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Sample records for two-color fluorescence coincidence

  1. Two dye combinations suitable for two-color/two-dye laser-induced fluorescence thermography for ethanol

    Science.gov (United States)

    Fenner, Andreas; Stephan, Peter

    2017-06-01

    This paper presents two dye combinations suitable for two-color/two-dye laser-induced fluorescence thermography for ethanol. Besides the temperature dependency of the fluorescence, the influences of laser fluence, dye concentration, pressure, dissolved air, and photobleaching are also discussed. The experimental data are compared with models and data available in literature. Based on this, parameter ranges for two-color/two-dye laser-induced fluorescence thermography applications can be determined.

  2. Simulation of Far-Field Superresolution Fluorescence Imaging with Two-Color One-Photon Excitation of Reversible Photoactivatable Protein

    Institute of Scientific and Technical Information of China (English)

    WANG Chen; QIAO Ling-Ling; MAO Zheng-Le

    2011-01-01

    We propose to achieve far-field super-resolution imaging by using offset two-color one-photon (2C1P) excitation of reversible photoactivatable fluorescence proteins. Due to the distinctive photoswitching performance of the proteins, such as dronpa, the fluorescence emission will only come from the overlapped region of activation beam and excitation beam. The analysis solution of rate equation shows that the resolution of offset 2C1P microscope is "engineered" by laser power of excitation and activation beams and the power ratio between them. Superior lateral and transverse resolution is theoretically demonstrated compared with conventional fluorescence scanning microscopy.%@@ We propose to achieve far-field super-resolution imaging by using offset two-color one-photon(2C1P) excitation of reversible photoactivatable fluorescence proteins.Due to the distinctive photoswitching performance of the proteins,such as dronpa,the fluorescence emission will only come from the overlapped region of activation beam and excitation beam.The analysis solution of rate equation shows that the resolution of offset 2C1P microscope is "engineered" by laser power of excitation and activation beams and the power ratio between them.Superior lateral and transverse resolution is theoretically demonstrated compared with conventional fluorescence scanning microscopy.

  3. Two-color fluorescent (near-infrared and visible) triphasic perfluorocarbon nanoemuslions.

    Science.gov (United States)

    Patel, Sravan Kumar; Patrick, Michael J; Pollock, John A; Janjic, Jelena M

    2013-10-01

    Design and development of a new formulation as a unique assembly of distinct fluorescent reporters with nonoverlapping fluorescence spectra and a F19 magnetic resonance imaging agent into colloidally and optically stable triphasic nanoemulsion are reported. Specifically, a cyanine dye-perfluorocarbon (PFC) conjugate was introduced into the PFC phase of the nanoemulsion and a near-infrared dye was introduced into the hydrocarbon (HC) layer. To the best of our knowledge, this is the first report of a triphasic nanoemulsion system where each oil phase, HC, and PFC are fluorescently labeled and formulated into an optically and colloidally stable nanosystem. Having, each oil phase separately labeled by a fluorescent dye allows for improved correlation between in vivo imaging and histological data. Further, dual fluorescent labeling can improve intracellular tracking of the nanodroplets and help assess the fate of the nanoemulsion in biologically relevant media. The nanoemulsions were produced by high shear processing (microfluidization) and stabilized with biocompatible nonionic surfactants resulting in mono-modal size distribution with average droplet size less than 200 nm. Nanoemulsions demonstrate excellent colloidal stability and only moderate changes in the fluorescence signal for both dyes. Confocal fluorescence microscopy of macrophages exposed to nanoemulsions shows the presence of both fluorescence agents in the cytoplasm.

  4. Monitoring membrane binding and insertion of peptides by two-color fluorescent label.

    Science.gov (United States)

    Postupalenko, V Y; Shvadchak, V V; Duportail, G; Pivovarenko, V G; Klymchenko, A S; Mély, Y

    2011-01-01

    Herein, we developed an approach for monitoring membrane binding and insertion of peptides using a fluorescent environment-sensitive label of the 3-hydroxyflavone family. For this purpose, we labeled the N-terminus of three synthetic peptides, melittin, magainin 2 and poly-l-lysine capable to interact with lipid membranes. Binding of these peptides to lipid vesicles induced a strong fluorescence increase, which enabled to quantify the peptide-membrane interaction. Moreover, the dual emission of the label in these peptides correlated well with the depth of its insertion measured by the parallax quenching method. Thus, in melittin and magainin 2, which show deep insertion of their N-terminus, the label presented a dual emission corresponding to a low polar environment, while the environment of the poly-l-lysine N-terminus was rather polar, consistent with its location close to the bilayer surface. Using spectral deconvolution to distinguish the non-hydrated label species from the hydrated ones and two photon fluorescence microscopy to determine the probe orientation in giant vesicles, we found that the non-hydrated species were vertically oriented in the bilayer and constituted the best indicators for evaluating the depth of the peptide N-terminus in membranes. Thus, this label constitutes an interesting new tool for monitoring membrane binding and insertion of peptides.

  5. Tunable Two-color Luminescence and Host–guest Energy Transfer of Fluorescent Chromophores Encapsulated in Metal-Organic Frameworks

    Science.gov (United States)

    Yan, Dongpeng; Tang, Yanqun; Lin, Heyang; Wang, Dan

    2014-01-01

    Co-assembly of chromophore guests with host matrices can afford materials which have photofunctionalities different from those of individual components. Compared with clay and zeolite materials, the use of metal–organic frameworks (MOFs) as a host structure for fabricating luminescent host–guest materials is still at an early stage. Herein, we report the incorporation of a laser dye, 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran (DCM), into stilbene-based and naphthalene-based MOF systems. The resulting materials exhibit blue/red two-color emission, and the intensity ratio of blue to red fluorescence varies in different planes within the MOF crystal as detected by 3D confocal fluorescence microscopy. The observed changes in ratiometric fluorescence suggest the occurrence of energy transfer from MOF host to DCM molecules, which can be further confirmed by periodic density functional theoretical (DFT) calculations. Moreover, selective changes in luminescence behavior are observed on treating the guest@MOF samples with volatile organic compounds (methanol, acetone and toluene), indicating that these host–guest systems have potential applications as fluorescence sensors. It can be expected that by rational selection of MOF hosts and guest chromophores with suitable emissive colors and energy levels, a wide variety of multi-color luminescent and energy-transfer systems can readily be prepared in a similar manner. PMID:24614015

  6. Flow cytometric quantification of all phases of the cell cycle and apoptosis in a two-color fluorescence plot.

    Directory of Open Access Journals (Sweden)

    Christine Vignon

    Full Text Available An optimal technology for cell cycle analysis would allow the concomitant measurement of apoptosis, G0, G1, S, G2 and M phases in combination with cell surface phenotyping. We have developed an easy method in flow cytometry allowing this discrimination in an only two-color fluorescent plot. It is based on the concomitant use of 7-amino-actinomycin D and the antibodies anti-Ki67 and anti-phospho(Ser10-histone H3, both conjugated to Alexa Fluor®488 to discriminate G0 and M phases, respectively. The method is particularly valuable in a clinical setting as verified in our laboratory by analyzing human leukemic cells from marrow samples or after exposure to cell cycle modifiers.

  7. Development of Two Color Fluorescent Imager and Integrated Fluidic System for Nanosatellite Biology Applications

    Science.gov (United States)

    Wu, Diana Terri; Ricco, Antonio Joseph; Lera, Matthew P.; Timucin, Linda R.; Parra, Macarena P.

    2012-01-01

    Nanosatellites offer frequent, low-cost space access as secondary payloads on launches of larger conventional satellites. We summarize the payload science and technology of the Microsatellite in-situ Space Technologies (MisST) nanosatellite for conducting automated biological experiments. The payload (two fused 10-cm cubes) includes 1) an integrated fluidics system that maintains organism viability and supports growth and 2) a fixed-focus imager with fluorescence and scattered-light imaging capabilities. The payload monitors temperature, pressure and relative humidity, and actively controls temperature. C. elegans (nematode, 50 m diameter x 1 mm long) was selected as a model organism due to previous space science experience, its completely sequenced genome, size, hardiness, and the variety of strains available. Three strains were chosen: two green GFP-tagged strains and one red tdTomato-tagged strain that label intestinal, nerve, and pharyngeal cells, respectively. The integrated fluidics system includes bioanalytical and reservoir modules. The former consists of four 150 L culture wells and a 4x5 mm imaging zone the latter includes two 8 mL fluid reservoirs for reagent and waste storage. The fluidic system is fabricated using multilayer polymer rapid prototyping: laser cutting, precision machining, die cutting, and pressure-sensitive adhesives it also includes eight solenoid-operated valves and one mini peristaltic pump. Young larval-state (L2) nematodes are loaded in C. elegans Maintenance Media (CeMM) in the bioanalytical module during pre-launch assembly. By the time orbit is established, the worms have grown to sufficient density to be imaged and are fed fresh CeMM. The strains are pumped sequentially into the imaging area, imaged, then pumped into waste. Reagent storage utilizes polymer bags under slight pressure to prevent bubble formation in wells or channels. The optical system images green and red fluorescence bands by excitation with blue (473 nm peak

  8. Two-color widefield fluorescence microendoscopy enables multiplexed molecular imaging in the alveolar space of human lung tissue

    Science.gov (United States)

    Krstajić, Nikola; Akram, Ahsan R.; Choudhary, Tushar R.; McDonald, Neil; Tanner, Michael G.; Pedretti, Ettore; Dalgarno, Paul A.; Scholefield, Emma; Girkin, John M.; Moore, Anne; Bradley, Mark; Dhaliwal, Kevin

    2016-04-01

    We demonstrate a fast two-color widefield fluorescence microendoscopy system capable of simultaneously detecting several disease targets in intact human ex vivo lung tissue. We characterize the system for light throughput from the excitation light emitting diodes, fluorescence collection efficiency, and chromatic focal shifts. We demonstrate the effectiveness of the instrument by imaging bacteria (Pseudomonas aeruginosa) in ex vivo human lung tissue. We describe a mechanism of bacterial detection through the fiber bundle that uses blinking effects of bacteria as they move in front of the fiber core providing detection of objects smaller than the fiber core and cladding (˜3 μm). This effectively increases the measured spatial resolution of 4 μm. We show simultaneous imaging of neutrophils, monocytes, and fungus (Aspergillus fumigatus) in ex vivo human lung tissue. The instrument has 10 nM and 50 nM sensitivity for fluorescein and Cy5 solutions, respectively. Lung tissue autofluorescence remains visible at up to 200 fps camera acquisition rate. The optical system lends itself to clinical translation due to high-fluorescence sensitivity, simplicity, and the ability to multiplex several pathological molecular imaging targets simultaneously.

  9. Two-color two-photon excited fluorescence of indole: Determination of wavelength-dependent molecular parameters

    Energy Technology Data Exchange (ETDEWEB)

    Herbrich, Sebastian; Al-Hadhuri, Tawfik; Gericke, Karl-Heinz, E-mail: k.Gericke@tu-bs.de [Institut für Physikalische und Theoretische Chemie, TU Braunschweig, Hans-Sommer-Straße 10, 38106 Braunschweig (Germany); Shternin, Peter S., E-mail: pshternin@gmail.com; Vasyutinskii, Oleg S., E-mail: osv@pms.ioffe.ru [Ioffe Institute, Politekhnicheskaya 26, 194021 St. Petersburg (Russian Federation); St. Petersburg Polytechnic University, Politekhnicheskaya 29, St. Petersburg 195251 (Russian Federation); Smolin, Andrey G. [Ioffe Institute, Politekhnicheskaya 26, 194021 St. Petersburg (Russian Federation)

    2015-01-14

    We present a detailed study of two-color two-photon excited fluorescence in indole dissolved in propylene glycol. Femtosecond excitation pulses at effective wavelengths from 268 to 293.33 nm were used to populate the two lowest indole excited states {sup 1}L{sub a} and {sup 1}L{sub b} and polarized fluorescence was then detected. All seven molecular parameters and the two-photon polarization ratio Ω containing information on two-photon absorption dynamics, molecular lifetime τ{sub f}, and rotation correlation time τ{sub rot} have been determined from experiment and analyzed as a function of the excitation wavelength. The analysis of the experimental data has shown that {sup 1}L{sub b}–{sup 1}L{sub a} inversion occurred under the conditions of our experiment. The two-photon absorption predominantly populated the {sup 1}L{sub a} state at all excitation wavelengths but in the 287–289 nm area which contained an absorption hump of the {sup 1}L{sub b} state 0-0 origin. The components of the two-photon excitation tensor S were analyzed giving important information on the principal tensor axes and absorption symmetry. The results obtained are in a good agreement with the results reported by other groups. The lifetime τ{sub f} and the rotation correlation time τ{sub rot} showed no explicit dependence on the effective excitation wavelength. Their calculated weighted average values were found to be τ{sub f} = 3.83 ± 0.14 ns and τ{sub rot} = 0.74 ± 0.06 ns.

  10. Identification of the origin of marker chromosomes by two-color fluorescence in situ hybridization and polymerase chain reaction in azoospermic patients.

    Science.gov (United States)

    Wei, C L; Cheng, J L; Yang, W C; Li, L Y; Cheng, H C; Fu, J J

    2015-11-19

    Y chromosomal microdeletions at the azoospermia factor locus and chromosome abnormalities have been implicated as the major causes of idiopathic male infertility. A marker chromosome is a structurally abnormal chromosome in which no part can be identified by cytogenetics. In this study, to identify the origin of the marker chromosomes and to perform a genetic diagnosis of patients with azoospermia, two-color fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) techniques were carried out. The marker chromosomes for the two patients with azoospermia originated in the Y chromosome; it was ascertained that the karyotype of both patients was 46,X, ish del(Y)(q11)(DYZ3+, DXZ1-). The combination of two-color FISH and PCR techniques is an important method for the identification of the origin of marker chromosomes. Thus, genetic counseling and a clear genetic diagnosis of patients with azoospermia before intracytoplasmic sperm injection or other clinical managements are important.

  11. X-ray fluorescence/Auger-electron coincidence spectroscopy of vacancy cascades in atomic argon

    Energy Technology Data Exchange (ETDEWEB)

    Arp, U. [National Inst. of Standards and Technology, Gaithersburg, MD (United States). Electron and Optical Physics Div.; LeBrun, T.; Southworth, S.H.; Jung, M. [Argonne National Lab., IL (United States). Physics Div.; MacDonald, M.A. [E.P.S.R.C. Daresbury Lab., Warrington (United Kingdom)

    1996-12-01

    Argon L{sub 2.3}-M{sub 2.3}M{sub 2.3} Auger-electron spectra were measured in coincidence with K{alpha} fluorescent x-rays in studies of Ar K-shell vacancy decays at several photon energies above the K-threshold and on the 1s-4p resonance in atomic argon. The complex spectra recorded by conventional electron spectroscopy are greatly simplified when recorded in coincidence with fluorescent x-rays, allowing a more detailed analysis of the vacancy cascade process. The resulting coincidence spectra are compared with Hartree-Fock calculations which include shake-up transitions in the resonant case. Small energy shifts of the coincidence electron spectra are attributed to post-collision interaction with 1s photoelectrons.

  12. 35. Detection of numerical chromosome aberrations in sperm of workers exposed to benzene series by two-color fluorescence in situ hybridization

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    To study the frequency of numerical chromosome aberrations in sperm of workers exposed to benzene series, the aneuploidy frequencies of 9 and 18 chromosomes were detected in sperm of workers by two color fluorescence in situ hybridization with digoxingenin labeled 9 chromosome probe (D9zl) and biotin labeled 18 chromosome probe (D18zl). The timeweight average air concentration (TWA ) of benzene in the workplace was 86.49 mg/m3, it was two fold higher than the national maximum allowable concentration. The concentration of urinary trans,trans-muconic acid (ttMA) in exposed group was significantly higher than that of control group. The sperms counted in 14 exposed workers and 16 control workers were 136 401 and 156 955 respectively. The results showed that the disomy frequencies of sperm for chromosome 9, 18 in (0.168%±0.063% and 0.055%±0.031% respectively) and the frequency of diploidy sperm (0.073%±0.045%) were statistically increased over that of the control group(0.050%±0.030%; 0.033%±0.025% and 0.040%±0.036%, respectively). The nullisomic frequencies of 9,18 chromosome in the exposed group (0.206%±0.047%, 0.068%±0.044%) were statistically increased over that of the control group too (0.067%±0.037%, 0.048%±0.034%). The frequency of overall numerical chromosome aberrations in the exposed group was 0.570%±0.144%, when this value was compared with that of control (0.218%±0.071%), a statistically significance was presented. Our experiments showed that exposed to benzene at higher concentration may induce increase in aneuploidy frequency of sperm autosomal chromosome in exposed workers.

  13. Metabolic cytometry: capillary electrophoresis with two-color fluorescence detection for the simultaneous study of two glycosphingolipid metabolic pathways in single primary neurons.

    Science.gov (United States)

    Essaka, David C; Prendergast, Jillian; Keithley, Richard B; Palcic, Monica M; Hindsgaul, Ole; Schnaar, Ronald L; Dovichi, Norman J

    2012-03-20

    Metabolic cytometry is a form of chemical cytometry wherein metabolic cascades are monitored in single cells. We report the first example of metabolic cytometry where two different metabolic pathways are simultaneously monitored. Glycolipid catabolism in primary rat cerebella neurons was probed by incubation with tetramethylrhodamine-labeled GM1 (GM1-TMR). Simultaneously, both catabolism and anabolism were probed by coincubation with BODIPY-FL labeled LacCer (LacCer-BODIPY-FL). In a metabolic cytometry experiment, single cells were incubated with substrate, washed, aspirated into a capillary, and lysed. The components were separated by capillary electrophoresis equipped with a two-spectral channel laser-induced fluorescence detector. One channel monitored fluorescence generated by the metabolic products produced from GM1-TMR and the other monitored the metabolic products produced from LacCer-BODIPY-FL. The metabolic products were identified by comparison with the mobility of a set of standards. The detection system produced at least 6 orders of magnitude dynamic range in each spectral channel with negligible spectral crosstalk. Detection limits were 1 zmol for BODIPY-FL and 500 ymol for tetramethylrhodamine standard solutions.

  14. A physical map of 15 loci on human chromosome 5q23-q33 by two-color fluorescence in situ hybridization

    Energy Technology Data Exchange (ETDEWEB)

    Saltman, D.L.; Dolganov, G.M. (Genelabs Inc. Redwood City, CA (United States)); Warrington, J.A.; Wasmuth, J.J. (Univ. of California, Irvine (United States)); Lovett, M. (Univ. of Texas Southwestern Medical Center, Dallas (United States))

    1993-06-01

    The q23-q33 region of human chromosome 5 encodes a large number of growth factors, growth factor receptors, and hormone/neurotransmitter receptors. This is also the general region into which several disease genes have been mapped, including diastrophic dysplasia, Treacher Collins syndrome, hereditary startle disease, the myeloid disorders that are associated with the 5q-syndrome, autosomal-dominant forms of hereditary deafness, and limb girdle muscular dystrophy. The authors have developed a framework physical map of this region using cosmid clones isolated from the Los Alamos arrayed chromosome 5-specific library. Entry points into this library included 14 probes to genes within this interval and one anonymous polymorphic marker locus. A physical map has been constructed using fluorescence in situ hybridization of these cosmids on metaphase and interphase chromosomes, and this is in good agreement with the radiation hybrid map of the region. The derived order of loci across the region is cen-IL4-IL5-IRF1-IL3-IL9-EGR1-CD14-FGFA-GRL-D5S207-ADRB2-SPARC-RPS14-CSF1R-ADRA1, and the total distance spanned by these loci is approximately 15 Mb. The framework map, genomic clones, and contig expansion within 5q23-q33 should provide valuable resources for the eventual isolation of the clinically relevant loci that reside in this region. 31 refs., 3 figs., 2 tabs.

  15. Two-color infrared detector

    Science.gov (United States)

    Klem, John F; Kim, Jin K

    2014-05-13

    A two-color detector includes a first absorber layer. The first absorber layer exhibits a first valence band energy characterized by a first valence band energy function. A barrier layer adjoins the first absorber layer at a first interface. The barrier layer exhibits a second valence band energy characterized by a second valence band energy function. The barrier layer also adjoins a second absorber layer at a second interface. The second absorber layer exhibits a third valence band energy characterized by a third valence band energy function. The first and second valence band energy functions are substantially functionally or physically continuous at the first interface and the second and third valence band energy functions are substantially functionally or physically continuous at the second interface.

  16. Two-color QCD at high density

    Energy Technology Data Exchange (ETDEWEB)

    Boz, Tamer; Skullerud, Jon-Ivar [Department of Mathematical Physics, Maynooth University, Maynooth, Co. Kildare (Ireland); Centre for the Subatomic Structure of Matter, Adelaide University, Adelaide, SA 5005 (Australia); Giudice, Pietro [Universität Münster, Institut für Theoretische Physik, Münster (Germany); Hands, Simon [Department of Physics, College of Science, Swansea University, Swansea (United Kingdom); Williams, Anthony G. [Centre for the Subatomic Structure of Matter, Adelaide University, Adelaide, SA 5005 (Australia)

    2016-01-22

    QCD at high chemical potential has interesting properties such as deconfinement of quarks. Two-color QCD, which enables numerical simulations on the lattice, constitutes a laboratory to study QCD at high chemical potential. Among the interesting properties of two-color QCD at high density is the diquark condensation, for which we present recent results obtained on a finer lattice compared to previous studies. The quark propagator in two-color QCD at non-zero chemical potential is referred to as the Gor’kov propagator. We express the Gor’kov propagator in terms of form factors and present recent lattice simulation results.

  17. Two-color walking Peregrine solitary waves.

    Science.gov (United States)

    Baronio, Fabio; Chen, Shihua; Mihalache, Dumitru

    2017-09-15

    We study the extreme localization of light, evolving upon a non-zero background, in two-color parametric wave interaction in nonlinear quadratic media. We report the existence of quadratic Peregrine solitary waves, in the presence of significant group-velocity mismatch between the waves (or Poynting vector beam walk-off), in the regime of cascading second-harmonic generation. This finding opens a novel path for the experimental demonstration of extreme rogue waves in ultrafast quadratic nonlinear optics.

  18. Two Color QCD beyond the BEC regime

    CERN Document Server

    Hands, S; Skullerud, J I; Hands, Simon; Kim, Seyong; Skullerud, Jon-Ivar

    2005-01-01

    We present results of simulations of Two Color QCD using two flavors of Wilson quark in the fundamental representation, at non-zero quark chemical potential mu, on an 8^3x16 lattice. Results for the quark number density, quark and gluon energy densities, and superfluid condensate are qualitatively distinct from the behaviour expected on the assumption that the dominant degrees of freedom are tightly bound scalar diquarks which Bose condense; rather the scaling with mu is more suggestive of a Fermi surface disrupted by a Cooper pair condensate. We also present evidence both for screening of the static potential, and color deconfinement, arising solely as a result of a non-zero quark density.

  19. Two-color, double-slit in vivo flow cytometer.

    Science.gov (United States)

    Novak, J; Puoris'haag, M

    2007-10-15

    The in vivo flow cytometer enables the real-time detection and quantification of fluorescent cells circulating within a live animal without the need for incisions or extraction of blood. It has been used in demonstrating flow velocity disparities in biological flows, and in the investigation of the circulation kinetics of various types of cells. However, a shortcoming of this in vivo flow cytometer is that it provides only one excitation slit at one wavelength, resulting in several performance limitations. Therefore, a second in vivo flow cytometer that provides two different laser wavelengths, 473 and 633 nm, and one or two excitation slits has been designed and built. Thus far, the two-color system has been used to acquire circulation kinetics data of two different cell populations each labeled with a different marker, one cell population labeled with two different markers, and one cell population expressing the green-fluorescent protein gene. In addition, accurate arterial red blood cell velocities within a mouse have been determined using the cytometer.

  20. Development of a two-color FQI

    Energy Technology Data Exchange (ETDEWEB)

    Butcher, T.; Wei, G. [Brookhaven National Lab., Upton, NY (United States)

    1996-07-01

    The Flame Quality Indicator (FQI) concept was developed at Brookhaven National Laboratory as a simple device which could be used to monitor oil burner flames and indicate when a problem was starting to occur. Fault situations which could be identified by the FQI include: fouled nozzle, increased or decreased excess air, blocked air inlet or flue, and use of low quality oil. The basic concept of the FQI is quite simple. A conventional cadmium sulfide photocell is used to measure the amount of light emitted from an oil burner flame when the appliance is fully warmed-up. The measured amount of light is compared to a set point, established during burner tune-up. If the two intensities differ by more than a set range, a {open_quotes}service required{close_quotes} signal is produced. The amount of light which is emitted from an oil burner flame depends upon the amount of {open_quotes}soot{close_quotes} or carbon in the flame, the size and shape of the flame, and the flame temperature. The quality of flame is practically judged by the amount of soot which it is producing and for this reason it is necessary to eliminate effects of other parameters. Temperature is expected to be the most important of these. The FQI eliminates effects due to the chamber environment by establishing a set point for each specific appliance. The transient temperature effects are accounted for by examining the flame brightness only at a single time during the firing cycle. BNL is currently involved with the development of a two-color approach to the monitoring of flame quality. The basic concept involved is the measurement of both flame temperature and total amount of light emitted to allow a more direct estimate to be made of the amount of soot being produced and so the flame quality. The objective is to develop a more sensitive measurement which may be more universally applicable. This paper provides a summary of our approach and results to date in this project.

  1. The study of two-color excitation upconversion of Pr(0.5)Yb(3):ZBLAN

    Institute of Scientific and Technical Information of China (English)

    CHEN; Xiaobo; SONG; Zengfu

    2006-01-01

    The excited state absorption upconversion of Pr(0.5)Yb(3):ZBLAN glass material, under two-color excitation of the 960 nm semiconductor laser and the Xe lamp light simultaneously, is reported in this article. It was found that the upconversion emission spectra of 480.1, 519.0, 601.9 and 631.8 nm coincide with the common emission spectra. Meanwhile, the upconversion-excitation spectrum has three obvious peaks under two-color excitation, and they respectively correspond to the 856.0 nm upconversion excitation transition [1G4(Pr3+)→1I6(Pr3+) and 1G4(Pr3+)→3P1(Pr3+)], the 789.0 nm upconversion excitation transition 1G4(Pr3+)→3P2(Pr3+), and the 803.7 nm upconversion excitation transition 3H6(Pr3+)→1D2(Pr3+). The upconversion excitation transition 1G4(Pr3+)→1I6(Pr3+) is strong because its oscillator strength f = 23.040(10-6 is large, which results in a large peak appearing in the upconversion excitation spectrum. That is just the new interesting two-color excitation upconversion luminescence phenomenon of Pr(0.5)Yb(3):ZBLAN induced by one laser and one continuous normal light simultaneously.

  2. APPLICATION OF TWO-COLOR INTERPHASE FISH USING SEX PROBE IN ALLOGENEIC STEM CELL TRANSPLANTATION

    Institute of Scientific and Technical Information of China (English)

    曾慧兰; 李建勇; 朱康儿; 薛永权; 李杨秋; 刘晓力; 过宇

    2002-01-01

    Objective: To evaluate the significance of two-color interphase fluorescence in situ hybridization (FISH) using X and Y centromere probe in the engraftment estimation and minimal residual disease (MRD) monitoring after allogeneic stem cell transplantation (alloSCT). Methods: Samples from 12 cases patients in different periods after alloSCT were detected by interphase FISH. Results: All of the 12 patients were proved to obtain engraftment 22(35 days after alloSCT. While traditional karyotype showed as 100%XX or 100%XY invariably, FISH showed different percentages of donor original sex chromosome. Conclusion: Two-color interphase FISH is a more sensitive and simple test for engraftment evaluation and MRD monitoring post SCT, though, it can not entirely replace traditional karyotype analysis and gene detection by RT-PCR.

  3. Combining Digital Watermarks with Two-Color Bitmap Image

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A technology for combining digital watermarks with two-color bitmap image based on the threshold watermarking method is presented. Our technology doesn't add any thing to the digital media, but combines the watermarks in two-color bitmap image by looking for some characteristic values in the bitmap and uses the relationship between the watermarks and the characteristic values to prove the copyright protection. The choice of the characteristic values depends on the choice of a cryptographic key known by the owner of the bitmap. The benefit of using a cryptographic key is to combine the watermarks with the bitmap in a high secure way.

  4. Rational choices for the wavelengths of a two color interferometer

    Energy Technology Data Exchange (ETDEWEB)

    Jobes, F.C.

    1995-07-01

    If in a two color interferometer for plasma density measurements, the two wavelengths are chosen to have a ratio that is a rational number, and if the signals from each of the wavelengths are multiplied in frequency by the appropriate integer of the rational number and then heterodyned together, the resultant signal will have all effects of component motion nulled out. A phase measurement of this signal will have only plasma density information in it. With CO{sub 2} lasers, it is possible to find suitable wavelength pairs which are close enough to rational numbers to produce an improvement of about 100 in density resolution, compared to standard two color interferometers.

  5. Two-color beam generation based on wakefield excitation

    Science.gov (United States)

    Bettoni, S.; Prat, E.; Reiche, S.

    2016-05-01

    Several beam manipulation methods have been studied and experimentally tested to generate two-color photon beams in free electron laser facilities to accommodate the user requests. We propose to use the interaction of the beam with an oscillating longitudinal wakefield source to obtain a suitable electron beam structure. The bunch generates two subpulses with different energies and delayed in time passing through a magnetic chicane after its longitudinal phase space has been modulated by the wakefield source. According to this approach the power of the emitted radiation is not degraded compared to the monochromatic beam, and the setup in the machine is quite simple because the bunch is manipulated only in the high energy section, where it is more rigid. We present the design applied to SwissFEL. We identified the parameters and the corresponding range of tunability of the time and energy separation among the two subbunches.

  6. Fabrication of optical multilayer for two-color phase plate in super-resolution microscope.

    Science.gov (United States)

    Iketaki, Yoshinori; Kitagawa, Katsuichi; Hidaka, Kohjiro; Kato, Naoki; Hirabayashi, Akira; Bokor, Nandor

    2014-07-01

    In super-resolution microscopy based on fluorescence depletion, the two-color phase plate (TPP) is an indispensable optical element, which can independently control the phase shifts for two beams of different color, i.e., the pump and erase beams. By controlling a phase shift of the erase beam through the TPP, the erase beam can be modulated into a doughnut shape, while the pump beam maintains the initial Gaussian shape. To obtain a reliable optical multiplayer (ML) for the TPP, we designed a ML with only two optical layers by performing numerical optimization. The measured phase shifts generated by the fabricated ML using interferometry correspond to the design values. The beam profiles in the focal plane are also consistent with theoretical results. Although the fabricated ML consists of only two optical layers, the ML can provide a suitable phase modulation function for the TPP in a practical super-resolution microscope.

  7. Two-color in vivo imaging of photoreceptor apoptosis and development in Drosophila.

    Science.gov (United States)

    Gambis, Alexis; Dourlen, Pierre; Steller, Hermann; Mollereau, Bertrand

    2011-03-01

    We report a new two-color fluorescent imaging system to visualize the mosaic adult photoreceptor neurons (PRs) in real-time. Using this method, we examined a collection of 434 mutants and identified genes required for PR survival, planar cell polarity (PCP), patterning and differentiation. We could track the progression of PR degeneration in living flies. By introducing the expression of p35, a caspase inhibitor, we found mutations that specifically activate caspase-dependent death. Moreover, we showed that grh is required in R3 for correct PCP establishment. The "Tomato/GFP-FLP/FRT" method allows high-throughput, rapid and precise identification of survival and developmental pathways in living adult PRs at single-cell resolution.

  8. Two-color temporal focusing multiphoton excitation imaging with tunable-wavelength excitation

    Science.gov (United States)

    Lien, Chi-Hsiang; Abrigo, Gerald; Chen, Pei-Hsuan; Chien, Fan-Ching

    2017-02-01

    Wavelength tunable temporal focusing multiphoton excitation microscopy (TFMPEM) is conducted to visualize optical sectioning images of multiple fluorophore-labeled specimens through the optimal two-photon excitation (TPE) of each type of fluorophore. The tunable range of excitation wavelength was determined by the groove density of the grating, the diffraction angle, the focal length of lenses, and the shifting distance of the first lens in the beam expander. Based on a consideration of the trade-off between the tunable-wavelength range and axial resolution of temporal focusing multiphoton excitation imaging, the presented system demonstrated a tunable-wavelength range from 770 to 920 nm using a diffraction grating with groove density of 830 lines/mm. TPE fluorescence imaging examination of a fluorescent thin film indicated that the width of the axial confined excitation was 3.0±0.7 μm and the shifting distance of the temporal focal plane was less than 0.95 μm within the presented wavelength tunable range. Fast different wavelength excitation and three-dimensionally rendered imaging of Hela cell mitochondria and cytoskeletons and mouse muscle fibers were demonstrated. Significantly, the proposed system can improve the quality of two-color TFMPEM images through different excitation wavelengths to obtain higher-quality fluorescent signals in multiple-fluorophore measurements.

  9. Two-color lattice QCD with staggered quarks

    Energy Technology Data Exchange (ETDEWEB)

    Scheffler, David

    2015-07-20

    The study of quantum chromodynamics (QCD) at finite temperature and density provides important contributions to the understanding of strong-interaction matter as it is present e.g. in nuclear matter and in neutron stars or as produced in heavy-ion collision experiments. Lattice QCD is a non-perturbative approach, where equations of motion for quarks and gluons are discretized on a finite space-time lattice. The method successfully describes the behavior of QCD in the vacuum and at finite temperature, however it cannot be applied to finite baryon density due to the fermion sign problem. Various QCD-like theories, that offer to draw conclusions about QCD, allow simulations also at finite densities. In this work we investigate two-color QCD as a popular example of a QCD-like theory free from the sign problem with methods from lattice gauge theory. For the generation of gauge configurations with two dynamical quark flavors in the staggered formalism with the ''rooting trick'' we apply the Rational Hybrid Monte Carlo (RHMC) algorithm. We carry out essential preparatory work for future simulations at finite density. As a start, we concentrate on the calculation of the effective potential for the Polyakov loop, which is an order parameter for the confinement-deconfinement transition, in dependence of the temperature and quark mass. It serves as an important input for effective models of QCD. We obtain the effective potential via the histogram method from local distributions of the Polyakov loop. To study the influence of dynamical quarks on gluonic observables, the simulations are performed with large quark masses and are compared to calculations in the pure gauge theory. In the second part of the thesis we examine aspects of the chiral phase transition along the temperature axis. The symmetry group of chiral symmetry in two-color QCD is enlarged to SU(2N{sub f}). Discretized two-color QCD in the staggered formalism exhibits a chiral symmetry breaking

  10. Noise in two-color electronic distance meter measurements revisited

    Science.gov (United States)

    Langbein, J.

    2004-01-01

    Frequent, high-precision geodetic data have temporally correlated errors. Temporal correlations directly affect both the estimate of rate and its standard error; the rate of deformation is a key product from geodetic measurements made in tectonically active areas. Various models of temporally correlated errors are developed and these provide relations between the power spectral density and the data covariance matrix. These relations are applied to two-color electronic distance meter (EDM) measurements made frequently in California over the past 15-20 years. Previous analysis indicated that these data have significant random walk error. Analysis using the noise models developed here indicates that the random walk model is valid for about 30% of the data. A second 30% of the data can be better modeled with power law noise with a spectral index between 1 and 2, while another 30% of the data can be modeled with a combination of band-pass-filtered plus random walk noise. The remaining 10% of the data can be best modeled as a combination of band-pass-filtered plus power law noise. This band-pass-filtered noise is a product of an annual cycle that leaks into adjacent frequency bands. For time spans of more than 1 year these more complex noise models indicate that the precision in rate estimates is better than that inferred by just the simpler, random walk model of noise.

  11. Towards the phase diagram of dense two-color matter

    CERN Document Server

    Cotter, Seamus; Hands, Simon; Skullerud, Jon-Ivar

    2012-01-01

    We study two-color QCD with two flavors of Wilson fermion as a function of quark chemical potential mu and temperature T. We find evidence of a superfluid phase at intermediate mu and low T where the quark number density and diquark condensate are both very well described by a Fermi sphere of nearly-free quarks disrupted by a BCS condensate. Our results suggest that the quark contribution to the energy density is negative (and balanced by a positive gauge contribution), although this result is highly sensitive to details of the energy renormalisation. We also find evidence that the chiral condensate in this region vanishes in the massless limit. This region gives way to a region of deconfined quark matter at higher T and mu, with the deconfinement temperature, determined from the renormalised Polyakov loop, decreasing only very slowly with increasing chemical potential. The quark number susceptibility chi_q does not exhibit any qualitative change at the deconfinement transition. We argue that this is because ...

  12. Development of a novel two color tracer perfusion technique for the hydrodynamic study of aqueous outflow in bovine eyes

    Institute of Scientific and Technical Information of China (English)

    ZHU Jing-yin; YE Wen; GONG Hai-yan

    2010-01-01

    Background Elevation of intraocular pressure is usually associated with primary open angle glaucoma and caused by increased outflow resistance. A two-color fluorescent tracer technique was developed to investigate the hydrodynamics of aqueous humor outflow with changing intraocular pressure within the same eye, to better understand the relationship between outflow facility and effective filtration area. Methods Eighteen enucleated bovine eyes were first perfused at 30 mmHg with Dulbecco's phosphate-buffered saline containing 5.5 mmol/L D-glucose. After a stable baseline facility, red fluorescent microspheres (0.5 μm, 0.002% v/v) were exchanged and perfused. Eyes in the one-color control group (n=6) were immediately perfused with fixative. In the experimental group (n=6), eyes were perfused with green tracer after intraocular pressure reduced to 7 mmHg, while in the two-color control group (n=6), eyes were perfused with green tracer with intraocular pressure remaining at 30 mmHg. All 12 eyes were then perfusion-fixed. Outflow facility was continuously recorded in all eyes. Confocal images were taken along the inner wall of the aqueous plexus and the percent of the effective filtration length (PEFL; length of inner wall exhibiting tracer labeling/total length of inner wall) was measured. The relationships between outflow facility and PEFL were analyzed statistically. Results No significant differences were found in baseline facilities (ulmin~(-1)·mmHg~(-1)) among the three groups (the experimental group: 0.93 0.12; the two-color control group: 0.90 0.19; the one-color control group: 0.98 0.13). In the experimental group, the outflow facility was significantly higher at 7 mmHg (4.29±1.01) than that at 30 mmHg (1.90±0.67, P <0.001), which corresponded to a significant increase in the PEFL at 7 mmHg (54.70±8.42) from that at 30 mmHg ((11.76±4.56)%, P<0.001). The PEFL labeled by red fluorescent microspheres in the experimental group ((11.76±4.56)%) showed no

  13. On Two Color and CCD Methods for the Determination of Astronomic Position.

    Science.gov (United States)

    1986-03-14

    INTRODUCTION .................................... 2 A. Astroposition Objectives As Related to Two-Color Refractometry .................. 2 B. Results...value for the astronomic longitude and latitude.-_ A. Astroposition Objectives As Related to Two-Color Refractometry The long term objectives consist...The interior of the box was divided into 4 bays containing the telescope, the refractometry optics, the power supplies and the refralctometry

  14. Coincidence Auger spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Penent, F. [LCPMR, Universite Pierre et Marie Curie, 75231 Paris 5 (France) and DIAM, Universite Pierre et Marie Curie, 75252 Paris 5 (France)]. E-mail: penent@ccr.jussieu.fr; Lablanquie, P. [LURE, Universite Paris Sud, 91898 Orsay (France); Hall, R.I. [DIAM, Universite Pierre et Marie Curie, 75252 Paris 5 (France); Palaudoux, J. [LCPMR, Universite Pierre et Marie Curie, 75231 Paris 5 (France); Ito, K. [Photon Factory, IMSS, KEK, Tsukuba 305-0801 (Japan); Hikosaka, Y. [Photon Factory, IMSS, KEK, Tsukuba 305-0801 (Japan); IMS, Okazaki 444-8585 (Japan); Aoto, T. [Photon Factory, IMSS, KEK, Tsukuba 305-0801 (Japan); Eland, J.H.D. [Physical and Theoretical Chemistry Laboratory, South Parks Road, Oxford OX1 3DW (United Kingdom)

    2005-06-15

    Auger electron spectroscopy (AES) and photoelectron spectroscopy (PES) are (with X-ray emission spectroscopy, XES) powerful analytical tools for material science and gas phase studies. However, the interpretation of Auger spectra can be very difficult due to the number and complexity of the involved processes. A deeper analysis, that allows a better understanding of relaxation processes following inner shell ionization, is possible with coincidence Auger spectroscopy. This method gives a new insight into electron correlation and allows disentangling of complex Auger electron spectra. In this paper, we present some examples related to gas phase coincidence Auger electron spectroscopy using synchrotron radiation. The detection in coincidence of an Auger electron with a threshold photoelectron presents two main advantages which are good energy resolution and high coincidence count rates. This technique has also provided new results on double Auger decay processes. A further qualitative breakthrough has been made with the development of a new experimental set-up based on a magnetic bottle time-of-flight electron spectrometer. This opens up the field of multi-electron coincidence spectroscopy and allows a most detailed analysis with characterization of all possible decay pathways following inner shell ionization.

  15. Development of two color laser diagnostics for the ITER poloidal polarimeter.

    Science.gov (United States)

    Kawahata, K; Akiyama, T; Tanaka, K; Nakayama, K; Okajima, S

    2010-10-01

    Two color laser diagnostics using terahertz laser sources are under development for a high performance operation of the Large Helical Device and for future fusion devices such as ITER. So far, we have achieved high power laser oscillation lines simultaneously oscillating at 57.2 and 47.7 μm by using a twin optically pumped CH(3)OD laser, and confirmed the original function, compensation of mechanical vibration, of the two color laser interferometer. In this article, application of the two color laser diagnostics to the ITER poloidal polarimeter and recent hardware developments will be described.

  16. In situ spatial mapping of Gouy phase slip with terahertz generation in two-color field.

    Science.gov (United States)

    Meng, Chao; Lü, Zhihui; Huang, Yindong; Wang, Xiaowei; Chen, Wenbo; Zhang, Dongwen; Zhao, Zengxiu; Yuan, Jianmin

    2016-05-30

    We establish a one-to-one mapping between the local phase slip and the spatial position near the focus by scanning a thin jet along the propagation direction of laser beams. The measurement shows that the optimal phase of terahertz can be utilized to characterize in situ the spatially dependent relative phase of the two-color field. We also investigate the role of the Gouy phase shift on terahertz generation from two-color laser-induced plasma. The result is of critical importance for phase-dependent applications of two-color laser-field, including high-order harmonic and terahertz generation.

  17. Coincidence studies with antiprotons

    Energy Technology Data Exchange (ETDEWEB)

    McGovern, M; Walters, H R J [Department of Applied Mathematics and Theoretical Physics, Queen' s University, Belfast BT7 1NN (United Kingdom); Assafrao, D; Mohallem, J R [Laboratorio de Atomos e Moleculas Especiais, Departamento de Fisica, ICEx, Universidade Federal de Minas Gerais, P.O Box 702, 30123-970 Belo Horizonte, MG (Brazil); Whelan, Colm T, E-mail: mmcgovern06@qub.ac.u [Department of Physics, Old Dominion University, Norfolk, VA 23529-0116 (United States)

    2010-02-01

    We present a short overview of a new method for calculating fully differential cross sections that is able to describe any aspect of coincidence measurements involving heavy projectiles. The method is based upon impact parameter close coupling with pseudostates. Examples from antiproton impact ionization are shown.

  18. Maternal detection of neonatal jaundice during birth hospitalization using a novel two-color icterometer

    National Research Council Canada - National Science Library

    Bolajoko O Olusanya; Tina M Slusher; Donald O Imosemi; Abieyuwa A Emokpae

    2017-01-01

    .... This study therefore, set out to evaluate the performance of a -two-color icterometer (BilistripTM) as a possible screening tool for detecting significant jaundice by mothers or care-givers in the first week of life...

  19. Fabrication of two-color annular hybrid wave plate for three-dimensional super-resolution microscopy

    Science.gov (United States)

    Kumagai, Hiroshi; Iketaki, Yoshinori; Jahn, Kornel; Bokor, Nador

    2016-03-01

    In super-resolution microscopy, we use fluorescence depletion, where an erase beam quenches a molecule in the S1 state generated by a pump beam, and then prevents fluorescence from the S1 state. When a tight doughnut shaped erase beam with is focused on the dyed sample together with a Gaussian pump beam, the remaining fluorescence spot in the focal plane becomes smaller than the diffraction-limited size. Applying destructive interference to the erase beam, erase beam has a minute three-dimensional dark spot surrounded by the light near the focal region. Since this spot introduces fluorescence depletion along the optical axis as in the focal plane, we can achieve three-dimensional super-resolution microscopy. However, to overcome the diffraction limit, an extremely precise optical alignment is required for projecting the focused pump beam into the dark spot of the erase beam. To resolve this technical issue, we fabricated a two-color annular hybrid wave plate (TAHWP) by combining two multi-order wave quartz plates. Although the pump and erase beams co-axially pass through the plate; the pump beam retains its original Gaussian shape, while the erase beam undergoes destructive interference. Inserting the TAHWP into a commercial scanning laser microscope, a three-dimensional spherical fluorescence spot with a volume of (~100 nm)3 can be created. Beside eliminating alignment problems and yielding a compact setup, the TAHWP makes our proposed method very suitable for commercial microscope systems. In this study, we report about detailed fabrication procedure and three-dimensional image properties given by the TAHWP.

  20. Two-Color Magneto-Optical Trap with Small Magnetic Field for Ytterbium

    CERN Document Server

    Kawasaki, Akio; Yu, QinQin; Vuletić, Vladan

    2015-01-01

    We report a two-color magneto-optical trap (MOT) for ytterbium atoms operating at a low magnetic field gradient down to 2 G/cm where a conventional MOT using the singlet transition (6s^2 1S0 -> 6s6p 1P1) is unable to trap atoms. By simultaneously applying laser light on both the broad-linewidth singlet transition and the narrow-linewidth triplet transition (6s^2 1S0 -> 6s6p 3P1), we load and trap 4.0 x 10^5 atoms directly from an atomic beam at 700 K. In the two-color MOT, the slowing and trapping functions are separately performed by the singlet transition light and the triplet transition light, respectively. The two-color MOT is highly robust against laser power imbalance even at very low magnetic field gradients.

  1. Inkjet printing the three organic functional layers of two-colored organic light emitting diodes

    Energy Technology Data Exchange (ETDEWEB)

    Coenen, Michiel J.J., E-mail: Michiel.Coenen@tmc.nl [Holst Centre, PO BOX 8550, 5605 KN Eindhoven (Netherlands); Slaats, Thijs M.W.L.; Eggenhuisen, Tamara M. [Holst Centre, PO BOX 8550, 5605 KN Eindhoven (Netherlands); Groen, Pim [Holst Centre, PO BOX 8550, 5605 KN Eindhoven (Netherlands); Novel Aerospace Materials Group, Faculty of Aerospace Engineering, Delft University of Technology, Kluyverweg 1, 2629HS Delft (Netherlands)

    2015-05-29

    Inkjet printing allows for the roll-2-roll fabrication of organic electronic devices at an industrial scale. In this paper we demonstrate the fabrication of two-colored organic light emitting diodes (OLEDs) in which three adjacent organic device layers were inkjet printed from halogen free inks. The resulting devices demonstrate the possibilities offered by this technique for the fabrication of OLEDs for signage and personalized electronics. - Highlights: • Two-colored organic light emitting diodes with 3 inkjet printed device layers were fabricated. • All materials were printed from halogen free inks. • Inkjet printing of emissive materials is suitable for signage applications.

  2. Electron Correlation in Nonsequential Double Ionization of Helium by Two-Color Pulses

    Institute of Scientific and Technical Information of China (English)

    ZHOU Yue-Ming; LIAO Qing; HUANG Cheng; TONG Ai-Hong; LU Pei-Xiang

    2010-01-01

    @@ We investigate the momentum and energy correlations between the two electrons from nonsequential double ionization(NSDI)of helium by strong two-color pulses with the classical three-dimensional ensemble model.The correlated momentum distribution in the direction parallel to the laser field exhibits an arc-like structure and the sum-energy spectrum shows a sharp peak for the NSDI of helium in the two-color fields.Back analysis reveals that the narrow time interval during which recollisions occur,the low returning energy and the short time delay between recollision and double ionization lead to the novel momentum and energy correlations.

  3. Long-range predissociation in two-color photoassociation of ultracold Na atoms

    NARCIS (Netherlands)

    Molenaar, P.A.; Straten, P. van der; Heideman, H.G.M.

    1997-01-01

    We report two-color photo-associative ionization of sodium in a Magneto-Optical Trap. The experimental results yield information on both singly and doubly excited states. We find that the highest bound vibrational levels (v > 20) of the singly-excited 0^- g state predissociate into the 3²P3/2

  4. Streaking temporal double slit interference by an orthogonal two-color laser field

    CERN Document Server

    Richter, Martin; Schöffler, Markus; Jahnke, Till; Schmidt, Lothar P H; Li, Min; Liu, Yunquan; Dörner, Reinhard

    2015-01-01

    We investigate electron momentum distributions from single ionization of Ar by two orthogonally polarized laser pulses of different color. The two-color scheme is used to experimentally control the interference between electron wave packets released at different times within one laser cycle. This intracycle interference pattern is typically hard to resolve in an experiment. With the two-color control scheme these features become the dominant contribution to the electron momentum distribution. Furthermore the second color can be used for streaking of the otherwise interfering wave packets establishing a which-way marker. Our investigation shows that the visibility of the interference fringes depends on the degree of the which-way information determined by the controllable phase between the two pulses.

  5. Effects of a static electric field on two-color photoassociation of heteronuclear atom-pairs

    CERN Document Server

    Chakraborty, Debashree

    2013-01-01

    We study non-perturbative effects of a static electric field on two-color photoassociation of heteronuclear atom-pairs. A static electric field induces anisotropy in scattering between two heteronuclear atoms and hybridizes field-free rotational states of heteronuclear dimers or polar molecules. In a previous paper [D. Chakraborty $\\it {et.}$ $\\it {al.}$, J. Phys. B 44, 095201 (2011)], the effects of a static electric field on one-color photoassociation between heteronuclear atoms has been described through field-modified ground-state scattering states, neglecting electric field effects on heteronuclear diatomic bound states. To study the effects of a static electric field on heteronuclear bound states, and the resulting influence on Raman-type two-color photoassociation between heteronuclear atoms in the presence of a static electric field, we develop a non-perturbative numerical method to calculate static electric field-dressed heteronuclear bound states. We show that the static electric field induced scatt...

  6. Femtosecond Non-degenerate Four Wave Mixing Spectroscopy: The Two Color Photon Echo Peak Shift

    CERN Document Server

    Prall, B S

    2005-01-01

    The couplings between multiple electronic states and electronic and nuclear coordinates are examined for condensed phase systems by femtosecond degenerate and non-degenerate four wave mixing. The two-color photon echo peak shift experiment is developed which allows measurement of the correlation between transition frequencies in two different spectral regions. Two-color photon echo peak shift (2C3PEPS) experiments are used to study coupling between electronic states in the lutetium bisphthalocyanine anion, LuPc2−. Electronically induced mixing between exciton and charge resonance states leads to correlations in transition energies for the two observed transitions. This correlation generates non-zero 2C3PEPS which, when compared with 1C3PEPS, allows experimental determination of the degree of mixing, which was in good agreement with theoretical predictions. By exploiting a coherently excited nuclear wavepacket, the nuclear dependence on the electronic mixing between exciton and charge resonance state...

  7. Two-color mid-infrared thermometer with a hollow glass optical fiber.

    Science.gov (United States)

    Small, W; Celliers, P M; Da Silva, L B; Matthews, D L; Soltz, B A

    1998-10-01

    We have developed a low-temperature optical-fiber-based two-color infrared thermometer. A single 700-mum-bore hollow glass optical fiber collects and transmits radiation that is then modulated and split into two paths by a reflective optical chopper. Two different thermoelectrically cooled mid-infrared HgCdZnTe photoconductors monitor the chopped signals that are recovered with lock-in amplification. With the two previously obtained blackbody calibration equations, a computer algorithm calculates the true temperature and emissivity of a target in real time, taking into account reflection of the ambient radiation field from the target surface. The small numerical aperture of the hollow glass fiber and the fast response of the detectors, together with the two-color principle, permit high spatial and temporal resolution while allowing the user to dynamically alter the fiber-to-target distance.

  8. Low-temperature characteristics of two-color InAs/InP quantum dots laser

    Institute of Scientific and Technical Information of China (English)

    Shiguo Li; Qian Gong; Xinzhong Wang; Li Yue; Oingbo Liu; Hailong Wang

    2012-01-01

    We report on the lasing characteristics of a two-color InAs/InP quantum dots (QDs) laser at a low temperature.Two lasing peaks with a tunable gap are simultaneously observed.At a low temperature of 80 K,a tunable range greater than a 20-nm wavelength is demonstrated by varying the injection current from 30 to 500 mA.Under a special condition,we even observe three lasing peaks,which are in contrast to those observed at room temperature.The temperature coefficient of the lasing wavelength was obtained for the two colors in the 80-280 K temperature range,which is lower than that of the reference quantum well (QW) laser working in the same wavelength region.

  9. Dirac Spectrum of the Wilson Dirac Operator for QCD with Two Colors

    CERN Document Server

    Kieburg, Mario; Zafeiropoulos, Savvas

    2015-01-01

    We study the lattice artefacts of the Wilson Dirac operator for QCD with two colors and fermions in the fundamental representation from the viewpoint of chiral perturbation theory. These effects are studied with the help of the following spectral observables: the level density of the Hermitian Wilson Dirac operator, the distribution of chirality over the real eigenvalues, and the chiral condensate for the quenched as well as for the unquenched theory. We provide analytical expressions for all these quantities. Moreover we derive constraints for the level density of the real eigenvalues of the non-Hermitian Wilson Dirac operator and the number of additional real modes. The latter is a good measure for the strength of lattice artefacts. All computations are confirmed by Monte Carlo simulations of the corresponding random matrix theory which agrees with chiral perturbation theory of two color QCD with Wilson fermions.

  10. Autler-Townes splitting in two-color photoassociation of 6Li

    CERN Document Server

    Schloeder, U; Silber, C; Zimmermann, C; Schloeder, Ulrike; Deuschle, Thomas; Silber, Christian; Zimmermann, Claus

    2003-01-01

    We report on high-resolution two-color photoassociation spectroscopy in the triplet system of magneto-optically trapped 6Li. The absolute transition frequencies have been measured. Strong optical coupling of the bound molecular states has been observed as Autler-Townes splitting in the photoassociation signal. The spontaneous bound-bound transition rate is determined and the molecule formation rate is estimated. The observed lineshapes are in good agreement with the theoretical model.

  11. Lowest eigenvalues of the Dirac operator for two color QCD at finite density

    CERN Document Server

    Bittner, E; Markum, H; Pullirsch, R; Bittner, Elmar; Lombardo, Maria-Paola; Markum, Harald; Pullirsch, Rainer

    2001-01-01

    We investigate the eigenvalue spectrum of the staggered Dirac matrix in full QCD with two colors and finite chemical potential. Along the strong-coupling axis up to the temperature phase transition, the low-lying Dirac spectrum is well described by random matrix theory (RMT) and exhibits universal behavior. The situation is discussed in the chirally symmetric phase and no universality is seen for the microscopic spectral density.

  12. Polyakov-Quark-Meson-Diquark Model for two-color QCD

    CERN Document Server

    Strodthoff, Nils

    2013-01-01

    We present an update on the phase diagram of two-color QCD from a chiral effective model approach based on a quark-meson-diquark model using the Functional Renormalization Group (FRG). We discuss the impact of perturbative UV contributions, the inclusion of gauge field dynamics via a phenomenological Polyakov loop potential, and the impact of matter backcoupling on the gauge sector. The corresponding phase diagram including these effects is found to be in qualitative agreement with recent lattice investigations.

  13. Nonvolatile two-color holographic recording in near-stoichiometric lithium niobate crystals gated by incoherent ultraviolet light

    Institute of Scientific and Technical Information of China (English)

    Shaolin Chen; Xiangming Liu; Bo Fu; Guoquan Zhang

    2009-01-01

    Nonvolatile two-color holographic recording gated by incoherent ultraviolet (UV) light centered at 365 nm is investigated in near-stoichiometric lithium niobate crystals. The influence of thermal treatment on the two-color recording is studied. The results show that thermal reduction tends to improve the two-color recording performance, whereas thermal oxidation degrades the two-color recording. With an incoherent 0.2-W/cm2 UV gating light and a 0.25-W/cm2 semiconductor recording laser at 780 nm, a two-color recording sensitivity of 4 x 10-3 cm/J and a recording dynamic range characterized by M/# of 0.12 are achieved in a 2.2-mm thermally reduced near-stoichiometric lithium niobate crystal. We attribute the improvement to the prolonged lifetime of small polarons and the increased absorption at the gating wavelength due to thermal reduction.

  14. Assessing probe-specific dye and slide biases in two-color microarray data

    Directory of Open Access Journals (Sweden)

    Goldberg Zelanna

    2008-07-01

    Full Text Available Abstract Background A primary reason for using two-color microarrays is that the use of two samples labeled with different dyes on the same slide, that bind to probes on the same spot, is supposed to adjust for many factors that introduce noise and errors into the analysis. Most users assume that any differences between the dyes can be adjusted out by standard methods of normalization, so that measures such as log ratios on the same slide are reliable measures of comparative expression. However, even after the normalization, there are still probe specific dye and slide variation among the data. We define a method to quantify the amount of the dye-by-probe and slide-by-probe interaction. This serves as a diagnostic, both visual and numeric, of the existence of probe-specific dye bias. We show how this improved the performance of two-color array analysis for arrays for genomic analysis of biological samples ranging from rice to human tissue. Results We develop a procedure for quantifying the extent of probe-specific dye and slide bias in two-color microarrays. The primary output is a graphical diagnostic of the extent of the bias which called ECDF (Empirical Cumulative Distribution Function, though numerical results are also obtained. Conclusion We show that the dye and slide biases were high for human and rice genomic arrays in two gene expression facilities, even after the standard intensity-based normalization, and describe how this diagnostic allowed the problems causing the probe-specific bias to be addressed, and resulted in important improvements in performance. The R package LMGene which contains the method described in this paper has been available to download from Bioconductor.

  15. Two-color CO{sub 2}/HeNe laser interferometer for C-2 experiment

    Energy Technology Data Exchange (ETDEWEB)

    Gornostaeva, O.; Deng, B. H.; Garate, E.; Gota, H.; Kinley, J.; Schroeder, J.; Tuszewski, M. [Tri Alpha Energy, Inc., P.O. Box 7010, Rancho Santa Margarita, California 92688 (United States)

    2010-10-15

    A six-channel two-color interferometer has been developed for plasma electron density measurements in the C-2 field reversed configuration experiment. A CO{sub 2} laser is utilized as the main probe beams, while copropagating visible HeNe laser beams are mainly sensitive to vibration. Density measurements in C-2 plasmas have shown that this is a reliable turn-key system. The maximum residual phase noise after vibration compensation is less than {+-}5 deg., corresponding to a line integral density of 3x10{sup 18} m{sup -2}. The time resolution for routine operation is 2 {mu}s.

  16. Control of the polarization of attosecond pulses using a two-color field

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz, Camilo; Hoffmann, David J; Torres, Ricardo; Chipperfield, Luke E; Marangos, Jonathan P [Blackett Laboratory, Imperial College London, London SW7 2BW (United Kingdom)], E-mail: camilo@usal.es

    2009-11-15

    Control over the polarization of an attosecond pulse train (APT) is demonstrated theoretically using orthogonally polarized two-color fields. The carrier envelope phase of the two pulses is used as a control parameter to generate both an APT with linear polarization in two nearly perpendicular planes or a train of elliptically polarized pulses of alternating helicity. By using few-cycle driving laser fields an isolated attosecond pulse with elliptical polarization is shown to be generated after selecting the cut-off region of the harmonic spectrum. The control mechanism is explained in terms of classical trajectories.

  17. Tomographic imaging of asymmetric molecular orbitals with a two-color multicycle laser field

    CERN Document Server

    Qin, Meiyan; Zhang, Qingbin; Lu, Peixiang

    2013-01-01

    We theoretically demonstrate a scheme for tomographic reconstruction of asymmetric molecular orbitals based on high-order harmonic generation with a two-color multicycle laser field. It is shown that by adjusting the relative phase of the two fields, the returning electrons can be forced to recollide from one direction for all the orientations of molecules. Thus the reconstruction of the asymmetric orbitals can be carried out with multicycle laser field. This releases the stringent requirement of a single-cycle pulse with a stabilized and controllable carrier-envelop phase for the tomographic imaging of asymmetric molecular orbitals.

  18. Two-Color Fabry-Perot Laser Diode with THz Primary Mode Spacing

    CERN Document Server

    O'Brien, S; Buckley, K; Fehse, R; Amann, A; O'Reilly, E P; Barry, L P; Anandarajah, P; Patchell, J; O'Gorman, J

    2006-01-01

    A class of multiwavelength Fabry-Perot lasers is introduced where the spectrum is tailored through a non-periodic patterning of the cavity effective index. The cavity geometry is obtained using an inverse scattering approach and can be designed such that the spacing of discrete Fabry-Perot lasing modes is limited only by the bandwidth of the inverted gain medium. A specific two-color semiconductor laser with a mode spacing in the THz regime is designed, and measurements are presented demonstrating the simultaneous oscillation of the two wavelengths. The extension of the Fabry-Perot laser concept described presents significant new possibilities in laser cavity design.

  19. Two-color QCD with non-zero chiral chemical potential

    Energy Technology Data Exchange (ETDEWEB)

    Braguta, V.V. [Institute for High Energy Physics NRC “Kurchatov Institute' ,142281 Protvino (Russian Federation); Far Eastern Federal University, School of Biomedicine,690950 Vladivostok (Russian Federation); Goy, V.A. [Far Eastern Federal University, School of Natural Sciences,690950 Vladivostok (Russian Federation); Ilgenfritz, E.M. [Joint Institute for Nuclear Research,BLTP, 141980 Dubna (Russian Federation); Kotov, A.Yu. [Institute of Theoretical and Experimental Physics,117259 Moscow (Russian Federation); Molochkov, A.V. [Far Eastern Federal University, School of Biomedicine,690950 Vladivostok (Russian Federation); Müller-Preussker, M.; Petersson, B. [Humboldt-Universität zu Berlin, Institut für Physik,12489 Berlin (Germany)

    2015-06-16

    The phase diagram of two-color QCD with non-zero chiral chemical potential is studied by means of lattice simulation. We focus on the influence of a chiral chemical potential on the confinement/deconfinement phase transition and the breaking/restoration of chiral symmetry. The simulation is carried out with dynamical staggered fermions without rooting. The dependences of the Polyakov loop, the chiral condensate and the corresponding susceptibilities on the chiral chemical potential and the temperature are presented. The critical temperature is observed to increase with increasing chiral chemical potential.

  20. Flank transparency: transparent filters seen in dynamic two-color displays.

    Science.gov (United States)

    Wollschläger, D; Rodriguez, A M; Hoffman, D D

    2001-01-01

    Flank transparency is the perception of a colored transparent filter evoked by apparent-motion displays containing as few as two colors. Displays of flank transparency contain a random array of line segments placed on a uniform background. Small flanks are added to the line segments if the segments fall in the interior of a moving virtual shape, such as a virtual disk. This leads to the perception of a colored transparent disk with well-defined boundaries moving over the array of lines. Current qualitative and quantitative models of luminance and color conditions for perceptual transparency do not account for flank transparency as they require displays containing at least three different colors.

  1. Spatial properties of a terahertz beam generated from a two-color air plasma

    DEFF Research Database (Denmark)

    Pedersen, Pernille Klarskov; Wang, Tianwu; Buron, Jonas Christian Due

    2013-01-01

    We present a spatial characterization of terahertz (THz) beams generated from a two-color air plasma under different conditions by measuring full 3D beam profiles using a commercial THz camera. We compare two THz beam profiles emitted from plasmas generated by 35 fs and 100 fs laser pulses......, and show that the spatial properties of the two THz beams do not change significantly. For the THz beam profile generated by the 35 fs pulse, the spatial effect of eliminating the lower frequencies is investigated by implementing two crossed polarizers working as a high-pass filter. We show...

  2. Semiconductor cluster beams: One and two color ionization studies of Six and Gex

    OpenAIRE

    Heath, J R; Liu, Yuan; O'Brien, S. C.; Zhang, Qing-ling; Curl, R. F.; Tittel, F.K.; Smalley, R.E.

    1985-01-01

    Supersonic beams of clusters of Si and Ge atoms have been produced by laser vaporization followed by supersonic expansion in a helium carrier. The cluster beams were characterized by F2(7.9 eV) and ArF(6.4 eV) excimer laser ionization accompanied by time-of-flight mass analysis. In addition, the feasibility of a resonant two-photon ionization (R2PI) spectroscopic study was explored by two-color experiments involving initial excitation with the second (2.36 eV) and third (3.54 eV) harmonics of...

  3. Two-color CO2/HeNe laser interferometer for C-2 experiment.

    Science.gov (United States)

    Gornostaeva, O; Deng, B H; Garate, E; Gota, H; Kinley, J; Schroeder, J; Tuszewski, M

    2010-10-01

    A six-channel two-color interferometer has been developed for plasma electron density measurements in the C-2 field reversed configuration experiment. A CO(2) laser is utilized as the main probe beams, while copropagating visible HeNe laser beams are mainly sensitive to vibration. Density measurements in C-2 plasmas have shown that this is a reliable turn-key system. The maximum residual phase noise after vibration compensation is less than ±5°, corresponding to a line integral density of 3×10(18) m(-2). The time resolution for routine operation is 2 μs.

  4. Controlling Nonsequential Double Ionization in Two-Color Circularly Polarized Femtosecond Laser Fields

    Science.gov (United States)

    Mancuso, Christopher A.; Dorney, Kevin M.; Hickstein, Daniel D.; Chaloupka, Jan L.; Ellis, Jennifer L.; Dollar, Franklin J.; Knut, Ronny; Grychtol, Patrik; Zusin, Dmitriy; Gentry, Christian; Gopalakrishnan, Maithreyi; Kapteyn, Henry C.; Murnane, Margaret M.

    2016-09-01

    Atoms undergoing strong-field ionization in two-color circularly polarized femtosecond laser fields exhibit unique two-dimensional photoelectron trajectories and can emit bright circularly polarized extreme ultraviolet and soft-x-ray beams. In this Letter, we present the first experimental observation of nonsequential double ionization in these tailored laser fields. Moreover, we can enhance or suppress nonsequential double ionization by changing the intensity ratio and helicity of the two driving laser fields to maximize or minimize high-energy electron-ion rescattering. Our experimental results are explained through classical simulations, which also provide insight into how to optimize the generation of circularly polarized high harmonic beams.

  5. Stokes image reconstruction for two-color microgrid polarization imaging systems.

    Science.gov (United States)

    Lemaster, Daniel A

    2011-07-18

    The Air Force Research Laboratory has developed a new microgrid polarization imaging system capable of simultaneously reconstructing linear Stokes parameter images in two colors on a single focal plane array. In this paper, an effective method for extracting Stokes images is presented for this type of camera system. It is also shown that correlations between the color bands can be exploited to significantly increase overall spatial resolution. Test data is used to show the advantages of this approach over bilinear interpolation. The bounds (in terms of available reconstruction bandwidth) on image resolution are also provided.

  6. Fluorescence enhancement of single-phase red-blue emit-ting Ba_3MgSi_2O_8:Eu~(2+),Mn~(2+) phosphors via Dy~(3+) addition for plant cultivation

    Institute of Scientific and Technical Information of China (English)

    刘凌云; 王达健; 毛智勇; 刘艳华; 李雪征; 陆启飞

    2009-01-01

    Fluorescence enhancement of red and blue concurrently emitting Ba3MgSi2O8:Eu2+,Mn2+ phosphors for plant cultivation has been investigated by Dy3+ addition.The Ba3MgSi2O8:Eu2+,Mn2+,Dy3+(BMS-EMD) phosphors have two-color emissions at the wavelength peak values of 437 nm and 620 nm at the excitation of 350 nm.The two emission bands are coincident with the absorption spectrum for photosynthesis of plants.An obvious enhancement effect has been observed upon addition of Dy3+ with amount of 0.03 mol%,in which the ...

  7. Coincidence classes in nonorientable manifolds

    Directory of Open Access Journals (Sweden)

    2006-01-01

    Full Text Available We study Nielsen coincidence theory for maps between manifolds of same dimension regardless of orientation. We use the definition of semi-index of a class, review the definition of defective classes, and study the occurrence of defective root classes. We prove a semi-index product formula for lifting maps and give conditions for the defective coincidence classes to be the only essential classes.

  8. Generation of strong terahertz field from two-color laser filamentation and optical rectification

    Science.gov (United States)

    Kuk, Donghoon; Yoo, Yungjun; Oh, Taek Il; You, Yong Sing; Kim, Ki-Yong

    2015-04-01

    We have demonstrated strong-field (>8 MV/cm), high-peak-power (12 MW) THz generation with a bandwidth of >20 THz via two-color laser filamentation. Moderate average power (1.4 mW) is also achieved by using a cryogenically-cooled Ti:sapphire amplifier capable of producing 30 fs, 15 mJ pulses at a 1 kHz repetition rate. For maximal THz generation and transmission, we have used a combination of a thin dichroic waveplate and a large Brewster-angled silicon filter. Here we have used a thin BBO crystal for frequency doubling (800 nm to 400 nm) and observed strong terahertz emission from the crystal itself. We also find that this type of terahertz emission can be optimized to yield more output power compared to two-color photoionization. In both cases, we have used a microbolometer camera for real-time THz beam profiling. This cost-effective THz camera along with our intense THz sources can be a useful tool for nonlinear THz studies including broadband THz spectroscopy and imaging. Work supported by DOE, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering under Award No. 014216-001.

  9. Two-color HgCdTe infrared staring focal plane arrays

    Science.gov (United States)

    Smith, Edward P.; Pham, Le T.; Venzor, Gregory M.; Norton, Elyse; Newton, Michael; Goetz, Paul; Randall, Valerie; Pierce, Gregory; Patten, Elizabeth A.; Coussa, Raymond A.; Kosai, Ken; Radford, William A.; Edwards, John; Johnson, Scott M.; Baur, Stefan T.; Roth, John A.; Nosho, Brett; Jensen, John E.; Longshore, Randolph E.

    2003-12-01

    Raytheon Vision Systems (RVS) in collaboration with HRL Laboratories is contributing to the maturation and manufacturing readiness of third-generation two-color HgCdTe infrared staring focal plane arrays (FPAs). This paper will highlight data from the routine growth and fabrication of 256x256 30μm unit-cell staring FPAs that provide dual-color detection in the mid-wavelength infrared (MWIR) and long-wavelength infrared (LWIR) spectral regions. FPAs configured for MWIR/MWIR, MWIR/LWIR and LWIR/LWIR detection are used for target identification, signature recognition and clutter rejection in a wide variety of space and ground-based applications. Optimized triple-layer-heterojunction (TLHJ) device designs and molecular beam epitaxy (MBE) growth using in-situ controls has contributed to individual bands in all two-color FPA configurations exhibiting high operability (>99%) and both performance and FPA functionality comparable to state-of-the-art single-color technology. The measured spectral cross talk from out-of-band radiation for either band is also typically less than 10%. An FPA architecture based on a single mesa, single indium bump, and sequential mode operation leverages current single-color processes in production while also providing compatibility with existing second-generation technologies.

  10. Direct Characterization of Amyloidogenic Oligomers by Single-Molecule Fluorescence

    National Research Council Canada - National Science Library

    Angel Orte; Neil R. Birkett; Richard W. Clarke; Glyn L. Devlin; Christopher M. Dobson; David Klenerman

    2008-01-01

    .... We describe here the application of a two-color single-molecule fluorescence technique to examine the assembly of oligomeric species formed during the aggregation of the SH3 domain of PI3 kinase...

  11. Use of a Novel Two Color PALM Method to Examine Structural Properties of Drp1 Helical Rings during Mammalian Mitochondrial Fission In Situ

    Science.gov (United States)

    Rosenbloom, Alyssa Blair

    In this thesis, we accomplish two goals: 1) we develop a novel two color photoactivatable light microscopy (PALM) method for imaging in mammalian cells and 2) we explore our original biological question and discern the structural properties of the Drp1 helical ring during fission. We established that mitochondrial membranes can be distinguished with the available photoactivatable fluorescent protein mEos2. However, we were not able to use any of the published photoactivatable and photoswitchable green fluorescent proteins, predominantly because of an inability to identify individual fluorescent events due to rapidity of the photoswitiching. Based on published crystal structures, we created novel Dronpa variants with increasing steric hindrance around the chromophore, likely partially inhibiting the isomerization. We replaced Val157 with isoleucine, leucine, or phenyalanine. DronpaV157F showed no fluorescence and was discarded. DronpaV157I and DronpaV157L showed photoswitchable green fluorescence, with individual fluorescent events that were more easily discerned. DronpaV157L in particular had bright fluorescent events that were well separated when imaged in mammalian cells at 20 Hz. We named this new variant rsKame. Using PALM we successfully imaged rsKame expressed and localized to the mammalian mitochondrial inner membrane. With the novel photoswitchable fluorescent protein, rsKame, available, we returned to the development of a novel two color PALM method. We chose PAmCherry1 as the partner for rsKame since PAmCherry1 has distinct and well separated excitation/emission spectra from rsKame and is not activated by low 405 nm laser power density. We first imaged rsKame with 405 nm activation at (0.61 mW/mm2) and 488 nm activation/excitation (5.87 W/mm 2) to completion. We then imaged PAmCherry1 with increasing 405 nm activation (0.6-6.0 W/mm2) and 561 nm excitation (22 W/mm 2). With the novel PALM imaging method, we labeled the inner and outer mitochondrial

  12. Evolution of the THz Beam Profile from a Two-Color Air Plasma Through a Beam Waist

    DEFF Research Database (Denmark)

    Strikwerda, Andrew; Pedersen, Pernille Klarskov; Jepsen, Peter Uhd

    2013-01-01

    We experimentally measure the profile of a THz beam generated by a two-color air plasma as it passes through a beam waist, and show that it can be approximated as a Bessel-Gauss beam.......We experimentally measure the profile of a THz beam generated by a two-color air plasma as it passes through a beam waist, and show that it can be approximated as a Bessel-Gauss beam....

  13. Multiscale Monte Carlo equilibration: Two-color QCD with two fermion flavors

    CERN Document Server

    Detmold, William

    2016-01-01

    We demonstrate the applicability of a recently proposed multi-scale thermalization algorithm to two-color quantum chromodynamics (QCD) with two mass-degenerate fermion flavors. The algorithm involves refining an ensemble of gauge configurations that had been generated using a renormalization group (RG) matched coarse action, thereby producing a fine ensemble that is close to the thermalized distribution of a target fine action; the refined ensemble is subsequently rethermalized using conventional algorithms. Although the generalization of this algorithm from pure Yang-Mills theory to QCD with dynamical fermions is straight-forward, we find that in the latter case, the method is susceptible to numerical instabilities during the initial stages of rethermalization when using the hybrid Monte Carlo algorithm. We find that these instabilities arise from large fermion forces in the evolution, which are attributed to an accumulation of spurious near-zero modes of the Dirac operator. We propose a simple strategy for ...

  14. Two-color Photodetectors%双波段光电探测器

    Institute of Scientific and Technical Information of China (English)

    刘铁权; 但伟

    2000-01-01

    Photodetectors are the critical parts for implementation of optoelectoronic detection and various optoelectronic technology. The paper introduces two-color photodetectors made of silicon integrated with InGaAs. These photodetectors can detect and respond incident light with the range of 400~1 100 nm and 1 100~1 650 nm simultaneously.%光电探测器是实现光电检测及各种光电技术的核心部件。文章介绍采用Si和In-GaAs两种材料集成制作的双波段光电探测器,它能同时探测并区分400~1100nm和1100~1 650 nm波段的入射光。

  15. Remote creation of strong and coherent emissions in air with two-color ultrafast laser pulses

    CERN Document Server

    Yao, Jinping; Jing, Chenrui; Zeng, Bin; Chu, Wei; Ni, Jielei; Zhang, Haisu; Xie, Hongqiang; Zhang, Chaojin; Li, Helong; Xu, Huailiang; Chin, See Leang; Cheng, Ya; Xu, Zhizhan

    2012-01-01

    We experimentally demonstrate generation of strong narrow-bandwidth emissions with excellent coherent properties at ~391 nm and ~428 nm from molecular ions of nitrogen inside a femtosecond filament in air by an orthogonally polarized two-color driver field (i. e., 800 nm laser pulse and its second harmonic). The durations of the coherent emissions at 391 nm and 428 nm are measured to be ~2.4 ps and ~7.8 ps respectively, both of which are much longer than the duration of the pump and its second harmonic pulses. Furthermore, the measured temporal decay characteristics of the excited molecular systems suggest an "instantaneous" population inversion mechanism that may be achieved in molecular nitrogen ions at an ultrafast time scale comparable to the 800 nm pump pulse.

  16. Statistical analysis of efficient unbalanced factorial designs for two-color microarray experiments.

    Science.gov (United States)

    Tempelman, Robert J

    2008-01-01

    Experimental designs that efficiently embed a fixed effects treatment structure within a random effects design structure typically require a mixed-model approach to data analyses. Although mixed model software tailored for the analysis of two-color microarray data is increasingly available, much of this software is generally not capable of correctly analyzing the elaborate incomplete block designs that are being increasingly proposed and used for factorial treatment structures. That is, optimized designs are generally unbalanced as it pertains to various treatment comparisons, with different specifications of experimental variability often required for different treatment factors. This paper uses a publicly available microarray dataset, as based upon an efficient experimental design, to demonstrate a proper mixed model analysis of a typical unbalanced factorial design characterized by incomplete blocks and hierarchical levels of variability.

  17. Magnetic catalysis (and inverse catalysis) at finite temperature in two-color lattice QCD

    CERN Document Server

    Ilgenfritz, E -M; Petersson, B; Schreiber, A

    2013-01-01

    Two-color lattice QCD with N_f=4 staggered fermion degrees of freedom (no rooting trick is applied) with equal electric charge q is studied in a homogeneous magnetic background field B and at non-zero temperature T. In order to circumvent renormalization as a function of the bare coupling we apply a fixed-scale approach. We study the influence of the magnetic field on the critical temperature. At rather small pseudo-scalar meson mass (m_pi \\approx 175 MeV \\approx T_c(B=0)) we confirm magnetic catalysis for sufficiently strong magnetic field strength, while at T=195 MeV and weak magnetic field (qB {\\lesssim} 0.8 GeV^2) we find a rise of the Polyakov loop with qB and thus, indications for an inverse magnetic catalysis.

  18. Calibration of a two-color soft x-ray diagnostic for electron temperature measurement

    Energy Technology Data Exchange (ETDEWEB)

    Reusch, L. M., E-mail: lmmcguire@wisc.edu; Den Hartog, D. J.; Goetz, J.; McGarry, M. B. [University of Wisconsin - Madison, Madison, Wisconsin 53703 (United States); Franz, P. [Consorzio RFX, Padova (Italy); Stephens, H. D. [University of Wisconsin - Madison, Madison, Wisconsin 53703 (United States); Pierce College Fort Steilacoom, Lakewood, Washington 98498 (United States)

    2016-11-15

    The two-color soft x-ray (SXR) tomography diagnostic on the Madison Symmetric Torus is capable of making electron temperature measurements via the double-filter technique; however, there has been a 15% systematic discrepancy between the SXR double-filter (SXR{sub DF}) temperature and Thomson scattering (TS) temperature. Here we discuss calibration of the Be filters used in the SXR{sub DF} measurement using empirical measurements of the transmission function versus energy at the BESSY II electron storage ring, electron microprobe analysis of filter contaminants, and measurement of the effective density. The calibration does not account for the TS and SXR{sub DF} discrepancy, and evidence from experiments indicates that this discrepancy is due to physics missing from the SXR{sub DF} analysis rather than instrumentation effects.

  19. Synthesis of Two-Color Laser Pulses for the Harmonic Cutoff Extension

    Science.gov (United States)

    Wang, Guo-Li; Zhou, Li-Hua; Zhao, Song-Feng; Zhou, Xiao-Xin

    2016-05-01

    Increasing simultaneously both the cutoff energy and efficiency is a big challenge to all applications of high-order harmonic generation (HHG). For this purpose, the shaping of the waveform of driving pulse is an alternative approach. Here, we show that the harmonic cutoff can be extended by about two times without reducing harmonic yield after considering macroscopic propagation effects, by adopting a practical way to synthesize two-color fields with fixed energy. Our results, combined with the experimental techniques, show the great potential of HHG as a tabletop light source. Supported by the National Natural Science Foundation of China under Grant Nos. 11264036, 11164025, 11364038, the Specialized Research Fund for the Doctoral Program of Higher Education of China under Grant No. 20116203120001, and the Basic Scientific Research Foundation for Institution of Higher Learning of Gansu Province

  20. Biosynthetic labeling and two-color imaging of phospholipids in cells.

    Science.gov (United States)

    Jao, Cindy Y; Roth, Mary; Welti, Ruth; Salic, Adrian

    2015-02-09

    Phospholipids with a choline head group are abundant components of all biological membranes, performing critical functions in cellular structure, metabolism, and signaling. In spite of their importance, our ability to visualize choline phospholipids in vivo remains very limited. We present a simple and robust chemical strategy to image choline phospholipids, based on the metabolic incorporation of azidocholine analogues, that accurately reflects the normal biosynthetic incorporation of choline into cellular phospholipids. Azidocholine-labeled phospholipids can be imaged in cells with high sensitivity and resolution, following derivatization with fluorophores, by bio-orthogonal chemical reactions compatible with live-cell imaging. We used this method to visualize the subcellular localization of choline phospholipids. We also demonstrate that double metabolic labeling with azidocholine and propargylcholine allows sensitive two-color imaging of choline phospholipids. Our method represents a powerful approach to directly image phospholipids, and to study their dynamics in cells and tissues.

  1. Enhanced hole boring with two-color relativistic laser pulses in the fast ignition scheme

    Science.gov (United States)

    Yu, Changhai; Deng, Aihua; Tian, Ye; Li, Wentao; Wang, Wentao; Zhang, Zhijun; Qi, Rong; Wang, Cheng; Liu, Jiansheng

    2016-08-01

    A scheme of using two-color laser pulses for hole boring into overdense plasma as well as energy transfer into electron and ion beams has been studied using particle-in-cell simulations. Following an ultra-short ultra-intense hole-boring laser pulse with a short central wavelength in extreme ultra-violet range, the main infrared driving laser pulse can be guided in the hollow channel preformed by the former laser and propagate much deeper into an overdense plasma, as compared to the case using the infrared laser only. In addition to efficiently transferring the main driving laser energy into energetic electrons and ions generation deep inside the overdense plasma, the ion beam divergence can be greatly reduced. The results might be beneficial for the fast ignition concept of inertial confinement fusion.

  2. Mechanisms of two-color laser-induced field-free molecular orientation.

    Science.gov (United States)

    Spanner, Michael; Patchkovskii, Serguei; Frumker, Eugene; Corkum, Paul

    2012-09-14

    Two mechanisms of two-color (ω+2ω) laser-induced field-free molecular orientation, based on the hyperpolarizability and ionization depletion, are explored and compared. The CO molecule is used as a computational example. While the hyperpolarizability mechanism generates small amounts of orientation at intensities below the ionization threshold, ionization depletion quickly becomes the dominant mechanism as soon as ionizing intensities are reached. Only the ionization mechanism leads to substantial orientation (e.g., on the order of ≳0.1). For intensities typical of laser-induced molecular alignment and orientation experiments, the two mechanisms lead to robust, characteristic timings of the field-free orientation wave-packet revivals relative to the alignment revivals and the revival time. The revival timings can be used to detect the active orientation mechanism experimentally.

  3. THz wave emission from argon in two-color laser field

    Institute of Scientific and Technical Information of China (English)

    杜玲玲; 赵松峰; 周效信; 赵增秀

    2015-01-01

    Terahertz (THz) wave emission from argon atom in a two-color laser pulses is studied numerically by solving the one-dimensional (1D) time-dependent Schr ¨odinger equation. The THz spectra we obtained include both discontinuous and continuum ones. By using the special basis functions that we previously proposed, our analysis points out that the discontinuous and continuum parts are contributed by bound–bound and continuum–continuum transition of atomic energy levels. Although the atomic wave function is strongly dressed during the interaction with laser fields, our identification for the discontinuous part of the THz wave shows that the transition between highly excited bound states can still be well described by the field-free basis function in the tunneling ionization regime.

  4. Two-color resonance photoionization spectrum of nickelocene in a supersonic jet

    Science.gov (United States)

    Ketkov, S. Yu.; Selzle, H. L.; Schlag, E. W.; Titova, S. N.; Kalakutskaya, L. V.

    2004-10-01

    Two-color photoionization of nickelocene molecules cooled in a supersonic jet is performed using a tunable nanosecond pulsed laser. The first stage of the multiphoton excitation is the transition from the highest occupied molecular orbital of nickelocene to the lowest Rydberg level. Conditions are found under which molecular ions (η 5-C5H5)2Ni+ are the only product of the multiphoton ionization in the one-color experiment. Irradiation of an excited molecule by an intense pulse of another laser increases significantly the yield of molecular ions. The dependence of the yield of (η5-C5H5)2Ni+ ions on the frequency of the second laser makes it possible to determine the adiabatic ionization potential of nickelocene as 6.138±0.012eV.

  5. Calibration of a two-color soft x-ray diagnostic for electron temperature measurement

    Science.gov (United States)

    Reusch, L. M.; Den Hartog, D. J.; Franz, P.; Goetz, J.; McGarry, M. B.; Stephens, H. D.

    2016-11-01

    The two-color soft x-ray (SXR) tomography diagnostic on the Madison Symmetric Torus is capable of making electron temperature measurements via the double-filter technique; however, there has been a 15% systematic discrepancy between the SXR double-filter (SXRDF) temperature and Thomson scattering (TS) temperature. Here we discuss calibration of the Be filters used in the SXRDF measurement using empirical measurements of the transmission function versus energy at the BESSY II electron storage ring, electron microprobe analysis of filter contaminants, and measurement of the effective density. The calibration does not account for the TS and SXRDF discrepancy, and evidence from experiments indicates that this discrepancy is due to physics missing from the SXRDF analysis rather than instrumentation effects.

  6. BEC-BCS crossover in a cold and magnetized two color NJL model

    CERN Document Server

    Duarte, Dyana C; Farias, R L S; Manso, Pedro H A; Ramos, Rudnei O; Scoccola, N N

    2016-01-01

    The BEC-BCS crossover for a NJL model with diquark interactions is studied in the presence of an external magnetic field. Particular attention is paid to different regularization schemes used in the literature. A thorough comparison of results is performed for the case of a cold and magnetized two-color NJL model. According to our results, the critical chemical potential for the BEC transition exhibits a clear inverse magnetic catalysis effect for magnetic fields in the range $ 1 \\lesssim eB/m_\\pi^2 \\lesssim 20 $. As for the BEC-BCS crossover, the corresponding critical chemical potential is very weakly sensitive to magnetic fields up to $eB \\sim 9\\ m_\\pi^2$, showing a much smaller inverse magnetic catalysis as compared to the BEC transition, and displays a strong magnetic catalysis from this point on.

  7. Frequency doubler and two-color mode of operation at free electron laser FLASH2

    Science.gov (United States)

    Kuhlmann, M.; Schneidmiller, E. A.; Yurkov, M. V.

    2017-06-01

    We report on the results of the first operation of a frequency doubler at FLASH2. The scheme uses the feature of the variable gap of the undulator. Undulator is divided in two parts. The second part of the undulator is tuned to the double frequency of the first part. Modulated electron beam enters the second part of the undulator and generates radiation at the 2nd harmonic. Depending on a balance between the gain of undulator sections, frequency doubler allows operation in a two-color mode and operation at shorter wavelengths with respect to standard SASE scheme. The shortest wavelength of 3.1 nm (photon energy 400 eV) has been achieved at FLASH2 with frequency doubler scheme, which is significantly below the design value for the standard SASE option.

  8. Video Histories, Memories, and Coincidences

    DEFF Research Database (Denmark)

    Kacunko, Slavko

    2012-01-01

    Looping images allows us to notice things that we have never noticed before. Looping a small but exquisite selection of the video tapes of Marcel Odenbach, Dieter Kiessling and Matthias Neuenhofer may allow the discovering of Histories, Coincidences, and Infinitesimal Aesthetics inscribed...... into the Video medium as its unsurpassed topicality....

  9. Frequency modulation of high-order harmonic generation in an orthogonally polarized two-color laser field.

    Science.gov (United States)

    Li, Guicun; Zheng, Yinghui; Ge, Xiaochun; Zeng, Zhinan; Li, Ruxin

    2016-08-08

    We have experimentally investigated the frequency modulation of high-order harmonics in an orthogonally polarized two-color laser field consisting of a mid-infrared 1800nm fundamental pulse and its second harmonic pulse. It is demonstrated that the high harmonic spectra can be fine-tuned as we slightly change the relative delay of the two-color laser pulses. By analyzing the relative frequency shift of each harmonic at different two-color delays, the nonadiabatic spectral shift induced by the rapid variation of the intensity-dependent intrinsic dipole phase can be distinguished from the blueshift induced by the change of the refractive index during self-phase modulation (SPM). Our comprehensive analysis shows that the frequency modulation pattern is a reflection of the average emission time of high-order harmonic generation (HHG), thus offering a simple method to fine-tune the spectra of the harmonics on a sub-cycle time scale.

  10. Two-color infrared FEL facility employing a 250-MeV linac injector of Saga synchrotron light source

    CERN Document Server

    Tomimasu, T; Koga, N; Hashiguchi, Y; Ochiai, Y; Ishibashi, M

    2001-01-01

    A two-color infrared free electron laser (FEL) facility is proposed. This FEL facility will employ a new 250-MeV linac injector of the Saga synchrotron light source (SLS). The linac has two operation modes: short macropulse mode of 1 mu s at 250 MeV is for injection to a 1.4-GeV storage ring and long macropulse mode of 13 mu s at 40 MeV is for the two-color FEL facility. The two-color FEL uses a single electron beam and simultaneously provides both infrared (IR) and far-IR laser pulses for pump-probe studies of quantum-well structures and studying vibrational relaxation of molecules. The Saga SLS will be operated in 2004 to promote material science, bio-medical and industrial applications in Kyushu.

  11. Femtosecond laser-induced periodic surface structures on silicon upon polarization controlled two-color double-pulse irradiation.

    Science.gov (United States)

    Höhm, Sandra; Herzlieb, Marcel; Rosenfeld, Arkadi; Krüger, Jörg; Bonse, Jörn

    2015-01-12

    Two-color double-fs-pulse experiments were performed on silicon wafers to study the temporally distributed energy deposition in the formation of laser-induced periodic surface structures (LIPSS). A Mach-Zehnder interferometer generated parallel or cross-polarized double-pulse sequences at 400 and 800 nm wavelength, with inter-pulse delays up to a few picoseconds between the sub-ablation 50-fs-pulses. Multiple two-color double-pulse sequences were collinearly focused by a spherical mirror to the sample. The resulting LIPSS characteristics (periods, areas) were analyzed by scanning electron microscopy. A wavelength-dependent plasmonic mechanism is proposed to explain the delay-dependence of the LIPSS. These two-color experiments extend previous single-color studies and prove the importance of the ultrafast energy deposition for LIPSS formation.

  12. Spatially resolved two-color diffusion measurements in human skin applied to transdermal liposome penetration.

    Science.gov (United States)

    Brewer, Jonathan; Bloksgaard, Maria; Kubiak, Jakub; Sørensen, Jens Ahm; Bagatolli, Luis A

    2013-05-01

    A multiphoton excitation-based fluorescence fluctuation spectroscopy method, Raster image correlation spectroscopy (RICS), was used to measure the local diffusion coefficients of distinct model fluorescent substances in excised human skin. In combination with structural information obtained by multiphoton excitation fluorescence microscopy imaging, the acquired diffusion information was processed to construct spatially resolved diffusion maps at different depths of the stratum corneum (SC). Experiments using amphiphilic and hydrophilic fluorescently labeled molecules show that their diffusion in SC is very heterogeneous on a microscopic scale. This diffusion-based strategy was further exploited to investigate the integrity of liposomes during transdermal penetration. Specifically, the diffusion of dual-color fluorescently labeled liposomes--containing an amphiphilic fluorophore in the lipid bilayer and a hydrophilic fluorophore encapsulated in the liposome lumen--was measured using cross-correlation RICS. This type of experiment allows discrimination between separate (uncorrelated) and joint (correlated) diffusion of the two different fluorescent probes, giving information about liposome integrity. Independent of the liposome composition (phospholipids or transfersomes), our results show a clear lack of cross-correlation below the skin surface, indicating that the penetration of intact liposomes is highly compromised by the skin barrier.

  13. Opportunities for two-color experiments at the SASE3 undulator line of the European XFEL

    Energy Technology Data Exchange (ETDEWEB)

    Geloni, Gianluca; Mazza, Tommaso; Meyer, Michael; Serkez, Svitozar [European XFEL GmbH, Hamburg (Germany); Kocharyan, Vitali; Saldin, Evgeni [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2017-06-15

    X-ray Free Electron Lasers (XFELs) have been proven to generate short and powerful radiation pulses allowing for a wide class of novel experiments. If an XFEL facility supports the generation of two X-ray pulses with different wavelengths and controllable delay, the range of possible experiments is broadened even further to include X-ray-pump/X-ray-probe applications. In this work we discuss the possibility of applying a simple and cost-effective method for producing two-color pulses at the SASE3 soft X-ray beamline of the European XFEL. The technique is based on the installation of a magnetic chicane in the baseline undulator and can be accomplished in several steps. We discuss the scientific interest of this upgrade for the Small Quantum Systems (SQS) instrument, in connection with the high-repetition rate of the European XFEL, and we provide start-to-end simulations up to the radiation focus on the sample, proving the feasibility of our concept.

  14. Enhanced sensitivity in H photofragment detection by two-color reduced-Doppler ion imaging

    Energy Technology Data Exchange (ETDEWEB)

    Epshtein, Michael; Portnov, Alexander; Kupfer, Rotem; Rosenwaks, Salman; Bar, Ilana, E-mail: ibar@bgu.ac.il [Department of Physics, Ben-Gurion University of the Negev, Beer-Sheva 84105 (Israel)

    2013-11-14

    Two-color reduced-Doppler (TCRD) and one-color velocity map imaging (VMI) were used for probing H atom photofragments resulting from the ∼243.1 nm photodissociation of pyrrole. The velocity components of the H photofragments were probed by employing two counterpropagating beams at close and fixed wavelengths of 243.15 and 243.12 nm in TCRD and a single beam at ∼243.1 nm, scanned across the Doppler profile in VMI. The TCRD imaging enabled probing of the entire velocity distribution in a single pulse, resulting in enhanced ionization efficiency, as well as improved sensitivity and signal-to-noise ratio. These advantages were utilized for studying the pyrrole photodissociation at ∼243.1 and 225 nm, where the latter wavelength provided only a slight increase in the H yield over the self-signal from the probe beams. The TCRD imaging enabled obtaining high quality H{sup +} images, even for the low H photofragment yields formed in the 225 nm photolysis process, and allowed determining the velocity distributions and anisotropy parameters and getting insight into pyrrole photodissociation.

  15. Goulphar: rapid access and expertise for standard two-color microarray normalization methods

    Directory of Open Access Journals (Sweden)

    Servant Nicolas

    2006-10-01

    Full Text Available Abstract Background Raw data normalization is a critical step in microarray data analysis because it directly affects data interpretation. Most of the normalization methods currently used are included in the R/BioConductor packages but it is often difficult to identify the most appropriate method. Furthermore, the use of R commands for functions and graphics can introduce mistakes that are difficult to trace. We present here a script written in R that provides a flexible means of access to and monitoring of data normalization for two-color microarrays. This script combines the power of BioConductor and R analysis functions and reduces the amount of R programming required. Results Goulphar was developed in and runs using the R language and environment. It combines and extends functions found in BioConductor packages (limma and marray to correct for dye biases and spatial artifacts. Goulphar provides a wide range of optional and customizable filters for excluding incorrect signals during the pre-processing step. It displays informative output plots, enabling the user to monitor the normalization process, and helps adapt the normalization method appropriately to the data. All these analyses and graphical outputs are presented in a single PDF report. Conclusion Goulphar provides simple, rapid access to the power of the R/BioConductor statistical analysis packages, with precise control and visualization of the results obtained. Complete documentation, examples and online forms for setting script parameters are available from http://transcriptome.ens.fr/goulphar/.

  16. Phase diagram of dense two-color QCD within lattice simulations

    Science.gov (United States)

    Braguta, V. V.; Ilgenfritz, E.-M.; Kotov, A. Yu.; Molochkov, A. V.; Nikolaev, A. A.

    2017-03-01

    We present the results of a low-temperature scan of the phase diagram of dense two-color QCD with Nf = 2 quarks. The study is conducted using lattice simulation with rooted staggered quarks. At small chemical potential we observe the hadronic phase, where the theory is in a confining state, chiral symmetry is broken, the baryon density is zero and there is no diquark condensate. At the critical point μ = mπ/2 we observe the expected second order transition to Bose-Einstein condensation of scalar diquarks. In this phase the system is still in confinement in conjunction with nonzero baryon density, but the chiral symmetry is restored in the chiral limit. We have also found that in the first two phases the system is well described by chiral perturbation theory. For larger values of the chemical potential the system turns into another phase, where the relevant degrees of freedom are fermions residing inside the Fermi sphere, and the diquark condensation takes place on the Fermi surface. In this phase the system is still in confinement, chiral symmetry is restored and the system is very similar to the quarkyonic state predicted by SU(Nc) theory at large Nc.

  17. Two-color detector: Mercury-cadmium-telluride as a terahertz and infrared detector

    Energy Technology Data Exchange (ETDEWEB)

    Sizov, F.; Zabudsky, V.; Petryakov, V.; Golenkov, A.; Andreyeva, K.; Tsybrii, Z. [Institute of Semiconductor Physics, 03028 Kiev (Ukraine); Dvoretskii, S. [Institute of Semiconductor Physics of SB RAS, 630090 Novosibirsk (Russian Federation)

    2015-02-23

    In this paper, issues associated with the development of infrared (IR) and terahertz (THz) radiation detectors based on HgCdTe are discussed. Two-color un-cooled and cooled to 78 K narrow-gap mercury-cadmium-telluride semiconductor thin layers with antennas were considered both as sub-THz (sub-THz) direct detection bolometers and 3–10 μm IR photoconductors. The noise equivalent power (NEP) for one of the detectors studied at ν ≈ 140 GHz reaches NEP{sub 300 K} ≈ 4.5 × 10{sup −10} W/Hz{sup 1/2} and NEP{sub 78 K} ≈ 5 × 10{sup −9} W/Hz{sup 1/2}. The same detector used as an IR photoconductor showed the responsivity at temperatures T = 78 K and 300 K with signal-to-noise ratio S/N ≈ 750 and 50, respectively, under illumination by using IR monochromator and globar as a thermal source.

  18. Trajectory selection in high harmonic generation by controlling the phase between orthogonal two-color fields.

    Science.gov (United States)

    Brugnera, Leonardo; Hoffmann, David J; Siegel, Thomas; Frank, Felix; Zaïr, Amelle; Tisch, John W G; Marangos, Jonathan P

    2011-10-07

    We demonstrate control of short and long quantum trajectories in high harmonic emission through the use of an orthogonally polarized two-color field. By controlling the relative phase ϕ between the two fields we show via classical and quantum calculations that we can steer the two-dimensional trajectories to return, or not, to the core and so control the relative strength of the short or long quantum trajectory contribution. In experiments, we demonstrate that this leads to robust control over the trajectory contributions using a drive field from a femtosecond laser composed of the fundamental ω at 800 nm (intensity ∼1.2×10(14)  W cm(-2)) and its weaker orthogonally polarized second harmonic 2ω (intensity ∼0.3×10(14)  W cm(-2)) with the relative phase between the ω and 2ω fields varied simply by tilting a fused silica plate. This is the first demonstration of short and long quantum trajectory control at the single-atom level.

  19. Study of the phase diagram of dense two-color QCD within lattice simulation

    CERN Document Server

    Braguta, V V; Kotov, A Yu; Molochkov, A V; Nikolaev, A A

    2016-01-01

    In this paper we carry out a low-temperature scan of the phase diagram of dense two-color QCD with $N_f=2$ quarks. The study is conducted using lattice simulation with rooted staggered quarks. At small chemical potential we observe the hadronic phase, where the theory is in a confining state, chiral symmetry is broken, the baryon density is zero and there is no diquark condensate. At the critical point $\\mu = m_{\\pi}/2$ we observe the expected second order transition to Bose-Einstein condensation of scalar diquarks. In this phase the system is still in confinement in conjunction with nonzero baryon density, but the chiral symmetry is restored in the chiral limit. We have also found that in the first two phases the system is well described by chiral perturbation theory. For larger values of the chemical potential the system turns into another phase, where the relevant degrees of freedom are fermions residing inside the Fermi sphere, and the diquark condensation takes place on the Fermi surface. In this phase t...

  20. Radiation damage free two-color X-ray ghost diffraction with atomic resolution

    CERN Document Server

    Li, Zheng; Chapman, Henry; Shih, Yanhua

    2015-01-01

    The X-ray free electron lasers (XFEL) can enable diffractive structural determination of protein crystals or single molecules that are too small and radiation-sensitive for conventional X-ray analysis. However the electronic form factor could have been modified during the ultrashort X-ray pulse due to photoionization and electron cascade caused by the intense X-ray pulse. For general X-ray imaging techniques, to minimize radiation damage effect is of major concern to ensure faithful reconstruction of the structure. Here we show that a radiation damage free diffraction can be achieved with an atomic spatial resolution, by using X-ray parametric down-conversion (PDC), and two-color biphoton ghost imaging. We illustrate that formation of the diffractive patterns satisfies a condition analogous to the Bragg equation, with a resolution that could be as fine as the lattice length scale of several Angstrom. Because the samples are illuminated by the optical photons of low energy, they can be free of radiation damage...

  1. Spatially Resolved Two-Color Diffusion Measurements in Human Skin Applied to Transdermal Liposome Penetration

    DEFF Research Database (Denmark)

    Brewer, Jonathan; Bloksgaard, Maria; Kubiak, Jakub

    2013-01-01

    A multiphoton excitation-based fluorescence fluctuation spectroscopy method, Raster image correlation spectroscopy (RICS), was used to measure the local diffusion coefficients of distinct model fluorescent substances in excised human skin. In combination with structural information obtained...... of the liposome composition (phospholipids or transfersomes), our results show a clear lack of cross-correlation below the skin surface, indicating that the penetration of intact liposomes is highly compromised by the skin barrier.Journal of Investigative Dermatology advance online publication, 6 December 2012...... is very heterogeneous on a microscopic scale. This diffusion-based strategy was further exploited to investigate the integrity of liposomes during transdermal penetration. Specifically, the diffusion of dual-color fluorescently labeled liposomes-containing an amphiphilic fluorophore in the lipid bilayer...

  2. Digital coincidence counting - initial results

    Science.gov (United States)

    Butcher, K. S. A.; Watt, G. C.; Alexiev, D.; van der Gaast, H.; Davies, J.; Mo, Li; Wyllie, H. A.; Keightley, J. D.; Smith, D.; Woods, M. J.

    2000-08-01

    Digital Coincidence Counting (DCC) is a new technique in radiation metrology, based on the older method of analogue coincidence counting. It has been developed by the Australian Nuclear Science and Technology Organisation (ANSTO), in collaboration with the National Physical Laboratory (NPL) of the United Kingdom, as a faster more reliable means of determining the activity of ionising radiation samples. The technique employs a dual channel analogue-to-digital converter acquisition system for collecting pulse information from a 4π beta detector and an NaI(Tl) gamma detector. The digitised pulse information is stored on a high-speed hard disk and timing information for both channels is also stored. The data may subsequently be recalled and analysed using software-based algorithms. In this letter we describe some recent results obtained with the new acquistion hardware being tested at ANSTO. The system is fully operational and is now in routine use. Results for 60Co and 22Na radiation activity calibrations are presented, initial results with 153Sm are also briefly mentioned.

  3. Phase diagram of two-color QCD in a Dyson-Schwinger approach

    Energy Technology Data Exchange (ETDEWEB)

    Buescher, Pascal Joachim

    2014-04-28

    We investigate two-color QCD with N{sub f}=2 at finite temperatures and chemical potentials using a Dyson-Schwinger approach. We employ two different truncations for the quark loop in the gluon DSE: one based on the Hard-Dense/Hard-Thermal Loop (HDTL) approximation of the quark loop and one based on the back-coupling of the full, self-consistent quark propagator (SCQL). We compare results for the different truncations with each other as well as with other approaches. As expected, we find a phase dominated by the condensation of quark-quark pairs. This diquark condensation phase overshadows the critical end point and first-order phase transition which one finds if diquark condensation is neglected. The phase transition from the phase without diquark condensation to the diquark-condensation phase is of second order. We observe that the dressing with massless quarks in the HDTL approximation leads to a significant violation of the Silver Blaze property and to a too small diquark condensate. The SCQL truncation, on the other hand, is found to reproduce all expected features of the μ-dependent quark condensates. Moreover, with parameters adapted to the situation in other approaches, we also find good to very good agreement with model and lattice calculations in all quark quantities. We find indictions that the physics in recent lattice calculations is likely to be driven solely by the explicit chiral symmetry breaking. Discrepancies w.r.t. the lattice are, however, observed in two quantities that are very sensitive to the screening of the gluon propagator, the dressed gluon propagator itself and the phase-transition line at high temperatures.

  4. Three-Dimensional Control of DNA Hybridization by Orthogonal Two-Color Two-Photon Uncaging.

    Science.gov (United States)

    Fichte, Manuela A H; Weyel, Xenia M M; Junek, Stephan; Schäfer, Florian; Herbivo, Cyril; Goeldner, Maurice; Specht, Alexandre; Wachtveitl, Josef; Heckel, Alexander

    2016-07-25

    We successfully introduced two-photon-sensitive photolabile groups ([7-(diethylamino)coumarin-4-yl]methyl and p-dialkylaminonitrobiphenyl) into DNA strands and demonstrated their suitability for three-dimensional photorelease. To visualize the uncaging, we used a fluorescence readout based on double-strand displacement in a hydrogel and in neurons. Orthogonal two-photon uncaging of the two cages is possible, thus enabling complex scenarios of three-dimensional control of hybridization with light.

  5. Ionization in Orthogonal Two-Color Laser Fields - Origin and Phase Dependence of Trajectory-Resolved Coulomb Effects

    CERN Document Server

    Richter, Martin; Schöffler, Markus; Jahnke, Till; Schmidt, Lothar Ph H; Dörner, Reinhard

    2016-01-01

    We report on electron momentum distributions from single ionization of Ar in strong orthogonally polarized two-color (OTC) laser fields measured with the COLTRIMS technique. We study the effect of Coulomb focusing whose signature is a cusp like feature in the center of the electron momentum spectrum. While the direct electrons show the expected strong dependence on the phase between the two colors, surprisingly the Coulomb focused structure is almost not influenced by the weak second harmonic streaking field. This effect is explained by the use of a CTMC simulation which describes the tunneled electron wave packet in terms of classical trajectories under the influence of the combined Coulomb- and OTC laser field. We find a subtle interplay between the initial momentum of the electron upon tunneling, the ionization phase and the action of the Coulomb field that makes the Coulomb focused part of the momentum spectrum apparently insensitive to the weaker streaking field.

  6. Matching-based fresh-slice method for generating two-color x-ray free-electron lasers

    Directory of Open Access Journals (Sweden)

    Weilun Qin

    2017-09-01

    Full Text Available Two-color high intensity x-ray free-electron lasers (FELs provide powerful tools for probing ultrafast dynamic systems. A novel concept of realizing fresh-slice two-color lasing through slice-dependent transverse mismatch has been proposed by one of the authors [Y. Chao, SLAC Report No. SLAC-PUB-16935, 2016]. In this paper we present a feasible example following this concept based on the Linac Coherent Light Source parameters. Time-dependent mismatch along the bunch is generated by a passive dechirper module and controlled by downstream matching sections, enabling FEL lasing at different wavelength with a split undulator configuration. Simulations for soft x-ray FELs show that tens of gigawatts pulses with femtosecond duration can be generated.

  7. Channel-resolved subcycle interferences of electron wave packets emitted from H$_2$ in two-color laser fields

    CERN Document Server

    Xie, Xinhua; Kartashov, Daniil; Zhang, Li; Baltuška, Andrius; Kitzler, Markus

    2016-01-01

    We report on the observation of subcycle interferences of electron wave packets released during the strong field ionization of H$_2$ with cycle-shaped two-color laser fields. With a reaction microscope, channel-resolved photoelectron momentum distribution are obtained for different final products originating from single ionization of H$_2$. Our results show that the subcycle interference structures of electron wave packet are very sensitive to the cycle-shape of the two-color laser field. The reason is that the ionization time within an optical cycle is determined by the cycle-shape of the laser field. The subcycle interference structures can be further used to get the subcycle dynamics of molecules during strong field interaction.

  8. Density profiles of small Dirac operator eigenvalues for two color QCD at nonzero chemical potential compared to matrix models

    Energy Technology Data Exchange (ETDEWEB)

    Akemann, Gernot [Service de Physique Theorique, CEA/DSM/SPhT Saclay, Unite associee CNRS/SPM/URA 2306, F-91191 Gif-sur-Yvette Cedex (France); Department of Mathematical Sciences, Brunel University West London, Uxbridge, UB8 3PH (United Kingdom); Bittner, Elmar [Institut fuer Theoretische Physik, Universitaet Leipzig, Augustplatz 10/11, D-04109 Leipzig (Germany); Lombardo, Maria-Paola [INFN-Laboratori Nazionali di Frascati, I-00044 Frascati (Italy); Markum, Harald [Atominstitut, Technische Universitaet Wien, A-1040 Vienna (Austria); Pullirsch, Rainer [Atominstitut, Technische Universitaet Wien, A-1040 Vienna (Austria)

    2005-03-15

    We investigate the eigenvalue spectrum of the staggered Dirac matrix in two color QCD at finite chemical potential. The profiles of complex eigenvalues close to the origin are compared to a complex generalization of the chiral Gaussian Symplectic Ensemble, confirming its predictions for weak and strong non-Hermiticity. They differ from the QCD symmetry class with three colors by a level repulsion from both the real and imaginary axis.

  9. Improved treatment of the turning point in tunnel ionization of atoms in a low-frequency two color laser field

    Science.gov (United States)

    Petrović, V. M.; Miladinović, T. B.

    2016-12-01

    The tunneling photoionization rate for a two color (bichromatic) field consisting of coherent superposition of the fundamental laser field frequency ω and its second harmonic with frequency 2ω , was studied theoretically within the framework of the adiabatic Landau-Dykhne approach. Analytical expressions were derived for the case of fixed specified values of relative phase shift, \\varphi =0 between the harmonics of the incident bichromatic field.

  10. Generation of an isolated sub-30 attosecond pulse in a two-color laser field and a static electric field

    Institute of Scientific and Technical Information of China (English)

    Zhang Gang-Tai; Bai Ting-Ting; Zhang Mei-Guang

    2012-01-01

    We theoretically investigate high-order harmonic generation(HHG)from a helium ion model in a two-color laser field,which is synthesized by a fundamental pulse and its second harmonic pulse.It is shown that a supercontinuum spectrum can be generated in the two-color field.However,the spectral intensity is very low,limiting the application of the generated attosecond(as)pulse.By adding a static electric field to the synthesized two-color field,not only is the ionization yield of electrons contributing to the harmonic emission remarkably increased,but also the quantum paths of the HHG can be significantly modulated.As a result,the extension and enhancement of the supercontinuum spectrum are achieved,producing an intense isolated 26-as pulse with a bandwidth of about 170.5 eV.In particular,we also analyse the influence of the laser parameters on the ultrabroad supercontinuum spectrum and isolated sub-30-as pulse generation.

  11. Two-color above threshold ionization of atoms and ions in XUV Bessel beams and combined with intense laser light

    CERN Document Server

    Seipt, D; Surzhykov, A; Fritzsche, S

    2016-01-01

    The two-color above-threshold ionization (ATI) of atoms and ions is investigated for a vortex Bessel beam in the presence of a strong near-infrared (NIR) light field. While the photoionization is caused by the photons from the weak but extreme ultra-violet (XUV) vortex Bessel beam, the energy and angular distribution of the photoelectrons and their sideband structure are affected by the plane-wave NIR field. We here explore the energy spectra and angular emission of the photoelectrons in such two-color fields as a function of the size and location of the target (atoms) with regard to the beam axis. In addition, analogue to the circular dichroism in typical two-color ATI experiments with circularly polarized light, we define and discuss seven different dichroism signals for such vortex Bessel beams that arise from the various combinations of the orbital and spin angular momenta of the two light fields. For localized targets, it is found that these dichroism signals strongly depend on the size and position of t...

  12. K-causality coincides with stable causality

    OpenAIRE

    Minguzzi, E

    2008-01-01

    It is proven that K-causality coincides with stable causality, and that in a K-causal spacetime the relation K^+ coincides with the Seifert's relation. As a consequence the causal relation "the spacetime is strongly causal and the closure of the causal relation is transitive" stays between stable causality and causal continuity.

  13. From Mere Coincidences to Meaningful Discoveries

    Science.gov (United States)

    Griffiths, Thomas L.; Tenenbaum, Joshua B.

    2007-01-01

    People's reactions to coincidences are often cited as an illustration of the irrationality of human reasoning about chance. We argue that coincidences may be better understood in terms of rational statistical inference, based on their functional role in processes of causal discovery and theory revision. We present a formal definition of…

  14. An algorithm for automatic evaluation of the spot quality in two-color DNA microarray experiments

    Directory of Open Access Journals (Sweden)

    Barillot Emmanuel

    2005-12-01

    Full Text Available Abstract Background Although DNA microarray technologies are very powerful for the simultaneous quantitative characterization of thousands of genes, the quality of the obtained experimental data is often far from ideal. The measured microarrays images represent a regular collection of spots, and the intensity of light at each spot is proportional to the DNA copy number or to the expression level of the gene whose DNA clone is spotted. Spot quality control is an essential part of microarray image analysis, which must be carried out at the level of individual spot identification. The problem is difficult to formalize due to the diversity of instrumental and biological factors that can influence the result. Results For each spot we estimate the ratio of measured fluorescence intensities revealing differential gene expression or change in DNA copy numbers between the test and control samples. We also define a set of quality characteristics and a model for combining these characteristics into an overall spot quality value. We have developed a training procedure to evaluate the contribution of each individual characteristic in the overall quality. This procedure uses information available from replicated spots, located in the same array or over a set of replicated arrays. It is assumed that unspoiled replicated spots must have very close ratios, whereas poor spots yield greater diversity in the obtained ratio estimates. Conclusion The developed procedure provides an automatic tool to quantify spot quality and to identify different types of spot deficiency occurring in DNA microarray technology. Quality values assigned to each spot can be used either to eliminate spots or to weight contribution of each ratio estimate in follow-up analysis procedures.

  15. Stimulated emission pumping of NH in flames by using two-color resonant four-wave mixing

    Energy Technology Data Exchange (ETDEWEB)

    Radi, P.P.; Frey, H.M.; Mischler, B.; Tzannis, A.P.; Beaud, P.; Gerber, T. [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1997-06-01

    In this work we examine the analytical potential of two-color resonant four-wave mixing for the determination and characterization of trace elements in a combustion environment. Experimental results for NH in flames at atmospheric pressure are presented. The selectivity of the technique is used to simplify the Q-branch region of the (0-0)A{sup 3}{Pi}-X{sup 3}{Sigma} vibronic transition of NH. In addition, we demonstrate that the technique is sensitive to state changing collisions. (author) 2 figs., 5 refs.

  16. Enhanced harmonic generation and wave-mixing via two-color multiphoton excitation of atoms/molecules

    CERN Document Server

    Avetissian, H K; Mkrtchian, G F

    2016-01-01

    We consider harmonics generation and wave-mixing by two-color multi photon resonant excitation of three-level atoms/molecules in strong laser fields. The coherent part of the spectra corresponding to multicolor harmonics generation is investigated. The obtained analytical results on the basis of generalized rotating wave approximation are in a good agreement with numerical calculations. The results applied to the hydrogen atom and homonuclear diatomic molecular ion show that one can achieve efficient generation of moderately high multicolor harmonics via multiphoton resonant excitation by appropriate laser pulses.

  17. Efficient generation of isolated attosecond pulses with high beam-quality by two-color Bessel-Gauss beams

    CERN Document Server

    Wang, Zhe; Zhang, Qingbin; Wang, Shaoyi; Lu, Peixiang

    2011-01-01

    The generation of isolated attosecond pulses with high efficiency and high beam quality is essential for attosec- ond spectroscopy. We numerically investigate the supercontinuum generation in a neutral rare-gas medium driven by a two-color Bessel-Gauss beam. The results show that an efficient smooth supercontinuum in the plateau is obtained after propagation, and the spatial profile of the generated attosecond pulse is Gaussian-like with the divergence angle of 0.1 degree in the far field. This bright source with high beam quality is beneficial for detecting and controlling the microscopic processes on attosecond time scale.

  18. Sensitivity to coincidences and paranormal belief.

    Science.gov (United States)

    Hadlaczky, Gergö; Westerlund, Joakim

    2011-12-01

    Often it is difficult to find a natural explanation as to why a surprising coincidence occurs. In attempting to find one, people may be inclined to accept paranormal explanations. The objective of this study was to investigate whether people with a lower threshold for being surprised by coincidences have a greater propensity to become believers compared to those with a higher threshold. Participants were exposed to artificial coincidences, which were formally defined as less or more probable, and were asked to provide remarkability ratings. Paranormal belief was measured by the Australian Sheep-Goat Scale. An analysis of the remarkability ratings revealed a significant interaction effect between Sheep-Goat score and type of coincidence, suggesting that people with lower thresholds of surprise, when experiencing coincidences, harbor higher paranormal belief than those with a higher threshold. The theoretical aspects of these findings were discussed.

  19. Terahertz radiation driven by two-color laser pulses at near-relativistic intensities: Competition between photoionization and wakefield effects.

    Science.gov (United States)

    González de Alaiza Martínez, P; Davoine, X; Debayle, A; Gremillet, L; Bergé, L

    2016-06-03

    We numerically investigate terahertz (THz) pulse generation by linearly-polarized, two-color femtosecond laser pulses in highly-ionized argon. Major processes consist of tunneling photoionization and ponderomotive forces associated with transverse and longitudinal field excitations. By means of two-dimensional particle-in-cell (PIC) simulations, we reveal the importance of photocurrent mechanisms besides transverse and longitudinal plasma waves for laser intensities >10(15) W/cm(2). We demonstrate the following. (i) With two-color pulses, photoionization prevails in the generation of GV/m THz fields up to 10(17) W/cm(2) laser intensities and suddenly loses efficiency near the relativistic threshold, as the outermost electron shell of ionized Ar atoms has been fully depleted. (ii) PIC results can be explained by a one-dimensional Maxwell-fluid model and its semi-analytical solutions, offering the first unified description of the main THz sources created in plasmas. (iii) The THz power emitted outside the plasma channel mostly originates from the transverse currents.

  20. Laser-induced periodic surface structures on titanium upon single- and two-color femtosecond double-pulse irradiation.

    Science.gov (United States)

    Höhm, Sandra; Rosenfeld, Arkadi; Krüger, Jörg; Bonse, Jörn

    2015-10-05

    Single- and two-color double-fs-pulse experiments were performed on titanium to study the dynamics of the formation of laser-induced periodic surface structures (LIPSS). A Mach-Zehnder inter-ferometer generated polarization controlled (parallel or cross-polarized) double-pulse sequences in two configurations - either at 800 nm only, or at 400 and 800 nm wavelengths. The inter-pulse delays of the individual 50-fs pulses ranged up to some tens of picoseconds. Multiple of these single- or two-color double-fs-pulse sequences were collinearly focused by a spherical mirror to the sample surface. In both experimental configurations, the peak fluence of each individual pulse was kept below its respective ablation threshold and only the joint action of both pulses lead to the formation of LIPSS. Their resulting characteristics were analyzed by scanning electron microscopy and the periods were quantified by Fourier analyses. The LIPSS periods along with the orientation allow a clear identification of the pulse which dominates the energy coupling to the material. A plasmonic model successfully explains the delay-dependence of the LIPSS on titanium and confirms the importance of the ultrafast energy deposition stage for LIPSS formation.

  1. Knot polynomial identities and quantum group coincidences

    CERN Document Server

    Morrison, Scott; Snyder, Noah

    2010-01-01

    We construct link invariants using the D_2n subfactor planar algebras, and use these to prove new identities relating certain specializations of colored Jones polynomials to specializations of other quantum knot polynomials. These identities can also be explained by coincidences between small modular categories involving the even parts of the D_2n planar algebras. We discuss the origins of these coincidences, explaining the role of SO level-rank duality, Kirby-Melvin symmetry, and properties of small Dynkin diagrams. One of these coincidences involves G_2 and does not appear to be related to level-rank duality.

  2. Obstruction Theory and Coincidences in Positive Codimension

    Institute of Scientific and Technical Information of China (English)

    Daciberg GON(C)ALVES; Jerzy JEZIERSKI; Peter WONG

    2006-01-01

    Let f, g: X → Y be two maps between closed manifolds with dim X ≥ dim Y = n ≥ 3.We study the primary obstruction on(f,g) to deforming f and g to be coincidence free on the n-th skeleton of X. We give examples for which obstructions to deforming f and g to be coincidence free are detected by on (f, g).

  3. Determining activities of radionuclides from coincidence signatures

    Science.gov (United States)

    Warren, Glen A.; Smith, L. Eric; Aalseth, Craig E.; Ellis, Edward; Hossbach, Todd W.; Valsan, Andrei B.

    2006-05-01

    The spectral analysis of simultaneously observed photons in separate detectors may provide an invaluable tool for radioisotope identification applications. A general recursive method to determine the activity of an isotope from the observed coincidence signature rate is discussed. The method coherently accounts for effects of true coincidence summing within a single detector and detection efficiencies. A verification of the approach with computer simulations is also discussed.

  4. Two-color light-emitting diodes with polarization-sensitive high extraction efficiency based on graphene

    Science.gov (United States)

    H, Sattarian; S, Shojaei; E, Darabi

    2016-05-01

    In the present study, graphene photonic crystals are employed to enhance the light extraction efficiency (LEE) of two-color, red and blue, light-emitting diode (LED). The transmission characteristics of one-dimensional (1D) Fibonacci graphene photonic crystal LED (FGPC-LED) are investigated by using the transfer matrix method and the scaling study is presented. We analyzed the influence of period, thickness, and permittivity in the structure to enhance the LEE. The transmission spectrum of 1D FGPC has been optimized in detail. In addition, the effects of the angle of incidence and the state of polarization are investigated. As the main result, we found the optimum values of relevant parameters to enhance the extraction of red and blue light from an LED as well as provide perfect omnidirectional and high peak transmission filters for the TE and TM modes.

  5. Formation of laser-induced periodic surface structures on fused silica upon two-color double-pulse irradiation

    Science.gov (United States)

    Höhm, S.; Herzlieb, M.; Rosenfeld, A.; Krüger, J.; Bonse, J.

    2013-12-01

    The formation of laser-induced periodic surface structures (LIPSS) upon irradiation of fused silica with multiple irradiation sequences consisting of laser pulse pairs (50 fs single-pulse duration) of two different wavelengths (400 and 800 nm) is studied experimentally. Parallel polarized double-pulse sequences with a variable delay Δt between -10 and +10 ps and between the individual fs-laser pulses were used to investigate the LIPSS periods versus Δt. These two-color experiments reveal the importance of the ultrafast energy deposition to the silica surface by the first laser pulse for LIPSS formation. The second laser pulse subsequently reinforces the previously seeded spatial LIPSS frequencies.

  6. Formation of laser-induced periodic surface structures on fused silica upon two-color double-pulse irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Höhm, S.; Herzlieb, M.; Rosenfeld, A. [Max-Born-Institut für Nichtlineare Optik und Kurzzeitspektroskopie (MBI), Max-Born-Straße 2A, D-12489 Berlin (Germany); Krüger, J.; Bonse, J. [BAM Bundesanstalt für Materialforschung und –prüfung, Unter den Eichen 87, D-12205 Berlin (Germany)

    2013-12-16

    The formation of laser-induced periodic surface structures (LIPSS) upon irradiation of fused silica with multiple irradiation sequences consisting of laser pulse pairs (50 fs single-pulse duration) of two different wavelengths (400 and 800 nm) is studied experimentally. Parallel polarized double-pulse sequences with a variable delay Δt between −10 and +10 ps and between the individual fs-laser pulses were used to investigate the LIPSS periods versus Δt. These two-color experiments reveal the importance of the ultrafast energy deposition to the silica surface by the first laser pulse for LIPSS formation. The second laser pulse subsequently reinforces the previously seeded spatial LIPSS frequencies.

  7. The research on two-color photon sources in infrared and X-ray ranges by compton scattering

    CERN Document Server

    Yu Zhao

    2001-01-01

    The generation of a two-color source of FEL light in both the infrared and soft X-ray ranges by intracavity Compton backscattering is demonstrated by the Beijing FEL facility. 1.20-1.35 keV soft X-rays are successfully extracted from the optical cavity of the FEL through a porous metallic mirror, while a 9-10 mu m FEL laser is output in the other dielectric mirror simultaneously. The average output flux of X-ray is 10 sup 2 -10 sup 3 photons/s when the average output FEL laser power is 6-20 mW. The experimental result allows us to envision a convenient way to expand the application areas of IR FEL facilities into X-ray or gamma-ray ranges.

  8. Ultrafast molecular photoionization by two-color orthogonally polarized ultraviolet laser pulses: Effects of relative pulse phases

    Science.gov (United States)

    Yuan, Kai-Jun; Chelkowski, Szczepan; Bandrauk, André D.

    2017-09-01

    We present molecular photoionization by two-color 2ω1 =ω2 orthogonally polarized ultraviolet laser pulses. Simulations are performed on aligned H+ by numerically solving time-dependent Schrödinger equations. Two ionization processes with one ω2 photon interfering with two ω1 photon absorption are studied at different molecular alignments. Molecular frame photoelectron momentum and angular distributions exhibit asymmetries which are functions of the relative pulse phase. For resonant excitation processes by the ω1 pulse, symmetric distributions are obtained. An attosecond ionization model is adopted to describe the ultrafast ionization dynamics. The dependence of the ionization asymmetry on the molecular alignment allows to further monitor interference effects on orbital symmetry.

  9. Simultaneous measurement of temperature and velocity of air flow over 1000°C using two color phosphor thermometry

    Science.gov (United States)

    Fukuta, Masatoshi; Someya, Satoshi; Munakata, Tetsuo; LCS Team

    2016-11-01

    Thermal barrier coatings were applied to the gas turbines and the internal combustion engines for the high thermal efficiency. The evaluation and the improvement of coatings require to measure transient gaseous flow near the wall with coatings. An aim of this study is to combine a two color phosphor thermometry with the PIV to measure simultaneously temperature and velocity of the gas over 1000°C. The temperature and velocity distribution of an impinging jet of high temperature air was simultaneously visualized in experiments. The temperature was estimated from an intensity ratio of luminescent in different ranges of wavelength, 500 600 nm and 400 480 nm. Uncertainty of measured temperature was less than 10°C. Temperatures measured by the developed method and by thermocouples were agreed well. The measured velocity by the PIV with phosphor particles were also agreed well with the velocity measured by a Laser Doppler Velocimeter.

  10. Simulation of triple coincidences in PET.

    Science.gov (United States)

    Cal-González, J; Lage, E; Herranz, E; Vicente, E; Udias, J M; Moore, S C; Park, M-A; Dave, S R; Parot, V; Herraiz, J L

    2015-01-07

    Although current PET scanners are designed and optimized to detect double coincidence events, there is a significant amount of triple coincidences in any PET acquisition. Triple coincidences may arise from causes such as: inter-detector scatter (IDS), random triple interactions (RT), or the detection of prompt gamma rays in coincidence with annihilation photons when non-pure positron-emitting radionuclides are used (β(+)γ events). Depending on the data acquisition settings of the PET scanner, these triple events are discarded or processed as a set of double coincidences if the energy of the three detected events is within the scanner's energy window. This latter option introduces noise in the data, as at most, only one of the possible lines-of-response defined by triple interactions corresponds to the line along which the decay occurred. Several novel works have pointed out the possibility of using triple events to increase the sensitivity of PET scanners or to expand PET imaging capabilities by allowing differentiation between radiotracers labeled with non-pure and pure positron-emitting radionuclides. In this work, we extended the Monte Carlo simulator PeneloPET to assess the proportion of triple coincidences in PET acquisitions and to evaluate their possible applications. We validated the results of the simulator against experimental data acquired with a modified version of a commercial preclinical PET/CT scanner, which was enabled to acquire and process triple-coincidence events. We used as figures of merit the energy spectra for double and triple coincidences and the triples-to-doubles ratio for different energy windows and radionuclides. After validation, the simulator was used to predict the relative quantity of triple-coincidence events in two clinical scanners assuming different acquisition settings. Good agreement between simulations and preclinical experiments was found, with differences below 10% for most of the observables considered. For clinical

  11. Two Color Entanglement

    CERN Document Server

    Samblowski, Aiko; Grosse, Nicolai; Lam, Ping Koy; Schnabel, Roman

    2010-01-01

    We report on the generation of entangled states of light between the wavelengths 810 and 1550 nm in the continuous variable regime. The fields were produced by type I optical parametric oscillation in a standing-wave cavity build around a periodically poled potassium titanyl phosphate crystal, operated above threshold. Balanced homodyne detection was used to detect the non-classical noise properties, while filter cavities provided the local oscillators by separating carrier fields from the entangled sidebands. We were able to obtain an inseparability of I=0.82, corresponding to about -0.86 dB of non-classical quadrature correlation.

  12. In Situ Measurement of Airway Surface Liquid [K+] Using a Ratioable K+-sensitive Fluorescent Dye*

    OpenAIRE

    Namkung, Wan; Song, Yuanlin; Mills, Aaron D.; Padmawar, Prashant; Finkbeiner, Walter E.; Verkman, A. S.

    2009-01-01

    The airway surface liquid (ASL) is the thin fluid layer lining airway surface epithelial cells, whose volume and composition are tightly regulated and may be abnormal in cystic fibrosis (CF). We synthesized a two-color fluorescent dextran to measure ASL [K+], TAC-Lime-dextran-TMR, consisting of a green-fluorescing triazacryptand K+ ionophore-Bodipy conjugate, coupled to dextran, together with a red fluorescing tetramethylrhodamine reference chromophore. TAC-Lime-dextran-TMR fluorescence was K...

  13. Setting confidence intervals in coincidence search analysis

    CERN Document Server

    Baggio, L; Baggio, Lucio; Prodi, Giovanni A.

    2003-01-01

    The main technique that has been used to estimate the rate of gravitational wave (gw) bursts is to search for coincidence among times of arrival of candidate events in different detectors. Coincidences are modeled as a (possibly non-stationary) random time series background with gw events embedded in it, at random times but constant average rate. It is critical to test whether the statistics of the coincidence counts is Poisson, because the counts in a single detector often are not. At some point a number of parameters are tuned to increase the chance of detection by reducing the expected background: source direction, epoch vetoes based on sensitivity, goodness-of-fit thresholds, etc. Therefore, the significance of the confidence intervals itself has to be renormalized. This review is an insight of the state-of-the-art methods employed in the recent search performed by the International Gravitational Event Collaboration for the worldwide network of resonant bar detectors.

  14. A Precise Analytic Delayed Coincidence Efficiency and Accidental Coincidence Rate Calculation

    CERN Document Server

    Yu, Jingyi; Chen, Shaomin

    2013-01-01

    In a delayed coincidence experiment, for example, the recent reactor neutrino oscillation experiments, a precise analytic determination of the delayed coincidence signal efficiency and the accidental coincidence background rate is important for the high accuracy measurement of the oscillation parameters and to understand systematic uncertainties associated with fluctuations in muon rate and random background rate. In this work, a data model is proposed to describe the full time sequence of all possible events on the live time axis. The acceptance of delayed coincidence signals, the rate of accidental backgrounds and other coincidence possibilities are calculated by assuming that all of the `net muons' are uniformly distributed on the live time axis. The intrinsic relative uncertainties in the event rates are at the $10^{-5}$ level for all combinations. The model and predictions are verified with a high statistics Monte Carlo study with a set of realistic parameters.

  15. Using Compton scattering for random coincidence rejection

    Science.gov (United States)

    Kolstein, M.; Chmeissani, M.

    2016-12-01

    The Voxel Imaging PET (VIP) project presents a new approach for the design of nuclear medicine imaging devices by using highly segmented pixel CdTe sensors. CdTe detectors can achieve an energy resolution of ≈ 1% FWHM at 511 keV and can be easily segmented into submillimeter sized voxels for optimal spatial resolution. These features help in rejecting a large part of the scattered events from the PET coincidence sample in order to obtain high quality images. Another contribution to the background are random events, i.e., hits caused by two independent gammas without a common origin. Given that 60% of 511 keV photons undergo Compton scattering in CdTe (i.e. 84% of all coincidence events have at least one Compton scattering gamma), we present a simulation study on the possibility to use the Compton scattering information of at least one of the coincident gammas within the detector to reject random coincidences. The idea uses the fact that if a gamma undergoes Compton scattering in the detector, it will cause two hits in the pixel detectors. The first hit corresponds to the Compton scattering process. The second hit shall correspond to the photoelectric absorption of the remaining energy of the gamma. With the energy deposition of the first hit, one can calculate the Compton scattering angle. By measuring the hit location of the coincident gamma, we can construct the geometric angle, under the assumption that both gammas come from the same origin. Using the difference between the Compton scattering angle and the geometric angle, random events can be rejected.

  16. Intramolecular triplet energy transfer via higher triplet excited state during stepwise two-color two-laser irradiation.

    Science.gov (United States)

    Oseki, Yosuke; Fujitsuka, Mamoru; Sakamoto, Masanori; Majima, Tetsuro

    2007-10-01

    We studied the energy transfer processes in the molecular array consisting of pyrene (Py), biphenyl (Ph2), and bisphthalimidethiophene (ImT), (Py-Ph2)2-ImT, during two-color two-laser flash photolysis (2-LFP). The first laser irradiation predominantly generates ImT in the lowest triplet excited state (ImT(T1)) because of the efficient singlet energy transfer from Py in the lowest singlet excited state to ImT and, then, intersystem crossing of ImT. ImT(T1) was excited to the higher triplet excited state (Tn) with the second laser irradiation. Then, the triplet energy was rapidly transferred to Py via a two-step triplet energy transfer (TET) process through Ph2. The efficient generation of Py(T1) was suggested from the nanosecond-picosecond 2-LFP. The back-TET from Py(T1) to ImT was observed for several tens of microseconds after the second laser irradiation. The estimated intramolecular TET rate from Py(T1) to ImT was as slow as 3.1 x 104 s-1. Hence, long-lived Py(T1) was selectively and efficiently produced during the 2-LFP.

  17. Ultrafast energy redistribution in C(60) fullerenes: a real time study by two-color femtosecond spectroscopy.

    Science.gov (United States)

    Shchatsinin, Ihar; Laarmann, Tim; Zhavoronkov, Nick; Schulz, Claus Peter; Hertel, Ingolf V

    2008-11-28

    Strong-field excitation and energy redistribution dynamics of C(60) fullerenes are studied by means of time-resolved mass spectrometry in a two-color femtosecond pump-probe setup. Resonant pre-excitation of the electronic system via the first dipole-allowed HOMO-->LUMO+1(t(1g)) (HOMO denotes highest occupied molecular orbital and LUMO denotes lowest unoccupied molecular orbital) transition with ultrashort 25 fs pulses at 399 nm of some 10(12) W cm(-2) results in a highly nonequilibrium distribution of excited electrons and vibrational modes in the neutral species. The subsequent coupling among the electronic and nuclear degrees of freedom is monitored by probing the system with time-delayed 27 fs pulses at 797 nm of some 10(13) W cm(-2). Direct information on the characteristic relaxation time is derived from the analysis of transient singly and multiply charged parent and fragment ion signals as a function of pump-probe delay and laser pulse intensity. The observed relaxation times tau(el) approximately 60-400 fs are attributed to different microcanonical ensembles prepared in the pre-excitation process and correspond to different total energy contents and energy sharing between electronic and vibrational degrees. The characteristic differences and trends allow one to extract a consistent picture for the formation dynamics of ions in different charge states and their fullerenelike fragments and give evidence to collective effects in multiple ionization such as plasmon-enhanced energy deposition.

  18. Stimulated Emission Pumping by Two-Color Resonant Four-Wave Mixing: Rotational Characterization of Vibrationally Excited HCO

    Energy Technology Data Exchange (ETDEWEB)

    Radi, P.P.; Tulej, M.; Knopp, G.; Beaud, P.; Gerber, T.

    2004-03-01

    Stimulated emission pumping by applying two-color resonant four-wave mixing is used to measure rotationally resolved spectra of the HCO (0,0,0) B {sup 2}A' - (0,3,1) X {sup 2}A' transition. The formyl radical is produced by photodissociation of formaldehyde at 31710.8 cm{sup -1} under thermalized conditions in a low pressure cell. In contrast to the highly congested one-color spectrum of HCO at room temperature, the doubleresonance method yields well isolated transitions which are assigned unambiguously due to intermediate level labeling. 89 rotational transitions have been assigned and yield accurate rotational constants for the vibrationally excited (0,3,1) band of the electronic ground state X {sup 2}A' of HCO. The determined rotational constant A = 25.84{+-}0.01 cm-1 is considerably higher than that for the vibrationless ground state and reflects the structural change due to excitation of the bending mode of the formyl radical. (author)

  19. Generation of attosecond x-ray pulses with a multi-cycle two-color ESASE scheme

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Y.; Huang, Z.; Ratner, D.; Bucksbaum, P.; /SLAC; Merdji, H.; /Saclay /SLAC

    2009-03-04

    Generation of attosecond x-ray pulses is attracting much attention within the x-ray free-electron laser (FEL) user community. Several schemes using extremely short laser pulses to manipulate the electron bunches have been proposed. In this paper, we extend the attosecond two-color ESASE scheme proposed by Zholents et al. to the long optical cycle regime using a second detuned laser and a tapered undulator. Both lasers can be about ten-optical-cycles long, with the second laser frequency detuned from the first to optimize the contrast between the central and side current spikes. A tapered undulator mitigates the degradation effect of the longitudinal space charge (LSC) force in the undulator and suppresses the FEL gain of all side current peaks. Simulations using the LCLS parameters show a single attosecond x-ray spike of {approx} 110 attoseconds can be produced. The second laser can also be detuned to coherently control the number of the side x-ray spikes and the length of the radiation pulse.

  20. Two-color vibrational, femtosecond, fully resonant electronically enhanced CARS (FREE-CARS) of gas-phase nitric oxide

    Science.gov (United States)

    Stauffer, Hans U.; Roy, Sukesh; Schmidt, Jacob B.; Wrzesinski, Paul J.; Gord, James R.

    2016-09-01

    A resonantly enhanced, two-color, femtosecond time-resolved coherent anti-Stokes Raman scattering (CARS) approach is demonstrated and used to explore the nature of the frequency- and time-dependent signals produced by gas-phase nitric oxide (NO). Through careful selection of the input pulse wavelengths, this fully resonant electronically enhanced CARS (FREE-CARS) scheme allows rovibronic-state-resolved observation of time-dependent rovibrational wavepackets propagating on the vibrationally excited ground-state potential energy surface of this diatomic species. Despite the use of broadband, ultrafast time-resolved input pulses, high spectral resolution of gas-phase rovibronic transitions is observed in the FREE-CARS signal, dictated by the electronic dephasing timescales of these states. Analysis and computational simulation of the time-dependent spectra observed as a function of pump-Stokes and Stokes-probe delays provide insight into the rotationally resolved wavepacket motion observed on the excited-state and vibrationally excited ground-state potential energy surfaces of NO, respectively.

  1. Coincidence velocity map imaging using a single detector

    Science.gov (United States)

    Zhao, Arthur; Sándor, Péter; Weinacht, Thomas

    2017-07-01

    We demonstrate a single-detector velocity map imaging setup which is capable of rapidly switching between coincidence and non-coincidence measurements. By rapidly switching the extraction voltages on the electrostatic lenses, both electrons and ions can be collected in coincidence with a single detector. Using a fast camera as the 2D detector avoids the saturation problem associated with traditional delay line detectors and allows for easy transitions between coincidence and non-coincidence data collection modes. This is a major advantage in setting up a low-cost and versatile coincidence apparatus. We present both coincidence and non-coincidence measurements of strong field atomic and molecular ionization.

  2. Characterization of the 1 ^5Πu - 1 ^5Πg Band of C_2 by Two-Color Resonant Four-Wave Mixing and Lif

    Science.gov (United States)

    Radi, Peter

    2015-06-01

    The application of two-color resonant four-wave mixing (TC-RFWM) in combination with a discharge slit-source in a molecular beam environment is advantageous for the study of perturbations in C_2. Initial investigations have shown the potential of the method by a detailed deperturbation of the d3Π_g, v=4 state. The deperturbation of the d3Π_g, v=6 state unveiled the presence of the energetically lowest high-spin state of C_2. This dark state gains transition strength through the perturbation process with the d3Π_g, v=6 state yielding weak spectral features that are observable by the high sensitivity of the TC-RFWM technique. The successful deperturbation study of the d3Π_g, v=6 state resulted in the spectroscopic characterization of the quintet (15Πg) and an additional triplet state (d3Π_g, v=19). More recently, investigations have been performed by applying unfolded TC-RFWM to obtain further information on the quintet manifold. The first high-spin transition (15Πu) - 15Πg)) has been observed via an intermediate ``gateway'' state exhibiting both substantial triplet and quintet character owing to the perturbation between the 15Πg), v=0 and the d3Π_g, v=6 states. The high-lying quintet state is found to be predissociative and displays a shallow potential that accommodates three vibrational levels only. Further studies of the high-spin system will be presented in this contribution. By applying TC-RFWM and laser-induced fluorescence, data on the vibrational structure of the 15Πu - 15Πg system is obtained. The results are combined with high-level ab initio computations at the multi-reference configuration interaction (MRCI) level of theory and the largest possible basis currently implemented in the 2012 version of MOLPRO. P. Bornhauser, G. Knopp, T. Gerber, and P.P. Radi, Journal of Molecular Spectroscopy 262, 69 (2010) P. Bornhauser, Y. Sych, G. Knopp, T. Gerber, and P.P. Radi, Journal of Chemical Physics 134, 044302 (2011) Bornhauser, P., Marquardt, R

  3. Grain-boundary structures in hexagonal materials: Coincident and near coincident grain boundaries

    Energy Technology Data Exchange (ETDEWEB)

    Farkas, D. (Virginia Polytechnic Inst. and State Univ., Blacksburg, VA (United States). Dept. of Materials Science and Engineering)

    1994-07-01

    Embedded atom method (EAM) simulations of the structure of grain boundaries in hexagonal metal, are presented. The simulations use recently developed interatomic potentials for Ti and Co. Structures were calculated for various symmetrical tilt boundaries with the [1,100] tilt axis. The structures obtained for both metals are very similar. The energies for the Co boundaries are higher than those for Ti by a factor of 2. The structural unit model was applied to the computed grain-boundary structures in these hexagonal materials. As in cubic materials, the structural unit model can describe a series of symmetrical tilt coincident boundaries. In addition, when the coincidence ratio in the grain-boundary plane varies with the c/a ratio, a structural unit-type model can describe the variation of grain-boundary structure with c/a ratio. This model is adequate for describing series of symmetrical tilt boundaries with the grain-boundary plane oriented perpendicular to a fixed crystallographic direction and varying c/a ratios. For the structures of the so-called near coincident boundaries that appear in these materials, it was concluded that near coincident boundaries behave similarly to exact coincidence boundaries if there is a coincident periodic structure in the grain-boundary plane. This may occur even without a three-dimensional (3-D) coincident site lattice.

  4. Kinematical coincidence method in transfer reactions

    Energy Technology Data Exchange (ETDEWEB)

    Acosta, L.; Amorini, F. [INFN—Laboratori Nazionali del Sud, Via S. Sofia, Catania (Italy); Auditore, L. [INFN Gruppo Collegato di Messina and Dipartimento di Fisica, Università di Messina (Italy); Berceanu, I. [Institute for Physics and Nuclear Engineering, Bucharest (Romania); Cardella, G., E-mail: cardella@ct.infn.it [INFN—Sezione di Catania, Via S. Sofia, 95123 Catania (Italy); Chatterjiee, M.B. [Saha Institute for Nuclear Physics, Kolkata (India); De Filippo, E. [INFN—Sezione di Catania, Via S. Sofia, 95123 Catania (Italy); Francalanza, L.; Gianì, R. [INFN—Laboratori Nazionali del Sud, Via S. Sofia, Catania (Italy); Dipartimento di Fisica e Astronomia, Università di Catania, Via S. Sofia, Catania (Italy); Grassi, L. [INFN—Sezione di Catania, Via S. Sofia, 95123 Catania (Italy); Rudjer Boskovic Institute, Zagreb (Croatia); Grzeszczuk, A. [Institut of Physics, University of Silesia, Katowice (Poland); La Guidara, E. [INFN—Sezione di Catania, Via S. Sofia, 95123 Catania (Italy); Centro Siciliano di Fisica Nucleare e Struttura della Materia, Catania (Italy); Lanzalone, G. [INFN—Laboratori Nazionali del Sud, Via S. Sofia, Catania (Italy); Facoltà di Ingegneria e Architettura, Università Kore, Enna (Italy); Lombardo, I. [INFN—Laboratori Nazionali del Sud, Via S. Sofia, Catania (Italy); Dipartimento di Scienze Fisiche, Università Federico II and INFN Sezione di Napoli (Italy); Loria, D.; Minniti, T. [INFN Gruppo Collegato di Messina and Dipartimento di Fisica, Università di Messina (Italy); Pagano, E.V. [INFN—Laboratori Nazionali del Sud, Via S. Sofia, Catania (Italy); Dipartimento di Fisica e Astronomia, Università di Catania, Via S. Sofia, Catania (Italy); and others

    2013-07-01

    A new method to extract high resolution angular distributions from kinematical coincidence measurements in binary reactions is presented. Kinematics is used to extract the center of mass angular distribution from the measured energy spectrum of light particles. Results obtained in the case of {sup 10}Be+p→{sup 9}Be+d reaction measured with the CHIMERA detector are shown. An angular resolution of few degrees in the center of mass is obtained. The range of applicability of the method is discussed.

  5. Two-color femtosecond experiments by use of two independently tunable Ti:sapphire lasers with a sample-and-hold switch.

    Science.gov (United States)

    Sohn, J Y; Ahn, Y H; Yee, K J; Kim, D S

    1999-09-20

    We performed femtosecond two-color experiments (four-wave mixing and pump probe) using two independently tunable, partially synchronized femtosecond lasers. Despite the fact that the jitter is of the order of 5-10 ps, the time resolution is limited only by the pulse width when a homemade sample-and-hold switch is used.

  6. The effect of frequency chirping on electron-positron pair production in the one- and two-color laser pulse fields

    CERN Document Server

    Abdukerim, Nuriman; Xie, Bai-Song

    2016-01-01

    The effect of the frequency chirping on momentum spectrum and pair production rate in one- and two-color laser pulse fields is investigated by solving the quantum Vlasov equation. A small frequency chirp shifts the momentum spectrum along the momentum axis. The positive and negative frequency chirp parameters play the same role in increasing the pair number density. The sign change of frequency chirp parameter at the moment $t=0$ leads pulse shape and momentum spectrum to be symmetric, and the number density to be increased. The number density of produced pairs in the two-color pulse field is much higher than that in the one-color pulse field and the larger frequency chirp pulse field dominates more strongly. In the two-color pulse fields, the relation between the frequency ratio of two colors and the number density is not sensitive to the parameters of small frequency chirp added in either low frequency strong field or high frequency weak field but sensitive to the parameters of large frequency chirp added i...

  7. The 2 1Ag state of isolated cis-trans-1,3,5,7-octatetraene: two-color resonance enhanced two-photon ionization studies

    NARCIS (Netherlands)

    B.E. Kohler; T. Shaler; W.J. Buma

    1992-01-01

    Vibrationally resolved 1 1Ag2 1Ag excitation spectra and decay times for cis,trans-1,3,5,7-octatetraene seeded in a supersonic He expansion have been measured by two-color resonance enhanced two-photon ionization spectroscopy. The excitation energy of the 1 1Ag2 1Ag 0-0 band (29 035 cm-1 ) is ~6500

  8. A method for coincidence timing resolution enhancement

    Science.gov (United States)

    Ermis, E. E.; Celiktas, C.; Pilicer, E.

    2016-05-01

    A method including the coincidence time resolution improvement for a TOF/positron emission tomography system was suggested. The spectrometer for this aim was composed of two NaI(Tl) and two plastic scintillation detectors. Experimental results were supported by FLUKA Monte Carlo simulation program by constructing the detector setup in software medium. Present experimental results verified our previous results and conclusions obtained from the suggested method. It was concluded that better resolutions would help the improvement not only on the TOF gain but also on the spatial resolution, leading to better images and helping the Physician in his/her diagnosis and treatment.

  9. EDGE3: A web-based solution for management and analysis of Agilent two color microarray experiments

    Directory of Open Access Journals (Sweden)

    Craven Mark

    2009-09-01

    Full Text Available Abstract Background The ability to generate transcriptional data on the scale of entire genomes has been a boon both in the improvement of biological understanding and in the amount of data generated. The latter, the amount of data generated, has implications when it comes to effective storage, analysis and sharing of these data. A number of software tools have been developed to store, analyze, and share microarray data. However, a majority of these tools do not offer all of these features nor do they specifically target the commonly used two color Agilent DNA microarray platform. Thus, the motivating factor for the development of EDGE3 was to incorporate the storage, analysis and sharing of microarray data in a manner that would provide a means for research groups to collaborate on Agilent-based microarray experiments without a large investment in software-related expenditures or extensive training of end-users. Results EDGE3 has been developed with two major functions in mind. The first function is to provide a workflow process for the generation of microarray data by a research laboratory or a microarray facility. The second is to store, analyze, and share microarray data in a manner that doesn't require complicated software. To satisfy the first function, EDGE3 has been developed as a means to establish a well defined experimental workflow and information system for microarray generation. To satisfy the second function, the software application utilized as the user interface of EDGE3 is a web browser. Within the web browser, a user is able to access the entire functionality, including, but not limited to, the ability to perform a number of bioinformatics based analyses, collaborate between research groups through a user-based security model, and access to the raw data files and quality control files generated by the software used to extract the signals from an array image. Conclusion Here, we present EDGE3, an open-source, web

  10. A coincidence detection system based on real-time software

    Science.gov (United States)

    Ayuso, Sindulfo; José Blanco, Juan; Medina, José; Gómez-Herrero, Raúl; García-Población, Oscar; García Tejedor, Ignacio

    2016-09-01

    Conventional real-time coincidence systems use electronic circuitry to detect coincident pulses (hardware coincidence). In this work, a new concept of coincidence system based on real-time software (software coincidence) is presented. This system is based on the recurrent supervision of the analogue-to-digital converters status, which is described in detail. A prototype has been designed and built using a low-cost development platform. It has been applied to two different experimental sets for cosmic ray muon detection. Experimental muon measurements recorded simultaneously using conventional hardware coincidence and our software coincidence system have been compared, yielding identical results. These measurements have also been validated using simultaneous neutron monitor observations. This new software coincidence system provides remarkable advantages such as higher simplicity of interconnection and adjusting. Thus, our system replaces, at least, three Nuclear Instrument Modules (NIMs) required by conventional coincidence systems, reducing its cost by a factor of 40 and eliminating pulse delay adjustments.

  11. Monte Carlo calculations of the neutron coincidence gate utilisation factor for passive neutron coincidence counting

    CERN Document Server

    Bourva, L C A

    1999-01-01

    The general purpose neutron-photon-electron Monte Carlo N-Particle code, MCNP sup T sup M , has been used to simulate the neutronic characteristics of the on-site laboratory passive neutron coincidence counter to be installed, under Euratom Safeguards Directorate supervision, at the Sellafield reprocessing plant in Cumbria, UK. This detector is part of a series of nondestructive assay instruments to be installed for the accurate determination of the plutonium content of nuclear materials. The present work focuses on one aspect of this task, namely, the accurate calculation of the coincidence gate utilisation factor. This parameter is an important term in the interpretative model used to analyse the passive neutron coincidence count data acquired using pulse train deconvolution electronics based on the shift register technique. It accounts for the limited proportion of neutrons detected within the time interval for which the electronics gate is open. The Monte Carlo code MCF, presented in this work, represents...

  12. Measurement of accidental coincidences in beta-gamma coincidence counting using non-equal dead times

    CERN Document Server

    Hwang, H Y; Cho, Y H; Byun, J I; Kim, T S; Park, T S; Lee, J M

    2002-01-01

    It is shown that the multi-channel time-scaling (MCTS) method is particularly suitable for the direct measurement of accidental coincidences even if the dead times of the two counting channels are of different length. We prepared five samples, with activities from 900 to 2100 s sup - sup 1. The dead time of the gamma channel was 12 mu s for all measurements, but for the beta channel it varied from 12 to 20 mu s. The true coincidence rates determined by the MCTS method are compared with those obtained by using conventional technique.

  13. Spectral dynamics of THz pulses generated by two-color laser filaments in air: The role of Kerr nonlinearities and pump wavelength

    CERN Document Server

    Nguyen, A; Dechard, J; Thiele, I; Babushkin, I; Skupin, S; Berge, L

    2016-01-01

    We theoretically and numerically study the influence of both instantaneous and Raman-delayed Kerr nonlinearities as well as a long-wavelength pump in the terahertz (THz) emissions produced by two-color femtosecond filaments in air. Although the Raman-delayed nonlinearity induced by air molecules weakens THz generation, four-wave mixing is found to impact the THz spectra accumulated upon propagation via self-, cross-phase modulations and self-steepening. Besides, using the local current theory, we show that the scaling of laser-to-THz conversion efficiency with the fundamental laser wavelength strongly depends on the relative phase between the two colors, the pulse duration and shape, rendering a universal scaling law impossible. Scaling laws in powers of the pump wavelength may only provide a rough estimate of the increase in the THz yield. We confront these results with comprehensive numerical simulations of strongly focused pulses and of filaments propagating over meter-range distances.

  14. High harmonic generation in a two-color field composed of a pump field and a weak subsidiary high frequency field

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    “Coherent control of high-harmonic generation in a two-color field” has been widely concerned. Using split-operator algorithm, we have calculated the high-harmonic generation for helium ion He+ in a two-color field which is composed of a driving field and a weak subsidiary high frequency field (Is=I0/100, (ω,13ω), …(ω, 120ω)) and found that such a field can produce much higher harmonic intensity, typically increasing the harmonics corresponding to the incident frequency of the subsidiary field. The different effects coming from the different subsidiary fields are calculated and analyzed. It is indicated that one of the important underlying mechanisms is high frequency photon induced radiation.

  15. Silicon isotope separation utilizing infrared multiphoton dissociation of Si{sub 2}F{sub 6} irradiated with two-color CO{sub 2} laser light

    Energy Technology Data Exchange (ETDEWEB)

    Yokoyama, Atsushi; Ohba, Hironori; Hashimoto, Masashi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Ishii, Takeshi; Ohya, Akio [Nuclear Development Corp., Tokai, Ibaraki (Japan); Arai, Shigeyoshi [Hill Research Co. Ltd., Tokyo (Japan)

    2002-08-01

    Silicon isotope separation has been done by utilizing the Infrared Multiphoton Dissociation (IRMPD) of Si{sub 2}F{sub 6} irradiated with two-color CO{sub 2} laser lights. The two-color excitation method improved the separation efficiency keeping the high enrichment factors. For example, 99.74% of {sup 28}Si was obtained at 49.63% dissociation of Si{sub 2}F{sub 6} after the simultaneous irradiation of 200 pulses with 966.23 cm{sup -1} photons (0.084 J/cm{sup 2}) and 954.55 cm{sup -1} photons (0.658 J/cm{sup 2}), while 2000 pulses were needed to obtain 99.35% of {sup 28}Si at 35.6% dissociation in the case of only one-color irradiation at 954.55 cm{sup -1} (0.97 J/cm{sup 2}). (author)

  16. Two-color injection mould for the handle of egg mixer%鸡蛋搅拌机手柄双色注射模设计

    Institute of Scientific and Technical Information of China (English)

    陈罡; 陈乐平; 毛金明

    2012-01-01

    The structure layout, design points and working process of a two-color injection mould for the handle of an egg mixer were analyzed; and the design of gating system was presented in detail. The application of composite half-mechanism and mechanism of core-pulling by inclined ejector pin achieves sequential parting of the two-color mould.%分析了鸡蛋搅拌机手柄双色注射模的结构、设计要点和工作过程,详细介绍了模具浇注系统设计,采用复合哈夫机构和斜推杆内抽芯机构,实现了双色模具顺序分型动作.实践表明,模具结构可靠,运动平稳顺畅,制品精度和外观质量均符合要求.

  17. Fabry's disease and psychosis: causality or coincidence?

    Science.gov (United States)

    Gairing, S; Wiest, R; Metzler, S; Theodoridou, A; Hoff, P

    2011-01-01

    A 21-year-old female with Fabry's disease (FD) presented acute psychotic symptoms such as delusions, auditory hallucinations and formal thought disorders. Since the age of 14, she had suffered from various psychiatric symptoms increasing in frequency and intensity. We considered the differential diagnoses of prodromal symptoms of schizophrenia and organic schizophrenia-like disorder. Routine examinations including cognitive testing, electroencephalography and structural magnetic resonance imaging revealed no pathological findings. Additional structural and functional imaging demonstrated a minor CNS involvement of FD, yet without functional limitations. In summary our examination results support the thesis that in the case of our patient a mere coincidence of FD and psychotic symptoms is more likely than a causal connection.

  18. Dark energy, curvature and cosmic coincidence

    CERN Document Server

    Franca, U

    2006-01-01

    The fact that the energy densities of dark energy and matter are similar currently, known as the coincidence problem, is one of the main unsolved problems of cosmology. We present here a phenomenological model in which a spatial curvature of the universe can lead to a transition in the present epoch from a matter dominated universe to a scaling dark energy dominance in a very natural way. In particular, we show that if the exponential potential of the dark energy field depends linearly on the spatial curvature density of a closed universe, the observed values of some cosmological parameters can be obtained assuming acceptable values for the present spatial curvature of the universe, and without fine tuning in the only parameter of the model. We also comment on possible variations of this model.

  19. The Coincident Fission Fragment Detector (CFFD)

    Science.gov (United States)

    Wakhle, A.; Hammerton, K.; Kohley, Z.; Yurkon, J.; Stiefel, K.

    2017-08-01

    A Parallel Plate Avalanche Counter (PPAC) based fission detector system, called the Coincident Fission Fragment Detector (CFFD), has been developed for the ReA3 re-accelerator facility of the National Superconducting Cyclotron Laboratory (NSCL). Binary reaction kinematics are reconstructed based on position and time-of-flight measurements of fission fragments. Large area PPACs provide 1 ns level time resolution and mm level position resolution. The detectors allow measurements of fission product angular and mass distributions of heavy-ion induced fusion reactions. The 30 cm by 40 cm active area of each PPAC provides large solid angle coverage well suited for measurements of low intensity rare-isotope beams (RIBs).

  20. Dynamics of the formation of laser-induced periodic surface structures (LIPSS) upon femtosecond two-color double-pulse irradiation of metals, semiconductors, and dielectrics

    Energy Technology Data Exchange (ETDEWEB)

    Höhm, S.; Herzlieb, M.; Rosenfeld, A. [Max-Born-Institut für Nichtlineare Optik und Kurzzeitspektroskopie (MBI), Max-Born-Straße 2A, D-12489 Berlin (Germany); Krüger, J. [BAM Bundesanstalt für Materialforschung und –prüfung, Unter den Eichen 87, D-12205 Berlin (Germany); Bonse, J., E-mail: joern.bonse@bam.de [BAM Bundesanstalt für Materialforschung und –prüfung, Unter den Eichen 87, D-12205 Berlin (Germany)

    2016-06-30

    Graphical abstract: - Highlights: • LIPSS formation on Fused Silica, Silicon, and Titanium is studied upon parallel and cross-polarized two-color (400 and 800 nm) double-fs-pulse irradiation. • LIPSS orientation on Fused Silica follows the polarization of the first pulse. • LIPSS formation on Silicon and Titanium can be explained by a plasmonic model. - Abstract: In order to address the dynamics and physical mechanisms of LIPSS formation for three different classes of materials (metals, semiconductors, and dielectrics), two-color double-fs-pulse experiments were performed on Titanium, Silicon and Fused Silica. For that purpose a Mach–Zehnder interferometer generated polarization controlled (parallel or cross-polarized) double-pulse sequences at 400 nm and 800 nm wavelength, with inter-pulse delays up to a few picoseconds. Multiple of these two-color double-pulse sequences were collinearly focused by a spherical mirror to the sample surfaces. The fluence of each individual pulse (400 nm and 800 nm) was always kept below its respective ablation threshold and only the joint action of both pulses lead to the formation of LIPSS. Their resulting characteristics (periods, areas) were analyzed by scanning electron microscopy. The periods along with the LIPSS orientation allow a clear identification of the pulse which dominates the energy coupling to the material. For strong absorbing materials (Silicon, Titanium), a wavelength-dependent plasmonic mechanism can explain the delay-dependence of the LIPSS. In contrast, for dielectrics (Fused Silica) the first pulse always dominates the energy deposition and LIPSS orientation, supporting a non-plasmonic formation scenario. For all materials, these two-color experiments confirm the importance of the ultrafast energy deposition stage for LIPSS formation.

  1. How do we select multiple features? Transient costs for selecting two colors rather than one, persistent costs for color-location conjunctions.

    Science.gov (United States)

    Lo, Shih-Yu; Holcombe, Alex O

    2014-02-01

    In a previous study Lo, Howard, & Holcombe (Vision Research 63:20-33, 2012), selecting two colors did not induce a performance cost, relative to selecting one color. For example, requiring possible report of both a green and a red target did not yield a worse performance than when both targets were green. Yet a cost of selecting multiple colors was observed when selection needed be contingent on both color and location. When selecting a red target to the left and a green target to the right, superimposing a green distractor to the left and a red distractor to the right impeded performance. Possibly, participants cannot confine attention to a color at a particular location. As a result, distractors that share the target colors disrupt attentional selection of the targets. The attempt to select the targets must then be repeated, which increases the likelihood that the trial terminates when selection is not effective, even for long trials. Consistent with this, here we find a persistent cost of selecting two colors when the conjunction of color and location is needed, but the cost is confined to short exposure durations when the observer just has to monitor red and green stimuli without the need to use the location information. These results suggest that selecting two colors is time-consuming but effective, whereas selection of simultaneous conjunctions is never entirely successful.

  2. The Three-Color and Two-Color Tantrix(TM) Rotation Puzzle Problems are NP-Complete via Parsimonious Reductions

    CERN Document Server

    Baumeister, Dorothea

    2007-01-01

    Holzer and Holzer (Discrete Applied Mathematics 144(3):345--358, 2004) proved the Tantrix(TM) rotation puzzle problem with four colors NP-complete. Baumeister and Rothe (MCU 2007) modified their construction to achieve a parsimonious reduction from satisfiability to this problem. Since parsimonious reductions preserve the number of solutions, it follows that the unique version of the four-color Tantrix(TM) rotation puzzle problem is DP-complete under randomized reductions. In this paper, we study the three-color and the two-color Tantrix(TM) rotation puzzle problem. Restricting the number of allowed colors to three (respectively, to two) reduces the set of available Tantrix(TM) tiles from 56 to 14 (respectively, to 8). We prove that both the three-color and the two-color Tantrix(TM) rotation puzzle problem is NP-complete, which answers a question raised by Holzer and Holzer in the affirmative. Since both these reductions are parsimonious, it follows that both the unique three-color and the unique two-color Ta...

  3. Dynamics of the formation of laser-induced periodic surface structures (LIPSS) upon femtosecond two-color double-pulse irradiation of metals, semiconductors, and dielectrics

    Science.gov (United States)

    Höhm, S.; Herzlieb, M.; Rosenfeld, A.; Krüger, J.; Bonse, J.

    2016-06-01

    In order to address the dynamics and physical mechanisms of LIPSS formation for three different classes of materials (metals, semiconductors, and dielectrics), two-color double-fs-pulse experiments were performed on Titanium, Silicon and Fused Silica. For that purpose a Mach-Zehnder interferometer generated polarization controlled (parallel or cross-polarized) double-pulse sequences at 400 nm and 800 nm wavelength, with inter-pulse delays up to a few picoseconds. Multiple of these two-color double-pulse sequences were collinearly focused by a spherical mirror to the sample surfaces. The fluence of each individual pulse (400 nm and 800 nm) was always kept below its respective ablation threshold and only the joint action of both pulses lead to the formation of LIPSS. Their resulting characteristics (periods, areas) were analyzed by scanning electron microscopy. The periods along with the LIPSS orientation allow a clear identification of the pulse which dominates the energy coupling to the material. For strong absorbing materials (Silicon, Titanium), a wavelength-dependent plasmonic mechanism can explain the delay-dependence of the LIPSS. In contrast, for dielectrics (Fused Silica) the first pulse always dominates the energy deposition and LIPSS orientation, supporting a non-plasmonic formation scenario. For all materials, these two-color experiments confirm the importance of the ultrafast energy deposition stage for LIPSS formation.

  4. Laser-induced periodic surface structures on fused silica upon cross-polarized two-color double-fs-pulse irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Höhm, S., E-mail: hoehm@mbi-berlin.de.de [Max-Born-Institut für Nichtlineare Optik und Kurzzeitspektroskopie (MBI), Max-Born-Straße 2A, D-12489 Berlin (Germany); Herzlieb, M.; Rosenfeld, A. [Max-Born-Institut für Nichtlineare Optik und Kurzzeitspektroskopie (MBI), Max-Born-Straße 2A, D-12489 Berlin (Germany); Krüger, J. [BAM Bundesanstalt für Materialforschung und–prüfung, Unter den Eichen 87, D-12205 Berlin (Germany); Bonse, J., E-mail: joern.bonse@bam.de [BAM Bundesanstalt für Materialforschung und–prüfung, Unter den Eichen 87, D-12205 Berlin (Germany)

    2015-05-01

    Graphical abstract: - Highlights: • LIPSS formation on fused silica is studied upon cross-polarized two-color (400 and 800 nm) double-fs-pulse irradiation. • LIPSS orientation follows the polarization of the first pulse. • LIPSS periods are determined by the wavelength of the first pulse. • LIPSS area is increased for temporally overlapping pulses due to nonlinear absorption. - Abstract: The dynamics of the formation of laser-induced periodic surface structures (LIPSS) on fused silica upon irradiation with linearly polarized fs-laser pulses (50 fs pulse duration) is studied by cross-polarized two-color double-fs-pulse experiments. In order to analyze the relevance of temporally distributed energy deposition in the early stage of LIPSS formation, a Mach-Zehnder interferometer was used for generating multiple double-pulse sequences at two different wavelengths (400 and 800 nm). The inter-pulse delay between the individual cross-polarized pulses of each sequence was systematically varied in the sub-ps range and the resulting LIPSS morphologies were characterized by scanning electron microscopy. It is found that the polarization of the first laser pulse arriving to the surface determines the orientation and the periodicity of the LIPSS. These two-color experiments further confirm the importance of the ultrafast energy deposition to the silica surface for LIPSS formation, particularly by the first laser pulse of each sequence. The second laser pulse subsequently reinforces the previously seeded spatial LIPSS characteristics (period, orientation)

  5. New coincidence between Shroud of Turin and Sudarium of Oviedo

    Directory of Open Access Journals (Sweden)

    Barta C.

    2015-01-01

    Full Text Available The Sudarium of Oviedo and the Shroud of Turin are two relics attributed to Jesus Christ that show a series of amazing coincidences announced in the past. In this contribution, we describe the X-ray fluorescence analysis carried out on the Sudarium. Among the chemical elements detected, calcium shows a statistically significant higher presence in the areas with bloody stains. This fact allows correlating its distribution with the anatomical features of the corpse. A large excess of calcium is observed close to the tip of the nose. It is atypical to find soil dirt in this zone of the anatomy, but it is just the same zone where a particular presence of dust was found in the Shroud. The very low concentration of strontium traces in the Sudarium matches also well with the type of limestone characteristic of the rock of Calvary in Jerusalem. This new finding adds to others recently released and it strengthens the tradition that both cloths have wrapped the body of Jesus of Nazareth.

  6. A triterpene oleanolic acid conjugate with 3-hydroxyflavone derivative as a new membrane probe with two-color ratiometric response.

    Science.gov (United States)

    Turkmen, Zeynep; Klymchenko, Andrey S; Oncul, Sule; Duportail, Guy; Topcu, Gulacti; Demchenko, Alexander P

    2005-07-29

    We report on the synthesis by coupling of a triterpenoid oleanolic acid with 4'-diethylamino-3-hydroxyflavone (FE) to produce an environment-sensitive biomembrane probe with two-band ratiometric response in fluorescence emission. The synthesized compound (probe FOT) was tested in a series of model solvents and demonstrated the response to solvent polarity and intermolecular hydrogen bonding very similar to that of parent probe FE. Meantime when incorporated into lipid bilayer membranes, it showed new features differing in response between lipids of different surface charges as well as between glycerophospholipids and sphingomyelin. We observed that in the conditions of coexistence of rafts and non-raft structures the probe is excluded from the rafts.

  7. Near Threshold Coincident Electrofission of Uranium -238.

    Science.gov (United States)

    Dowell, David Harry

    Using the 100% duty cycle electron beam from the University of Illinois MUSL-2 accelerator, inelastic electron scattering form factors have been measured in coincidence with the fission decay of ('238)U. Data was taken at effective elastic momentum transfers of .36, .41 .45 and .59 fm(' -1) and electron-fission fragment angular correlations were measured perpendicular to and along the momentum transfer axis. The beam energies used were 67.11, 56.91 and 46.49 MeV, with the outgoing electron detected at 60(DEGREES) and 80(DEGREES), relative to the beam direction. The electron energy resolution was .1% and the form factors were measured for excitation energies from 2 to 12 MeV. Thin films of scintillator plastic (.5 mg/cm('2)) were used to detect the fission fragments from a 1 mg/cm('2) UF(,4) target evaporated onto a .240 mg/cm('2) aluminum backing. A prominent, anisotropic threshold peak is seen in the coincident form factors. An analysis of the q-dependence of the data and of the angular correlation indicates the observed strength is E2. Fission threshold for this E2 strength is about 5.7 MeV as compared with 6 MeV for E1 decays. The peak itself is due to the onset of neutron competition at 6.15 MeV. The threshold region, when analyzed using a Gaussian K-distribution to describe the statistical density of K -states near the fission barrier, exhibits a step-like change in the value of K(,0)('2) at .7 MeV above threshold. This indicates a possible energy gap in the E2 transition states. The decay is isotropic above 7.5 MeV excitation energy. From 7 to 11.7 MeV, the distribution of E2/EO strength is relatively flat with the total strength in this region exhausting approximately 10% of an energy weighted sum rule. A comparison with hadron scattering experiments suggests that some of the strength near 11.5 MeV is due to the fission decay of the giant monopole resonance with a fission probability similar to that of E2 transitions.

  8. Complex Action Support from Coincidences of Couplings

    CERN Document Server

    Nielsen, Holger Bech

    2011-01-01

    The model of Ninomiya and myself of complex action in a functional integral formulation interpreted by means of path integrals extending over all times, both past and future, is reviewed. A few numerical relations between coupling constants and masses are taken as supporting evidences. The new one such supporting ev- idence among the mentioned "coincidences" is that our model is able to explain (suggestively) that a) the Higgs field expectation value is very small ("scale problem") compared to say some fundamental scale that might be the Planck scale, b) This Higgs VEV scale need not be just zero, but rather is predicted to be so that the running top-quark Yukawa coupling just is about unity at this scale. In this way it is easily becoming an "exponentially" small scale. Instead of the top-Yukawa we should rather here say the highest flavour Yukawa coupling. These predictions are only achieved by allowing the principle of minimization of the imaginary part of the action SI(history) to to a certain extent adju...

  9. A folded-sandwich polarization-entangled two-color photon pair source with large tuning capability for applications in hybrid quantum architectures

    CERN Document Server

    Dietz, Otto; Kreißl, Thomas; Herzog, Ulrike; Kroh, Tim; Ahlrichs, Andreas; Benson, Oliver

    2015-01-01

    We demonstrate a two-color entangled pho ton pair source which can be adapted easily to a wide range of wavelengths combinations. A Fresnel rhomb as a geometrical quarter-wave plate and a versatile combination of compensation crystals are key components of the source. Entanglement of two photons at the Cs D1 line (894.3 nm) and at the telecom O-band (1313.1 nm) with a fidelity of $F = 0.753 \\pm 0.021$ is demonstrated and improvements of the setup are discussed.

  10. Neutron coincidence counting with digital signal processing

    Energy Technology Data Exchange (ETDEWEB)

    Bagi, Janos [Institute of Isotopes (IKI)-Budapest (Hungary); Dechamp, Luc; Dransart, Pascal; Dzbikowicz, Zdzislaw [European Commission, Joint Research Centre, IPSC-Ispra, VA (Italy); Dufour, Jean-Luc [Institut de Radioprotection et Surete Nucleaire-Fontenay-aux-Roses (France); Holzleitner, Ludwig [European Commission, Joint Research Centre, IPSC-Ispra (Italy); Huszti, Joseph [Institute of Isotopes (IKI)-Budapest (Hungary); Looman, Marc [Consulenze Tecniche-Cocquio Trevisago (Italy); Marin Ferrer, Montserrat [European Commission, Joint Research Centre, IPSC-Ispra (Italy); Lambert, Thierry [Institut de Radioprotection et Surete Nucleaire-Fontenay-aux-Roses (France); Peerani, Paolo [European Commission, Joint Research Centre, IPSC-Ispra (Italy)], E-mail: paolo.peerani@jrc.it; Rackham, Jamie [VT Nuclear Services-Sellafield, Seascale (United Kingdom); Swinhoe, Martyn; Tobin, Steve [N-1, Safeguards Science and Technology Group, LANL-Los Alamos, NM (United States); Weber, Anne-Laure [Institut de Radioprotection et Surete Nucleaire-Fontenay-aux-Roses (France); Wilson, Mark [VT Nuclear Services-Sellafield, Seascale (United Kingdom)

    2009-09-11

    Neutron coincidence counting is a widely adopted nondestructive assay (NDA) technique used in nuclear safeguards to measure the mass of nuclear material in samples. Nowadays, most neutron-counting systems are based on the original-shift-register technology, like the (ordinary or multiplicity) Shift-Register Analyser. The analogue signal from the He-3 tubes is processed by an amplifier/single channel analyser (SCA) producing a train of TTL pulses that are fed into an electronic unit that performs the time- correlation analysis. Following the suggestion of the main inspection authorities (IAEA, Euratom and the French Ministry of Industry), several research laboratories have started to study and develop prototypes of neutron-counting systems with PC-based processing. Collaboration in this field among JRC, IRSN and LANL has been established within the framework of the ESARDA-NDA working group. Joint testing campaigns have been performed in the JRC PERLA laboratory, using different equipment provided by the three partners. One area of development is the use of high-speed PCs and pulse acquisition electronics that provide a time stamp (LIST-Mode Acquisition) for every digital pulse. The time stamp data can be processed directly during acquisition or saved on a hard disk. The latter method has the advantage that measurement data can be analysed with different values for parameters like predelay and gate width, without repeating the acquisition. Other useful diagnostic information, such as die-away time and dead time, can also be extracted from this stored data. A second area is the development of 'virtual instruments.' These devices, in which the pulse-processing system can be embedded in the neutron counter itself and sends counting data to a PC, can give increased data-acquisition speeds. Either or both of these developments could give rise to the next generation of instrumentation for improved practical neutron-correlation measurements. The paper will

  11. Development of a coincidence system for the measurement of X-ray emission atomic parameters

    Energy Technology Data Exchange (ETDEWEB)

    Martinez, Filiberto; Miranda, Javier [Instituto de Fisica, Universidad Nacional Autonoma de Mexico, Apartado Postal 20-364, 01000 Mexico, D.F (Mexico)

    2013-07-03

    Preliminary results obtained in experiments carried out with an x-ray spectrometer built at the Instituto de Fisica for Atomic Physics and environmental sciences studies are presented. The experiments are based on a coincidence method for signals produced by LEGe and Si(Li) detectors. The x-ray fluorescence yields ({omega}{sub Li}) and Coster-Kronig transition probabilities (f{sub ij}) for elements with 55 {<=} Z {<=} 60 are among the quantities of interest. The method is based on the simultaneous detection of K x-rays with the LEGe detector and the L x-rays with the Si(Li) detector. The primary radiation source is an x-ray tube with Rh anode. The system was tested with the coincidence of the L x-rays from Ce with its K line, demonstrating the feasibility of the experiments.

  12. Fluorescence spectroscopy

    DEFF Research Database (Denmark)

    Bagatolli, Luis

    2016-01-01

    Fluorescence spectroscopy is a powerful experimental tool used by scientists from many disciplines. During the last decades there have been important developments on distinct fluorescence methods, particularly those related to the study of biological phenomena. This chapter discusses...

  13. Multi-Electron Coincidence Studies of Atoms and Molecules

    OpenAIRE

    Andersson, Egil

    2010-01-01

    This thesis concerns multi-ionization coincidence measurements of atoms and small molecules using a magnetic bottle time-of-flight (TOF) spectrometer designed for multi-electron coincidence studies. Also, a time-of-flight mass spectrometer has been used together with the TOF electron  spectrometer for electron-ion coincidence measurements. The multi-ionization processes have been studied by employing a pulsed discharge lamp in the vacuum ultraviolet spectral region and synchrotron radiation i...

  14. BOUNDS ON COINCIDENCE INDICES ON NON-ORIENTABLE SURFACES

    Institute of Scientific and Technical Information of China (English)

    D.VENDR(U)SCOLO

    2005-01-01

    This paper presents some results about bounds for coincidence indices of Nielsen coincidence classes for maps between nonorientable surfaces. Denoting by Kn the nonorientable surface constructed by a connected sum of n torus with a Klein bottle,the author proves: (i) for pairs of maps between two Klein bottles or for pairs of maps from a Klein bottle to a surface Kn the coincidence class index is bounded. (ii) for pairs of maps from Kn to the Klein bottle the coincidence class index is unbounded.Other boundedness results are given for more technical conditions, including one for self maps.

  15. The spatial distribution in high-order harmonic generation of H2+ with different time delays of the two-color laser fields

    Science.gov (United States)

    Zhang, Jun; Pan, Xue-Fei; Du, Hui; Xu, Tong-Tong; Guo, Jing; Liu, Xue-Shen

    2017-01-01

    We theoretically investigate the high-order harmonic generation (HHG) and the spatial distribution in HHG of the H2+ molecule by introducing a time-delayed two-color laser field which consists of the mid-infrared and near-infrared laser field. For the different time delays of the two-color laser fields, the pulse shapes are changed which result in the variation of the electron recombined with the nuclei along the positive- or negative-z direction. When the time delay is 0 fs (1.34 fs), a smooth harmonic plateau from the electron recombined with the nuclei along the negative (positive)-z direction can be achieved. An isolated attosecond pulse with a duration of about 99 as is generated when the time delay is 1.34 fs. We perform the classical analysis which is consistent with the numerical results from the one-dimensional non-Born-Oppenheimer time dependent Schrödinger equation (TDSE). We also investigate emission time of harmonics in terms of a time-frequency analysis to further understand the underlying physical mechanism.

  16. P1-9: Relationship between Color Shifts in Land's Two-Color Method and Higher- and Lower-Level Visual Information

    Directory of Open Access Journals (Sweden)

    Saki Iwaida

    2012-10-01

    Full Text Available Land's two-color method gives rise to apparent full-color perception, even though only two colors (e.g., red and gray are used. Previous studies indicate that chromatic adaptation, color memory, and inductive effects contribute to the shifts of color perception from real to illusory colors (e.g., Kuriki, 2006 Vision Research 46 3055–3066. This paper investigates the relationship between the color shifts induced by Land images and the skewness of the luminance histogram. In Experiment 1, several Land images are created based on a yellow ball, and the magnitude of the color shifts of the images are measured. The results of Experiment 1 show a significant correlation between the magnitude of the color shifts and skewness, suggesting that skewness is critical for the color shifts. In Experiment 2, we test the hypothesis that color shifts depends on just skewness; the color shifts should be invariant even if the Land images are scrambled. However, the results of Experiment 2 demonstrate that scrambled Land images exhibit less intense color shifts, suggesting that color shifts are determined by the object's overall shape or surface gloss, not just skewness. Taken together, we conclude that both low-level visual processes, such as those associated with luminance histogram skew, and high-level cognitive functions, such as object interpretation or understanding of surface gloss, are involved in the color shift of Land images.

  17. Laser-induced periodic surface structures on fused silica upon cross-polarized two-color double-fs-pulse irradiation

    Science.gov (United States)

    Höhm, S.; Herzlieb, M.; Rosenfeld, A.; Krüger, J.; Bonse, J.

    2015-05-01

    The dynamics of the formation of laser-induced periodic surface structures (LIPSS) on fused silica upon irradiation with linearly polarized fs-laser pulses (50 fs pulse duration) is studied by cross-polarized two-color double-fs-pulse experiments. In order to analyze the relevance of temporally distributed energy deposition in the early stage of LIPSS formation, a Mach-Zehnder interferometer was used for generating multiple double-pulse sequences at two different wavelengths (400 and 800 nm). The inter-pulse delay between the individual cross-polarized pulses of each sequence was systematically varied in the sub-ps range and the resulting LIPSS morphologies were characterized by scanning electron microscopy. It is found that the polarization of the first laser pulse arriving to the surface determines the orientation and the periodicity of the LIPSS. These two-color experiments further confirm the importance of the ultrafast energy deposition to the silica surface for LIPSS formation, particularly by the first laser pulse of each sequence. The second laser pulse subsequently reinforces the previously seeded spatial LIPSS characteristics (period, orientation).

  18. Coincidence measurements in {alpha}/{beta}/{gamma} spectrometry with phoswich detectors using digital pulse shape discrimination analysis

    Energy Technology Data Exchange (ETDEWEB)

    Celis, B. de [University of Leon, Escuela de Ingenieria Industrial, Leon 24071 (Spain)], E-mail: bcelc@unileon.es; Fuente, R. de la [University of Leon, Escuela de Ingenieria Industrial, Leon 24071 (Spain); Williart, A. [UNED, F. Ciencias Fisicas, Madrid 28040 (Spain); Celis Alonso, B. de [King' s College London, IoP, De Crespigny Park, London SE5 8AF (United Kingdom)

    2007-09-21

    A novel system has been developed for the detection of low radioactivity levels using coincidence techniques. The device combines a phoswich detector for {alpha}/{beta}/{gamma} ray recognition with a fast digital card for electronic pulse analysis. The detector is able to discriminate different types of radiation in a mixed {alpha}/{beta}/{gamma} field and can be used in a coincidence mode by identifying the composite signal produced by the simultaneous detection of {beta} particles in a plastic scintillator and {gamma} rays in an NaI(Tl) scintillator. Use of a coincidence technique with phoswich detectors was proposed recently to verify the Nuclear Test Ban Treaty, which made it necessary to monitor the low levels of xenon radioisotopes produced by underground nuclear explosions. Previous studies have shown that combining CaF{sub 2}(Eu) for {beta} ray detection and NaI(Tl) for {gamma} ray detection makes it difficult to identify the coincidence signals because of the similar fluorescence decay times of the two scintillators. With the device proposed here, it is possible to identify the coincidence events owing to the short fluorescence decay time of the plastic scintillator. The sensitivity of the detector may be improved by employing liquid scintillators, which allow low radioactivity levels from actinides to be measured when present in environmental samples. The device developed is simpler to use than conventional coincidence equipment because it uses a single detector and electronic circuit, and it offers fast and precise analysis of the coincidence signals by employing digital pulse shape analysis.

  19. A pH-sensitive red fluorescent protein compatible with hydrophobic resin embedding

    Science.gov (United States)

    Guo, Wenyan; Gang, Yadong; Liu, Xiuli; Zhou, Hongfu; Zeng, Shaoqun

    2017-02-01

    pH sensitive fluorescent proteins enabling chemical reactivation in resin are useful tools for fluorescence microimaging. EYFP or EGFP improved from GFP in jellyfish are good for such applications. For simultaneous two-color imaging, a suitable red fluorescent protein is of urgent need. Here a pH sensitive red fluorescent protein, pHuji, is selected and verified to be compatible with hydrophobic resin embedding and thus may be promising for dual-colour chemical reactivation imaging in conjunction with EGFP or EYFP.

  20. An Inexpensive Coincidence Circuit for the Pasco Geiger Sensors

    CERN Document Server

    Fichera, F; Librizzi, F; Riggi, F

    2005-01-01

    A simple coincidence circuit was devised to carry out educational coincidence experiments involving the use of Geiger counters. The system was tested by commercially available Geiger sensors from PASCO, and is intended to be used in collaboration with high school students and teachers

  1. Coincidence Prompt Gamma-Ray Neutron Activation Analysis

    Energy Technology Data Exchange (ETDEWEB)

    R.P. gandner; C.W. Mayo; W.A. Metwally; W. Zhang; W. Guo; A. Shehata

    2002-11-10

    The normal prompt gamma-ray neutron activation analysis for either bulk or small beam samples inherently has a small signal-to-noise (S/N) ratio due primarily to the neutron source being present while the sample signal is being obtained. Coincidence counting offers the possibility of greatly reducing or eliminating the noise generated by the neutron source. The present report presents our results to date on implementing the coincidence counting PGNAA approach. We conclude that coincidence PGNAA yields: (1) a larger signal-to-noise (S/N) ratio, (2) more information (and therefore better accuracy) from essentially the same experiment when sophisticated coincidence electronics are used that can yield singles and coincidences simultaneously, and (3) a reduced (one or two orders of magnitude) signal from essentially the same experiment. In future work we will concentrate on: (1) modifying the existing CEARPGS Monte Carlo code to incorporate coincidence counting, (2) obtaining coincidence schemes for 18 or 20 of the common elements in coal and cement, and (3) optimizing the design of a PGNAA coincidence system for the bulk analysis of coal.

  2. Shift-register coincidence electronics system for thermal neutron counters

    Energy Technology Data Exchange (ETDEWEB)

    Swansen, J.E.; Collinsworth, P.R.; Krick, M.S.

    1980-04-01

    An improved shift-register, coincidence-counting logic circuit, developed for use with thermal neutron well counters, is described in detail. A distinguishing feature of the circuit is its ability to operate usefully at neutron counting rates of several hundred kHz. A portable electronics package incorporating the new coincidence logic and support circuits is also described.

  3. Digital gamma-gamma coincidence HPGe system for environmental analysis

    DEFF Research Database (Denmark)

    Markovic, Nikola; Roos, Per; Nielsen, Sven Poul

    2017-01-01

    The performance of a new gamma-gamma coincidence spectrometer system for environmental samples analysis at the Center for Nuclear Technologies of the Technical University of Denmark (DTU) is reported. Nutech Coincidence Low Energy Germanium Sandwich (NUCLeGeS) system consists of two HPGe detector...

  4. Recovery and normalization of triple coincidences in PET

    Energy Technology Data Exchange (ETDEWEB)

    Lage, Eduardo, E-mail: elage@mit.edu; Parot, Vicente; Dave, Shivang R.; Herraiz, Joaquin L. [Madrid-MIT M+Visión Consortium, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States); Moore, Stephen C.; Sitek, Arkadiusz; Park, Mi-Ae [Division of Nuclear Medicine, Department of Radiology, Harvard Medical School and Brigham and Women’s Hospital, Boston, Massachusetts 02115 (United States); Udías, Jose M. [Grupo de Física Nuclear, Departamento de Física Atómica Molecular y Nuclear, Universidad Complutense de Madrid, CEI Moncloa, Madrid 28040 (Spain); Vaquero, Juan J. [Departamento de Ingeniería Biomédica e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Leganés 28911 (Spain)

    2015-03-15

    Purpose: Triple coincidences in positron emission tomography (PET) are events in which three γ-rays are detected simultaneously. These events, though potentially useful for enhancing the sensitivity of PET scanners, are discarded or processed without special consideration in current systems, because there is not a clear criterion for assigning them to a unique line-of-response (LOR). Methods proposed for recovering such events usually rely on the use of highly specialized detection systems, hampering general adoption, and/or are based on Compton-scatter kinematics and, consequently, are limited in accuracy by the energy resolution of standard PET detectors. In this work, the authors propose a simple and general solution for recovering triple coincidences, which does not require specialized detectors or additional energy resolution requirements. Methods: To recover triple coincidences, the authors’ method distributes such events among their possible LORs using the relative proportions of double coincidences in these LORs. The authors show analytically that this assignment scheme represents the maximum-likelihood solution for the triple-coincidence distribution problem. The PET component of a preclinical PET/CT scanner was adapted to enable the acquisition and processing of triple coincidences. Since the efficiencies for detecting double and triple events were found to be different throughout the scanner field-of-view, a normalization procedure specific for triple coincidences was also developed. The effect of including triple coincidences using their method was compared against the cases of equally weighting the triples among their possible LORs and discarding all the triple events. The authors used as figures of merit for this comparison sensitivity, noise-equivalent count (NEC) rates and image quality calculated as described in the NEMA NU-4 protocol for the assessment of preclinical PET scanners. Results: The addition of triple-coincidence events with the

  5. Mean and variance of coincidence counting with deadtime

    CERN Document Server

    Yu, D F

    2002-01-01

    We analyze the first and second moments of the coincidence-counting process for a system affected by paralyzable (extendable) deadtime with (possibly unequal) deadtimes in each singles channel. We consider both 'accidental' and 'genuine' coincidences, and derive exact analytical expressions for the first and second moments of the number of recorded coincidence events under various scenarios. The results include an exact form for the coincidence rate under the combined effects of decay, background, and deadtime. The analysis confirms that coincidence counts are not exactly Poisson, but suggests that the Poisson statistical model that is used for positron emission tomography image reconstruction is a reasonable approximation since the mean and variance are nearly equal.

  6. Roles for Coincidence Detection in Coding Amplitude-Modulated Sounds.

    Directory of Open Access Journals (Sweden)

    Go Ashida

    2016-06-01

    Full Text Available Many sensory neurons encode temporal information by detecting coincident arrivals of synaptic inputs. In the mammalian auditory brainstem, binaural neurons of the medial superior olive (MSO are known to act as coincidence detectors, whereas in the lateral superior olive (LSO roles of coincidence detection have remained unclear. LSO neurons receive excitatory and inhibitory inputs driven by ipsilateral and contralateral acoustic stimuli, respectively, and vary their output spike rates according to interaural level differences. In addition, LSO neurons are also sensitive to binaural phase differences of low-frequency tones and envelopes of amplitude-modulated (AM sounds. Previous physiological recordings in vivo found considerable variations in monaural AM-tuning across neurons. To investigate the underlying mechanisms of the observed temporal tuning properties of LSO and their sources of variability, we used a simple coincidence counting model and examined how specific parameters of coincidence detection affect monaural and binaural AM coding. Spike rates and phase-locking of evoked excitatory and spontaneous inhibitory inputs had only minor effects on LSO output to monaural AM inputs. In contrast, the coincidence threshold of the model neuron affected both the overall spike rates and the half-peak positions of the AM-tuning curve, whereas the width of the coincidence window merely influenced the output spike rates. The duration of the refractory period affected only the low-frequency portion of the monaural AM-tuning curve. Unlike monaural AM coding, temporal factors, such as the coincidence window and the effective duration of inhibition, played a major role in determining the trough positions of simulated binaural phase-response curves. In addition, empirically-observed level-dependence of binaural phase-coding was reproduced in the framework of our minimalistic coincidence counting model. These modeling results suggest that coincidence

  7. Atom waveguide and 1D optical lattice using a two-color evanescent light field around an optical micro/nano-fiber

    Institute of Scientific and Technical Information of China (English)

    Jian Fu; Xiang Yin; Ningyuan Li; Limin Tong

    2008-01-01

    We propose a two-color scheme of atom waveguides and one-dimensional(1D)optical lattices using evanescent wave fields of different transverse modes around an optical micro/nano-fiber.The atom guide potential can be produced when the optical fiber carries a red-detuned light with TE01 mode and a blue-detuned light with HE11 mode,and the 1D optical lattice potential can be produced when the red-detuned light is transformed to the superposition of the TE01 mode and HE11 mode.The two trapping potentials can be transformed to each other for accurately controlling mode transformation for the red-detuned light.This might provide a new approach to realize flexible transition between the guiding and trapping states of atoms.

  8. Pseudo-rephasing and pseudo-free-induction-decay mechanism in two-color three-pulse photon echo of a binary system.

    Science.gov (United States)

    Dong, Hui; Ryu, Ian Seungwan; Fleming, Graham R

    2013-12-27

    We investigate the two-color three-pulse photon echo peak shift in a (left-right) binary system, where each component consists of a heterodimer. On the basis of the model, we find that the effect of the excitonic asymmetry between two components leads to an additional factor in the peak shift. A pseudo-rephasing and pseudo-free-induction-decay mechanism is proposed to explain the resultant negative peak shift, when the differences between the two left/right components have the opposite sign. In such a case, estimates of the electronic coupling strength via two- and one-color peak shift experiments lead to an underestimate of the coupling magnitude.

  9. Comparison of soot formation for diesel and jet-a in a constant volume combustion chamber using two-color pyrometry

    KAUST Repository

    Jing, Wei

    2014-04-01

    The measurement of the two-color line of sight soot and KL factor for NO.2 diesel and jet-A fuels was conducted in an optical constant volume combustion chamber by using a high speed camera under 1000 K ambient temperature and varied oxygen concentration conditions. The ambient conditions were set as follows: four oxygen cases including 10%, 15%, 18% and 21% at 1000 K ambient temperature. KL factor and soot temperature were determined based on the two-color pyrometry technique using two band-pass filters with wavelengths of 650 nm and 550 nm. The results show that low soot temperature is observed in the upstream inner flame along the centerline, which is surrounded by high soot temperature regions, and a high KL factor is found in the same region with a low soot temperature. The results under different times suggest that soot temperature is higher for high O2 conditions during the entire flame development; meanwhile, both integrated KL factor and soot area decrease with the increase of O2 concentration. The two fuels share a similar trend of soot temperature and KL factor, however, diesel flame has a higher soot temperature and a larger high soot temperature area compared to jet-A flame. On the other hand, diesel flame shows a lower soot level during the quasi-steady state with a higher total soot level at the end of the combustion under low O2 conditions. A lower O2 concentration range from 10% to 15% is expected to have the possibility to achieve a simultaneous reduction of soot and NOx in sooting flames under the 1000 K ambient temperature condition. Copyright © 2014 SAE International.

  10. An easy-to-use practical method to measure coincidence in the flow cytometer--the case of platelet-granulocyte complex determination.

    Science.gov (United States)

    Bihari, Péter; Fent, János; Hamar, János; Furész, József; Lakatos, Susan

    2008-04-24

    Cell complexes composed of two different cells labeled with different fluorophores can be detected as double positive events in the flow cytometer. Double positivity can originate not only from real complexes but from non-interacting coinciding cells as well. Coincidence has a high impact on the determination of the amount of platelet-granulocyte complexes since platelet concentration is in the orders of magnitude higher than that of the granulocytes. Mixtures of non-interacting fluorescent beads as well as EDTA anticoagulated or citrated blood samples were analyzed in the flow cytometer in the presence and absence of fluorescent beads at various dilutions. Experimental data were evaluated by mathematical means. The bead or platelet concentration dependence of double positivity was converted into linear functions using Poisson distribution. This linearised form contains information on the detection volume as well as on the presence/absence of dilution independent complexes. The presence of appropriate fluorescent beads in the blood sample makes possible to estimate the fraction of double positivity originating from coincidence if data collection is triggered by the granulocytes or by the fluorescent beads, alternatively. Mixing fluorescent beads into a blood sample is a simple experimental method to distinguish double positivity originating from real cell-cell complexes from the coincidence of cells in a flow cytometer, thus providing a tool for the determination of the real amount of cell-cell complexes.

  11. Introduction to Neutron Coincidence Counter Design Based on Boron-10

    Energy Technology Data Exchange (ETDEWEB)

    Kouzes, Richard T.; Ely, James H.; Lintereur, Azaree T.; Siciliano, Edward R.

    2012-01-22

    The Department of Energy Office of Nonproliferation Policy (NA-241) is supporting the project 'Coincidence Counting With Boron-Based Alternative Neutron Detection Technology' at Pacific Northwest National Laboratory (PNNL) for development of an alternative neutron coincidence counter. The goal of this project is ultimately to design, build and demonstrate a boron-lined proportional tube based alternative system in the configuration of a coincidence counter. This report, providing background information for this project, is the deliverable under Task 1 of the project.

  12. Measurement of accidental coincidences for higher activity sources

    CERN Document Server

    Yull Hwang, H; Jae-Oh, P; Man-Lee, J; Kie-Lee, M

    1999-01-01

    The multi-channel time-scaling (MCTS) technique has been applied for the measurement of accidental coincidences for the cases of higher activity samples in beta-gamma coincidence counting. Two beta samples of sup 1 sup 3 sup 4 Cs were prepared and the nominal activities observed in the beta counter were about 7000 and 11000 s sup - sup 1 , respectively. The obtained true coincidence rates are independent of resolving times and dead times. They are compared with those calculated from the mathematical model derived by Cox and Isham.

  13. Why Do Deconfinement and Chiral Restoration Coincide at High Temperature?

    Institute of Scientific and Technical Information of China (English)

    杨树; 郭华; 赵恩广; 吕晓夫

    2004-01-01

    The global colour model in free space is extended to finite temperature to study the deconfinement and chiral phase transitions at high temperature T and zero chemical potential in the mean field approximation. Both possibilities of coincidence and non-coincidence of the two distinct phase transitions are found when the model parameters are varied in a certain range. The underlying mechanisms of the coincidence and noncoincidence are analysed and discussed. The validity of the T-dependent model propagator as the input is also discussed.

  14. 48-channel coincidence counting system for multiphoton experiment

    Science.gov (United States)

    Zhang, Chen; Li, Wei; Hu, Yi; Yang, Tao; Jin, Ge; Jiang, Xiao

    2016-11-01

    In this paper, we demonstrate a coincidence counting system with 48 input channels which is aimed to count all coincidence events, up to 531 441 kinds, in a multiphoton experiment. Using the dynamic delay adjusting inside the Field Programmable Gate Array, the alignment of photon signals of 48 channels is achieved. After the alignment, clock phase shifting is used to sample signal pulses. Logic constraints are used to stabilize the pulse width. The coincidence counting data stored in a 1G bit external random access memory will be sent to the computer to analyze the amount of 2-, 3-, 4-, 5-, and 6-fold coincidence events. This system is designed for multiphoton entanglement experiments with multiple degrees of freedom of photons.

  15. A coincidence theorem for holomorphic maps to G/P

    OpenAIRE

    Sankaran, Parameswaran

    2002-01-01

    We show that any two holomorhpic maps, not both of which are constant, from a generalized Hopf manifold to its base must have a coincidence. We prove a similar result for holomorphic maps from a generalized Calabi-Eckmann manifold.

  16. A digital coincidence measurement system using FPGA techniques

    Energy Technology Data Exchange (ETDEWEB)

    Zhu Fengming; Hsieh, S.C.; Yen, W.W. [Department of Engineering and System Science, National Tsing Hua University, Hsinchu, 30043, Taiwan (China); Chou, H.P., E-mail: hpc@ess.nthu.edu.tw [Department of Engineering and System Science, National Tsing Hua University, Hsinchu, 30043, Taiwan (China)

    2011-10-01

    A field programmable gate array (FPGA) based digital coincidence system has been developed to use with NaI scintillators for field applications. The analog output signal from the photomultiplier anode is directly transferred into digital signals by pulse height for pulse width conversion. The digital signal contains the energy and timing information of the radiation events. The pulse width is then measured by a vernier type of time-to-digital converter (TDC). The timing information of radiation events is recorded and analyzed by a coincidence unit. Both the TDC unit and the coincidence unit are implemented using a commercial available FPGA board. The measured data is then sent to a personal computer for spectrum display. Efficiency as well as energy calibration has been performed. The system showed a timing resolution about 13 ns and an energy resolution of 12% for 0.511 MeV annihilation gammas; it also successfully demonstrated the background rejection ability through coincidence measurement.

  17. Glycinergic inhibition tunes coincidence detection in the auditory brainstem.

    Science.gov (United States)

    Myoga, Michael H; Lehnert, Simon; Leibold, Christian; Felmy, Felix; Grothe, Benedikt

    2014-05-07

    Neurons in the medial superior olive (MSO) detect microsecond differences in the arrival time of sounds between the ears (interaural time differences or ITDs), a crucial binaural cue for sound localization. Synaptic inhibition has been implicated in tuning ITD sensitivity, but the cellular mechanisms underlying its influence on coincidence detection are debated. Here we determine the impact of inhibition on coincidence detection in adult Mongolian gerbil MSO brain slices by testing precise temporal integration of measured synaptic responses using conductance-clamp. We find that inhibition dynamically shifts the peak timing of excitation, depending on its relative arrival time, which in turn modulates the timing of best coincidence detection. Inhibitory control of coincidence detection timing is consistent with the diversity of ITD functions observed in vivo and is robust under physiologically relevant conditions. Our results provide strong evidence that temporal interactions between excitation and inhibition on microsecond timescales are critical for binaural processing.

  18. Computed neutron coincidence counting applied to passive waste assay

    Energy Technology Data Exchange (ETDEWEB)

    Bruggeman, M.; Baeten, P.; De Boeck, W.; Carchon, R. [Nuclear Research Centre, Mol (Belgium)

    1997-11-01

    Neutron coincidence counting applied for the passive assay of fissile material is generally realised with dedicated electronic circuits. This paper presents a software based neutron coincidence counting method with data acquisition via a commercial PC-based Time Interval Analyser (TIA). The TIA is used to measure and record all time intervals between successive pulses in the pulse train up to count-rates of 2 Mpulses/s. Software modules are then used to compute the coincidence count-rates and multiplicity related data. This computed neutron coincidence counting (CNCC) offers full access to all the time information contained in the pulse train. This paper will mainly concentrate on the application and advantages of CNCC for the non-destructive assay of waste. An advanced multiplicity selective Rossi-alpha method is presented and its implementation via CNCC demonstrated. 13 refs., 4 figs., 2 tabs.

  19. Coincidence rotations of the root lattice $A_4$

    CERN Document Server

    Baake, Michael; Heuer, Manuela; Zeiner, Peter

    2007-01-01

    The coincidence site lattices of the root lattice $A_4$ are considered, and the statistics of the corresponding coincidence rotations according to their indices is expressed in terms of a Dirichlet series generating function. This is possible via an embedding of $A_4$ into the icosian ring with its rich arithmetic structure, which recently (arXiv:math.MG/0702448) led to the classification of the similar sublattices of $A_4$.

  20. Electron-ion-ion coincidence experiments for photofragmentation of polyatomic molecules using pulsed electric fields: treatment of random coincidences

    CERN Document Server

    Pruemper, G

    2007-01-01

    In molecular photofragmentation processes by soft X-rays, a number of ionic fragments can be produced, each having a different abundance and correlation with the emitted electron kinetic energy. For investigating these fragmentation processes, electron-ion and electron-ion-ion coincidence experiments, in which the kinetic energy of electrons are analyzed using an electrostatic analyzer while the mass of the ions is analyzed using a pulsed electric field, are very powerful. For such measurements, however, the contribution of random coincidences is substantial and affects the data in a non-trivial way. Simple intuitive subtraction methods cannot be applied. In the present paper, we describe these electron-ion and electron-ion-ion coincidence experiments together with a subtraction method for the contribution from random coincidences. We provide a comprehensive set of equations for the data treatment, including equations for the calculation of error-bars. We demonstrate the method by applying it to the fragmenta...

  1. Terahertz Emission Dependence on the Fundamental Optical Intensity in Generating Terahertz Waves from Two-Color Laser-Induced Gas Plasma

    Institute of Scientific and Technical Information of China (English)

    DAI Hou-Mei; LIU Jin-Song

    2011-01-01

    A transient photocurrent model is used to explain terahertz ermission from gas plasma irritated by two-color laser pulses,with one the second harmonic of the other.Taking multiple degrees of ionization into account,the gas ionization process at different laser intensities from 1014 W/cm2 to 1015 W/cm2 is discussed.The results show that when Iω ≥ 6 × 1014 W/cm2,double ionization plays an important role in producing electrons.The corresponding terahertz spectra and waveforms are calculated,showing that increasing laser intensity can broaden the spectra to high frequencies and enhance the terahertz field.A promising method for generating terahertz (THz) waves involves emission from laser induced gas plasmas,which was first introduced hy Hamster et al.[1,2] By focusing laser femtosecond pulses with intensity greater than the thresholl for ionization of the gas molecules,one can obtain significant plasma formation.The ionized electrons will then accelerate by the lapser ponderomotive force,thus an electromagnetic pulse at THz frcqucncies can be produced.Since then,other plasma-based THz generation scheines have been proposed.L(o)ffler et al.,[3,4] applied an external dc bias to the plasma region,leading to an approximately one order of magnitude increase in the THz field strength.%A transient photocurrent model is used to explain terahertz emission from gas plasma irritated by two-color laser pulses, with one the second harmonic of the other. Taking multiple degrees of iom'xntion into account, the gas ionizntion process at different laser intensities from 1014 W/cm2 to 1015 W/cm2 is discussed. The results show that when /w > 6 X 1014 W/cin2, double ionization plays an important role in producing electrons. The corresponding terahertz spectra and waveforms are calculated, showing that increasing laser intensity can broaden the spectra to high frequencies and enhance the terahertz Geld.

  2. Unraveling the rat blood genome-wide transcriptome after oral administration of lavender oil by a two-color dye-swap DNA microarray approach

    Directory of Open Access Journals (Sweden)

    Motohide Hori

    2016-06-01

    Full Text Available Lavender oil (LO is a commonly used essential oil in aromatherapy as non-traditional medicine. With an aim to demonstrate LO effects on the body, we have recently established an animal model investigating the influence of orally administered LO in rat tissues, genome-wide. In this brief, we investigate the effect of LO ingestion in the blood of rat. Rats were administered LO at usual therapeutic dose (5 mg/kg in humans, and following collection of the venous blood from the heart and extraction of total RNA, the differentially expressed genes were screened using a 4 × 44-K whole-genome rat chip (Agilent microarray platform; Agilent Technologies, Palo Alto, CA, USA in conjunction with a two-color dye-swap approach. A total of 834 differentially expressed genes in the blood were identified: 362 up-regulated and 472 down-regulated. These genes were functionally categorized using bioinformatics tools. The gene expression inventory of rat blood transcriptome under LO, a first report, has been deposited into the Gene Expression Omnibus (GEO: GSE67499. The data will be a valuable resource in examining the effects of natural products, and which could also serve as a human model for further functional analysis and investigation.

  3. Element Selective Probe of the Ultra-Fast Magnetic Response to an Element Selective Excitation in Fe-Ni Compounds Using a Two-Color FEL Source

    Directory of Open Access Journals (Sweden)

    Eugenio Ferrari

    2017-01-01

    Full Text Available The potential of the two-color mode implemented at the FERMI free-electron laser (FEL source for pumping and probing selectively different atomic species has been demonstrated by time-resolved scattering experiments with permalloy (FeNi alloy and NiFe2O4 samples. We monitored the ultra-fast demagnetization of Ni induced by the pump FEL pulse, by tuning the linearly-polarized FEL probe pulse to the Ni-3p resonance and measuring the scattered intensity in the transverse magneto-optical Kerr effect geometry. The measurements were performed by varying the intensity of the FEL pump pulse, tuning its wavelength to and off of the Fe-3p resonance, and by spanning the FEL probe pulse delays across the 300–900 fs range. The obtained results have evidenced that for the case of NiFe2O4, there is a sensible difference in the magnetic response at the Ni site when the pump pulse causes electronic excitations at the Fe site.

  4. Control of time stability of scintillation spectrometer of delayed coincidences

    CERN Document Server

    Morozov, V A

    2002-01-01

    Paper describes a system to control time stability of a two-detector plastic scintillation spectrometer of three-dimensional coincides. A two-reference control system incorporates a light guide base delay optical line, two light diodes and a two-channel generator of nanosecond pulses. A distinguishing feature of the design system is application of one delay line to form both advance and delay time signal as to the real coincidences in the studied radioactive source. The designed system of control enables to measure periods of half-decay of nuclei excited states within 40-100 ns range ensuring control of position of coincidence curve gravity centers within 4 ps limits

  5. CDL, a Precise, Low-Cost Coincidence Detector Latch

    Directory of Open Access Journals (Sweden)

    Ralf Joost

    2015-12-01

    Full Text Available The electronic detection of the coincidence of two events is still a key ingredient for high-performance applications, such as Positron Emission Tomography and Quantum Optics. Such applications are demanding, since the precision of their calculations and thus their conclusions directly depend on the duration of the interval in which two events are considered coincidental. This paper proposes a new circuitry, called coincidence detector latch (CDL, which is derived from standard RS latches. The CDL has the following advantages: low complexity, fully synthesizable, and high scalability. Even in its simple implementation, it achieves a coincidence window width as short as 115 ps, which is more than 10 times better than that reported by recent research.

  6. Implications on the cosmic coincidence by a dynamical extrinsic curvature

    CERN Document Server

    Capistrano, A J S

    2015-01-01

    In this work, we apply the smooth deformation concept in order to obtain a modification of Friedmann equations. It is shown that the cosmic coincidence can be at least alleviated using the dynamical properties of the extrinsic curvature. We investigate the transition from nucleosynthesis to the coincidence era obtaining a very small variation of the ratio $r=\\frac{\\rho_{m}}{\\rho_{ext}}$, that compares the matter energy density to extrinsic energy density, compatible with the known behavior of the deceleration parameter. We also show that the calculated "equivalence" redshift matches the transition redshift from a deceleration to accelerated phase and the coincidence ceases to be. The dynamics on $r$ is also studied based on Hubble parameter observations as the latest Baryons Acoustic Oscillations/Cosmic Microwave Background Radiation (BAO/CMBR) + SNIa.

  7. The ZEPLIN-III Anti-Coincidence Veto Detector

    CERN Document Server

    Akimov, D Yu; Barnes, E J; Belov, V A; Burenkov, A A; Chepel, V; Currie, A; Edwards, B; Francis, V; Ghag, C; Hollingsworth, A; Horn, M; Kalmus, G E; Kobyakin, A S; Kovalenko, A G; Lebedenko, V N; Lindote, A; Lopes, M I; Lüscher, R; Lyons, K; Majewski, P; Murphy, A St J; Neves, F; Paling, S M; da Cunha, J Pinto; Preece, R; Quenby, J J; Reichhart, L; Scovell, P R; Solovov, V N; Smith, N J T; Smith, P F; Stekhanov, V N; Sumner, T J; Taylor, R; Thorne, C; Walker, R J

    2010-01-01

    The design, optimisation and construction of an anti-coincidence veto detector to complement the ZEPLIN-III direct dark matter search instrument is described. One tonne of plastic scintillator is arranged into 52 bars individually read out by photomultipliers and coupled to a gadolinium-loaded passive polypropylene shield. Particular attention has been paid to radiological content. The overall aim has been to achieve a veto detector of low threshold and high efficiency without the creation of additional background in ZEPLIN-III, all at a reasonable cost. Extensive experimental measurements of the components have been made, including radioactivity levels and performance characteristics. These have been used to inform a complete end-to-end Monte Carlo simulation that has then been used to calculate the expected performance of the new instrument, both operating alone and as an anti-coincidence detector for ZEPLIN-III. The veto device will be capable of rejecting over 65% of coincident nuclear recoil events from ...

  8. Non-coincident multi-wavelength emission absorption spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, L.E.

    1995-02-01

    An analysis is presented of the effect of noncoincident sampling on the measurement of atomic number density and temperature by multiwavelength emission absorption. The assumption is made that the two signals, emission and transmitted lamp, are time resolved but not coincident. The analysis demonstrates the validity of averages of such measurements despite fluctuations in temperature and optical depth. At potassium-seeded MHD conditions, the fluctuations introduce additional uncertainty into measurements of potassium atom number density and temperature but do not significantly bias the average results. Experimental measurements in the CFFF aerodynamic duct with coincident and noncoincident sampling support the analysis.

  9. Optical Bell-state analysis in the coincidence basis

    CERN Document Server

    Walborn, S P; Pádua, S; Monken, C H

    2003-01-01

    Many quantum information protocols require a Bell-state measurement of entangled systems. Most optical Bell-state measurements utilize two-photon interference at a beam splitter. By creating polarization-entangled photons with spontaneous parametric down-conversion using a first-order Hermite-Gaussian pump beam, we invert the usual interference behavior and perform an incomplete Bell-state measurement in the coincidence basis. We discuss the possibility of a complete Bell-state measurement in the coincidence basis using hyperentangled states [Phys. Rev. A, \\textbf{58}, R2623 (1998)].

  10. The spectrum of coincident entities with small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL diagnosed by cytology

    Directory of Open Access Journals (Sweden)

    Kastenbaum Hannah

    2010-01-01

    Full Text Available Background: The cytologic diagnosis of Small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL often relies on finding a small lymphoid population with the characteristic immunoprofile by ancillary testing. There are only a few reports of other processes identified with SLL/CLL. The aim of this study was to review the fine needle aspiration (FNA and touch prep (TP diagnoses of SLL/CLL in order to identify any coincident entities. Materials and Methods: We retrospectively reviewed all FNA and TP cytology cases between January 2005 and May 2009 with a diagnosis of SLL/CLL to determine the presence of any coincident process. Results: We identified 29 cases, including 23 FNAs and six TPs, from 23 patients. Ancillary studies were utilized in 97% of the cases, including flow cytometry (FC, 79%, immunohistochemistry (IHC, 55%, fluorescent in situ hybridization studies (24% and special stains (7%. Coincident entities were identified in nine cases (31% and included seven (28% neoplastic entities (Hodgkin lymphoma [HL], adenocarcinoma, squamous cell carcinoma, seminoma and two (7% non-neoplastic entities (infection and immunoglobulin containing cells. Six cases (21% suspicious for large cell transformation were also identified. Conclusion: In our review of SLL/CLL, coincident entities were present in 31% of the cases and included a spectrum of non-neoplastic and neoplastic processes. FC was the most frequently utilized ancillary test, but IHC provided important information by excluding a mantle cell lymphoma or confirming a coincident process. Thus, cytomorphologic evaluation in these patients is important due to the high risk of a coincident process that may not be apparent by FC alone and may require clinical management.

  11. A comparison of coincident GRACE and ICESat data over Antarctica

    NARCIS (Netherlands)

    Gunter, B.; Urban, T.; Riva, R.E.M.; Helsen, M.M.; Harpold, R.; Poole, S.; Nagel, P.; Schutz, B.; Tapley, B.

    2009-01-01

    In this study, we present a comparison of coincident GRACE and ICESat data over Antarctica. The analysis focused on the secular changes over a 4-year period spanning from 2003 to 2007, using the recently reprocessed and publicly available data sets for both missions. The results show that the two in

  12. Limb-nadir matching using non-coincident NO

    NARCIS (Netherlands)

    Adams, Cristen; Normand, Elise N.; McLinden, Chris A.; Bourassa, Adam E.; Lloyd, Nicholas D.; Degenstein, Douglas A.; Krotkov, Nickolay A.; Belmonte Rivas, Maria; Boersma, Folkert; Eskes, Henk

    2016-01-01

    A variant of the limb-nadir matching technique for deriving tropospheric NO2 columns is presented in which the stratospheric component of the NO2 slant column density (SCD) measured by the Ozone Monitoring Instrument (OMI) is removed using non-coincident profiles from the

  13. A {beta} - {gamma} coincidence; Metodo de coincidencias {beta} - {gamma}

    Energy Technology Data Exchange (ETDEWEB)

    Agullo, F.

    1960-07-01

    A {beta} - {gamma} coincidence method for absolute counting is given. The fundamental principles are revised and the experimental part is detailed. The results from {sup 1}98 Au irradiated in the JEN 1 Swimming pool reactor are given. The maximal accuracy is 1 per cent. (Author) 11 refs.

  14. Limb-nadir matching using non-coincident NO

    NARCIS (Netherlands)

    Adams, Cristen; Normand, Elise N.; McLinden, Chris A.; Bourassa, Adam E.; Lloyd, Nicholas D.; Degenstein, Douglas A.; Krotkov, Nickolay A.; Belmonte Rivas, Maria; Boersma, Folkert; Eskes, Henk

    2016-01-01

    A variant of the limb-nadir matching technique for deriving tropospheric NO2 columns is presented in which the stratospheric component of the NO2 slant column density (SCD) measured by the Ozone Monitoring Instrument (OMI) is removed using non-coincident profiles from the Op

  15. Coincident optima for two-facility Weber problems

    DEFF Research Database (Denmark)

    Juel, Henrik

    1983-01-01

    The location problem with two new facilities in continuous space is considered, with distance measured by arbitrary norms. Necessary and sufficient conditions for a proposed solution to be optimal are given for several cases. These cases include situations where the cost function...... is nondifferentiable because facilities coincide...

  16. Fluorescent microspheres

    Science.gov (United States)

    Rembaum, A.

    1978-01-01

    Latex particles with attached antibodies have potential biochemical and environmental applications. Human red blood cells and lymphocytes have been labeled with fluorescent microspheres by either direct or indirect immunological technique. Immunolatex spheres can also be used for detecting and localizing specific cell surface receptors. Hormones and toxins may also be bondable.

  17. Electron-ion-ion coincidence experiments for photofragmentation of polyatomic molecules using pulsed electric fields: Treatment of random coincidences

    Energy Technology Data Exchange (ETDEWEB)

    Pruemper, G. [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai 980 8577 (Japan)]. E-mail: pruemper@tagen.tohoku.ac.jp; Ueda, K. [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai 980 8577 (Japan)

    2007-05-01

    In molecular photofragmentation processes by soft X-rays, a number of ionic fragments can be produced, each having a different abundance and correlation with the kinetic energy of the emitted electron. For investigating these fragmentation processes, electron-ion and electron-ion-ion coincidence experiments, in which the kinetic energy of electrons are analyzed using an electrostatic analyzer while the mass of the ions is analyzed using a pulsed electric field, are very powerful. For such measurements, however, the contribution of random coincidences is substantial and affects the data in a non-trivial way. Simple intuitive subtraction methods cannot be applied. In the present paper, we describe these electron-ion and electron-ion-ion coincidence experiments together with a subtraction method for the contribution from random coincidences. We provide a comprehensive set of equations for the data treatment, including equations for the calculation of error-bars. We demonstrate the method by applying it to the fragmentation of free CF{sub 3}SF{sub 5} molecules.

  18. DAPI fluorescence in nuclei isolated from tumors.

    Science.gov (United States)

    Krishan, Awtar; Dandekar, Payal D

    2005-08-01

    In DNA histograms of some human solid tumors stained with nuclear isolation medium--4,6-diamidino-2-phenylindole dihydrochloride (NIM-DAPI), the coefficient of variation (CV) of the G0/G1 peak was broad, and in nuclear volume vs DNA scattergrams, a prominent slope was seen. To determine the cause for this, nuclei from frozen breast tumors were stained with NIM-DAPI and analyzed after dilution or resuspension in PBS. In two-color (blue vs red) analysis, most of the slope and broad CV was due to red fluorescence of nuclei stained with NIM-DAPI, which was reduced on dilution or resuspension in PBS, resulting in elimination of the slope and tightening of the CV.

  19. Using CHIMERA detector at LNS for gamma-particle coincidences

    Directory of Open Access Journals (Sweden)

    Cardella G.

    2016-01-01

    Full Text Available We have recently evaluated the quality of γ-ray angular distributions that can be extracted in particle-gamma coincidence measurements using the CHIMERA detector at LNS. γ-rays have been detected using the CsI(Tl detectors of the spherical part of the CHIMERA array. Very clean γ-rays angular distributions were extracted in reactions induced by different stable beams impinging on 12C thin targets. The results evidenced an effect of projectile spin flip on the γ-rays angular distributions. γ-particle coincidence measurements were also performed in reactions induced by neutron rich exotic beams produced through in-flight fragmentation at LNS. In recent experiments also the Farcos array was used to improve energy and angular resolution measurements of the detected charged particles. Results obtained with both stable and radioactive beams are reported.

  20. Data Acquisition System for Electron Energy Loss Coincident Spectrometers

    Institute of Scientific and Technical Information of China (English)

    Zhang Chi; Yu Xiaoqi; Yang Tao

    2005-01-01

    A Data Acquisition System (DAQ) for electron energy loss coincident spectrometers (EELCS) has been developed. The system is composed of a Multiplex Time-Digital Converter (TDC) that measures the flying time of positive and negative ions and a one-dimension positionsensitive detector that records the energy loss of scattering electrons. The experimental data are buffered in a first-in-first-out(FIFO) memory module, then transferred from the FIFO memory to PC by the USB interface. The DAQ system can record the flying time of several ions in one collision, and allows of different data collection modes. The system has been demonstrated at the Electron Energy Loss Coincident Spectrometers at the Laboratory of Atomic and Molecular Physics, USTC. A detail description of the whole system is given and experimental results shown.

  1. Coincidences between gravitational wave interferometers and high energy neutrino telescopes

    Energy Technology Data Exchange (ETDEWEB)

    Pradier, Thierry [Institut Pluridisciplinaire Hubert Curien (IPHC/DRS), University Louis-Pasteur, Strasbourg (France)], E-mail: pradier@in2p3.fr

    2009-04-11

    Sources of gravitational waves (GW) and emitters of high energy neutrinos (HE {nu}) both involve compact objects and matter moving at relativistic speeds. GW emission requires a departure from spherical symmetry, which is the case if clumps of matter are accreted around black holes or neutron stars, and ejected in relativistic jets, where neutrinos are believed to be produced. Both messengers interact weakly with the surrounding matter, hence point directly to the heart of the engines that power these emissions. Coincidences between GW interferometers (e.g. VIRGO) and HE {nu} telescopes (e.g. ANTARES) would then give a unique insight on the physics of the most powerful objects in the Universe. The possibility, observability and detectability for such GW/HE {nu} coincidences are analysed.

  2. Performance of an active well coincidence counter for HEU samples

    Energy Technology Data Exchange (ETDEWEB)

    Ferrari, Francesca, E-mail: fra.ferrari@gmail.co [European Commission, Joint Research Centre, Institute for the Protection and the Security of the Citizen (IPSC), 21020 Ispra (Italy); Peerani, Paolo, E-mail: paolo.peerani@jrc.i [European Commission, Joint Research Centre, Institute for the Protection and the Security of the Citizen (IPSC), 21020 Ispra (Italy)

    2010-10-15

    Neutron coincidence counting is the reference NDA technique used in nuclear safeguards to measure the mass of nuclear material in samples. For high-enriched uranium (HEU) samples active neutron interrogation is generally performed and the most common device used by nuclear inspectors is the Active Well Coincidence Counter (AWCC). Within her master thesis at the Polytechnic of Milan, the first author performed an intensive study on the characteristics and performances of the AWCC in order to assess the {sup 235}U mass in HEU oxide samples at the PERLA laboratory of JRC. The work has been summarised in this paper that starts with the optimisation of the use of AWCC for nuclear safeguards, describing the calibration procedure, reporting results of a series of verification measurements, summarising the performances that can be obtained with this instruments during inspections at fuel production plants and concluding with the discussion of uncertainties related to these measurements.

  3. Spatial coincidence modulates interaction between visual and somatosensory evoked potentials.

    Science.gov (United States)

    Schürmann, Martin; Kolev, Vasil; Menzel, Kristina; Yordanova, Juliana

    2002-05-07

    The time course of interaction between concurrently applied visual and somatosensory stimulation with respect to evoked potentials (EPs) was studied. Visual stimuli, either in the left or right hemifield, and electric stimuli to the left wrist were delivered either alone or simultaneously. Visual and somatosensory EPs were summed and compared to bimodal EPs (BiEP, response to actual combination of both modalities). Temporal coincidence of stimuli lead to sub-additive or over-additive amplitudes in BiEPs in several time windows between 75 and 275 ms. Additional effects of spatial coincidence (left wrist with left hemifield) were found between 75 and 300 ms and beyond 450 ms. These interaction effects hint at a temporo-spatial pattern of multiple brain areas participating in the process of multimodal integration.

  4. Subthreshold production of pions in coincidence with light particles

    Energy Technology Data Exchange (ETDEWEB)

    Barbera, R.; Badala, A.; Adorno, A.; Bonasera, A.; Di Toro, M.; Palmeri, A.; Pappalardo, G.S.; Riggi, F.; Russo, G. (Istituto Nazionale di Fisica Nucleare, Catania (Italy)); Bizard, G.; Durand, D.; Laville, J.L. (Caen Univ., 14 (France). Lab. de Physique Corpusculaire); Jin, G.M. (Grand Accelerateur National d' Ions Lourds (GANIL), 14 - Caen (France)); Rosato, E. (Naples Univ. (Italy). Dipt. di Scienze Fisiche Istituto Nazionale di Fisica Nucleare, Naples (Italy))

    1990-12-03

    He ions have been detected in coincidence with charged pions in the reaction {sup 16}O on {sup 27}Al at E{sub lab}=94 MeV/u. We analyse velocity spectra and cross-sections of He ions emitted in the angular range 4deg/150deg in coincidence with charged pions detected at 90deg. A two source emission mechanism of the helium particles and a pion statistical production from an equilibrated participant zone is stressed. The absolute yields at different angles are compared with results of a theoretical model for medium energy heavy ion reactions in the frame of a participant-spectator picture. A comparison of the pion energy spectra with Boltzmann-Nordheim-Vlasov calculations and a discussion on the time scale for pion emission is also presented. (orig.).

  5. A coincidence of addiction to "Kratom" and severe primary hypothyroidism.

    Science.gov (United States)

    Sheleg, Sergey V; Collins, Gregory B

    2011-12-01

    Here we present a case of a coincidence of addiction to "Kratom" (botanically known as Mitragyna speciosa Korth) and developed severe primary hypothyroidism. We are discussing a possibility that high dose of indole alkaloid mitragynine (the major alkaloid identified from "Kratom") might reduce the normal response of the thyroid gland to thyroid-stimulating hormone resulting in primary hypothyroidism. Further experimental investigations of mitragynine as a possible suppressor of thyroid gland function would be a matter of interest.

  6. Coincidence of cerebrovascular accident and silent myocardial infarction.

    Science.gov (United States)

    Badui, E; Estañol, B; Garcia-Rubi, D

    1982-11-01

    Although it is well known that a myocardial and a cerebral infarction may be coincident, the nature of this association is not clear. The problem is further complicated because the myocardial infarction may be silent. This is a report of 3 patients with cerebral infarct in whom a silent recent myocardial infarction was found. All patients with cerebrovascular disease should be screened for a possible myocardial lesion.

  7. A catalogue of ULX coincidences with FIRST radio sources

    CERN Document Server

    Sanchez-Sutil, J R; Martí, J; Garrido, J L; Pérez-Ramírez, D; Luque-Escamilla, P

    2006-01-01

    We search for ultra luminous X-ray source (ULXs) radio counterparts located in nearby galaxies in order to constrain their physical nature. Our work is based on a systematic cross-identification of the most recent and extensive available ULX catalogues and archival radio data. A catalogue of 70 positional coincidences is reported. Most of them are located within the galaxy nucleus. Among them, we find 11 new cases of non-nuclear ULX sources with possibly associated radio emission.

  8. Non-minimal quintessence: Dynamics and coincidence problem

    Indian Academy of Sciences (India)

    Fatimah Shojai; Ali Shojai

    2011-12-01

    Brans–Dicke scalar–tensor theory provides a conformal coupling of the scalar field with gravity in Einstein’s frame. This model is equivalent to an interacting quintessence in which dark matter is coupled to dark energy. This provides a natural mechanism to alleviate the coincidence problem. We investigate the dynamics of this model and show that it leads to comparable dark energy and dark matter densities today.

  9. Coincidence Theorems for Certain Classes of Hybrid Contractions

    Directory of Open Access Journals (Sweden)

    Singh SL

    2010-01-01

    Full Text Available Coincidence and fixed point theorems for a new class of hybrid contractions consisting of a pair of single-valued and multivalued maps on an arbitrary nonempty set with values in a metric space are proved. In addition, the existence of a common solution for certain class of functional equations arising in dynamic programming, under much weaker conditions are discussed. The results obtained here in generalize many well known results.

  10. Caristi Type Coincidence Point Theorem in Topological Spaces

    Directory of Open Access Journals (Sweden)

    Jiang Zhu

    2013-01-01

    Full Text Available A generalized Caristi type coincidence point theorem and its equivalences in the setting of topological spaces by using a kind of nonmetric type function are obtained. These results are used to establish variational principle and its equivalences in d-complete spaces, bornological vector space, seven kinds of completed quasi-semimetric spaces equipped with Q-functions, uniform spaces with q-distance, generating spaces of quasimetric family, and fuzzy metric spaces.

  11. 基于彩色CCD的双色与三色比色测温法比较研究%Comparative Study on Two-Color and Three-Color Colorimetric Temperature Measurement Based on Colored CCD

    Institute of Scientific and Technical Information of China (English)

    孙元; 彭小奇

    2015-01-01

    双色与三色比色测温是彩色CCD辐射测温常用方法。通过理论分析和实验研究,分别从测温动态范围和测温精度两方面对双色法和三色法进行了比较研究。研究发现,在光圈快门组合保持不变的条件下,选取红、绿双色进行比色测温具有较宽的测温动态范围;在对辐射体做灰体假设的情况下,三色测温方法具有更高的测温精度。提出了构建一种可切换测温方法的统一测温硬件平台,统一测温平台综合了双色法和三色法两者的优点,可同时满足更宽的测温动态范围和更高的测温精度的要求,应用灵活。%The two-color and three-color colorimetric temperature measurements are major methods of the colored CCD-based radiation thermometry. The dynamic range and temperature measurement accuracy of the two-color and three-color thermometry are analyzed and compared respectively. The theory analysis and experimental results show that the two-color thermometry using red-green colors has much wider dynamic range than the three-color thermome⁃try in the combination of an aperture and shutter. In the other hand,the three-color thermometry has higher accura⁃cy than the two-color method when the radiator is assumed as a gray-body. Finally,the general temperature measure⁃ment platform flexibly switching the two-color and the three-color thermometry is proposed. The measurement plat⁃form combines the advantages of the two-color and three-color thermometry,which meets the requirements of wide dynamic range and high measurement accuracy.

  12. Two color morphs of the pelagic yellow-bellied sea snake, Pelamis platura, from different locations of Costa Rica: snake venomics, toxicity, and neutralization by antivenom.

    Science.gov (United States)

    Lomonte, Bruno; Pla, Davinia; Sasa, Mahmood; Tsai, Wan-Chih; Solórzano, Alejandro; Ureña-Díaz, Juan Manuel; Fernández-Montes, María Laura; Mora-Obando, Diana; Sanz, Libia; Gutiérrez, José María; Calvete, Juan J

    2014-05-30

    the treatment of envenomations by this species. Integrative analyses of animal venoms that combine the power of proteomics (venomics) with the characterization of their functional and immunological properties are significantly expanding knowledge on these remarkable bioweapons, both from a basic and a medical perspective. Costa Rica harbors a unique population of the yellow-bellied sea snake, Pelamis platura, that is restricted to a fjord-like gulf (Golfo Dulce). This population differs markedly from oceanic populations found elsewhere along the Pacific coast of this country, by presenting a patternless bright yellow coloration, instead of the typical bicolored or tricolored pattern of this species. It has been suggested that the dominance of this yellow-morph in Golfo Dulce might reflect gene flow restrictions, caused by the oceanographic conditions at this location. The present study demonstrates that the remarkable phenotypic variation between the two color morphs inhabiting Golfo Dulce and Golfo de Papagayo, respectively, is not associated with differences in the expression of venom components, as shown by their conserved RP-HPLC profiles. Proteomic analysis revealed the relatively simple toxin composition of P. platura venom, which contains three predominant types of proteins: three-finger toxins (protein abundance: 49.9%), phospholipases A2 (32.9%), and cysteine-rich secretory proteins (9.1%), together with few minor components. Further, the involvement of these most abundant proteins in the toxic effects of the venom, and their cross-recognition and neutralization by a sea snake antivenom produced against the venom of Enhydrina schistosa, were analyzed. Copyright © 2014 Elsevier B.V. All rights reserved.

  13. "Color Timer" mice: visualization of neuronal differentiation with fluorescent proteins.

    Science.gov (United States)

    Kanki, Hiroaki; Shimabukuro, Marilia Kimie; Miyawaki, Atsushi; Okano, Hideyuki

    2010-02-02

    The molecular mechanisms governing the differentiation of neural stem cells (NSCs) into neuronal progenitor cells and finally into neurons are gradually being revealed. The lack of convenient means for real-time determination of the stages of differentiation of individual neural cells, however, has been hindering progress in elucidating the mechanisms. In order to be able to easily identify the stages of differentiation of neural cells, we have been attempting to establish a mouse system that would allow progression of neuronal differentiation to be visualized based on transitions between fluorescence colors by using a combination of mouse genetics and the ever-expanding repertoire of fluorescent proteins. In this study we report the initial version of such a mouse system, which we call "Color Timer." We first generated transgenic (Tg; nestin/KOr Tg) mice in which production of the fluorescent protein Kusabira-Orange (KOr) is controlled by the gene regulatory elements within the 2nd intronic enhancer of the nestin gene, which is a good marker for NSCs, so that NSCs would emit orange fluorescence upon excitation. We then confirmed by immunohistochemical and immunocytochemical analyses that the KOr fluorescence closely reflected the presence of the Nestin protein. We also confirmed by a neurosphere formation assay that the intensity of the KOr fluorescence correlated with "stemness" of the cell and it was possible to readily identify NSCs in the two neurogenic regions, namely the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle, in the brain of adult nestin/KOr Tg mice by the orange fluorescence they emitted. We then crossed nestin/KOr mice with doublecortin-enhanced Green Fluorescent Protein Tg mice, whose immature neurons emit green fluorescence upon excitation, and it was possible to visualize the progress of NSC-to-neuron differentiation by the transition between fluorescence colors from orange to green. This two-color initial

  14. Illumination-dependent changes in the intrinsic fluorescence of bacteriorhodopsin

    Science.gov (United States)

    Bogomolni, R. A.; Stubbs, L.; Lanyi, J. K.

    1978-01-01

    The paper describes the intrinsic UV fluorescence of bacteriorhodopsin in some detail and determines the changes during the rapid cyclic reaction following light flashes. The results suggest that several tryptophan residues are affected in the protein, among them one or more exposed to aqueous medium. The kinetics of the fluorescence changes coincide closely with events involving the retinal residue during the deprotonation and reprotonation of the Schiff base group.

  15. Two-color laser-induced incandescence and cavity ring-down spectroscopy for sensitive and quantitative imaging of soot and PAHs in flames

    Science.gov (United States)

    Schoemaecker Moreau, C.; Therssen, E.; Mercier, X.; Pauwels, J. F.; Desgroux, P.

    Laser-induced incandescence is a technique which enables the measurement of soot volume fractions. However, the laser-induced soot emission might be affected by a fluorescence background generally ascribed to the polycyclic aromatic hydrocarbon compounds (PAHs) present at the soot location. In this paper, spatially resolved distributions of PAH absorbance and soot are obtained in sooting diffusion flames. The original method developed here consists in comparing the emission distributions induced by two different laser wavelengths: (1) at 1064 nm emission signals are exempt from PAH fluorescence and (2) at 532 nm both soot incandescence and PAH emission contribute to the total signal. In addition, the absolute absorption coefficient of the PAH mixture is determined by comparing absorption measurements obtained by cavity ring-down spectroscopy (CRDS) at 1064 nm and 532 nm. The proposed method can provide highly sensitive 2D imaging of PAHs and soot using the fundamental and the second-harmonic frequencies of a single YAG laser. Finally, 2D distributions of PAH absorbance and soot volume fraction calibrated by CRDS are obtained in two diffusion flames, particularly in a very low-sooting flame exhibiting a maximum PAH absorbance of 6×10-4 cm-1 and a maximum soot volume fraction of 3 ppb only. The respective spatial distributions of PAHs and soot are shown to vary with the initial C/O ratio.

  16. High-level neutron coincidence counter maintenance manual

    Energy Technology Data Exchange (ETDEWEB)

    Swansen, J.; Collinsworth, P.

    1983-05-01

    High-level neutron coincidence counter operational (field) calibration and usage is well known. This manual makes explicit basic (shop) check-out, calibration, and testing of new units and is a guide for repair of failed in-service units. Operational criteria for the major electronic functions are detailed, as are adjustments and calibration procedures, and recurrent mechanical/electromechanical problems are addressed. Some system tests are included for quality assurance. Data on nonstandard large-scale integrated (circuit) components and a schematic set are also included.

  17. Ulcerative colitis six years after colon cancer: only a coincidence?

    Science.gov (United States)

    Sakellakis, Minas; Makatsoris, Thomas; Gkermpesi, Maria; Peroukidis, Stavros; Kalofonos, Haralabos

    2014-01-01

    The association between inflammatory bowel disease and colorectal cancer is well known. Ulcerative colitis is a risk factor for the development of colorectal cancer, and this risk increases with the activity and duration of bowel inflammation. Here we describe the case of a 52-year-old man who developed ulcerative colitis 6 years after the diagnosis and treatment of colon cancer. Although this could be a coincidence, there could be additional possibilities, like pre-existence of quiescent colitis, late effect of therapy, or maybe the existence of common pathogenetic factors contributing to the development of ulcerative colitis and colorectal cancer. PMID:24855393

  18. Radiative Corrections to Polarized Inelastic Scattering in Coincidence

    Energy Technology Data Exchange (ETDEWEB)

    Igor Akushevich; Andrei Afanasev; G.I. Gakh; Mykola Merenkov

    2001-09-01

    The complete analysis of the model-independent leading radiative corrections to cross-section and polarization observables in semi-inclusive deep-inelastic electron-nucleus scattering with detection of a proton and scattered electron in coincidence has been performed. The basis of the calculations consists of the Drell-Yan like representation in electrodynamics for both spin-independent and spin-dependent parts of the cross-section in terms of the electron structure functions. The applications to the polarization transfer effect from longitudinally polarized electron beam to detected proton as well as to scattering by the polarized target are considered.

  19. Coincidence corrected efficiency calibration of Compton-suppressed HPGe detectors

    Energy Technology Data Exchange (ETDEWEB)

    Aucott, Timothy [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Brand, Alexander [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); DiPrete, David [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-04-20

    The authors present a reliable method to calibrate the full-energy efficiency and the coincidence correction factors using a commonly-available mixed source gamma standard. This is accomplished by measuring the peak areas from both summing and non-summing decay schemes and simultaneously fitting both the full-energy efficiency, as well as the total efficiency, as functions of energy. By using known decay schemes, these functions can then be used to provide correction factors for other nuclides not included in the calibration standard.

  20. Absolute cross-sections from X-{gamma} coincidence measurements

    Energy Technology Data Exchange (ETDEWEB)

    Lemasson, A. [GANIL, CEA/DSM - CNRS/IN2P3, Bd Henri Becquerel, BP 55027, F-14076 Caen Cedex 5 (France); Shrivastava, A. [Nuclear Physics Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Navin, A. [GANIL, CEA/DSM - CNRS/IN2P3, Bd Henri Becquerel, BP 55027, F-14076 Caen Cedex 5 (France)], E-mail: navin@ganil.fr; Rejmund, M. [GANIL, CEA/DSM - CNRS/IN2P3, Bd Henri Becquerel, BP 55027, F-14076 Caen Cedex 5 (France); Nanal, V. [Department of Nuclear and Atomic Physics, Tata Institute of Fundamental Research, Mumbai 400005 (India); Bhattacharyya, S. [Variable Energy Cyclotron Centre, 1/AF Bidhan Nagar, Kolkata 700064 (India); Chatterjee, A.; Kailas, S.; Mahata, K.; Parkar, V.V. [Nuclear Physics Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Pillay, R.G. [Department of Nuclear and Atomic Physics, Tata Institute of Fundamental Research, Mumbai 400005 (India); Ramachandran, K.; Rout, P.C. [Nuclear Physics Division, Bhabha Atomic Research Centre, Mumbai 400085 (India)

    2009-01-11

    An activation technique using coincidences between characteristic X-rays and {gamma}-rays to obtain absolute cross-sections is described. This method is particularly useful in the case of nuclei that decay by electron capture. In addition to the reduction of possible contamination, an improved detection sensitivity is achieved as compared to inclusive measurements, thereby allowing the extraction of absolute fusion cross-sections in the nano-barn range. Results of this technique for {sup 6}Li+{sup 198}Pt system, at energies around the Coulomb barrier are described. Future applications with low intensity radioactive ion beams are also discussed.

  1. Coincident systemic lupus erythematosus and psoriasis vulgaris: a case report.

    Science.gov (United States)

    Wang, Y; Da, G; Yu, Y; Han, J; Li, H

    2015-12-01

    Psoriasis vulgaris is an autoimmune chronic inflammatory skin disease, but its association with other typical autoimmune disease such as systemic lupus erythematosus has only occasionally been reported. We presented a 25-year-old female who developed systemic lupus erythematosus associated with psoriasis vulgaris. Her conditions were in good control after she got administration of prednisolone (5 mg/day) and Tripterygium Wilfordii Hook (20 mg/day). It is necessary to integrate past history and physical examination to diagnose coincident SLE and psoriasis, and combined treatment with prednisolone and Tripterygium Wilfordii Hook proves effective.

  2. Spectroscopy of fission fragments using prompt-delayed coincidence technique

    Indian Academy of Sciences (India)

    R Palit; S Biswas

    2015-09-01

    The time-stamp structure of the digital data acquisition system of the Indian National Gamma Array (INGA) has been utilized to carry out prompt-delayed coincidence technique for the spectroscopic study of fission fragments. This technique was found to be useful to determine the states above the long-lived isomer (with half-life up to ∼5 s), present in the fission fragments. The angular correlation of -rays, emitted by the fission fragments, has also been used in the present INGA geometry to determine the spins of the de-exciting states.

  3. Joint spectrum of photon pairs measured by coincidence Fourier spectroscopy

    CERN Document Server

    Wasilewski, W; Kolenderski, P; Banaszek, K; Radzewicz, C; Wasilewski, Wojciech; Wasylczyk, Piotr; Kolenderski, Piotr; Banaszek, Konrad; Radzewicz, Czeslaw

    2005-01-01

    We propose and demonstrate a method for measuring the joint spectrum of photon pairs via Fourier spectroscopy. The biphoton spectral intensity is computed from a two-dimensional interferogram of coincidence counts. The method has been implemented for a type-I downconversion source using a pair of common-path Mach-Zender interferometers based on Soleil compensators. The experimental results agree well with calculated frequency correlations that take into account the effects of coupling into single-mode fibers. The Fourier method is advantageous over scanning spectrometry when detectors exhibit high dark count rates leading to dominant additive noise.

  4. Radio transient following FRB 150418: afterglow or coincident AGN flare?

    CERN Document Server

    Li, Ye

    2016-01-01

    Recently, Keane et al. reported the discovery of a fading radio transient following FRB 150418, and interpreted it as the afterglow of the FRB. Williams \\& Berger, on the other hand, suggested that the radio transient is analogous to a group of variable radio sources, so that it could be a coincident AGN flare in the observational beam of the FRB. A new observation with VLA showed a re-brightening, which is consistent with the AGN picture. Here, using the radio survey data of Ofek et al., we statistically examine the chance coincidence probability to produce an event like the FRB 150418 transient. We find that the probabilities to produce a variable radio transient with at least the same variability amplitude and signal-to-noise ratio as the FRB 150415 transient, without and with the VLA point, are $P_1 \\sim 6 \\times 10^{-4}$ and $P_1 \\sim 2 \\times 10^{-3}$, respectively. In addition, the chance probability to have a fading transient detected following a random time (FRB time) is less than $P_2 \\sim 10^{-...

  5. Photoelectron-Auger electron coincidence study for condensed matter

    Energy Technology Data Exchange (ETDEWEB)

    Stefani, G. [Department of Physics and Unita' INFM, University Roma Tre, Via della Vasca Navale 84, I-00146 Rome (Italy)]. E-mail: stefani@fis.uniroma3.it; Gotter, R. [National Laboratory TASC-INFM, Area Science Park, SS 14 Km 163.5, Basovizza, I-34012 Trieste (Italy); Ruocco, A. [Department of Physics and Unita INFM, University Roma Tre, Via della Vasca Navale 84, I-00146 Rome (Italy); Offi, F. [Department of Physics and Unita INFM, University Roma Tre, Via della Vasca Navale 84, I-00146 Rome (Italy); Pieve, F. Da [Department of Physics and Unita INFM, University Roma Tre, Via della Vasca Navale 84, I-00146 Rome (Italy); Iacobucci, S. [IMIP-CNR Area della Ricerca di Roma, via Salaria Km 29, 3 Montelibretti (Italy); Morgante, A. [National Laboratory TASC-INFM, Area Science Park, SS 14 Km 163.5, Basovizza, I-34012 Trieste (Italy); Verdini, A. [National Laboratory TASC-INFM, Area Science Park, SS 14 Km 163.5, Basovizza, I-34012 Trieste (Italy); Liscio, A. [IMIP-CNR Area della Ricerca di Roma, via Salaria Km 29, 3 Montelibretti (Italy); Yao, H. [Department of Physics and Astronomy and Laboratory of Surface Modification, Rutgers University, 136 Frelinghuysen Road, Piscataway, NJ 08855 (United States); Bartynski, R.A. [Department of Physics and Astronomy and Laboratory of Surface Modification, Rutgers University, 136 Frelinghuysen Road, Piscataway, NJ 08855 (United States)

    2004-12-01

    Advances in materials science have produced a wide array of new solid-state systems with tunable properties and previously unattainable combinations of phenomena that hold the promise of entirely new approaches to technological applications. Invariably, these new materials are increasingly complex and include a large number of constituents in a variety of chemical states. Entirely new theoretical and experimental approaches are needed to gain the insights necessary for intelligent engineering of these materials. In the past 20 years, a steadily increasing number of electron-electron coincidence experiments on atoms and molecules have demonstrated the capability of investigating complicated systems with sensitivity and specificity well beyond the limits imposed by conventional electron spectroscopies. Over the past decade or so, Auger-photoelectron coincidence spectroscopy (APECS) has emerged as a powerful technique for obtaining detailed information about complex materials systems. Moreover, the recent advent of angle-resolved (AR)-APECS has introduced a new level of discrimination in studying the distribution of electrons photoemitted from complex systems. In this review, we describe the basic ideas behind APECS and discuss a study of the SiO{sub 2} system as an example of the unique information this technique can provide. We then introduce the concept of AR-APECS, explain its novel state and angular momentum selectivity that can be used to disentangle information about complex systems that is hidden to conventional spectroscopies. Examples of AR-APECS measurements from Cu, Ge, and graphite that exemplify the capabilities of this technique are presented.

  6. CSF biomarkers cutoffs: the importance of coincident neuropathological diseases.

    Science.gov (United States)

    Toledo, Jon B; Brettschneider, Johannes; Grossman, Murray; Arnold, Steven E; Hu, William T; Xie, Sharon X; Lee, Virginia M-Y; Shaw, Leslie M; Trojanowski, John Q

    2012-07-01

    The effects of applying clinical versus neuropathological diagnosis and the inclusion of cases with coincident neuropathological diagnoses have not been assessed specifically when studying cerebrospinal fluid (CSF) biomarker classification cutoffs for patients with neurodegenerative diseases that cause dementia. Thus, 142 neuropathologically diagnosed neurodegenerative dementia patients [71 Alzheimer's disease (AD), 29 frontotemporal lobar degeneration (FTLD), 3 amyotrophic lateral sclerosis, 7 dementia with Lewy bodies, 32 of which cases also had coincident diagnoses] were studied. 96 % had enzyme-linked immunosorbant assay (ELISA) CSF data and 77 % had Luminex CSF data, with 43 and 46 controls for comparison, respectively. Aβ(42), total, and phosphorylated tau(181) were measured. Clinical and neuropathological diagnoses showed an 81.4 % overall agreement. Both assays showed high sensitivity and specificity to classify AD subjects against FTLD subjects and controls, and moderate sensitivity and specificity for classifying FTLD subjects against controls. However, among the cases with neuropathological diagnoses of AD plus another pathology (26.8 % of the sample), 69.4 % (ELISA) and 96.4 % (Luminex) were classified as AD according to their biomarker profiles. Use of clinical diagnosis instead of neuropathological diagnosis led to a 14-17 % underestimation of the biomarker accuracy. These results show that while CSF Aβ and tau assays are useful for diagnosis of AD and neurodegenerative diseases even at MCI stages, CSF diagnostic analyte panels that establish a positive diagnosis of Lewy body disease and FTLD are also needed, and must be established based on neuropathological rather than clinical diagnoses.

  7. First principle active neutron coincidence counting measurements of uranium oxide

    Science.gov (United States)

    Goddard, Braden; Charlton, William; Peerani, Paolo

    2014-03-01

    Uranium is present in most nuclear fuel cycle facilities ranging from uranium mines, enrichment plants, fuel fabrication facilities, nuclear reactors, and reprocessing plants. The isotopic, chemical, and geometric composition of uranium can vary significantly between these facilities, depending on the application and type of facility. Examples of this variation are: enrichments varying from depleted (~0.2 wt% 235U) to high enriched (>20 wt% 235U); compositions consisting of U3O8, UO2, UF6, metallic, and ceramic forms; geometries ranging from plates, cans, and rods; and masses which can range from a 500 kg fuel assembly down to a few grams fuel pellet. Since 235U is a fissile material, it is routinely safeguarded in these facilities. Current techniques for quantifying the 235U mass in a sample include neutron coincidence counting. One of the main disadvantages of this technique is that it requires a known standard of representative geometry and composition for calibration, which opens up a pathway for potential erroneous declarations by the State and reduces the effectiveness of safeguards. In order to address this weakness, the authors have developed a neutron coincidence counting technique which uses the first principle point-model developed by Boehnel instead of the "known standard" method. This technique was primarily tested through simulations of 1000 g U3O8 samples using the Monte Carlo N-Particle eXtended (MCNPX) code. The results of these simulations showed good agreement between the simulated and exact 235U sample masses.

  8. Coincidence-anticipation timing requirements are different in racket sports.

    Science.gov (United States)

    Akpinar, Selçuk; Devrilmez, Erhan; Kirazci, Sadettin

    2012-10-01

    The aim of this study was to compare the coincidence-anticipation timing accuracy of athletes of different racket sports with various stimulus velocity requirements. Ninety players (15 girls, 15 boys for each sport) from tennis (M age = 12.4 yr., SD = 1.4), badminton (M age = 12.5 yr., SD = 1.4), and table tennis (M age = 12.4 yr., SD = 1.2) participated in this study. Three different stimulus velocities, low, moderate, and high, were used to simulate the velocity requirements of these racket sports. Tennis players had higher accuracy when they performed under the low stimulus velocity compared to badminton and table tennis players. Badminton players performed better under the moderate speed comparing to tennis and table tennis players. Table tennis players had better performance than tennis and badminton players under the high stimulus velocity. Therefore, visual and motor systems of players from different racket sports may adapt to a stimulus velocity in coincidence-anticipation timing, which is specific to each type of racket sports.

  9. Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo.

    Science.gov (United States)

    Yu, Dan; Dong, Zhiqiang; Gustafson, William Clay; Ruiz-González, Rubén; Signor, Luca; Marzocca, Fanny; Borel, Franck; Klassen, Matthew P; Makhijani, Kalpana; Royant, Antoine; Jan, Yuh-Nung; Weiss, William A; Guo, Su; Shu, Xiaokun

    2016-02-01

    Fluorescent proteins (FPs) are powerful tools for cell and molecular biology. Here based on structural analysis, a blue-shifted mutant of a recently engineered monomeric infrared fluorescent protein (mIFP) has been rationally designed. This variant, named iBlueberry, bears a single mutation that shifts both excitation and emission spectra by approximately 40 nm. Furthermore, iBlueberry is four times more photostable than mIFP, rendering it more advantageous for imaging protein dynamics. By tagging iBlueberry to centrin, it has been demonstrated that the fusion protein labels the centrosome in the developing zebrafish embryo. Together with GFP-labeled nucleus and tdTomato-labeled plasma membrane, time-lapse imaging to visualize the dynamics of centrosomes in radial glia neural progenitors in the intact zebrafish brain has been demonstrated. It is further shown that iBlueberry can be used together with mIFP in two-color protein labeling in living cells and in two-color tumor labeling in mice.

  10. A neutron detector for (p,np) coincidence studies

    CERN Document Server

    Carman, D S; Chant, N S; Eads, A; Gu, T; Huber, G M; Huffman, J; Klyachko, A; Markham, B C; Roos, P G; Schwandt, P; Solberg, K

    1999-01-01

    A neutron detector with moderate energy resolution (approx 3 MeV) has been built for neutrons in the energy range 75-175 MeV. The detector was designed for coincidence scattering experiments. The design eliminates the need for long neutron flight paths necessary for comparable energy resolution time-of-flight measurements with a comparable efficiency-solid angle product (0.02 msr). The detector consists of thin plastic scintillators in which the neutron undergoes n-p elastic scattering. The second-scattered protons are tracked by drift chambers and detected in a sodium iodide array. The design motivations and features are presented along with results from detailed in-beam experimental tests.

  11. Sub-wavelength bubble in photon coincidence detection

    CERN Document Server

    Liu, Ruifeng; Zhou, Yu; Gao, Hong; Li, Fuli

    2013-01-01

    Sub-wavelength interference has a potential application in lithography to beat the classical Rayleigh limit of resolution. We carefully study the second-order correlation theory and find there is a bubble of sub-wavelength interference in photon coincidence detection. A Young's double-slit experiment with thermal light is carried out to test the second-order correlation pattern. The result shows that when different scanning ways of two point detectors are chosen, we can get arbitrary-wavelength interference patterns. We then give a theoretical explanation to this surprising result, and find this explanation is also suitable for the result by using entangled light. Furthermore, the question of whether this kind of arbitrary-wavelength interference patterns can be used in quantum lithography is also analyzed.

  12. Ulcerative colitis six years after colon cancer: only a coincidence?

    Directory of Open Access Journals (Sweden)

    Sakellakis M

    2014-04-01

    Full Text Available Minas Sakellakis,1 Thomas Makatsoris,1 Maria Gkermpesi,2 Stavros Peroukidis,1 Haralabos Kalofonos11Division of Oncology, Department of Medicine, 2Department of Pathology, University, Hospital of Patras, Patras, GreeceAbstract: The association between inflammatory bowel disease and colorectal cancer is well known. Ulcerative colitis is a risk factor for the development of colorectal cancer, and this risk increases with the activity and duration of bowel inflammation. Here we describe the case of a 52-year-old man who developed ulcerative colitis 6 years after the diagnosis and treatment of colon cancer. Although this could be a coincidence, there could be additional possibilities, like pre-existence of quiescent colitis, late effect of therapy, or maybe the existence of common pathogenetic factors contributing to the development of ulcerative colitis and colorectal cancer.Keywords: ulcerative, colitis, colorectal, cancer, inflammation

  13. Cardiac Rhabdomyomas and Congenital Hypothyroidism: A Coincidence or Hamartia

    Directory of Open Access Journals (Sweden)

    Anand Agarwal

    2015-11-01

    Full Text Available Cardiac rhabdomyomas are the most common primary cardiac tumors in children. These tumors are generally asymptomatic, although they may be associated with neonatal tuberous sclerosis complex. Despite the fact that thyroid dysfunction rarely occurs in tuberous sclerosis, papillary adenomas (hamartomas of the thyroid gland have been reported in a number of autopsies. Herein, we present the case of an infant with tuberous sclerosis, congenital hypothyroidism and multiple cardiac rhabdomyomas, leading to atrioventricular node dysfunction. Considering the rarity of this co-occurrence, we decided to report the present case. The co-occurrence of these two disorders in one patient may be a mere coincidence or related to hamartoma of the thyroid gland as a consequence of tuberous sclerosis gene products.

  14. Serendipity in Cancer Drug Discovery: Rational or Coincidence?

    Science.gov (United States)

    Prasad, Sahdeo; Gupta, Subash C; Aggarwal, Bharat B

    2016-06-01

    Novel drug development leading to final approval by the US FDA can cost as much as two billion dollars. Why the cost of novel drug discovery is so expensive is unclear, but high failure rates at the preclinical and clinical stages are major reasons. Although therapies targeting a given cell signaling pathway or a protein have become prominent in drug discovery, such treatments have done little in preventing or treating any disease alone because most chronic diseases have been found to be multigenic. A review of the discovery of numerous drugs currently being used for various diseases including cancer, diabetes, cardiovascular, pulmonary, and autoimmune diseases indicates that serendipity has played a major role in the discovery. In this review we provide evidence that rational drug discovery and targeted therapies have minimal roles in drug discovery, and that serendipity and coincidence have played and continue to play major roles. The primary focus in this review is on cancer-related drug discovery.

  15. Commentary on Bayesian coincidence assessment (cross-matching)

    CERN Document Server

    Loredo, Thomas J

    2012-01-01

    This paper is an invited commentary on Tamas Budavari's presentation, "On statistical cross-identification in astronomy," for the Statistical Challenges in Modern Astronomy V conference held at Pennsylvania State University in June 2011. I begin with a brief review of previous work on probabilistic (Bayesian) assessment of directional and spatio-temporal coincidences in astronomy (e.g., cross-matching or cross-identification of objects across multiple catalogs). Then I discuss an open issue in the recent innovative work of Budavari and his colleagues on large-scale probabilistic cross-identification: how to assign prior probabilities that play an important role in the analysis. With a simple toy problem, I show how Bayesian multilevel modeling (hierarchical Bayes) provides a principled framework that justifies and generalizes pragmatic rules of thumb that have been successfully used by Budavari's team to assign priors.

  16. Gamma Efficiency Simulations towards Coincidence Measurements for Fusion Cross Sections

    Science.gov (United States)

    Heine, M.; Courtin, S.; Fruet, G.; Jenkins, D. G.; Montanari, D.; Morris, L.; Regan, P. H.; Rudigier, M.; Symochko, D.

    2016-10-01

    With the experimental station STELLA (STELlar LAboratory) we will measure fusion cross sections of astrophysical relevance making use of the coincident detection of charged particles and gamma rays for background reduction. For the measurement of gamma rays from the de-excitation of fusion products a compact array of 36 UK FATIMA LaBr3 detectors is designed based on efficiency studies with Geant4. The photo peak efficiency in the region of interest compares to other gamma detection systems used in this field. The features of the internal decay of 138La is used in a background study to obtain an online calibration of the gamma detectors. Background data are fit to the Monte Carlo model of the self activity assuming crude exponential behavior of external background. Accuracy in the region of interest is of the order of some keV in this first study.

  17. Coincident photoelectron spectroscopy on superconductors; Koinzidente Photoelektronenspektroskopie an Supraleitern

    Energy Technology Data Exchange (ETDEWEB)

    Voss, Stefan

    2011-07-01

    Aim of the performed experiments of this thesis was to attempt to detect Cooper pairs as carriers of the superconducting current directly by means of the photoelectric effect. The method of the coincident photoelectron spectroscopy aims thereby at the detection of two coherently emitted electrons by the interaction with a photon. Because electrostatic analyzers typically cover only a very small spatial angle, which goes along with very low coincidence rates, in connection with this thesis a time-of-flight projection system has been developed, which maps nearly the whole spatial angle on a position-resolving detector. The pulsed light source in form of special synchrotron radiation necessary for the measurement has been adjusted so weak, that only single photons could arrive at the sample. Spectroscoped were beside test measurements on silver layers both a lead monocrystal as representative of the classical BCS superconductors and monocrystalline Bi{sub 2}Sr{sub 2}CaCu{sub 2}O{sub 8} from the family of the high-temperature superconductors. With excitation energies up to 40 eV could be shown that sufficiently smooth and clean surfaces in the superconducting phase exhibit within the resolving power of about 0.5 eV no recognizable differences in comparison to the normally conducting phase. Beside these studies furthermore the simple photoemission at the different samples and especially in the case of the lead crystal is treated, because here no comparable results are known. Thereby the whole momentum space is discussed and the Fermi surface established as three-dimensional model, by means of which the measurement results are discussed. in the theoretical descriptions different models for the Cooper-pair production are presented, whereby to the momentum exchange with the crystal a special role is attributed, because this can only occur in direct excitations via discrete lattice vectors.

  18. Theoretical Bounds and Practical Constructions for Families of One—Coincidence Sequences in FHMA

    Institute of Scientific and Technical Information of China (English)

    MeiWenhua; YangYixian

    1995-01-01

    Theoretical bounds are given for the number of one-coincidence sequences in syn-chronous FHMA systems,and for the number and period of one-coincidence sequences in asyn-chronous FHMA systems.Several practical constructions for families of one-coincidencesequences are surveyed,and a new model for families of one-coincidence sequences is presented.

  19. Evaluation of reference-based two-color methods for measurement of gene expression ratios using spotted cDNA microarrays

    Directory of Open Access Journals (Sweden)

    Verjovski-Almeida Sergio

    2006-02-01

    Full Text Available Abstract Background Spotted cDNA microarrays generally employ co-hybridization of fluorescently-labeled RNA targets to produce gene expression ratios for subsequent analysis. Direct comparison of two RNA samples in the same microarray provides the highest level of accuracy; however, due to the number of combinatorial pair-wise comparisons, the direct method is impractical for studies including large number of individual samples (e.g., tumor classification studies. For such studies, indirect comparisons using a common reference standard have been the preferred method. Here we evaluated the precision and accuracy of reconstructed ratios from three indirect methods relative to ratios obtained from direct hybridizations, herein considered as the gold-standard. Results We performed hybridizations using a fixed amount of Cy3-labeled reference oligonucleotide (RefOligo against distinct Cy5-labeled targets from prostate, breast and kidney tumor samples. Reconstructed ratios between all tissue pairs were derived from ratios between each tissue sample and RefOligo. Reconstructed ratios were compared to (i ratios obtained in parallel from direct pair-wise hybridizations of tissue samples, and to (ii reconstructed ratios derived from hybridization of each tissue against a reference RNA pool (RefPool. To evaluate the effect of the external references, reconstructed ratios were also calculated directly from intensity values of single-channel (One-Color measurements derived from tissue sample data collected in the RefOligo experiments. We show that the average coefficient of variation of ratios between intra- and inter-slide replicates derived from RefOligo, RefPool and One-Color were similar and 2 to 4-fold higher than ratios obtained in direct hybridizations. Correlation coefficients calculated for all three tissue comparisons were also similar. In addition, the performance of all indirect methods in terms of their robustness to identify genes deemed as

  20. Methodology for assessing probability of extreme hydrologic events coincidence

    Directory of Open Access Journals (Sweden)

    Prohaska Stevan

    2010-01-01

    Full Text Available The aim of the presented research is improvement of methodology for probability calculation of coinciding occurrence of historic floods and droughts in the same year. The original procedure was developed in order to determine the occurrence probability of such an extreme historic event. There are two phases in calculation procedure for assessment of both extreme drought and flood occurrence probability in the same year. In the first phase outliers are detected as indicators of extreme events, their return periods are calculated and series' statistics adjusted. In the second phase conditional probabilities are calculated: empirical points are plotted, and both extreme drought and flood occurrence probability in the same year is assessed based on the plot. Outlier detection is performed for the territory of Serbia. Results are shown as maps of regions (basins prone to floods, hydrologic drought, or both. Step-by-step numeric example is given for assessing conditional probability of occurrence of flood and drought for GS Raska on the river Raska. Results of assessment of conditional probability in two more cases are given for combination of extreme flood and 30 day minimum flow.

  1. Dubin-Johnson syndrome coinciding with colon cancer and atherosclerosis.

    Science.gov (United States)

    Sticova, Eva; Elleder, Milan; Hulkova, Helena; Luksan, Ondrej; Sauer, Martin; Wunschova-Moudra, Irena; Novotny, Jan; Jirsa, Milan

    2013-02-14

    Hyperbilirubinemia has been presumed to prevent the process of atherogenesis and cancerogenesis mainly by decreasing oxidative stress. Dubin-Johnson syndrome is a rare, autosomal recessive, inherited disorder characterized by biphasic, predominantly conjugated hyperbilirubinemia with no progression to end-stage liver disease. The molecular basis in Dubin-Johnson syndrome is absence or deficiency of human canalicular multispecific organic anion transporter MRP2/cMOAT caused by homozygous or compound heterozygous mutation(s) in ABCC2 located on chromosome 10q24. Clinical onset of the syndrome is most often seen in the late teens or early adulthood. In this report, we describe a case of previously unrecognized Dubin-Johnson syndrome caused by two novel pathogenic mutations (c.2360_2366delCCCTGTC and c.3258+1G>A), coinciding with cholestatic liver disease in an 82-year-old male patient. The patient, suffering from advanced atherosclerosis with serious involvement of coronary arteries, developed colorectal cancer with nodal metastases. The subsequent findings do not support the protective role of Dubin-Johnson type hyperbilirubinemia.

  2. Super sub-wavelength patterns in photon coincidence detection

    Science.gov (United States)

    Liu, Ruifeng; Zhang, Pei; Zhou, Yu; Gao, Hong; Li, Fuli

    2014-02-01

    High-precision measurements implemented with light are desired in all fields of science. However, light acts as a wave, and the Rayleigh criterion in classical optics yields a diffraction limit that prevents obtaining a resolution smaller than the wavelength. Sub-wavelength interference has potential application in lithography because it beats the classical Rayleigh resolution limit. Here, we carefully study second-order correlation theory to establish the physics behind sub-wavelength interference in photon coincidence detection. A Young's double slit experiment with pseudo-thermal light is performed to test the second-order correlation pattern. The results show that when two point detectors are scanned in different ways, super sub-wavelength interference patterns can be obtained. We then provide a theoretical explanation for this surprising result, and demonstrate that this explanation is also suitable for the results found for entangled light. Furthermore, we discuss the limitations of these types of super sub-wavelength interference patterns in quantum lithography.

  3. Coincidence ion imaging with a fast frame camera

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Suk Kyoung; Cudry, Fadia; Lin, Yun Fei; Lingenfelter, Steven; Winney, Alexander H.; Fan, Lin; Li, Wen, E-mail: wli@chem.wayne.edu [Department of Chemistry, Wayne State University, Detroit, Michigan 48202 (United States)

    2014-12-15

    A new time- and position-sensitive particle detection system based on a fast frame CMOS (complementary metal-oxide semiconductors) camera is developed for coincidence ion imaging. The system is composed of four major components: a conventional microchannel plate/phosphor screen ion imager, a fast frame CMOS camera, a single anode photomultiplier tube (PMT), and a high-speed digitizer. The system collects the positional information of ions from a fast frame camera through real-time centroiding while the arrival times are obtained from the timing signal of a PMT processed by a high-speed digitizer. Multi-hit capability is achieved by correlating the intensity of ion spots on each camera frame with the peak heights on the corresponding time-of-flight spectrum of a PMT. Efficient computer algorithms are developed to process camera frames and digitizer traces in real-time at 1 kHz laser repetition rate. We demonstrate the capability of this system by detecting a momentum-matched co-fragments pair (methyl and iodine cations) produced from strong field dissociative double ionization of methyl iodide.

  4. Analytical model of coincidence resolving time in TOF-PET.

    Science.gov (United States)

    Wieczorek, H; Thon, A; Dey, T; Khanin, V; Rodnyi, P

    2016-06-21

    The coincidence resolving time (CRT) of scintillation detectors is the parameter determining noise reduction in time-of-flight PET. We derive an analytical CRT model based on the statistical distribution of photons for two different prototype scintillators. For the first one, characterized by single exponential decay, CRT is proportional to the decay time and inversely proportional to the number of photons, with a square root dependence on the trigger level. For the second scintillator prototype, characterized by exponential rise and decay, CRT is proportional to the square root of the product of rise time and decay time divided by the doubled number of photons, and it is nearly independent of the trigger level. This theory is verified by measurements of scintillation time constants, light yield and CRT on scintillator sticks. Trapping effects are taken into account by defining an effective decay time. We show that in terms of signal-to-noise ratio, CRT is as important as patient dose, imaging time or PET system sensitivity. The noise reduction effect of better timing resolution is verified and visualized by Monte Carlo simulation of a NEMA image quality phantom.

  5. Strings, boundary fermions and coincident D-branes

    CERN Document Server

    Wulff, L

    2007-01-01

    This thesis describes an attempt to write down covariant actions for coincident D-branes using so-called boundary fermions instead of matrices to describe the non-abelian fields. These fermions can be thought of as Chan-Paton degrees of freedom for the open string. It is shown that by gauge-fixing and by suitably quantizing these boundary fermions the non-abelian action that is known, the Myers action, can be reproduced. Furthermore it is shown that under natural assumptions, unlike the Myers action, the action formulated using boundary fermions also posseses kappa-symmetry when formulated on superspace. Another aspect of string theory discussed in this thesis is that of tensionless strings. These are of great interest for example because of their possible relation to higher spin gauge theories via the AdS/CFT-correspondence. The tensionless superstring in a plane wave background, a Penrose limit of the near-horizon geometry of a stack of D3-branes, is considered and compared to the tensile case.

  6. The Structure of the Cubic Coincident Site Lattice Rotation Group

    Energy Technology Data Exchange (ETDEWEB)

    Reed, B W; Minich, R W; Rudd, R E; Kumar, M

    2004-01-13

    This work is intended to be a mathematical underpinning for the field of grain boundary engineering and its relatives. The interrelationships within the set of rotations producing coincident site lattices in cubic crystals are examined in detail. Besides combining previously established but widely scattered results into a unified context, the present work details newly developed representations of the group structure in terms of strings of generators (based on quaternionic number theory, and including uniqueness proofs and rules for algebraic manipulation) as well as an easily visualized topological network model. Important results that were previously obscure or not universally understood (e.g. the {Sigma} combination rule governing triple junctions) are clarified in these frameworks. The methods also facilitate several general observations, including the very different natures of twin-limited structures in two and three dimensions, the inadequacy of the {Sigma} combination rule to determine valid quadruple nodes, and a curious link between allowable grain boundary assignments and the four-color map theorem. This kind of understanding is essential to the generation of realistic statistical models of grain boundary networks (particularly in twin-dominated systems) and is especially applicable to the field of grain boundary engineering.

  7. Coincident Phosphatidic Acid Interaction Restrains Drp1 in Mitochondrial Division.

    Science.gov (United States)

    Adachi, Yoshihiro; Itoh, Kie; Yamada, Tatsuya; Cerveny, Kara L; Suzuki, Takamichi L; Macdonald, Patrick; Frohman, Michael A; Ramachandran, Rajesh; Iijima, Miho; Sesaki, Hiromi

    2016-09-15

    Mitochondria divide to control their size, distribution, turnover, and function. Dynamin-related protein 1 (Drp1) is a critical mechanochemical GTPase that drives constriction during mitochondrial division. It is generally believed that mitochondrial division is regulated during recruitment of Drp1 to mitochondria and its oligomerization into a division apparatus. Here, we report an unforeseen mechanism that regulates mitochondrial division by coincident interactions of Drp1 with the head group and acyl chains of phospholipids. Drp1 recognizes the head group of phosphatidic acid (PA) and two saturated acyl chains of another phospholipid by penetrating into the hydrophobic core of the membrane. The dual phospholipid interactions restrain Drp1 via inhibition of oligomerization-stimulated GTP hydrolysis that promotes membrane constriction. Moreover, a PA-producing phospholipase, MitoPLD, binds Drp1, creating a PA-rich microenvironment in the vicinity of a division apparatus. Thus, PA controls the activation of Drp1 after the formation of the division apparatus.

  8. Coincidence of Trisomy 18 and Robertsonian (13; 14

    Directory of Open Access Journals (Sweden)

    A Alavi

    2012-07-01

    Full Text Available This case report presents a coincidence of trisomy 18 and balanced Robertsonian translocation (13;14. Aneuploidy was suspected based on anomalies detected in ultrasound scan and confirmed with karyotype. In a 31 years-old healthy woman with a history of one miscarriage, second trimester ultrasound scan reported IUGR (<3rd percentile with normal amniotic fluid, bilateral choroid plexus cysts, suspicious agenesis of corpus callosum and clenched hands. Amniocentesis was performed and karyotype was 46xx,der(13;14 (q10;q10,+18. Maternal karyotype was 45xx,der(13;14(q10;q10. Pregnancy was continued due to legal limitation for termination after 20 weeks gestation. Delivery was done at 36 weeks gestation. A female newborn was borned and a physical feature was hypotonia, small mouth, prominent occiput, low-set and posteriorly rotated ears, clenched hands with overlapping fingers and rocker bottom feet. Ultrasound scan and echocardiography detected agenesis of corpus callosum and VSD, ASD, PDA and cardiomegaly. These features are typical of trisomy 18. Balanced Robertsonian translocation usually has no phenotypic expression. Genetic counseling and prenatal diagnosis for future pregnancy was recommended.

  9. The optimum choice of gate width for neutron coincidence counting

    Science.gov (United States)

    Croft, S.; Henzlova, D.; Favalli, A.; Hauck, D. K.; Santi, P. A.

    2014-11-01

    In the measurement field of international nuclear safeguards, passive neutron coincidence counting is used to quantify the spontaneous fission rate of certain special nuclear materials. The shift register autocorrelation analysis method is the most commonly used approach. However, the Feynman-Y technique, which is more commonly applied in reactor noise analysis, provides an alternative means to extract the correlation information from a pulse train. In this work we consider how to select the optimum gate width for each of these two time-correlation analysis techniques. The optimum is considered to be that which gives the lowest fractional precision on the net doublets rate. Our theoretical approach is approximate but is instructional in terms of revealing the key functional dependence. We show that in both cases the same performance figure of merit applies so that common design criteria apply to the neutron detector head. Our prediction is that near optimal results, suitable for most practical applications, can be obtained from both techniques using a common gate width setting. The estimated precision is also comparable in the two cases. The theoretical expressions are tested experimentally using 252Cf spontaneous fission sources measured in two thermal well counters representative of the type in common use by international inspectorates. Fast accidental sampling was the favored method of acquiring the Feynman-Y data. Our experimental study confirmed the basic functional dependences predicted although experimental results when available are preferred. With an appropriate gate setting Feynman-Y analysis provides an alternative to shift register analysis for safeguards applications which is opening up new avenues of data collection and data reduction to explore.

  10. Coincident Observations of Surface Ozone and NMVOCs over Abu Dhabi

    Science.gov (United States)

    Abbasi, Naveed; Majeed, Tariq; Iqbal, Mazhar; Tarasick, David; Davies, Jonathan; Riemer, Daniel; Apel, Eric

    2016-07-01

    The vertical profiles of ozone are measured coincidently with non-methane volatile organic compounds (NMVOCs) at the meteorological site located at the Abu Dhabi international airport (latitude 24.45N; longitude 54.22E) during the years 2012 - 2014. Some of the profiles show elevated surface ozone >95 ppbv during the winter months (December, January and February). The ground-level NMVOCs obtained from the gas chromatography-flame ionization detection/mass spectrometry system also show elevated values of acetylene, ethane, propane, butane, pentane, benzene, and toluene. NMVOCs and ozone abundances in other seasons are much lower than the values in winter season. NMVOCs are emitted from an extensive number of sources in urban environments including fuel production, distribution, and consumption, and serve as precursor of ozone. Transport sources contribute a substantial portion of the NMVOC burden to the urban atmosphere in developed regions. Abu Dhabi is located at the edge of the Arabian Gulf and is highly affected by emissions from petrochemical industries in the neighboring Gulf region. The preliminary results indicate that wintertime enhancement in ozone is associated with large values of NMVOCs at Abu Dhabi. The domestic production of surface ozone is estimated from the combination of oxygen recombination and NMVOCs and compared with the data. It is estimated that about 40-50% of ozone in Abu Dhabi is transported from the neighbouring petrochemical industries. We will present ozone sounding and NMVOCs data and our model estimates of surface ozone, including a discussion on the high levels of the tropospheric ozone responsible for contaminating the air quality in the UAE. This work is supported by National Research Foundation, UAE.

  11. The optimum choice of gate width for neutron coincidence counting

    Energy Technology Data Exchange (ETDEWEB)

    Croft, S., E-mail: crofts@ornl.gov [Safeguards and Security Technology (SST), Global Nuclear Security Technology Divisions, PO Box 2008, Building 5700, MS-6166, Oak Ridge, TN 37831-6166 (United States); Henzlova, D.; Favalli, A.; Hauck, D.K.; Santi, P.A. [Safeguards Science and Technology Group (NEN-1), Nuclear Engineering and Nonproliferation Division, MS-E540, Los Alamos, NM 87545 (United States)

    2014-11-11

    In the measurement field of international nuclear safeguards, passive neutron coincidence counting is used to quantify the spontaneous fission rate of certain special nuclear materials. The shift register autocorrelation analysis method is the most commonly used approach. However, the Feynman-Y technique, which is more commonly applied in reactor noise analysis, provides an alternative means to extract the correlation information from a pulse train. In this work we consider how to select the optimum gate width for each of these two time-correlation analysis techniques. The optimum is considered to be that which gives the lowest fractional precision on the net doublets rate. Our theoretical approach is approximate but is instructional in terms of revealing the key functional dependence. We show that in both cases the same performance figure of merit applies so that common design criteria apply to the neutron detector head. Our prediction is that near optimal results, suitable for most practical applications, can be obtained from both techniques using a common gate width setting. The estimated precision is also comparable in the two cases. The theoretical expressions are tested experimentally using {sup 252}Cf spontaneous fission sources measured in two thermal well counters representative of the type in common use by international inspectorates. Fast accidental sampling was the favored method of acquiring the Feynman-Y data. Our experimental study confirmed the basic functional dependences predicted although experimental results when available are preferred. With an appropriate gate setting Feynman-Y analysis provides an alternative to shift register analysis for safeguards applications which is opening up new avenues of data collection and data reduction to explore.

  12. Coincidence symptomatic gall stone and helicobacter pylori: a brief report

    Directory of Open Access Journals (Sweden)

    Seyed Kazem Nezam

    2013-10-01

    Full Text Available Background: On of the most common gasterointrestinal disease is gallstone disease and it`s prevalence is 11%-36%in autopsies. If gallstone leads to symptoms and side effect cholecystectomy will be inevitable. Gastric infection due to H.P will cause several symptoms of which dyspepsia and epigastric pain are outstanding .Gall stones also usually causes epigastric and/or right upper quadrant pain. Pain in other abdominal quadrant is less common. In this study we investigated the coincidence of gall stone and gastro intestinal H.P regarding the common symptom, between these two conditions to prevent unnecessary operation.Methods: The cases were adopted from cholecystectomy candidates due to gall stone disease (proved by ultrasonography. The control group were normal people who proved to be gall stone free ultrasonographicly. Serum IgG anti H.P was checked and compared between the two groups.Results: Seventy percent of patients entered into the study which consisted of 35 case and 35 controls. The two groups were not significantly different in age and gender. There were 22 (68.8% and 10 (31.2% H.P positive cases in case and control groups respectively. Thirteen (34.2% and 25 (65.8% cases were H.P negative in case and control groups respectively. Comparing these results will reveal a statistically significant difference (P=0.004.Conclusion: The relationship between gastric H.P and gall stone in this study supports the role of H.P in gall stone formation. According to our results and the common symptoms of two conditions specially in atypic biliary colic, it seems that in many cases gastrointestinal H.P causes the pain. Prospective studies are recommended.

  13. Fundamentals of fluorescence and fluorescence microscopy.

    Science.gov (United States)

    Wolf, David E

    2013-01-01

    This chapter discusses the fundamental physics of fluorescence. The application of fluorescence to microscopy represents an important transition in the development of microscopy, particularly as it applies to biology. It enables quantitating the amounts of specific molecules within a cell, determining whether molecules are complexing on a molecular level, measuring changes in ionic concentrations within cells and organelles, and measuring molecular dynamics. This chapter also discusses the issues important to quantitative measurement of fluorescence and focuses on four of quantitative measurements of fluorescence--boxcar-gated detection, streak cameras, photon correlation, and phase modulation. Although quantitative measurement presents many pitfalls to the beginner, it also presents significant opportunities to one skilled in the art. This chapter also examines how fluorescence is measured in the steady state and time domain and how fluorescence is applied in the modern epifluorescence microscope.

  14. Murine leukemia virus (MLV replication monitored with fluorescent proteins

    Directory of Open Access Journals (Sweden)

    Bittner Alexandra

    2004-12-01

    Full Text Available Abstract Background Cancer gene therapy will benefit from vectors that are able to replicate in tumor tissue and cause a bystander effect. Replication-competent murine leukemia virus (MLV has been described to have potential as cancer therapeutics, however, MLV infection does not cause a cytopathic effect in the infected cell and viral replication can only be studied by immunostaining or measurement of reverse transcriptase activity. Results We inserted the coding sequences for green fluorescent protein (GFP into the proline-rich region (PRR of the ecotropic envelope protein (Env and were able to fluorescently label MLV. This allowed us to directly monitor viral replication and attachment to target cells by flow cytometry. We used this method to study viral replication of recombinant MLVs and split viral genomes, which were generated by replacement of the MLV env gene with the red fluorescent protein (RFP and separately cloning GFP-Env into a retroviral vector. Co-transfection of both plasmids into target cells resulted in the generation of semi-replicative vectors, and the two color labeling allowed to determine the distribution of the individual genomes in the target cells and was indicative for the occurrence of recombination events. Conclusions Fluorescently labeled MLVs are excellent tools for the study of factors that influence viral replication and can be used to optimize MLV-based replication-competent viruses or vectors for gene therapy.

  15. Digital coincidence counting (DCC) and its use in the corrections for out-of-channel gamma events in 4pi beta-gamma coincidence counting.

    Science.gov (United States)

    Keightle, J D; Watt, G C

    2002-01-01

    The digital coincidence counting system developed by NPL and ANSTO is briefly described along with its benefits in the data collection and processing for the 4pi beta-gamma coincidence counting technique of radionuclide standardization. One of these benefits is the automatic detection of and correction for out-of-channel coincidences in the Computer Discrimination method. Where the criteria for the use of the Cox-Isham/Smith correction formulae for dead times and resolving times are not met, a generalized approximation based on the work of Campion is suggested.

  16. Obesidade e asma: associação ou coincidência? Obesity and asthma: association or coincidence?

    Directory of Open Access Journals (Sweden)

    Daniella Fernandes Camilo

    2010-02-01

    Full Text Available OBJETIVO: A asma e a obesidade estão entre as maiores causas de morbidade na infância e adolescência. A obesidade precoce aumenta as chances de doenças crônicas degenerativas no adulto. Embora a concomitância de ambas as situações clínicas vem sendo demonstrada em vários estudos, os mecanismos intrínsecos dessa associação ainda são pouco conhecidos. Portanto, o objetivo deste artigo foi revisar os principais trabalhos sobre a associação de obesidade e asma e verificar se existe relação de causa e efeito entre ambas. FONTES DOS DADOS: Revisão sistemática baseada em bases de dados indexadas MEDLINE (PubMed e SciELO. Foram revisados artigos originais (transversal, caso-controle e prospectivo e meta-análises publicados no período de janeiro de 1998 a janeiro de 2008. Foram pesquisados estudos divulgados em língua inglesa, espanhola e portuguesa. SÍNTESE DOS DADOS: Embora existam muitos estudos sobre as crescentes prevalências da asma e da obesidade, poucos estabelecem relações de causa e efeito entre ambas. Os mecanismos fisiopatológicos e os fatores envolvidos nesse processo ainda são pouco conhecidos. CONCLUSÃO: O rigor metodológico em estudos futuros deverá buscar respostas para melhor entender se existe associação entre asma e obesidade, ou se a relação entre ambas as doenças é coincidência.OBJECTIVE: Asthma and obesity are among the major causes of morbidity in childhood and adolescence. Early obesity increases the chances of chronic degenerative diseases in adults. Although the concomitance or both clinical situations are being demonstrated in various studies, the intrinsic mechanisms of this association are still very little known. Therefore, the objective of this article was to review the main studies on the association of obesity and asthma and check if there is a cause-effect relation between them. SOURCES: Systematic review based on indexed data bases MEDLINE (PubMed and SciELO. Original articles

  17. The coincidence of IgA nephropathy and Fabry disease

    Directory of Open Access Journals (Sweden)

    Maixnerová Dita

    2013-01-01

    Full Text Available Abstract Background IgA nephropathy (IgAN is the most common glomerulonephritis, which may also coexist with other diseases. We present two patients with an unusual coincidence of IgAN and Fabry disease (FD. Case presentation A 26 year-old man underwent a renal biopsy in February 2001. Histopathology showed very advanced IgAN and vascular changes as a result of hypertension. Because of his progressive renal insufficiency the patient began hemodialysis in August 2001. By means of the blood spot test screening method the diagnosis of FD was suspected. Low activity of alpha-galactosidase A in the patient’s plasma and leukocytes and DNA analysis confirmed the diagnosis of FD. Enzyme replacement therapy started in July 2004. Then the patient underwent kidney transplantation in November 2005. Currently, his actual serum creatinine level is 250 μmol/l. Other organ damages included hypertrophic cardiomyopathy, neuropathic pain and febrile crisis. After enzyme replacement therapy, myocardial hypertrophy has stabilized and other symptoms have disappeared. No further progression of the disease has been noted. The other patient, a 30 year-old woman, suffered from long-term hematuria with a good renal function. Recently, proteinuria (2.6 g/day appeared and a renal biopsy was performed. Histopathology showed IgAN with remarkably enlarged podocytes. A combination of IgAN and a high suspicion of FD was diagnosed. Electron microscopy revealed dense deposits in paramesangial areas typical for IgAN and podocytes with inclusive zebra bodies and myelin figures characteristic of FD. FD was confirmed by the decreased alpha-galactosidase A activity in plasma and leukocytes and by DNA and RNA analysis. Enzyme replacement therapy and family screening were initiated. Conclusions Our results emphasize the role of complexity in the process of diagnostic evaluation of kidney biopsy samples. Electron microscopy represents an integral part of histopathology, and genetic

  18. The basis for design of a DSP-based coincidence spectrometer

    CERN Document Server

    Khang, Pham Dinh; Dien, Nguyen Nhi; Tuan, Pham Ngoc; Lanh, Dang; Hoa, Nguyen Duc; Son, Nguyen An

    2013-01-01

    Coincidence technique and the coincidence measurement systems have been developed and applied for over 40 years. Most of popular coincidence measurement systems were based on analog electronics techniques such as time to amplitude conversion (TAC) or logic selecting coincidence unit. The above-mentioned systems are relatively cumbersome and complicated to use. With the strong growth of digital electronics techniques and computational science, the coincidence measurement systems will be constructed simpler but more efficient with the sake of application. This article presents the design principle and signal processing of a simple two-channel coincidence system by a new technique called Digital Signal Processing (DSP) using Field Programmable Gate Arrays (FPGA) devices at Nuclear Research Institute (NRI), Dalat.

  19. The basis for design and manufacture of a dsp-based coincidence spectrometer

    CERN Document Server

    Hai, N X; Dien, N N; Lanh, D; Huong, T T T; Khang, P D

    2013-01-01

    The coincidence technique and the coincidence spectroscopy have been developed and applied for over 40 years. Most of popular coincidence measurement systems were based on analog electronics techniques such as time to amplitude conversion (TAC) or logic selecting coincidence unit. The above-mentioned systems are relatively cumbersome and complicated to use. With the strong growth of digital electronics techniques and computational science, the coincidence measurement systems will be constructed simpler but more efficient with the sake of application. This article presents the design principle and signal processing of a simple two-channel coincidence system by a technique of Digital Signal Processing (DSP) using Field Programmable Gate Arrays (FPGA) devices at Nuclear Research Institute (NRI), Dalat.

  20. Coincidence and covariance data acquisition in photoelectron and -ion spectroscopy. II. Analysis and applications

    Science.gov (United States)

    Mikosch, Jochen; Patchkovskii, Serguei

    2013-10-01

    We use an analytical theory of noisy Poisson processes, developed in the preceding companion publication, to compare coincidence and covariance measurement approaches in photoelectron and -ion spectroscopy. For non-unit detection efficiencies, coincidence data acquisition (DAQ) suffers from false coincidences. The rate of false coincidences grows quadratically with the rate of elementary ionization events. To minimize false coincidences for rare event outcomes, very low event rates may hence be required. Coincidence measurements exhibit high tolerance to noise introduced by unstable experimental conditions. Covariance DAQ on the other hand is free of systematic errors as long as stable experimental conditions are maintained. In the presence of noise, all channels in a covariance measurement become correlated. Under favourable conditions, covariance DAQ may allow orders of magnitude reduction in measurement times. Finally, we use experimental data for strong-field ionization of 1,3-butadiene to illustrate how fluctuations in experimental conditions can contaminate a covariance measurement, and how such contamination can be detected.

  1. Reviews in fluorescence 2010

    CERN Document Server

    Geddes, Chris D

    2011-01-01

    ""Reviews in Fluorescence 2010"", the seventh volume of the book serial from Springer, serves as a comprehensive collection of current trends and emerging hot topics in the field of fluorescence and closely related disciplines. It summarizes the year's progress in fluorescence and its applications, with authoritative analytical reviews specialized enough to be attractive to professional researchers, yet also appealing to the wider audience of scientists in related disciplines of fluorescence. ""Reviews in Fluorescence"" offers an essential reference material for any lab working in the fluoresc

  2. Principles of fluorescence techniques

    CERN Document Server

    2016-01-01

    Fluorescence techniques are being used and applied increasingly in academics and industry. The Principles of Fluorescence Techniques course will outline the basic concepts of fluorescence techniques and the successful utilization of the currently available commercial instrumentation. The course is designed for students who utilize fluorescence techniques and instrumentation and for researchers and industrial scientists who wish to deepen their knowledge of fluorescence applications. Key scientists in the field will deliver theoretical lectures. The lectures will be complemented by the direct utilization of steady-state and lifetime fluorescence instrumentation and confocal microscopy for FLIM and FRET applications provided by leading companies.

  3. Studies on the true coincidence correction in measuring filter samples by gamma spectrometry

    CERN Document Server

    Lian Qi; Chang Yong Fu; Xia Bing

    2002-01-01

    The true coincidence correction in measuring filter samples has been studied by high efficiency HPGe gamma detectors. The true coincidence correction for a specific three excited levels de-excitation case has been analyzed, and the typical analytical expressions of true coincidence correction factors have been given. According to the measured relative efficiency on the detector surface with 8 'single' energy gamma emitters and efficiency of filter samples, the peak and total efficiency surfaces are fitted. The true coincidence correction factors of sup 6 sup 0 Co and sup 1 sup 5 sup 2 Eu calculated by the efficiency surfaces agree well with experimental results

  4. Error Analysis of Radar Coincidence Imaging in the Presence of Noise

    Directory of Open Access Journals (Sweden)

    Dai Qiang

    2014-10-01

    Full Text Available Radar coincidence imaging is a new method for high-resolution staring imaging. First, the mathematical model is constructed. Second, the theoretical error for radar coincidence imaging in the presence of noise is derived using the parametric imaging method. Third, the factors that affect the error are analyzed. Fourth, the sparse reconstruction algorithm is used to perform numerical simulations of radar coincidence imaging with different parameters. Finally, the effects of signal bandwidth, array configuration, size of the imaging unit, and target complexity on image error in the presence of noise are discussed. This study provides the theoretical framework for parameters selection and SNR requirements for radar coincidence imaging systems.

  5. Fluorescence correlation spectroscopy

    NARCIS (Netherlands)

    Hink, M.A.; Verveer, P.J.

    2015-01-01

    Fluorescence fluctuation spectroscopy techniques allow the quantification of fluorescent molecules present at the nanomolar concentration level. After a brief introduction to the technique, this chapter presents a protocol including background information in order to measure and quantify the molecul

  6. Safe biodegradable fluorescent particles

    Science.gov (United States)

    Martin, Sue I.; Fergenson, David P.; Srivastava, Abneesh; Bogan, Michael J.; Riot, Vincent J.; Frank, Matthias

    2010-08-24

    A human-safe fluorescence particle that can be used for fluorescence detection instruments or act as a safe simulant for mimicking the fluorescence properties of microorganisms. The particle comprises a non-biological carrier and natural fluorophores encapsulated in the non-biological carrier. By doping biodegradable-polymer drug delivery microspheres with natural or synthetic fluorophores, the desired fluorescence can be attained or biological organisms can be simulated without the associated risks and logistical difficulties of live microorganisms.

  7. "Color Timer" mice: visualization of neuronal differentiation with fluorescent proteins

    Directory of Open Access Journals (Sweden)

    Kanki Hiroaki

    2010-02-01

    green. This two-color initial version of the "Color Timer" mouse system will provide a powerful new tool for neurogenesis research.

  8. Coincidence Point Theorems, Intersection Theorems and Saddle Point Theorems on FC-spaces

    Institute of Scientific and Technical Information of China (English)

    PIAO YONG-JIE; YIN ZHE

    2009-01-01

    In this paper, we first give the definitions of finitely continuous topological space and FC-subspace generated by some set, and obtain coincidence point theorem, whole intersection theorems and Ky Fan type matching theorems, and finally discuss the existence of saddle point as an application of coincidence point theorem.

  9. On coincidence problem and attractor solutions in ELKO dark energy model

    CERN Document Server

    Sadjadi, H Mohseni

    2011-01-01

    We study the critical points of a Universe dominated by ELKO spinor field dark energy and a barotropic matter in an almost general case. The coincidence problem and attractor solutions are discussed and it is shown the coincidence problem can not be alleviated in this model.

  10. Differential coincidence circuit in the 10{sup -10} second region (1960); Circuit de coincidence differentiel dans le domaine de 10{sup -10} seconde (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Van Zurk, R. [Commissariat a l' Energie Atomique, Lab. de Physique Nucleaire, Grenoble (France).Centre d' Etudes Nucleaires]|[Grenoble-1 Univ., 38 (France)]|[Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1960-07-01

    A coincidence circuit of low resolution time using the differential coincidence Bay principle is described. It uses three 6BN6 tubes ordered to chronotron structure. Results with Radiotechnique 56 AVP photomultipliers and for {sup 60}Co {gamma}-{gamma} coincidences are 4,6.10{sup -10} s (full width at half maximum) if the efficiency is {epsilon} = 40 per cent and also 7,2.10{sup -10} s if {epsilon} = 85 per cent. (author) [French] Un circuit de coincidence differentiel du type de Bay, utilise en selecteur en temps a canal mobile, a ete construit pour la mesure des periodes {gamma} et des periodes d'annihilation du positon dans differents materiaux. Il comporte trois tubes 6BN6 disposes en structure chronotron. On a utilise les nouveaux photomultiplicateurs 56 AVP avec scintillateur plastique. Avec les coincidences {gamma}-{gamma} du {sup 60}Co, on obtient 2T 4,6.10{sup -10} s avec une efficacite de 40 pour cent et 2T = 7,2.10{sup -10} s avec une efficacite de 85 pour cent. (auteur)

  11. Experimental evidence for extreme surface sensitivity in Auger-Photoelectron Coincidence Spectroscopy (APECS) from solids

    Energy Technology Data Exchange (ETDEWEB)

    Liscio, A.; Gotter, R.; Ruocco, A.; Iacobucci, S.; Danese, A.G.; Bartynski, R.A.; Stefani, G

    2004-07-01

    Core hole creation and subsequent Auger decay processes are studied with unprecedented discrimination by Auger-Photoelectron Coincidence Spectroscopy (APECS). Early works in this field have already pointed out the intrinsic surface sensitivity of these experiments. However, it was not until recently that a model calculation was developed to quantitatively evaluate it. Here we present the first attempt to experimentally establish an effective target thickness for such experiments. The angular distribution of 3p{sub 3/2} photoelectron with kinetic energy of 160 eV is measured in coincidence with the M{sub 3}VV Auger electron with kinetic energy of 55 eV on a Cu (1 1 1) surface. Coincidence and non-coincidence photoelectron angular distributions display differences that, to large extent, are explained by confining the source of the coincident signal within the first two layers of Cu target, thus establishing an experimental upper limit for the effective target thickness of the APECS experiment.

  12. Tight bounds for the Pearle-Braunstein-Caves chained inequality without the fair-coincidence assumption

    Science.gov (United States)

    Jogenfors, Jonathan; Larsson, Jan-Åke

    2017-08-01

    In any Bell test, loopholes can cause issues in the interpretation of the results, since an apparent violation of the inequality may not correspond to a violation of local realism. An important example is the coincidence-time loophole that arises when detector settings might influence the time when detection will occur. This effect can be observed in many experiments where measurement outcomes are to be compared between remote stations because the interpretation of an ostensible Bell violation strongly depends on the method used to decide coincidence. The coincidence-time loophole has previously been studied for the Clauser-Horne-Shimony-Holt and Clauser-Horne inequalities, but recent experiments have shown the need for a generalization. Here, we study the generalized "chained" inequality by Pearle, Braunstein, and Caves (PBC) with N ≥2 settings per observer. This inequality has applications in, for instance, quantum key distribution where it has been used to reestablish security. In this paper we give the minimum coincidence probability for the PBC inequality for all N ≥2 and show that this bound is tight for a violation free of the fair-coincidence assumption. Thus, if an experiment has a coincidence probability exceeding the critical value derived here, the coincidence-time loophole is eliminated.

  13. Coincidence Properties for Maps from the Torus to the Klein Bottle

    Institute of Scientific and Technical Information of China (English)

    Daciberg L. GON(C)ALVES; Michael R. KELLY

    2008-01-01

    The authors study the coincidence theory for pairs of maps from the Torus to the Klein bottle. Reidemeister classes and the Nielsen number are computed, and it is shown that any given pair of maps satisfies the Wecken property. The 1-parameter Wecken property is studied and a partial negative answer is derived. That is for all pairs of coincidence free maps a countable family of pairs of maps in the homotopy class is constructed such that no two members may be joined by a coincidence free homotopy.

  14. Application of length vernier in phase coincidence detection and precision frequency measurement.

    Science.gov (United States)

    Miao, Miao; Wei, Zhou; Bin, Wang

    2012-02-01

    For comparison of arbitrary frequency signals, the paper proposed two levels of length vernier based on the time-space relationship are used in three levels of phase coincidence detecting circuits to extract the phase coincidence information by proper logic calculation. The length∕phase of each vernier is respectively corresponding to the accuracy and the resolution of detecting circuit. The time-space relationship is based on high-stability, high-accuracy, and high-speed of signal transmission. The method is effective to reduce the fuzzy region in the phase coincidence information and reach a higher measuring precision.

  15. Determination of the time resolution for neutron scintillation detectors by multi-coincidence measurement

    Institute of Scientific and Technical Information of China (English)

    LI Yong-Ming; RUAN Xi-Chao; ZHOU Sin; MA Zhong-Yuan

    2011-01-01

    Based on the multi-coincidence measurement, the time resolution of three liquid scintillation detectors (BC501A) were determined strictly by solving the coincidence equations, where the influence from electronics estimated by self coincidence measurement as well as the background had been considered. The result of this work agreed well with the result that was deduced from the traditional method, and it will be helpful to analyze the energy resolution of neutron time of flight spectra measured by using such detectors at CIAE (China Institute of Atomic Energy).

  16. Conventional fluorescence microscopy below the diffraction limit with simultaneous capture of two fluorophores in DNA origami

    Science.gov (United States)

    Glasgow, Ben J.

    2016-02-01

    A conventional fluorescence microscope was previously constructed for simultaneous imaging of two colors to gain sub-diffraction localization. The system is predicated on color separation of overlapping Airy discs, construction of matrices of Cartesian coordinates to determine locations as well as centers of the point spread functions of fluorophores. Quantum dots that are separated by as little as 10 nm were resolved in the x-y coordinates. Inter-fluorophore distances that vary by 10 nm could also be distinguished. Quantum dots are bright point light source emitters that excite with a single laser and can serve as a label for many biomolecules. Here, alterations in the method are described to test the ability to resolve Atto 488 and Atto 647 dyes attached to DNA origami at ~40 nm spacing intervals. Dual laser excitation is used in tandem with multi-wavelength bandpass filters. Notwithstanding challenges from reduced intensity in Atto labeled DNA origami helical bundles compared to quantum dots, preliminary data show a mean inter-fluorophore distance of 56 nm with a range (14-148 nm). The range closely matches published results with DNA origami with other methods of subdiffraction microscopy. Sub-diffraction simultaneous two-color imaging fluorescence microscopy acronymically christened (SSTIFM) is a simple, readily accessible, technique for measurement of inter-fluorophore distances in compartments less than 40 nm. Preliminary results with so called nanorulers are encouraging for use with other biomolecules.

  17. Comparison of satellite reflectance algorithms for estimating chlorophyll-a in a temperate reservoir using coincident hyperspectral aircraft imagery and dense coincident surface observations

    Science.gov (United States)

    We analyzed 10 established and 4 new satellite reflectance algorithms for estimating chlorophyll-a (Chl-a) in a temperate reservoir in southwest Ohio using coincident hyperspectral aircraft imagery and dense water truth collected within one hour of image acquisition to develop si...

  18. Comparison of satellite reflectance algorithms for estimating chlorophyll-a in a temperate reservoir using coincident hyperspectral aircraft imagery and dense coincident surface observations

    Science.gov (United States)

    We analyzed 10 established and 4 new satellite reflectance algorithms for estimating chlorophyll-a (Chl-a) in a temperate reservoir in southwest Ohio using coincident hyperspectral aircraft imagery and dense water truth collected within one hour of image acquisition to develop si...

  19. Investigation of two-color magneto-optical trap with cesium 6S1/2-6P3/2-7S1/2 ladder-type system

    CERN Document Server

    Wang, Jie; Yang, Baodong; He, Jun; Wang, Junmin

    2016-01-01

    A novel cesium (Cs) two-color magneto-optical trap (TC-MOT), which partially employs the optical radiation forces due to photon scattering of the 6P3/2 (F'=5) - 7S1/2 (F"=4) excited-state transition in the Cs 6S1/2 - 6P3/2 - 7S1/2 (852 + 1470 nm) ladder-type system, has been proposed and experimentally investigated. One of the three pairs of 852 nm cooling/trapping beams (CTBs) in a conventional Cs MOT is replaced with a pair of the 1470 nm CTBs (type-I) or with one 852 nm CTB plus another counter-propagating 1470 nm CTB (type-II). Both the type-I and type-II Cs TC-MOTs can cool and trap atoms on both the red- and blue-detuning sides of the two-photon resonance. The Cs TC-MOT demonstrated in this work may have applications in the background-free detection of cooled and trapped atoms, and the photon-pair sources compatible with the ensemble-based quantum memory and the long-distance quantum communication via optical fiber.

  20. 双色场诱导气体产生相干可控的四次谐波∗%Coherently controlled fourth harmonic generation in gases induced by a two-color field

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Induced by the harmonically related two-color pulse, the fourth harmonic wave in the vacuum ultraviolet range has been observed in gases. The process of the fourth harmonic generation is studied. In the case of non-ionized gas, the intensity dependence on the pump pulse reveals that the fourth harmonic generation is a third-order parametric process of 2ω+ω+ω → 4ω. In the case of ionized gas, the intensity of the fourth harmonic wave can be coherently controlled by the relative phase of the pump. Employing synchronous measurements of the fourth-order harmonic and terahertz emissions, the optimized relative phases of the two emissions have been studied and compared with each other experimentally. Results agree well with those of the time-dependent Schrödinger equation (TDSE). According to the reported optimized phase for the terahertz generation, the fourth harmonic generation involves two parametric processes:2ω+2ω±ΩTHz →4ω and 2ω+ω+ω →4ω. The modulation of the fourth harmonic wave can be understood as the interference of the two channels.

  1. Laser radiation frequency conversion in carbon- and cluster-containing plasma plumes under conditions of single and two-color pumping by pulses with a 10-Hz repetition rate

    Science.gov (United States)

    Ganeev, R. A.

    2013-07-01

    This work reviews a series of investigations of different plasma plumes using single- and two-color laser systems that emit femtosecond pulses with a 10-Hz repetition rate. Results of investigation of the resonant enhancement of harmonics in tin plasma with the use of two types of pumps are analyzed, and it is shown that the tuning of the wavelengths of harmonics to ion-resonance levels plays an important role in increasing the conversion efficiency to high-order harmonics of the radiation to be converted. Investigations of different carbon-containing plasma media (carbon nanotubes, graphite, carbon aerogel, etc.) exhibit attractive properties of the nonlinear medium of this type for efficient generation of high-order harmonics. The results of the first experiments on the use of nanoparticles produced directly in the course of laser ablation of metals for increasing the efficiency of harmonics generated in this cluster-containing medium are analyzed. It is shown that new approaches realized in these investigations give hope that the nonlinear optical response of plasma media in the far-ultraviolet range can be further increased.

  2. High proportion of smaller ranged hummingbird species coincides with ecological specialization across the Americas

    DEFF Research Database (Denmark)

    Sonne, Jesper; Martín González, Ana M.; Maruyama, Pietro K.

    2016-01-01

    Ecological communities that experience stable climate conditions have been speculated to preserve more specialized interspecific associations and have higher proportions of smaller ranged species (SRS). Thus, areas with disproportionally large numbers of SRS are expected to coincide geographicall...

  3. Coincidence and covariance data acquisition in photoelectron and -ion spectroscopy. I. Formal theory

    Science.gov (United States)

    Mikosch, Jochen; Patchkovskii, Serguei

    2013-10-01

    We derive a formal theory of noisy Poisson processes with multiple outcomes. We obtain simple, compact expressions for the probability distribution function of arbitrarily complex composite events and its moments. We illustrate the utility of the theory by analyzing properties of coincidence and covariance photoelectron-photoion detection involving single-ionization events. The results and techniques introduced in this work are directly applicable to more general coincidence and covariance experiments, including multiple ionization and multiple-ion fragmentation pathways.

  4. Direction of an approaching stimulus on coincident timing performance of a ballistic striking task.

    Science.gov (United States)

    Coker, Cheryl A

    2005-06-01

    The purpose of this study was to explore the influence of stimulus direction and velocity on the coincident timing performance of a ballistic striking task. 26 subjects randomly performed 20 trials at each of two stimulus velocities (4 and 8 mph) and two striking variations (moving with an approaching stimulus or in opposition to it). Analysis indicated the direction of an approaching stimulus does not appear to influence the coincident timing of a ballistic striking action.

  5. On Approximate Coincidence Point Properties and Their Applications to Fixed Point Theory

    OpenAIRE

    Wei-Shih Du

    2012-01-01

    We first establish some existence results concerning approximate coincidence point properties and approximate fixed point properties for various types of nonlinear contractive maps in the setting of cone metric spaces and general metric spaces. From these results, we present some new coincidence point and fixed point theorems which generalize Berinde-Berinde's fixed point theorem, Mizoguchi-Takahashi's fixed point theorem, and some well-known results in the literature.

  6. Low level radioactivity measurements with phoswich detectors using coincident techniques and digital pulse processing analysis

    Energy Technology Data Exchange (ETDEWEB)

    Fuente, R. de la [University of Leon, Escuela de Ingenieria Industrial, Leon 24071 (Spain); Celis, B. de [University of Leon, Escuela de Ingenieria Industrial, Leon 24071 (Spain)], E-mail: bcelc@unileon.es; Canto, V. del; Lumbreras, J.M. [University of Leon, Escuela de Ingenieria Industrial, Leon 24071 (Spain); Celis, Alonso B. de [King' s College London, IoP, De Crespigny Park, SE58AF (United Kingdom); Martin-Martin, A. [Laboratorio LIBRA, Edificio I-D, Paseo Belen 3. 47011 Valladolid (Spain); Departamento de Fisica Teorica, Atomica y Optica, Facultad de Ciencias. Po Prado de la Magdalena, s/n. 47005 Valladolid (Spain)], E-mail: alonsomm@libra.uva.es; Gutierrez-Villanueva, J.L. [Laboratorio LIBRA, Edificio I-D, Paseo Belen 3. 47011 Valladolid (Spain); Departamento de Fisica Teorica, Atomica y Optica, Facultad de Ciencias. Po Prado de la Magdalena, s/n. 47005 Valladolid (Spain)], E-mail: joselg@libra.uva.es

    2008-10-15

    A new system has been developed for the detection of low radioactivity levels of fission products and actinides using coincidence techniques. The device combines a phoswich detector for {alpha}/{beta}/{gamma}-ray recognition with a fast digital card for electronic pulse analysis. The phoswich can be used in a coincident mode by identifying the composed signal produced by the simultaneous detection of {alpha}/{beta} particles and X-rays/{gamma} particles. The technique of coincidences with phoswich detectors was proposed recently to verify the Nuclear Test Ban Treaty (NTBT) which established the necessity of monitoring low levels of gaseous fission products produced by underground nuclear explosions. With the device proposed here it is possible to identify the coincidence events and determine the energy and type of coincident particles. The sensitivity of the system has been improved by employing liquid scintillators and a high resolution low energy germanium detector. In this case it is possible to identify simultaneously by {alpha}/{gamma} coincidence transuranic nuclides present in environmental samples without necessity of performing radiochemical separation. The minimum detectable activity was estimated to be 0.01 Bq kg{sup -1} for 0.1 kg of soil and 1000 min counting.

  7. Fluorescence antibunching microscopy

    CERN Document Server

    Schwartz, Osip

    2011-01-01

    Breaking the diffraction limit in microscopy by utilizing quantum properties of light has been the goal of intense research in the recent years. We propose a quantum superresolution technique based on non-classical emission statistics of fluorescent markers, routinely used as contrast labels for bio-imaging. The technique can be readily implemented using standard fluorescence microscopy equipment.

  8. Fluorescence of atopic allergens

    NARCIS (Netherlands)

    Berrens, L.

    1967-01-01

    Purified atopic allergens have been found to emit flue fluorescence upon irradiation with ultraviolet light of 365 mμ wavelength. The maximum of fluorescence is in the region 445–490 mμ and the intensity is of the same order of magnitude for different atopic allergens. Synthetic model compounds, inc

  9. Fluorescent Lamp Replacement Study

    Science.gov (United States)

    2017-07-01

    Light-emitting diode, LED, lighting, fluorescent, waste reduction, energy conservation, net zero , mercury 16. SECURITY CLASSIFICATION OF: 17. LIMITATION...Center (ATC) to assess the benefits of converting fluorescent tube lighting to light-emitting diode (LED) technology. The report documents the waste ...1-15 SECTION 2. SUBTESTS 2.1 HAZARDOUS WASTE REDUCTION

  10. LEDs for fluorescence microscopy

    NARCIS (Netherlands)

    Young, I.T.; Garini, Y.; Dietrich, H.R.C.; Van Oel, W.; Liqui Lung, G.

    2004-01-01

    Traditional light sources for fluorescence microscopy have been mercury lamps, xenon lamps, and lasers. These sources have been essential in the development of fluorescence microscopy but each can have serious disadvantages: lack of near monochromaticity, heat generation, cost, lifetime of the light

  11. Miniaturized fluorescent RNA dot blot method for rapid quantitation of gene expression

    Directory of Open Access Journals (Sweden)

    Yadetie Fekadu

    2004-06-01

    Full Text Available Abstract Background RNA dot blot hybridization is a commonly used technique for gene expression assays. However, membrane based RNA dot/slot blot hybridization is time consuming, requires large amounts of RNA, and is less suited for parallel assays of more than one gene at a time. Here, we describe a glass-slide based miniaturized RNA dot blot (RNA array procedure for rapid and parallel gene expression analysis using fluorescently labeled probes. Results RNA arrays were prepared by simple manual spotting of RNA onto amino-silane coated microarray glass slides, and used for two-color fluorescent hybridization with specific probes labeled with Cy3 and 18S ribosomal RNA house-keeping gene probe labeled with Cy5 fluorescent dyes. After hybridization, arrays were scanned on a fluorescent microarray scanner and images analyzed using microarray image analysis software. We demonstrate that this method gives comparable results to Northern blot analysis, and enables high throughput quantification of transcripts from nanogram quantities of total RNA in hundreds of samples. Conclusion RNA array on glass slide and detection by fluorescently labeled probes can be used for rapid and parallel gene expression analysis. The method is particularly well suited for gene expression assays that involve quantitation of many transcripts in large numbers of samples.

  12. A region of euchromatin coincides with an extensive tandem repeat on the mouse (Mus musculus) inactive X chromosome.

    Science.gov (United States)

    Darrow, Emily M; Seberg, Andrew P; Das, Sunny; Figueroa, Debbie M; Sun, Zhuo; Moseley, Shawn C; Chadwick, Brian P

    2014-09-01

    Euchromatic features are largely absent from the human inactive X chromosome (Xi), with the exception of several large tandem repeats that can be detected as euchromatin bands at metaphase. Despite residing megabases apart, these tandem repeats make frequent inactive X-specific interactions. The mouse homologue has been reported for at least one of the tandem repeats, but whether the mouse Xi is also characterized by distinct bands of euchromatin remains unknown. We examined the mouse Xi for the presence of euchromatin bands by examining the pattern of histone H3 dimethylated at lysine 4 and detected two major signals. The first band resides in the subtelomeric region of band XF5 and may correspond to the pseudoautosomal region. The second band localizes to XE3 and coincides with an extensive complex repeat composed of a large tandem and inverted repeat segment as well as several large short interspersed nuclear element (SINE)-rich tandem repeats. Fluorescence in situ hybridization reveals that sequences with homology to the repeat region are scattered along the length of the Y chromosome. Immunofluorescence analysis of histone H3 trimethylated at lysine 9 on metaphase chromosomes indicates that the repeat region corresponds to a band of constitutive heterochromatin on the male X and female active X chromosomes, whereas the euchromatin signal appears to be female specific. These data suggest that the band of euchromatin observed at XE3 is unique to the mouse Xi, comparable to the chromatin arrangement of several large tandem repeats located on the human X chromosome.

  13. Fluorescence and Spectral Imaging

    Directory of Open Access Journals (Sweden)

    Ralph S. DaCosta

    2007-01-01

    Full Text Available Early identification of dysplasia remains a critical goal for diagnostic endoscopy since early discovery directly improves patient survival because it allows endoscopic or surgical intervention with disease localized without lymph node involvement. Clinical studies have successfully used tissue autofluorescence with conventional white light endoscopy and biopsy for detecting adenomatous colonic polyps, differentiating benign hyperplastic from adenomas with acceptable sensitivity and specificity. In Barrett's esophagus, the detection of dysplasia remains problematic because of background inflammation, whereas in the squamous esophagus, autofluorescence imaging appears to be more dependable. Point fluorescence spectroscopy, although playing a crucial role in the pioneering mechanistic development of fluorescence endoscopic imaging, does not seem to have a current function in endoscopy because of its nontargeted sampling and suboptimal sensitivity and specificity. Other point spectroscopic modalities, such as Raman spectroscopy and elastic light scattering, continue to be evaluated in clinical studies, but still suffer the significant disadvantages of being random and nonimaging. A recent addition to the fluorescence endoscopic imaging arsenal is the use of confocal fluorescence endomicroscopy, which provides real-time optical biopsy for the first time. To improve detection of dysplasia in the gastrointestinal tract, a new and exciting development has been the use of exogenous fluorescence contrast probes that specifically target a variety of disease-related cellular biomarkers using conventional fluorescent dyes and novel potent fluorescent nanocrystals (i.e., quantum dots. This is an area of great promise, but still in its infancy, and preclinical studies are currently under way.

  14. Analysis of calibration data for the uranium active neutron coincidence counting collar with attention to errors in the measured neutron coincidence rate

    Energy Technology Data Exchange (ETDEWEB)

    Croft, Stephen [Oak Ridge National Laboratory (ORNL), One Bethel Valley Road, Oak Ridge, TN (United States); Burr, Tom [International Atomic Energy Agency (IAEA), Vienna (Austria); Favalli, Andrea [Los Alamos National Laboratory (LANL), MS E540, Los Alamos, NM 87545 (United States); Nicholson, Andrew [Oak Ridge National Laboratory (ORNL), One Bethel Valley Road, Oak Ridge, TN (United States)

    2016-03-01

    The declared linear density of {sup 238}U and {sup 235}U in fresh low enriched uranium light water reactor fuel assemblies can be verified for nuclear safeguards purposes using a neutron coincidence counter collar in passive and active mode, respectively. The active mode calibration of the Uranium Neutron Collar – Light water reactor fuel (UNCL) instrument is normally performed using a non-linear fitting technique. The fitting technique relates the measured neutron coincidence rate (the predictor) to the linear density of {sup 235}U (the response) in order to estimate model parameters of the nonlinear Padé equation, which traditionally is used to model the calibration data. Alternatively, following a simple data transformation, the fitting can also be performed using standard linear fitting methods. This paper compares performance of the nonlinear technique to the linear technique, using a range of possible error variance magnitudes in the measured neutron coincidence rate. We develop the required formalism and then apply the traditional (nonlinear) and alternative approaches (linear) to the same experimental and corresponding simulated representative datasets. We find that, in this context, because of the magnitude of the errors in the predictor, it is preferable not to transform to a linear model, and it is preferable not to adjust for the errors in the predictor when inferring the model parameters.

  15. Highly thermostable fluorescent proteins

    Science.gov (United States)

    Bradbury, Andrew M [Santa Fe, NM; Waldo, Geoffrey S [Santa Fe, NM; Kiss, Csaba [Los Alamos, NM

    2012-05-01

    Thermostable fluorescent proteins (TSFPs), methods for generating these and other stability-enhanced proteins, polynucleotides encoding such proteins, and assays and method for using the TSFPs and TSFP-encoding nucleic acid molecules are provided. The TSFPs of the invention show extremely enhanced levels of stability and thermotolerance. In one case, for example, a TSFP of the invention is so stable it can be heated to 99.degree. C. for short periods of time without denaturing, and retains 85% of its fluorescence when heated to 80.degree. C. for several minutes. The invention also provides a method for generating stability-enhanced variants of a protein, including but not limited to fluorescent proteins.

  16. Highly thermostable fluorescent proteins

    Science.gov (United States)

    Bradbury, Andrew M.; Waldo, Geoffrey S.; Kiss, Csaba

    2011-03-22

    Thermostable fluorescent proteins (TSFPs), methods for generating these and other stability-enhanced proteins, polynucleotides encoding such proteins, and assays and method for using the TSFPs and TSFP-encoding nucleic acid molecules are provided. The TSFPs of the invention show extremely enhanced levels of stability and thermotolerance. In one case, for example, a TSFP of the invention is so stable it can be heated to 99.degree. C. for short periods of time without denaturing, and retains 85% of its fluorescence when heated to 80.degree. C. for several minutes. The invention also provides a method for generating stability-enhanced variants of a protein, including but not limited to fluorescent proteins.

  17. Recovering the triple coincidence of non-pure positron emitters in preclinical PET

    Science.gov (United States)

    Lin, Hsin-Hon; Chuang, Keh-Shih; Chen, Szu-Yu; Jan, Meei-Ling

    2016-03-01

    Non-pure positron emitters, with their long half-lives, allow for the tracing of slow biochemical processes which cannot be adequately examined by the commonly used short-lived positron emitters. Most of these isotopes emit high-energy cascade gamma rays in addition to positron decay that can be detected and create a triple coincidence with annihilation photons. Triple coincidence is discarded in most scanners, however, the majority of the triple coincidence contains true photon pairs that can be recovered. In this study, we propose a strategy for recovering triple coincidence events to raise the sensitivity of PET imaging for non-pure positron emitters. To identify the true line of response (LOR) from a triple coincidence, a framework utilizing geometrical, energy and temporal information is proposed. The geometrical criterion is based on the assumption that the LOR with the largest radial offset among the three sub pairs of triple coincidences is least likely to be a true LOR. Then, a confidence time window is used to test the valid LOR among those within triple coincidence. Finally, a likelihood ratio discriminant rule based on the energy probability density distribution of cascade and annihilation gammas is established to identify the true LOR. An Inveon preclinical PET scanner was modeled with GATE (GEANT4 application for tomographic emission) Monte Carlo software. We evaluated the performance of the proposed method in terms of identification fraction, noise equivalent count rates (NECR), and image quality on various phantoms. With the inclusion of triple coincidence events using the proposed method, the NECR was found to increase from 11% to 26% and 19% to 29% for I-124 and Br-76, respectively, when 7.4-185 MBq of activity was used. Compared to the reconstructed images using double coincidence, this technique increased the SNR by 5.1-7.3% for I-124 and 9.3-10.3% for Br-76 within the activity range of 9.25-74 MBq, without compromising the spatial resolution or

  18. New insight into the Auger decay process in O{sub 2}: The coincidence perspective

    Energy Technology Data Exchange (ETDEWEB)

    Arion, Tiberiu, E-mail: tiberiu.arion@cfel.de [Max-Planck-Institut fuer Plasmaphysik, EURATOM Association, Boltzmannstr. 2, 85748 Garching (Germany); Institut fuer Experimentalphysik, Universitaet Hamburg, Luruper Chaussee 149, 22761 Hamburg (Germany); Puettner, Ralph [Institut fuer Experimentalphysik, Freie Universitaet Berlin, Arnimallee 14, 14195 Berlin (Germany); Lupulescu, Cosmin [Technische Universitaet Berlin, Institut fuer Optik und atomare Physik, Hardenbergstr. 36, 10623 Berlin (Germany); Ovsyannikov, Ruslan [Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, 12489 Berlin (Germany); Foerstel, Marko [Max-Planck-Institut fuer Plasmaphysik, EURATOM Association, Boltzmannstr. 2, 85748 Garching (Germany); Oehrwall, Gunnar [MAX-lab, Lund University, P.O. Box 118, SE-22100 Lund (Sweden); Lindblad, Andreas [Uppsala University, Department of Physics and Astronomy, Box 516, SE-751 20 Uppsala (Sweden); Ueda, Kiyoshi [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai 980-8577 (Japan); Svensson, Svante [Uppsala University, Department of Physics and Astronomy, Box 516, SE-751 20 Uppsala (Sweden); Bradshaw, Alex M. [Max-Planck-Institut fuer Plasmaphysik, EURATOM Association, Boltzmannstr. 2, 85748 Garching (Germany); Fritz-Haber-Institut der Max-Planck-Gesellschaft, Faradayweg 4-6, 14195 Berlin (Germany); Eberhardt, Wolfgang [Technische Universitaet Berlin, Institut fuer Optik und atomare Physik, Hardenbergstr. 36, 10623 Berlin (Germany); Center for Free-Electron Laser Science, Notkestrasse 85, 22607 Hamburg (Germany); and others

    2012-09-15

    Highlights: Black-Right-Pointing-Pointer We developed a new experimental set-up for e,e-coincidence experiments. Black-Right-Pointing-Pointer New information on the potential curves of the final states in O{sub 2} has been extracted. Black-Right-Pointing-Pointer We observed new features, assigned to autoionization of neutral doubly excited states. -- Abstract: Photoelectron-Auger electron coincidence spectroscopy is a powerful tool for the investigation of Auger decay processes with different core-ionized intermediate states. In this paper we describe an investigation into the Auger decay of the O{sub 2} molecule, with the purpose of bringing new insight into the dynamics of the core hole decay mechanism. Using a novel experimental approach to measuring such coincidence spectra we report the highest resolution Auger spectrum of O{sub 2} recorded hitherto. In our approach, we have combined the advantages of these coincidence spectra with the high resolution and excellent signal-to-noise ratios of non-coincident Auger spectra and a state-of-the-art fit analysis. In this way we have derived information about the potential energy curves of the final states W {sup 3}{Delta}{sub u}, B {sup 3}{Pi}{sub g}, and B Prime {sup 3}{Sigma}{sub u}{sup -} and concluded that the corresponding Auger transitions are formed to a large part by strongly overlapping vibrational progressions. The present findings are compared to earlier results reported in the literature confirming some theoretical predictions.

  19. Introduction to fluorescence

    CERN Document Server

    Jameson, David M

    2014-01-01

    "An essential contribution to educating scientists in the principles of fluorescence. It will also be an important addition to the libraries of practitioners applying the principles of molecular fluorescence."-Ken Jacobson, Kenan Distinguished Professor of Cell Biology and Physiology, University of North Carolina at Chapel Hill"An exquisite compendium of fluorescence and its applications in biochemistry enriched by a very exciting historical perspective. This book will become a standard text for graduate students and other scientists."-Drs. Zygmunt (Karol) Gryczynski and Ignacy Gryczynski, University of North Texas Health Science Center"… truly a masterwork, combining clarity, precision, and good humor. The reader, novice or expert, will be pleased with the text and will not stop reading. It is a formidable account of the fluorescence field, which has impacted the life sciences so considerably in the last 60 years."-Jerson L. Silva, M.D., Ph.D., Professor and Director, National Institute of Science and Tech...

  20. Functional Fluorescent Organic Nanoparticles

    OpenAIRE

    Campioli, Elisa

    2013-01-01

    This thesis presents an extensive study on fluorescent organic nanoparticles and fluorescent organic binary and ternary nanoassemblies. In particular the attention is focused on the preparation and characterization of organic nanoparticles and new nanocomposites obtained from different types of small organic molecules, their stabilization and the use of these materials for biological and optoelectronics applications. The work deals at the beginning with the description of some methods used...

  1. Measurement of beta-gamma coincidence with a multi-parameter analyzer system

    Science.gov (United States)

    Yazdanpanah-Kejani, M.; Abbasi, F.; Lamehi-Rachti, M.; Doost-Mohammadi, V.

    2017-01-01

    A new version of the Iranian Noble Gas Analyzing System (INGAS) has been improved to facilitate measurement of beta-gamma coincidence events. It employs a new prototype list-mode multi-parameter data analyzer system, MPA4300. In order to test the new version performance, it has used to obtain energy spectra from radioxenon isotopes using the detector assembly of the Iranian Noble Gas Analyzing System. The MPA4300 is able to set the coinciding parameters, extract the corresponding spectrum, and through the use of event by event list file, can replay the measurement in offline mode. A great novelty of this work is the use of internal timing circuit in MPA4300 instead of using standard pick up time modules to identify coincidence events of detectors. A detailed description of the measuring 222Rn and 131mXe is presented.

  2. A DSP-based multichannel analyzer for simultaneous acquisition of coincidence and anticoincidence spectra

    Energy Technology Data Exchange (ETDEWEB)

    Byun, S.H. [Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, ON, L8S 4K1 (Canada)], E-mail: soohyun@mcmaster.ca; Chin, K.; Prestwich, W.V.; McNeill, F.E.; Chettle, D.R. [Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, ON, L8S 4K1 (Canada)

    2007-10-15

    A digital signal processor (DSP) based multichannel analyzer (MCA) has been developed for simultaneous acquisition of coincidence and anticoincidence {gamma}-ray spectra. The shaped pulse from the spectroscopy amplifier is digitized by a flash analog-to-digital converter and then processed by a DSP. The coincidence mode operation is implemented by an external gate signal from a coincidence module. Fundamental performance was tested using NaI(Tl) detectors and compared with that of a standard NIM module. The new MCA is currently used for in vivo neutron activation analysis. Further development is in preparation toward full digital processing, which is free from the remaining analog component, that is the spectroscopy amplifier.

  3. Addressing the Cosmic Coincidence Problem in f(T) Gravity Models

    CERN Document Server

    Rudra, Prabir

    2014-01-01

    In this paper we address the well-known cosmic coincidence problem in the framework of the f(T) gravity. In order to achieve this, an interaction between dark energy and dark matter is considered. A constraint equation is obtained which generates the f(T) models that do not suffer from the coincidence problem. Due to the absence of a universally accepted interaction term introduced by a fundamental theory, the study is conducted over three different forms of chosen interaction terms. As an illustration two widely known models of f(T) gravity are taken into consideration and used in the setup designed to study the problem. The study reveals that there exists a perfect solution for the coincidence problem in the background of the second model while the first model remains utterly plagued by the phenomenon. This not only shows the cosmological viability but also the superiority of the second model over its counterpart.

  4. Molecular Dynamics of XFEL-Induced Photo-Dissociation, Revealed by Ion-Ion Coincidence Measurements

    Directory of Open Access Journals (Sweden)

    Edwin Kukk

    2017-05-01

    Full Text Available X-ray free electron lasers (XFELs providing ultrashort intense pulses of X-rays have proven to be excellent tools to investigate the dynamics of radiation-induced dissociation and charge redistribution in molecules and nanoparticles. Coincidence techniques, in particular multi-ion time-of-flight (TOF coincident experiments, can provide detailed information on the photoabsorption, charge generation, and Coulomb explosion events. Here we review several such recent experiments performed at the SPring-8 Angstrom Compact free electron LAser (SACLA facility in Japan, with iodomethane, diiodomethane, and 5-iodouracil as targets. We demonstrate how to utilize the momentum-resolving capabilities of the ion TOF spectrometers to resolve and filter the coincidence data and extract various information essential in understanding the time evolution of the processes induced by the XFEL pulses.

  5. Simulations of Lithium-Based Neutron Coincidence Counter for Gd-Loaded Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Cowles, Christian C.; Kouzes, Richard T.; Siciliano, Edward R.

    2014-10-31

    The Department of Energy Office of Nuclear Safeguards and Security (NA-241) is supporting the project Lithium-Based Alternative Neutron Detection Technology Coincidence Counting for Gd-loaded Fuels at Pacific Northwest National Laboratory for the development of a lithium-based neutron coincidence counter for nondestructively assaying Gd loaded nuclear fuel. This report provides results from MCNP simulations of a lithium-based coincidence counter for the possible measurement of Gd-loaded nuclear fuel. A comparison of lithium-based simulations and UNCL-II simulations with and without Gd loaded fuel is provided. A lithium-based model, referred to as PLNS3A-R1, showed strong promise for assaying Gd loaded fuel.

  6. Application of multiparameter coincidence spectrometry using a Ge detectors array to neutron activation analysis

    CERN Document Server

    Hatsukawa, Y; Hayakawa, T; Toh, Y; Shinohara, N

    2002-01-01

    The method of multiparameter coincidence spectrometry based on gamma-gamma coincidence is widely used for the nuclear structure studies, because of its high sensitivity to gamma-rays. In this study, feasibility of the method of multiparameter coincidence spectrometry for analytical chemistry was examined. Two reference igneous rock samples (JP-1, JB-1a) issued by the Geological Survey of Japan were irradiated at a research reactor, and the gamma-rays from the radioisotopes produced via neutron capture reactions were measured using an array of 12 Ge detectors with BGO Compton suppressors, GEMINI. Simultaneously 24 elements were analyzed without chemical separation. The observed smallest component was Eu contained in JP-1 with abundance of 4 ppb.

  7. Search for transient gravitational waves in coincidence with short duration radio transients during 2007-2013

    CERN Document Server

    others,; Abbott, B P; Abbott, R; Abbott, T D; Abernathy, M R; Acernese, F; Ackley, K; Adams, C; Adams, T; Addesso, P; Adhikari, R X; Adya, V B; Affeldt, C; Agathos, M; Agatsuma, K; Aggarwal, N; Aguiar, O D; Aiello, L; Ain, A; Ajith, P; Allen, B; Allocca, A; Altin, P A; Anderson, S B; Anderson, W G; Arai, K; Araya, M C; Arceneaux, C C; Areeda, J S; Arnaud, N; Arun, K G; Ascenzi, S; Ashton, G; Ast, M; Aston, S M; Astone, P; Aufmuth, P; Aulbert, C; Babak, S; Bacon, P; Bader, M K M; Baker, P T; Baldaccini, F; Ballardin, G; Ballmer, S W; Barayoga, J C; Barclay, S E; Barish, B C; Barker, D; Barone, F; Barr, B; Barsotti, L; Barsuglia, M; Barta, D; Bartlett, J; Bartos, I; Bassiri, R; Basti, A; Batch, J C; Baune, C; Bavigadda, V; Bazzan, M; Behnke, B; Bejger, M; Bell, A S; Bell, C J; Berger, B K; Bergman, J; Bergmann, G; Berry, C P L; Bersanetti, D; Bertolini, A; Betzwieser, J; Bhagwat, S; Bhandare, R; Bilenko, I A; Billingsley, G; Birch, J; Birney, R; Biscans, S; Bisht, A; Bitossi, M; Biwer, C; Bizouard, M A; Blackburn, J K; Blair, C D; Blair, D G; Blair, R M; Bloemen, S; Bock, O; Bodiya, T P; Boer, M; Bogaert, G; Bogan, C; Bohe, A; Bojtos, P; Bond, C; Bondu, F; Bonnand, R; Boom, B A; Bork, R; Boschi, V; Bose, S; Bouffanais, Y; Bozzi, A; Bradaschia, C; Brady, P R; Braginsky, V B; Branchesi, M; Brau, J E; Briant, T; Brillet, A; Brinkmann, M; Brisson, V; Brockill, P; Brooks, A F; Brown, D A; Brown, D D; Brown, N M; Buchanan, C C; Buikema, A; Bulik, T; Bulten, H J; Buonanno, A; Buskulic, D; Buy, C; Byer, R L; Cadonati, L; Cagnoli, G; Cahillane, C; Bustillo, J Calderón; Callister, T; Calloni, E; Camp, J B; Cannon, K C; Cao, J; Capano, C D; Capocasa, E; Carbognani, F; Caride, S; Diaz, J Casanueva; Casentini, C; Caudill, S; Cavaglià, M; Cavalier, F; Cavalieri, R; Cella, G; Cepeda, C B; Baiardi, L Cerboni; Cerretani, G; Cesarini, E; Chakraborty, R; Chalermsongsak, T; Chamberlin, S J; Chan, M; Chao, S; Charlton, P; Chassande-Mottin, E; Chen, H Y; Chen, Y; Cheng, C; Chincarini, A; Chiummo, A; Cho, H S; Cho, M; Chow, J H; Christensen, N; Chu, Q; Chua, S; Chung, S; Ciani, G; Clara, F; Clark, J A; Cleva, F; Coccia, E; Cohadon, P -F; Colla, A; Collette, C G; Cominsky, L; Constancio, M; Conte, A; Conti, L; Cook, D; Corbitt, T R; Cornish, N; Corsi, A; Cortese, S; Costa, C A; Coughlin, M W; Coughlin, S B; Coulon, J -P; Countryman, S T; Couvares, P; Coward, D M; Cowart, M J; Coyne, D C; Coyne, R; Craig, K; Creighton, J D E; Cripe, J; Crowder, S G; Cumming, A; Cunningham, L; Cuoco, E; Canton, T Dal; Danilishin, S L; D'Antonio, S; Danzmann, K; Darman, N S; Dattilo, V; Dave, I; Daveloza, H P; Davier, M; Davies, G S; Daw, E J; Day, R; DeBra, D; Debreczeni, G; Degallaix, J; De Laurentis, M; Deléglise, S; Del Pozzo, W; Denker, T; Dent, T; Dergachev, V; De Rosa, R; DeRosa, R T; DeSalvo, R; Dhurandhar, S; Díaz, M C; Di Fiore, L; Di Giovanni, M; Di Girolamo, T; Di Lieto, A; Di Pace, S; Di Palma, I; Di Virgilio, A; Dojcinoski, G; Dolique, V; Donovan, F; Dooley, K L; Doravari, S; Douglas, R; Downes, T P; Drago, M; Drever, R W P; Driggers, J C; Du, Z; Ducrot, M; Dwyer, S E; Edo, T B; Edwards, M C; Effler, A; Eggenstein, H -B; Ehrens, P; Eichholz, J; Eikenberry, S S; Engels, W; Essick, R C; Etzel, T; Evans, M; Evans, T M; Everett, R; Factourovich, M; Fafone, V; Fair, H; Fairhurst, S; Fan, X; Fang, Q; Farinon, S; Farr, B; Farr, W M; Favata, M; Fays, M; Fehrmann, H; Fejer, M M; Ferrante, I; Ferreira, E C; Ferrini, F; Fidecaro, F; Fiori, I; Fiorucci, D; Fisher, R P; Flaminio, R; Fletcher, M; Fournier, J -D; Frasca, S; Frasconi, F; Frei, Z; Freise, A; Frey, R; Frey, V; Fricke, T T; Fritschel, P; Frolov, V V; Fulda, P; Fyffe, M; Gabbard, H A G; Gair, J R; Gammaitoni, L; Gaonkar, S G; Garufi, F; Gaur, G; Gehrels, N; Gemme, G; Genin, E; Gennai, A; George, J; Gergely, L; Germain, V; Ghosh, Archisman; Ghosh, S; Giaime, J A; Giardina, K D; Giazotto, A; Gill, K; Glaefke, A; Goetz, E; Goetz, R; Gondan, L; González, G; Castro, J M Gonzalez; Gopakumar, A; Gordon, N A; Gorodetsky, M L; Gossan, S E; Gosselin, M; Gouaty, R; Grado, A; Graef, C; Graff, P B; Granata, M; Grant, A; Gras, S; Gray, C; Greco, G; Green, A C; Groot, P; Grote, H; Grunewald, S; Guidi, G M; Guo, X; Gupta, A; Gupta, M K; Gushwa, K E; Gustafson, E K; Gustafson, R; Hacker, J J; Hall, B R; Hall, E D; Hammond, G; Haney, M; Hanke, M M; Hanks, J; Hanna, C; Hannam, M D; Hanson, J; Hardwick, T; Harms, J; Harry, G M; Harry, I W; Hart, M J; Hartman, M T; Haster, C -J; Haughian, K; Heidmann, A; Heintze, M C; Heitmann, H; Hello, P; Hemming, G; Hendry, M; Heng, I S; Hennig, J; Heptonstall, A W; Heurs, M; Hild, S; Hoak, D; Hodge, K A; Hofman, D; Hollitt, S E; Holt, K; Holz, D E; Hopkins, P; Hosken, D J; Hough, J; Houston, E A; Howell, E J; Hu, Y M; Huang, S; Huerta, E A; Huet, D; Hughey, B; Husa, S; Huttner, S H; Huynh-Dinh, T; Idrisy, A; Indik, N; Ingram, D R; Inta, R; Isa, H N; Isac, J -M; Isi, M; Islas, G; Isogai, T; Iyer, B R; Izumi, K; Jacqmin, T; Jang, H; Jani, K; Jaranowski, P; Jawahar, S; Jiménez-Forteza, F; Johnson, W W; Jones, D I; Jones, R; Jonker, R J G; Ju, L; K, Haris; Kalaghatgi, C V; Kalogera, V; Kandhasamy, S; Kang, G; Kanner, J B; Karki, S; Kasprzack, M; Katsavounidis, E; Katzman, W; Kaufer, S; Kaur, T; Kawabe, K; Kawazoe, F; Kéfélian, F; Kehl, M S; Keitel, D; Kelley, D B; Kells, W; Kennedy, R; Key, J S; Khalaidovski, A; Khalili, F Y; Khan, I; Khan, S; Khan, Z; Khazanov, E A; Kijbunchoo, N; Kim, Chunglee; Kim, J; Kim, K; Kim, Nam-Gyu; Kim, Namjun; Kim, Y -M; King, E J; King, P J; Kinzel, D L; Kissel, J S; Kleybolte, L; Klimenko, S; Koehlenbeck, S M; Kokeyama, K; Koley, S; Kondrashov, V; Kontos, A; Korobko, M; Korth, W Z; Kowalska, I; Kozak, D B; Kringel, V; Królak, A; Krueger, C; Kuehn, G; Kumar, P; Kuo, L; Kutynia, A; Lackey, B D; Landry, M; Lange, J; Lantz, B; Lasky, P D; Lazzarini, A; Lazzaro, C; Leaci, P; Leavey, S; Lebigot, E O; Lee, C H; Lee, H K; Lee, H M; Lee, K; Lenon, A; Leonardi, M; Leong, J R; Leroy, N; Letendre, N; Levin, Y; Levine, B M; Li, T G F; Libson, A; Littenberg, T B; Lockerbie, N A; Logue, J; Lombardi, A L; Lord, J E; Lorenzini, M; Loriette, V; Lormand, M; Losurdo, G; Lough, J D; Lück, H; Lundgren, A P; Luo, J; Lynch, R; Ma, Y; MacDonald, T; Machenschalk, B; MacInnis, M; Macleod, D M; Magaña-Sandoval, F; Magee, R M; Mageswaran, M; Majorana, E; Maksimovic, I; Malvezzi, V; Man, N; Mandic, V; Mangano, V; Mansell, G L; Manske, M; Mantovani, M; Marchesoni, F; Marion, F; Márka, S; Márka, Z; Markosyan, A S; Maros, E; Martelli, F; Martellini, L; Martin, I W; Martin, R M; Martynov, D V; Marx, J N; Mason, K; Masserot, A; Massinger, T J; Masso-Reid, M; Mastrogiovanni, S; Matichard, F; Matone, L; Mavalvala, N; Mazumder, N; Mazzolo, G; McCarthy, R; McClelland, D E; McCormick, S; McGuire, S C; McIntyre, G; McIver, J; McManus, D J; McWilliams, S T; Meacher, D; Meadors, G D; Meidam, J; Melatos, A; Mendell, G; Mendoza-Gandara, D; Mercer, R A; Merilh, E L; Merzougui, M; Meshkov, S; Messenger, C; Messick, C; Metzdorff, R; Meyers, P M; Mezzani, F; Miao, H; Michel, C; Middleton, H; Mikhailov, E E; Milano, L; Miller, A L; Miller, J; Millhouse, M; Minenkov, Y; Ming, J; Mirshekari, S; Mishra, C; Mitra, S; Mitrofanov, V P; Mitselmakher, G; Mittleman, R; Moggi, A; Mohan, M; Mohapatra, S R P; Montani, M; Moore, B C; Moore, C J; Moraru, D; Moreno, G; Morriss, S R; Mossavi, K; Mours, B; Mow-Lowry, C M; Mueller, C L; Mueller, G; Muir, A W; Mukherjee, Arunava; Mukherjee, D; Mukherjee, S; Mukund, K N; Mullavey, A; Munch, J; Murphy, D J; Murray, P G; Mytidis, A; Nardecchia, I; Naticchioni, L; Nayak, R K; Necula, V; Nedkova, K; Nelemans, G; Neri, M; Neunzert, A; Newton, G; Nguyen, T T; Nielsen, A B; Nissanke, S; Nitz, A; Nocera, F; Nolting, D; Normandin, M E N; Nuttall, L K; Oberling, J; Ochsner, E; O'Dell, J; Oelker, E; Ogin, G H; Oh, J J; Oh, S H; Ohme, F; Oliver, M; Oppermann, P; Oram, Richard J; O'Reilly, B; O'Shaughnessy, R; Ott, C D; Ottaway, D J; Ottens, R S; Overmier, H; Owen, B J; Pai, A; Pai, S A; Palamos, J R; Palashov, O; Palomba, C; Pal-Singh, A; Pan, H; Pankow, C; Pannarale, F; Pant, B C; Paoletti, F; Paoli, A; Papa, M A; Paris, H R; Parker, W; Pascucci, D; Pasqualetti, A; Passaquieti, R; Passuello, D; Patricelli, B; Patrick, Z; Pearlstone, B L; Pedraza, M; Pedurand, R; Pekowsky, L; Pele, A; Penn, S; Pereira, R; Perreca, A; Phelps, M; Piccinni, O J; Pichot, M; Piergiovanni, F; Pierro, V; Pillant, G; Pinard, L; Pinto, I M; Pitkin, M; Pletsch, H J; Poggiani, R; Popolizio, P; Post, A; Powell, J; Prasad, J; Predoi, V; Premachandra, S S; Prestegard, T; Price, L R; Prijatelj, M; Principe, M; Privitera, S; Prodi, G A; Prokhorov, L; Puncken, O; Punturo, M; Puppo, P; Pürrer, M; Qi, H; Qin, J; Quetschke, V; Quintero, E A; Quitzow-James, R; Raab, F J; Rabeling, D S; Radkins, H; Raffai, P; Raja, S; Rakhmanov, M; Rapagnani, P; Raymond, V; Razzano, M; Re, V; Read, J; Reed, C M; Regimbau, T; Rei, L; Reid, S; Reitze, D H; Rew, H; Ricci, F; Riles, K; Robertson, N A; Robie, R; Robinet, F; Rocchi, A; Rolland, L; Rollins, J G; Roma, V J; Romano, J D; Romano, R; Romanov, G; Romie, J H; Rosińska, D; Rowan, S; Rüdiger, A; Ruggi, P; Ryan, K; Sachdev, S; Sadecki, T; Sadeghian, L; Salconi, L; Saleem, M; Salemi, F; Samajdar, A; Sammut, L; Sanchez, E J; Sandberg, V; Sandeen, B; Sanders, J R; Sassolas, B; Sathyaprakash, B S; Saulson, P R; Sauter, O E S; Savage, R L; Sawadsky, A; Schale, P; Schilling, R; Schmidt, J; Schmidt, P; Schnabel, R; Schofield, R M S; Schönbeck, A; Schreiber, E; Schuette, D; Schutz, B F; Scott, J; Scott, S M; Sellers, D; Sentenac, D; Sequino, V; Sergeev, A; Serna, G; Setyawati, Y; Sevigny, A; Shaddock, D A; Shahriar, M S; Shaltev, M; Shao, Z; Shapiro, B; Shawhan, P; Sheperd, A; Shoemaker, D H; Shoemaker, D M; Siellez, K; Siemens, X; Sieniawska, M; Sigg, D; Silva, A D; Simakov, D; Singer, A; Singer, L P; Singh, A; Singh, R; Singhal, A; Sintes, A M; Slagmolen, B J J; Smith, J R; Smith, N D; Smith, R J E; Son, E J; Sorazu, B; Sorrentino, F; Souradeep, T; Srivastava, A K; Staley, A; Steinke, M; Steinlechner, J; Steinlechner, S; Steinmeyer, D; Stephens, B C; Stiles, D; Stone, R; Strain, K A; Straniero, N; Stratta, G; Strauss, N A; Strigin, S; Sturani, R; Stuver, A L; Summerscales, T Z; Sun, L; Sutton, P J; Swinkels, B L; Szczepańczyk, M J; Tacca, M; Talukder, D; Tanner, D B; Tápai, M; Tarabrin, S P; Taracchini, A; Taylor, R; Theeg, T; Thirugnanasambandam, M P; Thomas, E G; Thomas, M; Thomas, P; Thorne, K A; Thrane, E; Tiwari, S; Tiwari, V; Tokmakov, K V; Tomlinson, C; Tonelli, M; Torres, C V; Torrie, C I; Töyrä, D; Travasso, F; Traylor, G; Trifirò, D; Tringali, M C; Trozzo, L; Tse, M; Turconi, M; Tuyenbayev, D; Ugolini, D; Unnikrishnan, C S; Urban, A L; Usman, S A; Vahlbruch, H; Vajente, G; Valdes, G; van Bakel, N; van Beuzekom, M; Brand, J F J van den; Broeck, C Van Den; Vander-Hyde, D C; van der Schaaf, L; van Heijningen, J V; van Veggel, A A; Vardaro, M; Vass, S; Vasúth, M; Vaulin, R; Vecchio, A; Vedovato, G; Veitch, J; Veitch, P J; Venkateswara, K; Verkindt, D; Vetrano, F; Viceré, A; Vinciguerra, S; Vine, D J; Vinet, J -Y; Vitale, S; Vo, T; Vocca, H; Vorvick, C; Voss, D V; Vousden, W D; Vyatchanin, S P; Wade, A R; Wade, L E; Wade, M; Walker, M; Wallace, L; Walsh, S; Wang, G; Wang, H; Wang, M; Wang, X; Wang, Y; Ward, R L; Warner, J; Was, M; Weaver, B; Wei, L -W; Weinert, M; Weinstein, A J; Weiss, R; Welborn, T; Wen, L; Wessels, P; Westphal, T; Wette, K; Whelan, J T; Whitcomb, S E; White, D J; Whiting, B F; Williams, R D; Williamson, A R; Willis, J L; Willke, B; Wimmer, M H; Winkler, W; Wipf, C C; Wittel, H; Woan, G; Worden, J; Wright, J L; Wu, G; Yablon, J; Yam, W; Yamamoto, H; Yancey, C C; Yap, M J; Yu, H; Yvert, M; zny, A Zadro; Zangrando, L; Zanolin, M; Zendri, J -P; Zevin, M; Zhang, F; Zhang, L; Zhang, M; Zhang, Y; Zhao, C; Zhou, M; Zhou, Z; Zhu, X J; Zucker, M E; Zuraw, S E; Zweizig, J; Archibald, A M; Banaszak, S; Berndsen, A; Boyles, J; Cardoso, R F; Chawla, P; Cherry, A; Dartez, L P; Day, D; Epstein, C R; Ford, A J; Flanigan, J; Garcia, A; Hessels, J W T; Hinojosa, J; Jenet, F A; Karako-Argaman, C; Kaspi, V M; Keane, E F; Kondratiev, V I; Kramer, M; Leake, S; Lorimer, D; Lunsford, G; Lynch, R S; Martinez, J G; Mata, A; McLaughlin, M A; McPhee, C A; Penucci, T; Ransom, S; Roberts, M S E; Rohr, M D W; Stairs, I H; Stovall, K; van Leeuwen, J; Walker, A N; Wells, B L

    2016-01-01

    We present an archival search for transient gravitational wave bursts in coincidence with 27 single pulse triggers from Green Bank Telescope pulsar surveys, using the LIGO, Virgo and GEO interferometer network. We also discuss a check for gravitational wave signals in coincidence with Parkes Fast Radio Bursts using similar methods. Data analyzed in these searches were collected between 2007 and 2013. Possible sources of emission of both short duration radio signals andtransient gravitational wave emission include starquakes on neutron stars, binary coalescence of neutron stars, and cosmic string cusps. While no evidence for gravitational wave emission in coincidence with these radio transients was found, the current analysis serves as a prototype for similar future searches using more sensitive second generation interferometers.

  8. Application of a simple asynchronous mechanical light chopper to multielectron coincidence spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Ito, Kenji; Suzuki, Isao H. [Photon Factory, IMSS, KEK, Oho 1-1, Tsukuba, Ibaraki 305-0801 (Japan); Penent, Francis; Lablanquie, Pascal [Universite Pierre et Marie Curie (UPMC), 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05 (France); CNRS, LCPMR(UMR 7614), 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05 (France); Hikosaka, Yasumasa; Shigemasa, Eiji [UVSOR Facility, Institute for Molecular Science, Okazaki 444-8585 (Japan); Eland, John H. D. [PTCL, Oxford University, South Parks Road, Oxford OX1 3QZ (United Kingdom)

    2009-12-15

    A simple asynchronous mechanical light chopper, based on modification of a turbo-molecular pump, has been developed to extend the interval between light pulses in single bunch operation at the Photon Factory storage ring. A pulse repetition rate of 80 kHz was achieved using a cylinder rotating at 48000 rpm, with 100 slits of 80 {mu}m width. This allows absolute timing of particles up to 12.48 {mu}s instead of the single-bunch period of 624 ns. We have applied the chopper together with a light pulse monitor to measure multielectron coincidence spectra using a magnetic bottle time-of-flight electron spectrometer. With such a system, the electron energies are determined without any ambiguity, the folding of coincidence spectra disappears and the effect of false coincidences is drastically reduced.

  9. Simulations of Lithium-Based Neutron Coincidence Counter for Gd-Loaded Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Cowles, Christian C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Kouzes, Richard T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Siciliano, Edward R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-10-01

    The Department of Energy Office of Nuclear Safeguards and Security (NA-241) is supporting the project Lithium-Based Alternative Neutron Detection Technology Coincidence Counting for Gd-loaded Fuels at Pacific Northwest National Laboratory for the development of a lithium-based neutron coincidence counter for nondestructively assaying Gd loaded nuclear fuel. This report provides results from MCNP simulations of a lithium-based coincidence counter for the possible measurement of Gd-loaded nuclear fuel. A comparison of lithium-based simulations and UNCL-II simulations with and without Gd loaded fuel is provided. A lithium-based model, referred to as PLNS3A-R1, showed strong promise for assaying Gd loaded fuel.

  10. Performance demonstration of 4πβ(LS)-γ coincidence counting system for standardization of radionuclides with complex decay scheme.

    Science.gov (United States)

    Kulkarni, D B; Anuradha, R; Joseph, Leena; Kulkarni, M S; Tomar, B S

    2016-02-01

    A standardization of (134)Cs and (131)I was carried out in order to demonstrate the performance and applicability of the 4πβ(LS)-γ coincidence counting system for standardization of radionuclides with complex decay scheme. The coincidence analyzer, capable of analyzing coincidence between beta and two gamma windows simultaneously, was developed and used for the standardization. The use of this dual coincidence analyzer has reduced the total experimental time by half. The activity concentrations obtained using the 4πβ(LS)-γ coincidence counting system, a 4πβ(PC)-γ coincidence counting system, and the CIEMAT/NIST method are in excellent agreement with each other within uncertainty limits and hence demonstrates its performance for standardization of radionuclides decaying with complex decay scheme. Hence use of this 4πβ(LS)-γ coincidence counting system can be an alternative method suitable to standardize radionuclides with complex decay scheme with acceptable precision.

  11. Angular shaping of fluorescence from synthetic opal-based photonic crystal.

    Science.gov (United States)

    Boiko, Vitalii; Dovbeshko, Galyna; Dolgov, Leonid; Kiisk, Valter; Sildos, Ilmo; Loot, Ardi; Gorelik, Vladimir

    2015-01-01

    Spectral, angular, and temporal distributions of fluorescence as well as specular reflection were investigated for silica-based artificial opals. Periodic arrangement of nanosized silica globules in the opal causes a specific dip in the defect-related fluorescence spectra and a peak in the reflectance spectrum. The spectral position of the dip coincides with the photonic stop band. The latter is dependent on the size of silica globules and the angle of observation. The spectral shape and intensity of defect-related fluorescence can be controlled by variation of detection angle. Fluorescence intensity increases up to two times at the edges of the spectral dip. Partial photobleaching of fluorescence was observed. Photonic origin of the observed effects is discussed.

  12. Boron-Coated Straw Collar for Uranium Neutron Coincidence Collar Replacement

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Jianwei [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Croft, Stephen [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McElroy, Robert Dennis [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-01-01

    The objective of this project was to design and optimize, in simulation space, an active neutron coincidence counter (or collar) using boron-coated straws (BCSs) as a non-3He replacement to the Uranium Neutron Coincidence Collar (UNCL). UNCL has been used by the International Atomic Energy Agency (IAEA) and European Atomic Energy Community (Euratom) since the 1980s to verify the 235U content in fresh light water reactor fuel assemblies for safeguards purposes. This report documents the design and optimization of the BCS collar.

  13. Revolution of S-stars and oscillation of solar and terrestrial observables: nonrandom coincidence of periods

    CERN Document Server

    Rusov, V D; Eingorn, M V

    2015-01-01

    A striking coincidence of revolution periods of S-stars orbiting a supermassive black hole at the Galactic Center of the Milky Way and oscillation periods of such solar and terrestrial observables as the sunspot number, the geomagnetic field Y-component and the global temperature is established on basis of the corresponding experimental data. Rejecting randomness of this discovered coincidence, we put forward a hypothesis that modulation of dark matter flows in the Milky Way by the S-stars is responsible for such a frequency transfer from the Galactic Center to the Solar System.

  14. Standardization of (99m)Tc by means of a software coincidence system.

    Science.gov (United States)

    Brito, A B; Koskinas, M F; Litvak, F; Toledo, F; Dias, M S

    2012-09-01

    The procedure followed by the Nuclear Metrology Laboratory, at IPEN, for the primary standardization of (99m)Tc is described. The primary standardization has been accomplished by the coincidence method. The beta channel efficiency was varied by electronic discrimination using a software coincidence counting system. Two windows were selected for the gamma channel: one at 140 keV gamma-ray and the other at 20 keV X-ray total absorption peaks. The experimental extrapolation curves were compared with Monte Carlo simulations by means of code ESQUEMA.

  15. Development of Monte Carlo code for coincidence prompt gamma-ray neutron activation analysis

    Science.gov (United States)

    Han, Xiaogang

    Prompt Gamma-Ray Neutron Activation Analysis (PGNAA) offers a non-destructive, relatively rapid on-line method for determination of elemental composition of bulk and other samples. However, PGNAA has an inherently large background. These backgrounds are primarily due to the presence of the neutron excitation source. It also includes neutron activation of the detector and the prompt gamma rays from the structure materials of PGNAA devices. These large backgrounds limit the sensitivity and accuracy of PGNAA. Since most of the prompt gamma rays from the same element are emitted in coincidence, a possible approach for further improvement is to change the traditional PGNAA measurement technique and introduce the gamma-gamma coincidence technique. It is well known that the coincidence techniques can eliminate most of the interference backgrounds and improve the signal-to-noise ratio. A new Monte Carlo code, CEARCPG has been developed at CEAR to simulate gamma-gamma coincidence spectra in PGNAA experiment. Compared to the other existing Monte Carlo code CEARPGA I and CEARPGA II, a new algorithm of sampling the prompt gamma rays produced from neutron capture reaction and neutron inelastic scattering reaction, is developed in this work. All the prompt gamma rays are taken into account by using this new algorithm. Before this work, the commonly used method is to interpolate the prompt gamma rays from the pre-calculated gamma-ray table. This technique works fine for the single spectrum. However it limits the capability to simulate the coincidence spectrum. The new algorithm samples the prompt gamma rays from the nucleus excitation scheme. The primary nuclear data library used to sample the prompt gamma rays comes from ENSDF library. Three cases are simulated and the simulated results are benchmarked with experiments. The first case is the prototype for ETI PGNAA application. This case is designed to check the capability of CEARCPG for single spectrum simulation. The second

  16. n-Tupled Coincidence Point Theorems for Probabilistic ψ-Contractions in Menger Spaces

    Directory of Open Access Journals (Sweden)

    Penumarthy Parvateesam Murthy

    2016-01-01

    Full Text Available We introduced n-tupled coincidence point for a pair of maps T:Xn→X and A:X→X in Menger space. Utilizing the properties of the pseudometric and the triangular norm, we will establish n-tupled coincidence point theorems under weak compatibility as well as n-tupled fixed point theorems for hybrid probabilistic ψ-contractions with a gauge function. Our main results do not require the conditions of continuity and monotonicity of ψ. At the end of this paper, an example is given to support our main theorem.

  17. Nine New Fluorescent Probes

    Science.gov (United States)

    Lin, Tsung-I.; Jovanovic, Misa V.; Dowben, Robert M.

    1989-06-01

    Absorption and fluorescence spectroscopic studies are reported here for nine new fluorescent probes recently synthesized in our laboratories: four pyrene derivatives with substituents of (i) 1,3-diacetoxy-6,8-dichlorosulfonyl, (ii) 1,3-dihydroxy-6,8-disodiumsulfonate, (iii) 1,3-disodiumsulfonate, and (iv) l-ethoxy-3,6,8-trisodiumsulfonate groups, and five [7-julolidino] coumarin derivatives with substituents of (v) 3-carboxylate-4-methyl, (vi) 3- methylcarboxylate, (vii) 3-acetate-4-methyl, (viii) 3-propionate-4-methyl, and (ix) 3-sulfonate-4-methyl groups. Pyrene compounds i and ii and coumarin compounds v and vi exhibit interesting absorbance and fluorescence properties: their absorption maxima are red shifted compared to the parent compound to the blue-green region, and the band width broadens considerably. All four blue-absorbing dyes fluoresce intensely in the green region, and the two pyrene compounds emit at such long wavelengths without formation of excimers. The fluorescence properties of these compounds are quite environment-sensitive: considerable spectral shifts and fluorescence intensity changes have been observed in the pH range from 3 to 10 and in a wide variety of polar and hydrophobic solvents with vastly different dielectric constants. The high extinction and fluorescence quantum yield of these probes make them ideal fluorescent labeling reagents for proteins, antibodies, nucleic acids, and cellular organelles. The pH and hydrophobicity-dependent fluorescence changes can be utilized as optical pH and/or hydrophobicity indicators for mapping environmental difference in various cellular components in a single cell. Since all nine probes absorb in the UV, but emit at different wavelengths in the visible, these two groups of compounds offer an advantage of utilizing a single monochromatic light source (e.g., a nitrogen laser) to achieve multi-wavelength detection for flow cytometry application. As a first step to explore potential application in

  18. Towards a possible solution for the coincidence problem: f(G) gravity as background

    Science.gov (United States)

    Rudra, Prabir

    2016-07-01

    In this article we address the well-known cosmic coincidence problem in the framework of the f(G) gravity. In order to achieve this, an interaction between dark energy and dark matter is considered. A set-up is designed and a constraint equation is obtained which generates the f(G) models that do not suffer from the coincidence problem. Due to the absence of a universally accepted interaction term introduced by a fundamental theory, the study is conducted over three different forms of logically chosen interaction terms. To illustrate the set-up three widely known models of f(G) gravity are taken into consideration and the problem is studied under the designed set-up. The study reveals that the popular f(G) gravity models does not approve of a satisfactory solution of the long standing coincidence problem, thus proving to be a major setback for them as successful models of universe. Finally, two non-conventional models of f(G) gravity have been proposed and studied in the framework of the designed set-up. It is seen that a complete solution of the coincidence problem is achieved for these models. The study also reveals that the 'b-interaction' term is much more preferable compared to the other interactions, due to its greater compliance with the recent observational data.

  19. Pre-coincidence brain activity predicts the perceptual outcome of streaming/bouncing motion display.

    Science.gov (United States)

    Zhao, Song; Wang, Yajie; Jia, Lina; Feng, Chengzhi; Liao, Yu; Feng, Wenfeng

    2017-08-18

    When two identical visual discs move toward each other on a two-dimensional visual display, they can be perceived as either "streaming through" or "bouncing off" each other after their coincidence. Previous studies have observed a strong bias toward the streaming percept. Additionally, the incidence of the bouncing percept in this ambiguous display could be increased by various factors, such as a brief sound at the moment of coincidence and a momentary pause of the two discs. The streaming/bouncing bistable motion phenomenon has been studied intensively since its discovery. However, little is known regarding the neural basis underling the perceptual ambiguity in the classic version of the streaming/bouncing motion display. The present study investigated the neural basis of the perception disambiguating underling the processing of the streaming/bouncing bistable motion display using event-related potential (ERP) recordings. Surprisingly, the amplitude of frontal central P2 (220-260 ms) that was elicited by the moving discs ~200 ms before the coincidence of the two discs was observed to be predictive of subsequent streaming or bouncing percept. A larger P2 amplitude was observed for streaming percept than the bouncing percept. These findings suggest that the streaming/bouncing bistable perception may have been disambiguated unconsciously ~200 ms before the coincidence of the two discs.

  20. Coincidence of Homophone Spelling Errors and Attention Problems in Schoolchildren: A Survey Study

    Science.gov (United States)

    Tsai, Li-Hui; Meng, Ling-Fu; Hung, Li-Yu; Chen, Hsin-Yu; Lu, Chiu-Ping

    2011-01-01

    This article examines the relationship between writing and attention problems and hypothesizes that homophone spelling errors coincide with attention deficits. We analyze specific types of attention deficits, which may contribute to Attention Deficits Hyperactivity Disorder (ADHD); rather than studying ADHD, however, we focus on the inattention…

  1. Coincidence and fixed point results for non-commuting maps

    Directory of Open Access Journals (Sweden)

    Abdul Latif

    2008-06-01

    Full Text Available In the setting of Banach spaces, some results on the existence of coincidence and common fixed points for single-valued and multivalued non-commuting maps with and without contractive type conditions are obtained.

  2. Coincident-Frequency Entangled Photons in a Homogenous Gravitational Field - A Thought Experiment

    CERN Document Server

    de Matos, Clovis Jacinto

    2010-01-01

    Assuming that the Principle of energy conservation holds for coincident-frequency entangled photons propagating in a homogeneous gravitational field. It is argued that in this physical context, either Quantum entanglement or the weak equivalence principle are broken by the photons.

  3. Metformin and lactic acidosis : cause or coincidence? A review of case reports

    NARCIS (Netherlands)

    Stades, AME; Heikens, JT; Erkelens, DW; Holleman, F; Hoekstra, JBL

    2004-01-01

    Objective. Metformin has been associated with the serious side-effect lactic acidosis. However, it remains unclear whether the use of metformin was a cause or a coincidence in lactic acidosis. Design. A literature search of the Index Medicus (1959-66) and of the databases Embase, Medline, Medline Ex

  4. Continuous Selection, Collectively Fixed Points and System of Coincidence Theorems in Product Topological Spaces

    Institute of Scientific and Technical Information of China (English)

    Xie Ping DING

    2006-01-01

    Some new continuous selection theorems are first proved in noncompact topological spaces.As applications, some new collectively fixed point theorems and coincidence theorems for two families of set-valued mappings defined on product space of noncompact topological spaces are obtained under very weak assumptions. These results generalize many known results in recent literature.

  5. Constructing coincident indices of economic activity for the Latin American economy

    Directory of Open Access Journals (Sweden)

    João Victor Issler

    2013-03-01

    Full Text Available This paper has three main contributions. The first is to propose an individual coincident indicator for the following Latin American countries: Argentina, Brazil, Chile, Colombia and Mexico. In order to obtain similar series to those traditionally used in business-cycle research in constructing coincident indices (output, sales, income and employment we were forced to back-cast several individual country series which were not available in a long time-series span. The second contribution is to establish a chronology of recessions for these countries, covering the period from 1980 to 2012 on a monthly basis. Based on this chronology, the countries are compared in several respects. The final contribution is to propose an aggregate coincident indicator for the Latin American economy, which weights individual-country composite indices. Finally, this indicator is compared with the coincident indicator (The Conference Board - TCB of the U.S. economy. We find that the U.S. indicator Granger-causes the Latin American indicator in statistical tests

  6. Metformin and lactic acidosis : cause or coincidence? A review of case reports

    NARCIS (Netherlands)

    Stades, AME; Heikens, JT; Erkelens, DW; Holleman, F; Hoekstra, JBL

    Objective. Metformin has been associated with the serious side-effect lactic acidosis. However, it remains unclear whether the use of metformin was a cause or a coincidence in lactic acidosis. Design. A literature search of the Index Medicus (1959-66) and of the databases Embase, Medline, Medline

  7. Multiple scattering and accidental coincidences in the J-PET detector simulated using GATE package

    CERN Document Server

    Kowalski, P; Wiślicki, W; Raczyński, L; Bednarski, T; Białas, P; Bułka, J; Czerwiński, E; Gajos, A; Gruntowski, A; Kamińska, D; Kapłon, Ł; Kochanowski, A; Korcyl, G; Kowal, J; Kozik, T; Krzemień, W; Kubicz, E; Niedźwiecki, Sz; Pałka, M; Rudy, Z; Salabura, P; Sharma, N G; Silarski, M; Słomski, A; Smyrski, J; Strzelecki, A; Wieczorek, A; Wochlik, I; Zieliński, M; Zoń, N

    2015-01-01

    Novel Positron Emission Tomography system, based on plastic scintillators, is developed by the J-PET collaboration. In order to optimize geometrical configuration of built device, advanced computer simulations are performed. Detailed study is presented of background given by accidental coincidences and multiple scattering of gamma quanta.

  8. SYSTEM OF COINCIDENCE THEOREMS IN PRODUCT TOPOLOGICAL SPACES AND APPLICATIONS (Ⅱ)

    Institute of Scientific and Technical Information of China (English)

    DING Xie-ping

    2005-01-01

    By applying coincidence theorems in part ( Ⅰ ) for two families of setvalued mappings defined on product space of noncompact FC-spaces in preceding paper, some new existence theorems for system of vector equilibrium problems, system ofinequalities and system of minimax theorems were established in FC-spaces. These results generalize some known results in recent literature.

  9. Exploring the Dynamics of Cell Processes through Simulations of Fluorescence Microscopy Experiments

    Science.gov (United States)

    Angiolini, Juan; Plachta, Nicolas; Mocskos, Esteban; Levi, Valeria

    2015-01-01

    Fluorescence correlation spectroscopy (FCS) methods are powerful tools for unveiling the dynamical organization of cells. For simple cases, such as molecules passively moving in a homogeneous media, FCS analysis yields analytical functions that can be fitted to the experimental data to recover the phenomenological rate parameters. Unfortunately, many dynamical processes in cells do not follow these simple models, and in many instances it is not possible to obtain an analytical function through a theoretical analysis of a more complex model. In such cases, experimental analysis can be combined with Monte Carlo simulations to aid in interpretation of the data. In response to this need, we developed a method called FERNET (Fluorescence Emission Recipes and Numerical routines Toolkit) based on Monte Carlo simulations and the MCell-Blender platform, which was designed to treat the reaction-diffusion problem under realistic scenarios. This method enables us to set complex geometries of the simulation space, distribute molecules among different compartments, and define interspecies reactions with selected kinetic constants, diffusion coefficients, and species brightness. We apply this method to simulate single- and multiple-point FCS, photon-counting histogram analysis, raster image correlation spectroscopy, and two-color fluorescence cross-correlation spectroscopy. We believe that this new program could be very useful for predicting and understanding the output of fluorescence microscopy experiments. PMID:26039162

  10. Stroboscopic fluorescence lifetime imaging.

    Science.gov (United States)

    Holton, Mark D; Silvestre, Oscar R; Errington, Rachel J; Smith, Paul J; Matthews, Daniel R; Rees, Paul; Summers, Huw D

    2009-03-30

    We report a fluorescence lifetime imaging technique that uses the time integrated response to a periodic optical excitation, eliminating the need for time resolution in detection. A Dirac pulse train of variable period is used to probe the frequency response of the total fluorescence per pulse leading to a frequency roll-off that is dependent on the relaxation rate of the fluorophores. The technique is validated by demonstrating wide-field, realtime, lifetime imaging of the endocytosis of inorganic quantum dots by a cancer cell line. Surface charging of the dots in the intra-cellular environment produces a switch in the fluorescence lifetime from approximately 40 ns to technique offers lifetime based imaging at video rates with standard CCD cameras and has application in probing millisecond cell dynamics and in high throughput imaging assays.

  11. Gonadoblastomas in 45,X/46,XY mosaicism: analysis of Y chromosome distribution by fluorescence in situ hybridization.

    Science.gov (United States)

    Iezzoni, J C; Von Kap-Herr, C; Golden, W L; Gaffey, M J

    1997-08-01

    Gonadoblastomas are composed of nests of neoplastic germ cells and sex cord derivatives surrounded by ovarian-type stroma. These tumors are found almost exclusively in persons with gonadal dysgenesis associated with a Y chromosome or Y chromosome fragment, and accordingly, the Y chromosome has been implicated in gonadoblastoma oncogenesis. To evaluate this association, we used two-color fluorescence in situ hybridization with chromosome-specific probes to determine the distribution of the X and Y chromosomes in the tumor nests and surrounding stromal cells in paraffin tissue sections of three gonadoblastomas in two patients with gonadal dysgenesis and 45,X/46,XY mosaicism. Statistical analysis of the data from the fluorescence in situ hybridization demonstrated that in all three gonadoblastomas, the proportion of nuclei with a Y chromosome signal was significantly higher in the tumor cells than in the nontumoral cells of the surrounding stroma (P<.001). These results suggest that Y chromosome material participates in gonadoblastoma tumorigenesis.

  12. Nanosecond fluorescence spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Leskovar, B.

    1985-03-01

    This article is a summary of a short course lecture given in conjunction with the 1984 Nuclear Science Symposium. Measuring systems for nanosecond fluorescence spectroscopy using single-photon counting techniques are presented. These involve systems based on relaxation-type spark gap light pulser and synchronously pumped mode-locked dye lasers. Furthermore, typical characteristics and optimization of operating conditions of the critical components responsible for the system time resolution are discussed. A short comparison of the most important deconvolution methods for numerical analysis of experimental data is given particularly with respect to the signal-to-noise ratio of the fluorescence signal. 22 refs., 8 figs.

  13. Fluorescence Experiments with Quinine

    Science.gov (United States)

    O'Reilly, James E.

    1975-01-01

    Describes a series of experiments which illustrate the analytical capabilities of fluorescence, and outlines two straightforward analyses involving real analyses. These experiments are suitable for an undergraduate instrumental analysis course and require approximately six to seven hours of laboratory time. (MLH)

  14. FLEX: fluorescence explorer

    NARCIS (Netherlands)

    Stoll, M.Ph.; Court, A.J.; Smorenburg, C.; Visser, H.; Crocco, L.; Heilimo, J.; Honig, A.

    1999-01-01

    FLEX is a scientifically driven space mission to provide demonstration/validation of the instrumentation and technique for measuring the natural fluorescence of vegetation in the Fraunhofer lines. The payload consists of high spectral resolution (0.1-0.3 nm) CCD imaging grating spectrometer with two

  15. The spallation in reverse kinematics: what for a coincidence measurement?; La spallation en cinematique inverse: pourquoi faire une mesure en coincidence?

    Energy Technology Data Exchange (ETDEWEB)

    Ducret, J.E

    2006-07-15

    The Spaladin installation has been designed to study spallation reactions in reverse kinematics. Furthermore, the heavy and light fragments are detected by coincidence which allows us to get an instantaneous picture of the reaction at a level of accuracy better than that obtained through inclusive measurement. The first part is dedicated to the theoretical description of the different mechanisms involved in the spallation reactions. In the second part we describe the Spaladin installation and report some results on the reaction: Fe{sup 56} + p at an energy of 1 GeV/nucleon. In the third part we expose the performance of the installation through its simulation with the Geant-IV model. We present a study about the sensitivity of the Spaladin installation to theoretical predictions. The fourth part is dedicated to the future experiments that will be performed with the Spaladin installation. (A.C.)

  16. Safeguards Technology Factsheet 3He-free Neutron Coincidence Counter

    Energy Technology Data Exchange (ETDEWEB)

    Henzlova, Daniela [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Menlove, Howard Olsen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-04-21

    A full scale thermal neutron coincidence counter (High Level Neutron Counter – Boron: HLNB) based on 3He alternative detection technology was designed and built at LANL and field tested at Plutonium Conversion Development Facility (PCDF) of Japan Atomic Energy Agency (JAEA) during FY15. HLNB is based on boron-lined proportional plates that replace the traditional 3He proportional tubes and was designed as a direct alternative to 3He-based High Level Neutron Coincidence Counter (HLNC-II). During the JAEA field trial the HLNB demonstrated comparable performance to HLNC-II, which represents a key development in the area of 3He alternative technologies and provides a complete demonstration of the technology for nuclear safeguards applications including high mass MOX samples.

  17. Standardization of 18F by Digital beta(LS)-gamma Coincidence Counting

    CERN Document Server

    D., Rodrigues; P., Cassette; P., Arenillas; E., Capoulat M; G., Ceruti; E, García-Toraño

    2010-01-01

    The nuclide 18F disintegrates to 18O by beta+ emission (96.86%) and electron capture (3.14%) with a half-life of 1.8288 h. It is widely used in nuclear medicine for positron emission tomography (PET). Because of its short half-life this nuclide requires the development of fast measuring methods to be standardized. The combination of LSC methods with digital techniques proves to be a good alternative to get low uncertainties for this, and other, short lived nuclides. A radioactive solution of 18F has been standardized by coincidence counting with a LSC, using the logical sum of double coincidences in a TDCR array and a NaI scintillation detector. The results show good consistency with other techniques like 4Pi gamma and LSC.

  18. Coincidence system for standardization of radionuclides using a 4pi plastic scintillator detector.

    Science.gov (United States)

    Baccarelli, Aída M; Dias, Mauro S; Koskinas, Marina F

    2003-02-01

    A coincidence system using a plastic scintillator detector in 4pi geometry has been developed and applied for the standardization of radionuclides. The scintillator shape and dimensions have been optimized for maximum charge particle detection efficiency, while keeping background low and a nearly constant gamma-ray efficiency for different points from the radioactive source. The gamma-ray events were measured with a NaI(Tl) scintillation counter. The electronic system for processing pulses consisted of logic gates and delay modules feeding a time-to-amplitude converter with output to a multichannel analyzer. The alpha detection efficiency measured with 241Am was around 95% and the beta detection efficiency for 60Co was around 67%. Activity measurements of 241Am and 60Co were performed and the results showed good agreement when compared with a conventional coincidence system employing a 4pi proportional counter.

  19. Coincidence system for standardization of radionuclides using a 4 pi plastic scintillator detector

    CERN Document Server

    Baccarelli, A M; Koskinas, M F

    2003-01-01

    A coincidence system using a plastic scintillator detector in 4 pi geometry has been developed and applied for the standardization of radionuclides. The scintillator shape and dimensions have been optimized for maximum charge particle detection efficiency, while keeping background low and a nearly constant gamma-ray efficiency for different points from the radioactive source. The gamma-ray events were measured with a NaI(Tl) scintillation counter. The electronic system for processing pulses consisted of logic gates and delay modules feeding a time-to-amplitude converter with output to a multichannel analyzer. The alpha detection efficiency measured with sup 2 sup 4 sup 1 Am was around 95% and the beta detection efficiency for sup 6 sup 0 Co was around 67%. Activity measurements of sup 2 sup 4 sup 1 Am and sup 6 sup 0 Co were performed and the results showed good agreement when compared with a conventional coincidence system employing a 4 pi proportional counter.

  20. Precise measurement and calculation of coincidence summing corrections for point and linear sources.

    Science.gov (United States)

    Sima, Octavian; Arnold, Dirk

    2012-09-01

    Point sources of (60)Co, (133)Ba, (134)Cs and (152)Eu, calibrated at Physikalisch-Technische Bundesanstalt were measured in 13 positions on the axis of a 50% relative efficiency p-type detector. The peak and total efficiencies were calibrated using single photon emitting nuclides. Precise experimental values of the coincidence summing corrections were evaluated in each geometry. Synthetic linear source data, as well as the corresponding peak and total efficiency curves, were prepared using the dependence of the count rates on the position of the emitting point. The coincidence summing corrections for the linear sources were computed, analyzed with respect to different approximations and compared with simulations carried out with GESPECOR. Copyright © 2012 Elsevier Ltd. All rights reserved.

  1. Coincidence in the two-photon spectra of Li and Li2 at 735 nm

    Science.gov (United States)

    DeGraffenreid, W.; Sansonetti, Craig J.

    2005-02-01

    A coincidence between the 22S1/2-32S1/2 two-photon transition in the atomic spectrum of 6Li and the X 1Σ+g→ E 1Σ+g two-photon ro-vibrational series of 7Li2 was observed near 735 nm in a heat pipe oven using a tunable laser and thermionic diode detection scheme. The molecular transition obscures one component of the 6Li atomic transition. Selective detection of the atomic transition was obtained by adding an intensity-modulated laser that drives atoms from the 3S to 16P state. The coincident molecular transition and four nearby molecular lines were identified using previously determined Dunham coefficients.

  2. LINEAR BUNDLES WITHIN THE FRAMEWORK OF COINCIDENCE OF CIRCLE AND ELLIPSE

    Directory of Open Access Journals (Sweden)

    Polezhaev Yuriy Olegovich

    2012-10-01

    Full Text Available Compositions represented by geometrical graphic models of circular and elliptical shapes enjoy wide application in architectural and interior design. The research of variations of coincidences of circles and ellipses is a relevant subject of exploration. In the paper, the authors analyze some of the multiplicity of coincidences, and an example of their practical implementation (a church dome model. The section of an object is "amalgamated" into the architectural concept of the structure, the relief and theological ideas. Geometric interlinks, compositions and figurations of interconnected diameters, circular and elliptical arcs, their tangency, incidences and interspaces have always been of interest to researchers; they have triggered the search for harmonious and rational solutions in civil engineering and architecture. Advancements in theoretical geometrography and its software applications facilitate new solutions.

  3. Coincident site lattice-matched growth of semiconductors on substrates using compliant buffer layers

    Science.gov (United States)

    Norman, Andrew

    2016-08-23

    A method of producing semiconductor materials and devices that incorporate the semiconductor materials are provided. In particular, a method is provided of producing a semiconductor material, such as a III-V semiconductor, on a silicon substrate using a compliant buffer layer, and devices such as photovoltaic cells that incorporate the semiconductor materials. The compliant buffer material and semiconductor materials may be deposited using coincident site lattice-matching epitaxy, resulting in a close degree of lattice matching between the substrate material and deposited material for a wide variety of material compositions. The coincident site lattice matching epitaxial process, as well as the use of a ductile buffer material, reduce the internal stresses and associated crystal defects within the deposited semiconductor materials fabricated using the disclosed method. As a result, the semiconductor devices provided herein possess enhanced performance characteristics due to a relatively low density of crystal defects.

  4. Non-coincident inter-instrument comparisons of ozone measurements using quasi-conservative coordinates

    Directory of Open Access Journals (Sweden)

    L. R. Lait

    2004-08-01

    Full Text Available Ozone measurements from ozonesondes, AROTAL, DIAL, and POAM III instruments during the SOLVE-2/VINTERSOL period are composited in a time-varying, flow-following quasi-conservative (PV-θ coordinate space; the resulting composites from each instrument are mapped onto the other instruments' locations and times. The mapped data are then used to intercompare data from the different instruments. Overall, the four ozone data sets are found to be in good agreement. AROTAL shows somewhat lower values below 16 km, and DIAL has a positive bias at the upper limits of its altitude range. These intercomparisons are consistent with those obtained from more conventional near-coincident profiles, where available. Although the PV-θ mapping technique entails larger uncertainties of individual profile differences compared to direct near-coincident comparisons, the ability to include much larger numbers of comparisons can make this technique advantageous.

  5. Planned search for LIGO-GBM coincidence in the first advanced LIGO data run

    CERN Document Server

    Camp, Jordan; Briggs, Michael; Christensen, Nelson; Connaughton, Valerie; Singer, Leo; Shawhan, Peter; Veitch, John

    2015-01-01

    In the fall of 2015 the first scientific observing run (O1) of the advanced LIGO detectors will be conducted. Based on the recent commissioning progress at the LIGO Hanford and Livingston sites, the gravitational wave detector range for a neutron star binary inspiral is expected to be of order 60 Mpc. We describe here our planning for an O1 search for coincidence between a LIGO gravitational wave detection and a gamma-ray signal from the Fermi Gamma-ray Burst Monitor. Such a coincidence would constitute measurement of an electromagnetic counterpart to a gravitational wave signal, with significant corresponding scientific benefits, including revealing the central engine powering the gamma-ray burst, enhanced confidence in the event as a genuine astrophysical detection, and a determination of the relative speed of the photon and graviton.

  6. Studies of weak capture-gamma-ray resonances via coincidence techniques

    CERN Document Server

    Rowland, C; Champagne, A E; Dummer, A K; Fitzgerald, R; Harley, E C T; Mosher, J; Runkle, R

    2002-01-01

    A method for measuring weak capture-gamma-ray resonances via gamma gamma-coincidence counting techniques is described. The coincidence apparatus consisted of a large-volume germanium detector and an annular NaI(Tl) crystal. The setup was tested by measuring the weak E sub R =227 keV resonance in sup 2 sup 6 Mg(p,gamma) sup 2 sup 7 Al. Absolute germanium and NaI(Tl) counting efficiencies for a range of gamma-ray energies and for different detector-target geometries are presented. Studies of the gamma-ray background in our spectra are described. Compared to previous work, our method improves the detection sensitivity for weak capture-gamma-ray resonances by a factor of approx 100. The usefulness of the present technique for investigations of interest to nuclear astrophysics is discussed.

  7. Angular distribution measurements in particle-γ coincidences using SONIC and HORUS

    Energy Technology Data Exchange (ETDEWEB)

    Wilhelmy, Julius; Derya, Vera; Hennig, Andreas; Pickstone, Simon G.; Spieker, Mark; Zilges, Andreas [Institute for Nuclear Physics, University of Cologne (Germany)

    2014-07-01

    The combined setup SONIC and HORUS consists of the γ-ray spectrometer HORUS with 14 HPGe detectors and the recently commissioned particle spectrometer SONIC with up to 8 ΔE-E silicon detectors. This setup is used to measure the ejectile of a nuclear reaction (p, d, t, or α) in coincidence with the deexciting γ rays emitted by the recoil nucleus. By requiring a certain ejectile energy (e.g. the excitation of a level), a very clean γ spectrum is obtained, in which only physically related events remain. Measuring the angular correlations between the coincident ejectiles and γ-rays allows spin assignments to excited nuclear levels by comparison to theoretical particle-γ angular correlations. An overview of the experimental setup is given, and preliminary p-γ angular correlations measured in a recent {sup 92}Mo(p,p'γ) experiment are shown.

  8. Multiple ionization of rare gases in coincidence with X-ray emission

    Energy Technology Data Exchange (ETDEWEB)

    Justiniano, E.; Konrad, J.; Schuch, R.

    1989-04-01

    We present results of a multicoincident experiment where the multiple ionization of selected rare gases after collisions with 115 MeV S/sup Q+/ ions (Q = 13, 15, 16) was studied. In this work we have measured the charge state of the collisionally ionized target atom in simultaneous coincidence with the final charge state of the projectile ion and with a projectile K X-ray. For events proceeding through single electron capture, the coincidence conditions allowed us to distinguish events where capture is allowed to populate the projectile K shell, from whose where capture populates only higher excited states in the projectile. Changes in the degree of multiple ionization of the ionized target atoms were observed in one case with respect to the other. (orig.).

  9. Detection of coincident radiations in a single transducer by pulse shape analysis

    Science.gov (United States)

    Warburton, William K [Menlo Park, CA

    2008-03-11

    Pulse shape analysis determines if two radiations are in coincidence. A transducer is provided that, when it absorbs the first radiation produces an output pulse that is characterized by a shorter time constant and whose area is nominally proportional to the energy of the absorbed first radiation and, when it absorbs the second radiation produces an output pulse that is characterized by a longer time constant and whose area is nominally proportional to the energy of the absorbed second radiation. When radiation is absorbed, the output pulse is detected and two integrals are formed, the first over a time period representative of the first time constant and the second over a time period representative of the second time constant. The values of the two integrals are examined to determine whether the first radiation, the second radiation, or both were absorbed in the transducer, the latter condition defining a coincident event.

  10. Coincidence and coherent data analysis methods for gravitational wave bursts in a network of interferometric detectors

    CERN Document Server

    Arnaud, N; Bizouard, M A; Brisson, V; Cavalier, F; Davier, M; Hello, P; Kreckelberg, S; Porter, E K; Arnaud, Nicolas; Barsuglia, Matteo; Bizouard, Marie-Anne; Brisson, Violette; Cavalier, Fabien; Davier, Michel; Hello, Patrice; Kreckelberg, Stephane; Porter, Edward K.

    2003-01-01

    Network data analysis methods are the only way to properly separate real gravitational wave (GW) transient events from detector noise. They can be divided into two generic classes: the coincidence method and the coherent analysis. The former uses lists of selected events provided by each interferometer belonging to the network and tries to correlate them in time to identify a physical signal. Instead of this binary treatment of detector outputs (signal present or absent), the latter method involves first the merging of the interferometer data and looks for a common pattern, consistent with an assumed GW waveform and a given source location in the sky. The thresholds are only applied later, to validate or not the hypothesis made. As coherent algorithms use a more complete information than coincidence methods, they are expected to provide better detection performances, but at a higher computational cost. An efficient filter must yield a good compromise between a low false alarm rate (hence triggering on data at...

  11. Coincidence spectroscopy of high-lying Rydberg states produced in strong laser fields

    Science.gov (United States)

    Larimian, Seyedreza; Erattupuzha, Sonia; Lemell, Christoph; Yoshida, Shuhei; Nagele, Stefan; Maurer, Raffael; Baltuška, Andrius; Burgdörfer, Joachim; Kitzler, Markus; Xie, Xinhua

    2016-09-01

    We demonstrate the detection of high-lying Rydberg states produced in strong laser fields with coincidence spectroscopy. Electron emission after the interaction of strong laser pulses with atoms and molecules is measured together with the parent ions in coincidence measurements. These electrons originate from high-lying Rydberg states with quantum numbers from n ˜20 up to n ≲120 formed by frustrated field ionization. Ionization rates are retrieved from the measured ionization signal of these Rydberg states. Simulations show that both tunneling ionization by a weak dc field and photoionization by blackbody radiation contribute to delayed electron emission on the nano- to microsecond scale. Furthermore, the dependence of the Rydberg-state production on the ellipticity of the driving laser field indicates that such high-lying Rydberg states are populated through electron recapture. The present experiment provides detailed quantitative information on Rydberg production in strong-field interaction.

  12. Disentangling Multichannel Photodissociation Dynamics in Acetone by Time-Resolved Photoelectron-Photoion Coincidence Spectroscopy.

    Science.gov (United States)

    Maierhofer, Paul; Bainschab, Markus; Thaler, Bernhard; Heim, Pascal; Ernst, Wolfgang E; Koch, Markus

    2016-08-18

    For the investigation of photoinduced dynamics in molecules with time-resolved pump-probe photoionization spectroscopy, it is essential to obtain unequivocal information about the fragmentation behavior induced by the laser pulses. We present time-resolved photoelectron-photoion coincidence (PEPICO) experiments to investigate the excited-state dynamics of isolated acetone molecules triggered by two-photon (269 nm) excitation. In the complex situation of different relaxation pathways, we unambiguously identify three distinct pump-probe ionization channels. The high selectivity of PEPICO detection allows us to observe the fragmentation behavior and to follow the time evolution of each channel separately. For channels leading to fragment ions, we quantitatively obtain the fragment-to-parent branching ratio and are able to determine experimentally whether dissociation occurs in the neutral molecule or in the parent ion. These results highlight the importance of coincidence detection for the interpretation of time-resolved photochemical relaxation and dissociation studies if multiple pathways are present.

  13. High-level neutron coincidence counter (HLNCC): users' manual

    Energy Technology Data Exchange (ETDEWEB)

    Krick, M.S.; Menlove, H.O.

    1979-06-01

    This manual describes the portable High-Level Neutron Coincidence Counter (HLNCC) developed at the Los Alamos Scientific Laboratory (LASL) for the assay of plutonium, particularly by inspectors of the International Atomic Energy Agency (IAEA). The counter is designed for the measurement of the effective /sup 240/Pu mass in plutonium samples which may have a high plutonium content. The following topics are discussed: principle of operation, description of the system, operating procedures, and applications.

  14. Detection of scintillation light in coincidence with ionizing tracks in a liquid argon time projection chamber

    CERN Document Server

    Cennini, P; Rubbia, Carlo; Sergiampietri, F; Bueno, A G; Campanelli, M; Goudsmit, P; Rubbia, André; Periale, L; Suzuki, S; Chen, C; Chen, Y; He, K; Huang, X; Li, Z; Lu, F; Ma, J; Xu, G; Xu, Z; Zhang, C; Zhang, Q; Zheng, S; Cavanna, F; Mazza, D; Piano Mortari, G; Petrera, S; Rossi, C; Mannocchi, G; Picchi, P; Arneodo, F; De Mitri, I; Palamara, O; Cavalli, D; Ferrari, A; Sala, P R; Borio di Tigliole, A A; Cesana, A; Terrani, M; Zavattari, C; Baibusinov, S; Bettini, A; Carpanese, C; Centro, Sandro; Favaretto, D; Pascoli, D; Pepato, Adriano; Pietropaolo, F; Ventura, Sandro; Benetti, P; Calligarich, E; Campo, S; Coco, S; Dolfini, R; Ghedi, B; Gigli-Berzolari, A; Mauri, F; Mazzone, L; Montanari, C; Piazzoli, A; Rappoldi, A; Raselli, G L; Rebuzzi, D; Rossella, M; Scannicchio, D A; Torre, P; Vignoli, C; Cline, D; Otwinowski, S; Wang, H; Woo, J

    1999-01-01

    A system to detect light from liquid argon scintillation has been implemented in a small, ICARUS-like, liquid argon time projection chamber. The system, which uses a VUV-sensitive photomultiplier to collect the light, has recorded many ionizing tracks from cosmic-rays in coincidence with scintillation signals. Our measurements demonstrate that scintillation light detection can provide an effective method for absolute time measurement of events and eventually a useful trigger signal. (19 refs).

  15. Determination of U-chain concentration in NaI(Tl) scintillator by delayed coincidence method

    CERN Document Server

    Umehara, S; Koori, N; Kudomi, N; Kume, K; Kuramoto, H; Nakayama, S; Shimojo, T; Takahisa, K; Tsubakida, R; Tsujimoto, Y; Yoshida, S

    2002-01-01

    We have accurately determined U-chain concentration in a detector by means of the beta-alpha delayed coincidence method. This method can measure the radioactivity of the order of 10 sup - sup 7 Bq/kg. It corresponds to the concentration of the order of 0.01 ppt under the assumption that the U-chain is in the secular radioactive equilibrium, by a signal-to-noise ratio of one to one.

  16. Coincidence of Incomplete Pentalogy of Cantrell and Meningomyelocele in a Dizygotic Twin Pregnancy

    Science.gov (United States)

    Timur, Hakan; Tokmak, Aytekin; Bayram, Hatice; Şükran Çakar, Esra; Danışman, Nuri

    2015-01-01

    Pentalogy of Cantrell is an extremely rare and lethal syndrome. Ectopia cordis is frequently found in fetuses with POC but not required for incomplete forms. Likewise, meningomyelocele is a relatively uncommon neural tube defect affecting central nervous system and associated with neurological problems. Herein, we presented a woman with dizygotic twin pregnancy having coincidence of incomplete POC and MMC in each individual fetus, which has never been reported previously. PMID:26421202

  17. Coincidence of Incomplete Pentalogy of Cantrell and Meningomyelocele in a Dizygotic Twin Pregnancy

    Directory of Open Access Journals (Sweden)

    Hakan Timur

    2015-01-01

    Full Text Available Pentalogy of Cantrell is an extremely rare and lethal syndrome. Ectopia cordis is frequently found in fetuses with POC but not required for incomplete forms. Likewise, meningomyelocele is a relatively uncommon neural tube defect affecting central nervous system and associated with neurological problems. Herein, we presented a woman with dizygotic twin pregnancy having coincidence of incomplete POC and MMC in each individual fetus, which has never been reported previously.

  18. The DOE Automated Radioxenon Sampler-Analyzer (ARSA) Beta-Gamma Coincidence Spectrometer Data Analyzer

    Science.gov (United States)

    2000-09-01

    detected using the counting system given the daily fluctuations in Radon gas interference, the background counts, the memory effect of previous...THE DOE AUTOMATED RADIOXENON SAMPLER-ANALYZER (ARSA) BETA-GAMMA COINCIDENCE SPECTROMETER DATA ANALYZER T.R. Heimbigner, T.W. Bowyer, J.I...1830 ABSTRACT The Automated Radioxenon Sampler/Analyzer (ARSA) developed at the Pacific Northwest National Laboratory for the Comprehensive

  19. The Anthropic Principle and numerical coincidences involving the cosmological, gravitational and fine structure constants

    CERN Document Server

    Eaves, Laurence

    2014-01-01

    Christian Beck has proposed a set of Shannon-Khinchin axioms to derive a formula for the cosmological constant, {\\Lambda}. We discuss this result in relation to numerical coincidences involving the measured values of {\\Lambda} and the gravitational and fine structure constants, G and {\\alpha}. The empirical formulae that inter-relate the three constants suggest that the measured values of G and {\\Lambda} are consistent with the apparent anthropic fine-tuning of {\\alpha}.

  20. Two Coincidence Detectors for Spike Timing-Dependent Plasticity in Somatosensory Cortex

    OpenAIRE

    2006-01-01

    Many cortical synapses exhibit spike timing-dependent plasticity (STDP) in which the precise timing of presynaptic and postsynaptic spikes induces synaptic strengthening [long-term potentiation (LTP)] or weakening [long-term depression (LTD)]. Standard models posit a single, postsynaptic, NMDA receptor-based coincidence detector for LTP and LTD components of STDP. We show instead that STDP at layer 4 to layer 2/3 synapses in somatosensory (S1) cortex involves separate calcium sources and coin...

  1. Surgical guidance system using hand-held probe with accompanying positron coincidence detector

    Energy Technology Data Exchange (ETDEWEB)

    Majewski, Stanislaw; Weisenberger, Andrew G.

    2017-10-10

    A surgical guidance system offering different levels of imaging capability while maintaining the same hand-held convenient small size of light-weight intra-operative probes. The surgical guidance system includes a second detector, typically an imager, located behind the area of surgical interest to form a coincidence guidance system with the hand-held probe. This approach is focused on the detection of positron emitting biomarkers with gamma rays accompanying positron emissions from the radiolabeled nuclei.

  2. The efficiency variation method for 4pibeta-gamma coincidence counting by ink-jet printing.

    Science.gov (United States)

    Sato, Y; Yamada, T; Hata, T; Moriyama, K; Yunoki, A; Hino, Y

    2008-01-01

    In order to vary the counting efficiencies in the 4pibeta-gamma coincidence extrapolation technique, a radioactive source was coated directly with varying amounts of an electrical conducting pigment using an ink-jet printer. This method can be used to efficiently prepare the multiple sources needed to generate efficiency extrapolation curves, and was successfully applied to the standardization of a (54)Mn source.

  3. Tolerance to Sound Intensity of Binaural Coincidence Detection in the Nucleus Laminaris of the Owl

    OpenAIRE

    Peña, Jose Luis; Viete, Svenja; Albeck, Yehuda; Konishi, Masakazu

    1996-01-01

    Neurons of the owl's nucleus laminaris serve as coincidence detectors for measurement of interaural time difference. The discharge rate of nucleus laminaris neurons for both monaural and binaural stimulation increased with sound intensity until they reached an asymptote. Intense sounds affected neither the ratio between binaural and monaural responses nor the interaural time difference for which nucleus laminaris neurons were selective. Theoretical analysis showed that high afferent discharge...

  4. The matching theorems and coincidence theorems for generalized R-KKM mapping in topological spaces

    Science.gov (United States)

    Huang, Jianhua

    2005-12-01

    In this paper we present some new matching theorems with open cover and closed cover by using the generalized R-KKM theorems [L. Deng, X. Xia, Generalized R-KKM theorem in topological space and their applications, J. Math. Anal. Appl. 285 (2003) 679-690] in the topological spaces with property (H). As applications, some coincidence theorems are established in topological spaces. Our results extend and generalize some known results.

  5. SYSTEM OF COINCIDENCE THEOREMS IN PRODUCT TOPOLOGICAL SPACES AND APPLICATIONS (Ⅰ)

    Institute of Scientific and Technical Information of China (English)

    DING Xie-ping

    2005-01-01

    A new notion of finite continuous topological space (in short, FC-space)with out convexity structure was introduced. A new continuous selection theorem was established in FC-spaces. By applying the continuous selection theorem, some new coincidence theorems for two families of set-valued mappings defined on product space of noncompact FC-spaces are proved under much weak assumptions. These results generalize many known results in recent literature. Some applications will be given in a follow-up paper.

  6. Functional brain abnormalities localized in 55 chronic tinnitus patients: fusion of SPECT coincidence imaging and MRI.

    Science.gov (United States)

    Farhadi, Mohammad; Mahmoudian, Saeid; Saddadi, Fariba; Karimian, Ali Reza; Mirzaee, Mohammad; Ahmadizadeh, Majid; Ghasemikian, Khosro; Gholami, Saeid; Ghoreyshi, Esmaeel; Beyty, Saeid; Shamshiri, Ahmadreza; Madani, Sedighe; Bakaev, Valery; Moradkhani, Seddighe; Raeisali, Gholamreza

    2010-04-01

    Tinnitus is often defined as the perception of sounds or noise in the absence of any external auditory stimuli. The pathophysiology of subjective idiopathic tinnitus remains unclear. The aim of this study was to investigate the functional brain activities and possible involved cerebral areas in subjective idiopathic tinnitus patients by means of single photon emission computerized tomography (SPECT) coincidence imaging, which was fused with magnetic resonance imaging (MRI). In this cross-sectional study, 56 patients (1 subject excluded) with subjective tinnitus and 8 healthy controls were enrolled. After intravenous injection of 5 mCi F18-FDG (fluorodeoxyglucose), all subjects underwent a brain SPECT coincidence scan, which was then superimposed on their MRIs. In the eight regions of interest (middle temporal, inferotemporal, medial temporal, lateral temporal, temporoparietal, frontal, frontoparietal, and parietal areas), the more pronounced values were represented in medial temporal, inferotemporal, and temporoparietal areas, which showed more important proportion of associative auditory cortices in functional attributions of tinnitus than primary auditory cortex. Brain coincidence SPECT scan, when fused on MRI is a valuable technique in the assessment of patients with tinnitus and could show the significant role of different regions of central nervous system in functional attributions of tinnitus.

  7. A near-infrared SETI experiment: probability distribution of false coincidences

    Science.gov (United States)

    Maire, Jérôme; Wright, Shelley A.; Werthimer, Dan; Treffers, Richard R.; Marcy, Geoffrey W.; Stone, Remington P. S.; Drake, Frank; Siemion, Andrew

    2014-07-01

    A Search for Extraterrestrial Life (SETI), based on the possibility of interstellar communication via laser signals, is being designed to extend the search into the near-infrared spectral region (Wright et al, this conference). The dedicated near-infrared (900 to 1700 nm) instrument takes advantage of a new generation of avalanche photodiodes (APD), based on internal discrete amplification. These discrete APD (DAPD) detectors have a high speed response (laser light pulse detection in our experiment. These criteria are defined to optimize the trade between high detection efficiency and low false positive coincident signals, which can be produced by detector dark noise, background light, cosmic rays, and astronomical sources. We investigate experimentally how false coincidence rates depend on the number of detectors in parallel, and on the signal pulse height and width. We also look into the corresponding threshold to each of the signals to optimize the sensitivity while also reducing the false coincidence rates. Lastly, we discuss the analytical solution used to predict the probability of laser pulse detection with multiple detectors.

  8. Towards a possible solution for the coincidence problem: f(G) gravity as background

    CERN Document Server

    Rudra, Prabir

    2014-01-01

    In this article we address the well-known cosmic coincidence problem in the framework of the f(G) gravity. In order to achieve this, an interaction between dark energy and dark matter is considered. A set-up is designed and a constraint equation is obtained which generates the f(G) models that do not suffer from the coincidence problem. Due to the absence of a universally accepted interaction term introduced by a fundamental theory, the study is conducted over three different forms of logically chosen interaction terms. To illustrate the set-up three widely known models of f(G) gravity are taken into consideration and the problem is studied under the designed set-up. The study reveals that the popular f(G) gravity models does not approve of a satisfactory solution of the long standing coincidence problem, thus proving to be a major setback for them as successful models of universe. Finally, two non-conventional models of f(G) gravity have been proposed and studied in the framework of the designed set-up. It i...

  9. Frequencies of mutagen-induced coincident mitotic recombination at unlinked loci in Saccharomyces cerevisiae

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, Kathryn M. [Department of Biology, College of the Holy Cross, One College Street, Worcester, MA 01610-2395 (United States); Hoffmann, George R. [Department of Biology, College of the Holy Cross, One College Street, Worcester, MA 01610-2395 (United States)]. E-mail: ghoffmann@holycross.edu

    2007-03-01

    Frequencies of coincident genetic events were measured in strain D7 of Saccharomyces cerevisiae. This diploid strain permits the detection of mitotic gene conversion involving the trp5-12 and trp5-27 alleles, mitotic crossing-over and gene conversion leading to the expression of the ade2-40 and ade2-119 alleles as red and pink colonies, and reversion of the ilv1-92 allele. The three genes are on different chromosomes, and one might expect that coincident (simultaneous) genetic alterations at two loci would occur at frequencies predicted by those of the single alterations acting as independent events. Contrary to this expectation, we observed that ade2 recombinants induced by bleomycin, {beta}-propiolactone, and ultraviolet radiation occur more frequently among trp5 convertants than among total colonies. This excess among trp5 recombinants indicates that double recombinants are more common than expected for independent events. No similar enrichment was found among Ilv{sup +} revertants. The possibility of an artifact in which haploid yeasts that mimic mitotic recombinants are generated by a low frequency of cryptic meiosis has been excluded. Several hypotheses that can explain the elevated incidence of coincident mitotic recombination have been evaluated, but the cause remains uncertain. Most evidence suggests that the excess is ascribable to a subset of the population being in a recombination-prone state.

  10. Diversification of C(4) grasses (Poaceae) does not coincide with their ecological dominance.

    Science.gov (United States)

    Bouchenak-Khelladi, Yanis; Slingsby, Jasper A; Verboom, G Anthony; Bond, William J

    2014-02-01

    The radiation of a lineage and its rise to ecological dominance are distinct phenomena and driven by different processes. For example, paleoecological data has been used to show that the Cretaceous angiosperm radiation did not coincide with their rise to dominance. Using a phylogenetic approach, we here explored the evolution of C4 grasses and evaluated whether the diversification of this group and its rise to ecological dominance in the late Miocene were decoupled. We assembled a matrix including 675 grass species of the PACMAD clade and 2784 characters (ITS and ndhF) to run a molecular dating analysis using three fossils as reference calibrations. We coded species as C3 vs. C4 and reconstructed ancestral states under maximum likelihood. We used the program BiSSE to test whether rates of diversification are correlated with photosynthetic pathway and whether the radiation of C4 lineages preceded or coincided with their rise to ecological dominance from ∼10 Ma. C4 grass lineages first originated around 35 Ma at the time of the Eocene-Oligocene transition. Accelerated diversification of C4 lineages did not coincide with their rise to ecological dominance. C4-dominated grasslands have expanded only since the Late Miocene and Pliocene. The initial diversification of their biotic elements can be tracked back as far as the Eocene-Oligocene transition. We suggest that shifts in taxonomic diversification and ecological dominance were stimulated by different factors, as in the case of the early angiosperms in the Cretaceous.

  11. A new double imaging velocity focusing coincidence experiment: i{sup 2}PEPICO

    Energy Technology Data Exchange (ETDEWEB)

    Bodi, Andras; Hemberger, Patrick; Gerber, Thomas [Paul Scherrer Institut, Villigen 5232 (Switzerland); Sztaray, Balint [Department of Chemistry, University of the Pacific, Stockton, California 95211 (United States)

    2012-08-15

    The vacuum ultraviolet (VUV) beamline of the Swiss Light Source has been upgraded after two years of operation. A new, turntable-type monochromator was constructed at the Paul Scherrer Institut, which allows for fast yaw-alignment as well as quick grating change and exchange. In addition to the original imaging photoelectron photoion coincidence endstation (iPEPICO), a second, complementary double imaging setup (i{sup 2}PEPICO) has been built. Volatile samples can be introduced at room temperature or in a molecular beam, a pyrolysis source allows for radical production, and non-volatile solids can be evaporated in a heated cell. Monochromatic VUV radiation ionizes the sample and both photoelectrons and photoions are velocity map imaged onto two fast position sensitive detectors and detected in delayed coincidence. High intensity synchrotron radiation leads to ionization rates above 10{sup 5} s{sup -1}. New data acquisition and processing approaches are discussed for recording coincidence processes at high rates. The setup is capable of resolving pulsed molecular beam profiles and the synchrotron time structure temporally. The latter is shown by photoelectron autocorrelation, which displays both the 1.04 MHz ring clock frequency as well as resolving the micro-pulses with a separation of 2 ns. Kinetic energy release analysis on the dissociative photoionization of CF{sub 4} indicates a dissociation mechanism change in the Franck-Condon allowed energy range of the first ion state.

  12. Development of a TES-Based Anti-Coincidence Detector for Future X-Ray Observations

    Science.gov (United States)

    Bailey, Catherine N.; Adams, J. S.; Bandler, S. R.; Eckart, M. E.; Ewin, A. J.; Finkbeiner, F. M.; Kelley, R. L.; Kilbourne, C. A.; Porter, F. S.; Sadleir, J. E.; Smith, S. J.; Sultana, M.

    2012-01-01

    Microcalorimeters onboard future x-ray observatories require an anticoincidence detector to remove environmental backgrounds. In order to most effectively integrate this anti-coincidence detector with the main microcalorimeter array, both instruments should use similar read-out technology. The detectors used in the Cryogenic Dark Matter Search (CDMS) use a phonon measurement technique that is well suited for an anti-coincidence detector with a microcalorimeter array using SQUID readout. This technique works by using a transition-edge sensor (TES) connected to superconducting collection fins to measure the athermal phonon signal produced when an event occurs in the substrate crystal. Energy from the event propagates through the crystal to the superconducting collection fins, creating quasiparticles, which are then trapped as they enter the TES where they produce a signal. We are currently developing a prototype anti-coincidence detector for future x-ray missions and have recently fabricated test devices with Mo/Au TESs and Al collection fins. We present results from the first tests of these devices which indicate a proof of concept that quasiparticle trapping is occurring in these materials.

  13. Modelling Random Coincidences in Positron Emission Tomography by Using Singles and Prompts: A Comparison Study

    Science.gov (United States)

    2016-01-01

    Random coincidences degrade the image in Positron Emission Tomography, PET. To compensate for their degradation effects, the rate of random coincidences should be estimated. Under certain circumstances, current estimation methods fail to provide accurate results. We propose a novel method, “Singles–Prompts” (SP), that includes the information conveyed by prompt coincidences and models the pile–up. The SP method has the same structure than the well-known “Singles Rate” (SR) approach. Hence, SP can straightforwardly replace SR. In this work, the SP method has been extensively assessed and compared to two conventional methods, SR and the delayed window (DW) method, in a preclinical PET scenario using Monte–Carlo simulations. SP offers accurate estimates for the randoms rates, while SR and DW tend to overestimate the rates (∼10%, and 5%, respectively). With pile-up, the SP method is more robust than SR (but less than DW). At the image level, the contrast is overestimated in SR-corrected images, +16%, while SP produces the correct value. Spill–over is slightly reduced using SP instead of SR. The DW images values are similar to those of SP except for low-statistic scenarios, where DW behaves as if randoms were not compensated for. In particular, the contrast is reduced, −16%. In general, the better estimations of SP translate into better image quality. PMID:27603143

  14. Detecting gravitational waves from inspiraling binaries with a network of detectors coherent versus coincident strategies

    CERN Document Server

    Mukhopadhyay, H; Kanda, H T N; Sago, N; Tagoshi, H; Dhurandhar, Sanjeev; Kanda, Hirotaka Takahashi & Nobuyuki; Mukhopadhyay, Himan; Sago, Norichica; Tagoshi, Hideyuki

    2006-01-01

    We compare two strategies of multi-detector detection of compact binary inspiral signals, namely, the coincidence and the coherent. For simplicity we consider here two identical detectors having the same power spectral density of noise, that of initial LIGO, located in the same place and having the same orientation. We consider the cases of independent noise as well as that of correlated noise. The coincident strategy involves separately making two candidate event lists, one for each detector, and from these choosing those pairs of events from the two lists which lie within a suitable parameter window, which then are called as coincidence detections. The coherent strategy on the other hand involves combining the data phase coherently, so as to obtain a single network statistic which is then compared with a single threshold. Here we attempt to shed light on the question as to which strategy is better. We compare the performances of the two methods by plotting the Receiver Operating Characteristics (ROC) for th...

  15. New approach to calculate the true-coincidence effect of HpGe detector

    Energy Technology Data Exchange (ETDEWEB)

    Alnour, I. A., E-mail: aaibrahim3@live.utm.my, E-mail: ibrahim.elnour@yahoo.com [Department of Physics, Faculty of Pure and Applied Science, International University of Africa, 12223 Khartoum (Sudan); Wagiran, H. [Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Skudai,Johor (Malaysia); Ibrahim, N. [Faculty of Defence Science and Technology, National Defence University of Malaysia, Kem Sungai Besi, 57000 Kuala Lumpur (Malaysia); Hamzah, S.; Elias, M. S. [Malaysia Nuclear Agency (MNA), Bangi, 43000 Kajang, Selangor D.E. (Malaysia); Siong, W. B. [Chemistry Department, Faculty of Resource Science & Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak (Malaysia)

    2016-01-22

    The corrections for true-coincidence effects in HpGe detector are important, especially at low source-to-detector distances. This work established an approach to calculate the true-coincidence effects experimentally for HpGe detectors of type Canberra GC3018 and Ortec GEM25-76-XLB-C, which are in operation at neutron activation analysis lab in Malaysian Nuclear Agency (NM). The correction for true-coincidence effects was performed close to detector at distances 2 and 5 cm using {sup 57}Co, {sup 60}Co, {sup 133}Ba and {sup 137}Cs as standard point sources. The correction factors were ranged between 0.93-1.10 at 2 cm and 0.97-1.00 at 5 cm for Canberra HpGe detector; whereas for Ortec HpGe detector ranged between 0.92-1.13 and 0.95-100 at 2 and 5 cm respectively. The change in efficiency calibration curve of the detector at 2 and 5 cm after correction was found to be less than 1%. Moreover, the polynomial parameters functions were simulated through a computer program, MATLAB in order to find an accurate fit to the experimental data points.

  16. [Study of reference material for excitation spectrum wavelength calibration of fluorescence spectrophotometer].

    Science.gov (United States)

    Chen, Xiao-bo; Kang, Dong-guo; Zhao, Cheng-yi; Li, Song; Wu, Zheng-long; Ma, Hui; Liu, Zhong-min; Zheng, Zhe

    2005-07-01

    A reference material used for wavelength calibration of fluorescence spectrophotometer was found. The holmium doped oxide reference material GBW(E) 130112 is a kind of standard reference material for absorption spectrophotometer. It can emit 547.7 nm fluorescence when excited by xenon lamp light. The excitation spectrum of 547.7 nm fluorescence was measured. It was found that the measured peaks of excitation spectrum are positioned at 333.56, 360.43 and 418.39 nm, respectively, which are coincident with the true values 333.8, 360.9 and 418.5 nm of reference material certification. It was illustrated that the holmium doped oxide reference material GBW(E)130112 could be used as reference material for the excitation wavelength calibration of the fluorescence spectrophotometer. Its property could be enhanced very much if high luminescent efficiency material is selected as rare earth ion doped matrix, and the purity is enhanced to reduce the cross relaxation.

  17. Synthesis and Fluorescence Spectra of Triazolylcoumarin Fluorescent Dyes

    Institute of Scientific and Technical Information of China (English)

    PENG Xian-fu; LI Hong-qi

    2009-01-01

    Much attention is devoted to fluorescent dyes especially those with potential in versatile applications. Reactions under "click" conditions between nonfluorescent 3 - azidocoumarins and terminal alkynes produced 3 -(1, 2, 3- triazol- 1 - yl)cournarins, a novel type of fluorescent dyes with intense fluorescence. The structures of the new coumarins were characterized by 1H NMR, MS, and IR spectra. Fluorescence spectra measurement demonstrated excellent fluorescence performance of the triazolylcoumarins and this click reaction is a promising candidate for bioconjugation and bioimaging applications since both azide and alkynes are quite inert to biological systems.

  18. Fluorescence nanoscopy. Methods and applications

    OpenAIRE

    Requejo-Isidro, Jose

    2013-01-01

    Fluorescence nanoscopy refers to the experimental techniques and analytical methods used for fluorescence imaging at a resolution higher than conventional, diffraction-limited, microscopy. This review explains the concepts behind fluorescence nanoscopy and focuses on the latest and promising developments in acquisition techniques, labelling strategies to obtain highly detailed super-resolved images and in the quantitative methods to extract meaningful information from them.

  19. Imaging photoelectron circular dichroism of chiral molecules by femtosecond multiphoton coincidence detection.

    Science.gov (United States)

    Lehmann, C Stefan; Ram, N Bhargava; Powis, Ivan; Janssen, Maurice H M

    2013-12-21

    Here, we provide a detailed account of novel experiments employing electron-ion coincidence imaging to discriminate chiral molecules. The full three-dimensional angular scattering distribution of electrons is measured after photoexcitation with either left or right circular polarized light. The experiment is performed using a simplified photoelectron-photoion coincidence imaging setup employing only a single particle imaging detector. Results are reported applying this technique to enantiomers of the chiral molecule camphor after three-photon ionization by circularly polarized femtosecond laser pulses at 400 nm and 380 nm. The electron-ion coincidence imaging provides the photoelectron spectrum of mass-selected ions that are observed in the time-of-flight mass spectra. The coincident photoelectron spectra of the parent camphor ion and the various fragment ions are the same, so it can be concluded that fragmentation of camphor happens after ionization. We discuss the forward-backward asymmetry in the photoelectron angular distribution which is expressed in Legendre polynomials with moments up to order six. Furthermore, we present a method, similar to one-photon electron circular dichroism, to quantify the strength of the chiral electron asymmetry in a single parameter. The circular dichroism in the photoelectron angular distribution of camphor is measured to be 8% at 400 nm. The electron circular dichroism using femtosecond multiphoton excitation is of opposite sign and about 60% larger than the electron dichroism observed before in near-threshold one-photon ionization with synchrotron excitation. We interpret our multiphoton ionization as being resonant at the two-photon level with the 3s and 3p Rydberg states of camphor. Theoretical calculations are presented that model the photoelectron angular distribution from a prealigned camphor molecule using density functional theory and continuum multiple scattering X alpha photoelectron scattering calculations

  20. Construction of a {gamma}-{gamma} and {beta}-{gamma} coincidence measurement system for precise determination of nuclear data

    Energy Technology Data Exchange (ETDEWEB)

    Furutaka, Kazuyoshi; Nakamura, Shoji; Harada, Hideo; Katoh, Toshio [Japan Nuclear Cycle Development Institute, Tokai Works, Tokai, Ibaraki (Japan)

    1999-03-01

    A {gamma}-{gamma} and {beta}-{gamma} coincidence measurement system was constructed for the precise determination of nuclear data, such as thermal neutron capture cross sections and {gamma}-ray emission probabilities. The validity of the system was tested by a {gamma}-{gamma} coincidence measurement with a {sup 60}Co standard source. (author)

  1. Delayed fluorescence in photosynthesis.

    Science.gov (United States)

    Goltsev, Vasilij; Zaharieva, Ivelina; Chernev, Petko; Strasser, Reto J

    2009-01-01

    Photosynthesis is a very efficient photochemical process. Nevertheless, plants emit some of the absorbed energy as light quanta. This luminescence is emitted, predominantly, by excited chlorophyll a molecules in the light-harvesting antenna, associated with Photosystem II (PS II) reaction centers. The emission that occurs before the utilization of the excitation energy in the primary photochemical reaction is called prompt fluorescence. Light emission can also be observed from repopulated excited chlorophylls as a result of recombination of the charge pairs. In this case, some time-dependent redox reactions occur before the excitation of the chlorophyll. This delays the light emission and provides the name for this phenomenon-delayed fluorescence (DF), or delayed light emission (DLE). The DF intensity is a decreasing polyphasic function of the time after illumination, which reflects the kinetics of electron transport reactions both on the (electron) donor and the (electron) acceptor sides of PS II. Two main experimental approaches are used for DF measurements: (a) recording of the DF decay in the dark after a single turnover flash or after continuous light excitation and (b) recording of the DF intensity during light adaptation of the photosynthesizing samples (induction curves), following a period of darkness. In this paper we review historical data on DF research and recent advances in the understanding of the relation between the delayed fluorescence and specific reactions in PS II. An experimental method for simultaneous recording of the induction transients of prompt and delayed chlorophyll fluorescence and decay curves of DF in the millisecond time domain is discussed.

  2. High-level neutron-coincidence-counter (HLNCC) implementation: assay of the plutonium content of mixed-oxide fuel assemblies

    Energy Technology Data Exchange (ETDEWEB)

    Foley, J E; Bosler, G E

    1982-04-01

    The portable High-Level Neutron Coincidence Counter is used to assay the /sup 240/Pu-effective loading of a reference mixed-oxide fuel assembly by neutron coincidence counting. We have investigated the effects on the coincidence count rate of the total fuel loading (UO/sub 2/ + PuO/sub 2/), the fissile loading, the fuel rod diameter, and the fuel rod pattern. The coincidence count rate per gram of /sup 240/Pu-effective per centimeter is primarily dependent on the total fuel loading of the assembly; the higher the loading, the higher the coincidence count rate. Detailed procedures for the assay of mixed-oxide fuel assemblies are developed.

  3. Coincidence Lattices and Interlayer Twist in van der Waals Heterostructures: Application of the Coincidence Lattice Method on \\hbox {hBN/MoSe}_2 Heterobilayer Systems

    Science.gov (United States)

    Koda, Daniel S.; Bechstedt, Friedhelm; Marques, Marcelo; Teles, Lara K.

    2017-07-01

    Van der Waals heterostructures have great potential in large-scale integration devices and exploration of new physics. Experimental investigations allow flexible combinations of two-dimensional crystals in device fabrications. Theory, however, has limitations of supercell sizes and commensurability, translated into computational effort. In this work, we demonstrate the application of the coincidence lattice method to simulate two \\hbox {hBN/MoSe}_2 heterobilayers taking interlayer twist effects into account. We predict that both systems are stable upon contact and interact via van der Waals dispersions. We found that electronic properties of \\hbox {MoSe}_2 are preserved for both simulated systems, but hBN suffers from the increase of interface interactions, as evidenced by band structures and density of states calculations. Finally, band discontinuities are obtained and charge transfer arguments explain small shifts in band offsets with respect to natural alignments. We conclude that hBN is a reasonable substrate for preserving useful properties of \\hbox {MoSe}_2 for application in electronic and optoelectronic devices, and that interlayer twist angles play a significant role in the physics of van der Waals heterostructures.

  4. Marrow Adipose Tissue Expansion Coincides with Insulin Resistance in MAGP1-Deficient Mice.

    Science.gov (United States)

    Walji, Tezin A; Turecamo, Sarah E; Sanchez, Alejandro Coca; Anthony, Bryan A; Abou-Ezzi, Grazia; Scheller, Erica L; Link, Daniel C; Mecham, Robert P; Craft, Clarissa S

    2016-01-01

    Marrow adipose tissue (MAT) is an endocrine organ with the potential to influence skeletal remodeling and hematopoiesis. Pathologic MAT expansion has been studied in the context of severe metabolic challenge, including caloric restriction, high fat diet feeding, and leptin deficiency. However, the rapid change in peripheral fat and glucose metabolism associated with these models impedes our ability to examine which metabolic parameters precede or coincide with MAT expansion. Microfibril-associated glycoprotein-1 (MAGP1) is a matricellular protein that influences cellular processes by tethering signaling molecules to extracellular matrix structures. MAGP1-deficient (Mfap2 (-/-)) mice display a progressive excess adiposity phenotype, which precedes insulin resistance and occurs without changes in caloric intake or ambulation. Mfap2 (-/-) mice were, therefore, used as a model to associate parameters of metabolic disease, bone remodeling, and hematopoiesis with MAT expansion. Marrow adiposity was normal in Mfap2 (-/-) mice until 6 months of age; however, by 10 months, marrow fat volume had increased fivefold relative to wild-type control at the same age. Increased gonadal fat pad mass and hyperglycemia were detectable in Mfap2 (-/-) mice by 2 months, but peaked by 6 months. The development of insulin resistance coincided with MAT expansion. Longitudinal characterization of bone mass demonstrated a disconnection in MAT volume and bone volume. Specifically, Mfap2 (-/-) mice had reduced trabecular bone volume by 2 months, but this phenotype did not progress with age or MAT expansion. Interestingly, MAT expansion in the 10-month-old Mfap2 (-/-) mice was associated with modest alterations in basal hematopoiesis, including a shift from granulopoiesis to B lymphopoiesis. Together, these findings indicate MAT expansion is coincident with insulin resistance, but not excess peripheral adiposity or hyperglycemia in Mfap2 (-/-) mice; and substantial MAT accumulation does

  5. Phasic Firing and Coincidence Detection by Subthreshold Negative Feedback: Divisive or Subtractive or, Better, Both

    Science.gov (United States)

    Huguet, Gemma; Meng, Xiangying; Rinzel, John

    2017-01-01

    Phasic neurons typically fire only for a fast-rising input, say at the onset of a step current, but not for steady or slow inputs, a property associated with type III excitability. Phasic neurons can show extraordinary temporal precision for phase locking and coincidence detection. Exemplars are found in the auditory brain stem where precise timing is used in sound localization. Phasicness at the cellular level arises from a dynamic, voltage-gated, negative feedback that can be recruited subthreshold, preventing the neuron from reaching spike threshold if the voltage does not rise fast enough. We consider two mechanisms for phasicness: a low threshold potassium current (subtractive mechanism) and a sodium current with subthreshold inactivation (divisive mechanism). We develop and analyze three reduced models with either divisive or subtractive mechanisms or both to gain insight into the dynamical mechanisms for the potentially high temporal precision of type III-excitable neurons. We compare their firing properties and performance for a range of stimuli. The models have characteristic non-monotonic input-output relations, firing rate vs. input intensity, for either stochastic current injection or Poisson-timed excitatory synaptic conductance trains. We assess performance according to precision of phase-locking and coincidence detection by the models' responses to repetitive packets of unitary excitatory synaptic inputs with more or less temporal coherence. We find that each mechanism contributes features but best performance is attained if both are present. The subtractive mechanism confers extraordinary precision for phase locking and coincidence detection but only within a restricted parameter range when the divisive mechanism of sodium inactivation is inoperative. The divisive mechanism guarantees robustness of phasic properties, without compromising excitability, although with somewhat less precision. Finally, we demonstrate that brief transient inhibition if

  6. A beta-ray spectrometer based on a two-or three silicon detector coincidence telescope

    Energy Technology Data Exchange (ETDEWEB)

    Horowitz, Y.S. [Ben-Gurion Univ. of the Negev, Beersheba (Israel). Dept. of Physics; Weizman, Y. [Ben-Gurion Univ. of the Negev, Beersheba (Israel). Dept. of Physics; Hirning, C.R. [Health Physics Dept., Ontario Hydro, Whitby (Canada)

    1995-03-11

    This report describes the operation of a beta-ray energy spectrometer based on a silicon detector telescope using two or three elements. The front detector is a planar, totally-depleted, silicon surface barrier detector that is 97 {mu}m thick, the back detector is a room-temperature, lithium compensated, silicon detector that is 5000 {mu}m thick, and the intermediate detector is similar to the front detector but 72 {mu}m thick and intended to be used only in intense photon fields. The three detectors are mounted in a light-tight aluminum housing. The capability of the spectrometer to reject photons is based upon the fact that the incident photon will have a small probability of simultaneously losing detectable energy in two detectors, and an even smaller probability of losing detectable energy in all three detectors. Electrons will, however, almost always record measurable events in either the front two or all three detectors. A coincidence requirement between the detectors thus rejects photon induced events. With a 97 {mu}m thick detector the lower energy coincidence threshold is approximately 110 keV. With an ultra-thin 40 {mu}m thick front detector, and operated at 15 C, the spectrometer is capable of detecting even 60-70 keV electrons with a coincidence efficiency of 60%. The spectrometer has been used to measure beta radiation fields in CANDU reactor working environments, and the spectral information is intended to support dose algorithms for the LiF TLD chips used in the Ontario Hydro dosimetry program. (orig.).

  7. Measurements of beta ray spectra in CANDU nuclear generating stations using a silicon detector coincidence telescope

    Energy Technology Data Exchange (ETDEWEB)

    Horowitz, Y.S.; Weizman, Y. [Ben-Gurion Univ. of the Negev, Beersheba (Israel). Dept. of Physics; Hirning, C.R. [Ontario Hydro, Whitby, ON (Canada). Health Physics Dept.

    1996-12-31

    The measurement of beta ray spectra at various work locations inside nuclear generating stations operated by Ontario Hydro is described. The measurements were carried out using an advanced coincidence telescope spectrometer using silicon detectors only. The spectrometer is capable of measuring electron energies over the range 60 keV- 2500 keV with close to 100% coincidence efficiency. Photon rejection is carried out by requiring a coincidence between either two or three silicon detectors. Monte Carlo calculations were then used to estimate beta correction factors for the LiF:Mg,Ti elements used in the Ontario Hydro thermoluminescence dosemeters. Averaging over all the measured beta correction factors for the `skin` chip (100 mg.cm{sup -2}) results in a value of 2.73 {+-} 0.77 and for the extremity dosemeter (240 mg.cm{sup -2}) an average value of 4.42 {+-} 1.17 is obtained. These values are 57% and 120% greater, respectively, than the current values used by Ontario Hydro. In addition, beta correction factors for nine representative spectra were calculated for 40 mg.cm{sup -2} chips and 20 mg.cm{sup -2} chips and the results demonstrate the benefits of decreased dosemeter thickness. The average value of the beta correction factor, as well as the spread in the beta correction factor, decreases dramatically from 4.8 {+-} 2.1 (240 mg.cm{sup -2}) to 1.29 ``1.2`` +-`` 0.1 (20 mg.cm{sup -2}). (author).

  8. Coincidence detection of convergent perforant path and mossy fibre inputs by CA3 interneurons.

    Science.gov (United States)

    Calixto, Eduardo; Galván, Emilio J; Card, J Patrick; Barrionuevo, Germán

    2008-06-01

    We performed whole-cell recordings from CA3 s. radiatum (R) and s. lacunosum-moleculare (L-M) interneurons in hippocampal slices to examine the temporal aspects of summation of converging perforant path (PP) and mossy fibre (MF) inputs. PP EPSPs were evoked from the s. lacunosum-moleculare in area CA1. MF EPSPs were evoked from the medial extent of the suprapyramidal blade of the dentate gyrus. Summation was strongly supralinear when examining PP EPSP with MF EPSP in a heterosynaptic pair at the 10 ms ISI, and linear to sublinear at longer ISIs. This pattern of nonlinearities suggests that R and L-M interneurons act as coincidence detectors for input from PP and MF. Summation at all ISIs was linear in voltage clamp mode demonstrating that nonlinearities were generated by postsynaptic voltage-dependent conductances. Supralinearity was not detected when the first EPSP in the pair was replaced by a simulated EPSP injected into the soma, suggesting that the conductances underlying the EPSP boosting were located in distal dendrites. Supralinearity was selectively eliminated with either Ni2+ (30 microm), mibefradil (10 microm) or nimodipine (15 microm), but was unaffected by QX-314. This pharmacological profile indicates that supralinearity is due to recruitment of dendritic T-type Ca2+channels by the first subthreshold EPSP in the pair. Results with the hyperpolarization-activated (Ih) channel blocker ZD 7288 (50 microm) revealed that Ih restricted the time course of supralinearity for coincidently summed EPSPs, and promoted linear to sublinear summation for asynchronous EPSPs. We conclude that coincidence detection results from the counterbalanced activation of T-type Ca2+ channels and inactivation of Ih.

  9. Effects of calcium spikes in the layer 5 pyramidal neuron on coincidence detection and activity propagation

    Directory of Open Access Journals (Sweden)

    Yansong Chua

    2016-07-01

    Full Text Available The role of dendritic spiking mechanisms in neural processing is so far poorly understood. To investigate the role of calcium spikes in the functional properties of the single neuron and recurrent networks, we investigated a three compartment neuron model of the layer 5 pyramidal neuron with calcium dynamics in the distal compartment. By performing single neuron simulations with noisy synaptic input and occasional large coincident input at either just the distal compartment or at both somatic and distal compartments, we show that the presence of calcium spikes confers a substantial advantage for coincidence detection in the former case and a lesser advantage in the latter. We further show that the experimentally observed critical frequency phenomenon is not exhibited by a neuron receiving realistically noisy synaptic input, and so is unlikely to be a necessary component of coincidence detection. We next investigate the effect of calcium spikes in propagation of spiking activities in a feed-forward network embedded in a balanced recurrent network. The excitatory neurons in the network are again connected to either just the distal, or both somatic and distal compartments. With purely distal connectivity, activity propagation is stable and distinguishable for a large range of recurrent synaptic strengths if the feed-forward connections are sufficiently strong, but propagation does not occur in the absence of calcium spikes. When connections are made to both the somatic and the distal compartments, activity propagation is achieved for neurons with active calcium dynamics at a much smaller number of neurons per pool, compared to a network of passive neurons, but quickly becomes unstable as the strength of recurrent synapses increases. Activity propagation at higher scaling factors can be stabilized by increasing network inhibition or introducing short term depression in the excitatory synapses, but the signal to noise ration remains low. Our results

  10. Utilization of coincidence criteria in absolute length measurements by optical interferometry in vacuum and air

    Science.gov (United States)

    Schödel, R.

    2015-08-01

    Traceability of length measurements to the international system of units (SI) can be realized by using optical interferometry making use of well-known frequencies of monochromatic light sources mentioned in the Mise en Pratique for the realization of the metre. At some national metrology institutes, such as Physikalisch-Technische Bundesanstalt (PTB) in Germany, the absolute length of prismatic bodies (e.g. gauge blocks) is realized by so-called gauge-block interference comparators. At PTB, a number of such imaging phase-stepping interference comparators exist, including specialized vacuum interference comparators, each equipped with three highly stabilized laser light sources. The length of a material measure is expressed as a multiple of each wavelength. The large number of integer interference orders can be extracted by the method of exact fractions in which the coincidence of the lengths resulting from the different wavelengths is utilized as a criterion. The unambiguous extraction of the integer interference orders is an essential prerequisite for correct length measurements. This paper critically discusses coincidence criteria and their validity for three modes of absolute length measurements: 1) measurements under vacuum in which the wavelengths can be identified with the vacuum wavelengths, 2) measurements under air in which the air refractive index is obtained from environmental parameters using an empirical equation, and 3) measurements under air in which the air refractive index is obtained interferometrically by utilizing a vacuum cell placed along the measurement pathway. For case 3), which corresponds to PTB’s Kösters-Comparator for long gauge blocks, the unambiguous determination of integer interference orders related to the air refractive index could be improved by about a factor of ten when an ‘overall dispersion value,’ suggested in this paper, is used as coincidence criterion.

  11. Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology.

    Science.gov (United States)

    Toledo, Jon B; Gopal, Pallavi; Raible, Kevin; Irwin, David J; Brettschneider, Johannes; Sedor, Samantha; Waits, Kayla; Boluda, Susana; Grossman, Murray; Van Deerlin, Vivianna M; Lee, Edward B; Arnold, Steven E; Duda, John E; Hurtig, Howard; Lee, Virginia M-Y; Adler, Charles H; Beach, Thomas G; Trojanowski, John Q

    2016-03-01

    We investigated the distribution patterns of Lewy body-related pathology (LRP) and the effect of coincident Alzheimer disease (AD) pathology using a data-driven clustering approach that identified groups with different LRP pathology distributions without any diagnostic or researcher's input in two cohorts including: Parkinson disease patients without (PD, n = 141) and with AD (PD-AD, n = 80), dementia with Lewy bodies subjects without AD (DLB, n = 13) and demented subjects with AD and LRP pathology (Dem-AD-LB, n = 308). The Dem-AD-LB group presented two LRP patterns, olfactory-amygdala and limbic LRP with negligible brainstem pathology, that were absent in the PD groups, which are not currently included in the DLB staging system and lacked extracranial LRP as opposed to the PD group. The Dem-AD-LB individuals showed relative preservation of substantia nigra cells and dopamine active transporter in putamen. PD cases with AD pathology showed increased LRP. The cluster with occipital LRP was associated with non-AD type dementia clinical diagnosis in the Dem-AD-LB group and a faster progression to dementia in the PD groups. We found that (1) LRP pathology in Dem-AD-LB shows a distribution that differs from PD, without significant brainstem or extracranial LRP in initial phases; (2) coincident AD pathology is associated with increased LRP in PD indicating an interaction; (3) LRP and coincident AD pathology independently predict progression to dementia in PD, and (4) evaluation of LRP needs to acknowledge different LRP spreading patterns and evaluate substantia nigra integrity in the neuropathological assessment and consider the implications of neuropathological heterogeneity for clinical and biomarker characterization.

  12. One-nucleon channels of the /sup 16/O disintegration in a coincidence experiment

    Energy Technology Data Exchange (ETDEWEB)

    Kirpichnikov, I.V.; Kuznetsov, V.A.; Starostin, A.S. (Institut Teoreticheskoj i Ehksperimental' noj Fiziki, Moscow (USSR)); Kislyakov, E.F.; Korotkikh, V.L.; Lanskoy, D.E. (Moskovskij Gosudarstvennyj Univ. (USSR). Nauchno-Issledovatel' skij Inst. Yadernoj Fiziki)

    1983-01-17

    The differential cross sections for the reactions /sup 16/O(..pi../sup +/, ..pi../sup +/p)/sup 15/Nsup(*)(6.32 MeV) and /sup 16/O(..pi../sup +/, ..pi../sup +/n)/sup 15/Osup(*)(6.18 MeV) are measured with a 2.0 GeV/c pion beam in a ..pi../sup +/..gamma.. coincidence experiment. Calculations in the framework of the unified theory of nuclear disintegration are in qualitative agreement with the experimental data.

  13. An application of the coincidence Doppler spectroscopy for substances of chemical interest: phthalocyanine and acetylacetonate complexes

    CERN Document Server

    Ito, Y

    2000-01-01

    Coincidence Doppler spectroscopy, which is particularly powerful when one is concerned with high momentum components of positron annihilation gamma-rays, has been applied to two different kinds of organo-metallic ligands: metal phthalocyanines and metal acetylacetonates. The energy (momentum) profiles of the annihilation gamma-rays were the same for metal phthalocyanines indicating that positron and/or positronium are not interacting with the metal ions. However, the profiles for the metal acetylacetonates evidently showed a dependence on the kind of metal ions. Discussion is made on the features of positron interaction which are different for phthalocyanines and acetylacetonates.

  14. Dynamic spike threshold and nonlinear dendritic computation for coincidence detection in neuromorphic circuits.

    Science.gov (United States)

    Hsu, Chih-Chieh; Parker, Alice C

    2014-01-01

    We present an electronic cortical neuron incorporating dynamic spike threshold and active dendritic properties. The circuit is simulated using a carbon nanotube field-effect transistor SPICE model. We demonstrate that our neuron has lower spike threshold for coincident synaptic inputs; however when the synaptic inputs are not in synchrony, it requires larger depolarization to evoke the neuron to fire. We also demonstrate that a dendritic spike is key to precisely-timed input-output transformation, produces reliable firing and results in more resilience to input jitter within an individual neuron.

  15. Coincidence of remission of postpartum Graves' disease and use of omega-3 fatty acid supplements

    Directory of Open Access Journals (Sweden)

    Breese McCoy Sarah J

    2011-11-01

    Full Text Available Abstract I developed Graves' Disease four months postpartum. After one year on propylthiouracil, I learned that omega-3 fatty acids may reduce inflammation associated with certain autoimmune disorders, although no investigations for thyroiditis have been reported. Within eight weeks of beginning flaxseed oil supplements, TSH levels normalized, but fell somewhat when flaxseed was decreased and PTU discontinued. During another pregnancy, plasma TSH normalized, but was again suppressed by four weeks postpartum, then undetectable by four months. This time, flaxseed supplementation alone coincided with TSH normalization. Omega-3 fatty acids should be investigated as a potential treatment for autoimmune thyroid disease.

  16. Optimization of a coincidence system using plastic scintillators in 4pi geometry.

    Science.gov (United States)

    Dias, M S; Piuvezam-Filho, H; Koskinas, M F

    2008-01-01

    Improvements recently developed at the Nuclear Metrology Laboratory of IPEN-CNEN/SP in São Paulo were performed in order to increase the detector efficiency of a 4pibeta-gamma coincidence primary system using plastic scintillators in 4pi geometry. Measurements were undertaken and compared to the original system and Monte Carlo simulations of the extrapolation curves were calculated for this new system and compared to experimental results. For this purpose, the code Penelope was applied for calculating response functions for each detector and the code Esquema, developed at LMN, was used for simulating the decay scheme processes.

  17. Solving the coincidence problem in a large class of running vacuum cosmologies

    CERN Document Server

    Zilioti, G J M; Lima, J A S

    2015-01-01

    Decaying vacuum cosmological models evolving smoothly between two extreme (very early and late time) de Sitter phases are capable to solve naturally several cosmic problems, among them: (i) the singularity, (ii) the horizon, (iii) the graceful-exit from inflation. Here we discuss a solution the coincidence problem based on a large class of running vacuum cosmologies evolving from de Sitter to de Sitter recently proposed. It is argued that even the cosmological constant problem can be solved provided that the characteristic scales of the limiting de Sitter manifolds are predicted from first principles.

  18. On the Imbedding Problem for Three-state Time Homogeneous Markov Chains with Coinciding Negative Eigenvalues

    CERN Document Server

    Chen, Yong

    2010-01-01

    For an indecomposable $3\\times 3$ stochastic matrix (i.e., 1-step transition probability matrix) with coinciding negative eigenvalues, a new necessary and sufficient condition of the imbedding problem for time homogeneous Markov chains is shown by means of an alternate parameterization of the transition rate matrix (i.e., intensity matrix, infinitesimal generator), which avoids calculating matrix logarithm or matrix square root. In addition, an implicit description of the imbedding problem for the $3\\times 3$ stochastic matrix in Johansen [J. Lond. Math. Soc., 8, 345-351. (1974)] is pointed out.

  19. Detector Description and Performance for the First Coincidence Observations between LIGO and GEO

    CERN Document Server

    Abbott, B; Adhikari, R; Allen, B; Amin, R; Anderson, S B; Anderson, W G; Araya, M; Armandula, H; Asiri, F; Aufmuth, P; Aulbert, C; Babak, S V; Balasubramanian, R; Ballmer, S; Barish, B C; Barker, D; Barker-Patton, C; Barnes, M; Barr, B; Barton, M A; Bayer, K; Beausoleil, R; Belczynski, K; Bennett, R; Berukoff, S J; Betzwieser, J; Bhawal, B; Billingsley, G; Black, E; Blackburn, K; Bland-Weaver, B; Bochner, B; Bogue, L; Bork, R G; Bose, S; Brady, P R; Brau, J E; Brown, D A; Brozek, S; Bullington, A; Buonanno, A; Burgess, R; Busby, D; Butler, W E; Byer, R L; Cadonati, L; Cagnoli, G; Camp, J B; Cantley, C A; Cardenas, L; Carter, K; Casey, M M; Castiglione, J; Chandler, A; Chapsky, J; Charlton, P; Chatterji, S; Chen, Y; Chickarmane, V; Chin, D; Christensen, N; Churches, D; Colacino, C N; Coldwell, R; Coles, M; Cook, D; Corbitt, T; Coyne, D; Creighton, J D E; Creighton, T D; Crooks, D R M; Csatorday, P; Cusack, B J; Cutler, C; D'Ambrosio, E; Danzmann, K; Davies, R; Daw, E; De Bra, D; Delker, T; DeSalvo, R; Dhurandhar, S V; Ding, H; Drever, R W P; Dupuis, R J; Ebeling, C; Edlund, J; Ehrens, P; Elliffe, E J; Etzel, T; Evans, M; Evans, T; Fallnich, C; Farnham, D; Fejer, M M; Fine, M; Finn, L S; Flanagan, E; Freise, A; Frey, R; Fritschel, P; Frolov, V; Fyffe, M; Ganezer, K S; Giaime, J A; Gillespie, A; Goda, K; González, G; Gossler, S; Grandclément, P; Grant, A; Gray, C; Gretarsson, A M; Grimmett, D; Grote, H; Grünewald, S; Günther, M; Gustafson, E; Gustafson, R; Hamilton, W O; Hammond, M; Hanson, J; Hardham, C; Harry, G; Hartunian, A; Heefner, J; Hefetz, Y; Heinzel, G; Heng, I S; Hennessy, M; Hepler, N; Heptonstall, A; Heurs, M; Hewitson, M; Hindman, N; Hoang, P; Hough, J; Hrynevych, M; Hua, W; Ingley, R; Ito, M; Itoh, Y; Ivanov, A; Jennrich, O; Johnson, W W; Johnston, W; Jones, L; Jungwirth, D; Kalogera, V; Katsavounidis, E; Kawabe, K; Kawamura, S; Kells, W; Kern, J; Khan, A; Killbourn, S; Killow, C J; Kim, C; King, C; King, P; Klimenko, S; Kloevekorn, P; Koranda, S; Kotter, K; Kovalik, Yu; Kozak, D; Krishnan, B; Landry, M; Langdale, J; Lantz, B; Lawrence, R; Lazzarini, A; Lei, M; Leonhardt, V; Leonor, I; Libbrecht, K; Lindquist, P; Liu, S; Logan, J; Lormand, M; Lubinski, M; Lück, H B; Lyons, T T; Machenschalk, B; MacInnis, M; Mageswaran, M; Mailand, K; Majid, W A; Malec, M; Mann, F; Marin, A; Marka, S; Maros, E; Mason, J; Mason, K; Matherny, O; Matone, L; Mavalvala, N; McCarthy, R; McClelland, D E; McHugh, M; McNamara, P; Mendell, G; Meshkov, S; Messenger, C; Mitselmakher, G; Mittleman, R; Miyakawa, O; Miyoki, S; Mohanty, S; Moreno, G; Mossavi, K; Mours, B; Müller, G; Mukherjee, S; Myers, J; Nagano, S; Nash, T; Naundorf, H; Nayak, R; Newton, G; Nocera, F; Nutzman, P; Olson, T; O'Reilly, B; Ottaway, D J; Ottewill, A; Ouimette, D A; Overmier, H; Owen, B J; Papa, M A; Parameswariah, C; Parameshwaraiah, V; Pedraza, M; Penn, S; Pitkin, M; Plissi, M; Pratt, M; Quetschke, V; Raab, F; Radkins, H; Rahkola, R; Rakhmanov, M; Rao, S R; Redding, D; Regehr, M W; Regimbau, T; Reilly, K T; Reithmaier, K; Reitze, D H; Richman, S; Riesen, R; Riles, K; Rizzi, A; Robertson, D I; Robertson, N A; Robison, L; Roddy, S; Rollins, J; Romano, J D; Romie, J; Rong, H; Rose, D; Rotthoff, E; Rowan, S; Rüdiger, A; Russell, P; Ryan, K; Salzman, I; Sanders, G H; Sannibale, V; Sathyaprakash, B; Saulson, P R; Savage, R; Sazonov, A; Schilling, R; Schlaufman, K; Schmidt, V; Schofield, R; Schrempel, M; Schutz, B F; Schwinberg, P; Scott, S M; Searle, A C; Sears, B; Seel, S; Sengupta, A S; Shapiro, C A; Shawhan, P S; Shoemaker, D H; Shu, Q Z; Sibley, A; Siemens, X; Sievers, L; Sigg, D; Sintes, A M; Skeldon, K D; Smith, J R; Smith, M; Smith, M R; Sneddon, P; Spero, R; Stapfer, G; Strain, K A; Strom, D; Stuver, A; Summerscales, T; Sumner, M C; Sutton, P J; Sylvestre, J; Takamori, A; Tanner, D B; Tariq, H; Taylor, I; Taylor, R; Thorne, K S; Tibbits, M; Tilav, S; Tinto, M; Torres, C; Torrie, C; Traeger, S; Traylor, G; Tyler, W; Ugolini, D W; Vallisneri, M; Van Putten, M H P M; Vass, S; Vecchio, A; Vorvick, C; Wallace, L; Walther, H; Ward, H; Ware, B; Watts, K; Webber, D; Weidner, A; Weiland, U; Weinstein, A; Weiss, R; Welling, H; Wen, L; Wen, S; Whelan, J T; Whitcomb, S E; Whiting, B F; Willems, P A; Williams, P R; Williams, R; Willke, B; Wilson, A; Winjum, B J; Winkler, W; Wise, S; Wiseman, A G; Woan, G; Wooley, R; Worden, J; Yakushin, I; Yamamoto, H; Yoshida, S; Zawischa, I; Zhang, L; Zotov, N P; Zucker, M; Zweizig, J

    2004-01-01

    For 17 days in August and September 2002, the LIGO and GEO interferometer gravitational wave detectors were operated in coincidence to produce their first data for scientific analysis. Although the detectors were still far from their design sensitivity levels, the data can be used to place better upper limits on the flux of gravitational waves incident on the earth than previous direct measurements. This paper describes the instruments and the data in some detail, as a companion to analysis papers based on the first data.

  20. Interaction between Dark Matter and Dark Energy and the Cosmological Coincidence Problem

    Directory of Open Access Journals (Sweden)

    Kourosh Nozari

    2014-01-01

    Full Text Available We consider a quintessence model of dark energy inspired by scalar-tensor theories of gravity where the scalar field is nonminimally coupled to gravity and dark matter. By considering exponential potential as self-interaction potential, the stability and existence of the critical points are discussed in details. With nonminimally coupled dark sector with gravity, we obtain scaling solutions to address the coincidence problem by considering complex velocity for dark matter. The statefinder diagnostic shows that the equation of state reaches ΛCDM model in the future.

  1. Efficiency-optimized low-cost TDPAC spectrometer using a versatile routing/coincidence unit

    Energy Technology Data Exchange (ETDEWEB)

    Renteria, M., E-mail: renteria@fisica.unlp.edu.ar; Bibiloni, A. G.; Darriba, G. N.; Errico, L. A.; Munoz, E. L.; Richard, D.; Runco, J. [Universidad Nacional de La Plata, Departamento de Fisica, Facultad de Ciencias Exactas (Argentina)

    2008-01-15

    A highly efficient, reliable, and low-cost {gamma}-{gamma} TDPAC spectrometer, PACAr, optimized for {sup 181}Hf-implanted low-activity samples, is presented. A versatile EPROM-based routing/coincidence unit was developed and implemented to be use with the memory-card-based multichannel analyzer hosted in a personal computer. The excellent energy resolution and very good overall resolution and efficiency of PACAr are analyzed and compare with advanced and already tested fast-fast and slow-fast PAC spectrometers.

  2. Measurement of $\\gamma\\gamma$-coincidences and $^{152}Tb \\to ^{152}Gd$ Decay Scheme

    CERN Document Server

    Adam, J; Honusek, M; Kalinnikov, V G; Mrazek, J; Pronskikh, V S; Caloun, P; Lebedev, N A; Stegailov, V I; Tsoupko-Sitnikov, V M

    2001-01-01

    On the basis of \\gamma\\gamma-coincidences recorded with two HPGe-detectors, 242 transitions were placed into the ^{152}Tb\\to^{152}Gd decay scheme, 131 of them - for the first time. Also, 46 new levels were introduced for the first time (out of 111). For a number of low-lying levels the electron capture to positron decay ratio was found. For the most of levels, their spins and parities were determined, as well as log ft's for feeding them decays.

  3. Constructing coincident indices of economic activity for the Latin American economy

    Directory of Open Access Journals (Sweden)

    João Victor Issler

    2013-03-01

    Full Text Available This paper has three main contributions. The first is to propose an individual coincident indicator for the following Latin American countries: Argentina, Brazil, Chile, Colombia and Mexico. In order to obtain similar series to those traditionally used in business-cycle research in constructing coincident indices (output, sales, income and employment we were forced to back-cast several individual country series which were not available in a long time-series span. The second contribution is to establish a chronology of recessions for these countries, covering the period from 1980 to 2012 on a monthly basis. Based on this chronology, the countries are compared in several respects. The final contribution is to propose an aggregate coincident indicator for the Latin American economy, which weights individual-country composite indices. Finally, this indicator is compared with the coincident indicator (The Conference Board - TCB of the U.S. economy. We find that the U.S. indicator Granger-causes the Latin American indicator in statistical testsEsse artigo tem 3 contribuições à literatura de ciclos de negócios. A primeira é a de construir indicadores coincidentes de atividade econômica para Argentina, Brasil, Chile, Colômbia e México, usando pesos idênticos para as séries de Emprego, Produção, Renda, e Vendas. Para tal, tivemos que fazer o back-cast de algumas séries chave para poder construir esses indicadores. A segunda é a de estabelecer uma cronologia de recessões para esses países no período 1980-2012 em bases mensais. Com base na última, fazemos comparações em várias dimensões. Finalmente, nossa última contribuição é propor um índice coincidente agregado para a América Latina, que é comparado ao índice agregado dos EUA. Esta comparação indica que o índice coincidente dos EUA Granger-causa o da América Latina, mas a recíproca não é verdadeira

  4. Versatile single-molecule multi-color excitation and detection fluorescence setup for studying biomolecular dynamics

    KAUST Repository

    Sobhy, M. A.

    2011-11-07

    Single-molecule fluorescence imaging is at the forefront of tools applied to study biomolecular dynamics both in vitro and in vivo. The ability of the single-molecule fluorescence microscope to conduct simultaneous multi-color excitation and detection is a key experimental feature that is under continuous development. In this paper, we describe in detail the design and the construction of a sophisticated and versatile multi-color excitation and emission fluorescence instrument for studying biomolecular dynamics at the single-molecule level. The setup is novel, economical and compact, where two inverted microscopes share a laser combiner module with six individual laser sources that extend from 400 to 640 nm. Nonetheless, each microscope can independently and in a flexible manner select the combinations, sequences, and intensities of the excitation wavelengths. This high flexibility is achieved by the replacement of conventional mechanical shutters with acousto-optic tunable filter (AOTF). The use of AOTF provides major advancement by controlling the intensities, duration, and selection of up to eight different wavelengths with microsecond alternation time in a transparent and easy manner for the end user. To our knowledge this is the first time AOTF is applied to wide-field total internal reflection fluorescence (TIRF) microscopy even though it has been commonly used in multi-wavelength confocal microscopy. The laser outputs from the combiner module are coupled to the microscopes by two sets of four single-mode optic fibers in order to allow for the optimization of the TIRF angle for each wavelength independently. The emission is split into two or four spectral channels to allow for the simultaneous detection of up to four different fluorophores of wide selection and using many possible excitation and photoactivation schemes. We demonstrate the performance of this new setup by conducting two-color alternating excitation single-molecule fluorescence resonance energy

  5. Development of a method for activity measurements of {sup 232}Th daughters with a multidetector gamma-ray coincidence spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Antovic, N. [Faculty of Natural Sciences and Mathematics, University of Montenegro, Cetinjski put b.b., 81000 Podgorica (Montenegro)], E-mail: antovicn@yahoo.com; Svrkota, N. [Center for Ecotoxicological Research, Put Radomira Ivanovica 2, 81000 Podgorica (Montenegro)

    2009-06-15

    The method for activity measurements of the {sup 232}Th daughters, developed at the six-crystal gamma-ray coincidence spectrometer PRIPYAT-2M and based on coincidence counting of the 583 and 2615 keV photons from cascade transitions which follow {beta}{sup -}-decay of {sup 208}Tl, as well as on counting the 911 keV photons which follow {beta}{sup -}-decay of {sup 228}Ac in the integral and non-coincidence mode of counting, is presented.

  6. A new 4π(LS)-γ coincidence counter at NCBJ RC POLATOM with TDCR detector in the beta channel.

    Science.gov (United States)

    Ziemek, T; Jęczmieniowski, A; Cacko, D; Broda, R; Lech, E

    2016-03-01

    A new 4π(LS)-γ coincidence system (TDCRG) was built at the NCBJ RC POLATOM. The counter consists of a TDCR detector in the beta channel and scintillation detector with NaI(Tl) crystal in the gamma channel. The system is equipped with a digital board with FPGA, which records and analyses coincidences in the TDCR detector and coincidences between the beta and gamma channels. The characteristics of the system and a scheme of the FPGA implementation with behavioral simulation are given. The TDCRG counter was validated by activity measurements on (14)C and (60)Co solutions standardized in RC POLATOM using previously validated methods.

  7. Unilateral whisker trimming in newborn rats alters neuronal coincident discharge among mature barrel cortex neurons.

    Science.gov (United States)

    Ghoshal, Ayan; Lustig, Brian; Popescu, Maria; Ebner, Ford; Pouget, Pierre

    2014-10-15

    It is known that sensory deprivation, including postnatal whisker trimming, can lead to severe deficits in the firing rate properties of cortical neurons. Recent results indicate that development of synchronous discharge among cortical neurons is also activity influenced, and that correlated discharge is significantly impaired following loss of bilateral sensory input in rats. Here we investigate whether unilateral whisker trimming (unilateral deprivation or UD) after birth interferes in the same way with the development of synchronous discharge in cortex. We measured the coincidence of spikes among pairs of neurons recorded under urethane anesthesia in one whisker barrel field deprived by trimming all contralateral whiskers for 60 days after birth (UD), and in untrimmed controls (CON). In the septal columns around barrels, UD significantly increased the coincident discharge among cortical neurons compared with CON, most notably in layers II/III. In contrast, synchronous discharge was normal between layer IV UD barrel neurons: i.e., not different from CON. Thus, while bilateral whisker deprivation (BD) produced a global deficit in the development of synchrony in layer IV, UD did not block the development of synchrony between neurons in layer IV barrels and increased synchrony within septal circuits. We conclude that changes in synchronous discharge after UD are unexpectedly different from those recorded after BD, and we speculate that this effect may be due to the driven activity from active commissural inputs arising from the contralateral hemisphere that received normal activity levels during postnatal development. Copyright © 2014 the American Physiological Society.

  8. Coincidence of calcified carotid atheromatous plaque, osteoporosis, and periodontal bone loss in dental panoramic radiographs

    Energy Technology Data Exchange (ETDEWEB)

    Ramesh, Aruna; Ganguly, Rumpa [Dept. of Diagnosis and Health Promotion, Division of Oral and Maxillofacial Radiology, Tufts University School of Dental Medicine, Boston (United States); Soroushian, Sheila [Dept. of Orthodontics, Howard University College of Dentistry, Washington, DC(United States)

    2013-12-15

    This study was performed to assess the correlation of calcified carotid atheromatous plaque (CCAP), the mandibular cortical index, and periodontal bone loss in panoramic radiographs. One hundred eighty-five panoramic radiographs with CCAP and 234 without this finding were evaluated by 3 observers for the presence of osseous changes related to osteoporosis and periodontal bone loss. Chi-squared and Mann-Whitney U tests were used to compare the two groups for an association of CCAP with the mandibular cortical index and periodontal bone loss, respectively. There was a statistically significant coincidence of CCAP and osseous changes related to osteopenia/osteoporosis, with a p-value <0.001. There was no statistically significant coincidence of CCAP and periodontal bone loss. When comparing the 2 groups, 'With CCAP' and 'Without CCAP', there was a statistically significant association with the mean body mass index (BMI), number of remaining teeth, positive history of diabetes mellitus, and vascular accidents. There was no statistically significant association with gender or a history of smoking. This study identified a possible concurrence of CCAP and mandibular cortical changes secondary to osteopenia/osteoporosis in panoramic radiographs. This could demonstrate the important role of dental professionals in screening for these systemic conditions, leading to timely and appropriate referrals resulting in early interventions and thus improving overall health.

  9. Performance of coincidence-based PSD on LiF/ZnS Detectors for Multiplicity Counting

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, Sean M.; Stave, Sean C.; Lintereur, Azaree; Siciliano, Edward R.; Cowles, Christian C.; Kouzes, Richard T.; Behling, Richard S.

    2016-10-06

    Abstract: Mass accountancy measurement is a nuclear nonproliferation application which utilizes coincidence and multiplicity counters to verify special nuclear material declarations. With a well-designed and efficient detector system, several relevant parameters of the material can be verified simultaneously. 6LiF/ZnS scintillating sheets may be used for this purpose due to a combination of high efficiency and short die-away times in systems designed with this material, but involve choices of detector geometry and exact material composition (e.g., the addition of Ni-quenching in the material) that must be optimized for the application. Multiplicity counting for verification of declared nuclear fuel mass involves neutron detection in conditions where several neutrons arrive in a short time window, with confounding gamma rays. This paper considers coincidence-based Pulse-Shape Discrimination (PSD) techniques developed to work under conditions of high pileup, and the performance of these algorithms with different detection materials. Simulated and real data from modern LiF/ZnS scintillator systems are evaluated with these techniques and the relationship between the performance under pileup and material characteristics (e.g., neutron peak width and total light collection efficiency) are determined, to allow for an optimal choice of detector and material.

  10. Classical signal model reproducing quantum probabilities for single and coincidence detections

    Science.gov (United States)

    Khrennikov, Andrei; Nilsson, Börje; Nordebo, Sven

    2012-05-01

    We present a simple classical (random) signal model reproducing Born's rule. The crucial point of our approach is that the presence of detector's threshold and calibration procedure have to be treated not as simply experimental technicalities, but as the basic counterparts of the theoretical model. We call this approach threshold signal detection model (TSD). The experiment on coincidence detection which was done by Grangier in 1986 [22] played a crucial role in rejection of (semi-)classical field models in favour of quantum mechanics (QM): impossibility to resolve the wave-particle duality in favour of a purely wave model. QM predicts that the relative probability of coincidence detection, the coefficient g(2) (0), is zero (for one photon states), but in (semi-)classical models g(2)(0) >= 1. In TSD the coefficient g(2)(0) decreases as 1/ɛ2d, where ɛd > 0 is the detection threshold. Hence, by increasing this threshold an experimenter can make the coefficient g(2) (0) essentially less than 1. The TSD-prediction can be tested experimentally in new Grangier type experiments presenting a detailed monitoring of dependence of the coefficient g(2)(0) on the detection threshold. Structurally our model has some similarity with the prequantum model of Grossing et al. Subquantum stochasticity is composed of the two counterparts: a stationary process in the space of internal degrees of freedom and the random walk type motion describing the temporal dynamics.

  11. Classical signal model reproducing quantum probabilities for single and coincidence detections

    CERN Document Server

    Khrennikov, Andrei; Nordebo, Sven

    2011-01-01

    We present a simple classical (random) signal model reproducing Born's rule. The crucial point of our approach is that the presence of detector's threshold and calibration procedure have to be treated not as simply experimental technicalities, but as the basic counterparts of the theoretical model. We call this approach threshold signal detection model (TSD). The experiment on coincidence detection which was done by Grangier in 1986 \\cite{Grangier} played a crucial role in rejection of (semi-)classical field models in favor of quantum mechanics (QM): impossibility to resolve the wave-particle duality in favor of a purely wave model. QM predicts that the relative probability of coincidence detection, the coefficient $g^{(2)}(0),$ is zero (for one photon states), but in (semi-)classical models $g^{(2)}(0)\\geq 1.$ In TSD the coefficient $g^{(2)}(0)$ decreases as $1/{\\cal E}_d^2,$ where ${\\cal E}_d>0$ is the detection threshold. Hence, by increasing this threshold an experimenter can make the coefficient $g^{(2)}...

  12. Ion-ion coincidence imaging at high event rate using an in-vacuum pixel detector

    Science.gov (United States)

    Long, Jingming; Furch, Federico J.; Durá, Judith; Tremsin, Anton S.; Vallerga, John; Schulz, Claus Peter; Rouzée, Arnaud; Vrakking, Marc J. J.

    2017-07-01

    A new ion-ion coincidence imaging spectrometer based on a pixelated complementary metal-oxide-semiconductor detector has been developed for the investigation of molecular ionization and fragmentation processes in strong laser fields. Used as a part of a velocity map imaging spectrometer, the detection system is comprised of a set of microchannel plates and a Timepix detector. A fast time-to-digital converter (TDC) is used to enhance the ion time-of-flight resolution by correlating timestamps registered separately by the Timepix detector and the TDC. In addition, sub-pixel spatial resolution (algorithm. This performance is achieved while retaining a high event rate (104 per s). The spectrometer was characterized and used in a proof-of-principle experiment on strong field dissociative double ionization of carbon dioxide molecules (CO2), using a 400 kHz repetition rate laser system. The experimental results demonstrate that the spectrometer can detect multiple ions in coincidence, making it a valuable tool for studying the fragmentation dynamics of molecules in strong laser fields.

  13. Algorithms for Identification of Nearly-Coincident Events in Calorimetric Sensors

    CERN Document Server

    Alpert, B; Bennett, D; Faverzani, M; Fowler, J; Giachero, A; Hays-Wehle, J; Maino, M; Nucciotti, A; Puiu, A; Swetz, D; Ullom, J

    2015-01-01

    For experiments with high arrival rates, reliable identification of nearly-coincident events can be crucial. For calorimetric measurements to directly measure the neutrino mass such as HOLMES, unidentified pulse pile-ups are expected to be a leading source of experimental error. Although Wiener filtering can be used to recognize pile-up, it suffers errors due to pulse-shape variation from detector nonlinearity, readout dependence on sub-sample arrival times, and stability issues from the ill-posed deconvolution problem of recovering Dirac delta-functions from smooth data. Due to these factors, we have developed a processing method that exploits singular value decomposition to (1) separate single-pulse records from piled-up records in training data and (2) construct a model of single-pulse records that accounts for varying pulse shape with amplitude, arrival time, and baseline level, suitable for detecting nearly-coincident events. We show that the resulting processing advances can reduce the required performa...

  14. ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand

    Directory of Open Access Journals (Sweden)

    Zhong Peng

    2015-10-01

    Full Text Available The regulation and mechanisms underlying itch sensation are complex. Here, we report a role for acid-sensing ion channel 3 (ASIC3 in mediating itch evoked by certain pruritogens during tissue acidosis. Co-administration of acid with Ser-Leu-Ile-Gly-Arg-Leu-NH2 (SL-NH2 increased scratching behavior in wild-type, but not ASIC3-null, mice, implicating the channel in coincident detection of acidosis and pruritogens. Mechanistically, SL-NH2 slowed desensitization of proton-evoked currents by targeting the previously identified nonproton ligand-sensing domain located in the extracellular region of ASIC3 channels in primary sensory neurons. Ablation of the ASIC3 gene reduced dry-skin-induced scratching behavior and pathological changes under conditions with concomitant inflammation. Taken together, our data suggest that ASIC3 mediates itch sensation via coincident detection of acidosis and nonproton ligands that act at the nonproton ligand-sensing domain of the channel.

  15. Design of a coincidence processing board for a dual-head PET scanner for breast imaging

    Energy Technology Data Exchange (ETDEWEB)

    Martinez, J.D. [Departamento de Ingenieria Electronica, University Politecnica de Valencia, Camino de Vera s/n 46022, Valencia (Spain)]. E-mail: jormarp1@doctor.upv.es; Toledo, J. [Departamento de Ingenieria Electronica, University Politecnica de Valencia, Camino de Vera s/n 46022, Valencia (Spain); Esteve, R. [Departamento de Ingenieria Electronica, University Politecnica de Valencia, Camino de Vera s/n 46022, Valencia (Spain); Sebastia, A. [Departamento de Ingenieria Electronica, University Politecnica de Valencia, Camino de Vera s/n 46022, Valencia (Spain); Mora, F.J. [Departamento de Ingenieria Electronica, University Politecnica de Valencia, Camino de Vera s/n 46022, Valencia (Spain); Benlloch, J.M. [Instituto de Fisica Corpuscular, CSIC-UV, Valencia (Spain); Fernandez, M.M. [Instituto de Fisica Corpuscular, CSIC-UV, Valencia (Spain); Gimenez, M. [Instituto de Fisica Corpuscular, CSIC-UV, Valencia (Spain); Gimenez, E.N. [Instituto de Fisica Corpuscular, CSIC-UV, Valencia (Spain); Lerche, Ch.W. [Instituto de Fisica Corpuscular, CSIC-UV, Valencia (Spain); Pavon, N. [Instituto de Fisica Corpuscular, CSIC-UV, Valencia (Spain); Sanchez, F. [Instituto de Fisica Corpuscular, CSIC-UV, Valencia (Spain)

    2005-07-01

    This paper describes the design of a coincidence processing board for a dual-head Positron Emission Tomography (PET) scanner for breast imaging. The proposed block-oriented data acquisition system relies on a high-speed DSP processor for fully digital trigger and on-line event processing that surpasses the performance of traditional analog coincidence detection systems. A mixed-signal board has been designed and manufactured. The analog section comprises 12 coaxial inputs (six per head) which are digitized by means of two 8-channel 12-bit 40-MHz ADCs in order to acquire the scintillation pulse, the charge division signals and the depth of interaction within the scintillator. At the digital section, a state-of-the-art FPGA is used as deserializer and also implements the DMA interface to the DSP processor by storing each digitized channel into a fast embedded FIFO memory. The system incorporates a high-speed USB 2.0 interface to the host computer.

  16. Sensitive neutron detection method using delayed coincidence transitions in existing iodine-containing detectors

    Science.gov (United States)

    Yakushev, E.; Rozov, S.; Drokhlyansky, A.; Filosofov, D.; Kalaninova, Z.; Timkin, V.; Ponomarev, D.

    2017-03-01

    This work explains a new, highly sensitive method for the detection of neutrons, which uses the T1/2 = 845 ns delay in the decay of 128I at the 137.8 keV energy level, resulting from the capture of thermal neutrons by iodine nuclei in NaI and CsI scintillation detectors. The use of delayed coincidence techniques with a several μs delay time window for delayed events allows for the highly effective discrimination of neutron events from any existing background signals. A comparison of ambient neutron measurements between those identified through the suggested method from a cylindrical, ø 63 mm × 63 mm NaI(Tl) scintillator and those from a low-background proportional 3He counter experimentally demonstrates the efficacy of this neutron detection method. For an isotropic, 4 π , thermal neutron flux of 1 ncm-2s-1 , the absolute sensitivity of the NaI detector was found to be 6.5 ± 1 countss-1 with an accidental coincidence background of 0.8 eventsday-1 for any delay time window of Δt = 1 μs . The proposed method can provide low-background experiments, using NaI or CsI, with measurements of the rate and stability of incoming neutron flux to a greater accuracy than 10-8 ncm-2s-1 .

  17. Zeldovich Lambda and Weinberg Relation: An Explanation for the Cosmological Coincidences

    CERN Document Server

    Alfonso-Faus, Antonio

    2008-01-01

    We prove that Zeldovich formula for the cosmological constant, in terms of the gravitational constant G, Plancks constant, and a fundamental particle mass m, is equivalent to the Weinberg relation. This one defines the mass m of a fundamental particle in terms of the same constants, G and h, plus the speed of light c and the Hubble parameter H. Then the speed of light c must be proportional to the Hubble parameter H. We explain the cosmological coincidences and finetuning problems that are puzzling the research in cosmology: We find that the gravitational radius of the Universe and its size are one and the same constant, from a cosmological point of view. Also the matter (energy) density of the Universe and the vacuum energy density are now, and have been always, of the same order of magnitude. We solve the coincidence problem and the cosmological constant problem. We decouple the cosmological constant concept from the vacuum energy concept. These results are achieved by the use of a cosmic Planck constant th...

  18. Rejection of randomly coinciding events in ZnMoO$_4$ scintillating bolometers

    CERN Document Server

    Chernyak, D M; Giuliani, A; Mancuso, M; Nones, C; Olivieri, E; Tenconi, M; Tretyak, V I

    2014-01-01

    Random coincidence of events (particularly from two neutrino double beta decay) could be one of the main sources of background in the search for neutrinoless double beta decay with cryogenic bolometers due to their poor time resolution. Pulse-shape discrimination by using front edge analysis, mean-time and $\\chi^2$ methods was applied to discriminate randomly coinciding events in ZnMoO$_4$ cryogenic scintillating bolometers. These events can be effectively rejected at the level of 99% by the analysis of the heat signals with rise-time of about 14 ms and signal-to-noise ratio of 900, and at the level of 92% by the analysis of the light signals with rise-time of about 3 ms and signal-to-noise ratio of 30, under the requirement to detect 95% of single events. These rejection efficiencies are compatible with extremely low background levels in the region of interest of neutrinoless double beta decay of $^{100}$Mo for enriched ZnMoO$_4$ detectors, of the order of $10^{-4}$ counts/(y keV kg). Pulse-shape parameters ...

  19. Off-Grid Radar Coincidence Imaging Based on Variational Sparse Bayesian Learning

    Directory of Open Access Journals (Sweden)

    Xiaoli Zhou

    2016-01-01

    Full Text Available Radar coincidence imaging (RCI is a high-resolution staring imaging technique motivated by classical optical coincidence imaging. In RCI, sparse reconstruction methods are commonly used to achieve better imaging result, while the performance guarantee is based on the general assumption that the scatterers are located at the prediscretized grid-cell centers. However, the widely existing off-grid problem degrades the RCI performance considerably. In this paper, an algorithm based on variational sparse Bayesian learning (VSBL is developed to solve the off-grid RCI. Applying Taylor expansion, the unknown true dictionary is approximated accurately to a linear model. Then target reconstruction is reformulated as a joint sparse recovery problem that recovers three groups of sparse coefficients over three known dictionaries with the constraint of the common support shared by the groups. VSBL is then applied to solve the problem by assigning appropriate priors to the three groups of coefficients. Results of numerical experiments demonstrate that the algorithm can achieve outstanding reconstruction performance and yield superior performance both in suppressing noise and in adapting to off-grid error.

  20. Correlation-Based Amplitude Estimation of Coincident Partials in Monaural Musical Signals

    Directory of Open Access Journals (Sweden)

    Jayme Garcia Arnal Barbedo

    2010-01-01

    Full Text Available This paper presents a method for estimating the amplitude of coincident partials generated by harmonic musical sources (instruments and vocals. It was developed as an alternative to the commonly used interpolation approach, which has several limitations in terms of performance and applicability. The strategy is based on the following observations: (a the parameters of partials vary with time; (b such a variation tends to be correlated when the partials belong to the same source; (c the presence of an interfering coincident partial reduces the correlation; and (d such a reduction is proportional to the relative amplitude of the interfering partial. Besides the improved accuracy, the proposed technique has other advantages over its predecessors: it works properly even if the sources have the same fundamental frequency, it is able to estimate the first partial (fundamental, which is not possible using the conventional interpolation method, it can estimate the amplitude of a given partial even if its neighbors suffer intense interference from other sources, it works properly under noisy conditions, and it is immune to intraframe permutation errors. Experimental results show that the strategy clearly outperforms the interpolation approach.

  1. Coincidences in analysis: Sigmund Freud and the strange case of Dr Forsyth and Herr von Vorsicht.

    Science.gov (United States)

    Pierri, Maria

    2010-08-01

    Freud's interest in thought transference opens the possibility for psychoanalytic research on the primary preverbal language and the maternal function, which the emphasis on verbal and paternal communication had hidden in the background of the setting. The author advances a new interpretation of coincidences in analysis and of the psychopathology of everyday life of the setting. Starting from a strange coincidence, new hypotheses are submitted following additional readings of the unpublished manuscript of the 'Forsyth case', recovered by the author, in regard to a significant moment of transformation, both in Freud and in psychoanalysis, at the end of the war. This phase corresponds first to a change of language, from German to English, as well as to the foundation of the International Journal of Psychoanalysis by Ernest Jones. In particular, the roots of the metapsychological turn of the 1920s are explored, together with the opening of private and productive thoughts in the area of 'telepathy' that joined Freud, Ferenczi, and Anna Freud in a true 'dialogue of unconsciouses'. The free association between A Child Is Being Beaten, Beyond the Pleasure Principle, and the clinical experience with 'Herr B.' is outlined in order to understand Freud's heroic self-analysis at the time when he was treating his daughter Anna and grieving the death of his beloved Sophie. Copyright © 2010 Institute of Psychoanalysis.

  2. Electron coincidence studies of sulfur-overlayers on Cu(001) and Ni(001) surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Di Filippo, G., E-mail: gianluca.filippo@fau.de [Max-Planck Institut für Mikrostrukturphysik, Weinberg 2, 06120 Halle (Germany); Schumann, F.O.; Patil, S.; Wei, Z. [Max-Planck Institut für Mikrostrukturphysik, Weinberg 2, 06120 Halle (Germany); Stefani, G. [CNISM and Dipartimento di Scienze, Università Roma Tre, Via della Vasca Navale 84, 00146 Rome (Italy); Fratesi, G. [Dipartimento di Fisica, Università degli Studi di Milano, Via Celoria 16, 20133 Milan (Italy); Trioni, M.I. [CNR – National Research Council of Italy, ISTM, Via Golgi 19, 20133 Milan (Italy); Kirschner, J. [Max-Planck Institut für Mikrostrukturphysik, Weinberg 2, 06120 Halle (Germany)

    2016-08-15

    Highlights: • The LVV Auger decay of different sulfur-overlayers is investigated. • The decay can be described within a two-step model. • The Auger line shapes furnish information on the electronic structure at the surface. • The e–e correlation energy is hardly affected by coverage or substrate variations. - Abstract: We have prepared different sulfur-overlayers on Cu(001) and Ni(001) surfaces which differ in their coverage and local environment of the S adatoms. Via photon absorption we excited the S 2p level and studied the subsequent Auger decay with a coincidence spectrometer. We discuss the variation of the coincidence rate as a function of the energy sum of the photo-Auger electron pair. This is linked to the binding energy of the double-hole state. We find that the photon energy has no dramatic influence on the spectra. Differences are observed when the local environment of sulfur is changed. The observed spectral changes are mainly ascribable to the variation of the density of states at the different surfaces. On the contrary, the strength of electron–electron correlation at the surface states is hardly affected by coverage or substrate variation.

  3. On Shannon’s Formula and Hartley’s Rule: Beyond the Mathematical Coincidence

    Directory of Open Access Journals (Sweden)

    Olivier Rioul

    2014-09-01

    Full Text Available In the information theory community, the following “historical” statements are generally well accepted: (1 Hartley did put forth his rule twenty years before Shannon; (2 Shannon’s formula as a fundamental tradeoff between transmission rate, bandwidth, and signal-to-noise ratio came out unexpected in 1948; (3 Hartley’s rule is inexact while Shannon’s formula is characteristic of the additive white Gaussian noise channel; (4 Hartley’s rule is an imprecise relation that is not an appropriate formula for the capacity of a communication channel. We show that all these four statements are somewhat wrong. In fact, a careful calculation shows that “Hartley’s rule” in fact coincides with Shannon’s formula. We explain this mathematical coincidence by deriving the necessary and sufficient conditions on an additive noise channel such that its capacity is given by Shannon’s formula and construct a sequence of such channels that makes the link between the uniform (Hartley and Gaussian (Shannon channels.

  4. Decay pathways after Xe 3d inner shell ionization using a multi-electron coincidence technique

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, I H; Nakano, M; Ito, K [Photon Factory, IMSS, KEK, Oho 1-1, Tsukuba, Ibaraki 305-0801 (Japan); Hikosaka, Y; Soejima, K [Department of Environmental Science, Niigata University, Niigata 950-2181 (Japan); Shigemasa, E [UVSOR Facility, Institute for Molecular Science, Okazaki, 444-8585 (Japan); Lablanquie, P; Penent, F [UPMC, Universite Paris 06, LCPMR, 11 rue de Pierre et Marie Curie, 75231 Paris Cedex 05 (France); Kouchi, N, E-mail: suzukii@post.kek.jp [Department of Chemistry, Tokyo Institute of Technology, O-okayama, Tokyo 152-8551 (Japan)

    2011-04-14

    Cascade Auger electron emission following Xe 3d photoionization has been investigated using a multi-electron coincidence technique, which utilizes an electron spectrometer of magnetic bottle type. It has been found that the Xe{sup 2+} states of the 4p{sup -1}4d{sup -1} configuration, formed by the Auger decay of the Xe{sup +} 3d{sub 3/2,5/2}{sup -1} states, dominantly turn into triply charged states of the 4d{sup -2}5p{sup -1}/4d{sup -2}5s{sup -1} configurations. The Xe{sup 2+} 4s{sup -1}4d{sup -1} states, formed by the 3d Auger decay, yield the 4p{sup -1}4d{sup -1}5p{sup -1} states as well as the 4d{sup -3} states. From the coincidence spectrum among three Auger electrons, it is suggested that the Xe{sup 2+} 4p{sup -1}4d{sup -1} states give rise to the following cascade processes: 4p{sup -1}4d{sup -1} {yields} 4d{sup -2}5p{sup -1} {yields} 4d{sup -1}5p{sup -3}.

  5. Development of Simultaneous Beta-and-Coincidence-Gamma Imager for Plant Imaging Research

    Energy Technology Data Exchange (ETDEWEB)

    Tai, Yuan-Chuan [Washington Univ., St. Louis, MO (United States). School of Medicine

    2016-09-30

    The goal of this project is to develop a novel imaging system that can simultaneously acquire beta and coincidence gamma images of positron sources in thin objects such as leaves of plants. This hybrid imager can be used to measure carbon assimilation in plants quantitatively and in real-time after C-11 labeled carbon-dioxide is administered. A better understanding of carbon assimilation, particularly under the increasingly elevated atmospheric CO2 level, is extremely critical for plant scientists who study food crop and biofuel production. Phase 1 of this project is focused on the technology development with 3 specific aims: (1) develop a hybrid detector that can detect beta and gamma rays simultaneously; (2) develop an imaging system that can differentiate these two types of radiation and acquire beta and coincidence gamma images in real-time; (3) develop techniques to quantify radiotracer distribution using beta and gamma images. Phase 2 of this project is to apply technologies developed in phase 1 to study plants using positron-emitting radionuclide such as 11C to study carbon assimilation in biofuel plants.

  6. A coincidence between a hydrocarbon plasma absorption spectrum and the lambda 5450 DIB

    CERN Document Server

    Linnartz, H; Van Winckel, H; Walker, G A H; Bohlender, D A; Tielens, A G G M; Motylewski, T; Maier, J P

    2010-01-01

    The aim of this work is to link the broad lambda 5450 diffuse interstellar band (DIB) to a laboratory spectrum recorded through an expanding acetylene plasma. Cavity ring-down direct absorption spectra and astronomical observations of HD 183143 with the HERMES spectrograph on the Mercator Telescope in La Palma and the McKellar spectrograph on the DAO 1.2 m Telescope are compared. In the 543-547 nm region a broad band is measured with a band maximum at 545 nm and FWHM of 1.03(0.1) nm coinciding with a well-known diffuse interstellar band at lambda 5450 with FWHM of 0.953 nm. A coincidence is found between the laboratory and the two independent observational studies obtained at higher spectral resolution. This result is important, as a match between a laboratory spectrum and a - potentially lifetime broadened - DIB is found. A series of additional experiments has been performed in order to unambiguously identify the laboratory carrier of this band. This has not been possible. The laboratory results, however, re...

  7. Microfluidic flow cytometer for quantifying photobleaching of fluorescent proteins in cells.

    Science.gov (United States)

    Lubbeck, Jennifer L; Dean, Kevin M; Ma, Hairong; Palmer, Amy E; Jimenez, Ralph

    2012-05-01

    Traditional flow cytometers are capable of rapid cellular assays on the basis of fluorescence intensity and light scatter. Microfluidic flow cytometers have largely followed the same path of technological development as their traditional counterparts; however, the significantly smaller transport distance and resulting lower cell speeds in microchannels provides for the opportunity to detect novel spectroscopic signatures based on multiple, nontemporally coincident excitation beams. Here, we characterize the design and operation of a cytometer with a three-beam, probe/bleach/probe geometry, employing HeLa suspension cells expressing fluorescent proteins. The data collection rate exceeds 20 cells/s under a range of beam intensities (5 kW to 179 kW/cm(2)). The measured percent photobleaching (ratio of fluorescence intensities excited by the first and third beams: S(beam3)/S(beam1)) partially resolves a mixture of four red fluorescent proteins in mixed samples. Photokinetic simulations are presented and demonstrate that the percent photobleaching reflects a combination of the reversible and irreversible photobleaching kinetics. By introducing a photobleaching optical signature, which complements traditional fluorescence intensity-based detection, this method adds another dimension to multichannel fluorescence cytometry and provides a means for flow-cytometry-based screening of directed libraries of fluorescent protein photobleaching.

  8. Fluorescence-Based Sensors

    Science.gov (United States)

    Orellana, Guillermo

    The natural luminescent phenomena (from the Latin words "lumen" and "essentia", i.e., "made of light") such as northern lights (aurora borealis), marine brightness, glow-worms, shining putrid fish scales, "bluish"- appearing water when contained in certain wooden cups (quinine fluorescence), some stones heated at high temperatures with reducing agents (BaS phosphorescence), or light emitted while crushing sugar (triboluminescence) already fascinated our ancestors. Nowadays we understand that ultraviolet and visible emission of light originates from a competitive deactivation pathway of the lowest electronic excited state of atoms and molecules that produces the so called luminescence (the sub-terms fluorescence and phosphorescence just designate whether the return of the excited to the ground state is an "allowed" or "forbidden" process, namely it is fast or slow, the loosely-defined border between them being a 1-μs-1 rate constant). Actually, luminescence is the only method to generate light in the known Universe regardless it is powered by the nuclear reactions in the stars, the ohmical heating in bulbs, an electric discharge, the absorption of light or a (bio)chemical reaction (chemiluminescence).

  9. The TALE Fluorescence Detectors

    Science.gov (United States)

    Jui, Charles

    2009-05-01

    The TALE fluorescence detectors are designed to extend the threshold for fluorescence observation by TA down to 3x10^16 eV. It will comprise two main components. The first is a set of 24 telescopes working in stereo, with an existing TA FD station at ˜6 km separation. These will cover between 3-31 degrees in elevation and have azimuthal coverage maximizing the stereo aperture in the 10^18-10^19 eV energy range. The second component consists of 15 telescopes equipped with 4m diameter mirrors and covering the sky between 31 and 73 degrees in elevation. The larger mirror size pushes the physics threshold down to 3x10^16 eV, and provides view of the shower maximum for the lower energy events. The Tower detector will cover one quadrant in azimuth and operate in hybrid mode with the TALE infill array to provide redundant composition measurements from both shower maximum information and muon-to-electron ratio.

  10. A fluorescence scanning electron microscope

    Directory of Open Access Journals (Sweden)

    Takaaki Kanemaru

    2010-01-01

    Full Text Available Fluorescence techniques are widely used in biological research to examine molecular localization, while electron microscopy can provide unique ultrastructural information. To date, correlative images from both fluorescence and electron microscopy have been obtained separately using two different instruments, i.e. a fluorescence microscope (FM and an electron microscope (EM. In the current study, a scanning electron microscope (SEM (JEOL JXA8600 M was combined with a fluorescence digital camera microscope unit and this hybrid instrument was named a fluorescence SEM (FL-SEM. In the labeling of FL-SEM samples, both Fluolid, which is an organic EL dye, and Alexa Fluor, were employed. We successfully demonstrated that the FL-SEM is a simple and practical tool for correlative fluorescence and electron microscopy.

  11. Fluorescence of ceramic color standards.

    Science.gov (United States)

    Koo, Annette; Clare, John F; Nield, Kathryn M; Deadman, Andrew; Usadi, Eric

    2010-04-20

    Fluorescence has been found in color standards available for use in calibration and verification of color measuring instruments. The fluorescence is excited at wavelengths below about 600?nm and emitted above 700?nm, within the response range of silicon photodiodes, but at the edge of the response of most photomultipliers and outside the range commonly scanned in commercial colorimeters. The degree of fluorescence on two of a set of 12 glossy ceramic tiles is enough to introduce significant error when those tiles have been calibrated in one mode of measurement and are used in another. We report the nature of the fluorescence and the implications for color measurement.

  12. Gross Motor Coincidence Timing by Children with Learning Difficulties and Children Matched on Mean Chronological and Mental Age.

    Science.gov (United States)

    Jacklin, Susan M.

    1987-01-01

    This study examines the learning of a gross motor coincidence timing task by children with learning difficulties, compared with that by children of average intelligence of an equivalent chronological age and mental age. Results are discussed. (Author/MT)

  13. Financial market implications of monetary policy coincidences: Evidence from the UK and Euro Area government-bond markets

    OpenAIRE

    Arestis, Philip; Phelps, P.

    2017-01-01

    Relatively little is known about the financial market impact of international monetary surprises arising on the same trading day. This paper estimates a suite of multi-security factor models, which captures international monetary surprise effects on UK and Euro Area government-bond markets over the period 1999–2014. In doing so, we shed light on the relative importance of coinciding, non-coinciding monetary surprises and non-monetary surprises across the yield curve. We find some support for ...

  14. Fluorescence dynamics of green fluorescent protein in AOT reversed micelles

    NARCIS (Netherlands)

    Uskova, M.A.; Borst, J.W.; Hink, M.A.; Hoek, van A.; Schots, A.; Klyachko, N.L.; Visser, A.J.W.G.

    2000-01-01

    We have used the enhanced green fluorescent protein (EGFP) to investigate the properties of surfactant-entrapped water pools in organic solvents (reversed micelles) with steady-state and time-resolved fluorescence methods. The surfactant used was sodium bis(2-ethylhexyl)sulfosuccinate (AOT) and the

  15. Analysis of the effect of true coincidence summing on efficiency calibration for an HP GE detector

    Energy Technology Data Exchange (ETDEWEB)

    Rodenas, J.; Gallardo, S.; Ballester, S.; Primault, V. [Valencia Univ. Politecnica, Dept. de Ingenieria Quimica y Nuclear (Spain); Ortiz, J. [Valencia Univ. Politecnica, Lab. de Radiactividad Ambiental (Spain)

    2006-07-01

    The H.P. (High Purity) Germanium detector is commonly used for gamma spectrometry in environmental radioactivity laboratories. The efficiency of the detector must be calibrated for each geometry considered. This calibration is performed using a standard solution containing gamma emitter sources. The usual goal is the obtaining of an efficiency curve to be used in the determination of the activity of samples with the same geometry. It is evident the importance of the detector calibration. However, the procedure presents some problems as it depends on the source geometry (shape, volume, distance to detector, etc.) and shall be repeated when these factors change. That means an increasing use of standard solutions and consequently an increasing generation of radioactive wastes. Simulation of the calibration procedure with a validated computer program is clearly an important auxiliary tool for environmental radioactivity laboratories. This simulation is useful for both optimising calibration procedures and reducing the amount of radioactivity wastes produced. The M.C.N.P. code, based on the Monte Carlo method, has been used in this work for the simulation of detector calibration. A model has been developed for the detector as well as for the source contained in a Petri box. The source is a standard solution that contains the following radionuclides: {sup 241}Am, {sup 109}Cd, {sup 57}Co, {sup 139}Ce, {sup 203}Hg, {sup 113}Sn, {sup 85}Sr, {sup 137}Cs, {sup 88}Y and {sup 60}Co; covering a wide energy range (50 to 2000 keV). However, there are two radionuclides in the solution ({sup 60}Co and {sup 88}Y) that emit gamma rays in true coincidence. The effect of the true coincidence summing produces a distortion of the calibration curve at higher energies. To decrease this effect some measurements have been performed at increasing distances between the source and the detector. As the true coincidence effect is observed in experimental measurements but not in the Monte Carlo

  16. Effects of Calcium Spikes in the Layer 5 Pyramidal Neuron on Coincidence Detection and Activity Propagation.

    Science.gov (United States)

    Chua, Yansong; Morrison, Abigail

    2016-01-01

    The role of dendritic spiking mechanisms in neural processing is so far poorly understood. To investigate the role of calcium spikes in the functional properties of the single neuron and recurrent networks, we investigated a three compartment neuron model of the layer 5 pyramidal neuron with calcium dynamics in the distal compartment. By performing single neuron simulations with noisy synaptic input and occasional large coincident input at either just the distal compartment or at both somatic and distal compartments, we show that the presence of calcium spikes confers a substantial advantage for coincidence detection in the former case and a lesser advantage in the latter. We further show that the experimentally observed critical frequency phenomenon, in which action potentials triggered by stimuli near the soma above a certain frequency trigger a calcium spike at distal dendrites, leading to further somatic depolarization, is not exhibited by a neuron receiving realistically noisy synaptic input, and so is unlikely to be a necessary component of coincidence detection. We next investigate the effect of calcium spikes in propagation of spiking activities in a feed-forward network (FFN) embedded in a balanced recurrent network. The excitatory neurons in the network are again connected to either just the distal, or both somatic and distal compartments. With purely distal connectivity, activity propagation is stable and distinguishable for a large range of recurrent synaptic strengths if the feed-forward connections are sufficiently strong, but propagation does not occur in the absence of calcium spikes. When connections are made to both the somatic and the distal compartments, activity propagation is achieved for neurons with active calcium dynamics at a much smaller number of neurons per pool, compared to a network of passive neurons, but quickly becomes unstable as the strength of recurrent synapses increases. Activity propagation at higher scaling factors can be

  17. Coincidence and coherent data analysis methods for gravitational wave bursts in a network of interferometric detectors

    Science.gov (United States)

    Arnaud, Nicolas; Barsuglia, Matteo; Bizouard, Marie-Anne; Brisson, Violette; Cavalier, Fabien; Davier, Michel; Hello, Patrice; Kreckelbergh, Stephane; Porter, Edward K.

    2003-11-01

    Network data analysis methods are the only way to properly separate real gravitational wave (GW) transient events from detector noise. They can be divided into two generic classes: the coincidence method and the coherent analysis. The former uses lists of selected events provided by each interferometer belonging to the network and tries to correlate them in time to identify a physical signal. Instead of this binary treatment of detector outputs (signal present or absent), the latter method involves first the merging of the interferometer data and looks for a common pattern, consistent with an assumed GW waveform and a given source location in the sky. The thresholds are only applied later, to validate or not the hypothesis made. As coherent algorithms use more complete information than coincidence methods, they are expected to provide better detection performances, but at a higher computational cost. An efficient filter must yield a good compromise between a low false alarm rate (hence triggering on data at a manageable rate) and a high detection efficiency. Therefore, the comparison of the two approaches is achieved using so-called receiving operating characteristics (ROC), giving the relationship between the false alarm rate and the detection efficiency for a given method. This paper investigates this question via Monte Carlo simulations, using the network model developed in a previous article. Its main conclusions are the following. First, a three-interferometer network such as Virgo-LIGO is found to be too small to reach good detection efficiencies at low false alarm rates: larger configurations are suitable to reach a confidence level high enough to validate as true GW a detected event. In addition, an efficient network must contain interferometers with comparable sensitivities: studying the three-interferometer LIGO network shows that the 2-km interferometer with half sensitivity leads to a strong reduction of performances as compared to a network of three

  18. Polarisation-based coincidence event discrimination: an in silico study towards a feasible scheme for Compton-PET

    Science.gov (United States)

    Toghyani, M.; Gillam, J. E.; McNamara, A. L.; Kuncic, Z.

    2016-08-01

    Current positron emission tomography (PET) systems use temporally localised coincidence events discriminated by energy and time-of-flight information. The two annihilation photons are in an entangled polarisation state and, in principle, additional information from the polarisation correlation of photon pairs could be used to improve the accuracy of coincidence classification. In a previous study, we demonstrated that in principle, the polarisation correlation information could be transferred to an angular correlation in the distribution of scattered photon pairs in a planar Compton camera system. In the present study, we model a source-phantom-detector system using Geant4 and we develop a coincidence classification scheme that exploits the angular correlation of scattered annihilation quanta to improve the accuracy of coincidence detection. We find a 22% image quality improvement in terms of the peak signal-to-noise ratio when scattered coincidence events are discriminated solely by their angular correlation, thus demonstrating the feasibility of this novel classification scheme. By integrating scatter events (both single-single and single-only) with unscattered coincidence events discriminated using conventional methods, our results suggest that Compton-PET may be a promising candidate for optimal emission tomographic imaging.

  19. Standardization of {sup 59}Fe 4πβ(LS)-γcoincidence counting with digital sampling method

    Energy Technology Data Exchange (ETDEWEB)

    Agusbudiman, A.; Lee, K. B.; Lee, J. M.; Park, T. S. [Korea University of Science and Technology (UST), Daejeon (Korea, Republic of)

    2014-11-15

    The radionuclide 59Fe decays with a half-life of 44.494(12) days, by several beta minus emission to the ground state and to four excited states of {sup 59}Co, mainly to the 1099 keV and 1291 keV (Bé et al., 2004). The activity of {sup 59}Fe was measured by 4 πβ(LS)-γ coincidence counting method with digital sampling technique. A gamma spectrometry analysis was also conducted to check the impurities of the source. As comparison, the activity were also measured by using the 4πβ(PC)-γ coincidence counting system and 4πβ (LS)-γ anti-coincidence method. The radionuclide 59Fe has been standardized using the 4πβ(LS)-γcoincidence counting with digital sampling method. The result was in a good agreement with the result from 4πβ(PC)-γ coincidence counting and the 4πβ(LS)-γ anti-coincidence method.

  20. Characterizations of double pulsing in neutron multiplicity and coincidence counting systems

    Science.gov (United States)

    Koehler, Katrina E.; Henzl, Vladimir; Croft, Stephen S.; Henzlova, Daniela; Santi, Peter A.

    2016-10-01

    Passive neutron coincidence/multiplicity counters are subject to non-ideal behavior, such as double pulsing and dead time. It has been shown in the past that double-pulsing exhibits a distinct signature in a Rossi-alpha distribution, which is not readily noticed using traditional Multiplicity Shift Register analysis. However, it has been assumed that the use of a pre-delay in shift register analysis removes any effects of double pulsing. In this work, we use high-fidelity simulations accompanied by experimental measurements to study the effects of double pulsing on multiplicity rates. By exploiting the information from the double pulsing signature peak observable in the Rossi-alpha distribution, the double pulsing fraction can be determined. Algebraic correction factors for the multiplicity rates in terms of the double pulsing fraction have been developed. We discuss the role of these corrections across a range of scenarios.

  1. Energy and coincidence time resolution measurements of CdTe detectors for PET

    Science.gov (United States)

    Ariño, G.; Chmeissani, M.; De Lorenzo, G.; Puigdengoles, C.; Cabruja, E.; Calderón, Y.; Kolstein, M.; Macias-Montero, J. G.; Martinez, R.; Mikhaylova, E.; Uzun, D.

    2013-02-01

    We report on the characterization of 2 mm thick CdTe diode detector with Schottky contacts to be employed in a novel conceptual design of PET scanner. Results at -8°C with an applied bias voltage of -1000 V/mm show a 1.2% FWHM energy resolution at 511 keV. Coincidence time resolution has been measured by triggering on the preamplifier output signal to improve the timing resolution of the detector. Results at the same bias and temperature conditions show a FWHM of 6 ns with a minimum acceptance energy of 500 keV. These results show that pixelated CdTe Schottky diode is an excellent candidate for the development of next generation nuclear medical imaging devices such as PET, Compton gamma cameras, and especially PET-MRI hybrid systems when used in a magnetic field immune configuration.

  2. Electron-ion coincidence spectrometer for studies on decay dynamics of core-excited molecules

    Energy Technology Data Exchange (ETDEWEB)

    Kaneyasu, T. [UVSOR Facility, Institute for Molecular Science, Nishigonaka 38, Myodaiji, Okazaki 444-8585 (Japan)], E-mail: kaneyasu@ims.ac.jp; Hikosaka, Y.; Shigemasa, E. [UVSOR Facility, Institute for Molecular Science, Nishigonaka 38, Myodaiji, Okazaki 444-8585 (Japan)

    2007-05-15

    We have developed an Auger electron-ion coincidence spectrometer to measure energy- and angular-correlations among the particles ejected on decay of core-excited/ionized molecules. The apparatus consists of a double toroidal electron analyzer and a three-dimensional ion momentum spectrometer, both of which are terminated by time- and position-sensitive detectors. For extracting the ions into the ion momentum spectrometer, a pulsed electric field is applied to the interaction region, according to each Auger electron observation. To evaluate the performance of the ion momentum spectrometer, momentum vectors of fragment ions produced through the dissociation from the selected molecular ion states following N{sub 2} core photoionization have been observed. The momentum, energy and angular resolutions achieved by the spectrometer have been estimated from the events associated with the formation of N{sub 2}{sup 2+} and with the pair formation of N{sup +}+{sup N+}.

  3. Growth of coincident site lattice matched semiconductor layers and devices on crystalline substrates

    Science.gov (United States)

    Norman, Andrew G; Ptak, Aaron J

    2013-08-13

    Methods of fabricating a semiconductor layer or device and said devices are disclosed. The methods include but are not limited to providing a substrate having a crystalline surface with a known lattice parameter (a). The method further includes growing a crystalline semiconductor layer on the crystalline substrate surface by coincident site lattice matched epitaxy, without any buffer layer between the crystalline semiconductor layer and the crystalline surface of the substrate. The crystalline semiconductor layer will be prepared to have a lattice parameter (a') that is related to the substrate lattice parameter (a). The lattice parameter (a') maybe related to the lattice parameter (a) by a scaling factor derived from a geometric relationship between the respective crystal lattices.

  4. High mass-resolution electron-ion-ion coincidence measurements on core-excited organic molecules

    CERN Document Server

    Tokushima, T; Senba, Y; Yoshida, H; Hiraya, A

    2001-01-01

    Total electron-ion-ion coincidence measurements on core excited organic molecules have been carried out with high mass resolution by using multimode (reflectron/linear) time-of-flight mass analyzer. From the ion correlation spectra of core excited CH sub 3 OH and CD sub 3 OH, the reaction pathway to form H sub 3 sup + (D sub 3 sup +) is identified as the elimination of three H (D) atoms from the methyl group, not as the inter-group (-CH sub 3 and -OH) interactions. In a PEPIPICO spectrum of acetylacetone (CH sub 3 COCH sub 2 COCH sub 3) measured by using a reflectron TOF, correlations between ions up to mass number 70 with one-mass resolution was recorded.

  5. Performance of the Anti-Coincidence Detector on the GLAST Large Area Telescope

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, D.J.; /NASA, Goddard; Charles, E.; /SLAC; Hartman, R.C.; /NASA, Goddard; Moiseev, A.A.; /NASA, Goddard; Ormes, J.F.; /NASA, Goddard /Denver U.

    2007-10-22

    The Anti-Coincidence Detector (ACD), the outermost detector layer in the Gamma-ray Large Area Space Telescope (GLAST) Large Area Telescope (LAT), is designed to detect and veto incident cosmic ray charged particles, which outnumber cosmic gamma rays by 3-4 orders of magnitude. The challenge in ACD design is that it must have high (0.9997) detection efficiency for singly-charged relativistic particles, but must also have a low probability for self-veto of high-energy gammas by backsplash radiation from interactions in the LAT calorimeter. Simulations and tests demonstrate that the ACD meets its design requirements. The performance of the ACD has remained stable through stand-alone environmental testing, shipment across the U.S., installation onto the LAT, shipment back across the U.S., LAT environmental testing, and shipment to Arizona. As part of the fully-assembled GLAST observatory, the ACD is being readied for final testing before launch.

  6. Do climate extreme events foster violent civil conflicts? A coincidence analysis

    Science.gov (United States)

    Schleussner, Carl-Friedrich; Donges, Jonathan F.; Donner, Reik V.

    2014-05-01

    Civil conflicts promoted by adverse environmental conditions represent one of the most important potential feedbacks in the global socio-environmental nexus. While the role of climate extremes as a triggering factor is often discussed, no consensus is yet reached about the cause-and-effect relation in the observed data record. Here we present results of a rigorous statistical coincidence analysis based on the Munich Re Inc. extreme events database and the Uppsala conflict data program. We report evidence for statistically significant synchronicity between climate extremes with high economic impact and violent conflicts for various regions, although no coherent global signal emerges from our analysis. Our results indicate the importance of regional vulnerability and might aid to identify hot-spot regions for potential climate-triggered violent social conflicts.

  7. Cessation of feline calicivirus shedding coincident with resolution of chronic gingivostomatitis in a cat.

    Science.gov (United States)

    Addie, D D; Radford, A; Yam, P S; Taylor, D J

    2003-04-01

    Feline calicivirus (FCV) shedding and oral bacterial flora were monitored over a period of 22 months in a case of feline gingivostomatitis (FGS). The cat was treated daily with 50 mg thalidomide capsules by mouth, and 200 mg lactoferrin powder was applied directly to the lesions. Clinical signs began to resolve after 11 months when, in addition to treatment, the diet had been changed to an additive-free cat food supplemented with antioxidant vitamins A, D3 and E. Resolution of clinical signs of FGS coincided with the cessation of FCV shedding, and this is the first report documenting such an association. Which part of the treatment, if any, contributed to the cure requires further investigation.

  8. Coincidence detection of spatially correlated photon pairs with a monolithic time-resolving detector array

    CERN Document Server

    Unternährer, Manuel; Gasparini, Leonardo; Stoppa, David; Stefanov, André

    2016-01-01

    We demonstrate coincidence measurements of spatially entangled photons by means of a novel type of multi-pixel based detection array. The adopted sensor is a fully digital 8$\\times$16 silicon photomultiplier array allowing not only photon counting but also per-pixel time stamping of the arrived photons with a resolution of 65 ps. Together with a frame rate of 500 kfps, this property exceeds the capabilities of conventional charge-coupled device cameras which have become of growing interest for the detection of transversely correlated photon pairs. The sensor is used to measure a second-order correlation function for various non-collinear configurations of entangled photons generated by spontaneous parametric down-conversion. The experimental results are compared to theory.

  9. γ-Particle coincidence technique for the study of nuclear reactions

    Energy Technology Data Exchange (ETDEWEB)

    Zagatto, V.A.B., E-mail: vinicius.zagatto@gmail.com [Instituto de Física da Universidade de São Paulo (Brazil); Oliveira, J.R.B.; Allegro, P.R.P.; Chamon, L.C.; Cybulska, E.W.; Medina, N.H.; Ribas, R.V.; Seale, W.A.; Silva, C.P.; Gasques, L.R. [Instituto de Física da Universidade de São Paulo (Brazil); Zahn, G.S.; Genezini, F.A.; Shorto, J.M.B. [Instituto de Pesquisas Energéticas e Nucleares (Brazil); Lubian, J.; Linares, R. [Instituto de Física da Universidade Federal Fluminense (Brazil); Toufen, D.L. [Instituto Federal de Educação, Ciência e Tecnologia (Brazil); Silveira, M.A.G. [Centro Universitário da FEI (Brazil); Rossi, E.S. [Centro Universitário FIEO – UNIFIEO (Brazil); Nobre, G.P. [Lawrence Livermore National Laboratory (United States)

    2014-06-01

    The Saci-Perere γ ray spectrometer (located at the Pelletron AcceleratorLaboratory – IFUSP) was employed to implement the γ-particle coincidence technique for the study of nuclear reaction mechanisms. For this, the {sup 18}O+{sup 110}Pd reaction has been studied in the beam energy range of 45–54 MeV. Several corrections to the data due to various effects (energy and angle integrations, beam spot size, γ detector finite size and the vacuum de-alignment) are small and well controlled. The aim of this work was to establish a proper method to analyze the data and identify the reaction mechanisms involved. To achieve this goal the inelastic scattering to the first excited state of {sup 110}Pd has been extracted and compared to coupled channel calculations using the São Paulo Potential (PSP), being reasonably well described by it.

  10. Attochirp-corrected photo ionization time delays using coincidence attosecond streaking

    CERN Document Server

    Sabbar, M; Boge, R; Lucchini, M; Gallmann, L; Cirelli, C; Keller, U

    2014-01-01

    Recent measurements have demonstrated the possibility of probing single-photon ionization time delays of electrons originating from different initial states [1,2]. Here, we show for the first time the importance of the temporal structure of the ionizing single attosecond pulse (i.e. attochirp) in the extraction of time delays in attosecond streaking experiments. We have demonstrated this by measuring the time delay between valence electrons from different atomic species by combining attosecond streaking with a coincidence detection scheme. This novel technique allows for the simultaneous measurement of both species under identical conditions. We find that the attochirp introduces an artificial time delay that may exceed the atomic time delay and present a general procedure, which corrects for this contribution. Our analysis, exemplarily applied to argon (Ar) and neon (Ne), reveals an energy-dependent atomic time delay of a few tens of attoseconds in agreement with theoretical predictions.

  11. The Accelerator Neutrino Neutron Interaction Experiment (ANNIE) Front Anti-Coincidence Counter (FACC) Testing

    Science.gov (United States)

    Chen, Mingqian

    The searching for proton decay (PDK) is going on current Water Cherenkov (WCh) detectors such as Super-Kamiokande. However, PDK-like backgrounds produced by the neutrino interactions will limit the sensitivity of the detectors. The Accelerator Neutrino Neutron Interaction Experiment (ANNIE) is going to measure the neutron yield of neutrino interactions in gadolinium-loaded water by the Booster Neutrino Beam (BNB) with known characteristics. In this thesis, neutrino, neutrino oscillations, Dirac neutrino and Majorana neutrino and neutrino interactions are introduced. ANNIE experiment is also introduced. And two modes of proton decays are discussed. The ANNIE experiment requires detection of the neutrons produced by the BNB interactions with water. However, dirt muons produced by the interaction of the BNB with the rock and dirt upstream of the ANNIE hall will cause a correlated background. Therefore, the Front Anti-Coincidence Counter (FACC) was built to measure the rock muons. This thesis details the design, installation, and commissioning of the ANNIE FACC.

  12. Observation of autoionization in O 2 by an electron-electron coincidence method

    Science.gov (United States)

    Doering, J. P.; Yang, J.; Cooper, J. W.

    1995-01-01

    A strong transition to an autoionizing stata has been observed in O 2 at 16.83 ± 0.11 eV by means of a new electron-electron conincidence method. The method uses the fact that electrons arising from autoionizing states appear at a constant energy loss corresponding to the excitation energy of the autoionizing state rather than at a constant ionization potential as do electrons produced by direct ionization. Comparison of the present data with previous photoionization studies suggests that the autoionizing O 2 state is the same state deduced to be responsible for abnormal vibrational intensities in the O 2+X 2Πg ground state when 16.85 eV Ne(I) photons are used. These electron-electron coincidence experiments provide a direct new method for the study of autoionization produced by electron impact.

  13. Field test and evaluation of the passive neutron coincidence collar for prototype fast reactor fuel subassemblies

    Energy Technology Data Exchange (ETDEWEB)

    Menlove, H.O.; Keddar, A.

    1982-08-01

    The passive neutron Coincidence Collar, which was developed for the verification of plutonium content in fast reactor fuel subassemblies, has been field tested using Prototype Fast Reactor fuel. For passive applications, the system measures the /sup 240/Pu-effective mass from the spontaneous fission rate, and in addition, a self-interrogation technique is used to determine the fissile content in the subassembly. Both the passive and active modes were evaluated at the Windscale Works in the United Kingdom. The results of the tests gave a standard deviation 0.75% for the passive count and 3 to 7% for the active measurement for a 1000-s counting time. The unit will be used in the future for the verification of plutonium in fresh fuel assemblies.

  14. Coincidence, historical repetition, and self-knowledge: Jung, Vico, and Joyce.

    Science.gov (United States)

    Verene, Donald Phillip

    2002-07-01

    Jung develops synchronicity as an a causal principle of connection by recounting various examples of meaningful coincidence from experience and by analysing various systems of divination, notably the I Ching. Philosophical theory of causality has given no significant attention to synchronicity; the events of synchronicity are regarded as chance. The Neapolitan philosopher Giambattista Vico (1668-1744) developed a doctrine of historical experience and of self-knowledge that grounds the phenomenon of synchronicity in a metaphysics. James Joyce employed Vico's conception of language and historical cycles as the basis of Joyce's final literary work, Finnegans Wake. Vico's metaphysical sense of synchronicity and Joyce's literary formulation offer a grounding of this principle in non-divinatory sources in modern Western thought, something which Jung's discussion does not provide. These philosophical and literary perspectives complement Jung's to offer an expanded context in which to recognize synchronicity and to make sense of it.

  15. New approach to the kinematic coincidence method in heavy ion reactions

    Energy Technology Data Exchange (ETDEWEB)

    Casini, G.; Maurenzig, P.R.; Olmi, A.; Stefanini, A.A.

    1989-05-01

    A new approach to the kinematic coincidence method (KCM) is proposed, which makes use of the whole kinematic information of heavy ion experiments in a self-consistent way. It takes advantage of the overdetermination of the measurement yielding not only solutions for the primary masses of the fragments, but also 'improved values' for their velocity vectors. A statistical variable, ..delta../sub v/, indicates to what extent the secondary quantities violate the kinematics of the reaction. The ability of the present approach to reproduce the primary quantities of a binary or ternary reaction is compared with that of older approaches on the basis of realistic Monte Carlo simulations. The background of incompletely detected events of higher multiplicity can be effectively subtracted using the results of the present analysis.

  16. A new approach to the kinematic coincidence method in heavy ion reactions

    Science.gov (United States)

    Casini, G.; Maurenzig, P. R.; Olmi, A.; Stefanini, A. A.

    1989-05-01

    A new approach to the kinematic coincidence method (KCM) is proposed, which makes use of the whole kinematic information of heavy ion experiments in a self-consistent way. It takes advantage of the overdetermination of the measurement yielding not only solutions for the primary masses of the fragments, but also "improved values" for their velocity vectors. A statistical variable, Δν, indicates to what extent the secondary quantities violate the kinematics of the reaction. The ability of the present approach to reproduce the primary quantities of a binary or ternary reaction is compared with that of older approaches on the basis of realistic Monte Carlo simulations. The background of incompletely detected events of higher multiplicity can be effectively subtracted using the results of the present analysis.

  17. The Anti-Coincidence Detector for the GLAST Large Area Telescope

    Energy Technology Data Exchange (ETDEWEB)

    Moiseev, A.A.; Hartman, R.C.; Ormes, J.F.; Thompson, D.J.; Amato, M.J.; Johnson, T.E.; Segal, K.N.; Sheppard, D.A.

    2007-03-23

    This paper describes the design, fabrication and testing of the Anti-Coincidence Detector (ACD) for the Gamma-ray Large Area Space Telescope (GLAST) Large Area Telescope (LAT). The ACD is LAT's first-level defense against the charged cosmic ray background that outnumbers the gamma rays by 3-5 orders of magnitude. The ACD covers the top and 4 sides of the LAT tracking detector, requiring a total active area of {approx}8.3 square meters. The ACD detector utilizes plastic scintillator tiles with wave-length shifting fiber readout. In order to suppress self-veto by shower particles at high gamma-ray energies, the ACD is segmented into 89 tiles of different sizes. The overall ACD efficiency for detection of singly charged relativistic particles entering the tracking detector from the top or sides of the LAT exceeds the required 0.9997.

  18. On the precipitation sequence in a Ni-based superalloy: A Coincidence Doppler Broadening study

    Energy Technology Data Exchange (ETDEWEB)

    Macchi, C.E. [IFIMAT, UNCentro and CONICET, Pinto 399, B7000GHG Tandil (Argentina); Somoza, A. [IFIMAT, UNCentro and CICPBA, Pinto 399, B7000GHG Tandil (Argentina); Santos, G. [NIECyT, UNCentro, Pinto 399, B7000GHG Tandil (Argentina); Petkov, M. [Jet Propulsion Lab, California Institute of Technology, Pasadena, CA 91109 (United States); Lynn, K.G. [Department of Physics, Washington State University, Pullman WA 99164-2814 (United States)

    2007-07-01

    The precipitation sequence at 700 C of the Ni{sub 3}(Ti,Al)-type ordered {gamma}' phase in the commercial nickel-based superalloy Inconel X-750 was investigated using Coincidence Doppler Broadening (CDB) technique. The results obtained are discussed in terms of positron annihilation in two well-defined states: one corresponding to the matrix ({gamma} phase) and a second related to the {gamma}' precipitates. Between these two aging stages, CDB distributions corresponding to selected intermediate aging treatments could be presented exactly, within the experimental scatter, as a linear combination of the {gamma} and {gamma}' signatures. (copyright 2007 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  19. Reduction of elevated IGF-1 levels in coincident amyotrophic lateral sclerosis and acromegaly.

    Science.gov (United States)

    Pereira, Erlick A C; Turner, Martin R; Wass, John A H; Talbot, Kevin

    2010-01-01

    We report a patient presenting with ALS in whom acromegaly was later confirmed. Insulin-like growth factor-1 (IGF-1) has been tried in the treatment of ALS and despite equivocal results from clinical trials, efforts have continued to try to harness the significant positive effects on motor neuron growth observed in vitro and in survival of mouse models of the disease. One subsequent study has reported an association between higher circulating serum IGF-1 levels and longer disease duration in ALS patients. Concern therefore arose in our case that treatment of the acromegaly with a somatostatin analogue might adversely affect the natural course of his ALS through lowering of potentially beneficial IGF-1 levels. Through clinical observation and prognostic modelling we suggest that this concern was unfounded. The potential interaction of these two rarely coincident disorders in our patient is discussed.

  20. Catalyzing Transdisciplinarity: A Systems Ethnography of Cancer-Obesity Comorbidity and Risk Coincidence.

    Science.gov (United States)

    Graham, S Scott; Harley, Amy; Kessler, Molly M; Roberts, Laura; DeVasto, Dannielle; Card, Daniel J; Neuner, Joan M; Kim, Sang-Yeon

    2017-05-01

    Effectively addressing wicked health problems, that is, those arising from complex multifactorial biological and socio-economic causes, requires transdisciplinary action. However, a significant body of research points toward substantial difficulties in cultivating transdisciplinary collaboration. Accordingly, this article presents the results of a study that adapts Systems Ethnography and Qualitative Modeling (SEQM) in response to wicked health problems. SEQM protocols were designed to catalyze transdisciplinary responses to national defense concerns. We adapted these protocols to address cancer-obesity comorbidity and risk coincidence. In so doing, we conducted participant-observations and interviews with a diverse range of health care providers, community health educators, and health advocacy professionals who target either cancer or obesity. We then convened a transdisciplinary conference designed to catalyze a coordinated response. The findings offer productive insights into effective ways of catalyzing transdisciplinarity in addressing wicked health problems action and demonstrate the promise of SEQM for continued use in health care contexts.

  1. Subducting slab ultra-slow velocity layer coincident with silent earthquakes in southern Mexico.

    Science.gov (United States)

    Song, Teh-Ru Alex; Helmberger, Donald V; Brudzinski, Michael R; Clayton, Robert W; Davis, Paul; Pérez-Campos, Xyoli; Singh, Shri K

    2009-04-24

    Great earthquakes have repeatedly occurred on the plate interface in a few shallow-dipping subduction zones where the subducting and overriding plates are strongly locked. Silent earthquakes (or slow slip events) were recently discovered at the down-dip extension of the locked zone and interact with the earthquake cycle. Here, we show that locally observed converted SP arrivals and teleseismic underside reflections that sample the top of the subducting plate in southern Mexico reveal that the ultra-slow velocity layer (USL) varies spatially (3 to 5 kilometers, with an S-wave velocity of approximately 2.0 to 2.7 kilometers per second). Most slow slip patches coincide with the presence of the USL, and they are bounded by the absence of the USL. The extent of the USL delineates the zone of transitional frictional behavior.

  2. The underwater coincidence counter for plutonium measurements in mixed-oxide fuel assemblies manual

    Energy Technology Data Exchange (ETDEWEB)

    G. W. Eccleston; H. O. Menlove; M. Abhold; M. Baker; J. Pecos

    1999-05-01

    This manual describes the Underwater Coincidence Counter (UWCC) that has been designed for the measurement of plutonium in mixed-oxide (MOX) fuel assemblies prior to irradiation. The UWCC uses high-efficiency {sup 3}He neutron detectors to measure the spontaneous-fission and induced-fission rates in the fuel assembly. Measurements can be made on MOX fuel assemblies in air or underwater. The neutron counting rate is analyzed for singles, doubles, and triples time correlations to determine the {sup 240}Pu effective mass per unit length of the fuel assembly. The system can verify the plutonium loading per unit length to a precision of less than 1% in a measurement time of 2 to 3 minutes. System design, components, performance tests, and operational characteristics are described in this manual.

  3. Time-and-frequency-gated photon coincidence counting; a novel multidimensional spectroscopy tool

    Science.gov (United States)

    Dorfman, Konstantin E.; Mukamel, Shaul

    2016-08-01

    Coherent multidimensional optical spectroscopy is broadly applied across the electromagnetic spectrum ranging from NMR to UV. These techniques reveal the properties of matter through the correlation plots of signal fields generated in response to sequences of short pulses with variable delays. Here we discuss a new class of multidimensional techniques obtained by the time-and-frequency-resolved photon coincidence counting measurements of N photons, which constitute a 2N dimensional spectrum. A compact description of these signals is developed based on time-ordered superoperators rather than the normally ordered ordinary operators used in Glauber's photon counting formalism. The independent control of the time and frequency gate parameters reveals fine details of matter dynamics not available otherwise. These signal are illustrated for application to an anharmonic oscillator model with fluctuating energy and anharmonicity.

  4. Time-and-frequency gated photon coincidence counting; a novel multidimensional spectroscopy tool

    CERN Document Server

    Dorfman, Konstantin E

    2016-01-01

    Coherent multidimensional optical spectroscopy techniques are broadly applied across the electromagnetic spectrum ranging from NMR to the UV. These reveal properties of matter through correlation plots of signal fields generated in response to sequences of short pulses with variable delays. Here we discuss a new class of multidimensional techniques obtained by time-and-frequency resolved photon coincidence counting measurements of N photons which constitutes a 2N dimensional spectrum. A compact description of these signals is developed based on time ordered superoperators rather than the normally ordered ordinary operators used in Glauber's photon counting formalism. The independent control of the time and frequency gate parameters reveals details of matter dynamics not available otherwise. Application to an anharmonic oscillator model with fluctuating energy and anharmonicity demonstrates the power of these signals.

  5. Frequent floods in the European Alps coincide with cooler periods of the past 2500 years.

    Science.gov (United States)

    Glur, Lukas; Wirth, Stefanie B; Büntgen, Ulf; Gilli, Adrian; Haug, Gerald H; Schär, Christoph; Beer, Jürg; Anselmetti, Flavio S

    2013-09-26

    Severe floods triggered by intense precipitation are among the most destructive natural hazards in Alpine environments, frequently causing large financial and societal damage. Potential enhanced flood occurrence due to global climate change would thus increase threat to settlements, infrastructure, and human lives in the affected regions. Yet, projections of intense precipitation exhibit major uncertainties and robust reconstructions of Alpine floods are limited to the instrumental and historical period. Here we present a 2500-year long flood reconstruction for the European Alps, based on dated sedimentary flood deposits from ten lakes in Switzerland. We show that periods with high flood frequency coincide with cool summer temperatures. This wet-cold synchronism suggests enhanced flood occurrence to be triggered by latitudinal shifts of Atlantic and Mediterranean storm tracks. This paleoclimatic perspective reveals natural analogues for varying climate conditions, and thus can contribute to a better understanding and improved projections of weather extremes under climate change.

  6. Molecular photoionisation using synchrotron radiation. Photoelectron photoion coincidence and circular dichroism

    CERN Document Server

    Garcia-Macias, G A

    2002-01-01

    The first ionisation potential of the CF sub 3 radical has been determined in this work from the appearance potential of the CF sub 3 sup + fragment, formed in the photofragmentation of CF sub 3 Br. In obtaining this value special care has been taken in removing the contributions from second order light and internal energy of the fragmenting parent ion. The resulting ionisation potential was found to be in very good agreement with a number of recent theoretical calculations. The valence photoelectron spectra of three monoterpenes such as limonene, carvone and camphor have been recorded along with their mass spectra taken in coincidence with energy selected photoelectrons, providing information about state selected parent ion fragmentation channels. A new photoelectron spectrometer based on the Alien box design has been studied by ray-tracing simulations. It will include a two dimensional position sensitive detector system consisting in two micro channel plates in a chevron stack and a delay-line anode to enco...

  7. Coincident Auger electron and recoil ion momentum spectroscopy for low-energy ion-atom collisions

    Energy Technology Data Exchange (ETDEWEB)

    Laurent, G. E-mail: glaurent@ganil.fr; Tarisien, M.; Flechard, X.; Jardin, P.; Guillaume, L.; Sobocinski, P.; Adoui, L.; Bordenave-Montesquieu, A.; Bordenave-Montesquieu, D.; Chesnel, J.-Y.; Fremont, F.; Hennecart, D.; Lienard, E.; Maunoury, L.; Moretto-Capelle, P.; Cassimi, A

    2003-05-01

    The recoil ion momentum spectroscopy (RIMS) method combined with the detection of Auger electrons has been used successfully to analyse double electron capture following O{sup 6+} + He collisions at low impact velocities. Although RIMS and Auger spectroscopies are known to be efficient tools to obtain details on the primary processes occurring during the collision, the conjunction of both techniques provides new insights on the electron capture process. In the present experiment, triple coincidence detection of the scattered projectile, the target recoil ion and the Auger electron allows for a precise identification of the doubly excited states O{sup 4+} (1s{sup 2}nln{sup '}l{sup '}) populated after double electron-capture events.

  8. Intrinsically disordered tau protein in Alzheimer's tangles: a coincidence or a rule?

    Science.gov (United States)

    Skrabana, R; Skrabanova, M; Csokova, N; Sevcik, J; Novak, M

    2006-01-01

    Tau protein, the major constituent of neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies, is classified as intrinsically disordered protein (IDP). IDPs in contrast to globular proteins contain high proportion of polar and charged amino acids in their sequence, which results in the absence of a well-defined three-dimensional structure of the free protein. Structural flexibility of IDPs is required to perform their important role in many cellular processes. In the course of tauopathies, highly soluble disordered tau protein acquires rigid fold and forms highly insoluble filaments. Beneficial intrinsic disorder transforms into a fatal order: is it a coincidence, or is there an underlying reason for preferential IDPs assembly? In this review we present the structural characteristics of tau protein filamentous lesions in AD and discuss the tendency of IDPs to assembly and to form amyloid deposits (Ref: 65).

  9. True coincidence summing corrections for an extended energy range HPGe detector

    Energy Technology Data Exchange (ETDEWEB)

    Venegas-Argumedo, Y. [Centro de Investigación en Materiales Avanzados (CIMAV), Miguel de Cervantes 120, Chihuahua, Chih 31109 (Mexico); M.S. Student at CIMAV (Mexico); Montero-Cabrera, M. E., E-mail: elena.montero@cimav.edu.mx [Centro de Investigación en Materiales Avanzados (CIMAV), Miguel de Cervantes 120, Chihuahua, Chih 31109 (Mexico)

    2015-07-23

    True coincidence summing (TCS) effect for natural radioactive families of U-238 and Th-232 represents a problem when an environmental sample with a close source-detector geometry measurement is performed. By using a certified multi-nuclide standard source to calibrate an energy extended range (XtRa) HPGe detector, it is possible to obtain an intensity spectrum slightly affected by the TCS effect with energies from 46 to 1836 keV. In this work, the equations and some other considerations required to calculate the TCS correction factor for isotopes of natural radioactive chains are described. It is projected a validation of the calibration, performed with the IAEA-CU-2006-03 samples (soil and water)

  10. Comparative research of Symbiodinium diversity associated with two color morphs of reef-building coral Galaxea fascicularis%丛生盔形珊瑚的2种颜色群体共生藻组成比较

    Institute of Scientific and Technical Information of China (English)

    周国伟; 黄晖; 喻子牛; 尤丰; 李秀保

    2011-01-01

    造礁石珊瑚与共生藻 Symbiodinium spp.的互利共生对维护多样性极为丰富的珊瑚礁生态系统至关重要.在受到诸如水温异常等环境胁迫时,宿主珊瑚会排出体内共生藻而导致珊瑚白化直至死亡.造礁石珊瑚群体丰富的颜色对于珊瑚适应环境有着重要的作用,即使是同种造礁石珊瑚的不同群体,它们在颜色上也会有差异.丛生盔形珊瑚 Galaxea.fascicularis 作为印度-太平洋区系常见种广泛分布于海南三亚珊瑚礁海域,不同群体的颜色相异.对绿色和褐色2种颜色的丛生盔形珊瑚群体共生藻的28S rDNA进行限制性片段长度多态性(polymerase chainreaction-restrictionfragmentlength polymorphism,PCR-RFLP)分析,结果显示,该珊瑚可以与C和D系群共生藻分别或同时共生.此外,丛生盔形珊瑚2种颜色群体的共生藻组成并无显著差异,表明珊瑚群体的颜色差异与共生藻的组成并无直接联系.影响珊瑚表型颜色的因素复杂,包括珊瑚的绿色荧光蛋白(green fluorescent protein,GFP)、珊瑚和共生藻的各种色素等,具体机理需要进一步研究.%The symbiotic association between corals and Symbiodinium is a major contributing factor in the success of coral reef ecosystem with high biodiversity.Under stressful environmental conditions, such as abnormally high water temperatures, this symbiosis can break down and the zooxanthellae are lost in a process known as "bleaching", which can cause the death of corals if stresses are severe or persistent.Reef-building corals have diverse colors even in different colonies within the same species, and the color plays a key role in acclimation of coral to environment.Galaxea fascicularis is a common reef-building coral in the Indo-Pacific area, including the coral reef areas in Sanya, Hainan Island, and displays a variety colors even with different colonies.The authors used PCR-RFLP to investigate whether or not variation in color is associated

  11. Alpha particle spectra in coincidence with normal and superdeformed states in {sup 150}Tb

    Energy Technology Data Exchange (ETDEWEB)

    Viesti, G.; Lunardon, M.; Bazzacco, D. [dell`Universita, Padova (Italy)]|[INFN, Padova (Italy)] [and others

    1996-12-31

    The study of correlations between particle evaporation from highly excited compound nuclei at large angular momenta and the states in the final evaporation residues (ER) is a field of investigation which has been opened, in the last years, with the advent of the new large {gamma}-ray arrays. It is now possible to correlate the evaporation spectra to various bands with shapes ranging from spherical to superdeformed (SD) in the same final nucleus. It is generally accepted that the particle evaporation from the compound nucleus is chaotic and that only in the near-yrast {gamma} cascade, where the feeding of different classes of states takes place, the ordered motion is restored. The sensitivity of the particle spectra on the feeding of specific states in the residual nuclei can be taken as an indication that additional degrees of freedom might be important in the evaporation process or that particular regions of the phase space open to the decay populate preferentially some selected structures in the final cold nucleus. This latter point is important for the understanding of the feeding mechanism of SD states. Several experiments performed so far did not find a clear dependence of the shapes of the particle spectra on the excited states having different deformations in the ER. For example, the proton spectra in coincidence with transitions in the SD bands of {sup 133}Nd and {sup 152}Dy nuclei were found to be similar to those in coincidence with transitions in the normal deformed (ND) bands. Alpha particles have been proposed since long as a sensitive probe of the deformation of the emitting nucleus. Results are presented here of an experiment in which the authors have measured the energy spectra of alpha particles associated with different classes of states (ND and SD) in the {sup 150}Tb nucleus populated in the reaction {sup 37}Cl({sup 120}Sn, {alpha}3n{gamma}){sup 150}Tb.

  12. Evaluation Of The Coincidence Of Male Pattern Baldness And Pityrosporum Group Of Fungus In Iran

    Directory of Open Access Journals (Sweden)

    Javanbakht Arash

    2002-01-01

    Full Text Available The aetilogy of male pattern baldness (MPB is not clearly found yet. The present study has been designed to determine if three is a significant statistical coincidence between MPB and pityrosporm group of fungal infection. This cross-sectional study covers 50 men with the diagnosis of MPB who visited the dermatology clinic of Qaem hospital of Mashhad Medical University as the case group and 43 men with no evidence of MPB as the control group. A questionnaire was filled out for each person of the two groups and mycological sampling was done from three parts of the case group scalp (bald, balding, intact areas and two parts of the control group scalp (vertex and parietal. All the data were analysed using the software SPSS 10.00 and Chi-square, Pearson Chi-square and Friedman tests. Results showed that there was no difference between different degrees of infection in the intact area (p>0.05. Among the three parts of the case group scalp, bald area had the highest degree of infection (p<0.001. The degree of infection in the bald area of the case group scalp was higher than that of the vertex area of the control group scalp (p<0.001, while there was no difference between the degrees of infection in the intact area of the case group scalp and the parietal area of the control group scalp (p>0.05. This study supports some previous studies that claimed that there might be coincidence between MPB and pityrosporum fungal infection.

  13. Detector system for the study of low energy heavy ion reactions using kinematic coincidence technique

    Energy Technology Data Exchange (ETDEWEB)

    Jhingan, Akhil, E-mail: akhil@iuac.res.in [Inter University Accelerator Centre, P. O. Box 10502, New Delhi 110067 (India); Kalkal, S. [Deptartment of Physics and Astrophysics, Delhi University, Delhi 110007 (India); Sugathan, P.; Golda, K.S.; Ahuja, R.; Gehlot, J.; Madhavan, N. [Inter University Accelerator Centre, P. O. Box 10502, New Delhi 110067 (India); Behera, B.R. [Deptartment of Physics, Panjab University, Chandigarh 160014 (India); Mandal, S.K. [Deptartment of Physics and Astrophysics, Delhi University, Delhi 110007 (India)

    2014-05-01

    The characteristics and performance of a new detector system developed for the study of low energy heavy ion binary reactions using the kinematic coincidence technique are presented. The detector system has been developed to carry out experiments such as multi-nucleon transfer reactions using the General Purpose Scattering Chamber (GPSC) facility at IUAC [1,2]. The detector system consists of a pair of two-dimensional position sensitive multi wire proportional counter (MWPC) and a ΔE−E gas ionization chamber. Both MWPC have an active area of 5×5 cm{sup 2}, and provide position signals in horizontal (X) and vertical (Y) plane, and timing signal for time of flight measurements. The main design feature of MWPC is the reduced wire pitch of 0.025 in. (0.635 mm) in all electrodes, giving uniform field and faster charge collection, and usage of 10μm diameter in anode frame which gives higher gains. The position resolution of the detectors was determined to be 0.45 mm FWHM and time resolution was estimated to be 400 ps FWHM. The detector could handle heavy ion count rates exceeding 100 kHz without any break down. The timing and position signals of the detectors are used for kinematic coincidence measurements and subsequent extraction of their mass and angular distributions. The ionization chamber has a conventional transverse field geometry with segmented anode providing multiple ΔE signals for nuclear charge (Z) identification. This article describes systematic study of these detectors in terms of efficiency, count rate handling capability, time, position and energy resolution.

  14. Assessing Photosynthesis by Fluorescence Imaging

    Science.gov (United States)

    Saura, Pedro; Quiles, Maria Jose

    2011-01-01

    This practical paper describes a novel fluorescence imaging experiment to study the three processes of photochemistry, fluorescence and thermal energy dissipation, which compete during the dissipation of excitation energy in photosynthesis. The technique represents a non-invasive tool for revealing and understanding the spatial heterogeneity in…

  15. X-ray Fluorescence Sectioning

    CERN Document Server

    Cong, Wenxiang

    2012-01-01

    In this paper, we propose an x-ray fluorescence imaging system for elemental analysis. The key idea is what we call "x-ray fluorescence sectioning". Specifically, a slit collimator in front of an x-ray tube is used to shape x-rays into a fan-beam to illuminate a planar section of an object. Then, relevant elements such as gold nanoparticles on the fan-beam plane are excited to generate x-ray fluorescence signals. One or more 2D spectral detectors are placed to face the fan-beam plane and directly measure x-ray fluorescence data. Detector elements are so collimated that each element only sees a unique area element on the fan-beam plane and records the x-ray fluorescence signal accordingly. The measured 2D x-ray fluorescence data can be refined in reference to the attenuation characteristics of the object and the divergence of the beam for accurate elemental mapping. This x-ray fluorescence sectioning system promises fast fluorescence tomographic imaging without a complex inverse procedure. The design can be ad...

  16. Optical Properties of Fluorescent Dyes

    Institute of Scientific and Technical Information of China (English)

    李戎; 陈东辉

    2001-01-01

    Fluorescent dyes have been widely used these years.Because of the special optical performance, conventional CCM systems seem to be unable to predict the recipes of fabrics dyed with fluorescent dyes. In order to enhance the functions of CCM systems, the optical properties of fluorescent dyes in their absorption region were investigated. It has been found that there was a fixed maximum absorption wavelength for each fluorescent dyes whatever its concentration is. Both absorption region and maximum absorption wavelength of the dyes in solution are the same to those in fabric, and that the absorption is directly proportional to the concentration of the dye. So the optical properties obtained in solutions cna be applied for describing the optics performance of fluorescent dyes in fabrics.

  17. Fluorescence calibration method for single-particle aerosol fluorescence instruments

    Science.gov (United States)

    Shipley Robinson, Ellis; Gao, Ru-Shan; Schwarz, Joshua P.; Fahey, David W.; Perring, Anne E.

    2017-05-01

    Real-time, single-particle fluorescence instruments used to detect atmospheric bioaerosol particles are increasingly common, yet no standard fluorescence calibration method exists for this technique. This gap limits the utility of these instruments as quantitative tools and complicates comparisons between different measurement campaigns. To address this need, we have developed a method to produce size-selected particles with a known mass of fluorophore, which we use to calibrate the fluorescence detection of a Wideband Integrated Bioaerosol Sensor (WIBS-4A). We use mixed tryptophan-ammonium sulfate particles to calibrate one detector (FL1; excitation = 280 nm, emission = 310-400 nm) and pure quinine particles to calibrate the other (FL2; excitation = 280 nm, emission = 420-650 nm). The relationship between fluorescence and mass for the mixed tryptophan-ammonium sulfate particles is linear, while that for the pure quinine particles is nonlinear, likely indicating that not all of the quinine mass contributes to the observed fluorescence. Nonetheless, both materials produce a repeatable response between observed fluorescence and particle mass. This procedure allows users to set the detector gains to achieve a known absolute response, calculate the limits of detection for a given instrument, improve the repeatability of the instrumental setup, and facilitate intercomparisons between different instruments. We recommend calibration of single-particle fluorescence instruments using these methods.

  18. In situ measurement of airway surface liquid [K+] using a ratioable K+-sensitive fluorescent dye.

    Science.gov (United States)

    Namkung, Wan; Song, Yuanlin; Mills, Aaron D; Padmawar, Prashant; Finkbeiner, Walter E; Verkman, A S

    2009-06-05

    The airway surface liquid (ASL) is the thin fluid layer lining airway surface epithelial cells, whose volume and composition are tightly regulated and may be abnormal in cystic fibrosis (CF). We synthesized a two-color fluorescent dextran to measure ASL [K(+)], TAC-Lime-dextran-TMR, consisting of a green-fluorescing triazacryptand K(+) ionophore-Bodipy conjugate, coupled to dextran, together with a red fluorescing tetramethylrhodamine reference chromophore. TAC-Lime-dextran-TMR fluorescence was K(+)-selective, increasing >4-fold with increasing [K(+)] from 0 to 40 mm. In well differentiated human airway epithelial cells, ASL [K(+)] was 20.8 +/- 0.3 mm and decreased by inhibition of the Na(+)/K(+) pump (ouabain), ENaC (amiloride), CF transmembrane conductance regulator (CFTR(inh)-172), or K(+) channels (TEA or XE991). ASL [K(+)] was increased by forskolin but not affected by Na(+)/K(+)/2Cl(-) cotransporter inhibition (bumetanide). Functional and expression studies indicated the involvement of [K(+)] channels KCNQ1, KCNQ3, and KCNQ5 as determinants of ASL [K(+)]. [K(+)] in CF cultures was similar to that in non-CF cultures, suggesting that abnormal ASL [K(+)] is not a factor in CF lung disease. In intact airways, ASL [K(+)] was also well above extracellular [K(+)]: 22 +/- 1 mm in pig trachea ex vivo and 16 +/- 1 mm in mouse trachea in vivo. Our results provide the first noninvasive measurements of [K(+)] in the ASL and indicate the involvement of apical and basolateral membrane ion transporters in maintaining a high ASL [K(+)].

  19. Single Molecule Spectroscopy of Fluorescent Proteins

    NARCIS (Netherlands)

    Blum, Christian; Subramaniam, Vinod

    2009-01-01

    The discovery and use of fluorescent proteins has revolutionized cellular biology. Despite the widespread use of visible fluorescent proteins as reporters and sensors in cellular environments the versatile photophysics of fluorescent proteins is still subject to intense research. Understanding the

  20. FLEX: fluorescence explorer

    Science.gov (United States)

    Stoll, Marc-Ph.; Court, Andrew; Smorenburg, Kees; Visser, Huib; Crocco, Luiggi; Heilimo, Jyro; Honig, Andre

    1999-12-01

    FLEX is a scientifically driven space mission to provide demonstration/validation of the instrumentation and technique for measuring the natural fluorescence of vegetation in the Fraunhofer lines. The payload consists of high spectral resolution (0.1 - 0.3 nm) CCD imaging grating spectrometer with two channels: one in the red (648 - 664 nm) and one in the blue (391 - 438 nm) for working with several Fraunhofer lines. The across track FOV is 8.4 degrees; ground spatial resolution is better than 0.5 X 0.5 km2. To increase the S/N ratio a steering mirror will be used, if necessary, to 'freeze' the image and also to provide plus or minus 4 degrees across track depointing. Calibration is made by viewing the sun via a diffuser plate switched into the telescope field of view. A separate CCD camera will allow cloud detection and scene identification. A TIR radiometer will provide simultaneous surface temperature measurements. The spacecraft, overall mass estimated at 200 kg, is derived from the ASI-MITA bus which provides all the necessary subsystems and stabilized platform. By use of on-board storage, ground requirements for satellite control and data link are minimized; the possibility of local stations for real time reception/distribution is also envisaged. Provisional orbit characteristics are: LEO sun synchronous, 500 - 900 km altitude. Priority will be given to highest revisit frequency on a sufficient number of selected test sites.