WorldWideScience

Sample records for two-adjacent half-space slp

  1. Dirichlet Problem on the Upper Half Space

    Indian Academy of Sciences (India)

    Dewu Yang; Yudong Ren

    2014-05-01

    In this paper, a solution of the Dirichlet problem on the upper half space for a fast growing continuous boundary function is constructed by the generalized Dirichlet integral with this boundary function.

  2. Some intriguing properties of Tukey's half-space depth

    CERN Document Server

    Dutta, Subhajit; Chaudhuri, Probal; 10.3150/10-BEJ322

    2012-01-01

    For multivariate data, Tukey's half-space depth is one of the most popular depth functions available in the literature. It is conceptually simple and satisfies several desirable properties of depth functions. The Tukey median, the multivariate median associated with the half-space depth, is also a well-known measure of center for multivariate data with several interesting properties. In this article, we derive and investigate some interesting properties of half-space depth and its associated multivariate median. These properties, some of which are counterintuitive, have important statistical consequences in multivariate analysis. We also investigate a natural extension of Tukey's half-space depth and the related median for probability distributions on any Banach space (which may be finite- or infinite-dimensional) and prove some results that demonstrate anomalous behavior of half-space depth in infinite-dimensional spaces.

  3. Plane Strain Deformation of a Poroelastic Half-space in Welded Contact with Transversely Isotropic Elastic Half-Space

    Directory of Open Access Journals (Sweden)

    NEELAM KUMARI

    2012-11-01

    Full Text Available The Biot linearized theory for fluid saturated porous materials is used to study the plane strain deformation of an isotropic, homogeneous, poroelastPic half space in welded contact with a homogeneous, transversely isotropic, elastic half space caused by an inclined line-load in elastic half space. The integral expressions for the displacements and stresses in the two half spaces in welded contact are obtained from the corresponding expressions for an unbounded transversely isotropic elastic and poroelastic medium by applying boundary conditions at the interface. The integrals for the inclined line-load are solved analytically for the limiting casei.e. undrained conditions in high frequency limit. The undrained displacements, stresses and pore pressure are shown graphically. Expression for the pore pressure is also calculated for undrained conditions in the high frequency limit.

  4. New Poisson's Type Integral Formula for Thermoelastic Half-Space

    Directory of Open Access Journals (Sweden)

    Victor Seremet

    2009-01-01

    Full Text Available A new Green's function and a new Poisson's type integral formula for a boundary value problem (BVP in thermoelasticity for a half-space with mixed boundary conditions are derived. The thermoelastic displacements are generated by a heat source, applied in the inner points of the half-space and by temperature, and prescribed on its boundary. All results are obtained in closed forms that are formulated in a special theorem. A closed form solution for a particular BVP of thermoelasticity for a half-space also is included. The main difficulties to obtain these results are in deriving of functions of influence of a unit concentrated force onto elastic volume dilatation Θ( and, also, in calculating of a volume integral of the product of function Θ( and Green's function in heat conduction. Using the proposed approach, it is possible to extend the obtained results not only for any canonical Cartesian domain, but also for any orthogonal one.

  5. Motion of a Vortex Filament in the Half Space

    CERN Document Server

    Aiki, Masashi

    2010-01-01

    A model equation for the motion of a vortex filament immersed in three dimensional, incompressible and inviscid fluid is investigated as a humble attempt to model the motion of a tornado. We solve an initial-boundary value problem in the half space where we impose a boundary condition in which the vortex filament is allowed to move on the boundary.

  6. Surface waves on a quantum plasma half-space

    CERN Document Server

    Lázár, M; Smolyakov, A

    2007-01-01

    Surface modes are coupled electromagnetic/electrostatic excitations of free electrons near the vacuum-plasma interface and can be excited on a sufficiently dense plasma half-space. They propagate along the surface plane and decay in either sides of the boundary. In such dense plasma models, which are of interest in electronic signal transmission or in some astrophysical applications, the dynamics of the electrons is certainly affected by the quantum effects. Thus, the dispersion relation for the surface wave on a quantum electron plasma half-space is derived by employing the quantum hydrodynamical (QHD) and Maxwell-Poison equations. The QHD include quantum forces involving the Fermi electron temperature and the quantum Bohm potential. It is found that, at room temperature, the quantum effects are mainly relevant for the electrostatic surface plasma waves in a dense gold metallic plasma.

  7. LibHalfSpace: A C++ object-oriented library to study deformation and stress in elastic half-spaces

    Science.gov (United States)

    Ferrari, Claudio; Bonafede, Maurizio; Belardinelli, Maria Elina

    2016-11-01

    The study of deformation processes in elastic half-spaces is widely employed for many purposes (e.g. didactic, scientific investigation of real processes, inversion of geodetic data, etc.). We present a coherent programming interface containing a set of tools designed to make easier and faster the study of processes in an elastic half-space. LibHalfSpace is presented in the form of an object-oriented library. A set of well known and frequently used source models (Mogi source, penny shaped horizontal crack, inflating spheroid, Okada rectangular dislocation, etc.) are implemented to describe the potential usage and the versatility of the library. The common interface given to library tools enables us to switch easily among the effects produced by different deformation sources that can be monitored at the free surface. Furthermore, the library also offers an interface which simplifies the creation of new source models exploiting the features of object-oriented programming (OOP). These source models can be built as distributions of rectangular boundary elements. In order to better explain how new models can be deployed some examples are included in the library.

  8. Osteoid Osteoma of Cervical Spine in two adjacent Vertebrae

    Directory of Open Access Journals (Sweden)

    MR Etemadifar

    2005-09-01

    Full Text Available Osteoid osteoma is a benign bone tumor, mainly seen in 10-30 years male. Spine is a relatively common site and almost always, posterior elements are involved. Plain X-Ray-, CT scan and Isotope scan help to identify and localize spine lesions. We described one 18 years old boy with 3 years low neck pain. Isotope scan, MRI and CT scan showed two lesions in C7 and T1. Gross inspection and histopathology examination confirmed osteoid osteoma in two adjacent vertebrae which has not been reported elsewhere in the literature. Key words: Osteoid Osteoma, Spine, Multifocal

  9. Radiative Albedo from a Linearly Fibered Half Space

    CERN Document Server

    Grzesik, J A

    2016-01-01

    A growing acceptance of fiber reinforced composite materials imparts some relevance to exploring the effects which a predominantly linear scattering lattice may have upon interior radiant transport. Indeed, a central feature of electromagnetic wave propagation within such a lattice, if sufficiently dilute, is ray confinement to cones whose half-angles are set by that between lattice and the incident ray. When such propagation is subordinated to a viewpoint of photon transport, one arrives at a somewhat simplified variant of the Boltzmann equation with spherical scattering demoted to its cylindrical counterpart. With a view to initiating a hopefully wider discussion of such phenomena, we follow through in detail the half-space albedo problem. This is done first along canonical lines that harness the Wiener-Hopf technique, and then once more in a discrete ordinates setting via flux decomposition along the eigenbasis of the underlying attenuation/scattering matrix. Good agreement is seen to prevail. We further s...

  10. Reconstruction of faults in elastic half space from surface measurements

    Science.gov (United States)

    Volkov, Darko; Voisin, Christophe; Ionescu, Ioan R.

    2017-05-01

    We study in this paper a half-space linear elasticity model for surface displacements caused by slip along underground faults. We prove uniqueness of the fault location and (piecewise-planar) geometry and of the slip field for a given surface displacement field. We then introduce a reconstruction algorithm for the realistic case where only a finite number of surface measurements are available. After showing how this algorithm performs on simulated data and assessing the effect of noise, we apply it to measured data. The data were recorded during slow slip events in Guerrero, Mexico. Since this is a well studied subduction zone, it is possible to compare our inferred fault geometry to other reconstructions (obtained using different techniques) found in the literature.

  11. Soil Structure Interaction between Two Adjacent Buildings under Earthquake Load

    Directory of Open Access Journals (Sweden)

    Mahmoud Yahyai

    2008-01-01

    Full Text Available In some cases, tall buildings are located in geotechnically unsuitable places, due to their high ratio of height to width; there is risk of uplift and other effects such as overturning and reduction structure serviceability during earthquake. This research is aimed to evaluate the effect of Soil-Structure Interaction (SSI on seismic behavior of two adjacent 32 story buildings such as time period, base shear and displacements. The interaction effects are investigated for variable distance between the two buildings. Three types of soil such as soft clay, sandy gravel and compacted sandy gravel are considered for this study. The result obtained that the interaction effect increases time period of both buildings base shear and lateral displacement of the structures increases.

  12. Wave propagation in solid and porous half-space media

    CERN Document Server

    Hamidzadeh, Hamid R; Jazar, Reza N

    2014-01-01

    This unique book covers advanced topics in dynamic modeling of soil-foundation interaction, as well as the response of elastic semi-infinite media from an applications viewpoint. Advanced concepts such as solutions for analysis of elastic semi-infinite mediums, fluid motion in porous media, and nonlinearities in dynamic behavior are explained in great detail. Related theories and numerical analysis for independent vertical, horizontal, and rocking as well as coupled horizontal and rocking vibrations of a rigid rectangular base resting on the surface of a semi-infinite medium are presented. Throughout the book, a strong emphasis is placed on applications. A laboratory model for elastic half-space medium is also described. This book also: ·         Provides a systematic solution for analysis of elastic semi-infinite mediums when subjected to different loading conditions ·         Offers a solution for the continuous elastic medium that is also extended to visco-elastic media by considering com...

  13. Effect of dynamic visco-elasticity on vertical and torsional vibrations of a half-space

    Indian Academy of Sciences (India)

    Prakash Chandra Pal

    2001-08-01

    By expressing the dynamic visco-elastic characteristic of a material in terms of the complex shear modulus, the vertical vibrations of a visco-elastic half-space as well as that of a mass in visco-elastic half-space are considered here. Torsional vibrations of a visco-elastic half-space is also considered. Numerical results are derived for two cases and shown graphically.

  14. Antiplane contact problem for elastic half-space with cracks and stringers

    Directory of Open Access Journals (Sweden)

    Aghayan K.L

    2016-03-01

    Full Text Available The contact problem of load transfer of a thin elastic plate to the elastic half-space is considered. The half-space weakened by a system of finite length collinear tunnel cracks which are perpendicular to the half-space boundary. The border of half-space reinforced by stringers. By external forces applied to the plates and the banks of the cracks, the half-space - plate system deformed under antiplane strain. In the frame of well-known Melan model for stringer the solution of the problem is reduced to a system of singular integral equations, whose solution is built by numerically - analytical method of mechanical quadratures. The behavior of the contact stresses and stress intensity factors at the crack tip and the end points of stringers is investigated.

  15. Dispersion of Love Waves in a Composite Layer Resting on Monoclinic Half-Space

    Directory of Open Access Journals (Sweden)

    Sukumar Saha

    2011-01-01

    Full Text Available Dispersion of Love waves is studied in a fibre-reinforced layer resting on monoclinic half-space. The wave velocity equation has been obtained for a fiber-reinforced layer resting on monoclinic half space. Shear wave velocity ratio curve for Love waves has been shown graphically for fibre reinforced material layer resting on various monoclinic half-spaces. In a similar way, shear wave velocity ratio curve for Love waves has been plotted for an isotropic layer resting on various monoclinic half-spaces. From these curves, it has been observed that the curves are of similar type for a fibre reinforced layer resting on monoclinic half-spaces, and the shear wave velocity ratio ranges from 1.14 to 7.19, whereas for the case isotropic layer, this range varies from 1.0 to 2.19.

  16. Static deformation due to a long buried dip-slip fault in an isotropic half-space welded with an orthotropic half-space

    Indian Academy of Sciences (India)

    Neeru Bala; Sunita Rani

    2009-12-01

    Closed-form analytical expressions for the displacements and the stresses at any point of a two-phase medium consisting of a homogeneous, isotropic, perfectly elastic half-space in welded contact with a homogeneous, orthotropic, perfectly elastic half-space due to a dip-slip fault of finite width located at an arbitrary distance from the interface in the isotropic half-space are obtained. The Airy stress function approach is used to obtain the expressions for the stresses and the displacements. The case of a vertical dip-slip fault is considered in detail. The variations of the displacements with the distance from the fault and with depth have been shown graphically.

  17. Transmission of longitudinal wave at a plane interface between micropolar elastic and chiral solid half-spaces: Incidence from micropolar half-space

    Science.gov (United States)

    Khurana, Aarti; Tomar, S. K.

    2008-04-01

    Reflection and transmission phenomena of a plane longitudinal displacement wave impinging obliquely at a plane interface between a micropolar elastic solid half-space and a chiral elastic solid half-space are investigated. The incident wave is assumed to be striking at the plane interface after propagating through the micropolar elastic solid half-space. The reflection and transmission coefficients are obtained by utilizing two possible sets of boundary conditions, for a specific model and there values corresponding to two boundary conditions are also compared graphically. The effect of chirality parameter on various reflection and transmission coefficients have been noticed and shown graphically. Results of Lakhtakia et al. [Reflection of elastic plane waves at a planar achiral-chiral interface, Journal of the Acoustical Society of America 87 (1990) 2314-2318] and Miklowitz [The Theory of Elastic Waves and Waveguides, North-Holland, New York, 1978] have also been reduced as special cases from the present formulation.

  18. Quasi-static deformation due to two-dimensional seismic sources embedded in an elastic half-space in welded contact with a poroelastic half-space

    Indian Academy of Sciences (India)

    Sunita Rani; Sarva Jit Singh

    2007-04-01

    The Biot linearized theory of fluid saturated porous materials is used to study the plane strain deformation of a two-phase medium consisting of a homogeneous, isotropic, poroelastic half-space in welded contact with a homogeneous, isotropic, perfectly elastic half-space caused by a twodimensional source in the elastic half-space. The integral expressions for the displacements and stresses in the two half-spaces in welded contact are obtained from the corresponding expressions for an unbounded elastic medium by applying suitable boundary conditions at the interface. The case of a long dip-slip fault is discussed in detail. The integrals for this source are solved analytically for two limiting cases: (i) undrained conditions in the high frequency limit, and (ii) steady state drained conditions as the frequency approaches zero. It has been verified that the solution for the drained case ( → 0) coincides with the known elastic solution. The drained and undrained displacements and stresses are compared graphically. Diffusion of the pore pressure with time is also studied.

  19. Deformation of a layered half-space due to a very long tensile fault

    Indian Academy of Sciences (India)

    Sarva Jit Singh; Mahabir Singh

    2004-06-01

    The problem of the coseismic deformation of an earth model consisting of an elastic layer of uniform thickness overlying an elastic half-space due to a very long tensile fault in the layer is solved analytically. Integral expressions for the surface displacements are obtained for a vertical tensile fault and a horizontal tensile fault. The integrals involved are evaluated approximately by using Sneddon's method of replacing the integrand by a finite sum of exponential terms. Detailed numerical results showing the variation of the displacements with epicentral distance for various source locations in the layer are presented graphically. The displacement field in the layered half-space is compared with the corresponding field in a uniform half-space to demonstrate the effect of the internal boundary. Relaxed rigidity method is used for computing the postseismic deformation of an earth model consisting of an elastic layer of uniform thickness overlying a viscoelastic half-space.

  20. Treatment Outcome and Patient Satisfaction with Two Adjacent Implant-Supported Restorations in the Esthetic Zone

    NARCIS (Netherlands)

    Tymstra, Nynke; Meijer, Henny J. A.; Stellingsma, Kees; Raghoebar, Gerry M.; Vissink, Arjan

    2010-01-01

    The purpose of this study was to evaluate the clinical and radiographic parameters as well as the esthetic outcome of two adjacent implant-supported restorations and the surrounding peri-implant mucosa in the maxillary esthetic zone. Ten patients were treated with two adjacent implants in the anteri

  1. ON THE LOWER BOUND FOR A CLASS OF HARMONIC FUNCTIONS IN THE HALF SPACE

    Institute of Scientific and Technical Information of China (English)

    Zhang Yanhui; Deng Guantie; Kou Kit Ian

    2012-01-01

    The main objective is to derive a lower bound from an upper one for harmonic functions in the half space,which extends a result of B.Y.Levin from dimension 2 to dimension n ≥ 2.To this end,we first generalize the Carleman's formula for harmonic functions in the half plane to higher dimensional half space,and then establish a Nevanlinna's representation for harmonic functions in the half sphere by using H(ǒ)rmander's theorem.

  2. Rayleigh Waves in a Rotating Orthotropic Micropolar Elastic Solid Half-Space

    Directory of Open Access Journals (Sweden)

    Baljeet Singh

    2013-01-01

    Full Text Available A problem on Rayleigh wave in a rotating half-space of an orthotropic micropolar material is considered. The governing equations are solved for surface wave solutions in the half space of the material. These solutions satisfy the boundary conditions at free surface of the half-space to obtain the frequency equation of the Rayleigh wave. For numerical purpose, the frequency equation is approximated. The nondimensional speed of Rayleigh wave is computed and shown graphically versus nondimensional frequency and rotation-frequency ratio for both orthotropic micropolar elastic and isotropic micropolar elastic cases. The numerical results show the effects of rotation, orthotropy, and nondimensional frequency on the nondimensional speed of the Rayleigh wave.

  3. Foundation plate on the elastic half-space, deterministic and probabilistic approach

    Directory of Open Access Journals (Sweden)

    Tvrdá Katarína

    2017-01-01

    Full Text Available Interaction between the foundation plate and subgrade can be described by different mathematical - physical model. Elastic foundation can be modelled by different types of models, e.g. one-parametric model, two-parametric model and a comprehensive model - Boussinesque (elastic half-space had been used. The article deals with deterministic and probabilistic analysis of deflection of the foundation plate on the elastic half-space. Contact between the foundation plate and subsoil was modelled using contact elements node-node. At the end the obtained results are presented.

  4. Holographic microscopy reconstruction in both object and image half spaces with undistorted 3D grid

    CERN Document Server

    Verrier, Nicolas; Tessier, Gilles; Gross, Michel

    2015-01-01

    We propose a holographic microscopy reconstruction method, which propagates the hologram, in the object half space, in the vicinity of the object. The calibration yields reconstructions with an undistorted reconstruction grid i.e. with orthogonal x, y and z axis and constant pixels pitch. The method is validated with an USAF target imaged by a x60 microscope objective, whose holograms are recorded and reconstructed for different USAF locations along the longitudinal axis:-75 to +75 {\\mu}m. Since the reconstruction numerical phase mask, the reference phase curvature and MO form an afocal device, the reconstruction can be interpreted as occurring equivalently in the object or in image half space.

  5. Application of generalized impedance boundary conditions to sommerfeld half-space problem

    Institute of Scientific and Technical Information of China (English)

    JIANG Bin-hao; LIU Yong-tan

    2005-01-01

    Generalized impedance boundary conditions are employed to simplify the solution of the Sommerfeld half-space problem. An analytical expression is derived for the Hertz potential of a vertical electric dipole over the earth's surface, in which the earth is assumed to be a layered media or homogeneous dissipative half-space.A Sommerfeld type integral in the potential function is expressed as the sum of two parts: a zeroth order Hankel function and an absolutely convergent series of Bessel functions. In addition, two expressions in closed form are obtained as the far-field and near-field approximation of the present result.

  6. Vertical vibrations of elastic foundation resting on saturated half-space

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    This paper is mainly concerned with the dynamic response of an elastic foundation of finite height bounded to the surface of a saturated half-space.The foundation is subjected to time-harmonic vertical loadings.First, the transform solutions for the governing equations of the saturated media are obtained.Then, based on the assumption that the contact between the foundation and the half-space is fully relaxed and the half-space is completely pervious or impervious, this dynamic mixed boundary-value problem can lead to dual integral equations, which can be further reduced to the Fredholm integral equations of the second kind and solved by numerical procedures.In the numerical examplea, the dynamic compliances, displacements and pore pressure are developed for a wide range of frequencies and material/geometrical properties of the saturated soil-foundation system.In most of the cases, the dynamic behavior of an elastic foundation resting on the saturated media significantly differs from that of a rigid disc on the saturated half-space.The solutions obtained can be used to study a variety of wave propagation problems and dynamic soil-structure interactions.

  7. Vibration of an Elastic Circular Plate on an Elastic Half Space

    DEFF Research Database (Denmark)

    Krenk, Steen; Schmidt, H.

    1981-01-01

    The axisymmetric problem of a vibrating elastic plate on an elastic half space is solved by a direct method, in which the contact stresses and the normal displacements of the plate are taken as the unknown functions. First, the influence functions that give the displacements in terms...... influence from the elastic properties of the plate....

  8. Global Heat Kernel Estimates for $\\Delta+\\Delta^{\\alpha/2}$ in Half-space-like domains

    CERN Document Server

    Chen, Zhen-Qing; Song, Renming

    2011-01-01

    Suppose that $d\\ge 1$ and $\\alpha\\in (0, 2)$. In this paper, by using probabilistic methods, we establish sharp two-sided pointwise estimates for the Dirichlet heat kernels of $\\{\\Delta+ a^\\alpha \\Delta^{\\alpha/2}; \\ a\\in (0, 1]\\}$ on half-space-like $C^{1, 1}$ domains in ${\\mathbb R}^d$ for all time $t>0$. The large time estimates for half-space-like domains are very different from those for bounded domains. Our estimates are uniform in $a \\in (0, 1]$ in the sense that the constants in the estimates are independent of $a\\in (0, 1]$. Thus it yields the Dirichlet heat kernel estimates for Brownian motion in half-space-like domains by taking $a\\to 0$. Integrating the heat kernel estimates in time $t$, we obtain uniform sharp two-sided estimates for the Green functions of $\\{\\Delta+ a^\\alpha \\Delta^{\\alpha/2}; \\ a\\in (0, 1]\\}$ in half-space-like $C^{1, 1}$ domains in ${\\mathbb R}^d$.

  9. Thermal field diffusion in one, two and three-dimensional half space

    Directory of Open Access Journals (Sweden)

    Cividjian Grigore A.

    2011-01-01

    Full Text Available The diffusion of suddenly occurring local high temperature in homogeneous half-infinite space is studied in the cases of one, two and three-dimensional half space. Comparison of the three cases is made. Applications of theoretically analyzed models are suggested. Errors induced by assumptions are evaluated.

  10. Stokes' first problem for the fourth order fluid in a porous half space

    Institute of Scientific and Technical Information of China (English)

    T.Hayat; F.Shahazad; M.Ayub

    2007-01-01

    In this study, the flow of a fourth order fluid in a porous half space is modeled. By using the modified Darcy's law, the flow over a suddenly moving flat plate is studied numerically. The influence of various param-eters of interest on the velocity profile is revealed.

  11. STEADY-STATE RESPONSE OF A TIMOSHENKO BEAM ON AN ELASTIC HALF-SPACE UNDER A MOVING LOAD

    Institute of Scientific and Technical Information of China (English)

    Chen Yunmin; Wang Changjing

    2006-01-01

    By introducing the equivalent stiffness of an elastic half-space interacting with a Timoshenko beam, the displacement solution of the beam resting on an elastic half-space subjected to a moving load is presented. Based on the relative relation of wave velocities of the half-space and the beam, four cases with the combination of different parameters of the half-space and the beam, the system of soft beam and hard half-space, the system of sub-soft beam and hard halfspace, the system of sub-hard beam and soft half-space, and the system of hard beam and soft half-space are considered. The critical velocities of the moving load are studied using dispersion curves. It is found that critical velocities of the moving load on the Timoshenko beam depend on the relative relation of wave velocities of the half-space and the beam. The Rayleigh wave velocity in the half-space is always a critical velocity and the response of the system will be infinite when the load velocity reaches it. For the system of soft beam and hard half-space, wave velocities of the beam are also critical velocities. Besides the shear wave velocity of the beam, there is an additional minimum critical velocity for the system of sub-soft beam and hard half-space. While for systems of (sub-) hard beams and soft half-space, wave velocities of the beam are no longer critical ones.Comparison with the Euler-Bernoulli beam shows that the critical velocities and response of the two types of beams are much different for the system of (sub-) soft beam and hard half-space but are similar to each other for the system of (sub-) hard beam and soft half space. The largest displacement of the beam is almost at the location of the load and the displacement along the beam is almost symmetrical if the load velocity is smaller than the minimum critical velocity (the shear wave velocity of the beam for the system of soft beam and hard half-space). The largest displacement of the beam shifts behind the load and the asymmetry

  12. Static deformation of two welded monoclinic elastic half-spaces due to a long inclined strike-slip fault

    Indian Academy of Sciences (India)

    Anil Kumar; Sarvajit Singh; Jagdish Singh

    2002-06-01

    Static deformation of two monoclinic elastic half-spaces in welded contact due to a long inclined strike-slip fault situated in one of the half-spaces is studied analytically and numerically. Closedform algebraic expressions for the displacement at any point of the medium are obtained. The variation of the displacement at the interface with the horizontal distance from the fault is studied. The effect of anisotropy on the displacement field is examined. It is found that while the anisotropy of the source half-space has a significant effect on the displacement at the interface, the anisotropy of the other half-space has only a marginal effect.

  13. Analytical solution of thermoelastic interaction in a half-space by pulsed laser heating

    Science.gov (United States)

    Abbas, Ibrahim A.; Marin, Marin

    2017-03-01

    In this article, we consider the problem of a two-dimensional thermoelastic half-space in the context of generalized thermoelastic theory with one relaxation time. The surface of the half-space is taken to be traction free and thermally insulated. The solution of the considered physical quantity can be broken down in terms of normal modes. The nonhomogeneous basic equations have been written in the form of a vector-matrix differential equation, which is then solved by an eigenvalue approach. The exact analytical solution is adopted for the temperature, the components of displacement and stresses. The results obtained are presented graphically for the effect of laser pulse to display the phenomena physical meaning. The graphical results indicate that the thermal relaxation time has a great effect on the temperature, the components of displacement and the components of stress.

  14. Rayleigh-type waves in nonlocal micropolar solid half-space.

    Science.gov (United States)

    Khurana, Aarti; Tomar, S K

    2017-01-01

    Propagation of Rayleigh type surface waves in nonlocal micropolar elastic solid half-space has been investigated. Two modes of Rayleigh-type waves are found to propagate under certain approximations. Frequency equations of these Rayleigh type modes and their conditions of existence have been derived. These frequency equations are found to be dispersive in character due to the presence of micropolarity and nonlocality parameters in the medium. One of the frequency equations is a counterpart of the classical Rayleigh waves and the other is new and has appeared due to micropolarity of the medium. Phase speeds of these waves are computed numerically for Magnesium crystal and their variation against wavenumber are presented graphically. Comparisons have been made between the phase speeds of Rayleigh type waves through nonlocal micropolar, local micropolar and elastic solid half-spaces. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Deformation of two welded elastic half-spaces due to a long inclined tensile fault

    Indian Academy of Sciences (India)

    Anil Kumar; Sarva Jit Singh; Jagdish Singh

    2005-02-01

    The calculation of the deformation caused by shear and tensile faults is necessary for the investigation of seismic and volcanic sources. The solution of the two-dimensional problem of a long inclined shear fault in two welded half-spaces is well known. The purpose of this note is to present the corresponding solution for a tensile fault. Closed-form analytical expressions for the Airy stress function for a tensile line source in two welded half-spaces are first obtained. These expressions are then integrated analytically to derive the Airy stress function for a long tensile fault of arbitrary dip and finite width. Closed-form analytical expressions for the displacements and stresses follow immediately from the Airy stress function. These expressions are suitable for computing the displacement and stress fields around a long inclined tensile fault near an internal boundary.

  16. Converting Boundary Representation Solid Models to Half-Space Representation Models for Monte Carlo Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Davis JE, Eddy MJ, Sutton TM, Altomari TJ

    2007-03-01

    Solid modeling computer software systems provide for the design of three-dimensional solid models used in the design and analysis of physical components. The current state-of-the-art in solid modeling representation uses a boundary representation format in which geometry and topology are used to form three-dimensional boundaries of the solid. The geometry representation used in these systems is cubic B-spline curves and surfaces--a network of cubic B-spline functions in three-dimensional Cartesian coordinate space. Many Monte Carlo codes, however, use a geometry representation in which geometry units are specified by intersections and unions of half-spaces. This paper describes an algorithm for converting from a boundary representation to a half-space representation.

  17. Plane strain deformation of a multi-layered poroelastic half-space by surface loads

    Indian Academy of Sciences (India)

    Sarva Jit Singh; Sunita Rani

    2006-12-01

    The Biot linearized quasi-static theory of fluid-infiltrated porous materials is used to formulate the problem of the two-dimensional plane strain deformation of a multi-layered poroelastic half-space by surface loads. The Fourier–Laplace transforms of the stresses, displacements, pore pressure and fluid flux in each homogeneous layer of the multi-layered half-space are expressed in terms of six arbitrary constants. Generalized Thomson–Haskell matrix method is used to obtain the deformation field. Simplified explicit expressions for the elements of the 6 × 6 propagator matrix for the poroelastic medium are obtained. As an example of the possible applications of the analytical formulation developed, formal solution is given for normal strip loading, normal line loading and shear line loading.

  18. Hybrid Male Sterility in Rice Controlled by Interaction between Divergent Alleles of Two Adjacent Genes

    National Research Council Canada - National Science Library

    Yunming Long; Lifeng Zhao; Baixiao Niu; Jing Su; Hao Wu; Yuanling Chen; Qunyu Zhang; Jingxin Guo; Chuxiong Zhuang; Mantong Mei; Jixing Xia; Lan Wang; Haibin Wu; Yao-Guang Liu

    2008-01-01

    .... Here we show that a locus for indica-japonica hybrid male sterility, Sa, comprises two adjacent genes, SaM and SaF, encoding a small ubiquitin-like modifier E3 ligase-like protein and an F-box protein, respectively...

  19. Asymptotic Behavior for a Class of Modified -Potentials in a Half Space

    Directory of Open Access Journals (Sweden)

    Deng Guantie

    2010-01-01

    Full Text Available A class of -potentials represented as the sum of modified Green potential and modified Poisson integral are proved to have the growth estimates at infinity in the upper-half space of the -dimensional Euclidean space, where the function is a positive non-decreasing function on the interval satisfying certain conditions. This result generalizes the growth properties of analytic functions, harmonic functions, and superharmonic functions.

  20. Wave propagation through an inhomogeneous slab sandwiched by the piezoelectric and the piezomagnetic half spaces.

    Science.gov (United States)

    Jiao, Fengyu; Wei, Peijun; Li, Li

    2017-01-01

    Wave propagation through a gradient slab sandwiched by the piezoelectric and the piezomagnetic half spaces are studied in this paper. First, the secular equations in the transverse isotropic piezoelectric/piezomagnetic half spaces are derived from the general dynamic equation. Then, the state vectors at piezoelectric and piezomagnetic half spaces are related to the amplitudes of various possible waves. The state transfer equation of the functionally graded slab is derived from the equations of motion by the reduction of order, and the transfer matrix of the functionally gradient slab is obtained by solving the state transfer equation with the spatial-varying coefficient. Finally, the continuous interface conditions are used to lead to the resultant algebraic equations. The algebraic equations are solved to obtain the amplitude ratios of various waves which are further used to obtain the energy reflection and transmission coefficients of various waves. The numerical results are shown graphically and are validated by the energy conservation law. Based on the numerical results on the fives of gradient profiles, the influences of the graded slab on the wave propagation are discussed. It is found that the reflection and transmission coefficients are obviously dependent upon the gradient profile. The various surface waves are more sensitive to the gradient profile than the bulk waves.

  1. Dynamic Maintenance of Half-Space Depth for Points and Contours

    CERN Document Server

    Burr, Michael A; Souvaine, Diane L

    2011-01-01

    Half-space depth (also called Tukey depth or location depth) is one of the most commonly studied data depth measures because it possesses many desirable properties for data depth functions. The data depth contours bound regions of increasing depth. For the sample case, there are two competing definitions of contours: the rank-based contours and the cover-based contours. In this paper, we present three dynamic algorithms for maintaining the half-space depth of points and contours: The first maintains the half-space depth of a single point in a data set in $O(\\log n)$ time per update (insertion/deletion) and overall linear space. By maintaining such a data structure for each data point, we present an algorithm for dynamically maintaining the rank-based contours in $O(n\\cdot\\log n)$ time per update and overall quadratic space. The third dynamic algorithm maintains the cover-based contours in $O(n\\cdot \\log^2 n)$ time per update and overall quadratic space. We also augment our first algorithm to maintain the loca...

  2. Diffraction of SH-waves by topographic features in a layered transversely isotropic half-space

    Science.gov (United States)

    Ba, Zhenning; Liang, Jianwen; Zhang, Yanju

    2017-01-01

    The scattering of plane SH-waves by topographic features in a layered transversely isotropic (TI) half-space is investigated by using an indirect boundary element method (IBEM). Firstly, the anti-plane dynamic stiffness matrix of the layered TI half-space is established and the free fields are solved by using the direct stiffness method. Then, Green's functions are derived for uniformly distributed loads acting on an inclined line in a layered TI half-space and the scattered fields are constructed with the deduced Green's functions. Finally, the free fields are added to the scattered ones to obtain the global dynamic responses. The method is verified by comparing results with the published isotropic ones. Both the steady-state and transient dynamic responses are evaluated and discussed. Numerical results in the frequency domain show that surface motions for the TI media can be significantly different from those for the isotropic case, which are strongly dependent on the anisotropy property, incident angle and incident frequency. Results in the time domain show that the material anisotropy has important effects on the maximum duration and maximum amplitudes of the time histories.

  3. An Effective Method for Free Vibration of Plate on Elastic Half Space

    Institute of Scientific and Technical Information of China (English)

    Wang Yuanhan; Gong Wenhui

    2004-01-01

    The vibration analysis of a plate on an elastic foundation is an important problem in engineering. It is the interaction of a plate with the three-dimensional half space and the plate is usually loaded from both the upper and lower surfaces. The contact pressure from the soil can not be predefined. According to Lamb's solution for a single oscillating force acting on a point on the surface of an elastic half space, and the relevant approximation formulae, a relation between the local pressure and the deflection of the plate has been proposed. Based on this analysis, the reaction of the soil can be represented as the deformation of the plate. Therefore, the plate can be separated from the soil and only needs to be divided by a number of elements in the analysis. The following procedure is the same as the standard finite element method. This is a semi-analytical and semi-numerical method. It has been applied to the dynamic analysis of circular or rectangular plates on the elastic half space, at low or high frequency vibration, and on rigid, soft or flexible foundations. The results show that this method is versatile and highly accurate.

  4. Magneto-thermoelastic waves in a perfectly conducting elastic half-space in thermoelasticity III

    Directory of Open Access Journals (Sweden)

    S. K. Roychoudhuri

    2005-01-01

    Full Text Available The propagation of magneto-thermoelastic disturbances in an elastic half-space caused by the application of a thermal shock on the stress-free bounding surface in contact with vacuum is investigated. The theory of thermoelasticity III proposed by Green and Naghdi is used to study the interaction between elastic, thermal, and magnetic fields. Small-time approximations of solutions for displacement, temperature, stress, perturbed magnetic fields both in the vacuum and in the half-space are derived. The solutions for displacement, temperature, stress, perturbed magnetic field in the solid consist of a dilatational wave front with attenuation depending on magneto-thermoelastic coupling and also consists of a part diffusive in nature due to the damping term present in the heat transport equation, while the perturbed field in vacuum represents a wave front without attenuation traveling with Alfv'en acoustic wave speed. Displacement and temperatures are continuous at the elastic wave front, while both the stress and the perturbed magnetic field in the half-space suffer finite jumps at this location. Numerical results for a copper-like material are presented.

  5. A wideband fast multipole boundary element method for half-space/plane-symmetric acoustic wave problems

    Institute of Scientific and Technical Information of China (English)

    Chang-Jun Zheng; Hai-Bo Chen; Lei-Lei Chen

    2013-01-01

    This paper presents a novel wideband fast multipole boundary element approach to 3D half-space/planesymmetric acoustic wave problems.The half-space fundamental solution is employed in the boundary integral equations so that the tree structure required in the fast multipole algorithm is constructed for the boundary elements in the real domain only.Moreover,a set of symmetric relations between the multipole expansion coefficients of the real and image domains are derived,and the half-space fundamental solution is modified for the purpose of applying such relations to avoid calculating,translating and saving the multipole/local expansion coefficients of the image domain.The wideband adaptive multilevel fast multipole algorithm associated with the iterative solver GMRES is employed so that the present method is accurate and efficient for both lowand high-frequency acoustic wave problems.As for exterior acoustic problems,the Burton-Miller method is adopted to tackle the fictitious eigenfrequency problem involved in the conventional boundary integral equation method.Details on the implementation of the present method are described,and numerical examples are given to demonstrate its accuracy and efficiency.

  6. Flexible Connection Elastomeric Rubber as a Pounding Resisting Element between Two Adjacent Buildings

    Directory of Open Access Journals (Sweden)

    Yuskar Lase

    2013-03-01

    Full Text Available To solve pounding problem of two adjacent buildings, structural designer usually employs a dilatation between the structures or make the two structures as a monolith structure. Other alternative is by using an elastomeric rubber as a pounding resisting element between the two structures. Effectiveness in applying elastomeric rubber component as flexible connection of two adjacent structures is the main focus of this paper. Various simulations such as structure models, earthquake excitations and openings in gap element are studied. Observation of maximum structural responses will be performed for structure model with elastomeric rubber in comparison with (1 monolith structure model and (2 structure model with rigid element (steel element. Simulation results show that application of elastomeric rubber component to prevent structures from pounding problem provides advantages especially in reducing internal forces in the shorter building. However, it slightly increases displacement of both structures.

  7. Health and function assessments in two adjacent Danish birth cohorts of centenarians

    DEFF Research Database (Denmark)

    Vestergaard, Sonja; Andersen-Ranberg, Karen; Skytthe, Axel;

    2016-01-01

    Using the results from measures of functional ability, cognitive and physical performance from two adjacent birth cohorts of 100-year-old adults, we aimed to elucidate the possible impact of difference in participation rates, design, and interviewer mode. Participants were birth cohort members born...... in terms of ADL and cognitive functioning. Caution is warranted when comparing studies of centenarians with different participation rates, design, and interviewer mode, and further studies of these methodological issues are required....

  8. Analytical Expressions for Deformation from an Arbitrarily Oriented Spheroid in a Half-Space

    Science.gov (United States)

    Cervelli, P. F.

    2013-12-01

    Deformation from magma chambers can be modeled by an elastic half-space with an embedded cavity subject to uniform pressure change along its interior surface. For a small number of cavity shapes, such as a sphere or a prolate spheroid, closed-form, analytical expressions for deformation have been derived, although these only approximate the uniform-pressure-change boundary condition, with the approximation becoming more accurate as the ratio of source depth to source dimension increases. Using the method of Elshelby [1957] and Yang [1988], which consists of a distribution of double forces and centers of dilatation along the vertical axis, I have derived expressions for displacement from a finite spheroid of arbitrary orientation and aspect ratio that are exact in an infinite elastic medium and approximate in a half-space. The approximation, like those for other cavity shapes, becomes increasingly accurate as the depth to source ratio grows larger, and is accurate to within a few percent in most real-world cases. I have also derived expressions for the deformation-gradient tensor, i.e., the derivatives of each component of displacement with respect to each coordinate direction. These can be transformed easily into the strain and stress tensors. The expressions give deformation both at the surface and at any point within the half-space, and include conditional statements that account for limiting cases that would otherwise prove singular. I have developed MATLAB code for these expressions (and their derivatives), which I use to demonstrate the accuracy of the approximation by showing how well the uniform-pressure-change boundary condition is satisfied in a variety of cases. I also show that a vertical, oblate spheroid with a zero-length vertical axis is equivalent to the penny-shaped crack of Fialko [2001] in an infinite medium and an excellent approximation in a half-space. Finally, because, in many cases, volume change is more tangible than pressure change, I have

  9. Ultrasonic wave propagation on an inclined solid half-space partially immersed in a liquid

    Science.gov (United States)

    Dao, Cac Minh

    The interaction between a bounded ultrasonic beam and a liquid wedge over a solid half-space is studied theoretically as well as experimentally. A semi-analytical technique called Distributed Point Source Method (DPSM) is adopted for modeling the ultrasonic field in a wedge-shaped fluid structure on a solid half-space. This study is important for analyzing and understanding the propagation of ultrasonic waves used for underwater communications and inspections. A better understanding of the elastic wave propagation in water and in submerged marine strata near the seashore requires extensive investigations of such problem geometries. The semi-analytical technique used in this dissertation considers a bounded acoustic beam striking a fluid-solid interface between a fluid wedge and a solid half-space. Solution of this problem is beyond the scope of the currently available analytical methods when the beam is bounded. However, it is important to model the bounded beams because, in all underwater communications and inspections, bounded beams are used. Currently, only numerical method [Boundary Element Method (BEM) or Finite Element Method (FEM)] based packages (e.g., PZFlex) are in principle capable of modeling ultrasonic fields in such structures. However, these packages are not very accurate and are very CPU-intensive for high-frequency ultrasonic problems. At high frequencies, FEM- and BEM-based packages require huge amount of computation memory and time for their executions that the DPSM technique can avoid. The effect of the angle variation between the fluid-solid interface and the fluid wedge on the wave propagation characteristics is studied and presented.

  10. Reflection of Plane Waves in Generalized Thermoelastic Half Space under the Action of Uniform Magnetic Field

    Directory of Open Access Journals (Sweden)

    Narottam Maity

    2016-01-01

    Full Text Available Reflection of longitudinal displacement waves in a generalized thermoelastic half space under the action of uniform magnetic field has been investigated. The magnetic field is applied in such a direction that the problem can be considered as a two-dimensional one. The discussion is based on the three theories of generalized thermoelasticity: Lord-Shulman (L-S, Green-Lindsay (G-L, and Green-Naghdi (G-N with energy dissipation. We compute the possible wave velocities for different models. Amplitude ratios have been presented. The effects of magnetic field on various subjects of interest are discussed and shown graphically.

  11. Krein signatures of transfer operators for half-space topological insulators

    Science.gov (United States)

    Schulz-Baldes, Hermann; Villegas-Blas, Carlos

    2016-10-01

    We propose a complementary point of view on the topological invariants of two-dimensional tight-binding models restricted to half-spaces. The transfer operators for such systems are J-unitary on a infinite dimensional Krein space ({ K },J) and, for energies in the bulk gap, only have discrete spectrum on the unit circle. These eigenvalues have Krein inertia which can be used to define topological invariants determining the nature of the surface modes and allowing to distinguish different topological phases. This is illustrated by numerical results.

  12. Green's function for a prestressed thermoelastic half-space with an inhomogeneous coating

    Science.gov (United States)

    Belyankova, T. I.; Kalinchuk, V. V.

    2016-09-01

    A mathematical model is developed for an inhomogeneous thermoelastic prestressed half-space consisting of a stack of homogeneous or functionally graded layers rigidly attached to a homogeneous base. Each component of the inhomogeneous medium is subjected to initial mechanical stresses and temperature. Successive linearization of the constitutive relations of the nonlinear mechanics of a thermoelastic medium is performed using the theory of superposition of small deformations on finite deformations with the inhomogeneity of the medium taken into account. Integral formulas are derived to explore dynamic processes in inhomogeneous prestressed thermoelastic media.

  13. Asymptotic Behavior for a Class of Modified α-Potentials in a Half Space

    Directory of Open Access Journals (Sweden)

    Lei Qiao

    2010-01-01

    Full Text Available A class of α-potentials represented as the sum of modified Green potential and modified Poisson integral are proved to have the growth estimates Rα,l,l(x=o(xnβ|x|l−2β+2h(|x|−1 at infinity in the upper-half space of the n-dimensional Euclidean space, where the function h(|x| is a positive non-decreasing function on the interval (0,∞ satisfying certain conditions. This result generalizes the growth properties of analytic functions, harmonic functions, and superharmonic functions.

  14. Electromagnetic plane-wave pulse transmission into a Lorentz half-space.

    Science.gov (United States)

    Cartwright, Natalie A

    2011-12-01

    The propagation of an electromagnetic plane-wave signal obliquely incident upon a Lorentz half-space is studied analytically. Time-domain asymptotic expressions that increase in accuracy with propagation distance are derived by application of uniform saddle point methods on the Fourier-Laplace integral representation of the transmitted field. The results are shown to be continuous in time and comparable with numerical calculations of the field. Arrival times and angles of refraction are given for prominent transient pulse features and the steady-state signal.

  15. Reflection of plane waves in an initially stressed perfectly conducting transversely isotropic solid half-space

    Indian Academy of Sciences (India)

    Baljeet Singh; Anand Kumar Yadav

    2013-08-01

    Reflection of plane waves is studied at a free surface of a perfectly conducting transversely isotropic elastic solid half-space with initial stress. The governing equations are solved to obtain the velocity equation which indicates the existence of two quasi planar waves in the medium. Reflection coefficients and energy ratios for reflected qP and qSV waves are derived and computed numerically for a particular material. Effects of the initial stress and magnetic field are shown graphically on these reflection coefficients and energy ratios.

  16. Asymmetric Vibrations of a Circular Elastic Plate on an Elastic Half Space

    DEFF Research Database (Denmark)

    Schmidt, H.; Krenk, Steen

    1982-01-01

    The asymmetric problem of a vibrating circular elastic plate in frictionless contact with an elastic half space is solved by an integral equation method, where the contact stress appears as the unknown function. By a trigonometric expansion, the problem is reduced to a number of uncoupled two-dim...... of the vibration frequency of various plate stiffnesses and the normal component of the surface displacement field for simple excitation of the plate and passage of a plane Rayleigh wave.......The asymmetric problem of a vibrating circular elastic plate in frictionless contact with an elastic half space is solved by an integral equation method, where the contact stress appears as the unknown function. By a trigonometric expansion, the problem is reduced to a number of uncoupled two......-dimensional problems. The radial variations of contact stresses and surface displacements are represented by polynomials, the coefficients of which are directly related by an infinite matrix that is a function of the vibration frequency. The results include a parametric study of the power input as a function...

  17. The Effect of Magnetic Field and Initial Stress on Fractional Order Generalized Thermoelastic Half-Space

    Directory of Open Access Journals (Sweden)

    Sunita Deswal

    2013-01-01

    Full Text Available The aim of this paper is to study magneto-thermoelastic interactions in an initially stressed isotropic homogeneous half-space in the context of fractional order theory of generalized thermoelasticity. State space formulation with the Laplace transform technique is used to obtain the general solution, and the resulting formulation is applied to the ramp type increase in thermal load and zero stress. Solutions of the problem in the physical domain are obtained by using a numerical method of the Laplace inverse transform based on the Fourier expansion technique, and the expressions for the displacement, temperature, and stress inside the half-space are obtained. Numerical computations are carried out for a particular material for illustrating the results. Results obtained for the field variables are displayed graphically. Some comparisons have been shown in figures to present the effect of fractional parameter, ramp parameter, magnetic field, and initial stress on the field variables. Some particular cases of special interest have been deduced from the present investigation.

  18. On van der Waals friction between half-spaces at low temperature.

    Science.gov (United States)

    Barton, Gabriel

    2011-09-07

    We determine, in the van der Waals regime (neglecting retardation and relativistic effects), the frictional power loss P and the drag force F = P/u per unit area between two Drude-modelled half-spaces, with surface plasmon frequency ω(S) and realistically weak dissipation, separated by a gap of width ζ, and constrained to uniform parallel motion with relative speed u. The calculation uses only textbook-level adiabatic and perturbative methods of nonrelativistic quantum mechanics. The initial temperature is taken to be low, with τ ≡ k(B)T/ħω(S) 1. But at fixed nonzero τ, as v rises from zero, P is at first dominated by a temperature-dependent component proportional to u(2)T(2)/ζ(4). The assumptions of the model as regards the half-spaces are satisfied by most quantum-electrodynamics-based approaches, whose results in the nonretarded limit should therefore be the same as ours. We also find that the frequency distribution of the friction-induced energy increments is not thermal, suggesting that in this respect the Huttner-Barnett theory (which we use to describe dissipative materials) needs further refinement.

  19. On Waves in a Linear Elastic Half-Space with Free Boundary

    Science.gov (United States)

    Rushchitsky, J. J.

    2016-11-01

    The problem of linear elasticity for free harmonic (periodic) and solitary bell-shaped (nonperiodic) waves in an isotropic half-space with stress-free plane boundary is considered. The half-space is made of either conventional (classical structural) or nonconventional (nonclassical auxetic) material. Two cases of wave damping are studied: rapid (surface wave) and periodic (nonsurface wave). The following conclusions on a free harmonic wave are drawn: a surface wave exists in materials of both classes, but the ratio of the wave velocity to the velocity of a transverse plane wave in auxetic materials is somewhat lower than in conventional materials; a nonsurface wave cannot be described by the approach applied to conventional materials, but can theoretically exist in auxetic materials where there are two wave velocities. For a solitary (bell-shaped) wave, the assumption that the wave velocity depends on the wave phase is substantiated and some constraint is imposed on the time of travel of the wave and the way the wave velocity varies with time. The following conclusions are drawn: a rapidly damped bell-shaped wave cannot be described by the approach for both classes of materials, whereas a periodically damped bell-shaped wave can be described

  20. Trident MGT302 full course (All case and SLP)

    OpenAIRE

    Laynebaril1

    2017-01-01

     Trident MGT302 full course (All case and SLP) Click Link Below To Buy: http://hwcampus.com/shop/mgt302-full-course/   Module 1 - Case INDIVIDUAL DIFFERENCES IN THE WORKPLACE Assignment Overview Strong cognitive abilities are usually considered a very important and positive trait to seek when hiring new employees. However, one police department decided not to higher those who scored too high on a cognitive skills exam on the grounds that people who are too intellig...

  1. Effect of two nonfumigant nematicides on corn grown in two adjacent fields infested with different nematodes.

    Science.gov (United States)

    Dickson, D W; Hewlett, T E

    1987-10-01

    The organo-phosphate experimental nematicide, O-ethyl S,S-di-sec-butyl phosphorodithioate (FMC 67825), provided yield increases of corn comparable to carbofuran. Both the emulsifiable concentrate and granular formulations of FMC 67825 were equally effective. The evaluations, duplicated in two adjacent fields, clearly demonstrated the importance of the type of plant pathogenic nematodes infesting the sites. Where Belonolaimus longicaudatus occurred, yield increases ranged from 73% to 80%, whereas in the adjacent field (without B. longicaudatus) yields increases ranged from - 14% to 28%.

  2. Thermal effect on gravity waves in a compressible liquid layer over a solid half-space under initial hydrostatic stress

    Indian Academy of Sciences (India)

    Sushil Kumar Addy; Nil Ratan Chakraborty

    2005-02-01

    This paper deals with the effect of temperature on gravity waves in a compressible liquid layer over a solid half-space. It has been assumed that the liquid layer is under the action of gravity, while the solid half-space is under the influence of initial compressive hydrostatic stress. When the temperature of the half-space is altered, gravity waves propagate through the liquid layer along with sub-oceanic Rayleigh waves in the system. A new frequency equation has been derived here for gravity waves and sub-oceanic Rayleigh waves. It has been shown graphically that the phase velocity of gravity waves is influenced significantly by the initial compressive hydrostatic stress present in the solid half-space, for a particular value of the phase velocity of sub-oceanic Rayleigh waves and different coupling co-efficients of the temperature.

  3. Transient Response of Thin Wire above a Layered Half-Space Using TDIE/FDTD Hybrid Method

    Directory of Open Access Journals (Sweden)

    Bing Wei

    2012-01-01

    Full Text Available The TDIE/FDTD hybrid method is applied to calculate the transient responses of thin wire above a lossy layered half-space. The time-domain reflection of the layered half space is computed by one-dimensional modified FDTD method. Then, transient response of thin wire induced by two excitation sources (the incident wave and reflected wave is calculated by TDIE method. Finally numerical results are given to illustrate the feasibility and high efficiency of the presented scheme.

  4. The axisymmetric torsional contact problem of a functionally graded piezoelectric coated half-space

    Science.gov (United States)

    Su, Jie; Ke, Liao-Liang; Wang, Yue-Sheng; Xiang, Yang

    2017-01-01

    In this article, we study the axisymmetric torsional contact problem of a half-space coated with functionally graded piezoelectric material (FGPM) and subjected to a rigid circular punch. It is found that, along the thickness direction, the electromechanical properties of FGPMs change exponentially. We apply the Hankel integral transform technique and reduce the problem to a singular integral equation, and then numerically determine the unknown contact stress and electric displacement at the contact surface. The results show that the surface contact stress, surface azimuthal displacement, surface electric displacement, and inner electromechanical field are obviously dependent on the gradient index of the FGPM coating. It is found that we can adjust the gradient index of the FGPM coating to modify the distributions of the electric displacement and contact stress.

  5. Reflection of and SV waves at the free surface of a monoclinic elastic half-space

    Indian Academy of Sciences (India)

    Sarva Jit Singh; Sandhya Khurana

    2002-12-01

    The propagation of plane waves in an anisotropic elastic medium possessing monoclinic symmetry is discussed. The expressions for the phase velocity of qP and qSV waves propagating in the plane of elastic symmetry are obtained in terms of the direction cosines of the propagation vector. It is shown that, in general, qP waves are not longitudinal and qSV waves are not transverse. Pure longitudinal and pure transverse waves can propagate only in certain specific directions. Closed-form expressions for the reflection coefficients of qP and qSV waves incident at the free surface of a homogeneous monoclinic elastic half-space are obtained. These expressions are used for studying numerically the variation of the reflection coefficients with the angle of incidence. The present analysis corrects some fundamental errors appearing in recent papers on the subject.

  6. Inverse acoustic scattering problem in half-space with anisotropic random impedance

    Science.gov (United States)

    Helin, Tapio; Lassas, Matti; Päivärinta, Lassi

    2017-02-01

    We study an inverse acoustic scattering problem in half-space with a probabilistic impedance boundary value condition. The Robin coefficient (surface impedance) is assumed to be a Gaussian random function with a pseudodifferential operator describing the covariance. We measure the amplitude of the backscattered field averaged over the frequency band and assume that the data is generated by a single realization of λ. Our main result is to show that under certain conditions the principal symbol of the covariance operator of λ is uniquely determined. Most importantly, no approximations are needed and we can solve the full non-linear inverse problem. We concentrate on anisotropic models for the principal symbol, which leads to the analysis of a novel anisotropic spherical Radon transform and its invertibility.

  7. Indentation of a compressible soft electroactive half-space: Some theoretical aspects

    Institute of Scientific and Technical Information of China (English)

    Wen-Liang Zhang; Jin Qian; Wei-Qiu Chen

    2012-01-01

    We theoretically study the indentation response of a compressible soft electroactive material by a rigid punch.The half-space material is assumed to be initially subjected to a finite deformation and an electric biasing field. By adopting the linearized theory for incremental fields,which is established on the basis of a general nonlinear theory for electroelasticity,the appropriate equations governing the perturbed infinitesimal elastic and electric fields are derived particularly when the material is subjected to a uniform equibiaxial stretch and a uniform electric displacement.A general solution to the governing equations is presented,which is concisely expressed in terms of four quasi-harmonic functions.By adopting the potential theory method,exact contact solutions for three common perfectly conducting rigid indenters of fiat-ended circular,conical and spherical geometries can be derived,and some explicit relations that are of practical importance are outlined.

  8. Novel method for removal of multichannel impulse noise based on half-space deepest location

    Science.gov (United States)

    Baljozović, Djordje; Kovačević, Branko; Baljozović, Aleksandra

    2012-01-01

    A novel method is proposed for removing impulse (random-valued and salt-and-pepper) noise from multichannel digital images based on an adapted version of the DEEPLOC algorithm introduced by A. Struyf and P. J. Rousseeuw for calculation of approximate half-space (Tukey's) deepest location (median) in multivariate case. Due to its intrinsic multivariate/multidimensional nature, the proposed method eliminates the noise simultaneously on all channels without their separation, which preserves the spectral correlation between channels in a multichannel image. Denoising results of this new nonlinear spatial domain filter applied to benchmark images outperform currently used state-of-the-art filters for impulse noise removal from multichannel images in terms of both objective effectiveness criteria [peak-signal-to-noise-ratio (PSNR), mean absolute error (MAE), and normalized color distance (NCD)] and visual quality. The proposed filter successfully preserves the edges and fine image details, and is very effective for removal of medium and heavy multichannel impulse noise.

  9. Wave Propagation in a Micropolar Transversely Isotropic Generalized Thermoelastic Half-Space

    Directory of Open Access Journals (Sweden)

    Gupta R.R.

    2014-05-01

    Full Text Available Rayleigh waves in a half-space exhibiting microplar transversely isotropic generalized thermoelastic properties based on the Lord-Shulman (L-S, Green and Lindsay (G-L and Coupled thermoelasticty (C-T theories are discussed. The phase velocity and attenuation coefficient in the previous three different theories have been obtained. A comparison is carried out of the phase velocity, attenuation coefficient and specific loss as calculated from the different theories of generalized thermoelasticity along with the comparison of anisotropy. The amplitudes of displacements, microrotation, stresses and temperature distribution were also obtained. The results obtained and the conclusions drawn are discussed numerically and illustrated graphically. Relevant results of previous investigations are deduced as special cases.

  10. Numerical modelling of complex resistivity effects on a homogeneous half-space at low frequencies

    DEFF Research Database (Denmark)

    Ingeman-Nielsen, Thomas; Baumgartner, François

    2006-01-01

    half-space with CR effects and study some aspects of the complex coupling function. We advocate the use of the CR based coupling function in the interpretation process, in order to obtain a better understanding of the physical processes involved in CR effects. Application of the model to real field......The many different existing models describing the spectral behavior of the resistivity of geological materials at low frequency, combined with the lack of available field data, render the interpretation of complex resistivity (CR) data very difficult. With a recent interest in CR measurements...... for environmental applications and thanks to technological progress, the use of wide band frequency equipment seems promising, and it is expected to shed light on the different results among the published solutions to the electromagnetic (EM) coupling problem. We review the theory of EM coupling over a homogeneous...

  11. Surface instability of a homogeneous half-space coupled with finite number of laminas

    Energy Technology Data Exchange (ETDEWEB)

    Chekhov, V.N.; Stukotilov, V.S.

    1995-09-10

    In the context of the model of a piecewise-homogeneous medium in three-dimensional formulation we study the problem of the surface loss of stability in laminated semi-bounded media with a finite number of laminas. For the study we invoke a version of three-dimensional stability theory constructed for small pre-critical deformations when the pre-critical state is determined from the geometrically linear theory. To construct the resolvent characteristic equations we use the matrix representation of the basic relations. Using a computer we carry out a numerical study of the stability of a homogeneous half-space coupled to various numbers of laminas, and we conduct a comparative analysis of the results.

  12. Reflection and transmission of full-vector X-waves normally incident on dielectric half spaces

    KAUST Repository

    Salem, Mohamed

    2011-08-01

    The reflection and transmission of full-vector X-Waves incident normally on a planar interface between two lossless dielectric half-spaces are investigated. Full-vector X-Waves are obtained by superimposing transverse electric and magnetic polarization components, which are derived from the scalar X-Wave solution. The analysis of transmission and reflection is carried out via a straightforward but yet effective method: First, the X-Wave is decomposed into vector Bessel beams via the Bessel-Fourier transform. Then, the reflection and transmission coefficients of the beams are obtained in the spectral domain. Finally, the transmitted and reflected X-Waves are obtained via the inverse Bessel-Fourier transform carried out on the X-wave spectrum weighted with the corresponding coefficient. © 2011 IEEE.

  13. Love waves propagation in a transversely isotropic piezoelectric layer on a piezomagnetic half-space.

    Science.gov (United States)

    Ezzin, Hamdi; Ben Amor, Morched; Ben Ghozlen, Mohamed Hédi

    2016-07-01

    A theoretical approach is taken into consideration to investigate Love wave propagation in a transversely isotropic piezoelectric layer on a piezomagnetic half-space. The magneto-electrically open and short conditions are applied to solve the problem. The phase and group velocity of the Love wave is numerically calculated for the magneto-electrically open and short cases, respectively. The variations of magneto-electromechanical coupling factor, mechanical displacements, electric and magnetic potentials along the thickness direction of the layers are obtained and discussed. The numerical results clearly show the influence of different stacking sequences on dispersion curves and on magneto-electromechanical coupling factor. This work may be relevant to analysis and design of various acoustic surface wave devices constructed from piezoelectric and piezomagnetic materials.

  14. THERMAL CONSOLIDATION OF LAYERED POROUS HALF-SPACE TO VARIABLE THERMAL LOADING

    Institute of Scientific and Technical Information of China (English)

    BAI Bing

    2006-01-01

    An analytical method was derived for the thermal consolidation of layered,saturated porous half-space to variable thermal loading with time. In the coupled governing equations of linear thermoelastic media, the influences of thermo-osmosis effect and thermal filtration effect were introduced. Solutions in Laplace transform space were first obtained and then numerically inverted. The responses of a double-layered porous space subjected to exponential decaying thermal loading were studied. The influences of the differences between the properties of the two layers (e.g., the coefficient of thermal consolidation, elastic modulus) on thermal consolidation were discussed. The studies show that the coupling effects of displacement and stress fields on temperature field can be completely neglected, however, thc thermo-osmosis effect has an obvious influence on thermal responses.

  15. fMRI Evidence of Acupoints Specificity in Two Adjacent Acupoints

    Directory of Open Access Journals (Sweden)

    Hua Liu

    2013-01-01

    Full Text Available Objectives. Acupoint specificity is the foundation of acupuncture treatment. The aim of this study is to investigate whether the acupoint specificity exists in two adjacent acupoints. Design and Setting. Two adjacent real acupoints, LR3 (Taichong and ST44 (Neiting, and a nearby nonacupoint were selected. Thirty-three health volunteers were divided into three groups in random order, and each group only received acupuncture at one of the three points. While they received acupuncture, fMRI scan was performed. Results. The common cerebral activated areas responding to LR3 and ST44 included the contralateral primary somatosensory area (SI and ipsilateral cerebellum. Acupuncture at LR3 specifically activated contralateral middle occipital gyrus, ipsilateral medial frontal gyrus, superior parietal lobe, middle temporal gyrus, rostral anterior cingulate cortex (rACC, lentiform nucleus, insula, and contralateral thalamus. Stimulation at ST44 selectively activated ipsilateral secondary somatosensory area (SII, contralateral middle frontal gyrus, inferior frontal gyrus, lingual gyrus, lentiform nucleus, and bilateral posterior cingulate cortex (PCC. Conclusions. Acupuncture at adjacent acupoints elicits distinct cerebral activation patterns, and those specific patterns might be involved in the mechanism of the specific therapeutic effects of different acupoints.

  16. Broadband strong motion simulation in layered half-space using stochastic Green's function technique

    Science.gov (United States)

    Hisada, Y.

    2008-04-01

    The stochastic Green’s function method, which simulates one component of the far-field S-waves from an extended fault plane at high frequencies (Kamae et al., J Struct Constr Eng Trans AIJ, 430:1 9, 1991), is extended to simulate the three components of the full waveform in layered half-spaces for broadband frequency range. The method firstly computes ground motions from small earthquakes, which correspond to the ruptures of sub-faults on a fault plane of a large earthquake, and secondly constructs the strong motions of the large earthquake by superposing the small ground motions using the empirical Green’s function technique (e.g., Irikura, Proc 7th Japan Earthq Eng Symp, 151 156, 1986). The broadband stochastic omega-square model is proposed as the moment rate functions of the small earthquakes, in which random and zero phases are used at higher and lower frequencies, respectively. The zero phases are introduced to simulate a smooth ramp function of the moment function with the duration of 1/fc s (fc: the corner frequency) and to reproduce coherent strong motions at low frequencies (i.e., the directivity pulse). As for the radiation coefficients, the theoretical values of double couple sources for lower frequencies and the theoretical isotropic values for the P-, SV-, and SH-waves (Onishi and Horike, J Struct Constr Eng Trans AIJ, 586:37 44, 2004) for high frequencies are used. The proposed method uses the theoretical Green’s functions of layered half-spaces instead of the far-field S-waves, which reproduce the complete waves including the direct and reflected P- and S-waves and surface waves at broadband frequencies. Finally, the proposed method is applied to the 1994 Northridge earthquake, and results show excellent agreement with the observation records at broadband frequencies. At the same time, the method still needs improvements especially because it underestimates the high-frequency vertical components in the near fault range. Nonetheless, the method

  17. Vertical dipole above a dielectric or metallic half-space - energy flow considerations

    CERN Document Server

    Berman, P R; Khitrova, G

    2014-01-01

    The emission pattern from a classical dipole located above and oriented perpendicular to a metallic or dielectric half space is calculated for a dipole driven at constant amplitude. This is a problem considered originally by Sommerfeld and analyzed subsequently by numerous authors. In contrast to most previous treatments, however, we focus on the energy flow in the metal or dielectric. It is shown that the radial Poynting vector in the metal points inwards when the frequency of the dipole is below the surface plasmon resonance frequency. In this case, energy actually flows of the interface at small radii. The Joule heating in the metal is also calculated and it is shown explicitly that Poynting's theorem holds for a cylindrical surface in the metal. When the metal is replaced by a dielectric having permittivity less than that of the medium in which the dipole is immersed, it is found that energy flows out of the interface for sufficiently large radii. In all cases it is assumed that the imaginary part of the ...

  18. DYNAMIC BEHAVIOR OF TWO COLLINEAR PERMEABLE CRACKS IN A PIEZOELECTRIC LAYER BONDED TO TWO HALF SPACES

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    The dynamic behavior of two collinear cracks in a piezoelectric layer bonded to two half spaces under harmonic anti-plane shear waves was investigated by means of Schmidt method. The cracks are vertically to the interfaces of the piezoelectric layer.The boundary conditions of the electrical field were assumed to be the permeable crack surface. By using the Fourier transform, the problem can be solved with the help of two pairs of triple integral equations. Numerical examples were presented to show the effect of the geometry of the interacting cracks, the piezoelectric constants of the materials and the frequency of the incident waves upon the stress intensity factors. The results show that the dynamic field will impede or enhance the propagation of the crack in a piezoelectric material at different stages of the frequency of the incident waves. It is found that the electric displacement intensity factors for the permeable crack surface conditions are much smaller than that for the impermeable crack surface conditions.

  19. Wave energy transfer in elastic half-spaces with soft interlayers.

    Science.gov (United States)

    Glushkov, Evgeny; Glushkova, Natalia; Fomenko, Sergey

    2015-04-01

    The paper deals with guided waves generated by a surface load in a coated elastic half-space. The analysis is based on the explicit integral and asymptotic expressions derived in terms of Green's matrix and given loads for both laminate and functionally graded substrates. To perform the energy analysis, explicit expressions for the time-averaged amount of energy transferred in the time-harmonic wave field by every excited guided or body wave through horizontal planes and lateral cylindrical surfaces have been also derived. The study is focused on the peculiarities of wave energy transmission in substrates with soft interlayers that serve as internal channels for the excited guided waves. The notable features of the source energy partitioning in such media are the domination of a single emerging mode in each consecutive frequency subrange and the appearance of reverse energy fluxes at certain frequencies. These effects as well as modal and spatial distribution of the wave energy coming from the source into the substructure are numerically analyzed and discussed.

  20. Half-space problem of unsteady evaporation and condensation of polyatomic gas

    Science.gov (United States)

    Inaba, Masashi; Yano, Takeru

    2016-11-01

    On the basis of polyatomic version of the ellipsoidal-statistical Bhatnager-Gross-Krook (ES-BGK) model, we consider time-periodic gas flows in a semi-infinite expanse of an initially equilibrium polyatomic gas (methanol) bounded by its planar condensed phase. The kinetic boundary condition at the vapor-liquid interface is assumed to be the complete condensation condition with periodically time-varying macroscopic variables (temperature, saturated vapor density and velocity of the interface), and the boundary condition at infinity is the local equilibrium distribution function. The time scale of variation of macroscopic variables is assumed to be much larger than the mean free time of gas molecules, and the variations of those from a reference state are assumed to be sufficiently small. We numerically investigate thus formulated time-dependent half-space problem for the polyatomic version of linearized ES-BGK model equation with the finite difference method for the case of the Strouhal number Sh=0.01 and 0.1. It is shown that the amplitude of the mass flux at the interface is the maximum, and the phase difference in time between the mass flux and v∞ - vℓ (v∞: vapor velocity at infinity, vℓ: velocity of the vapor-liquid interface) is the minimum absolute value, when the phase difference in time between the liquid surface temperature (the saturated vapor density) and the velocity of interface is close to zero.

  1. Scattering of SH-wave by multiple circular cavities in half space

    Institute of Scientific and Technical Information of China (English)

    王国庆; 刘殿魁

    2002-01-01

    In this paper, an analytic method is developed to address steady SH-wave scattering and perform dynamic analysisof multiple circular cavities in half space. The scattered wave function used for scattering of SH-waves by multiple circularcavities, which automatically satisfies the stress-free condition at the horizontal surface, is constructed by applying thesymmetry of the SH-wave scattering and the method of multi-polar coordinates system. Applying this scattered wave functionand method of moving coordinates, the original problem can be transformed to the problem of SH-wave scattering by multiplecircular cavities in the full space. Finally, the solution of the problem can be reduced to a series of algebraic equations andsolved numerically by truncating the infinite algebraic equations to the finite ones. Numerical examples are provided for casewith two cavities to show the effect of wave number, and the distances between the centers of the cavities and from the centersto the ground surface on the dynamic stress concentration around the cavity impacted by incident steady SH-wave.

  2. An Analytical Study on Distribution of Statically Determinate Stresses in Particulate Half Space

    Institute of Scientific and Technical Information of China (English)

    Wu Bingkun

    1996-01-01

    General solution of stresses solved from the two-dimensiona I system of equilibrium equations in Cartesian coordinates is characterized by the presence of two families of characteristic lines along which initial stresses and discontinuities in them are transmitted intact far down to infinity. This is against our intuition and not verifiable by experimental findings.For the fundamental case of infinite uniform pressure on the upper surface, a comparison between solutions from equilibrium equations in Cartesian coordinates and from those in polar coordinates is carried out in details. The semi-infinite characteristic lines in the former are bent up to exponential spirals with both ends on the upper surface in the latter. Thus,the transmission pattern from solution in polar coordinates comes closer to actual situation. However, in polar reference frame, the solution for distribution of stresses in particulate half space under surface strip pressure or so can then only be obtained from boundary value problem of second order partial differential equation.

  3. Modular Hamiltonians for Deformed Half-Spaces and the Averaged Null Energy Condition

    CERN Document Server

    Faulkner, Thomas; Parrikar, Onkar; Wang, Huajia

    2016-01-01

    We study modular Hamiltonians corresponding to the vacuum state for deformed half-spaces in relativistic quantum field theories on $\\mathbb{R}^{1,d-1}$. We show that in addition to the usual boost generator, there is a contribution to the modular Hamiltonian at first order in the shape deformation, proportional to the integral of the null components of the stress tensor along the Rindler horizon. We use this fact along with monotonicity of relative entropy to prove the averaged null energy condition in Minkowski space-time. This subsequently gives a new proof of the Hofman-Maldacena bounds on the parameters appearing in CFT three-point functions. Our main technical advance involves adapting newly developed perturbative methods for calculating entanglement entropy to the problem at hand. These methods were recently used to prove certain results on the shape dependence of entanglement in CFTs and here we generalize these results to excited states and real time dynamics. We also discuss the AdS/CFT counterpart o...

  4. Modular Hamiltonians for deformed half-spaces and the averaged null energy condition

    Science.gov (United States)

    Faulkner, Thomas; Leigh, Robert G.; Parrikar, Onkar; Wang, Huajia

    2016-09-01

    We study modular Hamiltonians corresponding to the vacuum state for deformed half-spaces in relativistic quantum field theories on {{R}}^{1,d-1} . We show that in addition to the usual boost generator, there is a contribution to the modular Hamiltonian at first order in the shape deformation, proportional to the integral of the null components of the stress tensor along the Rindler horizon. We use this fact along with monotonicity of relative entropy to prove the averaged null energy condition in Minkowski space-time. This subsequently gives a new proof of the Hofman-Maldacena bounds on the parameters appearing in CFT three-point functions. Our main technical advance involves adapting newly developed perturbative methods for calculating entanglement entropy to the problem at hand. These methods were recently used to prove certain results on the shape dependence of entanglement in CFTs and here we generalize these results to excited states and real time dynamics. We also discuss the AdS/CFT counterpart of this result, making connection with the recently proposed gravitational dual for modular Hamiltonians in holographic theories.

  5. From RLP to SLP: Two Different Approaches to Landscape Planning

    Directory of Open Access Journals (Sweden)

    Federica Isola

    2014-05-01

    Full Text Available The concepts of governance and sustainable development are concepts related to complex systems and processes, in terms of problems and implications, with a variety of people involved in different ways and whose number has increased over time. In the processes of regional governance, the concept of sustainability interacts with the environment and to the territory. Since 2006, year of approval of its Regional Landscape Plan (RLP, the Region of Sardinia, has been experiencing a new era of regional governance characterisedcharacterized by a new understanding of environmental resources; and by a different relational approach among regional government bodies, as well as between them and local communities. In 2009 began the revision phase of the plan recently concluded with the approval of the Sardinia Landscape Plan (SLP. This paper will highlight a comparison between RLP and SLP focusing on three aspects: i the concept of protection and safeguarding of the territory; ii the institutional governance; iii the application of the Strategic Environmental Assessment.

  6. Diffraction of plane P waves by a canyon of arbitrary shape in poroelastic half-space (Ⅰ): Formulation

    Institute of Scientific and Technical Information of China (English)

    Jianwen Liang; Zhongxian Liu

    2009-01-01

    This paper presents an indirect boundary integration equation method for diffraction of plane P waves by a two-dimensional canyon of arbitrary shape in poroelastic half-space. The Green's functions of compressional and shear wave sources in poroelastic half-space are derived based on Biot's theory. The scattered waves are constructed using the fictitious wave sources close to the boundary of the canyon, and magnitude of the fictitious wave sources are determined by the boundary conditions. The precision of the method is verified by the satisfaction extent of boundary conditions, the comparison between the degenerated solutions of single-phased half-space and the well-known solutions, and the numerical stability of the method.

  7. Computation of a combined spherical-elastic and viscous-half-space earth model for ice sheet simulation

    CERN Document Server

    Bueler, E; Kallen-Brown, J A; Bueler, Ed; Lingle, Craig S.; Kallen-Brown, Jed A.

    2006-01-01

    This report starts by describing the continuum model used by Lingle & Clark (1985) to approximate the deformation of the earth under changing ice sheet and ocean loads. That source considers a single ice stream, but we apply their underlying model to continent-scale ice sheet simulation. Their model combines Farrell's (1972) elastic spherical earth with a viscous half-space overlain by an elastic plate lithosphere. The latter half-space model is derivable from calculations by Cathles (1975). For the elastic spherical earth we use Farrell's tabulated Green's function, as do Lingle & Clark. For the half-space model, however, we propose and implement a significantly faster numerical strategy, a spectral collocation method (Trefethen 2000) based directly on the Fast Fourier Transform. To verify this method we compare to an integral formula for a disc load. To compare earth models we build an accumulation history from a growing similarity solution from (Bueler, et al.~2005) and and simulate the coupled (ic...

  8. Estimation of elastic moduli in a compressible Gibson half-space by inverting Rayleigh-wave phase velocity

    Science.gov (United States)

    Xia, J.; Xu, Y.; Miller, R.D.; Chen, C.

    2006-01-01

    A Gibson half-space model (a non-layered Earth model) has the shear modulus varying linearly with depth in an inhomogeneous elastic half-space. In a half-space of sedimentary granular soil under a geostatic state of initial stress, the density and the Poisson's ratio do not vary considerably with depth. In such an Earth body, the dynamic shear modulus is the parameter that mainly affects the dispersion of propagating waves. We have estimated shear-wave velocities in the compressible Gibson half-space by inverting Rayleigh-wave phase velocities. An analytical dispersion law of Rayleigh-type waves in a compressible Gibson half-space is given in an algebraic form, which makes our inversion process extremely simple and fast. The convergence of the weighted damping solution is guaranteed through selection of the damping factor using the Levenberg-Marquardt method. Calculation efficiency is achieved by reconstructing a weighted damping solution using singular value decomposition techniques. The main advantage of this algorithm is that only three parameters define the compressible Gibson half-space model. Theoretically, to determine the model by the inversion, only three Rayleigh-wave phase velocities at different frequencies are required. This is useful in practice where Rayleigh-wave energy is only developed in a limited frequency range or at certain frequencies as data acquired at manmade structures such as dams and levees. Two real examples are presented and verified by borehole S-wave velocity measurements. The results of these real examples are also compared with the results of the layered-Earth model. ?? Springer 2006.

  9. Identification of SlpB, a Cytotoxic Protease from Serratia marcescens.

    Science.gov (United States)

    Shanks, Robert M Q; Stella, Nicholas A; Hunt, Kristin M; Brothers, Kimberly M; Zhang, Liang; Thibodeau, Patrick H

    2015-07-01

    The Gram-negative bacterium and opportunistic pathogen Serratia marcescens causes ocular infections in healthy individuals. Secreted protease activity was characterized from 44 ocular clinical isolates, and a higher frequency of protease-positive strains was observed among keratitis isolates than among conjunctivitis isolates. A positive correlation between protease activity and cytotoxicity to human corneal epithelial cells in vitro was determined. Deletion of prtS in clinical keratitis isolate K904 reduced, but did not eliminate, cytotoxicity and secreted protease production. This indicated that PrtS is necessary for full cytotoxicity to ocular cells and implied the existence of another secreted protease(s) and cytotoxic factors. Bioinformatic analysis of the S. marcescens Db11 genome revealed three additional open reading frames predicted to code for serralysin-like proteases noted here as slpB, slpC, and slpD. Induced expression of prtS and slpB, but not slpC and slpD, in strain PIC3611 rendered the strain cytotoxic to a lung carcinoma cell line; however, only prtS induction was sufficient for cytotoxicity to a corneal cell line. Strain K904 with deletion of both prtS and slpB genes was defective in secreted protease activity and cytotoxicity to human cell lines. PAGE analysis suggests that SlpB is produced at lower levels than PrtS. Purified SlpB demonstrated calcium-dependent and AprI-inhibited protease activity and cytotoxicity to airway and ocular cell lines in vitro. Lastly, genetic analysis indicated that the type I secretion system gene, lipD, is required for SlpB secretion. These genetic data introduce SlpB as a new cytotoxic protease from S. marcescens.

  10. Differential energy costs of winter acclimatized common spiny mice Acomys cahirinus from two adjacent habitats.

    Science.gov (United States)

    Scantlebury, Michael; Shanas, Uri; Kupshtein, Hagai; Speakman, John R; Haim, Abraham

    2004-02-01

    The common spiny mouse Acomys cahirinus, of Ethiopian origin, has a widespread distribution across arid, semi-arid and Mediterranean parts of the Arabian sub-region. We compared the daily energy expenditure (DEE), water turnover (WTO) and sustained metabolic scope (SusMS=DEE/resting metabolic rate) of two adjacent populations during the winter. Mice were captured from North- and South- facing slopes (NFS and SFS) of the same valley, comprising mesic and xeric habitats, respectively. Both DEE and SusMS winter values were greater in NFS than SFS mice and were significantly greater than values previously measured in the summer for these two populations in the same environments. However, WTO values were consistent with previously established values and were not significantly different from allometric predictions for desert eutherians. We suggest that physiological plasticity in energy expenditure, which exists both temporally and spatially, combined with stable WTO, perhaps reflecting a xeric ancestry, has enabled A. cahirinus to invade a wide range of habitats.

  11. Hybrid male sterility in rice controlled by interaction between divergent alleles of two adjacent genes.

    Science.gov (United States)

    Long, Yunming; Zhao, Lifeng; Niu, Baixiao; Su, Jing; Wu, Hao; Chen, Yuanling; Zhang, Qunyu; Guo, Jingxin; Zhuang, Chuxiong; Mei, Mantong; Xia, Jixing; Wang, Lan; Wu, Haibin; Liu, Yao-Guang

    2008-12-01

    Sterility is common in hybrids between divergent populations, such as the indica and japonica subspecies of Asian cultivated rice (Oryza sativa). Although multiple loci for plant hybrid sterility have been identified, it remains unknown how alleles of the loci interact at the molecular level. Here we show that a locus for indica-japonica hybrid male sterility, Sa, comprises two adjacent genes, SaM and SaF, encoding a small ubiquitin-like modifier E3 ligase-like protein and an F-box protein, respectively. Most indica cultivars contain a haplotype SaM(+)SaF(+), whereas all japonica cultivars have SaM(-)SaF(-) that diverged by nucleotide variations in wild rice. Male semi-sterility in this heterozygous complex locus is caused by abortion of pollen carrying SaM(-). This allele-specific gamete elimination results from a selective interaction of SaF(+) with SaM(-), a truncated protein, but not with SaM(+) because of the presence of an inhibitory domain, although SaM(+) is required for this male sterility. Lack of any one of the three alleles in recombinant plants does not produce male sterility. We propose a two-gene/three-component interaction model for this hybrid male sterility system. The findings have implications for overcoming male sterility in inter-subspecific hybrid rice breeding.

  12. Characteristics of head wave in multi-layered half-space

    Institute of Scientific and Technical Information of China (English)

    张坚; 张海明; 陈晓非

    2002-01-01

    In this article, we analyze the dynamic characteristics of head wave in multi-layered half-space media models with high-velocity layer or low-velocity layer, and the model with a continuous transition-zone between the crust and the mantle by using synthetic seismogram. It is concluded that the dynamic characteristics of head wave are sensitive to the thickness and velocity of the high-velocity layer. There is obvious diffraction phenomenon of seismic wave if the thickness of high-velocity layer is very small compared with the characteristic wavelength. In this case, the high-velocity layer cannot shield the head wave propagating along the upper interface of the media below it, and the amplitude of this head wave is proportional to the thickness or the velocity of the high-velocity layer. When the thickness of high-velocity layer is nearly identical to the characteristic wavelength of seismic wave, the wave phases reflected from the bottom of the high-velocity layer and the head wave phase may have very close arrival and weaken each other because of destructive interference. As to low-velocity layer, the amplitude of the head wave is weak and decreases with the velocity of this layer. It is also found that if a continuous transition-zone between the crust and the mantle is introduced, we can get a strong apparent head wave phase in synthetic seismogram and the amplitude of this phase increases with the thickness or velocity gradient of the transition-zone.

  13. Differential role of SLP-76 domains in T cell development and function.

    Science.gov (United States)

    Kumar, Lalit; Pivniouk, Vadim; de la Fuente, Miguel A; Laouini, Dhafer; Geha, Raif S

    2002-01-22

    The adapter SLP-76 is essential for thymocyte development. SLP-76(-/-) mice were reconstituted with SLP-76 deletion mutant transgenes to examine the role of SLP-76 domains in T cell development and function. The N-terminal domain deletion mutant completely failed to restore thymocyte development. Mice reconstituted with Gads-binding site and SH2 domain deletion mutants had decreased thymic cellularity, impaired transition from double to single positive thymocytes, and decreased numbers of mature T cells in the spleen. Calcium mobilization and extracellular signal-regulated protein kinase activation were decreased in the Gads-binding site mutant but almost normal in the SH2 domain mutant. T cells from both mutants failed to proliferate following T cell antigen receptor ligation. Nevertheless, both mutants mounted partial cutaneous hypersensitivity responses and normal T cell dependent IgG1 antibody responses. These results indicate differential roles for SLP-76 domains in T cell development, proliferation and effector functions.

  14. Contrasting factors controlling microbial respiratory activity in the sediment of two adjacent Mediterranean wetlands.

    Science.gov (United States)

    de Vicente, Inmaculada; Amores, Victoria; Guerrero, Francisco; Cruz-Pizarro, Luis

    2010-07-01

    Electron transport system (ETS) activity of sediments as an indication of microbial metabolic activity was examined in two adjacent Mediterranean wetlands (southern Spain). We determined the spatio-temporal variation in ETS, and we explored the potential biological [organic matter (OM), chlorophyll a (Chl a), aerobic and anaerobic bacteria] drivers of sediment ETS activity. ETS activity was notably higher in the eutrophic Lake Nueva (34.91 microl O(2) g(-1) D.W. h(-1)) than in the hypertrophic Lake Honda (24.99 microl O(2) g(-1) D.W. h(-1)). Strong spatial differences were observed in ETS in both study sites. Highest ETS values were achieved at the surface sediment at the deepest sampling station in each lake and a notable reduction in ETS with sediment depth was observed. By using linear regression and multiple regression analysis, OM was identified as the best predictor of ETS in Lake Honda while Chl a was the best predictor in Lake Nueva. The strong influence of OM supply on ETS activity in sediment from Lake Honda was the consequence of the labile nature of sedimentary OM, while a more refractory OM (with a higher contribution of vascular plants) comprised most of the sedimentary OM from Lake Nueva. By contrast, a large contribution of phytobenthos (supported by a higher lake water transparency) to ETS has been recognized in sediments from Lake Nueva. In summary, the results of this study revealed that the relative importance of planktonic primary producers (phytoplankton), benthic algae and vascular plants in the study sites could explain the differences observed in the intensity of sediment ETS as well as in their drivers.

  15. Casimir force between a half-space and a plate of finite thickness

    Science.gov (United States)

    Høye, Johan S.; Brevik, Iver

    2016-05-01

    Zero-frequency Casimir theory is analyzed from different viewpoints, with the aim of obtaining further insight into the delicate Drude-plasma issue that turns up when one considers thermal corrections to the Casimir force. The problem is essentially that the plasma model, physically inferior in comparison to the Drude model since it leaves out dissipation in the material, apparently gives the best results when comparing with recent experiments. Our geometric setup is quite conventional, namely, a dielectric plate separated from a dielectric half-space by a vacuum gap, both media being made of the same material. Our investigation is divided into the following categories: (1) Making use of the statistical-mechanical method developed by J. S. Høye and I. Brevik [Physica A (Amsterdam, Neth.) 259, 165 (1998), 10.1016/S0378-4371(98)00249-0], implying that the quantized electromagnetic field is replaced by interaction between dipole moments oscillating in harmonic potentials, we first verify that the Casimir force is in agreement with the Drude prediction. No use of Fresnel's reflection coefficients is made at this stage. (2) Then turning to the field-theoretic description implying use of the reflection coefficients, we derive results in agreement with the forgoing when first setting the frequency equal to zero, before letting the permittivity become large. With the plasma relation the reflection coefficient for TE zero-frequency modes depends on the component of the wave vector parallel to the surfaces and lies between 0 and 1. This contradicts basic electrostatic theory. (3) Turning to high-permeability magnetic materials, the TE zero-frequency mode describes the static magnetic field in the same way the TM zero-frequency modes describe the static electric fields in electrostatics. With the plasma model magnetic fields, except for a small part, cannot pass through metals; that is, metals effectively become superconductors. However, recent experimental results clearly

  16. T Cell Costimulation via the Integrin VLA-4 Inhibits the Actin-Dependent Centralization of Signaling Microclusters Containing the Adaptor SLP-76

    National Research Council Canada - National Science Library

    Nguyen, Ken; Sylvain, Nicholas R; Bunnell, Stephen C

    2008-01-01

    .... Costimulatory VLA-4 ligands also prevented the centralization of SLP-76, promoted microcluster persistence, prolonged lateral interactions between SLP-76 and its upstream kinase, ZAP-70, and retained...

  17. Dynamic response of a laterally loaded fixed-head pile group in a transversely isotropic multilayered half-space

    Science.gov (United States)

    Ai, Zhi Yong; Li, Zhi Xiong; Wang, Li Hua

    2016-12-01

    The time-harmonic response of a laterally loaded fixed-head pile group embedded in a transversely isotropic multilayered half-space is investigated using a finite element and indirect boundary element coupling method. The piles are solved by the finite element method (FEM), while the soil can be modeled by the indirect boundary element method (BEM) with the aid of the fundamental solution for a transversely isotropic multilayered half-space in a cylindrical coordinate system. The governing equation of the pile-soil-pile dynamic interaction is established by applying the FEM-BEM coupling method. Numerical examples are carried out to validate the presented theory and to investigate influences of the soil's anisotropy and layering on the dynamic response of pile groups.

  18. Two-dimensional wave propagation in an elastic half-space with quadratic nonlinearity: a numerical study.

    Science.gov (United States)

    Küchler, Sebastian; Meurer, Thomas; Jacobs, Laurence J; Qu, Jianmin

    2009-03-01

    This study investigates two-dimensional wave propagation in an elastic half-space with quadratic nonlinearity. The problem is formulated as a hyperbolic system of conservation laws, which is solved numerically using a semi-discrete central scheme. These numerical results are then analyzed in the frequency domain to interpret the nonlinear effects, specifically the excitation of higher-order harmonics. To quantify and compare the nonlinearity of different materials, a new parameter is introduced, which is similar to the acoustic nonlinearity parameter beta for one-dimensional longitudinal waves. By using this new parameter, it is found that the nonlinear effects of a material depend on the point of observation in the half-space, both the angle and the distance to the excitation source. Furthermore it is illustrated that the third-order elastic constants have a linear effect on the acoustic nonlinearity of a material.

  19. A two-dimensional problem for a fibre-reinforced anisotropic thermoelastic half-space with energy dissipation

    Indian Academy of Sciences (India)

    Ibrahim A Abbas

    2011-06-01

    The theory of thermoelasticity with energy dissipation is employed to study plane waves in a fibre-reinforced anisotropic thermoelastic half-space. We apply a thermal shock on the surface of the half-space which is taken to be traction free. The problem is solved numerically using a finite element method. Moreover, the numerical solutions of the non-dimensional governing partial differential equations of the problem are shown graphically. Comparisons are made with the results predicted by Green–Naghdi theory of the two types (GNII without energy dissipation) and (GNIII with energy dissipation). We found that the reinforcement has great effect on the distribution of field quantities. Results carried out in this paper can be used to design various fibre-reinforced anisotropic thermoelastic elements under thermal load to meet special engineering requirements.

  20. Surface wave propagation in a double liquid layer over a liquid-saturated porous half-space

    Indian Academy of Sciences (India)

    Rajneesh Kumar; Aseem Miglani; N R Garg

    2002-12-01

    The frequency equation is derived for surface waves in a liquidsaturated porous half-space supporting a double layer, that of inhomogeneous and homogeneous liquids. Asymptotic approximations of Bessel functions are used for long and short wavelength cases. Certain other problems are discussed as special cases. Velocity ratio (phase and group velocity) is obtained as a function of wavenumber and the results are shown graphically.

  1. SH-Wave at a Plane Interface between Homogeneous and Inhomogeneous Fibre-Reinforced Elastic Half-Spaces

    Directory of Open Access Journals (Sweden)

    C. Zorammuana

    2015-01-01

    Full Text Available The problem of reflection and refraction of SH-waves at a plane interface between the homogeneous and inhomogeneous fibre-reinforced elastic half-spaces has been investigated. Amplitude and energy ratios corresponding to the reflected and refracted SH-waves are derived using appropriate boundary conditions. These ratios are computed numerically for a particular model and the results are depicted graphically.

  2. Half space albedo problem for the nonconservative vector equation of transfer with a combination of Rayleigh and isotropic scattering

    Science.gov (United States)

    Şenyiğit, M.

    2016-09-01

    The half-space albedo problem has been solved for a combination of Rayleigh and isotropic scattering using HN method which is developed for the neutron transport studies. The numerical results are compared with exact values obtained using variational method and Chandrasekhar's equation for the {H}-matrix. The analytical solutions of HN method are easy to handle in comparison with the other methods. The numerical results are in good agreement with previous works in literature.

  3. A 1D time-domain method for in-plane wave motions in a layered half-space

    Institute of Scientific and Technical Information of China (English)

    Jingbo Liu; Yan Wang

    2007-01-01

    A 1D finite element method in time domain is developed in this paper and applied to calculate in-plane wave motions of free field exited by SV or P wave oblique incidence in an elastic layered half-space. First, the layered half-space is discretized on the basis of the propagation cha-racteristic of elastic wave according to the Snell law. Then, the finite element method with lumped mass and the cen-tral difference method are incorporated to establish 2D wave motion equations, which can be transformed into 1D equa-tions by discretization principle and explicit finite element method. By solving the 1D equations, the displacements of nodes in any vertical line can be obtained, and the wave motions in layered half-space are finally determined based on the characteristic of traveling wave. Both the theoretical ana-lysis and the numerical results demonstrate that the proposed method has high accuracy and good stability.

  4. Propagation of surface SH waves on a nonlinear half space coated with a layer of nonuniform thickness

    Science.gov (United States)

    Deliktaş, Ekin; Teymür, Mevlüt

    2017-07-01

    In this study, the propagation of shear horizontal (SH) waves in a nonlinear elastic half space covered by a nonlinear elastic layer with a slowly varying interface is examined. The constituent materials are assumed to be homogenous, isotropic, elastic and having different mechanical properties. By employing the method of multiple scales, a nonlinear Schrödinger equation (NLS) with variable coefficients is derived for the nonlinear self-modulation of SH waves. We examine the effects of dispersion, irregularity of the interface and nonlinearity on the propagation characteristics of SH waves.

  5. 2-D deformation of two welded half-spaces due to a blind dip-slip fault

    Indian Academy of Sciences (India)

    Sunita Rani; Neeru Bala

    2006-06-01

    The solution of two-dimensional problem of an interface breaking long inclined dip-slip fault in two welded half-spaces is well known.The purpose of this note is to obtain the corresponding solution for a blind fault.The solution is valid for arbitrary values of the fault-depth and the dip angle.Graphs showing the variation of the displacement field with the distance from the fault, for different values of fault depth and dip angle are presented.Contour maps showing the stress field around a long dip-slip fault are also obtained.

  6. Benchmark solution for vibrations from a moving point source in a tunnel embedded in a half-space

    Science.gov (United States)

    Yuan, Zonghao; Boström, Anders; Cai, Yuanqiang

    2017-01-01

    A closed-form semi-analytical solution for the vibrations due to a moving point load in a tunnel embedded in a half-space is given in this paper. The tunnel is modelled as an elastic hollow cylinder and the ground surrounding the tunnel as a linear viscoelastic material. The total wave field in the half-space with a cylindrical hole is represented by outgoing cylindrical waves and down-going plane waves. To apply the boundary conditions on the ground surface and at the tunnel-soil interface, the transformation properties between the plane and cylindrical wave functions are employed. The proposed solution can predict the ground vibration from an underground railway tunnel of circular cross-section with a reasonable computational effort and can serve as a benchmark solution for other computational methods. Numerical results for the ground vibrations on the free surface due to a moving constant load and a moving harmonic load applied at the tunnel invert are presented for different load velocities and excitation frequencies. It is found that Rayleigh waves play an important role in the ground vibrations from a shallow tunnel.

  7. Consolidation of a poroelastic half-space with anisotropic permeability and compressible constituents by axisymmetric surface loading

    Indian Academy of Sciences (India)

    Sarva Jit Singh; Raman Kumar; Sunita Rani

    2009-10-01

    The fully coupled Biot quasi-static theory of linear poroelasticity is used to study the consolidation of a poroelastic half-space caused by axisymmetric surface loads.The fluid and solid constituents of the poroelastic medium are compressible and its permeability in the vertical direction is different from its permeability in the horizontal direction.An analytical solution of the governing equations is obtained by taking the displacements and the pore pressure as the basic state variables and using a combination of the Laplace and Hankel transforms.The problem of an axisymmetric normal load is discussed in detail.An explicit analytical solution is obtained for normal disc loading.Detailed numerical computations reveal that the anisotropy in permeability as well as the com-pressibilities of the fluid and solid constituents of the poroelastic medium have significant effects on the consolidation of the half-space.The anisotropy in permeability may accelerate the consolidation process and may lead to a dilution in the theoretical prediction of the Mandel –Cryer effect. The compressibility of the solid constituents may also accelerate the consolidation process.

  8. Effect of coseismic and postseismic deformation on homogeneous and layered half-space and spherical analysis: Model simulation of the 2006 Java, Indonesia, tsunami earthquake

    Science.gov (United States)

    Gunawan, Endra; Meilano, Irwan; Hanifa, Nuraini Rahma; Widiyantoro, Sri

    2017-10-01

    We simulate surface displacements calculated on homogeneous and layered half-space and spherical models as applied to the coseismic and postseismic (afterslip and viscoelastic relaxation) of the 2006 Java tsunami earthquake. Our analysis of coseismic and afterslip deformation suggests that the homogeneous half-space model generates a much broader displacement effect than the layered half-space and spherical models. Also, though the result for surface displacements is similar for the layered half-space and spherical models, noticeable displacements still occurred on top of the coseismic fault patches. Our displacement result in afterslip modeling suggests that significant displacements occurred on top of the main afterslip fault patches, differing from the viscoelastic relaxation model, which has displacements in the front region of coseismic fault patches. We propose this characteristic as one of the important features differentiating a postseismic deformation signal from afterslip and viscoelastic relaxation detected by geodetic data.

  9. Treatment Outcome of Two Adjacent Implant-Supported Restorations with Different Implant Platform Designs in the Esthetic Region : A Five-Year Randomized Clinical Trial

    NARCIS (Netherlands)

    Van Nimwegen, Wouter G.; Raghoebar, Gerry M.; Stellingsma, Kees; Tymstra, Nynke; Vissink, Arjan; Meijer, Henny J. A.

    2015-01-01

    Purpose: The aim of this study was to evaluate the peri-implant soft and hard tissues and satisfaction in patients with two adjacent implant-supported restorations in the esthetic region, treated with two adjacent implants with a scalloped or flat platform. Materials and Methods: The randomized clin

  10. Measuring Ventilatory Activity with Structured Light Plethysmography (SLP Reduces Instrumental Observer Effect and Preserves Tidal Breathing Variability in Healthy and COPD

    Directory of Open Access Journals (Sweden)

    Marie-Cécile Niérat

    2017-05-01

    Full Text Available The use of a mouthpiece to measure ventilatory flow with a pneumotachograph (PNT introduces a major perturbation to breathing (“instrumental/observer effect” and suffices to modify the respiratory behavior. Structured light plethysmography (SLP is a non-contact method of assessment of breathing pattern during tidal breathing. Firstly, we validated the SLP measurements by comparing timing components of the ventilatory pattern obtained by SLP vs. PNT under the same condition; secondly, we compared SLP to SLP+PNT measurements of breathing pattern to evaluate the disruption of breathing pattern and breathing variability in healthy and COPD subjects. Measurements were taken during tidal breathing with SLP alone and SLP+PNT recording in 30 COPD and healthy subjects. Measurements included: respiratory frequency (Rf, inspiratory, expiratory, and total breath time/duration (Ti, Te, and Tt. Passing-Bablok regression analysis was used to evaluate the interchangeability of timing components of the ventilatory pattern (Rf, Ti, Te, and Tt between measurements performed under the following experimental conditions: SLP vs. PNT, SLP+PNT vs. SLP, and SLP+PNT vs. PNT. The variability of different ventilatory variables was assessed through their coefficients of variation (CVs. In healthy: according to Passing-Bablok regression, Rf, TI, TE and TT were interchangeable between measurements obtained under the three experimental conditions (SLP vs. PNT, SLP+PNT vs. SLP, and SLP+PNT vs. PNT. All the CVs describing “traditional” ventilatory variables (Rf, Ti, Te, Ti/Te, and Ti/Tt were significantly smaller in SLP+PNT condition. This was not the case for more “specific” SLP-derived variables. In COPD: according to Passing-Bablok regression, Rf, TI, TE, and TT were interchangeable between measurements obtained under SLP vs. PNT and SLP+PNT vs. PNT, whereas only Rf, TE, and TT were interchangeable between measurements obtained under SLP+PNT vs. SLP. However, most

  11. 2-D Deformation analysis of a half-space due to a long dip-slip fault at finite depth

    Indian Academy of Sciences (India)

    Sushil K Tomar; Naresh K Dhiman

    2003-12-01

    Closed form analytical expressions of stresses and displacements at any field point due to a very long dip-slip fault of finite width buried in a homogeneous, isotropic elastic half-space, are presented. Airy stress function is used to derive the expressions of stresses and displacements which depend on the dip angle and depth of the upper edge of the fault. The effect of dip angle and depth of the upper edge of the fault on stresses and displacements is studied numerically and the results obtained are presented graphically. Contour maps for stresses and displacements are also presented. The results of Rani and Singh (1992b) and Freund and Barnett (1976) have been reproduced.

  12. Reflection of plane waves at the free surface of a fibre-reinforced elastic half-space

    Indian Academy of Sciences (India)

    Baljeet Singh; Sarva Jit Singh

    2004-06-01

    The propagation of plane waves in fibre-reinforced, anisotropic, elastic media is discussed. The expressions for the phase velocity of quasi-$P(qP)$ and quasi-$SV(qSV)$ waves propagating in a plane containing the reinforcement direction are obtained as functions of the angle between the propagation and reinforcement directions. Closed form expressions for the amplitude ratios for qP and qSV waves reflected at the free surface of a fibre-reinforced, anisotropic, homogeneous, elastic half-space are obtained. These expressions are used to study the variation of amplitude ratios with angle of incidence. It is found that reinforcement has a significant effect on the amplitude ratios and critical angle.

  13. Velocity overshoot of start-up flow for a Maxwell fluid in a porous half-space

    Institute of Scientific and Technical Information of China (English)

    Tan Wen-Chang

    2006-01-01

    Stokes' first problem has been investigated for a Maxwell fluid in a porous half-space for gaining insight into the effect of viscoelasticity on the start-up flow in a porous medium. An exact solution was obtained by using the Fourier sine transform. It was found that at large values of the relaxation time the velocity overshoot occurs obviously and the system exhibits viscoelastic behaviours. On the other hand, for short relaxation time the velocity overshoot disappears and the system exhibits viscous behaviours. A critical value of the relaxation time was obtained for the emergence of the velocity overshoot. Furthermore, it was found that the velocity overshoot is caused by both the viscoelasticity of the Maxwell fluid and the Darcy resistance resulting from the structure of the micropore in the porous medium.

  14. Reflection of P-Wave and Sv-Wave in a Generalized Two Temperature Thermoelastic Half-Space

    Directory of Open Access Journals (Sweden)

    Santra S.

    2014-11-01

    Full Text Available In this work the theory of two temperature generalized thermoelasticity has been used to investigate the problem of reflection of P-wave and SV-wave in a half space when the surface is i thermally insulated or ii isothermal. The ratios of the reflection coefficient to that of the incident coefficient for different cases are obtained for P-wave and SV-waves. The results for various cases for the conductive and dynamical temperature have been compared. The results arrived at in the absence of the thermal field (elastic case have also been compared with those in the existing literature. Finally, the results for various cases have been analyzed and depicted in graphs.

  15. Steady-State Response of a Micropolar Generalized Thermoelastic Half-Space to the Moving Mechanical/Thermal Loads

    Indian Academy of Sciences (India)

    Rajneesh Kumar; Sunita Deswal

    2000-11-01

    Microrotation effect of a load applied normal to the boundary and moving at a constant velocity along one of the co-ordinate axis in a generalized thermoelastic half-space is studied. The analytical expressions of the displacement component, force stress, couple stress and temperature field for two different theories i.e. Lord-Shulman (L-S) and Green-Lindsay (G-L) for supersonic, subsonic and transonic velocities in case of mechanical and thermal sources applied, are obtained by the use of Fourier transform technique. The integral transforms have been inverted by using a numerical technique and the numerical results are illustrated graphically for magnesium crystal-like material.

  16. Scattering of electromagnetic waves from a half-space of randomly distributed discrete scatterers and polarized backscattering ratio law

    Science.gov (United States)

    Zhu, P. Y.

    1991-01-01

    The effective-medium approximation is applied to investigate scattering from a half-space of randomly and densely distributed discrete scatterers. Starting from vector wave equations, an approximation, called effective-medium Born approximation, a particular way, treating Green's functions, and special coordinates, of which the origin is set at the field point, are used to calculate the bistatic- and back-scatterings. An analytic solution of backscattering with closed form is obtained and it shows a depolarization effect. The theoretical results are in good agreement with the experimental measurements in the cases of snow, multi- and first-year sea-ice. The root product ratio of polarization to depolarization in backscattering is equal to 8; this result constitutes a law about polarized scattering phenomena in the nature.

  17. Two groups of S-layer proteins, SLP1s and SLP2s, in Bacillus thuringiensis co-exist in the S-layer and in parasporal inclusions.

    Science.gov (United States)

    Zhou, Zhou; Peng, Donghai; Zheng, Jinshui; Guo, Gang; Tian, Longjun; Yu, Ziniu; Sun, Ming

    2011-05-01

    We screened four B. thuringiensis strains whose parasporal inclusions contained the S-layer protein (SLP), and cloned two slp genes from each strain. Phylogenetic analysis indicated these SLPs could be divided into two groups, SLP1s and SLP2s. To confirm whether SLPs were present in the S-layer or as a parasporal inclusion, strains CTC and BMB1152 were chosen for further study. Western blots with whole-cell associated proteins from strains CTC and BMB1152 in the vegetative phase showed that SLP1s and SLP2s were constituents of the S-layer. Immunofluorescence utilizing spore-inclusion mixtures of strains CTC and BMB1152 in the sporulation phase showed that SLP1s and SLP2s were also constituents of parasporal inclusions. When heterogeneously expressed in the crystal negative strain BMB171, four SLPs from strains CTC and BMB1152 could also form parasporal inclusions. This temporal and spatial expression is not an occasional phenomenon but ubiquitous in B. thuringiensis strains.

  18. Wave scattering of complex local site in a layered half-space by using a multidomain IBEM: incident plane SH waves

    Science.gov (United States)

    Ba, Zhenning; Yin, Xiao

    2016-06-01

    A multidomain indirect boundary element method (IBEM) is proposed to study the wave scattering of plane SH waves by complex local site in a layered half-space. The new method, using both the full-space and layered half-space Green's functions as its fundamental solutions can also be regarded as a coupled method of the full-space IBEM and half-space IBEM. First, the whole model is decomposed into independent closed regions and an opened layered half-space region with all of the irregular interfaces; then, fictitious uniformly distributed loads are applied separately on the boundaries of each region, and scattered fields of the closed regions and the opened layered half-space region are constructed by calculating the full-space and layered half-space Green's functions, respectively; finally, all of the regions are assembled to establish the linear algebraic system that arises from discretization. The densities of the distributed loads are determined directly by solving the algebraic system. The accuracy and capability of the new approach are verified extensively by comparing its results with those of published approaches for a class of hills, valleys and embedded inclusions. And the capability of the new method is further displayed when it is used to investigate a hill-triple layered valley-hill coupled topography in a multilayered half-space. All of the numerical calculations presented in this paper demonstrate that the new method is very suitable for solving multidomain coupled multilayered wave scattering problems with the merits of high accuracy and representing the scattered fields in different kinds of regions more reasonably and flexibly.

  19. Numerical Modeling of Surface Deformation due to Magma Chamber Inflation/Deflation in a Heterogeneous Viscoelastic Half-space

    Science.gov (United States)

    Dichter, M.; Roy, M.

    2015-12-01

    Interpreting surface deformation patterns in terms of deeper processes in regions of active magmatism is challenging and inherently non-unique. This study focuses on interpreting the unusual sombrero-shaped pattern of surface deformation in the Altiplano Puna region of South America, which has previously been modeled as the effect of an upwelling diapir of material in the lower crust. Our goal is to investigate other possible interpretations of the surface deformation feature using a suite of viscoelastic models with varying material heterogeneity. We use the finite-element code PyLith to study surface deformation due to a buried time-varying (periodic) overpressure source, a magma body, at depth within a viscoelastic half-space. In our models, the magma-body is a penny-shaped crack, with a cylindrical region above the crack that is weak relative to the surrounding material. We initially consider a magma body within a homogeneous viscoelastic half-space to determine the effect of the free surface upon deformation above and beneath the source region. We observe a complex depth-dependent phase relationship between stress and strain for elements that fall between the ground surface and the roof of the magma body. Next, we consider a volume of weak material (faster relaxation time relative to background) that is distributed with varying geometry around the magma body. We investigate how surface deformation is governed by the spatial distribution of the weak material and its rheologic parameters. We are able to reproduce a "sombrero" pattern of surface velocities for a range of models with material heterogeneity. The wavelength of the sombrero pattern is primarily controlled by the extent of the heterogeneous region, modulated by flexural effects. Our results also suggest an "optimum overpressure forcing frequency" where the lifetime of the sombrero pattern (a transient phenomenon due to the periodic nature of the overpressure forcing) reaches a maximum. Through further

  20. Program Intensity and Service Delivery Models in the Schools: SLP Survey Results

    Science.gov (United States)

    Brandel, Jayne; Loeb, Diane Frome

    2011-01-01

    Purpose: School-based speech-language pathologists (SLPs) routinely work with team members to make recommendations regarding an intervention program's intensity and method of service delivery for children with speech and language impairments. In this study, student, SLP, and workplace characteristics that may influence SLPs' recommendations were…

  1. Silkworm larvae plasma (SLP) assay for detection of bacteria: False positives secondary to inflammation in vivo.

    Science.gov (United States)

    Ma, Michelle; Rice, Tyler A; Percopo, Caroline M; Rosenberg, Helene F

    2017-01-01

    The silkworm larvae plasma (SLP) assay has been developed as a means to detect bacterial peptidoglycan as a surrogate for live bacteria. Here, we present results that indicate that generation of melanin by this assay is not fully reliable as a surrogate marker for bacterial count.

  2. Direct current electric potential in an anisotropic half-space with vertical contact containing a conductive 3D body

    Directory of Open Access Journals (Sweden)

    Li Ping

    2004-01-01

    Full Text Available Detailed studies of anomalous conductors in otherwise homogeneous media have been modelled. Vertical contacts form common geometries in galvanic studies when describing geological formations with different electrical conductivities on either side. However, previous studies of vertical discontinuities have been mainly concerned with isotropic environments. In this paper, we deal with the effect on the electric potentials, such as mise-à-la-masse anomalies, due to a conductor near a vertical contact between two anisotropic regions. We also demonstrate the interactive effects when the conductive body is placed across the vertical contact. This problem is normally very difficult to solve by the traditional numerical methods. The integral equations for the electric potential in anisotropic half-spaces are established. Green's function is obtained using the reflection and transmission image method in which five images are needed to fit the boundary conditions on the vertical interface and the air-earth surface. The effects of the anisotropy of the environments and the conductive body on the electric potential are illustrated with the aid of several numerical examples.

  3. Effect of source parameters on forward-directivity velocity pulse for vertical strike slip fault in half space

    Institute of Scientific and Technical Information of China (English)

    Liu Qifang; Yuan Yifan; Jin Xing

    2006-01-01

    It has been found that the large velocity pulse is one of the most important characteristics of near-fault strong ground motions. Some statistical relationships between pulse period and the moment magnitude for near-fault strong ground motions have been established by Somerville (1998); Alavi and Krawinkler ( 2000); and Mavroeidis and Papageorgiou (2003), where no variety of rupture velocity, fault depth, and fault distance, etc. were considered. Since near-fault ground motions are significantly influenced by the rupture process and source parameters, the effects of some source parameters on the amplitude and the period of a forward-directivity velocity pulse in a half space are analyzed by the finite difference method combined with the kinematic source model in this paper. The study shows that the rupture velocity, fault depth, position of the initial rupture point and distribution of asperities are the most important parameters to the velocity pulse. Generally, the pulse period decreases and the pulse amplitude increases as the rupture velocity increases for shallow crustal earthquakes. In a definite region besides the fault trace, the pulse period increases as the fault depth increases. For a uniform strike slip fault,rupture initiating from one end of a fault and propagating to the other always generates a higher pulse amplitude and longer pulse period than in other cases.

  4. Effect of source parameters on forward-directivity velocity pulse for vertical strike slip fault in half space

    Science.gov (United States)

    Liu, Qifang; Yuan, Yifan; Jin, Xing

    2006-06-01

    It has been found that the large velocity pulse is one of the most important characteristics of near-fault strong ground motions. Some statistical relationships between pulse period and the moment magnitude for near-fault strong ground motions have been established by Somerville (1998); Alavi and Krawinkler (2000); and Mavroeidis and Papageorgiou (2003), where no variety of rupture velocity, fault depth, and fault distance, etc. were considered. Since near-fault ground motions are significantly influenced by the rupture process and source parameters, the effects of some source parameters on the amplitude and the period of a forward-directivity velocity pulse in a half space are analyzed by the finite difference method combined with the kinematic source model in this paper. The study shows that the rupture velocity, fault depth, position of the initial rupture point and distribution of asperities are the most important parameters to the velocity pulse. Generally, the pulse period decreases and the pulse amplitude increases as the rupture velocity increases for shallow crustal earthquakes. In a definite region besides the fault trace, the pulse period increases as the fault depth increases. For a uniform strike slip fault, rupture initiating from one end of a fault and propagating to the other always generates a higher pulse amplitude and longer pulse period than in other cases.

  5. Dynamic interaction of twin vertically overlapping lined tunnels in an elastic half space subjected to incident plane waves

    Science.gov (United States)

    Liu, Zhongxian; Wang, Yirui; Liang, Jianwen

    2016-06-01

    The scattering of plane harmonic P and SV waves by a pair of vertically overlapping lined tunnels buried in an elastic half space is solved using a semi-analytic indirect boundary integration equation method. Then the effect of the distance between the two tunnels, the stiffness and density of the lining material, and the incident frequency on the seismic response of the tunnels is investigated. Numerical results demonstrate that the dynamic interaction between the twin tunnels cannot be ignored and the lower tunnel has a significant shielding effect on the upper tunnel for high-frequency incident waves, resulting in great decrease of the dynamic hoop stress in the upper tunnel; for the low-frequency incident waves, in contrast, the lower tunnel can lead to amplification effect on the upper tunnel. It also reveals that the frequency-spectrum characteristics of dynamic stress of the lower tunnel are significantly different from those of the upper tunnel. In addition, for incident P waves in low-frequency region, the soft lining tunnels have significant amplification effect on the surface displacement amplitude, which is slightly larger than that of the corresponding single tunnel.

  6. Generalization of von Neumann analysis for a model of two discrete half-spaces: The acoustic case

    Science.gov (United States)

    Haney, M.M.

    2007-01-01

    Evaluating the performance of finite-difference algorithms typically uses a technique known as von Neumann analysis. For a given algorithm, application of the technique yields both a dispersion relation valid for the discrete time-space grid and a mathematical condition for stability. In practice, a major shortcoming of conventional von Neumann analysis is that it can be applied only to an idealized numerical model - that of an infinite, homogeneous whole space. Experience has shown that numerical instabilities often arise in finite-difference simulations of wave propagation at interfaces with strong material contrasts. These interface instabilities occur even though the conventional von Neumann stability criterion may be satisfied at each point of the numerical model. To address this issue, I generalize von Neumann analysis for a model of two half-spaces. I perform the analysis for the case of acoustic wave propagation using a standard staggered-grid finite-difference numerical scheme. By deriving expressions for the discrete reflection and transmission coefficients, I study under what conditions the discrete reflection and transmission coefficients become unbounded. I find that instabilities encountered in numerical modeling near interfaces with strong material contrasts are linked to these cases and develop a modified stability criterion that takes into account the resulting instabilities. I test and verify the stability criterion by executing a finite-difference algorithm under conditions predicted to be stable and unstable. ?? 2007 Society of Exploration Geophysicists.

  7. Effect of irregularity on torsional surface waves in an initially stressed anisotropic porous layer sandwiched between homogeneous and non-homogeneous half-space

    Indian Academy of Sciences (India)

    Anup Saha; Santimoy Kundu; Shishir Gupta; Pramod Kumar Vaishnav

    2016-06-01

    The present paper is concerned with the propagation of torsional surface waves in an initially stressedanisotropic porous layer sandwiched between homogeneous and non-homogeneous half-space. We assumethe quadratic inhomogeneity in rigidity and density in the lower half-space and irregularity is taken inthe form of rectangle at the interface separating the layer from the lower half-space. The dispersionequation for torsional waves has been obtained in a closed form. Velocity equation is also obtained inthe absence of irregularity. The study reveals that the presence of irregularity, initial stress, porosity,inhomogeneity and anisotropy factor in the dispersion equation approves the significant effect of theseparameters in the propagation of torsional waves in porous medium. It has also been observed that fora uniform media, the velocity equation reduces to the classical result of Love wave.

  8. Effect of irregularity on torsional surface waves in an initially stressed anisotropic porous layer sandwiched between homogeneous and non-homogeneous half-space

    Science.gov (United States)

    Saha, Anup; Kundu, Santimoy; Gupta, Shishir; Vaishnav, Pramod Kumar

    2016-06-01

    The present paper is concerned with the propagation of torsional surface waves in an initially stressed anisotropic porous layer sandwiched between homogeneous and non-homogeneous half-space. We assume the quadratic inhomogeneity in rigidity and density in the lower half-space and irregularity is taken in the form of rectangle at the interface separating the layer from the lower half-space. The dispersion equation for torsional waves has been obtained in a closed form. Velocity equation is also obtained in the absence of irregularity. The study reveals that the presence of irregularity, initial stress, porosity, inhomogeneity and anisotropy factor in the dispersion equation approves the significant effect of these parameters in the propagation of torsional waves in porous medium. It has also been observed that for a uniform media, the velocity equation reduces to the classical result of Love wave.

  9. Generating a Homogeneous Dose Distribution in the Junction Region between Two Adjacent Fields in Electron Beam Therapy

    Directory of Open Access Journals (Sweden)

    Mohammad Javad Tahmasebi Birgani

    2010-09-01

    Full Text Available Introduction: Treatment with megavoltage electron beams is ideal for irradiating superficial tumors because of their limited range in tissues. However, for electron treatment of extended areas, such as the chest wall, two or more adjacent fields can be used. Abutment of these fields may lead to significant dose in homogeneities in the junction region. The aim of this study is to offer a new method for generating a homogeneous dose distribution in the junction region between two adjacent fields in electron beam therapy. Materials and Methods: Several approaches have been proposed to solve the problem of ‘hot’ and ‘cold’ spots in the junction region between abutting electron fields. These techniques are based on beam-edge modifying devices or penumbra generators which act to broaden the electron beam penumbra, and thus facilitate field matching. But use of these devices is time consuming and design of the modifications to the applicators are generally applicator dependent. An idea which was originally proposed for matching two adjacent photon fields (with dose inhomogeneity of about 2% is resurrected here. This method is based on the rotation of the gantry such that the adjacent fields have a common edge and the overlap region in treatment volume is eliminated. For this purpose, the effective source to surface distance (SSDeff for the available electron beam energies (6, 9, 12 and 15 MeV and applicators (cones (6 × 6, 10 × 10, 15 ×15, 20 × 20 and 25 × 25 cm2 have been determined for a Varian 2100C linear accelerator. Result: Using SSDeff, in respect to beam divergence, one can use the photon beam behavior for electron beams and achieve a uniform dose distribution in adjacent electron fields. Discussion and Conclusion: Compared to beam-edge modifying devices or penumbra generators that are usually time consuming to plan and set up, rotating the gantry to eliminate the overlap region is simple and applicable in the problem of abutting

  10. Bioaccessibility of heavy metals in soils cannot be predicted by a single model in two adjacent areas.

    Science.gov (United States)

    Zhu, Xiaodong; Yang, Fen; Wei, Chaoyang; Liang, Tao

    2016-02-01

    The objective of this study was to examine whether a single model could be used to predict the bioaccessibility of heavy metals in soils in two adjacent areas and to determine the feasibility of using existing data sets of total metal concentrations and soil property parameters (e.g., pH, total organic carbon, and soil texture) when predicting heavy metal bioaccessibility. A total of 103 topsoil samples were collected from two adjacent areas (Baotou and Bayan Obo). A total of 76 samples were collected from Baotou, and 27 were collected from Bayan Obo. The total and bioaccessible concentrations of arsenic (As), copper (Cu), lead (Pb), and zinc (Zn) were measured following complete composite acid digestion and a simple bioaccessibility extraction test. The average total concentrations of As, Cu, Pb, and Zn were 8.95, 27.53, 28.40, and 79.50 mg/kg, respectively, in Baotou and 18.12, 30.75, 38.09, and 87.62 mg/kg in Bayan Obo. Except for As, these values were similar in both areas. The average bioaccessible heavy metal concentrations (Bio-HMs) for each target HM were also similar. In Baotou, the average Bio-HM values for As, Cu, Pb, and Zn were 1.16, 3.76, 16.31, and 16.10 mg/kg, respectively, and 1.26, 2.51, 14.31, and 8.68 mg/kg in Bayan Obo. However, the relative bioaccessibilities for each HM in Baotou were greater than those in Bayan Obo, with mean values for Pb, Zn, Cu, and As of 57, 20, 17, and 12 %, respectively, in Baotou and 40, 11, 9, and 8 % in Bayan Obo. In both areas, prediction models were successfully created using heavy metal concentrations and soil physicochemical parameters; however, models of the same target element differed between the areas, which indicated that a common model for both sites does not exist. Bio-HMs were highly affected by soil properties, which were found to differ between the adjacent areas. In addition, soil properties with large variations played major roles in the predictive models. This study highlights the importance

  11. Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function

    Science.gov (United States)

    Navas, Victor H.; Cuche, Céline; Alcover, Andres

    2017-01-01

    The adapter protein SLP76 is a key orchestrator of T cell receptor (TCR) signal transduction. We previously identified a negative feedback loop that modulates T cell activation, involving phosphorylation of Ser376 of SLP76 by the hematopoietic progenitor kinase 1 (HPK1). However, the physiological relevance of this regulatory mechanism was still unknown. To address this question, we generated a SLP76-S376A-expressing knock-in mouse strain and investigated the effects of Ser376 mutation on T cell development and function. We report here that SLP76-S376A-expressing mice exhibit normal thymocyte development and no detectable phenotypic alterations in mature T cell subsets or other lymphoid and myeloid cell lineages. Biochemical analyses revealed that mutant T cells were hypersensitive to TCR stimulation. Indeed, phosphorylation of several signaling proteins, including SLP76 itself, phospholipase Cγ1 and the protein kinases AKT and ERK1/2, was increased. These modifications correlated with increased Th1-type and decreased Th2-type cytokine production by SLP76-S376A T cells, but did not result in significant changes of proliferative capacity nor activation-induced cell death susceptibility. Hence, our results reveal that SLP76-Ser376 phosphorylation does not mediate all HPK1-dependent regulatory effects in T cells but it fine-tunes helper T cell responses. PMID:28107427

  12. Mammal occurrence and roadkill in two adjacent ecoregions (Atlantic Forest and Cerrado in south-western Brazil

    Directory of Open Access Journals (Sweden)

    Nilton C. Cáceres

    2010-10-01

    Full Text Available This paper examines the frequencies of mammal roadkill in two adjacent biogeographic ecoregions (Atlantic Forest and Cerrado of Brazil. Mammals were recorded during a seven-year period and over 3,900 km of roads, in order to obtain data for frequencies of species in habitats (sites and frequencies of species killed by cars on roads. Sites (n = 80 within ecoregions (Cerrado, n = 57; Atlantic Forest, n = 23 were searched for records of mammals. Species surveyed in the entire region totaled 33, belonging to nine orders and 16 families. In the Cerrado, 31 species were recorded in habitats; of these, 25 were found dead on roads. In the Atlantic Forest ecoregions, however, we found 21 species in habitats, 16 of which were also found dead on roads. There was no overall significant difference between ecoregions for frequencies of occurrence in habitats or for roadkills, but there were differences between individual species. Hence, anteaters were mostly recorded in the Cerrado ecoregion, whereas caviomorph rodents tended to be more frequent in the Atlantic Forest ecoregion (seen mainly by roadkills. The greater number of species (overall and threatened and the greater abundance of species records in the Cerrado suggest that this ecoregion has a greater biodiversity and is better conserved than the Atlantic Forest ecoregion, in the state of Mato Grosso do Sul, south-western Brazil.

  13. Overestimation of the second time interval replaces time-shrinking when the difference between two adjacent time intervals increases

    Directory of Open Access Journals (Sweden)

    Yoshitaka eNakajima

    2014-05-01

    Full Text Available When the onsets of three successive sound bursts mark two adjacent time intervals, the second time interval can be underestimated when it is physically longer than the first time interval by up to 100 ms. This illusion, time-shrinking, is very stable when the first time interval is 200 ms or shorter (Nakajima et al., 2004, Perception, 33. Time-shrinking had been considered a kind of perceptual assimilation to make the first and the second time interval more similar to each other. Here we investigated whether the underestimation of the second time interval was replaced by an overestimation if the physical difference between the neighboring time intervals was too large for the assimilation to take place; this was a typical situation in which a perceptual contrast could be expected. Three experiments to measure the overestimation/underestimation of the second time interval by the method of adjustment were conducted. The first time interval was varied from 40 to 280 ms, and such overestimations indeed took place when the first time interval was 80-280 ms. The overestimations were robust when the second time interval was longer than the first time interval by 240 ms or more, and the magnitude of the overestimation was larger than 100 ms in some conditions. Thus, a perceptual contrast to replace time-shrinking was established. An additional experiment indicated that this contrast did not affect the perception of the first time interval substantially: The contrast in the present conditions seemed unilateral.

  14. Mechanics of a contracting reservoir in an elastic half-space with an intervening visco-elasto-plastic layer

    Science.gov (United States)

    Mossop, A.; Fredrich, J. T.

    2004-12-01

    The extraction of fluids from porous rocks within the Earth's crust leads to localised volume strains. These in turn induce stress changes and displacements in the surrounding rock mass. The relationships between these processes are governed by the constitutive properties of the rocks. For the case of a poroelastic fluid reservoir in a linear-elastic matrix the mechanics are relatively well known and understood. In this study we extend these models by investigating the case of a contracting rock body (caused by declining pore pressure) embedded within a linear-elastic half space, but with the addition of a visco-elasto-plastic layer between the contracting reservoir and the free surface. The problem is of growing importance as the exploitation of hydrocarbon reservoirs beneath salt bodies occurs at ever greater depths in the deepwater Gulf of Mexico. This is because the creep properties of salt are strongly temperature dependent, so that as depths increase, and hence ambient temperatures, creep can occur at a rate that is impossible to ignore over the reservoir lifecycle. The models are explored using a finite element approach and make use of sophisticated salt constitutive models and large-deformation three-dimensional geomechanical simulation codes; the reservoir deformations are governed by either poro-elastic or cap plasticity constitutive laws. However, a general behaviour pattern can be observed: the visco-elasto-plastic salt layer tends to decouple the deformation fields from the free surface with stress and displacements accentuated below the salt. The magnitude of the increased horizontal displacements below the salt layer are relatively independent of the layer thickness. The accentuated vertical displacements though are more strongly dependent on the thickness of the salt layer. This work was performed at Sandia National Laboratories funded by the US DOE under Contract DE-AC04-94AL85000. Sandia is a multiprogam laboratory operated by Sandia Corporation

  15. Mutational analysis of a plant defensin from radish (Raphanus sativus L.) reveals two adjacent sites important for antifungal activity.

    Science.gov (United States)

    De Samblanx, G W; Goderis, I J; Thevissen, K; Raemaekers, R; Fant, F; Borremans, F; Acland, D P; Osborn, R W; Patel, S; Broekaert, W F

    1997-01-10

    Mutational analysis of Rs-AFP2, a radish antifungal peptide belonging to a family of peptides referred to as plant defensins, was performed using polymerase chain reaction-based site-directed mutagenesis and yeast as a system for heterologous expression. The strategy followed to select candidate amino acid residues for substitution was based on sequence comparison of Rs-AFP2 with other plant defensins exhibiting differential antifungal properties. Several mutations giving rise to peptide variants with reduced antifungal activity against Fusarium culmorum were identified. In parallel, an attempt was made to construct variants with enhanced antifungal activity by substituting single amino acids by arginine. Two arginine substitution variants were found to be more active than wild-type Rs-AFP2 in media with high ionic strength. Our data suggest that Rs-AFP2 possesses two adjacent sites that appear to be important for antifungal activity, namely the region around the type VI beta-turn connecting beta-strands 2 and 3, on the one hand, and the region formed by residues on the loop connecting beta-strand 1 and the alpha-helix and contiguous residues on the alpha-helix and beta-strand 3, on the other hand. When added to F. culmorum in a high ionic strength medium, Rs-AFP2 stimulated Ca2+ uptake by up to 20-fold. An arginine substitution variant with enhanced antifungal activity caused increased Ca2+ uptake by up to 50-fold, whereas a variant that was virtually devoid of antifungal activity did not stimulate Ca2+ uptake.

  16. Sources of heavy metals in surface sediments and an ecological risk assessment from two adjacent Plateau reservoirs.

    Directory of Open Access Journals (Sweden)

    Binbin Wu

    Full Text Available The concentrations of heavy metals (mercury (Hg, cadmium (Cd, lead (Pb, chromium (Cr, copper (Cu and arsenic (As in surface water and sediments were investigated in two adjacent drinking water reservoirs (Hongfeng and Baihua Reservoirs on the Yunnan-Guizhou Plateau in Southwest China. Possible pollution sources were identified by spatial and statistical analyses. For both reservoirs, Cd was most likely from industrial activities, and As was from lithogenic sources. For the Hongfeng Reservoir, Pb, Cr and Cu might have originated from mixed sources (traffic pollution and residual effect of former industrial practices, and the sources of Hg included the inflows, which were different for the North (industrial activities and South (lithogenic origin Lakes, and atmospheric deposition resulting from coal combustion. For the Baihua Reservoir, the Hg, Cr and Cu were primarily derived from industrial activities, and the Pb originated from traffic pollution. The Hg in the Baihua Reservoir might also have been associated with coal combustion pollution. An analysis of ecological risk using sediment quality guidelines showed that there were moderate toxicological risks for sediment-dwelling organisms in both reservoirs, mainly from Hg and Cr. Ecological risk analysis using the Hakanson index suggested that there was a potential moderate to very high ecological risk to humans from fish in both reservoirs, mainly because of elevated levels of Hg and Cd. The upstream Hongfeng Reservoir acts as a buffer, but remains an important source of Cd, Cu and Pb and a moderately important source of Cr, for the downstream Baihua Reservoir. This study provides a replicable method for assessing aquatic ecosystem health in adjacent plateau reservoirs.

  17. Efficient Numerical Modeling of 3D, Half-Space, Slow-Slip and Quasi-Dynamic Earthquake Ruptures

    Science.gov (United States)

    Bradley, A. M.; Segall, P.

    2011-12-01

    Motivated by the hypothesis that dilatancy plays a critical role in faulting in subduction zones, we are developing FDRA2 (Fault Dynamics with the Radiation-damping Approximation), a software package to simulate three-dimensional quasi-dynamic faulting that includes rate-state friction, thermal pressurization, and dilatancy (following Segall and Rice [1995]) in a finite-width shear zone. This work builds on the two-dimensional simulations performed by FDRA1 (Bradley and Segall [AGU 2010], Segall and Bradley [submitted]). These simulations show that at lower background effective normal stress (\\bar σ), slow slip events occur spontaneously, whereas at higher \\bar σ , slip is inertially limited. At intermediate \\bar σ , dynamic events are followed by quiescent periods and then long durations of repeating slow slip events. Models with depth-dependent properties produce sequences similar to those observed in Cascadia. Like FDRA1, FDRA2 solves partial differential equations in pressure and temperature on profiles normal to the fault. The diffusion equations are discretized in space using finite differences on a nonuniform mesh having greater density near the fault. The full system of equations is a semiexplicit index-1 differential algebraic equation (DAE) in slip, slip rate, state, fault zone porosity, pressure, and temperature. We integrate state, porosity, and slip explicitly; solve the momentum balance equation on the fault for slip rate; and integrate pressure and temperature implicitly. Adaptive time steps are limited by accuracy and the stability criterion governing explicit integration of hyperbolic, but not the more stringent one governing parabolic, PDE. To compute elasticity in a 3D half-space, FDRA2 compresses the large, dense matrix arising from the boundary element method using an H-matrix. The work to perform a matrix-vector product scales almost linearly, rather than quadratically, in the number of fault cells. A new technique to relate the error

  18. Fission yeast APC/C activators Slp1 and Fzr1 sequentially trigger two consecutive nuclear divisions during meiosis.

    Science.gov (United States)

    Chikashige, Yuji; Yamane, Miho; Okamasa, Kasumi; Osakada, Hiroko; Tsutsumi, Chihiro; Nagahama, Yuki; Fukuta, Noriko; Haraguchi, Tokuko; Hiraoka, Yasushi

    2017-04-01

    In meiosis, two rounds of nuclear division occur consecutively without DNA replication between the divisions. We isolated a fission yeast mutant in which the nucleus divides only once to generate two spores, as opposed to four, in meiosis. In this mutant, we found that the initiation codon of the slp1(+) gene is converted to ATA, producing a reduced amount of Slp1. As a member of the Fizzy family of anaphase-promoting complex/cyclosome (APC/C) activators, Slp1 is essential for vegetative growth; however, the mutant allele shows a phenotype only in meiosis. Slp1 insufficiency delays degradation of maturation-promoting factor at the first meiotic division, and another APC/C activator, Fzr1, which acts late in meiosis, terminates meiosis immediately after the delayed first division to produce two viable spores. © 2017 Federation of European Biochemical Societies.

  19. The exact solution of the problem on a concentrated-force action on the isotropic half-space with the boundary fixed elastically

    Directory of Open Access Journals (Sweden)

    Nelly S. Khapilova

    2015-10-01

    Full Text Available We present the analytical solution of the axisymmetric mixed problem for the isotropic half-space with the surface fixed elastically outside the circular area of the application of a distributed load. In the solution of the problem, the transition procedure from a distributed load to the concentrated force has been justified. A compact form of the exact analytical solution of the problem on the concentrated force applied to the half-space with the surface fixed elastically was obtained. In the specific case when the proportionality factor of normal stresses and displacements vanishing under the condition of the elastic fixing of the boundary, the constructed analytical solution was shown to coincide with the well-known Boussinesq formulae.

  20. The Green¢s function of the harmonic horizontal force applied at the interior of the saturated half-space soil

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    By using integral transform methods, the Green's functions ofhorizontal harmonic force applied at the interior of the saturated half-space soil are obtained in the paper. The general solutions of the Biot dynamic equations in frequency domain are established through the use of Hankel integral transforms technique. Utilizing the above- mentioned general solutions, and the boundary conditions of the surface of the half-space and the continuous con-ditions at the plane of the horizontal force, the solutions of the boundary value problem can be determined. By the numerical inverse Hankel transforms method, the Green's functions of the harmonic horizontal force are obtainable. The degenerate case of the results deduced from this paper agrees well with the known results. Two numerical examples are given in the paper.

  1. Disturbance of SH-type waves due to moving stress discontinuity in an anisotropic soil layer overlying an inhomogeneous elastic half-space

    Indian Academy of Sciences (India)

    D Mandal; P C Pal; S Kumar

    2014-04-01

    The disturbance and propagation of SH-type waves in an anisotropic soil layer overlying an inhomogeneous elastic half-space by a moving stress discontinuity is considered. Stress discontinuity moves with non-uniform velocity and is impulsive in nature. The displacements are obtained in exact form by themethod due to Cagniard modified by de Hoop. The numerical result is calculated for special cases and the natures are depicted graphically.

  2. Roles of soil-structure interaction and damping in base-isolated structures built on numerous soil layers overlying a half-space

    Science.gov (United States)

    Tsai, C. S.; Hsueh, C. I.; Su, H. C.

    2016-06-01

    This study examines the roles of soil-structure interaction (SSI), higher modes, and damping in a base-isolated structure built on multiple layers of soil overlying a half space. Closed-form solutions for the entire system, including a superstructure, seismic isolator, and numerous soil layers overlying a half-space, were obtained. The formulations obtained in this study simply in terms of well-known frequencies and mechanical impedance ratios can explicitly interpret the dynamic behavior of a base-isolated structure interacting with multiple soil layers overlying a half-space. The key factors influencing the performance of the isolation system are the damping ratio of the isolator and the ratio of the natural frequency of the fixed-base structure to that of the isolated structure by assuming that the superstructure moves as a rigid body. This study reveals that higher damping in the base isolator is unfavorable to higher mode responses that usually dominate the responses of the superstructure and that the damping mechanism plays an important role in transmitting energy in addition to absorbing energy. It is also concluded that it is possible to design a soft soil layer as an isolation system for isolating vibration energy.

  3. On a technique for deriving the explicit secular equation of Rayleigh waves in an orthotropic half-space coated by an orthotropic layer

    Science.gov (United States)

    Vinh, P. C.; Anh, V. T. N.; Linh, N. T. K.

    2016-04-01

    The secular equation of Rayleigh propagating in an orthotropic half-space coated by an orthotropic layer has been obtained by Sotiropolous [Sotiropolous, D. A. (1999), The e®ect of anisotropy on guided elastic waves in a layered half-space, Mechanics of Materials 31, 215-233] and by Sotiropolous & Tougelidis [Sotiropolous, D. A. and Tougelidis, G. (1998), Guided elastic waves in orthotropic surface layer, Ultrasonics 36, 371-374]. However, it is not totally explicit and some misprints have occurred in this secular equation in both papers. This secular equation was derived by expanding directly a six-order determinant originated from the traction-free conditions at the top surface of the layer and the continuity of displacements and stresses through the interface between the layer and the half-space. Since the expansion of this six-order determinant was not shown in both two papers, it has been difficult to readers to recognize these misprints. This paper presents a technique that provides a totally explicit secular equation of the wave. The technique makes clear the way from the traction-free and continuity conditions to the secular equation and enables us to recognize the misprints appearing in the reported secular equation. The technique can be employed to obtain explicit secular equations of Rayleigh waves for many other cases. Moreover, the paper introduces a transfer matrix in explicit form for an orthotropic layer that is much simpler in form than the one obtained previously.

  4. Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.

    Science.gov (United States)

    Block, Helena; Herter, Jan M; Rossaint, Jan; Stadtmann, Anika; Kliche, Stefanie; Lowell, Clifford A; Zarbock, Alexander

    2012-02-13

    Neutrophils trigger inflammation-induced acute kidney injury (AKI), a frequent and potentially lethal occurrence in humans. Molecular mechanisms underlying neutrophil recruitment to sites of inflammation have proved elusive. In this study, we demonstrate that SLP-76 (SH2 domain-containing leukocyte phosphoprotein of 76 kD) and ADAP (adhesion and degranulation promoting adaptor protein) are involved in E-selectin-mediated integrin activation and slow leukocyte rolling, which promotes ischemia-reperfusion-induced AKI in mice. By using genetically engineered mice and transduced Slp76(-/-) primary leukocytes, we demonstrate that ADAP as well as two N-terminal-located tyrosines and the SH2 domain of SLP-76 are required for downstream signaling and slow leukocyte rolling. The Tec family kinase Bruton tyrosine kinase is downstream of SLP-76 and, together with ADAP, regulates PI3Kγ (phosphoinositide 3-kinase-γ)- and PLCγ2 (phospholipase Cγ2)-dependent pathways. Blocking both pathways completely abolishes integrin affinity and avidity regulation. Thus, SLP-76 and ADAP are involved in E-selectin-mediated integrin activation and neutrophil recruitment to inflamed kidneys, which may underlie the development of life-threatening ischemia-reperfusion-induced AKI in humans.

  5. Propionibacterium freudenreichii Surface Protein SlpB Is Involved in Adhesion to Intestinal HT-29 Cells

    Science.gov (United States)

    do Carmo, Fillipe L. R.; Rabah, Houem; Huang, Song; Gaucher, Floriane; Deplanche, Martine; Dutertre, Stéphanie; Jardin, Julien; Le Loir, Yves; Azevedo, Vasco; Jan, Gwénaël

    2017-01-01

    Propionibacterium freudenreichii is a beneficial bacterium traditionally used as a cheese ripening starter and more recently for its probiotic abilities based on the release of beneficial metabolites. In addition to these metabolites (short-chain fatty acids, vitamins, and bifidogenic factor), P. freudenreichii revealed an immunomodulatory effect confirmed in vivo by the ability to protect mice from induced acute colitis. This effect is, however, highly strain-dependent. Local action of metabolites and of immunomodulatory molecules is favored by the ability of probiotics to adhere to the host cells. This property depends on key surface compounds, still poorly characterized in propionibacteria. In the present study, we showed different adhesion rates to cultured human intestinal cells, among strains of P. freudenreichii. The most adhesive one was P. freudenreichii CIRM-BIA 129, which is known to expose surface-layer proteins. We evidenced here the involvement of these proteins in adhesion to cultured human colon cells. We then aimed at deciphering the mechanisms involved in adhesion. Adhesion was inhibited by antibodies raised against SlpB, one of the surface-layer proteins in P. freudenreichii CIRM-BIA 129. Inactivation of the corresponding gene suppressed adhesion, further evidencing the key role of slpB product in cell adhesion. This work confirms the various functions fulfilled by surface-layer proteins, including probiotic/host interactions. It opens new perspectives for the understanding of probiotic determinants in propionibacteria, and for the selection of the most efficient strains within the P. freudenreichii species. PMID:28642747

  6. AN INVESTIGATION ON TWO CRACKS PERPEN DICULAR TO THE INTERFACES IN A PIEZOE LECTRIC LAYER BONDED TO TWO HALF SPACES BY THE SCHMIDT METHOD

    Institute of Scientific and Technical Information of China (English)

    Zhou Zhengong; Du Shanyi

    2001-01-01

    The behavior of two collinear anti-plane shear cracks in a piezoelectric layer bonded to two half spaces is investigated by the Schmidt method. The cracks are vertically to the imerfaces of the piezoelectric layer. By using the Fourier transform, the problem can be solved with two pairs of triple integral equations. These equations are solved using the Schmidt method. This process is quite different from that adopted previously. Numerical examples are provided to show the effect of the geometry of the interacting cracks and the piezoelectric constants of the material upon the stress intensity factor of the cracks.

  7. Transient flow of a conducting fluid through a half-space and through a flat channel in a nonuniform external magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Antimirov, M.Ya.

    1978-01-01

    The transient flow of a conducting fluid in a nonuniform magnetic field is analyzed with consideration of the edge effect and in the zero-inductance (zero Prandtl number) approximation. The magnetic field induced by surface currents, first in only one thin wall and then in two thin walls, is calculated - with the current density described in terms of the delta function. The results of the general solution are then applied to flow through a half-space and through a flat channel under a pressure gradient, respectively. With the appropriate boundary conditions, Couette flow is considered as a special case. 8 references.

  8. The diffraction of Rayleigh waves by a fluid-saturated alluvial valley in a poroelastic half-space modeled by MFS

    Science.gov (United States)

    Liu, Zhongxian; Liang, Jianwen; Wu, Chengqing

    2016-06-01

    Two dimensional diffraction of Rayleigh waves by a fluid-saturated poroelastic alluvial valley of arbitrary shape in a poroelastic half-space is investigated using the method of fundamental solutions (MFS). To satisfy the free surface boundary conditions exactly, Green's functions of compressional (PI and PII) and shear (SV) wave sources buried in a fluid-saturated poroelastic half-space are adopted. Next, the procedure for solving the scattering wave field is presented. It is verified that the MFS is of excellent accuracy and numerical stability. Numerical results illustrate that the dynamic response strongly depends on such factors as the incident frequency, the porosity of alluvium, the boundary drainage condition, and the valley shape. There is a significant difference between the diffraction of Rayleigh waves for the saturated soil case and for the corresponding dry soil case. The wave focusing effect both on the displacement and pore pressure can be observed inside the alluvial valley and the amplification effect seems most obvious in the case of higher porosity and lower frequency. Additionally, special attention should also be paid to the concentration of pore pressure, which is closely related to the site liquefaction in earthquakes.

  9. Two-dimensional deformation of a uniform half-space due to non-uniform movement accompanying a long vertical tensile fracture

    Indian Academy of Sciences (India)

    Sunita Rani; Ram Chander Verma

    2013-08-01

    The solution of the static deformation of a homogeneous, isotropic, perfectly elastic half-space caused by uniform movement along a long vertical tensile fracture is well known. In this paper, we study the problem of static deformation of a homogeneous, isotropic, perfectly elastic half-space caused by a nonuniform movement along a long vertical tensile fracture of infinite length and finite depth. Four movement profiles are considered: linear, parabolic, elliptic and cubic. The deformation corresponding to the four non-uniform movement profiles is compared numerically with the deformation due to a uniform case, assuming the source potency to be the same. The equality in source potency is achieved in two ways: One, by varying the depth of fracture and keeping the surface discontinuity constant and the other way, by keeping the depth of fracture constant and varying the surface discontinuity. It is found that the effect of non-uniformity in movement in the near field is noteworthy. The far field is not affected significantly by the non-uniformity in movement. In the first case, horizontal displacement is significantly affected rather than vertical displacement. In the second case, non-uniformity in movement changes the magnitude of the displacement at the surface. Also, the displacements around a long vertical tensile fracture for different movement profiles are plotted in three dimensions.

  10. Amoebological study of the atmosphere of San Luis Potosi, SLP, Mexico.

    Science.gov (United States)

    Rodriguez-Zaragoza, S; Rivera, F; Bonilla, P; Ramirez, E; Gallegos, E; Calderon, A; Ortiz, R; Hernandez, D

    1993-01-01

    A one year round survey was conducted for isolation of free living amoebae (FLA) in the city of San Luis Potosi, (SLP), Mexico, which is placed in a desert environment. Samples were taken by modified impinger method and cultivated in laboratory conditions for FLA isolation following a week period of rehidration. 57 strains were isolated, 39% belonged to Acanthamoeba genus (which is important because it bears opportunistic pathogens that produce amoebic keratitis and granulomatous amoebic encephalitis in humans), 16% to Hartmannella, 9% to Vahlkampfia and the other proportion was divided among 6 other genera. The isolations were more abundant during dry season and the main genera were present in all four stands. The difference among them was the species variety which is discused as connected with abundance of organic wastes and lack of urbanization near the stations.

  11. The Perceptions of Students in the Allied Health Professions towards Stroke Rehabilitation Teams and the SLP's Role

    Science.gov (United States)

    Insalaco, Deborah; Ozkurt, Elcin; Santiago, Dign

    2007-01-01

    The purpose of this study was to determine the perceptions and knowledge of final-year speech-language pathology (SLP), physical and occupational therapy (PT, OT) students toward stroke rehabilitation teams and the SLPs' roles on them. The investigators adapted a survey developed by (Felsher & Ross, 1994) and administered it to 35 PT, 35 OT, and…

  12. Potentiation of a p53-SLP vaccine by cyclophosphamide in ovarian cancer : A single-arm phase II study

    NARCIS (Netherlands)

    Vermeij, Renee; Leffers, Ninke; Hoogeboom, Baukje-Nynke; Hamming, Ineke L. E.; Wolf, Rinze; Reyners, Anna K. L.; Molmans, Barbara H. W.; Hollema, Harry; Bart, Joost; Drijfhout, Jan W.; Oostendorp, Jaap; van der Zee, Ate G. J.; Melief, Cornelis J.; van der Burg, Sjoerd H.; Daemen, Toos; Nijman, Hans W.

    2012-01-01

    The purpose of the current phase II single-arm clinical trial was to evaluate whether pretreatment with low-dose cyclophosphamide improves immunogenicity of a p53-synthetic long peptide (SLP) vaccine in patients with recurrent ovarian cancer. Patients with ovarian cancer with elevated serum levels

  13. Long-term clinical and immunological effects of p53-SLP (R) vaccine in patients with ovarian cancer

    NARCIS (Netherlands)

    Leffers, Ninke; Vermeij, Renee; Hoogeboom, Baukje-Nynke; Schulze, Ute R.; Wolf, Rinze; Hamming, Ineke E.; van der Zee, Ate G.; Melief, Kees J.; van der Burg, Sjoerd H.; Daemen, Toos; Nijman, Hans W.

    2012-01-01

    Vaccine-induced p53-specific immune responses were previously reported to be associated with improved response to secondary chemotherapy in patients with small cell lung cancer. We investigated long-term clinical and immunological effects of the p53-synthetic long peptide (p53-SLP (R)) vaccine in pa

  14. STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a.

    Science.gov (United States)

    van Breevoort, Dorothee; Snijders, Ambrosius P; Hellen, Nicola; Weckhuysen, Sarah; van Hooren, Kathinka W E M; Eikenboom, Jeroen; Valentijn, Karine; Fernandez-Borja, Mar; Ceulemans, Berten; De Jonghe, Peter; Voorberg, Jan; Hannah, Matthew; Carter, Tom; Bierings, Ruben

    2014-05-15

    Vascular endothelial cells contain unique rod-shaped secretory organelles, called Weibel-Palade bodies (WPBs), which contain the hemostatic protein von Willebrand factor (VWF) and a cocktail of angiogenic and inflammatory mediators. We have shown that the Rab27A effector synaptotagmin-like protein 4-a (Slp4-a) plays a critical role in regulating hormone-evoked WPB exocytosis. Using a nonbiased proteomic screen for targets for Slp4-a, we now identify syntaxin-binding protein 1 (STXBP1) and syntaxin-2 and -3 as endogenous Slp4-a binding partners in endothelial cells. Coimmunoprecipitations showed that STXBP1 interacts with syntaxin-2 and -3, but not with syntaxin-4. Small interfering RNA-mediated silencing of STXBP1 expression impaired histamine- and forskolin-induced VWF secretion. To further substantiate the role of STXBP1, we isolated blood outgrowth endothelial cells (BOECs) from an early infantile epileptic encephalopathy type 4 (EIEE4) patient carrying a de novo mutation in STXBP1. STXBP1-haploinsufficient EIEE4 BOECs contained similar numbers of morphologically normal WPBs compared with control BOECs of healthy donors; however, EIEE4 BOECs displayed significantly impaired histamine- and forskolin-stimulated VWF secretion. Based on these findings, we propose that the Rab27A-Slp4-a complex on WPB promotes exocytosis through an interaction with STXBP1, thereby controlling the release of vaso-active substances in the vasculature.

  15. The Perceptions of Students in the Allied Health Professions towards Stroke Rehabilitation Teams and the SLP's Role

    Science.gov (United States)

    Insalaco, Deborah; Ozkurt, Elcin; Santiago, Dign

    2007-01-01

    The purpose of this study was to determine the perceptions and knowledge of final-year speech-language pathology (SLP), physical and occupational therapy (PT, OT) students toward stroke rehabilitation teams and the SLPs' roles on them. The investigators adapted a survey developed by (Felsher & Ross, 1994) and administered it to 35 PT, 35 OT, and…

  16. INVESTIGATION OF THE DYNAMIC BEHAVIOR OF TWO COLLINEAR ANTI-PLANE SHEAR CRACKS IN A PIEZOELECTRIC LAYER BONDED TO TWO HALF SPACES BY A NEW METOHD

    Institute of Scientific and Technical Information of China (English)

    周振功; 王彪

    2003-01-01

    The dynamic behavior of two collinear anti-plane shear cracks in a piezoelectriclayer bonded to two half spaces subjected to the harmonic waves is investigated by a newmethod. The cracks are parallel to the interfaces in the mid-plane of the piezoelectric layer.By using the Fourier transform, the problem can be solved with two pairs of triple integralequations. These equations are solved by using Schmidt's method. This process is quitedifferent from that adopted previously. Numerical examples are provided to show the effectof the geometry of cracks, the frequency of the incident wave, the thickness of thepiezoelectric layer and the constants of the materials upon the dynamic stress intensity factorof cracks.

  17. Polarimetric signatures of a layer of random nonspherical discrete scatterers overlying a homogeneous half-space based on first- and second-order vector radiative transfer theory

    Science.gov (United States)

    Tsang, Leung; Ding, Kung-Hau

    1991-01-01

    Complete polarimetric signatures of a layer of random, nonspherical discrete scatterers overlying a homogeneous half space are studied with the first- and second-order solutions of the vector radiative transfer theory. Some of the salient features of the numerical results are as follows: (1) the inclusion of the nondiagonal extinction matrix in the vector radiative transfer theory accounts for an appreciable phase difference between vv and hh polarizations, particularly for aligned scatterers; (2) the ensemble-averaged scattered Stokes vector is generally partially polarized, with the degree of polarization less than unity; (3) there generally exists a pedestal in the copolarization return when plotted as a function of ellipticity and orientation angles, which may be due to heterogeneity of scattering objects and/or multiple scattering effects; and (4) multiple scattering effects generally enhance the pedestal in copolarization return, decrease the degree of polarization, affect phase difference, and also enhance the depolarization return.

  18. Propagation of Surface Waves in a Homogeneous Layer of Finite Thickness over an Initially Stressed Functionally Graded Magnetic-Electric-Elastic Half-Space

    Directory of Open Access Journals (Sweden)

    Li Li

    2015-03-01

    Full Text Available The propagation behaviour of Love wave in an initially stressed functionally graded magnetic-electric-elastic half-space carrying a homogeneous layer is investigated. The material parameters in the substrate are assumed to vary exponentially along the thickness direction only. The velocity equations of Love wave are derived on the electrically or magnetically open circuit and short circuit boundary conditions, based on the equations of motion of the graded magnetic-electric-elastic mate- rial with the initial stresses and the free traction boundary conditions of surface and the continuous boundary conditions of interface. The dispersive curves are obtained numerically and the influences of the initial stresses and the material gradient index on the dispersive curves are dis- cussed. The investigation provides a basis for the development of new functionally graded magneto-electro-elastic surface wave devices.

  19. 浅析SLP法在企业设施布局的应用%Practice Process of SLP on Facility Layout Plan

    Institute of Scientific and Technical Information of China (English)

    赵涛; 赵双记; 林涛

    2012-01-01

    系统布置设计(Systematic Layout Planning,SLP)是一种系统性强、可操作性强的设施布局设计技术,本文回顾了SLP法在各类企业中的成功应用,并对该方法进一步的研究方向提出了意见.%Systematic Layout Planning, SLP is a systematic and manipuility method for facility layout plan. In this paper, the successful cases of facility layout plan using SLP were reviewed. And some suggestions for further research were given.

  20. Systematical analysis for the mixed couplings of two adjacent modified split ring resonators and the application to compact microstrip bandpass filters

    Science.gov (United States)

    Huang, Yongjun; Wen, Guangjun; Li, Jian

    2014-10-01

    In this paper we synthesize a new kind of modified split ring resonator (SRR) and characterize its mixed couplings between two adjacent such SRRs with all the possible arrangements on one side of a conventional dielectric substrate. Based on the analysis of the mixed couplings, the compact microstrip bandpass filters composed of the proposed modified SRRs are systematically analyzed. We found that two designs out of all the cases have quite well bandpass filter characteristics, e.g., low insert loss within the wide passband, sharp reductions and transmission zeros out of the passband, and harmonic suppression characteristics for a wide frequency range. Both experimental demonstrations and numerical simulations are performed to verify the designed filters and the results agree well with each other. Such kind of filter design can be flexibly integrated in the miniaturized radio frequency/microwave circuits.

  1. Systematical analysis for the mixed couplings of two adjacent modified split ring resonators and the application to compact microstrip bandpass filters

    Directory of Open Access Journals (Sweden)

    Yongjun Huang

    2014-10-01

    Full Text Available In this paper we synthesize a new kind of modified split ring resonator (SRR and characterize its mixed couplings between two adjacent such SRRs with all the possible arrangements on one side of a conventional dielectric substrate. Based on the analysis of the mixed couplings, the compact microstrip bandpass filters composed of the proposed modified SRRs are systematically analyzed. We found that two designs out of all the cases have quite well bandpass filter characteristics, e.g., low insert loss within the wide passband, sharp reductions and transmission zeros out of the passband, and harmonic suppression characteristics for a wide frequency range. Both experimental demonstrations and numerical simulations are performed to verify the designed filters and the results agree well with each other. Such kind of filter design can be flexibly integrated in the miniaturized radio frequency/microwave circuits.

  2. Satisfacción laboral y compromiso en las organizaciones de rio verde, S.L.P.

    Directory of Open Access Journals (Sweden)

    David Gómez Sánchez

    2013-05-01

    Full Text Available The main objective of this study is to identify the relationship between job satisfaction comprising three dimensions (with supervision, with the physical work environment and benefits received and organizational commitment, also comprising three dimensions (affective, continuity and regulatory, sociodemographic consideration of workers' organizations Rioverde, S.L.P. It is a descriptive, correlational, cross focusing addition to quantitative research, statistical techniques were used Pearson's r, Spearman Rho, a single factor ANOVA for independent samples t. The sample was made up of 196 workers from different organizations Rioverde SLP, self-administered survey was implemented using the instrument of the questionnaire consists of 30 variables, divided into 12 variables to measure job satisfaction and 18 variables to measure organizational commitment, and type 7 sociodemographic variables. The results show that the correlation between job satisfaction and organizational commitment, as well as sociodemographic variables influence organizational commitment.

  3. Analysis of the moments of the sensitivity function for resistivity over a homogeneous half-space: Rules of thumb for pseudoposition, offline sensitivity and resolution

    Science.gov (United States)

    Butler, S. L.

    2017-08-01

    It is instructive to consider the sensitivity function for a homogeneous half space for resistivity since it has a simple mathematical formula and it does not require a priori knowledge of the resistivity of the ground. Past analyses of this function have allowed visualization of the regions that contribute most to apparent resistivity measurements with given array configurations. The horizontally integrated form of this equation gives the sensitivity function for an infinitesimally thick horizontal slab with a small resistivity contrast and analysis of this function has admitted estimates of the depth of investigation for a given electrode array. Recently, it has been shown that the average of the vertical coordinate over this function yields a simple formula that can be used to estimate the depth of investigation. The sensitivity function for a vertical inline slab has also been previously calculated. In this contribution, I show that the sensitivity function for a homogeneous half-space can also be integrated so as to give sensitivity functions to semi-infinite vertical slabs that are perpendicular to the array axis. These horizontal sensitivity functions can, in turn, be integrated over the spatial coordinates to give the mean horizontal positions of the sensitivity functions. The mean horizontal positions give estimates for the centres of the regions that affect apparent resistivity measurements for arbitrary array configuration and can be used as horizontal positions when plotting pseudosections even for non-collinear arrays. The mean of the horizontal coordinate that is perpendicular to a collinear array also gives a simple formula for estimating the distance over which offline resistivity anomalies will have a significant effect. The root mean square (rms) widths of the sensitivity functions are also calculated in each of the coordinate directions as an estimate of the inverse of the resolution of a given array. For depth and in the direction perpendicular

  4. Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells.

    Science.gov (United States)

    Fukuda, Mitsunori

    2003-04-25

    Slp4-a (synaptotagmin-like protein 4-a)/granuphilin-a is specifically localized on dense-core vesicles in PC12 cells and negatively controls dense-core vesicle exocytosis through specific interaction with Rab27A via the N-terminal Slp homology domain (SHD) (Fukuda, M., Kanno, E., Saegusa, C., Ogata, Y., and Kuroda, T. S. (2002) J. Biol. Chem. 277, 39673-39678). However, the mechanism of the inhibition by Slp4-a has never been elucidated at the molecular level and is still a matter of controversy. In this study, I discovered an unexpected biochemical property of Slp4-a, that Slp4-a, but not other Rab27 effectors reported thus far, is capable of interacting with both Rab27A(T23N), a dominant negative form that mimics the GDP-bound form, and Rab27A(Q78L), a dominant active form that mimics the GTP-bound form, whereas Slp4-a specifically recognizes the GTP-bound form of Rab3A and Rab8A and does not recognize their GDP-bound form. I show by deletion and mutation analyses that the TGDWFY sequence in SHD2 is essential for Rab27A(T23N) binding, whereas SHD1 is involved in Rab27A(Q78L) binding. I further show by immunoprecipitation and cotransfection assays that Munc18-1, but not syntaxin IA, directly interacts with the C-terminal domain of Slp4-a in a Rab27A-independent manner. Expression of Slp4-a mutants that lack Rab27A(T23N) binding activity (i.e. specific binding to Rab27A(Q78L)) completely reverses the inhibitory effect of the wild-type Slp4-a on high KCl-dependent neuropeptide Y secretion in PC12 cells. The results strongly indicate that interaction of Slp4-a with the GDP-bound form of Rab27A, not with syntaxin IA or Munc18-1, is the primary reason that Slp4-a expression inhibits dense core vesicle exocytosis in PC12 cells.

  5. Effect of Corrugation and Reinforcement on the Dispersion of SH-wave Propagation in Corrugated Poroelastic Layer Lying over a Fibre-reinforced Half-space

    Science.gov (United States)

    Singh, Abhishek Kumar; Das, Amrita; Lakshman, Anirban; Chattopadhyay, Amares

    2016-10-01

    The presence of porosity and reinforcement in a medium is an important factor affecting seismic wave propagation and plays vital role in many geophysical prospects. Also, the presence of salt and ore deposits, mountains, basins, mountain roots, etc. is responsible for the existence of corrugated boundary surfaces of constituent layers. Such facts brought motivation for the present paper which deals with the propagation of SH-wave in a heterogeneous fluid-saturated poroelastic layer with corrugated boundaries lying over an initially stressed fibre-reinforced elastic halfspace. Closed form of dispersion relation has been obtained and is found in well agreement to classical Love wave equation for isotropic case. The effect of corrugation, wave number, undulation, position parameter, horizontal compressive/tensile initial stress and heterogeneity on phase velocity has been analysed through numerical computation and graphical illustration. Moreover, comparative study exploring the effect of presence and absence of reinforcement in half-space on dispersion curve is the major highlight of the current study.

  6. Diffraction of plane P waves by a canyon of arbitrary shape in poroelastic half-space (Ⅱ): Numerical results and discussion

    Institute of Scientific and Technical Information of China (English)

    Jianwen Liang; Zhongxian Liu

    2009-01-01

    This paper investigates in detail the nature of diffraction of plane P waves around a canyon in poroelastic half-space, and studies the effects of incident frequency, drainage condition, porosity, etc, on the diffraction of waves. It is shown that the surface displacement amplitudes of the drained case are close to those of the undrained case, however, the surface displacement amplitudes of the dry case are very different from those of the saturated (either drained or undrained) cases. There are large phase shift between the dry case and the saturated cases, as well as slightly longer resultant wavelengths for the undrained case than those for the drained case and longer resultant wavelengths for the drained case than those for the dry case. For small porosity the surface displacement amplitudes for the saturated cases are almost identical to those for the dry case; while for large porosity, the effect of drainage condition becomes significant, and the surface displacement amplitudes for the undrained case are larger than those for the drained case. As the incident frequency increases, the effect of porosity becomes significant, and more significant for the undrained case than that for the drained case. As the porosity increases, the pore pressures increase significantly but their oscillations become smoother. As the incident frequency increases, the pore pressures become more complicated.

  7. Effect of Corrugation and Reinforcement on the Dispersion of SH-wave Propagation in Corrugated Poroelastic Layer Lying over a Fibre-reinforced Half-space

    Directory of Open Access Journals (Sweden)

    Singh Abhishek Kumar

    2016-10-01

    Full Text Available The presence of porosity and reinforcement in a medium is an important factor affecting seismic wave propagation and plays vital role in many geophysical prospects. Also, the presence of salt and ore deposits, mountains, basins, mountain roots, etc. is responsible for the existence of corrugated boundary surfaces of constituent layers. Such facts brought motivation for the present paper which deals with the propagation of SH-wave in a heterogeneous fluid-saturated poroelastic layer with corrugated boundaries lying over an initially stressed fibre-reinforced elastic halfspace. Closed form of dispersion relation has been obtained and is found in well agreement to classical Love wave equation for isotropic case. The effect of corrugation, wave number, undulation, position parameter, horizontal compressive/tensile initial stress and heterogeneity on phase velocity has been analysed through numerical computation and graphical illustration. Moreover, comparative study exploring the effect of presence and absence of reinforcement in half-space on dispersion curve is the major highlight of the current study.

  8. Construction of sequences of exact analytical solutions for heat diffusion in graded heterogeneous materials by the Darboux transformation method. Examples for half-space

    Science.gov (United States)

    Krapez, J.-C.

    2016-09-01

    The Darboux transformation is a differential transformation which, like other related methods (supersymmetry quantum mechanics-SUSYQM, factorization method) allows generating sequences of solvable potentials for the stationary 1D Schrodinger equation. It was recently shown that the heat equation in graded heterogeneous media, after a Liouville transformation, reduces to a pair of Schrödinger equations sharing the same potential function, one for the transformed temperature and one for the square root of effusivity. Repeated joint PROperty and Field Darboux Transformations (PROFIDT method) then yield two sequences of solutions: one of new solvable effusivity profiles and one of the corresponding temperature fields. In this paper we present and discuss the outcome in the case of a graded half-space domain. The interest in this methodology is that it provides closed-form solutions based on elementary functions. They are thus easily amenable to an implementation in an inversion process aimed, for example, at retrieving a subsurface effusivity profile from a modulated or transient surface temperature measurement (photothermal characterization).

  9. EFFECT OF SURFACE ENERGY ON DISLOCATION-INDUCED FIELD IN HALF-SPACE WITH APPLICATION TO THIN FILM-SUBSTRATE SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    Ganyun Huang; Bob Svendsen; Zhixing Lu

    2009-01-01

    In this work the elastic field of an edge dislocation in a half-space with the effect of surface energy has been obtained. The elastic field is then used to study the image force on the dislocation, the critical thickness for dislocation generation in epitaxial thin films with strain mismatch and the yielding strength of thin films on substrates. The results show that the image forces on the dislocation deviate from the conventional solutions when the distance of the dislocation from the free surface is smaller than several times of the characteristic length. Also due to the effect of surface energy, the critical thickness for dislocation generation is smaller than that predicted by the conventional elastic solutions and the extent of the deviation depends on the magnitude of mismatch strain. In contrast, the effect of surface energy on the yielding strength for many practical thin films can be neglected except for some soft ones where the characteristic length is comparable to the thickness.

  10. Evaluating the Effectiveness of Conservation on Mangroves: A Remote Sensing-Based Comparison for Two Adjacent Protected Areas in Shenzhen and Hong Kong, China

    Directory of Open Access Journals (Sweden)

    Mingming Jia

    2016-07-01

    Full Text Available Mangroves are ecologically important ecosystems and globally protected. The purpose of this study was to evaluate the effectiveness of mangrove conservation efforts in two adjacent protected areas in China that were under the management policies of the Ramsar Convention (Mai Po Marshes Nature Reserve (MPMNR, Hong Kong and China’s National Nature Reserve System (Futian Mangrove National Nature Reserve (FMNNR, Shenzhen. To achieve this goal, eleven Landsat images were chosen and classified, areal extent and landscape metrics were then calculated. The results showed that: from 1973–2015, the areal extent of mangroves in both reserves increased, but the net change for the MPMNR (281.43 hm2 was much higher than those of the FMNNR (101.97 hm2. In general, the area-weighted centroid of the mangroves in FMNNR moved seaward by approximately 120 m, whereas in the MPMNR, the centroid moved seaward even farther (410 m. Although both reserves saw increased integrality and connectivity of the mangrove patches, the patches in the MPMNR always had higher integrality than those in the FMNNR. We concluded that the mangroves in the MPMNR were more effectively protected than those in the FMNNR. This study may provide assistance to the formulation of generally accepted criteria for remote sensing-based evaluation of conservation effectiveness, and may facilitate the development of appropriate mangrove forest conservation and management strategies in other counties.

  11. Precise method for Love surface waves in layered half-space%分层半空间中Love表面波的精细方法

    Institute of Scientific and Technical Information of China (English)

    高强; 钟万勰; 林家浩

    2006-01-01

    The PIM (precise integration method) is a precise method for solving the linear ODEs (ordinary differential equations) with two-point boundary value conditions or initial value conditions. The Love surface waves propagating in a transversely isotropic and layered half-space is studied by using the PIM and the extended Wittrick-Williams (W-W) algorithm. The solid is multi-layered and located above a semi-infinite space. The solution of Love surface waves is an eigenvalue problem of ODEs in the frequency-wavenumber domain. And by means of the eigenvalue counting technique, the extended W-W algorithm can be developed to find all eigenvalues without missing anyone. The method presented is exact in the sense so that it depends only on the precision of the computer used.%精细积分法是求解线性常微分方程两端边值问题和初值问题的精细算法.应用精细积分法(PIM)和扩展Wittrick-Williams(W-W)算法求解了横观各向同性、分层半空间中的Love表面波问题.岩层是由分层介质置于半无限空间上组成.Love表面波对应于波数-频率域线性常微分方程的本征值问题.利用本征值计数技术,扩展W-W算法可以不遗漏地找到所有本征值,得到计算机精度意义下的精确解.

  12. Two adjacent and similar TetR family transcriptional regulator genes, SAV577 and SAV576, co-regulate avermectin production in Streptomyces avermitilis.

    Science.gov (United States)

    Guo, Jia; Zhang, Xuan; Chen, Zhi; Wen, Ying; Li, Jilun

    2014-01-01

    Streptomyces avermitilis is an important bacterial species used for industrial production of avermectins, a family of broad-spectrum anthelmintic agents. We previously identified the protein SAV576, a TetR family transcriptional regulator (TFR), as a downregulator of avermectin biosynthesis that acts by controlling transcription of its major target gene SAV575 (which encodes cytochrome P450/NADPH-ferrihemoprotein reductase) and ave genes. SAV577, another TFR gene, encodes a SAV577 protein that displays high amino acid homology with SAV576. In this study, we examined the effect of SAV577 on avermectin production and the relationships between SAV576 and SAV577. SAV577 downregulated avermectin biosynthesis indirectly, similarly to SAV576. SAV576 and SAV577 both directly repressed SAV575 transcription, and reciprocally repressed each other's expression. SAV575 transcription levels in various S. avermitilis strains were correlated with avermectin production levels. DNase I footprinting and electrophoretic mobility shift assays indicated that SAV576 and SAV577 compete for the same binding regions, and that DNA-binding affinity of SAV576 is much stronger than that of SAV577. GST pull-down assays revealed no direct interaction between the two proteins. Taken together, these findings suggest that SAV577 regulates avermectin production in S. avermitilis by a mechanism similar to that of SAV576, and that the role of SAV576 is dominant over that of SAV577. This is the first report of two adjacent and similar TFR genes that co-regulate antibiotic production in Streptomyces.

  13. Two adjacent and similar TetR family transcriptional regulator genes, SAV577 and SAV576, co-regulate avermectin production in Streptomyces avermitilis.

    Directory of Open Access Journals (Sweden)

    Jia Guo

    Full Text Available Streptomyces avermitilis is an important bacterial species used for industrial production of avermectins, a family of broad-spectrum anthelmintic agents. We previously identified the protein SAV576, a TetR family transcriptional regulator (TFR, as a downregulator of avermectin biosynthesis that acts by controlling transcription of its major target gene SAV575 (which encodes cytochrome P450/NADPH-ferrihemoprotein reductase and ave genes. SAV577, another TFR gene, encodes a SAV577 protein that displays high amino acid homology with SAV576. In this study, we examined the effect of SAV577 on avermectin production and the relationships between SAV576 and SAV577. SAV577 downregulated avermectin biosynthesis indirectly, similarly to SAV576. SAV576 and SAV577 both directly repressed SAV575 transcription, and reciprocally repressed each other's expression. SAV575 transcription levels in various S. avermitilis strains were correlated with avermectin production levels. DNase I footprinting and electrophoretic mobility shift assays indicated that SAV576 and SAV577 compete for the same binding regions, and that DNA-binding affinity of SAV576 is much stronger than that of SAV577. GST pull-down assays revealed no direct interaction between the two proteins. Taken together, these findings suggest that SAV577 regulates avermectin production in S. avermitilis by a mechanism similar to that of SAV576, and that the role of SAV576 is dominant over that of SAV577. This is the first report of two adjacent and similar TFR genes that co-regulate antibiotic production in Streptomyces.

  14. A Compression Method for ECG Based on DCT of Difference between Two Adjacent Frames%帧间差值的DCT压缩ECG数据的方法

    Institute of Scientific and Technical Information of China (English)

    王培康; 费小英

    2000-01-01

    心电图(ECG)信号具有准周期性,各个心动周期(称其为帧)的ECG波形极为相似,将相邻两帧的ECG波形数据相减,得到差值数据的波形比原始ECG波形平坦、数据值小,差值数据的DCT有效分量更为集中在低频段,且这些分量的幅度较低,由此,可以得到更高的数据压缩比。因此本文提出了一种利用ECG帧间差值代替原始ECG信号进行DCT变换,并用双码长编码方法对DCT分量进行编码的数据压缩方法。用该方法得到的重构ECG波形具有良好的保真度。%Since most of the DCT coefficients of an initial ECG signal are spread in low frequency,so is the energy of the signal, we can get a higher compression ratio (CR) by distributing DCT coefficients in a smaller region of low frequency and by degrading the amplitude of main DCT coefficients. ECG is a quasi-periodic signal with strong correlation between adjacent frames, so the difference sequence between them is more smooth and has lower amplitudes. Based on this property, a method of ECG data compression via DCT is presented in this paper, and it replaces the DCT coefficients of the original signal with the DCT coefficients of difference between two adjacent frames of the original signal and the DCT coefficients are encoded into two kinds of codes with different lengths. The quality of the reconstructed signal got by this way is high.

  15. Reform on the Course Design in Industrial Engineering Based on SLP%基于 SLP 法的工业工程课程设计改革研究

    Institute of Scientific and Technical Information of China (English)

    黄剑锋; 吴小东

    2013-01-01

    Industrial engineering curriculum design and other practice teaching links can not keep up the pace of construction disciplines, so it requires the curriculum design system reform with a combination of industrial engineering personnel training objectives. To avoid mutual segmentation and separation with industrial engineering curriculum design, this paper proposed the SLP method of Logistics Engineering curriculum design, integrated the curriculum design of other major courses of industrial engineering to build industrial engineering curriculum design system.%  工业工程课程设计等实践教学环节跟不上学科建设的步伐,需要结合工业工程人才培养目标对课程设计体系进行改革。为了避免工业工程专业课程设计的相互分割和脱节,提出了以《物流工程》SLP 法课程设计为基础进行课程设计改革,整合工业工程其它专业主干课程的课程设计,构建工业工程综合课程设计体系。

  16. SLP65 deficiency results in perpetual V(D)J recombinase activity in pre-B-lymphoblastic leukemia and B-cell lymphoma cells.

    Science.gov (United States)

    Sprangers, M; Feldhahn, N; Liedtke, S; Jumaa, H; Siebert, R; Müschen, M

    2006-08-24

    Perpetual V(D)J recombinase activity involving multiple DNA double-strand break events in B-cell lineage leukemia and lymphoma cells may introduce secondary genetic aberrations leading towards malignant progression. Here, we investigated defective negative feedback signaling through the (pre-) B-cell receptor as a possible reason for deregulated V(D)J recombinase activity in B-cell malignancy. On studying 28 cases of pre-B-lymphoblastic leukemia and 27 B-cell lymphomas, expression of the (pre-) B-cell receptor-related linker molecule SLP65 (SH2 domain-containing lymphocyte protein of 65 kDa) was found to be defective in seven and five cases, respectively. SLP65 deficiency correlates with RAG1/2 expression and unremitting V(H) gene rearrangement activity. Reconstitution of SLP65 expression in SLP65-deficient leukemia and lymphoma cells results in downregulation of RAG1/2 expression and prevents both de novo V(H)-DJ(H) rearrangements and secondary V(H) replacement. We conclude that iterative V(H) gene rearrangement represents a frequent feature in B-lymphoid malignancy, which can be attributed to SLP65 deficiency in many cases.

  17. The interplay between the Rab27A effectors Slp4-a and MyRIP controls hormone-evoked Weibel-Palade body exocytosis.

    Science.gov (United States)

    Bierings, Ruben; Hellen, Nicola; Kiskin, Nikolai; Knipe, Laura; Fonseca, Ana-Violeta; Patel, Bijal; Meli, Athina; Rose, Marlene; Hannah, Matthew J; Carter, Tom

    2012-09-27

    Weibel-Palade body (WPB) exocytosis underlies hormone-evoked VWF secretion from endothelial cells (ECs). We identify new endogenous components of the WPB: Rab3B, Rab3D, and the Rab27A/Rab3 effector Slp4-a (granuphilin), and determine their role in WPB exocytosis. We show that Rab3B, Rab3D, and Rab27A contribute to Slp4-a localization to WPBs. siRNA knockdown of Slp4-a, MyRIP, Rab3B, Rab3D, Rab27A, or Rab3B/Rab27A, or overexpression of EGFP-Slp4-a or EGFP-MyRIP showed that Slp4-a is a positive and MyRIP a negative regulator of WPB exocytosis and that Rab27A alone mediates these effects. We found that ECs maintain a constant amount of cellular Rab27A irrespective of the WPB pool size and that Rab27A (and Rab3s) cycle between WPBs and a cytosolic pool. The dynamic redistribution of Rab proteins markedly decreased the Rab27A concentration on individual WPBs with increasing WPB number per cell. Despite this, the probability of WPB release was independent of WPB pool size showing that WPB exocytosis is not determined simply by the absolute amount of Rab27A and its effectors on WPBs. Instead, we propose that the probability of release is determined by the fractional occupancy of WPB-Rab27A by Slp4-a and MyRIP, with the balance favoring exocytosis.

  18. Positive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T-lymphocyte adhesion mediated by integrin α4β1

    Science.gov (United States)

    Dios-Esponera, Ana; Isern de Val, Soledad; Sevilla-Movilla, Silvia; García-Verdugo, Rosa; García-Bernal, David; Arellano-Sánchez, Nohemí; Cabañas, Carlos; Teixidó, Joaquin

    2015-01-01

    Stimulation by chemokines of integrin α4β1–dependent T-lymphocyte adhesion is a crucial step for lymphocyte trafficking. The adaptor Vav1 is required for chemokine-activated T-cell adhesion mediated by α4β1. Conceivably, proteins associating with Vav1 could potentially modulate this adhesion. Correlating with activation by the chemokine CXCL12 of T-lymphocyte attachment to α4β1 ligands, a transient stimulation in the association of Vav1 with SLP-76, Pyk2, and ADAP was observed. Using T-cells depleted for SLP-76, ADAP, or Pyk2, or expressing Pyk2 kinase–inactive forms, we show that SLP-76 and ADAP stimulate chemokine-activated, α4β1-mediated adhesion, whereas Pyk2 opposes T-cell attachment. While CXCL12-promoted generation of high-affinity α4β1 is independent of SLP-76, ADAP, and Pyk2, the strength of α4β1-VCAM-1 interaction and cell spreading on VCAM-1 are targets of regulation by these three proteins. GTPase assays, expression of activated or dominant-negative Rac1, or combined ADAP and Pyk2 silencing indicated that Rac1 activation by CXCL12 is a common mediator response in SLP-76–, ADAP-, and Pyk2-regulated cell adhesion involving α4β1. Our data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and α4β1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation. PMID:26202465

  19. RELOCATION OF HOME APPLIANCES FACTORY BY USING SYSTEMATICAL LAYOUT PLANNING (SLP COMBINED WITH FLOW ANALYSIS AND ASSEMBLY PROCESS DESIGN

    Directory of Open Access Journals (Sweden)

    Yosef Adji Baskoro

    2011-12-01

    Full Text Available Every manufacturing company must have experiencing building a layout. Fred.E Meyers has stated that only death and taxes are certain, there exist a third certainty-a plant layout will change, thus many methods to generate layout are established and each has its own purposes and benefits. This research focused on the design of manufacturing facilities supported by in-depth analysis of Assembly process design with a high stresses on the Systematical Layout Planning ( SLP and Flow Analysis method to facilitate an outcome of layout accordingly to the system needs. This is a real case study conducts with an objective of generating a recommendation layout for Home Appliances Company specifically for television plant

  20. RELOCATION OF HOME APPLIANCES FACTORY BY USING SYSTEMATICAL LAYOUT PLANNING (SLP COMBINED WITH FLOW ANALYSIS AND ASSEMBLY PROCESS DESIGN

    Directory of Open Access Journals (Sweden)

    Yosef Adji Baskoro

    2011-12-01

    Full Text Available Every manufacturing company must have experiencing building a layout. Fred.E Meyers has stated that only death and taxes are certain, there exist a third certainty-a plant layout will change, thus many methods to generate layout are established and each has its own purposes and benefits. This research focused on the design of manufacturing facilities supported by in-depth analysis of Assembly process design with a high stresses on the Systematical Layout Planning ( SLP and Flow Analysis method to facilitate an outcome of layout accordingly to the system needs. This is a real case study conducts with an objective of generating a recommendation layout for Home Appliances Company specifically for television plant.

  1. A PLC-γ1 Feedback Pathway Regulates Lck Substrate Phosphorylation at the T-Cell Receptor and SLP-76 Complex.

    Science.gov (United States)

    Belmont, Judson; Gu, Tao; Mudd, Ashley; Salomon, Arthur R

    2017-08-04

    Phospholipase C gamma 1 (PLC-γ1) occupies a critically important position in the T-cell signaling pathway. While its functions as a regulator of both Ca(2+) signaling and PKC-family kinases are well characterized, PLC-γ1's role in the regulation of early T-cell receptor signaling events is incompletely understood. Activation of the T-cell receptor leads to the formation of a signalosome complex between SLP-76, LAT, PLC-γ1, Itk, and Vav1. Recent studies have revealed the existence of both positive and negative feedback pathways from SLP-76 to the apical kinase in the pathway, Lck. To determine if PLC-γ1 contributes to the regulation of these feedback networks, we performed a quantitative phosphoproteomic analysis of PLC-γ1-deficient T cells. These data revealed a previously unappreciated role for PLC-γ1 in the positive regulation of Zap-70 and T-cell receptor tyrosine phosphorylation. Conversely, PLC-γ1 negatively regulated the phosphorylation of SLP-76-associated proteins, including previously established Lck substrate phosphorylation sites within this complex. While the positive and negative regulatory phosphorylation sites on Lck were largely unchanged, Tyr(192) phosphorylation was elevated in Jgamma1. The data supports a model wherein Lck's targeting, but not its kinase activity, is altered by PLC-γ1, possibly through Lck Tyr(192) phosphorylation and increased association of the kinase with protein scaffolds SLP-76 and TSAd.

  2. Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells

    NARCIS (Netherlands)

    R. Kersseboom (Rogier); S. Middendorp; G.M. Dingjan (Gemma); K. Dahlenborg; M. Reth; H. Jumaa; R.W. Hendriks (Rudi)

    2003-01-01

    textabstractExpression of the pre-B cell receptor (pre-BCR) leads to activation of the adaptor molecule SLP-65 and the cytoplasmic kinase Btk. Mice deficient for one of these signaling proteins have an incomplete block in B cell development at the stage of large cycling

  3. The effect of VMP35 supplement ingredients encapsulated in a novel Phospholipid Prodosome SK713 SLP nutrient delivery technology on properties of live human blood.

    Directory of Open Access Journals (Sweden)

    Kenneth Blum

    2015-09-01

    Full Text Available Background: In North America digestive malfunction in terms of disintegration, dissolution, and absorption of food and nutrients, is a widespread malady. Malabsorption is also an exacerbating factor in most chronic degenerative diseases that might benefit from dietary supplementation. The purpose of this experiment was to determine, as shown by changes in properties of live blood, whether, a novel soy-lecithin-phospholipid-nutrient encapsulation technology could promote rapid bioavailability and bioactivity of a VMP35 nutraceutical formulation encapsulated within its clustoidal multilamellar Soy Lecithin Phospholipid (SLP liquid SK713 SLP structures. Method: Changes in peripheral blood smears from 38 subjects were measured utilizing peripheral live blood cell imaging (LBCI with phase contrast microscopy. Results: Compared to baseline and control, consistently and reproducibly, the SK713 SLP technology effected positive changes in the blood as demonstrated by observable morphological, hematological and rheological changes five minutes from intake and sustained for at least 30 minutes post intake. Conclusions: These results showed that the SK713 SLP system makes an important contribution by increasing the potential benefits of dietary supplementation to those patients with compromised digestive processes. We encourage additional research on this novel delivery system believing that it has potential impact on future therapy.

  4. Spatio-temporal Variability of Northern Hemipheric Sea Level Pressure (SLP) and Precipitation overthe Mid-to-Low Reaches of the Yangtze River

    Institute of Scientific and Technical Information of China (English)

    HAN Xue; WEI Fengying; Yves M.TOURRE; DONG Wenjie

    2008-01-01

    The spatio-temporal variability of Northern Hemisphere Sea Level Pressure (SLP) and precipitation over the mid-to-low reaches of the Yangtze River (PMLY) is analyzed jointly using the multi-taper /singular value decomposition method (MTM-SVD). Statistically significant narrow frequency bands are obtained from the local fractional variance (LFV) spectrum. Significant interdecadal (i.e., 16-to-18-year periods) and interannual (i.e., 3-to-6-year periods) signals are identified. Moreover, a significant quasi-biennial signal is identified but only for PMLY data. The spatial joint evolution of patterns obtained for peaks in the LFV spectrum sheds light on relationships between SLP and PMLY: the Arctic Oscillation (AO) modulates the variability of the PMLY while the interannual variability of PMLY is in phase with the Northern Atlantic Oscillation (NAO) and the Northern Pacific Oscillation (NPO).

  5. Rearrangement of the layout of the welding equipment of a company in the metal mechanical sector using the Systematic Layout Planning method (SLP

    Directory of Open Access Journals (Sweden)

    Silvio Alexsandro Turati

    2016-06-01

    Full Text Available The correct physical layout is relevant to the operational efficiency of the company. This study proposes rearranging the layout of the welding equipment of a company in the metal mechanical sector, which is located in Araras/SP, aiming to improve the production workflow. The Systematic Layout Planning method (SLP was used, with the field research divided into steps: obtaining detailed information about the process and the product; meetings with stakeholders; determining inter-related activities; analyzing space requirements; developing a new layout. The new layout has space allocated for the purchasing of new machinery, the existing machinery has been redistributed by specialty, and the unloading of raw materials has been transferred to the shed, maximizing the use of overhead cranes and keeping the stock close to the warehouse. In addition, forklift traffic flow has decreased; new movement corridors were demarcated; and painting areas were isolated. In conclusion, the SLP method proved efficient in creating a layout.

  6. PICASSO-SLP: a Langmuir probe instrument for monitoring the upper ionosphere on board a pico-satellite

    Science.gov (United States)

    Ranvier, Sylvain; Anciaux, Michel; Cardoen, Pepijn; Gamby, Emmanuel; Bonnewijn, Sabrina; De Keyser, Johan; Echim, Marius; Pieroux, Didier

    2016-04-01

    A novel Langmuir probe instrument, which will fly on board the Pico-Satellite for Atmospheric and Space Science Observations (PICASSO), is under development at the Royal Belgian Institute for Space Aeronomy. PICASSO, an ESA in-orbit demonstrator, is a triple unit CubeSat of dimensions 340.5x100x100 mm. The sweeping Langmuir probe (SLP) instrument, which includes four thin cylindrical probes whose electrical potential is swept, is designed to measure both plasma density and electron temperature at an altitude varying from about 400 km up to 700 km from a high inclination orbit. Therefore, the plasma density is expected to fluctuate over a wide range, from about 1e8/m³ at high latitude and high altitude up to several times 1e12/m³ at low/mid latitude and low altitude. The electron temperature is expected to lie between approximately 1.000 K and 10.000 K. Given the high inclination of the orbit, the SLP instrument will allow a global monitoring of the ionosphere with a maximum spatial resolution of the order of 150 m for the electron density and temperature, and up to a few meters for electron density only. The main goals are to study 1) the ionosphere-plasmasphere coupling, 2) the subauroral ionosphere and corresponding magnetospheric features, 3) auroral structures, 4) polar caps, 5) for the density, the multi-scale behaviour, spectral properties and turbulence of processes typical for the auroral regions, and 6) ionospheric dynamics via coordinated observations with EISCAT's heating radar. Along the orbit, the Debye length is expected to vary from a few millimetres up to a few meters. Due to the tight constraints in terms of mass and volume inherent to pico-satellites, the use of long booms, which would guarantee that the probes are outside the sheath of the spacecraft (several Debye lengths away), is not possible. Consequently, the probes might be in the sheath of the spacecraft in polar regions. Extensive modelling and simulations of the sheath effects on the

  7. Analysis of self-assembly of S-layer protein slp-B53 from Lysinibacillus sphaericus.

    Science.gov (United States)

    Liu, Jun; Falke, Sven; Drobot, Bjoern; Oberthuer, Dominik; Kikhney, Alexey; Guenther, Tobias; Fahmy, Karim; Svergun, Dmitri; Betzel, Christian; Raff, Johannes

    2017-01-01

    The formation of stable and functional surface layers (S-layers) via self-assembly of surface-layer proteins on the cell surface is a dynamic and complex process. S-layers facilitate a number of important biological functions, e.g., providing protection and mediating selective exchange of molecules and thereby functioning as molecular sieves. Furthermore, S-layers selectively bind several metal ions including uranium, palladium, gold, and europium, some of them with high affinity. Most current research on surface layers focuses on investigating crystalline arrays of protein subunits in Archaea and bacteria. In this work, several complementary analytical techniques and methods have been applied to examine structure-function relationships and dynamics for assembly of S-layer protein slp-B53 from Lysinibacillus sphaericus: (1) The secondary structure of the S-layer protein was analyzed by circular dichroism spectroscopy; (2) Small-angle X-ray scattering was applied to gain insights into the three-dimensional structure in solution; (3) The interaction with bivalent cations was followed by differential scanning calorimetry; (4) The dynamics and time-dependent assembly of S-layers were followed by applying dynamic light scattering; (5) The two-dimensional structure of the paracrystalline S-layer lattice was examined by atomic force microscopy. The data obtained provide essential structural insights into the mechanism of S-layer self-assembly, particularly with respect to binding of bivalent cations, i.e., Mg(2+) and Ca(2+). Furthermore, the results obtained highlight potential applications of S-layers in the fields of micromaterials and nanobiotechnology by providing engineered or individual symmetric thin protein layers, e.g., for protective, antimicrobial, or otherwise functionalized surfaces.

  8. Influence of initial stress, irregularity and heterogeneity on Love-type wave propagation in double pre-stressed irregular layers lying over a pre-stressed half-space

    Indian Academy of Sciences (India)

    Abhishek Kumar Singh; Amrita Das; Zeenat Parween; Amares Chattopadhyay

    2015-10-01

    The present paper deals with the propagation of Love-type wave in an initially stressed irregular vertically heterogeneous layer lying over an initially stressed isotropic layer and an initially stressed isotropic half-space. Two different types of irregularities, viz., rectangular and parabolic, are considered at the interface of uppermost initially stressed heterogeneous layer and intermediate initially stressed isotropic layer. Dispersion equations are obtained in closed form for both cases of irregularities, distinctly. The effect of size and shape of irregularity, horizontal compressive initial stress, horizontal tensile initial stress, heterogeneity of the uppermost layer and width ratio of the layers on phase velocity of Love-type wave are the major highlights of the study. Comparative study has been made to identify the effects of different shapes of irregularity, presence of heterogeneity and initial stresses. Numerical computations have been carried out and depicted by means of graphs for the present study.

  9. An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast.

    Science.gov (United States)

    Horikoshi, Yasunori; Habu, Toshiyuki; Matsumoto, Tomohiro

    2013-03-15

    For ordered mitotic progression, various proteins have to be regulated by an ubiquitin ligase, the anaphase-promoting complex or cyclosome (APC/C) with appropriate timing. Recent studies have implied that the activity of APC/C also contributes to release of mitotic checkpoint complexes (MCCs) from its target Cdc20 in the process of silencing the spindle assembly checkpoint (SAC). Here we describe a temperature-sensitive mutant (ubc11-P93L) in which cell cycle progression is arrested at mitosis. The mutant grows normally at the restrictive temperature when SAC is inactivated, suggesting that the arrest is not due to abnormal spindle assembly, but rather due to prolonged activation of SAC. Supporting this notion, MCCs remain bound to APC/C even when SAC is satisfied. The ubc11 (+) gene encodes one of the two E2 enzymes required for progression through mitosis in fission yeast. Remarkably, Slp1 (a fission yeast homolog of Cdc20), which is degraded in an APC/C-dependent manner, stays stable throughout the cell cycle in the ubc11-P93L mutant lacking the functional SAC. Other APC/C substrates, in contrast, were degraded on schedule. We have also found that a loss of Ubc4, the other E2 required for progression through mitosis, does not affect the stability of Slp1. We propose that each of the two E2 enzymes is responsible for collaborating with APC/C for a specific set of substrates, and that Ubc11 is responsible for regulating Slp1 with APC/C for silencing the SAC.

  10. Optimization Design of a Cafeteria Facilities Layout Based on SLP%基于SLP的某自助餐厅设施布局优化设计

    Institute of Scientific and Technical Information of China (English)

    周斌

    2014-01-01

    针对某自助餐厅的设施布局现状存在的诸多不合理问题,采用系统布置设计(SLP)方法对餐厅进行了物流和非物流关系分析,绘制出餐厅各作业单位位置相关图,根据相关图与餐厅的实际情况,对餐厅内各作业区进行优化设计,得到餐厅设施新的布局图.

  11. 基于SLP的铸钢厂物流设施布置设计%Layout Plan of Logistics Facilities of Steel Foundry Factories Based on SLP

    Institute of Scientific and Technical Information of China (English)

    姚会丽; 李冰

    2012-01-01

    In this paper, we analyzed the production process of cast steel products using the SLP method and provided a layout planning method based on job-unit logistics and non-logistics relational analysis. Then we planned the layout of the workshops, service and supporting departments and warehouses of the factory, derived the relational position chart of the logistics facilities of the factory and ultimately obtained the feasible general layout plan of the logistics facilitiesofthefactory.%采用系统化布置设计(SLP)方法通过分析铸件产品的生产流程,提供了一种以作业单位物流和非物流相关关系分析为基准的规划设计方法.同时对铸钢厂的生产车间、辅助服务部门、仓库进行设施布置设计,得出了该厂的物流设施位置相关图,并最终得到铸钢厂可行的物流设施总平面布置图.

  12. 基于SLP的智能医药仓库布局方法研究%Research of Intelligent Pharmaceutical Warehouse Layout Methods Based on SLP

    Institute of Scientific and Technical Information of China (English)

    李玉民; 张莉; 熊育伟

    2012-01-01

    为实现医药仓库的合理布局和智能管理,针对药品仓储的独特性提出了SLP方法下的智能医药仓库布局方法。首先采用系统化布置设计方法 SLP,从定性与定量相结合的角度对医药仓库进行了作业区域划分及平面布局设计;其次结合物联网技术,在上述布局的基础上进行了物联网设备布局分析,最后得出了基于SLP方法和物联网思想的智能医药仓库布局设计图。%To achieve the rational distribution and intelligent management of the pharmaceutical warehouse,given the special requirements during the drug storing,this paper proposed a intelligent pharmaceutical warehouse layout method based on SLP.First used System Layout Planning to analyze its operating regions and layout design from both qualitative and quantitative,based on the above,after analyzed the layout of the IOT equipment we reached a layout design of the intelligent pharmaceutical warehouse at the end.

  13. An integral-free expression for short-term changes in fault stability due to pore pressure induced when a point load is placed on the pervious boundary of a porous elastic half space containing a fault

    Indian Academy of Sciences (India)

    Ramesh Chander; S K Tomar

    2014-10-01

    A concentrated load with step-function time behaviour is placed normal to the planar, pervious boundary of a porous elastic half space (PEHS) with compressible constituents. A planar fault exists in the PEHS in such a way that the poroelastic behaviour of the medium is unhindered. We derive an approximate but integral-free expression for CFSCPP, i.e., changes in fault stability due to changes in pore pressure, at a point not too far off the line along which the load acts. But, in the interest of simplicity, the main discussion is focussed on a consideration of CFSCPP at a point located on the fault at depth directly beneath the load. It is convenient to introduce dimensionless time directly proportional to real time . The constant of proportionality is 4c/z2, where is hydraulic diffusivity. The derived approximate expression gives results with an accuracy of greater than 99% for limited values of after the load is imposed. We learn from the derived expression that, for a given , fault stability undergoes an initial sudden decrease commensurate with the undrained pore pressure induced in the PEHS. This is followed by a more gradual decrease in fault stability with increasing until a minimum is reached. The real time to minimum fault stability increases with . The magnitude of CFSCPP decreases with as −2 for a given in the permissible range. The derived expression and the inferences based on it should be useful during earth science investigations of the possible hazards due to reactivation of a pre-existing shallow fault when a civil engineering project involving imposition of a heavy load on the earth’s surface is to be executed nearby. They should be useful also for investigations if a shallow earthquake occurs near such a project soon after its execution.

  14. 静刚性分布脉冲荷载下弹性半空间表面竖向位移%VERTICAL SURFACE DISPLACEMENT OF AN ELASTIC HALF SPACE UNDER DYNAMIC LOADING OF STATIC RIGID DISTRIBUTION

    Institute of Scientific and Technical Information of China (English)

    付兵; 王振宇

    2009-01-01

    The main problem considered here is the transient response of an elastic half space under a dynamic impulse loading of static rigid distribution. By Laplace-Hankel transform to the goveming equations and boundary conditions, the solution of the basic equations is obtained in the integral transformation domain. Then the exact analytical solution for the vertical surface displacement of the ground is acquired applying inverse Laplace transform and Cagniard-De hoop method. The solution is composed of a number of different terms which represent P-wave, S-wave and R-wave contributions to the displacement. The paper has given the displacement-time curves of the location which is farther than the end of the radius of the area that the load acts on. The curves indicate that each stress wave arrives at the location two times successively with the process of time, and the location tends towards stillness then. The answer of the problem is at first in the history of elastodynamics and can be used to study the dynamic interaction and contact problems between soil and structures.%主要研究静刚性分布脉冲荷载作用下弹性半空间的瞬态响应.通过对控制方程和边界条件的Laplace-Hankel变换得到基本方程的积分变换解,然后应用Hankel逆变换和Cagniard-De hoop方法得到地基表面各点竖向位移的精确解析解.此解析解由代表P波、S波和R波对位移贡献的不同部分组成.该文给出了大于荷载作用面积的半径处的位移-时间曲线,曲线表明随着时间的推移,各应力波曾先后两次到达该处,然后该处逐渐趋于静止状态.此问题的求解从已有文献上来看尚数首次,可用于土与结构的动力相互作用和接触问题.

  15. 饱和半空间中隧道衬砌对平面SV波的散射IBIEM求解%IBIEM solution to scattering of plane SV waves by tunnel lining in saturated poroelastic half-space

    Institute of Scientific and Technical Information of China (English)

    刘中宪; 琚鑫; 梁建文

    2015-01-01

    基于Biot两相介质理论,采用一种高精度的间接边界积分方程法(IBIEM),研究了平面SV波在饱和半空间中隧道衬砌周围散射的基本规律,并给出了不同参数下地表位移幅值、衬砌动应力集中因子及表面孔隙水压分布图和相应的频谱结果.数值分析表明:饱和半空间隧道衬砌对SV波的散射特征取决于围岩介质孔隙率、入射波的频率和角度、隧道埋深等因素;隧道外壁透水状态对地表位移和隧道应力影响不大;不同角度SV波入射下,隧道应力集中部位有很大差别,且随半空间介质孔隙率增大,应力集中越发显著;衬砌外壁孔隙水压峰值可达到入射波应力幅值的4倍,且 30°斜入射下幅值明显大于 0°垂直入射情况;衬砌上方附近不同点位位移频谱特征差异显著,斜入射情况位移放大效应明显;随埋深增大,地表位移幅值和衬砌表面动应力谱振荡更为剧烈,但幅值会有所降低.另外,按波速比等效的单相介质模型可以近似计算SV波入射下隧道-饱和围岩的位移场和应力场.%Based on the Biot's theory of two-phase medium, a high-precision indirect boundary integral equation method (IBIEM) is proposed to solve the scattering of SV waves by a two-dimensional tunnel lining in saturated poroelastic half-space. The ground displacement amplitudes, dynamic stress concentration of the tunnel and pore pressure on the outer surface of the tunnel are investigated under different circumstances, and the frequency spectrum analysis is also made. Numerical analysis shows that the propagation and scattering characteristics of seismic waves depend on the porosity of the surrounding medium, frequency and angle of the incident waves, tunnel depth, etc. The drainage state of tunnel outer surface has little impact on the ground displacement amplitudes and dynamic stress concentration of the tunnel. The features of the dynamic stress concentration in the tunnel strongly

  16. 正交各向异性弹性层/功能梯度压电半空间结构中Love波的传播%Propagation of Love Waves in the Orthotropic Layer/Functionally Graded Piezoelectric Half-Space

    Institute of Scientific and Technical Information of China (English)

    孔艳平; 陈长虹; 刘金喜

    2013-01-01

    This paper investigated Love waves propagating in the layered half-space structure consisting of an orthotropic layer and a functionally graded piezoelectric half-space. The interface conditions of the layered half-space structure are perfect and imperfect. The material properties of the piezoelectric half-spaces vary exponentially in the direction perpendicular to the interfaces. Based on the dispersion equations, the numerical examples were presented to show the effects of variations of material properties, the cut angle of the orthotropic material and combined effects of the imperfect interface on the phase velocity. The obtained results are useful for the application of functionally graded piezoelectric materials to acoustic wave devices such as plate resonators, filters and sensors.%研究了功能梯度压电半空间上覆盖一层正交各向异性弹性层结构中Love波的传播特性.覆盖层与基底的界面连接方式分别考虑了理想接触和非理想接触2种模式,功能梯度压电半空间的材料性能沿垂直于界面方向以指数函数形式变化.基于推导的频散方程,结合数值算例分析了材料性能梯度变化、正交各向异性材料的切割角度和非理想界面的连接程度对相速度的影响,其结果对功能梯度压电材料的覆层结构在声波器件中的应用具有重要的参考价值.

  17. Implementation of SLP-based Security Service Discovery System%基于SLP安全服务发现系统的实现

    Institute of Scientific and Technical Information of China (English)

    沈仲针; 黄元元

    2009-01-01

    With the network services and users increasing, service discovery as intermediary between service providers and users is increasingly becoming one of the main studies of network services. This paper introduces a secure service discovery architecture, focusing on how to build an agreement based on the SLP to provide services for registration and inquiry mechanism, and certification center KDC as to achieve the certification service to ensure service reliability.%随着网络中服务和用户数目的增长,服务发现作为服务提供者和用户之间的中介,日益成为网络服务的主要研究方向之一.本文介绍了一种安全的服务发现架构,着重构建如何基于SLP协议提供服务的注册与查询机制,利用KDC作为认证中心实现服务的认证,保证服务的可靠性.

  18. Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast

    Science.gov (United States)

    Kimata, Yuu; Kitamura, Kenji; Fenner, Nicola; Yamano, Hiroyuki

    2011-01-01

    Meiosis is a specialized form of cell division generating haploid gametes and is dependent upon protein ubiquitylation by the anaphase-promoting complex/cyclosome (APC/C). Accurate control of the APC/C during meiosis is important in all eukaryotic cells and is in part regulated by the association of coactivators and inhibitors. We previously showed that the fission yeast meiosis-specific protein Mes1 binds to a coactivator and inhibits APC/C; however, regulation of the Mes1-mediated APC/C inhibition remains elusive. Here we show how Mes1 distinctively regulates different forms of the APC/C. We study all the coactivators present in the yeast genome and find that only Slp1/Cdc20 is essential for meiosis I progression. However, Fzr1/Mfr1 is a critical target for Mes1 inhibition because fzr1Δ completely rescues the defect on the meiosis II entry in mes1Δ cells. Furthermore, cell-free studies suggest that Mes1 behaves as a pseudosubstrate for Fzr1/Mfr1 but works as a competitive substrate for Slp1. Intriguingly, mutations in the D-box or KEN-box of Mes1 increase its recognition as a substrate by Fzr1, but not by Slp1. Thus Mes1 interacts with two coactivators in a different way to control the activity of the APC/C required for the meiosis I/meiosis II transition. PMID:21389117

  19. 基于动态仿真的改进SLP方法及在武汉卷烟库的应用%Improved SLP Method Based on Dynamic Simulation and Its Application in Wuhan Cigarette Warehouse

    Institute of Scientific and Technical Information of China (English)

    李乐

    2011-01-01

    将动态仿真技术与系统设施布局设计方法相结合,提出了面向对象仿真优化的改进SLP方法.以静态工艺过程、物流流程数据为基础,建立动态仿真模型计算不同条件下各种布局方案的物流运行效率和运行成本.采用改进的SLP方法对武汉卷烟厂外运仓库系统进行的科学规划设计.系统运行结果表明,作业流程顺畅平衡、物流作业效率得到有效提高.%Through combining the dynamic simulation technology with system layout planning (SLP), the paper proposes an improved SLP method based on object-oriented simulation and sets up a dynamic simulation model to calculate the logistics efficiency and cost of different layouts under different conditions. Then the improved SLP method is applied to the outbound warehouse system of Wuhan tobacco factory and yields result demonstrating more smooth operational process and higher logistics efficiency.

  20. Global Layout Design for Iron and Steel Plants Based on SLP%基于SLP的钢铁厂总体布局设计

    Institute of Scientific and Technical Information of China (English)

    周尔民; 陈科楼

    2011-01-01

    In this paper, layout design is addressed for iron and steel plant such that the general design re-quirements can be satisfied by using systematic layout planning ( SLP) method. According to the produc-tion process for the entire plant, the material flow relation is determined among the main facilities including the production workshops, auxiliary plants, power plants, transportation fields, the administrative depart-ments, and subsidiary production and living services departments. With these data, aggregate layout de-sign is obtained. Then, detailed layout is designed based on the space required for each facility. It shows that the design obtained can save space, reduce production cost, and increase productivity.%以钢铁厂总生产工艺流程为基础,按主要作业单元的总体设计要求,对钢铁厂主要作业场地的总体布置关系予以确定。依据生产车间、辅助车间、动力车间、交通运输设施、职能部门、附属生产和生活服务等部门之间的内外关联、物料进出状况,进行系统优化布置设计。再由各个作业单位的面积大小、位置关系,适当参考其他限制条件和常识惯例,做出钢铁厂总体布局设计,达到布局科学、节约资源、产能提升的效果。

  1. 含有半圆环形衬砌的弹性半空间受线源荷载作用的位移场%DISPLACEMENT FIELD OF THE ELASTIC HALF SPACE WITH A HALF CIRCULAR LINING WHILE BEARING LINE LOAD HORIZONTAL SPACE

    Institute of Scientific and Technical Information of China (English)

    齐辉; 刘殿魁; 史守峡

    2001-01-01

    研究含有半圆环形衬砌的弹性半空间受一线源荷载作用时位移场的解答.给出了含有半圆环形衬砌的弹性空间在其水平表面任意一点承受时间谐和的出平面线源荷载作用时位移场的解答,分析了该位移场的性质.为采用Green函数方法并利用契合方法研究界面圆环形衬砌周边动应力集中问题奠定了基础.%Studies the solution to the displacement field with the elastic half space under the action of a half circular lining to give the essential solution to the displacement filed with an elastic half space under the action of a half circular lining while the bearing out-plane harmonic line load in the horizontal surface and analyses the nature of the displacement field,thereby providing basis for use of the Green's function to study the dynamic concentration on interface circular lining.

  2. Three-dimensional scattering of obliquely incident plane SH waves in alluvial valley embedded in layered saturated half-space%斜入射平面SH波在层状饱和半空间中沉积谷地周围的三维散射

    Institute of Scientific and Technical Information of China (English)

    巴振宁; 梁建文; 梅雄一

    2013-01-01

    The indirect boundary element method (IBEM) is proposed to study the three-dimensional scattering problem by a two-dimensional valley embedded in a fluid-saturated, poroelastic layered half-space for obliquely incident seismic waves. The wave-number transform is applied in the axial direction of the valley to reduce the three-dimensional problem to a two-dimensional plane strain problem. Then the dynamic problem is solved in one section perpendicular to the axis of the valley, and finally the three-dimensional responses of the valley and of the layered site are obtained through the inverse wave-number expansion. The validity of the method is confirmed by comparison with the results of the corresponding dry poroelastic case, and numerical calculation and analyses are performed by taking the amplification of obliquely incident plane waves by an alluvial valley in a uniformly saturated poroelastic half space and in a single saturated poroelastic soil layer overlying on elastic bedrock as examples. The results show that the three-dimensional responses are distinctively different from the two-dimensional responses, that the surface displacement amplitudes near the valley in dry poroelastic and saturated poroelastic half-spaces are very different, and that the displacement amplitudes around the valley in a uniform saturated poroelastic half space are obviously different from those in a saturated, poroelastic layered half-space.%为研究层状饱和场地中沉积谷地对斜入射地震波的三维散射问题,建立了求解问题的2.5维间接边界元方法.通过沿沉积谷地轴线方向的傅里叶变换将三维问题降为二维问题,进而在沉积谷地的截面内进行边界单元的离散和求解,求得沉积谷地截面内的动力响应,然后再将截面内计算结果沿沉积谷地轴线方向进行波数展开即可求得任意位置动力响应.通过与弹性情况的比较验证了方法的正确性,并以均匀饱和半空间和基岩上单

  3. Indirect boundary integral equation method for solving scattering of seismic waves by an alluvial valley in fluid poroelastic layered half-space%流体饱和层状半空间中沉积谷地对地震波的散射-IBIEM求解

    Institute of Scientific and Technical Information of China (English)

    刘中宪; 梁建文; 赵瑞斌

    2013-01-01

    A new indirect boundary integral equation method for numerically solving the scattering of seismic waves by a two-dimensional alluvial valley of arbitrary shape in poroelastic layered half-space is proposed based on the single layer potential approach. The Green's functions of compressional and shear wave sources in poroelastic layered half-space are derived firstly, then the scattered waves in alluvial valley and layered half-space are constructed by using the fictitious wave sources close to the interface between the valley and the half-space respectively, and the magnitude of the fictitious wave sources is determined through continuous boundary conditions, and the total response can be obtained by the superposition of the free field and the scattered field. The precision of the proposed method is verified by the satisfaction extent of boundary conditions and the comparison between the degenerated solutions of single-phased half-space and the well-known solutions. The diffraction of plane SV waves around an alluvial valley in poroelastic layered half-space is studied with a typical example. It is illustrated that there exists significant difference between the scattering of waves around the poroelastic alluvial valley and the dry soil valley, and the drainage condition has large impact on earthquake ground motion in the valley. The wave scattering in layered sites and that in homogenous half-space are different in nature, and the total response characteristics combine the resonant behavior of the soil layers and the characteristics of scattering waves around the alluvial valley. Hence, to simulate the propagation of seismic waves more accurately, it is necessary to consider the multi-phased and layered characteristics of soil medium in reality.%针对流体饱和层状半空间中任意形状沉积谷地对地震波的散射问题,基于单层位势理论,建立一种新的间接边界积分方程法(IBIEM):首先推导饱和层状半空间中两类膨胀波

  4. Traslape espacial de la comunidad de peces dulceacuícolas diurnos en el sistema de humedal Media Luna, Rioverde, S.L.P., México Spatial overlap of the diurnal freshwater fish community in the Media Luna wetland system, Rioverde, S.L.P., Mexico

    Directory of Open Access Journals (Sweden)

    Jorge Palacio-Núñez

    2010-04-01

    Full Text Available El humedal de la Media Luna es el más representativo y el más presionado por uso turístico y acciones de manejo en la Llanura de Rioverde, S.L.P. Contiene 13 especies de peces, dos nocturnas y 11 diurnas. Estas últimas fueron consideradas en este estudio, entre las que destacan cinco especies endémicas de la zona, una especie nativa de amplia distribución y cinco introducidas. Con la finalidad de determinar el grado de traslape espacial entre las especies, se tomaron los datos de cinco momentos de muestreo efectuados entre 1998 y 1999, con n = 54 transectos subacuáticos en cada muestreo. Se analizó tanto la distribución poblacional de los peces por clase de edad (adultos, juveniles y crías, como la similitud entre pares de especies para las variables del hábitat: sector, profundidad y vegetación. Los peces adultos y juveniles tendieron a traslaparse; las crías se segregaron en sector y se traslaparon en profundidad y vegetación. Hubo traslape considerable entre especies nativas e introducidas en al menos un estadio de vida; la especie endémica con mayor grado de superposición espacial con los introducidos fue Ataeniobius toweri, mientras que la especie introducida que mayor traslape con las nativas fue Oreochromis sp. Todas las especies endemícos se encontraron en riesgo de extinción, por lo que se considera de especial interés la posible afectación por el traslape espacial con las especies introducidas.The Media Luna wetland is the most representative and most affected by tourism and management actions in the Llanura de Rioverde, S.L.P. It contains 13 fish species, two of them are nocturnal and eleven diurnal. This study considers only the diurnal species. From these, the most relevant are five local endemic, one native widely distributed and five introduced species. In order to determine the degree of spatial overlap, 54 sub-aquatic transects per sampling session were conducted from 1998 and 1999. The fish population

  5. Sulcus formation in a compressed elastic half space

    Science.gov (United States)

    Biggins, John; Mahadevan, L.

    2012-02-01

    When a block of rubber, biological tissue or other soft material is subject to substantial compression, its surfaces undergo a folding instability. Rather than having a smooth profile, these folds contain cusps and hence have been called creases or sulcii rather than wrinkles. The stability of a compressed surface was first investigated by Biot (1965), assuming the strains associated with the instability were small. However, the compression threshold predicted with this approach is substantially too high. I will introduce a family of analytic area preserving maps that contain cusps (and hence points of infinite strain) that save energy before the linear stability threshold even at vanishing amplitude. This establishes that there is a region before the linear stability threshold is reached where the system is unstable to infinitesimal perturbations, but that this instability is quintessentially non-linear and cannot be found with linear strain elasticity.

  6. 炭疽芽胞杆菌假想S-层蛋白SLP缺失突变体的构建%Construction of Putative S-Layer Protein SLP Deletion Mutant in Bacillus anthracis

    Institute of Scientific and Technical Information of China (English)

    唐恒明; 刘先凯; 高美琴; 冯尔玲; 朱力; 史兆兴; 廖祥儒; 王恒樑

    2009-01-01

    目的:构建炭疽芽胞杆菌假想S-层蛋白SLP缺失突变体,以进行后续SLP的功能研究,为炭疽芽孢杆菌重要基因功能的研究建立技术平台.方法:利用PCR技术,分别扩增得到目的基因的上游同源臂(slp-F)和下游同源臂(slp-R),将抗性基因(S)和上、下游同源臂先后连入穿梭质粒pKSV7,构建打靶载体pKSV7-FSR,经去甲基化后,电转化入炭疽芽胞杆菌A16R,通过同源重组敲除slp基因,并通过DNA测序和Western blot实验验证;对野生株和突变株37℃时的生长曲线及生化反应进行比较研究.结果:分别从DNA水平和蛋白质水平证实slp基因被成功敲除;突变株对数期生长较快,衰退较慢,与野生株的生化反应差异不明显.结论:获得了炭疽芽胞杆菌假想S-层蛋白SLP缺失突变体.

  7. 非理想界面正交各向异性层/压电半空间结构中Love波传播特性%Propagation behavior of love waves in an orthotropic layer/piezoelectric half-space with an imperfect interface

    Institute of Scientific and Technical Information of China (English)

    王艳红; 兰姣霞; 刘金喜

    2012-01-01

    The propagation behavior of love waves was investigated in a layered half-space structure with an imperfect interface. The structure consisted of an orthotropic elastic layer and a piezoelectric half-space. The imperfect level of the interface was described with a shear-lag model. The surface of the orthotropic layer was assumed to be mechanically free. The wave equations of the piezoelectric material and the orthotropic material were solved firstly, and then, the dispersion equation was derived in an explicit function form with boundary conditions and interface conditions. The numerical examples were provided to show the combined effects of imperfect interface, orthotropic level and material properties of piezoelectric layer on the dispersion characteristics. The results showed that the velocity of love waves decreases with wakening of interface constraint intensity; the orthotropic level and the piezoelectric constants have little effect on the velocity of love waves when the interface is highly imperfect.%研究了正交各向异性层与压电半空间非理想连接时Love波的传播特性.其中,界面条件由剪切滞后模型表征,正交各向异性层表面机械自由.首先,对压电材料和正交各向异性材料的波动方程进行求解,然后利用界面条件和边界条件推导显函形式的频散方程,最后进行数值计算,分析界面性态、压电材料性能和正交各向异性程度对频散特性的影响.分析结果表明:Love波的传播速度随着界面约束强度的降低而减小;当不理想程度较高时,正交各向异性程度和压电材料性能对Love波的传播速度影响不大.

  8. 水平n层导电半空间中运动时谐垂直电偶极子的电磁场%EMF of time-harmonic VED moving in a horizontal n-layer conducting half-space

    Institute of Scientific and Technical Information of China (English)

    嵇斗; 朱武兵; 王向军

    2014-01-01

    Based on the MAXWELL equation of the time-harmonic elctromagnetic field(EM F) and the boundary condition of the n-layer linear homogenous conducting medium ,this paper offers a series of general expressions of magnetism vector for the time-harmonic vertical electric dipole (VED) .Accor-ding to the basic principle of the special theory of relativity and Lorentz transformation ,the EM F of the moving dipole which is embedded in the first layer of the conducting half-space is presented .These expressions are used to solve for the EM F of the two-layer model of air and seawater and of the three-layer model of air ,seawater and seabed respectively .The comparison with the related literature veri-fies the correctness of the expressions .%对于 n层线性、均匀、各向同性水平成层导电媒质半空间,根据时谐电磁场的麦克斯韦方程和电磁场相对性原理,利用多层介质边界条件,给出了匀速运动垂直时谐电偶极子的矢量磁位表达式以及有源层中偶极子产生的电磁场表达通式。利用所得到的表达通式,分别求解两层(空气-海水)模型和三层(空气-海水-海床)模型的电磁场,并与有关文献进行了比较分析,验证了所得表达式的正确性。

  9. Research on Optimization of Warehouse Layout Based on SLP Method:A Case Study of Warehouse Management Optimization of Company A%基于SLP方法的仓库布局优化研究--以A公司仓储管理优化为例

    Institute of Scientific and Technical Information of China (English)

    熊立华; 徐嘉

    2016-01-01

    In the case of warehouse management optimization of company A, this paper uses the SLP method to optimize the warehouse layout, optimal moving path, and shorten the transportation distance.%以A公司仓储部为例,运用SLP方法对仓库布局进行优化,优化搬运路径,缩短发货时的搬运距离。

  10. Comparision between single-level cervical corpectomy and two-level discectomy in two-adjacent-level cervical spondylotic myelopathy%相邻两节段脊髓型颈椎病前路不同术式的比较

    Institute of Scientific and Technical Information of China (English)

    贾小林; 谭祖键; 杨阜滨; 杨明; 万革

    2012-01-01

    [Objective] To compare the outcomes of patients treated with either anterior cervical corpectomy with fusion ( ACCF) or anterior cervical discectomy with fusion ( ACDF) for two - adjacent - level cervical spondylotic myelopathy. [ Methods ] The case histories of 67 patients underwent surgical treatment for two - adjacent - level cervical spondylotic myelopathy from June 2006 to March 2010 were retrospectively reviewed. There were 36 with a single -level corpectomy and 31 with a two -level ACDF. The following were analyzed: ( 1) perioperative parameters (hospital stays, bleeding amounts, operative times, complications) , (2) clinical parameters (Japanese Orthopedic Association scores, Visual Analog Scale scores for neck and arm pain) , and (3) radiologic parameters (sagittal alignment, cervical lordosis, total cervical range of motion, segmental range of motion, anterior and posterior body height for the fused levels, fusion rate) . [ Results ] The mean durations of follow - up were 28. 96 ± 13. 21 (ACCF) and 26. 81 ± 11. 02 (ACDF) months. Of these above parameters, operative time, bleeding amount and complication rates were significantly greater in the ACCF group, whereas postoperative cervical lordosis and segmental height were significantly lower in the ACCF group postoperatively. However, other parameters were not significantly different between the 2 groups. All radiologic parameters occurred significantly more during the first 6 weeks after surgery than after 6 weeks. The loss of posterior body height for the fused levels significantly progressed after 6 weeks in Group ACCF, with no differences in Group ACDF. [ Conclusion] Our data suggest that the two procedures yield comparable results in terms of clinical outcomes for two -adjacent - level cervical spondylotic myelopathy. However, ACDF was found to be superior to ACCF in terms of operation times, bleeding amounts, complication rates and some radiologic results. The decision to perform either ACCF or ACDF

  11. 轴对称热-力埋置载荷下半空间饱和孔隙介质的动力响应%Dynamic Response of Half-Space Saturated Porous Media Under Embedded Axisymmetric Thermo-Mechanical Loads

    Institute of Scientific and Technical Information of China (English)

    易平凡; 赵社戌

    2013-01-01

    Based on the modified Biofs thermo-elastic constitutive theory, the thermo-mechanical coupled dynamic governing equations for saturated porous materials were derived. As to the problem of the half-space porous media under embedded axisymmetric thermo - mechanical loads, the analytical responses were obtained by Hankel transformation and the differences caused by different surface thermal conditions were analysed. The numerical results by the inverse Hankel transformation indicate that the pore pressure appears negative while the normal stresses are positive in area over the loads embedded depth. At the embedded depth, the normal stresses increase dramatically. The pore pressure and the normal stresses decrease with the increase of depth in area under the embedded depth. The temperature has almost no effect on responses if there is no extra heat source. Value of the pore pressure for insulated boundary condition is less than that when the boundary surface is isothermal.%基于修正的Biot热弹性本构理论,得到了饱和多孔介质热-力耦合的动力学控制方程.针对半空间孔隙介质在内置简谐热-力轴对称载荷作用下的动力问题,利用Hankel变换获得了响应的解析表达式,并利用Han-kel逆变换进行数值求解,分析了埋置深度、表面热边界条件等对响应的影响规律.结果表明:孔隙水压力在载荷作用处上方有负压出现;环向、径向及竖向应力在载荷作用处发生突变,且在载荷作用处上方均出现拉应力;在载荷作用处下方,孔隙水压力及竖向、径向和环向应力均随着深度的增大而减小.当内置热载荷仅设置温差,而无外热源输入时,温差对孔隙介质中的响应几乎不产生影响.当孔隙介质表面绝热时,孔隙水压力小于表面等温情况下的值.

  12. SEISMIC RESPONSE ANALYSIS OF A STRAIGHT-WALL-TOP-ARCH TUNNEL IN HALF SPACE UNDER INCIDENT PLANE P WAVES%平面压缩波入射下弹性半空间中直墙拱形隧道地震响应分析

    Institute of Scientific and Technical Information of China (English)

    谷文科; 刘蕾; 刘中宪

    2016-01-01

    The seismic response analysis of a straight-wall-top-arch tunnel in elastic half-space under incident plane P waves was carried out by an indirect boundary integration equation method (IBIEM).Through parametric analysis, the effect of the incident waves and the lining on the scattering of the plane waves was discussed.It was shown that there was an obvious difference between the wave scattering around the lined tunnel and that of the circular tunnel. The dynamic response mainly depended on the incident angle, incident frequency and the embedment depth and thickness of the tunnel, etc.There was a significant amplification effect on the surface movement near the tunnel under incident plane P waves.Significant dynamic stress concentration was also observed on the bottom of the straight-wall-top-arch tunnel under incident wave of low frequency.%采用间接边界积分方程法( IBIEM),对压缩波( P波)入射下弹性半空间中直墙拱形隧道的地震响应进行分析。通过参数分析,讨论入射波特性和衬砌特性对平面波散射的影响规律。计算结果表明:直墙拱形衬砌洞室附近波的散射同圆形衬砌情况相比差异显著;动力反应特征主要依赖于波入射角、入射波频率、衬砌埋深和厚度等参数;P波入射下洞室附近地面运动放大效应十分明显;低频波入射下,直墙拱形衬砌底板处的动应力集中现象最为显著。

  13. Avaliação de Sistema de Leitura Portátil (SLP para baixa visão desenvolvido no Brasil Evaluation of System Portable Reading (SPR for low vision developed in Brazil

    Directory of Open Access Journals (Sweden)

    Vagner Rogério dos Santos

    2009-10-01

    Full Text Available OBJETIVO: A proposta deste estudo é avaliar a eficácia e eficiência em uma série de casos do protótipo de um equipamento nacional de magnificação para leitura. MÉTODOS: Participaram deste estudo 30 pacientes na faixa etária entre 9 e 80 anos (17 do sexo masculino. Foi desenvolvido um aparelho portátil, patenteado pela UNIFESP (PI#020050145260, com um sistema de captura de imagens acoplado a um monitor de 5,6 polegadas proporcionando um aumento de 15 X. Foram analisadas a eficácia da acuidade visual e a eficiência de leitura após a utilização do protótipo proposto. RESULTADOS: Seis pacientes (20% apresentaram AV 8M, 12 pacientes (40% apresentaram AV 6M, 7 pacientes (23,3% apresentaram 5 M, 5 pacientes (16,7% apresentaram 4M. A média de acuidade visual antes da utilização do SLP medida pela tabela LHNV-1 logMAR foi de 5,75M e após a utilização 100% dos pacientes atingiram a eficácia de AV J1. CONCLUSÃO: O protótipo do SLP mostrou-se um recurso alternativo no processo de inclusão social das pessoas com baixa visão com diferentes níveis de resíduo visual. Também pode proporcionar incentivo psicológico, permitir conforto, mobilidade e independência àqueles que necessitam de uma leitura mais prolongada e maior distância de trabalho.PURPOSE: The proposal of this study is to test and to validate as the effectiveness and efficiency in a series of cases the prototype of a national equipment of magnification to reading. METHODS: A recently developed of equipment of magnification (patent pending Brazilian Institutte of Industrial Property # 020050145260 was tested in a group of 30 patients (age range 9 to 80 years, 17 males. A portable apparatus was developed with a system of capture of images coupled with a 5,6 inch monitor, providing an increase of 15 X. The effectiveness of the visual acuity and the reading efficiency were analyzed after the use of the proposed prototype. RESULTS: Six patients (20% presented AV 8M, 12

  14. 基于SLP的广药配送中心区域布置研究%Study on Distribution Center Area Layout of Guangzhou Pharmaceutical Corporation Based on SLP

    Institute of Scientific and Technical Information of China (English)

    张海芳; 张昕

    2014-01-01

    With the rapid development of chain stores and distribution system of medicine industry, and the personalized needs of customers, many early constructed warehouses by medicine companies have been unable to meet the current demand, and logistics has become the decisive factor for this industry to expand the sales market, so a few large medicine companies set up their own large-scale logistics distribution center. Taking the distribution center of Guangzhou Pharmaceuticals Corporation as an example, this paper analyzes the company's daily operation and uses SLP for layout of the functional areas of the distribution center, and finally selects the optimal scheme from various layout schemes.%随着医药行业的连锁门店和经销体系的飞跃发展,以及顾客的个性化的需求,很多医药公司早期建设的仓库已不能满足现状需求,物流成为此行业拓展销售市场的决胜因素,所以几大医药公司建立了自己的大型物流配送中心。本文以广州医药有限公司的配送中心为例,通过分析该公司配送中心进行的日常运作,采用SLP方法对配送中心的各功能区域进行布置,最终从多种布置方案中选择最优方案。

  15. An overview of service lifetime prediction (SLP)

    Energy Technology Data Exchange (ETDEWEB)

    Jorgensen, G. [National Renewable Energy Laboratory, Golden, CO (United States)

    1995-11-01

    This report describes the need for service life prediction for photovoltaic cells and associated devices, coatings, and other related technologies. Information regarding outdoor exposure tests is given.

  16. Influence of bus stop with left-turn lines between two adjacent signalized intersections

    Science.gov (United States)

    Pang, Ming-Bao; Ye, Lan-Hang; Pei, Ya-Nan

    2016-08-01

    Based on the symmetric two-lane Nagel-Schreckenberg (STNS) model, a three-lane cellular automaton model between two intersections containing a bus stop with left-turning buses is established in which model the occurrences of vehicle accidents are taken into account. The characteristics of traffic flows with different ratios of left-turn lines are discussed via the simulation experiments. The results indicate that the left-turn lines have more negative effects on capacity, accident rate as well as delay if the stop is located close to the intersections, where the negative effect in a near-side stop is more severe than that in a far-side one. The range of appropriate position for a bus stop without the bottleneck effect becomes more and more narrow with the increase of the ratio of left-turn bus lines. When the inflow is small, a short signal cycle and a reasonable offset are beneficial. When the inflow reaches or exceeds the capacity, a longer signal cycle is helpful. But if the stop position is inappropriate, the increase of cycle fails in reducing the negative effect of left-turning buses and the effectiveness of offset is weakened. Project supported by the National Natural Science Foundation of China (Grant No. 50478088) and the Natural Science Foundation of Hebei Province, China (Grant No. E2015202266).

  17. Complete nucleotide sequences of two adjacent early vaccinia virus genes located within the inverted terminal repetition.

    Science.gov (United States)

    Venkatesan, S; Gershowitz, A; Moss, B

    1982-11-01

    The proximal part of the 10,000-base pair (bp) inverted terminal repetition of vaccinia virus DNA encodes at least three early mRNAs. A 2,236-bp segment of the repetition was sequenced to characterize two of the genes. This task was facilitated by constructing a series of recombinants containing overlapping deletions; oligonucleotide linkers with synthetic restriction sites provided points for radioactive labeling before sequencing by the chemical degradation method of Maxam and Gilbert (Methods Enzymol. 65:499-560, 1980). The ends of the transcripts were mapped by hybridizing labeled DNA fragments to early viral RNA and resolving nuclease S1-protected fragments in sequencing gels, by sequencing cDNA clones, and from the lengths of the RNAs. The nucleotide sequences for at least 60 bp upstream of both transcriptional initiation sites are more than 80% adenine . thymine rich and contain long runs of adenines and thymines with some homology to procaryotic and eucaryotic consensus sequences. The gene transcribed in the rightward direction encodes an RNA of approximately 530 nucleotides with a single open reading frame of 420 nucleotides. Preceding the first AUG, there is a heptanucleotide that can hybridize to the 3' end of 18S rRNA with only one mismatch. The derived amino acid sequence of the protein indicated a molecular weight of 15,500. The gene transcribed in the leftward direction encodes an RNA 1,000 to 1,100 nucleotides long with an open reading frame of 996 nucleotides and a leader sequence of only 5 to 6 nucleotides. The derived amino acid sequence of this protein indicated a molecular weight of 38,500. The 3' ends of the two transcripts were located within 100 bp of each other. Although there are adenine . thymine-rich clusters near the putative transcriptional termination sites, specific AATAAA polyadenylic acid signal sequences are absent.

  18. Moving heat source response in micropolar half-space with two-temperature theory

    Science.gov (United States)

    Shaw, Soumen; Mukhopadhyay, Basudeb

    2013-03-01

    The present paper deals with the moving heat source response in a homogeneous, isotropic, micropolar semi-infinite medium in the presence of a finite rotation about its axis. In this context, two-temperature generalized thermoelasticity theory has been considered. In order to obtain the physical aspects of displacement, microrotation, stress distribution and temperature changes, a complex quartic equation has been solved by employing Descartes' algorithm with the help of an irreducible Cardan's method. To illustrate the analytical developments, the numerical solutions have been carried out for aluminum-epoxy composite, and the variations in displacement, microrotation, stress distribution and temperature changes have been shown graphically. This work may find applications in geophysics.

  19. The field of the vertical electric dipole immersed in the heterogeneous half-space

    Science.gov (United States)

    Barsukov, P. O.; Fainberg, E. B.

    2014-07-01

    The field of the vertical electric dipole (VED) immersed in the heterogeneous conductive halfspace (sea) is analyzed in time domain. In the near field of the source, the amplitudes of the electric and magnetic components of the field are proportional to power 3/2 and power 5/2 of the conductivity of the medium, respectively. After termination of the transmitter pulse, all the VED components decay with time as ˜1/ t 5/2. The possibility of applying the VED field for estimating the electrical properties of the offshore geological sections is demonstrated.

  20. Electromagnetic diffraction by an impedance cylinder buried halfway between two half-spaces

    KAUST Repository

    Salem, Mohamed

    2011-08-01

    We consider the problem of electromagnetic diffraction from a cylinder with impedance surface and half-buried between two dielectric media. An arbitrary located electric dipole provides the excitation. The harmonic solution is presented as a series sum over a spectrum of a discrete-index Hankel transform, and the spectral amplitudes are determined by solving an infinite linear system of equations, which is constructed by applying the orthogonality relation of the 1D Green\\'s function. © 2011 IEEE.

  1. Modal solutions in stratified multi-layered fluid-solid half-space

    Institute of Scientific and Technical Information of China (English)

    陈蔚天; 陈晓非

    2002-01-01

    A new systematic and efficient algorithm to calculate the modal solutions of multi-lay- ered ocean-Earth model is presented. Our algorithm distinguishes itself as terseness of formulation, efficiency in numerical computation, and stableness at high frequencies, thus, thoroughly solving the problem of loss-of-precision at high frequencies. This new algorithm is expected to be very useful in studying the surface waves propagating in ocean-Earth model and other related topics.

  2. Torsional vibrations of a cylindrical foundation embedded in a saturated poroelastic half-space

    Institute of Scientific and Technical Information of China (English)

    Dazhi WU; Lu YU

    2015-01-01

    Considering the interactions between an embedded foundation and saturated soil, the torsional vibrations of a cylindrical foundation embedded in a saturated poroelastic medium are analyzed in this paper. Both a rigid foundation and an elastic foundation are considered. Assuming both the side surface and the bottom surface of the foundation are perfectly bonded to soil, the reaction torques that the side soil and bottom soil acting on the foundation can be gained from basic dynamic equations of the poroelastic medium. According to the dynamic equilibrium equations of a foundation under harmonic torque, the torsional vibrations of an embedded cylindrical foundation are presented. Besides, the angular amplitude of the foundation, the equivalent stiffness and damping coefficients of the soil are expressed explicitly. Selected examples are presented to investigate the influence of relevant parameters on the torsional vibrations.

  3. Mitigation of Railway Traffic Induced Vibrations: The Influence of Barriers in Elastic Half-Space

    Directory of Open Access Journals (Sweden)

    Michele Buonsanti

    2009-01-01

    Full Text Available In this paper, the problem of vibrations induced by trains and their propagation through the soil is studied. Particular attention is focused on the vibration induced by trains in motion and on the effects of such vibrations on the foundations of buildings in proximity of the tracks. The interaction between propagating waves induced by trains in motion and buildings foundations is a problem which does not admit a straightforward analytical solution; thus a solution is given by the use of a model based on the finite elements method. Firstly, we analyze the theoretical aspects of the problem by considering constant or harmonic loads moving along a straight railway track; then, we define a transfer function soil-railway and the response function of the entire system. The study aims to address the wave propagation in an elastic semi-space and the presence in the ground of a discontinuity element, such as a barrier of a given depth is considered. The efficiency variation of barriers is analyzed in function of the different materials used, and different numerical simulations are analyzed in order to study how the wave propagation and the track-soil interaction are influenced by the membrane, seen as damping barrier.

  4. THE ELASTIC FIELD INDUCED BY A HEMISPHERICAL INCLUSION IN THE HALF-SPACE

    Institute of Scientific and Technical Information of China (English)

    吴林志

    2003-01-01

    The elastic field induced by a hemispherical inclusion with uniform eigenstrains in a semi-infinite elastic medium is solved by using the Green's function method and series expansion technique.The exact solutions are presented for the displacement and stress fields which can be expressed by complete elliptic integrals of the first,second,and third kinds and hypergeometric functions.The present method can be used to determine the corresponding elastic fields when the shape of the inclusion is a spherical crown or a spherical segment.Finally,numerical results are given for the displacement and stress fields along the axis of symmetry (x3-axis).

  5. Bow-tie antennas on a dielectric half-space - Theory and experiment

    Science.gov (United States)

    Compton, Richard C.; Mcphedran, Ross C.; Popovic, Zorana; Rebeiz, Gabriel M.; Tong, Peter P.

    1987-01-01

    A new formulation is discussed for the rigous calculation of the radiation pattern of a bow-tie antenna of finite length and infinitesimal thickness, placed on a lossless dielectric substrate. The analysis is based on a representation of the current density on the metal surface of the antenna as a sum of an imposed (quasistatic) term and a set of current modes with unknown amplitudes. Free-space fields that are expressed in terms of continuous spectra of symmetrized plane waves are matched to the current modes using the method of moments. The resulting set of equations are solved for the unknown current amplitudes. The calculations show that for increasing bow length the antenna impedance spirals rapidly to a value predicted by transmission line theory. The theory also shows that the E-plane pattern of a two-wavelength, 60-deg bow-tie antenna is dominated by low-loss current modes propagating at the dielectric wavenumber. As the bow tie narrows, the loss of the modes increases, and the dominant wavenumber tends to the quasi-static value. Pattern measurements made at 94 GHz are shown to agree well with theoretical predictions. Measurements for a long-wire antenna, a linear array of bow-tie elements, and a log-periodic antenna are also presented.

  6. State vector solutions for nonaxisymmetric problem of multilayered half space piezoelectric medium

    Institute of Scientific and Technical Information of China (English)

    王建国

    1999-01-01

    A state space formulation is established for the nonaxisymmetric space problem of transversely isotropic piezoelectric media in a system of cylindrical coordinate by introducing the state vector. Using the Hankel transform and the Fourier series, the state vector equations are transformed into ordinary differential equations. By the use of the matrix methods, the analytical solutions of a single piezoelectric layer are presented in the form of the product of initial state variables and transfer matrix. The applications of state vector solutions are discussed. An analytical solution for a semiinfinite piezoelectric medium subjected to the vertical point force P_z, horizontal point force P_x along x-direction and point electric charge Q at the origin of the surface is presented. According to the continuity conditions at the interfaces, the general solution formulation for N-layered transversely isotropic piezoelectric media is given.

  7. Surface effect on Bleustein-Gulyaev wave in a piezoelectric half-space

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Surface effect,which is attributed to the different environment surrounding the surface or near-surface atoms from that embracing the bulk atoms,may become significant when the surface-to-volume ratio of a body is large.This paper considers the effect of a plane boundary of a piezoelectric body modeled as a thin layer with specified material properties,for which a transfer relation between the state vectors at the top and bottom surfaces is derived based on the state-space formulations.The equations of surf...

  8. Disturbance due to mechanical and thermal sources in a generalized thermo-microstretch elastic half space

    Indian Academy of Sciences (India)

    Rajneesh Kumar; Sunita Deswal

    2001-12-01

    Disturbances caused by impulsive concentrated mechanical and thermal sources in a homogeneous, isotropic generalized thermo-microstretch elastic medium are studied by the use of Laplace-Hankel transform techniques. The integral transforms are inverted using a numerical technique. Analytical expressions for displacement components, stress, couple stress, microstress and temperature field are derived for different models of generalized thermoelasticity and illustrated graphically. These results for stresses and displacements can be used in estimating the effects of a surface pressure wave. Stretch and micropolar effects on various expressions obtained analytically are also depicted graphically.

  9. Torsional Loadings of a Semi-Infinite Perfectly Conducting Elastic Half Space

    Directory of Open Access Journals (Sweden)

    K. S. Sarma

    1971-07-01

    Full Text Available The problem of torsional oscillations of a semi infinite perfectly conducting elastic medium with an applied magnetic filed normal to the boundary due to (i an impulsive load,(ii step load, and (iii sinusoidal load are solved. In the case of impulsive loading over a circular region, the duration of disturbance at a point is greater than in the case of a purely elastic materials. The width of distribution is the same in both the cases.

  10. 几种乳酸菌S-层蛋白的普查以及slp基因的克隆与序列分析%Detection of S-layer protein for Lactobacillus spp.and molecular cloning and sequence analysis of the gene slp in L.acidophilus

    Institute of Scientific and Technical Information of China (English)

    双杰; 包秋华; 永胜; 王艳霞; 张和平; 格日勒图

    2010-01-01

    从内蒙古传统发酵乳制品中分离的几种乳酸菌,包括干酪乳杆菌、乳酸乳球菌、发酵乳杆菌、植物乳杆菌、嗜酸乳杆菌、双歧乳杆菌和嗜酸乳杆菌标准株(L.acidophilus ATCC4356)等为实验材料,应用SDS-PAGE方法和PCK方法分别进行S-层蛋白(S-layers pro-tein,SLP)的普查和slp基因的检测.结果表明:在各种乳酸茵中,经SDS-PAGE电泳方法检测,只有植物乳杆菌、嗜酸乳杆菌和其标准菌株的样品中出现膜外蛋白的可疑条带,大小为44~66ku之间,与文献报道的slp基因表达产物大小范围是一致;经PCR方法检测,只有嗜酸乳杆菌和其标准菌株L.acidoilus ATCC4356中扩增出slp基因可疑条带,其大小约为1 300 bp.并对嗜酸乳杆菌slp基因进行克隆、基因序列测序和分析.

  11. Fear of public speaking-the role of the SLP.

    Science.gov (United States)

    Breakey, Lisa K

    2005-05-01

    Although there are some individuals who have a true phobia of speaking in a public forum, public speaking is usually near the top of any list of activities that most individuals dislike, fear, or avoid. Such nonphobic speakers are the subjects of this article. They comprise individuals who, for various reasons, are (or fear they will be) inadequate speakers. This article is based on extensive clinical experience with such individuals. It describes some basic causes for these fears; considers evaluative and treatment procedures; and provides a rationale for the involvement of the speech-language pathologist in "wellness" management. For the purposes of this article, public speaking is defined as speaking before any group of individuals, regardless of the group's size.

  12. Distinct conformational and functional effects of two adjacent pathogenic mutations in cardiac troponin I at the interface with troponin T

    OpenAIRE

    Akhter, Shirin; Jin, J.-P.

    2015-01-01

    The α-helix in troponin I (TnI) at the interface with troponin T (TnT) is a highly conserved structure. A point mutation in this region, A116G, was found in human cardiac TnI in a case of cardiomyopathy. An adjacent dominantly negative mutation found in turkey cardiac TnI (R111C, equivalent to K117C in human and K118C in mouse) decreased diastolic function and blunted beta-adrenergic response in transgenic mice. To investigate the functional importance of the TnI–TnT interface and pathologica...

  13. Distinct conformational and functional effects of two adjacent pathogenic mutations in cardiac troponin I at the interface with troponin T.

    Science.gov (United States)

    Akhter, Shirin; Jin, J-P

    2015-01-01

    The α-helix in troponin I (TnI) at the interface with troponin T (TnT) is a highly conserved structure. A point mutation in this region, A116G, was found in human cardiac TnI in a case of cardiomyopathy. An adjacent dominantly negative mutation found in turkey cardiac TnI (R111C, equivalent to K117C in human and K118C in mouse) decreased diastolic function and blunted beta-adrenergic response in transgenic mice. To investigate the functional importance of the TnI-TnT interface and pathological impact of the cardiac TnI mutations, we engineered K118C and A117G mutations in mouse cardiac TnI for functional studies. Despite their adjacent locations, A117G substitution results in faster mobility of cardiac TnI in SDS-PAGE whereas K118C decreases gel mobility, indicating significant and distinct changes in overall protein conformation. Consistently, monoclonal antibody epitope analysis demonstrated distinct local and remote conformational alterations in the two mutant proteins. Protein binding assays showed that K118C, but not A117G, decreased the relative binding affinity of cardiac TnI for TnT. K118C mutation decreased binding affinity for troponin C in a Ca(2+)-dependent manner, whereas A117G had a similar but less profound effect. Protein kinase A phosphorylation or truncation to remove the cardiac specific N-terminal extension of cardiac TnI resulted in similar conformational changes in the region interfacing with TnT and minimized the functional impacts of the mutations. The data demonstrate potent conformational and functional impacts of the TnT-interfacing helix in TnI and suggest a role of the N-terminal extension of cardiac TnI in modulating TnI-TnT interface functions.

  14. Tidal and non-tidal sea level variations at two adjacent ports on the southwest coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Srinivas, K.; DineshKumar, P.K.

    for the higher amplitudes of shallow water components. Meteorological residuals The regular and predictable tidal movements of the sea are continuously modified by the effects of the weather. Exchange of energy between the ocean and atmosphere occurs over a... to stormy weather. Even though tidal variations can be removed in the analysis, there could be energy in the tidal frequencies because of small timing errors in the gauge and weak interaction between the tides and the surges. The meteorological...

  15. Stability analysis and determination of rock pillar between two adjacent caverns in different regions of Asmari formation in Iran

    Institute of Scientific and Technical Information of China (English)

    Abdollahipour Abolfazl a; ⇑; Ghannadshirazi Hossein b

    2014-01-01

    Large underground caverns are commonly used in variety of applications. In many cases, because of the geomechanical limitations of dimensions and requirement of high volume, several parallel caverns are used. Plastic zone integration requires a larger rock pillar distance of theses adjacent caverns while eco-nomic and access reasons require smaller distance. In Iran many underground projects are located in West and South West. Asmari formation covers a large part of these regions. The stability of underground spaces that are constructed or will be constructed in this formation has been investigated. A proper cross section based on plastic analysis and a stability criterion has been proposed for each region. Finally, in each case, allowable rock pillar between adjacent caverns with similar dimension was determined with two methods (numerical analysis and fire service law). Results show that Fire Service Law uses a very con-servative safety factor and it was proposed to use a correction factor for allowable distance based on application of underground space.

  16. Mixed convection from a discrete heat source in enclosures with two adjacent moving walls and filled with micropolar nanofluids

    Directory of Open Access Journals (Sweden)

    Sameh E. Ahmed

    2016-03-01

    Full Text Available This paper examines numerically the thermal and flow field characteristics of the laminar steady mixed convection flow in a square lid-driven enclosure filled with water-based micropolar nanofluids by using the finite volume method. While a uniform heat source is located on a part of the bottom of the enclosure, both the right and left sidewalls are considered adiabatic together with the remaining parts of the bottom wall. The upper wall is maintained at a relatively low temperature. Both the upper and left sidewalls move at a uniform lid-driven velocity and four different cases of the moving lid ordinations are considered. The fluid inside the enclosure is a water based micropolar nanofluid containing different types of solid spherical nanoparticles: Cu, Ag, Al2O3, and TiO2. Based on the numerical results, the effects of the dominant parameters such as Richardson number, nanofluid type, length and location of the heat source, solid volume fractions, moving lid orientations and dimensionless viscosity are examined. Comparisons with previously numerical works are performed and good agreements between the results are observed. It is found that the average Nusselt number along the heat source decreases as the heat source length increases while it increases when the solid volume fraction increases. Also, the results of the present study indicate that both the local and the average Nusselt numbers along the heat source have the highest value for the fourth case (C4. Moreover, it is observed that both the Richardson number and moving lid ordinations have a significant effect on the flow and thermal fields in the enclosure.

  17. A study of electric field components in shallow water and water half-space models in seabed logging

    Science.gov (United States)

    Rostami, Amir; Soleimani, Hassan; Yahya, Noorhana; Nyamasvisva, Tadiwa Elisha; Rauf, Muhammad

    2016-11-01

    Seabed logging (SBL) is an electromagnetic (EM) method to detect hydrocarbon (HC) laid beneath the seafloor, which is a development of marine controlled source electromagnetic (CSEM) method. CSEM is a method to show resistivity log of geological layers, transmitting ultra-low frequency EM wave. In SBL a net of receivers, placed on the seafloor, detect reflected and refracted EM wave by layers with different resistivity. Contrast of electrical resistivity of layers impacts on amplitude and phase of the EM wave response. The most indispensable concern in SBL is to detect guided wave via high resistive layer under the seafloor that can be an HC reservoir. Guided wave by HC creates a remarkable difference in received signal when HC reservoir does not exist. While the major contribution of received EM wave in large offset, especially in shallow water environment, is airwave, which is refracted by sea surface due to extremely high resistivity of atmosphere, airwave can affect received guided wave, dramatically. Our objective for this work is to compare HC delineation of tangential and normal components of electric field in shallow water area, using finite element method simulation. Will be reported that, in shallow water environment, minor contribution of air wave in normal component of E field (Ey) versus its major contribution in the tangential component (Ex), causes a considerable contrast on HC delineation of Ey for deeply buried reservoirs (more than 3000 m), while Ex is unable to show different contrasts of received data for with and without HC media at the same condition.

  18. Implementation of diffuse-reflection boundary conditions using lattice Boltzmann models based on half-space Gauss-Laguerre quadratures.

    Science.gov (United States)

    Ambruş, Victor Eugen; Sofonea, Victor

    2014-04-01

    The Gauss-Laguerre quadrature method is used on the Cartesian semiaxes in the momentum space to construct a family of lattice Boltzmann models. When all quadrature orders Qx, Qy, Qz equal N+1, the Laguerre lattice Boltzmann model LLB(Qx,Qy,Qz) exactly recovers all moments up to order N of the Maxwell-Boltzmann equilibrium distribution function f(eq), calculated over any Cartesian octant of the three-dimensional momentum space. Results of Couette flow simulations at Kn=0.1, 0.5, 1.0 and in the ballistic regime are reported. Specific microfluidic effects (velocity slip, temperature jump, longitudinal heat flux) are well captured up to Kn=0.5, as demonstrated by comparison to direct simulation Monte Carlo results. Excellent agreement with analytic results is obtained in the ballistic regime.

  19. Anti-plane deformations around arbitrary-shaped canyons on a wedge-shape half-space: moment method solutions

    Institute of Scientific and Technical Information of China (English)

    Nazaret Dermendjian; Vincent W. Lee; Jianwen Liang(梁建文)

    2003-01-01

    The wave propagation behavior in an elastic wedge-shaped medium with an arbitrary shaped cylindrical canyon at its vertex has been studied. Nunerical computation of the wave displacement field is carried out on and near the canyon surfaces using weighted-residuals (moment method). The wave displacement fields are computed by the residual mcthod for the cases of elliptic, circular, rounded-rectangular and flat-elliptic canyons. The analysis demonstrates that thc resulting surface displacemcnt depends, as in similar previous analyses, on several factors including, but not limited, to the angle of thc wedge, thc geometry of thc vertex, the frcquencies of thc incident waves, the angles of incidence, and the material properties of the media. The analysis provides intriguing results that help to explain geophysical observations regarding the amplification of seismic energy as a function of site conditions.

  20. Exact Solution for an Anti-Plane Interface Crack between Two Dissimilar Magneto-Electro-Elastic Half-Spaces

    Directory of Open Access Journals (Sweden)

    Bogdan Rogowski

    2012-01-01

    Full Text Available This paper investigated the fracture behaviour of a piezo-electro-magneto-elastic medium subjected to electro-magneto-mechanical loads. The bimaterial medium contains a crack which lies at interface and is parallel to their poling direction. Fourier transform technique is used to reduce the problem to three pairs of dual integral equations. These equations are solved exactly. The semipermeable crack-face magneto-electric boundary conditions are utilized. Field intensity factors of stress, electric displacement, magnetic induction, cracks displacement, electric and magnetic potentials, and the energy release rate are determined. The electric displacement and magnetic induction of crack interior are discussed. Obtained results indicate that the stress field and electric and magnetic fields near the crack tips exhibit square-root singularity.

  1. The Effects of Piezoelectricity on the Interaction of Waves in Fluid-Loaded Poroelastic Half-Space

    Directory of Open Access Journals (Sweden)

    Vishakha Gupta

    2014-01-01

    Full Text Available The effects of piezoelectricity on the interaction of waves at fluid-poroelastic interface are studied. The constitutive equations and governing equations are formulated and their solution is obtained. The boundary conditions are described at fluid-solid interface. The effects of various parameters on the angle of refraction, amplitude ratios, displacements, electric potentials, and vertical component of slowness are studied numerically for a particular model. The results obtained are in agreement with the general laws of physics.

  2. Scattering and Imaging of Nonlinearly Loaded Antenna Structures in Half-Space and Complex-Room Environments

    Science.gov (United States)

    2014-09-01

    furthermore, direction-of-arrival and time-of-arrival processing can be combined to obtain the absolute position of the target. A survey of the literature...Zhang W, Hoorfar A, Li L. Through-the-wall target localization with time reversal MUSIC method. Prog Electromagn Res. 2010;106:75–89. 34. Marengo EA...Gruber FK, Simonetti F. Time-reversal MUSIC imaging of extended targets. IEEE Trans Image Process. 2007;16:1967–1984. 35. Hou S, Solna K, Zhao H. A

  3. Distinct groundwater recharge sources and geochemical evolution of two adjacent sub-basins in the lower Shule River Basin, northwest China

    Science.gov (United States)

    Wang, Liheng; Dong, Yanhui; Xie, Yueqing; Song, Fan; Wei, Yaqiang; Zhang, Jiangyi

    2016-08-01

    Based on analysis of groundwater hydrogeochemical and isotopic data, this study aims to identify the recharge sources and understand geochemical evolution of groundwater along the downstream section of the Shule River, northwest China, including two sub-basins. Groundwater samples from the Tashi sub-basin show markedly depleted stable isotopes compared to those in the Guazhou sub-basin. This difference suggests that groundwater in the Tashi sub-basin mainly originates from meltwater in the Qilian Mountains, while the groundwater in the Guazhou sub-basin may be recharged by seepage of the Shule River water. During the groundwater flow process in the Tashi sub-basin, minerals within the aquifer material (e.g., halite, calcite, dolomite, gypsum) dissolve in groundwater. Mineral dissolution leads to strongly linear relationships between Na+ and Cl- and between Mg2++ Ca2+ and SO4 2- + HCO3 -, with stoichiometry ratios of approximately 1:1 in both cases. The ion-exchange reaction plays a dominant role in hydrogeochemical evolution of groundwater in the Guazhou sub-basin and causes a good linear relationship between (Mg2++ Ca2+)-(SO4 2- + HCO3 -) and (Na++ K+)-Cl- with a slope of -0.89 and also results in positive chloroalkaline indices CAI 1 and CAI 2. The scientific results have implications for groundwater management in the downstream section of Shule River. As an important irrigation district in Hexi Corridor, groundwater in the Guazhou sub-basin should be used sustainably and rationally because its recharge source is not as abundant as expected. It is recommended that the surface water should be used efficiently and routinely, while groundwater exploitation should be limited as much as possible.

  4. Using a morpho-functional approach to assess phytoplankton dynamics in two adjacent high-mountain lakes: a 10-year survey

    Directory of Open Access Journals (Sweden)

    Renata Trevisan

    2014-05-01

    Full Text Available Colbricon Superiore and Inferiore are two small adjacent high-mountain lakes located in the Paneveggio Natural Park (Italy. The lakes differ by size and depth while sharing the same bedrock setting and catchment basin. Changes in the phytoplankton communities were studied over a 10-years period to individuate which environmental variables would determine the main differences in biotic assemblages across time and between the two lakes.The study was conducted with fortnightly samplings, assessing the density and biomass of algal taxa. Relationships of each of the biological variables with water temperature, pH, conductivity, transparency, water level, previous week rainfall, and relative water column stability were analyzed by correlation and regression analyses, cluster analysis, and by canonical correspondence analysis. The most significant variables resulted air temperature, hydrologic water level and pH. The smaller Colbricon Inferiore had about double the amount of phytoplankton density and biomass than did the larger Colbricon Superiore. The same lake had higher diversity and lower evenness in structure of the phytoplankton community. Notwithstanding their proximity each lake appears to follow independent species composition dynamics, however parallel patterns were interestingly revealed when data were analyzed by pooling taxa into morpho-functional groups. Morpho-functional groups (MFGs 1b, 3a, 6b, 7a, 9b were differentially most abundant in warm periods, while 2c, 3b, 11c, 5e, 10a prevailed in cold years. MFGs 1b, 2d, 3a and 3b were more characteristic of Lake Colbricon Superiore, while Colbricon Inferiore preferentially featured MFGs 5a, 5e, 9a, 9b, 10a, 11a and 8a. The role of the meteo-climatic parameters was pointed out in driving the different patterns observed in the two lakes.

  5. Non-free ionic transport of sodium, magnesium, and calcium in streams of two adjacent headwater catchments with different vegetation types in Japan

    Science.gov (United States)

    Terajima, Tomomi; Moriizumi, Mihoko; Nakamura, Tomohiro

    2017-01-01

    Sodium (Na), magnesium (Mg), calcium (Ca) are usually believed to occur mostly as free ions in the fresh water and consequently little is known about their chemical species. To understand the importance of non-free ionic fractions (NIF) of major metals in freshwater streams, Na, Mg, Ca, silicon (Si), and fulvic acid-like materials (FAM) were measured in streams of mountainous adjacent headwater catchments dominated by different vegetation types (planted evergreen coniferous forest and natural deciduous broadleaf forest). During both no rainfall periods and rainstorms, the proportion of NIF relative to total elements was lower in the coniferous catchment than in the deciduous catchment, although it sometimes accounted for half or more of the total concentrations of Na, Mg, and Ca in both catchments. The solubility of metal compounds was higher than the measured maximum concentrations of Na+, Mg2+, and Ca2+ to the extent that inorganic bonding was hardly possible. During no rainfall periods when FAM was slightly produced into the streams, the fluxes of NIF and Si were highly correlated (r > 0.92, p NIF correlated weakly with that of Si but did not correlate with that of FAM in both catchments. In contrast, during a heavy rainstorm, the flux of NIF correlated strongly (r ⩾ 0.83, p NIF originated in the quick-flow component (i.e., surface or near-surface water) in stream water (ΔNIF) correlated strongly (r ⩾ 0.81, p < 0.0001, n = 22) with that of FAM. These findings imply that heavy rainstorms may enhance the bonding of the major metals with humic substances mainly in the deciduous catchment; and also exhibit that, in the headwater catchments, both water flow pathways resulted from the different vegetation types play a very important role to promote the bonding of major metals with humic substances in stream water.

  6. Elmore Delay Estimation of Two Adjacent Coupling Interconnects%两相邻耦合互连的Elmore延时估计

    Institute of Scientific and Technical Information of China (English)

    董刚; 杨银堂; 李跃进

    2006-01-01

    An approach for analyzing coupling RC interconnect delay based on "effective capacitance" is presen ted. We compare this new method to the traditional method, which uses Miller capacitance. The results show that the new method not only improves the accuracy but also reflects the delay dependence on rise time. The method has the same complexity as the Elmore delay model and can be used in performance-driven routing optimization.%基于"有效电容"的概念提出了一种分析两相邻耦合RC互连延时的方法.与采用Miller电容的传统方法比较,该方法不但提高了计算精度而且反映出了延时随信号上升时间的变化规律.该方法与Elmore延时法具有相同的计算复杂度,可广泛用于考虑耦合电容的面向性能的布线优化.

  7. Modeling the impacts of winter cover crops on water quality in two adjacent sub-watersheds within the Chesapeake Bay Watershed, Maryland, USA

    Science.gov (United States)

    The Choptank River on Maryland’s Eastern Shore has been designated by the USEPA as “impaired waters” under Section 303(d) of the Federal Clean Water Act of 1972, mainly because of significant nutrient loads that resulted in not meeting the EPA water quality standards. This water quality deteriorati...

  8. Multiple Genome Comparison within a Bacterial Species Reveals a Unit of Evolution Spanning Two Adjacent Genes in a Tandem Paralog Cluster

    Science.gov (United States)

    Tsuru, Takeshi

    2008-01-01

    It has been assumed that an open reading frame (ORF) represents a unit of gene evolution as well as a unit of gene expression and function. In the present work, we report a case in which a unit comprising the 3′ region of an ORF linked to a downstream intergenic region that is in turn linked to the 5′ region of a downstream ORF has been conserved, and has served as the unit of gene evolution. The genes are tandem paralogous genes from the bacterium Staphylococcus aureus, for which more than ten entire genomes have been sequenced. We compared these multiple genome sequences at a locus for the lpl (lipoprotein-like) cluster (encoding lipoprotein homologs presumably related to their host interaction) in the genomic island termed νSaα. A highly conserved nucleotide sequence found within every lpl ORF is likely to provide a site for homologous recombination. Comparison of phylogenies of the 5′-variable region and the 3′-variable region within the same ORF revealed significant incongruence. In contrast, pairs of the 3′-variable region of an ORF and the 5′-variable region of the next downstream ORF gave more congruent phylogenies, with distinct groups of conserved pairs. The intergenic region seemed to have coevolved with the flanking variable regions. Multiple recombination events at the central conserved region appear to have caused various types of rearrangements among strains, shuffling the two variable regions in one ORF, but maintaining a conserved unit comprising the 3′-variable region, the intergenic region, and the 5′-variable region spanning adjacent ORFs. This result has strong impact on our understanding of gene evolution because most gene lineages underwent tandem duplication and then diversified. This work also illustrates the use of multiple genome sequences for high-resolution evolutionary analysis within the same species. PMID:18765438

  9. Distinct groundwater recharge sources and geochemical evolution of two adjacent sub-basins in the lower Shule River Basin, northwest China

    Science.gov (United States)

    Wang, Liheng; Dong, Yanhui; Xie, Yueqing; Song, Fan; Wei, Yaqiang; Zhang, Jiangyi

    2016-12-01

    Based on analysis of groundwater hydrogeochemical and isotopic data, this study aims to identify the recharge sources and understand geochemical evolution of groundwater along the downstream section of the Shule River, northwest China, including two sub-basins. Groundwater samples from the Tashi sub-basin show markedly depleted stable isotopes compared to those in the Guazhou sub-basin. This difference suggests that groundwater in the Tashi sub-basin mainly originates from meltwater in the Qilian Mountains, while the groundwater in the Guazhou sub-basin may be recharged by seepage of the Shule River water. During the groundwater flow process in the Tashi sub-basin, minerals within the aquifer material (e.g., halite, calcite, dolomite, gypsum) dissolve in groundwater. Mineral dissolution leads to strongly linear relationships between Na+ and Cl- and between Mg2++ Ca2+ and SO4 2- + HCO3 -, with stoichiometry ratios of approximately 1:1 in both cases. The ion-exchange reaction plays a dominant role in hydrogeochemical evolution of groundwater in the Guazhou sub-basin and causes a good linear relationship between (Mg2++ Ca2+)-(SO4 2- + HCO3 -) and (Na++ K+)-Cl- with a slope of -0.89 and also results in positive chloroalkaline indices CAI 1 and CAI 2. The scientific results have implications for groundwater management in the downstream section of Shule River. As an important irrigation district in Hexi Corridor, groundwater in the Guazhou sub-basin should be used sustainably and rationally because its recharge source is not as abundant as expected. It is recommended that the surface water should be used efficiently and routinely, while groundwater exploitation should be limited as much as possible.

  10. The Hansenula polymorpha per6 mutant is affected in two adjacent genes which encode dihydroxyacetone kinase and a novel protein, Pak1p, involved in peroxisome integrity

    NARCIS (Netherlands)

    Klei, Ida J. van der; Heide, Meis van der; Baerends, Richard J.S.; Rechinger, Karl-Björn; Nicolay, Klaas; Kiel, Jan A.K.W.; Veenhuis, Marten

    1998-01-01

    The Hansenula polymorpha per6-210 mutant is impaired in respect of growth on methanol (Mut–) and is characterized by aberrant peroxisome formation. The functionally complementing DNA fragment contains two open reading frames. The first encodes dihydroxyacetone kinase (DAK), a cytosolic enzyme essent

  11. Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein

    DEFF Research Database (Denmark)

    Keck, Zhenyong; Wang, Wenyan; Wang, Yong

    2013-01-01

    polyclonal antibodies to aa 412 to 423 from HCV-infected individuals confirmed broad neutralization, conflicting findings have been reported on polyclonal antibodies to an adjacent region, aa 434 to 446, that may or may not interfere with neutralization by antibodies to aa 412 to 423. To define the interplay......A challenge for hepatitis C virus (HCV) vaccine development is defining conserved epitopes that induce protective antibodies against this highly diverse virus. An envelope glycoprotein (E2) segment located at amino acids (aa) 412 to 423 contains highly conserved neutralizing epitopes. While...... between these antibodies, we isolated human monoclonal antibodies (HMAbs) to aa 412 to 423, designated HC33-related HMAbs (HC33 HMAbs), and characterized their interactions with other HMAbs to aa 434 to 446. A subset of the HC33 HMAbs neutralized genotype 1 to 6 infectious cell culture-derived HCV virions...

  12. 有限元分析压电半空间接触问题%Finite Element Method for Contact Problem of Piezoelectric Half-space

    Institute of Scientific and Technical Information of China (English)

    高鹏博; 刘铁军

    2016-01-01

    压电材料作为一种拥有优越机电耦合性能的智能材料,其力学性能受到了研究者的广泛关注.本文采用有限元方法分析压电半空间在刚性球形压头和刚性圆柱平底压头作用下的压痕响应.文中假定两种形状的刚性压头均为绝缘体压头.利用有限元软件ANSYS,本文分析了在荷载作用下,压电材料在球形和圆柱形压头作用下的压入深度、接触半径、表面接触应力和接触区域电势曲线.另外,本文还利用数值结果对理论解进行验证.

  13. Fast Domain Partitioning Method for dynamic boundary integral equations applicable to non-planar faults dipping in 3-D elastic half-space

    Science.gov (United States)

    Ando, Ryosuke

    2016-11-01

    The elastodynamic boundary integral equation method (BIEM) in real space and in the temporal domain is an accurate semi-analytical tool to investigate the earthquake rupture dynamics on non-planar faults. However, its heavy computational demand for a historic integral generally increases with a time complexity of O(MN3)for the number of time steps N and elements M due to volume integration in the causality cone. In this study, we introduce an efficient BIEM, termed the `Fast Domain Partitioning Method' (FDPM), which enables us to reduce the computation time to the order of the surface integral, O(MN2), without degrading the accuracy. The memory requirement is also reduced to O(M2) from O(M2N). FDPM uses the physical nature of Green's function for stress to partition the causality cone into the domains of the P and S wave fronts, the domain in-between the P and S wave fronts, and the domain of the static equilibrium, where the latter two domains exhibit simpler dependences on time and/or space. The scalability of this method is demonstrated on the large-scale parallel computing environments of distributed memory systems. It is also shown that FDPM enables an efficient use of memory storage, which makes it possible to reduce computation times to a previously unprecedented level. We thus present FDPM as a powerful tool to break through the current fundamental difficulties in running dynamic simulations of coseismic ruptures and earthquake cycles under realistic conditions of fault geometries.

  14. Investigation of Space-Time Structure of the Discharge with an Electrolytic Anode and Face-Type, Air Half-Space Directed Cathode (Gatchina's Discharge)

    CERN Document Server

    Emelin, S E; Pirozerski, A L

    2008-01-01

    Despite of its limited capabilities for ball-lightning modeling, the chemically active dust plasma of electric discharges is a very interesting physical object. Gatchina's discharge, which gives a possibility to study the dust-gas fireball, represents a complex non-stationary process, combining the creation and the destruction of relatively long-living high-enthalpy microscopic states with non-ideal dust plasma and with a gas-dynamic form, resulting in appearance of a spherical luminous object. In the present work we studied spatial structure of the discharge and its dynamics with the help of electric and optical measurements.

  15. Boundary Element Analysis of the Steady-state Response of an Elastic Half-Space to a Moving Force on its Surface

    DEFF Research Database (Denmark)

    Andersen, Lars; Nielsen, Søren R. K.

    2003-01-01

    . This is appropriate for the analysis of, for example, ground borne noise from railway or road traffic. The frequency-domain fundamental solution is derived from corresponding time-domain solution by means of Fourier transformation. To obtain a closed form solution, a part of the time-domain kernel functions...

  16. Response of thermal source in a transversely isotropic thermoelastic half-space with mass diffusion by using a finite element method

    Institute of Scientific and Technical Information of China (English)

    Ibrahim A. Abbas; Rajneesh Kumar; Vijay Chawla

    2012-01-01

    The two-dimensional problem of generalized thermoelastic diffusion material with thermal and diffusion relaxation times is investigated in the context of the Lord-Shulman theory.As an application of the problem,a particular type of thermal source is considered and the problem is solved numerically by using a finite element method.The components of displacement,stress,temperature distribution,chemical potential,and mass concentration are obtained.The resulting quantities are depicted graphically for a special model.An appreciable effect of relaxation times is observed on various resulting quantities.

  17. Love Wave in Graded Half-Space with Homogeneous Layer%均匀覆层梯度半空间中的Love面波

    Institute of Scientific and Technical Information of China (English)

    张立刚; 盖秉政; 朱虹

    2007-01-01

    对覆盖一层均匀各向同性材料的功能梯度半空间中的Love波频散问题进行了研究,给出了Love波频散方程的一般形式.对功能梯度半空间的反平面剪切波的运动控制方程进行了求解,给出了半空间的位移、应力解析解,导出了该解析解下的Love波频散方程的一般形式.以功能梯度材料的剪切弹性模量和质量密度沿深度方向均呈指数变化和抛物线变化两种情况为例,进行了计算和分析,给出了频散曲线.结果显示:在最低阶振型频散曲线中出现了截止频率.

  18. Propagation of Love waves with surface effects in an electrically-shorted piezoelectric nanofilm on a half-space elastic substrate.

    Science.gov (United States)

    Zhang, Sijia; Gu, Bin; Zhang, Hongbin; Feng, Xi-Qiao; Pan, Rongying; Alamusi; Hu, Ning

    2016-03-01

    The propagation of Love waves in the structure consisting of a nanosized piezoelectric film and a semi-infinite elastic substrate is investigated in the present paper with the consideration of surface effects. In our analysis, surface effects are taken into account in terms of the surface elasticity theory and the electrically-shorted conditions are adopted on the free surface of the piezoelectric film and the interface between the film and the substrate. This work focuses on the new features in the dispersion relations of different modes due to surface effects. It is found that with the existence of surface effects, the frequency dispersion of Love waves shows the distinct dependence on the thickness and the surface constants when the film thickness reduces to nanometers. In general, phase velocities of all dispersion modes increase with the decrease of the film thickness and the increase of the surface constants. However, surface effects play different functions in the frequency dispersions of different modes, especially for the first mode dispersion. Moreover, different forms of Love waves are observed in the first mode dispersion, depending on the presence of the surface effects on the surface and the interface.

  19. LOVE WAVES IN A GRADED HALF-SPACE WITH A GRADED LAYER%梯度半空间梯度覆层中的Love波

    Institute of Scientific and Technical Information of China (English)

    张立刚; 盖秉政; 朱虹; 袁林

    2007-01-01

    对功能梯度弹性半空间上覆盖一层功能梯度材料中的Love波的频散问题进行了研究,给出了Love波频散方程的一般形式.对功能梯度弹性半空间和功能梯度覆层的反平面剪切波的运动控制方程进行了求解,给出了半空间和覆盖层的位移、应力解析解,给出了Love波在该解析解下的频散方程.以覆盖层的剪切弹性模量和质量密度均呈指数函数变化,半空间的剪切弹性模量和质量密度均呈抛物线变化为例,利用迭代方法对频散方程进行了求解,给出了频散曲线.结果显示:在最低阶振型频散曲线中出现截止频率.

  20. Productivity of Chlorella sorokiniana in a short light-path (SLP) panel photobioreactor under high irradiance

    NARCIS (Netherlands)

    Cuaresma, M.; Janssen, M.G.J.; Vilchez, C.; Wijffels, R.H.

    2009-01-01

    Maximal productivity of a 14 mm light-path panel photobioreactor under high irradiance was determined. Under continuous illumination of 2,100 µmol photons m-2 s-1 with red light emitting diodes (LEDs) the effect of dilution rate on photobioreactor productivity was studied. The light intensity used

  1. Productivity of Chlorella sorokiniana in a short light-path (SLP) panel photobioreactor under high irradiance

    NARCIS (Netherlands)

    Cuaresma, M.; Janssen, M.G.J.; Vilchez, C.; Wijffels, R.H.

    2009-01-01

    Maximal productivity of a 14 mm light-path panel photobioreactor under high irradiance was determined. Under continuous illumination of 2,100 µmol photons m-2 s-1 with red light emitting diodes (LEDs) the effect of dilution rate on photobioreactor productivity was studied. The light intensity used i

  2. Essentials of Epidemiology and Phenomenology of Stuttering – Consequences for Clinical SLP Practice

    OpenAIRE

    Boey, Ronny

    2012-01-01

    The Antwerp epidemiological and phenomenological study on stuttering focuses on the onset and development of stuttering. Descriptive data related to the onset of stuttering were obtained for a group of 1549 participants. The reported and observed variables were obtained in order to test several hypotheses concerning the age-related, gender-related and interrelated phenomena. The following aspects of stuttering and the related phenomena were studied: (a) stuttering-like disfluencies (typ...

  3. Essentials of Epidemiology and Phenomenology of Stuttering – Consequences for Clinical SLP Practice

    OpenAIRE

    Boey, Ronny

    2012-01-01

    The Antwerp epidemiological and phenomenological study on stuttering focuses on the onset and development of stuttering. Descriptive data related to the onset of stuttering were obtained for a group of 1549 participants. The reported and observed variables were obtained in order to test several hypotheses concerning the age-related, gender-related and interrelated phenomena. The following aspects of stuttering and the related phenomena were studied: (a) stuttering-like disfluencies (typ...

  4. Generation and use of the Goddard trajectory determination system SLP ephemeris files

    Science.gov (United States)

    Armstrong, M. G.; Tomaszewski, I. B.

    1973-01-01

    Information is presented to acquaint users of the Goddard Trajectory Determination System Solar/Lunar/Planetary ephemeris files with the details connected with the generation and use of these files. In particular, certain sections constitute a user's manual for the ephemeris files.

  5. A Novel Insecticidal Peptide SLP1 Produced by Streptomyces laindensis H008 against Lipaphis erysimi.

    Science.gov (United States)

    Xu, Lijian; Liang, Kangkang; Duan, Bensha; Yu, Mengdi; Meng, Wei; Wang, Qinggui; Yu, Qiong

    2016-08-22

    Aphids are major insect pests for crops, causing damage by direct feeding and transmission of plant diseases. This paper was completed to discover and characterize a novel insecticidal metabolite against aphids from soil actinobacteria. An insecticidal activity assay was used to screen 180 bacterial strains from soil samples against mustard aphid, Lipaphis erysimi. The bacterial strain H008 showed the strongest activity, and it was identified by the phylogenetic analysis of the 16S rRNA gene and physiological traits as a novel species of genus Streptomyces (named S. laindensis H008). With the bioassay-guided method, the insecticidal extract from S. laindensis H008 was subjected to chromatographic separations. Finally, a novel insecticidal peptide was purified from Streptomyces laindensis H008 against L. erysimi, and it was determined to be S-E-P-A-Q-I-V-I-V-D-G-V-D-Y-W by TOF-MS and amino acid analysis.

  6. A Novel Insecticidal Peptide SLP1 Produced by Streptomyces laindensis H008 against Lipaphis erysimi

    Directory of Open Access Journals (Sweden)

    Lijian Xu

    2016-08-01

    Full Text Available Aphids are major insect pests for crops, causing damage by direct feeding and transmission of plant diseases. This paper was completed to discover and characterize a novel insecticidal metabolite against aphids from soil actinobacteria. An insecticidal activity assay was used to screen 180 bacterial strains from soil samples against mustard aphid, Lipaphis erysimi. The bacterial strain H008 showed the strongest activity, and it was identified by the phylogenetic analysis of the 16S rRNA gene and physiological traits as a novel species of genus Streptomyces (named S. laindensis H008. With the bioassay-guided method, the insecticidal extract from S. laindensis H008 was subjected to chromatographic separations. Finally, a novel insecticidal peptide was purified from Streptomyces laindensis H008 against L. erysimi, and it was determined to be S-E-P-A-Q-I-V-I-V-D-G-V-D-Y-W by TOF-MS and amino acid analysis.

  7. Purification and characterization of DR_2577 (SlpA) a major S-layer protein from Deinococcus radiodurans.

    Science.gov (United States)

    Farci, Domenica; Bowler, Matthew W; Esposito, Francesca; McSweeney, Sean; Tramontano, Enzo; Piano, Dario

    2015-01-01

    The protein DR_2577 is a major Surface layer component of the radio-resistant bacterium Deinococcus radiodurans. In the present study DR_2577 has been purified and its oligomeric profile characterized by means of size exclusion chromatography and gel electrophoresis. DR_2577 was found to be organized into three hierarchical orders characterized by monomers, stable dimers formed by the occurrence of disulfide bonds, and hexamers resulting from a combination of dimers. The structural implications of these findings are discussed providing new elements for a more integrated model of this S-layer.

  8. Profile of Secreted Hydrolases, Associated Proteins, and SlpA in Thermoanaerobacterium saccharolyticum during the Degradation of Hemicellulose

    Energy Technology Data Exchange (ETDEWEB)

    Currie, Devin [Dartmouth College; Guss, Adam M [ORNL; Herring, Christopher [Mascoma Corporation; Giannone, Richard J [ORNL; Johnson, Courtney M [ORNL; Lankford, Patricia K [ORNL; Brown, Steven D [ORNL; Hettich, Robert {Bob} L [ORNL; Lynd, Lee R [Thayer School of Engineering at Dartmouth

    2014-01-01

    Thermoanaerobacterium saccharolyticum, a Gram-positive thermophilic anaerobic bacterium, grows robustly on insoluble hemicellulose, which requires a specialized suite of secreted and transmembrane proteins. We report here the characterization of proteins secreted by this organism. Cultures were grown on hemicellulose, glucose, xylose, starch, and xylan in pH-controlled bioreactors, and samples were analyzed via spotted microarrays and liquid chromatography-mass spectrometry. Key hydrolases and transporters employed by T. saccharolyticum for growth on hemicellulose were, for the most part, hitherto uncharacterized and existed in two clusters (Tsac_1445 through Tsac_1464 for xylan/xylose and Tsac_1344 through Tsac_1349 for starch). A phosphotransferase system subunit, Tsac_0032, also appeared to be exclusive to growth on glucose. Previously identified hydrolases that showed strong conditional expression changes included XynA (Tsac_1459), XynC (Tsac_0897), and a pullulanase, Apu (Tsac_1342). An omnipresent transcript and protein making up a large percentage of the overall secretome, Tsac_0361, was tentatively identified as the primary S-layer component in T. saccharolyticum, and deletion of the Tsac_0361 gene resulted in gross morphological changes to the cells. The view of hemicellulose degradation revealed here will be enabling for metabolic engineering efforts in biofuel-producing organisms that degrade cellulose well but lack the ability to catabolize C5 sugars

  9. VALORACIÓN ECONÓMICA POR LA REHABILITACIÓN DEL RÍO AXTLA, S.L.P.

    OpenAIRE

    Ramón Valdivia-Alcalá; Emiliano García-Avalos; Marco Andrés López-Santiago; Juan Hernández-Ortíz; Abraham Rojano-Aguilar

    2011-01-01

    En este trabajo se muestran los resultados de la disposición a pagar (DAP) por la protección, mantenimiento y mejora del río Axtla, por parte de los habitantes de Axtla de Terrazas, San Luis Potosí. Esto se llevó a cabo a través del método de valoración contingente con formato referéndum (MVCR). Los resultados obtenidos se analizaron mediante técnicas de regresión logística vía máxima verosimilitud. Se concluye que las variables ingreso familiar, educación y afectación por la contaminación in...

  10. Purification and characterization of DR_2577 (SlpA) a major S-layer protein from Deinococcus radiodurans

    Science.gov (United States)

    Farci, Domenica; Bowler, Matthew W.; Esposito, Francesca; McSweeney, Sean; Tramontano, Enzo; Piano, Dario

    2015-01-01

    The protein DR_2577 is a major Surface layer component of the radio-resistant bacterium Deinococcus radiodurans. In the present study DR_2577 has been purified and its oligomeric profile characterized by means of size exclusion chromatography and gel electrophoresis. DR_2577 was found to be organized into three hierarchical orders characterized by monomers, stable dimers formed by the occurrence of disulfide bonds, and hexamers resulting from a combination of dimers. The structural implications of these findings are discussed providing new elements for a more integrated model of this S-layer. PMID:26074883

  11. Scattered regulatory regions of the chicken immunoglobulin-β gene and two adjacent promoters of ubiquitously expressed genes interact with the immunoglobulin-β promoter in DT40 cells.

    Science.gov (United States)

    Minbuta, Tomohiro; Ono, Masao

    2011-01-01

    Recent studies indicate that several transcription units assemble to form a 'transcription factory' where active transcription occurs in the nuclei. Previously, we generated chicken B-lymphocyte-derived DT40 cells lacking six transcriptional regulatory regions scattered in and around the immunoglobulin (Ig)-β gene. The deletions caused a complete shut down of transcription and epigenetic regulation of the Ig-β gene, demonstrating that the scattered regulatory regions cooperated in the transcriptional and epigenetic regulation of the gene. However, the in vivo 3-dimensional spatial relationships between the Ig-β promoter and these six regulatory regions were not investigated. In this study, we used chromosome conformation capture (3C) technology and demonstrated that the Ig-β promoter physically interacted with the scattered regulatory regions. We found that the Ig-β promoter also interacted with two downstream promoters of ubiquitously expressed genes, rad motif 1 (RDM1) and Plekhm1, to form a transcription factory, but not with three ubiquitously expressed genes, BAF60b, p45/SUG, and RRMJ3, located upstream of the Ig-β gene. In this factory, the chromatin from the three promoters and the scattered regulatory regions of the Ig-β gene formed a complex structure with many chromatin loops.

  12. 半空间中次调和函数的Phragmén-Lindel(o)f定理及应用%Phragmén-Lindel(o)f theorems of subharmonic functions and their applications in the Half space

    Institute of Scientific and Technical Information of China (English)

    张艳慧

    2015-01-01

    本文利用调和函数的Carleman公式,结合Levi的方法,在半空间中证明了次调和函数的Phragmén-Lindel(o)f定理.作为Phragmén-Lindel(o)f定理的应用,本文引入了半空间中的C类函数,并且得到了次调和函数属于C类函数的一个充分必要条件,从而推广了Ahlfors和Levi等的经典结果.

  13. PMN-PT夹层弹性半空间结构中 SH 波的传播%Propagation of SH waves in sandwich structures consisting of PMN-PT single crystal layer and elastic half-spaces

    Institute of Scientific and Technical Information of China (English)

    孔艳平; 聂国权; 刘金喜

    2016-01-01

    The propagation of SH waves in a sandwich structure consisting of a PMN‐PT single crystal layer and two different elastic half‐spaces is analytically investigated .The PMN‐PT piezoelectric crystals are being polarized along [011 ]c of the cubic reference directions so that the effective macroscopic symmetries is mm2 .T he cutting angle of the PM N‐PT single crystal isθ.Based on the basic equations of the orthotropic piezoelectric material and elastic material ,the dispersion equations are obtained in determinant form by interface continuous conditions .T he numerical examples are presented to show that the phase velocity is sensitive to the cutting angle of the PMN‐PT and the material properties .The results of the paper are useful and important for surface acoustic wave devices .%分析了弹性上下半空间和PMN‐PT单晶层组成的夹层结构中SH波的传播性质,PMN‐PT单晶沿[011]c方向极化,宏观上呈mm2对称,且晶体沿角度θ方向切割。基于正交各向异性压电材料和各向同性弹性材料的基本方程,得到了夹层结构中SH波传播时行列式形式的频散方程。通过对数值算例进行分析可以看出,PMN‐PT单晶的切割角度和弹性材料属性对结构中的相速度有很大影响,因此波的某些传播性能可以通过材料的设计以及晶体切割的方向来实现,这些结论为声表面波器件的开发和应用提供了理论依据。

  14. 四元数半空间中的次调和函数及其等价性质%The equivalent properties of subharmonic functions in quaternion half space

    Institute of Scientific and Technical Information of China (English)

    张艳慧; 邓冠铁; 杨康莉

    2015-01-01

    研究四元数半空间中的次调和函数,借助于复分析和调和分析给出了四元数次调和函数的性质及其等价条件;从而改进了四元数半空间中四元数次调和函数的某些经典结果。%Subharmonic function of quaternionic variables is examined,together with its applications. Fundamental complex analytic and harmonic analytic notions are used to present the properties and equalisation conditions of quaternionic subharmonic functions This will provide generalizations of analogous complex analytic applications and harmonic analytic applications and improve the classical result on quaternionic subharmonic function in quaternionic half place.

  15. 正交各向异性弹性层/压磁半空间结构中Love波的传播%PROPAGATION OF LOVE WAVES IN AN ORTHOTROPIC ELASTIC LAYER/PIEZOMAGNETIC HALF SPACE

    Institute of Scientific and Technical Information of China (English)

    孔艳平; 岳鹏阳; 刘金喜

    2013-01-01

    分析了正交各向异性弹性层/压磁半空间结构中Love波的传播特性,得到了Love波传播时的解析解,基于推导的频散方程,数值分析了正交各向异性层的切割角度对Love波频散关系的影响,结果显示相速度对切割角度有很大的依赖性.

  16. Propagation Characteristics of Love Waves in Piezoelectric Half-space with Orthotropic Layer%正交各向异性弹性层/压电半空间结构中Love波的传播特性

    Institute of Scientific and Technical Information of China (English)

    王艳红; 刘金喜

    2008-01-01

    研究了层状半空间介质中Love波的传播特性,其中表面层为正交各向异性纯弹性材料,而半空间为横观各向同性压电材料.推导了显函形式的频散方程,并结合数值算例分析了压电材料的性能和正交各向异性的程度对传播速度的影响.

  17. Perancangan Tempat Kerja Dengan Pendekatan Ergonomi Dan SLP (Systematic Layout Planning) Untuk Meningkatkan Produktivitas Pada Proses Produksi Sapu Lidi Hias Di CV. Chantiqa Handycraft

    OpenAIRE

    Hasibuan, Yetti Meuthia

    2010-01-01

    CV Chantiqa Handicraft is one of the small industrial sector engaged in processing agricultural waste such as eceng gondok, pandan duri, batok kelapa, pelepah daun kelapa sawit to the various household furnishings and decorations like a soap, baskets mats, tables, chairs and “sapu lidi hias”. As a local company a simple, CV Chantiqa Handicraft production process at a workplace that is not centralized causing transportation back tracking so that when the transportation is going to be great. ...

  18. CAMBIO CLIMÁTICO Y DESARROLLO SUSTENTABLE EN LA HUASTECA POTOSINA. EL CASO DEL CORREDOR ECO TURÍSTICO INDÍGENA TAMUÍN, S.L.P.

    Directory of Open Access Journals (Sweden)

    Alfonso Muñoz Güemes

    2013-06-01

    Full Text Available El desarrollo económico, social y humano entre los diferentes grupos étnicos que habitan en la región Huasteca de San Luis potosí, se ha caracterizado por una gran deficiencia en las políticas públicas que generen un modelo de generación de riqueza social equitativa para estos sectores. Por otra parte, las actividades económicas, fundamentalmente en el sector primario de la economía regional, son altamente contaminantes y destructoras del medio ambiente, a la vez que son deficitarias en términos de la competitividad comercial y su generación del PIB.En este orden de ideas, el turismo alternativo, con sus diversificaciones hacia el turismo rural, el ecológico, el etnográfico, entre otras modalidades, se convierte en un nuevo paradigma de desarrollo endógeno que pudiera ser la respuesta para alcanzar el desarrollo social equitativo, con respeto hacia el entorno ecológico y promotor de riqueza social auto gestionada.

  19. Evaluación de la contaminación por metales en pasivos ambientales de actividades metalúrgicas históricas en el distrito minero Cerro de San Pedro, S.L.P. (México)

    OpenAIRE

    Rodríguez y Rodríguez, Yolanda

    2011-01-01

    Pasivos ambientales minero-metalúrgicos son frecuentemente encontrados en regiones donde estas actividades se han desarrollado históricamente, como es el caso del Estado de San Luis Potosí, en donde desde el siglo XVI han existido importantes centros mineros, destacando entre ellos el Distrito Minero de Cerro de San Pedro que se localiza en la porción centro-sur del Estado, 19.5 kilómetros al NW de la ciudad de San Luis Potosí. La situación geográfica del sitio donde se descubriero...

  20. 基于SLP的舰船膳食系统布置优化研究%Optimization research of dietary system facility layout of ship based on SLP method

    Institute of Scientific and Technical Information of China (English)

    张祥瑞

    2015-01-01

     为降低舰船膳食系统作业成本,提高作业效率,文章以物料移动距离最小为目标,利用系统设计布置法(SLP)优化舰船膳食系统布置。通过分析系统内部各个作业单位间的物流与非物流相关关系,得到最优布置方案,并用Flexsim仿真软件对该方案进行仿真评价,验证其实用性及有效性。结果表明,该布置方案能有效降低物流成本,提高作业效率。%To decrease the operation cost of dietary system of ship and increase operation effciency, systematic layout planning method was used to optimize the dietary system facility layout aiming at achieving the least transport amount. Integrating the logistic and non-logistic relationships of the operation unit, an optimal project of facility layout was obtained. And then Flexsim simulation model was used to check the practicality and effciency of the project. The result indicated that the optimal project can decrease logistic cost validly and increase operation effciency obviously.

  1. Study on Warehouse Layout Planning of Company C Based on Improved SLP%基于改进型SLP方法的C公司仓库布局规划研究

    Institute of Scientific and Technical Information of China (English)

    汪学勤; 徐杰

    2016-01-01

    In this paper, in view of the problems in the layout of the newly leased warehouse of a company C and through reviewing relevant literatures, we analyzed in detail the characteristics of the orders and products of the warehouse, studied the interrelationship between the functional zones using the two indexes namely order volume and cargo volume, and then verified the influence of the two on the relationships between the comprehensive functional zones to derive the final layout plan.%针对C公司新租赁仓库在布局中存在主观性强、功能区域布置不合理、仓库作业路径杂乱等现象,通过查阅相关仓库布局文献,借鉴改进型SLP方法,结合企业实际业务情况和仓库存在的问题,详细分析仓库订单业务的特点,按订单量和货物量两个指标分析了功能区域间的相互关系,并验证订单量和货物量对综合功能区域间相互关系的影响,形成最终布局方案.

  2. Voz do professor: uma revisão de 15 anos de contribuição fonoaudiológica Teachers' voice: a review of 15 years of SLP contribution

    Directory of Open Access Journals (Sweden)

    Maria Lúcia Suzigan Dragone

    2010-01-01

    Full Text Available O objetivo deste artigo foi realizar uma revisão das publicações brasileiras referentes à voz do professor, produzidas por fonoaudiólogos, no período de 1994 a 2008. O estudo transversal, de natureza bibliográfica, foi realizado em três etapas. A primeira constou de levantamento em diferentes fontes; a segunda compreendeu a busca dos resumos de todos os trabalhos relacionados; na terceira, foi realizada leitura do material para classificação em quatro categorias: avaliação dos indivíduos; avaliação dos efeitos de intervenções; descrição de intervenções; e estudos bibliográficos/teóricos/documentais. Foram contabilizadas 500 publicações, sendo 415 (83% referentes às categorias de avaliações e, dentre essas, 357 (86% com objetivo de avaliação dos participantes e/ou das condições de trabalho e apenas 58 (14% com preocupação de avaliar os efeitos de programas/intervenções. Quanto às dimensões de análise das avaliações, que em 202 estudos (48,7% foram mais de uma, a perspectiva dos próprios professores foi a mais utilizada (52,5% das análises, seguida por análises perceptivo-auditivas realizadas por fonoaudiólogos (15,2%, e avaliação do ambiente e da organização do trabalho (14,9%. Na categoria denominada descritivos de intervenção foram encontrados 31 (6,2% trabalhos e na categoria bibliográfico/teórico/documental, 54 (10,8%. A revisão realizada confirma que a perspectiva da avaliação vocal tem sido privilegiada nos estudos brasileiros. Avaliações de efeito de intervenções, mais recentes e ainda pouco representativas, indicam uma tendência de mudança de foco que pode auxiliar a compreensão da complexa realidade do uso da voz na docência, nortear futuras ações fonoaudiológicas e inspirar estudos sobre intervenção fonoaudiológica com esses indivíduos.The purpose of this study was to review Brazilian publication regarding teachers' voice produced by Speech-Language Pathologists (SLPs within the period from 1994 to 2008. This transversal study of bibliographic nature was carried out in three stages. The first consisted of data compilation from different sources; the second comprehended the search for the abstracts of the selected references; in the third stage, the publications were classified into four categories: individuals' assessment, treatment outcome evaluation, intervention description, and bibliographical/theoretical/documental researches. The final sample consisted of 500 publications, from which 415 (83% were related to the assessment categories. Among these, 357 (86% evaluated individuals and/or their working conditions, and 58 (14% had the aim to evaluate treatment outcome. Regarding analyses dimensions of the assessments, 202 studies (48.7% had more than one. Teachers' perspective (self-assessment was the predominant dimension (52.5% of the analyses, followed by auditory-perceptual analyses performed by SLPs (15.2%, and evaluation of working environment and organization (14.9%. The category intervention description had 31 (6.2% studies, and there were 54 (10.8% bibliographical/theoretical/documental researches. This literature review confirms that vocal assessment has been privileged in Brazilian researches regarding teachers' voice. Publications about treatment outcome evaluations are more recent and less representative, indicating a tendency of change of focus that might help the comprehension of the complex use of voice in teaching, and guide future studies on speech-language pathology intervention with these individuals.

  3. CAMBIO CLIMÁTICO Y DESARROLLO SUSTENTABLE EN LA HUASTECA POTOSINA. EL CASO DEL CORREDOR ECO TURÍSTICO INDÍGENA TAMUÍN, S.L.P.

    OpenAIRE

    Alfonso Muñoz Güemes

    2013-01-01

    El desarrollo económico, social y humano entre los diferentes grupos étnicos que habitan en la región Huasteca de San Luis potosí, se ha caracterizado por una gran deficiencia en las políticas públicas que generen un modelo de generación de riqueza social equitativa para estos sectores. Por otra parte, las actividades económicas, fundamentalmente en el sector primario de la economía regional, son altamente contaminantes y destructoras del medio ambiente, a la vez que son deficitarias en térmi...

  4. Tidal breathing parameters measured using structured light plethysmography in healthy children and those with asthma before and after bronchodilator.

    Science.gov (United States)

    Hmeidi, Hamzah; Motamedi-Fakhr, Shayan; Chadwick, Edward; Gilchrist, Francis J; Lenney, Warren; Iles, Richard; Wilson, Rachel C; Alexander, John

    2017-03-01

    Structured light plethysmography (SLP) is a light-based, noncontact technique that measures tidal breathing by monitoring displacements of the thoracoabdominal (TA) wall. We used SLP to measure tidal breathing parameters and their within-subject variability (v) in 30 children aged 7-16 years with asthma and abnormal spirometry (forced expiratory volume in 1 sec [FEV1] displacement ratio (IE50SLP, calculated as TIF50SLP/TEF50SLP, where TIF50SLP is tidal inspiratory TA displacement rate at 50% of inspiratory displacement and TEF50SLP is tidal expiratory TA displacement rate at 50% of expiratory displacement). Median (m) IE50SLP and its variability (vIE50SLP) were both higher in children with asthma (prebronchodilator) compared with healthy children (mIE50SLP: 1.53 vs. 1.22, P < 0.001; vIE50SLP: 0.63 vs. 0.47, P < 0.001). After administration of bronchodilators to the asthma group, mIE50SLP decreased from 1.53 to 1.45 (P = 0.01) and vIE50SLP decreased from 0.63 to 0.60 (P = 0.04). SLP-measured tidal breathing parameters could differentiate between children with and without asthma and indicate a response to bronchodilator.

  5. Speech for People with Tracheostomies or Ventilators

    Science.gov (United States)

    ... SLP will evaluate the person's thinking and language skills, oral-motor and swallowing functioning, and ability to produce voice in different situations. Whatever communication method is recommended for the person, the SLP ...

  6. Interchange of the active and silent S-layer protein genes of Lactobacillus acidophilus by inversion of the chromosomal sip segment

    NARCIS (Netherlands)

    Boot, H.J.; Kolen, C.P.A.M.; Pouwels, P.H.

    1996-01-01

    The most-dominant surface-exposed protein in many bacterial species is the S-protein. This protein crystallises into a regular monolayer on the outside surface of the bacteria: the S-layer. Lactobacillus acidophilus harbours two S-protein-encoding genes, slpA and slpB, only one of which (slpA) is ex

  7. Stuttering attitudes of students: Professional, intracultural, and international comparisons.

    Science.gov (United States)

    St Louis, Kenneth O; Przepiorka, Aneta M; Beste-Guldborg, Ann; Williams, Mandy J; Blachnio, Agata; Guendouzi, Jacqueline; Reichel, Isabella K; Ware, Mercedes B

    2014-03-01

    The study sought to identify major-specific, training, and cultural factors affecting attitudes toward stuttering of speech-language pathology (SLP) students. Eight convenience samples of 50 students each from universities in the USA and Poland filled out the Public Opinion Survey of Human Attributes-Stuttering (POSHA-S) in English or Polish, respectively. USA samples included undergraduate and graduate students in SLP majors or non-SLP majors as well as a sample of non-SLP students who were Native Americans. Polish samples included SLP (logopedics), psychology, and mixed majors. SLP students held more positive attitudes than non-SLP students in both countries. Graduate students held more positive attitudes than undergraduate students in the USA, and this effect was stronger for SLP than for non-SLP students. Native American students' stuttering attitudes were similar to other American non-SLP students' attitudes. Polish student attitudes were less positive overall than those of their American student counterparts. SLP students' attitudes toward stuttering are affected by a "halo effect" of being in that major, by specific training in fluency disorders, and by various cultural factors, yet to be clearly understood. The reader will be able to: (a) describe major factors affecting SLP students' attitudes toward stuttering; (b) describe similarities and differences in attitudes toward stuttering of students from the USA and Poland; (c) describe similarities and differences in attitudes toward stuttering of Native American students from the USA and non-Native American students. Copyright © 2013 Elsevier Inc. All rights reserved.

  8. 78 FR 48526 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2013-08-08

    ... based on the SLP's level of quoting and the average daily volume (``ADV'') of liquidity added by the SLP in assigned securities, excluding early closing days for the ADV calculation. \\3\\ The SLP program provides incentives for quoting and adds competition to the existing group of liquidity providers. An...

  9. 77 FR 33203 - Notice of Submission for OMB Review; Office of Innovation and Improvement; School Leadership...

    Science.gov (United States)

    2012-06-05

    ... Notice of Submission for OMB Review; Office of Innovation and Improvement; School Leadership Program (SLP) Annual Performance Report SUMMARY: The School Leadership Program (SLP) provides grants to assist high... records. Title of Collection: School Leadership Program (SLP) Annual Performance Report. OMB...

  10. Low Reynolds number flow across an array of cylindrical microposts in a microchannel and figure-of-merit analysis of micropost-filled microreactors

    Science.gov (United States)

    Yeom, J.; Agonafer, D. D.; Han, J.-H.; Shannon, M. A.

    2009-06-01

    Micropost-filled reactors are commonly found in many micro-total analysis system applications because of their large surface area for the surrounding volume. Design rules for micropost-filled reactors are presented here to optimize the performance of a micro-preconcentrator, which is a component of a micro-gas chromatography system. A key figure of merit for the performance of the micropost-filled preconcentrator is to minimize the pressure drop while maximizing the surface-area-to-volume ratio for a given overall channel geometry. Several independent models from the literature are used to predict the flow resistance across the micropost-filled channels for low Reynolds number flows. The pressure drop can be expressed solely as a function of a couple of design parameters: β = a/s, the ratio of the radius of each post to the half-spacing between two adjacent posts, and N, the number of microposts in a row. Pressure drop measurements are performed to experimentally corroborate the flow resistance models and the optimization scheme using the figure of merit. As the number of microposts for a given β increases in a given channel size, a greater surface-area-to-volume ratio will result for a fixed pressure drop. Therefore, increasing the arrays of posts with smaller diameters and spacing will optimize the microreactor for larger surface area for a given flow resistance, at least until Knudsen flow begins to dominate.

  11. Role of S-layer proteins in the biosorption capacity of lead by Lactobacillus kefir.

    Science.gov (United States)

    Gerbino, Esteban; Carasi, Paula; Araujo-Andrade, Cuauhtémoc; Tymczyszyn, E Elizabeth; Gómez-Zavaglia, Andrea

    2015-04-01

    The role of S-layer proteins (SLP) on the Pb(2+) sequestrant capacity by Lactobacillus kefir CIDCA 8348 and JCM 5818 was investigated. Cultures in the stationary phase were treated with proteinase K. A dot blot assay was carried out to assess the removal of SLP. Strains with and without SLP were exposed to 0-0.5 mM Pb(NO3)2. The maximum binding capacity (q max ) and the affinity coefficient (b) were calculated using the Langmuir equation. The structural effect of Pb(2+) on microorganisms with and without SLP was determined using Raman spectroscopy. The bacterial interaction with Pb(2+) led to a broadening in the phosphate bands (1,300-1,200 cm(-1) region) and strong alterations on amide and carboxylate-related bands (νCOO(-) as and νCOO(-) s). Microorganisms without SLP removed higher percentages of Pb(2+) and had higher q max than those bearing SLP. Isolated SLP had much lower q max and also removed lower percentages of Pb(2+) than the corresponding whole microorganisms. The hydrofobicity of both strains dramatically dropped when removing SLP. When bearing SLP, strains do not expose a large amount of charged groups on their surfaces, thus making less efficient the Pb(2+) removal. On the contrary, the extremely low hydrofobicity of microorganisms without SLP (and consequently, their higher capacity to remove Pb(2+)) can be explained on the basis of a greater exposure of charged chemical groups for the interaction with Pb(2+). The viability of bacteria without SLP was not significantly lower than that of bacteria bearing SLP. However, microorganisms without SLP were more prone to the detrimental effect of Pb(2+), thus suggesting that SLP acts as a protective rather than as a sequestrant layer.

  12. Characterization of a S-layer protein from Lactobacillus crispatus K313 and the domains responsible for binding to cell wall and adherence to collagen.

    Science.gov (United States)

    Sun, Zhilan; Kong, Jian; Hu, Shumin; Kong, Wentao; Lu, Wenwei; Liu, Wei

    2013-03-01

    It was previously shown that the surface (S)-layer proteins covering the cell surface of Lactobacillus crispatus K313 were involved in the adherence of this strain to human intestinal cell line HT-29. To further elucidate the structures and functions of S-layers, three putative S-layer protein genes (slpA, slpB, and slpC) of L. crispatus K313 were amplified by PCR, sequenced, and characterized in detail. Quantitative real-time PCR analysis reveals that slpA was silent under the tested conditions; whereas slpB and slpC, the putative amino acid sequences which exhibited minor similarities to the previously reported S-layer proteins in L. crispatus, were actively expressed. slpB, which was predominantly expressed in L. crispatus K313, was further investigated for its functional domains. Genetic truncation of the untranslated leader sequence (UTLS) of slpB results in a reduction in protein production, indicating that the UTLS contributed to the efficient S-layer protein expression. By producing a set of N- and C-terminally truncated recombinant SlpB proteins in Escherichia coli, the cell wall-binding region was mapped to the C terminus, where rSlpB(380-501) was sufficient for binding to isolated cell wall fragments. Moreover, the binding ability of the C terminus was variable among the Lactobacillus species (S-layer- and non-S-layer-producing strains), and teichoic acid may be acting as the receptor of SlpB. To determine the adhesion region of SlpB to extracellular matrix proteins, ELISA was performed. Binding to immobilized types I and IV collagen was observed with the His-SlpB(1-379) peptides, suggesting that the extracellular matrix protein-binding domain was located in the N terminus.

  13. Колебания пьезоэлектрического полупространства с периодической системой электродов Oscillation of Piezoelectric Half-Space with Periodic System of Electrodes

    Directory of Open Access Journals (Sweden)

    Бардзокас Д. И.

    2000-10-01

    Full Text Available Исследуется вопрос о возбуждении волн в пьезоэлектрическом полупространстве с периодической системой электродов, в результате чего показывается, что при определенных условиях колебания локализуются у его поверхности.

  14. Тоннелирование сдвиговых волн через зазор между двумя магнитострикционными полупространствами Tunnelling of shear waves through gap between two magnetostriction half-spaces

    Directory of Open Access Journals (Sweden)

    Багдасарян Г. Е.

    1989-09-01

    Full Text Available С использованием уравнений и граничных условий магнитоупругости ферромагнитных сред установлена возможность просачивания сдвиговой магнитоупругой волны через зазор между двумя магнитострикционными полупространствами, обусловленная магнитострикционным эффектом.

  15. A Selfish Linear Precoding Strategy for Downlink Two-User MIMO Systems Using Limited Rate Feedback

    Directory of Open Access Journals (Sweden)

    Lei Lv

    2013-07-01

    Full Text Available This letter proposes a limited feedback-based selfish linear precoding (SLP strategy for downlink two-user MIMO systems. In the proposed strategy, each user selfishly chooses the other user’s precoding matrix which minimizes its capacity loss. The proposed SLP strategy has two advantages comparing with traditional linear precoding strategies. First, SLP improves the system capacity by resisting interference more effectively. Second, the computing complexity of transmitter is reduced since the base station needs not to calculate precoding matrix. Simulation results verify the effectiveness of SLP on system capacity improvement comparing to limited feedback block diagonalization (LFBD algorithm, especially when feedback bits are insufficient.

  16. Measurement of retinal nerve fiber layer thickness in eyes with optic disc swelling by using scanning laser polarimetry and optical coherence tomography

    Directory of Open Access Journals (Sweden)

    Hata M

    2013-12-01

    Full Text Available Masayuki Hata, Kazuaki Miyamoto, Akio Oishi, Yugo Kimura, Satoko Nakagawa, Takahiro Horii, Nagahisa Yoshimura Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan Background: The retinal nerve fiber layer thickness (RNFLT in patients with optic disc swelling of different etiologies was compared using scanning laser polarimetry (SLP and spectral-domain optical coherence tomography (OCT. Methods: Forty-seven patients with optic disc swelling participated in the cross-sectional study. Both GDx SLP (enhanced corneal compensation and Spectralis spectral-domain OCT measurements of RNFLT were made in 19 eyes with papilledema (PE, ten eyes with optic neuritis (ON, and 18 eyes with nonarteritic anterior ischemic optic neuropathy (NAION at the neuro-ophthalmology clinic at Kyoto University Hospital. Differences in SLP (SLP-RNFLT and OCT (OCT-RNFLT measurements among different etiologies were investigated. Results: No statistical differences in average OCT-RNFLT among PE, ON, and NAION patients were noted. Average SLP-RNFLT in NAION patients was smaller than in PE (P<0.01 or ON (P=0.02 patients. When RNFLT in each retinal quadrant was compared, no difference among etiologies was noted on OCT, but on SLP, the superior quadrant was thinner in NAION than in PE (P<0.001 or ON (P=0.001 patients. Compared with age-adjusted normative data of SLP-RNFLT, average SLP-RNFLT in PE (P<0.01 and ON (P<0.01 patients was greater. Superior SLP-RNFLT in NAION patients was smaller (P=0.026. The ratio of average SLP-RNFLT to average OCT-RNFLT was smaller in NAION than in PE (P=0.001 patients. Conclusion: In the setting of RNFL thickening, despite increased light retardance in PE and ON eyes, SLP revealed that NAION eyes have less retardance, possibly associated with ischemic axonal loss. Keywords: optic disc swelling, scanning laser polarimetry, optical coherence tomography

  17. Measurement of retinal nerve fiber layer thickness in eyes with optic disc swelling by using scanning laser polarimetry and optical coherence tomography.

    Science.gov (United States)

    Hata, Masayuki; Miyamoto, Kazuaki; Oishi, Akio; Kimura, Yugo; Nakagawa, Satoko; Horii, Takahiro; Yoshimura, Nagahisa

    2014-01-01

    The retinal nerve fiber layer thickness (RNFLT) in patients with optic disc swelling of different etiologies was compared using scanning laser polarimetry (SLP) and spectral-domain optical coherence tomography (OCT). Forty-seven patients with optic disc swelling participated in the cross-sectional study. Both GDx SLP (enhanced corneal compensation) and Spectralis spectral-domain OCT measurements of RNFLT were made in 19 eyes with papilledema (PE), ten eyes with optic neuritis (ON), and 18 eyes with nonarteritic anterior ischemic optic neuropathy (NAION) at the neuro-ophthalmology clinic at Kyoto University Hospital. Differences in SLP (SLP-RNFLT) and OCT (OCT-RNFLT) measurements among different etiologies were investigated. No statistical differences in average OCT-RNFLT among PE, ON, and NAION patients were noted. Average SLP-RNFLT in NAION patients was smaller than in PE (P<0.01) or ON (P=0.02) patients. When RNFLT in each retinal quadrant was compared, no difference among etiologies was noted on OCT, but on SLP, the superior quadrant was thinner in NAION than in PE (P<0.001) or ON (P=0.001) patients. Compared with age-adjusted normative data of SLP-RNFLT, average SLP-RNFLT in PE (P<0.01) and ON (P<0.01) patients was greater. Superior SLP-RNFLT in NAION patients was smaller (P=0.026). The ratio of average SLP-RNFLT to average OCT-RNFLT was smaller in NAION than in PE (P=0.001) patients. In the setting of RNFL thickening, despite increased light retardance in PE and ON eyes, SLP revealed that NAION eyes have less retardance, possibly associated with ischemic axonal loss.

  18. Glaucoma progression detection by retinal nerve fiber layer measurement using scanning laser polarimetry: event and trend analysis.

    Science.gov (United States)

    Moon, Byung Gil; Sung, Kyung Rim; Cho, Jung Woo; Kang, Sung Yong; Yun, Sung-Cheol; Na, Jung Hwa; Lee, Youngrok; Kook, Michael S

    2012-06-01

    To evaluate the use of scanning laser polarimetry (SLP, GDx VCC) to measure the retinal nerve fiber layer (RNFL) thickness in order to evaluate the progression of glaucoma. Test-retest measurement variability was determined in 47 glaucomatous eyes. One eye each from 152 glaucomatous patients with at least 4 years of follow-up was enrolled. Visual field (VF) loss progression was determined by both event analysis (EA, Humphrey guided progression analysis) and trend analysis (TA, linear regression analysis of the visual field index). SLP progression was defined as a reduction of RNFL exceeding the predetermined repeatability coefficient in three consecutive exams, as compared to the baseline measure (EA). The slope of RNFL thickness change over time was determined by linear regression analysis (TA). Twenty-two eyes (14.5%) progressed according to the VF EA, 16 (10.5%) by VF TA, 37 (24.3%) by SLP EA and 19 (12.5%) by SLP TA. Agreement between VF and SLP progression was poor in both EA and TA (VF EA vs. SLP EA, k = 0.110; VF TA vs. SLP TA, k = 0.129). The mean (±standard deviation) progression rate of RNFL thickness as measured by SLP TA did not significantly differ between VF EA progressors and non-progressors (-0.224 ± 0.148 µm/yr vs. -0.218 ± 0.151 µm/yr, p = 0.874). SLP TA and EA showed similar levels of sensitivity when VF progression was considered as the reference standard. RNFL thickness as measurement by SLP was shown to be capable of detecting glaucoma progression. Both EA and TA of SLP showed poor agreement with VF outcomes in detecting glaucoma progression.

  19. On the Complexity of Numerical Analysis

    DEFF Research Database (Denmark)

    Allender, Eric; Bürgisser, Peter; Kjeldgaard-Pedersen, Johan;

    2005-01-01

    an integer N, decide whether N>0. We show that PosSLP lies in the counting hierarchy, and we show that if A is any language in the Boolean part of Polynomial-time over the Reals accepted by a machine whose machine constants are algebraic real numbers, then A is in P^PosSLP. Combining our results with work...

  20. A novel non-mineral oil-based adjuvant. II. Efficacy of a synthetic sulfolipopolysaccharide in a squalane-in-water emulsion in pigs

    NARCIS (Netherlands)

    L.A.Th. Hilgers (L. A Th); P.L.I. Platenburg (P. L I); A. Luitjens (A.); B. Groenveld (B.); T. Dazelle (T.); J.T.M. Weststrate

    1994-01-01

    textabstractThe adjuvanticity of a sulfolipopolysaccharide (SLP) incorporated into a squalane-in-water emulsion (SLP/S/W) was compared with that of a mineral oil-in-water (O/W) adjuvant currently used in commercial porcine vaccines. Groups of pigs were immunized twice with vaccines comprising either

  1. The S-layer gene of Lactobacillus helveticus CNRZ 892 : cloning, sequence and heterologous expression

    NARCIS (Netherlands)

    Callegari, M.L.; Riboli, B.; Sanders, J.W; Cocconcelli, P.S.; Kok, J.; Venema, G; Morelli, L.

    1998-01-01

    Lactobacillus helveticus CNRZ 892 contains a surface layer (S-layer) composed of protein monomers of 43 kDa organized in regular arrays. The gene encoding this protein (slpH) has been cloned in Escherichia coli and sequenced. slpH consists of 440 codons and is preceded by a ribosome-binding site (RB

  2. Use of dynamic membranes for the preparation of vitamin E-loaded lipid particles: An alternative to prevent fouling observed in classical cross-flow emulsification

    NARCIS (Netherlands)

    Lauoini, A.; Charcosset, C.; Fessi, H.; Schroën, C.G.P.H.

    2014-01-01

    Solid lipid particles (SLP) were introduced at the beginning of the 1990s as an alternative to encapsulation systems such as emulsions and liposomes used in cosmetic and pharmaceutical preparations. The present paper investigated for the first time the preparation of SLP based on premix emulsificati

  3. 75 FR 69125 - Certain Seamless Carbon and Alloy Steel Standard, Line, and Pressure Pipe From China

    Science.gov (United States)

    2010-11-10

    ... COMMISSION Certain Seamless Carbon and Alloy Steel Standard, Line, and Pressure Pipe From China Determination... alloy steel standard, line, and pressure pipe (``seamless SLP pipe''), provided for in subheadings 7304... Charlotte R. Lane determines that the domestic seamless SLP pipe industry is materially injured by reason of...

  4. 77 FR 45388 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2012-07-31

    ... To Extend the Operation of the SLP Pilot The NYSE established the SLP Pilot to provide incentives for... larger orders more efficiently and operates to reward aggressive liquidity providers. As such, the... to encourage the addition of liquidity and operates to reward aggressive liquidity providers...

  5. Stomatin-like protein 2 overexpression in papillary thyroid carcinoma is significantly associated with high-risk clinicopathological parameters and BRAFV600E mutation.

    Science.gov (United States)

    Bartolome, Aleksandar; Boskovic, Srdjan; Paunovic, Ivan; Bozic, Vesna; Cvejic, Dubravka

    2016-04-01

    Stomatin-like protein 2 (SLP-2), a member of the stomatin protein family, has emerged as a potential molecular hallmark of tumor progression in several human malignancies. The aim of this study was to analyze SLP-2 expression pattern in benign and malignant thyroid tumors (n = 210) and to examine its relationship with clinicopathological parameters and BRAFV600E mutation in thyroid cancer. SLP-2 immunohistochemical expression was not detected in benign adenomas and was absent/weak in follicular and anaplastic carcinomas. High expression levels of SLP-2, found only in papillary thyroid carcinoma (PTC), particularly in the classical variant, were significantly associated with adverse clinicopathological parameters: lymph node metastasis (p = 0.002), extrathyroid invasion (p < 0.001), pT status (p < 0.001), and advanced tumor stage (p = 0.001). Additional genotyping of PTC cases for the BRAFV600E mutation revealed for the first time a close relation between SLP-2 overexpression and the presence of BRAF mutation (p = 0.02) with high positive rates of lymph node metastasis (70%) and extrathyroid invasion (80%) in these cases. The significant association of SLP-2 overexpression with unfavorable clinicopathological characteristics and BRAFV600E mutation indicates that SLP-2 may have a role in aggressiveness of BRAF-mutated PTC and that SLP-2 evaluation could be clinically useful in identification of high-risk PTC patients.

  6. Evidence for Whom? ASHA's National Outcomes Measurement System

    Science.gov (United States)

    Mullen, Robert

    2004-01-01

    The growth of managed care and increasing demands by school systems resulted in of a number of new audiences looking for the evidence underlying the practice of speech-language pathology (SLP). Third-party payers, operating in an environment emphasizing ''return-on-investment,'' sought data linking expenditures on SLP services with tangible…

  7. Development and implementation of the Saskatchewan Leadership Program: Leading for healthcare transformation.

    Science.gov (United States)

    Mutwiri, Betty; Witt, Christine; Denysek, Christina; Halferdahl, Susan; McLeod, Katherine M

    2016-01-01

    The Saskatchewan Leadership Program (SLP) was developed based on the LEADS framework and aligned with Lean management to build leadership renewal and sustainability conducive to transformational change in the Saskatchewan health system. This article describes the development, implementation, and evaluation of the SLP, including experiences and lessons learned.

  8. SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis.

    Science.gov (United States)

    Lightfoot, Yaíma L; Selle, Kurt; Yang, Tao; Goh, Yong Jun; Sahay, Bikash; Zadeh, Mojgan; Owen, Jennifer L; Colliou, Natacha; Li, Eric; Johannssen, Timo; Lepenies, Bernd; Klaenhammer, Todd R; Mohamadzadeh, Mansour

    2015-04-01

    Intestinal immune regulatory signals govern gut homeostasis. Breakdown of such regulatory mechanisms may result in inflammatory bowel disease (IBD). Lactobacillus acidophilus contains unique surface layer proteins (Slps), including SlpA, SlpB, SlpX, and lipoteichoic acid (LTA), which interact with pattern recognition receptors to mobilize immune responses. Here, to elucidate the role of SlpA in protective immune regulation, the NCK2187 strain, which solely expresses SlpA, was generated. NCK2187 and its purified SlpA bind to the C-type lectin SIGNR3 to exert regulatory signals that result in mitigation of colitis, maintenance of healthy gastrointestinal microbiota, and protected gut mucosal barrier function. However, such protection was not observed in Signr3(-/-) mice, suggesting that the SlpA/SIGNR3 interaction plays a key regulatory role in colitis. Our work presents critical insights into SlpA/SIGNR3-induced responses that are integral to the potential development of novel biological therapies for autoinflammatory diseases, including IBD.

  9. Science Literacy in School and Home Contexts: Kindergarteners' Science Achievement and Motivation

    Science.gov (United States)

    Mantzicopoulos, Panayota; Patrick, Helen; Samarapungavan, Ala

    2013-01-01

    We examined science learning and motivation outcomes as a function of children's participation in the classroom and classroom-plus-home components of the Scientific Literacy Project (SLP). The sample was comprised of kindergarten children in 4 low income, neighboring schools. Children in Schools 1 and 2 (n = 120) participated in the SLP science…

  10. The Perceived Importance of Anatomy and Neuroanatomy in the Practice of Speech-Language Pathology

    Science.gov (United States)

    Martin, Kate; Bessell, Nicola J.; Scholten, Ingrid

    2013-01-01

    The purpose of this study was to examine the application of anatomy and neuroanatomy knowledge to current practice of speech-language pathology (SLP), based on the perceptions of practicing SLPs, and to elicit information on participants' experiences of learning these subjects in their primary SLP degree with a view to inform potential…

  11. Childhood Apraxia of Speech Family Start Guide

    Science.gov (United States)

    ... is right for every child with apraxia of speech. Commercial products, programs, apps or kits can be […] Read More What To Look for In an SLP for Your Child In the United States, speech-language pathologists (SLP) are certified by the American ...

  12. 嵌入数据结构信息的单类支持向量机及其线性规划算法%Embedding Target Data's Structural Distribution Information into One-Class SVM and Its Linear Programming Algorithm

    Institute of Scientific and Technical Information of China (English)

    冯爱民; 刘学军; 孙廷凯

    2009-01-01

    针对现有基于超平面的单类分类器未同时考虑目标数据全局与局部信息的不足,通过在单类支持向量机One-Class SVM(OCSVM)算法中加入类内散度以反应目标数据的全局信息,提出了结构化单类支持向量机Structured OCSVM(SOCSVM),不仅使之具有全局与局部化学习的特点,同时也为诸多的SVM算法嵌入数据内在结构这类先验信息提供了统一框架.为进一步提高运算效率,在SOCSVM二次规划求解基础上,通过最小化目标数据均值到超平面的函数距离,提出了线性规划算法,同时也避免了SOCSVM必须以原点作为负类代表的不足.人工和真实数据集上的实验结果验证了嵌入目标数据结构信息的SOCSVM及其线性规划算法的有效性.%In order to distinguish the target class from outliers accurately, One-Class Classifier ( OCC) should take into account the prior knowledge of the target class. However, One-Class SVM ( OCSVM), the state-of-the-art OCC, neglects the data's distribution information while finding the optimal hyper-plane. Structured OCSVM (SOCSVM) , the novel proposed OCC, alleviates this problem by embedding the within-class scattered matrix of the target data into OCSVM. As a result, SOCSVM not only overcomes the above disadvantage of the OCSVM, but also provides a unified framework for the present SVM algorithms how to consider intrinsic structure of the data. Moreover, to improve the efficiency of SOCSVM , linear programming algorithm called SlpOCSVM is proposed to instead of the quadratic programming solving for SOCSVM. Through minimizing the functional distance of the data's mean to the hyperplane, the optimal hyperplane is attracted automatically to the place of the minimum positive half space without borrowing the origin as a representative of the outlier anymore . The experiment results on toy problem and real data sets demonstrate the advantage of SOCSVM and its linear programming algorithm.

  13. Knowledge about, attitude toward, and practice of skin lightening products use and its social correlates among university students in five Association of Southeast Asian Nations (ASEAN) countries.

    Science.gov (United States)

    Peltzer, Karl; Pengpid, Supa

    2017-03-01

    The aim of this study was to investigate the knowledge about, attitude toward, and use of skin lightening products (SLP) and its social and psychological correlates among university students from five Association of Southeast Asian Nations (ASEAN) countries. In a cross sectional survey, 3259 undergraduate university students (Mean age = 20.5 years, SD = 1.6) from five ASEAN countries responded to an anonymous questionnaire. Multivariate logistic regression analysis was used to identify associations between sociodemographic characteristics, knowledge, attitude, poor mental health, and SLP use. Overall, 79.1% of the students were aware that the use of SLP can harm the skin, and 30.1% knew the active ingredients of SLP. Most students had a positive perception of having a lighter skin tone and SLP. Overall, the prevalence of SLP use over the past 12 months was 30.7%, 16.7% of male, and 30.0% of female students, ranging from 13.4% in Myanmar to 69.4% in Thailand. In multivariate logistic regression analysis, among women, older age, coming from a poorer family, residing in an upper middle income country, awareness of active skin lightening ingredients, and poor mental health were associated with SLP, while among men, not aware of the negative effects of SLP and awareness of active skin lightening ingredients and poor mental health were associated with SLP use. A high prevalence of SLP use was found in a large sample of ASEAN university students, and several social and mental health-related risk factors were found that may help in guiding interventions. © 2017 The International Society of Dermatology.

  14. Lactobacillus acidophilus CP23 with weak immunomodulatory activity lacks anchoring structure for surface layer protein.

    Science.gov (United States)

    Yanagihara, Sae; Kato, Shinji; Ashida, Nobuhisa; Yamamoto, Naoyuki

    2015-05-01

    To determine the reason for the low levels of Surface layer protein A (SlpA) on CP23 cells, which might play a crucial role in the immunomodulatory effect of Lactobacillus acidophilus, the DNA sequence of the slpA gene of CP23 and L-92 strains, including the upstream region, were analyzed. Unexpectedly, there was no significant difference in the predicted amino acid sequence of the C-terminus needed for cell anchoring, and only an additional Ala-Val-Ala sequence inserted in the N-terminal region of the mature CP23 protein. Therefore, anchoring of SlpA on the cell wall of CP23 and L-92 was evaluated by a reconstitution assay, which showed that SlpA released by LiCl treatment from both CP23 and L-92 was successfully anchored on LiCl-treated L-92 cells, but not on LiCl-treated CP23 cells. Moreover, quantitative analysis of SlpA protein in the culture medium of CP23 and L-92 by ELISA revealed higher levels of SlpA secretion in CP23 cells than in L-92 cells. Collectively, these results suggest that the lower levels of SlpA on the surface of CP23 cells might be caused by less cell wall capacity for SlpA anchoring, leading to an accumulation of SlpA in the culture medium of CP23 cells. The present study supports the importance of cell surface structure of L. acidophilus L-92 for SlpA anchoring on the cell surface needed for immunomodulatory effect.

  15. Antioxidant Activity of Stevia(Stevia rebaudianaL. Leaf Powder and A Commercial Stevioside Powder

    Directory of Open Access Journals (Sweden)

    Galla Narsing Rao

    2014-05-01

    Full Text Available Stevia leaf powder (SLP and a commercial stevioside powder (CSP were analysed for their polyphenol content, isothermal sorption behavior and their antioxidant activity was evaluated by DPPH radical scavenging activity, ferric reducing power and ABTS assay. Polyphenol contents were higher (5.6% in SLP than in CSP (2.3%. It was observed that the SLP was non-hygroscopic and CSP was hygroscopic in nature as seen from sorption isotherms. The equilibrium relative humidity of SLP and CSP respectively was 62 and 24%. The antioxidant activity of the methanolic extracts were determined and DPPH radical scavenging activity for SLP showed 30.33% for 20 µg/ml and 52.46% inhibition at 100 µg/ml, which were slightly higher compared to CSP stevioside, which showed 29.5% and 47.64% inhibition for similar concentrations.Higher ferric reducing power was seen in CSP (0.632 than SLP (0.166 for 100 µg.The antioxidant activity measured by ABTS assay also indicated higher activity (37.5% inhibition for10 µg/ml for SLP than CSP (39.66% for 40 µg/ml.

  16. Validity of conducting clinical dysphagia assessments for patients with normal to mild cognitive impairment via telerehabilitation.

    Science.gov (United States)

    Ward, Elizabeth C; Sharma, Shobha; Burns, Clare; Theodoros, Deborah; Russell, Trevor

    2012-12-01

    To assess the validity of conducting clinical dysphagia assessments via telerehabilitation, 40 individuals with dysphagia from various etiologies were assessed simultaneously by a face-to-face speech-language pathologist (FTF-SLP) and a telerehabilitation SLP (T-SLP) via an Internet-based videoconferencing telerehabilitation system. Dysphagia status was assessed using a Clinical Swallowing Examination (CSE) protocol, delivered via a specialized telerehabilitation videoconferencing system and involving the use of an assistant at the patient's end of the consultation to facilitate the assessment. Levels of agreement between the FTF-SLP and T-SLP revealed that the majority of parameters reached set levels of clinically acceptable levels of agreement. Specifically, agreement between the T-SLP and FTF-SLP ratings for the oral, oromotor, and laryngeal function tasks revealed levels of exact agreement ranging from 75 to 100% (kappa = 0.36-1.0), while the parameters relating to food and fluid trials ranged in exact agreement from 79 to 100% (kappa = 0.61-1.0). Across the parameters related to aspiration risk and clinical management, exact agreement ranged between 79 and 100% (kappa = 0.49-1.0). The data show that a CSE conducted via telerehabilitation can provide valid and reliable outcomes comparable to clinical decisions made in the FTF environment.

  17. Synergistic antibacterial mechanism of the Lactobacillus crispatus surface layer protein and nisin on Staphylococcus saprophyticus.

    Science.gov (United States)

    Sun, Zhilan; Li, Pengpeng; Liu, Fang; Bian, Huan; Wang, Daoying; Wang, Xiaomeng; Zou, Ye; Sun, Chong; Xu, Weimin

    2017-03-21

    SlpB, a surface layer protein isolated from Lactobacillus crispatus, has the potential to enhance the antimicrobial activity of nisin. Previous research indicated that, when combined with nisin, SlpB acted synergistically to inhibit Staphylococcus saprophyticus growth, thus extending the shelf life of chicken meat. In order to understand how SlpB enhances the antibacterial activity of nisin, electron microscopy, confocal laser scanning microscopy, flow cytometry and transmembrane electrical potential analysis were used to study cell wall organization and cell membrane integrity. No remarkable bacteriolytic effects were observed, indicating that cell death could not be attributed to cell lysis, although SlpB caused dramatic modifications of cell wall, thereby altering cell shape. The combination of SlpB and nisin also induced the release of ATP or UV-absorbing materials, as well as sudden dissipation of the transmembrane electrical potential by compromising membrane integrity. Considering that SlpB led to structural disorganization of the cell wall, and nisin access is enhanced to form a stable pore, cell death is a predictable outcome. SlpB significantly enhanced the effect of nisin at half of the minimum inhibitory concentration, which resulted in cell death by destroying the cell wall and cell membrane, therefore providing a new, feasible approach in food preservation.

  18. Scanning laser polarimetry reveals status of RNFL integrity in eyes with optic nerve head swelling by OCT.

    Science.gov (United States)

    Kupersmith, Mark J; Kardon, Randy; Durbin, Mary; Horne, Melissa; Shulman, Julia

    2012-04-18

    Optical coherence tomography (OCT) shows retinal nerve fiber layer (RNFL) thickening in optic nerve head (ONH) swelling, but does not provide information on acute axonal disruption. It was hypothesized that scanning laser polarimetry (SLP) compared with OCT might reveal the status of axon integrity and visual prognosis in acute RNFL swelling. Threshold perimetry, OCT, and SLP were used to prospectively study eyes with papilledema (24), optic neuritis (14), nonarteritic anterior ischemic optic neuropathy (NAION) (21), and ONH swelling (average RNFL value by OCT was above the 95th percentile of controls at presentation). Regional RNFL was judged reduced if the quadrant measurement was below the fifth percentile of controls. At presentation, average RNFL by OCT was similar for eyes with papilledema and NAION (P = 0.97), and reduced for optic neuritis. Average RNFL by SLP was slightly increased for papilledema and optic neuritis, and reduced for NAION (P = 0.02) eyes. The RNFL by SLP was reduced in at least one quadrant in 1 eye with papilledema, 1 eye with optic neuritis, and in 13 eyes with NAION. In NAION eyes, quadrants with reduced SLP had corresponding visual field loss that did not recover. By one month, eyes with NAION showed RNFL thinning by OCT (7/17 eyes) and by SLP (14/16 eyes) in contrast to optic neuritis (by OCT, 0/12, P = 0.006; and by SLP, 1/12, P = 0.0004). OCT and SLP revealed different aspects of RNFL changes associated with ONH swelling. OCT revealed thickening due to edema. SLP revealed a decrease in retardance in eyes with axonal injury associated with visual field loss, which is unlikely to recover.

  19. Scanning laser polarimetry, but not optical coherence tomography predicts permanent visual field loss in acute nonarteritic anterior ischemic optic neuropathy.

    Science.gov (United States)

    Kupersmith, Mark J; Anderson, Susan; Durbin, Mary; Kardon, Randy

    2013-08-15

    Scanning laser polarimetry (SLP) reveals abnormal retardance of birefringence in locations of the edematous peripapillary retinal nerve fiber layer (RNFL), which appear thickened by optical coherence tomography (OCT), in nonarteritic anterior ischemic optic neuropathy (NAION). We hypothesize initial sector SLP RNFL abnormalities will correlate with long-term regional visual field loss due to ischemic injury. We prospectively performed automated perimetry, SLP, and high definition OCT (HD-OCT) of the RNFL in 25 eyes with acute NAION. We grouped visual field threshold and RNFL values into Garway-Heath inferior/superior disc sectors and corresponding superior/inferior field regions. We compared sector SLP RNFL thickness with corresponding visual field values at presentation and at >3 months. At presentation, 12 eyes had superior sector SLP reduction, 11 of which had inferior field loss. Six eyes, all with superior field loss, had inferior sector SLP reduction. No eyes had reduced OCT-derived RNFL acutely. Eyes with abnormal field regions had corresponding SLP sectors thinner (P = 0.003) than for sectors with normal field regions. During the acute phase, the SLP-derived sector correlated with presentation (r = 0.59, P = 0.02) and with >3-month after presentation (r = 0.44, P = 0.02) corresponding superior and inferior field thresholds. Abnormal RNFL birefringence occurs in sectors corresponding to regional visual field loss during acute NAION when OCT-derived RNFL shows thickening. Since the visual field deficits show no significant recovery, SLP can be an early marker for axonal injury, which may be used to assess recovery potential at RNFL locations with respect to new treatments for acute NAION.

  20. Diagnostic capability of scanning laser polarimetry with and without enhanced corneal compensation and optical coherence tomography.

    Science.gov (United States)

    Benítez-del-Castillo, Javier; Martinez, Antonio; Regi, Teresa

    2011-01-01

    To compare the abilities of the current commercially available versions of scanning laser polarimetry (SLP) and optical coherence tomography (OCT), SLP-variable corneal compensation (VCC), SLP-enhanced corneal compensation (ECC), and high-definition (HD) OCT, in discriminating between healthy eyes and those with early-to-moderate glaucomatous visual field loss. Healthy volunteers and patients with glaucoma who met the eligibility criteria were consecutively enrolled in this prospective, cross-sectional, observational study. Subjects underwent complete eye examination, automated perimetry, SLP-ECC, SLP-VCC, and HD-OCT. Scanning laser polarimetry parameters were recalculated in 90-degree segments (quadrants) in the calculation circle to be compared. Areas under the receiver operating characteristic curve (AUROCs) were calculated for every parameter in order to compare the ability of each imaging modality to differentiate between normal and glaucomatous eyes. Fifty-five normal volunteers (mean age 59.1 years) and 33 patients with glaucoma (mean age 63.8 years) were enrolled. Average visual field mean deviation was -6.69 dB (95% confidence interval -8.07 to -5.31) in the glaucoma group. The largest AUROCs were associated with nerve fiber indicator (0.880 and 0.888) for the SLP-VCC and SLP-ECC, respectively, and with the average thickness in the HD-OCT (0.897). The best performing indices for the SLP-VCC, SLP-ECC, and HD OCT gave similar AUROCs, showing moderate diagnostic accuracy in patients with early to moderate glaucoma. Further studies are needed to evaluate the ability of these technologies to discriminate between normal and glaucomatous eyes.

  1. Characterization of Three Different Unusual S-Layer Proteins from Viridibacillus arvi JG-B58 That Exhibits Two Super-Imposed S-Layer Proteins

    OpenAIRE

    Suhr, Matthias; Lederer, Franziska L; Günther, Tobias J.; Raff, Johannes; Pollmann, Katrin

    2016-01-01

    Genomic analyses of Viridibacillus arvi JG-B58 that was previously isolated from heavy metal contaminated environment identified three different putative surface layer (S-layer) protein genes namely slp1, slp2, and slp3. All three genes are expressed during cultivation. At least two of the V. arvi JG-B58 S-layer proteins were visualized on the surface of living cells via atomic force microscopy (AFM). These S-layer proteins form a double layer with p4 symmetry. The S-layer proteins were isola...

  2. Nanoscale mono- and multi-layer cylinder structures formed by recombinant S-layer proteins of mosquitocidal Bacillus sphaericus C3-41.

    Science.gov (United States)

    Li, Jia; Yang, Lingling; Hu, Xiaomin; Zheng, Dasheng; Yan, Jianpin; Yuan, Zhiming

    2013-08-01

    The mature surface layer (S-layer) protein SlpC of mosquitocidal Bacillus sphaericus C3-41 comprises amino acids 31-1,176 and could recrystallize in vitro. The N-terminal SLH domain is responsible for binding function. Deletion of this part, S-layer proteins could not bind to the cell wall sacculi. To investigate the self-assembly ability of SlpC from B. sphaericus, nine truncations were constructed and their self-assembly properties were compared with the recombinant mature S-layer protein rSlpC₃₁₋₁,₁₇₆. The results showed that rSbsC₃₁₋₁,₁₇₆ and truncations rSlpC₂₁₁₋₁,₁₇₆, rSlpC₂₇₈₋₁,₁₇₆, rSlpC₃₁₋₁,₁₀₀, and rSlpC₃₁₋₁,₀₅₀ could assemble into multilayer cylinder structures, while N-terminal truncations rSlpC₃₃₈₋₁,₁₇₆, rSlpC₄₃₈₋₁,₁₇₆, and rSlpC₄₉₈₋₁,₁₇₆ mainly showed monolayer cylinders in recombinant Escherichia coli BL21 (DE3) cells. Growth phase analysis of the self-assembly process revealed that rSlpC₄₉₈₋₁,₁₇₆ mainly formed monolayer cylinders in the early stage (0.5 and 1 h induction of expression), but few double-layer or multilayer cylinders were also found with the cells growing, while rSlpC₃₁₋₁,₁₇₆ could formed multilayer cylinders in all the growth stage in the E. coli cells. It is concluded that the deletion of the C-terminal 126 aa or the N-terminal 497 aa did not interfere with the self-assembly process, the fragment (amino acids 278 to 337) is essential for the multilayer cylinder formation in E. coli BL21 (DE3) cells in the early stage and the fragment (amino acids 338 to 497) is related to monolayer cylinder formation. The information is important for further studies on the assembly mechanism of S-layer proteins and forms a basis for further studies concerning surface display and nanobiotechnology.

  3. Conductivity-depth Imaging Algorithm for Central-loop Helicopter TEM%中心回线式直升机 TEM 资料的电导率-深度成像方法

    Institute of Scientific and Technical Information of China (English)

    毛立峰

    2013-01-01

    field in the homogeneous half-space earth, and a data table about apparent conductivity and apparent depth is established to accelerate computing. Finally, the imaging depth is determined based on the depth change of the maximum electric field at the two adjacent delay time and then the CDI result is obtained consequently. The advantage of the method is that its high-efficiency of the table lookup technique can make the real-time CDI possible. Using a table lookup with a large conductivity range from 10-4 S/m to 102 S/m, tests on synthetic data demonstrate that the algorithm does a good job of solving conductive or resistive thin layers and 2D object.

  4. Adaptación de tres variedades de morera (Morus spp. en el estado de Hidalgo Adaptation of three mulberry (Morus spp. varieties in Hidalgo State

    Directory of Open Access Journals (Sweden)

    Alejandro Rodríguez-Ortega

    2012-07-01

    Full Text Available El objetivo del trabajo fue evaluar la adaptación de tres variedades de morera en las regiones del Valle del Mezquital, Huasteca y Otomí-Tepehua del estado de Hidalgo, establecidas a principios de octubre de 2010 para el fomento de la sericultura. Se empleó un diseño completamente al azar con arreglo factorial 3 (región x 3 (variedad. Se registró información de 35 plantas por variedad por 6 meses de estudio. Las variables analizadas fueron: porcentaje de supervivencia, vigor de la planta, incidencia de plagas y enfermedades, altura, número de yemas, número de ramas, número de hojas por planta y área foliar. Se realizó ANOVA y comparación de medias, encontrando porcentajes de super vivencia mayores a 95% en lastres regiones de estudio (p> 0.05. La variedad SLP5 en la región Otomí-Tepehua (p> 0.05, presentó el menor porcentaje de supervivencia (89%. El vigor de planta fue inferior en el Valle del Mezquital y en la variedad SLP5. La altura final de plantas fue diferente entre regiones; Otomí-Tepehua (67.7 cm, Huasteca (63 cm y Valle del Mezquital (44.7 cm. Las variedades SLP3 y SLP5 presentaron mayor altura (p> 0.05. En la región del Valle del Mezquital y en la variedad SLP5 se registró mayor emisión de yemas. La variedad SLP3 y Kamva registraron mayor número de ramas, hojas y área foliar en las regiones Huasteca y Otomí-Tepehua, mientras que la variedad SLP5presentó hojas pequeñas y fue susceptible a enfermedades. Se concluye que es factible el establecimiento de la variedad SLP3 y Kamva por su alta adaptabilidad a las tres regiones del estado de Hidalgo.The objective of this paper was to evaluate the adaptation of three varieties of mulberry in the regions of Valle del Mezquital, Huasteca and Otomí-Tepehua, Hidalgo State, established in early October, 2010, for the promotion of sericulture. We used a completely randomized design with factorial arrangement 3 (region x 3 (variety. The information was recorded from 35

  5. Event-based progression detection strategies using scanning laser polarimetry images of the human retina

    NARCIS (Netherlands)

    Vermeer, K.A.; Lo, B.; Zhou, Q.; Vos, F.M.; Vossepoel, A.M.; Lemij, H.G.

    2011-01-01

    Monitoring glaucoma patients and ensuring optimal treatment requires accurate and precise detection of progression. Many glaucomatous progression detection strategies may be formulated for Scanning Laser Polarimetry (SLP) data of the local nerve fiber thickness. In this paper, several strategies, al

  6. 75 FR 54686 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2010-09-08

    ... Effectiveness of Proposed Rule Change Extending the Operation of NYSE's Supplemental Liquidity Providers Pilot... the operation of its Supplemental Liquidity Providers Pilot (``SLP Pilot'' or ``Pilot'') (see Rule... The Exchange proposes to extend the operation of its Supplemental Liquidity Providers...

  7. Event-based progression detection strategies using scanning laser polarimetry images of the human retina

    NARCIS (Netherlands)

    Vermeer, K.A.; Lo, B.; Zhou, Q.; Vos, F.M.; Vossepoel, A.M.; Lemij, H.G.

    2011-01-01

    Monitoring glaucoma patients and ensuring optimal treatment requires accurate and precise detection of progression. Many glaucomatous progression detection strategies may be formulated for Scanning Laser Polarimetry (SLP) data of the local nerve fiber thickness. In this paper, several strategies, al

  8. Scanning laser polarimetry in glaucoma.

    Science.gov (United States)

    Dada, Tanuj; Sharma, Reetika; Angmo, Dewang; Sinha, Gautam; Bhartiya, Shibal; Mishra, Sanjay K; Panda, Anita; Sihota, Ramanjit

    2014-11-01

    Glaucoma is an acquired progressive optic neuropathy which is characterized by changes in the optic nerve head and retinal nerve fiber layer (RNFL). White-on-white perimetry is the gold standard for the diagnosis of glaucoma. However, it can detect defects in the visual field only after the loss of as many as 40% of the ganglion cells. Hence, the measurement of RNFL thickness has come up. Optical coherence tomography and scanning laser polarimetry (SLP) are the techniques that utilize the evaluation of RNFL for the evaluation of glaucoma. SLP provides RNFL thickness measurements based upon the birefringence of the retinal ganglion cell axons. We have reviewed the published literature on the use of SLP in glaucoma. This review elucidates the technological principles, recent developments and the role of SLP in the diagnosis and monitoring of glaucomatous optic neuropathy, in the light of scientific evidence so far.

  9. Scanning laser polarimetry in glaucoma

    Directory of Open Access Journals (Sweden)

    Tanuj Dada

    2014-01-01

    Full Text Available Glaucoma is an acquired progressive optic neuropathy which is characterized by changes in the optic nerve head and retinal nerve fiber layer (RNFL. White-on-white perimetry is the gold standard for the diagnosis of glaucoma. However, it can detect defects in the visual field only after the loss of as many as 40% of the ganglion cells. Hence, the measurement of RNFL thickness has come up. Optical coherence tomography and scanning laser polarimetry (SLP are the techniques that utilize the evaluation of RNFL for the evaluation of glaucoma. SLP provides RNFL thickness measurements based upon the birefringence of the retinal ganglion cell axons. We have reviewed the published literature on the use of SLP in glaucoma. This review elucidates the technological principles, recent developments and the role of SLP in the diagnosis and monitoring of glaucomatous optic neuropathy, in the light of scientific evidence so far.

  10. Identification and characterization of the surface-layer protein of Clostridium tetani.

    Science.gov (United States)

    Qazi, Omar; Brailsford, Alan; Wright, Anne; Faraar, Jeremy; Campbell, Jim; Fairweather, Neil

    2007-09-01

    Many bacterial species produce a paracrystalline layer, the surface layer, which completely surrounds the exterior of the cell. In some bacteria, the surface layer is implicated in pathogenesis. Two proteins present in cell wall extracts from Clostridium tetani have been investigated and identified one of these has been unambiguously as the surface-layer protein (SLP). The gene, slpA, has been located in the genome of C. tetani E88 that encodes the SLP. The molecular mass of the protein as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis is considerably larger than that predicted from the gene; however the protein does not appear to be glycosylated. Furthermore, analysis of five C. tetani strains, including three recent clinical isolates, shows considerable variation in the sizes of the SLP.

  11. A novel non-mineral oil-based adjuvant. II. Efficacy of a synthetic sulfolipopolysaccharide in a squalane-in-water emulsion in pigs.

    Science.gov (United States)

    Hilgers, L A; Platenburg, P L; Luitjens, A; Groenveld, B; Dazelle, T; Weststrate, M W

    1994-05-01

    The adjuvanticity of a sulfolipopolysaccharide (SLP) incorporated into a squalane-in-water emulsion (SLP/S/W) was compared with that of a mineral oil-in-water (O/W) adjuvant currently used in commercial porcine vaccines. Groups of pigs were immunized twice with vaccines comprising either inactivated influenza virus (iFlu3 containing strains A/Swine, MRC-11 and X-79), inactivated pseudorabies virus (iPRV), live pseudorabies virus (PRV) or inactivated porcine parvovirus (iPPV) as antigen and SLP/S/W or O/W as adjuvant. Antibody titres in serum 2 or 3 weeks after the second immunization were measured by haemagglutination inhibition (HI) or serum neutralization (SN) assays. Both adjuvants significantly augmented the antibody responses against the antigens tested. Mean factors of increase obtained by SLP/S/W and O/W were: 315 and 91, respectively, for A/Swine; 478 and 137 for MRC-11; 362 and 128 for X-79; 69 and 49 for iPRV; and 23 and 7 for live PRV. Increased humoral immunity against live PRV was affirmed by reduced levels and duration of virus excreted by pigs after challenge with virulent PRV. Immunization of pigs with iPPV plus adjuvant SLP/S/W gave 36-fold higher titres than with O/W. It was concluded that SLP/S/W is more effective than O/W in stimulating humoral immunity against the viral antigens examined and that the two constituents SLP and S/W interact synergistically. Advantages of SLP/S/W over O/W include stronger adjuvanticity, better biocompatibility and lower doses of active substances.

  12. University of Akron: Training Speech-Language Pathology Specialists to Provide Quality Service to Children Who Are Deaf or Hard of Hearing--A Collaborative Preservice Program

    Science.gov (United States)

    Wray, Denise; Flexer, Carol

    2010-01-01

    A collaborative team of faculty from The University of Akron (UA) in Akron, Ohio, and Kent State University (KSU) in Kent, Ohio, were awarded a federal grant from the U.S. Department of Education to develop a specialty area in the graduate speech-language pathology (SLP) programs of UA and KSU that would train a total of 32 SLP students (trainees)…

  13. Analysis of the Origin of Atypical Scanning Laser Polarimetry Patterns by Polarization-Sensitive Optical Coherence Tomography

    Science.gov (United States)

    Götzinger, Erich; Pircher, Michael; Baumann, Bernhard; Hirn, Cornelia; Vass, Clemens; Hitzenberger, Christoph K.

    2010-01-01

    Purpose To analyze the physical origin of atypical scanning laser polarimetry (SLP) patterns. To compare polarization-sensitive optical coherence tomography (PS-OCT) scans to SLP images. To present a method to obtain pseudo-SLP images by PS-OCT that are free of atypical artifacts. Methods Forty-one eyes of healthy subjects, subjects with suspected glaucoma, and patients with glaucoma were imaged by SLP (GDx VCC) and a prototype spectral domain PS-OCT system. The PS-OCT system acquires three-dimensional (3D) datasets of intensity, retardation, and optic axis orientation simultaneously within 3 seconds. B-scans of intensity and retardation and en face maps of retinal nerve fiber layer (RNFL) retardation were derived from the 3D PS-OCT datasets. Results were compared with those obtained by SLP. Results Twenty-two eyes showed atypical retardation patterns, and 19 eyes showed normal patterns. From the 22 atypical eyes, 15 showed atypical patterns in both imaging modalities, five were atypical only in SLP images, and two were atypical only in PS-OCT images. In most (15 of 22) atypical cases, an increased penetration of the probing beam into the birefringent sclera was identified as the source of atypical patterns. In such cases, the artifacts could be eliminated in PS-OCT images by depth segmentation and exclusion of scleral signals. Conclusions PS-OCT provides deeper insight into the contribution of different fundus layers to SLP images. Increased light penetration into the sclera can distort SLP retardation patterns of the RNFL. PMID:19036999

  14. Two Novel 30K Proteins Overexpressed in Baculovirus System and Their Antiapoptotic Effect in Insect and Mammalian Cells

    Directory of Open Access Journals (Sweden)

    Wei Yu

    2013-01-01

    Full Text Available The 30K family of proteins is important in energy metabolism and may play a role in inhibiting cellular apoptosis in silkworms (Bombyx mori. Several 30K-family proteins have been identified. In this study, two new silkworm genes, referred to as Slp (NM 001126256 and Lsp-t (NM 001043443, were analyzed by a bioinformatics approach according to the sequences of 30K proteins previously reported in the silkworm. Both Slp and Lsp-t shared more than 41% amino acid sequence homology with the reported 30K proteins and displayed a conserved domain consistent with that of lipoprotein-11. Additionally, the cDNA sequences of both Slp and Lsp-t were obtained from the fat bodies of silkworm larvae by reverse transcription polymerase chain reaction. Both genes were expressed in BmN cells using the Bac-to-Bac system. Purified Slp and Lsp-t were added to cultured BmN and human umbilical vein endothelial cells (HUVEC that were treated with H2O2. Both Slp and Lsp-t significantly enhanced the viability and suppressed DNA fragmentation in H2O2 treated BmN and HUVEC cells. This study suggested that Slp and Lsp-t exhibit similar biological activities as their known 30K-protein counterparts and mediate an inhibitory effect against H2O2-induced apoptosis.

  15. Ferromagnetic glass-coated microwires with good heating properties for magnetic hyperthermia

    Science.gov (United States)

    Talaat, A.; Alonso, J.; Zhukova, V.; Garaio, E.; García, J. A.; Srikanth, H.; Phan, M. H.; Zhukov, A.

    2016-12-01

    The heating properties of Fe71.7Si11B13.4Nb3Ni0.9 amorphous glass-coated microwires are explored for prospective applications in magnetic hyperthermia. We show that a single 5 mm long wire is able to produce a sufficient amount of heat, with the specific loss power (SLP) reaching a value as high as 521 W/g for an AC field of 700 Oe and a frequency of 310 kHz. The large SLP is attributed to the rectangular hysteresis loop resulting from a peculiar domain structure of the microwire. For an array of parallel microwires, we have observed an SLP improvement by one order of magnitude; 950 W/g for an AC field of 700 Oe. The magnetostatic interaction strength essential in the array of wires can be manipulated by varying the distance between the wires, showing a decreasing trend in SLP with increasing wire separation. The largest SLP is obtained when the wires are aligned along the direction of the AC field. The origin of the large SLP and relevant heating mechanisms are discussed.

  16. The β-barrel assembly machinery (BAM) is required for the assembly of a primitive S-layer protein in the ancient outer membrane of Thermus thermophilus.

    Science.gov (United States)

    Acosta, Federico; Ferreras, Eloy; Berenguer, José

    2012-11-01

    The ancient bacterial lineage Thermus spp has a primitive form of outer membrane attached to the cell wall through SlpA, a protein that shows intermediate properties between S-layer proteins and outer membrane (OM) porins. In E. coli and related Proteobacteria, porins are secreted through the BAM (β-barrel assembly machinery) pathway, whose main component is BamA. A homologue to this protein is encoded in all the Thermus spp so far sequenced, so we wondered if this pathway could be responsible for SlpA secretion in this ancient bacterial model. To analyse this hypothesis, we attempted to get mutants on this BamA(th) of T. thermophilus HB27. Knockout and deletion mutants lacking the last 10 amino acids were not viable, whereas its depletion by means of a BamA antisense RNA lead defective attachment to the cell wall of its OM-like envelope. Such defects were related to defective folding of the SlpA protein that was more sensitive to proteases than in a wild-type strain. A similar phenotype was found in mutants lacking the terminal Phe of SlpA. Further protein-protein interaction assays confirmed the existence of specific binding between SlpA and BamA(th). Taking together, these data suggest that SlpA is secreted through a BAM-like pathway in this ancestral bacterial lineage, supporting an ancient origin of this pathway before the evolution of the Proteobacteria.

  17. "It's not everyday that parents get a chance to talk like this": Exploring parents' perceptions and expectations of speech-language pathology services for children with intellectual disability.

    Science.gov (United States)

    Carroll, Clare

    2010-08-01

    Tailoring the delivery of disability services to the preferences and requirements of service users allows for more effective partnerships. The aim of this research was to explore parents' perceptions and the expectations of their child's speech-language pathology (SLP) within an intellectual disability service. Parents of school-aged children with intellectual disability who received a SLP service in Ireland participated in the research: 17 parents participated in focus groups and 103 parents answered questionnaires. The core themes from the focus groups, which subsequently informed the questionnaire design, were: experience of the SLP service, communication difficulties, expectations of the SLP service, and future developments. The key questionnaire results indicated that parents viewed their SLP as the "expert" and viewed school-based and clinic-based services differently. Parents were more likely to believe that their child would always need therapy if they received a school-based service. Whereas, parents were more likely to think that their child's speech was improving as they got older and were more likely to be aware of therapy activities if therapy was clinic-based. The findings have implications for the delivery of SLP services suggesting that clarification of parents' roles and expectations are required.

  18. The personality of past, present and future speech-language pathology students.

    Science.gov (United States)

    Byrne, Nicole

    2017-08-24

    As allied health professions change over time to keep up with and reflect a rapidly changing society, it is quite possible that the people attracted to the profession may also change. If this is the case, then knowing this could be critical for future workforce marketing, training and planning. The aim was to investigate whether the personality of students entering a speech-language pathology (SLP) program had changed over time and whether there were generational differences in personality. The study used the Big Five personality inventory to consider whether there were differences in the personality in speech-language pathology (SLP) students enrolled in the same regional university in Australia in 2005 and 2016. The results showed there were significant differences between the two groups on the Agreeableness and Extroversion scales. The students who were more Conscientious were also more Confident in their ability to perform as an SLP. Generational differences across the two cohorts were also considered. SLP is a dynamic profession that is reflected through an evolving scope of practice, increasing utilization of technology and specialization. As careers evolve it is logical that the people attracted to those careers may also shift; as demonstrated here via changes in the personality of SLP students. Understanding the personality of current SLP students and future Generation Z students may assist universities to identify specific skills and experiences students need to be successful in the workforce. © 2017 Royal College of Speech and Language Therapists.

  19. Rat enterocytes secrete SLPs containing alkaline phosphatase and cubilin in response to corn oil feeding.

    Science.gov (United States)

    Mahmood, Akhtar; Shao, Jian-su; Alpers, David H

    2003-08-01

    Surfactant-like particles (SLP) are unilamellar secreted membranes associated with the process of lipid absorption and isolated previously only from the apical surface of enterocytes. In this paper, the intracellular membrane has been isolated from corn oil-fed animals, identified by its content of the marker protein intestinal alkaline phosphatase (IAP). Another brush-border protein, cubilin, and its anchoring protein megalin have been identified as components of extracellular SLP, but only cubilin is present to any extent in intracellular SLP. During fat absorption, IAP is modestly enriched in intracellular SLP, but full-length cubilin (migrating at 210 kDa in fat-fed mucosal fractions) falls by one-half, although fragments of cubilin are abundant in the intracellular SLP. Both IAP and cubilin colocalize to the same cells during corn oil absorption and colocalize around lipid droplets. This localization is more intense during feeding of corn oil with Pluronic L-81, a detergent that allows uptake of fatty acids and monoglycerides from the lumen, but blocks chylomicron secretion. Confocal microscopy confirms the colocalization of IAP and the ligand for cubilin, intrinsic factor. Possible roles for cubilin in intracellular SLP include facilitating movement of the lipid droplet through the cell and binding to the basolateral membrane before reverse endocytosis.

  20. Retinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry.

    Science.gov (United States)

    Stemplewitz, Birthe; Kromer, Robert; Vettorazzi, Eik; Hidding, Ute; Frings, Andreas; Buhmann, Carsten

    2017-07-13

    This cross-sectional study compared the retinal morphology between patients with progressive supranuclear palsy (PSP) and healthy controls. (The retinal nerve fiber layer (RNFL) around the optic disc and the retina in the macular area of 22 PSP patients and 151 controls were investigated by spectral domain optical coherence tomography (SD-OCT). Additionally, the RNFL and the nerve fiber index (NFI) were measured by scanning laser polarimetry (SLP). Results of RNFL measurements with SD-OCT and SLP were compared to assess diagnostic discriminatory power. Applying OCT, PSP patients showed a smaller RNFL thickness in the inferior nasal and inferior temporal areas. The macular volume and the thickness of the majority of macular sectors were reduced compared to controls. SLP data showed a thinner RNFL thickness and an increase in the NFI in PSP patients. Sensitivity and specificity to discriminate PSP patients from controls were higher applying SLP than SD-OCT. Retinal changes did not correlate with disease duration or severity in any OCT or SLP measurement. PSP seems to be associated with reduced thickness and volume of the macula and reduction of the RNFL, independent of disease duration or severity. Retinal imaging with SD-OCT and SLP might become an additional tool in PSP diagnosis.

  1. Empty nano and micro-structured lipid carriers of virgin coconut oil for skin moisturisation.

    Science.gov (United States)

    Noor, Norhayati Mohamed; Khan, Abid Ali; Hasham, Rosnani; Talib, Ayesha; Sarmidi, Mohamad Roji; Aziz, Ramlan; Aziz, Azila Abd

    2016-08-01

    Virgin coconut oil (VCO) is the finest grade of coconut oil, rich in phenolic content, antioxidant activity and contains medium chain triglycerides (MCTs). In this work formulation, characterisation and penetration of VCO-solid lipid particles (VCO-SLP) have been studied. VCO-SLP were prepared using ultrasonication of molten stearic acid and VCO in an aqueous solution. The electron microscopy imaging revealed that VCO-SLP were solid and spherical in shape. Ultrasonication was performed at several power intensities which resulted in particle sizes of VCO-SLP ranged from 0.608 ± 0.002 µm to 44.265 ± 1.870 µm. The particle size was directly proportional to the applied power intensity of ultrasonication. The zeta potential values of the particles were from -43.2 ± 0.28 mV to -47.5 ± 0.42 mV showing good stability. The cumulative permeation for the smallest sized VCO-SLP (0.608 µm) was 3.83 ± 0.01 µg/cm(2) whereas for larger carriers it was reduced (3.59 ± 0.02 µg/cm(2)). It is concluded that SLP have the potential to be exploited as a micro/nano scale cosmeceutical carrying vehicle for improved dermal delivery of VCO.

  2. Reflection and transmission of plane SH-waves in an initially stressed inhomogeneous anisotropic magnetoelastic medium

    Science.gov (United States)

    Majhi, S.; Pal, P. C.; Kumar, S.

    2017-01-01

    This study investigates the reflection and transmission of plane SH-waves in two semi-infinite anisotropic magnetoelastic media. The lower half-space is considered as initially stressed and inhomogeneous. The density of lower half-space is taken exponentially varying with depth. The solutions for half-spaces are obtained analytically. The expressions for reflection and transmission coefficient are obtained in the closed form subject to continuity conditions at the interfaces of anisotropic magnetoelastic half-spaces and the Snell's law. It is found that these coefficients depend on the initial stress, inhomogeneity parameter, the magnetoelastic coupling parameter, and the angle at which wave crosses the magnetic field of the half-spaces. Numerical computations are performed for these coefficients for a specific model of two different anisotropic magnetoelastic half-spaces. The numerical results are illustrated by the graph of reflection and transmission coefficient versus the angle of incidence. In general, as the initial stress increases the reflection and transmission coefficient increases, the affect is more prominent for more than 10 GPa. Inhomogeneity in the density of the material also increases the reflection and transmission coefficient. The anisotropic magnetoelastic parameter and the angle at which the wave crosses the magnetic field for both the half-spaces have a quite significant effect on the reflection and transmission coefficient.

  3. Reflection and transmission of plane SH-waves in an initially stressed inhomogeneous anisotropic magnetoelastic medium

    Science.gov (United States)

    Majhi, S.; Pal, P. C.; Kumar, S.

    2016-06-01

    This study investigates the reflection and transmission of plane SH-waves in two semi-infinite anisotropic magnetoelastic media. The lower half-space is considered as initially stressed and inhomogeneous. The density of lower half-space is taken exponentially varying with depth. The solutions for half-spaces are obtained analytically. The expressions for reflection and transmission coefficient are obtained in the closed form subject to continuity conditions at the interfaces of anisotropic magnetoelastic half-spaces and the Snell's law. It is found that these coefficients depend on the initial stress, inhomogeneity parameter, the magnetoelastic coupling parameter, and the angle at which wave crosses the magnetic field of the half-spaces. Numerical computations are performed for these coefficients for a specific model of two different anisotropic magnetoelastic half-spaces. The numerical results are illustrated by the graph of reflection and transmission coefficient versus the angle of incidence. In general, as the initial stress increases the reflection and transmission coefficient increases, the affect is more prominent for more than 10 GPa. Inhomogeneity in the density of the material also increases the reflection and transmission coefficient. The anisotropic magnetoelastic parameter and the angle at which the wave crosses the magnetic field for both the half-spaces have a quite significant effect on the reflection and transmission coefficient.

  4. Reconstructing Winter North Pacific Sea-Level Pressure Anomalies Over the Past Three Centuries Using a New Calibration Method with the Eclipse and Mt. Logan Ice Cores

    Science.gov (United States)

    Kelsey, E. P.; Wake, C. P.; Osterberg, E. C.

    2012-12-01

    A deeper understanding of the behavior of North Pacific extratropical cyclones and anticyclones prior to the instrumental era is needed to advance our understanding of North Pacific climate variability. To help achieve this objective, we develop and use a new nonlinear ice core calibration procedure with the Eclipse (3017 m a.s.l.) and Mt. Logan (5400 m a.s.l.) ice core records from Yukon, Canada to isolate the ranges of ice core values that are consistently associated with North Pacific wintertime sea-level pressure (SLP) anomalies. Over the calibration period (1872-2001), each ice core record is ranked and divided into 10 groups of 13 years. Then for each group, the frequency of positive and negative SLP anomalies at each grid point is contoured and the composite mean SLP anomaly values are shaded. These plots elucidate areas where statistically significant SLP anomalies occur frequently in association with groups of ice core values. This new calibration procedure shows that the lowest and the two highest groups of Mt. Logan annual [Na+] are sensitive to SLP anomalies in the central and eastern Pacific and the second lowest [Na+] group is sensitive to western Pacific SLP anomalies. The highest and lowest Eclipse cold-season accumulation groups are most sensitive to SLP anomalies more distant in the western and central Pacific. This result is surprising in light of stable isotope studies suggesting a more distant moisture source for Mt. Logan. A reconstruction using these calibrated records indicates the Aleutian Low was predominantly weaker than average between 1699-1871. Our results highlight that having these geographically close ice core records is important to developing a deeper understanding of North Pacific climate variability.

  5. A novel non-mineral oil-based adjuvant. I. Efficacy of a synthetic sulfolipopolysaccharide in a squalane-in-water emulsion in laboratory animals.

    Science.gov (United States)

    Hilgers, L A; Platenburg, P L; Luitjens, A; Groenveld, B; Dazelle, T; Ferrari-Laloux, M; Weststrate, M W

    1994-05-01

    Sulfolipopolysaccharides (SLPs) were synthesized by reaction of the synthetic polysucrose polymer Ficoll-400 with chlorosulfonic acid and lauroyl chloride in anhydrous medium. Hydrophobic derivatives were obtained by addition of a small number of sulfate and a large number of lipid groups. Gel-permeation high-performance liquid chromatography (g.p.-h.p.l.c.) exhibited a wide range in molecular weight of both Ficoll-400 and SLP polymers. The calculated weight-average molecular weight (Mw) of Ficoll-400 and SLP using polystyrene polymers as references was 187,000 and 380,000 respectively, exhibiting a twofold increase in molecular weight upon derivatization. Adjuvanticity of hydrophobic SLPs with 0.2 sulfate and 1.5 lipid groups per sucrose monomer, a squalane-in-water emulsion (S/W), SLP incorporated into S/W (SLP/S/W), and a mineral oil-based emulsion (O/W) was investigated in combination with different antigens in mice and guinea-pigs. Antibody responses in serum against ovalbumin (OVA), dinitrophenylated bovine serum albumin (DNP-BSA), inactivated influenza virus strain MRC-11 (MRC-11), a mixture of three influenza virus strains (iFlu3) and inactivated pseudorabies virus (iPRV) were measured by either haemagglutination (HA), haemagglutination inhibition (HI) or serum neutralization (SN). Vaccines were prepared by simply mixing one volume of antigen with one volume of adjuvant solution. Antibody titres after one or two injections with these antigens were enhanced significantly by SLP/S/W, SLP, S/W and O/W and in most studies, SLP/S/W was demonstrated to be more effective than either the two constituent components or the O/W adjuvant.(ABSTRACT TRUNCATED AT 250 WORDS)

  6. A cost-effectiveness analysis of using TheraBite in a preventive exercise program for patients with advanced head and neck cancer treated with concomitant chemo-radiotherapy.

    Science.gov (United States)

    Retèl, Valesca P; van der Molen, Lisette; Steuten, Lotte M G; van den Brekel, Michiel W; Hilgers, Frans J M

    2016-03-01

    Previous studies have shown that a "Preventive Exercise Program" (PREP) is cost-effective compared to the standard exercise program provided in "Usual Care" (UC) in patients with advanced head and neck cancer. The current paper specifically estimates the cost-effectiveness of the TheraBite jaw rehabilitation device (TB) which is used as part of the PREP, compared to Speech Language Pathology (SLP) sessions as part of UC, and herewith intents to inform reimbursement discussions regarding the TheraBite device. Costs and outcomes [quality-adjusted life-years (QALYs)] of the TB compared to SLP were estimated using a Markov model of advanced head and neck cancer patients. Secondary outcome variables were trismus, feeding substitutes, facial pain, and pneumonia. The incremental cost-effectiveness ratio (ICER) was estimated from a health care perspective of the Netherlands, with a time horizon of 2 years. The total health care costs per patient were estimated to amount to €5,129 for the TB strategy and €6,915 for the SLP strategy. Based on the current data, the TB strategy yielded more quality-adjusted life-years (1.28) compared to the SLP strategy (1.24). Thus, the TB strategy seems more effective (+0.04) and less costly (-€1,786) than the SLP only strategy. At the prevailing threshold of €20,000/QALY the probability for the TB strategy being cost-effective compared to SLP was 70 %. To conclude, analysis of presently available data indicates that TB is expected to be cost-effective compared to SLP in a preventive exercise program for concomitant chemo-radiotherapy for advanced head and neck cancer patients.

  7. Methylene blue stimulates substrate-level phosphorylation catalysed by succinyl-CoA ligase in the citric acid cycle.

    Science.gov (United States)

    Komlódi, T; Tretter, L

    2017-09-01

    Methylene blue (MB), a potential neuroprotective agent, is efficient in various neurodegenerative disease models. Beneficial effects of MB have been attributed to improvements in mitochondrial functions. Substrate-level phosphorylation (SLP) results in the production of ATP independent from the ATP synthase (ATP-ase). In energetically compromised mitochondria, ATP produced by SLP can prevent the reversal of the adenine nucleotide translocase and thus the hydrolysis of glycolytic ATP. The aim of the present study was to investigate the effect of MB on mitochondrial SLP catalysed by succinyl-CoA ligase. Measurements were carried out on isolated guinea pig cortical mitochondria respiring on α-ketoglutarate, glutamate, malate or succinate. The mitochondrial functions and parameters like ATP synthesis, oxygen consumption, membrane potential, and NAD(P)H level were followed online, in parallel with the redox state of MB. SLP-mediated ATP synthesis was measured in the presence of inhibitors for ATP-ase and adenylate kinase. In the presence of the ATP-ase inhibitor oligomycin MB stimulated respiration with all of the respiratory substrates. However, the rate of ATP synthesis increased only with substrates α-ketoglutarate and glutamate (forming succinyl-CoA). MB efficiently stimulated SLP and restored the membrane potential in mitochondria also with the combined inhibition of Complex I and ATP synthase. ATP formed by SLP alleviated the energetic insufficiency generated by the lack of oxidative phosphorylation. Thus, the MB-mediated stimulation of SLP might be important in maintaining the energetic competence of mitochondria and in preventing the mitochondrial hydrolysis of glycolytic ATP. The mitochondrial effects of MB are explained by the ability to accept electrons from reducing equivalents and transfer them to cytochrome c bypassing the respiratory Complexes I and III. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Reflection of plane waves from free surface of a microstretch elastic solid

    Indian Academy of Sciences (India)

    Baljeet Singh

    2002-03-01

    In the present investigation, it is shown that there exists five basic waves in a microstretch elastic solid half-space. The problem of reflection of plane waves from free surface of a microstretch elastic solid half-space is studied. The energy ratios for various reflected waves are obtained for aluminium- epoxy composite as a microstretch elastic solid half-space. The variations of the energy ratios with the angle of incidence are shown graphically. The microstretch effect is shown on various reflected waves.

  9. Plane waves in a thermally conducting viscous liquid

    Indian Academy of Sciences (India)

    Baljeet Singh

    2004-02-01

    The aim of this paper is to investigate plane waves in a thermally conducting viscous liquid half-space with thermal relaxation times. There exist three basic waves, namely; thermal wave, longitudinal wave and transverse wave in a thermally conducting viscous liquid half-space. Reflection of plane waves from the free surface of a thermally conducting viscous liquid half-space is studied. The results are obtained in terms of amplitude ratios and are compared with those without viscosity and thermal disturbances.

  10. Deterministic and Stochastic Wavefields in the Near-Field from Explosive Sources

    Science.gov (United States)

    1989-05-24

    characterization procedures were developed to support the source study . The techniques and format developed in this study could be applied to other geological...Potentials ........ 72 3.5 Half-space Synthetics: HS115 Path, Basic Source ..... .. 77 vii i 3.i Half-space Synthetics at 9 Meters: Source Study ...... 79...3.7 Half-space Synthetics at 27 Meters: Source Study .... 82 3.8 Layered Half-sp;•ce Synthetics: Path 14, Basic Source . 86 3.9 Layered Half

  11. Analytical solution of second Stokes problem about behaviour of gas over fluctuating surface by means of ellipsoidal statistical equation

    CERN Document Server

    Latyshev, A V

    2012-01-01

    Second Stokes problem about behaviour of rarefied gas filling half-space is analytically solved. A plane limiting half-space makes harmonious fluctuations in the plane. The kinetic equation with modelling integral collisions in form of ellipsoidal statistical model is used . The case of diffusion reflexions of gas molecules from a wall is considered. Function distribution of gas molecules is constructed and mass velocity of gas also in half-space is found. Hydrodynamic character of the solution at small frequencies of fluctuation plane limiting gas is revealed. The force of a friction operating from gas on border making in the plane oscillatory movement is found.

  12. Genetic structure of the populations migrating from San Luis Potosi and Zacatecas to Nuevo León in Mexico.

    Science.gov (United States)

    Cerda-Flores, R M; Kshatriya, G K; Barton, S A; Leal-Garza, C H; Garza-Chapa, R; Schull, W J; Chakraborty, R

    1991-06-01

    The Mexicans residing in the Monterrey metropolitan area in Nuevo León, Mexico, were grouped by generation and birthplace [Monterrey Metropolitan Area (MMA), San Luis Potosi (SLP), and Zacatecas (ZAC)] of the four grandparents to determine the extent of genetic variation within this population and the genetic differences, if any, between the natives living in the MMA and the immigrant populations from SLP and ZAC. Nine genetic marker systems were analyzed. The genetic distance analysis indicates that SLP and ZAC are similar to the MMA, irrespective of birthplace and generation. Gene diversity analysis (GST) suggests that more than 96% of the total gene diversity (HT) can be attributed to individual variation within the population. The genetic admixture analysis suggests that the Mexicans of the MMA, SLP, and ZAC, stratified by birthplace and generation, have received a predominantly Spanish contribution (78.5%), followed by a Mexican Indian contribution (21.5%). Similarly, admixture analysis, conducted on the population of Nuevo León and stratified by generation, indicates a substantial contribution from the MMA (64.6%), followed by ZAC (22.1%) and SLP (13.3%). Finally, we demonstrate that there is no nonrandom association of alleles among the genetic marker systems (i.e., no evidence of gametic disequilibrium) despite the Mestizo origin of this population.

  13. Adopting public health approaches to communication disability: challenges for the education of speech-language pathologists.

    Science.gov (United States)

    Wylie, Karen; McAllister, Lindy; Davidson, Bronwyn; Marshall, Julie; Law, James

    2014-01-01

    Public health approaches to communication disability challenge the profession of speech-language pathology (SLP) to reconsider both frames of reference for practice and models of education. This paper reviews the impetus for public health approaches to communication disability and considers how public health is, and could be, incorporated into SLP education, both now and in the future. The paper describes tensions between clinical services, which have become increasingly specialized, and public health approaches that offer a broader view of communication disability and communication disability prevention. It presents a discussion of these tensions and asserts that public health approaches to communication are themselves a specialist field, requiring specific knowledge and skills. The authors suggest the use of the term 'communication disability public health' to refer to this type of work and offer a preliminary definition in order to advance discussion. Examples from three countries are provided of how some SLP degree programmes are integrating public health into the SLP curriculum. Alternative models of training for communication disability public health that may be relevant in the future in different contexts and countries are presented, prompting the SLP profession to consider whether communication disability public health is a field of practice for speech-language pathologists or whether it has broader workforce implications. The paper concludes with some suggestions for the future which may advance thinking, research and practice in communication disability public health. © 2015 S. Karger AG, Basel.

  14. Structures, properties, and energy-storage mechanisms of the semi-lunar process cuticles in locusts.

    Science.gov (United States)

    Wan, Chao; Hao, Zhixiu; Feng, Xiqiao

    2016-10-17

    Locusts have excellent jumping and kicking abilities to survive in nature, which are achieved through the energy storage and release processes occurring in cuticles, especially in the semi-lunar processes (SLP) at the femorotibial joints. As yet, however, the strain energy-storage mechanisms of the SLP cuticles remain unclear. To decode this mystery, we investigated the microstructure, material composition, and mechanical properties of the SLP cuticle and its remarkable strain energy-storage mechanisms for jumping and kicking. It is found that the SLP cuticle of adult Locusta migratoria manilensis consists of five main parts that exhibit different microstructural features, material compositions, mechanical properties, and biological functions in storing strain energy. The mechanical properties of these five components are all transversely isotropic and strongly depend on their water contents. Finite element simulations indicate that the two parts of the core region of the SLP cuticle likely make significant contributions to its outstanding strain energy-storage ability. This work deepens our understanding of the locomotion behaviors and superior energy-storage mechanisms of insects such as locusts and is helpful for the design and fabrication of strain energy-storage devices.

  15. Accelerated Life Testing and Service Lifetime Prediction for PV Technologies in the Twenty-First Century

    Energy Technology Data Exchange (ETDEWEB)

    Czanderna, A. W.; Jorgensen, G. J.

    1999-07-13

    The purposes of this paper are to (1) discuss the necessity for conducting accelerated life testing (ALT) in the early stages of developing new photovoltaic (PV) technologies, (2) elucidate the crucial importance for combining ALT with real-time testing (RTT) in terrestrial environments for promising PV technologies for the 21st century, and (3) outline the essential steps for making a service lifetime prediction (SLP) for any PV technology. The specific objectives are to (a) illustrate the essential need for ALT of complete, encapsulated multilayer PV devices, (b) indicate the typical causes of degradation in PV stacks, (c) elucidate the complexity associated with quantifying the durability of the devices, (d) explain the major elements that constitute a generic SLP methodology, (e) show how the introduction of the SLP methodology in the early stages of new device development can reduce the cost of technology development, and (f) outline the procedure for combining the results of ALT and RTT, establishing degradation mechanisms, using sufficient numbers of samples, and applying the SLP methodology to produce a SLP for existing or new PV technologies.

  16. Using Hierarchical Linear Modeling to Examine How Individual SLPs Differentially Contribute to Children's Language and Literacy Gains in Public Schools.

    Science.gov (United States)

    Farquharson, Kelly; Tambyraja, Sherine R; Logan, Jessica; Justice, Laura M; Schmitt, Mary Beth

    2015-08-01

    The purpose of this study was twofold: (a) to determine the unique contributions in children's language and literacy gains, over 1 academic year, that are attributable to the individual speech-language pathologist (SLP) and (b) to explore possible child- and SLP-level factors that may further explain SLPs' contributions to children's language and literacy gains. Participants were 288 kindergarten and 1st-grade children with language impairment who were currently receiving school-based language intervention from SLPs. Using hierarchical linear modeling, we partitioned the variance in children's gains in language (i.e., grammar, vocabulary) and literacy (i.e., word decoding) that could be attributed to their individual SLP. Results revealed a significant contribution of individual SLPs to children's gains in grammar, vocabulary, and word decoding. Children's fall language scores and grade were significant predictors of SLPs' contributions, although no SLP-level predictors were significant. The present study makes a first step toward incorporating implementation science and suggests that, for children receiving school-based language intervention, variance in child language and literacy gains in an academic year is at least partially attributable to SLPs. Continued work in this area should examine the possible SLP-level characteristics that may further explicate the relative contributions of SLPs.

  17. Changes in Sea-Level Pressure over South Korea Associated with High-Speed Solar Wind Events

    CERN Document Server

    Cho, Il-Hyun; Marubashi, Katsuhide; Kim, Yeon-Han; Park, Young-Deuk; Chang, Heon-Young

    2011-01-01

    We explore a possibility that the daily sea-level pressure (SLP) over South Korea responds to the high-speed solar wind event. This is of interest in two aspects: First, if there is a statistical association this can be another piece of evidence showing that various meteorological observables indeed respond to variations in the interplanetary environment. Second, this can be a very crucial observational constraint since most models proposed so far are expected to preferentially work in higher latitude regions than the low latitude region studied here. We have examined daily solar wind speed ${\\rm V}$, daily SLP difference ${\\rm \\Delta SLP}$, and daily ${\\rm \\log(BV^{2})}$ using the superposed epoch analysis in which the key date is set such that the daily solar wind speed exceeds 800 ${\\rm kms^{-1}}$. We find that the daily ${\\rm \\Delta SLP}$ averaged out of 12 events reaches its peak at day +1 and gradually decreases back to its normal level. The amount of positive deviation of ${\\rm \\Delta SLP}$ is +2.5 hPa...

  18. Hiding the Source Based on Limited Flooding for Sensor Networks

    Directory of Open Access Journals (Sweden)

    Juan Chen

    2015-11-01

    Full Text Available Wireless sensor networks are widely used to monitor valuable objects such as rare animals or armies. Once an object is detected, the source, i.e., the sensor nearest to the object, generates and periodically sends a packet about the object to the base station. Since attackers can capture the object by localizing the source, many protocols have been proposed to protect source location. Instead of transmitting the packet to the base station directly, typical source location protection protocols first transmit packets randomly for a few hops to a phantom location, and then forward the packets to the base station. The problem with these protocols is that the generated phantom locations are usually not only near the true source but also close to each other. As a result, attackers can easily trace a route back to the source from the phantom locations. To address the above problem, we propose a new protocol for source location protection based on limited flooding, named SLP. Compared with existing protocols, SLP can generate phantom locations that are not only far away from the source, but also widely distributed. It improves source location security significantly with low communication cost. We further propose a protocol, namely SLP-E, to protect source location against more powerful attackers with wider fields of vision. The performance of our SLP and SLP-E are validated by both theoretical analysis and simulation results.

  19. Structures, properties, and energy-storage mechanisms of the semi-lunar process cuticles in locusts

    Science.gov (United States)

    Wan, Chao; Hao, Zhixiu; Feng, Xiqiao

    2016-10-01

    Locusts have excellent jumping and kicking abilities to survive in nature, which are achieved through the energy storage and release processes occurring in cuticles, especially in the semi-lunar processes (SLP) at the femorotibial joints. As yet, however, the strain energy-storage mechanisms of the SLP cuticles remain unclear. To decode this mystery, we investigated the microstructure, material composition, and mechanical properties of the SLP cuticle and its remarkable strain energy-storage mechanisms for jumping and kicking. It is found that the SLP cuticle of adult Locusta migratoria manilensis consists of five main parts that exhibit different microstructural features, material compositions, mechanical properties, and biological functions in storing strain energy. The mechanical properties of these five components are all transversely isotropic and strongly depend on their water contents. Finite element simulations indicate that the two parts of the core region of the SLP cuticle likely make significant contributions to its outstanding strain energy-storage ability. This work deepens our understanding of the locomotion behaviors and superior energy-storage mechanisms of insects such as locusts and is helpful for the design and fabrication of strain energy-storage devices.

  20. bessel functions for axisymmetric elasticity problems of the elastic ...

    African Journals Online (AJOL)

    HOD

    ELASTIC HALF SPACE SOIL: A POTENTIAL FUNCTION METHOD. C. C. Ike1 ... OF CIVIL ENGR., ENUGU STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY, ENUGU, ENUGU STATE. ..... Elasticity, Third Edition,McGraw Hill, New York.

  1. Surface wave propagation in a fluid-saturated incompressible porous medium

    Indian Academy of Sciences (India)

    Rajneesh Kumar; B S Hundal

    2007-06-01

    A study of surface wave propagation in a fluid-saturated incompressible porous half-space lying under a uniform layer of liquid is presented. The dispersion relation connecting the phase velocity with wave number is derived. The variation of phase velocity and attenuation coefficients with wave number is presented graphically and discussed. As a particular case, the propagation of Rayleigh type surface waves at the free surface of an incompressible porous half-space is also deduced and discussed.

  2. Compressible Flow Produced by Distributed Sources of Mass: An Exact Solution

    OpenAIRE

    Clarke, J.F.

    1987-01-01

    The paper considers the case of a one-dimensional isentropic unsteady compressible flow that is driven entirely by a distribution of sources in the left-hand half space of an unbounded domain. The right-hand half-space contains no sources, so that source-strength drops discontinuously to zero as one crosses from left to right-hand space. Exact solutions are obtained for those parts of the flow that remain isentropic.

  3. Stationary Light Pulses without Bragg Gratings

    CERN Document Server

    Lin, Yen-Wei; Peters, Thorsten; Liao, Wen-Te; Cho, Hung-Wen; Guan, Pei-Chen; Yu, Ite A

    2008-01-01

    The underlying mechanism of the stationary light pulse (SLP) was identified as a band gap being created by a Bragg grating formed by two counter-propagating coupling fields of similar wavelength. Here we present a more general view of the formation of SLPs, namely several balanced four-wave mixing processes sharing the same ground-state coherence. Utilizing this new concept we report the first experimental observation of a bichromatic SLP at wavelengths for which no Bragg grating can be established. We also demonstrate the production of a SLP directly from a propagating light pulse without prior storage. Being easily controlled externally makes SLPs a very versatile tool for low-light-level nonlinear optics and quantum information manipulation.

  4. Role of S-layer proteins in bacteria.

    Science.gov (United States)

    Gerbino, E; Carasi, P; Mobili, P; Serradell, M A; Gómez-Zavaglia, A

    2015-12-01

    S-layers are paracrystalline bidimensional arrays of proteins or glycoproteins that overlay the cell surface of several genus and species of bacteria and archaea. As the outermost layer of several genus and species of microorganisms, S-layer proteins (SLP) are in direct contact with bacterial environment and thus may be involved in many of their surface properties, including adherence to various substrates, mucins and eukaryotic cells, aggregation and coaggregation with yeasts and other bacteria. In addition, SLP have been reported to be responsible for the bacterial protection against detrimental environmental conditions and to play an important role in surface recognition or as carriers of virulence factors. In this mini-review, we bring together the latest evidences about functional and mechanical properties of bacterial SLP from two different perspectives: (A) their role on bacterial adherence to different substrates and surfaces, and (B) their role as mechanical barriers in bacterial harmful environments.

  5. The role of the speech-language pathologist in the schools for the treatment of voice disorders: working within the framework of the individuals with disabilities education improvement act.

    Science.gov (United States)

    Ruddy, Bari Hoffman; Lewis, Vicki; Sapienza, Christine M

    2013-05-01

    The role of the speech-language pathologist (SLP) has developed considerably over the past 20 years given the medical and technological advances in life-sustaining procedures. Children born with congenital, surgical, or "medically fragile" conditions become mainstreamed into regular school-based settings, thus extending the traditional role of the treating SLP and multidisciplinary team. Understanding the impact of associated voice disorders on educational performance requires dissemination of additional and important information, as eligibility decisions for students in school-based settings must be made within the framework of the federal legislation and regulations governing the provision of services for students with disabilities. This article discusses how to identify children with voice disorders under the Individuals with Disabilities Education Improvement Act (IDEA), the role of the SLP in various triaging scenarios, and how models of voice therapy can be integrated in a school-based setting.

  6. The effect of the magnetic nanoparticle's size dependence of the relaxation time constant on the specific loss power of magnetic nanoparticle hyperthermia

    Science.gov (United States)

    Harabech, Mariem; Leliaert, Jonathan; Coene, Annelies; Crevecoeur, Guillaume; Van Roost, Dirk; Dupré, Luc

    2017-03-01

    Magnetic nanoparticle hyperthermia is a cancer treatment in which magnetic nanoparticles (MNPs) are subjected to an alternating magnetic field to induce heat in the tumor. The generated heat of MNPs is characterized by the specific loss power (SLP) due to relaxation phenomena of the MNP. Up to now, several models have been proposed to predict the SLP, one of which is the Linear Response Theory. One parameter in this model is the relaxation time constant. In this contribution, we employ a macrospin model based on the Landau-Lifshitz-Gilbert equation to investigate the relation between the Gilbert damping parameter and the relaxation time constant. This relaxation time has a pre-factor τ0 which is often taken as a fixed value ranging between 10-8 and 10-12 s. However, in reality it has small size dependence. Here, the influence of this size dependence on the calculation of the SLP is demonstrated, consequently improving the accuracy of this estimate.

  7. A methodology for spatial data selection for statistical downscaling purposes. A case study of precipitation in southwestern Europe

    Energy Technology Data Exchange (ETDEWEB)

    Woth, K. [GKSS-Forschungszentrum Geesthacht GmbH (Germany). Inst. fuer Kuestenforschung

    2001-07-01

    In this study, the sensitivity of the estimation of small-scale climate variables using the technique of statistical downscaling is investigated and one method to select the most suitable input data is presented. For the example of precipitation in southwest Europe, the input data are selected systematically by extracting those stations that show a strong statistical relation in time with North Atlantic sea level pressure (SLP). From these stations the sector of North Atlantic SLP is selected that best explains the dominant spatial pattern of regional precipitation. For comparison, one alternative, slightly different geographical box is used. For both sectors a statistical model for the estimation of future rainfall in the southwest of Europe is constructed. It is shown that the method of statistical downscaling is sensitive to small changes of the input data and that the estimations of future precipitation show remarkable differences for the two different Atlantic SLP sectors considered. Possible reasons are discussed. (orig.)

  8. Pressure Vessel Optimization a Fuzzy Approach

    Directory of Open Access Journals (Sweden)

    Mr. Uday V. Aswalekar

    2015-05-01

    Full Text Available Optimization has become a significant area of development, both in research and for practicing design engineers. In this work here for optimization of air receiver tank, of reciprocating air compressor, the sequential linear programming method is being used. The capacity of tank is considered as optimization constraint. Conventional dimension of the tank are utilized as reference for defining range. Inequality constraints such as different design stresses for different parts of tank are determined and suitable values are selected. Algorithm is prepared and conventional SLP is done in MATLAB Software with C++ interface toget optimized dimension of tank. The conventional SLP is modified by introducing fuzzy heuristics and the relevant algorithm is prepared. Fuzzy based sequential linear programming is prepared and executed in MATLAB Software using fuzzy toolbox and optimization tool box and corresponding dimension are obtained. After comparison FSLP with SLP it is observed that FSLP is easier in execution.

  9. Virus induced gene silencing of three putative prolyl 4-hydroxylases enhances plant growth in tomato (Solanum lycopersicum).

    Science.gov (United States)

    Fragkostefanakis, Sotirios; Sedeek, Khalid E M; Raad, Maya; Zaki, Marwa Samir; Kalaitzis, Panagiotis

    2014-07-01

    Proline hydroxylation is a major posttranslational modification of hydroxyproline-rich glycoproteins (HRGPs) that is catalyzed by prolyl 4-hydroxylases (P4Hs). HRGPs such as arabinogalactan proteins (AGPs) and extensios play significant roles on cell wall structure and function and their implication in cell division and expansion has been reported. We used tobacco rattle virus (TRV)-based virus induced gene silencing to investigate the role of three tomato P4Hs, out of ten present in the tomato genome, in growth and development. Eight-days old tomato seedlings were infected with the appropriate TRV vectors and plants were allowed to grow under standard conditions for 6 weeks. Lower P4H mRNA levels were associated with lower hydroxyproline content in root and shoot tissues indicating successful gene silencing. P4H-silenced plants had longer roots and shoots and larger leaves. The increased leaf area can be attributed to increased cell division as indicated by the higher leaf epidermal cell number in SlP4H1- and SlP4H9-silenced plants. In contrast, SlP4H7-silenced plants had larger leaves due to enhanced cell expansion. Western blot analysis revealed that silencing of SlP4H7 and SlP4H9 was associated with reduced levels of JIM8-bound AGP and JIM11-bound extensin epitopes, while silencing of SlP4H1 reduced only the levels of AGP proteins. Collectively these results show that P4Hs have significant and distinct roles in cell division and expansion of tomato leaves.

  10. Evolution of bacterial-like phosphoprotein phosphatases in photosynthetic eukaryotes features ancestral mitochondrial or archaeal origin and possible lateral gene transfer.

    Science.gov (United States)

    Uhrig, R Glen; Kerk, David; Moorhead, Greg B

    2013-12-01

    Protein phosphorylation is a reversible regulatory process catalyzed by the opposing reactions of protein kinases and phosphatases, which are central to the proper functioning of the cell. Dysfunction of members in either the protein kinase or phosphatase family can have wide-ranging deleterious effects in both metazoans and plants alike. Previously, three bacterial-like phosphoprotein phosphatase classes were uncovered in eukaryotes and named according to the bacterial sequences with which they have the greatest similarity: Shewanella-like (SLP), Rhizobiales-like (RLPH), and ApaH-like (ALPH) phosphatases. Utilizing the wealth of data resulting from recently sequenced complete eukaryotic genomes, we conducted database searching by hidden Markov models, multiple sequence alignment, and phylogenetic tree inference with Bayesian and maximum likelihood methods to elucidate the pattern of evolution of eukaryotic bacterial-like phosphoprotein phosphatase sequences, which are predominantly distributed in photosynthetic eukaryotes. We uncovered a pattern of ancestral mitochondrial (SLP and RLPH) or archaeal (ALPH) gene entry into eukaryotes, supplemented by possible instances of lateral gene transfer between bacteria and eukaryotes. In addition to the previously known green algal and plant SLP1 and SLP2 protein forms, a more ancestral third form (SLP3) was found in green algae. Data from in silico subcellular localization predictions revealed class-specific differences in plants likely to result in distinct functions, and for SLP sequences, distinctive and possibly functionally significant differences between plants and nonphotosynthetic eukaryotes. Conserved carboxyl-terminal sequence motifs with class-specific patterns of residue substitutions, most prominent in photosynthetic organisms, raise the possibility of complex interactions with regulatory proteins.

  11. H2O incorporation in the phosphorene/a-SiO2 interface: a first-principles study

    Science.gov (United States)

    Scopel, Wanderlã L.; Souza, Everson S.; Miwa, R. H.

    2017-02-01

    Based on first-principles calculations, we investigate (i) the energetic stability and electronic properties of single-layer phosphorene (SLP) adsorbed on an amorphous SiO2 surface (SLP/a-SiO2), and (ii) the further incorporation of water molecules at the phosphorene/a-SiO2 interface. In (i), we find that the phosphorene sheet binds to a-SiO2 through van der Waals interactions, even in the presence of oxygen vacancies on the surface. The SLP/a-SiO2 system presents a type-I band alignment, with the valence (conduction) band maximum (minimum) of the phosphorene lying within the energy gap of the a-SiO2 substrate. The structure and the surface-potential corrugations promote the formation of electron-rich and electron-poor regions on the phosphorene sheet and at the SLP/a-SiO2 interface. Such charge density puddles are strengthened by the presence of oxygen vacancies in a-SiO2. In (ii), because of the amorphous structure of the surface, we consider a number of plausible geometries for H2O embedded in the SLP/a-SiO2 interface. There is an energetic preference for the formation of hydroxyl (OH) groups on the a-SiO2 surface. Meanwhile, in the presence of oxygenated water or interstitial oxygen in the phosphorene sheet, we observe the formation of metastable OH bonded to the phosphorene, and the formation of energetically stable P-O-Si chemical bonds at the SLP/a-SiO2 interface. Further x-ray absorption spectra simulations are performed, which aim to provide additional structural/electronic information on the oxygen atoms forming hydroxyl groups or P-O-Si chemical bonds at the interface region.

  12. Assessing Stationarity in Ice Core Record-Sea Level Pressure Relationships for Yukon Territory Ice Core Records

    Science.gov (United States)

    Kelsey, E. P.; Wake, C. P.; Osterberg, E. C.

    2014-12-01

    We assess the stationarity of the relationship between Northern Hemisphere winter (Dec-Feb) sea-level pressure (SLP) and proxy time series (major ions, accumulation, and stable isotopes) from the Eclipse (3017 m asl) and the Mt. Logan Prospector-Russell Col (PRCol; 5340 m asl) ice cores from Yukon, Canada. We develop a novel spatial calibration procedure to identify ranges of ice core values that are associated with consistent winter SLP anomaly patterns. Each ice core variable time series was ranked and divided into groups of 13 years each. We assess stationarity by splitting the 1872-2001 analysis period in half (1872-1936 and 1937-2001) and comparing the locations and magnitudes of SLP anomaly patterns during the two periods for each group of ice core values. Northern Hemisphere monthly mean SLP from the 20th Century Reanalysis dataset are used. The high accumulation rate (1.38 m a-1) at Eclipse allows us to analyze 6-month seasonal mean values (Oct-Mar and Apr-Sep), whereas annual mean values are used from PRCol where the accumulation rate is lower (0.40 m a-1). The Eclipse cold season accumulation and PRCol annual mean sodium concentrations (Na+) exhibit the strongest correlations with winter SLP anomaly patterns. In particular, the lowest and highest 20% annual Na+ values at PRCol and lowest 10% cold season accumulation values at Eclipse exhibit stationarity with consistent SLP anomaly patterns in the North Pacific for all three time periods. A weaker Aleutian Low consistently occurred in the central to eastern North Pacific for the lowest Na+ years at PRCol and lowest accumulation cold seasons at Eclipse, although these groups of years are mostly independent. A stronger Aleutian Low occurs in the North Pacific for the highest Na+ years at PRCol. A stationary SLP anomaly pattern is not observed through all three time periods for high cold season accumulation at Eclipse. Application of this calibration procedure with other traditional calibration and

  13. Stationary Light Pulses in Cold Atomic Media

    CERN Document Server

    Liao, Wen-Te; Peters, Thorsten; Chou, Hung-Chih; Wang, Jian-Siung; Kuan, Pei-Chen; Yu, Ite A

    2008-01-01

    Stationary light pulses (SLPs), i.e., light pulses without motion, are formed via the retrieval of stored probe pulses with two counter-propagating coupling fields. We show that there exist non-negligible hybrid Raman excitations in media of cold atoms that prohibit the SLP formation. We experimentally demonstrate a method to suppress these Raman excitations and realize SLPs in laser-cooled atoms. Our work opens the way to SLP studies in cold as well as in stationary atoms and provides a new avenue to low-light-level nonlinear optics.

  14. Two transgenic mouse models for β-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations

    DEFF Research Database (Denmark)

    Kacso, Gergely; Ravasz, Dora; Doczi, Judit;

    2016-01-01

    -forming activity. Bioenergetic parameters including substrate-level phosphorylation (SLP) were not different between wild-type and Sucla2 heterozygote mice unless a submaximal pharmacological inhibition of SUCL was concomitantly present. mtDNA contents were moderately decreased, but blood carnitine esters were...... expression, yielding double heterozygote mice with no alterations in GTP-forming activity or SLP, but more pronounced changes in mtDNA content and blood carnitine esters, and an increase in succinate dehydrogenase activity. We conclude that a partial reduction in Sucla2 elicits rebound increases in Suclg2...

  15. Physical limits of pure superparamagnetic Fe3O4 nanoparticles for a local hyperthermia agent in nanomedicine

    Science.gov (United States)

    Jeun, Minhong; Lee, Sanghoon; Kyeong Kang, Jae; Tomitaka, Asahi; Wook Kang, Keon; Il Kim, Young; Takemura, Yasushi; Chung, Kyung-Won; Kwak, Jiyeon; Bae, Seongtae

    2012-02-01

    Magnetic and AC magnetically induced heating characteristics of Fe3O4 nanoparticles (IONs) with different mean diameters, d, systematically controlled from 4.2 to 22.5 nm were investigated to explore the physical relationship between magnetic phase and specific loss power (SLP) for hyperthermia agent applications. It was experimentally confirmed that the IONs had three magnetic phases and correspondingly different SLP characteristics depending on the particle sizes. Furthermore, it was demonstrated that pure superparamagnetic phase IONs (d limiting for hyperthermia applications due to smaller AC hysteresis loss power (Néel relaxation loss power) originated from lower out-of-phase magnetic susceptibility.

  16. Tratamiento percutáneo de la enfermedad coronaria en pacientes diabéticos mediante stent liberador de Tacrolimus.

    OpenAIRE

    Ferrer Gracia, Maria Cruz; Sabaté Tena, Manel; Pérez Lorenz, Juan Blas; Macaya Miguel, Carlos

    2009-01-01

    La diabetes (DM) es predictor de reestenosis y eventos clínicos tras la revascularización coronaria percutánea. Los stents liberadores de fármacos (sirolimus [SLS] y paclitaxel [SLP]) resultan más beneficiosos que los convencionales (SC) en este contexto. Estudiamos la efectividad del stent liberador de tacrolimus en estos pacientes frente a SLS, SLP y SC. Se trata de un estudio prospectivo, multicéntrico en el que se incluyeron 80 pacientes de características similares (30% DM insulinodepen...

  17. Two-Dimensional Gel Electrophoresis Analyses of pH-Dependent Protein Expression in Facultatively Alkaliphilic Bacillus pseudofirmus OF4 Lead to Characterization of an S-Layer Protein with a Role in Alkaliphily

    Science.gov (United States)

    Gilmour, Raymond; Messner, Paul; Guffanti, Arthur A.; Kent, Rebecca; Scheberl, Andrea; Kendrick, Nancy; Krulwich, Terry Ann

    2000-01-01

    The large majority of proteins of alkaliphilic Bacillus pseudofirmus OF4 grown at pH 7.5 and 10.5, as studied by two-dimensional gel electrophoresis analyses, did not exhibit significant pH-dependent variation. A new surface layer protein (SlpA) was identified in these studies. Although the prominence of some apparent breakdown products of SlpA in gels from pH 10.5-grown cells led to discovery of the alkaliphile S-layer, the largest and major SlpA forms were present in large amounts in gels from pH 7.5-grown cells as well. slpA RNA abundance was, moreover, unchanged by growth pH. SlpA was similar in size to homologues from nonalkaliphiles but contained fewer Arg and Lys residues. An slpA mutant strain (RG21) lacked an exterior S-layer that was identified in the wild type by electron microscopy. Electrophoretic analysis of whole-cell extracts further indicated the absence of a 90-kDa band in the mutant. This band was prominent in wild-type extracts from both pH 7.5- and 10.5-grown cells. The wild type grew with a shorter lag phase than RG21 at either pH 10.5 or 11 and under either Na+-replete or suboptimal Na+ concentrations. The extent of the adaptation deficit increased with pH elevation and suboptimal Na+. By contrast, the mutant grew with a shorter lag and faster growth rate than the wild type at pH 7.5 under Na+-replete and suboptimal Na+ conditions, respectively. Logarithmically growing cells of the two strains exhibited no significant differences in growth rate, cytoplasmic pH regulation, starch utilization, motility, Na+-dependent transport of α-aminoisobutyric acid, or H+-dependent synthesis of ATP. However, the capacity for Na+-dependent pH homeostasis was diminished in RG21 upon a sudden upward shift of external pH from 8.5 to 10.5. The energy cost of retaining the SlpA layer at near-neutral pH is apparently adverse, but the constitutive presence of SlpA enhances the capacity of the extremophile to adjust to high pH. PMID:11029415

  18. Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions : Lesion Clearance Is Related to the Strength of the T-Cell Response

    OpenAIRE

    van Poelgeest, Mariëtte I E; Welters, Marij J. P.; Vermeij, Renee; Stynenbosch, Linda F M; Loof, Nikki M; Berends-van der Meer, Dorien M A; Löwik, Margriet J G; Hamming, Ineke L E; van Esch, Edith M G; Hellebrekers, Bart W. J.; Beurden, Marc; Schreuder, Henk W; Kagie, Marjolein J; Trimbos, J. Baptist M. Z.; Fathers, Lorraine M.

    2016-01-01

    PURPOSE: Therapeutic vaccination with human papillomavirus type 16 (HPV16) E6 and E7 synthetic long peptides (SLP) is effective against HPV16-induced high-grade vulvar and vaginal intraepithelial neoplasia (VIN/VaIN). However, clinical nonresponders displayed weak CD8(+) T-cell reactivity. Here, we studied if imiquimod applied at the vaccine site could improve CD8(+) T-cell reactivity, clinical efficacy, and safety of HPV16-SLP (ISA101). EXPERIMENTAL DESIGN: A multicenter open-label, randomiz...

  19. Two transgenic mouse models for β-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations

    DEFF Research Database (Denmark)

    Kacso, Gergely; Ravasz, Dora; Doczi, Judit

    2016-01-01

    -forming activity. Bioenergetic parameters including substrate-level phosphorylation (SLP) were not different between wild-type and Sucla2 heterozygote mice unless a submaximal pharmacological inhibition of SUCL was concomitantly present. mtDNA contents were moderately decreased, but blood carnitine esters were...... expression, yielding double heterozygote mice with no alterations in GTP-forming activity or SLP, but more pronounced changes in mtDNA content and blood carnitine esters, and an increase in succinate dehydrogenase activity. We conclude that a partial reduction in Sucla2 elicits rebound increases in Suclg2...

  20. Treatment of chronic anovulation and corpus luteum deficiency with epimestrol.

    Science.gov (United States)

    Cortes-Prieto, J; Martinez, M R; Pesenti, B; Villalobos, A S; Clavijo, M G

    1981-01-01

    Ten patients presenting with anovulatory syndrome (AS, 4 patients), inadequate luteal phase (ILP, 3 patients) and short luteal phase (SLP, 3 patients) were treated with epimestrol for 29 cycles in total. The initial treatment was always 10 mg/day for 10 days followed by a modification of the daily dose and/or length of treatment needed. Ovulation was induced in all 4 AS patients with an adequate luteal phase (ALP) in 3 of them. In all other patients (with ILP and SLP) an ALP was induced; 2 of them became pregnant. No side-effects were reported.

  1. Sawfly larval poisoning in cattle: Report on new outbreaks and brief review of the literature

    Directory of Open Access Journals (Sweden)

    Bianca Tessele

    2012-11-01

    Full Text Available Sawfly larval poisoning (SLP is an acute hepatotoxicosis documented in livestock in Australia, Denmark and in countries of South America. It is caused by the ingestion of the larval stage of insects of the suborder Symphyta, order Hymenoptera, commonly known as "sawfly". Three species of sawfly are reportedly involved in the toxicosis. The insect involved in Australian SLP is Lophyrotoma interrupta (Pergidae, in Denmark the cause of SLP is the ingestion of the larvae Arge pullata (Argidae, and in South American countries documented outbreaks of SLP were caused by the ingestion of yet another sawfly, Perreyia flavipes (Pergidae. In all geographical areas where it occurred, SLP causes important livestock losses. In cattle, as well as in other affected species, the disease has a short clinical course and in many outbreaks affected cattle can be found dead. When observed, clinical signs include apathy, recumbence, tremors, paddling movements and death in 24-48 hours. Neurological signs such aggressiveness attributable to hepatic encephalopathy are also observed. In cases with a more protracted course icterus and photodermatitis may develop. Gross findings included ascites, petechiae and ecchymosis over serosal surfaces of thoracic and abdominal cavities, and an enlarged liver that displays accentuation of the lobular pattern and edema of the gall bladder wall. Sawfly larval body fragments and heads are consistently found in the fore stomachs and occasionally abomasum of affected cattle. Main microscopic lesions are restricted to the liver and consist of centrolobular (periacinar to massive hepatocellular necrosis. In most lobules necrotic areas extended up to the portal triads where only a few viable hepatocytes remain. Mild to moderate lymphocyte necrosis is seen in lymphatic tissues. Cases occur in the winter months when the larval stages of the sawfly are developing. D-amino acid-containing peptides have been found to be the toxic principle in

  2. Evaluation of a Portable DVD Player and System of Least Prompts to Self-Prompt Cooking Task Completion by Young Adults with Moderate Intellectual Disabilities

    Science.gov (United States)

    Mechling, Linda C.; Gast, David L.; Fields, Elizabeth A.

    2008-01-01

    This study evaluated the effectiveness of a portable DVD player plus the system of least prompts (SLP) for DVD player use as a self-prompting device to teach cooking tasks to three young adults with moderate intellectual disabilities. A multiple probe design across three cooking tasks and replicated across three students was used to evaluate the…

  3. Electrochemical techniques for characterization of stem-loop probe and linear probe-based DNA sensors.

    Science.gov (United States)

    Lai, Rebecca Y; Walker, Bryce; Stormberg, Kent; Zaitouna, Anita J; Yang, Weiwei

    2013-12-15

    Here we present a summary of the sensor performance of the stem-loop probe (SLP) and linear probe (LP) electrochemical DNA sensors when interrogated using alternating current voltammetry (ACV), cyclic voltammetry (CV), and differential pulse voltammetry (DPV). Specifically, we identified one critical parameter for each voltammetric technique that can be adjusted for optimal sensor performance. Overall, the SLP sensor displayed good sensor performance (i.e., 60+% signal attenuation in the presence of the target) over a wider range of experimental conditions when compared to the LP sensor. When used with ACV, the optimal frequency range was found to be between 5 and 5000 Hz, larger than the 5-100 Hz range observed with the LP sensor. A similar trend was observed for the two sensors in CV; the LP sensor was operational only at scan rates between 30 and 100 V/s, whereas the SLP sensor performed well at scan rates between 1 and 1000 V/s. Unlike ACV and CV, DPV has demonstrated to be a more versatile sensor interrogation technique for this class of sensors. Despite the minor differences in total signal attenuation upon hybridization to the target DNA, both SLP and LP sensors performed optimally under most pulse widths used in this study. More importantly, when used with longer pulse widths, both sensors showed "signal-on" behavior, which is generally more desirable for sensor applications.

  4. Quantitative single serum-dilution liquid phase competitive blocking ELISA for the assessment of herd immunity and expected protection against foot-and-mouth disease virus in vaccinated cattle.

    Science.gov (United States)

    Robiolo, Blanca; La Torre, José; Duffy, Sergio; Leon, Emilio; Seki, Cristina; Torres, Adriana; Mattion, Nora

    2010-06-01

    A single serum-dilution liquid phase ELISA (slpELISA) was standardized to be used for serological evaluation of herd immunity against foot-and-mouth disease. The absorbance value at a dilution 1:64 of each serum sample was interpolated in a standard curve by plotting the antibody titers of six control sera determined by end point dilution liquid phase ELISA (lpELISA), against the absorbance values for the same control sera at 1:64 dilutions. A straight line was obtained by linear regression analysis (r>0.90) in the titer range of 1.40-2.40. The reliability of the antibody titers was confirmed by the simultaneous titration of 60 cattle sera by slpELISA and lpELISA, which showed an acceptable correlation (R(2)>0.87) for viral strains A24/Cruzeiro, A/Argentina/01, O1/Campos and C3/Indaial. Titers obtained by both methods were not significantly different (p>0.05), thus confirming that slpELISA could be used successfully to replace the conventional serial dilution ELISA for the assessment of protection status of cattle in epidemiological studies. In addition, this quantitative slpELISA provides an adequate method for monitoring the effectiveness of vaccination campaigns and is also suitable for the assessment of seroconversion of naive animals during early stages of infection.

  5. Communication performance of children with Down Syndrome: An ICF-CY based multiple case study

    NARCIS (Netherlands)

    Deckers, S.R.J.M.; Zaalen, Y. van; Stoep, J.M.G.M.; Balkom, L.J.M. van; Verhoeven, L.T.W.

    2016-01-01

    Enhancing communication performance skills may help children with Down Syndrome (DS) to expand their opportunities for participation in daily life. It is a clinical challenge for speech-language pathologists (SLP) to disentangle various mechanisms that contribute to the language and communication

  6. Speech Sound Disorders in a Community Study of Preschool Children

    Science.gov (United States)

    McLeod, Sharynne; Harrison, Linda J.; McAllister, Lindy; McCormack, Jane

    2013-01-01

    Purpose: To undertake a community (nonclinical) study to describe the speech of preschool children who had been identified by parents/teachers as having difficulties "talking and making speech sounds" and compare the speech characteristics of those who had and had not accessed the services of a speech-language pathologist (SLP). Method:…

  7. Photosynthetic efficiency of Chlorella sorokiniana in a turbulently mixed short light-path photobioreactor

    NARCIS (Netherlands)

    Kliphuis, A.M.J.; Winter, de L.; Vejrazka, C.; Martens, D.E.; Janssen, M.G.J.; Wijffels, R.H.

    2010-01-01

    To be able to study the effect of mixing as well as any other parameter on productivity of algal cultures, we designed a lab-scale photobioreactor in which a short light path (SLP) of (12 mm) is combined with controlled mixing and aeration. Mixing is provided by rotating an inner tube in the

  8. Actinomycete integrative and conjugative elements

    NARCIS (Netherlands)

    Poele, Evelien M. te; Bolhuis, Henk; Dijkhuizen, Lubbert

    2008-01-01

    This paper reviews current knowledge on actinomycete integrative and conjugative elements (AICEs). The best characterised AICEs, pSAM2 of Streptomyces ambofaciens (10.9 kb), SLP1 (17.3 kb) of Streptomyces coelicolor and pMEA300 of Amycolatopsis methanolica (13.3 kb), are present as integrative eleme

  9. Repeatability and Reproducibility of Retinal Nerve Fiber Layer Parameters Measured by Scanning Laser Polarimetry with Enhanced Corneal Compensation in Normal and Glaucomatous Eyes

    Directory of Open Access Journals (Sweden)

    Mirian Ara

    2015-01-01

    Full Text Available Objective. To assess the intrasession repeatability and intersession reproducibility of peripapillary retinal nerve fiber layer (RNFL thickness parameters measured by scanning laser polarimetry (SLP with enhanced corneal compensation (ECC in healthy and glaucomatous eyes. Methods. One randomly selected eye of 82 healthy individuals and 60 glaucoma subjects was evaluated. Three scans were acquired during the first visit to evaluate intravisit repeatability. A different operator obtained two additional scans within 2 months after the first session to determine intervisit reproducibility. The intraclass correlation coefficient (ICC, coefficient of variation (COV, and test-retest variability (TRT were calculated for all SLP parameters in both groups. Results. ICCs ranged from 0.920 to 0.982 for intravisit measurements and from 0.910 to 0.978 for intervisit measurements. The temporal-superior-nasal-inferior-temporal (TSNIT average was the highest (0.967 and 0.946 in normal eyes, while nerve fiber indicator (NFI; 0.982 and inferior average (0.978 yielded the best ICC in glaucomatous eyes for intravisit and intervisit measurements, respectively. All COVs were under 10% in both groups, except NFI. TSNIT average had the lowest COV (2.43% in either type of measurement. Intervisit TRT ranged from 6.48 to 12.84. Conclusions. The reproducibility of peripapillary RNFL measurements obtained with SLP-ECC was excellent, indicating that SLP-ECC is sufficiently accurate for monitoring glaucoma progression.

  10. 78 FR 14074 - Foreign-Trade Zone 189-Kent/Ottawa/Muskegon Counties, MI, Notification of Proposed Production...

    Science.gov (United States)

    2013-03-04

    ... Foreign-Trade Zones Board Foreign-Trade Zone 189--Kent/Ottawa/Muskegon Counties, MI, Notification of Proposed Production Activity, Southern Lithoplate, Inc., (Aluminum Printing Plates), Grand Rapids, Michigan... Board (15 CFR 400.22) was received on February 22, 2013. The SLP facility is located within Site 10 of...

  11. Evidence-based practice in speech-language pathology curricula: a scoping study.

    Science.gov (United States)

    Togher, Leanne; Yiannoukas, Corina; Lincoln, Michelle; Power, Emma; Munro, Natalie; Mccabe, Patricia; Ghosh, Pratiti; Worrall, Linda; Ward, Elizabeth; Ferguson, Alison; Harrison, Elisabeth; Douglas, Jacinta

    2011-12-01

    This scoping study investigated how evidence-based practice (EBP) principles are taught in Australian speech-language pathology (SLP) teaching and learning contexts. It explored how Australian SLP university programs: (1) facilitate student learning about the principles of EBP in academic and clinical settings, and (2) self-evaluate their curricula in relation to EBP. The research involved two surveys. Survey 1 respondents were 131 academic staff, program coordinators, and on-campus and off-campus clinical educators. This survey gathered information about EBP teaching and learning in SLP programs as well as future EBP curriculum plans. Survey 2 investigated how clinical educators incorporated EBP into the way they taught clinical decision-making to students. Surveys responses from 85 clinical educators were analysed using descriptive and non-parametric statistics and thematic grouping of open-ended qualitative responses. Both surveys revealed strengths and gaps in integrating EBP into Australian SLP curricula. Perceived strengths were that respondents were positive about EBP, most had EBP training and access to EBP resources. The perceived gaps included the academic staff's perceptions of students' understanding and application of EBP, respondents' understanding of research methodologies, communication and collaboration between academic staff and clinical educators, and a lack of explicit discussion by clinical educators and students of EBP in relation to clients.

  12. Immunoassay of paralytic shellfish toxins by moving magnetic particles in a stationary liquid-phase lab-on-a-chip.

    Science.gov (United States)

    Kim, Myoung-Ho; Choi, Suk-Jung

    2015-04-15

    In this study, we devised a stationary liquid-phase lab-on-a-chip (SLP LOC), which was operated by moving solid-phase magnetic particles in the stationary liquid phase. The SLP LOC consisted of a sample chamber to which a sample and reactants were added, a detection chamber containing enzyme substrate solution, and a narrow channel connecting the two chambers and filled with buffer. As a model system, competitive immunoassays of saxitoxin (STX), a paralytic shellfish toxin, were conducted in the SLP LOC using protein G-coupled magnetic particles (G-MPs) as the solid phase. Anti-STX antibodies, STX-horseradish peroxidase conjugate, G-MPs, and a STX sample were added to the sample chamber and reacted by shaking. While liquids were in the stationary state, G-MPs were transported from the sample chamber to the detection chamber by moving a magnet below the LOC. After incubation to allow the enzymatic reaction to occur, the absorbance of the detection chamber solution was found to be reciprocally related to the STX concentration of the sample. Thus, the SLP LOC may represent a novel, simple format for point-of-care testing applications of enzyme-linked immunosorbent assays by eliminating complicated liquid handling steps.

  13. Identification of a Novel Bcl10 Domain that Contributes to NK-kappaB Activation

    Science.gov (United States)

    2012-08-22

    Phosphorylation of ITAMs induces recruitment of ZAP -70, a kinase that is phosphorylated and activated by Lck. ZAP -70 then phosphorylates additional downstream...clusters in T cells. Nature, 1998. 395(6697): p. 82-6. 12. Bubeck Wardenburg, J., et al., Phosphorylation of SLP-76 by the ZAP -70 protein- tyrosine

  14. Surface (S)-layer proteins of Deinococcus radiodurans and their utility as vehicles for surface localization of functional proteins.

    Science.gov (United States)

    Misra, Chitra Seetharam; Basu, Bhakti; Apte, Shree Kumar

    2015-12-01

    The radiation resistant bacterium, Deinococcus radiodurans contains two major surface (S)-layer proteins, Hpi and SlpA. The Hpi protein was shown to (a) undergo specific in vivo cleavage, and (b) closely associate with the SlpA protein. Using a non-specific acid phosphatase from Salmonella enterica serovar Typhi, PhoN as a reporter, the Surface Layer Homology (SLH) domain of SlpA was shown to bind deinococcal peptidoglycan-containing cell wall sacculi. The association of SlpA with Hpi on one side and peptidoglycan on the other, localizes this protein in the 'interstitial' layer of the deinoccocal cell wall. Gene chimeras of hpi-phoN and slh-phoN were constructed to test efficacy of S-layer proteins, as vehicles for cell surface localization in D. radiodurans. The Hpi-PhoN protein localized exclusively in the membrane fraction, and displayed cell-based phosphatase activity in vivo. The SLH-PhoN, which localized to both cytosolic and membrane fractions, displayed in vitro activity but no cell-based in vivo activity. Hpi, therefore, emerged as an efficient surface localizing protein and can be exploited for suitable applications of this superbug.

  15. Cell surface hydrophobicity is conveyed by S-layer proteins - A study in recombinant lactobacilli

    NARCIS (Netherlands)

    Mei, H.C. van der; Belt-Gritter, B. van de; Pouwels, P.H.; Martinez, B.; Busscher, H.J.

    2003-01-01

    Cell surface hydrophobicity is one of the most important factors controlling adhesion of microorganisms to surfaces. In this paper, cell surface properties of lactobacilli and recombinant lactobacilli with and without a surface layer protein (SLP) associated with cell surface hydrophobicity were det

  16. Characterization of pMC11, a plasmid with dual origins of replication isolated from Lactobacillus casei MCJ and construction of shuttle vectors with each replicon

    DEFF Research Database (Denmark)

    Chen, Zhengjun; Lin, Jinzhong; Ma, Chengjie

    2014-01-01

    %. These vectors were employed to express a green fluorescent protein (GFP) using the promoter of S-layer protein SlpA from Lactobacillus acidophilus. And a growth-phase regulated expression of GFP was observed in different strains. In conclusion, these shuttle vectors provide efficient genetic tools for DNA...

  17. Cell surface hydrophobicity is conveyed by S-layer proteins - A study in recombinant lactobacilli

    NARCIS (Netherlands)

    Mei, H.C. van der; Belt-Gritter, B. van de; Pouwels, P.H.; Martinez, B.; Busscher, H.J.

    2003-01-01

    Cell surface hydrophobicity is one of the most important factors controlling adhesion of microorganisms to surfaces. In this paper, cell surface properties of lactobacilli and recombinant lactobacilli with and without a surface layer protein (SLP) associated with cell surface hydrophobicity were det

  18. The key role of topography in altering North Atlantic atmospheric circulation during the last glacial period

    Directory of Open Access Journals (Sweden)

    F. S. R. Pausata

    2011-10-01

    Full Text Available The Last Glacial Maximum (LGM; 21 000 yr before present was a period of low atmospheric greenhouse gas concentrations, when vast ice sheets covered large parts of North America and Europe. Paleoclimate reconstructions and modeling studies suggest that the atmospheric circulation was substantially altered compared to today, both in terms of its mean state and its variability. Here we present a suite of coupled model simulations designed to investigate both the separate and combined influences of the main LGM boundary condition changes (greenhouse gases, ice sheet topography and ice sheet albedo on the mean state and variability of the atmospheric circulation as represented by sea level pressure (SLP and 200-hPa zonal wind in the North Atlantic sector. We find that ice sheet topography accounts for most of the simulated changes during the LGM. Greenhouse gases and ice sheet albedo affect the SLP gradient in the North Atlantic, but the overall placement of high and low pressure centers is controlled by topography. Additional analysis shows that North Atlantic sea surface temperatures and sea ice edge position do not substantially influence the pattern of the climatological-mean SLP field, SLP variability or the position of the North Atlantic jet in the LGM.

  19. Relationship between Eurasian large-scale patterns and regional climate variability over the Black and Baltic Seas

    Energy Technology Data Exchange (ETDEWEB)

    Stankunavicius, G.; Pupienis, D. [Vilnius Univ. (Lithuania). Dept. of Hydrology and Climatology; Basharin, D. [National Academy of Science of Ukraine, Sevastopol (Ukraine). Sevastopol Marine Hydrophysical Inst.

    2012-11-01

    Using a NCEP/NCAR Reanalysis dataset and the empirical orthogonal function (EOF) analysis approach we studied interannual to decadal variabilities of the sea-level air pressure (SLP) and the surface air temperature (SAT) fields over Eurasia during the 2nd part of the 20th century. Our results agree with those of the previous studies, which conclude that Eurasian trends are the result of storm-path changes driven by the interdecadal behaviour of the NAO-like meridional dipole pattern in the Atlantic. On interannual and decadal time scales, significant synchronous correlations between correspondent modes of SAT and SLP EOF patterns were found. This fact suggests that there is a strong and stable Eurasian interrelationship between SAT and SLP large-scale fields which affects the local climate of two sub-regions: the Black and Baltic Seas. The climate variability in these sub-regions was studied in terms of Eurasian large-scale surface-temperature and air-pressure patterns responses. We concluded that the sub-regional climate variability substantially differs over the Black and Baltic Seas, and depends on different Eurasian large-scale patterns. We showed that the Baltic Sea region is influenced by the patterns arising primary from NAO-like meridional dipole, as well as Scandinavian patterns, while the Black Sea's SAT/SLP variability is influenced mainly by the second mode EOF (eastern Atlantic) and large scale tropospheric wave structures. (orig.)

  20. Effect of a multi-level intervention on nurse—patient communication in the intensive care unit: Results of the SPEACS trial

    Science.gov (United States)

    Happ, Mary Beth; Garrett, Kathryn L.; Tate, Judith A.; DiVirgilio, Dana; Houze, Martin P.; Demirci, Jill R.; George, Elisabeth; Sereika, Susan M.

    2014-01-01

    Objective To test the impact of two levels of intervention on communication frequency, quality, success, and ease between nurses and intubated intensive care unit (ICU) patients. Design Quasi-experimental, 3-phase sequential cohort study: (1) usual care, (2) basic communication skills training (BCST) for nurses, (3) additional training in augmentative and alternative communication devices and speech language pathologist consultation (AAC + SLP). Trained observers rated four 3-min video-recordings for each nurseepatient dyad for communication frequency, quality and success. Patients self-rated communication ease. Setting Two ICUs in a university-affiliated medical center. Participants 89 intubated patients awake, responsive and unable to speak and 30 ICU nurses. Main results Communication frequency (mean number of communication acts within a communication exchange) and positive nurse communication behaviors increased significantly in one ICU only. Percentage of successful communication exchanges about pain were greater for the two intervention groups than the usual care/control group across both ICUs (p = .03) with more successful sessions about pain and other symptoms in the AAC + SLP group (p = .07). Patients in the AAC SLP intervention group used significantly more AAC methods (p = .002) and rated communication at high difficulty less often (p communication skills training, materials and SLP consultation intervention in the ICU. PMID:24495519

  1. Integrating Speech-Language Pathology Services in Palliative End-of-Life Care

    Science.gov (United States)

    Pollens, Robin D.

    2012-01-01

    Clinical speech-language pathologists (SLPs) may receive referrals to consult with teams serving patients who have a severe and/or terminal disease. Palliative care focuses on the prevention or relief of suffering to maximize quality of life for these patients and their families. This article describes how the role of the SLP in palliative care…

  2. Use of the Response to Intervention Model for Remediation of Mild Articulation Errors by Speech-Language Pathologists in Indiana Public Schools

    Science.gov (United States)

    Fritz-Ocock, Amy

    2016-01-01

    The role of the school speech-language pathologist (SLP) has recently evolved to reflect national trends of educational reform. In an era of accountability for all student learning, Response to Intervention (RTI) has become the predominant vehicle for providing preventative, intensified instruction to students at risk. School SLPs in Indiana have…

  3. California's wind energy resource: seasonal, synoptic, and diurnal characteristics, and variability on several time scales

    Science.gov (United States)

    Mansbach, D. K.; Cayan, D. R.

    2009-12-01

    Decades worth of observational data are used to analyze the annual cycle, relevant synoptic climatology, and diurnal patterns of wind in California's major wind generation regions. Wind records near the wind farms at San Gorgonio and Tehachapi passes, Southern California, and Solano County, Northern California near Sacramento are employed. The in situ data are complemented by global reanalysis, 10-km dynamically downscaled regional reanalysis, and other weather station and buoy data. Each site shows preferred wind directions dictated by local orographic forcing as well as different peaks in wind speed and direction distribution in each season, which are explained in terms of climatological circulation patterns. All have greater wind energy in the warmer months, although the northern site peaks later in the summer, more in phase with the temperature cycle but lagging the cycle in zonal SLP gradient that the other sites align with. The dominant patterns associated with high winds, classified with self-organizing maps, feature a North Pacific SLP high and western North American low. The interplay between synoptic forcing and local circulations is also explored. Local circulations are especially important in the warm months when mesoscale SLP gradients are set up by diurnal heating. The northernmost site displays sharp diurnal wind increases as remnants of a sea breeze propagate inland to the site and amplify the wind induced by the cross-valley SLP gradient.

  4. 76 FR 39455 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of...

    Science.gov (United States)

    2011-07-06

    ...) (extending the operation of the New Market Model and the SLP Pilots to November 30, 2009); 61075 (November 30... operation of the New Market Model Pilot to January 31, 2012). 2. Statutory Basis The basis under the... trade, to remove impediments to and perfect the mechanism of a free and open market and a national...

  5. Family Voices at Mealtime: Experiences with Young Children with Visual Impairment

    Science.gov (United States)

    Smyth, Catherine A.; Spicer, Carol L.; Morgese, Zoe L.

    2014-01-01

    Infants with visual impairment often require additional interaction from adults to reinforce behaviors that lead to competency at mealtimes, but parental and professional confidence in teaching these skills is often limited. In the following collective case study, the authors, a speech/language pathologist (S/LP), occupational therapist (OT), and…

  6. A stomatin-domain protein essential for touch sensation in the mouse.

    Science.gov (United States)

    Wetzel, Christiane; Hu, Jing; Riethmacher, Dieter; Benckendorff, Anne; Harder, Lena; Eilers, Andreas; Moshourab, Rabih; Kozlenkov, Alexey; Labuz, Dominika; Caspani, Ombretta; Erdmann, Bettina; Machelska, Halina; Heppenstall, Paul A; Lewin, Gary R

    2007-01-11

    Touch and mechanical pain are first detected at our largest sensory surface, the skin. The cell bodies of sensory neurons that detect such stimuli are located in the dorsal root ganglia, and subtypes of these neurons are specialized to detect specific modalities of mechanical stimuli. Molecules have been identified that are necessary for mechanosensation in invertebrates but so far not in mammals. In Caenorhabditis elegans, mec-2 is one of several genes identified in a screen for touch insensitivity and encodes an integral membrane protein with a stomatin homology domain. Here we show that about 35% of skin mechanoreceptors do not respond to mechanical stimuli in mice with a mutation in stomatin-like protein 3 (SLP3, also called Stoml3), a mammalian mec-2 homologue that is expressed in sensory neurons. In addition, mechanosensitive ion channels found in many sensory neurons do not function without SLP3. Tactile-driven behaviours are also impaired in SLP3 mutant mice, including touch-evoked pain caused by neuropathic injury. SLP3 is therefore indispensable for the function of a subset of cutaneous mechanoreceptors, and our data support the idea that this protein is an essential subunit of a mammalian mechanotransducer.

  7. Problem-based learning (PBL) and speech-language pathology: a tutorial.

    Science.gov (United States)

    Whitehill, Tara L; Bridges, Susan; Chan, Karen

    2014-01-01

    The aim of this tutorial is to provide an introduction to problem-based learning (PBL), particularly as applied to speech-language pathology (SLP) programs. The tutorial is aimed at the reader who is less familiar with this learning approach. Additionally, it serves as a framework for the articles that follow in this special issue on PBL programs in SLP and other clinical education programs. A brief history of PBL is provided and the rationale and context for this approach are identified. PBL is defined and differentiated from related educational approaches. Different models and variations of PBL are outlined. The key components of PBL are further illustrated using the tutorial cycle. Finally, we present one specific case of a PBL-based SLP program in detail. This tutorial will provide a deeper understanding of PBL for many higher educators in SLP. The strengths of this approach are outlined and the challenges are identified, particularly for those contemplating converting an existing "traditional" course or curriculum.

  8. Signals of Antarctic Circum-polar Wave over the Southern Indian Ocean as recorded in an Antarctica ice core

    Institute of Scientific and Technical Information of China (English)

    XIAO Cunde; CHENG Yanjie; REN Jiawen; LU Longhua; LI Zhongqin; QIN Dahe; ZHOU Xiuji

    2005-01-01

    Oxygen stable isotopic and ionic records, covering a period of 1745-1996, are recovered in DT001 ice core drilled in Princess Elizabeth Land, East Antarctica. Using empirical orthogonal function (EOF) analysis of the annually resolved glaciochemical time series, we find the first EOF (EOF1) represents sea-salt aerosols and is the proxy of sea level pressure (SLP) over a quasi-stationary low in the Southern Indian Ocean (SIO).δ18O represents the sea surface temperature (SST) of the same ocean area. In the past two decades, four climatic waves as represented by SLP and SST proxies are found in the DT001 ice core, which in coincident with four Antarctic Circum-polar Waves (ACW) as revealed by NCEP/NCAR reanalysis. The phase difference between SST and SLP in the ice core is also coincident with that in ACW. Both ice-core record and reanalysis suggest that there were no signals of ACW during 1958-1980, none during the overall recording period between 1745-1996, as there is no regular phase difference between SST and SLP. The ACW signal after early 1980s is probably attributable to the climate shift occurring over Antarctic Peninsula-Drake Passage region.

  9. Schoolchildren with Dysphagia Associated with Medically Complex Conditions

    Science.gov (United States)

    Lefton-Greif, Maureen A.; Arvedson, Joan C.

    2008-01-01

    Purpose: This article reviews population trends and general characteristics of children with dysphagia in schools, provides an overview of dysphagia teams and the roles of the speech-language pathologist (SLP) in school and hospital settings, and describes assessment and treatment of swallowing and feeding problems in children with complex medical…

  10. Establishing a Public School Dysphagia Program: A Model for Administration and Service Provision

    Science.gov (United States)

    Homer, Emily M.

    2008-01-01

    Purpose: Many school-based speech-language pathologists (SLPs) are hampered in participating in managing children with dysphagia by their school systems' lack of supportive policies and procedures. A need exists to better define the dysphagia-trained SLP's role and clarify the district's responsibility. The purpose of this article is to address…

  11. Family Voices at Mealtime: Experiences with Young Children with Visual Impairment

    Science.gov (United States)

    Smyth, Catherine A.; Spicer, Carol L.; Morgese, Zoe L.

    2014-01-01

    Infants with visual impairment often require additional interaction from adults to reinforce behaviors that lead to competency at mealtimes, but parental and professional confidence in teaching these skills is often limited. In the following collective case study, the authors, a speech/language pathologist (S/LP), occupational therapist (OT), and…

  12. 77 FR 45390 - Self-Regulatory Organizations; NYSE MKT LLC; Notice of Filing and Immediate Effectiveness of...

    Science.gov (United States)

    2012-07-31

    ... the SLP Pilot to provide incentives for quoting, to enhance competition among the existing group of..., facilitate the trading of larger orders more efficiently and operates to reward aggressive liquidity... liquidity and operates to reward aggressive liquidity providers. Moreover, the instant filing requesting an...

  13. On the Complexity of Numerical Analysis

    DEFF Research Database (Denmark)

    Miltersen, Peter Bro; Kjeldgaard-Pedersen, Johan; Burgisser, Peter;

    2006-01-01

    We study two quite different approaches to understanding the complexity of fundamental problems in numerical analysis. We show that both hinge on the question of understanding the complexity of the following problem, which we call PosSLP: Given a division-free straight-line program producing...... of classical complexity classes) being PSPACE....

  14. Speech and Language Impairments

    Science.gov (United States)

    ... SLP) who can help you identify strategies for teaching and supporting this student, ways to adapt the ... your child’s teachers. Offer support. Demonstrate any assistive technology your child uses and provide any information teachers will need. Find out how you can ...

  15. The Narrow View of Reading Promotes a Broad View of Comprehension

    Science.gov (United States)

    Catts, Hugh W.

    2009-01-01

    Purpose: This article is a response to A. G. Kamhi's proposal of the narrow view of reading. Method: A descriptive approach is used to review research concerning the cognitive basis of reading comprehension. Educational implications for instruction and assessment are considered. The role of the speech-language pathologist (SLP) in intervention…

  16. 75 FR 54671 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of...

    Science.gov (United States)

    2010-09-08

    ... Proposed Rule Change Extending the Operation of Its Supplemental Liquidity Providers Pilot September 1... the operation of its Supplemental Liquidity Providers Pilot (``SLP Pilot'' or ``Pilot'') (See Rule... 1. Purpose The Exchange proposes to extend the operation of its Supplemental Liquidity...

  17. 77 FR 24239 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing of Proposed Rule...

    Science.gov (United States)

    2012-04-23

    ... Change Amending NYSE Rule 107B To Add a Class of Supplemental Liquidity Providers That Are Registered as... proposes to amend NYSE Rule 107B to add a class of Supplemental Liquidity Providers (``SLP'') that are...-Floor market participants referred to as Supplemental Liquidity Providers or ``SLPs.'' \\3\\...

  18. Training Secondary School Teachers in Instructional Language Modification Techniques to Support Adolescents with Language Impairment: A Randomized Controlled Trial

    Science.gov (United States)

    Starling, Julia; Munro, Natalie; Togher, Leanne; Arciuli, Joanne

    2012-01-01

    Purpose: This study evaluated the efficacy of a collaborative intervention where a speech-language pathologist (SLP) trained mainstream secondary school teachers to make modifications to their oral and written instructional language. The trained teachers' uptake of techniques in their whole-class teaching practices and the impact this had on the…

  19. Domain Modeling: NP_001035932.1 [SAHG[Archive

    Lifescience Database Archive (English)

    Full Text Available NP_001035932.1 chr2 Crystal structure of the small GTPase Rab27B complexed with the... Slp homology domain of Slac2-a/melanophilin p2zetd_ chr2/NP_001035932.1/NP_001035932.1_holo_4-144.pdb blast

  20. Therapists Value of Interprofessional Collaboration

    Science.gov (United States)

    De Vries, Dawn R.

    2012-01-01

    The work of occupational (OT), physical (PT), and recreational therapists (RT), as well as speech- language pathologists (SLP), is interrelated and requires effective teamwork and collaboration to optimize patient outcomes and satisfaction. Literature shows that health care professionals are ill prepared to work in an interprofessional manner due…

  1. 75 FR 2573 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Science.gov (United States)

    2010-01-15

    ... matters concerning its previously assigned SLP securities upon termination of this 30-day period. Quoting... halt or trading halt, shall be considered a trading day. (1) The ``Daily NBB Quoting Percentage'' by... at the NBB during each trading day for a calendar month; (2) The ``Daily NBO Quoting Percentage''...

  2. 78 FR 41166 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2013-07-09

    ... Effectiveness of Proposed Rule Change Amending Its Price List To Add Greater Specificity Related to the... quoting requirement in an assigned security pursuant to Rule 107B (quotes of an SLP-Prop and an SLMM of... Non-Displayed Reserve Order that adds liquidity to the Exchange.\\6\\ The Exchange hereby proposes to...

  3. Tumor suppressor function of Bruton tyrosine kinase is independent of its catalytic activity

    NARCIS (Netherlands)

    S. Middendorp; A.J.E. Zijlstra (Esther); R. Kersseboom (Rogier); G.M. Dingjan (Gemma); H. Jumaa; R.W. Hendriks (Rudi)

    2005-01-01

    textabstractDuring B-cell development in the mouse, Bruton tyrosine kinase (Btk) and the adaptor protein SLP-65 (Src homology 2 [SH2] domain-containing leukocyte protein of 65 kDa) limit the expansion and promote the differentiation of pre-B cells. Btk is thought to mainly function

  4. Communication performance of children with Down Syndrome: An ICF-CY based multiple case study

    NARCIS (Netherlands)

    Deckers, S.R.J.M.; Zaalen, Y. van; Stoep, J.M.G.M.; Balkom, L.J.M. van; Verhoeven, L.T.W.

    2016-01-01

    Enhancing communication performance skills may help children with Down Syndrome (DS) to expand their opportunities for participation in daily life. It is a clinical challenge for speech-language pathologists (SLP) to disentangle various mechanisms that contribute to the language and communication pr

  5. An Activity-Based Language Intervention Program for Kindergarten Children: A Retrospective Evaluation

    Science.gov (United States)

    Cohen-Mimran, Ravit; Reznik-Nevet, Liron; Korona-Gaon, Sharon

    2016-01-01

    The purpose of the present study was to examine the effect of a small-group intervention based on the naturalistic approach on 220 children from 3-5 years of age. All kindergarten children received weekly sessions delivered by a SLP in collaboration with the kindergarten teacher. These sessions included various book related activities. Two…

  6. Classification of reflected signals from cavitated tooth surfaces using an artificial intelligence technique incorporating a fiber optic displacement sensor

    Science.gov (United States)

    Rahman, Husna Abdul; Harun, Sulaiman Wadi; Arof, Hamzah; Irawati, Ninik; Musirin, Ismail; Ibrahim, Fatimah; Ahmad, Harith

    2014-05-01

    An enhanced dental cavity diameter measurement mechanism using an intensity-modulated fiber optic displacement sensor (FODS) scanning and imaging system, fuzzy logic as well as a single-layer perceptron (SLP) neural network, is presented. The SLP network was employed for the classification of the reflected signals, which were obtained from the surfaces of teeth samples and captured using FODS. Two features were used for the classification of the reflected signals with one of them being the output of a fuzzy logic. The test results showed that the combined fuzzy logic and SLP network methodology contributed to a 100% classification accuracy of the network. The high-classification accuracy significantly demonstrates the suitability of the proposed features and classification using SLP networks for classifying the reflected signals from teeth surfaces, enabling the sensor to accurately measure small diameters of tooth cavity of up to 0.6 mm. The method remains simple enough to allow its easy integration in existing dental restoration support systems.

  7. Communication performance of children with Down Syndrome: An ICF-CY based multiple case study

    NARCIS (Netherlands)

    Deckers, S.R.J.M.; Zaalen, Y. van; Stoep, J.M.G.M.; Balkom, L.J.M. van; Verhoeven, L.T.W.

    2016-01-01

    Enhancing communication performance skills may help children with Down Syndrome (DS) to expand their opportunities for participation in daily life. It is a clinical challenge for speech-language pathologists (SLP) to disentangle various mechanisms that contribute to the language and communication pr

  8. Induction of p53-Specific Immunity by a p53 Synthetic Long Peptide Vaccine in Patients Treated for Metastatic Colorectal Cancer

    NARCIS (Netherlands)

    Speetjens, Frank M.; Kuppen, PeterJ. K.; Welters, Marij. J. P.; Essahsah, Farah; van den Brink, Anne Marie E. G. Voet; Lantrua, M. Graziella Kallenberg; Valentijn, A. Rob P. M.; Oostendorp, Jaap; Fathers, Lorraine M.; Nijman, Hans W.; Drijfhout, Jan W.; van de Velde, Cornelis J. H.; Melief, Cornelis J. M.; van der Burg, Sjoerd H.

    2009-01-01

    Purpose: The tumor-associated self-antigen p53 is commonly overexpressed in cancer, including colorectal cancer, and can serve as a target for immunotherapy. The safety and immunogenicity of a p53 synthetic long peptide (p53-SLP) vaccine were investigated in patients treated for metastatic colorecta

  9. Effects of penicillin G on morphology and certain physiological parameters of Lactobacillus acidophilus ATCC 4356.

    Science.gov (United States)

    Khaleghi, M; Kasra Kermanshahi, R; Zarkesh-Esfahani, S H

    2011-08-01

    Evidence shows that probiotic bacteria can undergo substantial structural and morphological changes in response to environmental stresses, including antibiotics. Therefore, this study investigated the effects of penicillin G (0.015, 0.03, and 0.06 mg/l) on the morphology and adhesion of Lactobacillus acidophilus ATCC 4356, including the colony morphotype, biofilm production, hydrophobicity, H₂O₂ formation, S-layer structure, and slpA gene expression. Whereas only smooth colonies grew in the presence of penicillin, rough and smooth colony types were observed in the control group. L. acidophilus ATCC 4356 was found to be hydrophobic under normal conditions, yet its hydrophobicity decreased in the presence of the antibiotic. No biofilm was produced by the bacterium, despite testing a variety of different culture conditions; however, treatment with penicillin G (0.015-0.06 mg/l) significantly decreased its production of H₂O₂ formation and altered the S-layer protein structure and slpA gene expression. The S-protein expression decreased with 0.015 mg/l penicillin G, yet increased with 0.03 and 0.06 mg/l penicillin G. In addition, the slpA gene expression decreased in the presence of 0.015 mg/l of the antibiotic. In conclusion, penicillin G was able to alter the S-layer protein production, slpA gene expression, and certain physicochemical properties of Lactobacillus acidophilus ATCC 4356.

  10. Oral Cancer

    Science.gov (United States)

    ... treatment by an SLP are important to restore speech intelligibility and swallowing skills. Treatment often includes helping people ... 8255 Read More Site Help | A–Z Topic Index | Privacy Statement | Terms of Use © 1997-2017 American Speech-Language-Hearing Association

  11. Classification of Intact Stability Standards for Dynamically Supported Craft.

    Science.gov (United States)

    1979-10-01

    under 2OU length arises when the ship reacts to waves with length ar.d velocity the same as that of the slp and with wave crest amidships. He fouLed ...Substantiation",for Boeing Co., March 1977. BOUGUER, P. "Traite du Navire, de la construction et de lea mouvements ", 1746 by P. Bouguer, Paris, 1746. BOVET

  12. Repeatability and Reproducibility of Retinal Nerve Fiber Layer Parameters Measured by Scanning Laser Polarimetry with Enhanced Corneal Compensation in Normal and Glaucomatous Eyes.

    Science.gov (United States)

    Ara, Mirian; Ferreras, Antonio; Pajarin, Ana B; Calvo, Pilar; Figus, Michele; Frezzotti, Paolo

    2015-01-01

    To assess the intrasession repeatability and intersession reproducibility of peripapillary retinal nerve fiber layer (RNFL) thickness parameters measured by scanning laser polarimetry (SLP) with enhanced corneal compensation (ECC) in healthy and glaucomatous eyes. One randomly selected eye of 82 healthy individuals and 60 glaucoma subjects was evaluated. Three scans were acquired during the first visit to evaluate intravisit repeatability. A different operator obtained two additional scans within 2 months after the first session to determine intervisit reproducibility. The intraclass correlation coefficient (ICC), coefficient of variation (COV), and test-retest variability (TRT) were calculated for all SLP parameters in both groups. ICCs ranged from 0.920 to 0.982 for intravisit measurements and from 0.910 to 0.978 for intervisit measurements. The temporal-superior-nasal-inferior-temporal (TSNIT) average was the highest (0.967 and 0.946) in normal eyes, while nerve fiber indicator (NFI; 0.982) and inferior average (0.978) yielded the best ICC in glaucomatous eyes for intravisit and intervisit measurements, respectively. All COVs were under 10% in both groups, except NFI. TSNIT average had the lowest COV (2.43%) in either type of measurement. Intervisit TRT ranged from 6.48 to 12.84. The reproducibility of peripapillary RNFL measurements obtained with SLP-ECC was excellent, indicating that SLP-ECC is sufficiently accurate for monitoring glaucoma progression.

  13. Relationship between Scanning Laser Polarimetry with Enhanced Corneal Compensation and with Variable Corneal Compensation

    Science.gov (United States)

    Kim, Kyung Hoon; Choi, Jaewan; Lee, Chang Hwan; Cho, Beom-Jin; Kook, Michael S.

    2008-01-01

    Purpose To evaluate the structure-function relationships between retinal sensitivity measured by Humphrey visual field analyzer (HVFA) and the retinal nerve fiber layer (RNFL) thickness measured by scanning laser polarimetry (SLP) with variable corneal compensation (VCC) and enhanced corneal compensation (ECC) in glaucomatous and healthy eyes. Methods Fifty-three eyes with an atypical birefringence pattern (ABP) based on SLP-VCC (28 glaucomatous eyes and 25 normal healthy eyes) were enrolled in this cross-sectional study. RNFL thickness was measured by both VCC and ECC techniques, and the visual field was examined by HVFA with 24-2 full-threshold program. The relationships between RNFL measurements in superior and inferior sectors and corresponding retinal mean sensitivity were sought globally and regionally with linear regression analysis in each group. Coefficients of the determination were calculated and compared between VCC and ECC techniques. Results In eyes with ABP, R2 values for the association between SLP parameters and retinal sensitivity were 0.06-0.16 with VCC, whereas they were 0.21-0.48 with ECC. The association of RNFL thickness with retinal sensitivity was significantly better with ECC than with VCC in 5 out of 8 regression models between SLP parameters and HVF parameters (P<0.05). Conclusions The strength of the structure-function association was higher with ECC than with VCC in eyes with ABP, which suggests that the ECC algorithm is a better approach for evaluating the structure-function relationship in eyes with ABP. PMID:18323701

  14. 77 FR 67067 - Medicare Program; Home Health Prospective Payment System Rate Update for Calendar Year 2013...

    Science.gov (United States)

    2012-11-08

    ... Intermediaries RIA Regulatory Impact Analysis SLP Speech Language Pathology Therapy SNF Skilled Nursing Facility... episode rate includes the six HH disciplines (skilled nursing, HH aide, physical therapy, speech-language... facilities, such as skilled nursing facilities, are now being cared for at home. Moreover, the...

  15. Does sea level pressure modulate the dynamic and thermodynamic forcing in the tropical Indian Ocean?

    Digital Repository Service at National Institute of Oceanography (India)

    Nisha, P.G.; Muraleedharan, P.M.; Keerthi, M.G.; Sathe, P.V.; Ravichandran, M.

    place marks the threshold SST which appears to have an inherent relationship with the SLP, especially when the ocean–atmosphere system is coupled. North of 5 degrees S, the LHF peaks at the threshold SST of 27.5 degrees C and decreases gradually...

  16. Accountability for Services for Young Children with Disabilities and the Assessment of Meaningful Outcomes: The Role of the Speech-Language Pathologist

    Science.gov (United States)

    Hebbeler, Kathleen; Rooney, Robin

    2009-01-01

    Purpose: This article describes the federal accountability requirements related to young children with disabilities and the contribution of the speech-language pathologist (SLP) to provide these data through the use of authentic, functional assessments. Method: The article summarizes recent state and federal developments related to assessment for…

  17. 76 FR 68525 - Medicare Program; Home Health Prospective Payment System Rate Update for Calendar Year 2012

    Science.gov (United States)

    2011-11-04

    ... Health Intermediaries RIA Regulatory Impact Analysis SLP Speech Language Pathology Therapy SNF Skilled... nursing, HH aide, physical therapy, speech-language pathology, occupational therapy, and medical social... provision which requires a qualified therapist, instead of a therapy assistant, to perform the...

  18. The influence of drug physical state on the dissolution enhancement of solid dispersions prepared via hot-melt extrusion: a case study using olanzapine.

    Science.gov (United States)

    Pina, Maria Fátima; Zhao, Min; Pinto, João F; Sousa, João J; Craig, Duncan Q M

    2014-04-01

    In this study, we examine the relationship between the physical structure and dissolution behavior of olanzapine (OLZ) prepared via hot-melt extrusion in three polymers [polyvinylpyrrolidone (PVP) K30, polyvinylpyrrolidone-co-vinyl acetate (PVPVA) 6:4, and Soluplus® (SLP)]. In particular, we examine whether full amorphicity is necessary to achieve a favorable dissolution profile. Drug–polymer miscibility was estimated using melting point depression and Hansen solubility parameters. Solid dispersions were characterized using differential scanning calorimetry, X-ray powder diffraction, and scanning electron microscopy. All the polymers were found to be miscible with OLZ in a decreasing order of PVP>PVPVA>SLP. At a lower extrusion temperature (160°C), PVP generated fully amorphous dispersions with OLZ, whereas the formulations with PVPVA and SLP contained 14%-16% crystalline OLZ. Increasing the extrusion temperature to 180°C allowed the preparation of fully amorphous systems with PVPVA and SLP. Despite these differences, the dissolution rates of these preparations were comparable, with PVP showing a lower release rate despite being fully amorphous. These findings suggested that, at least in the particular case of OLZ, the absence of crystalline material may not be critical to the dissolution performance. We suggest alternative key factors determining dissolution, particularly the dissolution behavior of the polymers themselves.

  19. Slope constrained Topology Optimization

    DEFF Research Database (Denmark)

    Petersson, J.; Sigmund, Ole

    1998-01-01

    pointwise bounds on the density slopes. A finite element discretization procedure is described, and a proof of convergence of finite element solutions to exact solutions is given, as well as numerical examples obtained by a continuation/SLP (sequential linear programming) method. The convergence proof...

  20. Proteomic Analysis of ABCA1-Null Macrophages Reveals a Role for Stomatin-Like Protein-2 in Raft Composition and Toll-Like Receptor Signaling.

    Science.gov (United States)

    Chowdhury, Saiful M; Zhu, Xuewei; Aloor, Jim J; Azzam, Kathleen M; Gabor, Kristin A; Ge, William; Addo, Kezia A; Tomer, Kenneth B; Parks, John S; Fessler, Michael B

    2015-07-01

    Lipid raft membrane microdomains organize signaling by many prototypical receptors, including the Toll-like receptors (TLRs) of the innate immune system. Raft-localization of proteins is widely thought to be regulated by raft cholesterol levels, but this is largely on the basis of studies that have manipulated cell cholesterol using crude and poorly specific chemical tools, such as β-cyclodextrins. To date, there has been no proteome-scale investigation of whether endogenous regulators of intracellular cholesterol trafficking, such as the ATP binding cassette (ABC)A1 lipid efflux transporter, regulate targeting of proteins to rafts. Abca1(-/-) macrophages have cholesterol-laden rafts that have been reported to contain increased levels of select proteins, including TLR4, the lipopolysaccharide receptor. Here, using quantitative proteomic profiling, we identified 383 proteins in raft isolates from Abca1(+/+) and Abca1(-/-) macrophages. ABCA1 deletion induced wide-ranging changes to the raft proteome. Remarkably, many of these changes were similar to those seen in Abca1(+/+) macrophages after lipopolysaccharide exposure. Stomatin-like protein (SLP)-2, a member of the stomatin-prohibitin-flotillin-HflK/C family of membrane scaffolding proteins, was robustly and specifically increased in Abca1(-/-) rafts. Pursuing SLP-2 function, we found that rafts of SLP-2-silenced macrophages had markedly abnormal composition. SLP-2 silencing did not compromise ABCA1-dependent cholesterol efflux but reduced macrophage responsiveness to multiple TLR ligands. This was associated with reduced raft levels of the TLR co-receptor, CD14, and defective lipopolysaccharide-induced recruitment of the common TLR adaptor, MyD88, to rafts. Taken together, we show that the lipid transporter ABCA1 regulates the protein repertoire of rafts and identify SLP-2 as an ABCA1-dependent regulator of raft composition and of the innate immune response.

  1. Baseline predictability of daily east Asian summer monsoon circulation indices

    Science.gov (United States)

    Ai, Shucong; Chen, Quanliang; Li, Jianping; Ding, Ruiqiang; Zhong, Quanjia

    2017-05-01

    The nonlinear local Lyapunov exponent (NLLE) method is adopted to quantitatively determine the predictability limit of East Asian summer monsoon (EASM) intensity indices on a synoptic timescale. The predictability limit of EASM indices varies widely according to the definitions of indices. EASM indices defined by zonal shear have a limit of around 7 days, which is higher than the predictability limit of EASM indices defined by sea level pressure (SLP) difference and meridional wind shear (about 5 days). The initial error of EASM indices defined by SLP difference and meridional wind shear shows a faster growth than indices defined by zonal wind shear. Furthermore, the indices defined by zonal wind shear appear to fluctuate at lower frequencies, whereas the indices defined by SLP difference and meridional wind shear generally fluctuate at higher frequencies. This result may explain why the daily variability of the EASM indices defined by zonal wind shear tends be more predictable than those defined by SLP difference and meridional wind shear. Analysis of the temporal correlation coefficient (TCC) skill for EASM indices obtained from observations and from NCEP's Global Ensemble Forecasting System (GEFS) historical weather forecast dataset shows that GEFS has a higher forecast skill for the EASM indices defined by zonal wind shear than for indices defined by SLP difference and meridional wind shear. The predictability limit estimated by the NLLE method is shorter than that in GEFS. In addition, the June-September average TCC skill for different daily EASM indices shows significant interannual variations from 1985 to 2015 in GEFS. However, the TCC for different types of EASM indices does not show coherent interannual fluctuations.

  2. Influence of osmotic stress on the profile and gene expression of surface layer proteins in Lactobacillus acidophilus ATCC 4356.

    Science.gov (United States)

    Palomino, María Mercedes; Waehner, Pablo M; Fina Martin, Joaquina; Ojeda, Paula; Malone, Lucía; Sánchez Rivas, Carmen; Prado Acosta, Mariano; Allievi, Mariana C; Ruzal, Sandra M

    2016-10-01

    In this work, we studied the role of surface layer (S-layer) proteins in the adaptation of Lactobacillus acidophilus ATCC 4356 to the osmotic stress generated by high salt. The amounts of the predominant and the auxiliary S-layer proteins SlpA and SlpX were strongly influenced by the growth phase and high-salt conditions (0.6 M NaCl). Changes in gene expression were also observed as the mRNAs of the slpA and slpX genes increased related to the growth phase and presence of high salt. A growth stage-dependent modification on the S-layer protein profile in response to NaCl was observed: while in control conditions, the auxiliary SlpX protein represented less than 10 % of the total S-layer protein, in high-salt conditions, it increased to almost 40 % in the stationary phase. The increase in S-layer protein synthesis in the stress condition could be a consequence of or a way to counteract the fragility of the cell wall, since a decrease in the cell wall thickness and envelope components (peptidoglycan layer and lipoteichoic acid content) was observed in L. acidophilus when compared to a non-S-layer-producing species such as Lactobacillus casei. Also, the stationary phase and growth in high-salt medium resulted in increased release of S-layer proteins to the supernatant medium. Overall, these findings suggest that pre-growth in high-salt conditions would result in an advantage for the probiotic nature of L. acidophilus ATCC 4356 as the increased amount and release of the S-layer might be appropriate for its antimicrobial capacity.

  3. Genome-Wide Immune Modulation of TLR3-Mediated Inflammation in Intestinal Epithelial Cells Differs between Single and Multi-Strain Probiotic Combination

    Science.gov (United States)

    MacPherson, Chad W.; Shastri, Padmaja; Mathieu, Olivier; Tompkins, Thomas A.; Burguière, Pierre

    2017-01-01

    Genome-wide transcriptional analysis in intestinal epithelial cells (IEC) can aid in elucidating the impact of single versus multi-strain probiotic combinations on immunological and cellular mechanisms of action. In this study we used human expression microarray chips in an in vitro intestinal epithelial cell model to investigate the impact of three probiotic bacteria, Lactobacillus helveticus R0052 (Lh-R0052), Bifidobacterium longum subsp. infantis R0033 (Bl-R0033) and Bifidobacterium bifidum R0071 (Bb-R0071) individually and in combination, and of a surface-layer protein (SLP) purified from Lh-R0052, on HT-29 cells’ transcriptional profile to poly(I:C)-induced inflammation. Hierarchical heat map clustering, Set Distiller and String analyses revealed that the effects of Lh-R0052 and Bb-R0071 diverged from those of Bl-R0033 and Lh-R0052-SLP. It was evident from the global analyses with respect to the immune, cellular and homeostasis related pathways that the co-challenge with probiotic combination (PC) vastly differed in its effect from the single strains and Lh-R0052-SLP treatments. The multi-strain PC resulted in a greater reduction of modulated genes, found through functional connections between immune and cellular pathways. Cytokine and chemokine analyses based on specific outcomes from the TNF-α and NF-κB signaling pathways revealed single, multi-strain and Lh-R0052-SLP specific attenuation of the majority of proteins measured (TNF-α, IL-8, CXCL1, CXCL2 and CXCL10), indicating potentially different mechanisms. These findings indicate a synergistic effect of the bacterial combinations relative to the single strain and Lh-R0052-SLP treatments in resolving toll-like receptor 3 (TLR3)-induced inflammation in IEC and maintaining cellular homeostasis, reinforcing the rationale for using multi-strain formulations as a probiotic. PMID:28099447

  4. A SNARE-Like Protein and Biotin Are Implicated in Soybean Cyst Nematode Virulence.

    Directory of Open Access Journals (Sweden)

    Sadia Bekal

    Full Text Available Phytoparasitic nematodes that are able to infect and reproduce on plants that are considered resistant are referred to as virulent. The mechanism(s that virulent nematodes employ to evade or suppress host plant defenses are not well understood. Here we report the use of a genetic strategy (allelic imbalance analysis to associate single nucleotide polymorphisms (SNPs with nematode virulence genes in Heterodera glycines, the soybean cyst nematode (SCN. To accomplish this analysis, a custom SCN SNP array was developed and used to genotype SCN F3-derived populations grown on resistant and susceptible soybean plants. Three SNPs reproducibly showed allele imbalances between nematodes grown on resistant and susceptible plants. Two candidate SCN virulence genes that were tightly linked to the SNPs were identified. One SCN gene encoded biotin synthase (HgBioB, and the other encoded a bacterial-like protein containing a putative SNARE domain (HgSLP-1. The two genes mapped to two different linkage groups. HgBioB contained sequence polymorphisms between avirulent and virulent nematodes. However, the gene encoding HgSLP-1 had reduced copy number in virulent nematode populations and appears to produce multiple forms of the protein via intron retention and alternative splicing. We show that HgSLP-1 is an esophageal-gland protein that is secreted by the nematode during plant parasitism. Furthermore, in bacterial co-expression experiments, HgSLP-1 co-purified with the SCN resistance protein Rhg1 α-SNAP, suggesting that these two proteins physically interact. Collectively our data suggest that multiple SCN genes are involved in SCN virulence, and that HgSLP-1 may function as an avirulence protein and when absent it helps SCN evade host defenses.

  5. Characterization of adhesive molecule with affinity to Caco-2 cells in Lactobacillus acidophilus by proteome analysis.

    Science.gov (United States)

    Ashida, Nobuhisa; Yanagihara, Sae; Shinoda, Tadashi; Yamamoto, Naoyuki

    2011-10-01

    The adhesive activities of eight Lactobacillus acidophilus strains toward intestinal epithelial Caco-2 cells were studied to understand the probiotic characteristics of the L. acidophilus L-92 strain. Most of the strains, including L-92, showed high adhesive activity; CP23 showed the lowest adhesive activity. CP23 was selected for comparative analysis of cell wall-associated proteins versus the L-92 strain. Cell wall-associated proteins extracted from L-92 and CP23 were subjected to two-dimensional electrophoresis, and major spots observed in the former were compared to the corresponding spots in the latter. To understand the effects of key components of L-92 on its adhesion to Caco-2 cells, 18 spots with stronger signals in L-92 than those in CP23 were identified by a MALDI-TOF/TOF of Ultraflex analysis. Among the identified proteins of L-92, surface-layer protein A (SlpA) was considered strongly involved in adhesion in the eight L. acidophilus strains. To study the importance of SlpA in the adhesion of L. acidophilus, the amounts of SlpA proteins in LiCl extracts of the eight strains were compared by SDSpolyacrylamide gel electrophoresis. As a result, the adhesive abilities of L. acidophilus strains to Caco-2 cells correlated closely to the amount of SlpA in the cells and the productivity of IL-12, an inflammatory cytokine, in all eight strains. These results strongly suggested that SlpA in L. acidophilus might play a key role in its attachment to Caco-2 cells and in the release of IL-12 from dendritic cells.

  6. Scanning laser polarimetry and spectral domain optical coherence tomography for the detection of retinal changes in Parkinson's disease.

    Science.gov (United States)

    Stemplewitz, Birthe; Keserü, Matthias; Bittersohl, Diana; Buhmann, Carsten; Skevas, Christos; Richard, Gisbert; Hassenstein, Andrea

    2015-12-01

    Whether retinal degeneration is part of the degenerative processes in patients with Parkinson's disease (PD) is still unclear. This cross-sectional study was undertaken to compare the retinal morphology of patients with PD and healthy controls using spectral domain optical coherence tomography (SD-OCT) and scanning laser polarimetry (SLP). Both eyes of patients with PD (n = 108) and healthy controls (n = 165) were examined using SD-OCT and SLP on the same day. Data on the thickness of the retinal nerve fibre layer (RNFL) of all quadrants and the macular area were acquired by OCT (Cirrus, Zeiss). The SLP device (Glaucoma diagnostics (GDx), Zeiss) measured the RNFL and calculated the nerve fibre index (NFI). All patients and probands were checked for concomitant ocular disorders by an ophthalmologist. Visual acuity, intraocular pressure (IOP), objective refraction and the anterior and posterior segment were assessed. Patients with PD showed a reduced macular volume and a reduced central subfield thickness in OCT examinations. The RNFL in the different quadrants did not differ significantly from that of controls. SLP data showed a reduced average RNFL thickness, a decreased thickness of the inferior quadrant and an increase of the NFI in patients with PD. PD may be associated with reduced thickness and volume of the macula and a reduced thickness of the RNFL in the inferior quadrant of the retina. Investigations using SD-OCT and SLP revealed distinct but significant differences between patients with PD and healthy controls. © 2015 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

  7. Scanning laser topography and scanning laser polarimetry: comparing both imaging methods at same distances from the optic nerve head.

    Science.gov (United States)

    Kremmer, Stephan; Keienburg, Marcus; Anastassiou, Gerasimos; Schallenberg, Maurice; Steuhl, Klaus-Peter; Selbach, J Michael

    2012-01-01

    To compare the performance of scanning laser topography (SLT) and scanning laser polarimetry (SLP) on the rim of the optic nerve head and its surrounding area and thereby to evaluate whether these imaging technologies are influenced by other factors beyond the thickness of the retinal nerve fiber layer (RNFL). A total of 154 eyes from 5 different groups were examined: young healthy subjects (YNorm), old healthy subjects (ONorm), patients with normal tension glaucoma (NTG), patients with open-angle glaucoma and early glaucomatous damage (OAGE) and patients with open-angle glaucoma and advanced glaucomatous damage (OAGA). SLT and SLP measurements were taken. Four concentric circles were superimposed on each of the images: the first one measuring at the rim of the optic nerve head (1.0 ONHD), the next measuring at 1.25 optic nerve head diameters (ONHD), at 1.5 ONHD and at 1.75 ONHD. The aligned images were analyzed using GDx/NFA software. Both methods showed peaks of RNFL thickness in the superior and inferior segments of the ONH. The maximum thickness, registered by the SLT device was at the ONH rim where the SLP device tended to measure the lowest values. SLT measurements at the ONH were influenced by other tissues besides the RNFL like blood vessels and glial tissues. SLT and SLP were most strongly correlated at distances of 1.25 and 1.5 ONHD. While both imaging technologies are valuable tools in detecting glaucoma, measurements at the ONH rim should be interpreted critically since both methods might provide misleading results. For the assessment of the retinal nerve fiber layer we would like to recommend for both imaging technologies, SLT and SLP, measurements in 1.25 and 1.5 ONHD distance of the rim of the optic nerve head.

  8. Atypical birefringence pattern and the diagnostic ability of scanning laser polarimetry with enhanced corneal compensation in glaucoma.

    Science.gov (United States)

    Rao, Harsha L; Yadav, Ravi K; Begum, Viquar U; Addepalli, Uday K; Senthil, Sirisha; Choudhari, Nikhil S; Garudadri, Chandra S

    2015-03-01

    To evaluate the effect of typical scan score (TSS), when within the acceptable limits, on the diagnostic performance of retinal nerve fibre layer (RNFL) parameters with the enhanced corneal compensation (ECC) protocol of scanning laser polarimetry (SLP) in glaucoma. In a cross-sectional study, 203 eyes of 160 glaucoma patients and 140 eyes of 104 control subjects underwent RNFL imaging with the ECC protocol of SLP. TSS was used to quantify atypical birefringence pattern (ABP) images. Influence of TSS on the diagnostic ability of SLP parameters was evaluated by receiver operating characteristic (ROC) regression models after adjusting for the effect of disease severity [based on mean deviation (MD)] on standard automated perimetry). Diagnostic abilities of all RNFL parameters of SLP increased when the TSS values were higher. This effect was statistically significant for TSNIT (coefficient: 0.08, p<0.001) and inferior average parameters (coefficient: 0.06, p=0.002) but not for nerve fibre indicator (NFI, coefficient: 0.03, p=0.21). In early glaucoma (MD of -5 dB), predicted area under ROC curve (AUC) for TSNIT average parameter improved from 0.642 at a TSS of 90 to 0.845 at a TSS of 100. In advanced glaucoma (MD of -15 dB), AUC for TSNIT average improved from 0.832 at a TSS of 90 to 0.947 at 100. Diagnostic performances of TSNIT and inferior average RNFL parameters with ECC protocol of SLP were significantly influenced by TSS even when the TSS values were within the acceptable limits. Diagnostic ability of NFI was unaffected by TSS values. © 2014 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

  9. 长春市商业用地基准地价演变过程及驱动因子分析%The Evolution Process and Driving Factors of Standard Land Price of Commercial Land in Changchun City,China

    Institute of Scientific and Technical Information of China (English)

    张石磊; 毕忠德; 杨志毅; 王士君

    2011-01-01

    基准地价作为中国城市地价体系的重要组成部分,是政府法定的公示地价之一,也是目前中国地价评估的基础。城市基准地价的动态变化过程中,基准地价价格水平的提升和基准地价空间格局的变化是城市经济发展、城市规划建设共同作用的综合结果。论文以长春市商业用地基准地价为例,探索城市基准地价演变的规律。首先计算长春市1995年至2010年商业用地不同级别的地价环比结构的特征值,分析长春市商业用地基准地价的价格动态变化特征;然后利用ESDA分析工具,通过2006年和2010年长春市商业区段路线价的空间格局变化分析来概括讨论长春%As a momentous part of the urban land price system of China,standard land price(SLP) is one of the statutory public land price of the Chinese government,and it is also the foundation of land price evaluation in China.SLP is the instructive price for the urban land market.On the one hand,SLP reflects the premium level objectively,on the other hand,it is a basic way to government administration and control urban land market,and it is the basis of the appearance of land assets price and calculation of land assets income.In a process of dynamic change of urban SLP,the rise and spatial change of SLP result from comprehensive effects of economic development and city planning construction.Through calculations,the paper takes the SLP of Changchun City as an example to interpret the rule of evolution process.The thesis has first analyzed the dynamic change feature of commercial standard land price by calculation Chain index' eigenvalue in each price level of commercial SLP in Changchun City in 1994-2010.Using exploratory spatial data analysis(ESDA),the paper analyses the street price of commercial land in Changchun City in 2006 and 2010.After the analysis of the basic database structure and trend,the author chooses Kriging method to make interpolating and SLP

  10. Corpus Christi EFH Trawling Effects 2001-2002

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — We compared sediments and benthos of two adjacent zones of the middle Texas coast, one of which was closed to shrimp trawling for 7 months. Findings indicated that...

  11. Aviation Flight Support Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This facility consists of a 75' x 200' hanger with two adjacent helicopter pads located at Felker Army Airfield on Fort Eustis. A staff of Government and contractor...

  12. Diastereodivergent Access to Syn and Anti 3,4-Substituted β-Fluoropyrrolidines: Enhancing or Reversing Substrate Preference

    DEFF Research Database (Denmark)

    Fjelbye, Kasper; Marigo, Mauro; Clausen, Rasmus Prætorius

    2016-01-01

    A practical diastereodivergent access to β-fluoropyrrolidines with two adjacent stereocenters has been demonstrated, by either enhancing or completely reversing the substrate control, in the diastereoselective fluorination of a series of diverse pyrrolidinyl carbaldehydes using organocatalysis...

  13. Calling Anuran Surveys in the West Mountain Wildlife Management Area and the Nulhegan Basin Division of the Silvio O. Conte National Fish and Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — In 1999, the U.S. Fish and Wildlife Service and the Vermont Agency of Natural Resources acquired two adjacent properties encompassing 48,000 acres of former...

  14. Double eruption cyst in a newborn boy. Case report and review of the literature

    National Research Council Canada - National Science Library

    Marissa ZARAKAS, Kyriaki TSINIDOU, Corina TRIANTAFYLLOU, Eleftheria MEGALOGIANNI, Konstantinos I. TOSIOS

    2012-01-01

    ... are uncommon.The case of a 2 month old Caucasian boy with two adjacent eruption cysts, manifesting as a congenital bilobular tumor of smooth surface and blue color, on the mandibular central incisors area is presented...

  15. Degenerate-parabolic partial differential equations with unbounded coefficients, martingale problems, and a mimicking theorem for Ito processes

    CERN Document Server

    Feehan, Paul M N

    2011-01-01

    We solve four intertwined problems, motivated by mathematical finance, concerning degenerate-parabolic partial differential operators and degenerate diffusion processes. First, we consider a parabolic partial differential equation on a half-space whose coefficients are suitably Holder continuous and allowed to grow linearly in the spatial variable and which becomes degenerate along the boundary of the half-space. We establish existence and uniqueness of solutions in weighted Holder spaces which incorporate both the degeneracy at the boundary and the unboundedness of the coefficients. Second, we show that the martingale problem associated with a degenerate elliptic differential operator with unbounded, locally Holder continuous coefficients on a half-space is well-posed in the sense of Stroock and Varadhan. Third, we prove existence, uniqueness, and the strong Markov property for weak solutions to a stochastic differential equation with degenerate diffusion and unbounded coefficients with suitable H\\"older con...

  16. Analytical solution of second Stokes problem of behaviour of rarefied gas with Cercignani boundary accomodation conditions

    CERN Document Server

    Latyshev, A V

    2012-01-01

    Analytical solution of second Stokes problem of behaviour of rarefied gas with Cercignani boundary accomodation conditions The second Stokes problem about behaviour of rarefied gas filling half-space is analytically solved. A plane, limiting half-space, makes harmonious fluctuations in the plane. The kinetic BGK-equation (Bhatnagar, Gross, Krook) is used. The boundary accomodation conditions of Cercignani of reflexion gaseous molecules from a wall are considered. Distribution function of the gaseous molecules is constructed. The velocity of gas in half-space is found, also its value direct at a wall is found. The force resistance operating from gas on border is found. Besides, the capacity of dissipation of the energy falling to unit of area of the fluctuating plate limiting gas is obtained.

  17. Electromagnetic field in matter. Surface enhanced Raman scattering

    Directory of Open Access Journals (Sweden)

    Marian Apostol

    2013-07-01

    Full Text Available The polarization and magnetization degrees of freedom are included in the general treatment of the electromagnetic field in matter, and their governing equations are given. Particular cases of solutions are discussed for polarizable, non-magnetic matter, including quasi-static fields, surface plasmons, propagation, zero-point fluctuations of the eigenmodes, especially for a semi-infinite homogeneous body (half-space. The van der Waals London-Casimir force acting between a neutral nano-particle and a half-space is computed and the response of this electromagnetically coupled system to an external field is given, with relevance for the surface enhanced Raman scattering.

  18. Wave propagation in liquid-saturated porous solid with micropolar elastic skelton at boundary surface

    Institute of Scientific and Technical Information of China (English)

    Rajneesh Kumar; Mahabir Barak

    2007-01-01

    The present study is concerned with the reflection and transmission of plane waves at an interface between homogenous invisicid liquid half space and a micropolar liquid-saturated porous solid half space. The reflection and transmission coefficients of various reflected and transmitted waves with the angle of incident have been obtained.Numerical calculation has been performed for amplitude ratios of various reflected and transmitted waves. Micropolarity and porosity effects on the reflection and transmission coefficients have been depicted graphically. Some particular cases have been deduced from the present formulation.

  19. Reflection of plane micropolar viscoelastic waves at a loosely bonded solid-solid interface

    Indian Academy of Sciences (India)

    Baljeet Singh

    2002-10-01

    A solution of the field equations governing small motions of a micropolar viscoelastic solid half-space is employed to study the reflection and transmission of plane waves at a loosely bonded interface between two dissimilar micropolar viscoelastic solid half-spaces. The amplitude ratios for various reflected and refracted waves are computed for a particular model for different values of bonding parameter. The variations of these amplitude ratios with the angle of incidence are shown graphically. Effects of bonding parameter and viscosity on the amplitude ratios are shown.

  20. Asymptotically Matched Layer (AML) for transient wave propagation in a moving frame of reference

    DEFF Research Database (Denmark)

    Madsen, Stine Skov; Krenk, Steen

    2017-01-01

    The paper presents an Asymptotically Matched Layer (AML) formulation in a moving frame of reference for transient dynamic response of a multi-layer 2D half-space. A displacement based finite element formulation of the convected domain problem is presented together with the AML formulation in which...... the original convolution integrals are represented via two auxiliary displacement-like state-space variables. A parametric study of the AML parameters is conducted for optimizing the absorbing properties. The performance is demonstrated on a single- and a two-layered half-space for various velocities...

  1. Programs EMCUPL and SCHCOPL: computation of electromagnetic coupling on a layered halfspace with complex conductivities

    Science.gov (United States)

    Kauahikaua, James P.; Anderson, Walter L.

    1979-01-01

    A number of efficient numerical computer algorithms are incorporated into a general program called EMCUPL, which calculates the electromagnetic (EM) coupling between two straight wires on the surface of a multilayered half space. Each layer has an isotropic conductivity which may be either real or complex. A second computer program, called SCHCOPL, is described which calculates the coupling for the special case of a Schlumberger or Wenner array also on a multilayered half space. Comparison with other programs shows that EMCUPL is at least as accurate, more generally applicable, and computationally more efficient FORTRAN listings of all subprograms and example calculations are given in the Appendix.

  2. Lactobacillus buchneri S-layer as carrier for an Ara h 2-derived peptide for peanut allergen-specific immunotherapy.

    Science.gov (United States)

    Anzengruber, Julia; Bublin, Merima; Bönisch, Eva; Janesch, Bettina; Tscheppe, Angelika; Braun, Matthias L; Varga, Eva-Maria; Hafner, Christine; Breiteneder, Heimo; Schäffer, Christina

    2017-05-01

    Peanut allergy is an IgE-mediated severe hypersensitivity disorder. The lack of a treatment of this potentially fatal allergy has led to intensive research on vaccine development. Here, we describe the design and initial characterization of a carrier-bound peptide derived from the most potent peanut allergen, Ara h 2, as a candidate vaccine. Based on the adjuvant capability of bacterial surface (S-) layers, a fusion protein of the S-layer protein SlpB from Lactobacillus buchneri CD034 and the Ara h 2-derived peptide AH3a42 was produced. This peptide comprised immunodominant B-cell epitopes as well as one T cell epitope. The fusion protein SlpB-AH3a42 was expressed in E. coli, purified, and tested for its IgE binding capacity as well as for its ability to activate sensitized rat basophil leukemia (RBL) cells. The capacity of Ara h 2-specific IgG rabbit-antibodies raised against SlpB-AH3a42 or Ara h 2 to inhibit IgE-binding was determined by ELISA inhibition assays using sera of peanut allergic patients sensitized to Ara h 2. IgE specific to the SlpB-AH3a42 fusion protein was detected in 69% (25 of 36) of the sera. Despite the recognition by IgE, the SlpB-AH3a42 fusion protein was unable to induce β-hexosaminidase release from sensitized RBL cells at concentrations up to 100ng per ml. The inhibition of IgE-binding to the natural allergen observed after pre-incubation of the 20 sera with rabbit anti-SlpB-AH3a42 IgG was more than 30% for four sera, more than 20% for eight sera, and below 10% for eight sera. In comparison, anti-Ara h 2 rabbit IgG antibodies inhibited binding to Ara h 2 by 48% ±13.5%. Our data provide evidence for the feasibility of this novel approach towards the development of a peanut allergen peptide-based carrier-bound vaccine. Our experiments further indicate that more than one allergen-peptide will be needed to induce a broader protection of patients allergic to Ara h 2.

  3. Bacterial surface layer proteins as a novel capillary coating material for capillary electrophoretic separations

    Energy Technology Data Exchange (ETDEWEB)

    Moreno-Gordaliza, Estefanía, E-mail: emorenog@ucm.es [Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Universiteit Leiden, Einsteinweg 55, 2300, RA, Leiden (Netherlands); Department of Analytical Chemistry, Faculty of Chemistry, Universidad Complutense de Madrid, Avda. Complutense s/n, 28040, Madrid (Spain); Stigter, Edwin C.A. [Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Universiteit Leiden, Einsteinweg 55, 2300, RA, Leiden (Netherlands); Department of Molecular Cancer Research, Universitair Medisch Centrum Utrecht, Wilhelmina Kinder Ziekenhuis, Lundlaan 6, 3584, EA Utrecht (Netherlands); Lindenburg, Petrus W.; Hankemeier, Thomas [Division of Analytical Biosciences, Leiden Academic Centre for Drug Research, Universiteit Leiden, Einsteinweg 55, 2300, RA, Leiden (Netherlands)

    2016-06-07

    A novel concept for stable coating in capillary electrophoresis, based on recrystallization of surface layer proteins on hydrophobized fused silica capillaries, was demonstrated. Surface layer protein A (SlpA) from Lactobacillus acidophilus bacteria was extracted, purified and used for coating pre-silanized glass substrates presenting different surface wettabilities (either hydrophobic or hydrophilic). Contact angle determination on SlpA-coated hydrophobic silica slides showed that the surfaces turned to hydrophilic after coating (53 ± 5°), due to a protein monolayer formation by protein-surface hydrophobic interactions. Visualization by atomic force microscopy demonstrated the presence of a SlpA layer on methylated silica slides displaying a surface roughness of 0.44 ± 0.02 nm. Additionally, a protein layer was visualized by fluorescence microscopy in methylated silica capillaries coated with SlpA and fluorescein isothiocyanate-labeled. The SlpA-coating showed an outstanding stability, even after treatment with 20 mM NaOH (pH 12.3). The electroosmotic flow in coated capillaries showed a partial suppression at pH 7.50 (3.8 ± 0.5 10{sup −9} m{sup 2} V{sup −1} s{sup −1}) when compared with unmodified fused silica (5.9 ± 0.1 10{sup −8} m{sup 2} V{sup −1} s{sup −1}). To demonstrate the potential of this novel coating, the SlpA-coated capillaries were applied for the first time for electrophoretic separation, and proved to be very suitable for the isotachophoretic separation of lipoproteins in human serum. The separations showed a high degree of repeatability (absolute migration times with 1.1–1.8% coefficient-of-variation (CV) within a day) and 2–3% CV inter-capillary reproducibility. The capillaries were stable for more than 100 runs at pH 9.40, and showed to be an exceptional alternative for challenging electrophoretic separations at long-term use. - Highlights: • New coating using recrystallized surface-layer proteins on

  4. Tidal breathing patterns derived from structured light plethysmography in COPD patients compared with healthy subjects

    Directory of Open Access Journals (Sweden)

    Motamedi-Fakhr S

    2016-12-01

    Full Text Available Shayan Motamedi-Fakhr,1 Rachel C Wilson,1 Richard Iles2 1PneumaCare Ltd, Ely, UK; 2Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK Purpose: Differences in tidal breathing patterns have been reported between patients with chronic obstructive pulmonary disease (COPD and healthy individuals using traditional measurement techniques. This feasibility study examined whether structured light plethysmography (SLP – a noncontact, light-based technique – could also detect differences in tidal breathing patterns between patients with COPD and healthy subjects. Patients and methods: A 5 min period of tidal (quiet breathing was recorded in each patient with COPD (n=31 and each healthy subject (n=31, matched for age, body mass index, and sex. For every participant, the median and interquartile range (IQR; denoting within-subject variability of 12 tidal breathing parameters were calculated. Individual data were then combined by cohort and summarized by its median and IQR. Results: After correction for multiple comparisons, inspiratory time (median tI and its variability (IQR of tI were lower in patients with COPD (p<0.001 and p<0.01, respectively as were ratios derived from tI (tI/tE and tI/tTot, both p<0.01 and their variability (p<0.01 and p<0.05, respectively. IE50SLP (the ratio of inspiratory to expiratory flow at 50% tidal volume calculated from the SLP signal was higher (p<0.001 in COPD while SLP-derived time to reach peak tidal expiratory flow over expiratory time (median tPTEFSLP/tE was shorter (p<0.01 and considerably less variable (p<0.001. Thoraco–abdominal asynchrony was increased (p<0.05 in COPD. Conclusion: These early observations suggest that, like traditional techniques, SLP is able to detect different breathing patterns in COPD patients compared with subjects with no respiratory disease. This provides support for further investigation into the potential uses of SLP in assessing clinical conditions and interventions

  5. Relevance Vector Machine and Support Vector Machine Classifier Analysis of Scanning Laser Polarimetry Retinal Nerve Fiber Layer Measurements

    Science.gov (United States)

    Bowd, Christopher; Medeiros, Felipe A.; Zhang, Zuohua; Zangwill, Linda M.; Hao, Jiucang; Lee, Te-Won; Sejnowski, Terrence J.; Weinreb, Robert N.; Goldbaum, Michael H.

    2010-01-01

    Purpose To classify healthy and glaucomatous eyes using relevance vector machine (RVM) and support vector machine (SVM) learning classifiers trained on retinal nerve fiber layer (RNFL) thickness measurements obtained by scanning laser polarimetry (SLP). Methods Seventy-two eyes of 72 healthy control subjects (average age = 64.3 ± 8.8 years, visual field mean deviation =−0.71 ± 1.2 dB) and 92 eyes of 92 patients with glaucoma (average age = 66.9 ± 8.9 years, visual field mean deviation =−5.32 ± 4.0 dB) were imaged with SLP with variable corneal compensation (GDx VCC; Laser Diagnostic Technologies, San Diego, CA). RVM and SVM learning classifiers were trained and tested on SLP-determined RNFL thickness measurements from 14 standard parameters and 64 sectors (approximately 5.6° each) obtained in the circumpapillary area under the instrument-defined measurement ellipse (total 78 parameters). Tenfold cross-validation was used to train and test RVM and SVM classifiers on unique subsets of the full 164-eye data set and areas under the receiver operating characteristic (AUROC) curve for the classification of eyes in the test set were generated. AUROC curve results from RVM and SVM were compared to those for 14 SLP software-generated global and regional RNFL thickness parameters. Also reported was the AUROC curve for the GDx VCC software-generated nerve fiber indicator (NFI). Results The AUROC curves for RVM and SVM were 0.90 and 0.91, respectively, and increased to 0.93 and 0.94 when the training sets were optimized with sequential forward and backward selection (resulting in reduced dimensional data sets). AUROC curves for optimized RVM and SVM were significantly larger than those for all individual SLP parameters. The AUROC curve for the NFI was 0.87. Conclusions Results from RVM and SVM trained on SLP RNFL thickness measurements are similar and provide accurate classification of glaucomatous and healthy eyes. RVM may be preferable to SVM, because it provides a

  6. AcEST: BP914699 [AcEST

    Lifescience Database Archive (English)

    Full Text Available _TULBA Chitinase 1 OS=Tulipa bakeri Align length 42 Score (bit) 64.3 E-value 2.0e.........done Score E Sequences producing significant alignments: (bits) Value sp|Q9SLP4|CHIT1_TULBA Chitinase 1 OS=Tulipa baker...i PE=1 SV=1 64 2e-10 sp|Q7M443|CHIT2_TULBA Chitinase 2 OS=Tulipa baker...SLP4|CHIT1_TULBA Chitinase 1 OS=Tulipa bakeri PE=1 SV=1 Length = 314 Score = 64.3 bits (155), Expect = 2e-10...INPDVDFHFILAFAIDYTSGSSPT 70 >sp|Q7M443|CHIT2_TULBA Chitinase 2 OS=Tulipa bakeri PE=1 SV=1 Length = 275 Score

  7. A combined stochastic programming and optimal control approach to personal finance and pensions

    DEFF Research Database (Denmark)

    Konicz, Agnieszka Karolina; Pisinger, David; Rasmussen, Kourosh Marjani

    2015-01-01

    The paper presents a model that combines a dynamic programming (stochastic optimal control) approach and a multi-stage stochastic linear programming approach (SLP), integrated into one SLP formulation. Stochastic optimal control produces an optimal policy that is easy to understand and implement....... However, explicit solution may not exist, especially when we want to deal with constraints, such as the limits on the portfolio composition, the limits on the insured sum, an inclusion of transaction costs or taxes on capital gains, which are important issues regularly mentioned in the scientic literature....... Two applications are considered: (A) optimal investment, consumption and insured sum for an individual maximizing the expected utility of consumption and bequest, and (B) optimal investment for a pension saver who wishes to maximize the expected utility of retirement benets. Numerical results show...

  8. Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse.

    Science.gov (United States)

    Soares, Helena; Henriques, Ricardo; Sachse, Martin; Ventimiglia, Leandro; Alonso, Miguel A; Zimmer, Christophe; Thoulouze, Maria-Isabel; Alcover, Andrés

    2013-10-21

    How the vesicular traffic of signaling molecules contributes to T cell receptor (TCR) signal transduction at the immunological synapse remains poorly understood. In this study, we show that the protein tyrosine kinase Lck, the TCRζ subunit, and the adapter LAT traffic through distinct exocytic compartments, which are released at the immunological synapse in a differentially regulated manner. Lck vesicular release depends on MAL protein. Synaptic Lck, in turn, conditions the calcium- and synaptotagmin-7-dependent fusion of LAT and TCRζ containing vesicles. Fusion of vesicles containing TCRζ and LAT at the synaptic membrane determines not only the nanoscale organization of phosphorylated TCRζ, ZAP70, LAT, and SLP76 clusters but also the presence of phosphorylated LAT and SLP76 in interacting signaling nanoterritories. This mechanism is required for priming IL-2 and IFN-γ production and may contribute to fine-tuning T cell activation breadth in response to different stimulatory conditions.

  9. Sea level variability at Adriatic coast and its relationship to atmospheric forcing

    Directory of Open Access Journals (Sweden)

    K. Bergant

    2005-09-01

    Full Text Available Sea level (SLH variability at the Adriatic coast was investigated for the period 1872–2001 using monthly average values of observations at 13 tide gauge stations. Linear trends and seasonal cycles were investigated first and removed afterwards from the data. Empirical Orthogonal Functions (EOF analysis was used further on remaining anomalies (SLA to extract the regional intermonthly variability of SLH. It was found that the leading EOF and its principal component (PC explain a major part of SLA variability (92%. The correlation between the reconstructed SLA, based on leading EOF and its PC, and overlapping observed SLA values for selected tide gauge stations is between 0.93 and 0.99. Actual SLH values at tide gauge stations can be reconstructed and some gaps in the data can be filled in on the basis of estimated SLA values if reasonable estimates of long-term trends and seasonal cycles are also available. A strong, seasonally dependent relationship between SLA at the Adriatic coast and atmospheric forcing, represented by sea level pressure (SLP fields, was also found. Comparing the time series of leading PC and gridded SLP data for the period 1948–2001, the highest correlation coefficients (r of –0.92 in winter, –0.84 in spring, –0.66 in summer, and –0.91 in autumn were estimated for a SLP grid point located in northern Italy. The SLP variability on this grid point contains information about the isostatic response of the sea level at the Adriatic coast, but can also be treated as a sort of teleconnection index representing the large-scale SLP variability across central and southern Europe. To some extent the large-scale SLP variability that affects the SLA at the Adriatic coast can be related to the North Atlantic Oscillation (NAO, because significant correlations were found between the NAO index and the first PC of SLA (rwinter=–0.56, rspring=–0.45, rsummer=–0

  10. Fluorescence Spectroscopic Studies on Ovis Lactoperoxidase

    Directory of Open Access Journals (Sweden)

    P. V. Joseph

    2004-01-01

    Full Text Available Ovis lactoperoxidase (sLP, on excitation at 280 nm shows fluorescence emission of a single broad maximum at 332 nm. The conformational stability was measured by unfolding studies in urea and guanidine hydrochloride. The fluorescence intensity gradually decreased with increase in urea concentrations. The decline might have been caused by partial unfolding, affecting some of the tryptophan residues. In 5 M GuHCl concentrations, a red shift in emission maximum to 356 nm was observed. It indicates that tryptophan is buried in the interior of the hydrophobic environment in native folded state and inaccessible to solvent water but on unfolding all get exposed to aqueous environment. Acrylamide is an efficient quencher and the quenching process is essentially homogenous with all tryptophan being accessible. A little quenching is observed for KI is interpreted as sLP has tryptophan residues that are buried inside the core of the protein.

  11. A REDESIGN LAYOUT TO INCREASE PRODUCTIVITY OF A COMPANY

    Directory of Open Access Journals (Sweden)

    Vincentia Kitriastika

    2013-06-01

    Full Text Available This project is conducted in Company X, a passenger cars wheel producing company located in Sunter, North Jakarta. With a view of increasing the productivity of the company, the focus of this project will be redesigned the layout of the factory. The main problem encountered is that the goods are not produced in single location, causing a considerable hindrance in terms of time and distance, and hence efficiency. The redesigning layout process will use SLP method and flow analysis while supported by analysis of assembly line balancing to optimize the layout. Regarding the evaluation process, ARENA software will be used to simulate and identify the bottleneck in the production process, and comparing the layout alternatives to decide the best layout. The best chosen layout according to the simulation and SLP method that supported with flow analysis and assembly line balancing will be used as the master draft layout that will be proposed to Company X.

  12. Review: Sophorolipids A Promising Biosurfactant and it’s Applications

    Directory of Open Access Journals (Sweden)

    Marcos Roberto de Oliveira

    2015-04-01

    Full Text Available Sophorolipids (SLPs are the most promising glycolipid biosurfactants produced in large quantity by several nonpathogenic yeast species, among these Candida bombicola ATCC 22214 is the most studied SLP producing yeast. SLPs composed by the disaccharide sophorose (2’-O-β-D-glucopyranosyl-β-D-glycopyranose linked (β – glycosidically to a long fatty acid chain with generally 16 to 18 atoms of carbon with one or more unsaturation. These compounds have characteristics, which are similar or even superior to the other biosurfactants and surfactants. Some of these advantages are environmental compatibility, high biodegradability, low toxicity, high selectivity and specific activity in a broad range of temperature, pH and salinity conditions. They fulfill the eco-friendly criteria combine Green chemistry and a lower carbon footprint. SLP possess a great potential for application in areas such as: Agriculture, Food, Biomedicine, Bioremediation, Cosmetics and Enhanced Oil Recovery.

  13. On reconciling ground-based with spaceborne normalized radar cross section measurements

    DEFF Research Database (Denmark)

    Baumgartner, Francois; Munk, Jens; Jezek, K C

    2002-01-01

    This study examines differences in the normalized radar cross section, derived from ground-based versus spaceborne radar data. A simple homogeneous half-space model, indicates that agreement between the two improves as 1) the distance from the scatterer is increased; and/or 2) the extinction...

  14. Time domain analysis of thin-wire antennas over lossy ground using the reflection-coefficient approximation

    NARCIS (Netherlands)

    Fernández Pantoja, M.; Yarovoy, A.G.; Rubio Bretones, A.; González García, S.

    2009-01-01

    This paper presents a procedure to extend the methods of moments in time domain for the transient analysis of thin-wire antennas to include those cases where the antennas are located over a lossy half-space. This extended technique is based on the reflection coefficient (RC) approach, which approxim

  15. A Boundary Harnack Principle for Infinity-Laplacian and Some Related Results

    Directory of Open Access Journals (Sweden)

    Bhattacharya Tilak

    2007-01-01

    Full Text Available We prove a boundary comparison principle for positive infinity-harmonic functions for smooth boundaries. As consequences, we obtain (a a doubling property for certain positive infinity-harmonic functions in smooth bounded domains and the half-space, and (b the optimality of blowup rates of Aronsson's examples of singular solutions in cones.

  16. Harmonic measures of the half-plane and balls for the hyperbolic Brownian motion and Ornstein-Uhlenbeck diffusions

    CERN Document Server

    Byczkowski, Tomasz; Graczyk, Piotr; Malecki, Jacek

    2011-01-01

    The purpose of the paper is to provide integral representations of the Poisson kernel for a half-space and balls for hyperbolic Brownian motion and for the classical Ornstein-Uhlenbeck process. The method of proof is based on Girsanov's theorem and yields more complete results as those based on Feynmann-Kac technique.

  17. Assessment of dynamic substructuring of a wind turbine foundation applicable for aeroelastic simulations

    DEFF Research Database (Denmark)

    Damgaard, Mads; Andersen, Lars Vabbersgaard; Ibsen, Lars Bo

    2015-01-01

    -parameter model fitted to the frequency response of the ground, a surface foundation is implemented into the aeroelastic code FLEX5. In case of a horizontal stratum overlaying a homogeneous half-space and within the low frequency range, analyses show that a standard lumped-parametermodel provides an accurate...

  18. Numerical inversion of the Laplace transform in some problems of granular media dynamics

    Science.gov (United States)

    Yavich, Nikolay B.

    2004-04-01

    Approximated value for the vertical displacement of a surface bounding a half space and a layer laying on rigid foundation filled with granular medium caused by a vertical symmetric load is received here. The results obtained for Kandaurov standard linear medium model are used. This model takes in account an internal friction. The Papoulis method of numerical inversion of the Laplace transform is applied.

  19. Normal Stresses in a Granular Material Under Falling Weight Deflectometer loading

    DEFF Research Database (Denmark)

    Ullidtz, Per; Askegaar, Vagn; Sjølin, Finn Ole

    1996-01-01

    to the actual force. When the measured stress is compared to the the stress predicted using Boussinesq's equation for an elastic half-space, a very large difference is observed. At the centerline of the load, the measured stress is about twice the theoretical value. This difference cannot be explained...

  20. Exterior 3D lamb problem: Harmonic load distributed over a surface

    Science.gov (United States)

    Il'yasov, Kh. Kh.; Kravtsov, A. V.; Kuznetsov, S. V.; Sekerzh-Zen'kovich, S. Ya.

    2016-06-01

    The solutions of the exterior Lamb problem with a distributed harmonic surface load acting on the boundary of an elastic half-space are studied. A load normal to the surface and distributed over the surface as the Poisson kernel is considered. The solution is constructed with the use of integral transforms and the finite-element method.

  1. Applying local Green’s functions to study the influence of the crustalstructure on hydrological loading displacements

    NARCIS (Netherlands)

    Dill, Robert; Klemann, Volker; Martinec, Zdeněk; Tesauro, M.

    2015-01-01

    The influence of the elastic Earth properties on seasonal or shorter periodic surface deformations due to atmospheric surface pressure and terrestrial water storage variations is usually modeled by applying a local half-space model or an one dimensional spherical Earth model like PREM from which a u

  2. Effect of boundaries on the dynamic interaction of a liquid-filled porous layer and a supporting continuum

    Indian Academy of Sciences (India)

    M Tajuddin; G Narayan Reddy

    2005-08-01

    A transcendental equation is derived relating wave number and phase velocity of propagation of waves in a partially saturated layered half-space under plane strain conditions. The period equation is derived and discussed for two types of boundaries, permeable and impermeable. In the limiting cases, the problem reduces to more simplified forms as discussed by earlier researchers.

  3. Evaluation of the discrete complex-image method for a NEC-like moment-method solution

    Energy Technology Data Exchange (ETDEWEB)

    Burke, G.J.

    1996-01-05

    The discrete image approximation for the field of a half-space is tested in the NEC antenna modeling program as an alternative to the interpolation method presently used. The accuracy and speed of the discrete image approximation are examined for varying number of images and approximation contour, and the solution for current is obtained on a horizontal wire approaching the interface.

  4. Viscoelastic Pavement Modeling with a Spreadsheet

    DEFF Research Database (Denmark)

    Levenberg, Eyal

    2016-01-01

    The aim herein was to equip civil engineers and students with an advanced pavement modeling tool that is both easy to use and highly adaptive. To achieve this, a mathematical solution for a layered viscoelastic half-space subjected to a moving load was developed and subsequently implemented...

  5. Geometric Hardy inequalities for the sub-elliptic Laplacian on convex domains in the Heisenberg group

    Directory of Open Access Journals (Sweden)

    Simon Larson

    2016-04-01

    Full Text Available Abstract We prove geometric $$L^p$$ L p versions of Hardy’s inequality for the sub-elliptic Laplacian on convex domains $$\\Omega $$ Ω in the Heisenberg group $$\\mathbb {H}^n$$ H n , where convex is meant in the Euclidean sense. When $$p=2$$ p = 2 and $$\\Omega $$ Ω is the half-space given by $$\\langle \\xi , \

  6. Analysis of the dynamic response of layered, elastic media by means of the Fast Fourier Transform

    NARCIS (Netherlands)

    Abdelkarim, A.M.A.M.; Vrouwenvelder, A.C.W.M.

    1999-01-01

    A straightforward method is presented to calculate the three-dimensional response of layered, elastic half-spaces to a dynamic surface loading. The derivation of the method is performed in the wavenumber-frequency domain. Space-frequency domain results are subsequently obtained through the applicati

  7. Comment on "The velocity field due to an oscillating plate in an Oldroyd-B fluid" by C.C. Hopkins and J.R. de Bruyn [Can. J. Phys. 92, 533 (2014)

    CERN Document Server

    Christov, Ivan C

    2015-01-01

    We correct certain errors and ambiguities in the recent pedagogical article by Hopkins and de Bruyn. The early-time asymptotics of the solution to the transient version of Stokes' second problem for an Oldroyd-B fluid in a half-space is presented, as an Appendix, to complement the late-time asymptotics given by Hopkins and de Bruyn.

  8. A unified viscous-spring artificial boundary for 3-D static and dynamic applications

    Institute of Scientific and Technical Information of China (English)

    LIU Jingbo; LI Bin

    2005-01-01

    A method to develop unified artificial boundaries for problems coupling static effect and dynamic effect is proposed. Based on the dynamic viscous-spring artificial boundary and the fundamental solution of static problems in elastic half space, a unified viscous-spring artificial boundary for 3-D static and dynamic applications is established.

  9. A Waveguide Transverse Broad Wall Slot Radiating Between Baffles

    DEFF Research Database (Denmark)

    Dich, Mikael; Rengarajan, S.R.

    1997-01-01

    An analysis of the self impedance of waveguide-fed transverse slots radiating between baffles is presented. The region exterior to the slot is treated as a parallel plate (PP) waveguide which radiates into half space through an aperture in an infinite ground plane. The slot problem is analyzed...

  10. Interaction of a moving charged particle with a spatially dispersive medium. II. Čerenkov and transition radiation

    NARCIS (Netherlands)

    Hoenders, B.J.; Pattanayak, D.N.

    1976-01-01

    In the preceding paper, we obtained expressions for the electromagnetic field generated by the interaction of a uniformly moving electron with a spatially dispersive half-space. One part of the field was identified with Čerenkov radiation and the other part with transition radiation. In this paper i

  11. Atomic decay near a quantized medium of absorbing scatterers

    NARCIS (Netherlands)

    Suttorp, L.G.; van Wonderen, A.J.

    2010-01-01

    The decay of an excited atom in the presence of a medium that both scatters and absorbs radiation is studied with the help of a quantum-electrodynamical model. The medium is represented by a half-space filled with a randomly distributed set of non-overlapping spheres, which consist of a linear absor

  12. 3D time-domain airborne EM modeling for an arbitrarily anisotropic earth

    Science.gov (United States)

    Yin, Changchun; Qi, Yanfu; Liu, Yunhe

    2016-08-01

    Time-domain airborne EM data is currently interpreted based on an isotropic model. Sometimes, it can be problematic when working in the region with distinct dipping stratifications. In this paper, we simulate the 3D time-domain airborne EM responses over an arbitrarily anisotropic earth with topography by edge-based finite-element method. Tetrahedral meshes are used to describe the abnormal bodies with complicated shapes. We further adopt the Backward Euler scheme to discretize the time-domain diffusion equation for electric field, obtaining an unconditionally stable linear equations system. We verify the accuracy of our 3D algorithm by comparing with 1D solutions for an anisotropic half-space. Then, we switch attentions to effects of anisotropic media on the strengths and the diffusion patterns of time-domain airborne EM responses. For numerical experiments, we adopt three typical anisotropic models: 1) an anisotropic anomalous body embedded in an isotropic half-space; 2) an isotropic anomalous body embedded in an anisotropic half-space; 3) an anisotropic half-space with topography. The modeling results show that the electric anisotropy of the subsurface media has big effects on both the strengths and the distribution patterns of time-domain airborne EM responses; this effect needs to be taken into account when interpreting ATEM data in areas with distinct anisotropy.

  13. Negative refraction and positive refraction are not Lorentz covariant

    Energy Technology Data Exchange (ETDEWEB)

    Mackay, Tom G., E-mail: T.Mackay@ed.ac.u [School of Mathematics and Maxwell Institute for Mathematical Sciences, University of Edinburgh, Edinburgh EH9 3JZ (United Kingdom)] [NanoMM - Nanoengineered Metamaterials Group, Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, PA 16802-6812 (United States); Lakhtakia, Akhlesh, E-mail: akhlesh@psu.ed [NanoMM - Nanoengineered Metamaterials Group, Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, PA 16802-6812 (United States)

    2009-12-28

    Refraction into a half-space occupied by a pseudochiral omega material moving at constant velocity was studied by directly implementing the Lorentz transformations of electric and magnetic fields. Numerical studies revealed that negative refraction, negative phase velocity and counterposition are not Lorentz-covariant phenomenons in general.

  14. Quadric solids and computational geometry

    Energy Technology Data Exchange (ETDEWEB)

    Emery, J.D.

    1980-07-25

    As part of the CAD-CAM development project, this report discusses the mathematics underlying the program QUADRIC, which does computations on objects modeled as Boolean combinations of quadric half-spaces. Topics considered include projective space, quadric surfaces, polars, affine transformations, the construction of solids, shaded image, the inertia tensor, moments, volume, surface integrals, Monte Carlo integration, and stratified sampling. 1 figure.

  15. Nonlinear response of superconductors to alternating fields and currents

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, Jason [Iowa State Univ., Ames, IA (United States)

    1997-10-08

    This report discusses the following topics on superconductivity: nonlinearities in hard superconductors such as surface impedance of a type II superconductimg half space and harmonic generation and intermodulation due to alternating transport currents; and nonlinearities in superconducting weak links such as harmonic generation by a long Josephson Junction in a superconducting slab.

  16. Nonlocal thin films in calculations of the Casimir force

    NARCIS (Netherlands)

    Esquivel-Sirvent, R.; Svetovoy, V.B.

    2005-01-01

    The Casimir force is calculated between plates with thin metallic coating. Thin films are described with spatially dispersive (nonlocal) dielectric functions. For thin films the nonlocal effects are more relevant than for half-spaces. However, it is shown that even for film thickness smaller than th

  17. Spatial dispersion in Casimir forces: a brief review

    NARCIS (Netherlands)

    Esquivel-Sirvent, R.; Villarreal, C.; Mochan, W.L.; Contreras-Reyes, A.M.; Svetovoy, V.B.

    2006-01-01

    We present the basic principles of non-local optics in connection with the calculation of the Casimir force between half-spaces and thin films. At currently accessible distances L, non-local corrections amount to about half a per cent, but they increase roughly as 1/L at smaller separations. Self-co

  18. SCATTERING OF SH-WAVES BY AN INTERACTING INTERFACE LINEAR CRACK AND A CIRCULAR CAVITY NEAR BIMATERIAL INTERFACE

    Institute of Scientific and Technical Information of China (English)

    LIU Diankui; LIN Hong

    2004-01-01

    An analytical method is developed for scattering of SH-waves and dynamic stress concentration by an interacting interface crack and a circular cavity near bimaterial interface. A suitable Green's function is contructed, which is the fundamental solution of the displacement field for an elastic half space with a circular cavity impacted by an out-plane harmonic line source loading at the horizontal surface. First, the bimaterial media is divided into two parts along the horizontal interface, one is an elastic half space with a circular cavity and the other is a complete half space.Then the problem is solved according to the procedure of combination and by the Green's function method. The horizontal surfaces of the two half spaces are loaded with undetermined anti-plane forces in order to satisfy continuity conditions at the linking section, or with some forces to recover cracks by means of crack-division technique. A series of Fredholm integral equations of first kind for determining the unknown forces can be set up through continuity conditions as expressed in terms of the Green's function. Moreover, some expressions are given in this paper, such as dynamic stress intensity factor (DSIF) at the tip of the interface crack and dynamic stress concentration factor (DSCF) around the circular cavity edge. Numerical examples are provided to show the influences of the wave numbers,the geometrical location of the interface crack and the circular cavity, and parameter combinations of different media upon DSIF and DSCF.

  19. Exact solution to surface displacement associated with sources ...

    African Journals Online (AJOL)

    user

    International Journal of Engineering, Science and Technology ... Usually an exact solution to the surface displacement in an elastic half space is available for ..... to (ζ1 , ζ 2 ,ζ3 ) by means of the transformation (2.1), i.e, the station (x, y,-h) on.

  20. STRESS CONCENTRATION DUE TO A SPHERICAL VOID UNDER HERTZIAN CONTACT

    Directory of Open Access Journals (Sweden)

    Stelian ALACI,

    2010-06-01

    Full Text Available The present paper presents the method of estimating the stress concentrator effect of a spherical void from an elastic half-space. An essential part consists in estimation of FEM error by finding the contact pressure from half-plane using an analytical method. Next, the stress concentrator effect of the same void, except for placed into elastic space, is found.