCS)2 complexes on metallic surfaces

Science.gov (United States)

Gruber, Manuel; Miyamachi, Toshio; Davesne, Vincent; Bowen, Martin; Boukari, Samy; Wulfhekel, Wulf; Alouani, Mebarek; Beaurepaire, Eric

2017-03-01

In this review, we give an overview on the spin crossover of Fe(phen)2(NCS)2 complexes adsorbed on Cu(100), Cu2N/Cu(100), Cu(111), Co/Cu(111), Co(100), Au(100), and Au(111) surfaces. Depending on the strength of the interaction of the molecules with the substrates, the spin crossover behavior can be drastically changed. Molecules in direct contact with non-magnetic metallic surfaces coexist in both the high- and low-spin states but cannot be switched between the two. Our analysis shows that this is due to a strong interaction with the substrate in the form of a chemisorption that dictates the spin state of the molecules through its adsorption geometry. Upon reducing the interaction to the surface either by adding a second molecular layer or inserting an insulating thin film of Cu2N, the spin crossover behavior is restored and molecules can be switched between the two states with the help of scanning tunneling microscopy. Especially on Cu2N, the two states of single molecules are stable at low temperature and thus allow the realization of a molecular memory. Similarly, the molecules decoupled from metallic substrates in the second or higher layers display thermally driven spin crossover as has been revealed by X-ray absorption spectroscopy. Finally, we discuss the situation when the complex is brought into contact with a ferromagnetic substrate. This leads to a strong exchange coupling between the Fe spin in the high-spin state and the magnetization of the substrate as deduced from spin-polarized scanning tunneling spectroscopy and ab initio calculation.

Bioequivalence of eslicarbazepine acetate from two different sources of its active product ingredient in healthy subjects.

Science.gov (United States)

Falcão, Amílcar; Lima, Ricardo; Sousa, Rui; Nunes, Teresa; Soares-da-Silva, Patrício

2013-06-01

To compare the bioavailability (BA) and pharmacokinetic (PK) properties and to demonstrate the bioequivalence (BE) between two active product ingredient (API) sources of eslicarbazepine acetate (ESL) in healthy volunteers. Forty healthy male and female subjects aged 18-40 years were randomized to treatment with 400 or 800 mg ESL marketed (MF) formulation [current active pharmaceutical ingredient (API) source] and 400 or 800 mg ESL to-be-marketed (TBM) formulation (new API source) under a gender-balanced, two-period, two-sequence crossover open-label study design. Subjects were assigned to receive either 400 or 800 mg ESL dose strengths, and each was randomly administered on two occasions--either a single oral tablet of MF or a single oral tablet of TBM--separated by a washout period of at least 7 days. Formulations were to be considered bioequivalent if, for both 400 or 800 mg ESL dosage strengths, the test (TBM)/reference (MF) geometric mean ratios (GMR) and 90% confidence intervals (90% CI) of the area under the plasma concentration-time curve (AUC) and peak plasma concentration (Cmax) were within the predetermined range of 80-125%. Test/reference GMR (90% CI) for the Cmax and AUC was respectively 100% (94-109%) and 96% (94-98%) following 400 mg ESL and 100% (95-105%) and 100% (97-103%) following 800 mg ESL. Oral tablet formulations of either 400 or 800 mg ESL from the new API source were found to be bioequivalent to the corresponding marketed Zebinix® formulation according to the regulatory definition of bioequivalence.

Relativistic BCS-BEC crossover at finite temperature and its application to color superconductivity

International Nuclear Information System (INIS)

He Lianyi; Zhuang Pengfei

2007-01-01

The nonrelativistic G 0 G formalism of BCS-BEC crossover at finite temperature is extended to relativistic fermion systems. The uncondensed pairs contribute a pseudogap to the fermion excitations. The theory recovers the BCS mean field approximation at zero temperature and the nonrelativistic results in a proper limit. For massive fermions, when the coupling strength increases, there exist two crossovers from the weak coupling BCS superfluid to the nonrelativistic BEC state and then to the relativistic BEC state. For color superconductivity at moderate baryon density, the matter is in the BCS-BEC crossover region, and the behavior of the pseudogap is quite similar to that found in high temperature superconductors

Reggeon effects in a geometrical model of elastic scattering. [Crossover curves, dip depth, scattering amplitude, 10 to 10,000 GeV

Energy Technology Data Exchange (ETDEWEB)

Dias de Deus, J [Instituto de Fisica e Matematica, Lisboa (Portugal); Kroll, P [Wuppertal Univ. (Gesamthochschule) (Germany, F.R.)

1976-08-21

The inclusion of secondary contributions Reggeons and real parts by changing the radial scale but exactly preserving geometrical scaling (GS) alloys an exclusion of GS to lower energies. The crossover curves in proton proton, Kp, and *pp are in this way correctly described. A GS formula relating two measurable quantities, the depth of the dip in proton proton scattering and the ratio of the real to immaginary part of the amplitude at t=0, is shown to be valid in the 10-1000 GeV region.

Improved orbits of two periodic comets: Tsuchinshan 1 and Tsuchinshan 2

International Nuclear Information System (INIS)

Szutowicz, S.

1986-01-01

The observations made during four apparitions of two comets were collected and the orbits of the comets were improved; 86 observations of Comet Tsuchinshan 1 and 50 observations of Comet Tsuchinshan 2 made in the period 1965-1985 were used. The orbit of Comet Tsuchinshan 1 was improved taking into account nongravitational effects in its motion as well as a displacement of the photometric center from the center of mass. The following values of nongravitational parameters and of observational parameter D were obtained: A 1 = 0.75953 x 10 -8 , A 2 0.00375 x 10 -8 , D = 0.34698 x 10 -3 . To link all observations of Comet Tsuchinshan 2 by one system of elements it was sufficient to add observational effects as a displacement of the photometric center from the center of mass. The following value of parameter D was obtained: D = 1.00200 x 10 -3 . The equations of motion of both comets were integrated backwards and forwards till 1992. Ephemerides for their next returns were computed. 6 refs., 5 tabs. (author)

Interactive Two-Way mHealth Interventions for Improving Medication Adherence: An Evaluation Using The Behaviour Change Wheel Framework

Science.gov (United States)

Amico, K Rivet; Atkins, Lou; Lester, Richard T

2018-01-01

Background Medication adherence is an important but highly complex set of behaviors, which for life-threatening and infectious diseases such as HIV carry critical consequences for individual and public health. There is growing evidence that mobile phone text messaging interventions (mHealth) connecting providers with patients positively impact medication adherence, particularly two-way engagement platforms that require bidirectional communication versus one-way in which responses are not mandatory. However, mechanisms of action have not been well defined. The Behavior Change Wheel is a comprehensive framework for behavior change that includes an all-encompassing model of behavior known as Capability Opportunity Motivation-Behavior and is complemented by a taxonomy of behavior change techniques. Evaluating mHealth interventions for medication adherence using these tools could provide useful insights that may contribute to optimizing their integration into the healthcare system and successful scaling-up. Objective This study aimed to help address the current knowledge gap regarding how two-way mHealth interventions for medication adherence may work by applying the Behavior Change Wheel to characterize WelTel: an interactive digital health outreach platform with robust evidence for improving adherence to antiretroviral therapy. Methods To characterize how WelTel may promote medication adherence, we applied the Behavior Change Wheel to systematically (1) generate a behavioral diagnosis through mapping known antiretroviral therapy adherence barriers onto the Capability Opportunity Motivation-Behavior model of behavior, (2) specify the behavior change techniques that WelTel delivers, (3) link identified behavior change techniques to corresponding intervention functions of the Behavior Change Wheel, and (4) connect these behavior change techniques and intervention functions to respective Capability Opportunity Motivation-Behavior influences on behavior to determine

Crossover of coherent Rabi oscillations in graphene

International Nuclear Information System (INIS)

Enamullah; Kumar, Vipin; Setlur, Girish S.

2012-01-01

We study the phenomenon of crossover of Rabi oscillations in graphene as a function of detuning - the difference between the frequency of the incident wave and interband energy (2v F |k|). It is shown by comparison with an exactly solved model with bands having linear dispersion but lacking pseudospin that this crossover is unique to graphene, attributable to the pseudospin character of the graphene hamiltonian. A group theoretic argument for why this model is solvable is given. We compute the nonlinear current using our formalism, the main prediction being the threshold behavior (with exponent equal to 1/2) of the slowly varying part of the current in frequency domain with threshold frequency being 2ω R 2 /ω (‘anomalous’ Rabi frequency) where ω R is the Rabi frequency for zero detuning. The novelty of our approach is the introduction of an alternative to the rotating wave approximation (RWA) (called asymptotic RWA here) which is argued to be important in demonstrating this crossover. We provide an interpolation method between these two regimes, that shows novel phenomena attributable to harmonic generation. A fully numerical solution to the Bloch equations verifies the analytical results and the various approximation schemes.

Speech perception with mono- and quadrupolar electrode configurations: a crossover study.

NARCIS (Netherlands)

Mens, L.H.M.; Berenstein, C.K.

2005-01-01

OBJECTIVE: To study the effect of two multipolar electrode configurations on speech perception, pitch perception, and the intracochlear electrical field. STUDY DESIGN: Crossover design; within subject. SETTING: Tertiary referral center. PATIENTS: Eight experienced adult cochlear implant users.

Crossover And MTF Characteristics Of A Tabular-Grain X-Ray Film

Science.gov (United States)

Huff, K. E.; Wagner, P. W.

1984-08-01

An orthochromatic x-ray film made with tabular silver halide grains has a significantly higher MTF when exposed with green-emitting intensifying screens than do conventional films with similar sensitometric properties. The primary reason for the improved MTF is a decrease in the amount of crossover exposure, i.e., exposure by light that has crossed the support one or more times. Two well-established sensitometric procedures for measuring crossover have been compared. One produces results accurate enough for calculations of MTF relationships. Calculated MTF relationships for tabulargrain and conventional films are compared with measured values.

Two definitions for genders

Science.gov (United States)

Shin, Philip

2011-10-01

By my definition, man and woman are the same fact to say. So man and woman have the same thinkings and same existence. But when I say again for man and woman, they are different for sex as the two different persons. They are different each two persons. As an example, by quantum, sex and color is different (the same existence and also different kind with quantum way-push and pull at the same time), also they are the same as they are our ID (hormones) and also dream matter. The same way, I hope we go to heaven and god will say you are the truth like it to be after the end of the world. I wish man and woman are different as it is more fun.

Reasons for Enrollment at a Spanish-English Two-Way Immersion Charter School among Highly Motivated Parents from a Diverse Community

Science.gov (United States)

Whiting, Erin F.; Feinauer, Erika

2011-01-01

This study builds on previous work to examine parent reasons for enrolling their children in a two-way immersion (TWI) charter school. This work goes beyond ethno linguistic background variables (language, ethnicity), to include other key variables such as education level, income, religion, household distance from school, and family structure.…

Predication of skin temperature and thermal comfort under two-way transient environments.

Science.gov (United States)

Zhou, Xin; Xiong, Jing; Lian, Zhiwei

2017-12-01

In this study, three transient environmental conditions consisting of one high-temperature phase within two low-temperature phases were developed, thus creating a temperature rise followed by a temperature fall. Twenty-four subjects (including 12 males and 12 females) were recruited and they underwent all three test scenarios. Skin temperature on seven body parts were measured during the whole period of the experiment. Besides, thermal sensation was investigated at specific moments by questionnaires. Thermal sensation models including PMV model, Fiala model and the Chinese model were applied to predict subjects' thermal sensation with comparisons carried out among them. Results show that most predicated thermal sensation by Chinese model lies within the range of 0.5 scale of the observed sensation vote, and it agrees best with the observed thermal sensation in transient thermal environment than PMV and Fiala model. Further studies should be carried out to improve performance of Chinese model for temperature alterations between "very hot" to "hot" environment, for prediction error in the temperature-fall situation of C5 (37-32°C) was over 0.5 scale. Copyright © 2017 Elsevier Ltd. All rights reserved.

Two Tones

DEFF Research Database (Denmark)

Palludan, Charlotte

2007-01-01

This article examines how kindergarten-children are differentiated and segregated through vocal practices and processes. The analysis is based on empirical data, which originate from a long ethnographic fieldwork in Denmark. The author presents two different language tones: "a teaching tone...... and an exchange tone" and shows a pattern in the ways the two tones are performed. While the teaching tone is heard in the interaction between the staff and the ethnic minority children, the ethnic majority children (the Danes) are addressed in the exchange tone. Pierre Bourdieu's concepts: "linguistic market......", "habitual inclinations" and "feeling for the game" are used as theoretical framework. When the author interprets and explains the language pattern as unequal distribution of recognition and as continuation of reproduction of a socio-cultural hierarchy among the children she relates to this framework...

JEROME BRUNER: DOS TEORÍAS COGNITIVAS, DOS FORMAS DE SIGNIFICAR, DOS ENFOQUES PARA LA ENSEÑANZA DE LA CIENCIA - JEROME BRUNER: TWO COGNITIVE THEORIES, TWO FORMS OF MEANING, TWO APPROACHES TO TEACHING SCIENCE

Directory of Open Access Journals (Sweden)

ÁNGELA CAMARGO URIBE

2010-06-01

Full Text Available This paper follows the work and the thought of the American psychologist Jerome Bruner,through the two very distinctive periods of his intellectual evolution; his period as a cognitive psychologist and his period as a cultural psychologist. After presenting the mainideas that characterize each psychological approach and briefly describing the speech gender representative to each way of knowing, the most relevant applications that Bruner’s ideas have inspired in the field of Science teaching and learning are considered. In this last respect, two periods of Bruner’s thought are discussed: the period of discovery learning and the period of science as a form of knowledge culturally describable.ResumenEl trabajo realiza un rastreo de la obra y el pensamiento del psicólogo norteamericano Jerome Bruner, durante las dos épocas más distinguibles de su evolución intelectual: su época de psicólogo cognitivista y su época de psicólogo culturalista. Luego de una presentación de las ideas principales que caracterizan estos dos enfoques psicológicos y de una breve descripción de las formas discursivas representativas de cada uno, el trabajo avanza hacia la identificación de las repercusiones más relevantes que la investigación y las ideas de Bruner han tenido para la enseñanza y el aprendizaje de las ciencias. En este último respecto, el trabajomantiene también la idea de dos periodos diferentes en el trabajo de Bruner: el periodo del aprendizaje por descubrimiento y el período del conocimiento científico como mundo posible culturalmente caracterizable.

A Case Study of Controlling Crossover in a Selection Hyper-heuristic Framework Using the Multidimensional Knapsack Problem.

Science.gov (United States)

Drake, John H; Özcan, Ender; Burke, Edmund K

2016-01-01

Hyper-heuristics are high-level methodologies for solving complex problems that operate on a search space of heuristics. In a selection hyper-heuristic framework, a heuristic is chosen from an existing set of low-level heuristics and applied to the current solution to produce a new solution at each point in the search. The use of crossover low-level heuristics is possible in an increasing number of general-purpose hyper-heuristic tools such as HyFlex and Hyperion. However, little work has been undertaken to assess how best to utilise it. Since a single-point search hyper-heuristic operates on a single candidate solution, and two candidate solutions are required for crossover, a mechanism is required to control the choice of the other solution. The frameworks we propose maintain a list of potential solutions for use in crossover. We investigate the use of such lists at two conceptual levels. First, crossover is controlled at the hyper-heuristic level where no problem-specific information is required. Second, it is controlled at the problem domain level where problem-specific information is used to produce good-quality solutions to use in crossover. A number of selection hyper-heuristics are compared using these frameworks over three benchmark libraries with varying properties for an NP-hard optimisation problem: the multidimensional 0-1 knapsack problem. It is shown that allowing crossover to be managed at the domain level outperforms managing crossover at the hyper-heuristic level in this problem domain.

Mutual research capacity strengthening: a qualitative study of two-way partnerships in public health research

Directory of Open Access Journals (Sweden)

Redman-MacLaren Michelle

2012-12-01

Full Text Available Abstract Introduction Capacity building has been employed in international health and development sectors to describe the process of ‘experts’ from more resourced countries training people in less resourced countries. Hence the concept has an implicit power imbalance based on ‘expert’ knowledge. In 2011, a health research strengthening workshop was undertaken at Atoifi Adventist Hospital, Solomon Islands to further strengthen research skills of the Hospital and College of Nursing staff and East Kwaio community leaders through partnering in practical research projects. The workshop was based on participatory research frameworks underpinned by decolonising methodologies, which sought to challenge historical power imbalances and inequities. Our research question was, “Is research capacity strengthening a two-way process?” Methods In this qualitative study, five Solomon Islanders and five Australians each responded to four open-ended questions about their experience of the research capacity strengthening workshop and activities: five chose face to face interview, five chose to provide written responses. Written responses and interview transcripts were inductively analysed in NVivo 9. Results Six major themes emerged. These were: Respectful relationships; Increased knowledge and experience with research process; Participation at all stages in the research process; Contribution to public health action; Support and sustain research opportunities; and Managing challenges of capacity strengthening. All researchers identified benefits for themselves, their institution and/or community, regardless of their role or country of origin, indicating that the capacity strengthening had been a two-way process. Conclusions The flexible and responsive process we used to strengthen research capacity was identified as mutually beneficial. Using community-based participatory frameworks underpinned by decolonising methodologies is assisting to redress

Clinostatic rotation decreases crossover frequencies in the fungus Sordaria macrospora Auersw.

Science.gov (United States)

Henkel, J; Hock, B

1991-12-01

Two-factor crosses between the non-allelic spore colour mutants r2 and lu of the fungus Sordaria macrospora were used to investigate the effect of clinostatic rotation (= simulated weightlessness) on crossover frequencies. The experiment was carried out with different rotary directions at a rotary rate of 4 rpm. Second-division segregations of the gene lu, which result from crossover between the gene locus and centromere, are significantly smaller in the clinostat experiments than in the static controls. No differences were found between the two rotary directions. A similar influence of clinostatic rotation was not observed for the gene r2 which in contrast to the lu locus is located very close to the centromere. The suitability of this approach for the investigation of the effect of space flight conditions on cytogenetic processes is pointed out.

A Community Medical Service Using Two-Way Radio

African Journals Online (AJOL)

1974-09-21

Sep 21, 1974 ... have to go to Durban. Patients tend to resist being referred to other centres. Tab"c 1 shows the work:oad of the hospital for the. 12-month period from April 1972 to March 1973. The hospital provides training for staff-nurses and midwives, and a doctor must participate in this programme. The doctor, as ...

The biological basis of a universal constraint on color naming: cone contrasts and the two-way categorization of colors.

Science.gov (United States)

Xiao, Youping; Kavanau, Christopher; Bertin, Lauren; Kaplan, Ehud

2011-01-01

Many studies have provided evidence for the existence of universal constraints on color categorization or naming in various languages, but the biological basis of these constraints is unknown. A recent study of the pattern of color categorization across numerous languages has suggested that these patterns tend to avoid straddling a region in color space at or near the border between the English composite categories of "warm" and "cool". This fault line in color space represents a fundamental constraint on color naming. Here we report that the two-way categorization along the fault line is correlated with the sign of the L- versus M-cone contrast of a stimulus color. Moreover, we found that the sign of the L-M cone contrast also accounted for the two-way clustering of the spatially distributed neural responses in small regions of the macaque primary visual cortex, visualized with optical imaging. These small regions correspond to the hue maps, where our previous study found a spatially organized representation of stimulus hue. Altogether, these results establish a direct link between a universal constraint on color naming and the cone-specific information that is represented in the primate early visual system.

Hyperon puzzle, hadron-quark crossover and massive neutron stars

Energy Technology Data Exchange (ETDEWEB)

Masuda, Kota [The University of Tokyo, Department of Physics, Tokyo (Japan); Nishina Center, RIKEN, Theoretical Research Division, Wako (Japan); Hatsuda, Tetsuo [Nishina Center, RIKEN, Theoretical Research Division, Wako (Japan); The University of Tokyo, Kavli IPMU (WPI), Chiba (Japan); Takatsuka, Tatsuyuki [Nishina Center, RIKEN, Theoretical Research Division, Wako (Japan)

2016-03-15

Bulk properties of cold and hot neutron stars are studied on the basis of the hadron-quark crossover picture where a smooth transition from the hadronic phase to the quark phase takes place at finite baryon density. By using a phenomenological equation of state (EOS) ''CRover'', which interpolates the two phases at around 3 times the nuclear matter density (ρ{sub 0}), it is found that the cold NSs with the gravitational mass larger than 2M {sub CircleDot} can be sustained. This is in sharp contrast to the case of the first-order hadron-quark transition. The radii of the cold NSs with the CRover EOS are in the narrow range (12.5 ± 0.5) km which is insensitive to the NS masses. Due to the stiffening of the EOS induced by the hadron-quark crossover, the central density of the NSs is at most 4 ρ{sub 0} and the hyperon-mixing barely occurs inside the NS core. This constitutes a solution of the long-standing hyperon puzzle. The effect of color superconductivity (CSC) on the NS structures is also examined with the hadron-quark crossover. For the typical strength of the diquark attraction, a slight softening of the EOS due to two-flavor CSC (2SC) takes place and the maximum mass is reduced by about 0.2M {sub CircleDot}. The CRover EOS is generalized to the supernova matter at finite temperature to describe the hot NSs at birth. The hadron-quark crossover is found to decrease the central temperature of the hot NSs under isentropic condition. The gravitational energy release and the spin-up rate during the contraction from the hot NS to the cold NS are also estimated. (orig.)

Hyperon puzzle, hadron-quark crossover and massive neutron stars

International Nuclear Information System (INIS)

Masuda, Kota; Hatsuda, Tetsuo; Takatsuka, Tatsuyuki

2016-01-01

Bulk properties of cold and hot neutron stars are studied on the basis of the hadron-quark crossover picture where a smooth transition from the hadronic phase to the quark phase takes place at finite baryon density. By using a phenomenological equation of state (EOS) ''CRover'', which interpolates the two phases at around 3 times the nuclear matter density (ρ 0 ), it is found that the cold NSs with the gravitational mass larger than 2M CircleDot can be sustained. This is in sharp contrast to the case of the first-order hadron-quark transition. The radii of the cold NSs with the CRover EOS are in the narrow range (12.5 ± 0.5) km which is insensitive to the NS masses. Due to the stiffening of the EOS induced by the hadron-quark crossover, the central density of the NSs is at most 4 ρ 0 and the hyperon-mixing barely occurs inside the NS core. This constitutes a solution of the long-standing hyperon puzzle. The effect of color superconductivity (CSC) on the NS structures is also examined with the hadron-quark crossover. For the typical strength of the diquark attraction, a slight softening of the EOS due to two-flavor CSC (2SC) takes place and the maximum mass is reduced by about 0.2M CircleDot . The CRover EOS is generalized to the supernova matter at finite temperature to describe the hot NSs at birth. The hadron-quark crossover is found to decrease the central temperature of the hot NSs under isentropic condition. The gravitational energy release and the spin-up rate during the contraction from the hot NS to the cold NS are also estimated. (orig.)

SER Derivation and Power Optimization of a Two-Way MultiRelay Cooperative Communication System

Directory of Open Access Journals (Sweden)

Shakeel-Ur-Rehman Rehman

2014-01-01

Full Text Available In this paper, we consider Rayleigh fading based cooperative communication system with AaF (Amplify and Forward relaying using multiple relays. We take spectrally efficient two-way model of cooperative communication terminals and formulate performance evaluation framework in terms of SER (Symbol Error Rate. We not only consider fading channel for this performance evaluation but also consider the effect of relay terminal location into our model which does not require any CSI (Channel State Information at transmitting nodes. We have proposed power allocation framework for these nodes and analytically derived SER performance results. We have numerically evaluated this framework for power optimization as well as minimizing required SER. Significant performance improvement as compared with equal power sharing among the cooperating terminals is achieved using our proposed framework. It is shown that virtual cooperative antenna configurations is able to demonstrate up to 3dB gain as compared with co-located antenna configurations. Thus incorporating relay location information for performance evaluation results significant power savings

Genetic Algorithm for Traveling Salesman Problem with Modified Cycle Crossover Operator

Directory of Open Access Journals (Sweden)

Abid Hussain

2017-01-01

Full Text Available Genetic algorithms are evolutionary techniques used for optimization purposes according to survival of the fittest idea. These methods do not ensure optimal solutions; however, they give good approximation usually in time. The genetic algorithms are useful for NP-hard problems, especially the traveling salesman problem. The genetic algorithm depends on selection criteria, crossover, and mutation operators. To tackle the traveling salesman problem using genetic algorithms, there are various representations such as binary, path, adjacency, ordinal, and matrix representations. In this article, we propose a new crossover operator for traveling salesman problem to minimize the total distance. This approach has been linked with path representation, which is the most natural way to represent a legal tour. Computational results are also reported with some traditional path representation methods like partially mapped and order crossovers along with new cycle crossover operator for some benchmark TSPLIB instances and found improvements.

Approach of the Two-way Influence Between Lean and Green Manufacturing and its Connection to Related Organisational Areas

Directory of Open Access Journals (Sweden)

Rodrigo Salvador

2017-07-01

Full Text Available Initiatives toward Lean and Green Manufacturing are given mainly due to organisational response to current market’s economic and environmental pressures. This paper, therefore, aims to present a brief discussion based on a literature review of the potential two-way influence between Lean and Green Manufacturing and its role on the main organisational areas with a closer relationship to such approaches, which were observed to be more extensively discussed in the literature. Naturally lean practises seem more likely to deploy into green outcomes, though the other way around can also occur. There is some blur on the factual integration of both themes, as some authors suggest. Notwhithstanding, they certainly present certain synergy. Thereupon, further research is needed to unveil the real ties, overlaps and gaps between these approaches.

Periodic rotation noise induced by the crosstalk between two beat-frequency signals in multi-oscillator ring laser gyros

International Nuclear Information System (INIS)

Lu, Guangfeng; Wang, Zhiguo; Fan, Zhenfang; Luo, Hui

2014-01-01

Periodic rotation noise in the outputs of multi-oscillator ring laser gyros (MRLGs) is investigated in this paper for the first time. It is proved theoretically and experimentally that noise is induced by the crosstalk between two beat-frequency signals, which are combined from the left and right circularly polarized counter-propagating beams in MRLGs. Theoretical analysis and experimental results also indicate that the fundamental frequency of this noise is equal to the frequency difference between the two beat-frequency signals and the amplitude of the fundamental component is proportional to the crosstalk ratio between the two beat-frequency signals. Further, the amplitude of the nth-order component is proportional to the nth power of the crosstalk ratio. (paper)

Relative bioavailability of generic and branded 250-mg and 500-mg oral chlorphenesin carbamate tablets in healthy Korean volunteers: a single-dose, randomized-sequence, open-label, two-period crossover trial.

Science.gov (United States)

Yu, Ji-young; Song, Hyun Ho; Kim, Bo Gyeom; Park, Hyeon Ju; Choi, Kwang Sik; Kwon, Young Ee

2009-11-01

Chlorphenesin carbamate is a skeletal muscle relaxant approved in Korea for use in the treatment of pain and discomfort related to skeletal muscle trauma and inflammation. The aim of this study was to assess the bioequivalence of a generic formulation of chlorphenesin carbamate at doses of 250 and 500 mg and 2 branded formulations of the same doses in healthy Korean adults. This single-dose, randomized-sequence, open-label, 2-period crossover study was conducted in healthy Korean male and female volunteers. Subjects were assigned to receive, in a randomized sequence, a single dose of the generic (test) and branded (reference) formulations of chlorphenesin carbamate at a dose of 250 or 500 mg. Blood samples were drawn at 0, 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 9, 12, and 15 hours after administration. Pharmacokinetic properties (C(max), T(max), AUC(0-t) AUC(0-infinity), t(1/2), and ke) were determined using HPLC. The formulations were to be considered bioequivalent if the 90% CIs of the treatment ratios of the geometric means of C(max) and AUC(0-t) were within a predetermined range of log 0.80 to log 1.25 based on regulatory criteria. Tolerability was assessed by monitoring for adverse events (AEs) on physical examination and/or e-mail and personal interview at the beginning and end of each study period. Twenty-eight subjects (22 men, 6 women) received chlorphenesin carbamate at the 250-mg dose, and 24 male subjects received the 500-mg dose. The mean (SD) ages of the subjects were 24.0 (2.6) and 24.0 (1.9) years in the 250- and 500-mg groups, respectively. No significant differences were found between the test and reference formulations (90% CIs: C(max), 1.0048-1.1153 with the 250-mg dose and 0.9630-1.1189 with the 500-mg dose; AUC(0-t), 0.9882-1.0546 and 0.9842-1.0578, respectively). No clinically significant AEs (upper gastric pain, abdominal bloating, pyrexia, edema, nausea, heartburn, constipation, headache, dizziness, drowsiness, or fatigue) were reported throughout

Comparison of application of various crossovers in solving inhomogeneous minimax problem modified by Goldberg model

Science.gov (United States)

Kobak, B. V.; Zhukovskiy, A. G.; Kuzin, A. P.

2018-05-01

This paper considers one of the classical NP complete problems - an inhomogeneous minimax problem. When solving such large-scale problem, there appear difficulties in obtaining an exact solution. Therefore, let us propose getting an optimum solution in an acceptable time. Among a wide range of genetic algorithm models, let us choose the modified Goldberg model, which earlier was successfully used by authors in solving NP complete problems. The classical Goldberg model uses a single-point crossover and a singlepoint mutation, which somewhat decreases the accuracy of the obtained results. In the article, let us propose using a full two-point crossover with various mutations previously researched. In addition, the work studied the necessary probability to apply it to the crossover in order to obtain results that are more accurate. Results of the computation experiment showed that the higher the probability of a crossover, the higher the quality of both the average results and the best solutions. In addition, it was found out that the higher the values of the number of individuals and the number of repetitions, the closer both the average results and the best solutions to the optimum. The paper shows how the use of a full two-point crossover increases the accuracy of solving an inhomogeneous minimax problem, while the time for getting the solution increases, but remains polynomial.

Atomic Evolution and Entanglement of Two Qubits in Photon Superfluid

Science.gov (United States)

Yin, Miao; Zhang, Xiongfeng; Deng, Yunlong; Deng, Huaqiu

2018-03-01

By using reservoir theory, we investigate the evolution of an atom placed in photon superfluid and study the entanglement properties of two qubits interacting with photon superfluid. It is found that the atomic decay rate in photon superfluid changes periodically with position of the atom and the decay rate can be inhibited compared to that in usual electromagnetic environment without photon superfluid. It is also found that when two atoms are separately immersed in their own local photon-superfluid reservoir, the entanglement sudden death or birth occurs or not only depends on the initial state of the qubits. What is more, we find a possible case that the concurrence between two qubits can remain a constant value by choosing proper values of parameters of the system, which may provide a new way to preserve quantum entanglement.

Pin level neutronic - thermal hydraulic two-way-coupling using DYN3D-SP3 and SUBCHANFLOW

International Nuclear Information System (INIS)

Torres, Armando Gomez; Espinoza, Victor Sanchez; Imke, Uwe; Juan, Rafael Macian

2011-01-01

Nowadays several Reactor Dynamic Codes, (RDC) are able to solve the diffusion equation or even the transport equation (SP3 approximation) considering feedback parameters coming from the thermalhydraulic (TH) core behavior. These kinds of codes (DYN3D, PARCS, among others) usually contain a 1D two phase flow thermalhydraulic model capable to pass them assembly averaged feedback parameters. At fuel assembly base this nodal coupling is completely a two way coupling. The Neutronic part calculates the mean power of the whole assembly and passes it to the TH part in order to actualize the heat source. In turn, the TH model passes the assembly-based feedback parameters to the neutronic code for actualizing the nodal cross sections. The process will be repeated until convergence. At pin level, the current situation is somehow different. Although the neutronic solver can pass the pin power distribution in every sub - node (pin distribution), the 1-D TH model will average the pin power distribution to assembly-based scale and will give back assembly averaged feedbacks to the neutronic part for cross sections up-date (one and a half way coupling), leading to information loss in the calculation. A new coupled program system DYNSUB was developed by coupling DYN3D-SP3 and SUBCHANFLOW at pin level. DYNSUB was used to analyze stationary PWR minicore problems at pin-level. The comparison of the Keff predicted by DYNSUB with the one calculated by DYN3D-SP3 (coarse TH solution) shows small differences of up to 26 pcm. Differences up to 4.5% were found in the radial distribution of the pin power. The local safety parameters such as cladding and fuel temperature predicted with DYNSUB shows larger deviations compared with the ones obtained with DYN3D-SP3. These differences may increase when analyzing transients. (author)

Analysis of stability and bifurcations of fixed points and periodic solutions of a lumped model of neocortex with two delays

NARCIS (Netherlands)

Visser, Sid; Meijer, Hil G.E.; van Putten, Michel J.A.M.; van Gils, Stephan A.

2012-01-01