WorldWideScience

Sample records for two-bladed teetering hub

  1. Development of passive-controlled HUB (teetered brake & damper mechanism) of horizontal axis wind turbine

    Energy Technology Data Exchange (ETDEWEB)

    Shimizu, Yukimaru; Kamada, Yasunari; Maeda, Takao [Mie Univ. (Japan)

    1997-12-31

    For the purpose of the improvement of reliability of the Mega-Watt wind turbine, this paper indicates the development of an original mechanism for the passive-controlled hub, which has the effects of braking and damping on aerodynamic forces. This mechanism is useful for variable speed control of the large wind turbine. The passive-controlled hub is the combination of two mechanisms. One is the passive-teetered and damping mechanism, and the other is the passive-variable-pitch mechanism. These mechanism are carried out by the combination of the teetering and feathering motions. When the wind speed exceeds the rated wind speed, the blade is passively teetered in a downwind direction and, simultaneously, a feathering mechanism, which is linked to the teetering mechanism through a connecting rods, is activated. Testing of the model horizontal axis wind turbine in a wind tunnel showed that the passive-controlled hub mechanism can suppress the over-rotational speed of the rotor. By the application of the passive-controlled hub mechanism, the maximum rotor speed is reduced to about 60%.

  2. A Two-Bladed Teetering Hub configuration for the DTU 10 MW RWT: loads considerations

    DEFF Research Database (Denmark)

    Bergami, Leonardo; Aagaard Madsen, Helge; Rasmussen, Flemming

    2014-01-01

    , and the rotor solidity is kept constant by increasing the blade chord by 50 %. The configuration allows saving 30 % of the rotor weight and material, corresponding to one blade, but implies several complications: lower power output due to increased tip losses effects, and increased load variations. The increase...

  3. A Two-Bladed Teetering Hub configuration for the DTU 10 MW RWT: loads considerations

    DEFF Research Database (Denmark)

    Bergami, Leonardo; Aagaard Madsen, Helge; Rasmussen, Flemming

    , and the rotor solidity is kept constant by increasing the blade chord by 50 %. The configuration allows saving 30 % of the rotor weight and material, corresponding to one blade, but implies several complications: lower power output due to increased tip losses effects, and increased load variations. The increase...

  4. User`s Guide for the NREL Teetering Rotor Analysis Program (STRAP)

    Energy Technology Data Exchange (ETDEWEB)

    Wright, A D

    1992-08-01

    The following report gives the reader an overview of instructions on the proper use of the National Renewable Energy Laboratory (formerly the Solar Energy Research Institute, or SERI) teetering Rotor Analysis Program (STRAP version 2.20). STRAP is a derivative of the Force and Loads Analysis program (FLAP). It is intended as a tool for prediction of rotor and blade loads and response for only two-bladed teetering hub wind turbines. The effects of delta-3, undersling, hub mass, and wind turbulence are accounted for. The objectives of the report are to give an overview of the code and also show the methods of data input and correct code execution steps in order to model an example two-bladed teetering hub turbine. A large portion of the discussion (Sections 6.0, 7.0, and 8.0) is devoted to the subject of inputting and running the code for wind turbulence effects. The ability to include turbulent wind effects is perhaps the biggest change in the code since the release of FLAP version 2.01 in 1988. This report is intended to be a user`s guide. It does not contain a theoretical discussion on equations of motion, assumptions, underlying theory, etc. It is intended to be used in conjunction with Wright, Buhl, and Thresher (1988).

  5. User's Guide for the NREL Teetering Rotor Analysis Program (STRAP). [National Renewable Energy Laboratory (NREL)

    Energy Technology Data Exchange (ETDEWEB)

    Wright, A.D.

    1992-08-01

    The following report gives the reader an overview of instructions on the proper use of the National Renewable Energy Laboratory (formerly the Solar Energy Research Institute, or SERI) teetering Rotor Analysis Program (STRAP version 2.20). STRAP is a derivative of the Force and Loads Analysis program (FLAP). It is intended as a tool for prediction of rotor and blade loads and response for only two-bladed teetering hub wind turbines. The effects of delta-3, undersling, hub mass, and wind turbulence are accounted for. The objectives of the report are to give an overview of the code and also show the methods of data input and correct code execution steps in order to model an example two-bladed teetering hub turbine. A large portion of the discussion (Sections 6.0, 7.0, and 8.0) is devoted to the subject of inputting and running the code for wind turbulence effects. The ability to include turbulent wind effects is perhaps the biggest change in the code since the release of FLAP version 2.01 in 1988. This report is intended to be a user's guide. It does not contain a theoretical discussion on equations of motion, assumptions, underlying theory, etc. It is intended to be used in conjunction with Wright, Buhl, and Thresher (1988).

  6. A Two-Bladed Concept Wind Turbine

    DEFF Research Database (Denmark)

    Kim, Taeseong

    2012-01-01

    This article shows the potential for reducing extreme loads with an innovative design of wind turbine, a partial pitch two-bladed concept turbine. The most extreme conditions to test a turbine are considered to be stand-still combined with a grid failure in which the wind comes from all directions...... from 0 to 360 degrees. All aeroelastic load simulations are done by using the aeroelastic code HAWC2. From the load comparisons between the partial pitch two-bladed turbine and a conventional three-bladed turbine it is observed that the partial pitch two-bladed turbine can reduce the extreme tower...... bottom bending moment by approximately 33% compared to the three-bladed turbine....

  7. A Two-Bladed Concept Wind Turbine

    DEFF Research Database (Denmark)

    Kim, Taeseong

    2012-01-01

    This article shows the potential for reducing extreme loads with an innovative design of wind turbine, a partial pitch two-bladed concept turbine. The most extreme conditions to test a turbine are considered to be stand-still combined with a grid failure in which the wind comes from all directions...... from 0 to 360 degrees. All aeroelastic load simulations are done by using the aeroelastic code HAWC2. From the load comparisons between the partial pitch two-bladed turbine and a conventional three-bladed turbine it is observed that the partial pitch two-bladed turbine can reduce the extreme tower...... bottom bending moment by approximately 33% compared to the three-bladed turbine....

  8. Analysis and test results for a two-bladed, passive cycle pitch, horizontal-axis wind turbine in free and controlled yaw

    Energy Technology Data Exchange (ETDEWEB)

    Holenemser, K.H. [Washington Univ., St. Louis, MO (United States)

    1995-10-01

    This report surveys the analysis and tests performed at Washington University in St. Louis, Missouri, on a horizontal-axis, two-laded wind turbine with teeter hub. The introduction is a brief account of results obtained during the 5-year period ending December 1985. The wind tunnel model and the test turbine (7.6 m [25 ft.] in diameter) at Washington University`s Tyson Research Center had a 67{degree} delta-three angle of the teeter axis. The introduction explains why this configuration was selected and named the passive cycle pitch (PCP) wind turbine. Through the analysis was not limited to the PCP rotor, all tests, including those done from 1986 to 1994, wee conducted with the same teetered wind rotor. The blades are rather stiff and have only a small elastic coning angle and no precone.

  9. Rezension zu: Emily Teeter (Hg.), Before the pyramids. The origins of Egyptian civilization

    OpenAIRE

    Köpp-Junk, Heidi

    2013-01-01

    Rezension zu: Emily Teeter (Hg.), Before the Pyramids. The Origins of Egyptian Civilization. The Oriental Institute of the University of Chicago, Oriental Institute Museum Publications 33 (Chicago 2011)

  10. Analysis of a teetered, variable-speed rotor: final report

    Energy Technology Data Exchange (ETDEWEB)

    Weber, T L; Wilson, R E; Walker, S N [Oregon State Univ., Corvallis, OR (USA). Dept. of Mechanical Engineering

    1991-06-01

    A computer model of a horizontal axis wind turbine (HOOT) with four structural degrees of freedom has been derived and verified. The four degrees of freedom include flapwise motion of the blades, teeter motion, and variable rotor speed. Options for the variable rotor speed include synchronous, induction, and constant-tip speed generator models with either start, stop, or normal operations. Verification is made by comparison with analytical solutions and mean and cyclic ESI-80 data. The Veers full-field turbulence model is used as a wind input for a synchronous and induction generator test case during normal operation. As a result of the comparison, it is concluded that the computer model can be used to predict accurately mean and cyclic loads with a turbulent wind input. 47 refs., 19 figs.

  11. Innovation hubs

    DEFF Research Database (Denmark)

    O´Hara, J.; Hansen, Poul H. Kyvsgård; Turner, N.

    2008-01-01

    "Whilst ‘incremental innovation' is an imperative for the short-to-medium term success of a company, there is also a need for companies to engage in innovation activity that goes beyond the incremental in order to guarantee long-term success. However, such ‘radical innovation' (RI) poses new...... challenges and requires new competencies, some of which may conflict with existing best-practices for incremental innovations. ‘Innovation hubs' are a type of organisational structure dedicated to RI projects that have been used by companies to manage these conflicts by maintaining a certain degree...... of separation from the culture and routines of the mainstream organisation. Unfortunately, it would appear that many attempts to set-up innovation hubs have ended in failure within a few years; not before considerable time, effort and resource has been expended. This paper reports on a study of six innovation...

  12. Innovation hubs

    DEFF Research Database (Denmark)

    O´Hara, J.; Hansen, Poul H. Kyvsgård; Turner, N.

    2008-01-01

    "Whilst ‘incremental innovation' is an imperative for the short-to-medium term success of a company, there is also a need for companies to engage in innovation activity that goes beyond the incremental in order to guarantee long-term success. However, such ‘radical innovation' (RI) poses new...... challenges and requires new competencies, some of which may conflict with existing best-practices for incremental innovations. ‘Innovation hubs' are a type of organisational structure dedicated to RI projects that have been used by companies to manage these conflicts by maintaining a certain degree...... of separation from the culture and routines of the mainstream organisation. Unfortunately, it would appear that many attempts to set-up innovation hubs have ended in failure within a few years; not before considerable time, effort and resource has been expended. This paper reports on a study of six innovation...

  13. Modal dynamics of structures with bladed isotropic rotors and its complexity for two-bladed rotors

    Directory of Open Access Journals (Sweden)

    M. H. Hansen

    2016-11-01

    These harmonic terms lead to modal couplings for the two-bladed turbine that do not exist for the three-bladed turbine. A single mode of a two-bladed turbine will also have several resonance frequencies in both the ground-fixed and rotating frames of reference, which complicates the interpretation of simulated or measured turbine responses.

  14. Large-eddy simulation analysis of turbulent flow over a two-blade horizontal wind turbine rotor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Tae Young [Dept. of Mechanical Engineering, Carnegie Mellon University, Pittsburgh (United States); You, Dong Hyun [Dept. of Mechanical Engineering, Pohang University of Science and Technology, Pohang (Korea, Republic of)

    2016-11-15

    Unsteady turbulent flow characteristics over a two-blade horizontal wind turbine rotor is analyzed using a large-eddy simulation technique. The wind turbine rotor corresponds to the configuration of the U.S. National Renewable Energy Laboratory (NREL) phase VI campaign. The filtered incompressible Navier-Stokes equations in a non-inertial reference frame fixed at the centroid of the rotor, are solved with centrifugal and Coriolis forces using an unstructured-grid finite-volume method. A systematic analysis of effects of grid resolution, computational domain size, and time-step size on simulation results, is carried out. Simulation results such as the surface pressure coefficient, thrust coefficient, torque coefficient, and normal and tangential force coefficients are found to agree favorably with experimental data. The simulation showed that pressure fluctuations, which produce broadband flow-induced noise and vibration of the blades, are especially significant in the mid-chord area of the suction side at around 70 to 95 percent spanwise locations. Large-scale vortices are found to be generated at the blade tip and the location connecting the blade with an airfoil cross section and the circular hub rod. These vortices propagate downstream with helical motions and are found to persist far downstream from the rotor.

  15. Natural Gas Market Hubs

    Data.gov (United States)

    Department of Homeland Security — A hub is a physical transfer point for natural gas where several pipelines are connected. A market center is a hub where the operator offers services that facilitate...

  16. Quadratic Assignment of Hubs in p-Hub Median Problem

    DEFF Research Database (Denmark)

    Gelareh, Shahin

    We introduce Generalized p-Hub Median Problem (GpHMP) that seeks to locate p hub nodes and install p distinct hub facilities/operators on the hubs while discount factor resulted by consolidation of flow on the hub links depends on the facilities/operators that are installed/operating on both hub...... nodes end-point. In contrast, in traditional hub location problems it is commonly assumed that all the hub facilities share a similar characteristic and economy of scale resulted by consolidation of flow over hub edges is not directly relevant to the hub facilities being installed at both end...

  17. Virtual Campus Hub technology

    DEFF Research Database (Denmark)

    Vercoulen, Frank; Badger, Merete; Monaco, Lucio;

    This deliverable briefly describes which technological components have been delivered for the Virtual Campus Hub and how they can be used. A detailed discussion of the technical details of the components, how they were realized and how they fit the VCH concept can be found in deliverables D5.......4. Virtual Campus Hub Technology Evaluation Report and D6.7 The Virtual Campus Hub Concept....

  18. Aircraft Propeller Hub Repair

    Energy Technology Data Exchange (ETDEWEB)

    Muth, Thomas R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Peter, William H. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-02-13

    The team performed a literature review, conducted residual stress measurements, performed failure analysis, and demonstrated a solid state additive manufacturing repair technique on samples removed from a scrapped propeller hub. The team evaluated multiple options for hub repair that included existing metal buildup technologies that the Federal Aviation Administration (FAA) has already embraced, such as cold spray, high velocity oxy-fuel deposition (HVOF), and plasma spray. In addition the team helped Piedmont Propulsion Systems, LLC (PPS) evaluate three potential solutions that could be deployed at different stages in the life cycle of aluminum alloy hubs, in addition to the conventional spray coating method for repair. For new hubs, a machining practice to prevent fretting with the steel drive shaft was recommended. For hubs that were refurbished with some material remaining above the minimal material condition (MMC), a silver interface applied by an electromagnetic pulse additive manufacturing method was recommended. For hubs that were at or below the MMC, a solid state additive manufacturing technique using ultrasonic welding (UW) of thin layers of 7075 aluminum to the hub interface was recommended. A cladding demonstration using the UW technique achieved mechanical bonding of the layers showing promise as a viable repair method.

  19. The effect of {delta}{sub 3} angle on the teeter response of an unstalled wind turbine rotor determined by analysis, experiment, and computer simulation

    Energy Technology Data Exchange (ETDEWEB)

    Swift, A.H.P.; Moroz, E.M.; Craver, W.L. [Univ. of Texas, El Paso, TX (United States). Dept. of Mechanical and Industrial Engineering

    1995-09-01

    A large, positive {delta}{sub 3} angle offers some advantages over the usual zero {delta}{sub 3} teeter rotor;such as reduced flapping angles, reduced inplane excitations, and reduced teeter restraint impact loading. This paper discusses these advantages and presents results from theoretical analyses, computer simulations, and atmospheric test on the University of Texas at El Paso (UTEP) test-bed turbine. Results from these simulations and tests indicate stable and controlled teeter response at high yaw angles and yaw rates at wind speeds up to 30 m/s. Results of atmospheric tests also show reasonable correlation with the code TEETER, but some discrepancies with past and present versions of the code YAWDYN.

  20. The effect of {delta}{sub 3} angle on the teeter response of an unstalled wind turbine rotor determined by analysis, experiment, and computer simulation

    Energy Technology Data Exchange (ETDEWEB)

    Swift, A.P.; Moroz, E.M.; Craver, W.L. [Texas Univ., El Paso, TX (United States)

    1995-12-31

    A large, positive {delta}{sub 3} offers some advantages over the usual zero {delta}{sub 3} teeter rotor; such as reduced flapping angles, reduced inplane excitations, and reduced teeter restraint impact loading. This paper discusses these advantages and presents results from theoretical analyses, computer simulations, and atmospheric tests on the University of Texas at El Paso (UTEP) test-bed turbine. Results from these simulations and test indicate stable and controlled teeter response at high yaw angles and yaw rates at wind speeds up to 30 m/s. Results of atmospheric tests also show reasonable correlation with the code TEETER, but some discrepancies with past and present versions of the code YAWDYN. (Author)

  1. Twin Hub Network (poster)

    NARCIS (Netherlands)

    Kreutzberger, E.D.; Konings, J.W.

    2014-01-01

    Twin hub network, a European Interreg IVB project, aims at making intermodal rail transport within, to and from North West Europe more competitive, in particular between seaports and inland terminals. Improving rail competitiveness enables to shift freight flows from road to rail, providing a more s

  2. Iterative tuning of feedforward IPC for two-bladed wind turbines

    Science.gov (United States)

    Mulders, SP; van Solingen, E.; van Wingerden, JW; Beerens, J.

    2016-09-01

    At present, the cost of offshore wind energy does not meet the level of onshore wind and fossil-based energy sources. One way to extend the turbine lifetime, and thus reduce cost, is by reduction of the fatigue loads of blades and other turbine parts using Individual Pitch Control (IPC). This type of control, which is generally implemented by feedback control using the MultiBlade Coordinate transformation on blade load measurement signals, is capable of mitigating the most dominant periodic loads. The main goal of this article is to develop a self-optimizing feedforward IPC strategy for a two-bladed wind turbine to reduce actuator duty cycle and reduce the dependency on blade load measurement signals. The approach uses blade load measurement data only initially for tuning of the feedforward controller, which is scheduled on the rotor azimuth angle and wind speed. The feedforward strategy will be compared to the feedback implementation in terms of load alleviation capabilities and actuator duty cycle. Results show that the implementation is capable of learning the optimal feedforward IPC controller in constant and turbulent wind conditions, to alleviate the pitch actuator duty cycle, and to considerably reduce harmonic fatigue loads without the need for blade load measurement signals after tuning.

  3. Transport hub flow modelling

    OpenAIRE

    Despagne, Wilfried; Frenod, Emmanuel

    2014-01-01

    Purpose: The purpose of this paper is to investigate the road freight haulage activity. Using the physical and data flow information from a freight forwarder, we intend to model the flow of inbound and outbound goods in a freight transport hub. Approach: This paper presents the operation of a road haulage group. To deliver goods within two days to any location in France, a haulage contractor needs to be part of a network. This network handles the processing of both physical goods and data. We...

  4. GitHub Android

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    代码托管仓库GitHub发布了官方,Android客户端,手机和平板用户可以从GoogleP1ay下载。它的出现,将方便更多用户融入GitHub社区。GitHubAndroid本身也是开源软件,其源代码可以从GitHub浏览。此前,GitHub已经推出了Windows和Mac版客户端。

  5. PORTS WRESTLE FOR HUB STATUS

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Due to the fact that there has been nocontainer transport hub port in NorthernChina,northern ports are striving fordevelopment and trying to secure a positionof being the hub port in Northern Chinaahead of others. According to media reports,EasternChina’s Shandong Province will invest 5billion yuan(US$604 million)in buildinga Qingdao international shipping hub thatisbased on existing ports in theShandong Peninsula.

  6. Water Flow Testing and Unsteady Pressure Analysis of a Two-Bladed Liquid Oxidizer Pump Inducer

    Science.gov (United States)

    Schwarz, Jordan B.; Mulder, Andrew; Zoladz, Thomas

    2011-01-01

    The unsteady fluid dynamic performance of a cavitating two-bladed oxidizer turbopump inducer was characterized through sub-scale water flow testing. While testing a novel inlet duct design that included a cavitation suppression groove, unusual high-frequency pressure oscillations were observed. With potential implications for inducer blade loads, these high-frequency components were analyzed extensively in order to understand their origins and impacts to blade loading. Water flow testing provides a technique to determine pump performance without the costs and hazards associated with handling cryogenic propellants. Water has a similar density and Reynolds number to liquid oxygen. In a 70%-scale water flow test, the inducer-only pump performance was evaluated. Over a range of flow rates, the pump inlet pressure was gradually reduced, causing the flow to cavitate near the pump inducer. A nominal, smooth inducer inlet was tested, followed by an inlet duct with a circumferential groove designed to suppress cavitation. A subsequent 52%-scale water flow test in another facility evaluated the combined inducer-impeller pump performance. With the nominal inlet design, the inducer showed traditional cavitation and surge characteristics. Significant bearing loads were created by large side loads on the inducer during synchronous cavitation. The grooved inlet successfully mitigated these loads by greatly reducing synchronous cavitation, however high-frequency pressure oscillations were observed over a range of frequencies. Analytical signal processing techniques showed these oscillations to be created by a rotating, multi-celled train of pressure pulses, and subsequent CFD analysis suggested that such pulses could be created by the interaction of rotating inducer blades with fluid trapped in a cavitation suppression groove. Despite their relatively low amplitude, these high-frequency pressure oscillations posed a design concern due to their sensitivity to flow conditions and

  7. Indico: A Collaboration Hub

    CERN Document Server

    Ferreira, P; Bossy, C; Gonzalez, J B; Pugh, M; Resco, A; Trzaskoma, J; Wachter, C

    2012-01-01

    Since 2009, the development of Indico has focused on usability, performance and new features, especially the ones related to meeting collaboration. Usability studies have resulted in the biggest change Indico has experienced up to now, a new web layout that makes user experience better. Performance improvements were also a key goal since 2010; the main features of Indico have been optimized remarkably. Along with usability and performance, new features have been added to Indico such as webchat integration, video services bookings, webcast and recording requests, designed to really reinforce Indico position as the main hub for all CERN collaboration services, and many others which aim is to complete the conference lifecycle management. Indico development is also moving towards a broader collaboration where other institutes, hosting their own Indico instance, can contribute to the project in order make it a better and more complete tool.

  8. The Virtual Campus Hub Concept

    DEFF Research Database (Denmark)

    Badger, Merete; Prag, Sidsel-Marie Winther; Monaco, Lucio

    of Technology in Sweden, Politecnico di Torino in Italy, and Eindhoven University of Technology in the Netherlands. The project is partially funded by the European Commission under the 7th Framework Programme (project no. RI-283746). This report describes the final concept of Virtual Campus Hub. It gives...... an overview of the project achievements and recommends best practices for the use of the Virtual Campus Hub elements: a series of applications for online teaching and collaboration which are connected to a technical platform, the Virtual Campus Hub portal, using the European research infrastructure Géant/eduGAIN....

  9. A new transport hub

    CERN Multimedia

    Corinne Pralavorio

    2016-01-01

    CERN’s new Mobility Centre, allowing you to switch easily from one mode of transport to another, has just been officially opened.   Inauguration of the CERN Mobility Centre by Martin Steinacher, Director for Finance and Human Resources, and Lluis Miralles, Head of the SMB department. CERN’s new Mobility Centre, on the car park next to the Globe of Science and Innovation was officially opened on Tuesday, 22 March. The centre brings together all of CERN’s transport options in a single location. "Our aim is to create an intermodal hub where CERN users and personnel can switch from one mode of transport to another, and from CERN transport to public transport," explains Lluis Miralles, head of the Site Management and Buildings (SMB) department. The Mobility Centre incorporates the CERN bike and car rental services, the self-service car- and bike-sharing schemes, and SIXT car rental facilities (for long-distance journeys). It is located right ne...

  10. Estimating the sustainability of hubs

    NARCIS (Netherlands)

    Lieshout, R.; Zuidberg, J.; Veldhuis, J.

    2008-01-01

    Several airports in the world are or will be confronted with capacity problems in the near future. As a result of this congestion, many airports will face a selectivity problem: which traffic segments must be accommodated and which segments are less crucial? At hub airports there is generally one

  11. Beijing: Next International Financial Hub?

    Institute of Scientific and Technical Information of China (English)

    Li Zhen

    2008-01-01

    @@ Beijing's new financial dream On May 5,the Beijing Municipal Government released a notice regarding its plans to spur the financial industry,vowing to put forth a strong effort to become the national financial decision-making center,financial management center and financial information and services center,and formally announcing its ambitious aspiration to become a financial hub with international influence.

  12. Solving Hub Network Problem Using Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Mursyid Hasan Basri

    2012-01-01

    Full Text Available This paper addresses a network problem that described as follows. There are n ports that interact, and p of those will be designated as hubs. All hubs are fully interconnected. Each spoke will be allocated to only one of available hubs. Direct connection between two spokes is allowed only if they are allocated to the same hub. The latter is a distinct characteristic that differs it from pure hub-and-spoke system. In case of pure hub-and-spoke system, direct connection between two spokes is not allowed. The problem is where to locate hub ports and to which hub a spoke should be allocated so that total transportation cost is minimum. In the first model, there are some additional aspects are taken into consideration in order to achieve a better representation of the problem. The first, weekly service should be accomplished. Secondly, various vessel types should be considered. The last, a concept of inter-hub discount factor is introduced. Regarding the last aspect, it represents cost reduction factor at hub ports due to economies of scale. In practice, it is common that the cost rate for inter-hub movement is less than the cost rate for movement between hub and origin/destination. In this first model, inter-hub discount factor is assumed independent with amount of flows on inter-hub links (denoted as flow-independent discount policy. The results indicated that the patterns of enlargement of container ship size, to some degree, are similar with those in Kurokawa study. However, with regard to hub locations, the results have not represented the real practice. In the proposed model, unsatisfactory result on hub locations is addressed. One aspect that could possibly be improved to find better hub locations is inter-hub discount factor. Then inter-hub discount factor is assumed to depend on amount of inter-hub flows (denoted as flow-dependent discount policy. There are two discount functions examined in this paper. Both functions are characterized by

  13. Solving Hub Network Problem Using Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Mursyid Hasan Basri

    2012-01-01

    Full Text Available This paper addresses a network problem that described as follows. There are n ports that interact, and p of those will be designated as hubs. All hubs are fully interconnected. Each spoke will be allocated to only one of available hubs. Direct connection between two spokes is allowed only if they are allocated to the same hub. The latter is a distinct characteristic that differs it from pure hub-and-spoke system. In case of pure hub-and-spoke system, direct connection between two spokes is not allowed. The problem is where to locate hub ports and to which hub a spoke should be allocated so that total transportation cost is minimum. In the first model, there are some additional aspects are taken into consideration in order to achieve a better representation of the problem. The first, weekly service should be accomplished. Secondly, various vessel types should be considered. The last, a concept of inter-hub discount factor is introduced. Regarding the last aspect, it represents cost reduction factor at hub ports due to economies of scale. In practice, it is common that the cost rate for inter-hub movement is less than the cost rate for movement between hub and origin/destination. In this first model, inter-hub discount factor is assumed independent with amount of flows on inter-hub links (denoted as flow-independent discount policy. The results indicated that the patterns of enlargement of container ship size, to some degree, are similar with those in Kurokawa study. However, with regard to hub locations, the results have not represented the real practice. In the proposed model, unsatisfactory result on hub locations is addressed. One aspect that could possibly be improved to find better hub locations is inter-hub discount factor. Then inter-hub discount factor is assumed to depend on amount of inter-hub flows (denoted as flow-dependent discount policy. There are two discount functions examined in this paper. Both functions are characterized by

  14. PolarHub: A Global Hub for Polar Data Discovery

    Science.gov (United States)

    Li, W.

    2014-12-01

    This paper reports the outcome of a NSF project in developing a large-scale web crawler PolarHub to discover automatically the distributed polar dataset in the format of OGC web services (OWS) in the cyberspace. PolarHub is a machine robot; its goal is to visit as many webpages as possible to find those containing information about polar OWS, extract this information and store it into the backend data repository. This is a very challenging task given huge data volume of webpages on the Web. Three unique features was introduced in PolarHub to make it distinctive from earlier crawler solutions: (1) a multi-task, multi-user, multi-thread support to the crawling tasks; (2) an extensive use of thread pool and Data Access Object (DAO) design patterns to separate persistent data storage and business logic to achieve high extendibility of the crawler tool; (3) a pattern-matching based customizable crawling algorithm to support discovery of multi-type geospatial web services; and (4) a universal and portable client-server communication mechanism combining a server-push and client pull strategies for enhanced asynchronous processing. A series of experiments were conducted to identify the impact of crawling parameters to the overall system performance. The geographical distribution pattern of all PolarHub identified services is also demonstrated. We expect this work to make a major contribution to the field of geospatial information retrieval and geospatial interoperability, to bridge the gap between data provider and data consumer, and to accelerate polar science by enhancing the accessibility and reusability of adequate polar data.

  15. The once & future repository, HKU's Scholars Hub

    OpenAIRE

    Palmer, DT; Castro, P.; Bollini, A; Mennielli, M

    2015-01-01

    The HKU Scholars Hub (the Hub) began service as a traditional institutional repository of The University of Hong Kong (HKU). However this format was not compelling to HKU researchers. Fortunately a subsequent reformation of the HKU statement on university mission and vision infused new life and purpose into the project. Over the next five years, in partnership with the Italian University Consortium, Cineca, the HKU Libraries transformed the Hub from an IR to a Current Research Information ...

  16. On GitHub's Programming Languages

    OpenAIRE

    2016-01-01

    GitHub is the most widely used social, distributed version control system. It has around 10 million registered users and hosts over 16 million public repositories. Its user base is also very active as GitHub ranks in the top 100 Alexa most popular websites. In this study, we collect GitHub's state in its entirety. Doing so, allows us to study new aspects of the ecosystem. Although GitHub is the home to millions of users and repositories, the analysis of users' activity time-series reveals tha...

  17. The ASPEC teeter: price/performance improvement of existing wind turbine technology by using a revolutionary concept

    Energy Technology Data Exchange (ETDEWEB)

    Doorenspleet, F. [Aerpac Special Products B.V., Amelo (Netherlands); Prats, J. [Ecotecnia S. Coop, Barcelona (Spain); Hagg, F. [Stork Product Engineering B.V. Amsterdam (Netherlands)

    1996-12-31

    Improvement of the price/performance ratio of wind turbines is essential if wind energy is to be taken seriously in the world energy market in the coming century. The key to improvement of the price/performance ratio lies in the minimisation of loads by inexpensive means, at a simultaneous increase in annual production of the wind turbine. On basis of the NOVEM/CEC Flexhat project, this design project is a first step towards commercialisation of flexible rotor technology. The goal of the project was to redesign an existing stall-regulated wind turbine to improve the original price/performance ratio by 20%. This goal has been reached by the use of a larger, two-bladed rotor with elastomeric tester, variable speed drivetrain and fast active tip pitch control with an advanced peakshaving function. The project has been sponsored by the European Commission under contract nr. Jou2CT93-0281. (author)

  18. Experimental and theoretical characterization of acoustic noise from a 7.6 m diameter yaw controlled teetered rotor wind turbine

    Energy Technology Data Exchange (ETDEWEB)

    Moroz, E. [Univ. of Texas at El Paso, Dept. of Mechanical and Industrial Engineering, El Paso, TX (United States)

    1997-12-31

    An experimental investigation into the acoustic noise from a small (7.6 m diameter) teetered rotor wind turbine, set at various yaw angles up to 90 degrees of yaw, was conducted. The results revealed a 1/3 octave spectra which was dominated by a broad peak in the higher frequency range, at all yaw angles investigated. This prompted a theoretical investigation to reveal the mechanisms producing the dominant feature in the experimentally obtained noise spectra and resulted in the development of a wind turbine aerodynamic noise prediction coce, WTNOISE. The location near busy roads and the relatively rough terrain of the wind test site caused difficulties in obtaining useful noise spectral information below 500Hz. However, sufficiently good data was obtained above 500Hz to clearly show a dominant `hump` in the spectrum, centered between 3000 and 4000Hz. Although the local Reynolds number for the blade elements was around 500,000 and one might expect Laminar flow over a significant portion of the blade, the data did not match the noise spectra predicted when Laminar flow was assumed. Given the relatively poor surface quality of the rotor blades and the high turbulence of the test site it was therefore assumed that the boundary layer on the blade may have tripped relatively early and that the turbulent flow setting should be used. This assumption led to a much better correlation between experiment and predictions. The WTNOISE code indicated that the broad peak in the spectrum was most likely caused by trailing edge bluntness noise. Unfortunately time did not allow for modifications to the trailing edge to be investigated. (au)

  19. Virtual Campus Hub technical evaluation report

    DEFF Research Database (Denmark)

    Vercoulen, Frank; Badger, Merete; Monaco, Lucio;

    This report describes and discusses the technical achievements of the Virtual Campus Hub project and formulates a brief agenda for the future.......This report describes and discusses the technical achievements of the Virtual Campus Hub project and formulates a brief agenda for the future....

  20. Logistics hubs: an integration of transport infrastructure

    CSIR Research Space (South Africa)

    Botha, M

    2008-07-01

    Full Text Available Logistics hubs are very well established internationally and many examples exist where these have been successfully built and implemented. This success have lead to the proliferation of such hubs and in South Africa there are many "decision makers...

  1. Hub discovery in partial correlation graphical models

    CERN Document Server

    Hero, Alfred

    2011-01-01

    This paper treats the problem of screening a p-variate sample for strongly and multiply connected vertices in the partial correlation graph associated with the the partial correlation matrix of the sample. This problem, called hub screening, is important in many applications ranging from network security to computational biology to finance to social networks. In the area of network security, a node that becomes a hub of high correlation with neighboring nodes might signal anomalous activity such as a coordinated flooding attack. In the area of computational biology the set of hubs of a gene expression correlation graph can serve as potential targets for drug treatment to block a pathway or modulate host response. In the area of finance a hub might indicate a vulnerable financial instrument or sector whose collapse might have major repercussions on the market. In the area of social networks a hub of observed interactions between criminal suspects could be an influential ringleader. The techniques and theory pr...

  2. Dynamic hubs show competitive and static hubs non-competitive regulation of their interaction partners.

    Directory of Open Access Journals (Sweden)

    Apurv Goel

    Full Text Available Date hub proteins have 1 or 2 interaction interfaces but many interaction partners. This raises the question of whether all partner proteins compete for the interaction interface of the hub or if the cell carefully regulates aspects of this process? Here, we have used real-time rendering of protein interaction networks to analyse the interactions of all the 1 or 2 interface hubs of Saccharomyces cerevisiae during the cell cycle. By integrating previously determined structural and gene expression data, and visually hiding the nodes (proteins and their edges (interactions during their troughs of expression, we predict when interactions of hubs and their partners are likely to exist. This revealed that 20 out of all 36 one- or two- interface hubs in the yeast interactome fell within two main groups. The first was dynamic hubs with static partners, which can be considered as 'competitive hubs'. Their interaction partners will compete for the interaction interface of the hub and the success of any interaction will be dictated by the kinetics of interaction (abundance and affinity and subcellular localisation. The second was static hubs with dynamic partners, which we term 'non-competitive hubs'. Regulatory mechanisms are finely tuned to lessen the presence and/or effects of competition between the interaction partners of the hub. It is possible that these regulatory processes may also be used by the cell for the regulation of other, non-cell cycle processes.

  3. Innovation Hub How-To

    DEFF Research Database (Denmark)

    Berger, Andreas; Brem, Alexander

    2016-01-01

    Firms around the world are eager to replicate the successes of enterprises that have established innovation labs in California's Silicon Valley. An analysis of four leading US companies that have set up idea incubators in the Valley—Xerox, Apple, Google, and Cisco—point to eight factors for succe...... disruptive over incremental innovation, and being patient. Regardless of where an innovation hub is established, the key to success lies in hiring creative, intrinsically motivated staff and then giving them the freedom to do what they do best.......Firms around the world are eager to replicate the successes of enterprises that have established innovation labs in California's Silicon Valley. An analysis of four leading US companies that have set up idea incubators in the Valley—Xerox, Apple, Google, and Cisco—point to eight factors for success...... in establishing an innovative environment: carefully considering the decision to set up such a center, hiring the right people, designing a framework for effective output, creating a buffer from bureaucratic distractions, securing a leader to champion the effort, focusing on business outcomes, fostering...

  4. Zoning Districts - Volusia County HUB Zones

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Historically Underutilized Business (HUB) Zones in Volusia County. Go to http://www.sba.gov/hubzone or contact the Department of Economic Development (386) 248-8048...

  5. Motor coordination: a local hub for coordination.

    Science.gov (United States)

    Calabrese, Ronald L

    2014-03-31

    A local interneuron of a crayfish central pattern generator serves as a hub that integrates ascending and descending coordinating information and passes it on to a local oscillatory microcircuit to coordinate a series of segmental appendages known as swimmerets.

  6. Contextual Hub Analysis Tool (CHAT): A Cytoscape app for identifying contextually relevant hubs in biological networks

    Science.gov (United States)

    Wiencko, Heather L.; Bernal-Llinares, Manuel; Bryan, Kenneth; Lynn, David J.

    2016-01-01

    Highly connected nodes (hubs) in biological networks are topologically important to the structure of the network and have also been shown to be preferentially associated with a range of phenotypes of interest. The relative importance of a hub node, however, can change depending on the biological context. Here, we report a Cytoscape app, the Contextual Hub Analysis Tool (CHAT), which enables users to easily construct and visualize a network of interactions from a gene or protein list of interest, integrate contextual information, such as gene expression or mass spectrometry data, and identify hub nodes that are more highly connected to contextual nodes (e.g. genes or proteins that are differentially expressed) than expected by chance. In a case study, we use CHAT to construct a network of genes that are differentially expressed in Dengue fever, a viral infection. CHAT was used to identify and compare contextual and degree-based hubs in this network. The top 20 degree-based hubs were enriched in pathways related to the cell cycle and cancer, which is likely due to the fact that proteins involved in these processes tend to be highly connected in general. In comparison, the top 20 contextual hubs were enriched in pathways commonly observed in a viral infection including pathways related to the immune response to viral infection. This analysis shows that such contextual hubs are considerably more biologically relevant than degree-based hubs and that analyses which rely on the identification of hubs solely based on their connectivity may be biased towards nodes that are highly connected in general rather than in the specific context of interest. Availability: CHAT is available for Cytoscape 3.0+ and can be installed via the Cytoscape App Store ( http://apps.cytoscape.org/apps/chat). PMID:27853512

  7. Contextual Hub Analysis Tool (CHAT): A Cytoscape app for identifying contextually relevant hubs in biological networks.

    Science.gov (United States)

    Muetze, Tanja; Goenawan, Ivan H; Wiencko, Heather L; Bernal-Llinares, Manuel; Bryan, Kenneth; Lynn, David J

    2016-01-01

    Highly connected nodes (hubs) in biological networks are topologically important to the structure of the network and have also been shown to be preferentially associated with a range of phenotypes of interest. The relative importance of a hub node, however, can change depending on the biological context. Here, we report a Cytoscape app, the Contextual Hub Analysis Tool (CHAT), which enables users to easily construct and visualize a network of interactions from a gene or protein list of interest, integrate contextual information, such as gene expression or mass spectrometry data, and identify hub nodes that are more highly connected to contextual nodes (e.g. genes or proteins that are differentially expressed) than expected by chance. In a case study, we use CHAT to construct a network of genes that are differentially expressed in Dengue fever, a viral infection. CHAT was used to identify and compare contextual and degree-based hubs in this network. The top 20 degree-based hubs were enriched in pathways related to the cell cycle and cancer, which is likely due to the fact that proteins involved in these processes tend to be highly connected in general. In comparison, the top 20 contextual hubs were enriched in pathways commonly observed in a viral infection including pathways related to the immune response to viral infection. This analysis shows that such contextual hubs are considerably more biologically relevant than degree-based hubs and that analyses which rely on the identification of hubs solely based on their connectivity may be biased towards nodes that are highly connected in general rather than in the specific context of interest.

  8. Collaborative Data Analytics with DataHub.

    Science.gov (United States)

    Bhardwaj, Anant; Karger, David; Subramanyam, Harihar; Deshpande, Amol; Madden, Sam; Wu, Eugene; Elmore, Aaron; Parameswaran, Aditya; Zhang, Rebecca

    2015-08-01

    While there have been many solutions proposed for storing and analyzing large volumes of data, all of these solutions have limited support for collaborative data analytics, especially given the many individuals and teams are simultaneously analyzing, modifying and exchanging datasets, employing a number of heterogeneous tools or languages for data analysis, and writing scripts to clean, preprocess, or query data. We demonstrate DataHub, a unified platform with the ability to load, store, query, collaboratively analyze, interactively visualize, interface with external applications, and share datasets. We will demonstrate the following aspects of the DataHub platform: (a) flexible data storage, sharing, and native versioning capabilities: multiple conference attendees can concurrently update the database and browse the different versions and inspect conflicts; (b) an app ecosystem that hosts apps for various data-processing activities: conference attendees will be able to effortlessly ingest, query, and visualize data using our existing apps; (c) thrift-based data serialization permits data analysis in any combination of 20+ languages, with DataHub as the common data store: conference attendees will be able to analyze datasets in R, Python, and Matlab, while the inputs and the results are still stored in DataHub. In particular, conference attendees will be able to use the DataHub notebook - an IPython-based notebook for analyzing data and storing the results of data analysis.

  9. Supervised hub-detection for brain connectivity

    Science.gov (United States)

    Kasenburg, Niklas; Liptrot, Matthew; Reislev, Nina Linde; Garde, Ellen; Nielsen, Mads; Feragen, Aasa

    2016-03-01

    A structural brain network consists of physical connections between brain regions. Brain network analysis aims to find features associated with a parameter of interest through supervised prediction models such as regression. Unsupervised preprocessing steps like clustering are often applied, but can smooth discriminative signals in the population, degrading predictive performance. We present a novel hub-detection optimized for supervised learning that both clusters network nodes based on population level variation in connectivity and also takes the learning problem into account. The found hubs are a low-dimensional representation of the network and are chosen based on predictive performance as features for a linear regression. We apply our method to the problem of finding age-related changes in structural connectivity. We compare our supervised hub-detection (SHD) to an unsupervised hub-detection and a linear regression using the original network connections as features. The results show that the SHD is able to retain regression performance, while still finding hubs that represent the underlying variation in the population. Although here we applied the SHD to brain networks, it can be applied to any network regression problem. Further development of the presented algorithm will be the extension to other predictive models such as classification or non-linear regression.

  10. Hub Status and Indexation of Container Ports

    Directory of Open Access Journals (Sweden)

    Yong-An Park

    2015-06-01

    This study develops two sub-indexes of port classification and capacity, and combines cases of these two sub-indexes into various types in order to find a proper port hub index. The paper demonstrates how different types of port hub index are useful measurements for evaluating outputs and inputs of container ports. In a case analysis we show that the indexes of period variables and lagged variables have more explanatory power with regard to changes of port throughputs and high correlation with inputs.

  11. Exploring hubness in Regional Trade Agreements

    NARCIS (Netherlands)

    Vaal, A. de

    2016-01-01

    In the plethora of Regional Trade Agreements (RTAs) some countries take in a more central position than others in the sense that some countries are much more engaged with other countries through RTAs. Furthermore, the position of some countries is that of a hub: they have (many) trade

  12. Hub location problems in transportation networks

    DEFF Research Database (Denmark)

    Gelareh, Shahin; Nickel, Stefan

    2011-01-01

    In this paper we propose a 4-index formulation for the uncapacitated multiple allocation hub location problem tailored for urban transport and liner shipping network design. This formulation is very tight and most of the tractable instances for MIP solvers are optimally solvable at the root node....... also introduce fixed cost values for Australian Post (AP) dataset....

  13. Optimising steel hub location in Thailand

    Directory of Open Access Journals (Sweden)

    Sakaradhorn Boontaveeyuwat

    2012-11-01

    Full Text Available The optimal location of a steel hub in Thailand was analysed by applying aspecific research methodology designed to evaluate locations near the seaports. The growth of Thailand’s steel industry has become a centre of attention in the last decade, resulting in substantial efforts to form a distribution service centre to minimise the logistic costs associated with handling large steel flows in the future. The main analysis of the steel hublocation focused on areas situated near Laem Cha Bang, Map Ta Phut and Prachuab ports since these top three ports are considered important in terms of their steel throughput in Thailand. The transport costs associated with the shipment and inland transport together with port tariffs were calculated for the proposed scenarios of steel hub establishment andthese were compared with the existing situation without steel hub. The findings showed that a steel hub located near Laem Cha Bang port was the optimal option involving a saving of 9.4% on the total system costs incurred under the existing situation.

  14. A State Cyber Hub Operations Framework

    Science.gov (United States)

    2016-06-01

    level cyber operations from state information technology (IT) and network infrastructure to hospitals , commercial banking, and manufacturing the...tools - TTPs necessary to operate and maintain Authoritative Data Repository for operational related artifacts . - Monitor and report on operations...development of Data Repository structures to enable storage of Cyber Hub related artifacts . - Provides Technical input to Business Case Analyses (BCAs

  15. Constructing Hongqiao Hub and Serving Regional Economy:Planning and Operation of Hongqiao Comprehensive Transportation Hub

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Taking Hongqiao Integrated Transportation Hub Project as a case, this paper introduces its origin, orientation, development programming, planning and design, road planning, information system planning, air-rail integrated transportation planning, disaster prevention planning, and so on.

  16. Over-heated Investment in Aluminum Hub Industry

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正>Aluminum hub is one of typical products with the comparative advantages.China’s aluminum hub industry is very competitive.In recent years,the value of export for the aluminum hub soared,increasing from USD130 millions in 1999 up to nearly USD1 billion in 2004.The main exporter are Wanfeng Auto Holding Group,Shanghai Fervent Alloy Wheel MFG Co.,Ltd.,Nanhai Zhongnan Aluminum Co., Ltd.,Taian Huatai Aluminum Hub Co.,Ltd.

  17. Southwest Regional Climate Hub and California Subsidiary Hub assessment of climate change vulnerability and adaptation and mitigation strategies

    Science.gov (United States)

    Emile Elias; Caiti Steele; Kris Havstad; Kerri Steenwerth; Jeanne Chambers; Helena Deswood; Amber Kerr; Albert Rango; Mark Schwartz; Peter Stine; Rachel Steele

    2015-01-01

    This report is a joint effort of the Southwest Regional Climate Hub and the California Subsidiary Hub (Sub Hub). The Southwest Regional Climate Hub covers Arizona, California, Hawai‘i and the U.S. affiliated Pacific Islands, Nevada, New Mexico, and Utah and contains vast areas of western rangeland, forests, and high-value specialty crops (Figure 1). The California Sub...

  18. Extension of Goldstein's circulation function for optimal rotors with hub

    DEFF Research Database (Denmark)

    Okulov, Valery; Sørensen, Jens Nørkær; Shen, Wen Zhong

    2016-01-01

    The aerodynamic interaction or interference between rotor blades and hub body is usually very complicated, but some useful simplifications can be made by considering the hub with an infinite cylinder. Various attempts to find the optimum distribution of circulation by the lifting vortex lines...... method have been previously proposed to describe the blade interaction with the hub modeled by the infinite cylinder. In this case, the ideal distribution of bound circulation on the rotor blades is such that the shed vortex system in the hub-area is a set of helicoidal vortex sheets moving uniformly...... at the nose-area of the semi-infinite hub....

  19. Developmental Changes in Brain Network Hub Connectivity in Late Adolescence.

    Science.gov (United States)

    Baker, Simon T E; Lubman, Dan I; Yücel, Murat; Allen, Nicholas B; Whittle, Sarah; Fulcher, Ben D; Zalesky, Andrew; Fornito, Alex

    2015-06-17

    The human brain undergoes substantial development throughout adolescence and into early adulthood. This maturational process is thought to include the refinement of connectivity between putative connectivity hub regions of the brain, which collectively form a dense core that enhances the functional integration of anatomically distributed, and functionally specialized, neural systems. Here, we used longitudinal diffusion magnetic resonance imaging to characterize changes in connectivity between 80 cortical and subcortical anatomical regions over a 2 year period in 31 adolescents between the ages of 15 and 19 years. Connectome-wide analysis indicated that only a small subset of connections showed evidence of statistically significant developmental change over the study period, with 8% and 6% of connections demonstrating decreased and increased structural connectivity, respectively. Nonetheless, these connections linked 93% and 90% of the 80 regions, respectively, pointing to a selective, yet anatomically distributed pattern of developmental changes that involves most of the brain. Hub regions showed a distinct tendency to be highly connected to each other, indicating robust "rich-club" organization. Moreover, connectivity between hubs was disproportionately influenced by development, such that connectivity between subcortical hubs decreased over time, whereas frontal-subcortical and frontal-parietal hub-hub connectivity increased over time. These findings suggest that late adolescence is characterized by selective, yet significant remodeling of hub-hub connectivity, with the topological organization of hubs shifting emphasis from subcortical hubs in favor of an increasingly prominent role for frontal hub regions.

  20. Spatial Economic Hubs and State Power

    Institute of Scientific and Technical Information of China (English)

    Xuan Xingzhang; Huang Jing

    2008-01-01

    The paper seeks to analyze the rise of state power in the light of spatial economic shifts and examines the historical context of China's rise and challenges facing it. In world history, only countries that were spatial economic hubs have been able to enjoy prosperity over centuries. China is not yet such a country, despite its persistent efforts. Nor is China likely to become an economic hub in the foreseeable future. China is under mounting pressure from new economic demands posed by shifts in the geo-economic status of the U.S.. The fact that the global economy thrives along coastlines also causes problems for China, a country with a long coastline and a vast hinterland, creating rifts between northern and southern China, central and local governments, and different provinces. All these factors might well hinder China's development in the future.

  1. Topographic hub maps of the human structural neocortical network.

    Directory of Open Access Journals (Sweden)

    Emil H J Nijhuis

    Full Text Available Hubs within the neocortical structural network determined by graph theoretical analysis play a crucial role in brain function. We mapped neocortical hubs topographically, using a sample population of 63 young adults. Subjects were imaged with high resolution structural and diffusion weighted magnetic resonance imaging techniques. Multiple network configurations were then constructed per subject, using random parcellations to define the nodes and using fibre tractography to determine the connectivity between the nodes. The networks were analysed with graph theoretical measures. Our results give reference maps of hub distribution measured with betweenness centrality and node degree. The loci of the hubs correspond with key areas from known overlapping cognitive networks. Several hubs were asymmetrically organized across hemispheres. Furthermore, females have hubs with higher betweenness centrality and males have hubs with higher node degree. Female networks have higher small-world indices.

  2. Extension of Goldstein's circulation function for optimal rotors with hub

    Science.gov (United States)

    Okulov, V. L.; Sørensen, J. N.; Shen, W. Z.

    2016-09-01

    The aerodynamic interaction or interference between rotor blades and hub body is usually very complicated, but some useful simplifications can be made by considering the hub with an infinite cylinder. Various attempts to find the optimum distribution of circulation by the lifting vortex lines method have been previously proposed to describe the blade interaction with the hub modeled by the infinite cylinder. In this case, the ideal distribution of bound circulation on the rotor blades is such that the shed vortex system in the hub-area is a set of helicoidal vortex sheets moving uniformly as if rigid, exactly as in the case where there is no influence of the streamtube deformations by the central hub-body. In the present investigation, we consider a more specific problem of the rotor-hub interaction where the initial flow streamtubes and the rotor slipstream submitted strong deformations at the nose-area of the semi-infinite hub.

  3. Ranking hubs and authorities using matrix functions

    OpenAIRE

    2012-01-01

    The notions of subgraph centrality and communicability, based on the exponential of the adjacency matrix of the underlying graph, have been effectively used in the analysis of undirected networks. In this paper we propose an extension of these measures to directed networks, and we apply them to the problem of ranking hubs and authorities. The extension is achieved by bipartization, i.e., the directed network is mapped onto a bipartite undirected network with twice as many nodes in order to ob...

  4. Developing Istanbul into a Regional Business Hub

    Science.gov (United States)

    2004-12-01

    beds). Every year Istanbul hosts people from all around the world for international summits, conferences, film and music festivals and sports...Kong, Taiwan, Malaysia , Thailand, and the Philippines are positioning themselves to be logistics hubs. On the other hand, in Eastern Europe; Czech...close to nearby major markets of the world, are only some of Turkey’s many advantages. 2. Istanbul Throughout history , Istanbul has been a city at the

  5. Biaxial wheel/hub test facility. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, G.; Grubisic, V. [eds.

    2000-07-01

    The 4{sup th} meeting aims to exchange the experience and knowledge of engineers during several presentations and discussions about new developments required for a reliable, time and cost reducing validation of the wheel/hub assembly. Tremendous development of the wheel performance, described by the ratio of the rated load (kg) versus the wheel weight (kg) had taken place during the last 5000 years. Starting from the ratio of 3 for wooden 2-piece-disc-wheels in Mesopotamia it needed nearly 1000 years to increase the ratio to approx 5 at light-weight spoke wheels for fighting carriages, found in the grave of king Tutenchamon in Egypt. Modern light alloy wheels of commercial vehicles reach values up to 160 kg/kg. Additionally the comlex design of the modern systems for cars and commercial vehicles comprising wheel, brake, hub, bearing, spindle and hub carrier, including different materials and their treatment, fasteners, press-fits, require an appropriate testing procedure. The variable loading conditions, caused by operational wheel forces, brake and torque moments including heating, may result in changing tolerances and press-fits during operation and consequently in different damage mechanisms. This can be simulated in the Biaxial Wheel Test Machine, whereby corresponding load programs are necessary. An overview about all biaxial test machines in usage at the end of 1999 is shown in the introduction. The total number is 17 for cars, 7 for commercial vehicles and 1 for trains. The six presentations of this meeting were consequently concentrated on: (a) recommendations for a standardization of load programs of the German Wheel Committee, (b) the simulation of brake and torque events and (c) the possibility for a numerical stress analyses and fatigue life assessment. (orig./AKF)

  6. Supervised hub-detection for brain connectivity

    DEFF Research Database (Denmark)

    Kasenburg, Niklas; Liptrot, Matthew George; Reislev, Nina Linde

    2016-01-01

    A structural brain network consists of physical connections between brain regions. Brain network analysis aims to find features associated with a parameter of interest through supervised prediction models such as regression. Unsupervised preprocessing steps like clustering are often applied......-detection and a linear regression using the original network connections as features. The results show that the SHD is able to retain regression performance, while still finding hubs that represent the underlying variation in the population. Although here we applied the SHD to brain networks, it can be applied to any...

  7. An Introduction to Version Control Using GitHub Desktop

    Directory of Open Access Journals (Sweden)

    Daniel van Strien

    2016-06-01

    Full Text Available In this lesson you will be introduced to the basics of version control, understand why it is useful and implement basic version control for a plain text document using GitHub Desktop. By the end of this lesson you should understand: * what version control is and why it can be useful * the differences between Git and GitHub * how to implement version control using ‘GitHub Desktop,’ a Graphical User Interface for GitHub * be aware of other resources that will help you implement version control in your academic writing

  8. An Introduction to Version Control Using GitHub Desktop

    OpenAIRE

    Daniel van Strien

    2016-01-01

    In this lesson you will be introduced to the basics of version control, understand why it is useful and implement basic version control for a plain text document using GitHub Desktop. By the end of this lesson you should understand: * what version control is and why it can be useful * the differences between Git and GitHub * how to implement version control using ‘GitHub Desktop,’ a Graphical User Interface for GitHub * be aware of other resources that will help you imple...

  9. Liner Shipping Hub Network Design in a Competitive Environment

    DEFF Research Database (Denmark)

    Gelareh, Shahin; Nickel, Stefan; Pisinger, David

    A new mixed integer programming formulation is proposed for hub-and-spoke network design in a competitive environment. It addresses competition between a newcomer liner service provider and an alliance, both operating on hub-and-spoke networks. The newcomer company maximizes its market share...

  10. Liner shipping hub network design in a competitive environment

    DEFF Research Database (Denmark)

    Gelareh, Shahin; Nickel, Stefan; Pisinger, David

    2010-01-01

    A mixed integer programming formulation is proposed for hub-and-spoke network design in a competitive environment. It addresses the competition between a newcomer liner service provider and an existing dominating operator, both operating on hub-and-spoke networks. The newcomer company maximizes its...

  11. International Education Hubs: Collaboration for Competitiveness and Sustainability

    Science.gov (United States)

    Knight, Jane

    2014-01-01

    This chapter focuses on the development of education hubs, a recent phenomenon in international higher education. Three models of hubs are examined in relation to the forces, risks, and opportunities of globalization and how local and international collaborations are essential for both global competitiveness and sustainability.

  12. Soft Power and Cultural Diplomacy: Emerging Education Hubs in Asia

    Science.gov (United States)

    Lee, Jack T.

    2015-01-01

    Several education hubs have emerged in Asia and the Middle East in recent years with a specific focus on cross-border higher education. Through considerable efforts in policy planning and generous funding, these hubs aim to transform a country or city into an eminent destination for education, research, and training. The inherent design of these…

  13. Optimal Model and Solution of Railway Hub Shift Working Plan

    Institute of Scientific and Technical Information of China (English)

    He Shiwei; Zhu Songnian; Lin Boliang

    1996-01-01

    Aiming at decreasing the hub transportation costs, a railway hub shift working plan in terms of multicommodity network flow model is set up for considering the coordination of freight working, train working and locomotive working plans. The solution and the calculating results are also introduced.

  14. Phased arrays: inline flow line hub inspection using phased arrays

    NARCIS (Netherlands)

    Bloom, J.G.P.; Chougrani, K.; Rundberg, H.; Oldenziel, G.; Deleye, X.; Martina, Q.

    2011-01-01

    The feasibility of the inspection of flow line hubs using the phased array technique was investigated to determine the surface area of the seal area degraded by corrosion. A clean model of the hub was simulated to gain insight into the geometrical echoes and to determine the area covered by the ultr

  15. A versatile framework for cooperative hub network development

    NARCIS (Netherlands)

    Cruijssen, F.C.A.M.; Borm, P.; Dullaert, W.; Hamers, H.

    2010-01-01

    This paper introduces a framework for cooperative hub network development. Building a joint physical hub for the transshipment of goods is expensive and, therefore, involves considerable risks for cooperating companies. In a practical setting, it is unlikely that an entire network will be built at o

  16. Education Hubs: A Fad, a Brand, an Innovation?

    Science.gov (United States)

    Knight, Jane

    2011-01-01

    The last decade has seen significant changes in all aspects of internationalization but most dramatically in the area of education and research moving across national borders. The most recent developments are education hubs. The term "education hub" is being used by countries who are trying to build a critical mass of local and foreign…

  17. Soft Power and Cultural Diplomacy: Emerging Education Hubs in Asia

    Science.gov (United States)

    Lee, Jack T.

    2015-01-01

    Several education hubs have emerged in Asia and the Middle East in recent years with a specific focus on cross-border higher education. Through considerable efforts in policy planning and generous funding, these hubs aim to transform a country or city into an eminent destination for education, research, and training. The inherent design of these…

  18. Climate programs update: USDA Southwest Regional Climate Hub update

    Science.gov (United States)

    PROGRAM OVERVIEW: The overarching goal of the USDA SW Climate Hub is to assist farmers, ranchers and foresters in addressing the effects of climate change including prolonged drought, increased insect outbreaks and severe wildfires. In the first year of operations, the SW Climate Hub (est. Februa...

  19. Liner shipping hub network design in a competitive environment

    DEFF Research Database (Denmark)

    Gelareh, Shahin; Nickel, Stefan; Pisinger, David

    2010-01-01

    A mixed integer programming formulation is proposed for hub-and-spoke network design in a competitive environment. It addresses the competition between a newcomer liner service provider and an existing dominating operator, both operating on hub-and-spoke networks. The newcomer company maximizes i...

  20. International Education Hubs: Collaboration for Competitiveness and Sustainability

    Science.gov (United States)

    Knight, Jane

    2014-01-01

    This chapter focuses on the development of education hubs, a recent phenomenon in international higher education. Three models of hubs are examined in relation to the forces, risks, and opportunities of globalization and how local and international collaborations are essential for both global competitiveness and sustainability.

  1. The 4 Pi Sky Transient Alerts Hub

    CERN Document Server

    Staley, Tim D

    2016-01-01

    We introduce the 4 Pi Sky 'hub', a collection of open data-services and underlying software packages built for rapid, fully automated reporting and response to astronomical transient alerts. These packages build on the mature 'VOEvent' standardized message-format, and aim to provide a decentralized and open infrastructure for handling transient alerts. In particular we draw attention to the initial release of voeventdb, an archive and remote-query service that allows astronomers to make historical queries about transient alerts. By employing spatial filters and web-of-citation lookups, voeventdb enables cross-matching of transient alerts to bring together data from multiple sources, as well as providing a point of reference when planning new follow-up campaigns. We also highlight the recent addition of optical-transient feeds from the ASASSN and GAIA projects to our VOEvent distribution stream. Both the source-code and deployment-scripts which implement these services are freely available and permissively lic...

  2. On the Predictability of Hub Height Winds

    DEFF Research Database (Denmark)

    Draxl, Caroline

    Wind energy is a major source of power in over 70 countries across the world, and the worldwide share of wind energy in electricity consumption is growing. The introduction of signicant amounts of wind energy into power systems makes accurate wind forecasting a crucial element of modern electrical...... grids. These systems require forecasts with temporal scales of tens of minutes to a few days in advance at wind farm locations. Traditionally these forecasts predict the wind at turbine hub heights; this information is then converted by transmission system operators and energy companies into predictions...... of power output at wind farms. Since the power available in the wind is proportional to the wind speed cubed, even small wind forecast errors result in large power prediction errors. Accurate wind forecasts are worth billions of dollars annually; forecast improvements will result in reduced costs...

  3. Location of Urban Logistic Terminals as Hub Location Problem

    Directory of Open Access Journals (Sweden)

    Jasmina Pašagić Škrinjar

    2012-09-01

    Full Text Available In this paper the problems of locating urban logistic terminals are studied as hub location problems that due to a large number of potential nodes in big cities belong to hard non-polynomial problems, the so-called NP-problems. The hub location problems have found wide application in physical planning of transport and telecommunication systems, especially systems of fast delivery, networks of logistic and distribution centres and cargo traffic terminals of the big cities, etc. The paper defines single and multiple allocations and studies the numerical examples. The capacitated single allocation hub location problems have been studied, with the provision of a mathematical model of selecting the location for the hubs on the network. The paper also presents the differences in the possibilities of implementing the exact and heuristic methods to solve the actual location problems of big dimensions i.e. hub problems of the big cities.

  4. Hub exchange operations in intermodal hub-and spoke networks : a performance comparison of rail-rail exchange facilities

    NARCIS (Netherlands)

    Bontekoning, Y.M.

    2006-01-01

    The implementation of hub-and-spoke networks in intermodal transport is suggested as one of the potential solutions for helping to increase the intermodal market share. Traditionally, trains are shunted at hubs; this is a time-consuming process. Since the early 1990s a new type of intermodal termina

  5. Computational fluid dynamics analysis of a twisted airfoil shaped two-bladed H-Darrieus rotor made from fibreglass reinforced plastic (FRP

    Directory of Open Access Journals (Sweden)

    Rajat Gupta, Sukanta Roy, Agnimitra Biswas

    2010-11-01

    Full Text Available H-Darrieus rotor is a lift type device having two to three blades designed as airfoils. The blades are attached vertically to the central shaft through support arms. The support to vertical axis helps the rotor maintain its shape. In this paper, Computational Fluid Dynamics (CFD analysis of an airfoil shaped two-bladed H-Darrieus rotor using Fluent 6.2 software was performed. Based on the CFD results, a comparative study between experimental and computational works was carried out. The H-Darrieus rotor was 20cm in height, 5cm in chord and twisted with an angle of 30° at the trailing end. The blade material of rotor was Fiberglass Reinforced Plastic (FRP. The experiments were earlier conducted in a subsonic wind tunnel for various height-to-diameter (H/D ratios. A two dimensional computational modeling was done with the help of Gambit tool using unstructured grid. Realistic boundary conditions were provided for the model to have synchronization with the experimental conditions. Two dimensional steady-state segregated solver with absolute velocity formulation and cell based grid was considered, and a standard k-epsilon viscous model with standard wall functions was chosen. A first order upwind discretization scheme was adopted for pressure velocity coupling of the flow. The inlet velocities and rotor rotational speeds were taken from the experimental results. From the computational analysis, power coefficient (Cp and torque coefficient (Ct values at ten different H/D ratios namely 0.85, 1.0, 1.10, 1.33, 1.54, 1.72, 1.80, 1.92, 2.10 and 2.20 were calculated in order to predict the performances of the twisted H-rotor. The variations of Cp and Ct with tip speed ratios were analyzed and compared with the experimental results. The standard deviations of computational Cp and Ct from experimental Cp and Ct were obtained. From the computational analysis, the highest values of Cp and Ct were obtained at H/D ratios of 1.0 and 1.54 respectively. The

  6. Flow Merging and Hub Route Optimization in Collaborative Transportation

    Directory of Open Access Journals (Sweden)

    Kerui Weng

    2014-01-01

    Full Text Available This paper studies the optimal hub routing problem of merged tasks in collaborative transportation. This problem allows all carriers’ transportation tasks to reach the destinations optionally passing through 0, 1, or 2 hubs within limited distance, while a cost discount on arcs in the hub route could be acquired after paying fixed charges. The problem arises in the application of logistics, postal services, airline transportation, and so forth. We formulate the problem as a mixed-integer programming model, and provide two heuristic approaches, respectively, based on Lagrangian relaxation and Benders decomposition. Computational experiments show that the algorithms work well.

  7. GitHub open source project recommendation system

    OpenAIRE

    Matek, Tadej; Zebec, Svit Timej

    2016-01-01

    Hosting platforms for software projects can form collaborative social networks and a prime example of this is GitHub which is arguably the most popular platform of this kind. An open source project recommendation system could be a major feature for a platform like GitHub, enabling its users to find relevant projects in a fast and simple manner. We perform network analysis on a constructed graph based on GitHub data and present a recommendation system that uses link prediction.

  8. The Opportunities and Threats of Turning Airports into Hubs

    Science.gov (United States)

    Kraus, Andreas; Koch, Benjamin

    2006-01-01

    This paper examines the opportunities and threats which arise when turning origin/destination airports into hubs. The analysis focuses on market development trends, competitive structures, especially in the light of airline network strategies and the growing rivalry between airports, and finally the potential financial impacts for the airport, including both investment efforts and the financial results from hub operations. We argue that in most cases a decision against converting a traditional origin/destination airport into a major transfer point is preferable to the transformation into a hub.

  9. A Hedonism Hub in the Human Brain

    Science.gov (United States)

    Zacharopoulos, G.; Lancaster, T. M.; Bracht, T.; Ihssen, N.; Maio, G. R.; Linden, D. E. J.

    2016-01-01

    Human values are abstract ideals that motivate behavior. The motivational nature of human values raises the possibility that they might be underpinned by brain structures that are particularly involved in motivated behavior and reward processing. We hypothesized that variation in subcortical hubs of the reward system and their main connecting pathway, the superolateral medial forebrain bundle (slMFB) is associated with individual value orientation. We conducted Pearson's correlation between the scores of 10 human values and the volumes of 14 subcortical structures and microstructural properties of the medial forebrain bundle in a sample of 87 participants, correcting for multiple comparisons (i.e.,190). We found a positive association between the value that people attach to hedonism and the volume of the left globus pallidus (GP).We then tested whether microstructural parameters (i.e., fractional anisotropy and myelin volume fraction) of the slMFB, which connects with the GP, are also associated to hedonism and found a significant, albeit in an uncorrected level, positive association between the myelin volume fraction within the left slMFB and hedonism scores. This is the first study to elucidate the relationship between the importance people attach to the human value of hedonism and structural variation in reward-related subcortical brain regions. PMID:27473322

  10. Idea Hubs as Nexus of Collective Creativity in Digital Innovation

    DEFF Research Database (Denmark)

    Ciriello, Raffaele; Richter, Alexander

    2015-01-01

    on instances of idea hubs in two multinational European software companies, where we conducted a case study over a two-year period, and collected data in form of interviews, digital documents, and participant observations. In doing so, we identify a set of social networking practices in which idea hubs serve......Digital innovation radically transforms the nature of corporate innovation practices, implying a growing need for deeper understanding its origins and outcomes. In this paper, we conceptualize the focal points of social networking in digital innovation as idea hubs. We focus our analysis...... as nexus of collective creativity and subject these to a critical dialectical examination. We discuss three influencing factors of idea hub choice, namely material infrastructure, innovation process phase, and personal characteristics. These explain why in a corporate environment, despite a variety...

  11. 14 CFR 398.2 - Number and designation of hubs.

    Science.gov (United States)

    2010-01-01

    ... origin and designation data; (iv) The distance of candidate hubs from the eligible place; and (v) The... may instead require that service from an eligible place be provided to a nearby focal point...

  12. Model of Controlling the Hubs in P2P Networks

    Directory of Open Access Journals (Sweden)

    Yuhua Liu

    2009-06-01

    Full Text Available Research into the hubs in Peer-to-Peer (P2P networks, and present a new method to avoid generating the hubs in the networks by controlling the logical topology structure of P2P networks. We firstly introduce the controlling ideas about hierarchizing the hubs. Then, we disclose and interpret the controlling model, and give out the concrete method to carry it out. Finally, we validate our controlling model via simulations and the simulation results demonstrate that our work is effective to control the hubs in P2P networks. Thus, this model can improve the network competence to defend against coordinated attacks, promote the network robustness, and ensure the network would develop continually and healthily.

  13. A Flexible Logistics Distribution Hub Model considering Cost Weighted Time

    Directory of Open Access Journals (Sweden)

    Wenxue Ran

    2017-01-01

    Full Text Available The delivery time of order has become an important fact for customers to evaluate logistics services. Due to the diverse and large quantities of orders in the background of electronic commerce, how to improve the flexibility of distribution hub and reduce the waiting time of customers becomes one of the most challenging questions for logistics companies. With this in mind, this paper proposes a new method of flexibility assessment in distribution hub by introducing cost weighted time (CWT. The advantages of supply hub operation mode in delivery flexibility are verified by the approach: the mode has pooling effects and uniform distribution characteristics; these traits can reduce overlapping delivery time to improve the flexibility in the case of two suppliers. Numerical examples show that the supply hub operation mode is more flexible than decentralized distribution operation mode in multidelivery cycles.

  14. Establishing a Global Halal Hub: In-Depth Interviews

    Directory of Open Access Journals (Sweden)

    Mahdi Borzooei

    2013-10-01

    Full Text Available The purpose of this study is to explore the requirements needed for a country to establish itself as a global Halal hub. In this regard, this exploratory research paper uses a semi-structured in-depth interview to obtain the perceptions of Halal experts about the requirements for establishing a Halal hub. The results of the study indicate that human capital, media, research and development, events, country’s capability, public and governmental support, marketing strategy, and infrastructure comprise the vital requirements. Furthermore, from the perceptions of the experts, public and governmental support, marketing strategy, and human capital are the three most important requirements. Since this paper is an exploratory study, it provides some insights of the three experts on the establishing of a Halal hub. In addition, a quantitative study is an appropriate approach to implement the findings of this study empirically and to determine the effective components to establish a Halal hub in those countries that desire it. A practical implication of this study is the opening of a new window for any country that aspires to be a Halal hub. In this matter, this paper presents the key considerations in establishing a Halal hub for Halal certification bodies, companies and marketers involved in the Halal business. Moreover, this research attempts to influence the perceptions and attitudes of people of the country on the desirability of becoming a Halal hub, followed by a discussion on the development of a national brand. When the contribution of its people is high, a country stands the best chance of achieving its goal. Finally, this study is one of the first to seek the perceptions of experts about vital requirements that a country should pay more attention to if it wishes to establish a global Halal hub.

  15. A Hub Matrix Theory and Applications to Wireless Communications

    Directory of Open Access Journals (Sweden)

    Kung HT

    2007-01-01

    Full Text Available This paper considers communications and network systems whose properties are characterized by the gaps of the leading eigenvalues of for a matrix . It is shown that a sufficient and necessary condition for a large eigen-gap is that is a "hub" matrix in the sense that it has dominant columns. Some applications of this hub theory in multiple-input and multiple-output (MIMO wireless systems are presented.

  16. Why do European companies have Innovation Hubs in Silicon Valley

    DEFF Research Database (Denmark)

    Berger, Andreas; Brem, Alexander

    2017-01-01

    Innovation hubs are gaining high attention in recent years, especially from European companies. Silicon Valley has been deemed as one of the most attractive and successful environments for establishing innovation hubs. This article highlights examples of companies from Europe that made the step t...... to California—namely, Volkswagen, Swisscom, BMW, Axel Springer, Munich Re, and Innogy SE (RWE Group). Based on these companies’ experiences, recommendations are given on how companies might approach a setup in Silicon Valley for long-term success....

  17. Concerted perturbation observed in a hub network in Alzheimer's disease.

    Directory of Open Access Journals (Sweden)

    Dapeng Liang

    Full Text Available Alzheimer's disease (AD is a progressive neurodegenerative disease involving the alteration of gene expression at the whole genome level. Genome-wide transcriptional profiling of AD has been conducted by many groups on several relevant brain regions. However, identifying the most critical dys-regulated genes has been challenging. In this work, we addressed this issue by deriving critical genes from perturbed subnetworks. Using a recent microarray dataset on six brain regions, we applied a heaviest induced subgraph algorithm with a modular scoring function to reveal the significantly perturbed subnetwork in each brain region. These perturbed subnetworks were found to be significantly overlapped with each other. Furthermore, the hub genes from these perturbed subnetworks formed a connected hub network consisting of 136 genes. Comparison between AD and several related diseases demonstrated that the hub network was robustly and specifically perturbed in AD. In addition, strong correlation between the expression level of these hub genes and indicators of AD severity suggested that this hub network can partially reflect AD progression. More importantly, this hub network reflected the adaptation of neurons to the AD-specific microenvironment through a variety of adjustments, including reduction of neuronal and synaptic activities and alteration of survival signaling. Therefore, it is potentially useful for the development of biomarkers and network medicine for AD.

  18. Identification of promising Twin Hub networks: Report of Work Package 1 of the Intermodal rail freight Twin hub Network Northwest Europe - project (final report)

    NARCIS (Netherlands)

    Kreutzberger, E.D.; Konings, J.W.; Meijer, S.; Witteveen, C.; Meijers, B.M.; Pekin, E.; Macharis, C.; Kiel, J.; Kawabata, Y.; Vos, W.

    2014-01-01

    This report is the first deliverable of the project Intermodal Rail Freight Twin Hub Network Northwest Europe. We call its subject Twin hub network and the organisational entity to carry out the actions the Twin hub project. The project is funded by INTERREG NWE (programme IVb). Its work started in

  19. Why Do Hubs Tend to Be Essential in Protein Networks?

    Directory of Open Access Journals (Sweden)

    2006-06-01

    Full Text Available The protein-protein interaction (PPI network has a small number of highly connected protein nodes (known as hubs and many poorly connected nodes. Genome-wide studies show that deletion of a hub protein is more likely to be lethal than deletion of a non-hub protein, a phenomenon known as the centrality-lethality rule. This rule is widely believed to reflect the special importance of hubs in organizing the network, which in turn suggests the biological significance of network architectures, a key notion of systems biology. Despite the popularity of this explanation, the underlying cause of the centrality-lethality rule has never been critically examined. We here propose the concept of essential PPIs, which are PPIs that are indispensable for the survival or reproduction of an organism. Our network analysis suggests that the centrality-lethality rule is unrelated to the network architecture, but is explained by the simple fact that hubs have large numbers of PPIs, therefore high probabilities of engaging in essential PPIs. We estimate that ~ 3% of PPIs are essential in the yeast, accounting for ~ 43% of essential genes. As expected, essential PPIs are evolutionarily more conserved than nonessential PPIs. Considering the role of essential PPIs in determining gene essentiality, we find the yeast PPI network functionally more robust than random networks, yet far less robust than the potential optimum. These and other findings provide new perspectives on the biological relevance of network structure and robustness.

  20. Why do hubs tend to be essential in protein networks?

    Directory of Open Access Journals (Sweden)

    Xionglei He

    2006-06-01

    Full Text Available The protein-protein interaction (PPI network has a small number of highly connected protein nodes (known as hubs and many poorly connected nodes. Genome-wide studies show that deletion of a hub protein is more likely to be lethal than deletion of a non-hub protein, a phenomenon known as the centrality-lethality rule. This rule is widely believed to reflect the special importance of hubs in organizing the network, which in turn suggests the biological significance of network architectures, a key notion of systems biology. Despite the popularity of this explanation, the underlying cause of the centrality-lethality rule has never been critically examined. We here propose the concept of essential PPIs, which are PPIs that are indispensable for the survival or reproduction of an organism. Our network analysis suggests that the centrality-lethality rule is unrelated to the network architecture, but is explained by the simple fact that hubs have large numbers of PPIs, therefore high probabilities of engaging in essential PPIs. We estimate that approximately 3% of PPIs are essential in the yeast, accounting for approximately 43% of essential genes. As expected, essential PPIs are evolutionarily more conserved than nonessential PPIs. Considering the role of essential PPIs in determining gene essentiality, we find the yeast PPI network functionally more robust than random networks, yet far less robust than the potential optimum. These and other findings provide new perspectives on the biological relevance of network structure and robustness.

  1. New approaches to the marine transport hub competitive growth

    Directory of Open Access Journals (Sweden)

    M. V. Botnaryuk

    2010-12-01

    Full Text Available The issues of marine transport hub competitive growth in the context of new economic conditions are considered in the paper. Analyzing the present tools of the transport hub competitive growth, the author emphasizes their production-logistics orientation. However, when rendering services to cargo and ship owners, members of the MTH establish official (contractual and informal relationship and exchange information on a permanent basis. The research into the nature of such a relationship brought the author to the conclusion that generation and further development of the partnership is a basis for new ways of the transport hub competitive growth. Considering the MTH as an institution, the author suggests that a general marketing information system intended for improvement of the services rendered, which will undeniably enhance competitive advantage.

  2. An environmental transfer hub for multimodal atom probe tomography.

    Science.gov (United States)

    Perea, Daniel E; Gerstl, Stephan S A; Chin, Jackson; Hirschi, Blake; Evans, James E

    2017-01-01

    Environmental control during transfer between instruments is required for samples sensitive to air or thermal exposure to prevent morphological or chemical changes prior to analysis. Atom probe tomography is a rapidly expanding technique for three-dimensional structural and chemical analysis, but commercial instruments remain limited to loading specimens under ambient conditions. In this study, we describe a multifunctional environmental transfer hub allowing controlled cryogenic or room-temperature transfer of specimens under atmospheric or vacuum pressure conditions between an atom probe and other instruments or reaction chambers. The utility of the environmental transfer hub is demonstrated through the acquisition of previously unavailable mass spectral analysis of an intact organic molecule made possible via controlled cryogenic transfer into the atom probe using the hub. The ability to prepare and transfer specimens in precise environments promises a means to access new science across many disciplines from untainted samples and allow downstream time-resolved in situ atom probe studies.

  3. Microfluidic hubs, systems, and methods for interface fluidic modules

    Energy Technology Data Exchange (ETDEWEB)

    Bartsch, Michael S; Claudnic, Mark R; Kim, Hanyoup; Patel, Kamlesh D; Renzi, Ronald F; Van De Vreugde, James L

    2015-01-27

    Embodiments of microfluidic hubs and systems are described that may be used to connect fluidic modules. A space between surfaces may be set by fixtures described herein. In some examples a fixture may set substrate-to-substrate spacing based on a distance between registration surfaces on which the respective substrates rest. Fluidic interfaces are described, including examples where fluid conduits (e.g. capillaries) extend into the fixture to the space between surfaces. Droplets of fluid may be introduced to and/or removed from microfluidic hubs described herein, and fluid actuators may be used to move droplets within the space between surfaces. Continuous flow modules may be integrated with the hubs in some examples.

  4. Mapping multiplex hubs in human functional brain networks

    Directory of Open Access Journals (Sweden)

    Alex Arenas

    2016-07-01

    Full Text Available Typical brain networks consist of many peripheral regions and a few highly centralones, i.e. hubs, playing key functional roles in cerebral inter-regional interactions. Studieshave shown that networks, obtained from the analysis of specific frequency components ofbrain activity, present peculiar architectures with unique profiles of region centrality. However,the identification of hubs in networks built from different frequency bands simultaneouslyis still a challenging problem, remaining largely unexplored. Here we identify eachfrequency component with one layer of a multiplex network and face this challenge by exploitingthe recent advances in the analysis of multiplex topologies. First, we show that eachfrequency band carries unique topological information, fundamental to accurately modelbrain functional networks. We then demonstrate that hubs in the multiplex network, in generaldifferent from those ones obtained after discarding or aggregating the measured signalsas usual, provide a more accurate map of brain’s most important functional regions, allowingto distinguish between healthy and schizophrenic populations better than conventionalnetwork approaches.

  5. A new method for improved hub height mean wind speed estimates using short-term hub height data

    Energy Technology Data Exchange (ETDEWEB)

    Lackner, Matthew A.; Rogers, Anthony L.; Manwell, James F.; McGowan, Jon G. [Wind Energy Center, Department of Mechanical and Industrial Engineering, University of Massachusetts Amherst, 160 Governors Dr., Amherst, MA 01003 (United States)

    2010-10-15

    The estimation of the wind resource at the hub height of a wind turbine is one of the primary goals of site assessment. Because the measurement heights of meteorological towers (met towers) are typically significantly lower than turbine hub heights, a shear model is generally needed to extrapolate the measured wind resource at the lower measurement height to the hub height of the turbine. This paper presents methods for improving the estimate of the hub height wind resource from met tower data through the use of ground-based remote sensing devices. The methods leverage the two major advantages of these devices: their portability and their ability to measure at the wind turbine hub height. Specifically, the methods rely on augmenting the one year of met tower measurements with short-term measurements from a ground-based remote sensing device. The results indicate that the methods presented are capable of producing substantial improvements in the accuracy and uncertainty of shear extrapolation predictions. The results suggest that the typical site assessment process can be reevaluated, and alternative strategies that utilize ground-based remote sensing devices can be incorporated to significantly improve the process. (author)

  6. Robust Energy Hub Management Using Information Gap Decision Theory

    DEFF Research Database (Denmark)

    Javadi, Mohammad Sadegh; Anvari-Moghaddam, Amjad; Guerrero, Josep M.

    2017-01-01

    tools in order to deal with uncertainties and to provide reliable operating conditions. On a broader scale, an energy hub includes diverse energy sources for supplying both electrical load and heating/cooling demands with stochastic behaviors. Therefore, this paper utilizes the Information Decision Gap...... Theory (IGDT) to tackle this uncertainty as an efficient robust optimization tool with low complexity to ensure the optimal operation of the system according to the priorities of the decision maker entity. The proposed optimization framework is also implemented on a benchmark energy hub which includes...

  7. Variable volume combustor with center hub fuel staging

    Energy Technology Data Exchange (ETDEWEB)

    Ostebee, Heath Michael; McConnaughhay, Johnie Franklin; Stewart, Jason Thurman; Keener, Christopher Paul

    2016-08-23

    The present application and the resultant patent provide a combustor for use with a gas turbine engine. The combustor may include a number of micro-mixer fuel nozzles and a fuel injection system for providing a flow of fuel to the micro-mixer fuel nozzles. The fuel injection system may include a center hub for providing the flow of fuel therethrough. The center hub may include a first supply circuit for a first micro-mixer fuel nozzle and a second supply circuit for a second micro-mixer fuel nozzle.

  8. Bus coordination holding control for transit hubs under APTS

    Institute of Scientific and Technical Information of China (English)

    TENG Jing; ZHAO Ming

    2009-01-01

    To increase the passenger transferring efficiency, the bus coordination holding control for transit hubs,hich is as an important dynamic dispatching method for improving the service level of transit hubs, was studied in the framework of bus coordination dispatching mode. Firstly, the bus coordination holding control flow was studied based on Advanced Public Transportation Systems (APTS) environment. Then a control model was presented to optimize the bus vehicle holding time, and a genetic algorithm was designed as the solving method. In the end, an example was given to illustrate the effectiveness of the control strategy and the algorithm.

  9. Portable Desktop Apps with GitHub Electron

    CERN Document Server

    CERN. Geneva

    2016-01-01

    Wouldn't it be nice if you could develop applications that work everywhere, regardless of Operating System or Platform? Even better, what if you could employ the same front-end technologies you use for your web/mobile apps? Meet GitHub Electron.

  10. The evolution of the MasAgro hubs

    NARCIS (Netherlands)

    Camacho-Villa, Tania Carolina; Almekinders, Conny; Hellin, Jon; Martinez-Cruz, Tania Eulalia; Rendon-Medel, Roberto; Guevara-Hernández, Francisco; Beuchelt, Tina D.; Govaerts, Bram

    2016-01-01

    Purpose: Little is known about effective ways to operationalize agricultural innovation processes. We use the MasAgro program in Mexico (which aims to increase maize and wheat productivity, profitability and sustainability), and the experiences of middle level ‘hub managers’, to understand how innov

  11. Native Avatars, Online Hubs, and Urban Indian Literature

    Science.gov (United States)

    Estrada, Gabriel S.

    2011-01-01

    Teaching American Indian literature with online resources can help diverse urban Indian and multicultural students connect with American Indian cultures, histories, and Nations. This online-enriched pedagogy adopts Susan Lobo's sense of the city as an "urban hub," or activist community center, an urban area linked to reservations in which Native…

  12. Fatigue Analysis of Casted Hubs in Wind Turbines

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Nielsen, Søren R.K.; Sørensen, Steffen

    2002-01-01

    The hub of a wind turbine rotor is excited by time-varying forces and moments from the blades caused by extemal dynamic loads such as wind loading and aeroelastic effects. The paper describes how reliability-based fatigue analysis can be made based on SN-curves and how reliability-based inspectio...

  13. Functional Connectivity Hubs and Networks in the Awake Marmoset Brain

    Directory of Open Access Journals (Sweden)

    Annabelle Marie Belcher

    2016-03-01

    Full Text Available In combination with advances in analytical methods, resting-state fMRI is allowing unprecedented access to achieve a better understanding of the network organization of the brain. Increasing evidence suggests that this architecture may incorporate highly functionally connected nodes, or hubs, and we have recently proposed local functional connectivity density (lFCD mapping to identify highly-connected nodes in the human brain. Here we imaged awake nonhuman primates to test whether, like the human brain, the marmoset brain contains functional connectivity hubs. Ten adult common marmosets (Callithrix jacchus were acclimated to mild, comfortable restraint using individualized helmets. Following restraint training, resting BOLD data were acquired during eight consecutive 10 min scans for each subject. lFCD revealed prominent cortical and subcortical hubs of connectivity across the marmoset brain; specifically, in primary and secondary visual cortices (V1/V2, higher-order visual association areas (A19M/V6[DM], posterior parietal and posterior cingulate areas (PGM and A23b/A31, thalamus, dorsal and ventral striatal areas (caudate, putamen, lateral septal nucleus, and anterior cingulate cortex (A24a. lFCD hubs were highly connected to widespread areas of the brain, and further revealed significant network-network interactions. These data provide a baseline platform for future investigations in a nonhuman primate model of the brain’s network topology.

  14. The evolution of the MasAgro hubs

    NARCIS (Netherlands)

    Camacho-Villa, Tania Carolina; Almekinders, Conny; Hellin, Jon; Martinez-Cruz, Tania Eulalia; Rendon-Medel, Roberto; Guevara-Hernández, Francisco; Beuchelt, Tina D.; Govaerts, Bram

    2016-01-01

    Purpose: Little is known about effective ways to operationalize agricultural innovation processes. We use the MasAgro program in Mexico (which aims to increase maize and wheat productivity, profitability and sustainability), and the experiences of middle level ‘hub managers’, to understand how

  15. DAVINC3I: moving towards responsive hub network designs

    NARCIS (Netherlands)

    Ossevoort, R.; Keizer, de M.; Vorst, van der J.G.A.J.; Wenink, E.

    2013-01-01

    The Dutch floricultural sector is generally appreciated for its world leadership; the Netherlands is the flower trading hub for the European market. There are two trends affecting this position. First, virtualisation makes trade flows relatively footloose and flexible. Moreover, it enables the use o

  16. Discovering Authorities and Hubs in Different Topological Web Graph Structures.

    Science.gov (United States)

    Meghabghab, George

    2002-01-01

    Discussion of citation analysis on the Web considers Web hyperlinks as a source to analyze citations. Topics include basic graph theory applied to Web pages, including matrices, linear algebra, and Web topology; and hubs and authorities, including a search technique called HITS (Hyperlink Induced Topic Search). (Author/LRW)

  17. DAVINC3I: moving towards responsive hub network designs

    NARCIS (Netherlands)

    Ossevoort, R.; Keizer, de M.; Vorst, van der J.G.A.J.; Wenink, E.

    2013-01-01

    The Dutch floricultural sector is generally appreciated for its world leadership; the Netherlands is the flower trading hub for the European market. There are two trends affecting this position. First, virtualisation makes trade flows relatively footloose and flexible. Moreover, it enables the use o

  18. Interaction of railway and marine transport (Murmansk Transport Hub

    Directory of Open Access Journals (Sweden)

    Sokolov A.A.

    2015-03-01

    Full Text Available The classification of problems of interaction between water (marine and railway transport on the example of the Murmansk Transport Hub has been presented; some prospects for the development of technology for interaction with the logistics of transportation of general cargo in the Murmansk Commercial Seaport, Murmansk Marine Fishing Port, and oil terminals of the Kola Bay have been shown

  19. The Urban Food Hubs Solution: Building Capacity in Urban Communities

    Science.gov (United States)

    O'Hara, Sabine

    2017-01-01

    Access to affordable fresh food is an ongoing challenge for underserved urban neighborhoods across the United States. Several are designated food deserts with no access to a full-service grocery store within a one-mile radius. The Urban Food Hubs of the College of Agriculture, Urban Sustainability, and Environmental Sciences (CAUSES) of the…

  20. Multiple Hub Network Choice in the Liberalized European Market

    Science.gov (United States)

    Berechman, Joseph; deWit, Jaap

    1997-01-01

    A key question that so far has received relatively little attention in the germane literature is that of the changes at various airports as a result of the EU liberalization policies. That is, presently, most major European airports still benefit from the so-called home-carrier phenomenon where the country's publicly or semi-publicly owned carrier uses the country's main airport as its gateway hub and, consequently, the home-carrier is also the principal user of this airport (in terms of proportion of total aircraft movements, number of passengers transported, connections, slots ownership, etc.). The country's main airport has substantially benefited from these monopoly conditions of airline captivity, strongly determined by the bilateral system of international air transport regulation. Therefore, European major airports were used to operate in essentially different markets, compared to the increasingly competitive markets of their home based carriers. This partly explains relative stability of transport volumes and financial results of European major airports compared to the relatively volatile financial results of most European national airlines. However, the liberalization of European aviation is likely to change this situation. Market access is open now to all community carriers, i.e. carriers with majority ownership and effective control in the hands of EU citizens. Ticket prices are free, governments can only intervene in case of dumping or excessive pricing. A community airline can choose its seat in any of the 15 member states. Licensing procedures are harmonized between member states. In the last few months community carriers have had unrestricted route access within the EU. Most probably this development will be extended to countries inside and outside Europe. Last year the European Commission got the mandate to start negotiations with 10 other European countries. In the meantime the EC has also started negotiations with the USA on so-called soft rights

  1. Revisiting date and party hubs: novel approaches to role assignment in protein interaction networks.

    Directory of Open Access Journals (Sweden)

    Sumeet Agarwal

    2010-06-01

    Full Text Available The idea of "date" and "party" hubs has been influential in the study of protein-protein interaction networks. Date hubs display low co-expression with their partners, whilst party hubs have high co-expression. It was proposed that party hubs are local coordinators whereas date hubs are global connectors. Here, we show that the reported importance of date hubs to network connectivity can in fact be attributed to a tiny subset of them. Crucially, these few, extremely central, hubs do not display particularly low expression correlation, undermining the idea of a link between this quantity and hub function. The date/party distinction was originally motivated by an approximately bimodal distribution of hub co-expression; we show that this feature is not always robust to methodological changes. Additionally, topological properties of hubs do not in general correlate with co-expression. However, we find significant correlations between interaction centrality and the functional similarity of the interacting proteins. We suggest that thinking in terms of a date/party dichotomy for hubs in protein interaction networks is not meaningful, and it might be more useful to conceive of roles for protein-protein interactions rather than for individual proteins.

  2. Location of an intermediate hub for port activities

    Science.gov (United States)

    Burciu, Ş.; Ştefănică, C.; Roşca, E.; Dragu, V.; Ruscă, F.

    2015-11-01

    An intermediate hub might increase the accessibility level of ports but also hinterland and so it can be considered more than a facility with a transhipment role. These hubs might lead to the development of other transport services and enhance their role in gathering and covering economic centres within hinterlands and also getting the part of logistic facility for the ports, with effects on port utilization and its connectivity to global economy. A new location for a hub terminal leads to reduced transport distances within hinterland, with decreased transport costs and external effects, so with gains in people's life quality. Because the production and distribution systems are relatively fixed on short and medium term and the location decisions are strategic and on long term, the logistic chains activities location models have to consider the uncertainties regarding the possible future situations. In most models, production costs are considered equal, the location problem reducing itself to a problem that aims to minimize the total transport costs, meaning the transport problem. The main objective of the paper is to locate a hub terminal that links the producers of cereals that are going to be exported by naval transportation with the Romanian fluvial-maritime ports (Galaţi, Brăila). GIS environment can be used to integrate and analyse a great amount of data and has the ability of using functions as location - allocation models necessary both to private and public sector, being able to determine the optimal location for services like factories, warehouses, logistic platforms and other public services.

  3. An environmental transfer hub for multimodal atom probe tomography

    Energy Technology Data Exchange (ETDEWEB)

    Perea, Daniel E.; Gerstl, Stephan S. A.; Chin, Jackson; Hirschi, Blake; Evans, James. E.

    2017-05-02

    Environmental control during transfer between instruments is required for specimens sensitive to air or thermal exposure to prevent morphological or chemical changes. Atom Probe Tomography is an expanding technique but commercial instruments remain limited to loading under ambient conditions. Here we describe a multifunctional environmental transfer hub allowing controlled cryogenic, atmospheric and vacuum transfer between an Atom Probe and other instruments containing separate chambers to allow downstream time-resolved in-situ studies.

  4. The new forging process of a wheel hub drop forging

    Directory of Open Access Journals (Sweden)

    A. Gontarz

    2006-08-01

    Full Text Available Purpose: The main purpose of the research was working out a new flashless forming process of wheel hubforging in three-slide forging press (TSFP. It was assumed that the new process would be more effective thanthe forging processes applied in typical forging machines.Design/methodology/approach: The designing of the new process was based on the simulation by finiteelement method with the assumption of 3D state of strain. Calculations were made mainly for the analysis of thematerial flow kinematics and the process loads parameters. Experimental research were also made determiningthe dependency of clamping load in the function of forming load. On the basis of the analysis, the formingprocess of a wheel hub drop forging on the TSFP was worked out.Findings: The results of research confirmed the possibility of flashless forming process of wheel hub forgingin TSFP with axial cavities. The main parameters limiting the forming processes of wheel hub forgings are:permissible upsetting ratio and reciprocal relation of forming and clamping forces.Research limitations/implications: The further research within the range of determining force parameters fordifferent types of material and schemata of forming in TSFP were considered as purposeful. The works dealingwith analysis of forming processes of different types of products in order to classify drop forgings possible toform in this press will be examined.Practical implications: The comparison of the new forming process with the forging process on hammershowed majority of advantages which include: decrease of time and energy, decrease of drop forging weight andmachining, decrease of material consumption.Originality/value: The new process of wheel hub forging forming with axial cavities was worked out. Theparameters important during designing of forming processes in TSFP were provided. The relations betweenforces of forming tools were also determined.

  5. The home hemodialysis hub: physical infrastructure and integrated governance structure.

    Science.gov (United States)

    Marshall, Mark R; Young, Bessie A; Fox, Sally J; Cleland, Calli J; Walker, Robert J; Masakane, Ikuto; Herold, Aaron M

    2015-04-01

    An effective home hemodialysis program critically depends on adequate hub facilities and support functions and on transparent and accountable organizational processes. The likelihood of optimal service delivery and patient care will be enhanced by fit-for-purpose facilities and implementation of a well-considered governance structure. In this article, we describe the required accommodation and infrastructure for a home hemodialysis program and a generic organizational structure that will support both patient-facing clinical activities and business processes.

  6. Robust design of a polygonal shaft-hub coupling

    Directory of Open Access Journals (Sweden)

    R. Citarella

    2015-10-01

    Full Text Available In this work, the Taguchi method is applied for the optimal choice of design parameter values for a polygonal shaft-hub coupling. The objective is to maximize a performance function, minimizing, at the same time, its sensitivity to noises factors (robust design. The Design of Experiments (DoE is adopted to set up a plan of numerical experiments, whose different configurations are simulated using the Boundary Element Method (BEM

  7. Performance evaluation of interconnected logistics networks confronted to hub disruptions

    OpenAIRE

    2016-01-01

    International audience; This paper investigates performance of interconnected logistics networks confronted to disruptions at hub level. With traditional supply chain network design, companies define and optimize their own logistics networks, resulting in current logistics systems being a set of independent heterogeneous logistics networks. The concept of PI aims to integrate independent logistics networks into a global, open, interconnected system. Prior research has shown that the new organ...

  8. Looking east, looking west: Penang as a knowledge hub

    OpenAIRE

    Gerke, Solvay; Evers, Hans-Dieter

    2012-01-01

    Penang has always been a focal point, absorbing knowledge (and popular culture) from civilizations to the East and West. In modern Penang the pattern of cultural contacts has changed over time. Research institutes and universities in Penang cooperate with foreign partners to produce research papers and reports. Based on an analysis of joint research output, the changing international position of Penang as an emerging research hub will be analysed. The paper will show that international cooper...

  9. A Hub Matrix Theory and Applications to Wireless Communications

    Directory of Open Access Journals (Sweden)

    H. T. Kung

    2007-01-01

    Full Text Available This paper considers communications and network systems whose properties are characterized by the gaps of the leading eigenvalues of AHA for a matrix A. It is shown that a sufficient and necessary condition for a large eigen-gap is that A is a “hub” matrix in the sense that it has dominant columns. Some applications of this hub theory in multiple-input and multiple-output (MIMO wireless systems are presented.

  10. Logistics service sharing in supply hub in industrial park (SHIP)

    OpenAIRE

    Qiu, Xuan; 邱璇

    2013-01-01

    Industrial parks have played an indispensible role in boosting economic and industrial development. However, further development has been impeded by the shortage of land resources and by duplicate investments on common physical assets and services. This thesis proposes the concept of Supply Hub in Industrial Park (SHIP) as a public provider of warehousing and transportation services shared by manufacturing enterprises located within an industrial park. This research investigates four typic...

  11. Idea Exchange Music Hub Hits the Right Note in Community

    Directory of Open Access Journals (Sweden)

    Greg Bester

    2014-06-01

    Full Text Available The Cambridge Libraries and Galleries has made many changes over the last two years, rebranding as Idea Exchange and adding 3D printers, creative spaces and many on-site events. This article focuses on one of the organization’s newest innovations, the addition of a Music Hub, and the challenges of creating a space where members can learn and collaborate musically without disturbing those around them.

  12. Research dedusting efficiency of the inertial hub with adjustable parameters

    Directory of Open Access Journals (Sweden)

    Sharapov Rashid

    2016-01-01

    Full Text Available Production of construction materials every year production increases, thus increasing emissions pollutants into the atmosphere subjected to cleaning. At the enterprises of building materials production equipment becoming outdated both morally and physically exhausted their useful life. Technological design standards in the operation of purification equipment has undergone a number of changes. There are a large number of works devoted to the theory of cyclone separation. They examined calculation method and to determine the minimum size of particles is separated completely from the air stream in a cyclone. In theory, the high efficiency cyclones are relatively small separation of particles from the air stream. The experiments show that certain fractions of full capture occurs from the cyclones and out relatively large particles. Designed dust device hubs. They capture dust particles with low specific density and smaller than 5–10 microns. Rational use of hubs is achieved in the aspiration systems high performance. They are placed in front of or between the filter and the cyclone filter. Hub much reduces the amount of dust-laden air directed onto a thin cleaning. This reduces energy consumption for manufacturing as a whole, as well as, due to a possible decrease in performance fine filters, reducing their initial cost, metal consumption, maintenance costs and reduce the area occupied by them.

  13. Matrix logistics indicators assessment of distributed transport hub

    Directory of Open Access Journals (Sweden)

    Igor Arefyev

    2014-06-01

    Full Text Available Background: The paper is devoted to the distributed transport hub substantiation and assessment. The paper  was an example of the technique and form an array of logistical factors as variables that determine this condition. Experience in organizing multimodal transport showed that the "bottleneck" of transport logistics are items of cargo handling ports, terminals, freight stations and warehouses. At the core of the solution of these problems is the problem of estimating the variables determine the Multi-purpose Hubs. The aim is to develop a method of forming the system of logistical multiplying factors determine the role of each of the types in the technologiacal process of distributed Multi-purpose Hubs. Methods: The assessment model for the formation of Distributed Transport Units  can be based on formal methods to predict the behavior of complex systems engineering complexes. Then one of the approaches to the solution of the problem may be the matrix method of technological factors. Results and conclusions: The proposed methodology of the selection and validation of logistic coefficients has the practical importance in the models development for assessing the condition and behavior of Distributed Transport.

  14. The coffee genome hub: a resource for coffee genomes.

    Science.gov (United States)

    Dereeper, Alexis; Bocs, Stéphanie; Rouard, Mathieu; Guignon, Valentin; Ravel, Sébastien; Tranchant-Dubreuil, Christine; Poncet, Valérie; Garsmeur, Olivier; Lashermes, Philippe; Droc, Gaëtan

    2015-01-01

    The whole genome sequence of Coffea canephora, the perennial diploid species known as Robusta, has been recently released. In the context of the C. canephora genome sequencing project and to support post-genomics efforts, we developed the Coffee Genome Hub (http://coffee-genome.org/), an integrative genome information system that allows centralized access to genomics and genetics data and analysis tools to facilitate translational and applied research in coffee. We provide the complete genome sequence of C. canephora along with gene structure, gene product information, metabolism, gene families, transcriptomics, syntenic blocks, genetic markers and genetic maps. The hub relies on generic software (e.g. GMOD tools) for easy querying, visualizing and downloading research data. It includes a Genome Browser enhanced by a Community Annotation System, enabling the improvement of automatic gene annotation through an annotation editor. In addition, the hub aims at developing interoperability among other existing South Green tools managing coffee data (phylogenomics resources, SNPs) and/or supporting data analyses with the Galaxy workflow manager. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  15. Spider orientation and hub position in orb webs

    Science.gov (United States)

    Zschokke, Samuel; Nakata, Kensuke

    2010-01-01

    Orb-web building spiders (Araneae: Araneoidea, Uloboridae) can be considered as territorial central place foragers. In territorial central place foragers, the optimal foraging arena is circular, with the forager sitting in its centre. In orb webs, the spider’s orientation (head up or head down) whilst waiting for prey on the hub of its web and the downwards-upwards asymmetry of its running speeds are the probable causes for the observed deviation of the hub from the web’s centre. Here, we present an analytical model and a more refined simulation model to analyse the relationships amongst the spider’s running speeds, its orientation whilst waiting for prey and the vertical asymmetry of orb webs. The results of our models suggest that (a) waiting for prey head down is generally favourable because it allows the spider to reach the prey in its web on average quicker than spiders waiting head up, (b) the downwards-upwards running speed asymmetry, together with the head-down orientation of most spiders, are likely causes for the observed vertical asymmetry of orb webs, (c) waiting head up can be advantageous for spiders whose downwards-upwards running speed asymmetry is small and who experience high prey tumbling rates and (d) spiders waiting head up should place their hub lower than similar spiders waiting head down.

  16. Mapping Multiplex Hubs in Human Functional Brain Networks

    Science.gov (United States)

    De Domenico, Manlio; Sasai, Shuntaro; Arenas, Alex

    2016-01-01

    Typical brain networks consist of many peripheral regions and a few highly central ones, i.e., hubs, playing key functional roles in cerebral inter-regional interactions. Studies have shown that networks, obtained from the analysis of specific frequency components of brain activity, present peculiar architectures with unique profiles of region centrality. However, the identification of hubs in networks built from different frequency bands simultaneously is still a challenging problem, remaining largely unexplored. Here we identify each frequency component with one layer of a multiplex network and face this challenge by exploiting the recent advances in the analysis of multiplex topologies. First, we show that each frequency band carries unique topological information, fundamental to accurately model brain functional networks. We then demonstrate that hubs in the multiplex network, in general different from those ones obtained after discarding or aggregating the measured signals as usual, provide a more accurate map of brain's most important functional regions, allowing to distinguish between healthy and schizophrenic populations better than conventional network approaches. PMID:27471443

  17. Virtual Hubs for facilitating access to Open Data

    Science.gov (United States)

    Mazzetti, Paolo; Latre, Miguel Á.; Ernst, Julia; Brumana, Raffaella; Brauman, Stefan; Nativi, Stefano

    2015-04-01

    In October 2014 the ENERGIC-OD (European NEtwork for Redistributing Geospatial Information to user Communities - Open Data) project, funded by the European Union under the Competitiveness and Innovation framework Programme (CIP), has started. In response to the EU call, the general objective of the project is to "facilitate the use of open (freely available) geographic data from different sources for the creation of innovative applications and services through the creation of Virtual Hubs". In ENERGIC-OD, Virtual Hubs are conceived as information systems supporting the full life cycle of Open Data: publishing, discovery and access. They facilitate the use of Open Data by lowering and possibly removing the main barriers which hampers geo-information (GI) usage by end-users and application developers. Data and data services heterogeneity is recognized as one of the major barriers to Open Data (re-)use. It imposes end-users and developers to spend a lot of effort in accessing different infrastructures and harmonizing datasets. Such heterogeneity cannot be completely removed through the adoption of standard specifications for service interfaces, metadata and data models, since different infrastructures adopt different standards to answer to specific challenges and to address specific use-cases. Thus, beyond a certain extent, heterogeneity is irreducible especially in interdisciplinary contexts. ENERGIC-OD Virtual Hubs address heterogeneity adopting a mediation and brokering approach: specific components (brokers) are dedicated to harmonize service interfaces, metadata and data models, enabling seamless discovery and access to heterogeneous infrastructures and datasets. As an innovation project, ENERGIC-OD will integrate several existing technologies to implement Virtual Hubs as single points of access to geospatial datasets provided by new or existing platforms and infrastructures, including INSPIRE-compliant systems and Copernicus services. ENERGIC OD will deploy a

  18. Contextual Hub Analysis Tool (CHAT: A Cytoscape app for identifying contextually relevant hubs in biological networks [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Tanja Muetze

    2016-08-01

    Full Text Available Highly connected nodes (hubs in biological networks are topologically important to the structure of the network and have also been shown to be preferentially associated with a range of phenotypes of interest. The relative importance of a hub node, however, can change depending on the biological context. Here, we report a Cytoscape app, the Contextual Hub Analysis Tool (CHAT, which enables users to easily construct and visualize a network of interactions from a gene or protein list of interest, integrate contextual information, such as gene expression or mass spectrometry data, and identify hub nodes that are more highly connected to contextual nodes (e.g. genes or proteins that are differentially expressed than expected by chance. In a case study, we use CHAT to construct a network of genes that are differentially expressed in Dengue fever, a viral infection. CHAT was used to identify and compare contextual and degree-based hubs in this network. The top 20 degree-based hubs were enriched in pathways related to the cell cycle and cancer, which is likely due to the fact that proteins involved in these processes tend to be highly connected in general. In comparison, the top 20 contextual hubs were enriched in pathways commonly observed in a viral infection including pathways related to the immune response to viral infection. This analysis shows that such contextual hubs are considerably more biologically relevant than degree-based hubs and that analyses which rely on the identification of hubs solely based on their connectivity may be biased towards nodes that are highly connected in general rather than in the specific context of interest.   Availability: CHAT is available for Cytoscape 3.0+ and can be installed via the Cytoscape App Store (http://apps.cytoscape.org/apps/chat.

  19. An Endosymbiotic Evolutionary Algorithm for the Hub Location-Routing Problem

    Directory of Open Access Journals (Sweden)

    Ji Ung Sun

    2015-01-01

    Full Text Available We consider a capacitated hub location-routing problem (HLRP which combines the hub location problem and multihub vehicle routing decisions. The HLRP not only determines the locations of the capacitated p-hubs within a set of potential hubs but also deals with the routes of the vehicles to meet the demands of customers. This problem is formulated as a 0-1 mixed integer programming model with the objective of the minimum total cost including routing cost, fixed hub cost, and fixed vehicle cost. As the HLRP has impractically demanding for the large sized problems, we develop a solution method based on the endosymbiotic evolutionary algorithm (EEA which solves hub location and vehicle routing problem simultaneously. The performance of the proposed algorithm is examined through a comparative study. The experimental results show that the proposed EEA can be a viable solution method for the supply chain network planning.

  20. The catheter hub disinfection cap as esophageal foreign body.

    Science.gov (United States)

    Tawfik, Kareem O; Myer, Charles M; Shikary, Tasneem; Goldschneider, Kenneth R

    2015-12-01

    Disinfection caps are increasingly being used to prevent catheter-associated bloodstream infections. These devices, designed for continuous passive disinfection of catheter hubs, are typically small and often brightly colored. As such, they have the potential to become pediatric airway and esophageal foreign bodies. We report two patients who developed esophageal foreign body following ingestion of disinfection caps. Given the increasing use of these devices, it is imperative that health care providers be aware of this potential iatrogenic problem. We propose that the use of disinfection caps may not be appropriate in pediatric patients with risk factors for foreign body ingestion.

  1. Wake center position tracking using downstream wind turbine hub loads

    Science.gov (United States)

    Cacciola, S.; Bertelè, M.; Schreiber, J.; Bottasso, C. L.

    2016-09-01

    Having an improved awareness of the flow within a wind farm is useful for power harvesting maximization, load minimization and design of wind farm layout. Local flow information at each wind turbine location can be obtained by using the response of the wind turbines, which are consequently used as distributed sensors. This paper proposes the use of hub loads to track the position of wakes within a wind farm. Simulation experiments conducted within a high-fidelity aeroservoelastic environment demonstrate the performance of the new method.

  2. Collective versus hub activation of epidemic phases on networks

    CERN Document Server

    Ferreira, Silvio C; Pastor-Satorras, Romualdo

    2015-01-01

    We consider a general criterion to discern the nature of the threshold in epidemic models on scale-free (SF) networks. Comparing the epidemic lifespan of the nodes with largest degrees with the infection time between them, we propose a general dual scenario, in which the epidemic transition is either ruled by a hub activation process, leading to a null threshold in the thermodynamic limit, or given by a collective activation process, corresponding to a standard phase transition with a finite threshold. We validate the proposed criterion applying it different to epidemic models, with waning immunity or heterogeneous infection rates.

  3. The hubs of the human connectome are generally implicated in the anatomy of brain disorders.

    Science.gov (United States)

    Crossley, Nicolas A; Mechelli, Andrea; Scott, Jessica; Carletti, Francesco; Fox, Peter T; McGuire, Philip; Bullmore, Edward T

    2014-08-01

    Brain networks or 'connectomes' include a minority of highly connected hub nodes that are functionally valuable, because their topological centrality supports integrative processing and adaptive behaviours. Recent studies also suggest that hubs have higher metabolic demands and longer-distance connections than other brain regions, and therefore could be considered biologically costly. Assuming that hubs thus normally combine both high topological value and high biological cost, we predicted that pathological brain lesions would be concentrated in hub regions. To test this general hypothesis, we first identified the hubs of brain anatomical networks estimated from diffusion tensor imaging data on healthy volunteers (n = 56), and showed that computational attacks targeted on hubs disproportionally degraded the efficiency of brain networks compared to random attacks. We then prepared grey matter lesion maps, based on meta-analyses of published magnetic resonance imaging data on more than 20 000 subjects and 26 different brain disorders. Magnetic resonance imaging lesions that were common across all brain disorders were more likely to be located in hubs of the normal brain connectome (P brain disorders had lesions that were significantly more likely to be located in hubs (P human brain networks are more likely to be anatomically abnormal than non-hubs in many (if not all) brain disorders. © The Author (2014). Published by Oxford University Press on behalf of the Guarantors of Brain.

  4. Design of targeted libraries against the human Chk1 kinase using PGVL Hub.

    Science.gov (United States)

    Peng, Zhengwei; Hu, Qiyue

    2011-01-01

    PGVL Hub is a Pfizer internal desktop tool for chemical library and singleton design. In this chapter, we give a short introduction to PGVL Hub, the core workflow it supports, and the rich design capabilities it provides. By re-creating two legacy targeted libraries against the human checkpoint kinase 1 (Chk1) as a showcase, we illustrate how PGVL Hub could be used to help library designers carry out the steps in library design and realize design objectives such as SAR expansion and improvement in both kinase selectivity and compound aqueous solubility. Finally we share several tips about library design and usage of PGVL Hub.

  5. PASSENGER SERVICE QUALITY PARAMETERS ASSESSMENT AT TRANSPORT INTERCHANGE HUBS

    Directory of Open Access Journals (Sweden)

    Kozlov Pavel Igorevich

    2017-05-01

    Full Text Available The article discusses a quality assessment method for transport decisions made in transport interchange hubs. Analysis of domestic regulatory documentation and international experience on this subject is performed. It is stated that the domestic regulatory documentation lacks such method of assessment. Special attention is paid to study of pedestrian flows in interchange complexes of intermodal transport interchange hubs. The aim of the study is development of the Level of Service comprehensive assessment criterion by analogy with the international practice. The authors propose to use the queueing theory with elements of the theory of graphs, techniques and regularities that underlie the Level of Service (service factor applied in planning and location of TIH in the USA as well as data from field surveys carried out by the pedestrian flows video detection method. During the field surveys it is planned to perform analysis of external and internal factors influencing the formation and composition of a pedestrian flow, to determine quantitative values of the main parameters of pedestrian flow (density, speed, intensity and regularities of their variation depending on the design features of pedestrian traffic environment. Determination of passenger service quality factors in TIH will help to develop an integral criterion based on the Level of Service, taking into account the specifics of TIH functioning in Russia as well as a methodology that allows a reasonable choice of combinations of structural elements and planning parameters of pedestrian traffic objects which will let to reduce construction costs and operating costs for location of interchange complexes.

  6. Disinfection of Needleless Connector Hubs: Clinical Evidence Systematic Review

    Science.gov (United States)

    Moureau, Nancy L.

    2015-01-01

    Background. Needleless connectors (NC) are used on virtually all intravascular devices, providing an easy access point for infusion connection. Colonization of NC is considered the cause of 50% of postinsertion catheter-related infections. Breaks in aseptic technique, from failure to disinfect, result in contamination and subsequent biofilm formation within NC and catheters increasing the potential for infection of central and peripheral catheters. Methods. This systematic review evaluated 140 studies and 34 abstracts on NC disinfection practices, the impact of hub contamination on infection, and measures of education and compliance. Results. The greatest risk for contamination of the catheter after insertion is the NC with 33–45% contaminated, and compliance with disinfection as low as 10%. The optimal technique or disinfection time has not been identified, although scrubbing with 70% alcohol for 5–60 seconds is recommended. Studies have reported statistically significant results in infection reduction when passive alcohol disinfection caps are used (48–86% reduction). Clinical Implications. It is critical for healthcare facilities and clinicians to take responsibility for compliance with basic principles of asepsis compliance, to involve frontline staff in strategies, to facilitate education that promotes understanding of the consequences of failure, and to comply with the standard of care for hub disinfection. PMID:26075093

  7. Disinfection of Needleless Connector Hubs: Clinical Evidence Systematic Review

    Directory of Open Access Journals (Sweden)

    Nancy L. Moureau

    2015-01-01

    Full Text Available Background. Needleless connectors (NC are used on virtually all intravascular devices, providing an easy access point for infusion connection. Colonization of NC is considered the cause of 50% of postinsertion catheter-related infections. Breaks in aseptic technique, from failure to disinfect, result in contamination and subsequent biofilm formation within NC and catheters increasing the potential for infection of central and peripheral catheters. Methods. This systematic review evaluated 140 studies and 34 abstracts on NC disinfection practices, the impact of hub contamination on infection, and measures of education and compliance. Results. The greatest risk for contamination of the catheter after insertion is the NC with 33–45% contaminated, and compliance with disinfection as low as 10%. The optimal technique or disinfection time has not been identified, although scrubbing with 70% alcohol for 5–60 seconds is recommended. Studies have reported statistically significant results in infection reduction when passive alcohol disinfection caps are used (48–86% reduction. Clinical Implications. It is critical for healthcare facilities and clinicians to take responsibility for compliance with basic principles of asepsis compliance, to involve frontline staff in strategies, to facilitate education that promotes understanding of the consequences of failure, and to comply with the standard of care for hub disinfection.

  8. Design and Development of an Integrated Workstation Automation Hub

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Andrew; Ghatikar, Girish; Sartor, Dale; Lanzisera, Steven

    2015-03-30

    Miscellaneous Electronic Loads (MELs) account for one third of all electricity consumption in U.S. commercial buildings, and are drivers for a significant energy use in India. Many of the MEL-specific plug-load devices are concentrated at workstations in offices. The use of intelligence, and integrated controls and communications at the workstation for an Office Automation Hub – offers the opportunity to improve both energy efficiency and occupant comfort, along with services for Smart Grid operations. Software and hardware solutions are available from a wide array of vendors for the different components, but an integrated system with interoperable communications is yet to be developed and deployed. In this study, we propose system- and component-level specifications for the Office Automation Hub, their functions, and a prioritized list for the design of a proof-of-concept system. Leveraging the strength of both the U.S. and India technology sectors, this specification serves as a guide for researchers and industry in both countries to support the development, testing, and evaluation of a prototype product. Further evaluation of such integrated technologies for performance and cost is necessary to identify the potential to reduce energy consumptions in MELs and to improve occupant comfort.

  9. A comprehensive vibration analysis of a coupled rotor/fuselage system

    Science.gov (United States)

    Yeo, Hyeonsoo

    A comprehensive vibration analysis of a coupled rotor/fuselage system for a two-bladed teetering rotor using finite element methods in space and time is developed which incorporates consistent rotor/fuselage structural, aerodynamic, and inertial couplings and a modern free wake model. A coordinate system is developed to take into account a teetering rotor's unique characteristics, such as teetering motion and undersling. Coupled nonlinear periodic blade and fuselage equations are transformed to the modal space in the fixed frame and solved simultaneously. The elastic line and detailed 3-D NASTRAN finite element models of the AH-1G helicopter airframe from the DAMVIBS program are integrated into the elastic rotor finite element model. Analytical predictions of rotor control angles, blade loads, hub forces, and vibration are compared with AH-1G Operation Load Survey flight test data. The blade loads predicted by present analysis show generally fair agreement with the flight test data, especially blade chord bending moment estimation shows good agreement. Calculated 2/rev vertical vibration levels at pilot seat show good correlation with the flight test data both in magnitude and phase, but 4/rev vibration levels show fair correlation only in magnitude. Lateral vibration results show more disagreement than vertical vibration results. Pylon flexibility effect is essential in the two-bladed teetering rotor vibration analysis. The pylon flexibility increases the first lag frequency by about 14%, and decreases 2/rev longitudinal and lateral hub forces by more than half. Rotor/fuselage coupling reduces 2/rev vertical and lateral vibration levels by 60% to 70% and has a small effect on 4/rev vibration levels. Modeling of difficult components (secondary structures, doors/panels, etc) is essential in predicting airframe natural frequencies. Refined aerodynamics such as free wake and unsteady aerodynamics have an important role in the prediction of vibration. For example, free

  10. Knowledge Hub y los recursos educativos abiertos en Contaduría

    OpenAIRE

    Farías Martínez, Gabriela María

    2010-01-01

    Desafíos de la educación superior en México; Formación académica y profesional en contaduría; Knowledge Hub como medio para compartir y construir conocimiento; Iniciativa Knowledge Hub IES Contaduría

  11. 14 CFR 158.30 - PFC Authorization at Non-Hub Airports.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false PFC Authorization at Non-Hub Airports. 158... (CONTINUED) AIRPORTS PASSENGER FACILITY CHARGES (PFC'S) Application and Approval § 158.30 PFC Authorization at Non-Hub Airports. (a) General. This section specifies the procedures a public agency controlling...

  12. The Complexities and Challenges of Regional Education Hubs: Focus on Malaysia

    Science.gov (United States)

    Knight, Jane; Morshidi, Sirat

    2011-01-01

    The race to establish regional education hubs is a recent development in cross-border higher education. This article briefly examines the rationales and strategies used by three countries in the Middle East and three in South East Asia which are working towards positioning themselves as regional education hubs. The different approaches and…

  13. Knowledge Hub y los recursos educativos abiertos en Contaduría

    OpenAIRE

    Farías Martínez, Gabriela María

    2013-01-01

    Desafíos de la educación superior en México; Formación académica y profesional en contaduría; Knowledge Hub como medio para compartir y construir conocimiento; Iniciativa Knowledge Hub IES Contaduría

  14. A multi-objective imperialist competitive algorithm for a capacitated hub covering location problem

    Directory of Open Access Journals (Sweden)

    M. Mohammadi

    2011-01-01

    Full Text Available The hub location problem appears in a variety of applications, including airline systems, cargo delivery systems and telecommunication network design. Hub location problems deal with finding the location of hub facilities and the allocation of demand nodes to these located hub facilities. In this paper, a new model for the capacitated single allocation hub covering location problem is presented. Instead of using capacity constraints to limit the amount of flow received by the hubs, the second objective function is introduced to minimize service times in the hubs. The service time in the hubs includes the waiting time of received flows in a queue and the time to get services. Due to the NP-hardness of the problem, a new weight-based multi-objective imperialist competitive algorithm (MOICA is designed to find near-optimal solutions. To validate the performance of the proposed algorithm, the solutions obtained by the MOICA are compared by the exact solutions of the mathematical programming model.

  15. Domestic Output of Aluminium Alloy Hub Surpassing 70 million in 2007

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>According to a report from the hub branch of China Association of Automobile Manufactur- ers,China has produced a total of more than 70 million aluminium alloy hubs in 2007,a year- on-year growth over 25%,while consuming over 700,000 tons of primary aluminium the whole year.

  16. Optimal Scheduling of a Multi-Carrier Energy Hub Supplemented By Battery Energy Storage Systems

    DEFF Research Database (Denmark)

    Javadi, Mohammad Sadegh; Anvari-Moghaddam, Amjad; Guerrero, Josep M.

    2017-01-01

    This paper introduces a management model for optimal scheduling of a multi-carrier energy hub. In the proposed hub, three types of assets are considered: dispersed generating systems (DGs) such as micro-combined heat and power (mCHP) units, storage devices such as battery-based electrical storage...

  17. Network performance, hub connectivity potential, and competitive position of primary airports in Asia/Pacific region

    NARCIS (Netherlands)

    Matsumoto, H.; Veldhuis, J.; de Wit, J.; Burghouwt, G.

    2008-01-01

    Recently, hub-and-spoke network configurations are more and more developed in the Asia/Pacific region. In this paper, it is argued that the measurement of network performance in hub-and-spoke systems should take into account the quantity and quality of both direct and indirect connections. The NetSc

  18. The Complexities and Challenges of Regional Education Hubs: Focus on Malaysia

    Science.gov (United States)

    Knight, Jane; Morshidi, Sirat

    2011-01-01

    The race to establish regional education hubs is a recent development in cross-border higher education. This article briefly examines the rationales and strategies used by three countries in the Middle East and three in South East Asia which are working towards positioning themselves as regional education hubs. The different approaches and…

  19. Competition and coordination in the U.S. airline hub-to-hub markets: An industry pre-merger case study

    Directory of Open Access Journals (Sweden)

    Prasun Bhattacharjee

    2016-04-01

    Full Text Available Purpose: This paper investigates the nature of conduct that existed in the U.S. airline hub-to-hub markets prior to the recent merger wave of the legacy carriers. We explore the strategic importance of network carrier hubs in form of “spheres of influence” on airline market conduct. We also simultaneously recognize the overgrowing role played by Low Cost Carriers (LCC over the years by estimating two conduct parameters - one in markets where LCCs directly compete head-to-head with legacy carriers and the other for markets which LCCs do not serve but has presence in the hub airports or adjacent airports comprising the market endpoints. Thus our supply side framework also sheds some light on the issue of perfect contestability in airline industry. Design/methodology/approach: We estimate a structural oligopoly model for differentiated products with competitive interactions using DB1B data for first quarter of 2004. Findings: Our results imply that the nature of competition is more aggressive relative to Bertrand behavior in hub-to-hub markets and that these markets are less than perfectly contestable. Originality/value: This paper adds to the empirical literature of airline competition by enabling estimation of the actual conduct parameter assuming firm price setting behavior in presence of product differentiation. Contrary to existing literature on airline competition, a structural model enables us to systematically separate out effects of demand, cost and strategic factors on observed airline prices.

  20. Features analysis for identification of date and party hubs in protein interaction network of Saccharomyces Cerevisiae

    Directory of Open Access Journals (Sweden)

    Araabi Babak N

    2010-12-01

    Full Text Available Abstract Background It has been understood that biological networks have modular organizations which are the sources of their observed complexity. Analysis of networks and motifs has shown that two types of hubs, party hubs and date hubs, are responsible for this complexity. Party hubs are local coordinators because of their high co-expressions with their partners, whereas date hubs display low co-expressions and are assumed as global connectors. However there is no mutual agreement on these concepts in related literature with different studies reporting their results on different data sets. We investigated whether there is a relation between the biological features of Saccharomyces Cerevisiae's proteins and their roles as non-hubs, intermediately connected, party hubs, and date hubs. We propose a classifier that separates these four classes. Results We extracted different biological characteristics including amino acid sequences, domain contents, repeated domains, functional categories, biological processes, cellular compartments, disordered regions, and position specific scoring matrix from various sources. Several classifiers are examined and the best feature-sets based on average correct classification rate and correlation coefficients of the results are selected. We show that fusion of five feature-sets including domains, Position Specific Scoring Matrix-400, cellular compartments level one, and composition pairs with two and one gaps provide the best discrimination with an average correct classification rate of 77%. Conclusions We study a variety of known biological feature-sets of the proteins and show that there is a relation between domains, Position Specific Scoring Matrix-400, cellular compartments level one, composition pairs with two and one gaps of Saccharomyces Cerevisiae's proteins, and their roles in the protein interaction network as non-hubs, intermediately connected, party hubs and date hubs. This study also confirms the

  1. Effective spectral dimension of hub in scale-free networks

    Science.gov (United States)

    Hwang, Sungmin; Lee, Deok-Sun; Kahng, Byungnam

    2012-02-01

    Exploring the World Wide Web has become one of the key issues in information science, specifically in context of its application to the PageRank-like algorithms used in search engine. The random walk approach has been employed to study such a problem. The probability of the return to the origin (RTO) of random walks is inversely related to how information can be accessed during random surfing. We find analytically that the RTO probability for a given starting node shows a crossover from a slow to a fast decay behavior with time and the crossover time increases with the degree of the starting node. Furthermore, the RTO probability is almost constant in the early-time regime as the degree exponent approaches two. This result indicates that a random surfer can be effectively trapped at the hub and supports the necessity of the random jump strategy empirically used in the Google's search engine.

  2. Paneth cells: the hub for sensing and regulating intestinal flora.

    Science.gov (United States)

    Zhang, Zheng; Liu, Zhihua

    2016-05-01

    The complex interplay between symbiotic bacteria and host immunity plays a key role in shaping intestinal homeostasis and maintaining host health. Paneth cells, as one of the major producers of antimicrobial peptides in the intestine under steady-state conditions, play a vital role in regulating intestinal flora. Many studies on inflammatory bowel disease (IBD)-associated genes have put Paneth cells at the center of IBD pathogenesis. In this perspective, we focus on mechanistic studies of different cellular processes in Paneth cells that are regulated by various IBD-associated susceptibility genes, and we discuss the hypothesis that Paneth cells function as the central hub for sensing and regulating intestinal flora in the maintenance of intestinal homeostasis.

  3. A Collaborative Scheduling Model for the Supply-Hub with Multiple Suppliers and Multiple Manufacturers

    Directory of Open Access Journals (Sweden)

    Guo Li

    2014-01-01

    Full Text Available This paper investigates a collaborative scheduling model in the assembly system, wherein multiple suppliers have to deliver their components to the multiple manufacturers under the operation of Supply-Hub. We first develop two different scenarios to examine the impact of Supply-Hub. One is that suppliers and manufacturers make their decisions separately, and the other is that the Supply-Hub makes joint decisions with collaborative scheduling. The results show that our scheduling model with the Supply-Hub is a NP-complete problem, therefore, we propose an auto-adapted differential evolution algorithm to solve this problem. Moreover, we illustrate that the performance of collaborative scheduling by the Supply-Hub is superior to separate decision made by each manufacturer and supplier. Furthermore, we also show that the algorithm proposed has good convergence and reliability, which can be applicable to more complicated supply chain environment.

  4. Hub Identification of the Metro Manila Road Network Using PageRank

    CERN Document Server

    Chan, Jacob

    2016-01-01

    We attempt to identify the different node hubs of a road network using PageRank for preparation for possible random terrorist attacks. The robustness of a road network against such attack is crucial to be studied because it may cripple its connectivity by simply shutting down these hubs. We show the important hubs in a road network based on network structure and propose a model for robustness analysis. By identifying important hubs in a road network, possible preparation schemes may be done earlier to mitigate random terrorist attacks, including defense reinforcement and transportation security. A case study of the Metro Manila road network is also presented. The case study shows that the most important hubs in the Metro Manila road network are near airports, piers, major highways and expressways

  5. A Fractal and Scale-free Model of Complex Networks with Hub Attraction Behaviors

    CERN Document Server

    Kuang, Li; Li, Deyi; Li, Yuanxiang; Sun, Yu

    2013-01-01

    It is widely believed that fractality of complex networks origins from hub repulsion behaviors (anticorrelation or disassortativity), which means large degree nodes tend to connect with small degree nodes. This hypothesis was demonstrated by a dynamical growth model, which evolves as the inverse renormalization procedure proposed by Song et al. Now we find that the dynamical growth model is based on the assumption that all the cross-boxes links has the same probability e to link to the most connected nodes inside each box. Therefore, we modify the growth model by adopting the flexible probability e, which makes hubs have higher probability to connect with hubs than non-hubs. With this model, we find some fractal and scale-free networks have hub attraction behaviors (correlation or assortativity). The results are the counter-examples of former beliefs.

  6. MODELS AND METHODS FOR LOGISTICS HUB LOCATION: A REVIEW TOWARDS TRANSPORTATION NETWORKS DESIGN

    Directory of Open Access Journals (Sweden)

    Carolina Luisa dos Santos Vieira

    Full Text Available ABSTRACT Logistics hubs affect the distribution patterns in transportation networks since they are flow-concentrating structures. Indeed, the efficient moving of goods throughout supply chains depends on the design of such networks. This paper presents a literature review on the logistics hub location problem, providing an outline of modeling approaches, solving techniques, and their applicability to such context. Two categories of models were identified. While multi-criteria models may seem best suited to find optimal locations, they do not allow an assessment of the impact of new hubs on goods flow and on the transportation network. On the other hand, single-criterion models, which provide location and flow allocation information, adopt network simplifications that hinder an accurate representation of the relationshipbetween origins, destinations, and hubs. In view of these limitations we propose future research directions for addressing real challenges of logistics hubs location regarding transportation networks design.

  7. Electricity hubs and market centers: A new business tool for electric utilities?

    Energy Technology Data Exchange (ETDEWEB)

    Vallen, M.A.; Sharp, L.S. [Univ. of Toledo, OH (United States)

    1995-07-01

    There are many complexities clouding the use of hubs and market centers in the electricity market, but lessons learned in the natural gas industry can save a lot of unnecessary reinvention. The bottom line: Electricity hubs and market centers will allow the markets to work most efficiently. This article will describe how regional trading hubs may function in the competitive electricity market, using the experiences of the natural gas market to illustrate the principles involved. Part I will define the typical characteristics of hubs and market centers and describe the dey success factors needed to develop a new market center. Part II will describe the types of products and services that an electricity hub or marketing center will need to offer to succeed.

  8. USDA Southwest Regional Hub for Adaptation to and Mitigation of Climate Change

    Science.gov (United States)

    Rango, A.; Elias, E.; Steele, C. M.; Havstad, K.

    2014-12-01

    The USDA Southwest (SW) Climate Hub was created in February 2014 to develop risk adaptation and mitigation strategies for coping with climate change effects on agricultural productivity. There are seven regional hubs across the country with three subsidiary hubs. The SW Climate Hub Region is made up of six states: New Mexico, Arizona, Utah, Nevada, California and Hawaii (plus the Trust Territories of the Pacific Islands). The SW Climate Hub has a subsidiary hub located in Davis, California. The Southwest region has high climatic diversity, with the lowest and highest average annual rainfall in the U.S.(6.0 cm in Death Valley, CA and 1168 cm at Mt. Waialeale, HI). There are major deserts in five of the six states, yet most of the states, with exception of Hawaii, depend upon the melting of mountain snowpacks for their surface water supply. Additionally, many of the agricultural areas of the SW Regional Hub depend upon irrigation water to maintain productivity. Scientific climate information developed by the Hub will be used for climate-smart decision making. To do this, the SW Regional Hub will rely upon existing infrastructure of the Cooperative Extension Service at Land-Grant State Universities. Extension service and USDA-NRCS personnel have existing networks to communicate with stakeholders (farmers, ranchers, and forest landowners) through meetings and workshops which have already started in the six states. Outreach through the development of a weather and climate impact modules designed for seventh grade students and their teachers will foster education of future generations of rural land managers. We will be synthesizing and evaluating existing reports, literature and information on regional climate projections, water resources, and agricultural adaptation strategies related to climate in the Southwest. The results will be organized in a spatial format and provided through the SW Hub website (http://swclimatehub.info) and peer-reviewed articles.

  9. The noise generated by a landing gear wheel with hub and rim cavities

    Science.gov (United States)

    Wang, Meng; Angland, David; Zhang, Xin

    2017-03-01

    Wheels are one of the major noise sources of landing gears. Accurate numerical predictions of wheel noise can provide an insight into the physical mechanism of landing gear noise generation and can aid in the design of noise control devices. The major noise sources of a 33% scaled isolated landing gear wheel are investigated by simulating three different wheel configurations using high-order numerical simulations to compute the flow field and the FW-H equation to obtain the far-field acoustic pressures. The baseline configuration is a wheel with a hub cavity and two rim cavities. Two additional simulations are performed; one with the hub cavity covered (NHC) and the other with both the hub cavity and rim cavities covered (NHCRC). These simulations isolate the effects of the hub cavity and rim cavities on the overall wheel noise. The surface flow patterns are visualised by shear stress lines and show that the flow separations and attachments on the side of the wheel, in both the baseline and the configuration with only the hub cavity covered, are significantly reduced by covering both the hub and rim cavities. A frequency-domain FW-H equation is used to identify the noise source regions on the surface of the wheel. The tyre is the main low frequency noise source and shows a lift dipole and side force dipole pattern depending on the frequency. The hub cavity is identified as the dominant middle frequency noise source and radiates in a frequency range centered around the first and second depth modes of the cylindrical hub cavity. The rim cavities are the main high-frequency noise sources. With the hub cavity and rim cavities covered, the largest reduction in Overall Sound Pressure Level (OASPL) is achieved in the hub side direction. In the other directivities, there is also a reduction in the radiated sound.

  10. Connectome hubs at resting state in children and adolescents: Reproducibility and psychopathological correlation

    Directory of Open Access Journals (Sweden)

    João Ricardo Sato

    2016-08-01

    Full Text Available Functional brain hubs are key integrative regions in brain networks. Recently, brain hubs identified through resting-state fMRI have emerged as interesting targets to increase understanding of the relationships between large-scale functional networks and psychopathology. However, few studies have directly addressed the replicability and consistency of the hub regions identified and their association with symptoms. Here, we used the eigenvector centrality (EVC measure obtained from graph analysis of two large, independent population-based samples of children and adolescents (7–15 years old; total N = 652; 341 subjects for site 1 and 311 for site 2 to evaluate the replicability of hub identification. Subsequently, we tested the association between replicable hub regions and psychiatric symptoms. We identified a set of hubs consisting of the anterior medial prefrontal cortex and inferior parietal lobule/intraparietal sulcus (IPL/IPS. Moreover, lower EVC values in the right IPS were associated with psychiatric symptoms in both samples. Thus, low centrality of the IPS was a replicable sign of potential vulnerability to mental disorders in children. The identification of critical and replicable hubs in functional cortical networks in children and adolescents can foster understanding of the mechanisms underlying mental disorders.

  11. Connectome hubs at resting state in children and adolescents: Reproducibility and psychopathological correlation.

    Science.gov (United States)

    Sato, João Ricardo; Biazoli, Claudinei Eduardo; Salum, Giovanni Abrahão; Gadelha, Ary; Crossley, Nicolas; Vieira, Gilson; Zugman, André; Picon, Felipe Almeida; Pan, Pedro Mario; Hoexter, Marcelo Queiroz; Anés, Mauricio; Moura, Luciana Monteiro; Del'Aquilla, Marco Antonio Gomes; Junior, Edson Amaro; Mcguire, Philip; Rohde, Luis Augusto; Miguel, Euripedes Constantino; Bressan, Rodrigo Affonseca; Jackowski, Andrea Parolin

    2016-08-01

    Functional brain hubs are key integrative regions in brain networks. Recently, brain hubs identified through resting-state fMRI have emerged as interesting targets to increase understanding of the relationships between large-scale functional networks and psychopathology. However, few studies have directly addressed the replicability and consistency of the hub regions identified and their association with symptoms. Here, we used the eigenvector centrality (EVC) measure obtained from graph analysis of two large, independent population-based samples of children and adolescents (7-15 years old; total N=652; 341 subjects for site 1 and 311 for site 2) to evaluate the replicability of hub identification. Subsequently, we tested the association between replicable hub regions and psychiatric symptoms. We identified a set of hubs consisting of the anterior medial prefrontal cortex and inferior parietal lobule/intraparietal sulcus (IPL/IPS). Moreover, lower EVC values in the right IPS were associated with psychiatric symptoms in both samples. Thus, low centrality of the IPS was a replicable sign of potential vulnerability to mental disorders in children. The identification of critical and replicable hubs in functional cortical networks in children and adolescents can foster understanding of the mechanisms underlying mental disorders.

  12. Incremental Optimization of Hub and Spoke Network for the Spokes’ Numbers and Flow

    Directory of Open Access Journals (Sweden)

    Yanfeng Wang

    2015-01-01

    Full Text Available Hub and spoke network problem is solved as part of a strategic decision making process which may have a profound effect on the future of enterprises. In view of the existing network structure, as time goes on, the number of spokes and the flow change because of different sources of uncertainty. Hence, the incremental optimization of hub and spoke network problem is considered in this paper, and the policy makers should adopt a series of strategies to cope with the change, such as setting up new hubs, adjusting the capacity level of original hubs, or closing some original hubs. The objective is to minimize the total cost, which includes the setup costs for the new hubs, the closure costs, and the adjustment costs for the original hubs as well as the flow routing costs. Two mixed-integer linear programming formulations are proposed and analyzed for this problem. China Deppon Logistics as an example is performed to present computational analysis, and we analyze the changes in the solutions driven by the number of spokes and the flow. The tests also allow an analysis to consider the effect of variation in parameters on network.

  13. Fatigue based design and analysis of wheel hub for Student formula car by Simulation Approach

    Science.gov (United States)

    Gowtham, V.; Ranganathan, A. S.; Satish, S.; Alexis, S. John; Siva kumar, S.

    2016-09-01

    In the existing design of Wheel hub used for Student formula cars, the brake discs cannot be removed easily since the disc is mounted in between the knuckle and hub. In case of bend or any other damage to the disc, the replacement of the disc becomes difficult. Further using OEM hub and knuckle that are used for commercial vehicles will result in increase of unsprung mass, which should be avoided in Student formula cars for improving the performance. In this design the above mentioned difficulties have been overcome by redesigning the hub in such a way that the brake disc could be removed easily by just removing the wheel and the caliper and also it will have reduced weight when compared to existing OEM hub. A CAD Model was developed based on the required fatigue life cycles. The forces acting on the hub were calculated and linear static structural analysis was performed on the wheel hub for three different materials using ANSYS Finite Element code V 16.2. The theoretical fatigue strength was compared with the stress obtained from the structural analysis for each material.

  14. A multidomain hub anchors the chromosome segregation and chemotactic machinery to the bacterial pole.

    Science.gov (United States)

    Yamaichi, Yoshiharu; Bruckner, Raphael; Ringgaard, Simon; Möll, Andrea; Cameron, D Ewen; Briegel, Ariane; Jensen, Grant J; Davis, Brigid M; Waldor, Matthew K

    2012-10-15

    The cell poles constitute key subcellular domains that are often critical for motility, chemotaxis, and chromosome segregation in rod-shaped bacteria. However, in nearly all rods, the processes that underlie the formation, recognition, and perpetuation of the polar domains are largely unknown. Here, in Vibrio cholerae, we identified HubP (hub of the pole), a polar transmembrane protein conserved in all vibrios, that anchors three ParA-like ATPases to the cell poles and, through them, controls polar localization of the chromosome origin, the chemotactic machinery, and the flagellum. In the absence of HubP, oriCI is not targeted to the cell poles, chemotaxis is impaired, and a small but increased fraction of cells produces multiple, rather than single, flagella. Distinct cytoplasmic domains within HubP are required for polar targeting of the three ATPases, while a periplasmic portion of HubP is required for its localization. HubP partially relocalizes from the poles to the mid-cell prior to cell division, thereby enabling perpetuation of the polar domain in future daughter cells. Thus, a single polar hub is instrumental for establishing polar identity and organization.

  15. Hubs and authorities in the world trade network using a weighted HITS algorithm.

    Science.gov (United States)

    Deguchi, Tsuyoshi; Takahashi, Katsuhide; Takayasu, Hideki; Takayasu, Misako

    2014-01-01

    We investigate the economic hubs and authorities of the world trade network (WTN) from 1992 to 2012, an era of rapid economic globalization. Using a well-defined weighted hyperlink-induced topic search (HITS) algorithm, we can calculate the values of the weighted HITS hub and authority for each country in a conjugate way. In the context of the WTN, authority values are large for countries with significant imports from large hub countries, and hub values are large for countries with significant exports to high-authority countries. The United States was the largest economic authority in the WTN from 1992 to 2012. The authority value of the United States has declined since 2001, and China has now become the largest hub in the WTN. At the same time, China's authority value has grown as China is transforming itself from the "factory of the world" to the "market of the world." European countries show a tendency to trade mostly within the European Union, which has decreased Europe's hub and authority values. Japan's authority value has increased slowly, while its hub value has declined. These changes are consistent with Japan's transition from being an export-driven economy in its high economic growth era in the latter half of the twentieth century to being a more mature, economically balanced nation.

  16. Hubs and authorities in the world trade network using a weighted HITS algorithm.

    Directory of Open Access Journals (Sweden)

    Tsuyoshi Deguchi

    Full Text Available We investigate the economic hubs and authorities of the world trade network (WTN from 1992 to 2012, an era of rapid economic globalization. Using a well-defined weighted hyperlink-induced topic search (HITS algorithm, we can calculate the values of the weighted HITS hub and authority for each country in a conjugate way. In the context of the WTN, authority values are large for countries with significant imports from large hub countries, and hub values are large for countries with significant exports to high-authority countries. The United States was the largest economic authority in the WTN from 1992 to 2012. The authority value of the United States has declined since 2001, and China has now become the largest hub in the WTN. At the same time, China's authority value has grown as China is transforming itself from the "factory of the world" to the "market of the world." European countries show a tendency to trade mostly within the European Union, which has decreased Europe's hub and authority values. Japan's authority value has increased slowly, while its hub value has declined. These changes are consistent with Japan's transition from being an export-driven economy in its high economic growth era in the latter half of the twentieth century to being a more mature, economically balanced nation.

  17. 合成气中枢%Syngas Hub

    Institute of Scientific and Technical Information of China (English)

    徐恒泳; 葛庆杰; 李文钊

    2011-01-01

    回顾了人类使用化石能源所经历的煤(固体)、石油(液体)和天然气(气体)燃料的3个时期.针对近年来环境安全和能源清洁化日益重要,而化石能源仍占世界能源主要消费结构的现状,提出了“合成气中枢”的新概念.重点介绍了从天然气、煤和生物质等多种原料气化生产合成气并进行组成调变;煤基和天然气基合成气制化学品的差别;合成气的转化利用,特别是在发电和热-电-化学品多联产、制取清洁燃料和烯烃以及制取代用天然气等方面的研究进展并进行了评述.认为合成气中枢将成为连接石油炼制、石油化工、天然气化工和煤化工以及电力行业的桥梁,有利于资源和能量的最佳利用以及CO2减排.%The consumption history of fossil energy sources including coal ( solid), petroleum (liquid) and natural gas (gas) was briefly reviewed. Although the seeking for non-fossil energy sources is becoming urgent due to the more and more serious global warming, the fossil energy sources will still occupy more than 50% of the global energy consumption before 2050. Therefore, the concept of syngas hub was brought forward, and the following aspects were emphasized in this review: syngas production and its composition adjustment, the difference of syngas to chemicals from coal and natural gas, and syngas conversion and utilization. It was thought that the syngas hub will become a bridge which connects petroleum refining, petrochemical industry, natural gas chemical industry, coal chemical industry and electric power industry, and is further beneficial to the low CO2 emission and the optimal utilization of resources and energy sources.

  18. On the Popularity of GitHub Applications: A Preliminary Note

    OpenAIRE

    Borges, Hudson; Valente, Marco Tulio; Hora, Andre; Coelho, Jailton

    2015-01-01

    GitHub is the world's largest collection of open source software. Therefore, it is important both to software developers and users to compare and track the popularity of GitHub repositories. In this paper, we propose a framework to assess the popularity of GitHub software, using their number of stars. We also propose a set of popularity growth patterns, which describe the evolution of the number of stars of a system over time. We show that stars tend to correlate with other measures, like for...

  19. Assessing wave energy effects on biodiversity: the wave hub experience.

    Science.gov (United States)

    Witt, M J; Sheehan, E V; Bearhop, S; Broderick, A C; Conley, D C; Cotterell, S P; Crow, E; Grecian, W J; Halsband, C; Hodgson, D J; Hosegood, P; Inger, R; Miller, P I; Sims, D W; Thompson, R C; Vanstaen, K; Votier, S C; Attrill, M J; Godley, B J

    2012-01-28

    Marine renewable energy installations harnessing energy from wind, wave and tidal resources are likely to become a large part of the future energy mix worldwide. The potential to gather energy from waves has recently seen increasing interest, with pilot developments in several nations. Although technology to harness wave energy lags behind that of wind and tidal generation, it has the potential to contribute significantly to energy production. As wave energy technology matures and becomes more widespread, it is likely to result in further transformation of our coastal seas. Such changes are accompanied by uncertainty regarding their impacts on biodiversity. To date, impacts have not been assessed, as wave energy converters have yet to be fully developed. Therefore, there is a pressing need to build a framework of understanding regarding the potential impacts of these technologies, underpinned by methodologies that are transferable and scalable across sites to facilitate formal meta-analysis. We first review the potential positive and negative effects of wave energy generation, and then, with specific reference to our work at the Wave Hub (a wave energy test site in southwest England, UK), we set out the methodological approaches needed to assess possible effects of wave energy on biodiversity. We highlight the need for national and international research clusters to accelerate the implementation of wave energy, within a coherent understanding of potential effects-both positive and negative.

  20. Proof test of hybrid shrink fits with ceramic hub

    Science.gov (United States)

    Wagner, M.; Binz, H.

    2011-10-01

    Advanced ceramic machine components are required in many applications because of their specific material properties like high hardness, resistance to chemicals, corrosion and wear, low specific weight etc. The most suitable shaft-hub connection to ceramics is an interference fit assembly because it is free of geometrical notches and transmission of forces takes place in a large area. Such a shrink fit is rated for endurance strength when the stress intensity factor is below the specific value KI0 where no crack growth occurs. The total component suddenly fails, when the stress intensity factor exceeds the KIC value. The load to the press fit during the joining process, caused by the interference of the assembly, could be regulated by ambient conditions. In case of undetected material defects or microcracks in the ceramic and if the stress intensity is below KIC, the ceramic will not fail but a crack could grow. Thus, the joining process only seems to be a proof test. When the load during operation leads to a stress intensity that remains higher than KI0 the crack grows until the whole ceramic component fails. This effect was verified in tests at the Institute for Engineering Design and Industrial Design.

  1. Proof test of hybrid shrink fits with ceramic hub

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, M; Binz, H, E-mail: markus.wagner@iktd.uni-stuttgart.de [Institute for Engineering Design and Industrial Design, University of Stuttgart (Germany)

    2011-10-29

    Advanced ceramic machine components are required in many applications because of their specific material properties like high hardness, resistance to chemicals, corrosion and wear, low specific weight etc. The most suitable shaft-hub connection to ceramics is an interference fit assembly because it is free of geometrical notches and transmission of forces takes place in a large area. Such a shrink fit is rated for endurance strength when the stress intensity factor is below the specific value K{sub I0} where no crack growth occurs. The total component suddenly fails, when the stress intensity factor exceeds the K{sub IC} value. The load to the press fit during the joining process, caused by the interference of the assembly, could be regulated by ambient conditions. In case of undetected material defects or microcracks in the ceramic and if the stress intensity is below K{sub IC}, the ceramic will not fail but a crack could grow. Thus, the joining process only seems to be a proof test. When the load during operation leads to a stress intensity that remains higher than K{sub I0} the crack grows until the whole ceramic component fails. This effect was verified in tests at the Institute for Engineering Design and Industrial Design.

  2. Modelagem para localização de hubs no transporte de encomendas expressas Modelling for location hubs in the express cargo transport

    Directory of Open Access Journals (Sweden)

    Javier Antonio Timaná Alamo

    2006-12-01

    Full Text Available Na presente pesquisa se propõe um modelo matemático de programação linear com variáveis binárias 0/1, para projetar a configuração de uma rede de distribuição de encomendas expressas, visando minimizar os custos e garantindo um bom nível de serviço. O modelo, que é uma modificação da formulação proposta por O’Kelly, define as posições dos hubs, a alocação deles às demais instalações físicas e a construção de roteiros com apenas uma parada intermediária, o que confere mais agilidade ao atendimento da demanda de transporte de carga. Considera-se a instalação de um único hub maior (Hub Principal, que serve como ponto de transbordo para os fluxos de carga entre as distintas regiões de um território, e um conjunto de terminais regionais (mini-hubs, servindo como ponto de conexão, unicamente, para os fluxos de carga existentes em um determinado raio de cobertura. Foram propostas extensões que incluem uma restrição da capacidade operacional do Hub Principal, para evitar seu congestionamento, e duas diferentes estratégias de induzir o aumento de fluxo de carga manipulado pelos mini-hubs. O modelo proposto e suas extensões foram aplicados ao estudo de um caso real, obtendo-se resultados consistentes e uma redução significativa no custo total da rede de distribuição da empresa analisada.This study proposes a mathematical model of linear programming with binary variables 0/1 to project the configuration of a distribution network for express cargo which aims to minimize costs and guarantee a high level of service. The model, which is a modification of the formulation proposed by O’Kelly, defines the position of the hubs, their allocation regarding the other physical installations, and the building of itineraries with only one intermediate stop, which increases agility in meeting the demand of cargo transport. It assumes the installation of a single, major hub (Main Hub, which serves as the transfer point for

  3. The hub wall boundary layer development and losses in an axial flow compressor rotor passage

    Science.gov (United States)

    Murthy, K. N. S.; Lakshminarayana, B.

    1987-02-01

    The hub wall boundary layer development in a compressor stage including the rotor passage is experimentally investigated. A miniature five-hole probe was employed to measure the hub wall boundary layer inside the inlet guide vane passage, upstream and far downstream of the rotor. The hub wall boundary layer inside the rotor passage was acquired using a rotating miniature five-hole probe. The boundary layer is well behaved upstream and far downstream of the rotor. The migration of the hub wall boundary layer towards the suction surface corner is observed. The limiting streamline angles and static pressure distribution across the stage were also measured. The mean velocity profiles and the integral properties upstream, inside and downstream of the rotor, and the losses are presented and interpreted.

  4. Numerical and Experimental Investigation of Heat Flow in Permanent Magnet Brushless DC Hub Motor

    DEFF Research Database (Denmark)

    Fasil, Muhammed; Plesner, Daniel; Walther, Jens Honore

    2014-01-01

    in the stator. The hub motor construction restricts the available conductive paths for heat dissipation from the stator to the ambient only through the shaft. In contrast to an internal rotor structure, where the stator winding losses are diffused via conduction, here convection plays a major role in loss...... dissipation. Therefore, a LP thermal model with improved convection modelling has been proposed to calculate the temperature of the components inside the hub motor. The developed model is validated with the FE thermal model and the test data. In addition, CFD tools has been used to accurately model...... the internal and the external flow as well as the convective heat transfer of the hub motor. Finally, an optimization study of the hub motor has been carried out using the CFD model to improve heat transfer from the stator....

  5. Collaborative Policy of the Supply-Hub for Assemble-to-Order Systems with Delivery Uncertainty

    Directory of Open Access Journals (Sweden)

    Guo Li

    2014-01-01

    Full Text Available This paper considers the collaborative mechanisms of the Supply-Hub in the Assemble-to-Order system (ATO system hereafter with upstream delivery uncertainty. We first propose a collaborative replenishment mechanism in the ATO system, and construct a replenishment model with delivery uncertainty in use of the Supply-Hub. After transforming the original model into a one-dimensional optimization problem, we derive the optimal assembly quantity and reorder point of each component. In order to enable the Supply-Hub to conduct collaborative replenishment with each supplier, the punishment and reward mechanisms are proposed. The numerical analysis illustrates that service level of the Supply-Hub is an increasing function of both punishment and reward factors. Therefore, by adjusting the two factors, suppliers’ incentives of collaborative replenishment can be significantly enhanced, and then the service level of whole ATO system can be improved.

  6. Puertos, espacio y globalización: el desarrollo de hubs en México

    Directory of Open Access Journals (Sweden)

    Carlos Daniel Martner Peyrelongue

    2010-01-01

    Full Text Available Los puertos hubs se presentan como el nuevo paradigma de desarrollo del transporte y el comercio marítimo internacional en la globalización. Prácticamente todos los países latinoamericanos anuncian megaproyectos para el desarrollo de puertos hubs en sus litorales, generando grandes expectativas de desarrollo regional, con un débil sustento tanto teórico como empírico. En este sentido, el presente trabajo busca contribuir a la caracterización del modelo de puertos hubs en países periféricos dentro de la economíamundo capitalista, aludiendo, en especial, al caso mexicano. Se trata de aportar elementos de análisis para reconocer, a grandes rasgos, las posibilidades del desarrollo de hubs en los litorales mexicanos, desde la perspectiva de los estudios regionales y la geografía del transporte.

  7. Empirical analysis on the human dynamics of blogging behavior on GitHub

    Science.gov (United States)

    Yan, Deng-Cheng; Wei, Zong-Wen; Han, Xiao-Pu; Wang, Bing-Hong

    2017-01-01

    GitHub is a social collaborative coding platform on which software developers not only collaborate on codes but also share knowledge through blogs using GitHub Pages. In this article, we analyze the blogging behavior of software developers on GitHub Pages. The results show that both the commit number and the inter-event time of two consecutive blogging actions follow heavy-tailed distribution. We further observe a significant variety of activity among individual developers, and a strongly positive correlation between the activity and the power-law exponent of the inter-event time distribution. We also find a difference between the user behaviors of GitHub Pages and other online systems which is driven by the diversity of users and length of contents. In addition, our result shows an obvious difference between the majority of developers and elite developers in their burstiness property.

  8. Sci-Hub: What Librarians Should Know and Do about Article Piracy.

    Science.gov (United States)

    Hoy, Matthew B

    2017-01-01

    The high cost of journal articles has driven many researchers to turn to a new way of getting access: "pirate" article sites. Sci-Hub, the largest and best known of these sites, currently offers instant access to more than 58 million journal articles. Users attracted by the ease of use and breadth of the collection may not realize that these articles are often obtained using stolen credentials and downloading them may be illegal. This article will briefly describe Sci-Hub and how it works, the legal and ethical issues it raises, and the problems it may cause for librarians. Librarians should be aware of Sci-Hub and the ways it may change their patrons' expectations. They should also understand the risks Sci-Hub can pose to their patrons and their institutions.

  9. A Dynamic Calibration Method for Experimental and Analytical Hub Load Comparison

    Science.gov (United States)

    2017-03-01

    ARL-RP-0592 ● Mar 2017 US Army Research Laboratory A Dynamic Calibration Method for Experimental and Analytical Hub Load Comparison by Robert P... A Dynamic Calibration Method for Experimental and Analytical Hub Load Comparison by Robert P Thornburgh, Andrew R Kreshock, and Matthew L...other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a

  10. A novel virtual hub approach for multisource downstream service integration

    Science.gov (United States)

    Previtali, Mattia; Cuca, Branka; Barazzetti, Luigi

    2016-08-01

    A large development of downstream services is expected to be stimulated starting from earth observations (EO) datasets acquired by Copernicus satellites. An important challenge connected with the availability of downstream services is the possibility for their integration in order to create innovative applications with added values for users of different categories level. At the moment, the world of geo-information (GI) is extremely heterogeneous in terms of standards and formats used, thus preventing a facilitated access and integration of downstream services. Indeed, different users and data providers have also different requirements in terms of communication protocols and technology advancement. In recent years, many important programs and initiatives have tried to address this issue even on trans-regional and international level (e.g. INSPIRE Directive, GEOSS, Eye on Earth and SEIS). However, a lack of interoperability between systems and services still exists. In order to facilitate the interaction between different downstream services, a new architectural approach (developed within the European project ENERGIC OD) is proposed in this paper. The brokering-oriented architecture introduces a new mediation layer (the Virtual Hub) which works as an intermediary to bridge the gaps linked to interoperability issues. This intermediation layer de-couples the server and the client allowing a facilitated access to multiple downstream services and also Open Data provided by national and local SDIs. In particular, in this paper an application is presented integrating four services on the topic of agriculture: (i) the service given by Space4Agri (providing services based on MODIS and Landsat data); (ii) Gicarus Lab (providing sample services based on Landsat datasets) and (iii) FRESHMON (providing sample services for water quality) and services from a several regional SDIs.

  11. NGC 281: A Bustling Hub of Star Formation

    Science.gov (United States)

    2005-01-01

    NGC 281 is a bustling hub of star formation about 10,000 light years away. This composite image of optical and X-ray emission includes regions where new stars are forming and older regions containing stars about 3 million years old. The optical data (seen in red, orange, and yellow) show a small open cluster of stars, large lanes of obscuring gas and dust, and dense knots where stars may still be forming. The X-ray data (purple), based on a Chandra observation lasting more than a day, shows a different view. More than 300 individual X-ray sources are seen, most of them associated with IC 1590, the central cluster. The edge-on aspect of NGC 281 allows scientists to study the effects of powerful X-rays on the gas in the region, the raw material for star formation. A second group of X-ray sources is seen on either side of a dense molecular cloud, known as NGC 281 West, a cool cloud of dust grains and gas, much of which is in the form of molecules. The bulk of the sources around the molecular cloud are coincident with emission from polycyclic aromatic hydrocarbons, a family of organic molecules containing carbon and hydrogen. There also appears to be cool diffuse gas associated with IC 1590 that extends toward NGC 281 West. The X-ray spectrum of this region shows that the gas is a few million degrees and contains significant amounts of magnesium, sulfur and silicon. The presence of these elements suggests that supernova recently went off in that area.

  12. Disrupted nodal and hub organization account for brain network abnormalities in Parkinson’s disease

    Directory of Open Access Journals (Sweden)

    Yuko Koshimori

    2016-11-01

    Full Text Available The recent application of graph theory to brain networks promises to shed light on complex diseases such as Parkinson’s disease. This study aimed to investigate functional changes in sensorimotor and cognitive networks in parkinsonian patients, with a focus on inter- and intra-connectivity organization in the disease-associated nodal and hub regions using the graph theoretical analyses. Resting-state functional MRI data of a total of 65 participants, including 23 healthy controls and 42 patients, were investigated in 120 nodes for local efficiency, betweenness centrality, and degree. Hub regions were identified in the healthy control and patient groups. We found nodal and hub changes in patients compared with healthy controls, including the right pre-supplementary motor area, left anterior insula, bilateral mid-insula, bilateral dorsolateral prefrontal cortex, and right caudate nucleus. In general, nodal regions within the sensorimotor network (i.e. right pre-supplementary motor area and right mid-insula displayed weakened connectivity, with the former node associated with more severe bradykinesia, and impaired integration with default mode network regions. The left mid-insula also lost its hub properties in patients. Within the executive networks, the left anterior insular cortex lost its hub properties in patients, while a new hub region was identified in the right caudate nucleus, paralleled by an increased level of inter- and intra-connectivity in the bilateral dorsolateral prefrontal cortex possibly representing compensatory mechanisms. These findings highlight the diffuse changes in nodal organization and regional hub disruption accounting for the distributed abnormalities across brain networks and the clinical manifestations of Parkinson’s disease.

  13. Measuring Improvement when Using HUB Formats to Implement Floating-Point Systems under Round-to-Nearest

    OpenAIRE

    Hormigo, Javier; Julio, Villalba

    2016-01-01

    This paper analyzes the benefits of using HUB formats to implement floating-point arithmetic under round-tonearest mode from a quantitative point of view. Using HUB formats to represent numbers allows the removal of the rounding logic of arithmetic units, including sticky-bit computation. This is shown for floating-point adders, multipliers, and converters. Experimental analysis demonstrates that HUB formats and the corresponding arithmetic units maintain the same accurac...

  14. The application of design criteria for locating a hub configured supply chain for a restaurant cluster in the Stellenbosch area

    Directory of Open Access Journals (Sweden)

    Claudia B. Struwig

    2013-05-01

    Full Text Available Restaurants, in general, utilise numerous suppliers. Normally they deliver on different days in the week and at different times during the day, logistically not an optimum approach. Not only does the current practice cause frequent interruptions, but by segregating the food supply chain unnecessary traffic is generated. This article investigated the need for developing a third party supplier hub, the best positioning of that hub and the most economical routes to the customers. With the aim of providing non-franchised restaurants with the necessary leverage to become market leaders, the hub is planned to only service the restaurants within the vicinity of the Stellenbosch area. In such a hub-configured supply chain, the suppliers would be delivering to the proposed hub, from where once-off deliveries to all the restaurants may be made on days and/or times determined by them. In order to investigate the benefits of providing such a hub structure, a systematic implementation approach was used. The first step was to do market research in order to establish the need for such a hub. That is, the viability of the hub from a restaurant’s perspective was established. The next step entailed the investigation of the design criteria needed in determining a favourable hub location. Four possible hub locations were identified. The Clark and Wright’s savings algorithm was then used to determine the optimal hub location and the feasibility of the results was verified with the aid of a global positioning system (GPS device. The last steps followed involved the determination of an effective hub floor plan that may be utilised, possible products that can be supplied to the restaurants and the necessary assets needed to provide the hub’s service. Finally, by incorporating all these facets, a cost analysis was done to determine the hub’s profitability.

  15. Understanding farmers' preferences for artificial insemination services provided through dairy hubs.

    Science.gov (United States)

    Omondi, I A; Zander, K K; Bauer, S; Baltenweck, I

    2017-04-01

    Africa has a shortage of animal products but increasing demand because of population growth, urbanisation and changing consumer patterns. Attempts to boost livestock production through the use of breeding technologies such as artificial insemination (AI) have been failing in many countries because costs have escalated and success rates have been relatively low. One example is Kenya, a country with a relatively large number of cows and a dairy industry model relevant to neighbouring countries. There, an innovative dairy marketing approach (farmer-owned collective marketing systems called dairy hubs) has been implemented to enhance access to dairy markets and dairy-related services, including breeding services such as AI. So far, the rate of participation in these dairy hubs has been slow and mixed. In order to understand this phenomenon better and to inform dairy-related development activities by the Kenyan government, we investigated which characteristics of AI services, offered through the dairy hubs, farmers prefer. To do so, we applied a choice experiment (CE), a non-market valuation technique, which allowed us to identify farmers' preferences for desired characteristics should more dairy hubs be installed in the future. This is the first study to use a CE to evaluate breeding services in Kenya and the results can complement findings of studies of breeding objectives and selection criteria. The results of the CE reveal that dairy farmers prefer to have AI services offered rather than having no service. Farmers prefer AI services to be available at dairy hubs rather than provided by private agents not affiliated to the hubs, to have follow-up services for pregnancy detections, and to use sexed semen rather than conventional semen. Farmers would further like some flexibility in payment systems which include input credit, and are willing to share the costs of any AI repeats that may need to occur. These results provide evidence of a positive attitude to AI services

  16. TYPE PROJECTS HUB - AN INTERNATIONAL MODEL OF DEVELOPMENT OF THE ENTREPRENEURIAL ENVIRONMENT

    Directory of Open Access Journals (Sweden)

    Rozalia Nistor

    2014-06-01

    Full Text Available Impact Hub is a global network of local spaces and communities designed to facilitate sustainable impact through collaboration. Local Impact Hubs are autonomous companies that offer co-working spaces, programming, events platforms, and communities of individuals and organizations with ideas to build a better world. Hub was established in 2005 in London with the aim of creating a space dedicated to inspire, connect and enable people to achieve a sustainable entrepreneurial idea. The idea was simple: There are a lot of people with good ideas for a "better world". What seem to be missing are places to help these people to move from intent to action and to find like-minded for a greater impact. In Romania about four years ago, first opened in Bucharest office space hubs in Romania (for entrepreneurs in technology and business where teams from different companies could collaborate. The idea to open a hub in Bucharest focused on social innovation and entrepreneurship appeared some time ago in the context in which part of the team now has worked since 2010 at the initiation and growth of a community to support social entrepreneurship. In all this diversity, there is a common mission: “we can create if we put all our innovation capacity in the common goal to create a positive impact through our work?”

  17. nanoHUB.org: Experiences and Challenges in Software Sustainability for a Large Scientific Community

    Directory of Open Access Journals (Sweden)

    Lynn Zentner

    2014-07-01

    Full Text Available The science gateway nanoHUB.org, funded by the National Science Foundation (NSF, serves a large scientific community dedicated to research and education in nanotechnology with community-contributed simulation codes as well as a vast repository of other materials such as recorded presentations, teaching materials, and workshops and courses. Nearly 330,000 users annually access over 4400 items of content on nanoHUB, including 343 simulation tools. Arguably the largest nanotechnology facility in the world, nanoHUB has led the way not only in providing open access to scientific code in the nanotechnology community, but also in lowering barriers to the use of that code, by providing a platform where developers are able to easily and quickly deploy code written in a variety of languages with user-friendly graphical user interfaces and where users can run the latest versions of codes transparently on the grid or other powerful resources without ever having to download or update code. Being a leader in open access code deployment provides nanoHUB with opportunities and challenges as it meets the current and future needs of its community. This paper discusses the experiences of nanoHUB in addressing and adapting to the changing landscape of scientific software in ways that best serve its community and meet the needs of the largest portion of its user base.

  18. Forecasting Beijing Transportation Hub Areas’s Pedestrian Flow Using Modular Neural Network

    Directory of Open Access Journals (Sweden)

    Shuwei Wang

    2015-01-01

    Full Text Available Along with the increasing proportion of urban public transportation trip, pedestrian flow in transportation hub areas increased. For effectively improving the emergency handling ability of related management apartments and preventing the incident of pedestrian congestion, this paper studied the method of pedestrian flow forecast in Beijing transportation hub areas. Firstly, 34 typical sidewalks in Beijing transportation hub areas were surveyed to obtain 2200 valid data. Secondly, correlation analysis was used to analyze the relationship between pedestrian flow and its influential factors. 11 significant influential factors were extracted. Thirdly, forecasting model was established with modular neural network. The surveyed pedestrian flow sample was fuzzy clustered according to the regional land use where the transportation hub existed. Then, membership function based on the distance measure was constructed. Through fuzzy discrimination, online selection for the subnetwork of the information can be achieved. Consequently, the self-adaptation of the neural network on information processing was improved. Finally, this paper tested the pedestrian flow sample of a transportation hub in Beijing. It was concluded that the accuracy of pedestrian flow forecasting model using modular neural network was higher than other neural network models. There was also improvement in the adaptability to environment.

  19. The influence of hubs in the structure of a neuronal network during an epileptic seizure

    Science.gov (United States)

    Rodrigues, Abner Cardoso; Cerdeira, Hilda A.; Machado, Birajara Soares

    2016-02-01

    In this work, we propose changes in the structure of a neuronal network with the intention to provoke strong synchronization to simulate episodes of epileptic seizure. Starting with a network of Izhikevich neurons we slowly increase the number of connections in selected nodes in a controlled way, to produce (or not) hubs. We study how these structures alter the synchronization on the spike firings interval, on individual neurons as well as on mean values, as a function of the concentration of connections for random and non-random (hubs) distribution. We also analyze how the post-ictal signal varies for the different distributions. We conclude that a network with hubs is more appropriate to represent an epileptic state.

  20. Identifying overlapping communities as well as hubs and outliers via nonnegative matrix factorization.

    Science.gov (United States)

    Cao, Xiaochun; Wang, Xiao; Jin, Di; Cao, Yixin; He, Dongxiao

    2013-10-21

    Community detection is important for understanding networks. Previous studies observed that communities are not necessarily disjoint and might overlap. It is also agreed that some outlier vertices participate in no community, and some hubs in a community might take more important roles than others. Each of these facts has been independently addressed in previous work. But there is no algorithm, to our knowledge, that can identify these three structures altogether. To overcome this limitation, we propose a novel model where vertices are measured by their centrality in communities, and define the identification of overlapping communities, hubs, and outliers as an optimization problem, calculated by nonnegative matrix factorization. We test this method on various real networks, and compare it with several competing algorithms. The experimental results not only demonstrate its ability of identifying overlapping communities, hubs, and outliers, but also validate its superior performance in terms of clustering quality.

  1. Synchronization and long-time memory in neural networks with inhibitory hubs and synaptic plasticity

    Science.gov (United States)

    Bertolotti, Elena; Burioni, Raffaella; di Volo, Matteo; Vezzani, Alessandro

    2017-01-01

    We investigate the dynamical role of inhibitory and highly connected nodes (hub) in synchronization and input processing of leaky-integrate-and-fire neural networks with short term synaptic plasticity. We take advantage of a heterogeneous mean-field approximation to encode the role of network structure and we tune the fraction of inhibitory neurons fI and their connectivity level to investigate the cooperation between hub features and inhibition. We show that, depending on fI, highly connected inhibitory nodes strongly drive the synchronization properties of the overall network through dynamical transitions from synchronous to asynchronous regimes. Furthermore, a metastable regime with long memory of external inputs emerges for a specific fraction of hub inhibitory neurons, underlining the role of inhibition and connectivity also for input processing in neural networks.

  2. Nonlinear Dynamic Analysis of Functionally Graded Timoshenko Beam fixed to a Rotating Hub

    Science.gov (United States)

    Panigrahi, B.; Pohit, G.

    2016-08-01

    The present work accounts centrifugal stiffening effect on the nonlinear vibration response of an FGM Timoshenko beam. Analysis is carried out for a cantilever beam fixed with a rotating hub. Material is assumed to have a gradation relation along the depth of the beam. Centrifugal force and axial displacement raised due to the rotating hub is incorporated in the strain energy equations. Subsequent to this, an iterative technique is employed to obtain amplitude dependent vibration response of a rotating Timoshenko beam while material follows a gradation relation along the beam depth. Main objective of the work is to obtain the effects of rotational speeds, hub radius, and different gradation relations on the linear as well as nonlinear frequencies and mode shapes.

  3. Effect of random and hub gene disruptions on environmental and mutational robustness in Escherichia coli

    Directory of Open Access Journals (Sweden)

    Schneider Dominique

    2006-09-01

    Full Text Available Background Genome-wide profiling has allowed the regulatory interaction networks of many organisms to be visualised and the pattern of connections between genes to be studied. These networks are non-random, following a power-law distribution with a small number of well-connected 'hubs' and many genes with only one or a few connections. Theoretical work predicts that power-law networks display several unique properties. One of the most biologically interesting of these is an intrinsic robustness to disturbance such that removal of a random gene will have little effect on network function. Conversely, targeted removal of a hub gene is expected to have a large effect. Results We compared the response of Escherichia coli to environmental and mutational stress following disruption of random or hub genes. We found that disruption of random genes had less effect on robustness to environmental stress than did the targeted disruption of hub genes. In contrast, random disruption strains were slightly less robust to the effect of mutational stress than were hub disruption strains. When we compared the effect of each disruption on environmental and mutational stress, we found a negative relationship, such that strains that were more environmentally robust tended to be less robust to mutational stress. Conclusion Our results demonstrate that mutant strains of E. coli respond differently to stress, depending on whether random or hub genes are disrupted. This difference indicates that the power-law distribution of regulatory interactions has biological significance, making random disruptions less deleterious to organisms facing environmental stress. That E. coli can reduce the effect of environmental stress without reducing the phenotypic effect of additional mutations, indicates that robustness and evolvability need not be antagonistic.

  4. Characterization of protein hubs by inferring interacting motifs from protein interactions.

    Directory of Open Access Journals (Sweden)

    Ramon Aragues

    2007-09-01

    Full Text Available The characterization of protein interactions is essential for understanding biological systems. While genome-scale methods are available for identifying interacting proteins, they do not pinpoint the interacting motifs (e.g., a domain, sequence segments, a binding site, or a set of residues. Here, we develop and apply a method for delineating the interacting motifs of hub proteins (i.e., highly connected proteins. The method relies on the observation that proteins with common interaction partners tend to interact with these partners through a common interacting motif. The sole input for the method are binary protein interactions; neither sequence nor structure information is needed. The approach is evaluated by comparing the inferred interacting motifs with domain families defined for 368 proteins in the Structural Classification of Proteins (SCOP. The positive predictive value of the method for detecting proteins with common SCOP families is 75% at sensitivity of 10%. Most of the inferred interacting motifs were significantly associated with sequence patterns, which could be responsible for the common interactions. We find that yeast hubs with multiple interacting motifs are more likely to be essential than hubs with one or two interacting motifs, thus rationalizing the previously observed correlation between essentiality and the number of interacting partners of a protein. We also find that yeast hubs with multiple interacting motifs evolve slower than the average protein, contrary to the hubs with one or two interacting motifs. The proposed method will help us discover unknown interacting motifs and provide biological insights about protein hubs and their roles in interaction networks.

  5. Hub vortex instability and wake dynamics in axial flow wind turbines

    Science.gov (United States)

    Foti, Daniel; Howard, Kevin; Yang, Xiaolei; Guala, Michele; Sotiropoulos, Fotis

    2014-11-01

    The near wake region of an axial flow wind turbine has two distinct shear layers: an outer tip vortex shear layer, which rotates in the same direction as the rotor, and an inner counter-rotating hub vortex shear layer. Recent simulations (Kang et al., J. Fluid Mech. 744, 376 (2014)), corroborated with experiments (Chamorro et al., J. Fluid Mech. 716, 658 (2013)), showed that the hub vortex can undergo spiral vortex breakdown immediately downstream of the turbine. The precessing hub vortex core intercepts and interacts with the tip vortex shear layer causing the large-scale wake meandering motions in the far wake to intensify. These results were obtained for an axial flow hydrokinetic turbine in a turbulent open channel flow. Here we integrate high-resolution LES with experiments to show that a hub vortex instability also occurs in the near wake of a wind turbine in a wind tunnel. We show that the interactions of the hub vortex with the outer flow have significant effects on the wake meandering amplitude and frequency. Our results reinforce the conclusions of Kang et al. (2014) that the hub vortex must be included in wake models to simulate wake interactions at the power plant scale and optimize turbine siting for realistic terrain and wind conditions. This work was supported by DOE (DE-EE0002980, DE-EE0005482 and DE-AC04-94AL85000), the NSF (IIP-1318201), the IREE early career award (UMN) and NSF CAREER: Geophysical Flow Control (CBET-1351303). Computational resources were provided by MSI.

  6. Hub vortex instability within wind turbine wakes: Effects of wind turbulence, loading conditions, and blade aerodynamics

    Science.gov (United States)

    Ashton, Ryan; Viola, Francesco; Camarri, Simone; Gallaire, Francois; Iungo, Giacomo Valerio

    2016-11-01

    The near wake of wind turbines is characterized by the presence of the hub vortex, which is a coherent vorticity structure generated from the interaction between the root vortices and the boundary layer evolving over the turbine nacelle. By moving downstream, the hub vortex undergoes an instability with growth rate, azimuthal and axial wavenumbers determined by the characteristics of the incoming wind and turbine aerodynamics. Thus, a large variability of the hub vortex instability is expected for wind energy applications with consequent effects on wake downstream evolution, wake interactions within a wind farm, power production, and fatigue loads on turbines invested by wakes generated upstream. In order to predict characteristics of the hub vortex instability for different operating conditions, linear stability analysis is carried out by considering different statistics of the incoming wind turbulence, thrust coefficient, tip speed ratio, and blade lift distribution of a wind turbine. Axial and azimuthal wake velocity fields are modeled through Carton-McWilliams velocity profiles by mimicking the presence of the hub vortex, helicoidal tip vortices, and matching the wind turbine thrust coefficient predicted through the actuator disk model. The linear stability analysis shows that hub vortex instability is strongly affected by the wind turbine loading conditions, and specifically it is promoted by a larger thrust coefficient. A higher load of the wind turbines produces an enhanced axial velocity deficit and, in turn, higher shear in the radial direction of the streamwise velocity. The axial velocity shear within the turbine wake is also the main physical mechanism promoting the hub vortex instability when varying the lift distribution over the blade span for a specific loading condition. Cases with a larger velocity deficit in proximity of the wake center and less aerodynamic load towards the blade tip result to be more unstable. Moreover, wake swirl promotes hub

  7. Japanese Forwarders’ Local Import Hub in Asia: 3PL Power and Environmental Improvement

    Directory of Open Access Journals (Sweden)

    Kunio MIYASHITA

    2015-09-01

    Full Text Available The purpose of this paper is to demonstrate by an econometric method which countries or regions in Asia are superior import hubs for Japan based on two axes, the third party logistics (3PL business power of Japanese local forwarders and the logistical environment catch-up speed of these countries. According to the estimated results, this simple model can explain the structural changes in China's logistics based on its WTO accession and can develop Japanese forwarders’ stable import hub ranking by suggesting total optimization in the East Asian NIES (newly industrial economies and the ASEAN (Association of Southeast Asian Countries districts by Japanese forwarders.

  8. Single wheel hub motor failures and their impact on vehicle and driver behaviour

    Science.gov (United States)

    Wanner, Daniel; Kreußlein, Maria; Augusto, Bruno; Drugge, Lars; Stensson Trigell, Annika

    2016-10-01

    This research work studies the impact of single wheel hub motor failures on the dynamic behaviour of electric vehicles and the corresponding driver reactions. An experimental study in a moving-base driving simulator is conducted to analyse the influence of single wheel hub motor failures for motorway speeds. Driver reaction times are derived from the measured data and discussed in their experimental context. The failure is rated objectively on the dynamic behaviour of the vehicle and compared to the subjective evaluation. Findings indicate that critical traffic situations impairing traffic safety can occur for motorway speeds. Clear counteractions by the drivers had to be taken.

  9. Transfer Scheme Evaluation Model for a Transportation Hub based on Vectorial Angle Cosine

    Directory of Open Access Journals (Sweden)

    Li-Ya Yao

    2014-07-01

    Full Text Available As the most important node in public transport network, efficiency of a transport hub determines the entire efficiency of the whole transport network. In order to put forward effective transfer schemes, a comprehensive evaluation index system of urban transport hubs’ transfer efficiency was built, evaluation indexes were quantified, and an evaluation model of a multi-objective decision hub transfer scheme was established based on vectorial angle cosine. Qualitative and quantitative analysis on factors affecting transfer efficiency is conducted, which discusses the passenger satisfaction, transfer coordination, transfer efficiency, smoothness, economy, etc. Thus, a new solution to transfer scheme utilization was proposed.

  10. Virtual Campus Hub: A single sign-on system for cross-border collaboration

    DEFF Research Database (Denmark)

    Badger, Merete; Vercoulen, F.; Monaco, L.

    2013-01-01

    the applications used there. The objective of Virtual Campus Hub is to use state-of-the-art European e-Infrastructures (Géant) in combination with federated authentication to establish a single sign-on system between universities. A pilot environment, which links applications from the four partner universities...... to European e-Infrastructures relies upon the National Research and Education Networks (NRENs) which are not geared towards commercial enterprises at present. A range of applications for online teaching and collaboration has been developed as part of the Virtual Campus Hub project. These include remote...

  11. Hub-enhanced noise-sustained synchronization of an externally forced FitzHugh-Nagumo ring

    Science.gov (United States)

    Sánchez, Alejandro D.; Izús, Gonzalo G.; dell'Erba, Matías G.; Deza, Roberto R.

    2017-02-01

    A ring of FitzHugh-Nagumo units with antiphase coupling between their activator fields and submitted to a adiabatic harmonic subthreshold signal, is in turn globally coupled in electrical mode with the activator field of a hub. Noise sustained synchronization of neural activity with the signal is numerically observed, and theoretically characterized. The different dynamical regimes are elucidated using the concept of nonequilibrium potential, and the hub is found to promote network synchronization. The minimum noise intensities triggering the activation and synchronization processes are estimated in the framework of a three-neuron model.

  12. The Design Pattern: Hub of Enterprise Application Integration%一个企业应用集成的设计模式:Hub

    Institute of Scientific and Technical Information of China (English)

    董云卫; 李伟宏; 郝克刚

    2003-01-01

    The Enterprise Application Integration (EAI) is a challenge of modern enterprise. How much effect of information system in enterprise business implement process that depends on the degree of inner function and information integration of formation system. The choice of EAI methods not only affects the investment of constructing information system and protecting /using old system, but also determines the efficiency of new system. This paper presents a design pattern, named Hub method, from the view of application integration, which adopts the idea in heterogeneous circumstance focusing on interface encapsulating about controlling information exchange and workflow handling. It also gives an implement method and a framework of the Hub in this paper, which is applied on business process management. And a good performance is achieved in controlling information exchange and workflow handling among enterprise applications. It not only improves system integration capability, stich as expansibility, flexibility, and opening through the method of the Hub, but also takes a great advance in soft reuse during software designing and implementing.

  13. 76 FR 10328 - Grant of Authority for Subzone Status; Vestas Nacelles America, Inc. (Wind Turbine Nacelles, Hubs...

    Science.gov (United States)

    2011-02-24

    ... manufacturing and warehousing of wind turbine nacelles, hubs, blades and towers at the Vestas Nacelles America... Foreign-Trade Zones Board Grant of Authority for Subzone Status; Vestas Nacelles America, Inc. (Wind Turbine Nacelles, Hubs, Blades and Towers), Brighton, Denver, Pueblo, and Windsor, CO Pursuant to...

  14. 75 FR 76003 - Tricor Ten Section Hub LLC; Notice of Availability of the Environmental Assessment for the...

    Science.gov (United States)

    2010-12-07

    ... Energy Regulatory Commission Tricor Ten Section Hub LLC; Notice of Availability of the Environmental Assessment for the Proposed Ten Section Gas Storage Project November 29, 2010. The staff of the Federal... Ten Section Gas Storage Project, in Kern County, California, proposed by Tricor Ten Section Hub...

  15. USDA Midwest and Northern Forests Regional Climate Hub: Assessment of climate change vulnerability and adaptation and mitigation strategies

    Science.gov (United States)

    The Midwest Regional Climate Hub covers the States of Illinois, Indiana, Iowa, Michigan, Minnesota, Missouri, Ohio, and Wisconsin and represents one of the most extensive and intensive agricultural systems in the world. The Northern Forests Climate Sub Hub shares this footprint and represents people...

  16. Role of governance in creating a commodity hub: A comparative analysis

    Directory of Open Access Journals (Sweden)

    M.P. Haris

    2016-10-01

    Full Text Available The body of work on natural gas hubs has been expanding rapidly in recent years, with most of the current work examining the creation of gas hubs focusing on either the European experience or the North American experience. In this paper, we adopt a different perspective and place the focus on experience of hub building from other international commodities. We analyse three commodities - crude oil, iron ore and coal, and draw experience on the role of governance in development of hub based prices. In particular, we propose that the role of governance is different at different stages of the pricing transition to market based pricing. Governance could play an important role at the initial stage, building the relevant soft and physical infrastructure which facilitates the reaping of first mover advantage. As the market develops, private sector players may prefer less involvement of governance, which may distort markets. With market stabilization, governance should be focused on maintaining stable rules and regulation for private sector development, as well as monitoring for further changes in global trends. To facilitate the building of a benchmark price, the public sector should adopt a long-term and overarching view on industry growth.

  17. Hub-and-Spoke or else? Free trade agreements in the 'enlarged' European Union

    Directory of Open Access Journals (Sweden)

    Roberta De Santis

    2005-12-01

    Full Text Available The object of this paper is to estimate if and how the Central European Free Trade Agreement (CEFTA and the Baltic Free Trade Agreement (BFTA exerted a significant impact on intra-European trade, effectively reducing the influence of the European Association Agreements (EAs in shaping the European trade structure as a hub-and-spoke system - with the EU15 being the hub and the CEECs the spoke. This paper analyses bilateral trade flows between eight CEECs and EU-23. We estimate a gravity equation using a system GMM dynamic panel data approach. Results support the assumptions that gravity forces and "persistence effects" matter. With respect to the effect of free trade agreements, evidence is found that Free trade agreements between CEECs matter: There is evidence that the presence of intra-periphery agreements helped expand intra-periphery trade and limited the emergence of a "hub-and-spoke" relationship between CEECs and EU. This results have important policy implications for the trade strategy of "future" EU members of the Southeastern European Countries as well as of the Southern Mediterranean Countries. According to the empirical results, these countries should move towards a regional free-trade area as exemplified by the CEFTA and the BFTA to avoid "hub-and-spoke" effects.

  18. Unveiling Exception Handling Bug Hazards in Android Based on GitHub and Google Code Issues

    NARCIS (Netherlands)

    Coelho, R.; Almeida, L.; Gousios, G.; Van Deursen, A.

    2015-01-01

    This paper reports on a study mining the exception stack traces included in 159,048 issues reported on Android projects hosted in GitHub (482 projects) and Google Code (157 projects). The goal of this study is to investigate whether stack trace information can reveal bug hazards related to exception

  19. Towards collaborative, intermodal hub networks. A case study in the fast moving consumer goods market

    NARCIS (Netherlands)

    Groothedde, B.; Ruijgrok, C.; Tavasszy, L.

    2005-01-01

    Collaborative hub networks can provide an answer to the need to decrease logistics cost and maintain logistics service levels by shifting consolidated flows to modes that are better suited for handling large volumes (rail, barge, coastal shipping), so economies of scale can be obtained. This necessi

  20. Hub and shroud fillets influence on the radial compressor stage efficiency

    Directory of Open Access Journals (Sweden)

    Syka Tomáš

    2015-01-01

    Full Text Available Article describes numerical simulations of an air flow in the radial compressor stage in the NUMECA CFD software. During the tasks evaluating the stepped and straight impeller seals and hub and shroud fillets influence on working characteristics and flow field was observed. Also the CFD results comparison with results from the empiric design tool and the measurement is described.

  1. An Optimization of the Hub-and-Spoke Distribution Network in United States European Command

    Science.gov (United States)

    2002-03-01

    9 Vehicle Routing Problem ......................................................................................... 11...system. These range from direct delivery to a fully developed hub-and-spoke system. These models all include some variation of the vehicle routing problem , facility...assets. Vehicle Routing Problem Vehicle Routing Problems (VRPs) are based on the classic Traveling Salesman Problem (TSP). The TSP is

  2. Positioning as Regional Hub of Higher Education: Changing Governance and Regulatory Reforms in Singapore and Malaysia

    Science.gov (United States)

    Mok, Ka Ho

    2008-01-01

    With strong intention to enhance the global competitiveness of their university systems, the Singapore and Malaysia governments have made attempts to develop their societies into regional hubs of education. Specifically, they have invited foreign universities to set up their campuses to offer academic programs or to establish private institutions…

  3. Positioning as Regional Hub of Higher Education: Changing Governance and Regulatory Reforms in Singapore and Malaysia

    Science.gov (United States)

    Mok, Ka Ho

    2008-01-01

    With strong intention to enhance the global competitiveness of their university systems, the Singapore and Malaysia governments have made attempts to develop their societies into regional hubs of education. Specifically, they have invited foreign universities to set up their campuses to offer academic programs or to establish private institutions…

  4. Evaluating Hub and Spoke models of practice learning in Scotland, UK: a multiple case study approach.

    Science.gov (United States)

    Roxburgh, Michelle; Conlon, Margaret; Banks, Debbie

    2012-10-01

    Most of UK students' practice learning experience is based on a rotational placement model which often leads to students lacking confidence and feeling anxious about the complexities of the care environment. To evaluate the impact of Hub and Spoke model(s) of clinical practice placement across geographically diverse locations, with a particular focus on enhancing the student practice learning experience. Multiple case study design. Comprised undergraduate student nurses from Adult, Learning Disability and Mental Health programmes from 3 Scottish Schools of Nursing. A mixed methods approach which included quantitative and qualitative date tools. All three Hub and Spoke models shared two broad findings: 1) In the three Hub and Spoke models detailed in this paper, there is a continuum of student led learning which supports the process with opportunities for individual students to be positively innovative and creative in their learning approaches. Depth of learning was achieved in two ways; a) the method in which Hub placements are organised, managed and structured and, b) the depth of empathy and sensitivity to the individual at the centre of the care. 2) Placement capacity is increased: The classification of placements is reviewed to produce broader categories, Engagement of mentors/enhanced student/mentor relationship. Practice Learning must be seen as an academic endeavour that promotes deep, meaningful, person-centred learning rather than superficial, compartmentalised placement-centred learning. Copyright © 2012 Elsevier Ltd. All rights reserved.

  5. Dynamic network participation of functional connectivity hubs assessed by resting-state fMRI

    Science.gov (United States)

    Schaefer, Alexander; Margulies, Daniel S.; Lohmann, Gabriele; Gorgolewski, Krzysztof J.; Smallwood, Jonathan; Kiebel, Stefan J.; Villringer, Arno

    2014-01-01

    Network studies of large-scale brain connectivity have demonstrated that highly connected areas, or “hubs,” are a key feature of human functional and structural brain organization. We use resting-state functional MRI data and connectivity clustering to identify multi-network hubs and show that while hubs can belong to multiple networks their degree of integration into these different networks varies dynamically over time. The extent of the network variation was related to the connectedness of the hub. In addition, we found that these network dynamics were inversely related to positive self-generated thoughts reported by individuals and were further decreased with older age. Moreover, the left caudate varied its degree of participation between a default mode subnetwork and a limbic network. This variation was predictive of individual differences in the reports of past-related thoughts. These results support an association between ongoing thought processes and network dynamics and offer a new approach to investigate the brain dynamics underlying mental experience. PMID:24860458

  6. Fleet deployment, network design and hub location of liner shipping companies

    DEFF Research Database (Denmark)

    Gelareh, Shahin; Pisinger, David

    2011-01-01

    A mixed integer linear programming formulation is proposed for the simultaneous design of network and fleet deployment of a deep-sea liner service provider. The underlying network design problem is based on a 4-index (5-index by considering capacity type) formulation of the hub location problem...

  7. Towards collaborative, intermodal hub networks. A case study in the fast moving consumer goods market

    NARCIS (Netherlands)

    Groothedde, B.; Ruijgrok, C.; Tavasszy, L.

    2005-01-01

    Collaborative hub networks can provide an answer to the need to decrease logistics cost and maintain logistics service levels by shifting consolidated flows to modes that are better suited for handling large volumes (rail, barge, coastal shipping), so economies of scale can be obtained. This

  8. Perceptions of Quality Life in Hamilton's Neighbourhood Hubs: A Qualitative Analysis

    Science.gov (United States)

    Eby, Jeanette; Kitchen, Peter; Williams, Allison

    2012-01-01

    This paper examines perceptions of quality of life in Hamilton, Ontario, Canada from the perspective of residents and key community stakeholders. A series of eight focus groups were conducted. Six sessions were held with residents of neighbourhood "hubs", areas characterized by high levels of poverty. The following themes were highlighted as…

  9. A note on hierarchical hubbing for a generalization of the VPN problem

    NARCIS (Netherlands)

    Olver, N.K.

    2014-01-01

    Robust network design refers to a class of optimization problems that occur when designing networks to efficiently handle variable demands. The notion of "hierarchical hubbing" was introduced (in the narrow context of a specific robust network design question), by Olver and Shepherd [2010]. Hierarch

  10. National Geothermal Data System Hub Deployment Timeline (Appendix E-1-d)

    Energy Technology Data Exchange (ETDEWEB)

    Caudill, Christy [Executive Office of the State of Arizona (Arizona Geological Survey)

    2015-12-20

    Excel spreadsheet describing activity, spending, and development for the four data hubs (Arizona Geoloical Survey, Kentucky Geological Survey, Illinois Geological Survey, and Nevada Bureau of Mines and Geology) serving data for the National Geothermal Data System under the State Contributions to the National Geothermal Data System Project.

  11. Brief Report: The Negev Hospital-University-Based (HUB) Autism Database

    Science.gov (United States)

    Meiri, Gal; Dinstein, Ilan; Michaelowski, Analya; Flusser, Hagit; Ilan, Michal; Faroy, Michal; Bar-Sinai, Asif; Manelis, Liora; Stolowicz, Dana; Yosef, Lili Lea; Davidovitch, Nadav; Golan, Hava; Arbelle, Shosh; Menashe, Idan

    2017-01-01

    Elucidating the heterogeneous etiologies of autism will require investment in comprehensive longitudinal data acquisition from large community based cohorts. With this in mind, we have established a hospital-university-based (HUB) database of autism which incorporates prospective and retrospective data from a large and ethnically diverse…

  12. Perceptions of Quality Life in Hamilton's Neighbourhood Hubs: A Qualitative Analysis

    Science.gov (United States)

    Eby, Jeanette; Kitchen, Peter; Williams, Allison

    2012-01-01

    This paper examines perceptions of quality of life in Hamilton, Ontario, Canada from the perspective of residents and key community stakeholders. A series of eight focus groups were conducted. Six sessions were held with residents of neighbourhood "hubs", areas characterized by high levels of poverty. The following themes were…

  13. Fleet deployment, network design and hub location of liner shipping companies

    DEFF Research Database (Denmark)

    Gelareh, Shahin; Pisinger, David

    2011-01-01

    A mixed integer linear programming formulation is proposed for the simultaneous design of network and fleet deployment of a deep-sea liner service provider. The underlying network design problem is based on a 4-index (5-index by considering capacity type) formulation of the hub location problem...

  14. Dubai, Aiming to Be an Academic Hub, Strikes a Deal with Michigan State

    Science.gov (United States)

    Krieger, Zvika

    2007-01-01

    Dubai has long competed with its wealthy Persian Gulf neighbors to become a regional hub of higher education. Yet its Knowledge Village, a collection of nearly 20 foreign-university campuses and local educational institutes, has been overshadowed by Qatar's Education City, which is home to the branch campuses of a number of high-profile American…

  15. PERSEUS-HUB: Interactive and Collective Exploration of Large-Scale Graphs

    Directory of Open Access Journals (Sweden)

    Di Jin

    2017-07-01

    Full Text Available Graphs emerge naturally in many domains, such as social science, neuroscience, transportation engineering, and more. In many cases, such graphs have millions or billions of nodes and edges, and their sizes increase daily at a fast pace. How can researchers from various domains explore large graphs interactively and efficiently to find out what is ‘important’? How can multiple researchers explore a new graph dataset collectively and “help” each other with their findings? In this article, we present Perseus-Hub, a large-scale graph mining tool that computes a set of graph properties in a distributed manner, performs ensemble, multi-view anomaly detection to highlight regions that are worth investigating, and provides users with uncluttered visualization and easy interaction with complex graph statistics. Perseus-Hub uses a Spark cluster to calculate various statistics of large-scale graphs efficiently, and aggregates the results in a summary on the master node to support interactive user exploration. In Perseus-Hub, the visualized distributions of graph statistics provide preliminary analysis to understand a graph. To perform a deeper analysis, users with little prior knowledge can leverage patterns (e.g., spikes in the power-law degree distribution marked by other users or experts. Moreover, Perseus-Hub guides users to regions of interest by highlighting anomalous nodes and helps users establish a more comprehensive understanding about the graph at hand. We demonstrate our system through the case study on real, large-scale networks.

  16. Unveiling Exception Handling Bug Hazards in Android Based on GitHub and Google Code Issues

    NARCIS (Netherlands)

    Coelho, R.; Almeida, L.; Gousios, G.; Van Deursen, A.

    2015-01-01

    This paper reports on a study mining the exception stack traces included in 159,048 issues reported on Android projects hosted in GitHub (482 projects) and Google Code (157 projects). The goal of this study is to investigate whether stack trace information can reveal bug hazards related to exception

  17. Nonlinear dynamics and synchronisation of pendula attached to a rotating hub

    Science.gov (United States)

    Warminski, J.; Szmit, Z.; Latalski, J.

    2014-04-01

    A model of a nonlinear system composed of a hub with attached two pendula rotating in a horizontal plane is studied in the paper. Each single pendulum, treated as a stiff and massless rod with a lumped mass, is connected to the hub by a flapping hinge. Nonlinear stiffness and viscous damping of the hinge is taken into consideration. The system is excited by an external torque generated by a DC motor which is considered as an ideal system with torque given by a harmonic function. For small oscillations the problem is linearised and then solved analytically. An influence of the structural parameters like mass of the hub and pendula length on natural end excited vibrations is presented. Large oscillations are studied by a continuation technique, directly from the original Ordinary Differential Equations of motion (ODE). The complete synchronisation, phase synchronisation, bifurcations and transition through resonances are analysed considering the influence of the mass of the hub. The existence of chaotic oscillations of the system and paths leading to chaos are demonstrated as well.

  18. Strategic analysis on establishing a natural gas trading hub in China

    Directory of Open Access Journals (Sweden)

    Xiaoguang Tong

    2014-12-01

    Full Text Available Since 2010, the LNG importing price premium in the Asia–Pacific markets has become increasingly high, generating great effects on the economic development in China. In addition, the natural gas dependence degree is expanding continuously, making it extremely urgent to establish a natural gas trading hub in China, with the aim to ensure national energy security, to gain the pricing power, and to build the regional benchmark prices. Through a comparative analysis of internal strength/weakness and external competitiveness, we concluded that with intensively-issued supporting policies on the natural gas sector, the initiation of spot and futures markets, the rapid growth of gas production and highly-improved infrastructures, as well as Shanghai's advantageous location, China has more advantages in establishing an Asian Natural Gas Trading Hub than other counties like Singapore, Japan and Malaysia. Moreover, based on the SWOT (strength, weakness, opportunity and threat and the marketization process analysis, the following strategies were presented: to impel the establishment of a natural gas trading hub depending on the gas supply condition, to follow the policies to complete the gas storage system, to form regional communities by taking comparative advantages, and to reinforce the marketization reform and regulation system establishment with foreign experiences for reference. This study rationalized the necessity and practicality of establishing a natural gas trading hub in China and will help China make a proper decision and find a periodical strategic path in this sector.

  19. Altered connectivity pattern of hubs in default-mode network with Alzheimer's disease: an Granger causality modeling approach.

    Directory of Open Access Journals (Sweden)

    Xiaoyan Miao

    Full Text Available BACKGROUND: Evidences from normal subjects suggest that the default-mode network (DMN has posterior cingulate cortex (PCC, medial prefrontal cortex (MPFC and inferior parietal cortex (IPC as its hubs; meanwhile, these DMN nodes are often found to be abnormally recruited in Alzheimer's disease (AD patients. The issues on how these hubs interact to each other, with the rest nodes of the DMN and the altered pattern of hubs with respect to AD, are still on going discussion for eventual final clarification. PRINCIPAL FINDINGS: To address these issues, we investigated the causal influences between any pair of nodes within the DMN using Granger causality analysis and graph-theoretic methods on resting-state fMRI data of 12 young subjects, 16 old normal controls and 15 AD patients respectively. We found that: (1 PCC/MPFC/IPC, especially the PCC, showed the widest and distinctive causal effects on the DMN dynamics in young group; (2 the pattern of DMN hubs was abnormal in AD patients compared to old control: MPFC and IPC had obvious causal interaction disruption with other nodes; the PCC showed outstanding performance for it was the only region having causal relation with all other nodes significantly; (3 the altered relation between hubs and other DMN nodes held potential as a noninvasive biomarker of AD. CONCLUSIONS: Our study, to the best of our knowledge, is the first to support the hub configuration of the DMN from the perspective of causal relationship, and reveal abnormal pattern of the DMN hubs in AD. Findings from young subjects provide additional evidence for the role of PCC/MPFC/IPC acting as hubs in the DMN. Compared to old control, MPFC and IPC lost their roles as hubs owing to the obvious causal interaction disruption, and PCC was preserved as the only hub showing significant causal relations with all other nodes.

  20. Coffee Shops, Classrooms and Conversations: public engagement and outreach in a large interdisciplinary research Hub

    Science.gov (United States)

    Holden, Jennifer A.

    2014-05-01

    Public engagement and outreach activities are increasingly using specialist staff for co-ordination, training and support for researchers, they are also becoming expected for large investments. Here, the experience of public engagement and outreach a large, interdisciplinary Research Hub is described. dot.rural, based at the University of Aberdeen UK, is a £11.8 million Research Councils UK Rural Digital Economy Hub, funded as part of the RCUK Digital Economy Theme (2009-2015). Digital Economy research aims to realise the transformational impact of digital technologies on aspects of the environment, community life, cultural experiences, future society, and the economy. The dot.rural Hub involves 92 researchers from 12 different disciplines, including Geography, Hydrology and Ecology. Public Engagement and Outreach is embedded in the dot.rural Digital Economy Hub via an Outreach Officer. Alongside this position, public engagement and outreach activities are compulsory part of PhD student contracts. Public Engagement and Outreach activities at the dot.rural Hub involve individuals and groups in both formal and informal settings organised by dot.rural and other organisations. Activities in the realms of Education, Public Engagement, Traditional and Social Media are determined by a set of Underlying Principles designed for the Hub by the Outreach Officer. The underlying Engagement and Outreach principles match funding agency requirements and expectations alongside researcher demands and the user-led nature of Digital Economy Research. All activities include researchers alongside the Outreach Officer are research informed and embedded into specific projects that form the Hub. Successful public engagement activities have included participation in Café Scientifique series, workshops in primary and secondary schools, and online activities such as I'm a Scientist Get Me Out of Here. From how to engage 8 year olds with making hydrographs more understandable to members of

  1. Declining functional connectivity and changing hub locations in Alzheimer's disease: an EEG study.

    Science.gov (United States)

    Engels, Marjolein M A; Stam, Cornelis J; van der Flier, Wiesje M; Scheltens, Philip; de Waal, Hanneke; van Straaten, Elisabeth C W

    2015-08-20

    EEG studies have shown that patients with Alzheimer's disease (AD) have weaker functional connectivity than controls, especially in higher frequency bands. Furthermore, active regions seem more prone to AD pathology. How functional connectivity is affected in AD subgroups of disease severity and how network hubs (highly connected brain areas) change is not known. We compared AD patients with different disease severity and controls in terms of functional connections, hub strength and hub location. We studied routine 21-channel resting-state electroencephalography (EEG) of 318 AD patients (divided into tertiles based on disease severity: mild, moderate and severe AD) and 133 age-matched controls. Functional connectivity between EEG channels was estimated with the Phase Lag Index (PLI). From the PLI-based connectivity matrix, the minimum spanning tree (MST) was derived. For each node (EEG channel) in the MST, the betweenness centrality (BC) was computed, a measure to quantify the relative importance of a node within the network. Then we derived color-coded head plots based on BC values and calculated the center of mass (the exact middle had x and y values of 0). A shifting of the hub locations was defined as a shift of the center of mass on the y-axis across groups. Multivariate general linear models with PLI or BC values as dependent variables and the groups as continuous variables were used in the five conventional frequency bands. We found that functional connectivity decreases with increasing disease severity in the alpha band. All, except for posterior, regions showed increasing BC values with increasing disease severity. The center of mass shifted from posterior to more anterior regions with increasing disease severity in the higher frequency bands, indicating a loss of relative functional importance of the posterior brain regions. In conclusion, we observed decreasing functional connectivity in the posterior regions, together with a shifted hub location from

  2. Looking into Pandora's Box: The Content of Sci-Hub and its Usage.

    Science.gov (United States)

    Greshake, Bastian

    2017-01-01

    Despite the growth of Open Access, potentially illegally circumventing paywalls to access scholarly publications is becoming a more mainstream phenomenon. The web service Sci-Hub is amongst the biggest facilitators of this, offering free access to around 62 million publications. So far it is not well studied how and why its users are accessing publications through Sci-Hub. By utilizing the recently released corpus of Sci-Hub and comparing it to the data of  ~28 million downloads done through the service, this study tries to address some of these questions. The comparative analysis shows that both the usage and complete corpus is largely made up of recently published articles, with users disproportionately favoring newer articles and 35% of downloaded articles being published after 2013. These results hint that embargo periods before publications become Open Access are frequently circumnavigated using Guerilla Open Access approaches like Sci-Hub. On a journal level, the downloads show a bias towards some scholarly disciplines, especially Chemistry, suggesting increased barriers to access for these. Comparing the use and corpus on a publisher level, it becomes clear that only 11% of publishers are highly requested in comparison to the baseline frequency, while 45% of all publishers are significantly less accessed than expected. Despite this, the oligopoly of publishers is even more remarkable on the level of content consumption, with 80% of all downloads being published through only 9 publishers. All of this suggests that Sci-Hub is used by different populations and for a number of different reasons, and that there is still a lack of access to the published scientific record. A further analysis of these openly available data resources will undoubtedly be valuable for the investigation of academic publishing.

  3. When is hub gene selection better than standard meta-analysis?

    Directory of Open Access Journals (Sweden)

    Peter Langfelder

    Full Text Available Since hub nodes have been found to play important roles in many networks, highly connected hub genes are expected to play an important role in biology as well. However, the empirical evidence remains ambiguous. An open question is whether (or when hub gene selection leads to more meaningful gene lists than a standard statistical analysis based on significance testing when analyzing genomic data sets (e.g., gene expression or DNA methylation data. Here we address this question for the special case when multiple genomic data sets are available. This is of great practical importance since for many research questions multiple data sets are publicly available. In this case, the data analyst can decide between a standard statistical approach (e.g., based on meta-analysis and a co-expression network analysis approach that selects intramodular hubs in consensus modules. We assess the performance of these two types of approaches according to two criteria. The first criterion evaluates the biological insights gained and is relevant in basic research. The second criterion evaluates the validation success (reproducibility in independent data sets and often applies in clinical diagnostic or prognostic applications. We compare meta-analysis with consensus network analysis based on weighted correlation network analysis (WGCNA in three comprehensive and unbiased empirical studies: (1 Finding genes predictive of lung cancer survival, (2 finding methylation markers related to age, and (3 finding mouse genes related to total cholesterol. The results demonstrate that intramodular hub gene status with respect to consensus modules is more useful than a meta-analysis p-value when identifying biologically meaningful gene lists (reflecting criterion 1. However, standard meta-analysis methods perform as good as (if not better than a consensus network approach in terms of validation success (criterion 2. The article also reports a comparison of meta-analysis techniques

  4. SPARK: Sparsity-based analysis of reliable k-hubness and overlapping network structure in brain functional connectivity.

    Science.gov (United States)

    Lee, Kangjoo; Lina, Jean-Marc; Gotman, Jean; Grova, Christophe

    2016-07-01

    Functional hubs are defined as the specific brain regions with dense connections to other regions in a functional brain network. Among them, connector hubs are of great interests, as they are assumed to promote global and hierarchical communications between functionally specialized networks. Damage to connector hubs may have a more crucial effect on the system than does damage to other hubs. Hubs in graph theory are often identified from a correlation matrix, and classified as connector hubs when the hubs are more connected to regions in other networks than within the networks to which they belong. However, the identification of hubs from functional data is more complex than that from structural data, notably because of the inherent problem of multicollinearity between temporal dynamics within a functional network. In this context, we developed and validated a method to reliably identify connectors and corresponding overlapping network structure from resting-state fMRI. This new method is actually handling the multicollinearity issue, since it does not rely on counting the number of connections from a thresholded correlation matrix. The novelty of the proposed method is that besides counting the number of networks involved in each voxel, it allows us to identify which networks are actually involved in each voxel, using a data-driven sparse general linear model in order to identify brain regions involved in more than one network. Moreover, we added a bootstrap resampling strategy to assess statistically the reproducibility of our results at the single subject level. The unified framework is called SPARK, i.e. SParsity-based Analysis of Reliable k-hubness, where k-hubness denotes the number of networks overlapping in each voxel. The accuracy and robustness of SPARK were evaluated using two dimensional box simulations and realistic simulations that examined detection of artificial hubs generated on real data. Then, test/retest reliability of the method was assessed

  5. Sharing environmental models: An Approach using GitHub repositories and Web Processing Services

    Science.gov (United States)

    Stasch, Christoph; Nuest, Daniel; Pross, Benjamin

    2016-04-01

    The GLUES (Global Assessment of Land Use Dynamics, Greenhouse Gas Emissions and Ecosystem Services) project established a spatial data infrastructure for scientific geospatial data and metadata (http://geoportal-glues.ufz.de), where different regional collaborative projects researching the impacts of climate and socio-economic changes on sustainable land management can share their underlying base scenarios and datasets. One goal of the project is to ease the sharing of computational models between institutions and to make them easily executable in Web-based infrastructures. In this work, we present such an approach for sharing computational models relying on GitHub repositories (http://github.com) and Web Processing Services. At first, model providers upload their model implementations to GitHub repositories in order to share them with others. The GitHub platform allows users to submit changes to the model code. The changes can be discussed and reviewed before merging them. However, while GitHub allows sharing and collaborating of model source code, it does not actually allow running these models, which requires efforts to transfer the implementation to a model execution framework. We thus have extended an existing implementation of the OGC Web Processing Service standard (http://www.opengeospatial.org/standards/wps), the 52°North Web Processing Service (http://52north.org/wps) platform to retrieve all model implementations from a git (http://git-scm.com) repository and add them to the collection of published geoprocesses. The current implementation is restricted to models implemented as R scripts using WPS4R annotations (Hinz et al.) and to Java algorithms using the 52°North WPS Java API. The models hence become executable through a standardized Web API by multiple clients such as desktop or browser GIS and modelling frameworks. If the model code is changed on the GitHub platform, the changes are retrieved by the service and the processes will be updated

  6. KINEMATIC ANALYSES OF THE GOLF SWING HUB PATH AND ITS ROLE IN GOLFER/CLUB KINETIC TRANSFERS

    Directory of Open Access Journals (Sweden)

    Steven M. Nesbit

    2009-06-01

    Full Text Available This study analyzed the fundamental geometric and kinematic characteristics of the swing hub path of the golf shot for four diverse subjects. In addition, the role of the hub path geometry in transferring the kinetic quantities from the golfer to the club were investigated. The hub path was found to have a complex geometry with significantly changing radii, and a constantly moving center-of-curvature during the downswing for all subjects. While the size and shape of the hub path differed considerably among the subjects, a three phase radius-based pattern was revealed that aligned with distinct stages of the downswing. Artificially controlling and optimizing the hub path of the better golfer in the group indicated that a non-circular hub path was superior to a constant radius path in minimizing the kinetic loading while generating the highest possible club head velocity. The shape and purpose of the hub path geometry appears to result from a complex combination of achieving equilibrium between the golfer and the club, and a purposeful configuring of the path to control the outward movement of the club while minimizing the kinetic loading on the golfer yet transferring the maximum kinetic quantities to the club. Describing the downswing relative to the hub path phasing is presented and was found to be informative since the phases align with significant swing, kinetic and kinematic markers. These findings challenge golf swing modeling methodologies which fix the center-of-curvature of the hub path thus constraining it to constant radius motion

  7. Microbial Hub Taxa Link Host and Abiotic Factors to Plant Microbiome Variation.

    Directory of Open Access Journals (Sweden)

    Matthew T Agler

    2016-01-01

    Full Text Available Plant-associated microorganisms have been shown to critically affect host physiology and performance, suggesting that evolution and ecology of plants and animals can only be understood in a holobiont (host and its associated organisms context. Host-associated microbial community structures are affected by abiotic and host factors, and increased attention is given to the role of the microbiome in interactions such as pathogen inhibition. However, little is known about how these factors act on the microbial community, and especially what role microbe-microbe interaction dynamics play. We have begun to address this knowledge gap for phyllosphere microbiomes of plants by simultaneously studying three major groups of Arabidopsis thaliana symbionts (bacteria, fungi and oomycetes using a systems biology approach. We evaluated multiple potential factors of microbial community control: we sampled various wild A. thaliana populations at different times, performed field plantings with different host genotypes, and implemented successive host colonization experiments under lab conditions where abiotic factors, host genotype, and pathogen colonization was manipulated. Our results indicate that both abiotic factors and host genotype interact to affect plant colonization by all three groups of microbes. Considering microbe-microbe interactions, however, uncovered a network of interkingdom interactions with significant contributions to community structure. As in other scale-free networks, a small number of taxa, which we call microbial "hubs," are strongly interconnected and have a severe effect on communities. By documenting these microbe-microbe interactions, we uncover an important mechanism explaining how abiotic factors and host genotypic signatures control microbial communities. In short, they act directly on "hub" microbes, which, via microbe-microbe interactions, transmit the effects to the microbial community. We analyzed two "hub" microbes (the

  8. From hub proteins to hub modules: the relationship between essentiality and centrality in the yeast interactome at different scales of organization.

    Directory of Open Access Journals (Sweden)

    Jimin Song

    Full Text Available Numerous studies have suggested that hub proteins in the S. cerevisiae physical interaction network are more likely to be essential than other proteins. The proposed reasons underlying this observed relationship between topology and functioning have been subject to some controversy, with recent work suggesting that it arises due to the participation of hub proteins in essential complexes and processes. However, do these essential modules themselves have distinct network characteristics, and how do their essential proteins differ in their topological properties from their non-essential proteins? We aimed to advance our understanding of protein essentiality by analyzing proteins, complexes and processes within their broader functional context and by considering physical interactions both within and across complexes and biological processes. In agreement with the view that essentiality is a modular property, we found that the number of intracomplex or intraprocess interactions that a protein has is a better indicator of its essentiality than its overall number of interactions. Moreover, we found that within an essential complex, its essential proteins have on average more interactions, especially intracomplex interactions, than its non-essential proteins. Finally, we built a module-level interaction network and found that essential complexes and processes tend to have higher interaction degrees in this network than non-essential complexes and processes; that is, they exhibit a larger amount of functional cross-talk than their non-essential counterparts.

  9. Omni directional mobile robot capable of variable foot printing based on hub type drive module

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyo Joong; Cho, Chang Nho; Kim, Hwi Su; Song, Jae Bok [Korea Univ., Seoul (Korea, Republic of)

    2012-03-15

    In recent years, an increased amount of research has been carried out on mobile robots to improve the performance of service robots. Mobile robots maximize the mobility of service robots, thus allowing them to work in different areas. However, conventional service robots have their center of mass placed high above the ground, which may cause them to fall when moving at high speed. Furthermore, hub type actuators, which are often used for mobile robots, are large and expensive. In this study, we propose a mobile robot with a hub type actuator unit and a variable footprint mechanism. The proposed variable footprint mechanism greatly improves the stability and mobility of the robot, allowing it to move freely in a narrow space and carry out various tasks. The performance of the proposed robot is verified experimentally.

  10. Replenishment policy and inventory optimization for supply-hub with liability period consideration

    Institute of Scientific and Technical Information of China (English)

    李果; 黄焜; 姚琦; 马士华

    2013-01-01

    A replenishment decision-making model for supply-hub is firstly established from the angle of supplier, and optimal replenishment decision of the supplier is analyzed. Then, inventory optimization model for supply-hub is formulated from the angle of the manufacturer, and the optimization algorithm for obtaining optimal inventory levels is given. The result shows that liability period decides the share of the inventory cost between two sides in supply chain. With the increase of liability period, the service level has been quickly reduced even though the manufacturer’s cost has been cut down by transferring the inventory cost to the supplier. As to the safety inventory, if the lower bound of components safety inventory increases, the supplier’s cost will rise up more slowly than the liability period does, while the service levels increases as the safety inventory’s lower bound is raised.

  11. Dynamic network participation of functional connectivity hubs assessed by resting-state fMRI

    Directory of Open Access Journals (Sweden)

    Alexander eSchaefer

    2014-05-01

    Full Text Available Network studies of large-scale brain connectivity have demonstrated that highly connected areas, or ‘hubs’, are a key feature of human functional and structural brain organization. We use resting-state functional MRI data and connectivity clustering to identify multi network hubs and show that while hubs can belong to multiple networks their degree of integration into these different networks varies dynamically over time. In addition, we found that these network dynamics were inversely related to positive self-generated thoughts reported by individuals and were further decreased with older age. Moreover, the left caudate varied its degree of participation between a default mode subnetwork and a limbic network. This variation was predictive of individual differences in the reports of past-related thoughts. These results support an association between ongoing thought processes and network dynamics and offer a new approach to investigate the brain dynamics underlying mental experience.

  12. Fast reversible learning based on neurons functioning as anisotropic multiplex hubs

    Science.gov (United States)

    Vardi, Roni; Goldental, Amir; Sheinin, Anton; Sardi, Shira; Kanter, Ido

    2017-05-01

    Neural networks are composed of neurons and synapses, which are responsible for learning in a slow adaptive dynamical process. Here we experimentally show that neurons act like independent anisotropic multiplex hubs, which relay and mute incoming signals following their input directions. Theoretically, the observed information routing enriches the computational capabilities of neurons by allowing, for instance, equalization among different information routes in the network, as well as high-frequency transmission of complex time-dependent signals constructed via several parallel routes. In addition, this kind of hubs adaptively eliminate very noisy neurons from the dynamics of the network, preventing masking of information transmission. The timescales for these features are several seconds at most, as opposed to the imprint of information by the synaptic plasticity, a process which exceeds minutes. Results open the horizon to the understanding of fast and adaptive learning realities in higher cognitive brain's functionalities.

  13. Clinical bioethics integration, sustainability, and accountability: the Hub and Spokes Strategy.

    Science.gov (United States)

    MacRae, S; Chidwick, P; Berry, S; Secker, B; Hébert, P; Shaul, R Zlotnik; Faith, K; Singer, P A

    2005-05-01

    The "lone" clinical bioethicist working in a large, multisite hospital faces considerable challenges. While attempting to build ethics capacity and sustain a demanding range of responsibilities, he or she must also achieve an acceptable level of integration, sustainability, and accountability within a complex organisational structure. In an effort to address such inherent demands and to create a platform towards better evaluation and effectiveness, the Clinical Ethics Group at the Joint Centre for Bioethics at the University of Toronto is implementing the Hub and Spokes Strategy at seven hospitals. The goal of the Hub and Spokes Strategy is to foster an ethical climate and strengthen ethics capacity broadly throughout healthcare settings as well as create models in clinical bioethics that are excellent and effective.

  14. Giant hub Src and Syk tyrosine kinase thermodynamic profiles recapitulate evolution

    Science.gov (United States)

    Phillips, J. C.

    2017-10-01

    Thermodynamic scaling theory, previously applied mainly to small proteins, here analyzes quantitative evolution of the titled functional network giant hub enzymes. The broad domain structure identified homologically is confirmed hydropathically using amino acid sequences only. The most surprising results concern the evolution of the tyrosine kinase globular surface roughness from avians to mammals, which is first order, compared to the evolution within mammals from rodents to humans, which is second order. The mystery of the unique amide terminal region of proto oncogene tyrosine protein kinase is resolved by the discovery there of a rare hydroneutral septad targeting cluster, which is paralleled by an equally rare octad catalytic cluster in tyrosine kinase in humans and a few other species (cat and dog). These results, which go far towards explaining why these proteins are among the largest giant hubs in protein interaction networks, use no adjustable parameters.

  15. Unveiling the early-stage anatomy of a protocluster hub with ALMA

    Science.gov (United States)

    Henshaw, J. D.; Jiménez-Serra, I.; Longmore, S. N.; Caselli, P.; Pineda, J. E.; Avison, A.; Barnes, A. T.; Tan, J. C.; Fontani, F.

    2017-01-01

    High-mass stars shape the interstellar medium in galaxies, and yet, largely because the initial conditions are poorly constrained, we do not know how they form. One possibility is that high-mass stars and star clusters form at the junction of filamentary networks, referred to as `hubs'. In this Letter we present the complex anatomy of a protocluster hub within an Infrared Dark Cloud (IRDC), G035.39-00.33, believed to be in an early phase of its evolution. We use high-angular resolution ({θmaj, θmin} = {1.4 arcsec, 0.8 arcsec} ˜ {0.02 pc, 0.01 pc}) and high-sensitivity (0.2 mJy beam-1; ˜0.2 M⊙) 1.07 mm dust continuum observations from the Atacama Large Millimeter Array (ALMA) to identify a network of narrow, 0.028 ± 0.005 pc wide, filamentary structures. These are a factor of ≳3 narrower than the proposed `quasi-universal' ˜0.1 pc width of interstellar filaments. Additionally, 28 compact objects are reported, spanning a mass range 0.3 M⊙ < Mc < 10.4 M⊙. This indicates that at least some low-mass objects are forming coevally with more massive counterparts. Comparing to the popular `bead-on-a-string' analogy, the protocluster hub is poorly represented by a monolithic clump embedded within a single filament. Instead, it comprises multiple intra-hub filaments, each of which retains its integrity as an independent structure and possesses its own embedded core population.

  16. Hub network design for sparse travel demand within the African aviation industry

    CSIR Research Space (South Africa)

    Ssamula, B

    2007-07-01

    Full Text Available as well as corruption leading to insufficient funds to manage national airlines. In order to align African Aviation with policies of deregulation and liberalisation already implemented in North America and Western Europe and to prevent the collapse... for each cluster was based on using the following factors: high passenger demand, infrastructure, technology advancement, number of flights operating, number of airlines operating, hub capabilities or function at airline or geographical level, as shown...

  17. Sensor Networks Hierarchical Optimization Model for Security Monitoring in High-Speed Railway Transport Hub

    Directory of Open Access Journals (Sweden)

    Zhengyu Xie

    2015-01-01

    Full Text Available We consider the sensor networks hierarchical optimization problem in high-speed railway transport hub (HRTH. The sensor networks are optimized from three hierarchies which are key area sensors optimization, passenger line sensors optimization, and whole area sensors optimization. Case study on a specific HRTH in China showed that the hierarchical optimization method is effective to optimize the sensor networks for security monitoring in HRTH.

  18. Wheels, hubs and spokes: incorporating a scorecard into a business continuity programme.

    Science.gov (United States)

    Stourac, Tracy

    2014-01-01

    A scorecard can provide much more than periodic measurements; it can actually serve as the 'hub' of a programme. By taking a strategic look at what one is trying to accomplish, using consistent messaging, following a flexible but defined process and creating an actionable report for the senior leadership, a programme can be built that not only gets attention but is also efficient and effective. The scorecard establishes accountability and consistency while creating a brand for a business continuity programme.

  19. Free vibrations of a flexible tapered arm attached to a compliant hub

    Science.gov (United States)

    Craver, W. Lionel, Jr.; Carrasco, Armando H.

    1991-05-01

    A single link flexible robot arm can be modeled as a Bernoulli Euler beam to describe its dynamic behavior. The first six natural frequencies for a flexible uniform beam attached to a compliant hub undergoing free vibration have previously been presented. This article extends the work to that of a linearly tapered robot arm. The equations of motion are presented and the characteristic determinant is derived. The determinant is then solved for the first five natural frequencies of the system.

  20. Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis.

    Science.gov (United States)

    Luo, Xiaoping; Guo, Linghong; Dai, Xi-Jian; Wang, Qinglai; Zhu, Wenzhong; Miao, Xinjun; Gong, Honghan

    2017-01-01

    To explore the abnormal intrinsic functional hubs in alcohol dependence using voxelwise degree centrality analysis approach, and their relationships with clinical features. Twenty-four male alcohol dependence subjects free of medicine (mean age, 50.21±9.62 years) and 24 age- and education-matched male healthy controls (mean age, 50.29±8.92 years) were recruited. The alcohol use disorders identification test and the severity of alcohol dependence questionnaire (SADQ) were administered to assess the severity of alcohol craving. Voxelwise degree centrality approach was used to assess the abnormal intrinsic functional hubs features in alcohol dependence. Simple linear regression analysis was performed to investigate the relationships between the clinical features and abnormal intrinsic functional hubs. Compared with healthy controls, alcohol dependence subjects exhibited significantly different degree centrality values in widespread left lateralization brain areas, including higher degree centrality values in the left precentral gyrus (BA 6), right hippocampus (BA 35, 36), and left orbitofrontal cortex (BA 11) and lower degree centrality values in the left cerebellum posterior lobe, bilateral secondary visual network (BA 18), and left precuneus (BA 7, 19). SADQ revealed a negative linear correlation with the degree centrality value in the left precentral gyrus (R(2)=0.296, P=0.006). The specific abnormal intrinsic functional hubs appear to be disrupted by alcohol intoxication, which implicates at least three principal neural systems: including cerebellar, executive control, and visual cortex, which may further affect the normal motor behavior such as an explicit type of impaired driving behavior. These findings expand our understanding of the functional characteristics of alcohol dependence and may provide a new insight into the understanding of the dysfunction and pathophysiology of alcohol dependence.

  1. Growing with Global Production Sharing: The Tale of Penang Export Hub

    OpenAIRE

    Prema-chandra Athukorala

    2011-01-01

    Global production sharing—the division of production processes into geographically separated stages—is a central feature of economic globalization. This study seeks to broaden our understanding of global production sharing, and to explore policy options for developing countries to engage effectively in production networks through a case study of the export production hub in the State of Penang, Malaysia. The findings uphold Penang as a unique example of marrying national development strat...

  2. Building a static website with Jekyll and GitHub Pages

    OpenAIRE

    Amanda Visconti

    2016-01-01

    This lesson is for you if you’d like an entirely free, easy-to-maintain, preservation-friendly, secure website over which you have full control, such as a scholarly blog, project website, or online portfolio. At the end of this lesson, you’ll have learned to use technology including Jekyll static site generation and GitHub Pages hosting to create a basic live website where you can publish content that other people can visit.

  3. Establishment of a Hub for the Light Water Reactor Sustainability Online Monitoring Community

    Energy Technology Data Exchange (ETDEWEB)

    Nancy J. Lybeck; Magdy S. Tawfik; Binh T. Pham

    2011-08-01

    Implementation of online monitoring and prognostics in existing U.S. nuclear power plants will involve coordinating the efforts of national laboratories, utilities, universities, and private companies. Internet-based collaborative work environments provide necessary communication tools to facilitate interaction between geographically diverse participants. Available technologies were considered, and a collaborative workspace was established at INL as a hub for the light water reactor sustainability online monitoring community.

  4. Smoking restrictions in large-hub airports --- United States, 2002 and 2010.

    Science.gov (United States)

    2010-11-19

    Secondhand smoke (SHS) exposure causes death and disease in both nonsmoking adults and children, including cancer, cardiovascular and respiratory diseases. SHS exposure causes an estimated 46,000 heart disease deaths and 3,400 lung cancer deaths among U.S. nonsmoking adults annually. Adopting policies that completely eliminate smoking in all indoor areas is the only effective way to eliminate involuntary SHS exposure. In 2009, an estimated 696 million aircraft passenger boardings occurred in the United States. A 2002 survey of airport smoking policies found that 42% of 31 large-hub U.S. airports had policies requiring all indoor areas to be smoke-free. To update that finding, CDC analyzed the smoking policies of airports categorized as large-hub in 2010. This report summarizes the results of that analysis, which found that, although 22 (76%) of the 29 large-hub airports surveyed were smoke-free indoors, seven airports permitted smoking in certain indoor locations, including three of the five busiest airports. Although a majority of airports reported having specifically designated smoking areas outdoors in 2010 (79%) and/or prohibiting smoking within a minimum distance of entryways (69%), no airport completely prohibited smoking on all airport property. Smoke-free policies at the state, local, or airport authority level are needed for all airports to protect air travelers and workers at airports from SHS.

  5. Penentuan Pelabuhan Hub untuk Crude Palm Oil (CPO Ekspor di Indonesia

    Directory of Open Access Journals (Sweden)

    Eko Andi Haranto

    2013-03-01

    Full Text Available CPO (Crude Palm Oil merupakan salah satu komoditi ekspor terbesar di Indonesia. Moda angkut darat dan sungai menjadi pilihan untuk didistribusikan menuju calon pelabuhan hub. Tugas Akhir ini bertujuan untuk merencanakan pola operasi armada pengangkut CPO, dan penentuan pelabuhan hub untuk ekspor CPO. Metode Transportasi digunakan untuk memilih pabrik pengolahan CPO sebagai pemasok utama. Dari hasil analisis didapatkan bahwa penggunaan moda darat menggunakan truk lebih optimal dibandingkan menggunakan tongkang hal ini dikarenakan kondisi sungai di Kalimantan Tengah yang dangkal. Dengan menggunakan metode transportasi didapatkan empat lokasi pabrik pengolahan minyak kelapa sawit. Pelabuhan hub yang terpilih berlokasi di Bagendang dan Bumi Harjo. Kedua titik tersebut dipilih karena sudah memiliki tangki timbun dan dermaga untuk ekspor CPO, selain itu pemilihan berdasarkan hasil analisa didapatkan biaya dari Pabrik PT. ATLANTIS ke Pelabuhan Bagendang dengan truk berukuran 10 ton memerlukan biaya sebesar Rp. 333.016,25/TRIP/TRUK. Pabrik PT. ATLANTIS II ke Pelabuhan Bagendang Rp. 237.868,75/TRIP/TRUK. Pabrik PT. TIGER ke Pelabuhan Bumi Harjo Rp. 475.737,50/TRIP/TRUK. PT. TIGER II merupakan pabrik yang dapat melakukan pengiriman langsung menggunakan tongkang berukuran 1800 DWT melewati sungai Barito, dengan biaya Rp.123.007.828,27,- /voyage.

  6. HIGH CYCLE FATIGUE RELIABILITY ANALYSIS ON ROTOR HUB BASED ON APPROXIMATION TECHNIQUE

    Institute of Scientific and Technical Information of China (English)

    姜年朝; 周光明; 张逊; 戴勇; 倪俊; 张志清

    2013-01-01

    A high cycle fatigue reliability analysis approach to helicopter rotor hub is proposed under working load spectrum .Automatic calculation for the approach is implemented through writing the calculating programs .In the system ,the modification of geometric model of rotor hub is controlled by several parameters ,and finite element method and S-N curve method are then employed to solve the fatigue life by automatically assigned parameters .A database between assigned parameters and fatigue life is obtained via Latin Hypercube Sampling (LHS) on toler-ance zone of rotor hub .Different data-fitting technologies are used and compared to determine a highest-precision approximation for this database .The parameters are assumed to be independent of each other and follow normal distributions .Fatigue reliability is then computed by the Monte Carlo (MC) method and the mean-value first order second moment (M FOSM ) method .Results show that the approach has high efficiency and precision ,and is suit-able for engineering application .

  7. A fractal growth model: Exploring the connection pattern of hubs in complex networks

    Science.gov (United States)

    Li, Dongyan; Wang, Xingyuan; Huang, Penghe

    2017-04-01

    Fractal is ubiquitous in many real-world networks. Previous researches showed that the strong disassortativity between the hub-nodes on all length scales was the key principle that gave rise to the fractal architecture of networks. Although fractal property emerged in some models, there were few researches about the fractal growth model and quantitative analyses about the strength of the disassortativity for fractal model. In this paper, we proposed a novel inverse renormalization method, named Box-based Preferential Attachment (BPA), to build the fractal growth models in which the Preferential Attachment was performed at box level. The proposed models provided a new framework that demonstrated small-world-fractal transition. Also, we firstly demonstrated the statistical characteristic of connection patterns of the hubs in fractal networks. The experimental results showed that, given proper growing scale and added edges, the proposed models could clearly show pure small-world or pure fractal or both of them. It also showed that the hub connection ratio showed normal distribution in many real-world networks. At last, the comparisons of connection pattern between the proposed models and the biological and technical networks were performed. The results gave useful reference for exploring the growth principle and for modeling the connection patterns for real-world networks.

  8. Scrubbing the hub of intravenous catheters with an alcohol wipe for 15 sec reduced neonatal sepsis.

    Science.gov (United States)

    Björkman, Louise; Ohlin, Andreas

    2015-03-01

    The aim of this study was to investigate whether scrubbing the hub of intravenous catheters with an alcohol wipe for 15 sec could reduce the incidence of neonatal sepsis in a level-three neonatal intensive care unit. We studied the incidence of neonatal sepsis caused by coagulase-negative staphylococci (CoNS) for 16.5 months before the initiative was launched on May 15, 2012 and then for a further 8.5 months after it was introduced. The hub routine was applied to all intravenous catheters. During the control period before the initiative was launched, there were nine cases of CoNS sepsis compared with no cases after it was introduced, resulting in a decrease in sepsis incidence from 1.5% to 0% with a risk reduction of 1.5% (0.53-2.58%) (p = 0.06). In the preterm infant population, the incidence of sepsis decreased from 3.6% to 0% (1.1-6.0%) (p = 0.11). Scrubbing the hub of intravenous catheters with an alcohol wipe for 15 sec seemed to be an efficient way of preventing sepsis caused by CoNS in newborn infants. However, the evidence for the benefits will remain weak until a large randomised trial has been completed. ©2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  9. Simulation study on three casting processes for a marine propeller hub body

    Directory of Open Access Journals (Sweden)

    Wang Tongmin

    2013-11-01

    Full Text Available The mold filling and solidification process of a marine propeller hub were simulated using ProCAST? Three casting processes ?gravity casting, centrifugal casting and low pressure casting ?were compared in order to get the best process. The heat transfer coefficient of the casting/mold interface was determined using a reverse method. The simulated results of velocity, temperature and shrinkage porosity distribution were discussed in detail for the three casting processes. A smooth filling was found in all three casting processes, especially the low pressure casting exhibiting a better filling performance than the other two, but the solidification processes were different. The casting did not experience the sequential solidification, and the feeding paths were blocked, leading to shrinkage porosity defects in the riser and the bottom of the casting in gravity casting and in the upper zone of the casting in low pressure casting. While, the sequential solidification was well controlled in the solidification process of centrifugal casting, and majority of the shrinkage porosity defects can only be observed in the riser. It could be concluded that the centrifugal casting process is the most suitable casting process for the production of propeller hub body. The casting experiments verified the simulation results, and a defect-free propeller hub was obtained by centrifugal casting with a rotational speed of 150 r.in-1.

  10. Multi-task connectivity reveals flexible hubs for adaptive task control

    Science.gov (United States)

    Cole, Michael W.; Reynolds, Jeremy R.; Power, Jonathan D.; Repovs, Grega; Anticevic, Alan; Braver, Todd S.

    2013-01-01

    Extensive evidence suggests the human ability to adaptively implement a wide variety of tasks is preferentially due to the operation of a fronto-parietal brain network. We hypothesized that this network’s adaptability is made possible by ‘flexible hubs’ – brain regions that rapidly update their pattern of global functional connectivity according to task demands. We utilized recent advances in characterizing brain network organization and dynamics to identify mechanisms consistent with the flexible hub theory. We found that the fronto-parietal network’s brain-wide functional connectivity pattern shifted more than other networks’ across a variety of task states, and that these connectivity patterns could be used to identify the current task. Further, these patterns were consistent across practiced and novel tasks, suggesting reuse of flexible hub connectivity patterns facilitates adaptive (novel) task performance. Together, these findings support a central role for fronto-parietal flexible hubs in cognitive control and adaptive implementation of task demands generally. PMID:23892552

  11. Unsteady Velocity Measurements Taken Behind a Model Helicopter Rotor Hub in Forward Flight

    Science.gov (United States)

    Berry, John D.

    1997-01-01

    Drag caused by separated flow behind the hub of a helicopter has an adverse effect on aerodynamic performance of the aircraft. To determine the effect of separated flow on a configuration used extensively for helicopter aerodynamic investigations, an experiment was conducted using a laser velocimeter to measure velocities in the wake of a model helicopter hub operating at Mach-scaled conditions in forward flight. Velocity measurements were taken using a laser velocimeter with components in the vertical and downstream directions. Measurements were taken at 13 stations downstream from the rotor hub. At each station, measurements were taken in both a horizontal and vertical row of locations. These measurements were analyzed for harmonic content based on the rotor period of revolution. After accounting for these periodic velocities, the remaining unsteady velocities were treated as turbulence. Turbulence intensity distributions are presented. Average turbulent intensities ranged from approximately 2 percent of free stream to over 15 percent of free stream at specific locations and azimuths. The maximum average value of turbulence was located near the rear-facing region of the fuselage.

  12. Characteristics of steady vibration in a rotating hub-beam system

    Science.gov (United States)

    Zhao, Zhen; Liu, Caishan; Ma, Wei

    2016-02-01

    A rotating beam features a puzzling character in which its frequencies and modal shapes may vary with the hub's inertia and its rotating speed. To highlight the essential nature behind the vibration phenomena, we analyze the steady vibration of a rotating Euler-Bernoulli beam with a quasi-steady-state stretch. Newton's law is used to derive the equations governing the beam's elastic motion and the hub's rotation. A combination of these equations results in a nonlinear partial differential equation (PDE) that fully reflects the mutual interaction between the two kinds of motion. Via the Fourier series expansion within a finite interval of time, we reduce the PDE into an infinite system of a nonlinear ordinary differential equation (ODE) in spatial domain. We further nondimensionalize the ODE and discretize it via a difference method. The frequencies and modal shapes of a general rotating beam are then determined numerically. For a low-speed beam where the ignorance of geometric stiffening is feasible, the beam's vibration characteristics are solved analytically. We validate our numerical method and the analytical solutions by comparing with either the past experiments or the past numerical findings reported in existing literature. Finally, systematic simulations are performed to demonstrate how the beam's eigenfrequencies vary with the hub's inertia and rotating speed.

  13. Continuous Integration for Concurrent MOOSE Framework and Application Development on GitHub

    Directory of Open Access Journals (Sweden)

    Andrew E. Slaughter

    2015-11-01

    Full Text Available For the past several years, Idaho National Laboratory’s MOOSE framework team has employed modern software engineering techniques (continuous integration, joint application/framework source code repos- itories, automated regression testing, etc. in developing closed-source multiphysics simulation software (Gaston et al., 'Journal of Open Research Software' vol. 2, article e10, 2014. In March 2014, the MOOSE framework was released under an open source license on GitHub, significantly expanding and diversifying the pool of current active and potential future contributors on the project. Despite this recent growth, the same philosophy of concurrent framework and application development continues to guide the project’s development roadmap. Several specific practices, including techniques for managing multiple repositories, conducting automated regression testing, and implementing a cascading build process are discussed in this short paper. Special attention is given to describing the manner in which these practices naturally synergize with the GitHub API and GitHub-specific features such as issue tracking, Pull Requests, and project forks.

  14. Toxické látky vyšších hub

    OpenAIRE

    Ascherová, Adriana

    2009-01-01

    Tato práce je věnovaná problematice toxických látek vyšších hub. Tematicky je rozčleněna do tří oddílů. V první části se zabývá chemickým složením hub, kde klade hlavní důraz na obsah těžkých kovů a léčivých látek. Následující oddíl je zaměřen na houby jedovaté, jejich nejvýznamnější zástupce a mechanismus působení jedů. Část třetí objasňuje problematiku hub jedlých a otravy, které mohou způsobit. Především se jedná o biogenní aminy, práce popisuje jejich chemické složení, vznik, strukturu a ...

  15. The air transportation hub-and-spoke design problem: comparison between a continuous and a discrete solution method

    Directory of Open Access Journals (Sweden)

    Guina Sotomayor Alzamora

    2013-12-01

    Full Text Available The hub-and-spoke network design problem, also known as the hub location problem, aims to find the concentration points in a given network flow so that the sum of the distances of the linkages is minimized. In this work, we compare discrete solutions of this problem, given by the branch-and-cut method applied to the p-hub median model, with continuous solutions, given by the hyperbolic smoothing technique applied to a min-sum-min model. Computational experiments for particular instances of the Brazilian air transportation system, with the number of hubs varying from 2 to 8, are conducted with the support of a discretization heuristic and the Voronoi diagram.

  16. HuB localizes to polysomes and alters C/EBP-beta expression in 3T3-L1 adipocytes.

    Science.gov (United States)

    Gantt, Kira R; Jain, Renu G; Dudek, Ronald W; Pekala, Phillip H

    2004-01-16

    The RNA binding protein HuB was ectopically expressed in 3T3-L1 preadipocytes and localized primarily to the nucleus, as the cells differentiated HuB redistributed to the cytosol and on analysis localized to the dense polysomes. Electron micrographs confirm association of HuB with the ribosomes in the adipocytes consistent with a proposed role in control of translation and mRNA stability. Examination of the expression of C/EBP-beta in the cells expressing HuB relative to the parental 3T3-L1 adipocytes demonstrated an alteration in the LAP to LIP ratio. The data support a role for endogenous Hu proteins in the differentiation process, potentially affecting the rate of differentiation by controlling the concentration of the dominant negative transcription inhibitor, LIP.

  17. Parametric Investigation of the Effect of Hub Pitching Moment on Blade Vortex Interaction (BVI) Noise of an Isolated Rotor

    Science.gov (United States)

    2016-05-19

    1 Parametric Investigation of the Effect of Hub Pitching Moment on Blade Vortex Interaction (BVI) Noise of an Isolated Rotor Carlos Malpica...radiation. Objective The aim of this study is to investigate the sensitivity of BVI noise radiation to changes in the hub pitch moment trim state...calculations the aerodynamic loads on the blades were evaluated at azimuth intervals of 15 deg. The relatively large time (azimuth) step is

  18. Dynamically Allocated Hub in Task-Evoked Network Predicts the Vulnerable Prefrontal Locus for Contextual Memory Retrieval in Macaques.

    Directory of Open Access Journals (Sweden)

    Takahiro Osada

    2015-06-01

    Full Text Available Neuroimaging and neurophysiology have revealed that multiple areas in the prefrontal cortex (PFC are activated in a specific memory task, but severity of impairment after PFC lesions is largely different depending on which activated area is damaged. The critical relationship between lesion sites and impairments has not yet been given a clear mechanistic explanation. Although recent works proposed that a whole-brain network contains hubs that play integrative roles in cortical information processing, this framework relying on an anatomy-based structural network cannot account for the vulnerable locus for a specific task, lesioning of which would bring impairment. Here, we hypothesized that (i activated PFC areas dynamically form an ordered network centered at a task-specific "functional hub" and (ii the lesion-effective site corresponds to the "functional hub," but not to a task-invariant "structural hub." To test these hypotheses, we conducted functional magnetic resonance imaging experiments in macaques performing a temporal contextual memory task. We found that the activated areas formed a hierarchical hub-centric network based on task-evoked directed connectivity, differently from the anatomical network reflecting axonal projection patterns. Using a novel simulated-lesion method based on support vector machine, we estimated severity of impairment after lesioning of each area, which accorded well with a known dissociation in contextual memory impairment in macaques (impairment after lesioning in area 9/46d, but not in area 8Ad. The predicted severity of impairment was proportional to the network "hubness" of the virtually lesioned area in the task-evoked directed connectivity network, rather than in the anatomical network known from tracer studies. Our results suggest that PFC areas dynamically and cooperatively shape a functional hub-centric network to reallocate the lesion-effective site depending on the cognitive processes, apart from

  19. Dynamically Allocated Hub in Task-Evoked Network Predicts the Vulnerable Prefrontal Locus for Contextual Memory Retrieval in Macaques.

    Science.gov (United States)

    Osada, Takahiro; Adachi, Yusuke; Miyamoto, Kentaro; Jimura, Koji; Setsuie, Rieko; Miyashita, Yasushi

    2015-06-01

    Neuroimaging and neurophysiology have revealed that multiple areas in the prefrontal cortex (PFC) are activated in a specific memory task, but severity of impairment after PFC lesions is largely different depending on which activated area is damaged. The critical relationship between lesion sites and impairments has not yet been given a clear mechanistic explanation. Although recent works proposed that a whole-brain network contains hubs that play integrative roles in cortical information processing, this framework relying on an anatomy-based structural network cannot account for the vulnerable locus for a specific task, lesioning of which would bring impairment. Here, we hypothesized that (i) activated PFC areas dynamically form an ordered network centered at a task-specific "functional hub" and (ii) the lesion-effective site corresponds to the "functional hub," but not to a task-invariant "structural hub." To test these hypotheses, we conducted functional magnetic resonance imaging experiments in macaques performing a temporal contextual memory task. We found that the activated areas formed a hierarchical hub-centric network based on task-evoked directed connectivity, differently from the anatomical network reflecting axonal projection patterns. Using a novel simulated-lesion method based on support vector machine, we estimated severity of impairment after lesioning of each area, which accorded well with a known dissociation in contextual memory impairment in macaques (impairment after lesioning in area 9/46d, but not in area 8Ad). The predicted severity of impairment was proportional to the network "hubness" of the virtually lesioned area in the task-evoked directed connectivity network, rather than in the anatomical network known from tracer studies. Our results suggest that PFC areas dynamically and cooperatively shape a functional hub-centric network to reallocate the lesion-effective site depending on the cognitive processes, apart from static anatomical

  20. Brokered virtual hubs for facilitating access and use of geospatial Open Data

    Science.gov (United States)

    Mazzetti, Paolo; Latre, Miguel; Kamali, Nargess; Brumana, Raffaella; Braumann, Stefan; Nativi, Stefano

    2016-04-01

    Open Data is a major trend in current information technology scenario and it is often publicised as one of the pillars of the information society in the near future. In particular, geospatial Open Data have a huge potential also for Earth Sciences, through the enablement of innovative applications and services integrating heterogeneous information. However, open does not mean usable. As it was recognized at the very beginning of the Web revolution, many different degrees of openness exist: from simple sharing in a proprietary format to advanced sharing in standard formats and including semantic information. Therefore, to fully unleash the potential of geospatial Open Data, advanced infrastructures are needed to increase the data openness degree, enhancing their usability. In October 2014, the ENERGIC OD (European NEtwork for Redistributing Geospatial Information to user Communities - Open Data) project, funded by the European Union under the Competitiveness and Innovation framework Programme (CIP), has started. In response to the EU call, the general objective of the project is to "facilitate the use of open (freely available) geographic data from different sources for the creation of innovative applications and services through the creation of Virtual Hubs". The ENERGIC OD Virtual Hubs aim to facilitate the use of geospatial Open Data by lowering and possibly removing the main barriers which hampers geo-information (GI) usage by end-users and application developers. Data and services heterogeneity is recognized as one of the major barriers to Open Data (re-)use. It imposes end-users and developers to spend a lot of effort in accessing different infrastructures and harmonizing datasets. Such heterogeneity cannot be completely removed through the adoption of standard specifications for service interfaces, metadata and data models, since different infrastructures adopt different standards to answer to specific challenges and to address specific use-cases. Thus

  1. The FUTUREVOLC Supersite's e-Infrastructure - A multidisciplinary data hub and data service for Icelandic Volcanoes

    Science.gov (United States)

    Vogfjörd, Kristín S.; Sigmundsson, Freysteinn; Sverrisson, Sverrir Th.; Sigurdsson, Sigurdur F.; Ófeigsson, Benedikt G.; Arnarsson, Ólafur S.; Kristinsson, Ingvar; Ilyinskaya, Evgenia; Oddsdóttir, Thorarna Ýr; Bergsveinsson, Sölvi Th.; Hjartansson, Kristján R.

    2014-05-01

    The FUTUREVOLC volanological supersite will establish a data hub and dataservice, where researchers, hazard managers and other stake holders can freely obtain access to multidisciplinary data and products on activity, unrest and eruptions at Icelandic volcanoes. The supersite is firmly founded on close interaction between the main Icelandic volcanological research and monitoring institutions, in coordination with expertise from European researchers participating in FUTUREVOLC. The hub is located at the Icelandic Meteorological Office (IMO), an institution responsible for monitoring and archiving data on all natural hazards in Iceland and, which also has a mandate as the state volcano observatory. This association will ensure a long-term sustainable data service. The data accessible at the hub include in-situ and space-based observations, products and models from all the relevant disciplines contributing to volcanological research and local as well as cross-border hazard management, i.e. Earth sciences, atmospheric science, hydrology, remote sensing and space science. Access to the data will be in compliance with the access policy of the GEO (Group on Earth Observations), providing registered users with easy and timely access to data and products of documented quality. This commitment has already led to the acceptance of FUTUREVOLC as a permanent geohazard supersite by CEOS (Committee on Earth Observation Satellites), which will ensure access to additional satellite data and products on Icelandic volcanoes. To facilitate services to seismological data at the supersite hub, the IMO is reconstructing its existing data base and utilizing the SeisComp3 software to manage waveform and parameter data. The accompanying ArcLink component will be used to provide access to event data and waveforms. Access to GPS data will be provided by the GSAC web service which has been installed at the IMO through collaboration with UNAVCO. If appropriate, the format and data base

  2. Lazy Updating of hubs can enable more realistic models by speeding up stochastic simulations

    Energy Technology Data Exchange (ETDEWEB)

    Ehlert, Kurt; Loewe, Laurence, E-mail: loewe@wisc.edu [Laboratory of Genetics, University of Wisconsin-Madison, Madison, Wisconsin 53706 (United States); Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin 53715 (United States)

    2014-11-28

    To respect the nature of discrete parts in a system, stochastic simulation algorithms (SSAs) must update for each action (i) all part counts and (ii) each action's probability of occurring next and its timing. This makes it expensive to simulate biological networks with well-connected “hubs” such as ATP that affect many actions. Temperature and volume also affect many actions and may be changed significantly in small steps by the network itself during fever and cell growth, respectively. Such trends matter for evolutionary questions, as cell volume determines doubling times and fever may affect survival, both key traits for biological evolution. Yet simulations often ignore such trends and assume constant environments to avoid many costly probability updates. Such computational convenience precludes analyses of important aspects of evolution. Here we present “Lazy Updating,” an add-on for SSAs designed to reduce the cost of simulating hubs. When a hub changes, Lazy Updating postpones all probability updates for reactions depending on this hub, until a threshold is crossed. Speedup is substantial if most computing time is spent on such updates. We implemented Lazy Updating for the Sorting Direct Method and it is easily integrated into other SSAs such as Gillespie's Direct Method or the Next Reaction Method. Testing on several toy models and a cellular metabolism model showed >10× faster simulations for its use-cases—with a small loss of accuracy. Thus we see Lazy Updating as a valuable tool for some special but important simulation problems that are difficult to address efficiently otherwise.

  3. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden

    Science.gov (United States)

    Drzezga, Alexander; Van Dijk, Koene R. A.; Sreenivasan, Aishwarya; Talukdar, Tanveer; Sullivan, Caroline; Schultz, Aaron P.; Sepulcre, Jorge; Putcha, Deepti; Greve, Doug; Johnson, Keith A.; Sperling, Reisa A.

    2011-01-01

    Disruption of functional connectivity between brain regions may represent an early functional consequence of β-amyloid pathology prior to clinical Alzheimer's disease. We aimed to investigate if non-demented older individuals with increased amyloid burden demonstrate disruptions of functional whole-brain connectivity in cortical hubs (brain regions typically highly connected to multiple other brain areas) and if these disruptions are associated with neuronal dysfunction as measured with fluorodeoxyglucose-positron emission tomography. In healthy subjects without cognitive symptoms and patients with mild cognitive impairment, we used positron emission tomography to assess amyloid burden and cerebral glucose metabolism, structural magnetic resonance imaging to quantify atrophy and novel resting state functional magnetic resonance imaging processing methods to calculate whole-brain connectivity. Significant disruptions of whole-brain connectivity were found in amyloid-positive patients with mild cognitive impairment in typical cortical hubs (posterior cingulate cortex/precuneus), strongly overlapping with regional hypometabolism. Subtle connectivity disruptions and hypometabolism were already present in amyloid-positive asymptomatic subjects. Voxel-based morphometry measures indicate that these findings were not solely a consequence of regional atrophy. Whole-brain connectivity values and metabolism showed a positive correlation with each other and a negative correlation with amyloid burden. These results indicate that disruption of functional connectivity and hypometabolism may represent early functional consequences of emerging molecular Alzheimer's disease pathology, evolving prior to clinical onset of dementia. The spatial overlap between hypometabolism and disruption of connectivity in cortical hubs points to a particular susceptibility of these regions to early Alzheimer's-type neurodegeneration and may reflect a link between synaptic dysfunction and functional

  4. Interpatch foraging in honeybees-rational decision making at secondary hubs based upon time and motivation.

    Science.gov (United States)

    Najera, Daniel A; McCullough, Erin L; Jander, Rudolf

    2012-11-01

    For honeybees, Apis mellifera, the hive has been well known to function as a primary decision-making hub, a place from which foragers decide among various directions, distances, and times of day to forage efficiently. Whether foraging honeybees can make similarly complex navigational decisions from locations away from the hive is unknown. To examine whether or not such secondary decision-making hubs exist, we trained bees to forage at four different locations. Specifically, we trained honeybees to first forage to a distal site "CT" 100 m away from the hive; if food was present, they fed and then chose to go home. If food was not present, the honeybees were trained to forage to three auxiliary sites, each at a different time of the day: A in the morning, B at noon, and C in the afternoon. The foragers learned to check site CT for food first and then efficiently depart to the correct location based upon the time of day if there was no food at site CT. Thus, the honeybees were able to cognitively map motivation, time, and five different locations (Hive, CT, A, B, and C) in two spatial dimensions; these are the contents of the cognitive map used by the honeybees here. While at site CT, we verified that the honeybees could choose between 4 different directions (to A, B, C, and the Hive) and thus label it as a secondary decision-making hub. The observed decision making uncovered here is inferred to constitute genuine logical operations, involving a branched structure, based upon the premises of motivational state, and spatiotemporal knowledge.

  5. Hubs and Authorities of the English Premier League for 2010-2011

    OpenAIRE

    Leznik, Michael

    2013-01-01

    In this work author applies well known web search algorithm Hyperlink - Induced Topic Search (HITS) to problem of ranking football teams in English Premier League (EPL). The algorithm allows the ranking of the teams using the notions of hubs and authorities well known for ranking pages in the World Wide Web. Results of the games introduced as a graph where losing team 'gives a link' to a winning team and, if draw registered both team give links to each other. In case of a win link is weighted...

  6. Home health monitoring – EyKos HealthHub (product design concept)

    OpenAIRE

    Phillips, Mark; Dulake, Nick; Willox, Matt; Gwilt, Ian; Craig, Claire; Auton, Kevin

    2015-01-01

    This work focused on creating a product design concept for a home health monitoring system, known as EyKos HealthHub, which is intended to be a ‘crossover product’ in the emerging medical/consumer product space. Working collaboratively with Aseptika Ltd, the team carried out product concept design and interaction design for the EyKos system, and undertook further design and prototyping work to create an object for use in research. Aseptika is carrying out technical development of this project...

  7. A New Approach for Offshore Wind Farm Energy Yields Calculation with Mixed Hub Height Wind Turbines

    DEFF Research Database (Denmark)

    Hou, Peng; Hu, Weihao; Soltani, Mohsen

    2016-01-01

    In this paper, a mathematical model for calculating the energy yields of offshore wind farm with mixed types of wind turbines is proposed. The Jensen model is selected as the base and developed to a three dimension wake model to estimate the energy yields. Since the wind turbines are with different...... hub heights, the wind shear effect is also taken into consideration. The results show that the proposed wake model is effective in calculating the wind speed deficit. The calculation framework is applicable for energy yields calculation in offshore wind farms....

  8. Unveiling Exception Handling Bug Hazards in Android Based on GitHub and Google Code Issues

    OpenAIRE

    Coelho, R.; L. Almeida; Gousios, G.; Van Deursen, A.

    2015-01-01

    This paper reports on a study mining the exception stack traces included in 159,048 issues reported on Android projects hosted in GitHub (482 projects) and Google Code (157 projects). The goal of this study is to investigate whether stack trace information can reveal bug hazards related to exception handling code that may lead to a decrease in application robustness. Overall 6,005 exception stack traces were extracted, and subjected to source code and bytecode analysis. The outcomes of this s...

  9. Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis

    Directory of Open Access Journals (Sweden)

    Luo X

    2017-07-01

    Full Text Available Xiaoping Luo,1,2 Linghong Guo,1 Xi-Jian Dai,3 Qinglai Wang,2 Wenzhong Zhu,2 Xinjun Miao,2 Honghan Gong1 1Department of Radiology, The First Affiliated Hospital of Nanchang University, Nangchang, Jiangxi, People’s Republic of China; 2Department of Radiology, Wenzhou Chinese Medicine Hospital, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People’s Republic of China Objective: To explore the abnormal intrinsic functional hubs in alcohol dependence using voxelwise degree centrality analysis approach, and their relationships with clinical features.Materials and methods: Twenty-four male alcohol dependence subjects free of medicine (mean age, 50.21±9.62 years and 24 age- and education-matched male healthy controls (mean age, 50.29±8.92 years were recruited. The alcohol use disorders identification test and the severity of alcohol dependence questionnaire (SADQ were administered to assess the severity of alcohol craving. Voxelwise degree centrality approach was used to assess the abnormal intrinsic functional hubs features in alcohol dependence. Simple linear regression analysis was performed to investigate the relationships between the clinical features and abnormal intrinsic functional hubs.Results: Compared with healthy controls, alcohol dependence subjects exhibited significantly different degree centrality values in widespread left lateralization brain areas, including higher degree centrality values in the left precentral gyrus (BA 6, right hippocampus (BA 35, 36, and left orbitofrontal cortex (BA 11 and lower degree centrality values in the left cerebellum posterior lobe, bilateral secondary visual network (BA 18, and left precuneus (BA 7, 19. SADQ revealed a negative linear correlation with the degree centrality value in the left precentral gyrus (R2=0.296, P=0.006.Conclusion: The specific abnormal intrinsic functional hubs appear

  10. Control design for two-bladed wind turbines

    NARCIS (Netherlands)

    Van Solingen, E.

    2015-01-01

    In the past decades wind energy has evolved into a mature source of sustainable energy such that onshore wind turbines have become cost competitive with other fossil-based energy sources. Onshore wind energy, however, faces social resistance and a lack of available locations. Offshore wind energy,

  11. Control design for two-bladed wind turbines

    NARCIS (Netherlands)

    Van Solingen, E.

    2015-01-01

    In the past decades wind energy has evolved into a mature source of sustainable energy such that onshore wind turbines have become cost competitive with other fossil-based energy sources. Onshore wind energy, however, faces social resistance and a lack of available locations. Offshore wind energy,

  12. Real-Time Monitoring and Fault Diagnosis of a Low Power Hub Motor Using Feedforward Neural Network

    Directory of Open Access Journals (Sweden)

    Mehmet Şimşir

    2016-01-01

    Full Text Available Low power hub motors are widely used in electromechanical systems such as electrical bicycles and solar vehicles due to their robustness and compact structure. Such systems driven by hub motors (in wheel motors encounter previously defined and undefined faults under operation. It may inevitably lead to the interruption of the electromechanical system operation; hence, economic losses take place at certain times. Therefore, in order to maintain system operation sustainability, the motor should be precisely monitored and the faults are diagnosed considering various significant motor parameters. In this study, the artificial feedforward backpropagation neural network approach is proposed to real-time monitor and diagnose the faults of the hub motor by measuring seven main system parameters. So as to construct a necessary model, we trained the model, using a data set consisting of 4160 samples where each has 7 parameters, by the MATLAB environment until the best model is obtained. The results are encouraging and meaningful for the specific motor and the developed model may be applicable to other types of hub motors. The prosperous model of the whole system was embedded into Arduino Due microcontroller card and the mobile real-time monitoring and fault diagnosis system prototype for hub motor was designed and manufactured.

  13. Design and Analysis of a Novel Speed-Changing Wheel Hub with an Integrated Electric Motor for Electric Bicycles

    Directory of Open Access Journals (Sweden)

    Yi-Chang Wu

    2013-01-01

    Full Text Available The aim of this paper is to present an innovative electromechanical device which integrates a brushless DC (BLDC hub motor with a speed-changing wheel hub stored on the rear wheel of an electric bicycle. It combines a power source and a speed-changing mechanism to simultaneously provide functions of power generation and transmission for electric bicycles. As part of the proposed integrated device, the wheel hub consists of a basic planetary gear train providing three forward speeds including a low-speed gear, a direct drive, and a high-speed gear. Each gear is manually controlled by the shift control sleeve to selectively engage or disengage four pawl-and-ratchet clutches based on its clutching sequence table. The number of gear teeth of each gear element of the wheel hub is synthesized. The BLDC hub motor is an exterior-rotor-type permanent-magnet synchronous motor. Two-dimensional finite-element analysis (FEA software is employed to facilitate the motor design and performance analysis. An analysis of the power transmission path at each gear is provided to verify the validity of the proposed design. The results of this work are beneficial to the embodiment, design, and development of novel electromechanical devices for the power and transmission systems of electric bicycles.

  14. Sources of fatigue damage to passive yaw wind turbine blades

    Energy Technology Data Exchange (ETDEWEB)

    Laino, D.J. [Univ. of Utah, Salt Lake City, UT (United States)

    1997-12-31

    Using an integrated computer analysis approach developed at the University of Utah, fatigue damage sources to passive yaw wind turbine blades have been investigated. Models of a rigid hub and teetering hub machine reveal the parameters important to the fatigue design of each type. The teetering hub proved much less susceptible to fatigue damage from normal operation loads. As a result, extreme events were critical to the teetering hub fatigue life. The rigid hub blades experienced extremely large gyroscopic load cycles induced by rapid yaw rates during normal operation. These yaw rates stem from turbulence activity which is shown to be dependent upon atmospheric stability. Investigation revealed that increasing yaw damping is an effective way of significantly reducing these gyroscopic fatigue loads.

  15. What is controlling the fragmentation process in the Infrared Dark Cloud G14.225-0.506? Differet level of fragmentation in twin hubs

    CERN Document Server

    Busquet, G; Palau, A; Liu, H B; Zhang, Q; Girart, J M; de Gregorio-Monsalvo, I; Pillai, T; Anglada, G; Ho, P T P

    2016-01-01

    We present observations of the 1.3 mm continuum emission toward hub-N and hub-S of the infrared dark cloud G14.225-0.506 carried out with the Submillimeter Array, together with observations of the dust emission at 870 and 350 microns obtained with APEX and CSO telescopes. The large scale dust emission of both hubs consists of a single peaked clump elongated in the direction of the associated filament. At small scales, the SMA images reveal that both hubs fragment into several dust condensations. The fragmentation level was assessed under the same conditions and we found that hub-N presents 4 fragments while hub-S is more fragmented, with 13 fragments identified. We studied the density structure by means of a simultaneous fit of the radial intensity profile at 870 and 350 microns and the spectral energy distribution adopting a Plummer-like function to describe the density structure. The parameters inferred from the model are remarkably similar in both hubs, suggesting that density structure could not be respon...

  16. Special Operations Aerial Mobility Vehicle Training Syllabus

    Science.gov (United States)

    2013-12-01

    powered glider. (9) A fixed-pitch, semi-rigid, teetering, two- blade rotor system, if a gyroplane...Kts) Notes NorthWing Apache XC $55K 2 490 335 780 65 Soft, folding wing ParaJet Sky Runner $118 K 1 500 200 100 55 Collapsing wing

  17. Reviewing the Justice and Security Hub Modality as Piloted in Liberia

    Directory of Open Access Journals (Sweden)

    Rory Keane

    2012-11-01

    Full Text Available ‘The Republic of Bangui’ or ‘the Republic of Monrovia’ are phrases we sometimes hear from practitioners to describe post conflict countries where very few services exist outside the capital city. This is especially the case for security – the critical public good in post conflict countries. In response to the need to bring security services closer to the citizens who often need them most, the Government of Liberia and the United Nations are piloting a new approach financed by the UN Peacebuilding Fund (PBF – the so-called ‘Justice and Security Hubs’. The donor community and the United Nations are watching closely. If this works, there is indication from UN officials that the model could potentially be replicated in other settings such as the East of the Democratic Republic of the Congo (DRC, Haiti and the northern states of South Sudan. If the hub concept is capable of being adapted and successful elsewhere, the United Nations will not only have added a new instrument to its peacekeeping toolkit but will also firmly demonstrate how the UN Peacebuilding Fund can in essence be catalytic in fostering long-term and comprehensive approaches to peacebuilding. This practice note outlines the process of developing and constructing the first hub in Liberia, which is due to be partly operational by the end of 2012, and provides a prognosis on its chances for success.

  18. Of Hubs and Hinterlands: Cyprus as an Insular Space of Overlapping Diasporas

    Directory of Open Access Journals (Sweden)

    Russell King

    2012-05-01

    Full Text Available This paper uses the metaphor of diasporic hubs and hinterlands to document and analyse the various diasporic formations that overlap and encounter each other on the divided island of Cyprus. After a review of the various ways that islands interface with migration processes and some essential historical and statistical background on Cyprus and its population, the paper considers a number of migrations/diasporas that are based on or affect the island. They include the emigration from the diasporic hub of Cyprus during the 1950s-1970s; return migration, both of the original emigrants and their descendants; the British military/colonial settlement of Cyprus; retirees and ‘lifestyle migrants’; and various categories of recent immigrants, for whom Cyprus is a diasporic hinterland. We draw both similarities and differences between migratory dynamics in the northern, Turkish Cypriot part of the island and the southern, Greek Cypriot part. In the final part of the paper we describe recent fieldwork on various spaces of inter-diasporic encounter in Cyprus.

  19. EXPANSION OF UNIVERSITY EDUCATION, GRADUATE UNEMPLOYMENT AND THE KNOWLEDGE HUB IN SRI LANKA

    Directory of Open Access Journals (Sweden)

    Gamini Samaranayake

    2016-04-01

    Full Text Available The main objective of this paper is to examine the nexus between the existing university education system and graduate unemployment, and to explore the responses of successive governments to address this issue. It also examines the viability and potential of the knowledge hub as a solution to graduate unemployment. Towards this end, it argues that the solution to graduate employment lies in implementing structural changes that are concurrent to changes that are taking place at the international level in higher education. It illustrates, with the use of relevant sources, the pressing issue of graduate un- and underemployment, and identifies the mismatch between skills and requirements as a major factor contributing to intensify the crisis. It observes that strategies such as training unemployed graduates to enable them to acquire the competencies needed for the modern work place, developing systems to link them to the world of work, re-structuring the university system such that it is more concerned with quality and relevance rather than the width of knowledge imparted, and introducing job-oriented programmes could partially address this issue. It also identifies the proposal to establish a knowledge hub in Sri Lanka as constituting a long term and sustainable strategy not only to mitigate the effects of graduate un- and underemployment, but also to facilitate a lucrative source of revenue for the country.

  20. Unveiling the Early-Stage Anatomy of a Protocluster Hub with ALMA

    CERN Document Server

    Henshaw, J D; Longmore, S N; Caselli, P; Pineda, J E; Avison, A; Barnes, A T; Tan, J C; Fontani, F

    2016-01-01

    High-mass stars shape the interstellar medium in galaxies, and yet, largely because the initial conditions are poorly constrained, we do not know how they form. One possibility is that high-mass stars and star clusters form at the junction of filamentary networks, referred to as "hubs". In this letter we present the complex anatomy of a protocluster hub within an Infrared Dark Cloud (IRDC), G035.39-00.33, believed to be in an early phase of its evolution. We use high-angular resolution ($\\{\\theta_{\\rm maj}, \\theta_{\\rm min}\\}=\\{1.''4, 0.''8\\}\\sim\\{0.02\\,{\\rm pc}, 0.01\\,{\\rm pc}\\}$) and high-sensitivity ($0.2$ mJy beam$^{-1}$; $\\sim0.2$ M$_{\\odot}$) 1.07 mm dust continuum observations from the Atacama Large Millimeter Array (ALMA) to identify a network of narrow, $0.028\\,\\pm\\,0.005$ pc wide, filamentary structures. These are a factor of $\\gtrsim3$ narrower than the proposed "quasi-universal" $\\sim0.1$ pc width of interstellar filaments. Additionally, 28 compact objects are reported, spanning a mass range $0.3\\...

  1. Clique of functional hubs orchestrates population bursts in developmentally regulated neural networks

    Science.gov (United States)

    Torcini, Alessandro; Luccioli, Stefano; Bonifazi, Paolo; Ben-Jacob, Eshel; Barzilai, Ari

    2015-03-01

    It has recently been discovered that single neuron stimulation can impact network dynamics in immature and adult neuronal circuits. Here we report a novel mechanism which can explain in developing neuronal circuits, typically composed of only excitatory cells, the peculiar role played by a few specific neurons in promoting/arresting the population activity. For this purpose, we consider a standard neuronal network model, with short-term synaptic plasticity, whose population activity is characterized by bursting behavior. The addition of developmentally regulated constraints on single neuron excitability and connectivity leads to the emergence of functional hub neurons, whose stimulation/deletion is critical for the network activity. Functional hubs form a clique, where a precise sequential activation of the neurons is essential to ignite collective events without any need for a specific topological architecture. Unsupervised time-lagged firings of supra-threshold cells, in connection with coordinated entrainments of near-threshold neurons, are the key ingredients to orchestrate population activity. This work is part of the activity of the Joint Italian-Israeli Laboratory on Integrative Network Neuroscience supported by the Italian Ministry of Foreign Affairs.

  2. Bottlenecks and hubs in inferred networks are important for virulence in Salmonella typhimurium.

    Science.gov (United States)

    McDermott, Jason E; Taylor, Ronald C; Yoon, Hyunjin; Heffron, Fred

    2009-02-01

    Recent advances in experimental methods have provided sufficient data to consider systems as large networks of interconnected components. High-throughput determination of protein-protein interaction networks has led to the observation that topological bottlenecks, proteins defined by high centrality in the network, are enriched in proteins with systems-level phenotypes such as essentiality. Global transcriptional profiling by microarray analysis has been used extensively to characterize systems, for example, examining cellular response to environmental conditions and effects of genetic mutations. These transcriptomic datasets have been used to infer regulatory and functional relationship networks based on co-regulation. We use the context likelihood of relatedness (CLR) method to infer networks from two datasets gathered from the pathogen Salmonella typhimurium: one under a range of environmental culture conditions and the other from deletions of 15 regulators found to be essential in virulence. Bottleneck and hub genes were identified from these inferred networks, and we show for the first time that these genes are significantly more likely to be essential for virulence than their non-bottleneck or non-hub counterparts. Networks generated using simple similarity metrics (correlation and mutual information) did not display this behavior. Overall, this study demonstrates that topology of networks inferred from global transcriptional profiles provides information about the systems-level roles of bottleneck genes. Analysis of the differences between the two CLR-derived networks suggests that the bottleneck nodes are either mediators of transitions between system states or sentinels that reflect the dynamics of these transitions.

  3. Clique of functional hubs orchestrates population bursts in developmentally regulated neural networks.

    Directory of Open Access Journals (Sweden)

    Stefano Luccioli

    2014-09-01

    Full Text Available It has recently been discovered that single neuron stimulation can impact network dynamics in immature and adult neuronal circuits. Here we report a novel mechanism which can explain in neuronal circuits, at an early stage of development, the peculiar role played by a few specific neurons in promoting/arresting the population activity. For this purpose, we consider a standard neuronal network model, with short-term synaptic plasticity, whose population activity is characterized by bursting behavior. The addition of developmentally inspired constraints and correlations in the distribution of the neuronal connectivities and excitabilities leads to the emergence of functional hub neurons, whose stimulation/deletion is critical for the network activity. Functional hubs form a clique, where a precise sequential activation of the neurons is essential to ignite collective events without any need for a specific topological architecture. Unsupervised time-lagged firings of supra-threshold cells, in connection with coordinated entrainments of near-threshold neurons, are the key ingredients to orchestrate population activity.

  4. Passivity-based control with collision avoidance for a hub-beam spacecraft

    Science.gov (United States)

    Wen, Hao; Chen, Ti; Jin, Dongping; Hu, Haiyan

    2017-01-01

    For the application of robotically assembling large space structures, a feedback control law is synthesized for transitional and rotational maneuvers of a 'tug' spacecraft in order to transport a flexible element to a desired position without colliding with other space bodies. The flexible element is treated as a long beam clamped to the 'tug' spacecraft modelled as a rigid hub. First, the physical property of passivity of Euler-Lagrange system is exploited to design the position and attitude controllers by taking a simpler obstacle-free control problem into account. To reduce sensing and actuating requirements, the vibration modes of the beam appendage are supposed to be not directly measured and actuated on. Besides, the requirements of measuring velocities are removed with the aid of a dynamic extension technique. Second, the bounding boxes in the form of super-quadric surfaces are exploited to enclose the maximal extents of the obstacles and the hub-beam spacecraft. The collision avoidance between bounding boxes is achieved by applying additional repulsive force and torque to the spacecraft based on the method of artificial potential field. Finally, the effectiveness of proposed control scheme is numerically demonstrated via case studies.

  5. Partial synchronization in networks of non-linearly coupled oscillators: The Deserter Hubs Model

    Energy Technology Data Exchange (ETDEWEB)

    Freitas, Celso, E-mail: cbnfreitas@gmail.com; Macau, Elbert, E-mail: elbert.macau@inpe.br [Associate Laboratory for Computing and Applied Mathematics - LAC, Brazilian National Institute for Space Research - INPE (Brazil); Pikovsky, Arkady, E-mail: pikovsky@uni-potsdam.de [Department of Physics and Astronomy, University of Potsdam, Germany and Department of Control Theory, Nizhni Novgorod State University, Gagarin Av. 23, 606950, Nizhni Novgorod (Russian Federation)

    2015-04-15

    We study the Deserter Hubs Model: a Kuramoto-like model of coupled identical phase oscillators on a network, where attractive and repulsive couplings are balanced dynamically due to nonlinearity of interactions. Under weak force, an oscillator tends to follow the phase of its neighbors, but if an oscillator is compelled to follow its peers by a sufficient large number of cohesive neighbors, then it actually starts to act in the opposite manner, i.e., in anti-phase with the majority. Analytic results yield that if the repulsion parameter is small enough in comparison with the degree of the maximum hub, then the full synchronization state is locally stable. Numerical experiments are performed to explore the model beyond this threshold, where the overall cohesion is lost. We report in detail partially synchronous dynamical regimes, like stationary phase-locking, multistability, periodic and chaotic states. Via statistical analysis of different network organizations like tree, scale-free, and random ones, we found a measure allowing one to predict relative abundance of partially synchronous stationary states in comparison to time-dependent ones.

  6. Current Status of Mammals and Reptiles at Hub Dam Area, Sindh / Balochistan, Pakistan

    Directory of Open Access Journals (Sweden)

    Abeda Begum

    2013-12-01

    Full Text Available During the present study in 2012, a total of twenty four mammalian species were recorded belonging to 5 orders and 10 families; out of these, 8 species are less common, 2 species are rare, while 14 species are common in Hub Dam area. Twenty five reptilian species belonging to 3 orders and 12 families were also recorded from the area. Three species of mammalian Urial (Ovis vignei, Chinkara/Indian Gazelle (Gazella bennettii and Jungle Cat (Felis chaus, one reptilian species Common Krait (Bungarus caeruleus were recorded as rare from the study area during 2012. During the present study, nine mammalian species Wild Goat/Sindh Ibex (Capra aegagrus, Urial (Ovis vignei, Chinkara/Indian Gazelle (Gazella bennettii, Indian Hedgehog (Paraechinus micropus, Cape Hare (Lepus capensis, Little Indian Field Mouse (Mus booduga, House Shrew (Sorex thibetanus, Balochistan Gerbil (Gerbillus nanus and Indian Gerbil (Tatera indica and two reptilian Warty Rock Gecko (Cyrtodactylus kachhensis kachhensis and Banded Dwarf Gecko (Tropiocolotes helenae were recorded from the area. As regards threats to mammals and reptiles, these are affected by disturbance. Efforts are being made to conserve the important mammals and reptiles particularly in the protected area especially at Hub Dam.

  7. Study on rigid-flexible coupling dynamics of hub-plate system

    Institute of Scientific and Technical Information of China (English)

    ZHAO Feiyun; XIE Yongcheng; ZHANG Ming; HE Yinbiao

    2007-01-01

    Dynamic modeling of a rotating flexible hubplate system is investigated by using Jourdain's variation principle in which the finite element method (FEM) is used as discretization method for a flexible plate. Different from the previous modeling of a plate with a prescribed large overall motion, the coupling between large overall motion of the system and elastic deformation of the flexible plate is taken into account in the proposed coupling model. The quadratic terms are included in the strain-displacement expression,such that the dynamic stiffening terms are included. Simulation of a rotating hub-plate system indicates that the linear model based on linear strain-displacement assumption may lead to erroneous results in the case of high rotation speed. Conservation of energy verifies the validity of the proposed model. Furthermore, frequency analysis of a hub-plate system shows the difference between the frequencies of the system with free and prescribed large overall motion, and parameter analysis of the system reveals the coupling characteristics of the rotational motion and the deformation.

  8. Hexcrete Tower for Harvesting Wind Energy at Taller Hub Heights - Budget Period 2

    Energy Technology Data Exchange (ETDEWEB)

    Sritharan, Sri [Iowa State Univ., Ames, IA (United States)

    2017-05-01

    Interest in designing taller towers for wind energy production in the United States (U.S.) has been steadily growing. In May 2015, it was revealed that taller towers will make wind energy production a reality in all 50 states, including some states that have nearly zero renewables in their energy portfolio. Facilitating wind energy production feasibility in all 50 states will no doubt contribute to increasing the electricity produced by wind from 4.5% in 2013 to a targeted scenario of 35% by 2050 in the Wind Vision report. This project focuses on the Hexcrete tower concept developed for tall towers using High Strength Concrete (HSC) and/or Ultra-High Performance Concrete (UHPC). Among other benefits, the Hexcrete concept overcomes transportation and logistical challenges, thus facilitating construction of towers with hub heights of 100-m (328-ft) and higher. The goal of this project is to facilitate widespread deployment of Hexcrete towers for harvesting wind energy at 120 to 140-m (394 to 459-ft) hub heights and reduce the Levelized Cost of Energy (LCOE) of wind energy production in the U.S. The technical scope of the project includes detailed design and optimization of at least three wind turbine towers using the Hexcrete concept together with experimental validation and LCOE analyses and development of a commercialization plan.

  9. Aspects of transport transit hubs construction management in coordination with object lifecycle projecting

    Directory of Open Access Journals (Sweden)

    Danilina Nina

    2016-01-01

    Full Text Available The article involves the results of the research in the field of the initial phase in the project of the object lifecycle for urban public transportation transit hubs (TTH. The main purpose is to provide definition and justification of area parameters for spatial solution of a hub with consideration of its construction viability and sustainability of urban development. In the article there are presented the results of analytical studies of the data available in the approved Planning documentation for TTH objects listed in the short-term program of TTH construction in Moscow. The point of interest was to obtain correlations between the total area of TTH area, areas of commercial and technological use and passenger traffic value in order to define territory balance providing request from city authorities and private investors for construction project management. Also, there is presented the theoretical model as an evaluation guide that allows evaluating not only the demand of a city and its population in the development of TTH territory but also and especially the requirements for placing commercial areas inside TTH.

  10. A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans.

    Science.gov (United States)

    Macosko, Evan Z; Pokala, Navin; Feinberg, Evan H; Chalasani, Sreekanth H; Butcher, Rebecca A; Clardy, Jon; Bargmann, Cornelia I

    2009-04-30

    Innate social behaviours emerge from neuronal circuits that interpret sensory information on the basis of an individual's own genotype, sex and experience. The regulated aggregation behaviour of the nematode Caenorhabditis elegans, a simple animal with only 302 neurons, is an attractive system to analyse these circuits. Wild social strains of C. elegans aggregate in the presence of specific sensory cues, but solitary strains do not. Here we identify the RMG inter/motor neuron as the hub of a regulated circuit that controls aggregation and related behaviours. RMG is the central site of action of the neuropeptide receptor gene npr-1, which distinguishes solitary strains (high npr-1 activity) from wild social strains (low npr-1 activity); high RMG activity is essential for all aspects of social behaviour. Anatomical gap junctions connect RMG to several classes of sensory neurons known to promote aggregation, and to ASK sensory neurons, which are implicated in male attraction to hermaphrodite pheromones. We find that ASK neurons respond directly to pheromones, and that high RMG activity enhances ASK responses in social strains, causing hermaphrodite attraction to pheromones at concentrations that repel solitary hermaphrodites. The coordination of social behaviours by RMG suggests an anatomical hub-and-spoke model for sensory integration in aggregation, and points to functions for related circuit motifs in the C. elegans wiring diagram.

  11. Characteristics and concepts of dynamic hub proteins in DNA processing machinery from studies of RPA.

    Science.gov (United States)

    Sugitani, Norie; Chazin, Walter J

    2015-03-01

    DNA replication, damage response and repair require the coordinated action of multi-domain proteins operating within dynamic multi-protein machines that act upon the DNA substrate. These modular proteins contain flexible linkers of various lengths, which enable changes in the spatial distribution of the globular domains (architecture) that harbor their essential biochemical functions. This mobile architecture is uniquely suited to follow the evolving substrate landscape present over the course of the specific process performed by the multi-protein machinery. A fundamental advance in understanding of protein machinery is the realization of the pervasive role of dynamics. Not only is the machine undergoing dynamic transformations, but the proteins themselves are flexible and constantly adapting to the progression through the steps of the overall process. Within this dynamic context the activity of the constituent proteins must be coordinated, a role typically played by hub proteins. A number of important characteristics of modular proteins and concepts about the operation of dynamic machinery have been discerned. These provide the underlying basis for the action of the machinery that reads DNA, and responds to and repairs DNA damage. Here, we introduce a number of key characteristics and concepts, including the modularity of the proteins, linkage of weak binding sites, direct competition between sites, and allostery, using the well recognized hub protein replication protein A (RPA).

  12. DIGITAL VIDEO BROADCAST RETURN CHANNEL VIA SATELLITE (DVB-RCS HUB FOR SATELLITE BASED E-LEARNING

    Directory of Open Access Journals (Sweden)

    N.G.Vasantha Kumar

    2011-02-01

    Full Text Available This paper discusses in-house designed and developed scale-down DVB-RCS hub along with the performance of the realized hub. This development is intended to support the Satellite Based e-Learning initiative in India. The scale-down DVB-RCS HUB is implemented around a single PC with other subsystems making it very cost effective and unique of its kind. This realization will drastically reduce the total cost of Satellite based Education Networks as very low cost commercially available Satellite Interactive Terminals (SITs complying to open standard could be used at remote locations. The system is successfully tested to work with a commercial SIT using a GEO satellite EDUSAT which is especially dedicated for satellite based e-Learning. The internal detail of the DVB-RCS Forward and Return Link Organization and how it manages the Satellite Interactive Terminals access to the satellite channel using MF-TDMA approach has been described.

  13. Topology and Non-Deterministic Polynomial Time Computation : Avoidance of The Misbehaviour of Hub-Free Diagrams and Consequences

    Directory of Open Access Journals (Sweden)

    Anthony Gasperin

    2013-09-01

    Full Text Available To study groups with small Dehn's function, Olshanskii and Sapir developed a new invariant of bipartite chords diagrams and applied it to hub-free realization of S-machines. In this paper we consider this new invariant together with groups constructed from S-machines containing the hub relation. The idea is to study the links between the topology of the asymptotic cones and polynomial time computations. Indeed it is known that the topology of such metric space depends on diagrams without hubs that do not correspond to the computations of the considered S-machine. This work gives sufficient conditions that avoid this misbehaviour, but as we shall see the method has a significant drawback.

  14. WHAT IS CONTROLLING THE FRAGMENTATION IN THE INFRARED DARK CLOUD G14.225–0.506?: DIFFERENT LEVELS OF FRAGMENTATION IN TWIN HUBS

    Energy Technology Data Exchange (ETDEWEB)

    Busquet, Gemma; Girart, Josep Miquel [Institut de Ciències de l’Espai (CSIC-IEEC), Campus UAB, Carrer de Can Magrans, S/N, E-08193, Cerdanyola del Vallès, Catalunya (Spain); Estalella, Robert [Departament d’Astronomia i Meteorologia, Institut de Ciències del Cosmos (ICC), Universitat de Barcelona (IEEC-UB), Martí i Franquès, 1, E-08028 Barcelona, Catalunya (Spain); Palau, Aina [Instituto de Radioastronomía y Astrofísica, Universidad Nacional Autónoma de México, P.O. Box 3-72, 58090 Morelia, Michoacán, México (Mexico); Liu, Hauyu Baobab; Ho, Paul T. P. [Academia Sinica Institute of Astronomy and Astrophysics, Taipei, Taiwan (China); Zhang, Qizhou [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); De Gregorio-Monsalvo, Itziar [European Southern Observatory (ESO), Karl-Schwarzschild-Str. 2, D-85748 Garching (Germany); Pillai, Thushara [Max Planck Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Anglada, Guillem, E-mail: busquet@ice.cat [Instituto de Astrofísica de Andalucía, CSIC, Glorieta de la Astronomía, s/n, E-18008, Granada (Spain)

    2016-03-20

    We present observations of the 1.3 mm continuum emission toward hub-N and hub-S of the infrared dark cloud G14.225–0.506 carried out with the Submillimeter Array, together with observations of the dust emission at 870 and 350 μm obtained with APEX and CSO telescopes. The large-scale dust emission of both hubs consists of a single peaked clump elongated in the direction of the associated filament. At small scales, the SMA images reveal that both hubs fragment into several dust condensations. The fragmentation level was assessed under the same conditions and we found that hub-N presents 4 fragments while hub-S is more fragmented, with 13 fragments identified. We studied the density structure by means of a simultaneous fit of the radial intensity profile at 870 and 350 μm and the spectral energy distribution adopting a Plummer-like function to describe the density structure. The parameters inferred from the model are remarkably similar in both hubs, suggesting that density structure could not be responsible for determining the fragmentation level. We estimated several physical parameters, such as the level of turbulence and the magnetic field strength, and we found no significant differences between these hubs. The Jeans analysis indicates that the observed fragmentation is more consistent with thermal Jeans fragmentation compared with a scenario in which turbulent support is included. The lower fragmentation level observed in hub-N could be explained in terms of stronger UV radiation effects from a nearby H ii region, evolutionary effects, and/or stronger magnetic fields at small scales, a scenario that should be further investigated.

  15. 旅游枢纽理论与实践研究综述%A systematic literature review of tourism hub theory and practice

    Institute of Scientific and Technical Information of China (English)

    邹统钎; 江璐虹; 郭晓霞

    2016-01-01

    Research on tourism hubs in China and abroad are based on transportation hubs,after which the basic theory about tourism hubs occurred and boosted study on the theoretical and practical development of tourism hubs.Tourism hubs originated from transportation hubs.Based on transportation hubs,tourism hubs provide tourists with tourism-related information,service and infrastructure,as well as well-rounded,seamless and accessible integration of all kind of transports which make tourist transfers and travel more convenient.Tourism hubs bridge tourism markets and destinations,but there are differences between them.The tourism resources are main attractions for tourists while tourism hubs strike to control the local tourism industry through tourist flows.The functions of gathering and scattering are key factors for tourism hubs which help to control tourist flows and the tourism industry.According to different practical functions and various development processes of international tourism hubs,we generalize their practices and divide them into two categories:hub-dominated tourism cities and hub-destination tourism cities.The development of international tourism hubs follows similar laws.Well-constructed hubs,especially the airport hub network will be helpful for tourism hubs to attract tourist flow.Tourism hubs benefit from their hub functions and control of local tourism industries.With the development of the tourism industry,tourist destinations and tourism hubs tend to mix together.%旅游枢纽的国内外研究经历了“交通枢纽-旅游枢纽基础理论-旅游枢纽”的阶段演变.旅游枢纽的发展源于交通枢纽,以交通枢纽为基础,以人的运输为主,提供旅游配套的信息服务,并整合了一般公共交通等多种交通方式,为游客提供便捷服务.旅游枢纽是旅游客源地与目的地之间的中介与桥梁,旅游目的地主要通过拥有的旅游资源形成吸引物,旅游枢纽则通过流经

  16. Why primary care practices should become digital health information hubs for their patients.

    Science.gov (United States)

    Baird, Aaron; Nowak, Samantha

    2014-11-25

    Two interesting health care trends are currently occurring: 1) patient-facing technologies, such as personal health records, patient portals, and mobile health apps, are being adopted at rapid rates, and 2) primary care, which includes family practice, is being promoted as essential to reducing health care costs and improving health care outcomes. While these trends are notable and commendable, both remain subject to significant fragmentation and incentive misalignments, which has resulted in significant data coordination and value generation challenges. In particular, patient-facing technologies designed to increase care coordination, often fall prey to the very digital fragmentation issues they are supposed to overcome. Additionally, primary care providers are treating patients that may have considerable health information histories, but generating a single view of such multi-source data is nearly impossible. We contribute to this debate by proposing that primary care practices become digital health information hubs for their patients. Such hubs would offer health data coordination in a medically professional setting with the benefits of expert, trustworthy advice coupled with active patient engagement. We acknowledge challenges including: costs, information quality and provenance, willingness-to-share information and records, willingness-to-use (by both providers and patients), primary care scope creep, and determinations of technical and process effectiveness. Even with such potential challenges, we strongly believe that more debate is needed on this topic prior to full implementation of various health information technology incentives and reform programs currently being designed and enacted throughout the world. Ultimately, if we do not provide a meaningful way for the full spectrum of health information to be used by both providers and patients, especially early in the health care continuum, effectively improving health outcomes may remain elusive. We view

  17. Comparative Genomic Analysis Reveals Habitat-Specific Genes and Regulatory Hubs within the Genus Novosphingobium

    Science.gov (United States)

    Kumar, Roshan; Verma, Helianthous; Haider, Shazia; Bajaj, Abhay; Sood, Utkarsh; Ponnusamy, Kalaiarasan; Nagar, Shekhar; Shakarad, Mallikarjun N.; Negi, Ram Krishan; Singh, Yogendra; Khurana, J. P.; Gilbert, Jack A.

    2017-01-01

    ABSTRACT Species belonging to the genus Novosphingobium are found in many different habitats and have been identified as metabolically versatile. Through comparative genomic analysis, we identified habitat-specific genes and regulatory hubs that could determine habitat selection for Novosphingobium spp. Genomes from 27 Novosphingobium strains isolated from diverse habitats such as rhizosphere soil, plant surfaces, heavily contaminated soils, and marine and freshwater environments were analyzed. Genome size and coding potential were widely variable, differing significantly between habitats. Phylogenetic relationships between strains were less likely to describe functional genotype similarity than the habitat from which they were isolated. In this study, strains (19 out of 27) with a recorded habitat of isolation, and at least 3 representative strains per habitat, comprised four ecological groups—rhizosphere, contaminated soil, marine, and freshwater. Sulfur acquisition and metabolism were the only core genomic traits to differ significantly in proportion between these ecological groups; for example, alkane sulfonate (ssuABCD) assimilation was found exclusively in all of the rhizospheric isolates. When we examined osmolytic regulation in Novosphingobium spp. through ectoine biosynthesis, which was assumed to be marine habitat specific, we found that it was also present in isolates from contaminated soil, suggesting its relevance beyond the marine system. Novosphingobium strains were also found to harbor a wide variety of mono- and dioxygenases, responsible for the metabolism of several aromatic compounds, suggesting their potential to act as degraders of a variety of xenobiotic compounds. Protein-protein interaction analysis revealed β-barrel outer membrane proteins as habitat-specific hubs in each of the four habitats—freshwater (Saro_1868), marine water (PP1Y_AT17644), rhizosphere (PMI02_00367), and soil (V474_17210). These outer membrane proteins could play a

  18. Comparative Genomic Analysis Reveals Habitat-Specific Genes and Regulatory Hubs within the Genus Novosphingobium.

    Science.gov (United States)

    Kumar, Roshan; Verma, Helianthous; Haider, Shazia; Bajaj, Abhay; Sood, Utkarsh; Ponnusamy, Kalaiarasan; Nagar, Shekhar; Shakarad, Mallikarjun N; Negi, Ram Krishan; Singh, Yogendra; Khurana, J P; Gilbert, Jack A; Lal, Rup

    2017-01-01

    Species belonging to the genus Novosphingobium are found in many different habitats and have been identified as metabolically versatile. Through comparative genomic analysis, we identified habitat-specific genes and regulatory hubs that could determine habitat selection for Novosphingobium spp. Genomes from 27 Novosphingobium strains isolated from diverse habitats such as rhizosphere soil, plant surfaces, heavily contaminated soils, and marine and freshwater environments were analyzed. Genome size and coding potential were widely variable, differing significantly between habitats. Phylogenetic relationships between strains were less likely to describe functional genotype similarity than the habitat from which they were isolated. In this study, strains (19 out of 27) with a recorded habitat of isolation, and at least 3 representative strains per habitat, comprised four ecological groups-rhizosphere, contaminated soil, marine, and freshwater. Sulfur acquisition and metabolism were the only core genomic traits to differ significantly in proportion between these ecological groups; for example, alkane sulfonate (ssuABCD) assimilation was found exclusively in all of the rhizospheric isolates. When we examined osmolytic regulation in Novosphingobium spp. through ectoine biosynthesis, which was assumed to be marine habitat specific, we found that it was also present in isolates from contaminated soil, suggesting its relevance beyond the marine system. Novosphingobium strains were also found to harbor a wide variety of mono- and dioxygenases, responsible for the metabolism of several aromatic compounds, suggesting their potential to act as degraders of a variety of xenobiotic compounds. Protein-protein interaction analysis revealed β-barrel outer membrane proteins as habitat-specific hubs in each of the four habitats-freshwater (Saro_1868), marine water (PP1Y_AT17644), rhizosphere (PMI02_00367), and soil (V474_17210). These outer membrane proteins could play a key role in

  19. A Futile Search for Values and Pedagogy? A Discursive Analysis of the Marketing Messages of Branch-Campuses in Higher Education Hubs

    Science.gov (United States)

    Karram, Grace

    2014-01-01

    Higher education has become a key strategy for the economic development of certain city-states that are positioning themselves as higher education hubs, recruiting both students and foreign providers. This article presents the findings of a research study that examined the online messages of foreign branch-campuses in education hubs (Dubai, Hong…

  20. Global trade & the Dutch hub: understanding variegated forms of embeddedness of international trade in the Netherlands: clothing, flowers, and high-tech products

    NARCIS (Netherlands)

    Levelt, M.

    2010-01-01

    As global trade increases, some regions have become specialized in international trade and logistics, forming hubs to larger market areas. Although a lot is known about international trade in quantitative terms, much less is known about actual trade activities taking place in trade hubs and the ways

  1. Global trade & the Dutch hub: understanding variegated forms of embeddedness of international trade in the Netherlands: clothing, flowers, and high-tech products

    NARCIS (Netherlands)

    Levelt, M.

    2010-01-01

    As global trade increases, some regions have become specialized in international trade and logistics, forming hubs to larger market areas. Although a lot is known about international trade in quantitative terms, much less is known about actual trade activities taking place in trade hubs and the ways

  2. Participant Adherence Indicators Predict Changes in Blood Pressure, Anthropometric Measures, and Self-Reported Physical Activity in a Lifestyle Intervention: HUB City Steps

    Science.gov (United States)

    Thomson, Jessica L.; Landry, Alicia S.; Zoellner, Jamie M.; Connell, Carol; Madson, Michael B.; Molaison, Elaine Fontenot; Yadrick, Kathy

    2015-01-01

    The objective of this secondary analysis was to evaluate the utility of several participant adherence indicators for predicting changes in clinical, anthropometric, dietary, fitness, and physical activity (PA) outcomes in a lifestyle intervention, HUB City Steps, conducted in a southern, African American cohort in 2010. HUB City Steps was a…

  3. Creating a global rare disease patient registry linked to a rare diseases biorepository database: Rare Disease-HUB (RD-HUB).

    Science.gov (United States)

    Rubinstein, Yaffa R; Groft, Stephen C; Bartek, Ronald; Brown, Kyle; Christensen, Ronald A; Collier, Elaine; Farber, Amy; Farmer, Jennifer; Ferguson, John H; Forrest, Christopher B; Lockhart, Nicole C; McCurdy, Kate R; Moore, Helen; Pollen, Geraldine B; Richesson, Rachel; Miller, Vanessa Rangel; Hull, Sara; Vaught, Jim

    2010-09-01

    A movement to create a global patient registry for as many as 7,000 rare diseases was launched at a workshop, "Advancing Rare Disease Research: The Intersection of Patient Registries, Biospecimen Repositories, and Clinical Data." http://rarediseases.info.nih.gov/PATIENT_REGISTRIES_WORKSHOP/. The workshop was sponsored by the Office of Rare Diseases Research (ORDR). The focus was the building of an infrastructure for an internet-based global registry linking to biorepositories. Such a registry would serve the patients, investigators, and drug companies. To aid researchers the participants suggested the creation of a centralized database of biorepositories for rare biospecimens (RD-HUB)http://biospecimens.ordr.info.nih.gov/ that could be linked to the registry. Over two days of presentations and breakout sessions, several hundred attendees discussed government rules and regulations concerning privacy and patients' rights and the nature and scope of data to be entered into a central registry as well as concerns about how to validate patient and clinician-entered data to ensure data accuracy. Mechanisms for aggregating data from existing registries were also discussed. The attendees identified registry best practices, model coding systems, international systems for recruiting patients into clinical trials and novel ways of using the internet directly to invite participation in research. They also speculated about who would bear ultimate responsibility for the informatics in the registry and who would have access to the information. Hurdles associated with biospecimen collection and how to overcome them were detailed. The development of the recommendations was, in itself, an indication of the commitment of the rare disease community as never before.

  4. A New Dynamic Model for a Flexible Hub-Beam System

    Institute of Scientific and Technical Information of China (English)

    LIU Zhu-yong; HONG Jia-zhen; CAI Guo-ping

    2009-01-01

    In this paper, a new dynamic model for the flexible hub-beam system is proposed by using the principle of continuum medium mechanics and the finite element discretization method. In the proposed model, the coupling deformation of any element of the beam is only related with the nodal coordinates of this element. So this model is suitable to the rotating beam in an arbitrary shape. Numerical examples of slender beams in straight and irregular shapes are carried out to demonstrate the validation of the proposed model. Simulation results indicate that the proposed model can be used valid for dynamic description of flexible rotating beam in irregular shape, and for both low and high rotation speeds.

  5. The UK National Quantum Technologies Hub in sensors and metrology (Keynote Paper)

    Science.gov (United States)

    Bongs, K.; Boyer, V.; Cruise, M. A.; Freise, A.; Holynski, M.; Hughes, J.; Kaushik, A.; Lien, Y.-H.; Niggebaum, A.; Perea-Ortiz, M.; Petrov, P.; Plant, S.; Singh, Y.; Stabrawa, A.; Paul, D. J.; Sorel, M.; Cumming, D. R. S.; Marsh, J. H.; Bowtell, R. W.; Bason, M. G.; Beardsley, R. P.; Campion, R. P.; Brookes, M. J.; Fernholz, T.; Fromhold, T. M.; Hackermuller, L.; Krüger, P.; Li, X.; Maclean, J. O.; Mellor, C. J.; Novikov, S. V.; Orucevic, F.; Rushforth, A. W.; Welch, N.; Benson, T. M.; Wildman, R. D.; Freegarde, T.; Himsworth, M.; Ruostekoski, J.; Smith, P.; Tropper, A.; Griffin, P. F.; Arnold, A. S.; Riis, E.; Hastie, J. E.; Paboeuf, D.; Parrotta, D. C.; Garraway, B. M.; Pasquazi, A.; Peccianti, M.; Hensinger, W.; Potter, E.; Nizamani, A. H.; Bostock, H.; Rodriguez Blanco, A.; Sinuco-Leon, G.; Hill, I. R.; Williams, R. A.; Gill, P.; Hempler, N.; Malcolm, G. P. A.; Cross, T.; Kock, B. O.; Maddox, S.; John, P.

    2016-04-01

    The UK National Quantum Technology Hub in Sensors and Metrology is one of four flagship initiatives in the UK National of Quantum Technology Program. As part of a 20-year vision it translates laboratory demonstrations to deployable practical devices, with game-changing miniaturized components and prototypes that transform the state-of-the-art for quantum sensors and metrology. It brings together experts from the Universities of Birmingham, Glasgow, Nottingham, Southampton, Strathclyde and Sussex, NPL and currently links to over 15 leading international academic institutions and over 70 companies to build the supply chains and routes to market needed to bring 10-1000x improvements in sensing applications. It seeks, and is open to, additional partners for new application development and creates a point of easy open access to the facilities and supply chains that it stimulates or nurtures.

  6. Plasma membrane domains enriched in cortical endoplasmic reticulum function as membrane protein trafficking hubs.

    Science.gov (United States)

    Fox, Philip D; Haberkorn, Christopher J; Weigel, Aubrey V; Higgins, Jenny L; Akin, Elizabeth J; Kennedy, Matthew J; Krapf, Diego; Tamkun, Michael M

    2013-09-01

    In mammalian cells, the cortical endoplasmic reticulum (cER) is a network of tubules and cisterns that lie in close apposition to the plasma membrane (PM). We provide evidence that PM domains enriched in underlying cER function as trafficking hubs for insertion and removal of PM proteins in HEK 293 cells. By simultaneously visualizing cER and various transmembrane protein cargoes with total internal reflectance fluorescence microscopy, we demonstrate that the majority of exocytotic delivery events for a recycled membrane protein or for a membrane protein being delivered to the PM for the first time occur at regions enriched in cER. Likewise, we observed recurring clathrin clusters and functional endocytosis of PM proteins preferentially at the cER-enriched regions. Thus the cER network serves to organize the molecular machinery for both insertion and removal of cell surface proteins, highlighting a novel role for these unique cellular microdomains in membrane trafficking.

  7. Southern African Office of Astronomy for Development: A New Hub for Astronomy for Development

    Science.gov (United States)

    Mutondo, Moola S.; Simpemba, Prospery

    2016-10-01

    A new Astronomy for Development hub needs innovative tools and programs. SAROAD is developing exciting tools integrating Raspberry Pi technology to bring cost-effective astronomy content to learning centres. SAROAD would also like to report achievements in realizing the IAU's strategic plan. In order to manage, evaluate and coordinate regional IAU (International Astronomical Union) capacity building programmes, including the recruitment and mobilization of volunteers, SAROAD has built an intranet that is accessible to regional members upon request. Using this resource, regional members can see and participate in regional activities. SAROAD has commenced with projects in the three Task Force areas of Universities and Research, Children and Schools and Public Outreach. Under the three Task Force areas, a total of seven projects have commenced in Zambia (some supported by funds from IAU Annual Call for proposals).

  8. The Development of Jomo Kenyatta International Airport as a Regional Aviation Hub

    Science.gov (United States)

    Irandu, Evaristus M.; Rhoades, Dawna L.

    2006-01-01

    Air transportation plays an important role in the social and economic development of the global system and the countries that seek to participate in it. As Africa seeks to take its place in the global economy, it is increasingly looking to aviation as the primary means of connecting its people and goods with the world. It has been suggested that Africa as a continent needs to move toward a system of hubs to optimize its scarce resources. Jomo Kenyatta International Airport in Nairobi, Kenya, is one of the airports in the eastern region of Africa that is seeking to fill this role. This paper discusses the prospects for success and the challenges that it will need to overcome, including projections through 2020 for the growth in passenger and cargo traffic.

  9. Membrane contact sites, ancient and central hubs of cellular lipid logistics.

    Science.gov (United States)

    Jain, Amrita; Holthuis, Joost C M

    2017-09-01

    Membrane contact sites (MCSs) are regions where two organelles are closely apposed to facilitate molecular communication and promote a functional integration of compartmentalized cellular processes. There is growing evidence that MCSs play key roles in controlling intracellular lipid flows and distributions. Strikingly, even organelles connected by vesicular trafficking exchange lipids en bulk via lipid transfer proteins that operate at MCSs. Herein, we describe how MCSs developed into central hubs of lipid logistics during the evolution of eukaryotic cells. We then focus on how modern eukaryotes exploit MCSs to help solve a major logistical problem, namely to preserve the unique lipid mixtures of their early and late secretory organelles in the face of extensive vesicular trafficking. This article is part of a Special Issue entitled: Membrane Contact Sites edited by Christian Ungermann and Benoit Kornmann. Copyright © 2017. Published by Elsevier B.V.

  10. MNCS' PERCEPTION ON THE FEASIBILITY OF SOUTH KOREA AS A BUSINESS HUB OF NORTHEAST ASIA

    Directory of Open Access Journals (Sweden)

    You-Il Lee

    2004-01-01

    Full Text Available Since the financial crisis of 1997, the South Korean government has moved towards a new market-driven paradigm of economic growth based on foreign direct investment (FDI replacing the decades old state-driven economic growth model. One of the attempts made by the government is its ambition to transform the nation into a business and economic hub of Northeast Asia. However, despite the growing concern on the topic among government agencies, media, research centers and academia, the absence of a cohesive and realistic approach to the issue is a relative void in the literature. This paper, which is based on findings from interviews with foreign companies operating in Korea during 2002, offers a cultural and institutional insight into the critical and often invisible issues to be considered for a successful realization of the vision.

  11. On the interconnection of stable protein complexes: inter-complex hubs and their conservation in Saccharomyces cerevisiae and Homo sapiens networks.

    Science.gov (United States)

    Guerra, Concettina

    2015-01-01

    Protein complexes are key molecular entities that perform a variety of essential cellular functions. The connectivity of proteins within a complex has been widely investigated with both experimental and computational techniques. We developed a computational approach to identify and characterise proteins that play a role in interconnecting complexes. We computed a measure of inter-complex centrality, the crossroad index, based on disjoint paths connecting proteins in distinct complexes and identified inter-complex hubs as proteins with a high value of the crossroad index. We applied the approach to a set of stable complexes in Saccharomyces cerevisiae and in Homo sapiens. Just as done for hubs, we evaluated the topological and biological properties of inter-complex hubs addressing the following questions. Do inter-complex hubs tend to be evolutionary conserved? What is the relation between crossroad index and essentiality? We found a good correlation between inter-complex hubs and both evolutionary conservation and essentiality.

  12. A unique four-hub protein cluster associates to glioblastoma progression.

    Directory of Open Access Journals (Sweden)

    Pasquale Simeone

    Full Text Available Gliomas are the most frequent brain tumors. Among them, glioblastomas are malignant and largely resistant to available treatments. Histopathology is the gold standard for classification and grading of brain tumors. However, brain tumor heterogeneity is remarkable and histopathology procedures for glioma classification remain unsatisfactory for predicting disease course as well as response to treatment. Proteins that tightly associate with cancer differentiation and progression, can bear important prognostic information. Here, we describe the identification of protein clusters differentially expressed in high-grade versus low-grade gliomas. Tissue samples from 25 high-grade tumors, 10 low-grade tumors and 5 normal brain cortices were analyzed by 2D-PAGE and proteomic profiling by mass spectrometry. This led to identify 48 differentially expressed protein markers between tumors and normal samples. Protein clustering by multivariate analyses (PCA and PLS-DA provided discrimination between pathological samples to an unprecedented extent, and revealed a unique network of deranged proteins. We discovered a novel glioblastoma control module centered on four major network hubs: Huntingtin, HNF4α, c-Myc and 14-3-3ζ. Immunohistochemistry, western blotting and unbiased proteome-wide meta-analysis revealed altered expression of this glioblastoma control module in human glioma samples as compared with normal controls. Moreover, the four-hub network was found to cross-talk with both p53 and EGFR pathways. In summary, the findings of this study indicate the existence of a unifying signaling module controlling glioblastoma pathogenesis and malignant progression, and suggest novel targets for development of diagnostic and therapeutic procedures.

  13. Southern Africa Regional Office of Astronomy for Development: A New Hub for Astronomy for Development

    Science.gov (United States)

    Siseho Mutondo, Moola

    2015-08-01

    A new Astronomy for Development hub needs innovative tools and programs. SAROAD is developing exciting tools integrating Raspberry Pi® technology to bring cost-effective astronomy content to learning centres. SAROAD would also like to report achievements in realising the IAU's strategic plan. In order to manage, evaluate and coordinate regional IAU capacity building programmes, including the recruitment and mobilisation of volunteers, SAROAD has built an intranet that is accessible to regional members upon request. Using this resource, regional members can see and participate in regional activities. This resource also forms the foundation for closer collaboration between SAROAD member countries. SAROAD has commenced with projects in the three Task Force areas of Universities and Research, Children and Schools and Public Outreach. Under the three Task Force areas, a total of seven projects have commenced in Zambia. A further two projects involve the collaboration of Zambia and other regional member countries in order to foster engagement with important regional astronomy facilities (e.g. SKA). SAROAD has identified the IAU’s International Year of Light and a starting point for offering regional support for IAU-endorsed global activities. SAROAD has set up a hub dedicated to regional events and activities about the International Year of Light. SAROAD has a database of regional authorities to enable contact with the region's decision makers and experts. SAROAD will hold an annual event which brings forum for astronomy for development. The creation of the database and the SAROAD Road show is a first step towards this goal. The SAROAD website has helped to advertise upcoming events for astronomy development and education; it is used to provide advice, guidance and information for astronomers in all countries in the Southern Africa. Fundraising is the primary goal for SAROAD in 2015 towards financial self-sufficiency by 2020. We report on the methods that work best

  14. CFTR: a hub for kinases and crosstalk of cAMP and Ca2+.

    Science.gov (United States)

    Kunzelmann, Karl; Mehta, Anil

    2013-09-01

    Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR). The resulting disease is pleiotropic consistent with the idea that CFTR acts as a node within a network of signalling proteins. CFTR is not only a regulator of multiple transport proteins and controlled by numerous kinases but also participates in many signalling pathways that are disrupted after expression of its commonest mutant (F508del-CFTR). It operates in membrane compartments creating a scaffold for cytoskeletal elements, surface receptors, kinases and phosphodiesterases. CFTR is exposed to membrane-local second messengers such that a CFTR-interacting, low cellular energy sensor kinase (AMP- and ADP-activated kinase, AMPK) signals through a high energy phosphohistidine protein kinase (nucleoside diphosphate kinase, NDPK). CFTR also translocates a Ca(2+)-dependent adenylate cyclase to its proximity so that a rigid separation between cAMP-dependent and Ca(2+)-dependent regulation of Cl(-) transport becomes obsolete. In the presence of wild-type CFTR, parallel activation of CFTR and outwardly rectifying anoctamin 6 Cl(-) channels is observed, while the Ca(2+)-activated anoctamin 1 Cl(-) channel is inhibited. In contrast, in CF cells, CFTR is missing/mislocalized and the outwardly rectifying chloride channel is attenuated while Ca(2+)-dependent Cl(-) secretion (anoctamin 1) appears upregulated. Additionally, we consider the idea that F508del-CFTR when trapped in the endoplasmic reticulum augments IP3-mediated Ca(2+) release by providing a shunt pathway for Cl(-). CFTR and the IP3 receptor share the characteristic that they both assemble their partner proteins to increase the plasticity of their hub responses. In CF, the CFTR hub fails to form at the plasma membrane, with widespread detrimental consequences for cell signalling.

  15. White Matter Disruptions in Schizophrenia Are Spatially Widespread and Topologically Converge on Brain Network Hubs.

    Science.gov (United States)

    Klauser, Paul; Baker, Simon T; Cropley, Vanessa L; Bousman, Chad; Fornito, Alex; Cocchi, Luca; Fullerton, Janice M; Rasser, Paul; Schall, Ulrich; Henskens, Frans; Michie, Patricia T; Loughland, Carmel; Catts, Stanley V; Mowry, Bryan; Weickert, Thomas W; Shannon Weickert, Cynthia; Carr, Vaughan; Lenroot, Rhoshel; Pantelis, Christos; Zalesky, Andrew

    2017-03-01

    White matter abnormalities associated with schizophrenia have been widely reported, although the consistency of findings across studies is moderate. In this study, neuroimaging was used to investigate white matter pathology and its impact on whole-brain white matter connectivity in one of the largest samples of patients with schizophrenia. Fractional anisotropy (FA) and mean diffusivity (MD) were compared between patients with schizophrenia or schizoaffective disorder (n = 326) and age-matched healthy controls (n = 197). Between-group differences in FA and MD were assessed using voxel-based analysis and permutation testing. Automated whole-brain white matter fiber tracking and the network-based statistic were used to characterize the impact of white matter pathology on the connectome and its rich club. Significant reductions in FA associated with schizophrenia were widespread, encompassing more than 40% (234ml) of cerebral white matter by volume and involving all cerebral lobes. Significant increases in MD were also widespread and distributed similarly. The corpus callosum, cingulum, and thalamic radiations exhibited the most extensive pathology according to effect size. More than 50% of cortico-cortical and cortico-subcortical white matter fiber bundles comprising the connectome were disrupted in schizophrenia. Connections between hub regions comprising the rich club were disproportionately affected. Pathology did not differ between patients with schizophrenia and schizoaffective disorder and was not mediated by medication. In conclusion, although connectivity between cerebral hubs is most extensively disturbed in schizophrenia, white matter pathology is widespread, affecting all cerebral lobes and the cerebellum, leading to disruptions in the majority of the brain's fiber bundles. © The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  16. Hubs of Anticorrelation in High-Resolution Resting-State Functional Connectivity Network Architecture.

    Science.gov (United States)

    Gopinath, Kaundinya; Krishnamurthy, Venkatagiri; Cabanban, Romeo; Crosson, Bruce A

    2015-06-01

    A major focus of brain research recently has been to map the resting-state functional connectivity (rsFC) network architecture of the normal brain and pathology through functional magnetic resonance imaging. However, the phenomenon of anticorrelations in resting-state signals between different brain regions has not been adequately examined. The preponderance of studies on resting-state fMRI (rsFMRI) have either ignored anticorrelations in rsFC networks or adopted methods in data analysis, which have rendered anticorrelations in rsFC networks uninterpretable. The few studies that have examined anticorrelations in rsFC networks using conventional methods have found anticorrelations to be weak in strength and not very reproducible across subjects. Anticorrelations in rsFC network architecture could reflect mechanisms that subserve a number of important brain processes. In this preliminary study, we examined the properties of anticorrelated rsFC networks by systematically focusing on negative cross-correlation coefficients (CCs) among rsFMRI voxel time series across the brain with graph theory-based network analysis. A number of methods were implemented to enhance the neuronal specificity of resting-state functional connections that yield negative CCs, although at the cost of decreased sensitivity. Hubs of anticorrelation were seen in a number of cortical and subcortical brain regions. Examination of the anticorrelation maps of these hubs indicated that negative CCs in rsFC network architecture highlight a number of regulatory interactions between brain networks and regions, including reciprocal modulations, suppression, inhibition, and neurofeedback.

  17. Differential evolution algorithm for multi-commodity and multi-level of service hub covering location problem

    Directory of Open Access Journals (Sweden)

    M. Setak

    2013-01-01

    Full Text Available The hub location problem involves a network of origins and destinations over which transportation takes place. There are many studies associated with finding the location of hub nodes and the allocation of demand nodes to these located hub nodes to transfer the only one kind of commodity under one level of service. However, in this study, carrying different commodity types from origin to destination under various levels of services (e.g. price, punctuality, reliability or transit time is studied. Quality of services experienced by users such as speed, convenience, comfort and security of transportation facilities and services is considered as the level of service. In each system, different kinds of commodities with various levels of services can be transmitted. The appropriate level of service that a commodity can be transmitted through is chosen by customer preferences and the specification of the commodity. So, a mixed integer programming formulation for single allocation hub covering location problem, which is based on the idea of transferring multi commodity flows under multi levels of service is presented. These two are applied concepts, multi-commodity and multi-level of service, which make the model's assumptions closer to the real world problems. In addition, a differential evolution algorithm is designed to find near-optimal solutions. The obtained solutions using differential evolution (DE algorithm (upper bound, where its parameters are tuned by response surface methodology, are compared with exact solutions and computed lower bounds by linear relaxation technique to prove the efficiency of proposed DE algorithm.

  18. Air network performance and hub competitive position: evaluation of primary airports in East and South-East Asia

    NARCIS (Netherlands)

    G. Burghouwt; J. de Wit; J. Veldhuis; H. Matsumoto

    2009-01-01

    The growth of hub-and-spoke operations has changed the structure of competition among airlines and airports, meaning that airlines now compete both directly (air services from A to B) as well as indirectly (services from A to B via H). Traditional measures of airport performance, such as passenger e

  19. Joint Optimization of Star P-hub Median Problem and Seat Inventory Control Decisions Considering a Hybrid Routing Transportation System

    Directory of Open Access Journals (Sweden)

    Hamid Tikani

    2016-11-01

    Full Text Available In this paper, we study the problem of integrated capacitated hub location problem and seat inventory control considering concept and techniques of revenue management. We consider an airline company maximizes its revenue by utilizing the best network topology and providing proper booking limits for all itineraries and fare classes. The transportation system arises in the form of a star/star network and includes both hub-stop and non-stop flights. This problem is formulated as a two-stage stochastic integer program with mixed-integer recourse. We solve various instances carried out from the Turkish network data set. Due to the NP-hardness of the problem, we propose a hybrid optimization method, consisting of an evolutionary algorithm based on genetic algorithm and exact solution. The quality of the solutions found by the proposed meta-heuristic is compared with the original version of GA and the mathematical programming model. The results obtained by the proposed model imply that integrating hub location and seat inventory control problem would help to increase the total revenue of airline companies. Also, in the case of serving non-stop flights, the model can provide more profit by employing less number of hubs.

  20. Optimization of Hybrid Hub-and-Spoke Network Operation for Less-Than-Truckload Freight Transportation considering Incremental Quantity Discount

    Directory of Open Access Journals (Sweden)

    Weiya Chen

    2014-01-01

    Full Text Available This paper presents a mixed integer linear programming model (MILP for optimizing the hybrid hub-and-spoke network operation for a less-than-truckload transportation service. The model aims to minimize the total operation costs (transportation cost and transfer cost, given the determined demand matrix, truck load capacity, and uncapacitated road transportation. The model also incorporates an incremental quantity discount function to solve the reversal of the total cost and the total demand. The model is applied to a real case of a Chinese transportation company engaged in nationwide freight transportation. The numerical example shows that, with uncapacitated road transportation, the total costs and the total vehicle trips of the hybrid hub-and-spoke network operation are, respectively, 8.0% and 15.3% less than those of the pure hub-and-spoke network operation, and the assumed capacity constraints in an extension model result in more target costs on the hybrid hub-and-spoke network. The two models can be used to support the decision making in network operations by transportation and logistics companies.

  1. The role of FlhF and HubP as polar landmark proteins in Shewanella putrefaciens CN-32.

    Science.gov (United States)

    Rossmann, Florian; Brenzinger, Susanne; Knauer, Carina; Dörrich, Anja K; Bubendorfer, Sebastian; Ruppert, Ulrike; Bange, Gert; Thormann, Kai M

    2015-11-01

    Spatiotemporal regulation of cell polarity plays a role in many fundamental processes in bacteria and often relies on 'landmark' proteins which recruit the corresponding clients to their designated position. Here, we explored the localization of two multi-protein complexes, the polar flagellar motor and the chemotaxis array, in Shewanella putrefaciens CN-32. We demonstrate that polar positioning of the flagellar system, but not of the chemotaxis system, depends on the GTPase FlhF. In contrast, the chemotaxis array is recruited by a transmembrane protein which we identified as the functional ortholog of Vibrio cholerae HubP. Mediated by its periplasmic N-terminal LysM domain, SpHubP exhibits an FlhF-independent localization pattern during cell cycle similar to its Vibrio counterpart and also has a role in proper chromosome segregation. In addition, while not affecting flagellar positioning, SpHubP is crucial for normal flagellar function and is involved in type IV pili-mediated twitching motility. We hypothesize that a group of HubP/FimV homologs, characterized by a rather conserved N-terminal periplasmic section required for polar targeting and a highly variable acidic cytoplasmic part, primarily mediating recruitment of client proteins, serves as polar markers in various bacterial species with respect to different cellular functions. © 2015 John Wiley & Sons Ltd.

  2. Dynamic Migration Intentions and the Impact of Socio-Institutional Environments: A Transit Migration Hub in Turkey

    NARCIS (Netherlands)

    Wissink, M.J.; Düvell, F.; van Eerdewijk, A.

    2013-01-01

    Transit migration is generally defined by migrants having the intention to move onwards to a third country. Based on an empirical investigation in Izmir, a transit migration hub in Turkey, this paper critically discusses intentionality as a valid dimension in conceptualisations of transit migration.

  3. Application of a Non-linear Program to the Establishment of a Hub and Spoke System in Africa

    Science.gov (United States)

    2010-06-01

    areas of commerce, light manufacturing, and the tourism industry (United States Department of State, 2009). Generally speaking, Kenya maintains a...possess commercial and/or military vehicle and equipment repair facilities that could be used to maintain CF materiel in theatre . The Hub...

  4. Dynamic Migration Intentions and the Impact of Socio-Institutional Environments: A Transit Migration Hub in Turkey

    NARCIS (Netherlands)

    Wissink, M.J.; Düvell, F.; van Eerdewijk, A.

    2013-01-01

    Transit migration is generally defined by migrants having the intention to move onwards to a third country. Based on an empirical investigation in Izmir, a transit migration hub in Turkey, this paper critically discusses intentionality as a valid dimension in conceptualisations of transit migration.

  5. The Quest for Regional Hub of Education: Growing Heterarchies, Organizational Hybridization, and New Governance in Singapore and Malaysia

    Science.gov (United States)

    Mok, Ka Ho

    2011-01-01

    With strong intention to enhance the global competitiveness of their higher education systems, the governments of Singapore and Malaysia have made attempts to develop their societies into regional hubs of education; hence transnational education has become increasingly popular in these societies. In order to attract more students from overseas to…

  6. Hub vortex helical instability as the origin of wake meandering in the lee of a model wind-turbine

    Science.gov (United States)

    Viola, Francesco; Iungo, Giacomo Valerio; Camarri, Simone; Porte-Agel, Fernando; Gallaire, Francois

    2012-11-01

    Wind tunnel measurements were performed for the wake produced by a three-bladed wind turbine immersed in uniform flow. These tests show the presence of a vorticity structure in the near wake region mainly oriented along the streamwise direction, which is denoted as hub vortex. The hub vortex is characterized by oscillations with frequencies lower than the one connected to the rotational velocity of the rotor, which are ascribed to wake meandering by previous works. This phenomenon consists in transversal oscillations of the wind turbine wake, which are excited by the shedding of vorticity structures from the rotor disc acting as a bluff body. In this work temporal and spatial linear stability analyses of a wind turbine wake are performed on a base flow obtained through time-averaged wind tunnel velocity measurements. This study shows that the low frequency spectral component detected experimentally is the result of a convective instability of the hub vortex, which is characterized by a counter-winding single-helix structure. Simultaneous hot-wire measurements confirm the presence of a helicoidal unstable mode of the hub vortex with a streamwise wavenumber roughly equal to the one predicted from the linear instability analysis.

  7. Developing and Launching an Online Hub to Facilitate the Exchange of Research Knowledge in Education: The Case of the OERE

    Science.gov (United States)

    Tuters, Stephanie; Read, Robyn; Harris, Shasta Carr; Anwar, Arif; Levin, Ben

    2012-01-01

    This paper outlines the process by which the Ontario Education Research Exchange (OERE), part of the Knowledge Network of Applied Education Research, developed and launched an online hub of education research summaries to facilitate greater use of research by stakeholders in the field of education. The project is an effort in knowledge…

  8. Debate over a Proposed FedEx Distribution Hub: Examining the Role of Consensus, Power and Norms of Communication Ethics.

    Science.gov (United States)

    Thompson, Kathleen B.

    This paper examines an ongoing community debate over a proposed FedEx distribution hub to be constructed at the local airport. The essay looks to theorists, including Patsy Healey, Richard Johannesen, Daniel Kemmis, James Klumpp, and Martha Nussbaum. These theorists provide a way to view the role of consensus, power, and norms of communication…

  9. THE CITY ISOMORPHISM FOR COMPREHENSIVE TRANSPORT HUB%综合交通枢纽的城市同构

    Institute of Scientific and Technical Information of China (English)

    魏崴

    2014-01-01

    The urban comprehensive transport hub comprises of multi-function transport facilities with great traffic characteristics like airport, harbor, country railways, metro-subway, public transportation, and crossover road. Both the deficiency of urban construction land and the limitation of severe environmental condition reflect the comprehensive urban problems. We need to integrate the present urban conditions and summarize the system of large-scale comprehensive transport hub, in order to intergrate the traffic system with the urban environment in the hub areas and to promote the interactive relationship between the service of traffic hub and the sustainable urban development. These are the core problems that the urban comprehensive transport hub faces nowadays. The article attempts to focus on the integration of transport hub space for railway station and the urban construction, to make a study on the design strategy of the coordinated development of the comprehensive transport hub and the urban construction, in order to broaden our perspective and make a wider horizon for the future healthy development of our city.%城市大型综合交通枢纽涵盖空港、海港、国铁、城市轨道交通、公交,以及立交道路等市政设施多元功能为一体,具有极强的交通特征。而城市建设用地紧张,环境制约因素繁多,反映了综合的城市问题。整合现有城市条件,梳理大型综合交通枢纽系统,实现枢纽地区交通组织和城市环境的融合,促进交通枢纽服务于城市可持续发展的互动关系,是城市综合交通枢纽建设面临的核心问题。本文尝试围绕铁路客站区域交通枢纽空间与城市建设一体化发展,研究综合交通枢纽与城市建设协同发展的设计策略,为探索城市未来的良性发展开拓思路,开启更为广阔的前景。

  10. Computational Framework for Prediction of Peptide Sequences That May Mediate Multiple Protein Interactions in Cancer-Associated Hub Proteins.

    Directory of Open Access Journals (Sweden)

    Debasree Sarkar

    Full Text Available A considerable proportion of protein-protein interactions (PPIs in the cell are estimated to be mediated by very short peptide segments that approximately conform to specific sequence patterns known as linear motifs (LMs, often present in the disordered regions in the eukaryotic proteins. These peptides have been found to interact with low affinity and are able bind to multiple interactors, thus playing an important role in the PPI networks involving date hubs. In this work, PPI data and de novo motif identification based method (MEME were used to identify such peptides in three cancer-associated hub proteins-MYC, APC and MDM2. The peptides corresponding to the significant LMs identified for each hub protein were aligned, the overlapping regions across these peptides being termed as overlapping linear peptides (OLPs. These OLPs were thus predicted to be responsible for multiple PPIs of the corresponding hub proteins and a scoring system was developed to rank them. We predicted six OLPs in MYC and five OLPs in MDM2 that scored higher than OLP predictions from randomly generated protein sets. Two OLP sequences from the C-terminal of MYC were predicted to bind with FBXW7, component of an E3 ubiquitin-protein ligase complex involved in proteasomal degradation of MYC. Similarly, we identified peptides in the C-terminal of MDM2 interacting with FKBP3, which has a specific role in auto-ubiquitinylation of MDM2. The peptide sequences predicted in MYC and MDM2 look promising for designing orthosteric inhibitors against possible disease-associated PPIs. Since these OLPs can interact with other proteins as well, these inhibitors should be specific to the targeted interactor to prevent undesired side-effects. This computational framework has been designed to predict and rank the peptide regions that may mediate multiple PPIs and can be applied to other disease-associated date hub proteins for prediction of novel therapeutic targets of small molecule PPI

  11. Computational Framework for Prediction of Peptide Sequences That May Mediate Multiple Protein Interactions in Cancer-Associated Hub Proteins

    Science.gov (United States)

    Sarkar, Debasree; Patra, Piya; Ghosh, Abhirupa; Saha, Sudipto

    2016-01-01

    A considerable proportion of protein-protein interactions (PPIs) in the cell are estimated to be mediated by very short peptide segments that approximately conform to specific sequence patterns known as linear motifs (LMs), often present in the disordered regions in the eukaryotic proteins. These peptides have been found to interact with low affinity and are able bind to multiple interactors, thus playing an important role in the PPI networks involving date hubs. In this work, PPI data and de novo motif identification based method (MEME) were used to identify such peptides in three cancer-associated hub proteins—MYC, APC and MDM2. The peptides corresponding to the significant LMs identified for each hub protein were aligned, the overlapping regions across these peptides being termed as overlapping linear peptides (OLPs). These OLPs were thus predicted to be responsible for multiple PPIs of the corresponding hub proteins and a scoring system was developed to rank them. We predicted six OLPs in MYC and five OLPs in MDM2 that scored higher than OLP predictions from randomly generated protein sets. Two OLP sequences from the C-terminal of MYC were predicted to bind with FBXW7, component of an E3 ubiquitin-protein ligase complex involved in proteasomal degradation of MYC. Similarly, we identified peptides in the C-terminal of MDM2 interacting with FKBP3, which has a specific role in auto-ubiquitinylation of MDM2. The peptide sequences predicted in MYC and MDM2 look promising for designing orthosteric inhibitors against possible disease-associated PPIs. Since these OLPs can interact with other proteins as well, these inhibitors should be specific to the targeted interactor to prevent undesired side-effects. This computational framework has been designed to predict and rank the peptide regions that may mediate multiple PPIs and can be applied to other disease-associated date hub proteins for prediction of novel therapeutic targets of small molecule PPI modulators. PMID

  12. Government teeters on edge of collapse / Aleksei Gunter

    Index Scriptorium Estoniae

    Gunter, Aleksei, 1979-

    2005-01-01

    Valitsuses tekkinud kriisist seoses justiitsministri korruptsiooni vastu võitlemise programmiga. Lisa: Res Publica ja Keskerakond ühinesid Tallinnas. Tabel: Kohtade jagunemine erakondade vahel Riigikogus

  13. Government teeters on edge of collapse / Aleksei Gunter

    Index Scriptorium Estoniae

    Gunter, Aleksei, 1979-

    2005-01-01

    Valitsuses tekkinud kriisist seoses justiitsministri korruptsiooni vastu võitlemise programmiga. Lisa: Res Publica ja Keskerakond ühinesid Tallinnas. Tabel: Kohtade jagunemine erakondade vahel Riigikogus

  14. Transport of pollutants and sediment in the area of the Wave Hub (Celtic Sea)

    Science.gov (United States)

    Shapiro, Georgy; Huntley, David

    2010-05-01

    Ocean waves are a sustainable source of alternative energy that, if properly developed, will provide a quarter of current electricity demand and contribute to lowering the UK's reliance on fossil fuels. The UK government has given planning approval for a pilot power plant called the Wave Hub located in the eastern Celtic Sea off the Cornish north coast. The impact of a small number of devices on the physical environment is expected to be subtle outside the exclusion zone. However, such pilot projects are considered as the launching pad in the UK's ambitious programme to create a new wave energy industry. Large scale off-shore industrial activity can interact with the physical environment of the shelf sea in a two-fold manner: (i) the wave farm is affected by the waves, currents, variation in temperature and movements of sediment, and (ii) it can impact on the marine environment via a number of ways including release of dissolved and suspended matter during construction, operational and decommission stages of the project. These changes in the physical environment can then be translated into changes of the ecosystem and corresponding human activities. The Celtic Sea has a highly variable and complex thermal structure. In the spring and summer the water column becomes stratified due to solar heating of the surface layer, particularly in the areas of greater depth and/or low currents, where the turbulence is insufficient to mix the entire water column. Fronts form at the junctions of stratified and mixed water columns and these fronts generate currents which flow along the fronts. These frontal currents are subject to baroclinic instability and generate a whole set of mesoscale (i.e. comparable with the baroclinic Rossby radius) features such as eddies, filaments and mushroom currents, which are clearly seen on satellite images. Ecosystems are particularly concentrated in the vicinity of fronts so changes in frontal strength or location can have significant biological

  15. Identifying the Functional Requirements for an Arizona Astronomy Data Hub (AADH)

    Science.gov (United States)

    Stahlman, G.; Heidorn, P. B.

    2015-12-01

    Astronomy data represent a curation challenge for information managers, as well as for astronomers. Extracting knowledge from these heterogeneous and complex datasets is particularly complicated and requires both interdisciplinary and domain expertise to accomplish true curation, with an overall goal of facilitating reproducible science through discoverability and persistence. A group of researchers and professional staff at the University of Arizona held several meetings during the spring of 2015 about astronomy data and the role of the university in curation of that data. The group decided that it was critical to obtain a broader consensus on the needs of the community. With assistance from a Start for Success grant provided by the University of Arizona Office of Research and Discovery and funding from the American Astronomical Society (AAS), a workshop was held in early July 2015, with 28 participants plus 4 organizers in attendance. Representing University researchers as well as astronomical facilities and a scholarly society, the group verified that indeed there is a problem with the long-term curation of some astronomical data not associated with major facilities, and that a repository or "data hub" with the correct functionality could facilitate research and the preservation and use of astronomy data. The workshop members also identified a set of next steps, including the identification of possible data and metadata to be included in the Hub. The participants further helped to identify additional information that must be gathered before construction of the AADH could begin, including identifying significant datasets that do not currently have sufficient preservation and dissemination infrastructure, as well as some data associated with journal publications and the broader context of the data beyond that directly published in the journals. Workshop participants recommended that a set of grant proposal should be developed that ensures community buy-in and

  16. Effects of Comprehensive High-speed Transportation Hubs on Spatial Structure of Urban Development: A Case Study on Changsha-Zhuzhou-Xiangtan Area

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    This paper, by studying the mechanism of the spatial restructuring of urban development and the effects of comprehensive high-speed transportation hubs on it, analyzes the development trends of comprehensive high-speed transportation in Changsha-Zhuzhou-Xiangtan Area and the impacts of the growing urban area centered on comprehensive high-speed transportation hubs, like airport and high-speed railway station, on the urban development of this area. It also proposes some strategies for the spatial restructuring of Changsha-Zhuzhou-Xiangtan Area in view of the development of the comprehensive high-speed transportation hubs, like Huanghua Airport and Wuhan-Guangzhou High-speed Railway Station.

  17. Discussion on Development Mode of Large Railway Hubs in High-speed Rail Era:From Transportation Complex to Urban Complex

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    At present, most of China’s railway hubs are developed to be transportation complexes, with some problems like unsmooth traffic circulation, mixed but disordered functions, separated spaces, etc. In high-speed rail era, high-speed railway hubs should be regarded as the catalyst to promoted urban development. The mode of urban complex should be developed, to closely connect the railway hub and the surrounding area within walking distance, so as people could get to their destinations in the most convenient way. Furthermore, it would strengthen people’s aggregation, thus to bring about larger scale urban development by the successful development of urban complex.

  18. GSTP1 is a hub gene for gene-air pollution interactions on childhood asthma.

    Science.gov (United States)

    Su, M W; Tsai, C H; Tung, K Y; Hwang, B F; Liang, P H; Chiang, B L; Yang, Y H; Lee, Y L

    2013-12-01

    There is growing evidence that multiple genes and air pollutants are associated with asthma. By identifying the effect of air pollution on the general population, the effects of air pollution on childhood asthma can be better understood. We conducted the Taiwan Children Health Study (TCHS) to investigate the influence of gene-air pollution interactions on childhood asthma. Complete monitoring data for the ambient air pollutants were collected from Taiwan Environmental Protection Agency air monitoring stations. Our results show a significant two-way gene-air pollution interaction between glutathione S-transferase P (GSTP1) and PM10 on the risk of childhood asthma. Interactions between GSTP1 and different types of air pollutants have a higher information gain than other gene-air pollutant combinations. Our study suggests that interaction between GSTP1 and PM10 is the most influential gene-air pollution interaction model on childhood asthma. The different types of air pollution combined with the GSTP1 gene may alter the susceptibility to childhood asthma. It implies that GSTP1 is an important hub gene in the anti-oxidative pathway that buffers the harmful effects of air pollution. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  19. Gene expression patterns combined with network analysis identify hub genes associated with bladder cancer.

    Science.gov (United States)

    Bi, Dongbin; Ning, Hao; Liu, Shuai; Que, Xinxiang; Ding, Kejia

    2015-06-01

    To explore molecular mechanisms of bladder cancer (BC), network strategy was used to find biomarkers for early detection and diagnosis. The differentially expressed genes (DEGs) between bladder carcinoma patients and normal subjects were screened using empirical Bayes method of the linear models for microarray data package. Co-expression networks were constructed by differentially co-expressed genes and links. Regulatory impact factors (RIF) metric was used to identify critical transcription factors (TFs). The protein-protein interaction (PPI) networks were constructed by the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and clusters were obtained through molecular complex detection (MCODE) algorithm. Centralities analyses for complex networks were performed based on degree, stress and betweenness. Enrichment analyses were performed based on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. Co-expression networks and TFs (based on expression data of global DEGs and DEGs in different stages and grades) were identified. Hub genes of complex networks, such as UBE2C, ACTA2, FABP4, CKS2, FN1 and TOP2A, were also obtained according to analysis of degree. In gene enrichment analyses of global DEGs, cell adhesion, proteinaceous extracellular matrix and extracellular matrix structural constituent were top three GO terms. ECM-receptor interaction, focal adhesion, and cell cycle were significant pathways. Our results provide some potential underlying biomarkers of BC. However, further validation is required and deep studies are needed to elucidate the pathogenesis of BC. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Distortion and residual stresses in laser beam weld shaft-hub joints

    Science.gov (United States)

    Buschenhenke, F.; Hofmann, M.; Seefeld, T.; Vollertsen, F.

    In laser beam welding, a serious challenge is to control the distortion during the process. Understanding the whole process chain in view of different distortion potentials applied in each processing step provides the ability to control the distortion of the welded components. Every manufacturing step induces residual stresses in the component which can be released by the heat of the welding process, while further residual stresses are introduced into the welded parts upon cooling. The laser beam sources of the new generation permit a high power welding process and high beam quality at the same time. These laser beams are capable of producing deep and narrow seams. Thus the thermal strains of the joined parts are expected to be minimized. Especially axial welded shaft-hub joints show an irregular distribution of bending deformation, which is caused by the self-influencing welding gap. This work deals with the investigation of different laser beam sources and their effect on the welding distortion in axial welded shafthub joints made of steel (20MnCr5). The aim of the work done was to achieve minimal distortion after the welding process. To characterize the influences on the distortion behaviour of the welded parts, residual stresses have been determined by neutron diffraction.

  1. One hub-one process: a tool based view on regulatory network topology

    Directory of Open Access Journals (Sweden)

    Sneppen Kim

    2008-03-01

    Full Text Available Abstract Background The relationship between the regulatory design and the functionality of molecular networks is a key issue in biology. Modules and motifs have been associated to various cellular processes, thereby providing anecdotal evidence for performance based localization on molecular networks. Results To quantify structure-function relationship we investigate similarities of proteins which are close in the regulatory network of the yeast Saccharomyces Cerevisiae. We find that the topology of the regulatory network only show weak remnants of its history of network reorganizations, but strong features of co-regulated proteins associated to similar tasks. These functional correlations decreases strongly when one consider proteins separated by more than two steps in the regulatory network. The network topology primarily reflects the processes that is orchestrated by each individual hub, whereas there is nearly no remnants of the history of protein duplications. Conclusion Our results suggests that local topological features of regulatory networks, including broad degree distributions, emerge as an implicit result of matching a number of needed processes to a finite toolbox of proteins.

  2. Identification of regulatory network hubs that control lipid metabolism in Chlamydomonas reinhardtii.

    Science.gov (United States)

    Gargouri, Mahmoud; Park, Jeong-Jin; Holguin, F Omar; Kim, Min-Jeong; Wang, Hongxia; Deshpande, Rahul R; Shachar-Hill, Yair; Hicks, Leslie M; Gang, David R

    2015-08-01

    Microalgae-based biofuels are promising sources of alternative energy, but improvements throughout the production process are required to establish them as economically feasible. One of the most influential improvements would be a significant increase in lipid yields, which could be achieved by altering the regulation of lipid biosynthesis and accumulation. Chlamydomonas reinhardtii accumulates oil (triacylglycerols, TAG) in response to nitrogen (N) deprivation. Although a few important regulatory genes have been identified that are involved in controlling this process, a global understanding of the larger regulatory network has not been developed. In order to uncover this network in this species, a combined omics (transcriptomic, proteomic and metabolomic) analysis was applied to cells grown in a time course experiment after a shift from N-replete to N-depleted conditions. Changes in transcript and protein levels of 414 predicted transcription factors (TFs) and transcriptional regulators (TRs) were monitored relative to other genes. The TF and TR genes were thus classified by two separate measures: up-regulated versus down-regulated and early response versus late response relative to two phases of polar lipid synthesis (before and after TAG biosynthesis initiation). Lipidomic and primary metabolite profiling generated compound accumulation levels that were integrated with the transcript dataset and TF profiling to produce a transcriptional regulatory network. Evaluation of this proposed regulatory network led to the identification of several regulatory hubs that control many aspects of cellular metabolism, from N assimilation and metabolism, to central metabolism, photosynthesis and lipid metabolism.

  3. The Spleen: A Hub Connecting Nervous and Immune Systems in Cardiovascular and Metabolic Diseases

    Directory of Open Access Journals (Sweden)

    Andrea Lori

    2017-06-01

    Full Text Available Metabolic disorders have been identified as major health problems affecting a large portion of the world population. In addition, obesity and insulin resistance are principal risk factors for the development of cardiovascular diseases. Altered immune responses are common features of both hypertension and obesity and, moreover, the involvement of the nervous system in the modulation of immune system is gaining even more attention in both pathophysiological contexts. For these reasons, during the last decades, researches focused their efforts on the comprehension of the molecular mechanisms connecting immune system to cardiovascular and metabolic diseases. On the other hand, it has been reported that in these pathological conditions, central neural pathways modulate the activity of the peripheral nervous system, which is strongly involved in onset and progression of the disease. It is interesting to notice that neural reflex can also participate in the modulation of immune functions. In this scenario, the spleen becomes the crucial hub allowing the interaction of different systems differently involved in metabolic and cardiovascular diseases. Here, we summarize the major findings that dissect the role of the immune system in disorders related to metabolic and cardiovascular dysfunctions, and how this could also be influenced by neural reflexes.

  4. The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet and Its Hub Components

    Directory of Open Access Journals (Sweden)

    Dasiel O. Borroto-Escuela

    2014-05-01

    Full Text Available G protein-coupled receptors (GPCRs oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner. However, despite the current development of experimental techniques for large-scale detection of GPCR heteromers, in order to understand their connectivity it is necessary to develop novel tools to study the global heteroreceptor networks. To provide insight into the overall topology of the GPCR heteromers and identify key players, a collective interaction network was constructed. Experimental interaction data for each of the individual human GPCR protomers was obtained manually from the STRING and SCOPUS databases. The interaction data were used to build and analyze the network using Cytoscape software. The network was treated as undirected throughout the study. It is comprised of 156 nodes, 260 edges and has a scale-free topology. Connectivity analysis reveals a significant dominance of intrafamily versus interfamily connections. Most of the receptors within the network are linked to each other by a small number of edges. DRD2, OPRM, ADRB2, AA2AR, AA1R, OPRK, OPRD and GHSR are identified as hubs. In a network representation 10 modules/clusters also appear as a highly interconnected group of nodes. Information on this GPCR network can improve our understanding of molecular integration. GPCR-HetNet has been implemented in Java and is freely available at http://www.iiia.csic.es/~ismel/GPCR-Nets/index.html.

  5. The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components.

    Science.gov (United States)

    Borroto-Escuela, Dasiel O; Brito, Ismel; Romero-Fernandez, Wilber; Di Palma, Michael; Oflijan, Julia; Skieterska, Kamila; Duchou, Jolien; Van Craenenbroeck, Kathleen; Suárez-Boomgaard, Diana; Rivera, Alicia; Guidolin, Diego; Agnati, Luigi F; Fuxe, Kjell

    2014-05-14

    G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner. However, despite the current development of experimental techniques for large-scale detection of GPCR heteromers, in order to understand their connectivity it is necessary to develop novel tools to study the global heteroreceptor networks. To provide insight into the overall topology of the GPCR heteromers and identify key players, a collective interaction network was constructed. Experimental interaction data for each of the individual human GPCR protomers was obtained manually from the STRING and SCOPUS databases. The interaction data were used to build and analyze the network using Cytoscape software. The network was treated as undirected throughout the study. It is comprised of 156 nodes, 260 edges and has a scale-free topology. Connectivity analysis reveals a significant dominance of intrafamily versus interfamily connections. Most of the receptors within the network are linked to each other by a small number of edges. DRD2, OPRM, ADRB2, AA2AR, AA1R, OPRK, OPRD and GHSR are identified as hubs. In a network representation 10 modules/clusters also appear as a highly interconnected group of nodes. Information on this GPCR network can improve our understanding of molecular integration. GPCR-HetNet has been implemented in Java and is freely available at http://www.iiia.csic.es/~ismel/GPCR-Nets/index.html.

  6. A Real-Time Web Services Hub to Improve Situation Awareness during Flash Flood Events

    Science.gov (United States)

    Salas, F. R.; Liu, F.; Maidment, D. R.; Hodges, B. R.

    2011-12-01

    The central Texas corridor is one of the most flash flood-prone regions in the United States. Over the years, flash floods have resulted in hundreds of flood fatalities and billions of dollars in property damage. In order to mitigate risk to residents and infrastructure during flood events, both citizens and emergency responders need to exhibit proactive behavior instead of reactive. Real-time and forecasted flood information is fairly limited and hard to come by at varying spatial scales. The University of Texas at Austin has collaborated with IBM Research-Austin and ESRI to build a distributed real-time flood information system through a framework that leverages large scale data management and distribution, Open Geospatial Consortium standardized web services, and smart map applications. Within this paradigm, observed precipitation data encoded in WaterML is ingested into HEC-HMS and then delivered to a high performance hydraulic routing software package developed by IBM that utilizes the latest advancements in VLSI design, numerical linear algebra and numerical integration techniques on contemporary multicore architecture to solve fully dynamic Saint Venant equations at both small and large scales. In this paper we present a real-time flood inundation map application that in conjunction with a web services Hub, seamlessly integrates hydrologic information available through both public and private data services, model services and mapping services. As a case study for this project, we demonstrate how this system has been implemented in the City of Austin, Texas.

  7. Morphological, Anatomical and Palynological Studies on Endemic Matthiola anchoniifolia Hub. -Mor. (Brassicaceae

    Directory of Open Access Journals (Sweden)

    Mehmet TEKIN

    2013-05-01

    Full Text Available In this paper, anatomical, palynological and seed micromorphological properties of an endemic plant Matthiola anchoniifolia Hub.-Mor. are recorded for the first time. A description and descriptive illustrations of the species are given based on the collected specimens for morphological study. Seed surface of M. anchoniifolia is examined by scanning electron microscope. The seed of M. anchoniifolia was compressed, brownish in colour and the cells of testa were nearly 60-80 μm in diameter and ranged from isodiametric, tetragonal or pentagonal. The anticlinal walls were straight or weakly curved while the outer periclinal walls were concave to flat with smooth surface. In anatomical study, cross sections of root, stem and stem leaf are examined. The root had secondary structure. Periderm consists of 5-8 layers of cells for phellem. Cortex consists of 9-12 layered parenchymatic tissue under the periderm. Secondary phloem ring-shaped, 6-9 layered and consists of companion cells and grouped sieve tubes. Stem had primary structure when analyzed. It is circular with a few irregular ribs in cross section. Cortex is 8-12 layered and parenchymatous. Stoma cells are present on both epidermis. Leaf is isobilateral. There are unicellular and ramified hairs on both surface. Palisade parenchyma cells are 1-2 layered and spongy parenchyma cells are 5-12 layered. M. anchoniifolia has tricolpate pollen type, prolate pollen shape and reticulate exine ornamentation.

  8. a Virtual Hub Brokering Approach for Integration of Historical and Modern Maps

    Science.gov (United States)

    Bruno, N.; Previtali, M.; Barazzetti, L.; Brumana, R.; Roncella, R.

    2016-06-01

    Geospatial data are today more and more widespread. Many different institutions, such as Geographical Institutes, Public Administrations, collaborative communities (e.g., OSM) and web companies, make available nowadays a large number of maps. Besides this cartography, projects of digitizing, georeferencing and web publication of historical maps have increasingly spread in the recent years. In spite of these variety and availability of data, information overload makes difficult their discovery and management: without knowing the specific repository where the data are stored, it is difficult to find the information required and problems of interconnection between different data sources and their restricted interoperability limit a wide utilization of available geo-data. This paper aims to describe some actions performed to assure interoperability between data, in particular spatial and geographic data, gathered from different data providers, with different features and referring to different historical periods. The article summarizes and exemplifies how, starting from projects of historical map digitizing and Historical GIS implementation, respectively for the Lombardy and for the city of Parma, the interoperability is possible in the framework of the ENERGIC OD project. The European project ENERGIC OD, thanks to a specific component - the virtual hub - based on a brokering framework, copes with the previous listed problems and allows the interoperability between different data sources.

  9. AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome.

    Science.gov (United States)

    Gaetani, Massimiliano; Matafora, Vittoria; Saare, Mario; Spiliotopoulos, Dimitrios; Mollica, Luca; Quilici, Giacomo; Chignola, Francesca; Mannella, Valeria; Zucchelli, Chiara; Peterson, Pärt; Bachi, Angela; Musco, Giovanna

    2012-12-01

    Mutations in autoimmune regulator (AIRE) gene cause autoimmune polyendocrinopathy candidiasis ectodermal dystrophy. AIRE is expressed in thymic medullary epithelial cells, where it promotes the expression of peripheral-tissue antigens to mediate deletional tolerance, thereby preventing self-reactivity. AIRE contains two plant homeodomains (PHDs) which are sites of pathological mutations. AIRE-PHD fingers are important for AIRE transcriptional activity and presumably play a crucial role in the formation of multimeric protein complexes at chromatin level which ultimately control immunological tolerance. As a step forward the understanding of AIRE-PHD fingers in normal and pathological conditions, we investigated their structure and used a proteomic SILAC approach to assess the impact of patient mutations targeting AIRE-PHD fingers. Importantly, both AIRE-PHD fingers are structurally independent and mutually non-interacting domains. In contrast to D297A and V301M on AIRE-PHD1, the C446G mutation on AIRE-PHD2 destroys the structural fold, thus causing aberrant AIRE localization and reduction of AIRE target genes activation. Moreover, mutations targeting AIRE-PHD1 affect the formation of a multimeric protein complex at chromatin level. Overall our results reveal the importance of AIRE-PHD domains in the interaction with chromatin-associated nuclear partners and gene regulation confirming the role of PHD fingers as versatile protein interaction hubs for multiple binding events.

  10. A Multi-Objective, Hub-and-Spoke Supply Chain Design Model for Densified Biomass

    Energy Technology Data Exchange (ETDEWEB)

    Jacob J. Jacobson; Md. S. Roni; Kara G. Cafferty; Sandra D. Eksioglu

    2014-06-01

    In this paper we propose a model to design the supply chain for densified biomass. Rail is typically used for longhaul, high-volume shipment of densified biomass. This is the reason why a hub-and-spoke network structure is used to model this supply chain. The model is formulated as a multi-objective, mixed-integer programing problem under economic, environmental, and social criteria. The goal is to identify the feasibility of meeting the Renewable Fuel Standard (RFS) by using biomass for production of cellulosic ethanol. The focus is not just on the costs associated with meeting these standards, but also exploring the social and environmental benefits that biomass production and processing offers by creating new jobs and reducing greenhouse gas (GHG) emissions. We develop an augmented ?-constraint method to find the exact Pareto solution to this optimization problem. We develop a case study using data from the Mid-West. The model identifies the number, capacity and location of biorefineries needed to make use of the biomass available in the region. The model estimates the delivery cost of cellulosic ethanol under different scenario, the number new jobs created and the GHG emission reductions in the supply chain.

  11. A Multi-Objective, Hub-and-Spoke Supply Chain Design Model For Densified Biomass

    Energy Technology Data Exchange (ETDEWEB)

    Md S. Roni; Sandra Eksioglu; Kara G. Cafferty

    2014-06-01

    In this paper we propose a model to design the supply chain for densified biomass. Rail is typically used for long-haul, high-volume shipment of densified biomass. This is the reason why a hub-and-spoke network structure is used to model this supply chain. The model is formulated as a multi-objective, mixed-integer programing problem under economic, environmental, and social criteria. The goal is to identify the feasibility of meeting the Renewable Fuel Standard (RFS) by using biomass for production of cellulosic ethanol. The focus in not just on the costs associated with meeting these standards, but also exploring the social and environmental benefits that biomass production and processing offers by creating new jobs and reducing greenhouse gas (GHG) emissions. We develop an augmented ?-constraint method to find the exact Pareto solution to this optimization problem. We develop a case study using data from the Mid-West. The model identifies the number, capacity and location of biorefineries needed to make use of the biomass available in the region. The model estimates the delivery cost of cellulosic ethanol under different scenario, the number new jobs created and the GHG emission reductions in the supply chain.

  12. Dynamical predictions of insular hubs for social cognition and their application to stroke

    Directory of Open Access Journals (Sweden)

    Roberto eLimongi

    2014-11-01

    Full Text Available The insular cortex (IC is considered a rich hub for context-sensitive emotions/social cognition. Patients with focal IC stroke provide unique opportunities to study socio-emotional processes. Nevertheless, Couto et al. [Insular networks for emotional processing and social cognition. Cortex. 2013, 49:1420-34] have recently reported controversial results regarding IC involvement in emotion and social cognition. Similarly, patients with similar lesions show high functional variability, ranging from almost totally preserved to strongly impaired behavior. Critical evidence suggests that the variability of these patients in the above domains can be explained by enhanced neuroplasticity, compensatory processes, and functional remapping after stroke. Therefore, socio-emotional processes would depend on long-distance connections between the IC and frontotemporal regions. We propose that predictive coding and effective connectivity represent a novel approach to explore functional connectivity and assess compensatory, contralateral, and subsidiary network differences among focal stroke patients. This approach would help explain why socio-emotional performance is so variable within this population.

  13. Transforming the New Brunswick Energy Hub: An Analysis on Renewable Energy

    Science.gov (United States)

    Gunter, Christopher

    This research examines the benefits and disadvantages of instituting a shift from fossil fuel dependence to renewable sources of energy in New Brunswick. The New Brunswick Energy Hub is a complex system acting under the mandate of the White Paper New Brunswick Energy Policy. In my research, I consider information derived from statistical indicators developed by Patlitzianas, Doukas, Kagiannas and Psarras (2008) and compare these findings to the efficacy of energy policies in Germany, Denmark and Spain. These countries are similar to New Brunswick in climate and organizational complexity (US Department of Commerce, 2009). Weighing the outcomes of this comparative study, I discuss my recommendations highlighting the environmental and economic benefits. My research investigates subsidies in each country that allowed them early economic and environmental advantages. Specific regional considerations, such as Denmark's trend of selling energy technology for profit over domestic applications, inform my conclusions. The future New Brunswick Energy Policy should focus on creating favorable conditions for renewable energy development to occur. Some proven conditions include infrastructure development subsidies and the development and annual review of a competitive open access transmission tariff. With the expiry of the current White Paper comes the necessity of this investigation, and the opportunity to address the growing financial and environmental concerns that many politicians and policy planners have failed to deal with in past policies.

  14. Evaluating NMME Seasonal Forecast Skill for use in NASA SERVIR Hub Regions

    Science.gov (United States)

    Roberts, J. Brent; Roberts, Franklin R.

    2013-01-01

    The U.S. National Multi-Model Ensemble seasonal forecasting system is providing hindcast and real-time data streams to be used in assessing and improving seasonal predictive capacity. The coupled forecasts have numerous potential applications, both national and international in scope. The NASA / USAID SERVIR project, which leverages satellite and modeling-based resources for environmental decision making in developing nations, is focusing on the evaluation of NMME forecasts specifically for use in driving applications models in hub regions including East Africa, the Hindu Kush- Himalayan (HKH) region and Mesoamerica. A prerequisite for seasonal forecast use in application modeling (e.g. hydrology, agriculture) is bias correction and skill assessment. Efforts to address systematic biases and multi-model combination in support of NASA SERVIR impact modeling requirements will be highlighted. Specifically, quantilequantile mapping for bias correction has been implemented for all archived NMME hindcasts. Both deterministic and probabilistic skill estimates for raw, bias-corrected, and multi-model ensemble forecasts as a function of forecast lead will be presented for temperature and precipitation. Complementing this statistical assessment will be case studies of significant events, for example, the ability of the NMME forecasts suite to anticipate the 2010/2011 drought in the Horn of Africa and its relationship to evolving SST patterns.

  15. The evolution of seed dormancy: environmental cues, evolutionary hubs, and diversification of the seed plants.

    Science.gov (United States)

    Willis, Charles G; Baskin, Carol C; Baskin, Jerry M; Auld, Josh R; Venable, D Lawrence; Cavender-Bares, Jeannine; Donohue, Kathleen; Rubio de Casas, Rafael

    2014-07-01

    Seed dormancy, by controlling the timing of germination, can strongly affect plant survival. The kind of seed dormancy, therefore, can influence both population and species-level processes such as colonization, adaptation, speciation, and extinction. We used a dataset comprising over 14,000 taxa in 318 families across the seed plants to test hypotheses on the evolution of different kinds of seed dormancy and their association with lineage diversification. We found morphophysiological dormancy to be the most likely ancestral state of seed plants, suggesting that physiologically regulated dormancy in response to environmental cues was present at the origin of seed plants. Additionally, we found that physiological dormancy (PD), once disassociated from morphological dormancy, acted as an 'evolutionary hub' from which other dormancy classes evolved, and that it was associated with higher rates of lineage diversification via higher speciation rates. The environmental sensitivity provided by dormancy in general, and by PD in particular, appears to be a key trait in the diversification of seed plants. © 2014 The Authors. New Phytologist © 2014 New Phytologist Trust.

  16. Using GitHub in the design of e-activities for software refactoring

    Directory of Open Access Journals (Sweden)

    Carlos LÓPEZ

    2015-12-01

    Full Text Available The aim of this work is to design, plan, apply and assessment educational activities to help in the teaching-learning process of the concept of refactoring. The teaching methodology used is based on two pillars. The first is a progressive learning of the concept of refactoring by e-activities defined at different levels of knowledge of Bloom’s taxonomy (knowledge, comprehension, application, analysis, synthesis, evaluation. The second is the use of resources in e-activities that are related to those the student may find during their professional career oriented towards software development: integrated development environments and software project repositories. The result of this work is the definition of a set of Java code refactoring e-activities. The version control functionality of software project repository, i.e.; GitHub, is used in different ways depending on the type of e-activity. Under these assumptions five types of e-activities are designed: Reading and comprehensions, objective tests, problem-based learning, case studies and webinars. The e-activities designed are applied in the context of the course Software Engineering of the Bachelor’s Degree in Computer Science at the University of Burgos. The paper concludes analyzing some consequences of the experience from the perspective of using these new e-activities in the teaching-learning process as from the perspective of workload involved for both the teacher and the student.

  17. A VIRTUAL HUB BROKERING APPROACH FOR INTEGRATION OF HISTORICAL AND MODERN MAPS

    Directory of Open Access Journals (Sweden)

    N. Bruno

    2016-06-01

    Full Text Available Geospatial data are today more and more widespread. Many different institutions, such as Geographical Institutes, Public Administrations, collaborative communities (e.g., OSM and web companies, make available nowadays a large number of maps. Besides this cartography, projects of digitizing, georeferencing and web publication of historical maps have increasingly spread in the recent years. In spite of these variety and availability of data, information overload makes difficult their discovery and management: without knowing the specific repository where the data are stored, it is difficult to find the information required and problems of interconnection between different data sources and their restricted interoperability limit a wide utilization of available geo-data. This paper aims to describe some actions performed to assure interoperability between data, in particular spatial and geographic data, gathered from different data providers, with different features and referring to different historical periods. The article summarizes and exemplifies how, starting from projects of historical map digitizing and Historical GIS implementation, respectively for the Lombardy and for the city of Parma, the interoperability is possible in the framework of the ENERGIC OD project. The European project ENERGIC OD, thanks to a specific component – the virtual hub – based on a brokering framework, copes with the previous listed problems and allows the interoperability between different data sources.

  18. Radicalization of the Settlers’ Youth: Hebron as a Hub for Jewish Extremism

    Directory of Open Access Journals (Sweden)

    Geneviève Boucher Boudreau

    2014-06-01

    Full Text Available The city of Hebron has been a hub for radicalization and terrorism throughout the modern history of Israel. This paper examines the past trends of radicalization and terrorism in Hebron and explains why it is still a present and rising ideology within the Jewish communities and organization such as the Hilltop Youth movement. The research first presents the transmission of social memory through memorials and symbolism of the Hebron hills area and then presents the impact of Meir Kahana’s movement. As observed, Hebron slowly grew and spread its population and philosophy to the then new settlement of Kiryat Arba. An exceptionally strong ideology of an extreme form of Judaism grew out of those two small towns. As analyzed—based on an exhaustive ethnographic fieldwork and bibliographic research—this form of fundamentalism and national-religious point of view gave birth to a new uprising of violence and radicalism amongst the settler youth organizations such as the Hilltop Youth movement.

  19. Partner Country Series: Developing a Natural Gas Trading Hub in Asia

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-06-01

    The trading of natural gas in the Asia-Pacific region is dominated by long-term contracts in which the price of gas is indexed to that of oil. As the price of gas between Asia and other parts of the world has widened in recent years, observers have raised serious doubts about the sustainability of this pricing model. In this report, the IEA shows what it would take to create a functional, regional natural-gas trading hub in which prices reflect the local supply and demand fundamentals. The report aims to provide stakeholders with insights on the changes that are required in the Asia-Pacific natural gas sector - both downstream and upstream - to allow a competitive natural gas price to emerge. Building on OECD Europe and OECD America experiences, this report sets out to assess perspectives for these changes in the Asia-Pacific natural gas markets. It identifies obstacles and opportunities for a competitive natural gas price in the Asian economies to emerge.

  20. Punching of lateral holes on automobile hub%汽车轮毂斜孔的冲制

    Institute of Scientific and Technical Information of China (English)

    黄晓慧; 吴向红

    2001-01-01

    介绍了汽车轮毂侧孔成形新方法的工作原理、模具结构及典型零件设计。该成形方法较传统的生产工艺有效率高、精度高等优点,并大大提高了零件动平衡能力,稳定了产品合格率。%The work principle, die structure and typical part design of the new forming method of lateral holes on automobile hub have been introduced. This new method has higher efficiency and precision than the traditional technology with stability of eligibility of product and has improved the dynamic balance ability and quality of automobile hub significantly.

  1. Implementation of preform-LCM process chain for the manufacturing of rotor hub shaft combination[Liquid Composite Molding

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    Concept of a waste-free preform-liquid composite molding (LCM) process chain for the production of composite parts is developed and implemented for an integral lightweight construction with improvement in their ecological and economical properties. This also enables new applications for the composite materials. A prototype of rotor hub and shaft combination (HSC) of a horizontal axis wind turbine was designed and manufactured using integral components and composite materials. The aim of this study was to reduce the costs and weight in comparison with individual parts of standard metallic hub and shaft. This approach in the later stage facilitates to reduce the system costs of wind turbines. In this paper, the basic concept of the HSC component and the preform-LCM process chain used for its manufacturing is presented. Major advantageous features of preform and LCM technology for the large structures are described in detail. (au)

  2. Stall Inception Process and Prospects for Active Hub-Flap Control in Three-Stage Axial Flow Compressor

    Institute of Scientific and Technical Information of China (English)

    Tomoya OKADA; Atsushi KAWAJIRI; Yutaka OHTA; Eisuke OUTA

    2008-01-01

    The possibility to apply the active hub-flap control method, which is a proven rotating stall control method for a single-stage compressor, to a 3-stage axial compressor is experimentally discussed, where complex rotating stall inception processes ate observed. The research compressor is a 3-stage one and could change the stagger angle settings for rotor blades and stator vanes. Sixteen rotor blade/stator vane configuration patterns were tested by changing stagger angle for the stator vanes. By measurement of surface-pressure fluctuation, stall inception proc-esses are investigated and the measured pressure fluctuation data is used as a predictive signal for rotating stall. The experimental results show that the stall detection system applied to active hub-flap control in a single-stage compressor could be usefully applied to that in a 3-stage compressor with a more complex stall inception process.

  3. A protein interaction atlas for the nuclear receptors: properties and quality of a hub-based dimerisation network

    Directory of Open Access Journals (Sweden)

    De Graaf David

    2007-07-01

    Full Text Available Abstract Background The nuclear receptors are a large family of eukaryotic transcription factors that constitute major pharmacological targets. They exert their combinatorial control through homotypic heterodimerisation. Elucidation of this dimerisation network is vital in order to understand the complex dynamics and potential cross-talk involved. Results Phylogeny, protein-protein interactions, protein-DNA interactions and gene expression data have been integrated to provide a comprehensive and up-to-date description of the topology and properties of the nuclear receptor interaction network in humans. We discriminate between DNA-binding and non-DNA-binding dimers, and provide a comprehensive interaction map, that identifies potential cross-talk between the various pathways of nuclear receptors. Conclusion We infer that the topology of this network is hub-based, and much more connected than previously thought. The hub-based topology of the network and the wide tissue expression pattern of NRs create a highly competitive environment for the common heterodimerising partners. Furthermore, a significant number of negative feedback loops is present, with the hub protein SHP [NR0B2] playing a major role. We also compare the evolution, topology and properties of the nuclear receptor network with the hub-based dimerisation network of the bHLH transcription factors in order to identify both unique themes and ubiquitous properties in gene regulation. In terms of methodology, we conclude that such a comprehensive picture can only be assembled by semi-automated text-mining, manual curation and integration of data from various sources.

  4. Hardship is not Hard A survey trip to Wujiang city,a textile business hub in China

    Institute of Scientific and Technical Information of China (English)

    Hu Ying

    2011-01-01

    Recently,it is reported that small and medium sized enterprises in Wujiang,Jiangsu province are in a sad plight,and losses have increased 152% compared with the same period of the previous year.But a trip to Wujiang city,one of China’s textile hubs,finds out that the overall situation is good despite the increased labor cost,financial pressure,and retrenched loans.

  5. Risk management practices in Islamic and conventional banks in Kazakhstan - the Islamic finance hub of the Central Asia

    OpenAIRE

    Kulchmanov, Arman

    2015-01-01

    Purpose - The study explores the risk management and reporting practices in selected Islamic and conventional banks in Kazakhstan, the Islamic finance hub of the Central Asia. The Government of Kazakhstan has planned to transform the economy to a Shari’ah complaint economic system. As risk management is one of the important challenges for banks, this study explores the preparedness of the banking industry in Kazakhstan facing the risk management challenges. Design/methodology/approach – T...

  6. Collaboration Opportunities with the Cancer Human Biobank (caHUB) at NCI | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    The Biorepositories and Biospecimen Research Branch (BBRB) at the National Cancer Institute has developed the Cancer Human Biobank (caHUB), which is a unique infrastructure for collecting biospecimens for the purpose of conducting biospecimen research. Biospecimens from the BPV program will be made available to collaborators with the capability to perform molecular analysis as part of a collaborative research agreement with the NCI-BBRB.

  7. Risk management practices in Islamic and conventional banks in Kazakhstan - the Islamic finance hub of the Central Asia

    OpenAIRE

    Kulchmanov, Arman

    2015-01-01

    Purpose - The study explores the risk management and reporting practices in selected Islamic and conventional banks in Kazakhstan, the Islamic finance hub of the Central Asia. The Government of Kazakhstan has planned to transform the economy to a Shari’ah complaint economic system. As risk management is one of the important challenges for banks, this study explores the preparedness of the banking industry in Kazakhstan facing the risk management challenges. Design/methodology/approach – T...

  8. USDA Climate Hubs - delivering usable information and tools to farmers, ranchers and forest land managers - Communication insights from the Regions

    Science.gov (United States)

    Johnson, R.; Steele, R.

    2016-12-01

    The USDA Climate Hubs were established in 2014 to develop and deliver science-based, region-specific information and technologies, with USDA agencies and partners, to agricultural and natural resource managers to enable climate-informed decision-making. In the two and half years of existence, our regional leads have gained insights into communicating with the agricultural and forestry communities throughout the different regions of the country. Perspectives differ somewhat among regions and sectors. This talk will share those various insights.

  9. Abnormal Intrinsic Functional Hubs in Severe Male Obstructive Sleep Apnea: Evidence from a Voxel-Wise Degree Centrality Analysis

    Science.gov (United States)

    Shao, Yi; Gong, Honghan; Zhang, Wei; Zeng, Xianjun; Ye, Chenglong; Nie, Si; Chen, Liting; Peng, Dechang

    2016-01-01

    Purpose Obstructive sleep apnea (OSA) has been associated with changes in brain structure and regional function in certain brain areas. However, the functional features of network organization in the whole brain remain largely uncertain. The purpose of this study was to identify the OSA-related spatial centrality distribution of the whole brain functional network and to investigate the potential altered intrinsic functional hubs. Methods Forty male patients with newly confirmed severe OSA on polysomnography, and well-matched good sleepers, participated in this study. All participants underwent a resting-state functional MRI scan and clinical and cognitive evaluation. Voxel-wise degree centrality (DC) was measured across the whole brain, and group difference in DC was compared. The relationship between the abnormal DC value and clinical variables was assessed using a linear correlation analysis. Results Remarkably similar spatial distributions of the functional hubs (high DC) were found in both groups. However, OSA patients exhibited a pattern of significantly reduced regional DC in the left middle occipital gyrus, posterior cingulate cortex, left superior frontal gyrus, and bilateral inferior parietal lobule, and DC was increased in the right orbital frontal cortex, bilateral cerebellum posterior lobes, and bilateral lentiform nucleus, including the putamen, extending to the hippocampus, and the inferior temporal gyrus, which overlapped with the functional hubs. Furthermore, a linear correlation analysis revealed that the DC value in the posterior cingulate cortex and left superior frontal gyrus were positively correlated with Montreal cognitive assessment scores, The DC value in the left middle occipital gyrus and bilateral inferior parietal lobule were negatively correlated with apnea-hypopnea index and arousal index in OSA patients. Conclusion Our findings suggest that OSA patients exhibited specific abnormal intrinsic functional hubs including relatively

  10. Scenario-based modeling for multiple allocation hub location problem under disruption risk: multiple cuts Benders decomposition approach

    Science.gov (United States)

    Yahyaei, Mohsen; Bashiri, Mahdi

    2017-03-01

    The hub location problem arises in a variety of domains such as transportation and telecommunication systems. In many real-world situations, hub facilities are subject to disruption. This paper deals with the multiple allocation hub location problem in the presence of facilities failure. To model the problem, a two-stage stochastic formulation is developed. In the proposed model, the number of scenarios grows exponentially with the number of facilities. To alleviate this issue, two approaches are applied simultaneously. The first approach is to apply sample average approximation to approximate the two stochastic problem via sampling. Then, by applying the multiple cuts Benders decomposition approach, computational performance is enhanced. Numerical studies show the effective performance of the SAA in terms of optimality gap for small problem instances with numerous scenarios. Moreover, performance of multi-cut Benders decomposition is assessed through comparison with the classic version and the computational results reveal the superiority of the multi-cut approach regarding the computational time and number of iterations.

  11. A multi-objective optimization model for hub network design under uncertainty: An inexact rough-interval fuzzy approach

    Science.gov (United States)

    Niakan, F.; Vahdani, B.; Mohammadi, M.

    2015-12-01

    This article proposes a multi-objective mixed-integer model to optimize the location of hubs within a hub network design problem under uncertainty. The considered objectives include minimizing the maximum accumulated travel time, minimizing the total costs including transportation, fuel consumption and greenhouse emissions costs, and finally maximizing the minimum service reliability. In the proposed model, it is assumed that for connecting two nodes, there are several types of arc in which their capacity, transportation mode, travel time, and transportation and construction costs are different. Moreover, in this model, determining the capacity of the hubs is part of the decision-making procedure and balancing requirements are imposed on the network. To solve the model, a hybrid solution approach is utilized based on inexact programming, interval-valued fuzzy programming and rough interval programming. Furthermore, a hybrid multi-objective metaheuristic algorithm, namely multi-objective invasive weed optimization (MOIWO), is developed for the given problem. Finally, various computational experiments are carried out to assess the proposed model and solution approaches.

  12. A modified NSGA-II solution for a new multi-objective hub maximal covering problem under uncertain shipments

    Science.gov (United States)

    Ebrahimi Zade, Amir; Sadegheih, Ahmad; Lotfi, Mohammad Mehdi

    2014-07-01

    Hubs are centers for collection, rearrangement, and redistribution of commodities in transportation networks. In this paper, non-linear multi-objective formulations for single and multiple allocation hub maximal covering problems as well as the linearized versions are proposed. The formulations substantially mitigate complexity of the existing models due to the fewer number of constraints and variables. Also, uncertain shipments are studied in the context of hub maximal covering problems. In many real-world applications, any link on the path from origin to destination may fail to work due to disruption. Therefore, in the proposed bi-objective model, maximizing safety of the weakest path in the network is considered as the second objective together with the traditional maximum coverage goal. Furthermore, to solve the bi-objective model, a modified version of NSGA-II with a new dynamic immigration operator is developed in which the accurate number of immigrants depends on the results of the other two common NSGA-II operators, i.e. mutation and crossover. Besides validating proposed models, computational results confirm a better performance of modified NSGA-II versus traditional one.

  13. From “Comprehensive Transportation Hub” to “City New Sitting Room”---Overall the design about Jinan East district comprehensive transportation hub

    Science.gov (United States)

    Lv, Jie; Guo, Jianmin; Li, Jin

    2017-08-01

    integrated transport hub or high-speed rail station often talked about, often known as the “city portal” and the title of “city window”, so the comprehensive transportation hub or the high-speed rail station of a city is very important to a region or a provincial. At the same time, it reflects that the managers and users of a city only focus on the comprehensive transportation hub of transportation service function and ignore her cities attributes and functions. Jinan east district comprehensive transportation hub in the beginning of design is given a feature that it has to serve both the traffic and city. We are trying to build a new center for Jinan east new town, the window to welcome people, the city hall of hospitality.

  14. The Italian Hub of Population Biobanks as a potential tool for improving public health stewardship.

    Science.gov (United States)

    Bravo, Elena; Napolitano, Mariarosaria; Santoro, Filippo; Belardelli, Filippo; Federic, Antonio

    2013-06-01

    In Italy, a country that is experiencing the decentralization of health services from central to regional level of government, the Minister of Health is proposing stewardship as a model of governance for the public health system. Stewardship favors efficiency in the policy decision-making process, based on reciprocal trust, and tends to be more ethical. The embryonic proposal to test stewardship in the field of population-based research was advanced during the launching conference Challenges and Opportunities of the Italian Hub of Population Biobanks (HIBP) held in 2012 in Rome. Resources collected by population biobanks (i.e., blood and its derivatives, and/or DNA isolated from any type of biological samples and relative associated data) have, in fact, a recognized scientific value for the investigation of links between genetics, health and life style, and epidemiological outcomes through population biobank-based studies, and are essential to planning effective and qualified interventions for public health. The current economic crisis requires a strong push to rationalize investment in health policies. In particular, population biobank-based studies require financial commitment, often of long duration, for the realization of their goals. Thus, innovative solutions to allow fast integration of scientific knowledge into political health strategy are required. During the conference in Rome, it was proposed to test the stewardship model by its application to the inter-relationship between population biobank-based studies and disease prevention. Stewardship minimizes barriers to innovation and uses information more effectively to better develop new strategies for prevention and/or treatment. In the months following the conference, the proposal was defined more clearly, and the HIBP network became a potential tool for testing and implementing this model in the Italian Public Health prevention system.

  15. Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour.

    Science.gov (United States)

    Bonnavion, Patricia; Mickelsen, Laura E; Fujita, Akie; de Lecea, Luis; Jackson, Alexander C

    2016-11-15

    The hypothalamus is among the most phylogenetically conserved regions in the vertebrate brain, reflecting its critical role in maintaining physiological and behavioural homeostasis. By integrating signals arising from both the brain and periphery, it governs a litany of behaviourally important functions essential for survival. In particular, the lateral hypothalamic area (LHA) is central to the orchestration of sleep-wake states, feeding, energy balance and motivated behaviour. Underlying these diverse functions is a heterogeneous assembly of cell populations typically defined by neurochemical markers, such as the well-described neuropeptides hypocretin/orexin and melanin-concentrating hormone. However, anatomical and functional evidence suggests a rich diversity of other cell populations with complex neurochemical profiles that include neuropeptides, receptors and components of fast neurotransmission. Collectively, the LHA acts as a hub for the integration of diverse central and peripheral signals and, through complex local and long-range output circuits, coordinates adaptive behavioural responses to the environment. Despite tremendous progress in our understanding of the LHA, defining the identity of functionally discrete LHA cell types, and their roles in driving complex behaviour, remain significant challenges in the field. In this review, we discuss advances in our understanding of the neurochemical and cellular heterogeneity of LHA neurons and the recent application of powerful new techniques, such as opto- and chemogenetics, in defining the role of LHA circuits in feeding, reward, arousal and stress. From pioneering work to recent developments, we review how the interrogation of LHA cells and circuits is contributing to a mechanistic understanding of how the LHA coordinates complex behaviour.

  16. Delineating function and connectivity of optokinetic hubs in the cerebellum and the brainstem.

    Science.gov (United States)

    Ruehl, Ria Maxine; Hinkel, Carolin; Bauermann, Thomas; Eulenburg, Peter Zu

    2017-06-23

    Optokinetic eye movements are crucial for keeping a stable image on the retina during movements of the head. These eye movements can be differentiated into a cortically generated response (optokinetic look nystagmus) and the highly reflexive optokinetic stare nystagmus, which is controlled by circuits in the brainstem and cerebellum. The contributions of these infratentorial networks and their functional connectivity with the cortical eye fields are still poorly understood in humans. To map ocular motor centres in the cerebellum and brainstem, we studied stare nystagmus using small-field optokinetic stimuli in the horizontal and vertical directions in 22 healthy subjects. We were able to differentiate ocular motor areas of the pontine brainstem and midbrain in vivo for the first time. Direction and velocity-dependent activations were found in the pontine brainstem (nucleus reticularis, tegmenti pontis, and paramedian pontine reticular formation), the uvula, flocculus, and cerebellar tonsils. The ocular motor vermis, on the other hand, responded to constant and accelerating velocity stimulation. Moreover, deactivation patterns depict a governing role for the cerebellar tonsils in ocular motor control. Functional connectivity results of these hubs reveal the close integration of cortico-cerebellar ocular motor and vestibular networks in humans. Adding to the cortical concept of a right-hemispheric predominance for visual-spatial processing, we found a complementary left-sided cerebellar dominance for our ocular motor task. A deeper understanding of the role of the cerebellum and especially the cerebellar tonsils for eye movement control in a clinical context seems vitally important and is now feasible with functional neuroimaging.

  17. SensorWeb Hub infrastructure for open access to scientific research data

    Science.gov (United States)

    de Filippis, Tiziana; Rocchi, Leandro; Rapisardi, Elena

    2015-04-01

    The sharing of research data is a new challenge for the scientific community that may benefit from a large amount of information to solve environmental issues and sustainability in agriculture and urban contexts. Prerequisites for this challenge is the development of an infrastructure that ensure access, management and preservation of data, technical support for a coordinated and harmonious management of data that, in the framework of Open Data Policies, should encourages the reuse and the collaboration. The neogeography and the citizen as sensors approach, highlight that new data sources need a new set of tools and practices so to collect, validate, categorize, and use / access these "crowdsourced" data, that integrate the data sets produced in the scientific field, thus "feeding" the overall available data for analysis and research. When the scientific community embraces the dimension of collaboration and sharing, access and re-use, in order to accept the open innovation approach, it should redesign and reshape the processes of data management: the challenges of technological and cultural innovation, enabled by web 2.0 technologies, bring to the scenario where the sharing of structured and interoperable data will constitute the unavoidable building block to set up a new paradigm of scientific research. In this perspective the Institute of Biometeorology, CNR, whose aim is contributing to sharing and development of research data, has developed the "SensorWebHub" (SWH) infrastructure to support the scientific activities carried out in several research projects at national and international level. It is designed to manage both mobile and fixed open source meteorological and environmental sensors, in order to integrate the existing agro-meteorological and urban monitoring networks. The proposed architecture uses open source tools to ensure sustainability in the development and deployment of web applications with geographic features and custom analysis, as requested

  18. Hub and spoke model: making rural healthcare in India affordable, available and accessible.

    Science.gov (United States)

    Devarakonda, Srichand

    2016-01-01

    Quality health care should be within everyone's reach, especially in a developing country. While India has the largest private health sector in the world, only one-fifth of healthcare expenditure is publically financed; it is mostly an out-of-pocket expense. About 70% of Indians live in rural areas making about $3 per day, and a major portion of that goes towards food and shelter and, thus, not towards health care. Transportation facilities in rural India are poor, making access to medical facilities difficult, and infrastructure facilities are minimal, making the available medical care insufficient. The challenge presented to India was to provide health care that was accessible, available and affordable to people in rural areas and the low-income bracket. The intent of this article is to determine whether the hub and spoke model (HSM), when implemented in the healthcare industry, can expand the market reach and increase profits while reducing costs of operations for organizations and, thereby, cost to customers. This article also discusses the importance of information and communications technologies (ICT) in the HSM approach, which the handful of published articles in this topic have failed to discuss. This article opts for an exploratory study, including review of published literature, web articles, viewpoints of industry experts, published journals, and in-depth interviews. This article will discuss how and why the HSM works in India's healthcare industry while isolating its strengths and weaknesses, and analyzing the impact of India's success. India's HSM implementation has become a paramount example of an acceptable model that, while exceeding the needs and expectations of its patients, is cost-effective and has obtained operational and health-driven results. Despite being an emerging nation, India takes the top spot in terms of affordability of ICT as well as for having the highest number of computer-literate graduates and healthcare workers in the world

  19. Structural dysconnectivity of key cognitive and emotional hubs in young people at high genetic risk for bipolar disorder.

    Science.gov (United States)

    Roberts, G; Perry, A; Lord, A; Frankland, A; Leung, V; Holmes-Preston, E; Levy, F; Lenroot, R K; Mitchell, P B; Breakspear, M

    2016-12-20

    Emerging evidence suggests that psychiatric disorders are associated with disturbances in structural brain networks. Little is known, however, about brain networks in those at high risk (HR) of bipolar disorder (BD), with such disturbances carrying substantial predictive and etiological value. Whole-brain tractography was performed on diffusion-weighted images acquired from 84 unaffected HR individuals with at least one first-degree relative with BD, 38 young patients with BD and 96 matched controls (CNs) with no family history of mental illness. We studied structural connectivity differences between these groups, with a focus on highly connected hubs and networks involving emotional centres. HR participants showed lower structural connectivity in two lateralised sub-networks centred on bilateral inferior frontal gyri and left insular cortex, as well as increased connectivity in a right lateralised limbic sub-network compared with CN subjects. BD was associated with weaker connectivity in a small right-sided sub-network involving connections between fronto-temporal and temporal areas. Although these sub-networks preferentially involved structural hubs, the integrity of the highly connected structural backbone was preserved in both groups. Weaker structural brain networks involving key emotional centres occur in young people at genetic risk of BD and those with established BD. In contrast to other psychiatric disorders such as schizophrenia, the structural core of the brain remains intact, despite the local involvement of network hubs. These results add to our understanding of the neurobiological correlates of BD and provide predictions for outcomes in young people at high genetic risk for BD.Molecular Psychiatry advance online publication, 20 December 2016; doi:10.1038/mp.2016.216.

  20. 大型综合交通枢纽建设思考%Considerations about a Comprehensive Traffic Hub Construction

    Institute of Scientific and Technical Information of China (English)

    李筱毅; 潘威

    2012-01-01

    以城市轨道交通为主、多重交通运输方式为辅,联结空港、码头、高铁车站及汽车长途客运站等大客流运输节点所形成的大型综合交通枢纽在我国逐步出现,但相关规划、设计、建设等方面的探索仍处于起步阶段.以深圳市已建成或在建的3个大型综合交通枢纽为基础,从规划定位、功能用途、建设过程和对城市发展影响等方面进行介绍与探讨,提出建设此类投资巨大、功能庞杂、影响深远的大型综合交通枢纽时,在规划、设计、施工等方面应予以重点关注的问题.%Mega transport hubs are increasingly constructed in China which comprise many types of transport means such as the urban rail transit, airport, harbor, bullet train station and coach station. However, strategies of their planning, design and construction lag behind the rapid growth of these projects. Based on three large-scale comprehensive traffic hubs built or under construction in Shenzhen city, the paper elaborates and discusses their phming-orientation, functions, construction process and impact on city development and puts forward issues to be emphatically addressed in planning, design and construction for such comprehensive large traffic hubs of big investment, with complex functions and far-reaching influence.

  1. Providing farmers, ranchers, and foresters in California with actionable climate information: opportunities and obstacles for California's USDA Regional Climate Sub Hub

    Science.gov (United States)

    Kerr, A. C.; Steenwerth, K. L.; Stine, P.; Chambers, J.; Fischer, C.; Kiger, L.; Hedt, T.; Gonzales, O.; Tse, R.; Tse, A.; Gunasekara, A.; Henly, R.; DeLaRosa, J.; Battany, M.; Pathak, T.; Parker, D.; Schwartz, M.; Tjeerdema, R.; Kalansky, J.; Kehmeier, E.; Xides, A.; Marshall, A.; Jagannathan, K.

    2015-12-01

    California is the #1 agricultural state in the US, with output worth $50 billion in 2014. California produces half the nation's specialty crops (fruits, vegetables, and nuts) and is a leader in beef and dairy production. California also has 10% of the forestland west of the Mississippi, including many economically and ecologically important forest types. The USDA Regional Climate Sub Hub for California was created in 2014 to help land users (farmers, ranchers, and forest land owners) cope with climate variability and change, via two-way linkages with producers of climate information. In its first year and a half, the Sub Hub has formed partnerships with California's many other climate-focused organizations, including state and federal government, universities, and NGOs. The Sub Hub coordinates climate-related work among several USDA agencies (ARS, FS, NRCS, and others), which formerly had no mechanism to do so. The Sub Hub also works with other federal climate programs (such as the DOI's CA Landscape Conservation Cooperative, with which the Sub Hub is engaged in a multi-year assessment to balance conservation and agriculture in the Central Valley). State government agencies, such as the Natural Resources Agency and the Department of Food and Agriculture, are key partners for priority-setting and data-sharing. One of the Sub Hub's crucial synergies is with UC Cooperative Extension, which provides insight into land users' needs and provides an outlet to deliver Sub Hub products on the ground. In response to stakeholder concerns, the Sub Hub's 2015-16 emphasis is the ongoing California drought. The Sub Hub's current stakeholder-focused projects include (1) a climate vulnerability assessment of California rangelands, including detailed maps of likely vegetation change and suggestions for location-specific adaptation options; (2) a comprehensive climate-related update of Cooperative Extension's widely used Forest Stewardship Series for private landowners; (3) a study on

  2. Supply -Hub 与 Milk -Run 集成模式下利益分配问题研究%Benefits Distribution Research of the Supply Chain Based on Integrated mode of Supply Hub and Milk -Run

    Institute of Scientific and Technical Information of China (English)

    杨阳; 付海民; 刘凡

    2014-01-01

    文中基于 Shapley 值的利益初步分配结果,充分考虑 Supply -Hub 与 Milk -Run 集成模式下利益分配主体的风险承担、努力水平、物流准时化能力三个因素,运用层次分析与模糊综合评价相结合的方法得出一个利益分配综合修正因子,对初步分配结果进行修正得出最终利益分配结果。%Based on the analysis of the existing distribution model and the method of profit distribution,then allocate the interests of the different subjects with a method of Shapley value improved by AHP and Fuzzy Synthetic Evaluation,which makes the profit distribution more practically,and ensure the implementation of supply chain cooperation and sustainable development. The conclusion of the paper provide ideas and Suggestions to the operation and profit distribution of Supply -Hub and Milk -Run integrated mode Supply chain,and provide reference for assembly manufacturing enterprise to cooperate well with the logistics providers.

  3. Effect of rotor configuration on guyed tower and foundation designs and estimated costs for intermediate site horizontal axis wind turbines

    Science.gov (United States)

    Frederick, G. R.; Winemiller, J. R.; Savino, J. M.

    1982-01-01

    Three designs of a guyed cylindrical tower and its foundation for an intermediate size horizontal axis wind turbine generator are discussed. The primary difference in the three designs is the configuration of the rotor. Two configurations are two-blade rotors with teetering hubs - one with full span pitchable blades, the other with fixed pitch blades. The third configuration is a three-bladed rotor with a rigid hub and fixed pitch blades. In all configurations the diameter of the rotor is 38 meters and the axis of rotation is 30.4 meters above grade, and the power output is 200 kW and 400 kW. For each configuration the design is based upon for the most severe loading condition either operating wind or hurricane conditions. The diameter of the tower is selected to be 1.5 meters (since it was determined that this would provide sufficient space for access ladders within the tower) with guy rods attached at 10.7 meters above grade. Completing a design requires selecting the required thicknesses of the various cylindrical segments, the number and diameter of the guy rods, the number and size of soil anchors, and the size of the central foundation. The lower natural frequencies of vibration are determined for each design to ensure that operation near resonance does not occur. Finally, a cost estimate is prepared for each design. A preliminary design and cost estimate of a cantilever tower (cylindrical and not guyed) and its foundation is also presented for each of the three configurations.

  4. A Three-Legged Stool or Race? Governance Models for NOAA RISAs, DOI CSCs, and USDA Climate Hub

    Science.gov (United States)

    Foster, J. G.

    2014-12-01

    NOAAs Regional Integrated Sciences and Assessments (RISA) Teams, DOIs Climate Science Centers (CSCs), and USDAs Regional Climate Hubs (RCHs) have common missions of integrating climate and related knowledge across scientific disciplines and regions to create "actionable" information that decision-makes can use to manage climate risks and impacts at state and local scales. However, the sponsoring agency programs, university investigators, and local federal officials govern each differently. The three models of program and center governance are 1) exclusively university (RISAs), 2) a hybrid of Federal government and (host) university (CSCs,), and 3) exclusively Federal (Hubs). Each model has it's advantages and disadvantages in terms of legal definition and authority, scientific mission requirements and strategies, flexibility and legitimacy to conduct research and to collaborate regionally with constituencies, leadership and governance approach and "friction points,", staff capacity and ability to engage stakeholders, necessity to deliver products and services, bureaucratic oversight, performance evaluation, and political support at Congressional, state, and local levels. Using available sources of information and data, this paper will compare and contrast the strengths and weakness of these three regional applied climate science center governance models.

  5. A Three-Legged Stool or Race? Governance Models for NOAA RISAs, DOI CSCs, and USDA Climate Hubs

    Science.gov (United States)

    Foster, J. G.

    2014-12-01

    NOAAs Regional Integrated Sciences and Assessments (RISA) Teams, DOIs Climate Science Centers (CSCs), and USDAs Regional Climate Hubs (RCHs) have common missions of integrating climate and related knowledge across scientific disciplines and regions to create "actionable" information that decision-makes can use to manage climate risks and impacts at state and local scales. However, the sponsoring agency programs, university investigators, and local federal officials govern each differently. The three models of program and center governance are 1) exclusively university (RISAs), 2) a hybrid of Federal government and (host) university (CSCs,), and 3) exclusively Federal (Hubs). Each model has it's advantages and disadvantages in terms of legal definition and authority, scientific mission requirements and strategies, flexibility and legitimacy to conduct research and to collaborate regionally with constituencies, leadership and governance approach and "friction points,", staff capacity and ability to engage stakeholders, necessity to deliver products and services, bureaucratic oversight, performance evaluation, and political support at Congressional, state, and local levels. Using available sources of information and data, this paper will compare and contrast the strengths and weakness of these three regional applied climate science center governance models.

  6. Global connectivity of hub residues in Oncoprotein structures encodes genetic factors dictating personalized drug response to targeted Cancer therapy

    Science.gov (United States)

    Soundararajan, Venky; Aravamudan, Murali

    2014-12-01

    The efficacy and mechanisms of therapeutic action are largely described by atomic bonds and interactions local to drug binding sites. Here we introduce global connectivity analysis as a high-throughput computational assay of therapeutic action - inspired by the Google page rank algorithm that unearths most ``globally connected'' websites from the information-dense world wide web (WWW). We execute short timescale (30 ps) molecular dynamics simulations with high sampling frequency (0.01 ps), to identify amino acid residue hubs whose global connectivity dynamics are characteristic of the ligand or mutation associated with the target protein. We find that unexpected allosteric hubs - up to 20Å from the ATP binding site, but within 5Å of the phosphorylation site - encode the Gibbs free energy of inhibition (ΔGinhibition) for select protein kinase-targeted cancer therapeutics. We further find that clinically relevant somatic cancer mutations implicated in both drug resistance and personalized drug sensitivity can be predicted in a high-throughput fashion. Our results establish global connectivity analysis as a potent assay of protein functional modulation. This sets the stage for unearthing disease-causal exome mutations and motivates forecast of clinical drug response on a patient-by-patient basis. We suggest incorporation of structure-guided genetic inference assays into pharmaceutical and healthcare Oncology workflows.

  7. Identification of hub genes of pneumocyte senescence induced by thoracic irradiation using weighted gene co-expression network analysis

    Science.gov (United States)

    XING, YONGHUA; ZHANG, JUNLING; LU, LU; LI, DEGUAN; WANG, YUEYING; HUANG, SONG; LI, CHENGCHENG; ZHANG, ZHUBO; LI, JIANGUO; MENG, AIMIN

    2016-01-01

    Irradiation commonly causes pneumocyte senescence, which may lead to severe fatal lung injury characterized by pulmonary dysfunction and respiratory failure. However, the molecular mechanism underlying the induction of pneumocyte senescence by irradiation remains to be elucidated. In the present study, weighted gene co-expression network analysis (WGCNA) was used to screen for differentially expressed genes, and to identify the hub genes and gene modules, which may be critical for senescence. A total of 2,916 differentially expressed genes were identified between the senescence and non-senescence groups following thoracic irradiation. In total, 10 gene modules associated with cell senescence were detected, and six hub genes were identified, including B-cell scaffold protein with ankyrin repeats 1, translocase of outer mitochondrial membrane 70 homolog A, actin filament-associated protein 1, Cd84, Nuf2 and nuclear factor erythroid 2. These genes were markedly associated with cell proliferation, cell division and cell cycle arrest. The results of the present study demonstrated that WGCNA of microarray data may provide further insight into the molecular mechanism underlying pneumocyte senescence. PMID:26572216

  8. Numerical simulation and experimental study for the die forging process of a high-speed railway brake disc hub

    Science.gov (United States)

    Sun, Mingyue; Xu, Bin; Zhang, Long; LI, Dianzhong

    2013-05-01

    With the aim of manufacturing a near-net shape forging product of a brake disk hub for the high-speed railway, the die forging process was designed and optimized in this study. Firstly, based on the measured stress-strain curves at different strain rates and the thermal-physical parameters of 40Cr A steel, a finite element model for the forging process of a high-speed railway brake disc hub was established. Then, the temperature, stress and strain fields were studied and analyzed at the pre-forging and the finial-forging stages. Besides, in order to trace the stress and strain evolution, five points at different positions were chosen on the billet, and the comparison of the state conditions was made among these points. The results have demonstrated that the product can be well formed by an elaborately designed three-stage forging process, which may reduce the metal machine allowance and the producing cost effectively. Finally, an industrial trial was made and a machined product with sound quality was obtained.

  9. Arabidopsis GERANYLGERANYL DIPHOSPHATE SYNTHASE 11 is a hub isozyme required for the production of most photosynthesis-related isoprenoids.

    Science.gov (United States)

    Ruiz-Sola, M Águila; Coman, Diana; Beck, Gilles; Barja, M Victoria; Colinas, Maite; Graf, Alexander; Welsch, Ralf; Rütimann, Philipp; Bühlmann, Peter; Bigler, Laurent; Gruissem, Wilhelm; Rodríguez-Concepción, Manuel; Vranová, Eva

    2016-01-01

    Most plastid isoprenoids, including photosynthesis-related metabolites such as carotenoids and the side chain of chlorophylls, tocopherols (vitamin E), phylloquinones (vitamin K), and plastoquinones, derive from geranylgeranyl diphosphate (GGPP) synthesized by GGPP synthase (GGPPS) enzymes. Seven out of 10 functional GGPPS isozymes in Arabidopsis thaliana reside in plastids. We aimed to address the function of different GGPPS paralogues for plastid isoprenoid biosynthesis. We constructed a gene co-expression network (GCN) using GGPPS paralogues as guide genes and genes from the upstream and downstream pathways as query genes. Furthermore, knock-out and/or knock-down ggpps mutants were generated and their growth and metabolic phenotypes were analyzed. Also, interacting protein partners of GGPPS11 were searched for. Our data showed that GGPPS11, encoding the only plastid isozyme essential for plant development, functions as a hub gene among GGPPS paralogues and is required for the production of all major groups of plastid isoprenoids. Furthermore, we showed that the GGPPS11 protein physically interacts with enzymes that use GGPP for the production of carotenoids, chlorophylls, tocopherols, phylloquinone, and plastoquinone. GGPPS11 is a hub isozyme required for the production of most photosynthesis-related isoprenoids. Both gene co-expression and protein-protein interaction likely contribute to the channeling of GGPP by GGPPS11. © 2015 The Authors. New Phytologist © 2015 New Phytologist Trust.

  10. PGVL Hub: An integrated desktop tool for medicinal chemists to streamline design and synthesis of chemical libraries and singleton compounds.

    Science.gov (United States)

    Peng, Zhengwei; Yang, Bo; Mattaparti, Sarathy; Shulok, Thom; Thacher, Thomas; Kong, James; Kostrowicki, Jaroslav; Hu, Qiyue; Na, James; Zhou, Joe Zhongxiang; Klatte, David; Chao, Bo; Ito, Shogo; Clark, John; Sciammetta, Nunzio; Coner, Bob; Waller, Chris; Kuki, Atsuo

    2011-01-01

    PGVL Hub is an integrated molecular design desktop tool that has been developed and globally deployed throughout Pfizer discovery research units to streamline the design and synthesis of combinatorial libraries and singleton compounds. This tool supports various workflows for design of singletons, combinatorial libraries, and Markush exemplification. It also leverages the proprietary PGVL virtual space (which contains 10(14) molecules spanned by experimentally derived synthesis protocols and suitable reactants) for lead idea generation, lead hopping, and library design. There had been an intense focus on ease of use, good performance and robustness, and synergy with existing desktop tools such as ISIS/Draw and SpotFire. In this chapter we describe the three-tier enterprise software architecture, key data structures that enable a wide variety of design scenarios and workflows, major technical challenges encountered and solved, and lessons learned during its development and deployment throughout its production cycles. In addition, PGVL Hub represents an extendable and enabling platform to support future innovations in library and singleton compound design while being a proven channel to deliver those innovations to medicinal chemists on a global scale.

  11. DisasterHub: A mobile application for enabling crowd generated data fusion in Earth Observation disaster management services

    Science.gov (United States)

    Tsironis, Vassilis; Herekakis, Themistocles; Tsouni, Alexia; Kontoes, Charalampos Haris

    2016-04-01

    by DisasterHub, an application proposal that won the MYGEOSS Second Call for Innovative Apps (http://beyond-eocenter.eu/index.php/ann-blog/197-disasterhub-mygeoss). DisasterHub will fill the gap by introducing a mobile application that will act as a middleware between mobile users and BEYOND services, building on the concept of citizen observatories in support of Copernicus, GEO, GEOSS, and UN-SPIDER. In this context the roadmap for generating beneficial EO services through DisasterHub is sketched in two main branches: (i) ingestion, processing and fusion of big multimodal data with additional spatiotemporal evidences (originated from Core Copernicus, GEO, GEOSS) for deriving higher value DRR and EMS products, (ii) interlinking the web and mobile platforms for the exchange and ease access of the societies to open EO/crowd generated data. The benefited communities will be effectively enlarged through DisasterHub mobile app. Mutually the BEYOND ecosystem will profit from the large amount of tagged information returned from the field, forming a unique input to the production chains and assimilation of predictive modeling. In conclusion DisasterHub will showcase in the EO community an enhanced EO services ecosystem with a software infrastructure for easy access of mobile users to the real-time monitoring and early-warning systems of BEYOND and tools for incorporating crowd-sourced data with open geospatial and socioeconomic data via open/linked data ingestion mechanisms (APIs), retrieved from the GEOSS Data-CORE, Copernicus and other EU portals.

  12. Final Report for Project: Impacts of stratification and non-equilibrium winds and waves on hub-height winds

    Energy Technology Data Exchange (ETDEWEB)

    Patton, Edward G. [Univ. Corporation for Atmospheric Research, Boulder, CO (United States)

    2015-07-14

    This project used a combination of turbulence-resolving large-eddy simulations, single-column modeling (where turbulence is parameterized), and currently available observations to improve, assess, and develop a parameterization of the impact of non-equilibrium wave states and stratification on the buoy-observed winds to establish reliable wind data at the turbine hub-height level. Analysis of turbulence-resolving simulations and observations illuminates the non-linear coupling between the atmosphere and the undulating sea surface. This analysis guides modification of existing boundary layer parameterizations to include wave influences for upward extrapolation of surface-based observations through the turbine layer. Our surface roughness modifications account for the interaction between stratification and the effects of swell’s amplitude and wavelength as well as swell’s relative motion with respect to the mean wind direction. The single-column version of the open source Weather and Research Forecasting (WRF) model (Skamarock et al., 2008) serves as our platform to test our proposed planetary boundary layer parameterization modifications that account for wave effects on marine atmospheric boundary layer flows. WRF has been widely adopted for wind resource analysis and forecasting. The single column version is particularly suitable to development, analysis, and testing of new boundary layer parameterizations. We utilize WRF’s single-column version to verify and validate our proposed modifications to the Mellor-Yamada-Nakanishi-Niino (MYNN) boundary layer parameterization (Nakanishi and Niino, 2004). We explore the implications of our modifications for two-way coupling between WRF and wave models (e.g.,Wavewatch III). The newly implemented parameterization accounting for marine atmospheric boundary layer-wave coupling is then tested in three-dimensional WRF simulations at grid sizes near 1 km. These simulations identify the behavior of simulated winds at the

  13. Systems biology approach to transplant tolerance: proof of concept experiments using RNA interference (RNAi) to knock down hub genes in Jurkat and HeLa cells in vitro.

    Science.gov (United States)

    Lwin, Wint Wah; Park, Ken; Wauson, Matthew; Gao, Qin; Finn, Patricia W; Perkins, David; Khanna, Ajai

    2012-07-01

    Systems biology is gaining importance in studying complex systems such as the functional interconnections of human genes [1]. To investigate the molecular interactions involved in T cell immune responses, we used databases of physical gene-gene interactions to constructed molecular interaction networks (interconnections) with R language algorithms. This helped to identify highly interconnected "hub" genes AT(1)P5C1, IL6ST, PRKCZ, MYC, FOS, JUN, and MAPK1. We hypothesized that suppression of these hub genes in the gene network would result in significant phenotypic effects on T cells and examined this in vitro. The molecular interaction networks were then analyzed and visualized with Cytoscape. Jurkat and HeLa cells were transfected with siRNA for the selected hub genes. Cell proliferation was measured using ATP luminescence and BrdU labeling, which were measured 36, 72, and 96 h after activation. Following T cell stimulation, we found a significant decrease in ATP production (P cells. However, HeLa cells showed a significant (P cell proliferation when the genes MAPK1, IL6ST, ATP5C1, JUN, and FOS were knocked down. In both Jurkat and HeLa cells, targeted gene knockdown using siRNA showed decreased cell proliferation and ATP production in both Jurkat and HeLa cells. However, Jurkat T cells and HELA cells use different hub genes to regulate activation responses. This experiment provides proof of principle of applying siRNA knockdown of T cell hub genes to evaluate their proliferative capacity and ATP production. This novel concept outlines a systems biology approach to identify hub genes for targeted therapeutics. Published by Elsevier Inc.

  14. Hub Height Ocean Winds over the North Sea Observed by the NORSEWInD Lidar Array: Measuring Techniques, Quality Control and Data Management

    DEFF Research Database (Denmark)

    Hasager, Charlotte Bay; Stein, Detlef; Courtney, Michael

    2013-01-01

    In the North Sea, an array of wind profiling wind lidars were deployed mainly on offshore platforms. The purpose was to observe free stream winds at hub height. Eight lidars were validated prior to offshore deployment with observations from cup anemometers at 60, 80, 100 and 116 m on an onshore met....... The flow distortion around platforms was examined using wind tunnel experiments and computational fluid dynamics and it was found that at 100 m height wind observations by the lidars were not significantly influenced by flow distortion. Observations of the vertical wind profile shear exponent at hub height...

  15. Test Data Report, Low-Speed Wind Tunnel Drag Test of a 2/5 Scale Lockheed AH-56 Cheyenne Door-Hinge Hub

    Science.gov (United States)

    2016-07-01

    SPECIAL REPORT RDMR-AD-16-03 TEST DATA REPORT, LOW-SPEED WIND TUNNEL DRAG TEST OF A 2/5 SCALE LOCKHEED AH-56 CHEYENNE DOOR-HINGE HUB Robert D...TYPE AND DATES COVERED Final 4. TITLE AND SUBTITLE Test Data Report, Low-Speed Wind Tunnel Drag Test of a 2/5 Scale Lockheed AH-56 Cheyenne...Research, Development and Engineering Center (AMRDEC) conducted a drag test of a non-rotating 2/5 scale Lockheed AH-56 Cheyenne main rotor hub in

  16. Final Report for Project: Impacts of stratification and non-equilibrium winds and waves on hub-height winds

    Energy Technology Data Exchange (ETDEWEB)

    Patton, Edward G. [Univ. Corporation for Atmospheric Research, Boulder, CO (United States)

    2015-07-14

    This project used a combination of turbulence-resolving large-eddy simulations, single-column modeling (where turbulence is parameterized), and currently available observations to improve, assess, and develop a parameterization of the impact of non-equilibrium wave states and stratification on the buoy-observed winds to establish reliable wind data at the turbine hub-height level. Analysis of turbulence-resolving simulations and observations illuminates the non-linear coupling between the atmosphere and the undulating sea surface. This analysis guides modification of existing boundary layer parameterizations to include wave influences for upward extrapolation of surface-based observations through the turbine layer. Our surface roughness modifications account for the interaction between stratification and the effects of swell’s amplitude and wavelength as well as swell’s relative motion with respect to the mean wind direction. The single-column version of the open source Weather and Research Forecasting (WRF) model (Skamarock et al., 2008) serves as our platform to test our proposed planetary boundary layer parameterization modifications that account for wave effects on marine atmospheric boundary layer flows. WRF has been widely adopted for wind resource analysis and forecasting. The single column version is particularly suitable to development, analysis, and testing of new boundary layer parameterizations. We utilize WRF’s single-column version to verify and validate our proposed modifications to the Mellor-Yamada-Nakanishi-Niino (MYNN) boundary layer parameterization (Nakanishi and Niino, 2004). We explore the implications of our modifications for two-way coupling between WRF and wave models (e.g.,Wavewatch III). The newly implemented parameterization accounting for marine atmospheric boundary layer-wave coupling is then tested in three-dimensional WRF simulations at grid sizes near 1 km. These simulations identify the behavior of simulated winds at the

  17. Yaw control for active damping of structural dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Ekelund, T. [Chalmers Univ. of Technology, Goeteborg (Sweden). Control Engineering Lab.

    1996-12-01

    Yaw torque control for reduction of structural dynamic loads in a two-bladed wind turbine is investigated. The models are obtained using rigid-body mechanics. Linear quadratic control theory is utilized for design and analysis. The analysis of two simple examples, where the teeter angle and the tower lateral bending motion are regarded, shows that a time-varying controller has some advantages compared with a time-invariant controller. 6 refs, 9 figs

  18. Contact Mechanics: Modeling the Interaction Between Surfaces with Nanoscale Asperities for MEMS via Online Simulations in NanoHUB

    Directory of Open Access Journals (Sweden)

    Petros Charalambides

    2012-01-01

    Full Text Available Physics-based simulations are playing an increasingly important role in materials and device engineering, providing information that can help engineers understand current technology and optimize designs. We describe a model and simulation tool for the characterization of the interaction between surfaces with nanoscale asperities relevant in nano and micro-electromechanical systems (N/MEMS whose operation involves periodic contacts. A mesoscale contact model was developed to characterize the interaction and adhesion between two surfaces in terms of surface topography and fundamental materials properties. The model computed the long-range van der Waals attractive forces and repulsive interactions originating from the contact between solid surface asperities. The tool has been deployed in nanoHUB.org and is available for fully interactive, free online simulations using a web browser.

  19. Analytical Formulation for Sizing and Estimating the Dimensions and Weight of Wind Turbine Hub and Drivetrain Components

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Y. [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Parsons, T. [National Renewable Energy Laboratory (NREL), Golden, CO (United States); King, R. [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Dykes, K. [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Veers, P. [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2015-06-09

    This report summarizes the theory, verification, and validation of a new sizing tool for wind turbine drivetrain components, the Drivetrain Systems Engineering (DriveSE) tool. DriveSE calculates the dimensions and mass properties of the hub, main shaft, main bearing(s), gearbox, bedplate, transformer if up-tower, and yaw system. The level of fi¬ delity for each component varies depending on whether semiempirical parametric or physics-based models are used. The physics-based models have internal iteration schemes based on system constraints and design criteria. Every model is validated against available industry data or finite-element analysis. The verification and validation results show that the models reasonably capture primary drivers for the sizing and design of major drivetrain components.

  20. Managing Transportation Megaproject Schedule Risks Using Structural Equation Modelling: A Case Study of Shanghai Hongqiao Integrated Transport Hub in China

    Directory of Open Access Journals (Sweden)

    Peng Wei

    2016-01-01

    Full Text Available Tight schedules, multifunctional scopes, and colossal sizes usually characterize transportation megaprojects as challenging tasks for completion. In order to address these situations, a schedule risk management method was developed in this paper based on the structural equation model. In the proposed method, risk identification, evaluation and response were arranged as a sequence, and the expert elicitation technique was adopted in order to quantify the schedule risk status. To demonstrate the applicability of the proposed model, a megaproject case in China, the Shanghai Hongqiao Integrated Transport Hub (SHITH, was chosen. Information within the expanded risk register was collected including the probability and consequence of risk events, the complexity of risk responsible owners, the reaction time, and the time lasting for risk countermeasures. Final risk control results showed that the method could not only address the schedule risks correlations effectively, but also maintained the simplicity for construction management practices.

  1. Sexually Dimorphic Differentiation of a C. elegans Hub Neuron Is Cell Autonomously Controlled by a Conserved Transcription Factor.

    Science.gov (United States)

    Serrano-Saiz, Esther; Oren-Suissa, Meital; Bayer, Emily A; Hobert, Oliver

    2017-01-23

    Functional and anatomical sexual dimorphisms in the brain are either the result of cells that are generated only in one sex or a manifestation of sex-specific differentiation of neurons present in both sexes. The PHC neuron pair of the nematode C. elegans differentiates in a strikingly sex-specific manner. In hermaphrodites the PHC neurons display a canonical pattern of synaptic connectivity similar to that of other sensory neurons, but in males PHC differentiates into a densely connected hub sensory neuron/interneuron, integrating a large number of male-specific synaptic inputs and conveying them to both male-specific and sex-shared circuitry. We show that the differentiation into such a hub neuron involves the sex-specific scaling of several components of the synaptic vesicle machinery, including the vesicular glutamate transporter eat-4/VGLUT, induction of neuropeptide expression, changes in axonal projection morphology, and a switch in neuronal function. We demonstrate that these molecular and anatomical remodeling events are controlled cell autonomously by the phylogenetically conserved Doublesex homolog dmd-3, which is both required and sufficient for sex-specific PHC differentiation. Cellular specificity of dmd-3 action is ensured by its collaboration with non-sex-specific terminal selector-type transcription factors, whereas the sex specificity of dmd-3 action is ensured by the hermaphrodite-specific transcriptional master regulator of hermaphroditic cell identity tra-1, which represses the transcription of dmd-3 in hermaphrodite PHC. Taken together, our studies provide mechanistic insights into how neurons are specified in a sexually dimorphic manner.

  2. Graph theory reveals dysconnected hubs in 22q11DS and altered nodal efficiency in patients with hallucinations

    Directory of Open Access Journals (Sweden)

    Marie-Christine eOttet

    2013-09-01

    Full Text Available Schizophrenia is postulated to be the prototypical dysconnection disorder, in which hallucinations are the core symptom. Due to high heterogeneity in methodology across studies and the clinical phenotype, it remains unclear whether the structural brain dysconnection is global or focal and if clinical symptoms result from this dysconnection. In the present work, we attempt to clarify this issue by studying a population considered as a homogeneous genetic sub-type of schizophrenia, namely the 22q11.2 deletion syndrome (22q11.2DS. Cerebral MRIs were acquired for 46 patients and 48 age and gender matched controls (aged 6 to 26, respectively mean age = 15.20 ± 4.53 and 15.28 ± 4.35 years old. Using the Connectome mapper pipeline (connectomics.org that combines structural and diffusion MRI, we created a whole brain network for each individual. The graph theory was used to quantify the global and local properties in the brain network organization for each participant. A global degree loss of 6% was found in patients’ network along with an increased Characteristic Path Length. After identifying and comparing hubs, a significant loss of degree in patients’ hubs was found in 58% of them. Based on Allen’s brain network model for hallucinations, we explored the association between local efficiency and symptom severity. Negative correlations were found in the Broca’s area (p<0.004, the Wernicke area (p<0.023 and a positive correlation was found in the dorsolateral prefrontal cortex (DLPFC (p<0.014. In line with the dysconnection findings in schizophrenia, our results provide preliminary evidence for a targeted alteration in the brain network hubs’organisation in individuals with a genetic risk for schizophrenia. The study of specific disorganization in language, speech and thought regulation networks sharing similar network properties may help to understand their role in the hallucination mechanism.

  3. The (un)supervised NMF methods for discovering overlapping communities as well as hubs and outliers in networks

    Science.gov (United States)

    Wang, Xiao; Cao, Xiaochun; Jin, Di; Cao, Yixin; He, Dongxiao

    2016-03-01

    For its crucial importance in the study of large-scale networks, many researchers devote to the detection of communities in various networks. It is now widely agreed that the communities usually overlap with each other. In some communities, there exist members that play a special role as hubs (also known as leaders), whose importance merits special attention. Moreover, it is also observed that some members of the network do not belong to any communities in a convincing way, and hence recognized as outliers. Failure to detect and exclude outliers will distort, sometimes significantly, the outcome of the detected communities. In short, it is preferable for a community detection method to detect all three structures altogether. This becomes even more interesting and also more challenging when we take the unsupervised assumption, that is, we do not assume the prior knowledge of the number K of communities. Our approach here is to define a novel generative model and formalize the detection of overlapping communities as well as hubs and outliers as an optimization problem on it. When K is given, we propose a normalized symmetric nonnegative matrix factorization algorithm based on Kullback-Leibler (KL) divergence to learn the parameters of the model. Otherwise, by combining KL divergence and prior model on parameters, we introduce another parameter learning method based on Bayesian symmetric nonnegative matrix factorization to learn the parameters of the model, while determining K. Therefore, we present a community detection method arguably in the most general sense, which detects all three structures altogether without prior knowledge of the number of communities. Finally, we test the proposed method on various real-world networks. The experimental results, in contrast to several state-of-art algorithms, indicate its superior performance over other ones in terms of both clustering accuracy and community quality.

  4. Climate change and the water cycle: A new southwest regional climate hub curriculum unit for 6th-12th grade students

    Science.gov (United States)

    As climate change intensifies, increased temperatures and altered precipitation will make water, a limited resource in the arid southwestern United States, even scarcer in many locations. The USDA Southwest Regional Climate Hub (SWRCH) developed Climate Change and the Water Cycle, an engaging and sc...

  5. The Evolution of the MasAgro Hubs: Responsiveness and Serendipity as Drivers of Agricultural Innovation in a Dynamic and Heterogeneous Context

    Science.gov (United States)

    Camacho-Villa, Tania Carolina; Almekinders, Conny; Hellin, Jon; Martinez-Cruz, Tania Eulalia; Rendon-Medel, Roberto; Guevara-Hernández, Francisco; Beuchelt, Tina D.; Govaerts, Bram

    2016-01-01

    Purpose: Little is known about effective ways to operationalize agricultural innovation processes. We use the MasAgro program in Mexico (which aims to increase maize and wheat productivity, profitability and sustainability), and the experiences of middle level "hub managers", to understand how innovation processes occur in heterogeneous…

  6. Use of Hub Cutters and the Volume of Sharp Waste and Occurrence of Needle-Stick Injuries during 2011 Mass Immunization Campaigns against Yellow Fever in Ghana: A Cohort Study

    Directory of Open Access Journals (Sweden)

    E Agbenu

    2014-01-01

    Full Text Available Background: Current WHO best infection control practices for injections do not address the use of hub cutters due to insufficient evidence on safety and efficacy. Objective: To assess the impact of the use of hub cutters on 1 the frequency of needle-stick injuries (NSIs and other blood exposures among workers and 2 the volume of sharps waste in a mass vaccination campaign setting. Methods: During yellow fever vaccination in Ghana, we conducted a cohort study on the use of hub cutters. We compared two groups—one group using hub cutters and a control group—for the occurrences of NSIs and the volume of sharp waste produced. Results: In the control arm, vaccinators used 284 482 syringes in 825 vaccination sessions. In the group using hub cutter, vaccinators used 397 079 syringes in 1599 sessions. Among vaccinators, the rate of NSI was not significantly (p=0.14 different between the hub cutter users (0.15/10 000 syringes and the control group (0.04/10 000. Factors such as workload, lack of organization and pressure seemed to have influence the occurrence of NSIs. With all the limitations of the work, the volume of sharp waste per 10 000 syringes was 0.24 m3 in the hub cutter users and 0.41 m3 in the control group—a reduction of 41.2%. Vaccinators found hub cutters easy to use and safe. Use of hub cutter was not associated with increased duration of work. Conclusion: The use of hub cutters did not increase the risk of NSIs. More training is needed to facilitate its implementation in mass campaign setting.

  7. The effect of spherical hub-nose position on pressure drop in an oscillating water column system for wave energy conversion

    Energy Technology Data Exchange (ETDEWEB)

    Taha, Z.; Ahmad, N.; Ghazilla, R.A.R.; Yap, H.J.; Ya, T.Y.T.; Passarella, R.; Hasanuddin, I.; Yunus, M. [Malaya Univ. (Malaysia). Centre for Product Design and Manufacturing; Sugiyono [Malaya Univ., (Malaysia). Centre for Product Design and Manufacturing; Gadjah Mada Univ. (Indonesia). Dept. of Mechanical and Industrial Engineering

    2009-07-01

    The use of renewable energy sources as an alternative to conventional fuels was discussed with particular reference to ocean wave energy and its potential to contribute to the energy requirements of coastal nations. Ocean wave energy has been harnessed and converted into electricity using processes and technologies that are environmentally sound. The oscillating water column (OWC) system is considered to be among the most promising technology for harnessing wave energy. This paper presented the results of a study that investigated the pressure drop in an OWC system and the effect of spherical hub-nose position in an annular duct. Computational fluid dynamics (CFD) analysis was used under steady flow conditions for several hub-nose positions to determine the characteristic of pressure drop. The study showed that the hub-nose position influenced the pressure drop in the OWC system. The highest value of the pressure drop in this study occurred when the hub-nose was at the position of 0.0 m relative to the end of the converging cone. The pressure drop decreased when the hub-nose position moved away from the end of converging cone. The lowest value occurred at the position of -0.5 m. It was concluded that despite the numerically small change in pressure drop, this phenomenon should be considered in the design process of the OWC system because of the operational condition of the system at low-pressure pneumatic power. The pressure drop actually reduces the amount of energy that will be converted by the air turbine. 9 refs., 2 tabs., 6 figs.

  8. Investigation of load reduction for a variable speed, variable pitch, and variable coning wind turbine

    Energy Technology Data Exchange (ETDEWEB)

    Pierce, K. [Univ. of Utah, Salt Lake City, UT (United States)

    1997-12-31

    A two bladed, variable speed and variable pitch wind turbine was modeled using ADAMS{reg_sign} to evaluate load reduction abilities of a variable coning configuration as compared to a teetered rotor, and also to evaluate control methods. The basic dynamic behavior of the variable coning turbine was investigated and compared to the teetered rotor under constant wind conditions as well as turbulent wind conditions. Results indicate the variable coning rotor has larger flap oscillation amplitudes and much lower root flap bending moments than the teetered rotor. Three methods of control were evaluated for turbulent wind simulations. These were a standard IPD control method, a generalized predictive control method, and a bias estimate control method. Each control method was evaluated for both the variable coning configuration and the teetered configuration. The ability of the different control methods to maintain the rotor speed near the desired set point is evaluated from the RMS error of rotor speed. The activity of the control system is evaluated from cycles per second of the blade pitch angle. All three of the methods were found to produce similar results for the variable coning rotor and the teetered rotor, as well as similar results to each other.

  9. Benders decomposition algorithm for multi-distribution hub location problem%Benders分解算法在多分配枢纽选址问题的应用

    Institute of Scientific and Technical Information of China (English)

    王雷; 吴薇薇

    2012-01-01

    在通信和交通系统中,考虑到信息和商品OD流通提出了无容量限制多分配枢纽选址问题(UMAHLP).与在起点和终点建立点对点式直达方式运营不同,OD流经过枢纽节点中转的方式到达,通常称这种OD流以枢纽之间的连接作为中转的网络系统为枢纽辐射式航线网络.因此,求解该问题主要的工作是选择合理的枢纽,确定节点之间的连接方式,即每个OD对的产生的需求量,以达到网络的运营成本最小.文中主要提出一种改进的Benders分解算法求解无容量限制的多分配枢纽选址问题,在GMS软件平台上对问题进行求解,并且运用LINGO优化软件交互式求解方式中的分支定界算法得出问题精确解,说明Benders分解算法求解结果的合理性.%In telecommunication and transportation systems, the uncapacitated mulitiple allocation hub location problem ( UMAHLP) arises when the commodities or information between several origin-destination pairs circulates. Instead of establishing a direct node to node connection from an origin to its destination,the (lows are concentrated with others at facilities called hubs. These flows are transported on links established between hubs,being then splitted and delivered to its final destination. Systems with this sort of topology are named hub-and-spoke( HS) systems or hub-and-spoke networks. In this paper, an improved Benders decomposition algorithm is no more limited capacity allocation hub location problem,in the CMS software platform for problem solving, and interactive use of LINGO optimization software solution in the way the issue of branch and bound algorithm derived exact solution,indicating the Benders decomposition algorithm results is reasonable.

  10. Gas supermarket: Dawn pipeline junction rises as a trading hub on a continental scale in southwestern Ontario

    Energy Technology Data Exchange (ETDEWEB)

    Faulkner, P.

    1999-11-01

    Dawn, Ontario, a small farming community near Sarnia's famed chemical valley is the site of the Union Gas Dawn Operations Centre. The region's capacity to store gas in geological formations beneath fertile fertile farm land will be used more and more with the completion of pipelines that will transmit more Alberta natural gas to markets in the eastern United States through Ontario. Its central location, a growing Ontario-Quebec market and prospects of more incoming gas appear to have conferred upon Dawn the status of a premier trading hub in Canada and maybe in North America, spurred on by regulatory regimes on both sides of the border that favour free trade in natural gas and the growing demand in the previously under-served northeastern United States materialize. The Dawn center trades gas for more than 100 energy companies, several of them electricity providers, that have been recently allowed to step into the market territory formerly occupied by Ontario Hydro. Natural gas is replacing coal burning power stations and to some extent, nuclear power in Ontario; the trend is also strong in the New England states, hence future demand for natural gas is likely to increase. It is this reasoning that underlies the construction of new pipelines, such as the Alliance Project, which will move gas from Alberta into the United States, back to Canada at Dawn, then back again into New York. If all goes according to plan, another new route called Millennium will run east from Dawn than travel under Lake Erie to join the Columbia Gas System that feeds New York City. Another line -- Vector -- that will geographically diversify west-east trading capabilities, also received FERC and NEB approval early in 1999. Yet another line by TriState, initially denied a US permit, recently received preliminary FERC approval, conditional upon approval by NEB. It is easy to see that with the spread of deregulation and competition, Dawn's role as a trading hub and as a storage

  11. The role of conceptual knowledge in understanding synaesthesia: Evaluating contemporary findings from a “hub-and-spokes” perspective

    Science.gov (United States)

    Chiou, Rocco

    2014-01-01

    maintained within a supramodal “hub,” while the subjective (bodily) experience of its resultant concurrent (e.g., a color) may then require activation of “spokes” in the perception-related cortices. This hypothesized “hub-and-spoke” structure would engage a distributed network of cortical regions and may account for the full breadth of this intriguing phenomenon. PMID:24653707

  12. On the Improvement of Numerical Weather Prediction by Assimilation of Hub Height Wind Information in Convection-Resulted Models

    Science.gov (United States)

    Declair, Stefan; Stephan, Klaus; Potthast, Roland

    2015-04-01

    Determining the amount of weather dependent renewable energy is a demanding task for transmission system operators (TSOs). In the project EWeLiNE funded by the German government, the German Weather Service and the Fraunhofer Institute on Wind Energy and Energy System Technology strongly support the TSOs by developing innovative weather- and power forecasting models and tools for grid integration of weather dependent renewable energy. The key in the energy prediction process chain is the numerical weather prediction (NWP) system. With focus on wind energy, we face the model errors in the planetary boundary layer, which is characterized by strong spatial and temporal fluctuations in wind speed, to improve the basis of the weather dependent renewable energy prediction. Model data can be corrected by postprocessing techniques such as model output statistics and calibration using historical observational data. On the other hand, latest observations can be used in a preprocessing technique called data assimilation (DA). In DA, the model output from a previous time step is combined such with observational data, that the new model data for model integration initialization (analysis) fits best to the latest model data and the observational data as well. Therefore, model errors can be already reduced before the model integration. In this contribution, the results of an impact study are presented. A so-called OSSE (Observation Simulation System Experiment) is performed using the convective-resoluted COSMO-DE model of the German Weather Service and a 4D-DA technique, a Newtonian relaxation method also called nudging. Starting from a nature run (treated as the truth), conventional observations and artificial wind observations at hub height are generated. In a control run, the basic model setup of the nature run is slightly perturbed to drag the model away from the beforehand generated truth and a free forecast is computed based on the analysis using only conventional

  13. A DNA-Centric Protein Interaction Map of Ultraconserved Elements Reveals Contribution of Transcription Factor Binding Hubs to Conservation

    Directory of Open Access Journals (Sweden)

    Tar Viturawong

    2013-10-01

    Full Text Available Ultraconserved elements (UCEs have been the subject of great interest because of their extreme sequence identity and their seemingly cryptic and largely uncharacterized functions. Although in vivo studies of UCE sequences have demonstrated regulatory activity, protein interactors at UCEs have not been systematically identified. Here, we combined high-throughput affinity purification, high-resolution mass spectrometry, and SILAC quantification to map intrinsic protein interactions for 193 UCE sequences. The interactome contains over 400 proteins, including transcription factors with known developmental roles. We demonstrate based on our data that UCEs consist of strongly conserved overlapping binding sites. We also generated a fine-resolution interactome of a UCE, confirming the hub-like nature of the element. The intrinsic interactions mapped here are reflected in open chromatin, as indicated by comparison with existing ChIP data. Our study argues for a strong contribution of protein-DNA interactions to UCE conservation and provides a basis for further functional characterization of UCEs.

  14. ANRIL lncRNA triggers efficient therapeutic efficacy by reprogramming the aberrant INK4-hub in melanoma.

    Science.gov (United States)

    Xu, Shiqiong; Wang, Huixue; Pan, Hui; Shi, Yingyun; Li, Tianyuan; Ge, Shengfang; Jia, Renbing; Zhang, He; Fan, Xianqun

    2016-10-10

    Melanoma is an extremely aggressive disease with rapid progression, high metastatic potential and recurrence. Simultaneous correction of multiple tumor-specific gene abnormalities has become an attractive approach for developing therapeutics to treat melanoma. To potentiate anti-melanoma activity, we tested a "domino effect-like" therapeutic approach by uniquely targeting one defect and automatically triggering the endogenous corrections of other defects. Using this strategy, in a suspicious INK4b-ARF-INK4a gene cluster at chromosome 9p21, aberrant INK4a and INK4b defects were simultaneously endogenously auto-corrected after targeting the suppression of abnormal ANRIL lncRNA. In cell culture, this treatment significantly reduced the tumor metastatic capacity and tumor formation compared with absence of treatment. In animals harboring tumor xenografts, this therapeutic approach significantly inhibited tumor growth and reduced the tumor weight. Our results reveal a novel therapeutic strategy that significantly potentiates anti-melanoma efficiency by reprogramming the aberrant INK4-hub. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  15. Structural and Dynamic Characterization of the Molecular Hub Early Region 1A (E1A) from Human Adenovirus.

    Science.gov (United States)

    Hošek, Tomáš; Calçada, Eduardo O; Nogueira, Marcela Oliveira; Salvi, Michele; Pagani, Talita Duarte; Felli, Isabella C; Pierattelli, Roberta

    2016-09-05

    The small-DNA human adenovirus encodes one of the most versatile molecular hubs, the E1A protein. This protein is essential for productive viral infection in human cells and a vast amount of biologically relevant data are available on its interactions with host proteins. Up to now, however, no high-resolution structural and dynamic information on E1A is available despite its important biological role. Among the different spliced variants of E1A, two are expressed at high level in the early stage of infection. These are 243 and 289 residues isoforms. Herein, we present their NMR characterization, showing that they are both highly disordered, but also demonstrate a certain heterogeneous behavior in terms of structural and dynamic properties. Furthermore, we present the characterization of the isolated domain of the longer variant, known as CR3. This study opens the way to understanding at the molecular level how E1A functions. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Cross-frequency power correlations reveal the right superior temporal gyrus as a hub region during working memory maintenance.

    Science.gov (United States)

    Park, Hyojin; Kang, Eunjoo; Kang, Hyejin; Kim, June Sic; Jensen, Ole; Chung, Chun Kee; Lee, Dong Soo

    2011-01-01

    In the present study, we characterized within- and cross-frequency power correlations from magnetoencephalography (MEG) data in order to understand how different brain regions cooperate as a network to maintain working memory representations with several features. The working memory items were composed of spatially arranged dots supposedly requiring both the dorsal and the ventral stream to be engaged during maintenance. Using a beamforming technique, we localized memory-dependent sources in the alpha, beta, and gamma bands. After the single-trial power values were extracted from these frequency bands with respect to each source, we calculated the correlations within- and cross-frequency bands. The following general picture emerged: gamma power in right superior temporal gyrus (STG) during working memory maintenance was correlated with numerous other sources in the alpha band in prefrontal, parietal, and posterior regions. In addition, the power correlations within the alpha band showed correlations across posterior-parietal-frontal regions. From these findings, we suggest that the STG dominated by gamma activity serves as a hub region for the network nodes responsible for the retention of the stimulus used in this study, which is likely to depend on both the "where-" and the "what-" visual system simultaneously. The present study demonstrates how oscillatory dynamics reflecting the interaction between cortical areas can be investigated by means of cross-frequency power correlations in source space. This methodological framework could be of general utility when studying functional network properties of the working brain.

  17. Gene transcription profiles associated with inter-modular hubs and connection distance in human functional magnetic resonance imaging networks

    Science.gov (United States)

    Vértes, Petra E.; Rittman, Timothy; Whitaker, Kirstie J.; Romero-Garcia, Rafael; Váša, František; Wagstyl, Konrad; Fonagy, Peter; Dolan, Raymond J.; Jones, Peter B.; Goodyer, Ian M.

    2016-01-01

    Human functional magnetic resonance imaging (fMRI) brain networks have a complex topology comprising integrative components, e.g. long-distance inter-modular edges, that are theoretically associated with higher biological cost. Here, we estimated intra-modular degree, inter-modular degree and connection distance for each of 285 cortical nodes in multi-echo fMRI data from 38 healthy adults. We used the multivariate technique of partial least squares (PLS) to reduce the dimensionality of the relationships between these three nodal network parameters and prior microarray data on regional expression of 20 737 genes. The first PLS component defined a transcriptional profile associated with high intra-modular degree and short connection distance, whereas the second PLS component was associated with high inter-modular degree and long connection distance. Nodes in superior and lateral cortex with high inter-modular degree and long connection distance had local transcriptional profiles enriched for oxidative metabolism and mitochondria, and for genes specific to supragranular layers of human cortex. In contrast, primary and secondary sensory cortical nodes in posterior cortex with high intra-modular degree and short connection distance had transcriptional profiles enriched for RNA translation and nuclear components. We conclude that, as predicted, topologically integrative hubs, mediating long-distance connections between modules, are more costly in terms of mitochondrial glucose metabolism. This article is part of the themed issue ‘Interpreting BOLD: a dialogue between cognitive and cellular neuroscience’. PMID:27574314

  18. New models to support the professional education of health visitors: A qualitative study of the role of space and place in creating 'community of learning hubs'.

    Science.gov (United States)

    Donetto, Sara; Malone, Mary; Sayer, Lynn; Robert, Glenn

    2017-07-01

    In response to a policy-driven workforce expansion in England new models of preparing health visitors for practice have been implemented. 'Community of Learning hubs' (COLHs) are one such model, involving different possible approaches to student support in clinical practice placements (for example, 'long arm mentoring' or 'action learning set' sessions). Such models present opportunities for studying the possible effects of spatiality on the learning experiences of students and newly qualified health visitors, and on team relationships more broadly. To explore a 'community of learning hub' model in health visitor education and reflect on the role of space and place in the learning experience and professional identity development of student health visitors. Qualitative research conducted during first year of implementation. Three 'community of learning hub' projects based in two NHS community Trusts in London during the period 2013-2015. Managers and leads (n=7), practice teachers and mentors (n=6) and newly qualified and student health visitors (n=16). Semi-structured, audio-recorded interviews analysed thematically. Participants had differing views as to what constituted a 'hub' in their projects. Two themes emerged around the spaces that shape the learning experience of student and newly qualified health visitors. Firstly, a generalised need for a 'quiet place' which allows pause for reflection but also for sharing experiences and relieving common anxieties. Secondly, the role of physical arrangements in open-plan spaces to promote access to support from more experienced practitioners. Attention to spatiality can shed light on important aspects of teaching and learning practices, and on the professional identities these practices shape and support. New configurations of time and space as part of educational initiatives can surface new insights into existing practices and learning models. Copyright © 2017. Published by Elsevier Ltd.

  19. Dynamic Prediction Method of Transfer OD Matrix for Urban Transit Hub%城市公交枢纽换乘客流OD动态预测方法

    Institute of Scientific and Technical Information of China (English)

    胡华; 刘志钢; 朱海燕

    2013-01-01

    A transfer OD matrix is the basic data for coordination dispatching among transit lines in a transit hub under Advance Public Transportation System (APTS).A BP artificial neural network (ANN) model is applied to track the weights of OD pairs within a transit hub through using the data of boarding and alighting transfer passengers at each transit line.The key issues associated with the estimation process are deeply studied,including the design of ANN,the learning and stopping rules,and the calibration of model parameters through computational experiment.The results of the example from a transit hub reveal that the proposed model provides an economic and effective method for dynamic prediction of transfer OD matrix for a transit hub.%换乘枢纽衔接公交线路的换乘客流OD是APTS下实施公交多线路动态协调调度的基础数据.以公交线路上下车乘客数的自动获取为前提,建立换乘OD推算优化模型,并设计了BP神经网络求解算法,应用数值试验对神经网络中的核心参数进行了标定.算例表明:BP神经网络为动态更新公交枢纽换乘客流OD提供了一种经济、有效的方法.

  20. New hierarchical classification of food items for the assessment of exposure to packaging migrants: use of hub codes for different food groups.

    Science.gov (United States)

    Northing, P; Oldring, P K T; Castle, L; Mason, P A S S

    2009-04-01

    This paper describes development work undertaken to expand the capabilities of an existing two-dimensional probabilistic modelling approach for assessing dietary exposure to chemicals migrating out of food contact materials. A new three-level hub-coding system has been devised for coding different food groups with regards to their consumption by individuals. The hub codes can be used at three different levels representing a high, medium and low level of aggregation of individual food items. The hub codes were developed because they have a greater relevance to packaging migration than coding used (largely and historically) for nutritional purposes. Also, the hub codes will assist pan-europeanization of the exposure model in the future, when up to 27 or more different food coding systems from 27 European Union Member States will have to be assimilated into the modelling approach. The applicability of the model with the new coding system has been tested by incorporating newly released 2001 UK consumption data. The example used was exposure to a hypothetical migrant from coated metal packaging for foodstuffs. When working at the three hierarchical levels, it was found that the tiered approach gave conservative estimates at the cruder level of refinement and a more realistic assessment was obtained as the refinement progressed. The work overall revealed that changes in eating habits over time had a relatively small impact on estimates of exposure. More important impacts are changes over time in packaging usage, packaging composition and migration levels. For countries like the UK, which has sophisticated food consumption data, it is uncertainties in these other areas that need to be addressed by new data collection.

  1. Indoor air quality at nine large-hub airports with and without designated smoking areas--United States, October-November 2012.

    Science.gov (United States)

    2012-11-23

    Secondhand smoke (SHS) exposure causes death and disease among nonsmoking adults and children. Adopting policies that completely prohibit smoking in all indoor areas is the only effective way to eliminate involuntary SHS exposure. Among the 29 large-hub U.S. airports, five currently allow smoking in specifically designated indoor areas accessible to the general public. In 2011, these five airports had a combined passenger boarding of approximately 110 million. To assess indoor air quality at the five large-hub U.S. airports with designated indoor smoking areas and compare it with the indoor air quality at four large-hub U.S. airports that prohibit smoking in all indoor areas, CDC measured the levels of respirable suspended particulates (RSPs), a marker for SHS. The results of this assessment determined that the average level of RSPs in the smoking-permitted areas of these five airports was 16 times the average level in nonsmoking areas (boarding gate seating sections) and 23 times the average level of RSPs in the smoke-free airports. The average RSP level in areas adjacent to the smoking-permitted areas was four times the average level in nonsmoking areas of the five airports with designated smoking areas and five times the average level in smoke-free airports. Smoke-free policies at the state, local, or airport authority levels can eliminate involuntary exposure to SHS inside airports and protect employees and travelers of all ages from SHS.

  2. Mapping the Multiple Graded Contributions of the Anterior Temporal Lobe Representational Hub to Abstract and Social Concepts: Evidence from Distortion-corrected fMRI.

    Science.gov (United States)

    Binney, Richard J; Hoffman, Paul; Lambon Ralph, Matthew A

    2016-09-06

    A growing body of recent convergent evidence indicates that the anterior temporal lobe (ATL) has connectivity-derived graded differences in semantic function: the ventrolateral region appears to be the transmodal, omni-category center-point of the hub whilst secondary contributions come from the peripheries of the hub in a manner that reflects their differential connectivity to different input/output modalities. One of the key challenges for this neurocognitive theory is how different types of concept, especially those with less reliance upon external sensory experience (such as abstract and social concepts), are coded across the graded ATL hub. We were able to answer this key question by using distortion-corrected fMRI to detect functional activations across the entire ATL region and thus to map the neural basis of social and psycholinguistically-matched abstract concepts. Both types of concept engaged a core left-hemisphere semantic network, including the ventrolateral ATL, prefrontal regions and posterior MTG. Additionally, we replicated previous findings of weaker differential activation of the superior and polar ATL for the processing of social stimuli, in addition to the stronger, omni-category activation observed in the vATL. These results are compatible with the view of the ATL as a graded transmodal substrate for the representation of coherent concepts.

  3. Mapping the Multiple Graded Contributions of the Anterior Temporal Lobe Representational Hub to Abstract and Social Concepts: Evidence from Distortion-corrected fMRI

    Science.gov (United States)

    Binney, Richard J.; Hoffman, Paul; Lambon Ralph, Matthew A.

    2016-01-01

    A growing body of recent convergent evidence indicates that the anterior temporal lobe (ATL) has connectivity-derived graded differences in semantic function: the ventrolateral region appears to be the transmodal, omni-category center-point of the hub whilst secondary contributions come from the peripheries of the hub in a manner that reflects their differential connectivity to different input/output modalities. One of the key challenges for this neurocognitive theory is how different types of concept, especially those with less reliance upon external sensory experience (such as abstract and social concepts), are coded across the graded ATL hub. We were able to answer this key question by using distortion-corrected fMRI to detect functional activations across the entire ATL region and thus to map the neural basis of social and psycholinguistically-matched abstract concepts. Both types of concept engaged a core left-hemisphere semantic network, including the ventrolateral ATL, prefrontal regions and posterior MTG. Additionally, we replicated previous findings of weaker differential activation of the superior and polar ATL for the processing of social stimuli, in addition to the stronger, omni-category activation observed in the vATL. These results are compatible with the view of the ATL as a graded transmodal substrate for the representation of coherent concepts. PMID:27600844

  4. Application of the wheel hub bearing in agricultural machinery%论轮毂轴承在农机机械中的应用

    Institute of Scientific and Technical Information of China (English)

    孟晓慧; 李华庆

    2013-01-01

      随着农业现代化的发展,农机使用日渐广泛,作为农机重要载荷部件的轮毂轴承也在向可靠性、集成化、小型化发展。文章介绍了农机轮毂轴承的发展、技术趋势并对农机轮毂轴承的故障原因进行了分析提出了维护保养措施。%With the development of agricultural modernization, agricultural machinery are widely used , wheel hub bearing is a important load part of agricultural machinery which becomes reliable and integrated and small.The article in-troduces the development and technical trend of wheel hub bearing of agricultural machinery and analyzes failure causes of wheel hub bearing of agricultural machinery and presents measures of maintenance.

  5. Why do hubs in the yeast protein interaction network tend to be essential: reexamining the connection between the network topology and essentiality.

    Directory of Open Access Journals (Sweden)

    Elena Zotenko

    Full Text Available The centrality-lethality rule, which notes that high-degree nodes in a protein interaction network tend to correspond to proteins that are essential, suggests that the topological prominence of a protein in a protein interaction network may be a good predictor of its biological importance. Even though the correlation between degree and essentiality was confirmed by many independent studies, the reason for this correlation remains illusive. Several hypotheses about putative connections between essentiality of hubs and the topology of protein-protein interaction networks have been proposed, but as we demonstrate, these explanations are not supported by the properties of protein interaction networks. To identify the main topological determinant of essentiality and to provide a biological explanation for the connection between the network topology and essentiality, we performed a rigorous analysis of six variants of the genomewide protein interaction network for Saccharomyces cerevisiae obtained using different techniques. We demonstrated that the majority of hubs are essential due to their involvement in Essential Complex Biological Modules, a group of densely connected proteins with shared biological function that are enriched in essential proteins. Moreover, we rejected two previously proposed explanations for the centrality-lethality rule, one relating the essentiality of hubs to their role in the overall network connectivity and another relying on the recently published essential protein interactions model.

  6. Laser Hardening of 45CrNi Steel Outer Hub%45 CrNi钢外毂的激光淬火

    Institute of Scientific and Technical Information of China (English)

    张连凤; 武明亮; 徐庆元

    2014-01-01

    研究了45CrNi钢外毂激光淬火后的组织和性能。结果表明,激光平面扫描速度为270 mm/min,激光功率为2 kW时,淬硬层深度为1.2 mm;内孔扫描速度为350 mm/min,激光功率1.2 kW时,淬硬层深度为0.8 mm,表面硬度达到60 HRC,符合要求。%The microstructure and properties of 45CrNi steel outer hub after laser hardening were investigated .The results show that the plane of the outer hub may be hardened to a depth of 1 .2 mm when the laser scanning speed is 270 mm/min and the laser power is 2 kW,and that the inner hole of the outer hub may be hardened to a depth of 0.8 mm when the laser scanning speed is 350 mm/min and the laser power is 1.2 kW.Furthermore, the surface hardness is as high as 60 HRC, conforming with hardness requirements .

  7. Discussion on water diversion hub layout in Budaer Hydropower Station%布达尔水电站工程引水枢纽布置探讨

    Institute of Scientific and Technical Information of China (English)

    吴建良

    2015-01-01

    Design process of Budaer Hydropower Station is not limited to a fixed form or fixed experience aiming at characteristics of rivers in Xinjiang mountainous area.Concrete conditions of projects are fully considered,design concepts are updated,and design ideas are expanded.Advantages and disadvantages of river sluice water diversion hub and river weir water diversion hub are concretely analyzed and compared according to project design examples.Necessity and rationality of the water diversion hub layout mode are correspondingly studied and discussed.%在布达尔水电站设计过程中,针对新疆山区河流的特点,不限于某一种固定形式,不拘泥于固定经验,充分考虑到工程项目的具体情况,更新设计观念,拓展设计思路,依据工程设计实例,对拦河闸式引水枢纽和拦河堰式引水枢纽的优缺点作了具体的分析比较,并对该引水枢纽布置方式的必要性及合理性进行了相应的研究和探讨。

  8. Global Dynamics and International Cooperation Needs of RT Development and Utilization for the Establishment of the Northeast Asia RT Hub in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Y. K.; Oh, G. B.; Yun, S. W.; Yang, M. H.; Ryu, J. S.; Choi, S. J.; Choi, S. G

    2005-11-15

    In an effort to achieve the objectives, the following scopes were categorized for in-depth study. First, analysis framework was developed for RT capacity development and international technology cooperation strategy. RT survey checklist and international technology cooperation was analyzed with interviewing and reports of domestic participants recently. Second, RT strategic environment was analyze for East-Asia hub competition/cooperation and developing nations using analysis framework. Korean RT was analyzed using SWOT analysis for establishment of RT hub in Korea. Third, East-Asian nations were classified analyzed by RT categories in standpoint of our country. Technology status and future cooperation plan were discussed about RT application for bio-medicine. Products/technology seminar related to an export was hold about support plan of admission/sales for functional food HemoHIM. This study can be utilized in the establishment of RT hub and development strategy. And it can be also utilized in promotion devising of domestic RT and planning setup for obtaing the international competitive power.

  9. Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders

    Science.gov (United States)

    Alfieri, Annalisa; Sorokina, Oksana; Adrait, Annie; Angelini, Costanza; Russo, Isabella; Morellato, Alessandro; Matteoli, Michela; Menna, Elisabetta; Boeri Erba, Elisabetta; McLean, Colin; Armstrong, J. Douglas; Ala, Ugo; Buxbaum, Joseph D.; Brusco, Alfredo; Couté, Yohann; De Rubeis, Silvia; Turco, Emilia; Defilippi, Paola

    2017-01-01

    Altered synaptic function has been associated with neurological and psychiatric conditions including intellectual disability, schizophrenia and autism spectrum disorder (ASD). Amongst the recently discovered synaptic proteins is p140Cap, an adaptor that localizes at dendritic spines and regulates their maturation and physiology. We recently showed that p140Cap knockout mice have cognitive deficits, impaired long-term potentiation (LTP) and long-term depression (LTD), and immature, filopodia-like dendritic spines. Only a few p140Cap interacting proteins have been identified in the brain and the molecular complexes and pathways underlying p140Cap synaptic function are largely unknown. Here, we isolated and characterized the p140Cap synaptic interactome by co-immunoprecipitation from crude mouse synaptosomes, followed by mass spectrometry-based proteomics. We identified 351 p140Cap interactors and found that they cluster to sub complexes mostly located in the postsynaptic density (PSD). p140Cap interactors converge on key synaptic processes, including transmission across chemical synapses, actin cytoskeleton remodeling and cell-cell junction organization. Gene co-expression data further support convergent functions: the p140Cap interactors are tightly co-expressed with each other and with p140Cap. Importantly, the p140Cap interactome and its co-expression network show strong enrichment in genes associated with schizophrenia, autism, bipolar disorder, intellectual disability and epilepsy, supporting synaptic dysfunction as a shared biological feature in brain diseases. Overall, our data provide novel insights into the molecular organization of the synapse and indicate that p140Cap acts as a hub for postsynaptic complexes relevant to psychiatric and neurological disorders. PMID:28713243

  10. Temporal network based analysis of cell specific vein graft transcriptome defines key pathways and hub genes in implantation injury.

    Directory of Open Access Journals (Sweden)

    Manoj Bhasin

    Full Text Available Vein graft failure occurs between 1 and 6 months after implantation due to obstructive intimal hyperplasia, related in part to implantation injury. The cell-specific and temporal response of the transcriptome to vein graft implantation injury was determined by transcriptional profiling of laser capture microdissected endothelial cells (EC and medial smooth muscle cells (SMC from canine vein grafts, 2 hours (H to 30 days (D following surgery. Our results demonstrate a robust genomic response beginning at 2 H, peaking at 12-24 H, declining by 7 D, and resolving by 30 D. Gene ontology and pathway analyses of differentially expressed genes indicated that implantation injury affects inflammatory and immune responses, apoptosis, mitosis, and extracellular matrix reorganization in both cell types. Through backpropagation an integrated network was built, starting with genes differentially expressed at 30 D, followed by adding upstream interactive genes from each prior time-point. This identified significant enrichment of IL-6, IL-8, NF-κB, dendritic cell maturation, glucocorticoid receptor, and Triggering Receptor Expressed on Myeloid Cells (TREM-1 signaling, as well as PPARα activation pathways in graft EC and SMC. Interactive network-based analyses identified IL-6, IL-8, IL-1α, and Insulin Receptor (INSR as focus hub genes within these pathways. Real-time PCR was used for the validation of two of these genes: IL-6 and IL-8, in addition to Collagen 11A1 (COL11A1, a cornerstone of the backpropagation. In conclusion, these results establish causality relationships clarifying the pathogenesis of vein graft implantation injury, and identifying novel targets for its prevention.

  11. Innovative Technological Approach to Ebola Virus Disease Outbreak Response in Nigeria Using the Open Data Kit and Form Hub Technology.

    Science.gov (United States)

    Tom-Aba, Daniel; Olaleye, Adeniyi; Olayinka, Adebola Tolulope; Nguku, Patrick; Waziri, Ndadilnasiya; Adewuyi, Peter; Adeoye, Olawunmi; Oladele, Saliu; Adeseye, Aderonke; Oguntimehin, Olukayode; Shuaib, Faisal

    2015-01-01

    The recent outbreak of Ebola Virus Disease (EVD) in West Africa has ravaged many lives. Effective containment of this outbreak relies on prompt and effective coordination and communication across various interventions; early detection and response being critical to successful control. The use of information and communications technology (ICT) in active surveillance has proved to be effective but its use in Ebola outbreak response has been limited. Due to the need for timeliness in reporting and communication for early discovery of new EVD cases and promptness in response; it became imperative to empower the response team members with technologies and solutions which would enable smooth and rapid data flow. The Open Data Kit and Form Hub technology were used in combination with the Dashboard technology and ArcGIS mapping for follow up of contacts, identification of cases, case investigation and management and also for strategic planning during the response. A remarkable improvement was recorded in the reporting of daily follow-up of contacts after the deployment of the integrated real time technology. The turnaround time between identification of symptomatic contacts and evacuation to the isolation facility and also for receipt of laboratory results was reduced and informed decisions could be taken by all concerned. Accountability in contact tracing was ensured by the use of a GPS enabled device. The use of innovative technologies in the response of the EVD outbreak in Nigeria contributed significantly to the prompt control of the outbreak and containment of the disease by providing a valuable platform for early warning and guiding early actions.

  12. Innovative Technological Approach to Ebola Virus Disease Outbreak Response in Nigeria Using the Open Data Kit and Form Hub Technology.

    Directory of Open Access Journals (Sweden)

    Daniel Tom-Aba

    Full Text Available The recent outbreak of Ebola Virus Disease (EVD in West Africa has ravaged many lives. Effective containment of this outbreak relies on prompt and effective coordination and communication across various interventions; early detection and response being critical to successful control. The use of information and communications technology (ICT in active surveillance has proved to be effective but its use in Ebola outbreak response has been limited. Due to the need for timeliness in reporting and communication for early discovery of new EVD cases and promptness in response; it became imperative to empower the response team members with technologies and solutions which would enable smooth and rapid data flow. The Open Data Kit and Form Hub technology were used in combination with the Dashboard technology and ArcGIS mapping for follow up of contacts, identification of cases, case investigation and management and also for strategic planning during the response. A remarkable improvement was recorded in the reporting of daily follow-up of contacts after the deployment of the integrated real time technology. The turnaround time between identification of symptomatic contacts and evacuation to the isolation facility and also for receipt of laboratory results was reduced and informed decisions could be taken by all concerned. Accountability in contact tracing was ensured by the use of a GPS enabled device. The use of innovative technologies in the response of the EVD outbreak in Nigeria contributed significantly to the prompt control of the outbreak and containment of the disease by providing a valuable platform for early warning and guiding early actions.

  13. A transcriptome-proteome integrated network identifies endoplasmic reticulum thiol oxidoreductase (ERp57) as a hub that mediates bone metastasis.

    Science.gov (United States)

    Santana-Codina, Naiara; Carretero, Rafael; Sanz-Pamplona, Rebeca; Cabrera, Teresa; Guney, Emre; Oliva, Baldo; Clezardin, Philippe; Olarte, Omar E; Loza-Alvarez, Pablo; Méndez-Lucas, Andrés; Perales, Jose Carlos; Sierra, Angels

    2013-08-01

    Bone metastasis is the most common distant relapse in breast cancer. The identification of key proteins involved in the osteotropic phenotype would represent a major step toward the development of new prognostic markers and therapeutic improvements. The aim of this study was to characterize functional phenotypes that favor bone metastasis in human breast cancer. We used the human breast cancer cell line MDA-MB-231 and its osteotropic BO2 subclone to identify crucial proteins in bone metastatic growth. We identified 31 proteins, 15 underexpressed and 16 overexpressed, in BO2 cells compared with parental cells. We employed a network-modeling approach in which these 31 candidate proteins were prioritized with respect to their potential in metastasis formation, based on the topology of the protein-protein interaction network and differential expression. The protein-protein interaction network provided a framework to study the functional relationships between biological molecules by attributing functions to genes whose functions had not been characterized. The combination of expression profiles and protein interactions revealed an endoplasmic reticulum-thiol oxidoreductase, ERp57, functioning as a hub that retained four down-regulated nodes involved in antigen presentation associated with the human major histocompatibility complex class I molecules, including HLA-A, HLA-B, HLA-E, and HLA-F. Further analysis of the interaction network revealed an inverse correlation between ERp57 and vimentin, which influences cytoskeleton reorganization. Moreover, knockdown of ERp57 in BO2 cells confirmed its bone organ-specific prometastatic role. Altogether, ERp57 appears as a multifunctional chaperone that can regulate diverse biological processes to maintain the homeostasis of breast cancer cells and promote the development of bone metastasis.

  14. The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt.

    Science.gov (United States)

    Kay, Sophie K; Harrington, Heather A; Shepherd, Sarah; Brennan, Keith; Dale, Trevor; Osborne, James M; Gavaghan, David J; Byrne, Helen M

    2017-02-28

    The Notch pathway plays a vital role in determining whether cells in the intestinal epithelium adopt a secretory or an absorptive phenotype. Cell fate specification is coordinated via Notch's interaction with the canonical Wnt pathway. Here, we propose a new mathematical model of the Notch and Wnt pathways, in which the Hes1 promoter acts as a hub for pathway crosstalk. Computational simulations of the model can assist in understanding how healthy intestinal tissue is maintained, and predict the likely consequences of biochemical knockouts upon cell fate selection processes. Chemical reaction network theory (CRNT) is a powerful, generalised framework which assesses the capacity of our model for monostability or multistability, by analysing properties of the underlying network structure without recourse to specific parameter values or functional forms for reaction rates. CRNT highlights the role of β-catenin in stabilising the Notch pathway and damping oscillations, demonstrating that Wnt-mediated actions on the Hes1 promoter can induce dynamic transitions in the Notch system, from multistability to monostability. Time-dependent model simulations of cell pairs reveal the stabilising influence of Wnt upon the Notch pathway, in which β-catenin- and Dsh-mediated action on the Hes1 promoter are key in shaping the subcellular dynamics. Where Notch-mediated transcription of Hes1 dominates, there is Notch oscillation and maintenance of fate flexibility; Wnt-mediated transcription of Hes1 favours bistability akin to cell fate selection. Cells could therefore regulate the proportion of Wnt- and Notch-mediated control of the Hes1 promoter to coordinate the timing of cell fate selection as they migrate through the intestinal epithelium and are subject to reduced Wnt stimuli. Furthermore, mutant cells characterised by hyperstimulation of the Wnt pathway may, through coupling with Notch, invert cell fate in neighbouring healthy cells, enabling an aberrant cell to maintain its

  15. Universities as Development Hubs

    DEFF Research Database (Denmark)

    Hansen, Jens Aage; Lindegaard, Klaus; Lehmann, Martin

    2005-01-01

    international aid programmes to tertiary education, including research and innovation in an interplay with other research institutions and business. In the absence of such support the so-called digital divide between industrial and developing and transition countries will widen, and brain-drain and poverty......) and Europe (Denmark) have collaborated with graduate students and faculty. Initially some programmes emphasised research and others higher education, but eventually a blend of research and higher education appeared to be more productive. Links to external partners in public and private business have been...... been promising in terms of concrete results within each type of activity and together they provide vital steps in capacity-building in tertiary education to the benefit of development and environment. Some of the results and their implications are presented in this chapter and more are documented...

  16. Indico: CERN Collaboration Hub

    CERN Document Server

    CERN. Geneva

    2012-01-01

    Indico development is also moving towards a broader collaboration where other institutes, hosting their own Indico instance, can contribute to the project in order make it a better and more complete tool.

  17. Financial Hub? Be Patient!

    Institute of Scientific and Technical Information of China (English)

    Guo Yan

    2009-01-01

    @@ In 2009,the central government confirmed the strategic significance of Shanghai as an international financial center.Until now.Shanghai's financial cluster has attracted more and more foreign banks to establish roots jn Shanghai,which has contributed to their rapid development in recent years.The announcement undoubtedly made foreign banks confident of great development potential in the future.But what opportunities could they catch?Also,will this weaken the position of Hong Kong as an International financial center?China's Foreign Trade invited Ms.Katherine Tsang,chief executive officer of Standard Chartered China to share with us her point of view.

  18. Universities as Development Hubs

    DEFF Research Database (Denmark)

    Hansen, Jens Aage; Lindegaard, Klaus; Lehmann, Martin

    2005-01-01

    by references. Strengthening of tertiary education is assumed to be a prerequisite for economic and democratic development in all countries, be they industrialised, in transition or developing. However, particularly in transition and developing countries there is a need for special support, e.g. through...... been promising in terms of concrete results within each type of activity and together they provide vital steps in capacity-building in tertiary education to the benefit of development and environment. Some of the results and their implications are presented in this chapter and more are documented...... international aid programmes to tertiary education, including research and innovation in an interplay with other research institutions and business. In the absence of such support the so-called digital divide between industrial and developing and transition countries will widen, and brain-drain and poverty...

  19. Subsea gas transition hubs

    OpenAIRE

    Jakobsen, Pål Morten

    2014-01-01

    Gassco is the operator of two platforms with gas transport functions. These platforms are getting old and require large modifications to extend the lifetime and maintain their functions. Rapid development in subsea technology the recent years enables functions that earlier where performed by offshore platforms to be converted into subsea systems. Subsea developments offer the potential of reduced CAPEX, OPEX and risk reduction in terms of HSE. This makes subsea developments an attractive alte...

  20. Rural Health Information Hub

    Science.gov (United States)

    ... issues that impact rural health in RHIhub’s Topic Guides. Recently updated: Social Determinants of Health for Rural People Browse all 50+ topics Community Health Gateway Find rural project examples in Rural Health Models and Innovations and proven strategies for strong rural programs with ...

  1. Stochastic -robust optimization model and algorithm of multiple allocation hub set covering problem%多分配枢纽站集覆盖问题的随机��-鲁棒优化模型及算法

    Institute of Scientific and Technical Information of China (English)

    商丽媛; 谭清美

    2014-01-01

    The hub location is an important issue for the hub-and-spoke network optimization design, and hub covering is a type of the hub location problem. The uncertainty of the hub station construction costs and the uncertainty of the distance between two nodes are considered. The model of stochastic��-robust multiple allocation hub set covering problem is proposed with combination of stochastic optimization and robust optimization. Binary quantum-behaved particle swarm optimization algorithm is improved based on immunity thought. Immune quantum-behaved particle swarm optimization algorithm is proposed to solve the stochastic��-robust multiple allocation hub set covering model. The simulation example of this model is given, and the result shows the feasibility and effectiveness of the proposed model and algorithm.%枢纽站选址是轴辐式网络优化设计的重要问题,枢纽站覆盖则是该问题的一个类型。考虑枢纽站建站成本和节点间运输距离的不确定性,结合随机优化和鲁棒优化方法,建立了完备轴辐式网络中多分配枢纽站集覆盖问题的随机��-鲁棒优化模型;采用二进制编码,对量子粒子群算法进行改进,加入免疫思想,设计了免疫量子粒子群求解算法。最后通过算例对模型进行仿真计算,结果表明了该模型及算法的可行性和有效性。

  2. The degraded concept representation system in semantic dementia: damage to pan-modal hub, then visual spoke.

    Science.gov (United States)

    Hoffman, Paul; Jones, Roy W; Ralph, Matthew A Lambon

    2012-12-01

    explanation is consistent with a graded hub-and-spoke model of conceptual knowledge, in which there is a gradual convergence of information along the temporal lobes, with visual attributes represented in the posterior cortex giving way to pan-modal representations in the anterior areas.

  3. 基于资源优化的枢纽机场中转仿真%Simulation on Hub-Airport Transfer Based on Resources Optimization

    Institute of Scientific and Technical Information of China (English)

    张晓光; 朱金福; 陶婧婧

    2012-01-01

    机场资源的有限性是限制枢纽机场发展的最重要因素之一,如何能够提高中转资源的利用率已经成为改善枢纽机场中转运行效率的关键性问题.采用离散事件仿真技术根据中转航班旅客到达人数的变化实时分配中转资源,并使用SIMIO仿真软件实现了上海浦东国际机场的中转运行情况,以基于资源优化的思想,为每个航班动态指派中转资源.优化结果表明,实时分配的机场资源提高了中转资源的利用率.%An airport's resources are limited, which becomes one of the most important factors to limit the development of hub-airports. How to improve the resource utilization has become the key issue to improve the transfer efficiency of a hub airport. This paper used the method of discrete-event simulation to dynamic allocate the transfer resources according to the real-time change of the quantity of passengers arrival on the transfer flights, and simulated the transfer operation of Shanghai Pudong International Airport by using the simulation software SIMIO. This simulation dynamically assigned the transfer resources to each flight based on resources optimization. The optimization results show that the dynamic allocation of airport resources can improve the utilization of transfer resources, thus of the important reference for daily management of hub-airport.

  4. CFD analysis of rotating two-bladed flatback wind turbine rotor.

    Energy Technology Data Exchange (ETDEWEB)

    van Dam, C.P. (University of California, David, CA); Chao, David D.; Berg, Dale E. (University of California, David, CA)

    2008-04-01

    The effects of modifying the inboard portion of the NREL Phase VI rotor using a thickened, flatback version of the S809 design airfoil are studied using a three-dimensional Reynolds-averaged Navier-Stokes method. A motivation for using such a thicker airfoil design coupled with a blunt trailing edge is to alleviate structural constraints while reducing blade weight and maintaining the power performance of the rotor. The calculated results for the baseline Phase VI rotor are benchmarked against wind tunnel results obtained at 10, 7, and 5 meters per second. The calculated results for the modified rotor are compared against those of the baseline rotor. The results of this study demonstrate that a thick, flatback blade profile is viable as a bridge to connect structural requirements with aerodynamic performance in designing future wind turbine rotors.

  5. Transient power coefficients for a two-blade Savonius wind turbine

    Energy Technology Data Exchange (ETDEWEB)

    Pope, K.; Naterer, G. [Univ. of Ontario Inst. of Technology, Oshawa, ON (Canada). Faculty of Engineering and Applied Science

    2010-07-01

    The wind power industry had a 29 percent growth rate in installed capacity in 2008, and technological advances are helping to speed up growth by significantly increasing wind turbine power yields. While the majority of the industry's growth has come from large horizontal axis wind turbine installations, small wind turbines can also be used in a wide variety of applications. This study predicted the transient power coefficient for a Savonius vertical axis wind turbine (VAWT) wind turbine with 2 blades. The turbine's flow field was used to analyze pressure distribution along the rotor blades in relation to the momentum, lift, and drag forces on the rotor surfaces. The integral force balance was used to predict the transient torque and power output of the turbine. The study examined the implications of the addition of a second blade on the model's ability to predict transient power outputs. Computational fluid dynamics (CFD) programs were used to verify that the formulation can be used to accurately predict the transient power coefficients of VAWTs with Savonius blades. 11 refs., 1 tab., 6 figs.

  6. 转向前轴轮毂轴承游隙探讨分析%Analysis of Hub Bearing Clearance on Front Axle

    Institute of Scientific and Technical Information of China (English)

    刘德林

    2012-01-01

    This paper introduces the classification of hub bearing clearance on front axle, and the affect of clearance to bearing. Meanwhile discuss the adjust and test way of bearing clearance, cliff the bearing clearances between truck and bus front axles.%本文介绍了转向前轴轮毂轴承游隙的分类,游隙大小对轴承的影响,探讨了轴承游隙的调整与检测方法,区分了货车与客车前轴轴承游隙。

  7. InSilico DB genomic datasets hub: an efficient starting point for analyzing genome-wide studies in GenePattern, Integrative Genomics Viewer, and R/Bioconductor.

    Science.gov (United States)

    Coletta, Alain; Molter, Colin; Duqué, Robin; Steenhoff, David; Taminau, Jonatan; de Schaetzen, Virginie; Meganck, Stijn; Lazar, Cosmin; Venet, David; Detours, Vincent; Nowé, Ann; Bersini, Hugues; Weiss Solís, David Y

    2012-11-18

    Genomics datasets are increasingly useful for gaining biomedical insights, with adoption in the clinic underway. However, multiple hurdles related to data management stand in the way of their efficient large-scale utilization. The solution proposed is a web-based data storage hub. Having clear focus, flexibility and adaptability, InSilico DB seamlessly connects genomics dataset repositories to state-of-the-art and free GUI and command-line data analysis tools. The InSilico DB platform is a powerful collaborative environment, with advanced capabilities for biocuration, dataset sharing, and dataset subsetting and combination. InSilico DB is available from https://insilicodb.org.

  8. Volatile constituents of aerial parts of three endemic Centaurea species from Turkey: Centaurea amanicola Hub.-Mor., Centaurea consanguinea DC. and Centaurea ptosimopappa Hayek and their antibacterial activities.

    Science.gov (United States)

    Formisano, Carmen; Rigano, Daniela; Senatore, Felice; Celik, Sezgin; Bruno, Maurizio; Rosselli, Sergio

    2008-01-01

    The volatile constituents of the aerial parts of Centaurea amanicola Hub.-Mor., Centaurea consanguinea DC. and Centaurea ptosimopappa Hayek were extracted by hydrodistillation and analysed by GC and GC-MS. Altogether 94 components were identified. Sesquiterpenoids, fatty acids and carbonylic compounds were the most abundant components in the oils. Hexadecanoic acid and (Z,Z )-9,12-octadecadienoic acid were the main fatty acids in all the examined samples, that showed different patterns of composition. The study on the biological activity of the oils showed an action mainly against the Gram-positive pathogens.

  9. First year undergraduate nursing students and nursing mentors: An evaluation of their experience of specialist areas as their hub practice learning environment.

    Science.gov (United States)

    McCallum, Jacqueline; Lamont, David; Kerr, Emma-Louise

    2016-01-01

    Specialist environments have traditionally not been considered as practice learning environments for year one nursing students. Through implementation of the hub and spoke model of practice learning this was implemented across one health board and Higher Education Institution in Scotland. Sixty nine students from specialist and 147 from general areas out of a total population of 467 students (46.2%) and thirteen mentors from specialist and 26 from general areas out of a total 577 mentors (6.7%) completed a questionnaire. The findings support this initiative and suggest in some cases student experiences are more positive in specialist environments.

  10. Structural analysis of wind turbine rotors for NSF-NASA Mod-0 wind power system

    Science.gov (United States)

    Spera, D. A.

    1976-01-01

    Preliminary estimates are presented of vibratory loads and stresses in hingeless and teetering rotors for the proposed NSF-NASA Mod-0 wind power system. Preliminary blade design utilizes a tapered tubular aluminum spar which supports nonstructural aluminum ribs and skin and is joined to the rotor hub by a steel shank tube. Stresses in the shank of the blade are calculated for static, rated, and overload operating conditions. Blade vibrations were limited to the fundamental flapping modes, which were elastic cantilever bending for hingeless rotor blades and rigid-body rotation for teetering rotor blades. The MOSTAB-C computer code was used to calculate aerodynamic and mechanical loads. The teetering rotor has substantial advantages over the hingeless rotor with respect to shank stresses, fatigue life, and tower loading. The hingeless rotor analyzed does not appear to be structurally stable during overloads.

  11. Structures and short linear motif of disordered transcription factor regions provide clues to the interactome of the cellular hub radical-induced cell death1

    DEFF Research Database (Denmark)

    O'Shea, Charlotte; Staby, Lasse; Bendsen, Sidsel Krogh

    2017-01-01

    point to larger networks of interactions, such as with proteins that serve as hubs for essential cellular functions. The stress-associated plant protein Radical-Induced Cell Death1 (RCD1) is one such hub, interacting with many transcription factors via their flexible IDRs. To identify the SLiM bound...... by RCD1, we analyzed the IDRs in three protein partners - DREB2A, ANAC013, and ANAC046 - considering parameters such as disorder, context, charges, and pI. Using a combined bioinformatics and experimental approach, we have identified the bipartite RCD1-binding SLiM as [DE]-x(1,2)-[YF]-x(1,4)-[DE......]-L, with essential contributions from conserved aromatic, acidic, and leucine residues. Detailed thermodynamic analysis revealed both favorable and unfavorable contributions from the IDRs surrounding the SLiM to the interactions with RCD1, and the SLiM affinities ranged from low nanomolar to 50 times higher Kd...

  12. Network science and the human brain: Using graph theory to understand the brain and one of its hubs, the amygdala, in health and disease.

    Science.gov (United States)

    Mears, David; Pollard, Harvey B

    2016-06-01

    Over the past 15 years, the emerging field of network science has revealed the key features of brain networks, which include small-world topology, the presence of highly connected hubs, and hierarchical modularity. The value of network studies of the brain is underscored by the range of network alterations that have been identified in neurological and psychiatric disorders, including epilepsy, depression, Alzheimer's disease, schizophrenia, and many others. Here we briefly summarize the concepts of graph theory that are used to quantify network properties and describe common experimental approaches for analysis of brain networks of structural and functional connectivity. These range from tract tracing to functional magnetic resonance imaging, diffusion tensor imaging, electroencephalography, and magnetoencephalography. We then summarize the major findings from the application of graph theory to nervous systems ranging from Caenorhabditis elegans to more complex primate brains, including man. Focusing, then, on studies involving the amygdala, a brain region that has attracted intense interest as a center for emotional processing, fear, and motivation, we discuss the features of the amygdala in brain networks for fear conditioning and emotional perception. Finally, to highlight the utility of graph theory for studying dysfunction of the amygdala in mental illness, we review data with regard to changes in the hub properties of the amygdala in brain networks of patients with depression. We suggest that network studies of the human brain may serve to focus attention on regions and connections that act as principal drivers and controllers of brain function in health and disease.

  13. Discussion of Urban Underground Transportation Hub Fire Protection Design%城市地下交通枢纽消防设计探讨

    Institute of Scientific and Technical Information of China (English)

    孙乐祥; 林真国; 封红权

    2013-01-01

    城市地下交通枢纽是一种新型的城市地下交通系统,一旦发生事故将产生较为严重的后果。通过对城市地下交通枢纽的消防设计的探讨,分析了其消防设计中应该着重考虑的问题以及设计中的难点问题,包括防火分区的划分、火灾时的人员疏散、灭火系统的设计、防排烟系统的设计以及电气系统的设计。并结合实际工程做进一步的探讨。%Urban underground transport hub is a new urban underground transport system. An accident will result in more serious consequences. Based on the discussion of urban underground transport hub fire protection design and according to the analysis, we found what issues should be considered and the difficult issues of the design, including the division of fire district, fire evacuation, fire fighting system design, smoke control system design and electrical system design. Then we combined fire protection design with practical work to do a further study.

  14. Preprocessing of Software Defect Data Based on GitHub%基于GitHub的软件缺陷数据预处理

    Institute of Scientific and Technical Information of China (English)

    类兴明; 杨春花

    2016-01-01

    缺陷数据是进行软件缺陷相关领域研究的基础。针对当前缺陷数据源受到获取方式与数据来源的局限等问题,设计并实现了一个软件缺陷数据预处理系统。实现对指定的GitHub上的项目的缺陷数据源进行获取、预处理及管理。通过该系统,用户可以方便地获取GitHub上自己所期望的项目的缺陷数据集。%Defect data is the basis of the relevant research in the field of software defects. In view of the defect data restricted by acquisition mode and data sources limitations and other issues, there are independent design and development of the software defect data pretreatment system. In this paper, a system is designed and implemented to acquire, preprocess, and manage the defect data source for the specified projects located on GitHub.Through the system,users can easily obtain an expected defect data collection on GitHub.

  15. Design and Analysis on Vibration Reduction System in Electric Vehicles with Hub Motor%电动车辆轮毂电机减振系统设计与分析

    Institute of Scientific and Technical Information of China (English)

    魏亚鹏; 吴胜涛; 马英; 秦鹏鹏; 李浩冉; 张汉召

    2015-01-01

    为消除轮毂电机造成电动汽车非簧载质量增加而使车辆平顺性和安全性降低的影响,根据质量转移的方法,在电动轮内安装弹簧阻尼减振系统将轮毂电机质量变成吸振器,建立11自由度电动轮车辆整车动力学模型,并对模型进行仿真分析。结果表明,轮毂电机减振系统在满足轮毂电机垂向跳动要求的基础上,可以消除轮毂电机刚性与车轮连接给车辆带来的垂向负效应问题。%In order to eliminate the reduction effect of vehicle ride comfort and safety of the hub motor electric vehi-cle caused by the under spring mass increased, according to the method of mass transfer, the authors mount the spring damping vibration system in the electric wheels to make the hub motor mass the vibration absorber, establish dynamics model of 11 freedom degree vehicle with hub motor, and simulate the model. The results show that the damping system of the hub motor on the basis of meeting the requirements of hub motor vertical jump can eliminate the negative vertical effect of the vehicle because of the hub motor rigidly connected to the wheel.

  16. Pedestrian Simulation in Transportation Hub Based on NOMAD Model%基于NOMAD模型的交通枢纽行人仿真研究

    Institute of Scientific and Technical Information of China (English)

    张蕊; 杨静; 韩冬; 雷熙文

    2011-01-01

    在分析交通枢纽内行人交通特性的基础上,探讨了基于社会力原理的NOMAD模型的分层结构、输入条件以及模型构建思路,指出其非常适于进行交通枢纽内行人行为微观仿真以及行人设施评价.根据交通调查数据对NOMAD行人仿真模型的参数进行了标定,利用标定后的NOMAD模型对复兴门换乘枢纽建立仿真模型,分析了该枢纽的性能特点,获得了与换乘系统相关的量化参数,通过仿真数据与观测数据的对比分析可知,利用NOMAD模型能很好地模拟所研究的换乘枢纽内行人换乘行为特性,模型模拟结果与实际观测数据之间的相对误差均在10%以内,验证了NOMAD模型应用于交通枢纽行人仿真的有效性.%After the characteristics analysis of pedestrian in transportation hub, the social-force based NOMAD model is found to be very suitable for micro-simulation of pedestrian behavior and evaluation of pedestrian facilities. In addition, the hierarchical structure, input conditions and model building ideas of the NOMAD model is proposed. Furthermore, some important parameters are calibrated based on traffic survey data, then the Fuxingmen transfer station is simulated by the model. Based on the simulation results, characteristics of this station are analyzed and some quantization parameters that associate with the transfer system are obtained. By comparing simulation data and observational data, NOMAD model is found to be well adopted to the simulation of pedestrian transfer behavioral characteristics in the transfer hub. The relative error between simulation and observational data is less than 10%. It verifies the validity of applying NOMAD model for pedestrian simulation in transportation hub.

  17. The fast code

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, L.N.; Wilson, R.E. [Oregon State Univ., Dept. of Mechanical Engineering, Corvallis, OR (United States)

    1996-09-01

    The FAST Code which is capable of determining structural loads on a flexible, teetering, horizontal axis wind turbine is described and comparisons of calculated loads with test data are given at two wind speeds for the ESI-80. The FAST Code models a two-bladed HAWT with degrees of freedom for blade bending, teeter, drive train flexibility, yaw, and windwise and crosswind tower motion. The code allows blade dimensions, stiffnesses, and weights to differ and models tower shadow, wind shear, and turbulence. Additionally, dynamic stall is included as are delta-3 and an underslung rotor. Load comparisons are made with ESI-80 test data in the form of power spectral density, rainflow counting, occurrence histograms, and azimuth averaged bin plots. It is concluded that agreement between the FAST Code and test results is good. (au)

  18. Non-essential genes form the hubs of genome scale protein function and environmental gene expression networks in Salmonella enterica serovar Typhimurium

    DEFF Research Database (Denmark)

    Rosenkrantz, Jesper T.; Aarts, Henk; Abee, Tjakko

    2013-01-01

    Background: Salmonella Typhimurium is an important pathogen of human and animals. It shows a broad growth range and survives in harsh conditions. The aim of this study was to analyze transcriptional responses to a number of growth and stress conditions as well as the relationship of metabolic...... pathways and/or cell functions at the genome-scale-level by network analysis, and further to explore whether highly connected genes ( hubs) in these networks were essential for growth, stress adaptation and virulence. Results: De novo generated as well as published transcriptional data for 425 selected...... genes under a number of growth and stress conditions were used to construct a bipartite network connecting culture conditions and significantly regulated genes (transcriptional network). Also, a genome scale network was constructed for strain LT2. The latter connected genes with metabolic pathways...

  19. Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks.

    Science.gov (United States)

    Frame, Nicholas M; Gursky, Olga

    2016-03-01

    Serum amyloid A is a major acute-phase plasma protein that modulates innate immunity and cholesterol homeostasis. We combine sequence analysis with x-ray crystal structures to postulate that SAA acts as an intrinsically disordered hub mediating interactions among proteins, lipids and proteoglycans. A structural model of lipoprotein-bound SAA monomer is proposed wherein two α-helices from the N-domain form a concave hydrophobic surface that binds lipoproteins. A C-domain, connected to the N-domain via a flexible linker, binds polar/charged ligands including cell receptors, bridging them with lipoproteins and rerouting cholesterol transport. Our model is supported by the SAA cleavage in the interdomain linker to generate the 1-76 fragment deposited in reactive amyloidosis. This model sheds new light on functions of this enigmatic protein. © 2016 Federation of European Biochemical Societies.

  20. Dynamic interactions in terms of senders, hubs, and receivers (SHR) using the singular value decomposition of time series: Theory and brain connectivity applications

    CERN Document Server

    Pascual-Marqui, Roberto D

    2010-01-01

    Understanding of normal and pathological brain function requires the identification and localization of functional connections between specialized regions. The availability of high time resolution signals of electric neuronal activity at several regions offers information for quantifying the connections in terms of information flow. When the signals cover the whole cortex, the number of connections is very large, making visualization and interpretation very difficult. We introduce here the singular value decomposition of time-lagged multiple signals, which localizes the senders, hubs, and receivers (SHR) of information transmission. Unlike methods that operate on large connectivity matrices, such as correlation thresholding and graph-theoretic analyses, this method operates on the multiple time series directly, providing 3D brain images that assign a score to each location in terms of its sending, relaying, and receiving capacity. The scope of the method is general and encompasses other applications outside t...

  1. Study on Supply Hub Mode in Supply Chain Environment%供应链环境下Supply Hub模式研究

    Institute of Scientific and Technical Information of China (English)

    杭明升; 汪小京

    2011-01-01

    In this paper, the principle of supply hub management is introduced after a description of its concept, then its operational mode and functionalities are discussed in detail as well as its operation processes, and finally a case analysis is included to illustrate the prior points made in this paper.%Supplyhub运作模式是供应链物流的一种创新模式.在界定supplyhub概念的基础上阐述了supply hub的管理思想,并详细讨论了supply hub的运作模式及实现的功能,分析了supply hub的运作流程,为企业实施supply hub提供有效借鉴.

  2. Seguimiento de proyectos de programación. Una aplicación de GitHub en la educación

    OpenAIRE

    Javier Salazar Zárate; Blanca Hidalgo Ponce; Narcisa Salazar Alvarez; Byron Vaca Barahona

    2016-01-01

    Esta investigación desarrolla y propone un método para la ejecución y se-guimiento de los proyectos de fin de curso de las materias de lenguajes de programación en carreras de Ingeniería Electrónica soportado tecnológica-mente por GitHub. El objetivo es obtener un método que permita mejorar la calidad de los proyectos. Para la validación del nuevo método se realiza un contraste entre dos grupos de estudiantes, el primer grupo utilizando el mé-todo tradicional de ejecución de proyectos y el se...

  3. 城市交通枢纽节能设计研究%RESEARCH ON ENERGY- SAVING MEASURE FOR URBAN TRANSPORT HUB

    Institute of Scientific and Technical Information of China (English)

    李贺楠; 韩丹

    2014-01-01

    According to the present situation of high energy consumption for urban comprehensive transport hub, the project team makes a research on the comprehensive transport hub established in the small and medium-sized cities. This article makes a discussion on the main factors of high energy consumption and proposes the energy saving measures on the aspects of intensive space design, building mass design, shading design of maintenance structure, lighting design of the roof, use of solar panels and so on. Based on BIM technology, the design schemes can be analyzed, compared and optimized by using the Vasari and GBS building energy simulation software.%针对目前交通枢纽能耗大的现状,笔者课题组对京沪、京广沿线已建成的中小型城市交通枢纽进行实地调研。本文从空间集约化设计、建筑形体设计、围护结构遮阳设计、屋顶采光设计、室内吊顶空间以及新材料利用等方面分析城市交通枢纽能耗大的原因,并提出了节能措施,并基于BIM技术,采用GBS建筑能耗模拟软件,对设计方案进行分析、对比和优化。

  4. Automatic extracting topic page links from Hub page%中心网页中主题网页链接的自动抽取

    Institute of Scientific and Technical Information of China (English)

    夏天

    2012-01-01

    基于扩展标记树,提出了一种从中心网页中自动抽取主题网页链接的方法。首先构建链接有序表,利用链接前缀树发现主题网页链接拒绝规则,实现对网页链接类型的预判定;其次,通过分组分割和相似分组重新合并,把页面中的链接归入到不同分组之中,进而识别分组的类型和核心区域所在的分组,最终把链接归入三类链接集合之中。实验结果表明该方法无需训练即可实现中心网页中主题网页链接的高精度抽取。%A topic link extraction method from Hub page based on extended label tree was proposed.Firs,a topic link sorted list was build and deny rules were learned by prefix tree,then,the link type was pre-determined.Second,by group splitting and re-merging,each candidate link was classified into different groups.The group type and the group which represented the hub page's core region were identified,and finally all links were put into three different collections.Experimental results show that this method can achieve high-precision for topic link extraction without training.

  5. Analysis on Failure of Hub Bearing Greases at Altiplano Area%高原地区车辆轮毂轴承润滑脂流失失效原因分析

    Institute of Scientific and Technical Information of China (English)

    米红英; 陈德友; 郭小川; 刘庆廉; 吴宝杰

    2011-01-01

    The failure of hub bearing grease were analysised by calculating the quantity of grease running off from the hub bearing was? Researching the rheological parameters of the grease, calculating the temperature field of hub bearing using imitating system. Laboratory examination was carried out, the hub bearing field tests were carried out on the plateau freight truck, the test methods of grease' s performance characteristics were studied. It was brought forward that it is effective to cope with the grease running off by improving the lubricating grease's elastic modulus, apparent viscosity and yield shear stresses.%通过轮毂轴承润滑脂流失理论计算及流变学研究、轮毂轴承温度场模拟仿真,分析了车辆轮毂轴承润滑脂流失失效原因,进行了实验室验证试验、行车验证试验及轮毂轴承润滑脂使用性能评定方法研究,提出了解决车辆轮毂轴承润滑脂流失失效的方法.

  6. 铁路客运枢纽旅客离站换乘决策方法研究%Study on Decision-making Method of Passenger Transfer in Railway Hub

    Institute of Scientific and Technical Information of China (English)

    彭群洁; 徐良杰

    2013-01-01

    为了分析铁路客运枢纽旅客换乘选择交通方式出行比例和旅客站内换乘可达性,建立铁路客运枢纽离站系统通道与换乘站点之间的联系,从铁路客运枢纽的布局模式、离站旅客特征分析角度出发,确立影响旅客交通方式决策和换乘可达性影响因子,并以武昌火车站为例分析,建立交通方式换乘选择非集计模型和旅客站内换乘时间可达模型.%To analyze the proportion of traffic mode choice and accessibility of passengers transferring inside the railway hub and establish the connection of exiting corridors and mode-transferring nodes, the paper research on the layout mode and passengers characteristics in the railway passenger hub, and make sure the influencing factors of traffic mode decision-making and transferring accessibility. Taking Wuchang railway station as instance, the traffic mode disaggregate choice model and transferring-time accessibility model are established for passengers in the railway hub, which is useful to analyze the hub's transfer efficiency and layout rationality.

  7. A Study on the Fatigue Life of Hub Bearings in Front Steering Axle of a Heavy Duty Truck%重型载货汽车转向前桥轮毂轴承疲劳寿命的研究

    Institute of Scientific and Technical Information of China (English)

    王国权; 张红松; 张良城

    2012-01-01

    为揭示重型载货汽车转向前桥轮毂轴承寿命不长的原因,制定了轮毂轴承寿命分析的汽车行驶工况,确定了相应的载荷谱.以Lundberg-Palmgren和Ioannidis-Harris轴承寿命理论为依据,用Romax软件建立了轮毂轴承疲劳寿命分析模型,计算了7.5t转向前桥额定载荷时轮毂轴承的疲劳寿命和损伤率.结果表明,轮毂内轴承满足设计要求,但轮毂外轴承均不满足设计要求.其中寿命最短的右侧轮毂外轴承,内、外国有明显的错位,滚子承载不均匀,内圈挡肩上轴向载荷的合力方向偏离旋转轴线,产生弯曲力矩,内、外圈存在严重的应力集中.%To reveal the reason for the short life of hub bearings in the front steering axle of a heavy duty truck, the vehicle driving conditions for hub bearing life analysis is worked out with their corresponding load spectra defined. Based on Lundberg-Palmgren and Ioannidis-Harris bearing life theories, a fatigue life analysis model for hub bearings is established with Romax software, and the fatigue life and the damage rate of hub bearings in a 7. 5 t front steering axle under rated loading conditions are calculated. The results show that the inner bearing in inner wheel hub meets the design requirements, but the bearings in outer wheel hub don't. Among them the bearing in right outer wheel hub has the shortest life, and there is apparent misalignment between its inner and outer rings with uneven roller loads. Moreover, the direction of resultant force of axial loads acting on inner ring rib deviates from rotating axis, generating bending moment and causing severe stress concentration in both inner and outer rings.

  8. Lot Sizes Coordination among a Manufacturer and Two Suppliers Based on Supply-Hub%基于Supply-hub的2个供应商单制造商批量协调问题研究

    Institute of Scientific and Technical Information of China (English)

    桂华明; 马士华; 关旭; 张林兰

    2012-01-01

    Considering an assembly-type supply chain consisting of two suppliers and a manufacturer, the cost functions of them are established. Moreover, the production and order quantity models are proposed respectively by the manufacturer and two suppliers responsible for the supply-hub's operation and costs. The results show that when the manufacturer is responsible for the supply-hub's operation, the farther the suppliers are from the supply-hub, the greater the manufacturer's production quantity is, and the replenishing lot-sizes of parts to the supply-hub are greater compared to the manufacturer being responsible for the supply-hub's operation. When two suppliers are responsible for the supply-hub's operation, the production quantities of the manufacturer and suppliers do not vary with the distance between suppliers and supply-hub. Moreover, in the conditions for using supply-hub model, compared to the manufacturer, the suppliers are responsible for supply-hub operation and costs, which may make the whole supply chain to achieve Pareto optimization since the manufacturer and suppliers can obtain a win-win solution.%考虑一个由2个供应商和单制造商组成的装配型供应链,分析并建立了制造商、Supply-hub和2个供应商的平均成本函数,提出了分别由制造商和2个供应商负责Supply-hub营运及成本时的生产与订货批量模型.研究结果表明:当由制造商负责时,供应商距离Supply-hub越远,制造商的生产批量越大,且Supply-hub中的零部件补货批量相比供应商负责时更大;当由供应商负责时,制造商的生产批量不随供应商的远近而变化,供应商的零部件生产批量也不变.此外,在适用Supply-hub的条件下,相比由制造商负责,由2个供应商负责Supply-hub的运营并分担其成本时,整个供应链的总成本更低,2个供应商与制造商之间可以通过合理分配使2个供应商与制造商的营运成本均有所降低,从而实现整个供应链系统的Pareto优化.

  9. Effect of control activity on blade fatigue damage rate for a small horizontal axis wind turbine

    Energy Technology Data Exchange (ETDEWEB)

    Riddle, A.F.; Freris, L.L.; Graham, J.M.R. [Imperial College, London (United Kingdom)

    1996-09-01

    An experiment into the effect of control activity on blade fatigue damage rate for a 5 kW, two bladed, teetered HAWT has been performed. It has been shown that control activity influences the distribution of strain in the blade but that in a high rotor speed, high cycle fatigue regime this has little influence on damage rate. The experiment was conducted on a small test turbine by implementing variable speed stall, pitch and yaw control strategies and measuring blade flapwise strain response at root and midspan locations. A full description of the investigation is provided. (au)

  10. The comparisons of lot sizes and costs based on the different bodies responsible for supply -hub operations%不同Supply—hub营运主体下的批量与成本比较研究

    Institute of Scientific and Technical Information of China (English)

    桂华明; 马士华

    2012-01-01

    The supply pattern based on supply -hub under the Just -In -Time (JIT) environment is considered, and the average cost function of manufacturer, supply - huh, and supplier is established. Moreover, the production and order lot - size models of the supply - hub operation and cost, which manufacturer and supplier are responsible for, respectively, are proposed. The results show that under the condition that supply - hub is appropriate,it is more favorable to the supplier than to the manufacturer when the supplier is responsible for supply - hub operation and cost comparing with the manufacturer is responsible for, but the total cost of the supply chain is reduced. It is able to reduce the costs of the manufacturer and the supplier on certain level through negotiations and interest transfer, therefore entire supply chain is achieved Pareto optimization; Moreover, with the distance between the supplier and supply - hub is the further, it is more favorable to the supply chain when the supplier is responsible for supply - hub operation and cost rather than the manufacturer is responsible for that.%本文考虑了JIT环境下基于Supply—hub的供货模式,建立了制造商、Supply—hub和供应商的平均成本函数,并提出了分别由制造商和供应商负责Supply—hub营运及成本的生产与订货批量模型。结果表明,在Supply—hub适用的条件下,相比由制造商负责,供应商负责Supply—hub的运营及成本时,对供应商有利而不利于制造商,但整个供应链的总成本减少,通过供应商与制造商之间的协商和利益转移,可以使制造商和供应商的成本都有所减少,从而实现整个供应链的Pareto优化,此外,供应商距离Supply—hub越远,相比制造商负责,由供应商负责Supply—hub的营运及成本对整个供应链更有利。

  11. 综合客运枢纽布局规划要点及编制指引%The Planning Points and Guidelines of the Comprehensive Passenger Transport Hub

    Institute of Scientific and Technical Information of China (English)

    张小辉; 过秀成; 杜小川; 邓润飞

    2013-01-01

    In the rapid process of the integrated passenger transport system and urbanization, integrated passenger transport hub layout planning has important significance to promote the formation of an integrated transport system and to guide the development of urban space also to improve the level of transportation services. The paper analyzes the management mechanism of the hub planning, starting from the concept connotation and basic characteristics of the integrated passenger transport hub to the areas of integrated passenger transport hub layout planning. It presented the major concerns and contents of the hub planning at the national level, the provincial level and city-level. And it pays main attention to the planning framework and technical guidelines of integrated passenger transport hub planning at the city level, and in the end the paper proposes some suggestions and recommendations about the planning formulation.%在综合运输体系、城市化进程尚处在快速发展阶段,综合客运枢纽布局规划对促进综合运输体系形成、引导城市空间发展、提高运输服务水平具有重要现实意义。本文分析了各类枢纽规划的管理机制,从综合客运枢纽的概念内涵和基本特征分析出发,引出综合客运枢纽布局规划的要点,提出在国家层面、省级层面和地市层面枢纽规划关注的主要问题和落脚点,重点研究了地市层面综合客运枢纽规划编制的主要框架和技术指引,并提出规划编制的相关保障措施。

  12. Regional expression of the MAPT gene is associated with loss of hubs in brain networks and cognitive impairment in Parkinson disease and progressive supranuclear palsy.

    Science.gov (United States)

    Rittman, Timothy; Rubinov, Mikail; Vértes, Petra E; Patel, Ameera X; Ginestet, Cedric E; Ghosh, Boyd C P; Barker, Roger A; Spillantini, Maria Grazia; Bullmore, Edward T; Rowe, James B

    2016-12-01

    Abnormalities of tau protein are central to the pathogenesis of progressive supranuclear palsy, whereas haplotype variation of the tau gene MAPT influences the risk of Parkinson disease and Parkinson's disease dementia. We assessed whether regional MAPT expression might be associated with selective vulnerability of global brain networks to neurodegenerative pathology. Using task-free functional magnetic resonance imaging in progressive supranuclear palsy, Parkinson disease, and healthy subjects (n = 128), we examined functional brain networks and measured the connection strength between 471 gray matter regions. We obtained MAPT and SNCA microarray expression data in healthy subjects from the Allen brain atlas. Regional connectivity varied according to the normal expression of MAPT. The regional expression of MAPT correlated with the proportionate loss of regional connectivity in Parkinson's disease. Executive cognition was impaired in proportion to the loss of hub connectivity. These effects were not seen with SNCA, suggesting that alpha-synuclein pathology is not mediated through global network properties. The results establish a link between regional MAPT expression and selective vulnerability of functional brain networks to neurodegeneration.

  13. [Current Status of Community Pharmacies: Expectations as a Health Information Hub, the Enforcement of Revised Pharmaceutical and Medical Device Act, and a New Role as Stakeholders].

    Science.gov (United States)

    Saito, Mitsuo

    2016-01-01

    According to the "Japan Revitalization Strategy" established in June 2013, "the government will promote better contributions of local pharmacies and pharmacists in encouraging self-medication of citizens by making pharmacies the community-based hub for providing information, giving advice on the proper use of non-prescription drugs, etc. and offering consultation and information service concerning health". In addition, the "Demanded Function and Ideal Form of Pharmacy," published in January 2014, requested a change, from pharmacies that specialized in dispensing medicines to pharmacies that serve as whole healthcare stations, providing pharmaceutical care based on patients' medical history, including the intake of dietary supplements. The medication fee was revised in April 2014 to enhance family pharmacy services and the management of pharmaceutical care. At that time, blood testing at a registered pharmacy was officially allowed under strict regulation. Revision of the "Pharmacist Law" in June 2014 included a request to pharmacists to provide pharmaceutical advice in addition to information. For the mitigation of drug-induced tragedies, the "Pharmaceutical Affairs Law" was amended to the "Pharmaceutical and Medical Device Act (PMD Act)" in November 2014, and proper use of medicines was imposed on healthcare professionals and other stakeholders. Patients were also requested to learn and understand the safety and harmful effects of medicines, and were requested to use medicines appropriately. As mentioned above, the status of pharmacies and pharmacists has dramatically changed in the past 2 years, and such changes over time are required.

  14. Competitiveness of Small Farms and Innovative Food Supply Chains: The Role of Food Hubs in Creating Sustainable Regional and Local Food Systems

    Directory of Open Access Journals (Sweden)

    Giaime Berti

    2016-07-01

    Full Text Available Over the last decades, the economic, social and environmental sustainability of the conventional agri-food system has and continues to be contested within both academic and public institutions. For small farms, the unsustainability of the food system is even more serious; farms’ declining share of profit and the cost-price squeeze of commodity production has increased barriers to market access with the inevitable effect of agricultural abandonment. One way forward to respond to the existing conventional agri-food systems and to create a competitive or survival strategy for small family farms is the re-construction of regional and local agri-food systems, aligning with Kramer and Porter’s concept of shared value strategy. Through a critical literature review, this paper presents “regional and local food hubs” as innovative organizational arrangements capable of bridging structural holes in the agri-food markets between small producers and the consumers—individuals and families as well as big buyers. Food hubs respond to a supply chain (or supply network organizational strategy aiming at re-territorialising the agri-food systems through the construction of what in the economic literature are defined as values-based food supply chains.

  15. 5'HS5 of the human beta-globin locus control region is dispensable for the formation of the beta-globin active chromatin hub.

    Directory of Open Access Journals (Sweden)

    Ping Kei Chan

    Full Text Available Hypersensitive site 5 (5'HS5 of the beta-globin Locus Control Region functions as a developmental stage-specific border in erythroid cells. Here, we have analyzed the role of 5'HS5 in the three dimensional organization of the beta-gene locus using the Chromatin Conformation Capture (3C technique. The results show that when 5'HS5 is deleted from the locus, both remote and internal regulatory elements are still able to interact with each other in a three-dimensional configuration termed the Active Chromatin Hub. Thus, the absence of 5'HS5 does not have an appreciable effect on the three dimensional organization of the beta-globin locus. This rules out models in which 5'HS5 nucleates interactions with remote and/or internal regulatory elements. We also determined the binding of CTCF, the only defined insulator protein in mammalian cells, to 5'HS5 by using chromatin immunoprecipitation (ChIP assays. We detect low levels of CTCF binding to 5'HS5 in primitive erythroid cells, in which it functions as a border element. Surprisingly, we also observe binding levels of CTCF to 5'HS5 in definitive erythroid cells. Thus, binding of CTCF to 5'HS5 per se does not render it a functional border element. This is consistent with the previous data suggesting that CTCF has dual functionality.

  16. Novel and environmental friendly approach; Impact of Neem (Azadirachta indica) gum nano formulation (NGNF) on Helicoverpa armigera (Hub.) and Spodoptera litura (Fab.).

    Science.gov (United States)

    Kamaraj, Chinnaperumal; Gandhi, Pachiyappan Rajiv; Elango, Gandhi; Karthi, Sengodan; Chung, Ill-Min; Rajakumar, Govindasamy

    2017-08-30

    The future of this study was to prepare a natural pesticide which will not harm the environment and yet control pests. Neem gum nano formulation (NGNF), a novel biopesticide prepared from the Neem gum extract (Azadirachta indica) (NGE) was evaluated for its antifeedant, larvicidal and pupicidal activities against Helicoverpa armigera (Hub.) and Spodoptera litura (Fab.) at 100ppm. The NGNF showed significant (100%) antifeedant, larvicidal and pupicidal activities against H. armigera and S. litura. The LC50 values of 10.20, 12.49 and LC90 values of 32.68, 36.68ppm on H. armigera and S. litura, respectively at 100ppm. The NGNF treatments showed differences in the activities of detoxifying enzymes, carboxylesterases, glucosidases and glutathione S-transferases in the larval gut. Earthworm toxicity illustrated that 6.25ppm of chemical insecticides (cypermethrin) varied widely in their contact toxicities compared to 100ppm of NGNF and control in both contact filter paper and artificial soil test. The NGNF were characterized and confirmed by FTIR, XRD, SEM and EDX analysis. Ten compounds were identified from the Neem gum extract (NGE) by Gas Chromatography-Mass Spectrometry (GC-MS) analysis. The major compounds were fatty acids like Hexadecanoic acid, oleic acid, and ricinoleic acid. NGNF could be used as an agent to prepare novel bio-pesticides formulations. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Integrated network analysis identifies fight-club nodes as a class of hubs encompassing key putative switch genes that induce major transcriptome reprogramming during grapevine development.

    Science.gov (United States)

    Palumbo, Maria Concetta; Zenoni, Sara; Fasoli, Marianna; Massonnet, Mélanie; Farina, Lorenzo; Castiglione, Filippo; Pezzotti, Mario; Paci, Paola

    2014-12-01

    We developed an approach that integrates different network-based methods to analyze the correlation network arising from large-scale gene expression data. By studying grapevine (Vitis vinifera) and tomato (Solanum lycopersicum) gene expression atlases and a grapevine berry transcriptomic data set during the transition from immature to mature growth, we identified a category named "fight-club hubs" characterized by a marked negative correlation with the expression profiles of neighboring genes in the network. A special subset named "switch genes" was identified, with the additional property of many significant negative correlations outside their own group in the network. Switch genes are involved in multiple processes and include transcription factors that may be considered master regulators of the previously reported transcriptome remodeling that marks the developmental shift from immature to mature growth. All switch genes, expressed at low levels in vegetative/green tissues, showed a significant increase in mature/woody organs, suggesting a potential regulatory role during the developmental transition. Finally, our analysis of tomato gene expression data sets showed that wild-type switch genes are downregulated in ripening-deficient mutants. The identification of known master regulators of tomato fruit maturation suggests our method is suitable for the detection of key regulators of organ development in different fleshy fruit crops.

  18. agINFRA: a research data hub for agriculture, food and the environment [v2; ref status: indexed, http://f1000r.es/5hk

    Directory of Open Access Journals (Sweden)

    Andreas Drakos

    2015-06-01

    Full Text Available The agINFRA project (www.aginfra.eu was a European Commission funded project under the 7th Framework Programme that aimed to introduce agricultural scientific communities to the vision of open and participatory data-intensive science. agINFRA has now evolved into the European hub for data-powered research on agriculture, food and the environment, serving the research community through multiple roles. Working on enhancing the interoperability between heterogeneous data sources, the agINFRA project has left a set of grid- and cloud- based services that can be reused by future initiatives and adopted by existing ones, in order to facilitate the dissemination of agricultural research, educational and other types of data. On top of that, agINFRA provided a set of domain-specific recommendations for the publication of agri-food research outcomes. This paper discusses the concept of the agINFRA project and presents its major outcomes, as adopted by existing initiatives activated in the context of agricultural research and education.

  19. 某直升机主桨毂下垂限动器离心配重优化设计%Main Hub Centrifugal Weight’ s Optimal Design

    Institute of Scientific and Technical Information of China (English)

    陈少峰; 李建伟; 孙文芳

    2016-01-01

    某型机两架机在开车过程中出现异常振动,停机后检查发现主桨毂部分支臂下垂限动器的离心配重限位凸台断裂。论文通过设计复查和下垂限动器工作原理分析,明确了下垂限动器的离心配重限位凸台断裂的故障原因,对离心配重进行了优化设计,经外场使用初步验证,优化措施有效。%Two planes appeared abnormal vibration during driving. It's shown that the main hub part of arm droop limit actuator centrifugal weight limit convex platform to be fractured after the stop ex-amination. According to the fault, through inspecting the decomposition of failure parts and analy-zing the drooping stopper principle, determined the reason of the Centrifugal Weight’ s break. And Optimal Designed the Centrifugal Weight, the optimal measure was effective through the preliminary validation of outdoor test.

  20. Brain Tumor Epidemiology - A Hub within Multidisciplinary Neuro-oncology. Report on the 15th Brain Tumor Epidemiology Consortium (BTEC) Annual Meeting, Vienna, 2014.

    Science.gov (United States)

    Woehrer, Adelheid; Lau, Ching C; Prayer, Daniela; Bauchet, Luc; Rosenfeld, Myrna; Capper, David; Fisher, Paul G; Kool, Marcel; Müller, Martin; Kros, Johan M; Kruchko, Carol; Wiemels, Joseph; Wrensch, Margaret; Danysh, Heather E; Zouaoui, Sonia; Heck, Julia E; Johnson, Kimberly J; Qi, Xiaoyang; O'Neill, Brian P; Afzal, Samina; Scheurer, Michael E; Bainbridge, Matthew N; Nousome, Darryl; Bahassi, El Mustapha; Hainfellner, Johannes A; Barnholtz-Sloan, Jill S

    2015-01-01

    The Brain Tumor Epidemiology Consortium (BTEC) is an open scientific forum, which fosters the development of multi-center, international and inter-disciplinary collaborations. BTEC aims to develop a better understanding of the etiology, outcomes, and prevention of brain tumors (http://epi.grants.cancer.gov/btec/). The 15th annual Brain Tumor Epidemiology Consortium Meeting, hosted by the Austrian Societies of Neuropathology and Neuro-oncology, was held on September 9 - 11, 2014 in Vienna, Austria. The meeting focused on the central role of brain tumor epidemiology within multidisciplinary neuro-oncology. Knowledge of disease incidence, outcomes, as well as risk factors is fundamental to all fields involved in research and treatment of patients with brain tumors; thus, epidemiology constitutes an important link between disciplines, indeed the very hub. This was reflected by the scientific program, which included various sessions linking brain tumor epidemiology with clinical neuro-oncology, tissue-based research, and cancer registration. Renowned experts from Europe and the United States contributed their personal perspectives stimulating further group discussions. Several concrete action plans evolved for the group to move forward until next year's meeting, which will be held at the Mayo Clinic at Rochester, MN, USA.